FedInvent™ Patent Applications
Application Details for Thursday, June 30, 2022
This page was updated on Friday, July 01, 2022 at 11:39 PM GMT
Department of Health and Human Services (HHS)
| US 20220202356 | McAlindon et al. |
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| FUNDED BY |
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| APPLICANT(S) | Tufts Medical Center, Inc. (Boston, Massachusetts); Trustees of Boston University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Timothy McAlindon (Arlington, Massachusetts); Jeffrey B. Driban (Arlington, Massachusetts); Lori Lyn Price (Winchester, Massachusetts); Michael Lavalley (Arlington, Massachusetts); Ming Zhang (Westford, Massachusetts) |
| ABSTRACT | Determining a composite score includes deriving, based on an image set that includes at least one three-dimensional image of the synovial joint, first and second information. The first information indicates cumulative damage to the synovial joint. The second information indicates either one or both joint pain and loss of function of the synovial joint. The resulting composite score provides an objective measure of joint damage or an extent of joint disease. |
| FILED | Thursday, May 07, 2020 |
| APPL NO | 17/609226 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/1073 (20130101) A61B 5/4514 (20130101) A61B 5/4528 (20130101) Original (OR) Class A61B 5/4842 (20130101) A61B 5/7275 (20130101) Image Data Processing or Generation, in General G06T 7/0016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220202701 | Yu |
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| FUNDED BY |
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| APPLICANT(S) | Wayne State University (Detroit, Michigan) |
| ASSIGNEE(S) | Wayne State University (Detroit, Michigan) |
| INVENTOR(S) | Fu-Shin X. Yu (Troy, Michigan) |
| ABSTRACT | The present disclosure describes compositions and methods to promote wound healing. The compositions and methods include an interleukin-1 beta (IL-1β) receptor antagonist (IL-1Ra), such as anakinra. The IL-1Ra can be administered topically to a chronic wound including a diabetic ulcer. |
| FILED | Tuesday, March 15, 2022 |
| APPL NO | 17/695564 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/0014 (20130101) Original (OR) Class A61K 9/0019 (20130101) A61K 38/1793 (20130101) A61K 38/1858 (20130101) A61K 47/02 (20130101) A61K 47/38 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 15/18 (20130101) A61L 15/28 (20130101) A61L 15/44 (20130101) A61L 15/60 (20130101) A61L 26/008 (20130101) A61L 26/0066 (20130101) A61L 2300/414 (20130101) A61L 2300/426 (20130101) A61L 2300/432 (20130101) A61L 2300/436 (20130101) A61L 2430/32 (20130101) A61L 2430/34 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/02 (20180101) A61P 25/00 (20180101) A61P 27/02 (20180101) Peptides C07K 14/545 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220202705 | Fedorchak et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Morgan V. Fedorchak (Mars, Pennsylvania); Steven R. Little (Allison Park, Pennsylvania); Joel S. Schuman (New York, New York) |
| ABSTRACT | A method for sustained delivery of an agent to an ocular organ in a subject, comprising topically delivering to the ocular surface a liquid thermoresponsive hydrogel comprising agent-loaded polymer microparticles, wherein the agent is an antibody, a fusion protein, a chemokine, an interleukin, a growth factor, albumin, immunoglobulin, an interferon, a peptide, stem cell-conditioned media, plasma or serum. |
| FILED | Tuesday, January 18, 2022 |
| APPL NO | 17/577816 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/10 (20130101) A61K 9/0048 (20130101) Original (OR) Class A61K 9/5031 (20130101) A61K 31/498 (20130101) A61K 38/185 (20130101) A61K 47/32 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220202727 | Shin et al. |
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| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jae-Won Shin (Cambridge, Massachusetts); Angelo S. Mao (Cambridge, Massachusetts); Stefanie Utech (Cambridge, Massachusetts); David A. Weitz (Bolton, Massachusetts); David J. Mooney (Sudbury, Massachusetts); Oktay R. Uzun (Boston, Massachusetts) |
| ABSTRACT | The present invention provides injectable compositions comprising cells encapsulated in hydrogel capsules and methods of preparing these compostions. The present invention also provides methods for using these compositions to promote hematopoiesis and to treat or prevent cardiovascular and immunological disorders in a subject. |
| FILED | Thursday, December 09, 2021 |
| APPL NO | 17/546489 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/4816 (20130101) Original (OR) Class A61K 9/5036 (20130101) A61K 9/5052 (20130101) A61K 35/12 (20130101) A61K 35/28 (20130101) A61K 2035/124 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 11/04 (20130101) C12N 11/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220202744 | HAMMOCK et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
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| INVENTOR(S) | Bruce D. HAMMOCK (Davis, California); Christophe MORISSEAU (West Sacramento, California); Jun YANG (Davis, California); Kenji HASHIMOTO (Chiba, Japan) |
| ABSTRACT | This invention provides methods for preventing, mitigating, ameliorating and/or controlling psychiatric disorders, including depression, major depression, bipolar disorder, schizophrenia and substance abuse (including addiction and dependence) by administration of an agent that increases epoxy-fatty acids (e.g., an inhibitor of soluble epoxide hydrolase), as sole active agent or in combination with another agent (e.g., an antidepressant, an antipsychotic, an anxiolytic). When co-administered in combination with another agent, one or both agent may be administered at a subtherapeutic dose. |
| FILED | Monday, September 13, 2021 |
| APPL NO | 17/473676 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/15 (20130101) A61K 31/135 (20130101) A61K 31/137 (20130101) Original (OR) Class A61K 31/138 (20130101) A61K 31/165 (20130101) A61K 31/185 (20130101) A61K 31/336 (20130101) A61K 31/343 (20130101) A61K 31/352 (20130101) A61K 31/381 (20130101) A61K 31/4525 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/18 (20180101) A61P 25/24 (20180101) A61P 25/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220202747 | Mukhopadhyay et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Somshuvra Mukhopadhyay (Austin, Texas); Andrey S. Selyunin (Kyle, Texas); Stanton F. McHardy (San Antonio, Texas) |
| ABSTRACT | Methods for treating Shiga toxicosis, caused by infection with Shiga toxin bacteria, are provided. The methods include administering to a subject in need thereof an effective amount of one or more active agents selected from tamoxifen, 4-hydroxytamoxifen, endoxifen, toremifene, raloxifene, bazedoxifene, and pharmaceutically acceptable salts thereof. In some embodiments, the methods further include the administration of an antibiotic or a manganese compound to the subject. Pharmaceutical compositions for the treatment of Shiga toxicosis are also described. |
| FILED | Friday, March 18, 2022 |
| APPL NO | 17/698527 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 31/138 (20130101) Original (OR) Class A61K 31/4535 (20130101) A61K 33/32 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220202763 | ROSEN et al. |
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| FUNDED BY |
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| APPLICANT(S) | BARRY PHILIP ROSEN (CORAL GABLES, Florida); MASAFUMI YOSHINAGA (DORAL, Florida) |
| ASSIGNEE(S) | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (MIAMI, Florida) |
| INVENTOR(S) | BARRY PHILIP ROSEN (CORAL GABLES, Florida); MASAFUMI YOSHINAGA (DORAL, Florida) |
| ABSTRACT | Certain embodiments of the invention pertain to a method of treating an infection in a subject caused by an infectious agent other than Escherichia coli, the method comprising administering to the subject arsinothricin or a salt thereof. The infectious agent other than E. coli can be a bacterium, protozoan, helminth, archaebacterium, or a fungus. In preferred embodiments, the infectious agent is Mycobacterium tuberculosis, Mycobacterium bovis, or Enterobacter cloacae. The invention also pertains to a method of treating an infection in a subject caused by an infectious agent, comprising administering to the subject arsinothricin or a salt thereof in combination with an inhibitor of phosphinothricin N-acetyltransferase or arsinothricin N-acetyltransferase. In certain such embodiments, the infectious agent expresses phosphinothricin N-acetyltransferase or arsinothricin N-acetyltransferase. Further embodiments provide compositions comprising arsinothricin or a salt thereof and an inhibitor of phosphinothricin N-acetyltransferase or arsinothricin N-acetyltransferase. |
| FILED | Wednesday, March 16, 2022 |
| APPL NO | 17/696267 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/285 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1029 (20130101) Enzymes C12Y 203/01183 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220202769 | Boger et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland); UNIVERSITY OF NEBRASKA MEDICAL CENTER (Omaha, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ravit Boger (Baltimore, Maryland); Jonathan Vennerstrom (Omaha, Nebraska) |
| ABSTRACT | Described are methods of treating or preventing a virus in a subject comprising administering ozonides to the subject. |
| FILED | Thursday, January 06, 2022 |
| APPL NO | 17/570376 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/357 (20130101) Original (OR) Class A61K 31/4525 (20130101) A61K 31/5377 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/22 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220202772 | Tumer et al. |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nilgun E. Tumer (Belle Mead, New Jersey); Xiao-Ping Li (Flemington, New Jersey) |
| ABSTRACT | The disclosure provides in one aspect a method of treating, ameliorating, and/or preventing toxicity caused by a ribosome inactivating protein (RIP) in a subject. In certain embodiments, the method comprises administering to the subject a therapeutically effective amount of at least one compound of the disclosure. |
| FILED | Wednesday, March 09, 2022 |
| APPL NO | 17/690251 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/34 (20130101) A61K 31/40 (20130101) A61K 31/41 (20130101) A61K 31/69 (20130101) A61K 31/381 (20130101) Original (OR) Class A61K 31/426 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 39/02 (20180101) Heterocyclic Compounds C07D 207/337 (20130101) C07D 277/56 (20130101) C07D 307/54 (20130101) C07D 333/24 (20130101) C07D 333/34 (20130101) C07D 333/38 (20130101) C07D 333/40 (20130101) C07D 333/70 (20130101) C07D 409/04 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220202785 | HONG et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles C. HONG (Baltimore, Maryland); Charles H. Williams (Odenton, Maryland); Latur Ravithej SINGH (Hyderbad, India) |
| ABSTRACT | The invention relates to a class of small molecule inhibitors of GPR68/OGR1, a proton-sensing/stretch-sensing/sheer-stress-sending G-protein coupled receptor, and related receptors GPR4 and GPR65. These inhibitors are useful as a therapeutic for glioblastoma and other neoplasms, as a monotherapy or adjuvant, and also can be used as a treatment for other conditions, such as osteoporosis, inflammatory bowel disease, autoimmune and chronic inflammatory diseases such as multiple sclerosis and inflammatory pain syndromes, GERD, aspiration pneumonitis, bacterial and viral pneumonia, COPD, acute respiratory distress syndrome (ARDS), and COVID-19. |
| FILED | Friday, April 17, 2020 |
| APPL NO | 17/602101 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/56 (20130101) A61K 31/433 (20130101) Original (OR) Class A61K 31/495 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220202792 | McKEON et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Houston System (Houston, Texas); The Board of Rgents of The University of Texas System (Austin, Texas); Tract Pharmaceuticals, Inc. (West Hartford, Connecticut) |
| ASSIGNEE(S) | University of Houston System (Houston, Texas); The Board of Regents of The University of Texas System (Austin, Texas); Tract Pharmaceuticals, Inc. (West Hartford, Connecticut) |
| INVENTOR(S) | Frank McKEON (Sugar Land, Texas); Marcin DULEBA (Houston, Texas); Yanting ZHANG (Houston, Texas); Jingzhong XIE (Houston, Texas); Wa XIAN (Sugar Land, Texas); Matthew VINCENT (Amesbury, Massachusetts) |
| ABSTRACT | The present disclosure provides methods and formulations for treating a patient suffering from one or more of chronic inflammatory injury, metaplasia, dysplasia or cancer of an epithelial tissue, which method comprises administering to the patient an agent that selectively kills or inhibits the proliferation or differentiation of pathogenic epithelial stem cells (PESCs) relative to normal epithelial stem cells in the tissue in which the PESCs are found. Representative epithelial tissues include pulmonary, genitourinary, gastrointestinal/esophageal, pancreatic and hepatic tissues. |
| FILED | Friday, April 24, 2020 |
| APPL NO | 17/606445 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/14 (20130101) A61K 9/0024 (20130101) A61K 9/0053 (20130101) A61K 31/44 (20130101) A61K 31/69 (20130101) A61K 31/351 (20130101) A61K 31/381 (20130101) A61K 31/404 (20130101) A61K 31/444 (20130101) Original (OR) Class A61K 31/496 (20130101) A61K 31/506 (20130101) A61K 31/517 (20130101) A61K 31/553 (20130101) A61K 31/675 (20130101) A61K 31/4709 (20130101) A61K 31/5025 (20130101) A61K 31/5377 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220202800 | Vockley et al. |
