FedInvent™ Patent Applications
Application Details for Thursday, June 23, 2022
This page was updated on Sunday, June 26, 2022 at 03:46 PM GMT
Department of Health and Human Services (HHS)
| US 20220192177 | Grant et al. |
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| FUNDED BY |
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| APPLICANT(S) | Children's Medical Center Corporation (Boston, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | Children's Medical Center Corporation (Boston, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Patricia Ellen Grant (Newton, Massachusetts); Drucilla Roberts (Millis, Massachusetts); Esra Abaci Turk (Boston, Massachusetts); Jeffrey N. Stout (Jamaica Plain, Massachusetts); Lawrence L. Wald (Cambridge, Massachusetts); Elfar Adalsteinsson (Belmont, Massachusetts); William Barth (Boston, Massachusetts) |
| ABSTRACT | Provided herein are systems and methods for development and use of a perfusion apparatus comprising a biological phantom created from an ex vivo placenta. In some embodiments, a system is provided for perfusing an ex vivo placenta to be imaged using a magnetic resonance imaging (MRI) device, the system comprising a chamber configured to house the ex vivo placenta therein, the chamber including a first partition separating the chamber into a first portion and a second portion, wherein the ex vivo placenta is housed at least partially in the first portion, and at least one first inlet disposed in the second portion for receiving at least one first tube, the at least one first tube being configured to couple at least one first pump to a fetal compartment of the ex vivo placenta when present in the chamber. |
| FILED | Friday, December 17, 2021 |
| APPL NO | 17/553999 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/021 (20130101) Original (OR) Class Diagnosis; Surgery; Identification A61B 5/055 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/30 (20130101) G01R 33/58 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220192589 | BUTTERWORTH |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Ian BUTTERWORTH (Somerville, Massachusetts) |
| ABSTRACT | A finger insert for use with a nailfold imaging device includes a housing to receive the user's finger and an immersion substance (e.g., immersion oil), and a deformable pad that holds the user's finger in place during imaging, as well as prevent bubble formation in the substance. The housing includes a transparent wall to facilitate imaging of the finger. The transparent wall includes multiple angled portions that prevent or reduce contact between the nailfold and the wall, to ensure sufficient blood flow through the nailfold region for imaging. |
| FILED | Monday, November 01, 2021 |
| APPL NO | 17/516109 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0077 (20130101) A61B 5/0082 (20130101) A61B 5/0261 (20130101) A61B 5/449 (20130101) Original (OR) Class A61B 5/702 (20130101) A61B 5/02241 (20130101) A61B 5/6826 (20130101) A61B 2562/16 (20130101) A61B 2562/146 (20130101) A61B 2562/164 (20130101) A61B 2562/168 (20130101) Image or Video Recognition or Understanding G06V 40/1341 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220192743 | Rollins et al. |
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| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew M. Rollins (Cleveland, Ohio); Xiaowei Zhao (Cleveland, Ohio); Reza Mohammadpour (Cleveland, Ohio) |
| ABSTRACT | A described example provides an ablation catheter including an elongate tubular body having spaced apart proximal and distal ends and a lumen extending through the elongate tubular body. An ablation electrode extends from the distal end of the elongate tubular body to terminate in a distal end thereof. An elongate optical imaging probe extends through the lumen of the elongate tubular body and terminates in a distal end that is spaced a distance from the distal end of the ablation electrode. A flexible tubing extends over a length of the probe and configured to permit at least rotational movement of the probe within the flexible tubing. A distal end portion of the flexible tubing can be held at an axial position relative to the elongate tubular body to fix the distance between the distal end of the probe and the distal end of the ablation electrode. |
| FILED | Thursday, December 16, 2021 |
| APPL NO | 17/552448 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 18/1492 (20130101) Original (OR) Class A61B 2018/00577 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220192919 | Wilson et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert H. Wilson (Irvine, California); Christian Crouzet (Irvine, California); Yama Akbari (Irvine, California); Bernard Choi (Irvine, California); Bruce J. Tromberg (Irvine, California) |
| ABSTRACT | A multimodal optical imaging platform is used to obtain cerebral perfusion-metabolism mismatch metrics for rapid assessment of acute brain injury, ongoing (real-time) feedback to optimize cardiopulmonary resuscitation to improve neurological outcome, and rapid prognosis of recovery. Light of several wavelengths and types is delivered to the tissue, which is then absorbed and scattered by tissue components such as blood and cellular components. Some of this light scatters back to the surface, where it is captured by a detector. The resulting data are processed to obtain blood flow and oxygenation parameters, as well as tissue scattering. These parameters are then combined to calculate metabolism and flow-metabolism coupling/decoupling metrics, which are used to determine ischemic damage, ongoing need for optimal blood flow and oxygenation, and to predict cerebral recovery in patients with acute brain injury during and immediately after cardiac arrest, stroke, traumatic brain injury, etc. |
| FILED | Wednesday, March 09, 2022 |
| APPL NO | 17/690866 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0205 (20130101) A61B 5/0261 (20130101) A61B 5/14552 (20130101) A61B 5/14553 (20130101) Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 31/005 (20130101) Original (OR) Class A61H 2230/207 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/39044 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220192986 | Huebsch et al. |
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| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Nathaniel D. Huebsch (Colma, California); Christopher M. Madl (Vestal, New York); Kangwon Lee (Lexington, Massachusetts); Maria M. Xu (Morgantown, West Virginia); David J. Mooney (Sudbury, Massachusetts) |
| ABSTRACT | The invention provides compositions and methods to form pores in situ within hydrogels following hydrogel injection. Pores formed in situ via degradation of sacrificial porogens within the surrounding hydrogel facilitate recruitment or release of cells. Disclosed herein is a material that is not initially porous, but which becomes macroporous over time. |
| FILED | Tuesday, November 09, 2021 |
| APPL NO | 17/522297 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1652 (20130101) Original (OR) Class Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/20 (20130101) A61L 27/26 (20130101) A61L 27/38 (20130101) A61L 27/48 (20130101) A61L 27/52 (20130101) A61L 27/54 (20130101) A61L 27/56 (20130101) A61L 27/58 (20130101) A61L 2300/414 (20130101) A61L 2400/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193021 | Si et al. |
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| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Longlong Si (Cambridge, Massachusetts); Rachelle Prantil-Baun (Cambridge, Massachusetts); Kambez Hajipouran Benam (Cambridge, Massachusetts); Melissa Rodas (Cambridge, Massachusetts); Ratnakar Potla (Cambridge, Massachusetts); Donald E. Ingber (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein, in some aspects, are combination therapies for inhibiting influenza virus infection. |
| FILED | Thursday, April 30, 2020 |
| APPL NO | 17/608452 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/245 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193029 | Wender et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul Wender (Stanford, California); Akira J. Shimizu (Stanford, California); Clayton Hardman (Stanford, California) |
| ABSTRACT | Provided herein is the use of bryostatin agents to selectively enhance expression, translocation and/or cell surface presentation of an antigen in target cells of interest to modulate immunogenicity of the target cells. Aspects of the methods include, administering an effective amount of a bryostatin agent to a subject to modulate immunogenicity of target cells. The subject methods include a method of treating cancer, including administering to a subject an effective amount of a bryostatin agent to enhance cell surface antigen or neoantigen presentation on target cells of the subject, and administering to the subject a therapeutically effective amount of a therapeutic agent that specifically binds the cell surface antigen to treat the subject for cancer. Aspects of the subject methods also include use of the bryostatin agents to sensitize the target cells to clearance by the subject's immune system. |
| FILED | Tuesday, May 19, 2020 |
| APPL NO | 17/599207 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/365 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193034 | Sibley et al. |
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| FUNDED BY |
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| APPLICANT(S) | WASHINGTON UNIVERSITY (CAMBRIDGE, Missouri); THE BROAD INSTITUTE, INC. (CAMBRIDGE, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (CAMBRIDGE, Massachusetts) |
| ASSIGNEE(S) | WASHINGTON UNIVERSITY (ST. LOUIS, Missouri); THE BROAD INSTITUTE, INC. (CAMBRIDGE, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (CAMBRIDGE, Massachusetts) |
| INVENTOR(S) | Laurence David Sibley (St. Louis, Missouri); Bruno Melillo (Cambridge, Massachusetts); Eamon Comer (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein are compounds useful for the treatment of various parasitic diseases. These compounds, as well as pharmaceutically acceptable salts thereof may be formulated in pharmaceutical compositions, veterinary compositions and may be used in methods of treatment and/or prophylaxis of diseases spread by parasites, including cryptosporidiosis. |
| FILED | Wednesday, April 22, 2020 |
| APPL NO | 17/604732 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/397 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 33/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193038 | Brown et al. |
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| FUNDED BY |
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| APPLICANT(S) | Arisan Therapeutics Inc. (Carlsbad, California) |
| ASSIGNEE(S) | Arisan Therapeutics Inc. (Carlsbad, California) |
| INVENTOR(S) | Eric Brown (Santee, California); Vidyasagar Reddy Gantla (San Diego, California); Nadezda Sokolova (San Diego, California); Michael Bruno Plewe (San Diego, California); Gregory Henkel (Carlsbad, California); Kenneth McCormack (Oceanside, California) |
| ABSTRACT | Compounds as exemplified by compound A are useful in the treatment of arenavirus infections and viral infections mediated by arenavirus glycoproteins. |
| FILED | Tuesday, December 03, 2019 |
| APPL NO | 17/299270 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/437 (20130101) A61K 31/519 (20130101) A61K 31/4184 (20130101) Original (OR) Class A61K 31/4192 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193047 | Stockwell et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brent R. Stockwell (New York, New York); Ling Feng Ye (New York, New York); Simon Cheng (New York, New York) |
| ABSTRACT | The present disclosure provides, inter alia, methods for treating or ameliorating the effects of a cancer in a subject in need thereof by combining a radiosensitizer such as a ferroptosis inducer with radiation. Methods for identifying and treating a subject with a cancer that is resistant to radiotherapy, methods for enhancing the anti-tumor effect of radiation in a subject undergoing radiotherapy, and methods for enhancing the effect of radiation on a cancer cell are also provided. |
| FILED | Wednesday, March 02, 2022 |
| APPL NO | 17/685148 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/436 (20130101) Original (OR) Class A61K 31/517 (20130101) A61K 31/553 (20130101) A61K 31/704 (20130101) A61K 31/4545 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/154 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193056 | Wang et al. |
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| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
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| INVENTOR(S) | Zhenghe Wang (Beachwood, Ohio); Yujun Hao (Shanghai, China PRC); Yamu Li (Cleveland Heights, Ohio) |
| ABSTRACT | A method of treating PIK3CA helical domain mutant cancer in a subject in need thereof includes administering to the subject therapeutically effective amounts of (i) an inhibitor of nuclear translocation of p85β and/or an EZH inhibitor in combination with (ii) a PI3K inhibitor. |
| FILED | Wednesday, December 22, 2021 |
| APPL NO | 17/559280 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4439 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193080 | Li et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of the Sciences (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | University of the Sciences (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Zhijun Li (Bala Cynwyd, Pennsylvania); Tejashree Redij (Warrington, Pennsylvania); James McKee (Havertown, Pennsylvania); Zhiyu Li (Woodstock, Maryland); Jeffrey Campbell (Philadelphia, Pennsylvania) |
| ABSTRACT | The present invention relates to the discovery of small molecule compounds that act as GLP-1R agonists and/or as positive allosteric modulators (PAMs) of GLP-1R. Such compounds are useful to treat, ameliorate, and/or prevent insulin resistance and/or diabetes in a mammal. |
| FILED | Friday, April 10, 2020 |
| APPL NO | 17/602118 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/64 (20130101) A61K 31/155 (20130101) A61K 31/195 (20130101) A61K 31/381 (20130101) A61K 31/426 (20130101) A61K 31/519 (20130101) Original (OR) Class A61K 38/22 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) Heterocyclic Compounds C07D 333/68 (20130101) C07D 495/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193090 | Ashcraft et al. |
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| FUNDED BY |
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| APPLICANT(S) | BioMimetix JV, LLC (Englewood, Colorado); Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kathleen Ashcraft (Durham, North Carolina); Mark Dewhirst (Chapel Hill, North Carolina); Ines Batinic-Haberle (Durham, North Carolina); James D. Crapo (Englewood, Colorado) |
| ABSTRACT | Described herein are methods, compositions, and kits for treating and/or preventing in a subject one or more side effects associated with radiation and/or chemotherapy exposure, including methods, compositions and kits that include an active agent at a low dose. In some embodiments, methods, compositions, and kits for treating and/or preventing tissue damage in a subject are provided, including methods, compositions and kits that include an active agent at a low dose. |
| FILED | Thursday, March 10, 2022 |
| APPL NO | 17/691764 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/555 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193096 | Simard |
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| FUNDED BY |
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| APPLICANT(S) | University of Maryland, Baltimore (Baltimore, Maryland); The United State of America as Represented by the Department Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | J. Marc Simard (Baltimore, Maryland) |
| ABSTRACT | Methods and compositions are provided that are utilized for treatment and/or prevention of intraventricular hemorrhage or progressive hemorrhagic necrosis (PHN), particularly following spinal cord injury. In particular, the methods and compositions are inhibitors of a particular NCCa-ATP channel and include, for example, inhibitors of SUR1 and/or inhibitors of TRPM4. Kits for treatment and/or prevention of intraventricular hemorrhage or progressive hemorrhagic necrosis (PHN), particularly following spinal cord injury, are also provided. The present invention also concerns treatment and/or prevention of intraventricular hemorrhage in infants, including premature infants utilizing one or more inhibitors of the channel is provided to the infant, for example to brain cells of the infant. |
| FILED | Monday, December 20, 2021 |
| APPL NO | 17/645239 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/00 (20130101) A61K 31/64 (20130101) Original (OR) Class A61K 31/195 (20130101) A61K 31/198 (20130101) A61K 31/451 (20130101) A61K 31/454 (20130101) A61K 31/4453 (20130101) A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193103 | Huang et al. |
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| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Leaf Huang (Chapel Hill, North Carolina); Huan Xu (Chapel Hill, North Carolina) |
| ABSTRACT | Disclosed are nanoemulsions comprising puerarin and methods of their use in treating cancer, including breast cancer and melanoma. The presently disclosed puerarin-containing nanoemulsions regulate the tumor microenvironment and importantly de-activate tumor associated fibroblasts (TAFs) rather than killing them. The presently disclosed methods can be used in combination with chemotherapy, e.g., polymer formulations of paclitaxel, or PD-L1 blockade therapy to treat cancer. |
| FILED | Thursday, April 23, 2020 |
| APPL NO | 17/605377 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1075 (20130101) A61K 31/337 (20130101) A61K 31/7048 (20130101) Original (OR) Class A61K 39/3955 (20130101) A61K 47/18 (20130101) A61K 47/24 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193105 | BHUIYAN et al. |
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| FUNDED BY |
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| APPLICANT(S) | Mohuddin Quadair (Fargo, North Dakota); Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| ASSIGNEE(S) | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana); Mohuddin Quadair (Fargo, North Dakota) |
| INVENTOR(S) | Shenuarin BHUIYAN (Shreveport, Louisiana); Mohuddin QUADAIR (Fargo, North Dakota) |
| ABSTRACT | The presently disclosed invention relates to products and methods of treating cancer in a patient comprising administering to the patient a pharmaceutically therapeutic dose of a chemotherapeutic, or any pharmaceutically acceptable salt, solvate, or prodrug thereof, conjugated to a nanocarrier. According to a further embodiment, the chemotherapeutic has a primary (10) amine (—NH2) group in within a pharmaceutical structure of the chemotherapeutic structure. According to a further embodiment, the chemotherapeutic is one of a platinum-based pharmaceutical and an Anthracycline family pharmaceutical. According to a further embodiment, the chemotherapeutic is one of gemcitabine, methotrexate, cisplatin, oxaliplatin, doxorubicin, daunorubicine, idarubicine, and epirubicine. According to a further embodiment, the chemotherapeutic is either attached to the nanocarrier by means that includes covalent bonds or is attached by means that does not included covalent bonds. According to a further embodiment, the nanocarrier is a pH-sensitive nanocarrier. |
| FILED | Monday, March 01, 2021 |
| APPL NO | 17/188891 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/282 (20130101) A61K 31/519 (20130101) A61K 31/704 (20130101) A61K 31/7068 (20130101) Original (OR) Class A61K 33/243 (20190101) A61K 47/60 (20170801) A61K 47/545 (20170801) A61K 47/593 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193106 | Cui et al. |
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| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
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| INVENTOR(S) | Zhengrong Cui (Austin, Texas); Dharmika Lansakara-P. (Austin, Texas) |
| ABSTRACT | Disclosed herein are derivatives of nucleobase analogues. The disclosed compounds have a nucleobase moiety and an omega-3 polyunsaturated fatty acid moiety, including pharmaceutically acceptable salt or prodrug thereof. Methods of using these compounds for the treatment of cancers such as pancreatic cancer are also disclosed. |
| FILED | Monday, March 14, 2022 |
| APPL NO | 17/539682 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7068 (20130101) Original (OR) Class A61K 47/542 (20170801) Heterocyclic Compounds C07D 401/04 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 19/073 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193114 | FALLON et al. |
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| FUNDED BY |
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| APPLICANT(S) | Brown University (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Justin R. FALLON (Providence, Rhode Island); Ashley E. WEBB (Providence, Rhode Island); Beth McKECHNIE (Attleboro, Massachusetts); Tali SORETS (Newton, Massachusetts); Lauren FISH (East Greenwich, Rhode Island); Diego JAIME (Providence, Rhode Island); John PAGE (Storrs, Connecticut) |
| ABSTRACT | Methods and compositions for increasing neurogenesis and for preventing or treating diseases, disorders or conditions associated with neurodegeneration, are provided herein. |
| FILED | Friday, April 17, 2020 |
| APPL NO | 17/604279 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0276 (20130101) A01K 2217/075 (20130101) A01K 2227/105 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/7105 (20130101) Original (OR) Class Peptides C07K 16/18 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193117 | Yang et al. |
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| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lily Yang (Atlanta, Georgia); Lei Zhu (Atlanta, Georgia) |
| ABSTRACT | This disclosure relates to hyaluronic acid nanoparticles containing an anticancer agent such as a NADPH oxidase (NOX) inhibitor for targeted delivery to cancerous cells or tumors. In certain embodiments, the nanoparticles are made up of hyaluronic acid conjugated to hydrophobic moieties. In certain embodiments, the hydrophobic moieties are steroid based compounds, such as 5beta-cholanic acid. |
| FILED | Wednesday, April 01, 2020 |
| APPL NO | 17/600935 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5161 (20130101) A61K 31/437 (20130101) A61K 31/728 (20130101) Original (OR) Class A61K 47/6939 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193123 | Ndinguri et al. |
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| FUNDED BY |
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| APPLICANT(S) | Eastern Kentucky University (Richmond, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Margaret Ndinguri (Richmond, Kentucky); Lindsay Cormier (Richmond, Kentucky) |
| ABSTRACT | The conjugation of luteinizing hormone-releasing hormone (LHRH) with activated cisplatin using a malonate linker gives rise to a new Platinum-LHRH conjugate that effectively targets tumor cells that express the LHRH receptor. The Pt-LHRH conjugate may be used in a method for killing or inhibiting the growth of a tumor cell, especially in late state, highly invasive and aggressive stage IV tumors and in reoccurring tumors. |
| FILED | Friday, November 19, 2021 |
| APPL NO | 17/531246 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 33/243 (20190101) Original (OR) Class A61K 47/64 (20170801) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 15/0093 (20130101) Peptides C07K 7/23 (20130101) C07K 19/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193136 | CHEN et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); Seattle Children's Hospital DBA Seattle Children's Research Institute (Seatlle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yvonne Y. CHEN (Los Angeles, California); Eugenia ZAH (Los Angeles, California); Michael C. JENSEN (Seattle, Washington) |
| ABSTRACT | A CD19-OR-CD20 chimeric antigen receptor (CAR) protein construct is provided. Also provided are nucleic acids encoding the CD19-OR-CD20 CAR; and methods of use, e.g. in the treatment of B cell malignancies. The CD19-OR-CD20 CAR of the invention is a bispecific CAR that can trigger T-cell activation upon detection of either CD19 or CD20 (or both). It is a single molecule that confers two-input recognition capability upon human T cells engineered to stably express this CAR. |
| FILED | Wednesday, January 05, 2022 |
| APPL NO | 17/569107 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 38/00 (20130101) Peptides C07K 14/7051 (20130101) C07K 14/70521 (20130101) C07K 14/70596 (20130101) C07K 16/46 (20130101) C07K 16/2803 (20130101) C07K 16/2887 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193149 | Manuel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | City of Hope (Duarte, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edwin Ramos Manuel (Fontana, California); Don J. Diamond (Glendora, California) |
| ABSTRACT | Provided herein are compositions and methods to treat tumors that include attenuated facultative anaerobic bacterium. The bacterium includes a nucleic acid molecule encoding a recombinant extracellular matrix degrading enzyme operably linked to a promoter. |
| FILED | Friday, May 15, 2020 |
| APPL NO | 17/611393 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/74 (20130101) Original (OR) Class A61K 38/14 (20130101) A61K 38/50 (20130101) A61K 38/212 (20130101) A61K 45/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/52 (20130101) C12N 9/2474 (20130101) C12N 15/11 (20130101) C12N 15/74 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193151 | CHATILA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts); THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts); THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts) |
| INVENTOR(S) | Talal A. CHATILA (Belmont, Massachusetts); Azza ABDEL-GADIR (Cambridge, Massachusetts); Emmanuel STEPHEN VICTOR (Mysuru, India); Rima RACHID (Belmont, Massachusetts); Lynn BRY (Jamaica Plain, Massachusetts); Georg GERBER (Newton, Massachusetts) |
| ABSTRACT | Disclosed are methods and compositions for the prevention and treatment of dysbiosis and associated conditions. In particular, described herein are microbial consortia, including monotherapies or minimal microbial consortia, that can prevent and/or cure dysbiosis and associated conditions. In certain embodiments, the therapy comprises Subdoligranulum variabile. In certain embodiments, the microbial consortia comprise certain members of the taxa Clostridiales, Bacteroidetes, Prevotella, and/or Parabacteroides. |
| FILED | Thursday, March 26, 2020 |
| APPL NO | 17/442904 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/741 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/14 (20180101) A61P 37/08 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193153 | Hu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trustees of Tufts College (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Linden Hu (Sharon, Massachusetts); Louis Cornacchione (Cambridge, Massachusetts) |
| ABSTRACT | Disclosed herein are compositions and methods for treating periodontal disease. |
| FILED | Wednesday, March 18, 2020 |
| APPL NO | 17/440747 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/74 (20130101) A61K 35/744 (20130101) Original (OR) Class A61K 2035/115 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/02 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/205 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193160 | Hatfull et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Graham F. Hatfull (Pittsburgh, Pennsylvania); Carlos Andres Guerrero (Pittsburgh, Pennsylvania); Rebekah Marie Dedrick (Glenshaw, Pennsylvania) |
| ABSTRACT | Disclosed herein are compositions comprising bacteriophages and methods of using these compositions for treating NTM infections. The present disclosure also provides compositions for screening bacteriophages that are effective in treating NTM infections and methods of using the same. |
| FILED | Tuesday, March 08, 2022 |
| APPL NO | 17/689096 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/76 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193166 | ARCHIBONG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Meharry Medical College (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anthony E. ARCHIBONG (Antioch, Tennessee); G. William BATES (Brentwood, Tennessee); Elochukwu J. Ezekakpu (Nashville, Tennessee); Lorin W. SIMON (Antioch, Tennessee); James E.K. Hildreth (Nashville, Tennessee) |
| ABSTRACT | Artificial cervical fluid is disclosed that contains a mucilaginous extract from the okra plant. The mucilaginous extract can be produced using a hot aqueous extractant or cold extraction process followed by separation of larger particles from the extract. The extract finds many uses, for example as a sperm storage medium, a sperm freezing medium, a sexual lubricant, an artificial insemination medium, and an in vitro fertilization medium. |
| FILED | Tuesday, December 28, 2021 |
| APPL NO | 17/563350 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/021 (20130101) A01N 1/0221 (20130101) Diagnosis; Surgery; Identification A61B 17/43 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 6/04 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/0034 (20130101) A61K 36/185 (20130101) Original (OR) Class A61K 2236/33 (20130101) A61K 2236/39 (20130101) A61K 2236/53 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 15/08 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/061 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193181 | Singh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (Charleston, South Carolina) |
| ASSIGNEE(S) | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (Charleston, South Carolina) |
| INVENTOR(S) | Inderjit Singh (Mount Pleasant, South Carolina); Avtar K. Singh (Mount Pleasant, South Carolina) |
| ABSTRACT | The present disclosure provides methods for the treatment or prevention of SARS-Cov-2 infection or disease and IL-6 mediated immune/autoimmune and cancers by the administration of GSNO or GSNO reductase inhibitor. |
| FILED | Tuesday, December 21, 2021 |
| APPL NO | 17/557628 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/198 (20130101) A61K 31/4178 (20130101) A61K 38/28 (20130101) A61K 38/063 (20130101) Original (OR) Class A61K 38/215 (20130101) A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193193 | Spiegelman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bruce M. Spiegelman (Waban, Massachusetts); Katrin J. Svensson (Palo Alto, California) |
| ABSTRACT | The present invention relates to methods for identifying, assessing, preventing, and treating metabolic disorders and modulating metabolic processes using Slit2. |
| FILED | Monday, February 28, 2022 |
| APPL NO | 17/682454 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 38/1709 (20130101) Original (OR) Class Peptides C07K 14/705 (20130101) C07K 14/4702 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5023 (20130101) G01N 2333/4703 (20130101) G01N 2500/04 (20130101) G01N 2500/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193197 | WITTRUP et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karl Dane WITTRUP (Chestnut Hill, Massachusetts); Jennifer R. COCHRAN (Stanford, California); Byron Hua KWAN (Seattle, Washington) |
| ABSTRACT | The present invention provides a method of treating cancer with a combination of IL-2 and an integrin-binding-Fc fusion protein. The methods of the invention can be applied to a broad range of cancer types. |
| FILED | Thursday, August 19, 2021 |
| APPL NO | 17/407011 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/16 (20130101) A61K 38/179 (20130101) A61K 38/385 (20130101) A61K 38/2013 (20130101) Original (OR) Class A61K 39/3955 (20130101) A61K 39/39558 (20130101) A61K 45/06 (20130101) A61K 47/64 (20170801) A61K 2039/505 (20130101) Peptides C07K 14/55 (20130101) C07K 16/22 (20130101) C07K 16/28 (20130101) C07K 16/30 (20130101) C07K 16/40 (20130101) C07K 16/249 (20130101) C07K 16/2803 (20130101) C07K 16/2812 (20130101) C07K 16/2815 (20130101) C07K 16/2818 (20130101) C07K 16/3053 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193204 | CRUZ et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BAYLOR COLLEGE OF MEDICINE (Houston, Texas) |
| ASSIGNEE(S) | BAYLOR COLLEGE OF MEDICINE (Houston, Texas) |
| INVENTOR(S) | Miguel Angel CRUZ (Pearland, Texas); Trung NGUYEN (Houston, Texas) |
| ABSTRACT | Embodiments of the disclosure encompass methods and compositions for maintaining a healthy fibrin network in an individual. The disclosure includes methods of targeting fibrin in an individual for the purpose of restoring fibrin that is subject to a level of fibrinolysis that is deleterious, such as excessive or reduced with respect to the general population. Such modifications of fibrin in an individual may include direct targeting of fibrin with the A2 domain of von Willebrand factor or a functional derivative or fragment thereof. In specific embodiments, the methods restore to a normal level any imbalance between coagulation and inflammation. |
| FILED | Thursday, May 14, 2020 |
| APPL NO | 17/595245 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/19 (20130101) A61K 31/155 (20130101) A61K 31/401 (20130101) A61K 31/436 (20130101) A61K 31/519 (20130101) A61K 31/553 (20130101) A61K 31/704 (20130101) A61K 31/5025 (20130101) A61K 31/7052 (20130101) A61K 31/7056 (20130101) A61K 38/36 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193209 | Gracia et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The J. David Gladstone institutes, a testamentary trust established under the Will of j. David Glads (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Albert Vallejo Gracia (San Francisco, California); Emilie Besnard (San Francisco, California); Melanie Ott (Mill Valley, California); Eric Verdin (San Francisco, California) |
| ABSTRACT | The present disclosure provides compositions and methods for reactivating latent immunodeficiency virus. The present disclosure provides compositions and methods for treating an immunodeficiency virus infection. |
| FILED | Thursday, January 16, 2020 |
| APPL NO | 17/424453 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/55 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193220 | Ma et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Kansas State University Research Foundation (Manhattan, Kansas); Centers for Disease Control and Prevention (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wenjun Ma (Manhattan, Kansas); Liping Wang (Manhattan, Kansas); Suxiang Tong (Atlanta, Georgia) |
| ABSTRACT | An immunogenic composition for reducing the incidence or severity of subclinical and clinical signs of orthoreovirus infection is provided. The composition(s) includes at least one segment or portion thereof of orthoreovirus that is derived from a different serotype, host, or strain than at least one other segment or portion thereof. The present disclosure also provides methods for treating, preventing, and reducing the subclinical and clinical signs of orthoreovirus infection in a subject or group of subjects. |
| FILED | Monday, May 04, 2020 |
| APPL NO | 17/594921 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class A61K 2039/53 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193224 | Oomens |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Regents for the Oklahoma Agricultural and Mechanical Colleges (Stillwater, Oklahoma) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Antonius Oomens (Stillwater, Oklahoma) |
| ABSTRACT | Respiratory syncytial virus (RSV)-based virus-like particles are disclosed. Also disclosed are polynucleotides encoding the virus-like particles (VLPs) as well as immunogenic compositions, pharmaceutical compositions, vaccines, and kits containing the virus-like particles. In addition, methods of producing and using each of the above compositions are also disclosed. Methods of use include single or combination administration of the RSV-VLPs, as well as use of the RSV-VLPs alone or in combination with other types of vaccines. |
| FILED | Tuesday, December 21, 2021 |
| APPL NO | 17/557887 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/155 (20130101) Original (OR) Class A61K 2039/5254 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) A61P 37/04 (20180101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193227 | Cohen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Jeffrey I. Cohen (Bethesda, Maryland); Lesley Pesnicak (Stafford, Virginia) |
| ABSTRACT | The disclosure provides recombinant herpes virus with diminished latency. In embodiments, the recombinant herpes virus comprises a latency gene or transcript linked to an altered or heterologous promoter. The disclosure also provides compositions and methods for inducing immunity in animals using the recombinant herpes viruses. |
| FILED | Friday, March 11, 2022 |