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| APPLICANT(S) | University of Pittsburgh-of the Common wealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gerard Vockley (Pittsburgh, Pennsylvania); Peter Wipf (Pittsburgh, Pennsylvania); Al-Walid A. Mohsen (Gibsonia, Pennsylvania) |
| ABSTRACT | Methods of treating a patient having an organic acidemia or a defect in mitochondria chain oxidation are provided. The methods comprise treating the patient with an effective amount of a mitochondria-targeting reactive oxygen species scavenger. |
| FILED | Thursday, December 23, 2021 |
| APPL NO | 17/560783 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/454 (20130101) Original (OR) Class A61K 31/4468 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/08 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220202811 | Reya et al. |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
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| INVENTOR(S) | Tannishtha Reya (San Diego, California); Nikki Lytle (La Jolla, California) |
| ABSTRACT | Described are compositions and methods for the treatment of an RORγ-dependent cancer, including pancreatic cancer, lung cancer, leukemia, etc. In some example implementations, pharmaceutical compositions for cancer treatment comprising RORγ inhibitors and optionally other therapeutic agents, as well as methods of treating cancer using the pharmaceutical compositions are disclosed. |
| FILED | Thursday, February 20, 2020 |
| APPL NO | 17/432485 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/496 (20130101) Original (OR) Class A61K 31/4035 (20130101) A61K 31/4155 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220202821 | TAINER et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas); Board of Trustees of The University of Arkansas (Little Rock, Arkansas); Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas); Board of Trustees of The University of Arkansas (Little Rock, Arkansas); Washington University (St. Louis, Missouri) |
| INVENTOR(S) | John A. TAINER (Houston, Texas); Zamal AHMED (Houston, Texas); Darin E. JONES (Little Rock, Arkansas); In-Kwon KIM (St. Louis, Missouri); Tom ELLENBERGER (St. Louis, Missouri); Chris HO (St. Louis, Missouri) |
| ABSTRACT | The present disclosure provides methods of inhibiting PARG in cancer cells, including methods comprising administering a PARG inhibitor that modulates position Tyr795 in PARG. Also provided herein are methods of treating and/or preventing cancer comprising administering a PARG inhibitor. In some embodiments, the PARG inhibitors are of the formula: wherein the variables are defined herein. |
| FILED | Friday, March 27, 2020 |
| APPL NO | 17/600049 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/522 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220202832 | ROGAWSKI et al. |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael A. ROGAWSKI (Sacramento, California); Dorota ZOLKOWSKA (Sacramento, California) |
| ABSTRACT | This disclosure is related to non-invasive methods of treating, preventing, inhibiting, delaying, and/or mitigating conditions that are modulated by physiological levels of allopregnanolone and are susceptible to allopregnanolone therapy. |
| FILED | Monday, April 06, 2020 |
| APPL NO | 17/601705 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0043 (20130101) A61K 31/573 (20130101) Original (OR) Class A61K 31/5513 (20130101) A61K 31/5517 (20130101) A61K 47/6951 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/08 (20180101) A61P 25/14 (20180101) A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220202837 | Bertozzi et al. |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carolyn Ruth Bertozzi (Berkeley, California); Nicholas J. Agard (Berkeley, California); Jennifer A. Prescher (Berkeley, California); Jeremy Michael Baskin (Berkeley, California); Ellen May Sletten (Berkeley, California) |
| ABSTRACT | The present invention provides modified cycloalkyne compounds; and method of use of such compounds in modifying biomolecules. The present invention features a cycloaddition reaction that can be carried out under physiological conditions. In general, the invention involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids). |
| FILED | Tuesday, February 15, 2022 |
| APPL NO | 17/672508 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/655 (20130101) Original (OR) Class Acyclic or Carbocyclic Compounds C07C 45/63 (20130101) C07C 45/292 (20130101) C07C 45/511 (20130101) C07C 49/457 (20130101) C07C 49/753 (20130101) C07C 57/26 (20130101) C07C 59/72 (20130101) C07C 63/66 (20130101) C07C 63/74 (20130101) C07C 69/76 (20130101) C07C 69/708 (20130101) C07C 2601/18 (20170501) Heterocyclic Compounds C07D 207/416 (20130101) C07D 207/452 (20130101) C07D 249/16 (20130101) C07D 495/04 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/531 (20130101) G01N 33/6803 (20130101) G01N 33/6842 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220202845 | Bradley et al. |
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| FUNDED BY |
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| APPLICANT(S) | Fred Hutchinson Cancer Research Center (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Bradley (Seattle, Washington); Guo-Liang Chew (Seattle, Washington); Amy Campbell (Seattle, Washington); Stephen Tapscott (Seattle, Washington) |
| ABSTRACT | DUX4 can be used as a biomarker for predicting a patient's response to immunotherapy, and inhibition of DUX4 can be used in therapeutic methods for treating DUX4+ cancers. Accordingly, aspects of the disclosure relate to a method for treating cancer in a patient comprising administering a DUX4 inhibitor to the patient. Further aspects of the disclosure relate to a method for treating a DUX4+ cancer in a patient, the method comprising administering a checkpoint inhibitor to the patient. Other aspects relate to a composition comprising a DUX4 inhibitor and a checkpoint inhibitor. |
| FILED | Thursday, July 25, 2019 |
| APPL NO | 17/264713 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/506 (20130101) A61K 31/713 (20130101) Original (OR) Class A61K 45/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220202855 | Rhee et al. |
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| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Catherine Rhee (Melrose, Massachusetts); David T. Scadden (Weston, Massachusetts) |
| ABSTRACT | Described herein are compositions comprising subsets of monocyte having distinct functional properties and methods for using the same to treat infectious disease. |
| FILED | Friday, November 12, 2021 |
| APPL NO | 17/525673 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/15 (20130101) Original (OR) Class A61K 38/191 (20130101) A61K 38/204 (20130101) A61K 38/1774 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220202900 | GILL et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Saar GILL (Philadelphia, Pennsylvania); Miriam Y. KIM (Philadelphia, Pennsylvania) |
| ABSTRACT | The present invention includes compositions and methods utilizing chemically modified CD33-targeting guide RNAs. |
| FILED | Friday, February 21, 2020 |
| APPL NO | 17/432880 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7105 (20130101) A61K 35/17 (20130101) A61K 35/28 (20130101) A61K 38/1774 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220202902 | Yurek et al. |
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| FUNDED BY |
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| APPLICANT(S) | Children's Hospital Medical Center (Cincinnati, Ohio); University of Cincinnati (Cincinnati, Ohio); University of Kentucky Research Foundation (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Yurek (Lexington, Kentucky); Kim B. Seroogey (Loveland, Ohio); Assem Ziady (Cincinnati, Ohio) |
| ABSTRACT | The instant disclosure relates to nanoparticle compositions that may be used for the targeting of certain cells or tissues. The nanoparticles may take a variety of different forms, including non-viral, viral, and lipid nanoparticles, and may utilize a TNF receptor superfamily member 12A (“TWEAKR”) binding region of the TWEAK protein to target a nanoparticle to tissues expressing TWEAKR. The compositions may further comprise a suicide gene optionally under the control of a tissue specific promoter. In further aspects, methods of treating an individual using the disclosed nanoparticle compositions are described. |
| FILED | Wednesday, April 29, 2020 |
| APPL NO | 17/604557 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1641 (20130101) A61K 31/513 (20130101) A61K 31/522 (20130101) A61K 31/4545 (20130101) A61K 38/45 (20130101) A61K 38/51 (20130101) A61K 38/191 (20130101) Original (OR) Class A61K 38/4873 (20130101) A61K 47/42 (20130101) A61K 48/0058 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220202903 | Cox et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Bolder BioTechnology, Inc. (Boulder, Colorado); The Medical College of Wisconsin, Inc. (Milwaukee, Wisconsin); Indiana University Research and Technology Corporation (Indianapolis, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George N. Cox (Louisville, Colorado); Christie M. Orschell (Indianapolis, Indiana); Meetha Manek Medhora (Brookfield, Wisconsin); Brian Fish (Waukesha, Wisconsin) |
| ABSTRACT | Methods and compositions comprising hematopoietic growth factor proteins and/or protein analogs thereof and/or combinations thereof and angiotensin converting enzyme inhibitors to treat the acute and long term adverse effects of radiation exposure in subjects who have been or will be exposed to radiation are disclosed. |
| FILED | Monday, December 13, 2021 |
| APPL NO | 17/548929 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/05 (20130101) A61K 38/193 (20130101) A61K 38/2073 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220202921 | MCLEOD et al. |
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| FUNDED BY |
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| APPLICANT(S) | Alpha-O Peptides AG (Riehen, Switzerland); Massachusetts Institute of Technology (Cambridge, Massachusetts); Emergent BioSolutions Inc. (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rima MCLEOD (Chicago, Illinois); Kamal EL BISSATI (Chicago, Illinois); Ying ZHOU (Chicago, Illinois); Jeff ALEXANDER (Redwood City, California); Steve REED (Seattle, Washington); Peter BURKHARD (Riehen, Switzerland); Mariane MELO (Cambridge, Massachusetts); Darrel IRVINE (Cambridge, Massachusetts); Ron WEISS (Cambridge, Massachusetts); Yuan ZHANG (Cambridge, Massachusetts) |
| ABSTRACT | Disclosed herein are polynucleotides encoding multi-epitope polypeptides and assemblies thereof, and their use for treating or limiting Toxoplasma gondii infection. |
| FILED | Friday, March 11, 2022 |
| APPL NO | 17/692333 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0009 (20130101) A61K 9/0019 (20130101) A61K 39/002 (20130101) Original (OR) Class A61K 39/012 (20130101) A61K 2039/70 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 33/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220202926 | Kawaoka et al. |
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| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (WARF) (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yoshihiro Kawaoka (Middleton, Wisconsin); Gabriele Neumann (Madison, Wisconsin); Jihui Ping (Nanjing, China PRC) |
| ABSTRACT | The invention provides a composition useful to prepare high titer influenza B viruses, e.g., in the absence of helper virus, which includes internal genes from an influenza B virus vaccine strain or isolate, e.g., one that is safe in humans, for instance, one that does not result in significant disease, that confer enhanced growth in cells in culture, such as MDCK cells, or in eggs. |
| FILED | Thursday, December 09, 2021 |
| APPL NO | 17/546835 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/145 (20130101) Original (OR) Class A61K 2039/5258 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) C12N 2760/16221 (20130101) C12N 2760/16222 (20130101) C12N 2760/16234 (20130101) C12N 2760/16251 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220202927 | Kawaoka et al. |
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| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (WARF) (Madison, Wisconsin); The University of Tokyo (Tokyo, Japan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yoshihiro Kawaoka (Middleton, Wisconsin); Shinya Yamada (Bunkyo-ku, Japan); Shiho Chiba (Madison, Wisconsin) |
| ABSTRACT | Modified influenza virus neuraminidases are described herein that improve viral replication, thus improving the yield of vaccine viruses. Expression of such modified. neuraminidases by influenza virus may also stabilize co-expressed hemagglutinins so that the hemagglutinins do not undergo mutation. |
| FILED | Thursday, December 09, 2021 |
| APPL NO | 17/546967 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0043 (20130101) A61K 39/145 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 9/2402 (20130101) C12N 15/63 (20130101) C12N 2760/16021 (20130101) C12N 2760/16022 (20130101) C12N 2760/16034 (20130101) C12N 2760/16051 (20130101) Enzymes C12Y 302/01018 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220202929 | Ingber et al. |
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| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Donald E. Ingber (Boston, Massachusetts); Longlong Si (Boston, Massachusetts); Rachelle Prantil-Baun (Ashlad, Massachusetts) |
| ABSTRACT | This disclosure provides immunogenic compositions and methods of producing immunogenic compositions sufficient to produce an antigen-specific immune response against variant influenza virus strains. Also provided herein are methods of identifying drug-resistant influenza virus strains. |
| FILED | Tuesday, May 19, 2020 |
| APPL NO | 17/613011 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/145 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2760/16121 (20130101) C12N 2760/16122 (20130101) C12N 2760/16151 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220202957 | Mali et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Prashant Mali (La Jolla, California); Ana Moreno (San Diego, California) |
| ABSTRACT | The disclosure provides epigenetic based approaches and methods using genome editing constructs comprising a zinc finger fused with a repressor domain and/or a dCas9 fused with a repressor domain to treat and manage pain in subjects in need of treatment thereof. |
| FILED | Thursday, April 09, 2020 |
| APPL NO | 17/602150 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 2227/105 (20130101) A01K 2267/0356 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 48/005 (20130101) Original (OR) Class A61K 48/0075 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/04 (20180101) Peptides C07K 19/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/86 (20130101) C12N 2310/20 (20170501) C12N 2750/14143 (20130101) C12N 2800/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220202958 | Rivella et al. |
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| FUNDED BY |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York); The Children's Hospital of Philadelphia (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stefano Rivella (New York, New York); Laura Breda (New York, New York); Alisa Dong (New York, New York); Gerd Blobel (Bala Cynwyd, Pennsylvania); Wulan Deng (Ashburn, Virginia) |
| ABSTRACT | Provided are compositions and methods for inducing expression of human beta-globin in erythrocytes for use in prophylaxis and/or therapy of a hemoglobinopathy in an individual. The method generally entails introducing into CD34+ cells a polynucleotide encoding: i) a 5′ long terminal repeat (LTR) and a self-inactivating 3′ LTR; ii) at least one polyadenylation signal; iii) at least one promoter; iv) a globin gene locus control region (LCR); v) an ankyrin insulator element (Ank); vi) a Woodchuck Post-Regulatory Element (WPRE) configured such that the WPRE does not integrate into a target genome; and vii) a sequence that is a reverse complement of a sequence encoding human beta-globin, and can include beta-globin that has a βT87Q mutation. Intron 2 of the beta globin gene can be a complete intron. Modified erythrocyte progenitor cells, recombinant vectors and virions comprising recombinant polynucleotides, and methods of making the vectors and virions are included. |
| FILED | Tuesday, March 15, 2022 |
| APPL NO | 17/694841 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 15/867 (20130101) C12N 2740/15043 (20130101) C12N 2830/40 (20130101) C12N 2830/48 (20130101) C12N 2830/50 (20130101) C12N 2830/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220202961 | Achilefu et al. |
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| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Samuel Achilefu (St. Louis, Missouri); Nalinikanth Kotagiri (St. Louis, Missouri) |
| ABSTRACT | The present disclosure discloses methods and compositions for administering Cerenkov radiation-induced therapy (CRIT). |
| FILED | Friday, October 01, 2021 |
| APPL NO | 17/449766 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 41/0038 (20130101) A61K 41/0057 (20130101) A61K 49/0013 (20130101) A61K 49/0021 (20130101) A61K 49/0056 (20130101) Original (OR) Class A61K 51/0474 (20130101) A61K 51/0482 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220202962 | VOSS et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John VOSS (Woodland, California); Ruiwu LIU (Sacramento, California) |
| ABSTRACT | The present invention provides methods of using nitroxide spin-labeled amyloid beta-binding compounds to image amyloid. The present invention also provides nitroxide spin-labeled amyloid beta-binding compounds. |
| FILED | Friday, July 30, 2021 |
| APPL NO | 17/389674 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/05 (20130101) A61K 31/015 (20130101) A61K 31/53 (20130101) A61K 31/353 (20130101) A61K 31/423 (20130101) A61K 31/428 (20130101) A61K 31/4015 (20130101) A61K 31/4178 (20130101) A61K 31/4184 (20130101) A61K 31/4439 (20130101) A61K 31/4709 (20130101) A61K 49/20 (20130101) Original (OR) Class Heterocyclic Compounds C07D 207/14 (20130101) C07D 207/20 (20130101) C07D 207/273 (20130101) C07D 491/052 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220202964 | Cui et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| INVENTOR(S) | Lina Cui (Gainesville, Florida); Kelton Schleyer (Gainesville, Florida); Jun Liu (Gainesville, Florida) |
| ABSTRACT | The invention relates to compounds that interact with heparanase, uses in heparanase screening, uses in in vitro and in vivo imaging (e g , positron emission tomography (PET) and magnetic resonance imaging (MRI)), methods of synthesis, methods of modulating heparanase activity, and methods of treating disease and disorders associated with heparanase. The compounds of the invention are also useful in treating one or more diseases or disorders associated with the function of heparanase. |
| FILED | Thursday, April 23, 2020 |
| APPL NO | 17/605144 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 6/037 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 49/085 (20130101) A61K 49/106 (20130101) A61K 49/108 (20130101) A61K 51/0491 (20130101) Original (OR) Class Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 17/075 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/40 (20130101) Enzymes C12Y 302/01166 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220202994 | Spiller |
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| FUNDED BY |
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| APPLICANT(S) | Drexel University (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kara Lorraine Spiller (Philadelphia, Pennsylvania) |
| ABSTRACT | The application relates to the delivery of immunomodulatory molecules, including cytokines, to the situs of tissue scaffolds, and wounds including injuries. |
| FILED | Friday, January 07, 2022 |
| APPL NO | 17/570681 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/54 (20130101) Original (OR) Class A61L 2300/252 (20130101) A61L 2300/426 (20130101) A61L 2430/02 (20130101) A61L 2430/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2501/231 (20130101) C12N 2501/2304 (20130101) C12N 2533/90 (20130101) C12N 2537/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220203020 | BRETON et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (Charlottesville, Virginia) |
| ASSIGNEE(S) | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (Charlottesville, Virginia) |
| INVENTOR(S) | Marc D. BRETON (Charlottesville, Virginia); Stephen D. PATEK (Charlottesville, Virginia); Boris P. KOVATCHEV (Charlottesville, Virginia) |
| ABSTRACT | An insulin monitoring system includes one or more processors, one or more computer-readable storage devices, and program instructions stored on at least one of the one or more storage devices for execution by at least one of the one or more processors. The program instructions include: first program instructions to track, in real time, the amount of insulin active in a patient; second program instructions to calculate the amount of insulin need of the patient by tracking the patient's metabolic states; third program instructions to compare the insulin active in the patient with the insulin need of the patient; and fourth program instructions to determine an insulin fault level based on the comparison. |
| FILED | Tuesday, March 15, 2022 |
| APPL NO | 17/694870 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/486 (20130101) A61B 5/746 (20130101) A61B 5/4839 (20130101) A61B 5/4866 (20130101) A61B 5/7275 (20130101) A61B 5/14532 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/142 (20130101) Original (OR) Class A61M 5/168 (20130101) A61M 5/172 (20130101) A61M 5/1723 (20130101) A61M 2005/14208 (20130101) A61M 2205/18 (20130101) A61M 2205/502 (20130101) A61M 2205/507 (20130101) A61M 2205/3576 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/65 (20180101) G16H 20/17 (20180101) G16H 40/60 (20180101) G16H 40/63 (20180101) G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220203029 | Breton et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marc D. Breton (Charlottesville, Virginia); Jose Garcia-Tirado (Charlottesville, Virginia); Patricio Colmegna (Charlottesville, Virginia); John Corbett (Charlottesville, Virginia) |
| ABSTRACT | Provided are a system and method for an artificial pancreas having multi-stage model predictive control to minimize and/or prevent occurrence of hypoglycemia associated with Type 1 diabetes. The control implements predictive modeling of a probability of glucose uptake associated with exercise based on at least one exercise profile for a subject with Type 1 diabetes. Based on the probability, the control implements an automatic adjustment of basal insulin infusion to counteract a risk of exercise-induced hypoglycemia in advance of the subject engaging in the exercise. The control implements adjustment of such infusion based on real-time signaling of exercise likely to induce hypoglycemia. The control implements adjustment of a meal-time bolus to account for delay in glucose uptake resulting from exercise engaged in by the subject. Consequently, the control acts to minimize and/or prevent hypoglycemia from occurring both during and immediately after exercise. |
| FILED | Thursday, May 14, 2020 |
| APPL NO | 17/611323 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4836 (20130101) A61B 5/7275 (20130101) A61B 5/14532 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/1723 (20130101) Original (OR) Class A61M 2205/702 (20130101) A61M 2230/201 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/17 (20180101) G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220203118 | Neitz et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Jay Neitz (Seattle, Washington); Maureen Neitz (Seattle, Washington); James A. Kuchenbecker (Seattle, Washington); Sara S. Patterson (Seattle, Washington); Alexandra Neitz (Seattle, Washington) |
| ABSTRACT | Lighting devices, systems, and methods for selectively activating S cones and L+M cones in a human retina and for regulating the phase of circadian rhythm in a human subject. |
| FILED | Wednesday, May 20, 2020 |
| APPL NO | 17/612061 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/0618 (20130101) Original (OR) Class A61N 2005/0652 (20130101) A61N 2005/0662 (20130101) Non-portable Lighting Devices; Systems Thereof; Vehicle Lighting Devices Specially Adapted for Vehicle Exteriors F21S 6/002 (20130101) F21S 6/004 (20130101) Indexing Scheme Associated With Subclasses F21K, F21L, F21S and F21V, Relating to the Form or the Kind of the Light Sources or of the Colour of the Light Emitted F21Y 2107/30 (20160801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220203361 | Mao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chih-Ping Mao (Baltimore, Maryland); Shih-Chin Wang (Baltimore, Maryland); Jie Xiao (Baltimore, Maryland); Tzyy Choou Wu (Stevenson, Maryland); Chien-Fu Hung (Timmonium, Maryland) |
| ABSTRACT | This document relates to methods and materials for assessing and/or treating mammals (e.g., humans) having, or suspected of having, cancer. For example, methods and materials for identifying a mammal as having cancer are provided. For example, microfluidic devices that can be used to detect one or more target polypeptides (e.g., cancer-specific polypeptides) in a fluid sample obtained from a mammal (e.g., a mammal suspected of having cancer) are provided. |
| FILED | Friday, April 24, 2020 |
| APPL NO | 17/604535 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502707 (20130101) Original (OR) Class B01L 3/502715 (20130101) B01L 2200/12 (20130101) B01L 2200/16 (20130101) B01L 2300/163 (20130101) B01L 2300/0819 (20130101) B01L 2300/0867 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/582 (20130101) G01N 33/6854 (20130101) G01N 33/6893 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220203370 | Choi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yongwon Choi (Bryn Mawr, Pennsylvania); Daeyeon Lee (Wynnewood, Pennsylvania); Junhyong Kim (Narberth, Pennsylvania); Syung Hun Han (Austin, Texas) |
| ABSTRACT | Provided is photoactivated selective release (or PHASR) of droplets from a microwell array enabled by a photoresponsive polymer layer integrated into the microfluidic device. This photoresponsive layer is placed in between a microwell array that traps a large number of droplets and a monolithic flow chamber that can be used for recovery. By using focused light, the photoresponsive layer can either be punctured or induced to create local heating to selectively release droplets. The type of photoacoustic dye and the physical properties of the photoresponsive layer can be engineered to induce either puncture of the membrane or pushing of droplets out of the microwells with low thermal impact on the droplets. This approach has broad application in the field of soft lithography-based microfluidic devices for various applications including photoresponsive valves as well as high throughput single cell sequencing. |
| FILED | Monday, December 27, 2021 |
| APPL NO | 17/562250 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502784 (20130101) Original (OR) Class B01L 2200/027 (20130101) B01L 2200/0689 (20130101) B01L 2300/0663 (20130101) B01L 2300/0829 (20130101) B01L 2300/1872 (20130101) B01L 2400/0442 (20130101) Microstructural Devices or Systems, e.g Micromechanical Devices B81B 1/006 (20130101) B81B 2201/057 (20130101) B81B 2203/033 (20130101) B81B 2203/0338 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1434 (20130101) G01N 2015/0065 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204447 | Hua |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Kansas State University Research Foundation (Manhattan, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Duy H. Hua (Manhattan, Kansas) |