| APPL NO | 17/692540 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/25 (20130101) Original (OR) Class A61K 39/245 (20130101) A61K 2039/5254 (20130101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193240 | Traverso et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Carlo Giovanni Traverso (Newton, Massachusetts); Jinyao Liu (Shanghai, China PRC); Robert S. Langer (Newton, Massachusetts) |
| ABSTRACT | Triggerable hydrogel compositions and related methods are generally disclosed. In some embodiments, the compositions and related methods may be used for medical-related or other applications. For example, the compositions and methods described herein may be useful, for example, in biomedical applications such as articles for (e.g., gastric) retention. In some embodiments, methods for deploying and/or removing an article comprising the composition, such as an article for gastric retention, are provided. The article and/or composition may be removed internally from a subject by, for example, introducing at least one reagent (e.g., one reagent, two reagents) such that at least a portion of the composition disassociates. In certain embodiments, the composition comprises a polymer network comprising two or more interpenetrating polymers. In some cases, a first polymer comprises a first cross-link moiety configured to dissociate upon interaction with a reagent. For example, the composition may be administered to a subject such that it is retained at a location internal (e.g., gastric) to the subject. In some embodiments, a reagent may be administered to the subject (e.g., the subject drinks the reagent) such that the reagent interacts with the composition and at least a first cross-link moiety disassociates. In some embodiments, upon disassociation of one or more cross-link moieties of the polymer network, the composition is no longer retained at the location internal to the subject (e.g., dissociates such that it exits the subject). In some cases, the polymer network is configured (e.g., upon administration of the composition to a subject) such that the composition is retained at the location internal to the subject for greater than or equal to 24 hours. |
| FILED | Wednesday, December 22, 2021 |
| APPL NO | 17/558867 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/0065 (20130101) A61K 9/4816 (20130101) A61K 47/32 (20130101) A61K 47/36 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193242 | Shokat et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevan M. Shokat (San Francisco, California); Ziyang Zhang (San Francisco, California) |
| ABSTRACT | Disclosed herein, inter alia, are immunophilin binding compounds and methods of using the same. |
| FILED | Thursday, February 06, 2020 |
| APPL NO | 17/428080 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/55 (20170801) Original (OR) Class A61K 47/64 (20170801) A61K 47/545 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193248 | Law et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cornell University (Ithaca, New York); Tu Therapeutics Inc. (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benedict Law (New York, New York); Vanessa Bellat (New York, New York); Benjamin Byung-min Choi (Englewood Cliffs, New Jersey) |
| ABSTRACT | The present disclosure relates to a systemically administered peptide delivery platform that biodistributes to the kidney or urinary tract. The disclosure further relates to methods of treating a disease of the kidney or urinary tract in a subject in need thereof. |
| FILED | Monday, December 20, 2021 |
| APPL NO | 17/556714 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) A61K 47/65 (20170801) Original (OR) Class A61K 47/183 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 13/10 (20180101) A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193265 | REH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF WASHINGTON (SEATTLE, Washington) |
| ASSIGNEE(S) | UNIVERSITY OF WASHINGTON (SEATTLE, Washington) |
| INVENTOR(S) | Thomas A. REH (SEATTLE, Washington); Nikolas L. JORSTAD (SEATTLE, Washington); Levi TODD (SEATTLE, Washington) |
| ABSTRACT | Nucleic acid molecules and compositions, and methods using the same are provided herein for intraocular gene-based delivery and expression of two or more proneural bHLH transcription factors in the retina. The nucleic acid molecules, compositions and methods disclosed herein stimulate regeneration of retinal interneurons from retinal Müller glia (MG) and reprogram the MG into bipolar, amacrine, horizontal, and/or ganglion cells. Such methods and nucleic acid molecules are used for vision restoration and/or treatment of a range of ocular diseases involving retinal degeneration after injury, disease, or vison loss. |
| FILED | Wednesday, April 29, 2020 |
| APPL NO | 17/594661 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) A61K 48/0058 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/62 (20130101) C12N 15/86 (20130101) C12N 2740/15043 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193271 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas D. Wang (Ann Arbor, Michigan); Juan Zhou (Ann Arbor, Michigan) |
| ABSTRACT | The disclosure provides peptides, including labeled peptides, that selectively bind to the cMet protein. The disclosure also provides methods of detecting dysplastic cells and tissue, e.g., in the colon, providing early identification of precancerous and cancerous tissue. |
| FILED | Friday, February 21, 2020 |
| APPL NO | 17/432070 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/0032 (20130101) A61K 49/0043 (20130101) A61K 49/0056 (20130101) Original (OR) Class Peptides C07K 7/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193275 | Bradbury et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Memorial Sloan Kettering Cancer Center (New York, New York); Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michelle S. Bradbury (New York, New York); Steven Saeid Zanganeh (New York, New York); Brian Madajewski (New York, New York); Luis Felipe Campesato (New York, New York); Taha Marghoub (Jersey City, New Jersey); Michael Overholtzer (Glen Ridge, New Jersey); Michael R. McDevitt (New York, New York); Ulrich Wiesner (Ithaca, New York) |
| ABSTRACT | Described herein are methods of treating cancer by inducing favorable effects on tumor microenvironment (e.g., including macrophage polarization, cytokine profile, and/or immunophenotype) via administration of nanoparticles (e.g., silica-based ultra-small nanoparticles and nanoparticle conjugates such as nanoparticle drug conjugates). In certain embodiments, the methods may be used in concert with, or as part of, checkpoint inhibition therapy (e.g., anti-PD1) or radiotherapy, or a combination of both radiotherapy and checkpoint inhibitor therapy. |
| FILED | Tuesday, December 17, 2019 |
| APPL NO | 17/414414 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1611 (20130101) A61K 9/5031 (20130101) A61K 31/245 (20130101) A61K 31/499 (20130101) A61K 38/217 (20130101) A61K 38/2013 (20130101) A61K 39/3955 (20130101) A61K 51/088 (20130101) A61K 51/0478 (20130101) A61K 51/0482 (20130101) A61K 51/1244 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193305 | Raia et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicole Raia (Maynard, Massachusetts); David L. Kaplan (Medford, Massachusetts); Chiara E. Ghezzi (Lexington, Massachusetts) |
| ABSTRACT | The present disclosure relates to biocompatible injectable compositions. The provided compositions comprise or consist of silk fibroin, hyaluronic acid, horseradish peroxidase, hydrogen peroxide, and water. The injectable composition is tunable and may be adapted to have a gelation time from 3 minutes to 20 minutes, a storage modulus of 6 Pa to 4000 Pa, be injectable through a needle having a size from 32 G to 18 G, have optical transmittance from 75% to 95% for at least one wavelength from 400 nm to 700 nm, have a volume expansion from 5% to 400% relative to an original volume of the hydrogel after soaking in an aqueous solution for 12 hours, and/or have a hydrogel stability by maintaining at least 75% of the storage modulus and the optical transmittance of the hydrogel after 6 months in vivo. The present disclosure provides methods for making and using the same. |
| FILED | Monday, March 30, 2020 |
| APPL NO | 17/593965 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/26 (20130101) Original (OR) Class A61L 27/52 (20130101) A61L 2400/06 (20130101) A61L 2430/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193386 | Falo, JR. et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Louis D. Falo, JR. (Wexford, Pennsylvania); Geza Erdos (Wexford, Pennsylvania); O. Burak Ozdoganlar (Sewickley, Pennsylvania) |
| ABSTRACT | A method of forming a microneedle array can include forming a microneedle array having one or more chemotherapeutic agents. The microneedle array can include a base portion and plurality of microneedles extending from the base portion, and the one or more chemotherapeutic agents can be present in a higher concentration in the plurality of microneedles than in the base portion. |
| FILED | Friday, January 14, 2022 |
| APPL NO | 17/576141 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0021 (20130101) A61K 31/704 (20130101) A61K 31/713 (20130101) A61K 45/06 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 37/0015 (20130101) Original (OR) Class A61M 2037/0023 (20130101) A61M 2037/0053 (20130101) A61M 2037/0061 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 41/003 (20130101) B29C 41/12 (20130101) B29C 41/22 (20130101) B29C 41/34 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2995/006 (20130101) B29K 2995/0056 (20130101) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2009/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193410 | Galor |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States Government As Represented By The Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anat Galor (Miami, Florida) |
| ABSTRACT | The disclosure relates to methods of treating or reducing ocular pain in a subject. The method includes stimulating nasal tissue in a subject in need of treatment. Optionally, the method can be performed using a stimulator probe having first and second nasal insertion prongs having respective electrodes that can be positioned adjacent to a septum of the subject. The stimulator probe can be connected to a stimulator body having a control subsystem to control an electrical stimulus to be delivered to the subject via the stimulator probe. Optionally, the subject does not have low tear volume. |
| FILED | Wednesday, April 08, 2020 |
| APPL NO | 17/602058 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/13 (20130101) A61K 38/2006 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/36021 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193411 | Oliver et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Connecticut (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Douglas L. Oliver (West Hartford, Connecticut); Alice L. Burghard (Wolcott, Connecticut); Christopher Lee (West Hartford, Connecticut); Emily Fabrizio-Stover (Rocky Hill, Connecticut) |
| ABSTRACT | Disclosed is a method. The method may include receiving first data based on a stimulus defined according to a patient. The method may include receiving second data based on the stimulus. The method may include determining an indication of tinnitus. The indication of tinnitus may be based on a comparison between the first data and the second data. The method may include administering a tinnitus treatment on the patient. The treatment may be based on the indication. A tinnitus treatment may include one or more of an biological feedback with the patient, transcranial magnetic stimulation of the patient, surgical insertion of the cochlear implant, the cognitive behavioral therapy, the transcutaneous electrical stimulation, pharmacologic therapy on the patient, or applying a hearing aid to the patient. |
| FILED | Friday, December 17, 2021 |
| APPL NO | 17/554973 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/123 (20130101) A61B 5/128 (20130101) A61B 5/4836 (20130101) A61B 5/7228 (20130101) A61B 5/7235 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0456 (20130101) A61N 1/36036 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193451 | DUVAL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RefleXion Medical, Inc. (Hayward, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eugene DUVAL (Menlo Park, California); Layton HALE (Castro Valley, California); David LARKIN (Menlo Park, California) |
| ABSTRACT | Described herein are multi-leaf collimators that comprise leaf drive mechanisms. The leaf drive mechanisms can be used in binary multi-leaf collimators used in emission-guided radiation therapy. One variation of a multi-leaf collimator comprises a pneumatics-based leaf drive mechanism. Another variation of a multi-leaf collimator comprises a spring-based leaf drive mechanism having a spring resonator. |
| FILED | Thursday, December 30, 2021 |
| APPL NO | 17/566212 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/1045 (20130101) Original (OR) Class A61N 2005/1074 (20130101) Techniques for Handling Particles or Ionising Radiation Not Otherwise Provided For; Irradiation Devices; Gamma Ray or X-ray Microscopes G21K 1/046 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193457 | Konofagou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (NEW YORK, New York) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (NEW YORK, New York) |
| INVENTOR(S) | Elisa E. Konofagou (New York, New York); Fabrice Marquet (New York, New York); Yao-Sheng Tung (New York, New York) |
| ABSTRACT | Systems and methods for cavitation-guided opening of a targeted region of tissue within a primate skull are provided. In one example, a method includes delivering one or more microbubbles to proximate the targeted region, applying an ultrasound beam, using a transducer, through the skull of the primate to the targeted region to open the tissue, transcranially acquiring acoustic emissions produced from an interaction between the one or more microbubbles and the tissue, and determining a cavitation spectrum from the acquired acoustic emissions. |
| FILED | Wednesday, March 09, 2022 |
| APPL NO | 17/690523 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/481 (20130101) A61B 8/0808 (20130101) A61B 17/2258 (20130101) A61B 2017/00106 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 7/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193660 | Carmona-Fontaine |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NEW YORK UNIVERSITY (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carlos Carmona-Fontaine (Brooklyn, New York) |
| ABSTRACT | The present invention provides a discrete microenvironment chamber (DIMIC) configured to accurately mimics the microenvironment of poorly perfused tissue. In one embodiment, the DIMIC of the present invention is further designed to allow the extraction of cells and media from different local environments for any type of biochemical analysis. |
| FILED | Friday, December 17, 2021 |
| APPL NO | 17/554369 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5027 (20130101) Original (OR) Class B01L 2200/0647 (20130101) Apparatus for Enzymology or Microbiology; C12M 23/16 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0693 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193676 | Karumbaiah |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (Athens, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lohitash Karumbaiah (Bogart, Georgia) |
| ABSTRACT | Described herein is a microfluidic assay device that mimics in vitro the in vivo biological environment, supporting endothelization, allowing for perfusive flow similar to in vivo blood flow conditions, and providing for realistic interactions between T-cells and solid tumor cells, such as glioblastoma multiforme tumor cells. Also described herein are methods of using this microfluidic assay device for the study of interactions of immune cells with tumor cells, such as glioblastoma multiforme tumor cells, and the development of improved immunotherapeutic approaches against cancers, such as glioblastoma multiforme. |
| FILED | Wednesday, April 08, 2020 |
| APPL NO | 17/601745 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502746 (20130101) B01L 3/502761 (20130101) Original (OR) Class B01L 2200/0652 (20130101) B01L 2300/12 (20130101) B01L 2400/086 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5091 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220194888 | CRAWFORD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason CRAWFORD (Shelton, Connecticut); Tyler GODDARD (Cambridge, Massachusetts); Hyun Bong PARK (West Haven, Connecticut); Jaymin PATEL (New Haven, Connecticut) |
| ABSTRACT | Provided herein are novel antibacterial compounds of Formula I. The compounds can be made through enzymatic oxidative dimerization in the presence of a suitable organism and one or more metal salts. Pathogenic bacteria exposed to the compound of Formula I do not develop resistance to these compounds even after prolonged exposure. Also provided herein are methods of treating bacterial infections, and method of killing or disinfecting bacteria. |
| FILED | Friday, April 17, 2020 |
| APPL NO | 17/604908 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 35/06 (20130101) Biocidal, Pest Repellant, Pest Attractant or Plant Growth Regulatory Activity of Chemical Compounds or Preparations A01P 1/00 (20210801) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/02 (20180101) Acyclic or Carbocyclic Compounds C07C 50/28 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220194917 | Thatcher et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | Gregory R. Thatcher (Chicago, Illinois); Rui Xiong (Urbana, Illinois); Jiong Zhao (Urbana, Illinois); Debra A. Tonetti (Urbana, Illinois) |
| ABSTRACT | This invention is benzothiophene-based estrogen receptor downregulators and their compositions and uses to treat estrogen-related medical disorders. |
| FILED | Monday, July 26, 2021 |
| APPL NO | 17/385748 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/10 (20180101) A61P 35/00 (20180101) Heterocyclic Compounds C07D 333/64 (20130101) Original (OR) Class C07D 409/06 (20130101) C07D 409/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220194930 | SADEGHI et al. |
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| FUNDED BY |
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| APPLICANT(S) | Yale University (New Haven, Connecticut); The United States of America as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mehran SADEGHI (Easton, Connecticut); Yunpeng YE (Staten Island, New York); Hye-Yeong KIM (Hamden, Connecticut); Henry(Yiyun) HUANG (Madison, Connecticut); Jakub TOCZEK (New Haven, Connecticut) |
| ABSTRACT | The present invention provides certain compounds, or salts or solvates thereof, which can be used as matrix metalloproteinase-targeted inhibitors or imaging agents. |
| FILED | Friday, March 11, 2022 |
| APPL NO | 17/693011 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/044 (20130101) Heterocyclic Compounds C07D 273/01 (20130101) C07D 413/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220194932 | Capobianco et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MIAMI (Miami, Florida); STEM SYNERGY THERAPEUTICS, INC. (Miami, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anthony J. Capobianco (Miami Beach, Florida); Mark Spyvee (Hampstead, New Hampshire); Luisana Astudillo (North Miami, Florida); Darren Orton (Miami, Florida) |
| ABSTRACT | Disclosed herein are inhibitors of the Notch transcriptional activation complex, and methods for their use in treating or preventing diseases, such as cancer. The inhibitors described herein can include compounds of Formula (I) and pharmaceutically acceptable salts thereof: Formula (I), wherein the substituents are as described. |
| FILED | Tuesday, February 11, 2020 |
| APPL NO | 17/602311 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 403/12 (20130101) C07D 417/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220194937 | Cuny et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Houston System (Houston, Texas); Trustees of Tufts College (Medford, Massachusetts); Institute for Cancer Research d/b/a The Research Institute of Fox Chase Cancer Center (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregory Cuny (Houston, Texas); Alexei Degterev (Brookline, Massachusetts); Sameer Nikhar (Nashville, Tennessee); Siddharth Balachandran (Elkins Park, Pennsylvania) |
| ABSTRACT | Identified compounds demonstrate protein kinase inhibitory activity. More specifically, the compounds are demonstrated to inhibit receptor interacting kinase 2 (RIPK2) and/or Activin-like kinase 2 (ALK2) and/or receptor interacting kinase 3 (RIPK3). Compounds that are either dual RIPK2/ALK2 inhibitors or that preferentially inhibit RIPK2 or ALK2 or RIPK3 could provide therapeutic benefit. Compounds that function as RIPK3 inhibitors provide therapeutic benefit in the treatment of inflammatory and degenerative conditions. |
| FILED | Thursday, May 14, 2020 |
| APPL NO | 17/595406 |
| CURRENT CPC | Heterocyclic Compounds C07D 471/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220194939 | Dugar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Colorado Research Partners, LLC (Centennial, Colorado); The Regents of the University of Colorado, A Body Corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sundeep Dugar (Centennial, Colorado); Chase Needham (Wilmington, North Carolina); Paul Maffuid (Carlsbad, California); Rajendra Kumar Reddy Gadikota (Wilmington, North Carolina); Sreenivasulu Reddy Koduru (Wilmington, North Carolina); Michael F. Wempe (Aurora, Colorado); Vijay Kumar (Aurora, Colorado) |
| ABSTRACT | Disclosed herein are novel compounds that inhibit fructokinase (KHK or ketohexokinase) and the downstream metabolic effects mediated by fructose metabolism. Fructokinase inhibitors specifically block the metabolism of both dietary and endogenous fructose metabolism and have a host of potential metabolic benefits. |
| FILED | Friday, April 17, 2020 |
| APPL NO | 17/603988 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Heterocyclic Compounds C07D 231/56 (20130101) C07D 249/18 (20130101) C07D 401/12 (20130101) C07D 403/12 (20130101) C07D 471/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220194943 | Tosato et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Servi (Bethesda, Maryland); Johann Wolfgang Goethe-Universität (Frankfurt am Main, Germany); Deutsches Krebsforschungszentrum (Heidelberg, Germany) |
| ASSIGNEE(S) | THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland); Johann Wolfgang Goethe-Universität (Frankfurt am Main, Germany); Deutsches Krebsforschungszentrum (Heidelberg, Germany) |
| INVENTOR(S) | Giovanna Tosato (Bethesda, Maryland); Michael J. DiPrima (Silver Spring, Maryland); Harald Schwalbe (Frankfurt, Germany); Alix Tröster (Frankfurt, Germany); Denis Kudlinzki (Heidelberg, Germany); Nathalie Jores (Frankfurt, Germany) |
| ABSTRACT | Ephrin type receptor tyrosine kinase inhibitors, also known as Eph tyrosine kinase receptor inhibitors, for treating cancer, an inflammatory disease, an autoimmune disease, or a degenerative disease characterized at least in part by the abnormal activity or expression of the Eph receptor tyrosine kinase. The inhibitors are particularly useful for treating certain cancers. |
| FILED | Friday, March 11, 2022 |
| APPL NO | 17/692978 |
| CURRENT CPC | Heterocyclic Compounds C07D 401/14 (20130101) C07D 403/14 (20130101) C07D 413/14 (20130101) C07D 473/34 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220194952 | PANDEY et al. |
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| FUNDED BY |
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| APPLICANT(S) | Health Research, Inc. (Buffalo, New York); The Research Foundation for The State University of New York (Amherst, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ravindra K. PANDEY (East Amherst, New York); Mykhaylo DUKH (Buffalo, New York); Aimee MARKO (Buffalo, New York); Munawwar SAJJAD (Amherst, New York) |
| ABSTRACT | Compounds for tumor imaging (e g , magnetic resonance (MR) and fluorescence) that may be used in combination with other methods to treat an individual having or suspected of having cancer (e.g., various forms of cancer, such as, for example, solid tumors). Compounds may have the following structure: (I) or a salt, a partial salt, a hydrate, a polymorph, an isomer (e.g., a structural or stereoisomer), or a mixture thereof, where R′ is an aryl group or heteroaryl group having a halogen group (e.g., I or 124I), X is chosen from O, S, or NH, n is 1-6 (e.g., 1, 2, 3, 4, 5, or 6), the dotted carbon is chiral and is R or S. |
| FILED | Wednesday, March 25, 2020 |
| APPL NO | 17/442905 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 41/0071 (20130101) A61K 49/0036 (20130101) Heterocyclic Compounds C07D 487/22 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220194985 | Moellering et al. |
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| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | The University of Chicago (Chicago, Illinois) |
| INVENTOR(S) | Raymond E. Moellering (Chicago, Illinois); Jeffrey E. Montgomery (Chicago, Illinois) |
| ABSTRACT | The present disclosure provides macrocyclic and macrobicyclic peptides with secondary structures that are stabilized over the corresponding non-cyclic peptides. The macrocyclic and macrobicyclic peptides are formed from peptides with adduct-forming, complementary reactive side chain moieties. |
| FILED | Thursday, April 09, 2020 |
| APPL NO | 17/602044 |
| CURRENT CPC | Peptides C07K 1/04 (20130101) C07K 1/10 (20130101) C07K 7/50 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220194987 | SCOTT et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida); BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Luisa Lynn SCOTT (Austin, Texas); Joseph Paul WALTON (Tampa, Florida) |
| ABSTRACT | The present invention concerns peptides and nucleic acids encoding the peptides, and their use for modulating large conductance Ca2+ activated K+ (BK) channel activity in cells; for treating conditions such as presbycusis (age-related hearing loss), audiogenic seizures, alcohol addiction, cancer, and neurodegenerative disease; and for delivering a cargo moiety to the brain of a subject through the blood-brain barrier. |
| FILED | Tuesday, January 04, 2022 |
| APPL NO | 17/568619 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 7/06 (20130101) C07K 7/54 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220194990 | Gendelman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Howard E. Gendelman (Omaha, Nebraska); Jonathan Herskovitz (Omaha, Nebraska); Mahmudul Hasan (Omaha, Nebraska); Bhavesh Kevadiya (omaha, Nebraska) |
| ABSTRACT | The present invention provides virus-like particles and methods of manufacture and use thereof. In accordance with the instant invention, virus-like particles (VLPs), particularly human immunodeficiency virus (HIV) VLPs, are provided. The HIV VLPs comprise at least one HIV structural protein and the HIV envelope protein, but lacks the HIV genome and lacks functional reverse transcriptase and integrase. |
| FILED | Friday, January 31, 2020 |
| APPL NO | 17/310245 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2740/16022 (20130101) C12N 2740/16023 (20130101) C12N 2740/16042 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220194992 | Samulski |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard Jude Samulski (Chapel Hill, North Carolina) |
| ABSTRACT | Disclosed herein are methods and compositions comprising an adeno-associated vims 2.5 (AAV2.5) capsid protein, comprising one or more amino acids substitutions, wherein the substitutions introduce a new glycan binding site into the AAV capsid protein. |
| FILED | Thursday, April 23, 2020 |
| APPL NO | 17/605124 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/0058 (20130101) Peptides C07K 14/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2750/14122 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195001 | Deslouches et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH – OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Berthony Deslouches (Pittsburgh, Pennsylvania); Yuanpu Di (Wexford, Pennsylvania) |
| ABSTRACT | This disclosure is directed to compositions comprised of antimicrobial peptides (AMPs) having an alpha helical structure wherein one side is highly hydrophobic. Representative sequences of the antimicrobial peptides include ILKKWWββαβGLLGβLLGαVββVIKβLββI (SEQ ID No. 2), LKKWWKβαKGLLGGLLGKVββVIK (SEQ ID No. 12), and αKKααKKαKGαLGGLαGK (SEQ ID No. 18). Additional embodiments disclose methods for treating a microbial infection; reducing biofilm; decreasing inflammation; and treating infectious diseases, COPD, asthma, pulmonary fibrosis, cystic fibrosis, rhinosinusitis, septicemia, RSV, TB or cancer; in a subject in need thereof comprising administering to the subject a therapeutic amount of an antimicrobial peptide. |
| FILED | Friday, November 19, 2021 |
| APPL NO | 17/531100 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/4723 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195008 | Robbins et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Paul F. Robbins (Chevy Chase, Maryland); Steven A. Rosenberg (Potomac, Maryland); Shiqui Zhu (Potomac, Maryland); Steven A. Feldman (Redwood City, California); Richard A. Morgan (Center Harbor, New Hampshire) |
| ABSTRACT | The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for a) melanoma antigen family A (MAGE A)-3 in the context of HLA-A1 or b) MAGE-A12 in the context of HLA-Cw7. The invention further provides related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells. Further provided by the invention are antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention. Methods of detecting the presence of cancer in a host and methods of treating or preventing cancer in a host are further provided by the invention. |
| FILED | Thursday, March 10, 2022 |
| APPL NO | 17/691569 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/5158 (20130101) Peptides C07K 14/7051 (20130101) C07K 14/70503 (20130101) Original (OR) Class C07K 16/2803 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) G01N 33/57407 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195015 | Nussenzweig |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Rockefeller University (New York, New York) |
| ASSIGNEE(S) | The Rockefeller University (New York, New York) |
| INVENTOR(S) | Michel Nussenzweig (New York, New York) |
| ABSTRACT | This disclosure provides novel broadly neutralizing anti-SARS-CoV-2 antibodies or antigen-binding fragments thereof. The disclosed anti-SARS-CoV-2 antibodies constitute a novel therapeutic strategy in protection against SARS-CoV-2 infections. |
| FILED | Thursday, November 04, 2021 |
| APPL NO | 17/519173 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/42 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/10 (20130101) Original (OR) Class C07K 2317/31 (20130101) C07K 2317/76 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195025 | Lee et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GENZYME CORPORATION (Cambridge, Massachusetts); Baylor College of Medicine (Houston, Texas) |
| ASSIGNEE(S) | GENZYME CORPORATION (Cambridge, Massachusetts); Baylor College of Medicine (Houston, Texas) |
| INVENTOR(S) | Brendan Lee (Houston, Texas); Kuber T. Sampath (Holliston, Massachusetts) |
| ABSTRACT | The present invention provides methods for treating and improving the symptoms of osteogenesis imperfecta (OI) in a subject by administering to the subject a therapeutically effective amount of a binding agent that binds to transforming growth factor beta (TGFβ). |
| FILED | Thursday, December 09, 2021 |
| APPL NO | 17/547069 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 33/42 (20130101) A61K 39/3955 (20130101) A61K 39/39533 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/22 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195033 | TESTANI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut); Novo Nordisk A/S (New Haven, Denmark) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey TESTANI (Guilford, Connecticut); Veena RAO (Cerby, Connecticut); Rahul KAKKAR (Weston, Massachusetts); Madhav N. DEVALARAJA (Acton, Massachusetts); Chih-Hung LO (Rockville, Maryland) |
| ABSTRACT | The present disclosure provides methods of treating diuretic resistance by administering an IL-6 antagonist to patients who require diuresis. In typical embodiments, the patient has heart failure. Optionally, the patient has elevated urine levels of IL-6, plasma levels of IL-6, or both urine and plasma levels of IL-6. |
| FILED | Thursday, November 04, 2021 |
| APPL NO | 17/519082 |
| CURRENT CPC | Peptides C07K 16/248 (20130101) Original (OR) Class C07K 2317/76 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195172 | Chin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HydroGlyde Coatings LLC (Brookline, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stacy Lee Chin (Brookline, Massachusetts); Benjamin Goldman Cooper (Lynnfield, Massachusetts) |
| ABSTRACT | The invention provides novel polymer formulations and use thereof in surface coatings of various products. More particularly, the invention provides a novel hydrophilic polymer and latex polymer blend coating formulation and compositions thereof, having one or more selected surfactants therein, and their use on various devices (e.g., prophylactic and medical devices) to form hydrophilic and flexible coatings with durable lubricity. |
| FILED | Saturday, March 28, 2020 |
| APPL NO | 17/603446 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 6/04 (20130101) Compositions of Macromolecular Compounds C08L 21/02 (20130101) C08L 39/06 (20130101) Original (OR) Class C08L 2203/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195364 | Sharei et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Armon R. Sharei (Cambridge, Massachusetts); Klavs F. Jensen (Lexington, Massachusetts); James Robbins Abshire (Cambridge, Massachusetts); Jacquin Clarence Niles (Arlington, Massachusetts) |
| ABSTRACT | The current subject matter includes methods, systems, articles, and techniques to deliver material to anucleate cells, such as red blood cells. Using a rapid deformation based microfluidic system, loading of red blood cells with macromolecules of different sizes has been shown. Although delivery to some mammalian cells, such as cancer cell lines and fibroblasts had been previously demonstrated using this technique, those designs were incompatible with RBCs that have dramatically different physical properties. Through the use of smaller constriction sizes, high speeds and different buffers successful delivery to red blood cells can be achieved. By enabling robust delivery to red blood cells in a simple, scalable manner, the current subject matter can be implemented in a diversity of applications that deliver material to study red blood cell diseases and/or use red blood cells as a therapeutic platform. Related apparatus, systems, techniques, and articles are also described. |
| FILED | Tuesday, March 08, 2022 |
| APPL NO | 17/689745 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/18 (20130101) Apparatus for Enzymology or Microbiology; C12M 23/16 (20130101) Original (OR) Class C12M 35/04 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0641 (20130101) C12N 5/0644 (20130101) C12N 15/87 (20130101) C12N 2521/00 (20130101) C12N 2527/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195371 | Schaffer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David V. Schaffer (Danville, California); Nicole Anne Repina (Albany, California); Ruoxing Lei (Berkeley, California); Thomas Patrick C. McClave (Berkeley, California) |
| ABSTRACT | Provided are systems and methods for spatially and temporally controlling light with an illumination device comprising a light source operably connected to a circuit board, one or more light guide plates, one or more optical masks, a controller, and a computer readable medium, comprising instructions that, when executed by the controller, cause the controller to: illuminate a cell or a substrate with light from the light source, and spatially and temporally control illumination of light to the cell or the substrate with one or more illumination parameters, wherein the one or more light guide plates provides uniform illumination of the light. Also provided herein are methods of screening using the system and/or device of the present disclosure. |
| FILED | Thursday, February 10, 2022 |
| APPL NO | 17/669064 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/12 (20130101) C12M 31/08 (20130101) C12M 31/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195387 | Sharfstein et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for the State University of New York (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Susan Sharfstein (Niskayuna, New York); Yubing Xie (Cohoes, New York); Pujhitha Ramesh (Albany, New York); James Castracane (Marshfield, New York); Melinda Larsen (Albany, New York) |