| ABSTRACT | Chiral polyvinylpyrrolidinone (CSPVP), complexes of CSPVP with a core species, such as a bimetallic nanocluster catalyst, and enantioselective oxidation reactions utilizing such complexes are disclosed. The catalytic complexes have exhibited the ability to achieve reaction products have a very high degree of optical purifies. These reaction products can be used as reagents in the synthesis of complex organic molecules, such as bioactive products, and C—H bond oxidation of complex molecules including various drugs and natural products. |
| FILED | Tuesday, February 04, 2020 |
| APPL NO | 17/428070 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 35/026 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Heterocyclic Compounds C07D 205/08 (20130101) Original (OR) Class C07D 207/28 (20130101) C07D 211/78 (20130101) C07D 305/12 (20130101) C07D 307/33 (20130101) C07D 309/30 (20130101) C07D 471/04 (20130101) C07D 471/22 (20130101) C07D 487/04 (20130101) Steroids C07J 1/00 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 126/10 (20130101) C08F 226/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204452 | CHAKRABARTI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (Orlando, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Debopam CHAKRABARTI (Orlando, Florida); YU YUAN (Orlando, Florida); Guang HUANG (Orlando, Florida); Claribel Murillo SOLANO (Orlando, Florida) |
| ABSTRACT | Antimalarial compounds of the formula: in which n is 1 or 2; X is C or N; R1 is a moiety comprising a secondary amine and a tertiary amine joined by a C2 to C4 alkyl chain; and R2 is CF3, F, or H, or an analog, combination, derivative, prodrug, stereoisomer, or pharmaceutically acceptable salt thereof. Pharmaceutical compounds including the antimalarial compounds. Methods of treating or preventing malaria comprising administering an effective amount of the antimalarial compounds. |
| FILED | Friday, April 03, 2020 |
| APPL NO | 17/601151 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 33/06 (20180101) Heterocyclic Compounds C07D 215/46 (20130101) Original (OR) Class C07D 401/04 (20130101) C07D 401/06 (20130101) C07D 405/06 (20130101) C07D 409/06 (20130101) C07D 417/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204463 | Miller et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Notre Dame du Lac (South Bend, Indiana) |
| ASSIGNEE(S) | University of Notre Dame du Lac (South Bend, Indiana) |
| INVENTOR(S) | Marvin J. Miller (South Bend, Indiana); Viktor KRCHNAK (South Bend, Indiana); Rui LIU (South Bend, Indiana) |
| ABSTRACT | Substituted nitrobenzothiazinones (BTZs) are potent antituberculosis prodrugs that are reductively activated to produce nitroso moieties that form covalent adducts with a cysteine residue of decaprenylphospholyl-β-D-ribose-2′-oxi-dase (DprE1) of Mycobacterium tuberculosis (Mtb). The resulting cell wall synthesis inhibition is lethal to Mtb, leading to consideration of development of BTZs for clinical use. The hydride-induced reduction of the nitroaromatic proceeds by reversible formation of the corresponding Meisenheimer complex. Herein we demonstrate that chemical reduction of BTZ043 with NaBD4 followed by reoxidation incorporates deuterium into the core nitro aromatic warhead. Subsequent reduction of the deuterated species is not affected, but, as expected, reoxidation is slowed by the deuterium isotope effect, thus prolonging the lifetime of the active nitroso oxidation state. |
| FILED | Friday, April 03, 2020 |
| APPL NO | 17/602401 |
| CURRENT CPC | Heterocyclic Compounds C07D 279/08 (20130101) Original (OR) Class C07D 491/113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204472 | Hadad et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Hadad (Dublin, Ohio); Christopher Callam (Blacklick, Ohio); Jeremy Beck (Columbus, Ohio); Qinggeng Zhuang (Columbus, Ohio); Andrew Franjesevic (Columbus, Ohio); Thomas Corrigan (Columbus, Ohio); Craig McElroy (Lancaster, Ohio) |
| ABSTRACT | Disclosed herein are compounds, compositions, and methods for reactivating or realkylating aged acetylcholinesterase inhibited by or conjugated to the organophosphorus compound. The organophosphorus compound can be a nerve agent. The acetylcholinesterase can be in the central nerve system (CNS) and/or the peripheral nervous system (PNS) of a subject. Accordingly, methods for ameliorating, diminishing, reversing, treating or preventing the toxic effects of an organophosphorus compound in a subject are provided herein. Methods for prophylactic or therapeutic treatment of exposure to an organophosphorus nerve agent are also provided. |
| FILED | Thursday, March 10, 2022 |
| APPL NO | 17/691745 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) Heterocyclic Compounds C07D 213/65 (20130101) C07D 401/06 (20130101) Original (OR) Class C07D 401/14 (20130101) C07D 413/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204484 | Mallampalli et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | Rama K. Mallampalli (Sewickley, Pennsylvania); Beibei Chen (Sewickley, Pennsylvania); Charleen T. Chu (Wexford, Pennsylvania); Yuan Liu (Sewickley, Pennsylvania) |
| ABSTRACT | A method for treating a neurodegenerative disease or an inflammatory disorder in a subject, comprising administering to the subject in need thereof, a compound, or a pharmaceutically acceptable salt thereof, of formula II: wherein each of R3-R7 is independently H, halogen, optionally-substituted alkyl, amino, alkoxy or hydroxy; R8 is an optionally-substituted heterocycloalkyl; and a is 0 to 3. |
| FILED | Monday, December 13, 2021 |
| APPL NO | 17/548914 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/517 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/16 (20180101) A61P 25/28 (20180101) Heterocyclic Compounds C07D 405/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204485 | Kelly et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Scripps Research Institute (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffery W. Kelly (La Jolla, California); Gareth John Morgan (La Jolla, California); Nicholas Lok Yan (La Jolla, California); Hank Michael James Petrassi (La Jolla, California) |
| ABSTRACT | In immunoglobulin light chain amyloidosis (AL), the unique antibody light chain (LC) protein that is secreted by monoclonal plasma cells in each patient misfolds and/or aggregates, a process leading to organ degeneration. For treating AL patients, such as those with substantial cardiac involvement who have difficulty tolerating existing chemotherapy regimens, provided herein are small molecule compounds of Formula Ia, Formula Ib, and Formula II that are kinetic stabilizers of the native dimeric structure of full-length LCs, which compounds can slow or stop the amyloidogenicity cascade at its origin. |
| FILED | Sunday, March 29, 2020 |
| APPL NO | 17/593812 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 255/30 (20130101) C07C 311/39 (20130101) C07C 317/24 (20130101) Heterocyclic Compounds C07D 207/06 (20130101) C07D 207/48 (20130101) C07D 215/227 (20130101) C07D 233/72 (20130101) C07D 235/02 (20130101) C07D 239/47 (20130101) C07D 311/18 (20130101) C07D 319/06 (20130101) C07D 405/04 (20130101) C07D 405/06 (20130101) C07D 405/12 (20130101) Original (OR) Class C07D 407/12 (20130101) C07D 471/10 (20130101) C07D 487/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204534 | PELZ et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Melinta Subsidiary Corp. (Morristown, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andreas PELZ (Lincolnshire, Illinois); Christian SCHUSTER (Lincolnshire, Illinois); Stefan STEINHOFER (Lincolnshire, Illinois); Clemens STUECKLER (Lincolnshire, Illinois); Maria VASILOIU (Lincolnshire, Illinois); Christopher ZINGANELL (Lincolnshire, Illinois) |
| ABSTRACT | A process for a continuous production of a boronic acid derivative and an apparatus of performing the process are disclosed. |
| FILED | Friday, March 18, 2022 |
| APPL NO | 17/698719 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/02 (20130101) B01J 19/0013 (20130101) B01J 19/248 (20130101) B01J 2219/00033 (20130101) B01J 2219/00099 (20130101) B01J 2219/0286 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/027 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204545 | Moukha-Chafiq et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Southern Research Institute (Birmingham, Alabama); Oregon Health and Science University (Portland, Oregon); Washington University in St. Louis (St. Louis, Missouri); Board of Regents of the University of Texas System and Its Component Institution University of Texas (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Omar Moukha-Chafiq (Hoover, Alabama); Ashish Kumar Pathak (Birmingham, Alabama); Shuklendu D. Karyakarte (Birmingham, Alabama); Larry D. Bratton (Birmingham, Alabama); Corinne E. Augelli-Szafran (Homewood, Alabama); Michael Diamond (St. Louis, Missouri); Pei Yong Shi (Galveston, Texas); Alec Jay Hirsch (Portland, Oregon); Jessica Lee Smith (Beaverton, Oregon); Daniel Streblow (Banks, Oregon); Nicole Haese (Beaverton, Oregon); Baoling Ying (Ballwin, Missouri) |
| ABSTRACT | The present disclosure is concerned with 6-aza-nucleoside prodrugs that are capable of inhibiting a viral infection and methods of treating viral infections such as, for example, human immunodeficiency virus (HIV), human papillomavirus (HPV), chicken pox, infectious mononucleosis, mumps, measles, rubella, shingles, ebola, viral gastroenteritis, viral hepatitis, viral meningitis, human metapneumovirus, human parainfluenza virus type 1, parainfluenza virus type 2, parainfluenza virus type 3, respiratory syncytial virus, viral pneumonia, yellow fever virus, tick-borne encephalitis virus, Chikungunya virus (CHIKV), Venezuelan equine encephalitis (VEEV), Eastern equine encephalitis (EEEV), Western equine encephalitis (WEEV), dengue (DENV), influenza, West Nile virus (WNV), zika (ZIKV), Middle East Respiratory Syndromes (MERS), Severe Acute Respiratory Syndrome (SARS), and coronavirus disease 2019 (COVID-19), using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| FILED | Friday, December 17, 2021 |
| APPL NO | 17/554979 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) A61P 31/16 (20180101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 19/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204548 | Devlin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Abigail Sloan Devlin (Cambridge, Massachusetts); Arijit Adhikari (Cambridge, Massachusetts) |
| ABSTRACT | Described herein are methods and compositions related to inhibiting bile salt hydrolase (BSH) and uses thereof. Provided herein is a method for treating a metabolic disorder (e.g., diabetes, obesity), gastrointestinal disease (e.g., a gastrointestinal infection; inflammatory bowel disease (IBD); appendicitis; Crohn's disease (CD); ulcerative colitis (UC); gastritis; enteritis; esophagitis; pancreatitis; diabetes; hepatitis; liver diseases (e.g., Non-alcoholic Fatty Liver Disease (NAFLD); non-alcoholic steatohepatitis (NASH); hepatitis A; hepatitis B; hepatitis C; autoimmune hepatitis; and cirrhosis of the liver) gastroesophageal reflux disease (GERD); celiac disease; diverticulitis; food intolerance; ulcer; infectious colitis; irritable bowel syndrome; leaky gut; and cancer), cancer (e.g., cancer of the digestive system, liver cancer), or an inflammatory disease (e.g., Crohn's disease, inflammatory bowel disease, ulcerative colitis, pancreatitis, hepatitis, appendicitis, gastritis, diverticulitis, celiac disease, food intolerance, enteritis, ulcer, gastroesophageal reflux disease (GERD), psoriatic arthritis, psoriasis, and rheumatoid arthritis) in a subject in need thereof comprising administering to a subject a compound of Formulae (I)-(XVIII). |
| FILED | Friday, May 08, 2020 |
| APPL NO | 17/610037 |
| CURRENT CPC | Steroids C07J 31/006 (20130101) Original (OR) Class C07J 41/005 (20130101) C07J 41/0027 (20130101) C07J 41/0055 (20130101) C07J 41/0094 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204565 | Chaiken et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DREXEL UNIVERSITY (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Irwin M. Chaiken (Gladwyne, Pennsylvania); Adel Ahmed Rashad Ahmed (Philadelphia, Pennsylvania) |
| ABSTRACT | The present invention includes novel cyclic peptides, and methods of using the same. The present invention further includes novel cyclic peptides conjugated with a gold nanoparticle, and methods of using the same. |
| FILED | Wednesday, December 15, 2021 |
| APPL NO | 17/552087 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 47/6923 (20170801) A61K 47/6929 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Peptides C07K 7/56 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204567 | BRANDENBURG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | JANSSEN VACCINES and PREVENTION B.V. (Leiden, Netherlands) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Boerries BRANDENBURG (Leiden, Netherlands); Tina RITSCHEL (Leiden, Netherlands); Ferdinand Jacobus MILDER (Leiden, Netherlands); Mandy Antonia, Catharina JONGENEELEN (Leiden, Netherlands); Indigo KING (Leiden, Netherlands); Yifan SONG (Leiden, Netherlands); Johannes Petrus, Maria LANGEDIJK (Leiden, Netherlands) |
| ABSTRACT | The invention provides recombinant influenza A hemagglutinin (HA) polypeptides, comprising an HA1 and a HA2 domain of an influenza A virus HA, and comprising an amino acid sequence wherein: (a) the amino acid at position 355 is W; and (b) the amino acid at position 432 is I and/or the amino acid at position 380 is I; and wherein the numbering of the amino acid positions in the amino acid sequence of the HA polypeptide is according to the numbering of amino acids in the amino acid sequence of HA from a reference H3N2 influenza strain, in particular the reference strain H3N2 A/Aichi/2/68 (SEQ ID NO: 1), immunogenic fragments thereof, nucleic acid molecules encoding said polypeptides or immunogenic fragments, and uses thereof. |
| FILED | Thursday, April 23, 2020 |
| APPL NO | 17/594576 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/00 (20130101) Peptides C07K 14/005 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204572 | Walensky et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Loren D. Walensky (Newton, Massachusetts); Ruben Carrasco (Brookline, Massachusetts); Gregory H. Bird (Pelham, New Hampshire) |
| ABSTRACT | The invention provides structurally-constrained peptides by hydrocarbon stapling of a BCL9 HD2 helix for use as a therapeutic agent. The invention further provides methods and kits for use of the structurally-constrained peptide of the instant invention. The invention is based, at least in part, on the results provided herein demonstrating that hydrocarbon stapled helical peptides display excellent proteolytic, acid, and thermal stability, restore the native helical structure of the peptide, possess superior pharmacokinetic properties compared to the corresponding unmodified peptides, and are highly effective in binding to β-catenin in vitro, in cellulo, and in vivo, disrupting the BCL9/β-catenin interaction, and thereby interfering with deregulated Wnt/β-catenin signaling for therapeutic benefit in a variety of human diseases including human cancer. |
| FILED | Friday, November 19, 2021 |
| APPL NO | 17/455831 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/1709 (20130101) A61K 45/06 (20130101) Peptides C07K 14/47 (20130101) Original (OR) Class C07K 14/82 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/53 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204575 | Lim et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wendell A. Lim (San Francisco, California); Jasper Z. Williams (San Francisco, California); Greg Allen (San Francisco, California) |
| ABSTRACT | Provided are methods of modulating the survival of therapeutic cells as well as cells and nucleic acids and vectors useful in such methods. Such survival modulation may include enhancing survival and/or enhancing death of the therapeutic cells. The provided methods include administering a therapeutic cell, nucleic acid and/or vector to a subject, the administered therapeutic cells, nucleic acids and/or vectors including one or more heterologous apoptosis modulating agents and/or one or more encoding sequences thereof. Cells of the disclosure include or encode one or more heterologous apoptosis modulating agents. |
| FILED | Wednesday, April 22, 2020 |
| APPL NO | 17/605198 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 38/00 (20130101) A61K 48/005 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/4747 (20130101) Original (OR) Class C07K 14/7051 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204578 | Garcia et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenan Christopher Garcia (Menlo Park, California); Aron Levin (New York City, New York); Aaron Ring (Menlo Park, California) |
| ABSTRACT | Novel human interleukin-2 (IL-2) muteins or variants thereof, and nucleic acid molecules and variants thereof are provided. Methods for producing these muteins as well as methods for stimulating the immune system of an animal are also disclosed. In addition, the invention provides recombinant expression vectors comprising the nucleic acid molecules of this invention and host cells into which expression vectors have been introduced. Pharmaceutical compositions are included comprising a therapeutically effective amount of a human IL-2 mutein of the invention and a pharmaceutically acceptable carrier. The IL-2 muteins can be used in pharmaceutical compositions for use in treatment of cancer and in stimulating the immune response. |
| FILED | Thursday, September 09, 2021 |
| APPL NO | 17/470246 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/55 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204579 | Bishai et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltmore, Maryland); TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William R. Bishai (Baltimore, Maryland); John R. Murphy (Tilghman, Maryland); Laurene Cheung (Baltimore, Maryland); Shashank Gupta (Frederick, Maryland); Cynthia K. Bullen (Baltimore, Maryland) |
| ABSTRACT | The present invention is a DNA expression vector comprising: a toxP: a mutant toxO that blocks Fe-mediated regulation of gene expression; and a DNA sequence encoding a protein, wherein the toxP and the mutant toxO regulate expression of the DNA segment encoding the protein. It is preferred that DNA expression vectors of the present invention include DNA sequences encoding a signal peptide so that a protein expressed is attached to the signal peptide prior to processing. Novel proteins are produced off of the DNA expression vector of the present invention. |
| FILED | Monday, December 13, 2021 |
| APPL NO | 17/549845 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/34 (20130101) C07K 14/55 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/77 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204583 | Shusta et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin); EMORY UNIVERSITY (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric V. Shusta (Madison, Wisconsin); Jason M. Lajoie (Madison, Wisconsin); Brantley R. Herrin (Madison, Wisconsin) |
| ABSTRACT | The present disclosure provides isolated polypeptides comprising variable lymphocyte receptors that specifically bind the blood brain barrier, compositions, and methods of use. |
| FILED | Tuesday, February 11, 2020 |
| APPL NO | 17/429602 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/68 (20170801) A61K 2039/505 (20130101) Peptides C07K 14/7051 (20130101) Original (OR) Class C07K 16/2881 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204584 | Cafri et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Gal Cafri (Kibbutz Nir David, Israel); Paul F. Robbins (Chevy Chase, Maryland); Steven A. Rosenberg (Potomac, Maryland) |
| ABSTRACT | Disclosed is an isolated or purified T cell receptor (TCR), wherein the TCR has antigenic specificity for mutated Kirsten rat sarcoma viral oncogene homolog (KRAS) presented by a human leukocyte antigen (HLA) Class II molecule. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal. |
| FILED | Friday, March 11, 2022 |
| APPL NO | 17/692787 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 38/177 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/82 (20130101) C07K 14/7051 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/62 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5748 (20130101) G01N 2800/7028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204594 | Goodman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Research Institute at Nationwide Children's Hospital (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven D. Goodman (Hilliard, Ohio); Lauren O. Bakaletz (Hilliard, Ohio) |
| ABSTRACT | This disclosure provides isolated or recombinant polypeptides that are useful to vaccinate individuals suffering from chronic/recurrent biofilm disease or as a therapeutic for those with an existing infection. The individual's immune system will then naturally generate antibodies which prevent or clear these bacteria from the host by interfering with the construction and or maintenance of a functional protective biofilm. Alternatively, antibodies to the polypeptides can be administered to treat or prevent infection. Bacteria that cannot form functional biofilms are more readily cleared by the remainder of the host's immune system and/or traditional antibiotics. |
| FILED | Thursday, December 16, 2021 |
| APPL NO | 17/552986 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 37/46 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 39/40 (20130101) A61K 39/0208 (20130101) A61K 39/39541 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/12 (20130101) C07K 16/40 (20130101) C07K 16/1232 (20130101) C07K 16/1242 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6854 (20130101) G01N 33/6893 (20130101) G01N 33/56911 (20130101) G01N 2800/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204602 | Song et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania); Kira Pharmaceuticals (US) LLC (Arlington, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wenchao Song (Bryn Mawr, Pennsylvania); Takashi Miwa (Bala Cynwyd, Pennsylvania); Damodar Gullipalli (Philadelphia, Pennsylvania); Sayaka Sato (Philadelphia, Pennsylvania); Ping Tsui (North Potomac, Maryland); Yingjie Zhu (Quaker Hill, Connecticut); Xihua Zhu (Suzhou, China PRC) |
| ABSTRACT | This invention relates to inhibition of the complement signaling using an anti-C5 antibody or fusion protein thereof. Specifically, the invention relates to methods of treating a complement-mediated disease or complement-mediated disorder in an individual by contacting the individual with an anti-C5 antibody fusion protein thereof. |
| FILED | Friday, April 24, 2020 |
| APPL NO | 17/605695 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0276 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/02 (20180101) Peptides C07K 14/472 (20130101) C07K 16/18 (20130101) Original (OR) Class C07K 2317/76 (20130101) C07K 2317/565 (20130101) C07K 2319/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204604 | Gazzaniga et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Francesca S. Gazzaniga (Jamaica Plain, Massachusetts); Joon Seok Park (Brookline, Massachusetts); Arlene H. Sharpe (Brookline, Massachusetts); Dennis Kasper (Brookline, Massachusetts) |
| ABSTRACT | Provided herein are methods and compositions for treating cancer or a tumor in a subject by administering to the subject a first agent that disrupts the interaction between PD-L2/RGMb and a second agent that disrupts the interaction between PD-1/PD-L1. The subject may have dysbiosis and/or be nonresponsive to immune checkpoint therapy. |
| FILED | Monday, September 13, 2021 |
| APPL NO | 17/473083 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/431 (20130101) A61K 31/4164 (20130101) A61K 31/7036 (20130101) A61K 38/14 (20130101) A61K 39/3955 (20130101) A61K 2039/545 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/22 (20130101) Original (OR) Class C07K 16/2818 (20130101) C07K 16/2827 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204619 | Kochenderfer |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | James N. Kochenderfer (Bethesda, Maryland) |
| ABSTRACT | The invention is directed to a chimeric antigen receptor (CAR) directed against CD19, which comprises an amino acid sequence of any one of SEQ ID NO: 1-SEQ ID NO: 13. The invention also provides T-cells expressing the CAR and methods for destroying malignant B-cells. |
| FILED | Wednesday, March 16, 2022 |
| APPL NO | 17/696249 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Peptides C07K 14/705 (20130101) C07K 14/7051 (20130101) C07K 14/70517 (20130101) C07K 14/70521 (20130101) C07K 14/70535 (20130101) C07K 14/70578 (20130101) C07K 16/2803 (20130101) Original (OR) Class C07K 16/3061 (20130101) C07K 2317/21 (20130101) C07K 2317/70 (20130101) C07K 2317/622 (20130101) C07K 2319/00 (20130101) C07K 2319/02 (20130101) C07K 2319/03 (20130101) C07K 2319/33 (20130101) C07K 2319/74 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204646 | Dinarello et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a Body Corporate (Denver, Colorado); Konkuk University Industry Cooperation Foundation (Chungju, South Korea) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles A. Dinarello (Denver, Colorado); Soohyun Kim (Greenwood Village, Colorado) |
| ABSTRACT | Embodiments herein report compositions of alpha-1 antitrypsin fusion polypeptides or peptide derivatives thereof. In certain embodiments, compositions and methods relate to generating a construct of use in pharmaceutically acceptable compositions to treat a subject in need of alpha-1 antitrypsin therapy or treatment. In other embodiments, compositions and methods disclosed herein concern linking alpha-1 antitrypsin or derivative thereof to an immune fragment. |
| FILED | Friday, September 10, 2021 |
| APPL NO | 17/471466 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/57 (20130101) Peptides C07K 14/8125 (20130101) C07K 16/40 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/62 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204911 | Stottlemire et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of Kansas (Lawrence, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bryce Stottlemire (Lawrence, Kansas); Mei He (Gainesville, Florida); Cory Berkland (Lawrence, Kansas) |
| ABSTRACT | Described herein is a system to remote-control magnetic actuation of dynamic cell culture. The systems described herein can include a porous, magnetic, elastomeric construct. The porous, magnetic, elastomeric construct can be formed from a composite including a biocompatible elastomer and a population of magnetic particles dispersed within the biocompatible elastomer. |
| FILED | Thursday, December 23, 2021 |
| APPL NO | 17/560870 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/12 (20130101) C12M 25/14 (20130101) C12M 35/02 (20130101) C12M 35/06 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0665 (20130101) C12N 5/0667 (20130101) C12N 2513/00 (20130101) C12N 2533/56 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204925 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Su-Chun Zhang (Waunakee, Wisconsin); Yunlong Tao (Madison, Wisconsin) |