| ABSTRACT | The present disclosure relates to compositions, apparatus and methods for generating one or more scaffolds, including: mixing a hydrogel material and/or an extracellular matrix (ECM) protein in an aqueous solvent to generate an aqueous process solution; and cryoelectrospinning the aqueous process solution onto a plurality of conductive probes extending from a conductive surface of a collector plate disposed within a process chamber under conditions sufficient to generate one or more scaffolds configured to mimic a preselected soft tissue decellularized extracellular matrix. Scaffold compositions are also provided having preselected or tuned characteristics. |
| FILED | Tuesday, December 21, 2021 |
| APPL NO | 17/558543 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0633 (20130101) Original (OR) Class C12N 2513/00 (20130101) C12N 2533/54 (20130101) C12N 2533/72 (20130101) C12N 2533/74 (20130101) C12N 2533/90 (20130101) C12N 2535/00 (20130101) Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/0046 (20130101) Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles D10B 2211/06 (20130101) D10B 2509/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195395 | Childs et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charlie Childs (Ann Arbor, Michigan); Emily Holloway (Ann Arbor, Michigan); Jason Spence (Ann Arbor, Michigan) |
| ABSTRACT | The invention disclosed herein generally relates to methods and systems for improving physiological growth of cultured tissues. In particular, the invention disclosed herein relates to methods and systems for promoting maintenance of cultured intestinal organoids (e.g., derived from pluripotent stem cells or from primary sources such as biopsy tissue). |
| FILED | Monday, December 13, 2021 |
| APPL NO | 17/549028 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0679 (20130101) Original (OR) Class C12N 2501/119 (20130101) C12N 2501/155 (20130101) C12N 2501/415 (20130101) C12N 2506/45 (20130101) C12N 2533/90 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5014 (20130101) G01N 33/5044 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195406 | Gersbach et al. |
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| FUNDED BY |
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| APPLICANT(S) | Duke University (Durnam, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles A. Gersbach (Chapel Hill, North Carolina); Adrian Pickar Oliver (Rougemont, North Carolina) |
| ABSTRACT | Disclosed herein are CRISPR/Cas-based genome editing compositions and methods for treating Duchenne Muscular Dystrophy by restoring dystrophin function. |
| FILED | Tuesday, April 14, 2020 |
| APPL NO | 17/603329 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) A61K 38/465 (20130101) Peptides C07K 14/4708 (20130101) C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/11 (20130101) C12N 15/86 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) C12N 2750/14143 (20130101) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195408 | Raines et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ronald T. Raines (Madison, Wisconsin); Trish Hoang (Madison, Wisconsin) |
| ABSTRACT | The present disclosure provides compositions, methods and kits for the treatment of cancer. Particularly, the present disclosure provides synergistic compositions comprising at least one cytotoxic ribonuclease and at least one MAPK-pathway inhibitor. |
| FILED | Wednesday, March 09, 2022 |
| APPL NO | 17/690886 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class Enzymes C12Y 301/27005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195418 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David R. Liu (Cambridge, Massachusetts); Kevin Michael Esvelt (Cambridge, Massachusetts); Jacob Charles Carlson (Cambridge, Massachusetts) |
| ABSTRACT | The invention provides systems, methods, reagents, apparatuses, vectors, and host cells for the continuous evolution of nucleic acids. For example, a lagoon is provided in which a population of viral vectors comprising a gene of interest replicates in a stream of host cells, wherein the viral vectors lack a gene encoding a protein required for the generation of infectious viral particles, and wherein that gene is expressed in the host cells under the control of a conditional promoter, the activity of which depends on a function of the gene of interest to be evolved. Some aspects of this invention provide evolved products obtained from continuous evolution procedures described herein. Kits containing materials for continuous evolution are also provided. |
| FILED | Friday, December 03, 2021 |
| APPL NO | 17/541848 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/70 (20130101) C12N 15/85 (20130101) C12N 15/86 (20130101) C12N 15/1058 (20130101) Original (OR) Class Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 40/08 (20130101) C40B 50/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195425 | Porteus et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); Agilent Technologies, Inc. (Santa Clara, California) |
| INVENTOR(S) | Matthew H. Porteus (Stanford, California); Ayal Hendel (Stanford, California); Joe Clark (Stanford, California); Rasmus O. Bak (Stanford, California); Daniel E. Ryan (Santa Clara, California); Douglas J. Dellinger (Santa Clara, California); Robert Kaiser (Santa Clara, California); Joel Myerson (Santa Clara, California) |
| ABSTRACT | Provided herein are methods for inducing CRISPR/Cas-based gene regulation (e.g., genome editing or gene expression) of a target nucleic acid (e.g., target DNA or target RNA) in a cell. The methods include using modified single guide RNAs (sgRNAs) that enhance gene regulation of the target nucleic acid in a primary cell for use in ex vivo therapy or in a cell in a subject for use in in vivo therapy. Additionally, provided herein are methods for preventing or treating a genetic disease in a subject by administering a sufficient amount of a modified sgRNA to correct a mutation in a target gene associated with the genetic disease. |
| FILED | Monday, March 14, 2022 |
| APPL NO | 17/694310 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/96 (20130101) C12N 15/11 (20130101) Original (OR) Class C12N 15/111 (20130101) C12N 15/907 (20130101) C12N 2310/10 (20130101) C12N 2310/20 (20170501) C12N 2310/315 (20130101) C12N 2310/321 (20130101) C12N 2310/346 (20130101) C12N 2310/531 (20130101) C12N 2320/51 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195426 | Porteus et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior Univerisity (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior Univerisity (Stanford, California); Agilent Technologies, Inc. (Santa Clara, California) |
| INVENTOR(S) | Matthew H. Porteus (Stanford, California); Ayal Hendel (Stanford, California); Joe Clark (Stanford, California); Rasmus O. Bak (Stanford, California); Daniel E. Ryan (Santa Clara, California); Douglas J. Dellinger (Santa Clara, California); Robert Kaiser (Santa Clara, California); Joel Myerson (Santa Clara, California) |
| ABSTRACT | Provided herein are methods for inducing CRISPR/Cas-based gene regulation (e.g., genome editing or gene expression) of a target nucleic acid (e.g., target DNA or target RNA) in a cell. The methods include using modified single guide RNAs (sgRNAs) that enhance gene regulation of the target nucleic acid in a primary cell for use in ex vivo therapy or in a cell in a subject for use in in vivo therapy. Additionally, provided herein are methods for preventing or treating a genetic disease in a subject by administering a sufficient amount of a modified sgRNA to correct a mutation in a target gene associated with the genetic disease. |
| FILED | Monday, March 14, 2022 |
| APPL NO | 17/694336 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/96 (20130101) C12N 15/11 (20130101) Original (OR) Class C12N 15/111 (20130101) C12N 15/907 (20130101) C12N 2310/10 (20130101) C12N 2310/20 (20170501) C12N 2310/315 (20130101) C12N 2310/321 (20130101) C12N 2310/346 (20130101) C12N 2310/531 (20130101) C12N 2320/51 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195427 | Porteus et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); Agilent Technologies, Inc. (Santa Clara, California) |
| INVENTOR(S) | Matthew H. Porteus (Stanford, California); Ayal Hendel (Stanford, California); Joe Clark (Stanford, California); Rasmus O. Bak (Stanford, California); Daniel E. Ryan (Santa Clara, California); Douglas J. Dellinger (Santa Clara, California); Robert Kaiser (Santa Clara, California); Joel Myerson (Santa Clara, California) |
| ABSTRACT | Provided herein are methods for inducing CRISPR/Cas-based gene regulation (e.g., genome editing or gene expression) of a target nucleic acid (e.g., target DNA or target RNA) in a cell. The methods include using modified single guide RNAs (sgRNAs) that enhance gene regulation of the target nucleic acid in a primary cell for use in ex vivo therapy or in a cell in a subject for use in in vivo therapy. Additionally, provided herein are methods for preventing or treating a genetic disease in a subject by administering a sufficient amount of a modified sgRNA to correct a mutation in a target gene associated with the genetic disease. |
| FILED | Monday, March 14, 2022 |
| APPL NO | 17/694361 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/96 (20130101) C12N 15/11 (20130101) Original (OR) Class C12N 15/111 (20130101) C12N 15/907 (20130101) C12N 2310/10 (20130101) C12N 2310/20 (20170501) C12N 2310/315 (20130101) C12N 2310/321 (20130101) C12N 2310/346 (20130101) C12N 2310/531 (20130101) C12N 2320/51 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195428 | NAAR et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Genera Hospital Corporation (Boston, Massachusetts); The Schepens Eye Research Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anders M. NAAR (Berkeley, California); Patricia D'AMORE (Newton, Massachusetts) |
| ABSTRACT | Disclosed are oligonucleotides, compositions, and methods that may be useful in the treatment of age-related macular degeneration (AMD). The treatment of age-regulated macular degeneration (AMD) may involve inhibiting an miR-33 target nucleic acid. For example, inhibition of an miR-33 target nucleic acid may be achieved using antisense oligonucleotides targeting an miR-33 target nucleic acid, interfering oligonucleotides targeting an miR-33 target nucleic acid, or recombinant AAV particles including a vector encoding an antisense oligonucleotide or interfering oligonucleotide targeting an miR-33 target nucleic acid. |
| FILED | Wednesday, January 29, 2020 |
| APPL NO | 17/310235 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/113 (20130101) C12N 2310/315 (20130101) C12N 2310/3231 (20130101) C12N 2750/14023 (20130101) C12N 2750/14043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195442 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chang C. Liu (Irvine, California); Alon Wellner (Irvine, California); Ziwei Zhong (Irvine, California); Arjun Ravikumar (Irvine, California); Andrew Kruse (Boston, Massachusetts); Conor Thomas McMahon (Brighton, Massachusetts) |
| ABSTRACT | Disclosed herein are methods, compositions, and kits for engineering proteins using error-prone orthogonal replication (epOrthoRep) and yeast surface display (YSD). |
| FILED | Thursday, December 09, 2021 |
| APPL NO | 17/546515 |
| CURRENT CPC | Peptides C07K 2317/569 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1252 (20130101) C12N 15/70 (20130101) Original (OR) Class C12N 15/81 (20130101) C12N 15/102 (20130101) C12N 15/1058 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195449 | Howard et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Applied Biotechnology Institute, Inc. (San Luis Obispo, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Howard (San Luis Obispo, California); Celine Hayden (San Louis Obispo, California); Rafael Jimenez-Flores (San Luis Obispo, California) |
| ABSTRACT | Increased antigenicity of a membrane-bound polypeptide produced from a plant is provided in a process in which extraction of the polypeptide or other compounds from the plant is such that phospholipids are associated with the polypeptide. Reducing fat by supercritical fluid extraction increases antigenicity of such plant-produced membrane-bound polypeptides. Methods and means of producing such membrane-bound polypeptides are provided. Methods to produce a protective response in animals are provided by administering to the animal the membrane-bound polypeptide. Binding of antibody specific to the membrane-bound polypeptide is increased. The process provides for increased preferred formation of the membrane-bound polypeptide. Stability of the membrane-bound polypeptide is increased when the plant material is defatted. |
| FILED | Friday, November 19, 2021 |
| APPL NO | 17/455871 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/21 (20130101) A61K 39/292 (20130101) A61K 2039/517 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8257 (20130101) Original (OR) Class C12N 15/8258 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195457 | DIMIDSCHSTEIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts); NEW YORK UNIVERSITY (New York, New York) |
| ASSIGNEE(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts); NEW YORK UNIVERSITY (New York, New York) |
| INVENTOR(S) | Jordane DIMIDSCHSTEIN (Cambridge, Massachusetts); Gordon FISHELL (Cambridge, Massachusetts); Orrin DEVINSKY (New York, New York) |
| ABSTRACT | Provided are therapeutic virus vectors, particularly, recombinant adeno-associated virus (rAAV) vectors, designed to contain an enhancer sequence that specifically restricts expression of an effector gene (e.g., an SCN1A-encoding polynucleotide, Gq-DREADD-encoding polynucleotide, or PSAM-encoding polynucleotide) contained in the vector to PV-expressing GABAergic interneuron or to neuron cell populations in the brain. The rAAV vectors, compositions and methods thereof are useful for treating subjects afflicted with neuropathologies, seizures, pharmacologically-intractable forms of epilepsy including Dravet syndrome (DS), a form of infantile epilepsy associated with severe seizures, cognitive impairment and premature death, as the cause of DS involves loss of function of a sodium channel encoded by the SCN1A gene. The described vectors restore expression of effector genes to the appropriate interneuron or neuron cell populations with specificity and sensitivity, advantageously to address the root cause of the disease by restoring the excitation-inhibition balance by means of gene-therapy (with SCN1A) or pharmacogenetics. |
| FILED | Monday, January 27, 2020 |
| APPL NO | 17/428538 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 48/0058 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195458 | Maguire et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Casey A. Maguire (Arlington, Massachusetts); Eloise Marie Hudry (Roxbury Crossing, Massachusetts); Killian S. Hanlon (Boston, Massachusetts) |
| ABSTRACT | Engineered AAV vectors for transgene expression, e.g., in the CNS, PNS, inner ear, heart, or retina, and methods of use thereof. Also provided are methods for discovering new engineered AAV vectors that mediate transgene expression in desired cell types. |
| FILED | Monday, March 30, 2020 |
| APPL NO | 17/442894 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 15/1037 (20130101) C12N 2750/14122 (20130101) C12N 2750/14143 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 40/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195461 | Engelhardt et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Iowa Research Foundation (Iowa City, Iowa); Spirovant Sciences, Inc. (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John F. Engelhardt (Iowa City, Iowa); Ziying Yan (Iowa City, Iowa); Yinghua Tang (Iowa City, Iowa); Eric Yuen (Los Altos, California); Shen Lin (Philadelphia, Pennsylvania) |
| ABSTRACT | The disclosure provides methods of expressing a transgene in a cell, methods of treating disorders in a subject in need thereof, and pharmaceutical compositions. In particular, the methods involve contacting a cell (e.g., a cell of a subject suffering from a disorder such as cystic fibrosis) with a recombinant adeno-associated virus (rAAV) that includes, in one embodiment, an AV.TL65 capsid protein and a polynucleotide that includes a transgene in combination with an augmenter of AAV transduction, thereby expressing the transgene in the cell. The disclosure also provides pharmaceutical compositions that include an rAAV that includes, in one embodiment, an AV.TL65 capsid protein and a polynucleotide including a transgene in combination with one or more augmenters. |
| FILED | Wednesday, April 15, 2020 |
| APPL NO | 17/603840 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/69 (20130101) A61K 31/704 (20130101) A61K 35/761 (20130101) A61K 38/05 (20130101) A61K 38/06 (20130101) A61K 38/07 (20130101) A61K 38/1709 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195474 | ROY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Utah Research Foundation (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anindita ROY (Salt lake City, Utah); Yuma MIYAI (Richmond, Virginia); Allesandro ROSSI (Salt Lake City, Utah); Ulmesh DESAI (Glen Allen, Virginia); Yukio SAIJOH (Salt Lake City, Utah); Kuberan BALAGURUNATHAN (Salt Lake City, Utah) |
| ABSTRACT | Methods for producing heparosan oligosaccharides and polysaccharides include culturing a recombinant host cell of a non-pathogenic E. coli strain, the host cell having been engineered to comprise the biosynthetic gene cluster kfiA, KfiB, kfiC, kfiD and, optionally, the gene elmA in culture conditions enabling direct expression heparosan oligosaccharides of specific sizes and/or of heparosan low molecular weight precursors by the host cell. The methods further includes obtaining such expression products during the culturing. A majority of the heparosan oligosaccharides range in size from approximately tetrasaccharide to approximately dodecasaccharide and a majority of the heparosan polysaccharides range in mass from approximately 5 KDa to approximately 30 KDa. |
| FILED | Friday, April 24, 2020 |
| APPL NO | 17/594643 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/205 (20210501) C12N 15/52 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/04 (20130101) Original (OR) Class C12P 19/18 (20130101) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/19 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195481 | SHIRIHAI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Califormia (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of Califormia (Oakland, California) |
| INVENTOR(S) | Orian S. SHIRIHAI (Los Angeles, California); Ilan Yaacov BENADOR-SHEN (Los Angeles, California); Rebeca ACIN-PEREZ (Los Angeles, California); Linsey STILES (Los Angeles, California) |
| ABSTRACT | Mitochondrial respirometry is used to study mitochondrial functionality in healthy tissues as well as mitochondrial diseases or diseases having a link to mitochondrial function such as diabetes mellitus type 2, obesity and cancer. However, barriers to studying energy metabolism are high due to the limitations of conventional technologies which require the analysis of living or freshly isolated biological specimens. The invention disclosed herein provides a new technology to assess cellular energy production capacity in previously frozen biological specimens. |
| FILED | Friday, May 15, 2020 |
| APPL NO | 17/610116 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/008 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195500 | UDDIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Imam UDDIN (Nashville, Tennessee); John S. PENN (Nashville, Tennessee); Craig L. DUVALL (Nashville, Tennessee) |
| ABSTRACT | The present disclosure relates to probes and methods for detecting nucleic acids, and for detecting and treating neovas-cularization. |
| FILED | Friday, April 24, 2020 |
| APPL NO | 17/606486 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/0032 (20130101) A61K 49/0052 (20130101) A61K 49/0054 (20130101) A61K 49/0082 (20130101) A61K 2039/55 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 43/00 (20180101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/02 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6818 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195503 | ZHANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Feng ZHANG (Cambridge, Massachusetts); Bernd ZETSCHE (Cambridge, Massachusetts); Johnathan S. GOOTENBERG (Cambridge, Massachusetts); Omar O. ABUDAYYEH (Cambridge, Massachusetts); Ian SLAYMAKER (Cambridge, Massachusetts) |
| ABSTRACT | The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA-targeting systems comprising a novel DNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA. Methods for making and using and uses of such systems, methods, and compositions and products from such methods and uses are also disclosed and claimed. |
| FILED | Friday, December 17, 2021 |
| APPL NO | 17/554333 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/113 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6816 (20130101) C12Q 1/6832 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195508 | Bao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaoyong Bao (Friendswood, Texas); Xiang Fang (Friendswood, Texas) |
| ABSTRACT | The present invention includes a method for treating Alzheimer's Disease, the method comprising the steps of: performing or having performed an assay that determines a level of one or more tRNA derived RNA fragments (tRFs), NOP2/Sun RNA methyltransferase 2 (NSun2), or angiogenin, in a biological sample when compared to a comparator sample; and if the patient has an increase in the one or more tRFs, a decrease in NOP2/Sun RNA NSun2 or NSun2 activity, or an increase in angiogenin or angiogenin activity then treating the patient with a NSun2 agonist, a nucleic acid or protein that inhibits or degrades tRFs, or an inhibitor of angiogenin. |
| FILED | Friday, December 17, 2021 |
| APPL NO | 17/554782 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6851 (20130101) Original (OR) Class C12Q 1/6883 (20130101) C12Q 2600/112 (20130101) C12Q 2600/156 (20130101) C12Q 2600/178 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195514 | Blainey et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul Blainey (Cambridge, Massachusetts); Jacob Borrajo (Cambridge, Massachusetts); Mohamad Najia (Cambridge, Massachusetts); Hong Anh Anna Le (Cambridge, Massachusetts) |
| ABSTRACT | The present invention provides for methods to obtain transcriptome-wide multiple information-rich samples from living cells while minimally disrupting the cell. The subject matter disclosed herein is generally related to nucleic acid constructs for continuous monitoring of live cells. Specifically, the subject matter disclosed herein is directed to nucleic acid constructs that encode a fusion protein and a construct RNA sequence that induce live cells to self-report cellular contents while maintaining cell viability. The present invention may be used to monitor gene expression in single cells while maintaining cell viability. |
| FILED | Sunday, March 29, 2020 |
| APPL NO | 17/599722 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) C07K 14/395 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/62 (20130101) C12N 15/86 (20130101) C12N 2740/15022 (20130101) C12N 2740/15043 (20130101) C12N 2830/002 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6869 (20130101) Original (OR) Class C12Q 1/6876 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5023 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195523 | SALK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jesse SALK (Seattle, Washington); Lawrence A. LOEB (Bellevue, Washington); Michael SCHMITT (Seattle, Washington) |
| ABSTRACT | Next Generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate hundreds of billions of nucleotides of DNA sequence in a single experiment, the error rate of approximately 1% results in hundreds of millions of sequencing mistakes. These scattered errors can be tolerated in some applications but become extremely problematic when “deep sequencing” genetically heterogeneous mixtures, such as tumors or mixed microbial populations. To overcome limitations in sequencing accuracy, a method Duplex Consensus Sequencing (DCS) is provided. This approach greatly reduces errors by independently tagging and sequencing each of the two strands of a DNA duplex. As the two strands are complementary, true mutations are found at the same position in both strands. In contrast, PCR or sequencing errors will result in errors in only one strand. This method uniquely capitalizes on the redundant information stored in double-stranded DNA, thus overcoming technical limitations of prior methods utilizing data from only one of the two strands. |
| FILED | Monday, December 13, 2021 |
| APPL NO | 17/644059 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6869 (20130101) C12Q 1/6876 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195526 | RABINOWITZ et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Natera, Inc. (San Carlos, California) |
| ASSIGNEE(S) | Natera, Inc. (San Carlos, California) |
| INVENTOR(S) | Matthew RABINOWITZ (San Francisco, California); Milena BANJEVIC (Los Altos Hills, California); Zachary DEMKO (San Francisco, California); David JOHNSON (San Francisco, California); Dusan KIJACIC (Los Altos Hills, California); Dimitri PETROV (Stanford, California); Joshua SWEETKIND-SINGER (San Jose, California); Jing XU (Jersey City, New Jersey) |
| ABSTRACT | Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available. Poorly or incorrectly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related individuals. In accordance with one embodiment, incomplete genetic data from an embryonic cell are reconstructed at a plurality of loci using the more complete genetic data from a larger sample of diploid cells from one or both parents, with or without haploid genetic data from one or both parents. In another embodiment, the chromosome copy number can be determined from the measured genetic data, with or without genetic information from one or both parents. |
| FILED | Thursday, March 03, 2022 |
| APPL NO | 17/685785 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6827 (20130101) C12Q 1/6869 (20130101) C12Q 1/6876 (20130101) C12Q 1/6883 (20130101) Original (OR) Class C12Q 2537/149 (20130101) C12Q 2545/114 (20130101) C12Q 2600/118 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) G16B 25/00 (20190201) G16B 30/00 (20190201) G16B 40/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195535 | Meltzer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen J. Meltzer (Lutherville, Maryland); Ke Ma (Hanover, Maryland); Yulan Cheng (Ellicott City, Maryland); John Martin Abraham (Woodbine, Maryland) |
| ABSTRACT | The present invention relates to the field of cancer. More specifically, the present invention provides compositions and methods useful for detecting and treating esophageal cancer. In a specific embodiment, a method for identifying a subject having esophageal squamous cell carcinoma (ESCC) comprises (a) extracting genomic DNA from a sample obtained from the subject; (b) performing a conversion reaction on the genomic DNA in vitro to convert unmethylated cytosine to uracil by deamination; and (c) detecting nucleic acid methylation of one or more genes in the converted genomic DNA, wherein detecting nucleic acid methylation e identifies the subject as having ESCC. The one or more genes can comprise ZNF542, ZNF132, cg20655070, TAC1 and SLC35F1. In a more specific embodiment, the one or more genes comprise ZNF542 and ZNF132 and can further comprise detecting the nucleic acid N methylation of one or more of cg20655070, TAC1 and SLC35F1. |
| FILED | Thursday, April 16, 2020 |
| APPL NO | 17/604255 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/154 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220196532 | Cahalan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ension, Inc. (Butler, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Linda Cahalan (Fort Myers, Florida); Patrick Cahalan (Fort Myers, Florida); Michael Hegy (FORT MYERS, Florida) |
| ABSTRACT | A flow-based biological testing platform comprises a stationary base; a reciprocating base mounted on the stationary base, configured for reciprocating motion on the base; and at least one flexible tubular test loop coupled to both the stationary and the reciprocating base, wherein each test loop is configured to be selectively filled with a biologic fluid, and wherein each test loop includes at least one check valve mounted within the test loop allowing flow in a single flow direction within the test loop, and a fluid loading and removal system attached to the stationary base allowing fluid to be supplied to and withdrawn from the flexible tubular test loop; wherein reciprocation of the reciprocating base induces fluid flow in a single direction within each flexible test loop. |
| FILED | Monday, October 18, 2021 |
| APPL NO | 17/451315 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502 (20130101) B01L 3/508 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 11/04 (20130101) Original (OR) Class G01N 33/86 (20130101) G01N 2035/00524 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220196635 | Robinson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen Robinson (Atlanta, Georgia); Jonathan Chang (Atlanta, Georgia); Shuichi Takayama (Atlanta, Georgia) |
| ABSTRACT | An exemplary embodiment of the present disclosure provides A method and system for forming a microscale cell-laden matrix using an aqueous two-phase system (“ATPS”) comprising a mixture of a first material and a second material having a phase boundary between the first and second materials. The method can comprise mixing an enzyme with the first material, mixing a protein with the second material, and mixing a suspension comprising cells with one of the first material or the second material, wherein the enzyme, protein, and suspension comprising cells generate the cell-laden matrix and wherein the first material comprises a first polymer comprising polyethylene glycol and the second material can be a second polymer selected from the group consisting of dextran, polyvinyl pyrrolidone, polyvinyl alcohol, or ficoll. |
| FILED | Friday, October 29, 2021 |
| APPL NO | 17/514264 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 21/18 (20130101) C12M 23/16 (20130101) C12M 23/22 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0656 (20130101) C12N 9/6429 (20130101) C12N 2533/54 (20130101) C12N 2533/56 (20130101) Enzymes C12Y 304/21005 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/30 (20130101) G01N 33/5044 (20130101) Original (OR) Class G01N 2800/52 (20130101) G01N 2800/7052 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220196636 | Blazeski et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adriana Blazeski (Baltimore, Maryland); Leslie Tung (Baltimore, Maryland) |
| ABSTRACT | Described herein are methods for evaluating a cardiac preparation. The methods involve providing at least one sample comprising one or more cardiac cells, pacing the one or more cardiac cells at two or more fixed rates; and measuring a fixed response of the one or more cardiac cells at each of the two or more fixed rates. Also described herein are methods for evaluating the cardiac effect of a compound. The methods involve providing at least one sample comprising one or more cardiac cells; contacting each sample with the compound; pacing the one or more cardiac cells at two or more fixed rates; and measuring a fixed response of the one or more cardiac cells to the compound at each of the two or more fixed rates. |
| FILED | Monday, March 30, 2020 |
| APPL NO | 17/599325 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0657 (20130101) C12N 2503/02 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5041 (20130101) G01N 33/5061 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220196638 | Chamberlin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Meso Scale Technologies, LLC. (Rockville, Maryland) |
| ASSIGNEE(S) | Meso Scale Technologies, LLC. (Rockville, Maryland) |
| INVENTOR(S) | Ian Chamberlin (Burtonsville, Maryland); Charles M. Clinton (Clarksburg, Maryland); Eli N. Glezer (Chevy Chase, Maryland); Bandele Jeffrey-Coker (Darnestown, Maryland); Manish Kochar (Rockville, Maryland); Sandor Kovacs (Middletown, Delaware); DT Le (Beltsville, Maryland); Aaron Leimkuehler (Upper St. Clair, Pennsylvania); Greg Pinckney (Myersville, Maryland); Kristian Roth (Germantown, Maryland); George Sigal (Rockville, Maryland); Fei Yin (North Potomac, Maryland) |
| ABSTRACT | We describe apparatuses, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of liquid samples in a clinical point of care setting. |
| FILED | Tuesday, December 28, 2021 |
| APPL NO | 17/563249 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5085 (20130101) B01L 2200/16 (20130101) B01L 2300/105 (20130101) B01L 2300/0829 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/66 (20130101) G01N 21/6452 (20130101) G01N 33/5304 (20130101) Original (OR) Class G01N 33/54326 (20130101) G01N 33/54366 (20130101) G01N 33/56983 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220196642 | Muthusamy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California); Howard Hughes Medical Institute (Chevy Chase, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anand K. Muthusamy (Pasadena, California); Henry A. Lester (Pasadena, California); Loren Looger (Ashburn, Virginia); Jonathan S. Marvin (Ashburn, Virginia) |
| ABSTRACT | Disclosed herein include engineered opioid biosensors, and related compositions, vectors, cells, and systems. Also disclosed include methods that provide opioid biosensors with sensitivity and selectivity suitable for continuous opioid monitoring as well as the use of the opioid biosensors for detecting one or more specific opioids. The opioid biosensors, which are capable of undergoing a detectable conformational change upon binding to an opioid, can each comprise a first periplasmic binding protein (PBP) domain and a second PBP domain connected to the first PBP domain, wherein at least one of the first PBP domain and the second PBP domain comprises one or more mutations. |
| FILED | Thursday, December 16, 2021 |
| APPL NO | 17/553725 |
| CURRENT CPC | Peptides C07K 14/43595 (20130101) C07K 2319/20 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/542 (20130101) Original (OR) Class G01N 33/9486 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220196646 | Lindsay et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stuart Lindsay (Scottsdale, Arizona); Eathen Ryan (Scottsdale, Arizona) |
| ABSTRACT | The present disclosure provides devices, systems, and methods related to protein bioelectronics. In particular, the present disclosure provides devices, systems, and methods for forming electrical contacts to a protein with high yield, which facilitates the manufacture of analytical devices to detect and measure the electrical characteristics corresponding to protein function. |
| FILED | Thursday, December 16, 2021 |
| APPL NO | 17/553392 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/04 (20130101) G01N 33/5438 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220196652 | Lennon et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| INVENTOR(S) | Vanda A. Lennon (Rochester, Minnesota); Sean J. Pittock (Rochester, Minnesota); Shannon Hinson (Rochester, Minnesota) |
| ABSTRACT | The invention provides prognostic methods for evaluating the severity of NMO and NMO-associated diseases as well as methods of treating NMO and NMO-associated diseases. |
| FILED | Wednesday, December 29, 2021 |
| APPL NO | 17/565098 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/439 (20130101) A61K 39/395 (20130101) A61K 45/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/564 (20130101) Original (OR) Class G01N 2333/705 (20130101) G01N 2800/52 (20130101) G01N 2800/285 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220196658 | Rathe et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington); Seattle Children's Hospital d/b/a Seattle Children's Research Institute (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jennifer Rathe (Seattle, Washington); Michael J. Gale, JR. (Seatle, Washington) |
| ABSTRACT | The disclosure provides method, kits, and devices for detecting and/or assessing neutralizing antibodies in a sample, e.g. a biological sample. The detection comprises contacting the sample to an antigen of a virus of interest, and detecting the binding of the one or more IgG3 antibodies to the antigen. The presence of IgG3 antibodies that specifically bind the virus antigen indicates neutralizing antibodies against the virus. The detection protocol can be implemented in a variety of configurations and formats, including ELISA-type and lateral flow formats. The method can be used to assess, e.g., a subject's relative immunity or infection status regarding a particular virus, such as SARS-CoV-2. |
| FILED | Tuesday, December 21, 2021 |
| APPL NO | 17/558244 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/566 (20130101) G01N 33/5091 (20130101) G01N 33/56983 (20130101) Original (OR) Class G01N 2333/165 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220196661 | Gundry |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rebekah L. Gundry (Milwaukee, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rebekah L. Gundry (Milwaukee, Wisconsin) |
| ABSTRACT | The present invention is directed to particular monoclonal antibodies and fragments thereof that find use in the detection and isolation of in vitro differentiated cardiomyocytes. In particular, the present invention relates to LSMEM2 biomarkers, including monoclonal antibodies having specificity for cell surface protein LSMEM2 and to methods of using such biomarkers for diagnosis of cardiovascular injury. |
| FILED | Friday, December 18, 2020 |
| APPL NO | 17/127237 |
| CURRENT CPC | Peptides C07K 16/28 (20130101) C07K 2317/34 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/577 (20130101) Original (OR) Class G01N 33/56966 (20130101) G01N 2800/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220196663 | EGLAND et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SANFORD HEALTH (Sioux Falls, South Dakota); INANOVATE, INC. (Sioux Falls, South Dakota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kristi EGLAND (Sioux Falls, South Dakota); Rick EVANS (Sioux Falls, South Dakota); Eagappanath THIRUPPATHI (Sioux Falls, South Dakota); David URE (Sioux Falls, South Dakota); Matt KOSTURA (Sioux Falls, South Dakota); Etienne Z. GNIMPIEBA (Sioux Falls, South Dakota) |
| ABSTRACT | Methods and related reagents are disclosed for diagnosing cancer, prognosing cancer occurrence or recurrence, and/or monitoring cancer therapy, involving contacting a bodily fluid sample from a subject at risk of having cancer or cancer recurrence, or from a subject that has been treated for cancer wl fit (a) one or more first antibody detection marker molecules that hind to human autoantibodies against at least one tumor associated antigen (TAA); and (fa) one or more second antibody detection marker molecules that bind to human autoantibodies against at least one extractable nuclear antigen (ENA). |
| FILED | Tuesday, June 09, 2020 |
| APPL NO | 17/611351 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57415 (20130101) Original (OR) Class G01N 2333/8125 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220196668 | Barbero et al. |
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| FUNDED BY |
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| APPLICANT(S) | Meso Scale Technologies, LLC. (Rockville, Maryland) |
| ASSIGNEE(S) | Meso Scale Technologies, LLC. (Rockville, Maryland) |
| INVENTOR(S) | Simone Barbero (Germantown, Maryland); Eli N. Glezer (Del Mar, California); Anu Mathew (North Potomac, Maryland); Mingyue Wang (Potomac, Maryland) |
| ABSTRACT | The present invention relates to methods of diagnosing a kidney disorder in a patient, as well as methods of monitoring the progression of a kidney disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein. |
| FILED | Monday, March 14, 2022 |
| APPL NO | 17/693918 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/44 (20130101) A61K 31/404 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/485 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5743 (20130101) G01N 33/57438 (20130101) Original (OR) Class G01N 2800/60 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220196685 | Chang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher J. Chang (Berkeley, California); Yik Sham Clive Chung (Berkeley, California); Sumin Lee (Berkeley, California) |
| ABSTRACT | The present disclosure provides Forster resonance energy transfer (FRET)-based probes for detecting copper, e.g., for detecting Cu(I) in live cells. The present disclosure provides methods for detecting copper, e.g., for detecting Cu(I) in live cells, using a FRET-based probe of the present disclosure. |
| FILED | Wednesday, April 29, 2020 |
| APPL NO | 17/603205 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/84 (20130101) Original (OR) Class G01N 33/542 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220196697 | SCHIAVINATO EBERLIN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas); BAYLOR COLLEGE OF MEDICINE (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Livia SCHIAVINATO EBERLIN (Austin, Texas); Thomas MILNER (Austin, Texas); Jialing ZHANG (Austin, Texas); Noah GIESE (Austin, Texas); John LIN (Austin, Texas); Jeffrey R. KUHN (Austin, Texas); James SULIBURK (Houston, Texas); Nitesh KATTA (Austin, Texas) |
| ABSTRACT | Methods and apparatus are provided for cleaning or exchanging medical devices. Certain embodiments may include a cassette comprising a plurality of medical devices, where the orientation of the cassette can be changed while the cassette is coupled to a processing instrument. |
| FILED | Friday, July 23, 2021 |
| APPL NO | 17/383981 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 10/04 (20130101) A61B 10/0045 (20130101) A61B 10/0283 (20130101) A61B 2010/045 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 35/1095 (20130101) Original (OR) Class Electric Discharge Tubes or Discharge Lamps H01J 49/0413 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220197018 | Sabesan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington); The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ramkumar Sabesan (Seattle, Washington); Vimal Prabhu Pandiyan (Seattle, Washington); Daniel Palanker (Seattle, Washington) |
| ABSTRACT | An optical instrument includes a first light source configured to generate a broadband light; an optical module configured to collimate the broadband light and focus the broadband light into a line; a beam splitter configured to split the broadband light into a sample beam and a reference beam and configured to combine the reference beam with the sample beam to form an interference beam; a control system configured to scan the sample beam on a retina of a subject along an axis that is substantially perpendicular to the sample beam; a second light source configured to stimulate the retina with a visible light to induce a physical change within the retina such that the sample beam is altered by the physical change; an image sensor; and a dispersive element configured to receive the interference beam from the beam splitter and to disperse the interference beam onto the image sensor. |
| FILED | Saturday, April 25, 2020 |
| APPL NO | 17/605182 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/102 (20130101) A61B 5/0066 (20130101) Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/02044 (20130101) G01B 9/02091 (20130101) Optical Elements, Systems, or Apparatus G02B 21/0012 (20130101) G02B 26/101 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220198245 | Cleland et al. |
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| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas A. Cleland (Freeville, New York); Nabil Imam (San Francisco, California); Ayon Borthakur (Ithaca, New York) |
| ABSTRACT | A computer-implemented method of training a neural network to recognize sensory patterns includes obtaining input data, preprocessing the input data in one or more preprocessors of the neural network, and applying the preprocessed input data to a core portion of the neural network. The core portion of the neural network includes a plurality of principal neurons and a plurality of interneurons, and is configured to implement a feedback loop from the interneurons to the principal neurons that supports persistent unsupervised differentiation of multiple learned sensory patterns over time. The method further includes obtaining an output from the core portion, and performing at least one automated action based at least in part on the output obtained from the core portion. The neural network may be adaptively expanded to facilitate the persistent unsupervised differentiation of multiple learned sensory patterns over time by incorporating additional interneurons into at least the core portion. |
| FILED | Friday, April 10, 2020 |
| APPL NO | 17/603171 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/049 (20130101) Original (OR) Class G06N 3/063 (20130101) G06N 3/0445 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220198629 | Rahimi Nasrabadi et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for the State University of New York (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hamed Rahimi Nasrabadi (Brooklyn, New York); José-Manuel Alonso (New York, New York) |
| ABSTRACT | Images may be altered based on ON-OFF visual pathway information processing. A process for generating altered images may include separating an original image into distinct images based on luminance values for each pixel of the pixels that form the original image. The distinct images may include a first and a second separated image, where each separated image includes distinct pixels. Additionally, the process may include determining a first luminance range for the first separated image based on the luminance value for each pixel forming the first separated image, and determining a second luminance range for the second separated image based on the luminance value for each pixel forming the second separated image. The process may also include adjusting visual parameters of the first and second separated images, and combining the adjusted, first and second separated images to generate the altered image. |
| FILED | Monday, December 20, 2021 |
| APPL NO | 17/556921 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 5/50 (20130101) Original (OR) Class G06T 7/90 (20170101) G06T 2207/10081 (20130101) G06T 2207/10088 (20130101) G06T 2207/10116 (20130101) G06T 2207/10132 (20130101) G06T 2207/20212 (20130101) Image or Video Recognition or Understanding G06V 10/56 (20220101) G06V 10/60 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220198662 | Ay et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hakan Ay (Boston, Massachusetts); Jayashree Kalpahy-Cramer (Boston, Massachusetts) |
| ABSTRACT | An image analysis system including at least one processor and at least one memory is provided. The image analysis system is configured to receive image data associated with a brain of a patient, the image data including a first three-dimensional (3D) diffusion weighted imaging (DWI) image acquired using a magnetic resonance imaging (MRI) system and a second 3D DWI image, concurrently provide the first 3D DWI image to a first channel of a trained model and the second 3D DWI image to a second channel of the trained model, receive an indicator associated with the first 3D DWI image and the second 3D DWI image from the model, generate a report based on the indicator, and cause the report to be output to at least one of a memory or a display. |
| FILED | Wednesday, May 13, 2020 |
| APPL NO | 17/611394 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0042 (20130101) A61B 5/055 (20130101) A61B 5/742 (20130101) A61B 5/7267 (20130101) A61B 5/7275 (20130101) A61B 2576/026 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/5608 (20130101) G01R 33/56341 (20130101) Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 2200/04 (20130101) G06T 2207/10092 (20130101) G06T 2207/20076 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30016 (20130101) G06T 2207/30096 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220201274 | ACHILEFU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Samuel ACHILEFU (St. Louis, Missouri); Yang LIU (Akron, Ohio); Viktor GRUEV (St. Louis, Missouri); Joseph P. CULVER (Webster Groves, Missouri); Walter AKERS (Columbia, Illinois); Adam BAUER (Webster Groves, Missouri) |
| ABSTRACT | A goggle system is provided. The goggle system includes a computing device, a goggle device configured to be worn by a user and including a detector configured to simultaneously acquire image data of a subject in a first image mode and a second image mode, at least one eye assembly configured to display at least one of an image in the first image mode, an image in the second image mode, and a hybrid image including pixels of image data from the first image mode and pixels of image data from the second image mode, and a communications module configured to transmit acquired image data from the goggle device to the computing device. |
| FILED | Tuesday, March 08, 2022 |
| APPL NO | 17/689339 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/0005 (20130101) A61B 34/25 (20160201) A61B 90/30 (20160201) A61B 90/36 (20160201) A61B 90/361 (20160201) A61B 2090/364 (20160201) Preparations for Medical, Dental, or Toilet Purposes A61K 49/0032 (20130101) A61K 49/0034 (20130101) A61K 49/0056 (20130101) Peptides C07K 7/06 (20130101) Optical Elements, Systems, or Apparatus G02B 27/017 (20130101) Pictorial Communication, e.g Television H04N 5/374 (20130101) H04N 13/344 (20180501) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20220192636 | Hatlan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sonivate Medical, Inc. (Portland, Oregon) |
| ASSIGNEE(S) | Sonivate Medical, Inc. (Portland, Oregon) |
| INVENTOR(S) | James T. Hatlan (Portland, Oregon); Austen Angell (Portland, Oregon); William McDonough (Portland, Oregon) |
| ABSTRACT | Disclosed are wearable ultrasound probes for use in trauma triage and assessment. The probes define a finger-receiving aperture and include an ultrasound array disposed adjacent the distal end wherein the ultrasound array is angled toward the bottom side of the probe about 10-50 degrees from the longitudinal axis and a second ultrasound array adjacent the distal end and proximal to the first ultrasound array, wherein the second ultrasound array is angled about 105-155 degrees from the first ultrasound array. |
| FILED | Thursday, December 17, 2020 |
| APPL NO | 17/125662 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/4427 (20130101) A61B 8/4455 (20130101) Original (OR) Class A61B 8/4477 (20130101) A61B 8/4488 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220192846 | Mooney et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Dephy, Inc. (Maynard, Massachusetts) |
| ASSIGNEE(S) | Dephy, Inc. (Maynard, Massachusetts) |
| INVENTOR(S) | Luke Mooney (Sudbury, Massachusetts); Jean-Francois Duval (Belmont, Massachusetts) |
| ABSTRACT | The present invention is directed to an autonomous exoskeleton device that includes one or more actuators, one or more controllers, one or more sensors with one or more unidirectional transmissions. The present invention provides a mechanical joint in parallel with a biological joint. The exoskeleton device preferably includes and electric motor and winch, chain, belt, cam transmission or other mechanism for providing unidirectional force to assist rotation about the biologic joint. Moreover, a controller, a motor angle sensor, joint angle sensor and/or force sensor may be used for additional control and monitoring of the device. The motor may be any type of motor, but is preferably brushless in configuration where its diameter is larger than its length to provide a compact and lightweight exoskeleton device. |
| FILED | Wednesday, March 09, 2022 |
| APPL NO | 17/690547 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4528 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/70 (20130101) A61F 2/6607 (20130101) Original (OR) Class A61F 5/01 (20130101) Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 1/024 (20130101) A61H 1/0262 (20130101) A61H 1/0266 (20130101) A61H 3/00 (20130101) A61H 2003/007 (20130101) A61H 2201/14 (20130101) A61H 2201/50 (20130101) A61H 2201/0134 (20130101) A61H 2201/0192 (20130101) A61H 2201/1215 (20130101) A61H 2201/1418 (20130101) A61H 2201/1642 (20130101) A61H 2201/1671 (20130101) A61H 2201/1676 (20130101) A61H 2201/5061 (20130101) A61H 2201/5069 (20130101) A61H 2201/5097 (20130101) A61H 2205/10 (20130101) A61H 2205/102 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193302 | FRANCIS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Embody, Inc. (Norfolk, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael P. FRANCIS (Norfolk, Virginia); Kyle CHRISTENSEN (Norfolk, Virginia); Nicholas THAYER (Norfolk, Virginia) |
| ABSTRACT | A biocompatible scaffold construct may include a biocompatible hydrogel and at least one biomaterial microfiber strand wound to form a plurality of microfiber segments in proximity to one another and arranged in an organized configuration. |
| FILED | Tuesday, November 30, 2021 |
| APPL NO | 17/538296 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/24 (20130101) Original (OR) Class A61L 27/367 (20130101) A61L 2430/30 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 70/00 (20141201) B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193303 | FRANCIS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Embody, Inc. (Norfolk, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael P. FRANCIS (Norfolk, Virginia); Kyle CHRISTENSEN (Norfolk, Virginia) |
| ABSTRACT | A biocompatible scaffold construct includes a plurality of collagen fiber strands, a first portion of which have been coated by a first biocompatible solution and, optionally, a second portion of which have been coated by a second biocompatible solution different than the first biocompatible solution. The coatings may include cells. And the scaffold is constructed on rotating frame collectors. |
| FILED | Tuesday, November 30, 2021 |
| APPL NO | 17/538762 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/24 (20130101) Original (OR) Class A61L 27/367 (20130101) A61L 2430/30 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193309 | Anderson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard Rox Anderson (Boston, Massachusetts); Joshua Tam (Boston, Massachusetts); Christiane Fuchs (Boston, Massachusetts) |
| ABSTRACT | Systems and methods for assembling a plurality of tissue grafts are provided. A method includes applying a magnetic coating over a surface of a donor site and harvesting the plurality of micro tissue grafts from the donor site, so that an upper surface of each of the plurality of micro tissue grafts contains the coating. The method also includes arranging a magnet over the magnetic coating to induce the plurality of micro tissue grafts to organize in a desired orientation, forming a tissue construct containing the plurality of micro tissue grafts arranged in the desired orientation, and applying the tissue construct to a recipient site. |
| FILED | Thursday, April 30, 2020 |
| APPL NO | 17/606956 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/322 (20130101) A61B 2017/00876 (20130101) A61B 2017/3225 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/34 (20130101) A61L 27/60 (20130101) A61L 27/362 (20130101) A61L 27/446 (20130101) Original (OR) Class Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 35/00 (20130101) A61M 2202/09 (20130101) A61M 2205/0288 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193329 | Pedroni et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lynntech, Inc. (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jesse Pedroni (Castle Rock, Colorado); Jibi Varughese (Eindhoven, Netherlands); Grayson Ridge (Highlands Ranch, Colorado); Graham Weeks (College Station, Texas); Alex Moreland (College Station, Texas); Jonathan Presley (College Station, Texas); Jonathan A. Reeh (College Station, Texas); Tiffany Jefferson (The Woodlands, Texas); Seth Berry (Bryan, Texas); Seth Cocking (Sugar Land, Texas); Justin McIntire (College Station, Texas); Jady Stevens (Bryan, Texas); Chris Hadley (Bryan, Texas); John Zbranek (College Station, Texas); Rebecca Berger (Bryan, Texas); Kacey G. Ortiz (College Station, Texas); Geoffrey Duncan Hitchens (Allen, Texas); Ashwin Balasubramanian (The Woodlands, Texas) |
| ABSTRACT | A pump including a disposable component including a disposable component inlet port coupled to a first disposable conduit in fluid communication with a fluid medium source, wherein the first disposable conduit includes a disposable piston pump assembly and a disposable bubble eliminator, and the first disposable conduit is in fluid communication with a disposable component outlet port, wherein the disposable bubble eliminator is in fluid communication with a lumen of the first disposable conduit and is operable to reduce a gas content of a fluid medium; wherein the disposable piston pump assembly is operable to pump the fluid medium from the disposable component inlet port, through the first disposable conduit and the disposable bubble eliminator, to the disposable component outlet port; and a reusable component including a reusable movable stage operable to compress the disposable piston pump assembly; and a reusable mechanical actuator operable to drive the movable stage. |
| FILED | Thursday, September 03, 2020 |
| APPL NO | 17/011749 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/1454 (20130101) Original (OR) Class A61M 2005/5046 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193411 | Oliver et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Connecticut (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Douglas L. Oliver (West Hartford, Connecticut); Alice L. Burghard (Wolcott, Connecticut); Christopher Lee (West Hartford, Connecticut); Emily Fabrizio-Stover (Rocky Hill, Connecticut) |
| ABSTRACT | Disclosed is a method. The method may include receiving first data based on a stimulus defined according to a patient. The method may include receiving second data based on the stimulus. The method may include determining an indication of tinnitus. The indication of tinnitus may be based on a comparison between the first data and the second data. The method may include administering a tinnitus treatment on the patient. The treatment may be based on the indication. A tinnitus treatment may include one or more of an biological feedback with the patient, transcranial magnetic stimulation of the patient, surgical insertion of the cochlear implant, the cognitive behavioral therapy, the transcutaneous electrical stimulation, pharmacologic therapy on the patient, or applying a hearing aid to the patient. |
| FILED | Friday, December 17, 2021 |
| APPL NO | 17/554973 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/123 (20130101) A61B 5/128 (20130101) A61B 5/4836 (20130101) A61B 5/7228 (20130101) A61B 5/7235 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0456 (20130101) A61N 1/36036 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193774 | Mirzendehdel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Palo Alto Research Center Incorporated (Palo Alto, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amirmassoud Mirzendehdel (San Mateo, California); Morad Behandish (Mountain View, California); Saigopal Nelaturi (Mountain View, California) |
| ABSTRACT | A geometry model is defined of a part targeted for a manufacturing operation that includes an additive process followed by a subtractive process. Potential build orientations of the geometry model used in the additive processes are defined, as are one or more removal tools of the subtractive process. For each of the potential build orientations, supports that are used by the additive process at the orientation are determined. One of the build orientations is selected that minimizes portions of one of the supports that are inaccessible via at least one of the removal tools. |
| FILED | Monday, December 21, 2020 |
| APPL NO | 17/129765 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/28 (20210101) B22F 10/40 (20210101) Original (OR) Class B22F 10/85 (20210101) B22F 10/385 (20210101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193988 | Walker et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David A. Walker (Evanston, Illinois); James L. Hedrick, III (Evanston, Illinois); Chad A. Mirkin (Wilmette, Illinois) |
| ABSTRACT | Methods and apparatus comprising a dewetting material and a polymerization liquid that are immiscible and dewetting, and can be used for the formation of three-dimensional objects, wherein the method does not require a dead zone. Additionally, methods and apparatus that employ the use of a flowing dewetting material to provide a shearing interface to reduce interfacial adhesive forces. |
| FILED | Monday, March 09, 2020 |
| APPL NO | 17/436754 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/129 (20170801) Original (OR) Class B29C 64/307 (20170801) B29C 64/357 (20170801) B29C 64/364 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 40/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220194498 | Hart et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Army (Washington, District of Columbia) |
| ASSIGNEE(S) | Government of the United States, as represented by the Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | Robert James Hart (Bruce Township, Michigan); Andrew Quintin Smail (Shelby Township, Michigan) |
| ABSTRACT | A band track including a band having an inner surface, an outer surface, a first side face, and a second side face; a plurality of teeth extending from the inner surface and spaced apart circumferentially around the inner surface; a plurality of lugs extending from the outer surface and each spaced a distance apart circumferentially around the outer surface; a plurality of living hinges defined within the band circumferentially between each of the plurality of teeth; and at least one fiber-reinforcement disposed circumferentially within a neutral plane of the plurality of living hinges and a method of making the same. |
| FILED | Tuesday, December 22, 2020 |
| APPL NO | 17/130416 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 50/02 (20141201) Motor Vehicles; Trailers B62D 55/28 (20130101) B62D 55/244 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220194524 | Chua et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Palo Alto Research Center Incorporated (Palo Alto, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher L. Chua (San Jose, California); Norine E. Chang (Menlo Park, California); Julie Ann Bert (Palo Alto, California); Scott J. Limb (Palo Alto, California); Steven Neltner (San Carlos, California); Eric Cocker (Redwood City, California) |
| ABSTRACT | An apparatus includes a structure comprising a predetermined breakable region and a mechanical actuator disposed at or proximate the predetermined breakable region. The mechanical actuator comprises an impact member coupled to a spring arrangement, and a restraint member operably coupled to the spring arrangement. A trigger source is operably coupled to an electrical power source. The trigger source, in response to receiving current from the electrical power source, is configured to release or break the restraint member so as to allow the spring arrangement to forcibly move the impact member into contact with, and break, the predetermined breakable region. |
| FILED | Monday, December 21, 2020 |
| APPL NO | 17/128714 |
| CURRENT CPC | Ships or Other Waterborne Vessels; Equipment for Shipping B63B 22/26 (20130101) Original (OR) Class B63B 59/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195017 | Ingber et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Donald E. Ingber (Boston, Massachusetts); Michael Super (Lexington, Massachusetts); Alexander L. Watters (North Andover, Massachusetts) |
| ABSTRACT | Described herein are engineered microbe-targeting or microbe-binding molecules, kits comprising the same and uses thereof. The microbe-targeting or microbe-binding molecules can comprise a microbe surface-binding domain linked to a portion of an Fc region. Further, the microbe-targeting molecules can be conjugated to substrate (e.g., a magnetic particle) to form a microbe-targeting substrate. Such microbe-targeting molecules and/or substrates and the kits comprising the same can be used in various applications, such as diagnosis and/or treatment of an infection caused by microbes. Moreover, the microbe-targeting molecules and/or substrates can be easily regenerated after use. |
| FILED | Thursday, December 30, 2021 |
| APPL NO | 17/565783 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 14/7056 (20130101) C07K 16/12 (20130101) Original (OR) Class C07K 16/14 (20130101) C07K 16/1203 (20130101) C07K 16/1271 (20130101) C07K 2317/41 (20130101) C07K 2317/52 (20130101) C07K 2317/71 (20130101) C07K 2317/73 (20130101) C07K 2319/30 (20130101) C07K 2319/33 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/48735 (20130101) G01N 33/54326 (20130101) G01N 33/56911 (20130101) G01N 33/56961 (20130101) G01N 2333/31 (20130101) G01N 2333/40 (20130101) G01N 2333/245 (20130101) G01N 2400/00 (20130101) G01N 2800/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195078 | WAGENER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenneth B. WAGENER (Gainesville, Florida); Julia Grace PRIBYL (Gainesville, Florida); Michael H. BELL (North East, Maryland) |
| ABSTRACT | A method of carrying out a metathesis reaction includes the combination of at least one alkene or non conjugated diene with a Ruthenium-based catalyst with an cyclic(alkyl)(amino)carbene ligand to form a reaction mixture, heating the reaction mixture to a temperature of 100° C. or greater in the absence of a solvent in bulk conditions, and mechanically stirring the reaction mixture. The reaction can be an ADMET, ROMP, a metathesis ring-closure or an olefin exchange reaction. |
| FILED | Monday, March 30, 2020 |
| APPL NO | 17/598975 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 15/0046 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 4/80 (20130101) Original (OR) Class C08F 36/14 (20130101) C08F 36/045 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195360 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yu Shrike Zhang (Cambridge, Massachusetts); Ali Khademhosseini (Los Angeles, California) |
| ABSTRACT | Methods fabricate an endothelialized myocardium usable for screening of a drug. A microfibrous hydrogel scaffold is manufactured with additive manufacturing that concurrently bioprints endothelial cells directly within the microfibrous hydrogel scaffold. A bioink is bioprinted into an arrangement of one or more microfibers. The bioink includes at least one crosslinking component and suspended endothelial cells. The crosslinking component or components are crosslinked to yield the microfibrous hydrogel scaffold having the endothelial cells embedded directly within. The microfibrous hydrogel scaffold is seeded with cardiomyocytes to yield the endothelialized myocardium with a controlled anisotropy. The endothelialized myocardium can be incubated until the endothelialized myocardium matures into spontaneously beating myocardial tissue having contractions aligned with the controlled anisotropy. The beating myocardial tissue can be used to screen a drug when the beating myocardial tissue is embedded within a microfluidic perfusion bioreactor. |
| FILED | Monday, March 14, 2022 |
| APPL NO | 17/694432 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) Original (OR) Class C12M 23/16 (20130101) C12M 25/14 (20130101) C12M 35/04 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/069 (20130101) C12N 5/0607 (20130101) C12N 5/0657 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5061 (20130101) G01N 33/5064 (20130101) G01N 33/5088 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20220195421 — BISTABLE POLYNUCLEOTIDE DEVICES FOR THE SENSING AND QUANTIFICATION OF MOLECULAR EVENTS
| US 20220195421 | Gopinath et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ashwin Gopinath (Pasadena, California); Paul W.K. Rothemund (Pasadena, California) |
| ABSTRACT | Bistable devices are constructed using a polynucleotide platform for the sensing of molecular events such as binding or conformational changes of target molecules. Uses include measurement of target concentration, measuring the effect of environmental condition (such as heat, light, or pH) on the target, or screening a library for molecules that bind the target or modulate its biological function. Devices comprise three regions: a top lid, bottom lid, and flexible linker or hinge between them. A device has an open configuration in which the top and bottom lid are separated, and a closed configuration they are bound close together. Binding domains or variations of the target molecule are fixed to a device so that when the molecular event occurs, the device switches from open to closed, or vice versa, which generates a signal. Devices carry DNA tags to enable separation of open and closed devices, as well as barcoding for multiplexed detection. |
| FILED | Friday, December 03, 2021 |
| APPL NO | 17/542224 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 2525/30 (20130101) C12Q 2525/197 (20130101) C12Q 2525/205 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/573 (20130101) G01N 33/5308 (20130101) G01N 2333/705 (20130101) G01N 2333/912 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195530 | Diehn et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Maximilian Diehn (San Carlos, California); Arash Ash Alizadeh (San Mateo, California); Aaron M. Newman (Palo Alto, California); Scott V. Bratman (Palo Alto, California) |
| ABSTRACT | Methods for creating a selector of mutated genomic regions and for using the selector set to analyze genetic alterations in a cell-free nucleic acid sample are provided. The methods can be used to measure tumor-derived nucleic acids in a blood sample from a subject and thus to monitor the progression of disease in the subject. The methods can also be used for cancer screening, cancer diagnosis, cancer prognosis, and cancer therapy designation. |
| FILED | Thursday, August 19, 2021 |
| APPL NO | 17/406948 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6827 (20130101) C12Q 1/6855 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/156 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 30/00 (20190201) G16B 30/10 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20220195547 — OPTIMIZED GAMMA-PRIME STRENGTHENED AUSTENITIC TRIP STEEL AND DESIGNING METHODS OF SAME
| US 20220195547 | Wengrenovich et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas J. Wengrenovich (Evanston, Illinois); Gregory B. Olson (Riverswood, Illinois) |
| ABSTRACT | An optimized Gamma-prime (γ′) strengthened austenitic transformation induced plasticity (TRIP) steel comprises a composition designed and processed such that the optimized γ′ strengthened austenitic TRIP steel meets property objectives comprising a yield strength of 896 MPa (130 ksi), and an austenite stability designed to have Msσ(sh)=−40° C., wherein Msσ(sh) is a temperature for shear, and wherein the property objectives are design specifications of the optimized γ′ strengthened austenitic TRIP steel. The optimized γ′ strengthened austenitic TRIP steel is Blastalloy TRIP 130. |
| FILED | Wednesday, January 05, 2022 |
| APPL NO | 17/568835 |
| CURRENT CPC | Modifying the Physical Structure of Ferrous Metals; General Devices for Heat Treatment of Ferrous or Non-ferrous Metals or Alloys; Making Metal Malleable, e.g by Decarburisation or Tempering C21D 6/02 (20130101) Original (OR) Class C21D 6/004 (20130101) C21D 7/13 (20130101) C21D 2211/001 (20130101) C21D 2211/004 (20130101) Alloys C22C 38/06 (20130101) C22C 38/44 (20130101) C22C 38/46 (20130101) C22C 38/50 (20130101) C22C 38/54 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195549 | Chung et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yip-Wah Chung (Wilmette, Illinois); Qian Wang (Mt. Prospect, Illinois); Arman Mohammad Khan (Evanston, Illinois); Tobias Vela Martin (Evanston, Illinois) |
| ABSTRACT | Methods for forming carbon-based lubricious and/or wear-protective films in situ on the surface of steel alloys are provided. The methods use chromium-containing steel alloys, molybdenum-containing steel alloys, and steel alloys that contain both copper and nickel. When such alloys are subjected to a rubbing motion in the presence of a hydrocarbon fluid, the chromium, molybdenum, copper, and nickel in the steel alloy catalyzes the formation of solid carbon-containing films that reduce the friction, wear, or both of the contacting surfaces. |
| FILED | Tuesday, December 14, 2021 |
| APPL NO | 17/550951 |
| CURRENT CPC | Modifying the Physical Structure of Ferrous Metals; General Devices for Heat Treatment of Ferrous or Non-ferrous Metals or Alloys; Making Metal Malleable, e.g by Decarburisation or Tempering C21D 1/58 (20130101) C21D 1/60 (20130101) C21D 1/613 (20130101) C21D 8/0205 (20130101) C21D 8/0278 (20130101) Original (OR) Class C21D 2211/001 (20130101) Alloys C22C 38/22 (20130101) C22C 38/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195924 | Luz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James John Luz (Tewksbury, Massachusetts); Robert Burton Brown (Medford, Massachusetts); Thomas Bradley Kenney (Ashby, Massachusetts); Thomas Charles McCarthy (Boston, Massachusetts); Firas Younes (Randolph, Massachusetts) |
| ABSTRACT | A system for lubricating components of a gas turbine engine includes a supply pump to pump lubricant from a reservoir through a supply conduit to lubricated component. An outer body deicing circuit is fluidly coupled in series with the supply conduit. Moreover, a scavenge conduit extends from the lubricated component to the reservoir and a scavenge pump pumps the lubricant from the lubricated component through the scavenge conduit. In addition, a valve is fluidly coupled in series with the supply conduit and the scavenge conduit and a bypass conduit extends from the valve to a location on the supply conduit downstream of the deicing circuit. When the lubricant is supplied to the valve, the valve directs the lubricant flowing through the scavenge conduit into the reservoir. When the supply of lubricant to the valve is halted, the valve directs the lubricant flowing through the scavenge conduit into the bypass conduit. |