| ABSTRACT | Methods for obtaining populations of norepinephrine (NE) neuronal progenitor cells and creating enriched populations of NE neurons are provided herein. Also provided herein are methods for obtaining genetically modified NE neurons expressing a NE sensor or a TH-reporter, and methods for using NE neurons obtained according to the methods of this disclosure. |
| FILED | Tuesday, December 28, 2021 |
| APPL NO | 17/563844 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0619 (20130101) Original (OR) Class C12N 2500/32 (20130101) C12N 2500/38 (20130101) C12N 2501/13 (20130101) C12N 2501/15 (20130101) C12N 2501/16 (20130101) C12N 2501/415 (20130101) C12N 2501/999 (20130101) C12N 2506/02 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5058 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204926 | Ng et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Hon Man Alex Ng (Cambridge, Massachusetts); Parastoo Khoshakhlagh (Cambridge, Massachusetts); George M. Church (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein is a differentiation agent that consist essentially of SOX9 for the production of oligodendrocyte progenitor cells (OPCs) from pluripotent stem cells (PSCs). Also provided herein are methods of producing the PSCs and methods of using the PSCs to produce OPCs and oligodendrocytes. |
| FILED | Monday, November 29, 2021 |
| APPL NO | 17/536807 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/30 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0622 (20130101) Original (OR) Class C12N 9/1241 (20130101) C12N 15/85 (20130101) C12N 15/90 (20130101) C12N 2501/24 (20130101) C12N 2501/60 (20130101) C12N 2501/231 (20130101) C12N 2506/45 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204927 | MIAO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE GEORGE WASHINGTON UNIVERSITY (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | SHIDA MIAO (Washington, District of Columbia); HAITAO CUI (Washington, District of Columbia); LIJIE GRACE ZHANG (Washington, District of Columbia) |
| ABSTRACT | Disclosed herein is a 4D printed programmable culture substrate with the self-morphing ability to accommodate the change in morphology of stem cells during differentiation. The 4D printed culture substrate includes a shape memory polymer that is configured for transformation from a first topographical shape to a second topographical shape during a predetermined time period in response to a stimulus, such as temperature. The first topographical shape may include micro-wells and the second topographical shape may include microgrooves, which can accommodate the growth and differentiation of neural stem cells. |
| FILED | Wednesday, March 09, 2022 |
| APPL NO | 17/690966 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 80/00 (20141201) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0062 (20130101) C12N 5/0075 (20130101) C12N 5/0623 (20130101) Original (OR) Class C12N 2513/00 (20130101) C12N 2533/30 (20130101) C12N 2537/10 (20130101) C12N 2539/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204938 | KLEMKE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard KLEMKE (La Jolla, California); Huawei WANG (San Diego, California) |
| ABSTRACT | Provided herein are cytoplasts, compositions comprising cytoplasts, methods of using cytoplasts, and methods of treating a subject, such as providing benefits to a healthy or unhealthy subject, or treating or diagnosing a disease or condition in a subject. In some embodiments, methods of treating a subject include: administering to the subject a therapeutically effective amount of a composition comprising a cytoplast. Also, provided herein are compositions (e.g., pharmaceutical compositions) that include a cytoplast. Also, provided herein are kits comprising instructions for using the compositions or methods. |
| FILED | Friday, February 04, 2022 |
| APPL NO | 17/665130 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 35/12 (20130101) A61K 35/28 (20130101) A61K 38/2066 (20130101) A61K 39/215 (20130101) A61K 39/001102 (20180801) A61K 2039/515 (20130101) A61K 2039/545 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0662 (20130101) Original (OR) Class C12N 15/85 (20130101) C12N 2501/999 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204964 | Kaplan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David L. Kaplan (Concord, Massachusetts); Siwei Zhao (Medford, Massachusetts); Fiorenzo G. Omenetto (Lexington, Massachusetts) |
| ABSTRACT | A method of making silk articles including preparing a silk fibroin solution including silk fibroin and microalgae, and introducing the silk fibroin solution into a solvent bath including a crosslinking agent. The method can incorporate 3D printing techniques to allow for easy fabrication of the articles into various forms. The silk articles can provide a cell-friendly matrix that allows 3D encapsulation of microalgae while maintaining normal cell proliferation and functions for an extended period of time. |
| FILED | Wednesday, April 29, 2020 |
| APPL NO | 17/607620 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 70/00 (20141201) B33Y 80/00 (20141201) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/24 (20130101) C08J 3/075 (20130101) C08J 2389/00 (20130101) C08J 2401/28 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 11/04 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 3/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204970 | JOSEPHS |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Greensboro (Greensboro, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric JOSEPHS (Durham, North Carolina) |
| ABSTRACT | Generally, the present disclosure is directed to methods for gRNA design and products thereof that can be used as antivirals in which the produced gRNAs can be tolerant to polymorphisms across clinical strains and/or adapted for activity at multiple viral sites. Aspects of example gRNAs can also include reduced interactions with the human genome or transcriptome. |
| FILED | Monday, December 20, 2021 |
| APPL NO | 17/556481 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/102 (20130101) C12N 15/111 (20130101) Original (OR) Class C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204971 | Nogalski et al. |
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| FUNDED BY |
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| APPLICANT(S) | Icahn School of Medicine at Mount Sinai (New York, New York); The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (New York, New York); The Trustees of Princeton University (Princeton, New Jersey) |
| INVENTOR(S) | Maciej T. Nogalski (Princeton, New Jersey); Alexander Solovyov (New York, New York); Thomas Shenk (Princeton, New Jersey); Benjamin D. Greenbaum (New York, New York) |
| ABSTRACT | The present invention relates to compositions comprising isolated, single stranded RNA molecules and pharmaceutically acceptable carriers suitable for injection. The present invention relates to methods for stimulating an immune response and treating tumors. The present invention further relates to kits comprising a cancer vaccine and compositions of the present invention for use as an adjuvant to cancer vaccines. |
| FILED | Thursday, July 25, 2019 |
| APPL NO | 17/263099 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/113 (20130101) C12N 2310/3231 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204974 | Flotte et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | University of Massachusetts (Boston, Massachusetts) |
| INVENTOR(S) | Terence Flotte (Holden, Massachusetts); Christian Mueller (Concord, Massachusetts); Phillip D. Zamore (Northborough, Massachusetts) |
| ABSTRACT | The invention relates to isolated nucleic acids and rAAV-based compositions, methods and kits useful for treating genetic diseases (e.g., alpha-1 antitrypsin deficiency). |
| FILED | Friday, January 14, 2022 |
| APPL NO | 17/576130 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) A61K 35/12 (20130101) A61K 38/57 (20130101) A61K 48/005 (20130101) A61K 48/0058 (20130101) Peptides C07K 14/8125 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/67 (20130101) C12N 15/86 (20130101) C12N 15/111 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204978 | Yeo et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eugene Yeo (La Jolla, California); Frederick Tan (Encinitas, California) |
| ABSTRACT | Provided herein ar compositions and methods for regulating protein translation. The compositions include a cap-conjugated oligonucleotide comprising an m7G cap or a variant or analog thereof conjugated to an oligonucleotide, wherein the oligonucleotide is capable of specifically hybridizing with a target sequence in an RNA molecule. The disclosure further provides methods of regulating translation of an mRNA in a cell, the method comprising contacting the cell with a cap-conjugated oligonucleotide comprising an m7G cap or a variant or analog thereof conjugated to an oligonucleotide, wherein the oligonucleotide comprises a sequence capable of specifically hybridizing with a target sequence in an RNA molecule. |
| FILED | Thursday, April 16, 2020 |
| APPL NO | 17/604139 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/67 (20130101) Original (OR) Class C12N 15/111 (20130101) C12N 2310/317 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204988 | Grompe et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Oregon Health and Science University (Portland, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Markus Grompe (Portland, Oregon); Sunghee Chai (Portland, Oregon) |
| ABSTRACT | The present disclosure provides ubiquitous short promoter elements capable of driving gene expression in multiple mammalian cell types of medical interest. Expression vectors incorporating the promoters are disclosed herein. Viral vectors, in particular, AAV vectors with capacity for larger transgenes than are possible with conventional promoters are disclosed herein. Methods of enhancing gene expression are disclosed herein. |
| FILED | Friday, April 24, 2020 |
| APPL NO | 17/594501 |
| CURRENT CPC | Peptides C07K 14/62 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 2750/14143 (20130101) C12N 2830/008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220205017 | SCHMITT et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIMA GENOMICS, INC. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anthony SCHMITT (Apex, North Carolina); Siddarth SELVARAJ (San Marcos, California); Bret REID (San Diego, California); Stephen MAC (Baldwin Park, California); Xiang ZHOU (San Diego, California) |
| ABSTRACT | Provided herein are methods and compositions for preparing sequencing templates that provide uniform genome coverage and preserve spatial-proximal contiguity information. |
| FILED | Tuesday, May 19, 2020 |
| APPL NO | 17/610414 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1093 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6874 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220205042 | Salomon et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Scripps Research Institute (La Jolla, California); Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel R. Salomon (San Diego, California); Josh Levitsky (Evanston, Illinois); Sunil Kurian (San Diego, California); Michael Abecassis (Highland Park, Illinois) |
| ABSTRACT | By a genome-wide gene analysis of expression profiles of known or putative gene sequences in peripheral blood and biopsy samples, the present inventors have identified a consensus set of gene expression-based molecular biomarkers for distinguishing liver transplantation patients who have Acute Rejection (AR), Hepatitis C Virus Recurrence (HCV-R), both AR/HCV-R, or Acute Dysfunction No Rejection (ADNR). These molecular biomarkers are useful for diagnosis, prognosis and monitoring of liver transplantation patients. |
| FILED | Friday, August 13, 2021 |
| APPL NO | 17/401643 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2537/165 (20130101) C12Q 2600/106 (20130101) C12Q 2600/112 (20130101) C12Q 2600/118 (20130101) C12Q 2600/136 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5088 (20130101) G01N 2800/245 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/20 (20180101) G16H 20/10 (20180101) G16H 20/17 (20180101) G16H 20/40 (20180101) G16H 40/63 (20180101) G16H 50/20 (20180101) G16H 50/30 (20180101) G16H 50/70 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220205048 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yuxuan Wang (Baltimore, Maryland); Bert Vogelstein (Baltimore, Maryland); Kenneth W. Kinzler (Baltimore, Maryland); Luis Diaz (Ellicot City, Maryland); Nickolas Papadopoulos (Towson, Maryland); Karin Sundfeldt (Gothenburg, Sweden); Bjorg Kristjansdottir (Gothenburg, Sweden) |
| ABSTRACT | A diagnostic test for ovarian cysts is based on the detection of mutations characteristic of the most common neoplasms giving rise to these lesions. With this test, tumor-specific mutations were detected in the cyst fluids of 19 of 24 (79%) borderline tumors and 28 of 31 (90%) malignant ovarian cancers. In contrast, we detected no mutations in the cyst fluids from 10 non-neoplastic cysts and 12 benign tumors. When categorized by the need for exploratory surgery (i.e., presence of a borderline tumor or malignant cancer), the sensitivity of this test was 85% and the specificity was 100%. These tests could inform the diagnosis of ovarian cysts and improve the clinical management of the large number of women with these lesions. |
| FILED | Friday, January 14, 2022 |
| APPL NO | 17/576503 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220205917 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason Liu (Durham, North Carolina); Ashutosh Chilkoti (Durham, North Carolina) |