| FILED | Tuesday, December 22, 2020 |
| APPL NO | 17/130802 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 25/20 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/06 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2240/35 (20130101) F05D 2260/98 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195980 | Alexander et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Virginia Tech Intellectual Properties, Inc. (Blacksburg, Virginia) |
| ASSIGNEE(S) | Virginia Tech Intellectual Properties, Inc. (Blacksburg, Virginia) |
| INVENTOR(S) | William Nathan Alexander (Blacksburg, Virginia); William J. Devenport (Blacksburg, Virginia); Ian A. Clark (Blacksburg, Virginia); Justin W. Jaworski (Blacksburg, Virginia); Stewart Glegg (Blacksburg, Virginia); Nigel Peake (Blacksburg, Virginia); Conor Daly (Blacksburg, Virginia) |
| ABSTRACT | The present invention relates to airfoils having surface treatments to reduce trailing edge noise. The surface treatment is designed to reduce trailing edge noise by modifying the boundary layer turbulence as it approaches the trailing edge. The surface treatment accomplishes its function by breaking up spanwise-oriented turbulence approaching the trailing edge, thereby reducing the spanwise correlation lengthscales; deflecting the boundary layer turbulence away from the edge; and/or creating spanwise vortices or instability waves to reduce the turbulence-edge interaction. |
| FILED | Saturday, January 08, 2022 |
| APPL NO | 17/571481 |
| CURRENT CPC | Wind Motors F03D 1/0633 (20130101) Original (OR) Class F03D 1/0675 (20130101) Indexing Scheme Relating to Wind, Spring, Weight, Inertia or Like Motors, to Machines or Engines for Liquids Covered by Subclasses F03B, F03D and F03G F05B 2240/30 (20130101) F05B 2260/962 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/72 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220196169 | Chua et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Palo Alto Research Center Incorporated (Palo Alto, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher L. Chua (San Jose, California); Julie Ann Bert (Palo Alto, California); Steven Neltner (San Carlos, California); Emily Coker (Oakland, California) |
| ABSTRACT | An apparatus comprises a frangible structure coupled or integral to at least a portion of the apparatus and a triggerable mechanism disposed at or proximate the frangible structure. The triggerable mechanism is configured to break the frangible structure in response to a trigger signal. A containment structure is disposed on or over at least a portion of the frangible structure. The containment structure is configured to allow at least the portion of the frangible structure to deform or change shape in response to breaking of the frangible structure while keeping substantially all fragments of at least the portion of the broken frangible structure together. |
| FILED | Monday, December 21, 2020 |
| APPL NO | 17/129344 |
| CURRENT CPC | Launching, Hauling-out, or Dry-docking of Vessels; Life-saving in Water; Equipment for Dwelling or Working Under Water; Means for Salvaging or Searching for Underwater Objects B63C 9/00 (20130101) Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 13/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220196356 | Thomas et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America as represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Whitfield Thomas (Moncks Corner, South Carolina); John Sheldon Haynes (Goose Creek, South Carolina) |
| ABSTRACT | The system and method taught herein allow a user to quickly determine how much inventory of a particular type is stored in nearby containers. Rather than inspect each container individually, a user need only scan the area for nearby containers. Each container will respond with its unique identifier and the number of items it contains. |
| FILED | Tuesday, December 22, 2020 |
| APPL NO | 17/130245 |
| CURRENT CPC | Functional Features or Details Common to Both Smallarms and Ordnance, e.g Cannons; Mountings for Smallarms or Ordnance F41A 9/62 (20130101) Original (OR) Class Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 7/10366 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220196635 | Robinson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen Robinson (Atlanta, Georgia); Jonathan Chang (Atlanta, Georgia); Shuichi Takayama (Atlanta, Georgia) |
| ABSTRACT | An exemplary embodiment of the present disclosure provides A method and system for forming a microscale cell-laden matrix using an aqueous two-phase system (“ATPS”) comprising a mixture of a first material and a second material having a phase boundary between the first and second materials. The method can comprise mixing an enzyme with the first material, mixing a protein with the second material, and mixing a suspension comprising cells with one of the first material or the second material, wherein the enzyme, protein, and suspension comprising cells generate the cell-laden matrix and wherein the first material comprises a first polymer comprising polyethylene glycol and the second material can be a second polymer selected from the group consisting of dextran, polyvinyl pyrrolidone, polyvinyl alcohol, or ficoll. |
| FILED | Friday, October 29, 2021 |
| APPL NO | 17/514264 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 21/18 (20130101) C12M 23/16 (20130101) C12M 23/22 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0656 (20130101) C12N 9/6429 (20130101) C12N 2533/54 (20130101) C12N 2533/56 (20130101) Enzymes C12Y 304/21005 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/30 (20130101) G01N 33/5044 (20130101) Original (OR) Class G01N 2800/52 (20130101) G01N 2800/7052 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220196823 | Burke |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Burke (Boston, Massachusetts) |
| ABSTRACT | A phase Doppler radar system may comprise a pulse Doppler receiver/transmitter (R/T) subsystem coupled with a processing subsystem. The system may determine target velocity and target detection events by collecting pulses from the pulse Doppler R/T subsystem, determine an undifferentiated phase of each of the pulses, differentiate the pulses, and determine a differentiated phase of each of the pulses. The system may perform a linear fit of the differentiated phases of the pulses to produce a slope and an intercept. The system may determine a set of initial estimates of coefficients of a nonlinear fit equation. The system may perform iterations of a nonlinear least squares fit, beginning with the initial coefficient estimates, to produce a non-linear fit result. The system may determine a goodness-of-fit (GoF) statistic associated with the nonlinear fit result, and declare a detection event when the GoF is superior to a GoF statistic associated Gaussian noise. |
| FILED | Wednesday, October 10, 2018 |
| APPL NO | 16/156411 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/415 (20130101) G01S 7/2921 (20130101) G01S 13/53 (20130101) Original (OR) Class G01S 13/5244 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220196913 | Winters et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNM Rainforest Innovations (Albuquerque, New Mexico) |
| ASSIGNEE(S) | UNM Rainforest Innovations (Albuquerque, New Mexico) |
| INVENTOR(S) | Nathan Jack Winters (Albuquerque, New Mexico); Marek Osinski (Albuquerque, New Mexico) |
| ABSTRACT | A semiconductor photodetector comprising a closed loop configured to receive light from an external source adapted to trap light within said closed loop until absorption by the semiconductor. |
| FILED | Tuesday, December 21, 2021 |
| APPL NO | 17/558468 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/1225 (20130101) G02B 6/12007 (20130101) Original (OR) Class G02B 6/29338 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220196929 | Toda |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Asako Toda (Santa Clara, California) |
| ABSTRACT | Embodiments disclosed herein include optical packages. In an embodiment, an optical package comprises a package substrate, a compute die over the package substrate, and an optics die over the package substrate. In an embodiment, the optics die comprises grating couplers. In an embodiment, an optical connector for optically coupling optical fibers to the grating couplers is provided. In an embodiment, the optical connector comprises a fiber array unit (FAU), where the FAU has a turn. In an embodiment, the optical connector further comprises a fiber shuffler, where the fiber shuffler comprises a first V-groove with a first depth and a second V-groove with a second depth that is greater than the first depth. In an embodiment, the optical connector further comprises a ferrule. |
| FILED | Thursday, December 17, 2020 |
| APPL NO | 17/125513 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/43 (20130101) G02B 6/3676 (20130101) G02B 6/3897 (20130101) Original (OR) Class G02B 6/4204 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220196935 | LI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaoqian LI (Chandler, Arizona); Nitin DESHPANDE (Chandler, Arizona); Omkar KARHADE (Chandler, Arizona); Asako TODA (Santa Clara, California); Divya PRATAP (Hillsboro, Oregon); Zhichao ZHANG (Chandler, Arizona) |
| ABSTRACT | Embodiments disclosed herein include photonics packages. In an embodiment, a photonics package comprises a package substrate, and a compute die over the package substrate. In an embodiment, a photonics die is also over the package substrate, and the photonics die overhangs an edge of the package substrate. In an embodiment, an integrated heat spreader (IHS) is over the compute die and the photonics die, and a fiber connector is coupled to the photonics die. In an embodiment, the fiber connector is attached to the IHS |
| FILED | Tuesday, December 22, 2020 |
| APPL NO | 17/131682 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/423 (20130101) G02B 6/4214 (20130101) Original (OR) Class G02B 6/4268 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220196936 | HOSSEINI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kaveh HOSSEINI (San Jose, California); Xiaoqian LI (Chandler, Arizona); Conor O'KEEFFE (Cork, Iran); Jing FANG (Santa Clara, California); Kevin P. MA (Beaverton, Oregon); Shamsul ABEDIN (Portland, Oregon) |
| ABSTRACT | Embodiments described herein may be related to apparatuses, processes, and techniques related to a bidirectional optical grating coupler that may be used for testing. A photonic apparatus includes a first layer with electro-optical circuitry that is optically coupled with a bidirectional optical grating coupler. A second layer is physically coupled with a first side of the first layer and includes a first light path to optically coupled with the bidirectional optical grating coupler. A third layer is physically coupled with a second side of the first layer opposite the first side of the first layer, and includes a second light path that optically couples with the bidirectional grating coupler. Operational testing of the electro-optical circuitry is based in part on light received or transmitted through the second light path. Other embodiments may be described and/or claimed. |
| FILED | Wednesday, December 23, 2020 |
| APPL NO | 17/132967 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/4214 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 22/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220197044 | HOSSEINI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kaveh HOSSEINI (San Jose, California); Conor O'KEEFFE (Cork, Iran); Brandon C. MARIN (Gilbert, Arizona); Hiroki TANAKA (Chandler, Arizona) |
| ABSTRACT | Embodiments described herein may be related to apparatuses, processes, and techniques related to a dual polarization chiplet that may be used by an optical receiver to split multi-polarized light traveling on a single fiber and carrying two or more light signals into two or more fibers each carrying the particular light signal. The dual polarization chiplet may also be used by an optical transmitter to combine multiple light signals to be transmitted onto a single fiber, where each of the multiple light signals are represented by a different polarization of a wavelength on the single fiber. Other embodiments may be described and/or claimed. |
| FILED | Tuesday, December 22, 2020 |
| APPL NO | 17/131714 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/0005 (20130101) G02B 6/105 (20130101) G02B 6/2766 (20130101) G02B 27/283 (20130101) Original (OR) Class G02B 27/286 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220197225 | TRUSHEIM et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Matthew Edwin TRUSHEIM (Cambridge, Massachusetts); Kurt JACOBS (Columbia, Maryland); Jonathan HOFFMAN (Greenbelt, Maryland); Donald FAHEY (Washington, District of Columbia); Dirk Robert ENGLUND (Brookline, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Matthew Edwin TRUSHEIM (Cambridge, Massachusetts); Kurt JACOBS (Columbia, Maryland); Jonathan HOFFMAN (Greenbelt, Maryland); Donald FAHEY (Washington, District of Columbia); Dirk Robert ENGLUND (Brookline, Massachusetts) |
| ABSTRACT | An ensemble of spin defect centers or other atom-like quantum systems in a solid-state host can be used as a compact alternative for an atomic clock thanks to an architecture that overcomes magnetic and temperature-induced systematics. A polariton-stabilized solid-state spin clock hybridizes a microwave resonator with a magnetic-field-insensitive spin transition within the ground state of a spin defect center (e.g., a nitrogen vacancy center in diamond). Detailed numerical and analytical modeling of this polariton-stabilized solid-state spin clock indicates a potential fractional frequency instability below 10-13 over a 1-second measurement time, assuming present-day experimental parameters. This stability is a significant improvement over the state-of-the-art in miniaturized atomic vapor clocks. |
| FILED | Monday, October 18, 2021 |
| APPL NO | 17/504238 |
| CURRENT CPC | Time-interval Measuring G04F 5/14 (20130101) Original (OR) Class Automatic Control, Starting, Synchronisation, or Stabilisation of Generators of Electronic Oscillations or Pulses H03L 7/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220197599 | Cambou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of Northern Arizona University (Flagstaff, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bertrand F. Cambou (Flagstaff, Arizona); Sareh Assiri (Flagstaff, Arizona); Michael L. Garrett (Flagstaff, Arizona); Saloni Jain (Flagstaff, Arizona); Michael Partridge (Flagstaff, Arizona) |
| ABSTRACT | The use of pre-formed arrays of memristors such as ReRAMs for true random number generation is disclosed. The method exploits the natural randomness in the large stochastic cell-to-cell variations in resistance values at low injected current in the pre-formed range. This novel TRNG scheme can be designed with three interconnected blocks: i) a pseudo-random number generator (PRNG) that is acting as an extended output function (XOF) to generate a stream of addresses pointing randomly at the array of ReRAM cells; ii) a method to read the resistance values of these cells at low injected current and convert the values in a stream of random bits; and, if needed, iii) methods to further enhance the randomness of this stream such as, but not limited to, mathematical, Boolean, and cryptographic algorithms. |
| FILED | Wednesday, December 22, 2021 |
| APPL NO | 17/559454 |
| CURRENT CPC | Electric Digital Data Processing G06F 7/582 (20130101) Original (OR) Class Static Stores G11C 13/0023 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220197738 | Nelson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Honeywell International Inc. (Charlotte, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David K. Nelson (Medicine Lake, Minnesota); Robert Rabe (Chanhassen, Minnesota); Keith Golke (Minneapolis, Minnesota) |
| ABSTRACT | A method for storing data includes determining, using a first match line, that a match word satisfies a first content addressable memory (CAM) word stored in a CAM array, wherein the CAM array is configured to store a second CAM word that matches the first CAM word. The method further includes determining that a first parity bit associated with the first CAM word matches a first parity of the first CAM word. The method further includes, in response to determining that the first parity bit associated with the first CAM word matches the first parity determining, using the first match line, a first random access memory (RAM) word stored in a RAM array and outputting the first RAM word. |
| FILED | Wednesday, October 13, 2021 |
| APPL NO | 17/450716 |
| CURRENT CPC | Electric Digital Data Processing G06F 11/1004 (20130101) Original (OR) Class Static Stores G11C 15/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220197881 | Dutertre et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SRI International (Menlo Park, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bruno Dutertre (Mountain View, California); Susmit Jha (Redwood City, California); Huascar Sanchez (San Ramon, California); Patrick Lincoln (Woodside, California); Eric M. Pearson (Redwood City, California); Richard Dean (Los Altos, California); Ian A. Mason (La Selva Beach, California) |
| ABSTRACT | Processing circuitry is configured to obtain a data structure that defines a plurality of conversions of data between pairs of fields; perform a search to identify a plurality of paths from a source node of the data structure to a destination node of the data structure, wherein the source node corresponds to a first field of the fields and the destination node corresponds to a second field of the fields; convert, for each path of the plurality of paths, transforms represented by corresponding edges of the path to a sequence of transforms that conform to a solver format; process the sequence of transforms for each path to determine whether all paths of the plurality of paths are equivalent up to an equivalence relation; and output an indication of whether all paths of the plurality of paths are equivalent up to an equivalence relation. |
| FILED | Friday, December 17, 2021 |
| APPL NO | 17/644946 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/22 (20190101) Original (OR) Class G06F 16/2433 (20190101) G06F 16/24534 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220197982 | Cron et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Synopsys, Inc. (Mountain View, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam Cron (Hillton Head Island, South Carolina); Andrew Elias (Ottawa, Canada); Bandi Chandra Sekhar Reddy (Union City, California); Michael Borza (Ottawa, Canada) |
| ABSTRACT | Some aspects of this disclosure are directed to implementing hardware-based obfuscation of digital data. For example, some aspects of this disclosure relate to a method, including performing a capture operation that loads a plurality of primary input (PI) bits into corresponding shift registers of a plurality of test data registers (TDRs) disposed on one or more digital semiconductor devices and configured to store a plurality of secret information bits. The method further includes performing a sequence of shift operations on the plurality of TDRs to obtain a plurality of output bits. The method further includes applying, by an authenticating processor, a derivation function on the plurality of output bits to extract the plurality of secret information bits thereby authenticating the one or more digital semiconductor devices. |
| FILED | Tuesday, December 21, 2021 |
| APPL NO | 17/558389 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/14 (20130101) Original (OR) Class G06F 21/73 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220198018 | Wentz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ares Technologies, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Ares Technologies, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Christian Wentz (San Francisco, California); Ilia Lebedev (Cambridge, Massachusetts); Anna Lysyanskaya (Providence, Rhode Island) |
| ABSTRACT | A system for a cryptographic agile bootloader for upgradable secure computing environment, the cryptographic agile bootloader comprising a computing device associated with a first bootloader is presented. The computing device includes a secure root of trust, the secure root of trust configured to produce a first secret and a second secret and a processor. The processor is configured to load a second bootloader, wherein the second bootloader is configured to generate a secret-specific public datum as a function of the second secret, wherein the secret-specific public datum further comprises a bootloader measurement, load a first bootloader, wherein the first bootloader is configured to sign the secret-specific public datum as a function of the first secret, and replace the first bootloader with the second bootloader. |
| FILED | Thursday, October 28, 2021 |
| APPL NO | 17/513059 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/572 (20130101) Original (OR) Class G06F 2221/033 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/3247 (20130101) H04L 9/3268 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220198100 | KERMAN |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew J. KERMAN (Arlington, Massachusetts) |
| ABSTRACT | In accordance with dissipative, photon-assisted quantum annealing described herein, a collection of qubits model a Boolean optimization problem, and the solution is determined by quantum annealing. However, rather than drive the qubits using a quasi-static field transverse to the computational direction, spins are allowed to evolve between computational states by multi-photon, inelastic collective scattering into a common waveguide coupled transversely to all of the qubits. Transitions between arbitrary states are enabled by the continuum of modes of the waveguide, while avoiding the exponential sensitivity to low-frequency decoherence near small gaps which is inherent in conventional QA. Moreover, because the transverse coupling to the waveguide averages to zero, the spin of each qubit experiences a net field purely in the computational direction, allowing continuous, quantum non-demolition measurement of the system. |
| FILED | Wednesday, November 10, 2021 |
| APPL NO | 17/523601 |
| CURRENT CPC | Optical Computing Devices; G06E 1/00 (20130101) Electric Digital Data Processing G06F 30/20 (20200101) Original (OR) Class G06F 2111/08 (20200101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220198266 | Chakraborty et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | INTERNATIONAL BUSINESS MACHINES CORPORATION (ARMONK, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Supriyo Chakraborty (White Plains, New York); Seraphin Bernard Calo (Cortlandt Manor, New York); Jiawei Wen (State College, Pennsylvania) |
| ABSTRACT | A method and system of training an interpretable deep learning model includes receiving an input set of data, which may be complex. The input set of data is provided to deep learning model for feature extraction. In an exemplary embodiment, the deep learning model generates a disentangled latent space of features from the feature extraction. The features may comprise semantically meaningful data which is then provided to a low-complexity learning model. The low-complexity learning model generates output based on a specified task (for example, classification or regression). Being a low-complexity learning model provides confidence that the data output from the deep learning model is inherently interpretable. |
| FILED | Wednesday, December 23, 2020 |
| APPL NO | 17/133437 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/726 (20130101) G06K 9/6251 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Original (OR) Class G06N 3/0472 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220198290 | Rubin |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America as represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stuart H. Rubin (San Diego, California) |
| ABSTRACT | An artificial intelligence system and a method for its operation include rule bases established to maintain rules for respective knowledge domains. A network links the rule bases together. A first rule in every rule base references a second rule in another rule base via the network, and the network at least interconnects every first and second rule bases for which the first rule in the first rule base references the second rule in the second rule base. The artificial intelligence system is adapted to invoke a third one of the rules of a particular one of the rule bases in response to an input from a user of the artificial intelligence system, and this begins a chain invoking the rules of the rule bases via the network. The chain includes the first rule in one of the rule bases invoking the second rule in another one of the rule bases. |
| FILED | Thursday, December 17, 2020 |
| APPL NO | 17/125062 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/243 (20190101) Computer Systems Based on Specific Computational Models G06N 5/022 (20130101) G06N 5/025 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220198308 | KUMAR et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mrinal KUMAR (Columbus, Ohio); Chao YANG (Columbus, Ohio) |
| ABSTRACT | Forecasting is built around an adaptive particle approach, which may be classified under the broad umbrella of Monte Carlo methods. Performance can be self-monitoring, and an ensemble can be adaptively modified to maintain performance within prescribed bounds. If underperforming, additional particles can be added until performance is again within the prescribed bounds. If overperforming, particles can optionally be removed until performance is within the prescribed bounds. |
| FILED | Thursday, May 21, 2020 |
| APPL NO | 17/605840 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 7/005 (20130101) Original (OR) Class G06N 20/20 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220198941 | Tao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qiuyang Tao (Atlanta, Georgia); Tony X. Lin (Atlanta, Georgia); Junkai Wang (Atlanta, Georgia); Zheyuan Xu (Atlanta, Georgia); Fumin Zhang (Atlanta, Georgia) |
| ABSTRACT | A robotic system includes a robot, a motion capture system and a ground station. The robot includes motors, a transceiver, an actuation circuit that receives an actuation command data packet from the transceiver and controls actuation of the motors. The motion capture system tracks a position and attitude of the robot and generates position and attitude data. The ground station is in wireless data communication with the transceiver and is in data communication with the motion capture system. The ground station receives the position and attitude data from the motion capture system; calculates a desired actuation for the robot; generates actuation command data packets for effecting the desired actuation. The actuation command data packets are transmitted wirelessly to the robot transceiver. The robot actuates the plurality motors upon receiving the actuation command data packet. |
| FILED | Thursday, November 11, 2021 |
| APPL NO | 17/524182 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 39/024 (20130101) B64C 2201/108 (20130101) B64C 2201/143 (20130101) Image Data Processing or Generation, in General G06T 7/70 (20170101) G06T 7/292 (20170101) G06T 2207/30252 (20130101) Traffic Control Systems G08G 5/0013 (20130101) Original (OR) Class G08G 5/0043 (20130101) G08G 5/0069 (20130101) Wireless Communication Networks H04W 4/33 (20180201) H04W 4/40 (20180201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220199147 | Golke |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Honeywell International Inc. (Charlotte, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Keith Golke (Minneapolis, Minnesota) |
| ABSTRACT | An apparatus for reading a bit of a memory array includes a bit cell column, voltage enhancement circuitry, and control circuitry. The voltage enhancement circuitry is configured to couple a bitline to a reference node. The control circuitry is configured to, in response to a read request for a bitcell element of a plurality of bitcell elements, couple a current source to the bitcell column such that a read current from the current source flows from the source line, through the bitcell column and the voltage enhancement circuitry, to the reference node and determine a state for the bitcell element based on a voltage between the source line and the reference node. The voltage enhancement circuitry is configured to generate, when the read current flows through the voltage enhancement circuitry, a voltage at the bitline that is greater than a voltage at the reference node. |
| FILED | Friday, October 08, 2021 |
| APPL NO | 17/497483 |
| CURRENT CPC | Static Stores G11C 11/4074 (20130101) G11C 11/4094 (20130101) Original (OR) Class G11C 11/4099 (20130101) G11C 17/126 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220199227 | Reifman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States, as represented by the Secretary of the Army (Fort Detrick, Maryland) |
| ASSIGNEE(S) | The Government of the United States, as represented by the Secretary of the Army (Fort Detrick, Maryland) |
| INVENTOR(S) | Jaques Reifman (New Market, Maryland); Sridhar Ramakrishnan (Frederick, Maryland); Thomas J. Balkin (Silver Spring, Maryland); Francisco G. Vital-Lopez (Frederick, Maryland) |
| ABSTRACT | A system and method using a biomathetical model in conjunction with an optimization method for an individuals alertness impairment at a future time based on a known sleep schedule by adjusting the intake of caffeine over that schedule. In a further embodiment, placing constraints on the frequency, the dose amount, and/or total amount consumed over the course of the future schedule. In a further embodiment, optimizing the sleep schedule (prior to or independent of caffeine optimization) to decrease the individuals alertness impairment at the future time(s). In a further embodiment, adjust both the sleep schedule and caffeine intake to decrease the individuals alertness impairment at the future time(s). In at least one embodiment, the system including a mobile based system and/or a networked computer-based system. |
| FILED | Thursday, April 16, 2020 |
| APPL NO | 17/603854 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/20 (20200101) G06F 2111/10 (20200101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/10 (20180101) G16H 20/70 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220199281 | Ganguli et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sabyasachi Ganguli (Beavercreek, Ohio); Ajit K Roy (Beavercreek, Ohio); Chenggang Chen (Beavercreek, Ohio) |
| ABSTRACT | An electrically conductive, flexible, strain resilient product is produced by mixing metal coated carbon nanotube networks with a liquid polymeric resin to produce a liquid mixture, and the mixture is cured to produce the product. The networks may include welded junctions between nanotubes formed by depositing and melting metal nanoparticles on the nanotubes to form the metal coating. After the mixing step the liquid mixture may be deposited on a flexible substrate in the form of an electrical circuit. The mixing step may further include mixing the composite with a volatile solvent to produce a selected viscosity. Then, a three-dimensional printer may be used to print the product, such as an electrical circuit, on a substrate. The product is cured in an atmosphere that absorbs the solvent. The conductivity of the mixture may be adjusted by adjusting the weight percentage of the metal coated carbon nanotube networks from 50% to 90%, but a preferred range is between 75% and 85%. |
| FILED | Tuesday, March 15, 2022 |
| APPL NO | 17/695144 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220199384 | Cooks et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Graham Cooks (West Lafayette, Indiana); Guangtao Li (Carmel, Indiana); Guangming Huang (West Lafayette, Indiana); Jason Duncan (Dayton, Indiana); Xin Li (West Lafayette, Indiana); Ewa Sokol (West Lafayette, Indiana); Xin Yan (West Lafayette, Indiana) |
| ABSTRACT | The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface. |
| FILED | Thursday, July 16, 2020 |
| APPL NO | 16/930388 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/62 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/0018 (20130101) H01J 49/045 (20130101) Original (OR) Class H01J 49/0445 (20130101) Technical Subjects Covered by Former US Classification Y10T 436/24 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220199845 | Song et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Toledo (Toledo, Ohio) |
| ASSIGNEE(S) | The University of Toledo (Toledo, Ohio) |
| INVENTOR(S) | Zhaoning Song (Toledo, Ohio); Kamala Khanal Subedi (Toledo, Ohio); Randy Ellingson (Toledo, Ohio); Yanfa Yan (Toledo, Ohio) |
| ABSTRACT | An optoelectronic device comprising two photovoltaic absorber materials of CdSeTe and perovskite and their functional component layers that are monolithically integrated into a bifacial tandem solar cell structure. |
| FILED | Thursday, November 18, 2021 |
| APPL NO | 17/529682 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/073 (20130101) Original (OR) Class H01L 31/1884 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220200231 | Garay et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Javier E. Garay (San Diego, California); Elias H. Penilla (Upland, California); Yasuhiro Kodera (San Diego, California) |
| ABSTRACT | A laser apparatus and a polycrystalline material are described. The apparatus includes the polycrystalline material which is configured to receive pumping light at a pump wavelength and to produce an optical gain for laser oscillation at a laser wavelength different from the pump wavelength. The polycrystalline material includes a ceramic material with a predetermined grain size. The polycrystalline material further includes a rare earth dopant with a predetermined concentration, wherein the predetermined grain size and the predetermined concentration cause the polycrystalline material to exhibit the optical gain at the laser wavelength. |
| FILED | Friday, January 24, 2020 |
| APPL NO | 17/425940 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/7758 (20130101) C09K 11/7774 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/1611 (20130101) H01S 3/1636 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20220193596 | Nguyen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Du T. Nguyen (Fremont, California); Sarah E. Baker (Dublin, California); William L. Bourcier (Livermore, California); Joshua K. Stolaroff (Oakland, California); Congwang Ye (San Ramon, California); Maxwell R. Murialdo (Westminister, California); Maira R. Cerón Hernández (Brentwood, California); Jennifer M. Knipe (Oakland, California) |
| ABSTRACT | A composite material for gas capture including CO2 capture and capture of other gases. The composite material includes solid or liquid reactive material, filler material, and a gas-permeable polymer coating such that the reactive material forms micron-scale domains in the filler material. |
| FILED | Thursday, March 10, 2022 |
| APPL NO | 17/691788 |
| CURRENT CPC | Separation B01D 53/04 (20130101) Original (OR) Class B01D 53/1493 (20130101) B01D 2253/25 (20130101) B01D 2257/504 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/28019 (20130101) B01J 20/28023 (20130101) B01J 20/28026 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/118 (20170801) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2995/0065 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193642 | HABIB et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Habib Technologies LLC (Lancaster, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Youssef M. HABIB (Lancaster, Pennsylvania); Abraham ULMAN (Brooklyn, New York) |
| ABSTRACT | A method for producing plasmonic nanomaterials that are catalytically or photocatalytically active by fabricating plasmonic nanostructures on substrates using electrodeposition into a nano-template structure and forming a plurality of nanorods in an array, wherein the nanorods are made from materials chosen from the group consisting of materials that are plasmonic and/or catalytic, and materials that are catalytically activated by depositing pure elemental metals, alloys, or alternating layers of different metals or alloys, and producing catalytic plasmonic nanomaterials. Catalytic plasmonic nanomaterials made from the above method. An optical reactor device that utilizes catalytic nanomaterials for photocatalytic synthesis of methanol or ammonia. A method of photocatalytic synthesis of methanol and ammonia by using catalytic plasmonic nanomaterial to convert CO2 and H2 to methanol and N2 and H2 to ammonia using optical power. A hybrid plasma-plasmonic reactor for the utilization of CO2 and CH4 to produce methanol, ethylene, and acetic acid. |
| FILED | Tuesday, February 25, 2020 |
| APPL NO | 17/428794 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 15/00 (20130101) B01J 19/006 (20130101) B01J 19/127 (20130101) B01J 21/02 (20130101) B01J 21/063 (20130101) B01J 23/50 (20130101) B01J 23/8926 (20130101) Original (OR) Class B01J 35/004 (20130101) B01J 35/04 (20130101) B01J 35/0013 (20130101) B01J 35/0033 (20130101) B01J 37/0225 (20130101) B01J 37/0228 (20130101) B01J 37/0244 (20130101) B01J 37/348 (20130101) B01J 2219/00763 (20130101) B01J 2219/0875 (20130101) B01J 2219/0892 (20130101) B01J 2219/1203 (20130101) Ammonia; Cyanogen; Compounds Thereof C01C 1/0411 (20130101) C01C 1/0417 (20130101) Acyclic or Carbocyclic Compounds C07C 29/157 (20130101) C07C 31/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193936 | Dilday, JR. et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Daniel R. Dilday, JR. (Plainfield, Illinois); Roberto T. Reyes (Ottawa, Illinois); Stanley Weidmeyer (Glen Ellyn, Illinois) |
| ABSTRACT | The invention provides a system for preventing fluid exchange between the interior and exterior of containment enclosures such as process-, hazard-, and research-enclosure systems generally, gloveboxes, containment systems, isolation systems, confinement systems, cleanrooms, negative air systems, and positive air system areas while simultaneously providing material transfer into and out of the enclosures. The invention also provides a method for transporting material into or out of a containment structure. |
| FILED | Thursday, March 10, 2022 |
| APPL NO | 17/692029 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 1/02 (20130101) Manipulators; Chambers Provided With Manipulation Devices B25J 21/02 (20130101) Original (OR) Class Protection Against X-radiation, Gamma Radiation, Corpuscular Radiation or Particle Bombardment; Treating Radioactively Contaminated Material; Decontamination Arrangements Therefor G21F 7/047 (20130101) Technical Subjects Covered by Former US Classification Y10T 29/49826 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193959 | SAITO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tomonori SAITO (Oak Ridge, Tennessee); Lu HAN (Oak Ridge, Tennessee); Amelia M. ELLIOTT (Oak Ridge, Tennessee); Dustin B. GILMER (Oak Ridge, Tennessee) |
| ABSTRACT | A washout tooling for a composite layup is provided. The washout tooling comprises a casting mold having an exterior surface. The casting mold comprises a particulate material and a water-soluble binder. The casting mold is adapted to break down in the presence of an aqueous solution. The washout tooling further comprises a water-soluble coating layer overlying the exterior surface. The water-soluble coating layer is adapted to break down in the presence of an aqueous solution. The washout tooling further comprises a curable composite layer overlying the water-soluble coating layer. The water-soluble coating layer minimizes contact between the particulate material and the curable composite layer. |
| FILED | Friday, December 18, 2020 |
| APPL NO | 17/126457 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 33/62 (20130101) Original (OR) Class B29C 33/3842 (20130101) B29C 70/30 (20130101) B29C 70/54 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/002 (20130101) C09D 5/008 (20130101) C09D 7/61 (20180101) C09D 7/70 (20180101) C09D 125/18 (20130101) C09D 133/02 (20130101) C09D 141/00 (20130101) C09D 179/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193988 | Walker et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David A. Walker (Evanston, Illinois); James L. Hedrick, III (Evanston, Illinois); Chad A. Mirkin (Wilmette, Illinois) |
| ABSTRACT | Methods and apparatus comprising a dewetting material and a polymerization liquid that are immiscible and dewetting, and can be used for the formation of three-dimensional objects, wherein the method does not require a dead zone. Additionally, methods and apparatus that employ the use of a flowing dewetting material to provide a shearing interface to reduce interfacial adhesive forces. |
| FILED | Monday, March 09, 2020 |
| APPL NO | 17/436754 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/129 (20170801) Original (OR) Class B29C 64/307 (20170801) B29C 64/357 (20170801) B29C 64/364 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 40/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20220193990 — IN-SITU DIGITAL IMAGE CORRELATION AND THERMAL MONITORING IN DIRECTED ENERGY DEPOSITION
| US 20220193990 | Haley et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Haley (Oak Ridge, Tennessee); Ryan Dehoff (Oak Ridge, Tennessee); Vincent C. Paquit (Oak Ridge, Tennessee); Samuel C. Leach (Oak Ridge, Tennessee) |
| ABSTRACT | A method and a system for digital image correlation and thermal monitoring during directed energy deposition are provided. The method and the system include global off-axis 3D mapping of surfaces features at high frame rates using the natural surface roughness of the additive build. Infrared thermography is projected onto these surface features to record the thermo-mechanical history of the finished component. As set forth herein, the method and the system provide a low-cost solution to monitoring and optimizing the unique temporal artifacts induced by complex scan strategies. |
| FILED | Thursday, December 17, 2020 |
| APPL NO | 17/124569 |
| CURRENT CPC | Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/034 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/153 (20170801) Original (OR) Class B29C 64/386 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) Image Data Processing or Generation, in General G06T 7/80 (20170101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193992 | Mettry et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Magi Mettry (Livermore, California); Juergen Biener (San Leandro, California); James S. Oakdale (Castro Valley, California) |
| ABSTRACT | An optically clear resin for additive manufacturing includes an optically clear ceramic precursor having a pre-defined refractive index. Each molecule of the ceramic precursor has at least two photopolymerizable functional groups, at least one of the photopolymerizable functional groups being functionalized with a refractive index-tuning group thereby causing the ceramic precursor to have the pre-defined refractive index. |
| FILED | Tuesday, December 22, 2020 |
| APPL NO | 17/131353 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/153 (20170801) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 2235/36 (20130101) Optical Elements, Systems, or Apparatus G02B 1/007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220194877 | Achinivu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); NATIONAL TECHNOLOGY AND ENGINEERING SOLUTIONS OF SANDIA, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ezinne Achinivu (Alexandria, Virginia); Mood Mohan (Emeryville, California); Hemant Choudhary (Emeryville, California); Lalitendu Das (Emeryville, California); Venkataramana R. Pidatala (Emeryville, California); Harsha D. Magurudeniya (Newport News, Virginia); Kaixuan Huang (Albany, California); John M. Gladden (Alameda, California); Blake A. Simmons (San Francisco, California) |
| ABSTRACT | The present invention provides for a method to deconstruct a biomass: the method comprising: (a) introducing a solvent comprising a polyamine, or a mixture of polyamines, to a biomass to dissolve at least part of solid biomass in the solvent, wherein the polyamine is a Bronsted or Lewis base, and/or the polyamine is a hydrogen bond donor and/or acceptor; (b) optionally introducing an enzyme and/or a microbe to the solubilized biomass mixture such that the enzyme and/or microbe produces a sugar from the solubilized biomass mixture; (c) optionally separating the sugar from the solubilized biomass mixture; and (d) optionally separating the lignan from the solubilized biomass mixture. |
| FILED | Thursday, December 09, 2021 |
| APPL NO | 17/547134 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 7/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195220 | Sullivan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kyle Sullivan (Pleasanton, California); John M. Densmore (Livermore, California); Eric Duoss (Dublin, California); Alexander E. Gash (Brentwood, California); Joshua Kuntz (Livermore, California); John Vericella (Oakland, California) |
| ABSTRACT | In one embodiment, a method includes dispersing a plurality of particles in a solution to form a dispersion; and adding a stabilizing agent to the dispersion in an amount sufficient to cause the dispersion to exhibit one or more predetermined rheological properties, wherein the particles are characterized by a core-shell configuration, wherein the core-shell configuration includes a core formed from a first material and a shell formed from a second material, wherein the first material and the second material form a combustible composition and/or a reactive binary composition that is configured to complete a self-propagating reaction and/or a self-sustaining reaction upon initiation thereof. Corresponding materials, and methods of using such materials, are also disclosed. |
| FILED | Wednesday, March 09, 2022 |
| APPL NO | 17/691006 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/118 (20170801) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/02 (20130101) Original (OR) Class C09D 11/03 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/24893 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195307 | CHAUHAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | SATYA P. CHAUHAN (Columbus, Ohio); DANIEL B. GARBARK (Blacklick, Ohio) |
| ABSTRACT | Processes for converting the coal-derived heavy-oil fraction of syncrude to polyols are described. The processes involve mixing a feed stream comprising the coal-derived heavy-oil fraction with an alcohol and aqueous sulfuric acid, heating the mixture, reacting the coal-derived heavy-oil fraction with ozone, and reacting the ozonated heavy-oil fraction with glycerin to form the polyol. In some cases, the ozonated heavy-oil fraction can be neutralized before reacting the ozonated heavy-oil fraction with the glycerin. |
| FILED | Wednesday, March 09, 2022 |
| APPL NO | 17/654076 |
| CURRENT CPC | Cracking Hydrocarbon Oils; Production of Liquid Hydrocarbon Mixtures, e.g by Destructive Hydrogenation, Oligomerisation, Polymerisation; Recovery of Hydrocarbon Oils From Oil-shale, Oil-sand, or Gases; Refining Mixtures Mainly Consisting of Hydrocarbons; Reforming of Naphtha; Mineral Waxes C10G 1/002 (20130101) C10G 1/02 (20130101) C10G 1/042 (20130101) C10G 1/045 (20130101) C10G 1/065 (20130101) Original (OR) Class C10G 45/32 (20130101) C10G 45/44 (20130101) C10G 69/06 (20130101) C10G 2300/42 (20130101) C10G 2300/44 (20130101) C10G 2300/107 (20130101) C10G 2300/1011 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 30/20 (20151101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195308 | Thorson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Michael R. Thorson (Richland, Washington); Lesley J. Snowden-Swan (Ellensburg, Washington); Andrew J. Schmidt (Richland, Washington); Todd R. Hart (Kennewick, Washington); Justin M. Billing (Richland, Washington); Daniel B. Anderson (Pasco, Washington); Richard T. Hallen (Richland, Washington) |
| ABSTRACT | A hydrothermal liquefaction (HTL) system can comprise a biomass slurry source, a first pump in fluid communication with the slurry source and configured to pressurize a biomass slurry stream from the slurry source to a first pressure, a first heat exchanger in fluid communication with the first pump and configured to heat a slurry stream received from the first pump to a first temperature, a second pump in fluid communication with the first heat exchanger and configured to pressurize a slurry stream received from the first heat exchanger to a second pressure higher than the first pressure, a second heat exchanger in fluid communication with the second pump and configured to heat a slurry stream received from the second pump to a second temperature higher than the first temperature, and a HTL reactor configured to produce biocrude from a slurry stream received from the second heat exchanger. |
| FILED | Monday, March 14, 2022 |
| APPL NO | 17/654774 |
| CURRENT CPC | Cracking Hydrocarbon Oils; Production of Liquid Hydrocarbon Mixtures, e.g by Destructive Hydrogenation, Oligomerisation, Polymerisation; Recovery of Hydrocarbon Oils From Oil-shale, Oil-sand, or Gases; Refining Mixtures Mainly Consisting of Hydrocarbons; Reforming of Naphtha; Mineral Waxes C10G 1/065 (20130101) Original (OR) Class C10G 2300/1011 (20130101) Fuels Not Otherwise Provided for; Natural Gas; Synthetic Natural Gas Obtained by Processes Not Covered by Subclasses C10G, C10K; Liquefied Petroleum Gas; Adding Materials to Fuels or Fires to Reduce Smoke or Undesirable Deposits or to Facilitate Soot Removal; Firelighters C10L 3/08 (20130101) C10L 2200/0469 (20130101) C10L 2290/06 (20130101) C10L 2290/46 (20130101) C10L 2290/543 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195322 | RUDDY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel RUDDY (Arvada, Colorado); Thomas Dwight FOUST (Evergreen, Colorado); Trenton John WILKE (Seattle, Washington); Anh The TO (Denver, Colorado); Andrew Wolf BARTLING (Golden, Colorado); Martha ARELLANO-TREVINO (Golden, Colorado) |
| ABSTRACT | The present disclosure relates to a composition that includes a compound having the structure R1O—(CH2O)n—R2 and a cetane number between about 65 and about 100, where n is between 1 and 10, inclusively, R1 includes a first alkyl group, and R2 includes a second alkyl group. |
| FILED | Thursday, December 09, 2021 |
| APPL NO | 17/546170 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 41/14 (20130101) Fuels Not Otherwise Provided for; Natural Gas; Synthetic Natural Gas Obtained by Processes Not Covered by Subclasses C10G, C10K; Liquefied Petroleum Gas; Adding Materials to Fuels or Fires to Reduce Smoke or Undesirable Deposits or to Facilitate Soot Removal; Firelighters C10L 1/1852 (20130101) Original (OR) Class C10L 10/06 (20130101) C10L 10/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195447 | Lin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chien-Yuan Lin (Richmond, California); Aymerick Guillaume Eudes (Emeryville, California) |
| ABSTRACT | The present invention provides a genetically modified plant or plant cell comprising a nucleic acid encoding one or more heterologous enzymes operably linked a promoter, wherein one or more heterologous enzymes synthesizes 2-pyrone-4,6-dicarboxylic acid (PDC). |
| FILED | Thursday, October 14, 2021 |
| APPL NO | 17/501896 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8243 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 17/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195666 | Choudhary et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); NATIONAL TECHNOLOGY AND ENGINEERING SOLUTIONS OF SANDIA, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hemant Choudhary (Emeryville, California); Harsha D. Magurudeniya (Newport News, Virginia); John M. Gladden (Alameda, California); Blake A. Simmons (San Francisco, California) |
| ABSTRACT | A method to deconstruct a biomass: the method comprising: introducing a solvent comprising a plurality of salt ionic liquid (PSIL) (such as a double salt ionic liquid (DSIL)) to a biomass to dissolve at least part of solid biomass in the solvent; wherein the PSIL (or DSIL) is an organic salt comprising three or more ions, and the PSIL comprises: (i) a hard anion ionic liquid (IL) and a soft anion IL, (ii) at least one IL having a pKa value of equal to or higher than 10, or (iii) at least one IL has a low hydrogen bond donor ability. |
| FILED | Wednesday, December 22, 2021 |
| APPL NO | 17/560051 |
| CURRENT CPC | Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/14 (20130101) C12P 2201/00 (20130101) Production of Cellulose by Removing Non-cellulose Substances From Cellulose-containing Materials; Regeneration of Pulping Liquors; Apparatus Therefor D21C 3/04 (20130101) D21C 3/20 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220196239 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | West Virginia University Board of Governors on Behalf of West Virginia University (Morgantown, West Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xingbo Liu (Morgantown, West Virginia); Yi Wang (Morgantown, West Virginia); Liang Ma (Morgantown, West Virginia); Wenyuan Li (Morgantown, West Virginia) |
| ABSTRACT | A high temperature carbon monoxide sensor for in-situ combustion monitoring is provided having a yttrium-stabilized zirconia interface based emf-measuring electrochemical sensor and a nickel oxide (NiO) first sensing electrode for targeting carbon monoxide gas at a temperature range from between about 1000 degrees Centigrade to about 1200 degrees Centigrade. A method of measuring carbon monoxide using this sensor is provided. |
| FILED | Wednesday, December 22, 2021 |
| APPL NO | 17/645583 |
| CURRENT CPC | Regulating or Controlling Combustion F23N 5/006 (20130101) Original (OR) Class F23N 5/025 (20130101) F23N 2900/05004 (20130101) F23N 2900/05005 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/30 (20130101) G01N 27/4073 (20130101) G01N 27/4075 (20130101) G01N 33/004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220196263 | WOODS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason David WOODS (Boulder, Colorado); Eric KOZUBAL (Superior, Colorado) |
| ABSTRACT | Integrated systems comprising both i) heat and mass exchange systems and ii) electrolysis stacks are disclosed, together with related methods of use. The disclosed systems cool and/or dehumidify air using two streams of salt solutions as liquid desiccants. |
| FILED | Monday, March 07, 2022 |
| APPL NO | 17/688293 |
| CURRENT CPC | Air-conditioning; Air-humidification; Ventilation; Use of Air Currents for Screening F24F 3/1417 (20130101) Original (OR) Class F24F 13/30 (20130101) F24F 2003/1435 (20130101) F24F 2003/1458 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220196536 | Galbreth et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregory G. Galbreth (Idaho Falls, Idaho); Ammon N. Williams (Rigby, Idaho) |
| ABSTRACT | A measurement system includes a vessel for containing a fluid and at least one solid material and a probe assembly for disposing partially into the fluid within the vessel. The probe assembly includes a hollow tube having an open lower longitudinal end and at least one pressure sensor within the hollow tube, the at least one pressure sensor configured to measure pressures of the fluid within the hollow tube at at least two different elevations. A method of measuring a mass of suspended solids within a fluid the method includes receiving pressure measurements representing two different elevations of the fluid within a hollow tube and substantially free of the suspended solids and based at least partially on the received pressure measurements, determining a mass of the suspended solids. |
| FILED | Wednesday, December 15, 2021 |
| APPL NO | 17/644438 |
| CURRENT CPC | Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/16 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220196548 | MALLERY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | REBELLION PHOTONICS, INC. (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan MALLERY (Houston, Texas); Ohad Israel BALILA (Friendswood, Texas); Robert Timothy KESTER (Friendswood, Texas) |
| ABSTRACT | An infrared (IR) imaging system for determining a concentration of a target species in an object is disclosed. The imaging system can include an optical system including a focal plane array (FPA) unit behind an optical window. The optical system can have components defining at least two optical channels thereof, said at least two optical channels being spatially and spectrally different from one another. Each of the at least two optical channels can be positioned to transfer IR radiation incident on the optical system towards the optical FPA. The system can include a processing unit containing a processor that can be configured to acquire multispectral optical data representing said target species from the IR radiation received at the optical FPA. One or more of the optical channels may be used in detecting objects on or near the optical window, to avoid false detections of said target species. |
| FILED | Thursday, March 10, 2022 |
| APPL NO | 17/654320 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 5/0806 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/314 (20130101) G01N 21/3504 (20130101) Original (OR) Class Pictorial Communication, e.g Television H04N 5/33 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220196583 | Clemenzi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Richard A Clemenzi (Asheville, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard A Clemenzi (Asheville, North Carolina); Garen N Ewbank (Fairview, Oklahoma); Judith A Siglin (Asheville, North Carolina) |
| ABSTRACT | Determination of Ground Thermal Conductivity (TC) in the field of Geothermal Heat Pumps (GHPs). The invention provides a simple mathematical approach using minimal terms with apparatus not dependent on stable electric power generation. |
| FILED | Wednesday, December 23, 2020 |
| APPL NO | 17/133470 |
| CURRENT CPC | Measuring Volume, Volume Flow, Mass Flow or Liquid Level; Metering by Volume G01F 1/662 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 25/18 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220196655 | Hodge et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Curtis D. Hodge (Berkeley, California); Gregory L. Hura (Berkeley, California); Todd O. Yeates (Agoura Hills, California) |
| ABSTRACT | The present invention provides for a protein cage polypeptide (or scaffolding protein) useful or capable of forming a hollow tetrahedral pyramid structure, and a “self-assembling protein nanoparticle decorated with antibodies” (SAPNA) which is a chimeric protein assembly comprising: (a) one or more antibodies and (b) the protein cage polypeptide that provides a scaffold upon which to array the antibodies. In some embodiments, the antibody is capable of binding specifically to a pathogenic biological agent, or part thereof. |
| FILED | Monday, April 27, 2020 |
| APPL NO | 17/606391 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/569 (20130101) Original (OR) Class G01N 33/6854 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220197097 | Milliron et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Delia Milliron (Austin, Texas); Jongwook Kim (Austin, Texas) |
| ABSTRACT | Disclosed herein are electrochromic electrodes. The electrochromic electrodes can comprise a conducting layer; an electrochromic layer; and a conformal hole blocking layer; wherein the electrochromic layer is disposed between the conducting layer and the hole blocking layer such that the electrochromic layer is in electrical contact with the conducting layer and the hole blocking layer. The electrochromic electrodes disclosed herein can exhibit improved properties compared to an electrode comprising the same conducting layer and electrochromic layer but without the conformal hole blocking layer. For example, the electrochromic electrodes can have a reduced photochromic effect as compared to an electrode comprising the same conducting layer and electrochromic layer but without the conformal hole blocking layer. Methods of making and methods of use of the electrochromic electrodes are also discussed. |
| FILED | Thursday, March 10, 2022 |
| APPL NO | 17/691174 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/155 (20130101) Original (OR) Class G02F 1/1524 (20190101) G02F 1/1533 (20130101) G02F 2001/1555 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220198649 | Knight et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of South Caroline (Columbia, South Carolina) |
| ASSIGNEE(S) | University of South Caroline (Columbia, South Carolina) |
| INVENTOR(S) | Travis Knight (Blythewood, South Carolina); Sobhan Patnaik (Columbia, South Carolina); Theodore Besmann (Oak Ridge, Tennessee); Elwyn Roberts (Lugoff, South Carolina) |
| ABSTRACT | Described herein are systems and methods for imaging the top surface of a fuel pellet to observe the formation of radial cracks employing resistive heating to volumetrically heat the fuel pellet, but instead of passing the current axially through the pellet, electrodes were placed on the sides of a single pellet to pass the current transversely across the pellet allowing for an unobstructed view of the top surface of the pellet. |
| FILED | Thursday, October 21, 2021 |
| APPL NO | 17/506928 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/8803 (20130101) Image Data Processing or Generation, in General G06T 7/0006 (20130101) Original (OR) Class G06T 2207/30132 (20130101) Nuclear Reactors G21C 3/623 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220198896 | Candy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Christopher Roland Candy (San Ramon, California); Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Vincent Candy (Danville, California); Karl Albert Fisher (Brentwood, Canada); Christopher Roland Candy (San Ramon, California) |
| ABSTRACT | An event detection unit (EDU) for detecting an explosive event is provided. The EDU includes different types of sensors for measuring characteristics of an explosive event. The EDU includes an event notification component. The EDU also includes a processor that receives a measurement from the sensors and generates a combined non-event probability and a combined event probability based on that measurement that indicates a likelihood that an explosive event has not occurred or has occurred. The processor determines whether an explosive event has occurred based on the non-event probabilities and event probabilities. When an explosive event has been determined to occur, the processor directs the event notification component to output a notification that an explosive event has occurred. |
| FILED | Wednesday, December 23, 2020 |
| APPL NO | 17/132465 |
| CURRENT CPC | Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 3/10 (20130101) G08B 5/36 (20130101) G08B 17/08 (20130101) Original (OR) Class G08B 29/185 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220199276 | Bernstein et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lee Bernstein (Berkeley, California); Jon Batchelder (Richmond, California); Jonathan T. Morrell (Albany, California); Andrew Voyles (Berkeley, California) |
| ABSTRACT | This disclosure provides systems, methods, and apparatus related to the production of actinium-225. In one aspect, a target is irradiated with a beam of deuterons to generate a beam of neutrons. A radium-226 target is irradiated with the beam of neutrons to generate radium-225. |
| FILED | Monday, April 06, 2020 |
| APPL NO | 17/602056 |
| CURRENT CPC | Conversion of Chemical Elements; Radioactive Sources G21G 1/001 (20130101) G21G 1/06 (20130101) Original (OR) Class G21G 1/10 (20130101) G21G 4/08 (20130101) G21G 2001/0089 (20130101) Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 6/00 (20130101) H05H 13/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220199302 | Beddingfield et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alex Leary (Cleveland, Ohio); Paul Richard Ohodnicki, JR. (Allison Park, Pennsylvania); Carnegie Mellon University (Pittsburgh, Pennsylvania); North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard Byron Beddingfield (Cary, North Carolina); Paul Richard Ohodnicki, Jr. (Allison Park, Pennsylvania); Kevin Byerly (Pittsburgh, Pennsylvania); Subhashish Bhattacharya (Raleigh, North Carolina); Michael Edward McHenry, Jr. (Pittsburgh, Pennsylvania); Alex Leary (Cleveland, Ohio) |
| ABSTRACT | A transformer includes a core formed of at least one MANC alloy. The MANC alloy has a predefined permeability. |
| FILED | Monday, April 20, 2020 |
| APPL NO | 17/604180 |
| CURRENT CPC | Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 1/14 (20130101) Original (OR) Class H01F 27/022 (20130101) H01F 27/24 (20130101) H01F 27/28 (20130101) H01F 41/0206 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220199310 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgetown University (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kai Liu (Falls Church, Virginia); Gong Chen (El Cerrito, California); Andreas Schmid (Berkeley, California) |
| ABSTRACT | Embodiments may provide a realization of strong Dzyaloshinskii-Moriya interaction (DMI) and perpendicular magnetic anisotropy (PMA) induced by chemisorbed species on a ferromagnetic layer. For example, in an embodiment, an apparatus for generating DMI may comprise a ferromagnet comprising a single-layer or multi-layers of materials made of metal, oxide or other types of magnetic films, and a substance chemisorbed on a surface of the ferromagnet to induce the DMI or the PMA at the interface between the chemisorbed species and the ferromagnet. These induced effects may be used to maniupulate spin textures such as switching of domain wall chirality and writing/deleting of magnetic skyrmions, which are relevant for spintronics and magneto-ionics as well as for gas sensing. |
| FILED | Monday, March 14, 2022 |
| APPL NO | 17/694548 |
| CURRENT CPC | Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 10/3236 (20130101) Original (OR) Class H01F 10/3281 (20130101) H01F 41/303 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220199381 | TIAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | JEFFERSON SCIENCE ASSOCIATES, LLC (Newport News, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | HUI TIAN (Yorktown, Virginia); JOHN C. MUSSON (Newport News, Virginia); MATTHEW CREED BURTON (Hanover, Maryland); ANNE-MARIE VALENTE-FELICIANO (Newport News, Virginia); LARRY PHILLIPS (Newport News, Virginia) |
| ABSTRACT | A high-power pulsed surface processing system includes insulated-gate bipolar transistors (IGBT) to replicate desirable pulse structures with high precision, at low cost, and with high reliability within a single system. The pulsed surface processing system includes a power supply, an anode and a cathode, a dual gate driver supplying power to one or more IGBT gates, and one or more capacitor banks. Pulse formation software controls the timing and duration of electrical pulses to the electrodes. A freewheeling diode protects the system from an abrupt reduction of current in the circuit. The high-power pulsed surface processing system may be used to control versatile and complex pulse structures while with precise control of instantaneous pulse powers, pulse timing, and process control. The inclusion of dual gate drivers also offers the ability for multiple pulsers to be created and “slaved” together for a wide variety of custom processes. |
| FILED | Wednesday, October 06, 2021 |
| APPL NO | 17/495702 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/35 (20130101) C23C 14/3485 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 37/3405 (20130101) H01J 37/3467 (20130101) Original (OR) Class H01J 37/3488 (20130101) H01J 2237/332 (20130101) Emergency Protective Circuit Arrangements H02H 9/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220199606 | ROGERS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois); X-CELEPRINT LIMITED (Cork, Ireland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John A. ROGERS (Wilmette, Illinois); Ralph NUZZO (Champaign, Illinois); Matthew MEITL (Durham, North Carolina); Etienne MENARD (Durham, North Carolina); Alfred BACA (Urbana, Illinois); Michael MOTALA (Champaign, Illinois); Jong-Hyun AHN (Suwon, South Korea); Sang-Il PARK (Savoy, Illinois); Chang-Jae YU (Urbana, Illinois); Heung Cho KO (Gwangju, South Korea); Mark STOYKOVICH (Dover, New Hampshire); Jongseung YOON (Urbana, Illinois) |
| ABSTRACT | Provided are optical devices and systems fabricated, at least in part, via printing-based assembly and integration of device components. In specific embodiments the present invention provides light emitting systems, light collecting systems, light sensing systems and photovoltaic systems comprising printable semiconductor elements, including large area, high performance macroelectronic devices. Optical systems of the present invention comprise semiconductor elements assembled, organized and/or integrated with other device components via printing techniques that exhibit performance characteristics and functionality comparable to single crystalline semiconductor based devices fabricated using conventional high temperature processing methods. Optical systems of the present invention have device geometries and configurations, such as form factors, component densities, and component positions, accessed by printing that provide a range of useful device functionalities. Optical systems of the present invention include devices and device arrays exhibiting a range of useful physical and mechanical properties including flexibility, shapeability, conformability and stretchablity. |
| FILED | Wednesday, March 09, 2022 |
| APPL NO | 17/690952 |
| CURRENT CPC | Processes or Apparatus Specially Adapted for the Manufacture or Treatment of Microstructural Devices or Systems B81C 2201/0185 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/00 (20130101) H01L 25/042 (20130101) H01L 25/50 (20130101) Original (OR) Class H01L 25/167 (20130101) H01L 25/0753 (20130101) H01L 27/124 (20130101) H01L 27/1214 (20130101) H01L 27/1285 (20130101) H01L 27/1292 (20130101) H01L 27/14627 (20130101) H01L 27/14636 (20130101) H01L 27/14643 (20130101) H01L 31/043 (20141201) H01L 31/167 (20130101) H01L 31/0288 (20130101) H01L 31/0525 (20130101) H01L 31/0543 (20141201) H01L 31/0547 (20141201) H01L 31/0693 (20130101) H01L 31/0725 (20130101) H01L 31/1804 (20130101) H01L 31/1824 (20130101) H01L 31/1868 (20130101) H01L 31/1876 (20130101) H01L 31/1892 (20130101) H01L 31/02005 (20130101) H01L 31/02008 (20130101) H01L 31/02168 (20130101) H01L 31/02325 (20130101) H01L 31/02327 (20130101) H01L 31/03046 (20130101) H01L 33/005 (20130101) H01L 33/06 (20130101) H01L 33/30 (20130101) H01L 33/52 (20130101) H01L 33/54 (20130101) H01L 33/56 (20130101) H01L 33/58 (20130101) H01L 33/62 (20130101) H01L 33/0093 (20200501) H01L 33/483 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/021 (20130101) H01S 5/183 (20130101) H01S 5/423 (20130101) H01S 5/02251 (20210101) H01S 5/3013 (20130101) H01S 5/34326 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220199845 | Song et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Toledo (Toledo, Ohio) |
| ASSIGNEE(S) | The University of Toledo (Toledo, Ohio) |
| INVENTOR(S) | Zhaoning Song (Toledo, Ohio); Kamala Khanal Subedi (Toledo, Ohio); Randy Ellingson (Toledo, Ohio); Yanfa Yan (Toledo, Ohio) |
| ABSTRACT | An optoelectronic device comprising two photovoltaic absorber materials of CdSeTe and perovskite and their functional component layers that are monolithically integrated into a bifacial tandem solar cell structure. |
| FILED | Thursday, November 18, 2021 |
| APPL NO | 17/529682 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/073 (20130101) Original (OR) Class H01L 31/1884 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220199932 | Kim et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jongchan Kim (Ann Arbor, Michigan); Stephen R. Forrest (Ann Arbor, Michigan) |
| ABSTRACT | An organic electronic device comprises a substrate, at least one morphological stabilizing layer positioned over the substrate, the morphological stabilizing layer comprising a material having a Tg greater than 50° C., and at least one organic layer positioned in direct contact with the morphological stabilizing layer. A method of making an organic electronic device is also disclosed. |
| FILED | Wednesday, November 17, 2021 |
| APPL NO | 17/528821 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/56 (20130101) H01L 51/0562 (20130101) H01L 51/5008 (20130101) Original (OR) Class H01L 51/5012 (20130101) H01L 2251/556 (20130101) H01L 2251/558 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220199962 | Oakes et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PPG Industries Ohio, Inc. (Cleveland, Ohio) |
| ASSIGNEE(S) | PPG Industries Ohio, Inc. (Cleveland, Ohio) |
| INVENTOR(S) | Landon J. Oakes (Cambridge, Massachusetts); Stuart D. Hellring (Pittsburgh, Pennsylvania); Haley L. Orler (Bridgeville, Pennsylvania) |
| ABSTRACT | The present invention is directed towards an electrodepositable coating composition comprising an electrochemically active material comprising a protective coating; an electrodepositable binder; and an aqueous medium. Also disclosed herein is a method of coating a substrate, as well as coated substrates and electrical storage devices. |
| FILED | Tuesday, February 25, 2020 |
| APPL NO | 17/605260 |
| CURRENT CPC | Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/4407 (20130101) C09D 127/12 (20130101) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 4/008 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/131 (20130101) H01M 4/0404 (20130101) Original (OR) Class H01M 4/623 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220199971 | LI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| INVENTOR(S) | Guodong LI (Stanford, California); Wei CHEN (Stanford, California); Yi CUI (Stanford, California) |