| ABSTRACT | A microarray chip imaging detector comprises a housing configured to receive a microarray chip. The detector includes a laser assembly supported by the housing and oriented at an angle relative to the microarray chip, the laser assembly configured to transmit an excitation beam along a first axis to samples on the microarray chip. The detector also includes a camera supported by the housing and positioned along a second axis, the camera configured to receive fluorescent light emitted from fluorophores in the samples on the microarray chip, the second axis oriented at an angle less than 30 degrees relative to the first axis. The housing includes a plurality of baffles positioned between the microarray chip and the camera, and a plurality of laser beamstops to receive the excitation beam reflected off the microarray chip. |
| FILED | Saturday, May 02, 2020 |
| APPL NO | 17/607761 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6402 (20130101) G01N 21/6428 (20130101) G01N 21/6452 (20130101) Original (OR) Class G01N 21/6456 (20130101) G01N 2021/6439 (20130101) G01N 2201/022 (20130101) G01N 2201/0642 (20130101) G01N 2201/06113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220205981 | COULOMBE et al. |
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| FUNDED BY |
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| APPLICANT(S) | Brown University (Providence, Rhode Island); Rhode Island Hospital (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kareen L. K. COULOMBE (Pawtucket, Rhode Island); Cassady E. RUPERT (New Haven, Connecticut); Celinda M. KOFRON (Hope, Rhode Island); Bum-Rak CHOI (Warwick, Rhode Island); Taeyun KIM (Coventry, Rhode Island); Ulrike MENDE (Norfolk, Massachusetts) |
| ABSTRACT | The Cardio-Tox Tissue Engineered Model (TEEM) invention provides a robust in vitro model for cardiotoxicity evaluation using three-dimensional (3D) human heart microtissues to quantify dose-dependent changes in electromechanical activity, resulting in a comprehensive cardiotoxicity and arrhythmia risk assessment of test compounds. The invention also provides a predictive in vitro screening platform for pro-arrhythmic toxicity testing using human three-dimensional cardiac microtissues. The invention enables the screening of environmental and pharmaceutical compounds, chemicals, and toxicants to establish safe human exposure levels. |
| FILED | Monday, May 18, 2020 |
| APPL NO | 17/611064 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0697 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/30 (20130101) G01N 21/6428 (20130101) G01N 21/6456 (20130101) G01N 33/5014 (20130101) G01N 33/5088 (20130101) Original (OR) Class G01N 2021/6439 (20130101) G01N 2800/32 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/10064 (20130101) G06T 2207/30024 (20130101) G06T 2207/30048 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220205983 | Zhuang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Xiaowei Zhuang (Cambridge, Massachusetts); Chong Wang (Cambridge, Massachusetts); Tian Lu (Cambridge, Massachusetts) |
| ABSTRACT | The present invention generally relates to imaging cells, for example, to determine phenotypes and/or genotypes in populations of cells, e.g., to build genotype-phenotype corresponse for high-throughput screening. In some cases, the cells may be manipulated, e.g., using CRISPR or other techniques. In certain embodiments, nucleic acids may be introduced to the cell, e.g., using a lentivirus. The nucleic acids may contain a guide portion comprising a DNA or RNA recognition sequence, a reporter portion, and an identification portion comprising one or more read sequences. The guide portion may be used to alter the phenotype of the cells, e.g., using a sequence, e.g., an sgRNA sequence, that can be targeted using CRISPR or other techniques, and in some cases, the phenotype of the cells may be determined using various imaging approaches. The identification portion may be determined using MERFISH or other suitable techniques. In addition, in some cases, association or colocalization between determination of the reporter and the read sequences may substantially improve decoding accuracy, e.g., due to lowered misidentification of background signals. Other aspects are generally directed to compositions or devices for use in such methods, kits for use in such methods, or the like. |
| FILED | Friday, April 17, 2020 |
| APPL NO | 17/604686 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/111 (20130101) C12N 15/113 (20130101) C12N 2310/20 (20170501) C12N 2320/12 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 33/52 (20130101) Original (OR) Class G01N 2021/6439 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220205989 | Swager et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Timothy Manning Swager (Newton, Massachusetts); Hadley Sikes Johnson (Arlington, Massachusetts); Qifan Zhang (Revere, Massachusetts); Eric Alexander Miller (Somerville, Massachusetts); Lukas Zeininger (Berlin, Germany); Ki-Joo Sung (Minneapolis, Minnesota); Kosuke Yoshinaga (Cambridge, Massachusetts) |
| ABSTRACT | Embodiments described herein may be useful in the detection of analytes. The systems and methods may allow for a relatively simple and rapid way for detecting analytes such as chemical and/or biological analytes and may be useful in numerous applications including sensing, food manufacturing, medical diagnostics, performance materials, dynamic lenses, water monitoring, environmental monitoring, detection of proteins, detection of DNA, among other applications. For example, the systems and methods described herein may be used for determining the presence of a contaminant such as bacteria (e.g., detecting pathogenic bacteria in food and water samples which helps to prevent widespread infection, illness, and even death). Advantageously, the systems and methods described herein may not have the drawbacks in current detection technologies including, for example, relatively high costs, long enrichment steps and analysis times, and/or the need for extensive user training. Another advantageous feature provided by the systems and methods described herein includes fabrication in a relatively large scale. In some embodiments, the systems and methods may be used in conjunction with a detector including handheld detectors incorporated with, for example, smartphones (e.g., for the on-site detection of analytes such as pathogenic bacteria). |
| FILED | Wednesday, December 08, 2021 |
| APPL NO | 17/545979 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/701 (20130101) C12Q 1/6834 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/59 (20130101) G01N 21/77 (20130101) G01N 21/78 (20130101) G01N 33/5432 (20130101) Original (OR) Class G01N 33/54366 (20130101) G01N 33/56983 (20130101) G01N 2021/7783 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220206279 | Han et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (Orlando, Florida) |
| ASSIGNEE(S) | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (Orlando, Florida) |
| INVENTOR(S) | Kyu Young Han (Orlando, Florida); Benjamin Croop (Oviedo, Florida); Jialei Tang (San Jose, California) |
| ABSTRACT | A method and associated apparatus for generating instantaneous and uniform total internal reflection fluorescence (TIRF) excitation. An annular fiber bundle and is used with spatially incoherent light to provide appropriate illumination matched to parameters of the back focal plane of an oil-immersion or in-air imaging objective lens, enabling quantitative shadowless TIRF imaging. |
| FILED | Tuesday, December 14, 2021 |
| APPL NO | 17/644278 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6458 (20130101) G01N 2021/6478 (20130101) G01N 2021/6484 (20130101) Optical Elements, Systems, or Apparatus G02B 21/06 (20130101) G02B 21/16 (20130101) Original (OR) Class G02B 21/33 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220207730 | Arnold et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Corey Arnold (Oakland, California); Jiayun Li (Oakland, California); William Speier (Oakland, California); Wenyun Li (Oakland, California) |
| ABSTRACT | In accordance with one aspect of the disclosure, an image analysis system is provided. The image analysis system includes at least one processor configured to access image tiles associated with a patient, each tile comprising a portion of a whole slide image, individually provide a first group of image tiles to a first trained model, receive a first set of feature objects from the first trained model, cluster feature objects from the first set of feature objects to form a number of clusters, calculate a number of attention scores based on the first set of feature objects, select a second group of tiles, individually provide the second group of image tiles to a second trained model, receive a second set of feature objects from the second trained model, generate a cancer grade indicator, and cause the cancer grade indicator to be output. |
| FILED | Tuesday, May 26, 2020 |
| APPL NO | 17/612062 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30024 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 15/00 (20180101) G16H 30/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220207791 | Shi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Luyao Shi (New Haven, Connecticut); Chi Liu (Orange, Connecticut); John Onofrey (Woodbridge, Connecticut); Hui Liu (New Haven, Connecticut) |
| ABSTRACT | A system for estimating attenuation coefficients from only single photon emission computed tomography (SPECT) emission data using deep neural networks includes an artificial neural network based upon machine learning system estimating attenuation maps for SPECT emission data, and associated attenuation correction method. |
| FILED | Friday, April 17, 2020 |
| APPL NO | 17/594364 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Image Data Processing or Generation, in General G06T 11/003 (20130101) Original (OR) Class G06T 2207/10108 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220207902 | Datta et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Sandeep Robert Datta (Cambridge, Massachusetts); Alexander B. Wiltschko (Cambridge, Massachusetts) |
| ABSTRACT | A method for studying the behavior of an animal in an experimental area including stimulating the animal using a stimulus device; collecting data from the animal using a data collection device; analyzing the collected data; and developing a quantitative behavioral primitive from the analyzed data. A system for studying the behavior of an animal in an experimental area including a stimulus device for stimulating the animal; a data collection device for collecting data from the animal; a device for analyzing the collected data; and a device for developing a quantitative behavioral primitive from the analyzed data. A computer implemented method, a computer system and a nontransitory computer readable storage medium related to the same. Also, a method and apparatus for automatically discovering, characterizing and classifying the behavior of an animal in an experimental area. Further, use of a depth camera and/or a touch sensitive device related to the same. |
| FILED | Friday, January 21, 2022 |
| APPL NO | 17/581326 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 29/005 (20130101) A01K 67/00 (20130101) Diagnosis; Surgery; Identification A61B 5/112 (20130101) A61B 5/1116 (20130101) A61B 5/7203 (20130101) A61B 5/7225 (20130101) Image Data Processing or Generation, in General G06T 7/0016 (20130101) G06T 7/20 (20130101) Image or Video Recognition or Understanding G06V 40/10 (20220101) Original (OR) Class G06V 40/20 (20220101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) Pictorial Communication, e.g Television H04N 13/204 (20180501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220208194 | Rameau et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | Cornell University (Ithaca, New York) |
| INVENTOR(S) | Anais Rameau (Ithaca, New York); Simon Dunham (Ithaca, New York); Fei Wang (Ithaca, New York) |
| ABSTRACT | The present disclosure describes approaches to voice restoration using personal devices that detect surface electromyographic (sEMG) signals from articulatory muscles for the recognition of silent speech in a patient (such as a patient with total laryngectomy, on voice rest, etc.). A personal device may comprise a cutaneous sensor unit and a control module that wirelessly transmits signals to a computing device capable of, for example, applying a predictive model to signals to generate text or synthesize speech. Methods and systems for training and applying predictive models, and fabricating personal devices, are disclosed. |
| FILED | Thursday, May 28, 2020 |
| APPL NO | 17/614022 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/015 (20130101) Image Data Processing or Generation, in General G06T 7/64 (20170101) G06T 7/70 (20170101) G06T 2207/30201 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 21/00 (20130101) Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 15/16 (20130101) G10L 15/22 (20130101) G10L 15/24 (20130101) Original (OR) Class G10L 15/063 (20130101) G10L 15/197 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220208303 | Kurtz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | David M. Kurtz (San Francisco, California); Maximilian Diehn (San Carlos, California); Arash Ash Alizadeh (San Mateo, California) |
| ABSTRACT | Processes and materials to detect cancer from a biopsy are described. In some cases, cell-free nucleic acids can be sequenced, and the sequencing result can be utilized to detect sequences derived from a neoplasm. Detection of somatic variants occurring in phase can indicate the presence of cancer in a diagnostic scan and a clinical intervention can be performed. |
| FILED | Wednesday, December 29, 2021 |
| APPL NO | 17/646473 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) C12Q 1/6886 (20130101) C12Q 2600/156 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/20 (20190201) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220208306 | KLATT et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MEMORIAL SLOAN KETTERING CANCER CENTER (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin Gunther KLATT (New York, New York); David A. SCHEINBERG (New York, New York) |