| ABSTRACT | This disclosure provides novel batteries, e.g., redox flow batteries, and methods of making and operating batteries. Certain embodiments include redox flow battery comprising: a housing; a first electrode disposed in the housing; a second electrode disposed in the housing and facing the first electrode, the first electrode is spaced from the second electrode by a gap without an intervening ion selective membrane; and a fluid conveyance mechanism connected to the housing and configured to convey an electrolyte across the gap between the first electrode and the second electrode. |
| FILED | Tuesday, April 14, 2020 |
| APPL NO | 17/604343 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/244 (20130101) Original (OR) Class H01M 4/625 (20130101) H01M 10/36 (20130101) H01M 2300/0005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220199976 | YUSHIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sila Nanotechnologies Inc. (Alameda, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gleb YUSHIN (Atlanta, Georgia); Bogdan ZDYRKO (Atlanta, Georgia); Addison SHELTON (Atlanta, Georgia); Eugene BERDICHEVSKY (Alameda, California); Igor LUZINOV (Clemson, South Carolina); Alexander JACOBS (Oakland, California); Eerik HANTSOO (Oakland, California); George GOMES (Alameda, California) |
| ABSTRACT | A battery electrode composition is provided comprising composite particles, with each composite particle comprising active material and a scaffolding matrix. The active material is provided to store and release ions during battery operation. For certain active materials of interest, the storing and releasing of the ions causes a substantial change in volume of the active material. The scaffolding matrix is provided as a porous, electrically-conductive scaffolding matrix within which the active material is disposed. In this way, the scaffolding matrix structurally supports the active material, electrically interconnects the active material, and accommodates the changes in volume of the active material. |
| FILED | Thursday, March 10, 2022 |
| APPL NO | 17/691997 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/13 (20130101) H01M 4/38 (20130101) H01M 4/139 (20130101) H01M 4/364 (20130101) Original (OR) Class H01M 4/366 (20130101) H01M 4/0402 (20130101) H01M 4/624 (20130101) H01M 4/625 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220199991 | Huang |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ge Solartech, LLC (Troy, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Baoquan Huang (Troy, Michigan) |
| ABSTRACT | The present disclosure provides methods for producing cathode materials for lithium ion batteries. Cathode materials that contain manganese are emphasized. Representative materials include LixNi1−y−zMnyCozO2 (NMC) (where x is in the range from 0.80 to 1.3, y is in the range from 0.01 to 0.5, and z is in the range from 0.01 to 0.5), LixMn2O4(LM), and LixNi1−yMnyO2 (LMN) (where x is in the range from 0.8 to 1.3 and y is in the range from 0.0 to 0.8). The process includes reactions of carboxylate precursors of nickel, manganese, and/or cobalt and lithiation with a lithium precursor. The carboxylate precursors are made from reactions of pure metals or metal compounds with carboxylic acids. The manganese precursor contains bivalent manganese and the process controls the oxidation state of manganese to avoid formation of higher oxidation states of manganese. |
| FILED | Saturday, March 12, 2022 |
| APPL NO | 17/693330 |
| CURRENT CPC | Compounds of Alkali Metals, i.e Lithium, Sodium, Potassium, Rubidium, Caesium, or Francium C01D 15/02 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/485 (20130101) H01M 4/505 (20130101) Original (OR) Class H01M 4/525 (20130101) H01M 10/0525 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220200042 | Ignacio de Leon et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Patricia Anne Ignacio de Leon (Westmont, Illinois); John N. Hryn (Hawthorn Woods, Illinois); Li Tang (Bolingbrook, Illinois); Edward F. Barry (Chicago, Illinois); Daniel Yoav Arenas (Chicago, Illinois) |
| ABSTRACT | A process and system for creating a lithium ion anolyte from lithium alloys. Metal and lithium alloys are processed to remove the metal with lithium from the alloy remaining. A lithium ion anolyte formed may be used in a process to form lithium metal. Alternatively, a process and system for recovering lithium from sources such as lithium alloys and lithium metal oxides and other feedstock such as recycled batteries into a thin lithium metal film via electrodeposition in an organic electrolyte contacting both anode (holder for lithium source) and cathode (substrate for lithium deposition) in a single-compartment electrolysis cell. |
| FILED | Wednesday, March 09, 2022 |
| APPL NO | 17/690835 |
| CURRENT CPC | Production and Refining of Metals; Pretreatment of Raw Materials C22B 26/12 (20130101) Processes for the Electrolytic Production, Recovery or Refining of Metals; Apparatus Therefor C25C 1/02 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/052 (20130101) H01M 10/0561 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220200073 | Belharouak et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ilias Belharouak (Oak Ridge, Tennessee); Yaocai Bai (Oak Ridge, Tennessee); Rachid Essehli (Oak Ridge, Tennessee) |
| ABSTRACT | A method for recycling lithium-ion battery materials is provided. The method includes isolating a composite electrode that includes an electrode material adhered to a current collector. The isolated composite electrode is combined with a citrate-based solvent to form a mixture. The electrode material is delaminated from the current collector in the mixture to give a free electrode material and a free current collector. Each of the free electrode material and the free current collector is recovered from the mixture. The free electrode material may be reused to prepare another composite electrode, as well as a lithium-ion battery comprising the same, which are also disclosed. |
| FILED | Wednesday, December 15, 2021 |
| APPL NO | 17/551395 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/48 (20130101) H01M 4/623 (20130101) H01M 4/661 (20130101) H01M 10/54 (20130101) Original (OR) Class H01M 10/0525 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220200074 | Belharouak et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ilias Belharouak (Oak Ridge, Tennessee); Yaocai Bai (Oak Ridge, Tennessee); Rachid Essehli (Oak Ridge, Tennessee) |
| ABSTRACT | A method for recycling lithium-ion battery materials is provided. The method includes isolating a composite electrode comprising an electrode material adhered to a current collector with a polyvinylidene difluoride (PVDF) binder. The composite electrode is combined with triethyl phosphate (TEP) as a solvent to form a mixture. The electrode material is delaminated from the current collector in the mixture to give a free electrode material and a free current collector. Each of the free electrode material and the free current collector is recovered from the mixture. The free electrode material may be reused to prepare another composite electrode, as well as a lithium-ion battery comprising the same, which are also disclosed. |
| FILED | Wednesday, December 15, 2021 |
| APPL NO | 17/551636 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/54 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220200291 | Guo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Caterpillar Inc. (Peoria, Illinois) |
| ASSIGNEE(S) | Caterpillar Inc. (Peoria, Illinois) |
| INVENTOR(S) | Fang Guo (Dunlap, Illinois); Jay R. Steffen (Washington, Illinois); Chad Palmer Koci (Washington, Illinois); Richard W. Kruiswyk (Dunlap, Illinois) |
| ABSTRACT | Controlling a hybrid power system includes calculating a power system state vector based on energy demand and a stored data array including a matrix defined by a power system hardware configuration. The control further includes producing a power request based on the power system state vector, and varying a flow of energy amongst energy devices using drive linkages in the hybrid power system based on the power request. Related apparatus, control logic and controller structure is disclosed. |
| FILED | Friday, December 18, 2020 |
| APPL NO | 17/127547 |
| CURRENT CPC | Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/30 (20130101) H02J 3/46 (20130101) Original (OR) Class H02J 3/381 (20130101) H02J 2203/20 (20200101) H02J 2300/10 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220200332 | Piesciorovsky et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Emilio C. Piesciorovsky (Oak Ridge, Tennessee); Travis M. Smith (Oak Ridge, Tennessee); Michael W. Marshall (Oak Ridge, Tennessee); Srijib K. Mukherjee (Oak Ridge, Tennessee) |
| ABSTRACT | A system and method for identifying pinout information for an IED and operable to test the IED in accordance with a power system. The pinout information for many IEDs is conventionally lacking, leading to conventional testing systems that utilize amplifiers in order to generate the actual current and voltage levels of a power system for simulating the power system in conjunction with one or more IEDs. A system and method are provided to identify pinouts of an IED that can be utilized for simulating the power system with an IED without the need to generate actual current and voltage levels of the power system. |
| FILED | Monday, December 13, 2021 |
| APPL NO | 17/548744 |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/042 (20130101) G05B 2219/2639 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 13/00001 (20200101) H02J 13/00002 (20200101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220200526 | Fenning et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Fenning (Solana Beach, California); Rishi Kumar (San Diego, California); Guillaume von Gastrow (La Jolla, California) |
| ABSTRACT | A method for moisture testing of a fully assembled photovoltaic (PV) module. An assembled PV module is probed with short wave IR probe energy in the range of 1700-2000 nm. Energy reflected from the assembled PV module is collected and directed to a sensor. Noise is removed from a signal of the sensor with reference to the probe energy. Absorption is of the probe energy is determined. The absorption is correlated to moisture in the PV module. A preferred system that carries out the method provides a signal-to-noise ratio (as defined by standard deviation/mean of measured reflectance) of at least 3800. |
| FILED | Tuesday, April 28, 2020 |
| APPL NO | 17/604921 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/3554 (20130101) G01N 2201/065 (20130101) Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 50/15 (20141201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220200900 | Roweth |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hewlett Packard Enterprise Development LP (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Duncan Roweth (Bristol Avon, United Kingdom) |
| ABSTRACT | System and methods are described for providing adaptive routing in the presence of persistent flows. Switches in a fabric have the capability to establish flow channels. Switches can adaptively route flows, while monitoring transmission characteristics of the flows channels to identify whether any flows are experiencing congestion towards a destination. In response to detecting congestion, it can be further determined whether the flow is related to a source of congestion, or alternative the flow is a victim of congestion. Flows that are a source of congestion have their routing constrained to prevent congestion from propagating. For example, new packets of a flow that is a source of congestion may be forced to only take the path of the data transmission that detected said congestion (preventing congestion from spreading). Alternatively, victims of congestion do not have their routing constrained, and packets can take any path as permitted by adaptive routing. |
| FILED | Monday, March 23, 2020 |
| APPL NO | 17/594721 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 45/021 (20130101) H04L 45/22 (20130101) H04L 45/28 (20130101) H04L 45/38 (20130101) Original (OR) Class H04L 47/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20220192919 | Wilson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert H. Wilson (Irvine, California); Christian Crouzet (Irvine, California); Yama Akbari (Irvine, California); Bernard Choi (Irvine, California); Bruce J. Tromberg (Irvine, California) |
| ABSTRACT | A multimodal optical imaging platform is used to obtain cerebral perfusion-metabolism mismatch metrics for rapid assessment of acute brain injury, ongoing (real-time) feedback to optimize cardiopulmonary resuscitation to improve neurological outcome, and rapid prognosis of recovery. Light of several wavelengths and types is delivered to the tissue, which is then absorbed and scattered by tissue components such as blood and cellular components. Some of this light scatters back to the surface, where it is captured by a detector. The resulting data are processed to obtain blood flow and oxygenation parameters, as well as tissue scattering. These parameters are then combined to calculate metabolism and flow-metabolism coupling/decoupling metrics, which are used to determine ischemic damage, ongoing need for optimal blood flow and oxygenation, and to predict cerebral recovery in patients with acute brain injury during and immediately after cardiac arrest, stroke, traumatic brain injury, etc. |
| FILED | Wednesday, March 09, 2022 |
| APPL NO | 17/690866 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0205 (20130101) A61B 5/0261 (20130101) A61B 5/14552 (20130101) A61B 5/14553 (20130101) Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 31/005 (20130101) Original (OR) Class A61H 2230/207 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/39044 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220192986 | Huebsch et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Nathaniel D. Huebsch (Colma, California); Christopher M. Madl (Vestal, New York); Kangwon Lee (Lexington, Massachusetts); Maria M. Xu (Morgantown, West Virginia); David J. Mooney (Sudbury, Massachusetts) |
| ABSTRACT | The invention provides compositions and methods to form pores in situ within hydrogels following hydrogel injection. Pores formed in situ via degradation of sacrificial porogens within the surrounding hydrogel facilitate recruitment or release of cells. Disclosed herein is a material that is not initially porous, but which becomes macroporous over time. |
| FILED | Tuesday, November 09, 2021 |
| APPL NO | 17/522297 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1652 (20130101) Original (OR) Class Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/20 (20130101) A61L 27/26 (20130101) A61L 27/38 (20130101) A61L 27/48 (20130101) A61L 27/52 (20130101) A61L 27/54 (20130101) A61L 27/56 (20130101) A61L 27/58 (20130101) A61L 2300/414 (20130101) A61L 2400/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193457 | Konofagou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (NEW YORK, New York) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (NEW YORK, New York) |
| INVENTOR(S) | Elisa E. Konofagou (New York, New York); Fabrice Marquet (New York, New York); Yao-Sheng Tung (New York, New York) |
| ABSTRACT | Systems and methods for cavitation-guided opening of a targeted region of tissue within a primate skull are provided. In one example, a method includes delivering one or more microbubbles to proximate the targeted region, applying an ultrasound beam, using a transducer, through the skull of the primate to the targeted region to open the tissue, transcranially acquiring acoustic emissions produced from an interaction between the one or more microbubbles and the tissue, and determining a cavitation spectrum from the acquired acoustic emissions. |
| FILED | Wednesday, March 09, 2022 |
| APPL NO | 17/690523 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/481 (20130101) A61B 8/0808 (20130101) A61B 17/2258 (20130101) A61B 2017/00106 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 7/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193775 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lianyi Chen (Rolla, Missouri); Qilin Guo (Madison, Wisconsin) |
| ABSTRACT | Aspects of the disclosure are directed to forming a three-dimensional (3D) structure by depositing an alloy composition on a target, and solidifying portions of the alloy composition to form the 3D structure. The solidifying includes producing a martensitic structure by destabilizing a ferrite phase of the alloy composition while solidifying the alloy composition. |
| FILED | Tuesday, December 22, 2020 |
| APPL NO | 17/130656 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/28 (20210101) B22F 10/50 (20210101) Original (OR) Class B22F 2301/35 (20130101) Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/342 (20151001) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) Alloys C22C 38/002 (20130101) C22C 38/02 (20130101) C22C 38/04 (20130101) C22C 38/42 (20130101) C22C 38/48 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193887 | Li et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jared Li (Atlanta, Georgia); Bharat Kanwar (Atlanta, Georgia); Theodore Johnson (Atlanta, Georgia); Jonathan Meditz (Atlanta, Georgia); Avery Yang (Atlanta, Georgia); Noel Csomay-Shanklin (Atlanta, Georgia); Joshua Bishop (Atlanta, Georgia); Dean Molinaro (Atlanta, Georgia); Aaron Young (Atlanta, Georgia) |
| ABSTRACT | An exemplary embodiment of the present invention provides an exosuit support system, comprising first and second orthotic interfaces, first and second members, and first and second actuators. The first and second orthotic interfaces can be configured to attach to left and right legs of a user, respectively. The first member can comprise a first end connected to the first orthotic interface and a second end connected to a portion of the system configured to be positioned proximate a right shoulder of the user. The second member can comprise a first end connected to the second orthotic interface and a second end connected to a portion of the system configured to be positioned proximate a left shoulder of the user. The first actuator can be configured to apply a first tension to the first member. The second actuator can be configured to apply a second tension to the second member. |
| FILED | Friday, April 17, 2020 |
| APPL NO | 17/604271 |
| CURRENT CPC | Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 1/0244 (20130101) A61H 1/0281 (20130101) A61H 2201/165 (20130101) A61H 2201/1215 (20130101) A61H 2201/5007 (20130101) A61H 2201/5061 (20130101) A61H 2201/5084 (20130101) Manipulators; Chambers Provided With Manipulation Devices B25J 9/0006 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193891 | KARYDIS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Konstantinos KARYDIS (Riverside, California); Zhichao LIU (Riverside, California) |
| ABSTRACT | This disclosure relates to apparatus a multi-legged robot including at least one pair of actuators. Each actuator includes a pliable body. The pliable body includes a first portion having a first chamber, a second portion having a second chamber, where the second portion coupled to a distal end of the first portion. The pliable body includes a first inlet coupled to the first chamber, where the first portion is configured to bend upon receiving a first fluid via the first inlet and a second inlet coupled to the second chamber, where the second portion is configured to extend upon receiving a second fluid via the second inlet. The multi-legged robot includes a frame coupled to a proximate end of the first portion of each actuator. |
| FILED | Wednesday, December 22, 2021 |
| APPL NO | 17/560075 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/144 (20130101) Original (OR) Class B25J 18/06 (20130101) Motor Vehicles; Trailers B62D 57/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220194858 | Adamson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Connecticut (Farmington, Connecticut) |
| ASSIGNEE(S) | University of Connecticut (Farmington, Connecticut) |
| INVENTOR(S) | Douglas H. Adamson (Mansfield Center, Connecticut); Garrett Kraft (Cottonwood Heights, Utah) |
| ABSTRACT | Porous, electrically conductive ceramic foams incorporating continuous self-assembled graphene networks are described. The disclosed approach uses interfacial trapping to spontaneously exfoliate and assemble pristine graphite, not graphite oxide, in a ceramic sol-gel. The composite foams display electrical conductivity and joule heating, with anticipated applications as, for example, catalyst supports, thermoelectrics, and porous electrodes. |
| FILED | Wednesday, December 15, 2021 |
| APPL NO | 17/552178 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/19 (20170801) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/14 (20130101) Original (OR) Class C04B 41/5001 (20130101) C04B 2235/5292 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/625 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195392 | ROWAT et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Amy ROWAT (Los Angeles, California); Nora Stephanie KAWECKI (Los Angeles, California); Siobhan Ariel BROOK (Los Angeles, California); Sam NORRIS (Los Angeles, California) |
| ABSTRACT | Embodiments of the invention describe a cultured meat or food product with more desirable flavor and texture, as well as methods and compositions for producing the same. Certain embodiments are directed to methods of producing a stiffer, structured surfaces or scaffolds that mimic the extracellular matrix (ECM) and support the growth of myotubes that are interspersed with a scaffold component supporting fat cells (adipocytes) in vitro. |
| FILED | Thursday, April 23, 2020 |
| APPL NO | 17/604840 |
| CURRENT CPC | Protein Compositions for Foodstuffs; Working-up Proteins for Foodstuffs; Phosphatide Compositions for Foodstuffs A23J 3/227 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0658 (20130101) Original (OR) Class C12N 2513/00 (20130101) C12N 2531/00 (20130101) C12N 2533/74 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20220195421 — BISTABLE POLYNUCLEOTIDE DEVICES FOR THE SENSING AND QUANTIFICATION OF MOLECULAR EVENTS
| US 20220195421 | Gopinath et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ashwin Gopinath (Pasadena, California); Paul W.K. Rothemund (Pasadena, California) |
| ABSTRACT | Bistable devices are constructed using a polynucleotide platform for the sensing of molecular events such as binding or conformational changes of target molecules. Uses include measurement of target concentration, measuring the effect of environmental condition (such as heat, light, or pH) on the target, or screening a library for molecules that bind the target or modulate its biological function. Devices comprise three regions: a top lid, bottom lid, and flexible linker or hinge between them. A device has an open configuration in which the top and bottom lid are separated, and a closed configuration they are bound close together. Binding domains or variations of the target molecule are fixed to a device so that when the molecular event occurs, the device switches from open to closed, or vice versa, which generates a signal. Devices carry DNA tags to enable separation of open and closed devices, as well as barcoding for multiplexed detection. |
| FILED | Friday, December 03, 2021 |
| APPL NO | 17/542224 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 2525/30 (20130101) C12Q 2525/197 (20130101) C12Q 2525/205 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/573 (20130101) G01N 33/5308 (20130101) G01N 2333/705 (20130101) G01N 2333/912 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195559 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Nien-Hwa Linda Wang (West Lafayette, Indiana); Hoon Choi (Miami, Florida); David Harvey (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nien-Hwa Linda Wang (West Lafayette, Indiana); Hoon Choi (Miami, Florida); David Harvey (West Lafayette, Indiana) |
| ABSTRACT | A process disclosed herein is related to the isolation and purification of substantially pure chemicals, including silica gel, sodium silicate, aluminum silicate, iron oxide, and rare earth elements (or rare earth metals, REEs), from massive industrial waste coal ash. In one embodiment, the process includes a plurality of caustic extractions of coal ash at an elevated temperature, followed by an acidic treatment to dissolve aluminum silicate and REEs. The dissolved aluminum silicate is precipitated out by pH adjustment as a solid product while REEs remain in the solution. REEs are captured and enriched using an ion exchange column. Alternatively, the solution containing aluminum silicate and REEs is heated to produce silica gel, which is easily separated from the enriched REEs solution. REEs are then isolated and purified from the enriched solution to afford substantially pure individual REE by a ligand-assisted chromatography. Additionally, a simplified process using one caustic extraction and one acidic extraction with an ion exchange process was also investigated and optimized to afford a comparable efficiency. |
| FILED | Monday, November 29, 2021 |
| APPL NO | 17/536403 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 33/14 (20130101) C01B 33/26 (20130101) C01B 33/32 (20130101) Compounds of Alkali Metals, i.e Lithium, Sodium, Potassium, Rubidium, Caesium, or Francium C01D 13/00 (20130101) Compounds of the Metals Beryllium, Magnesium, Aluminium, Calcium, Strontium, Barium, Radium, Thorium, or of the Rare-earth Metals C01F 7/0693 (20130101) C01F 11/02 (20130101) C01F 11/24 (20130101) C01F 17/271 (20200101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 49/02 (20130101) C01G 49/06 (20130101) C01G 49/10 (20130101) Production and Refining of Metals; Pretreatment of Raw Materials C22B 3/08 (20130101) C22B 3/10 (20130101) C22B 3/42 (20130101) C22B 3/44 (20130101) C22B 3/065 (20130101) C22B 7/02 (20130101) C22B 7/007 (20130101) Original (OR) Class C22B 21/0023 (20130101) C22B 59/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220196832 | Gollakota et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Shyamnath Gollakota (Seattle, Washington); Anran Wang (Seattle, Washington); Jacob Sunshine (Seattle, Washington) |
| ABSTRACT | Embodiments of the present disclosure provide systems and methods directed to contactless motion tracking. In operation, a speaker may provide an acoustic signal to, for example, a subject. A microphone array may receive a reflected acoustic signal, where the received reflected signal is responsive to the acoustic signal reflecting off the subject. A computing device may extraction motion data of the subject based on the received reflected acoustic signal. Various motion data extraction methods are described herein. The motion data may include respiration motion, coarse movement motion, respiration rate, and the like. Using the extracted motion data, the processor may identify at least one health condition and/or sleep anomaly corresponding to the subject. In some examples, beamforming is implemented to aid in contactless motion tracking. |
| FILED | Thursday, April 16, 2020 |
| APPL NO | 17/604311 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/113 (20130101) A61B 5/0205 (20130101) A61B 5/0816 (20130101) A61B 5/1113 (20130101) A61B 5/4806 (20130101) A61B 7/003 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 15/66 (20130101) G01S 15/88 (20130101) G01S 15/586 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220197276 | Chowdhary et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (URBANA, Illinois) |
| INVENTOR(S) | Girish Chowdhary (Champaign, Illinois); Chinmay P. Soman (Urbana, Illinois); Beau David Barber (Ogden, Illinois) |
| ABSTRACT | The present disclosure provides a system for monitoring unstructured environments. A predetermined path can be determined according to an assignment of geolocations to one or more agronomically anomalous target areas, where the one or more agronomically anomalous target areas are determined according to an analysis of a plurality of first images that automatically identifies a target area that deviates from a determination of an average of the plurality of first images that represents an anomalous place within a predetermined area, where the plurality of first images of the predetermined area are captured by a camera during a flight over the predetermined area. A camera of an unmanned vehicle can capture at least one second image of the one or more agronomically anomalous target areas as the unmanned vehicle travels along the predetermined path. |
| FILED | Tuesday, November 09, 2021 |
| APPL NO | 17/522699 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 39/024 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/0038 (20130101) Original (OR) Class Electric Digital Data Processing G06F 16/29 (20190101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6263 (20130101) Image or Video Recognition or Understanding G06V 20/188 (20220101) Traffic Control Systems G08G 5/0039 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220197811 | Ganguly et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania) |
| INVENTOR(S) | Debashis Ganguly (Pittsburgh, Pennsylvania); Rami G. Melhem (Pittsburgh, Pennsylvania); Ziyu Zhang (Pittsburgh, Pennsylvania); Jun Yang (Pittsburgh, Pennsylvania) |
| ABSTRACT | A data management method wherein a working set is distributed between near and far memories includes migrating first data from the far to the near memory according to a prefetcher algorithm. The first data (a subset of the working set) is maintained in the near memory in data structures according to predetermined semantics of the prefetcher that dictate that certain of the first data is prefetched when a first function evaluates as true. The method further includes detecting that the near memory has reached capacity, and in response, adaptively migrating a portion of the first data out of the near and into the far memory according to an eviction algorithm that is based on the set of prefetcher semantics such that certain of the portion of the first data is evicted when a second function evaluates as true, wherein the second function equals the inverse of the first function. |
| FILED | Friday, April 17, 2020 |
| APPL NO | 17/594362 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/3009 (20130101) G06F 12/0862 (20130101) Original (OR) Class G06F 12/0891 (20130101) G06F 13/1668 (20130101) G06F 13/4221 (20130101) G06F 2212/2542 (20130101) G06F 2212/6028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220198308 | KUMAR et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mrinal KUMAR (Columbus, Ohio); Chao YANG (Columbus, Ohio) |
| ABSTRACT | Forecasting is built around an adaptive particle approach, which may be classified under the broad umbrella of Monte Carlo methods. Performance can be self-monitoring, and an ensemble can be adaptively modified to maintain performance within prescribed bounds. If underperforming, additional particles can be added until performance is again within the prescribed bounds. If overperforming, particles can optionally be removed until performance is within the prescribed bounds. |
| FILED | Thursday, May 21, 2020 |
| APPL NO | 17/605840 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 7/005 (20130101) Original (OR) Class G06N 20/20 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220198711 | Mayer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Drexel University (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | Drexel University (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Owen Mayer (Philadelphia, Pennsylvania); Matthew C. Stamm (Philadelphia, Pennsylvania) |
| ABSTRACT | Information about an image's source camera model is important knowledge in many forensic investigations. In this paper the system(s) pro-pose a system that compares two image patches to determine if they were captured by the same camera model. To do this, the system(s) first train a CNN based feature extractor to output generic, high level features which encode information about the source camera model of an image patch. Then, the system(s) learn a similarity measure that maps pairs of these features to a score indicating whether the two image patches were captured by the same or different camera models. The system(s) show that the proposed system accurately determines if two patches were captured by the same or different camera models, even when the camera models are unknown to the investigator. The system(s) also demonstrate the utility of this approach for image splicing detection and localization. |
| FILED | Monday, March 30, 2020 |
| APPL NO | 17/599872 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/80 (20170101) Original (OR) Class G06T 2207/10024 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220198941 | Tao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qiuyang Tao (Atlanta, Georgia); Tony X. Lin (Atlanta, Georgia); Junkai Wang (Atlanta, Georgia); Zheyuan Xu (Atlanta, Georgia); Fumin Zhang (Atlanta, Georgia) |
| ABSTRACT | A robotic system includes a robot, a motion capture system and a ground station. The robot includes motors, a transceiver, an actuation circuit that receives an actuation command data packet from the transceiver and controls actuation of the motors. The motion capture system tracks a position and attitude of the robot and generates position and attitude data. The ground station is in wireless data communication with the transceiver and is in data communication with the motion capture system. The ground station receives the position and attitude data from the motion capture system; calculates a desired actuation for the robot; generates actuation command data packets for effecting the desired actuation. The actuation command data packets are transmitted wirelessly to the robot transceiver. The robot actuates the plurality motors upon receiving the actuation command data packet. |
| FILED | Thursday, November 11, 2021 |
| APPL NO | 17/524182 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 39/024 (20130101) B64C 2201/108 (20130101) B64C 2201/143 (20130101) Image Data Processing or Generation, in General G06T 7/70 (20170101) G06T 7/292 (20170101) G06T 2207/30252 (20130101) Traffic Control Systems G08G 5/0013 (20130101) Original (OR) Class G08G 5/0043 (20130101) G08G 5/0069 (20130101) Wireless Communication Networks H04W 4/33 (20180201) H04W 4/40 (20180201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220199151 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Muqing Liu (Minneapolis, Minnesota); Chen Zhou (Minneapolis, Minnesota); Keshab K. Parhi (Minneapolis, Minnesota); Hyung-il Kim (Minneapolis, Minnesota) |
| ABSTRACT | A method includes setting an output of each memory cell in an array of memory cells to a same first value, decreasing power to the array of memory cells and then increasing power to the array of memory cells. Memory cells in the array of memory cells with outputs that switched to a second value different from the first value are then identified in response to decreasing and then increasing the power. A set of memory cells is then selected from the identified memory cells to use in hardware security. |
| FILED | Thursday, March 10, 2022 |
| APPL NO | 17/691618 |
| CURRENT CPC | Electric Digital Data Processing G06F 12/14 (20130101) G06F 21/44 (20130101) G06F 21/45 (20130101) G06F 21/73 (20130101) Static Stores G11C 11/417 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 9/3278 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220199310 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgetown University (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kai Liu (Falls Church, Virginia); Gong Chen (El Cerrito, California); Andreas Schmid (Berkeley, California) |
| ABSTRACT | Embodiments may provide a realization of strong Dzyaloshinskii-Moriya interaction (DMI) and perpendicular magnetic anisotropy (PMA) induced by chemisorbed species on a ferromagnetic layer. For example, in an embodiment, an apparatus for generating DMI may comprise a ferromagnet comprising a single-layer or multi-layers of materials made of metal, oxide or other types of magnetic films, and a substance chemisorbed on a surface of the ferromagnet to induce the DMI or the PMA at the interface between the chemisorbed species and the ferromagnet. These induced effects may be used to maniupulate spin textures such as switching of domain wall chirality and writing/deleting of magnetic skyrmions, which are relevant for spintronics and magneto-ionics as well as for gas sensing. |
| FILED | Monday, March 14, 2022 |
| APPL NO | 17/694548 |
| CURRENT CPC | Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 10/3236 (20130101) Original (OR) Class H01F 10/3281 (20130101) H01F 41/303 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220199323 | Oh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Seongshik Oh (Marlboro, New Jersey); Gaurab Rimal (Highland Park, New Jersey) |
| ABSTRACT | A method for inducing tunable ferromagnetism with hydrogen annealing in delafossite films includes obtaining a PdCoO2 thin film, positioning the PdCoO2 thin film on a substrate, annealing the PdCoO2 thin film by hydrogenation, and cooling the PdCoO2 thin film to approximately room temperature. |
| FILED | Tuesday, December 21, 2021 |
| APPL NO | 17/558057 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/56 (20130101) C23C 16/406 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 10/12 (20130101) H01F 41/22 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220199384 | Cooks et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Graham Cooks (West Lafayette, Indiana); Guangtao Li (Carmel, Indiana); Guangming Huang (West Lafayette, Indiana); Jason Duncan (Dayton, Indiana); Xin Li (West Lafayette, Indiana); Ewa Sokol (West Lafayette, Indiana); Xin Yan (West Lafayette, Indiana) |
| ABSTRACT | The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface. |
| FILED | Thursday, July 16, 2020 |
| APPL NO | 16/930388 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/62 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/0018 (20130101) H01J 49/045 (20130101) Original (OR) Class H01J 49/0445 (20130101) Technical Subjects Covered by Former US Classification Y10T 436/24 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220199966 | CHEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Zheng CHEN (San Diego, California); Yang SHI (San Diego, California) |
| ABSTRACT | A method for direct recycling of degraded lithium-ion battery (LIB) cathodes includes relithiating degraded lithium nickel cobalt manganese oxide (NCM) by mixing the cathode particles with a eutectic molten-salt solution and heating the mixture at ambient pressure over a period of time, followed by a short-time thermal annealing. Combining low-temperature relithiation using the eutectic molten-salt solution with thermal annealing provides successful regeneration and full recovery of the LIB to its original storage capacity, cycling stability and rate capability to the levels of the pristine materials. The method is useful to recycle and remanufacture degraded cathode materials for LIB or sodium-ion batteries. |
| FILED | Wednesday, March 11, 2020 |
| APPL NO | 17/438397 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/0471 (20130101) Original (OR) Class H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 10/54 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220201014 | Saha et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| INVENTOR(S) | Tanujay Saha (Princeton, New Jersey); Najwa Aaraj (Paris, France); Niraj K. Jha (Princeton, New Jersey) |
| ABSTRACT | According to various embodiments, a method for detecting security vulnerabilities in at least one of cyber-physical systems (CPSs) and Internet of Things (IoT) devices is disclosed. The method includes constructing an attack directed acyclic graph (DAG) from a plurality of regular expressions, where each regular expression corresponds to control-data flow for a known CPS/IoT attack. The method further includes performing a linear search on the attack DAG to determine unexploited CPS/IoT attack vectors, where a path in the attack DAG that does not represent a known CPS/IoT attack vector represents an unexploited CPS/IoT attack vector. The method also includes applying a trained machine learning module to the attack DAG to predict new CPS/IoT vulnerability exploits. The method further includes constructing a defense DAG configured to protect against the known CPS/IoT attacks, the unexploited CPS/IoT attacks, and the new CPS/IoT vulnerability exploits. |
| FILED | Tuesday, February 25, 2020 |
| APPL NO | 17/603453 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6256 (20130101) G06K 9/6269 (20130101) Computer Systems Based on Specific Computational Models G06N 7/005 (20130101) G06N 20/00 (20190101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/1416 (20130101) Original (OR) Class H04L 63/1425 (20130101) H04L 63/1458 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20220192635 | ROBLES |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States Govermment as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | GERARDO ROBLES (Los Angeles, California) |
| ABSTRACT | An assembly for receiving a transesophageal echocardiogram (TEE) probe comprising a probe shaft having a length can comprise a cover defining an opening at a proximal end and a receiving space in communication with the opening, the receiving space having a length in a longitudinal dimension that is sufficient to receive the length of the probe shaft. A gel capsule can be positioned within the receiving space of the cover. The gel capsule can define a proximal opening and an interior in communication with the proximal opening. The interior of the gel capsule can contain a quantity of gel. Within a plane that is perpendicular to the longitudinal dimension, the interior can have a cross sectional area that is sufficient to receive a distal end of the probe shaft with a clearance to permit contact between the gel within the capsule and an exterior surface of the probe shaft. |
| FILED | Friday, May 08, 2020 |
| APPL NO | 17/609044 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/12 (20130101) A61B 8/445 (20130101) Original (OR) Class A61B 8/0883 (20130101) A61B 8/4281 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193136 | CHEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); Seattle Children's Hospital DBA Seattle Children's Research Institute (Seatlle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yvonne Y. CHEN (Los Angeles, California); Eugenia ZAH (Los Angeles, California); Michael C. JENSEN (Seattle, Washington) |
| ABSTRACT | A CD19-OR-CD20 chimeric antigen receptor (CAR) protein construct is provided. Also provided are nucleic acids encoding the CD19-OR-CD20 CAR; and methods of use, e.g. in the treatment of B cell malignancies. The CD19-OR-CD20 CAR of the invention is a bispecific CAR that can trigger T-cell activation upon detection of either CD19 or CD20 (or both). It is a single molecule that confers two-input recognition capability upon human T cells engineered to stably express this CAR. |
| FILED | Wednesday, January 05, 2022 |
| APPL NO | 17/569107 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 38/00 (20130101) Peptides C07K 14/7051 (20130101) C07K 14/70521 (20130101) C07K 14/70596 (20130101) C07K 16/46 (20130101) C07K 16/2803 (20130101) C07K 16/2887 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193181 | Singh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (Charleston, South Carolina) |
| ASSIGNEE(S) | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (Charleston, South Carolina) |
| INVENTOR(S) | Inderjit Singh (Mount Pleasant, South Carolina); Avtar K. Singh (Mount Pleasant, South Carolina) |
| ABSTRACT | The present disclosure provides methods for the treatment or prevention of SARS-Cov-2 infection or disease and IL-6 mediated immune/autoimmune and cancers by the administration of GSNO or GSNO reductase inhibitor. |
| FILED | Tuesday, December 21, 2021 |
| APPL NO | 17/557628 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/198 (20130101) A61K 31/4178 (20130101) A61K 38/28 (20130101) A61K 38/063 (20130101) Original (OR) Class A61K 38/215 (20130101) A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193410 | Galor |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States Government As Represented By The Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anat Galor (Miami, Florida) |
| ABSTRACT | The disclosure relates to methods of treating or reducing ocular pain in a subject. The method includes stimulating nasal tissue in a subject in need of treatment. Optionally, the method can be performed using a stimulator probe having first and second nasal insertion prongs having respective electrodes that can be positioned adjacent to a septum of the subject. The stimulator probe can be connected to a stimulator body having a control subsystem to control an electrical stimulus to be delivered to the subject via the stimulator probe. Optionally, the subject does not have low tear volume. |
| FILED | Wednesday, April 08, 2020 |
| APPL NO | 17/602058 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/13 (20130101) A61K 38/2006 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/36021 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220194930 | SADEGHI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yale University (New Haven, Connecticut); The United States of America as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mehran SADEGHI (Easton, Connecticut); Yunpeng YE (Staten Island, New York); Hye-Yeong KIM (Hamden, Connecticut); Henry(Yiyun) HUANG (Madison, Connecticut); Jakub TOCZEK (New Haven, Connecticut) |
| ABSTRACT | The present invention provides certain compounds, or salts or solvates thereof, which can be used as matrix metalloproteinase-targeted inhibitors or imaging agents. |
| FILED | Friday, March 11, 2022 |
| APPL NO | 17/693011 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/044 (20130101) Heterocyclic Compounds C07D 273/01 (20130101) C07D 413/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195524 | Patel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTH FLORIDA (TAMPA, Florida); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (WASHINGTON, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Niketa A. Patel (Land O' Lakes, Florida); Jianfeng Cai (Tampa, Florida) |
| ABSTRACT | Described herein are assays, methods, and devices for diagnosing/prognosing Alzheimer's disease (AD) and/or a neurodegenerative disease in a subject. The assays, methods, and/or devices described herein can be configured to detect GAS5 long-coding RNAs and/or expression thereof in a sample from a subject. |
| FILED | Tuesday, January 04, 2022 |
| APPL NO | 17/568617 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/404 (20130101) A61K 45/06 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/158 (20130101) C12Q 2600/178 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20220194562 | Shmilovich et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Boeing Company (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arvin Shmilovich (Huntington Beach, California); Abdollah Khodadoust (Long Beach, California); Christopher Colletti (Urbana, Illinois) |
| ABSTRACT | Air acceleration at slot of aircraft wing. In one embodiment, a wing includes an air duct configured to transport air in a spanwise direction along a leading edge of the wing from an air supply source of the aircraft. The wing further includes a discharge duct configured to transport the air in an aft direction from the air duct to an aft end of the wing, and one or more nozzles disposed on the aft end of the wing and configured to accelerate air into a slot between the wing and a flap of the aircraft to increase lift and reduce drag for the wing. |
| FILED | Wednesday, October 20, 2021 |
| APPL NO | 17/506589 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 21/025 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220194633 | Vasconcelos da Costa et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Tennessee Research Foundation (Knoxville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jose Lino Vasconcelos da Costa (Tullahoma, Tennessee); Trevor Michael Moeller (Manchester, Tennessee); Justin Michael Jones (Cleveland, Tennessee); Brian Keith Canfield (Tullahoma, Tennessee); Alexander Yuryevich Terekhov (Hermitage, Tennessee); Joshua Harrison Howell (Franklin, Tennessee) |
| ABSTRACT | One or more electrospray emitters form an electrospray thruster, suitable for generating thrust for maneuvering and/or moving a structure to which the thruster is attached in three-dimensional space. The thruster includes a reservoir containing a fluid, preferably an ionic liquid (IL) fluid. Each electrospray emitter includes a dielectric, with channel(s) formed through a thickness thereof, and an extraction electrode, preferably an extraction grid, on an opposite side of the dielectric from the reservoir. Upon application of a sufficient electric potential differential between the extraction electrode and the fluid, the fluid flows through the channels from the reservoir, forms a Taylor cone at an outlet of each channel, and is ejected in the direction of the extraction grid to generate a thrust by the thruster for movement and/or maneuvering of the structure to which the thruster is attached. |
| FILED | Friday, December 10, 2021 |
| APPL NO | 17/548446 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/405 (20130101) Original (OR) Class Producing a Reactive Propulsive Thrust, Not Otherwise Provided for F03H 1/0037 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195222 | GLENN |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Morningbird Media Corporation (Victoria, Texas) |
| ASSIGNEE(S) | Morningbird Media Corporation (Victoria, Texas) |
| INVENTOR(S) | Chance M. GLENN (Victoria, Texas) |
| ABSTRACT | A composition, method, and system for directly printing and creating complete functional 3D electronic circuits and devices without any thermal or laser post-processing treatment, by using at least Triphenylamine (TPA) as a powder binding agent. The composition can have mechanical characteristics that allow it to be melted and extruded on a structure, and electrical properties that allow it to function as at least one of a conductor, insulator, resistor, p-type semiconductor, n-type semiconductor, or capacitor. |
| FILED | Friday, March 04, 2022 |
| APPL NO | 17/686932 |
| CURRENT CPC | Preparation or Pretreatment of the Material to be Shaped; Making Granules or Preforms; Recovery of Plastics or Other Constituents of Waste Material Containing Plastics B29B 11/10 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/118 (20170801) B29C 64/291 (20170801) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2067/046 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/02 (20130101) C09D 11/037 (20130101) C09D 11/52 (20130101) C09D 11/101 (20130101) C09D 11/102 (20130101) C09D 11/104 (20130101) Original (OR) Class C09D 11/322 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/24 (20130101) H01B 3/421 (20130101) Resistors H01C 17/0652 (20130101) H01C 17/06586 (20130101) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 4/33 (20130101) H01G 4/1218 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/02422 (20130101) H01L 21/02532 (20130101) H01L 21/02623 (20130101) H01L 21/02664 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 3/1283 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220196550 | Christensen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Lance E. Christensen (Baldwin Park, California); Kamjou Mansour (La Cañada Flintridge, California) |
| ABSTRACT | An in-situ sensor system that is configured to be placed inside of an oxygen mask for a pilot. The sensor system is readily placed in a position over the exhalation valve such that it can capture data from the exhaled air of the pilot. The sensor system has an optical sensor element that can capture data real time and feed the data to a control module that can subsequently be use to generate output data for the pilot and/or ground elements. |
| FILED | Friday, December 17, 2021 |
| APPL NO | 17/645026 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 16/0003 (20140204) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/61 (20130101) Original (OR) Class G01N 33/004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220199987 | YUSHIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sila Nanotechnologies Inc. (Alameda, California) |
| ASSIGNEE(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| INVENTOR(S) | Gleb YUSHIN (Atlanta, Georgia); Oleksandr MAGAZYNSKYY (Atlanta, Georgia); Patrick DIXON (Dunwoody, Georgia); Benjamin HERTZBERG (New York, New York) |
| ABSTRACT | Described herein are improved composite anodes and lithium-ion batteries made therefrom. Further described are methods of making and using the improved anodes and batteries. In general, the anodes include a porous composite having a plurality of agglomerated nanocomposites. At least one of the plurality of agglomerated nanocomposites is formed from a dendritic particle, which is a three-dimensional, randomly-ordered assembly of nanoparticles of an electrically conducting material and a plurality of discrete non-porous nanoparticles of a non-carbon Group 4A element or mixture thereof disposed on a surface of the dendritic particle. At least one nanocomposite of the plurality of agglomerated nanocomposites has at least a portion of its dendritic particle in electrical communication with at least a portion of a dendritic particle of an adjacent nanocomposite in the plurality of agglomerated nanocomposites. |
| FILED | Thursday, March 10, 2022 |
| APPL NO | 17/692030 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/38 (20130101) H01M 4/133 (20130101) H01M 4/134 (20130101) H01M 4/137 (20130101) H01M 4/366 (20130101) Original (OR) Class H01M 4/587 (20130101) H01M 4/602 (20130101) H01M 4/625 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20220192183 | Cope et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Accelerated Ag Technologies, LLC (Ames, Iowa) |
| ASSIGNEE(S) | Accelerated Ag Technologies, LLC (Ames, Iowa) |
| INVENTOR(S) | Jason Cope (Ankeny, Iowa); George Singletary (Ankeny, Iowa); Todd Krone (Des Moines, Iowa); Sara Katherine Etter (Bondurant, Iowa) |
| ABSTRACT | Described are methods of preserving cereal crop pollen and/or anthers. A method of the present invention includes collecting fresh pollen and/or anthers and introducing the pollen and/or anthers to field conditioning conditions which regulate pollen moisture content. The field conditioning conditions may include a an air flow at a humidity ranging from 0% to about 99% and a temperature ranging from about −10-10° C. The field conditioning conditions may further include a flow of one or more continuously refreshed, selected gases. The field conditioning conditions may dehydrate the pollen to achieve a pollen moisture content of about 15% to about 35%. |
| FILED | Friday, March 04, 2022 |
| APPL NO | 17/686939 |
| CURRENT CPC | Horticulture; Cultivation of Vegetables, Flowers, Rice, Fruit, Vines, Hops or Seaweed; Forestry; Watering A01G 7/00 (20130101) New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 1/02 (20130101) Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 3/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220193217 | GLADUE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | DOUGLAS P. GLADUE (GUILFORD, Connecticut); MANUEL V. BORCA (WESTBROOK, Connecticut) |
| ABSTRACT | Provided herein are details on the construction of a recombinant African Swine Fever Virus (ASFV) live attenuated vaccine for prevention of ASF caused by various strains of ASFV, such as the highly virulent Georgia 2007 isolate (“ASFV-G”). An exemplary vaccine comprises a deletion of multiple genes allowing for industrial-scale growth in stable cell lines. |
| FILED | Tuesday, December 22, 2020 |
| APPL NO | 17/130814 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class A61K 2039/5254 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220195435 | HUNTER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | WAYNE B. HUNTER (PORT SAINT LUCIE, Florida); SALVADOR P. LOPEZ (VERO BEACH, Florida) |
| ABSTRACT | The present disclosure provides oligonucleotides and double-stranded RNAs (dsRNAs) targeting Hemipteran and Lepidopteran insect pests. Bantam-sequence targets are detailed and shown to be effective targets for RNAi induction utilizing multiple dsRNAs, antisense oligonucleotides, and modified dsRNAs (e.g., 2′-O-methylated and dsRNAs containing non-canonical nucleosides). |
| FILED | Friday, December 17, 2021 |
| APPL NO | 17/554026 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 63/60 (20200101) Biocidal, Pest Repellant, Pest Attractant or Plant Growth Regulatory Activity of Chemical Compounds or Preparations A01P 7/04 (20210801) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/321 (20130101) C12N 2310/322 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220196656 | Kapur et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Penn State Research Foundation (Pennsylvania, Pennsylvania); The Secretary of State for Environment, Food and Rural Affairs acting through the Animal and Plant (Surrey, United Kingdom) |
| ASSIGNEE(S) | The Penn State Research Foundation (Pennsylvania, None); The Secretary of State for Environment, Food and Rural Affairs acting through the Animal and Plant (Surrey, United Kingdom) |
| INVENTOR(S) | Vivek Kapur (Pennsylvania, None); Sreenidhi Srinivasan (Pennsylvania, None); Hans Vordermeier (Surrey, United Kingdom); Gareth Jones (Surrey, United Kingdom) |
| ABSTRACT | There is provided a skin test diagnostic reagent comprising: at least one 40mer polypeptide consisting of any one of SEQ ID NOs: 1, 3 or 4; at least one 40mer polypeptide consisting of any one of SEQ ID NOs: 7 or 8; and at least one 40mer polypeptide consisting of any one of SEQ ID NOs: 10, 11 or 12, characterised in that the reagent elicits a positive result when administered in a skin test to an animal infected with Mycobacterium bovis or Mycobacterium tuberculosis. |
| FILED | Thursday, April 09, 2020 |
| APPL NO | 17/602628 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5695 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20220198105 | NIROULA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | IONQ, INC. (College Park, Maryland); University of Maryland (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pradeep NIROULA (College Park, Maryland); Wengang ZHANG (Gaithersburg, Maryland); Yunseong NAM (North Bethesda, Maryland) |
| ABSTRACT | A method of performing a computational process includes transforming, a first register of a quantum processor to a charge encoded state in which charges of interacting particles to be simulated are encoded, transforming a second register of the quantum processor to a position encoded state in which positions of the interacting particles are encoded, performing a first phase shift operation, including shifting a phase of the first and second registers by kinetic energies of the interacting particles, performing a second phase shift operation, including shifting the phase of the first and second registers by pair-wise Coulomb potential energies of the interacting particles, measuring the phase of the first and second registers, transmitting the measured phase of the first and second registers to a classical computer, and the measured phase including a sum of the kinetic energies and the pair-wise Coulomb potential energies of the interacting particles. |
| FILED | Friday, November 19, 2021 |
| APPL NO | 17/531366 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/25 (20200101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 10/80 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220199310 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgetown University (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kai Liu (Falls Church, Virginia); Gong Chen (El Cerrito, California); Andreas Schmid (Berkeley, California) |
| ABSTRACT | Embodiments may provide a realization of strong Dzyaloshinskii-Moriya interaction (DMI) and perpendicular magnetic anisotropy (PMA) induced by chemisorbed species on a ferromagnetic layer. For example, in an embodiment, an apparatus for generating DMI may comprise a ferromagnet comprising a single-layer or multi-layers of materials made of metal, oxide or other types of magnetic films, and a substance chemisorbed on a surface of the ferromagnet to induce the DMI or the PMA at the interface between the chemisorbed species and the ferromagnet. These induced effects may be used to maniupulate spin textures such as switching of domain wall chirality and writing/deleting of magnetic skyrmions, which are relevant for spintronics and magneto-ionics as well as for gas sensing. |
| FILED | Monday, March 14, 2022 |
| APPL NO | 17/694548 |
| CURRENT CPC | Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 10/3236 (20130101) Original (OR) Class H01F 10/3281 (20130101) H01F 41/303 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Security Agency (NSA)
| US 20220200900 | Roweth |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hewlett Packard Enterprise Development LP (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Duncan Roweth (Bristol Avon, United Kingdom) |
| ABSTRACT | System and methods are described for providing adaptive routing in the presence of persistent flows. Switches in a fabric have the capability to establish flow channels. Switches can adaptively route flows, while monitoring transmission characteristics of the flows channels to identify whether any flows are experiencing congestion towards a destination. In response to detecting congestion, it can be further determined whether the flow is related to a source of congestion, or alternative the flow is a victim of congestion. Flows that are a source of congestion have their routing constrained to prevent congestion from propagating. For example, new packets of a flow that is a source of congestion may be forced to only take the path of the data transmission that detected said congestion (preventing congestion from spreading). Alternatively, victims of congestion do not have their routing constrained, and packets can take any path as permitted by adaptive routing. |
| FILED | Monday, March 23, 2020 |
| APPL NO | 17/594721 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 45/021 (20130101) H04L 45/22 (20130101) H04L 45/28 (20130101) H04L 45/38 (20130101) Original (OR) Class H04L 47/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220201894 | Cader et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HEWLETT PACKARD ENTERPRISE DEVELOPMENT LP (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tahir Cader (Liberty Lake, Washington); Harvey J. Lunsman (Chippewa Falls, Wisconsin); Mitchell Johnson (Madison, Wisconsin) |
| ABSTRACT | A compute device includes a printed circuit board, at least three compute subassemblies disposed on the printed circuit board, and a liquid loop. The compute subassemblies disposed on the printed circuit board and each of the three compute subassemblies includes a thermal control plate defining a respective internal conduit therethrough. A temperature controlled liquid circuit circulates through the liquid loop through to control the temperature of each of compute subassemblies in series during operation, the liquid loop including each of the internal conduits in each of the thermal control plates in each of the compute subassemblies. |
| FILED | Friday, December 18, 2020 |
| APPL NO | 17/126361 |
| CURRENT CPC | Electric Digital Data Processing G06F 1/20 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 7/2039 (20130101) H05K 7/20218 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20220192183 | Cope et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Accelerated Ag Technologies, LLC (Ames, Iowa) |
| ASSIGNEE(S) | Accelerated Ag Technologies, LLC (Ames, Iowa) |
| INVENTOR(S) | Jason Cope (Ankeny, Iowa); George Singletary (Ankeny, Iowa); Todd Krone (Des Moines, Iowa); Sara Katherine Etter (Bondurant, Iowa) |
| ABSTRACT | Described are methods of preserving cereal crop pollen and/or anthers. A method of the present invention includes collecting fresh pollen and/or anthers and introducing the pollen and/or anthers to field conditioning conditions which regulate pollen moisture content. The field conditioning conditions may include a an air flow at a humidity ranging from 0% to about 99% and a temperature ranging from about −10-10° C. The field conditioning conditions may further include a flow of one or more continuously refreshed, selected gases. The field conditioning conditions may dehydrate the pollen to achieve a pollen moisture content of about 15% to about 35%. |
| FILED | Friday, March 04, 2022 |
| APPL NO | 17/686939 |
| CURRENT CPC | Horticulture; Cultivation of Vegetables, Flowers, Rice, Fruit, Vines, Hops or Seaweed; Forestry; Watering A01G 7/00 (20130101) New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 1/02 (20130101) Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 3/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220199987 | YUSHIN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sila Nanotechnologies Inc. (Alameda, California) |
| ASSIGNEE(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| INVENTOR(S) | Gleb YUSHIN (Atlanta, Georgia); Oleksandr MAGAZYNSKYY (Atlanta, Georgia); Patrick DIXON (Dunwoody, Georgia); Benjamin HERTZBERG (New York, New York) |
| ABSTRACT | Described herein are improved composite anodes and lithium-ion batteries made therefrom. Further described are methods of making and using the improved anodes and batteries. In general, the anodes include a porous composite having a plurality of agglomerated nanocomposites. At least one of the plurality of agglomerated nanocomposites is formed from a dendritic particle, which is a three-dimensional, randomly-ordered assembly of nanoparticles of an electrically conducting material and a plurality of discrete non-porous nanoparticles of a non-carbon Group 4A element or mixture thereof disposed on a surface of the dendritic particle. At least one nanocomposite of the plurality of agglomerated nanocomposites has at least a portion of its dendritic particle in electrical communication with at least a portion of a dendritic particle of an adjacent nanocomposite in the plurality of agglomerated nanocomposites. |
| FILED | Thursday, March 10, 2022 |
| APPL NO | 17/692030 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/38 (20130101) H01M 4/133 (20130101) H01M 4/134 (20130101) H01M 4/137 (20130101) H01M 4/366 (20130101) Original (OR) Class H01M 4/587 (20130101) H01M 4/602 (20130101) H01M 4/625 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Justice (DOJ)
| US 20220197987 | Khorshid et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ahmed Eissa Fathy Khorshid (Oakland, California); Ahmed Mohamed Eltawil (Oakland, California); Roger Piqueras Jover (Brooklyn, New York) |
| ABSTRACT | Biometric identification through intra-body communication is described. In one embodiment, a system for biometric identification includes a biometric transmitter device and a biometric receiver device. The biometric transmitter device includes at least one transmit electrode for contact with skin of an individual at a first location on the skin, and the biometric transmitter device is configured to transmit a signal through the transmit electrode and the skin. The biometric receiver device includes at least one receive electrode for contact with the skin of the individual at a second location on the skin, and the biometric receiver is configured to receive the signal through the receive electrode for biometric authentication of the individual. |
| FILED | Friday, May 15, 2020 |
| APPL NO | 17/604643 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/32 (20130101) Original (OR) Class G06F 2221/2103 (20130101) Image or Video Recognition or Understanding G06V 40/1306 (20220101) G06V 40/1365 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
European Union (EU)
| US 20220196749 | Kriston et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The European Union, Represented by the European Commission (Brussels, Belgium) |
| ASSIGNEE(S) | The European Union, Represented by the European Commission (Brussels, Belgium) |
| INVENTOR(S) | Akos Kriston (Ispra, Italy); Andreas Pfrang (Alkmaar, Netherlands) |
| ABSTRACT | A computer-implemented method for electrochemical impedance spectroscopy of an electrochemical cell. The method comprises: applying a periodic perturbation with a predetermined carrier wave form on the potential or the current; simultaneously measuring an influence of the periodic perturbation on the other one of the potential or the current and a displacement or a stress of a working electrode of the electrochemical cell; extracting, using lock-in amplifiers, from the other one of the potential or the current an electrical parameter signal with the predetermined carrier wave form and from the displacement or a stress measurement signal a mechanical parameter signal with the predetermined carrier wave form. This enables measuring a response in two different physical parameters from applying a single periodic perturbation to yet another physical parameter. By analysing the extracted signal components, information on coupling effects between the electrochemical behaviour and the mechanical behaviour of the electrochemical cell are uncovered. |
| FILED | Thursday, April 30, 2020 |
| APPL NO | 17/605790 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/389 (20190101) Original (OR) Class G01R 31/3842 (20190101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/48 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Reconnaissance Office (NRO)
| US 20220195964 | Lozano et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Paulo C. Lozano (Arlington, Massachusetts); Dakota Freeman (Cambridge, Massachusetts); Jonathan MacArthur (Columbus, Nebraska) |
| ABSTRACT | Electrical propulsion systems and related methods are generally described. In some embodiments, an electrical propulsion system may include an electrically-actuated valve to selectively permit flow of propellant from a reservoir tank to a thruster. The valve may physically isolate the propellant from the thruster when inactivated, exhibiting a non-wetting surface which may inhibit propellant from passing through the valve towards the thrusters. In some embodiments, a valve may be activated through application of a voltage potential to the valve relative to the propellant, which may change the wettability of the valve, permitting propellant to wet and subsequently pass through the valve. The voltage potential may be adjusted to vary the wettability of the valve, resulting in the valve effectively regulating propellant flow rate. The valve may include a conductive layer, a dielectric or insulating layer, and a non-wetting layer to enhance the non-wetting behavior of the valve. |
| FILED | Wednesday, October 20, 2021 |
| APPL NO | 17/506411 |
| CURRENT CPC | Jet-propulsion Plants F02K 9/58 (20130101) Original (OR) Class Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 13/00 (20130101) F16K 31/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Non-Profit Organization (NPO)
| US 20220199310 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgetown University (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kai Liu (Falls Church, Virginia); Gong Chen (El Cerrito, California); Andreas Schmid (Berkeley, California) |
| ABSTRACT | Embodiments may provide a realization of strong Dzyaloshinskii-Moriya interaction (DMI) and perpendicular magnetic anisotropy (PMA) induced by chemisorbed species on a ferromagnetic layer. For example, in an embodiment, an apparatus for generating DMI may comprise a ferromagnet comprising a single-layer or multi-layers of materials made of metal, oxide or other types of magnetic films, and a substance chemisorbed on a surface of the ferromagnet to induce the DMI or the PMA at the interface between the chemisorbed species and the ferromagnet. These induced effects may be used to maniupulate spin textures such as switching of domain wall chirality and writing/deleting of magnetic skyrmions, which are relevant for spintronics and magneto-ionics as well as for gas sensing. |
| FILED | Monday, March 14, 2022 |
| APPL NO | 17/694548 |
| CURRENT CPC | Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 10/3236 (20130101) Original (OR) Class H01F 10/3281 (20130101) H01F 41/303 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Nuclear Regulatory Commission (NRC)
| US 20220195297 | Yang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ge Yang (Raleigh, North Carolina); Zheng Zhang (Raleigh, North Carolina) |
| ABSTRACT | In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, the disclosure, in one aspect, relates to compound Bi-poor perovskite crystals, methods for making the same, and ionizing and other electromagnetic radiation detectors constructed using the Bi-poor perovskite crystals. The Bi-poor perovskite crystals can be synthesized using melt-based growth methods and solution-based growth methods and contain no toxic heavy metals such as lead, cadmium, thallium, or mercury. Devices fabricated from the crystals maintain acceptable levels of performance over time. In some aspects, post-growth annealing can be used to improve the properties, including, but not limited to, room temperature resistivity and response to radiation. |
| FILED | Friday, December 17, 2021 |
| APPL NO | 17/644886 |
| CURRENT CPC | Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 29/006 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/34 (20130101) C01P 2002/72 (20130101) C01P 2002/74 (20130101) C01P 2002/77 (20130101) C01P 2002/88 (20130101) C01P 2004/02 (20130101) C01P 2006/40 (20130101) C01P 2006/80 (20130101) C01P 2006/90 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/7435 (20130101) Original (OR) Class Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 7/14 (20130101) C30B 29/12 (20130101) Measurement of Nuclear or X-radiation G01T 1/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
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How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, June 23, 2022.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
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APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
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- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
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