| ABSTRACT | Disclosed herein is an epitope data processing system processes amino acid sequences of a plurality of epitopes determined from a plurality of peptide fragments from a subject. The epitope data processing system identifies a human leukocyte antigen ligand match (HLA-LM) of the epitope by comparing an amino acid sequence of the epitope to an amino acid sequence of at least one unmutated human leukocyte antigen (HLA) ligand, where the HLA-LM binds to at least one HLA allele. The system determines that the epitope is a potentially immunogenic epitope (PIE) based on comparison of % rank of the epitope to the % rank of the HLA-LM for the same HLA allele. The system determines unique epitope-HLA pairs, determines epitope scores, clonality scores, and responder scores for each of the PIES, and ranks the PIEs based on the respective responder scores. |
| FILED | Wednesday, April 29, 2020 |
| APPL NO | 17/607129 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5008 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 30/10 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220208388 | PATEK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (Charlottesville, Virginia) |
| ASSIGNEE(S) | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (Charlottesville, Virginia) |
| INVENTOR(S) | Stephen D. PATEK (Charlottesville, Virginia); Marc D. BRETON (Charlottesville, Virginia) |
| ABSTRACT | A method and system use mathematical models and available patient information to virtualize a continuous glucose monitoring trace for a period of time. Such a method and system can generate the virtualized trace when episodic patient data is incomplete. Such a method and system can also rely on self-monitored blood glucose measurement information to improve the virtualized continuous glucose monitoring trace. |
| FILED | Wednesday, March 16, 2022 |
| APPL NO | 17/696466 |
| CURRENT CPC | Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) G16H 40/63 (20180101) G16H 50/50 (20180101) Original (OR) Class G16H 50/70 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220208538 | Laskin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Julia Laskin (West Lafayette, Indiana); Xiangtang Li (West Lafayette, Indiana); Ruichuan Yin (West Lafayette, Indiana) |
| ABSTRACT | The invention generally relates to mass spectral analysis. In certain embodiments, methods of the invention involve a probe for nano spray desorption electro spray ionization (nano-DESI) with fixed positioning of the channels therein for consistent and stable formation of a liquid bridge for nano-DESI and mass spectrometry imaging (MSI). Probes may incorporate a shear force probe for sensing and maintaining a desired distance between the probe and the sample surface being analyzed. |
| FILED | Friday, May 22, 2020 |
| APPL NO | 17/609114 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 49/142 (20130101) H01J 49/165 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220208540 | Behsaz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bahar Behsaz (Pasadena, California); Liu Cao (Pittsburgh, Pennsylvania); Mustafa Guler (Pittsburgh, Pennsylvania); Yi-Yuan Lee (Ithaca, New York); Hosein Mohimani (Pittsburgh, Pennsylvania) |
| ABSTRACT | A method and system is for searching a database to identify structures of molecular compounds from mass spectrometry data. Operations of the method and system include receiving a query for a target molecular structure in the database, the query representing a query spectrum; accessing a machine learning model trained with molecule-spectrum pairs; inputting the query spectrum into the machine learning model; generating, from the machine learning model, a score for each of one or more molecular structures, each score representing a probability that a molecular structure corresponds to the query spectrum; selecting, based on each of the scores, a small molecule; and outputting, on a user interface, a representation of the small molecule. |
| FILED | Friday, December 17, 2021 |
| APPL NO | 17/554690 |
| CURRENT CPC | Peptides C07K 1/047 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6818 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 40/10 (20190201) Electric Discharge Tubes or Discharge Lamps H01J 49/26 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20220202325 | BASIRI |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Bioxytech Retina, Inc. (Richmond, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ali BASIRI (Pleasant Hill, California) |
| ABSTRACT | A method of determining a parameter related to a blood oxygenation of tissue may include projecting an optical pattern onto the issue, the optical pattern comprising a spatially varying component in at least one axis. A method of determining a parameter related to a blood oxygenation of tissue may include collecting a reflected optical signal from at least a first and a second wavelength range, wherein the first and the second wavelength ranges are distinct. A method of determining a parameter related to a blood oxygenation of tissue may include normalizing the reflected optical signal. A method of determining a parameter related to a blood oxygenation of tissue may include performing a transform of the reflected optical signal. A method of determining a parameter related to a blood oxygenation of tissue may include determining the parameter related to the blood oxygenation of the tissue based on the ratio and the transform. |
| FILED | Thursday, December 31, 2020 |
| APPL NO | 17/139898 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4088 (20130101) A61B 5/7257 (20130101) A61B 5/14555 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/4925 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) G16H 15/00 (20180101) G16H 50/20 (20180101) G16H 50/30 (20180101) G16H 50/50 (20180101) G16H 50/70 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220202489 | Keidar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The George Washington University (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Keidar (Baltimore, Maryland); Xiaoqian Cheng (McLean, Virginia); Alexey Shashurin (West Lafayette, Virginia); Jonathan Sherman (Potomac, Maryland) |
| ABSTRACT | A system and method of treating an area having cancerous cells. The system includes a plasma device to generate a plasma jet directed at the area having cancerous cells. A magnetic field generator generates a magnetic field directed at the area having cancerous cells. A controller is coupled to the plasma device and the magnetic field generator to control the plasma jet generated by the plasma device and control the magnetic field generated by the magnetic field generator. |
| FILED | Wednesday, January 05, 2022 |
| APPL NO | 17/647118 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 18/18 (20130101) Original (OR) Class A61B 18/042 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 47/555 (20170801) A61K 47/6925 (20170801) A61K 48/00 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 2/002 (20130101) A61N 2/06 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220202961 | Achilefu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Samuel Achilefu (St. Louis, Missouri); Nalinikanth Kotagiri (St. Louis, Missouri) |
| ABSTRACT | The present disclosure discloses methods and compositions for administering Cerenkov radiation-induced therapy (CRIT). |
| FILED | Friday, October 01, 2021 |
| APPL NO | 17/449766 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 41/0038 (20130101) A61K 41/0057 (20130101) A61K 49/0013 (20130101) A61K 49/0021 (20130101) A61K 49/0056 (20130101) Original (OR) Class A61K 51/0474 (20130101) A61K 51/0482 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220203307 | Nair et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sankar Nair (Atlanta, Georgia); Shaowei Yang (Atlanta, Georgia); Christopher W. Jones (Atlanta, Georgia); Byunghyun Min (Atlanta, Georgia) |
| ABSTRACT | Disclosed are methods of manufacturing a zeolite membrane, comprising: providing at least one porous substrate; and coating the at least one porous substrate with a membrane. In some embodiments, the method further comprises hydrothermally treating the membrane with a first hydrothermal treatment step with tetrapropylammonium fluoride (TPAF) and a second hydrothermal treatment step with tetraethammonium hydroxide (TEAOH). In some embodiments, coating the substrate with a membrane comprises surrounding at least a portion of the at least one porous substrate with a precursor gel, the gel comprising a gel phase and a plurality of CHA or MFI crystals; heating the at least one porous substrate and the precursor gel; washing the at least one porous substrate; drying the at least one porous substrate; and calcining the at least one porous substrate. |
| FILED | Thursday, April 09, 2020 |
| APPL NO | 17/602490 |
| CURRENT CPC | Separation B01D 53/228 (20130101) B01D 69/12 (20130101) B01D 71/028 (20130101) Original (OR) Class B01D 2257/504 (20130101) B01D 2257/702 (20130101) B01D 2323/08 (20130101) B01D 2323/10 (20130101) B01D 2325/02 (20130101) B01D 2325/04 (20130101) B01D 2325/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220203359 | Chiou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pei Yu E. Chiou (Oakland, California); Kuan-Wen Tung (Oakland, California); Benjamin M. Wu (San Marino, California) |
| ABSTRACT | The present invention relates to a near-field acoustic platform capable of synthesizing high resolution, arbitrarily shaped energy potential wells. A thin and viscoelastic membrane is utilized to modulate acoustic wavefront on a deep, sub-wavelength scale by suppressing the structural vibration selectively on the platform. This new acoustic wavefront modulation mechanism is powerful for manufacturing complex biologic products. |
| FILED | Friday, April 24, 2020 |
| APPL NO | 17/605925 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) Original (OR) Class B01L 3/502761 (20130101) B01L 2300/123 (20130101) B01L 2300/161 (20130101) B01L 2300/1894 (20130101) B01L 2400/0439 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220203576 | Nutt et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven Nutt (Irvine, California); Lessa Grunenfelder (Los Angeles, California); Timotei Centea (Venice, California); Mark Anders (Los Angeles, California); William Thomas Edwards (Fullerton, California); Sarah Grace Katz Schechter (Los Angeles, California) |
| ABSTRACT | Methods, apparatuses, and systems for making prepregs are disclosed. A method may include depositing a resin material onto a surface of a fiber bed and forming a number of discrete resin regions thereon. A distance between the resin regions may be measured to provide desired exposed portions of the surface to facilitate permeation of air through the exposed portions of the surface in a direction perpendicular to a plane of the fiber bed during a curing process of the prepreg. |
| FILED | Tuesday, January 04, 2022 |
| APPL NO | 17/568664 |
| CURRENT CPC | Preparation or Pretreatment of the Material to be Shaped; Making Granules or Preforms; Recovery of Plastics or Other Constituents of Waste Material Containing Plastics B29B 15/122 (20130101) Original (OR) Class Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 70/20 (20130101) B29C 70/443 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2307/04 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204366 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UWM Research Foundation, Inc. (Milwaukee, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Junhong Chen (Chicago, Illinois); Xingkang Huang (Darien, Illinois) |
| ABSTRACT | A water purification system comprising a thiol-functionalized graphene oxide/activated carbon composite material, a filter and one or more capacitive deionization cells with applications in removal of water contaminants such as heavy metal ions without generation of wastewater. |
| FILED | Wednesday, April 22, 2020 |
| APPL NO | 17/605133 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/001 (20130101) C02F 1/4691 (20130101) Original (OR) Class C02F 1/46109 (20130101) C02F 2001/46138 (20130101) C02F 2101/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204401 | Sant et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Los Angeles, California); Arizona Board of Regents on Behalf of Arizona State University (Tempe, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gaurav Sant (Los Angeles, California); Laurent G. Pilon (Los Angeles, California); Bu Wang (Los Angeles, California); Narayanan Neithalath (Chandler, Arizona); Zhenhua Wei (Los Angeles, California); Benjamin Young (Los Angeles, California); Gabriel D. Falzone (Los Angeles, California); Dante Simonetti (Los Angeles, California) |
| ABSTRACT | A manufacturing process of a concrete product includes: (1) extracting calcium from solids as portlandite; (2) forming a cementitious slurry including the portlandite; (3) shaping the cementitious slurry into a structural component; and (4) exposing the structural component to carbon dioxide sourced from a flue gas stream, thereby forming the concrete product. |
| FILED | Wednesday, December 29, 2021 |
| APPL NO | 17/565025 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 7/19 (20130101) Original (OR) Class C04B 7/38 (20130101) C04B 7/46 (20130101) C04B 7/367 (20130101) C04B 9/20 (20130101) C04B 28/04 (20130101) C04B 40/0231 (20130101) C04B 2111/00129 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204447 | Hua |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Kansas State University Research Foundation (Manhattan, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Duy H. Hua (Manhattan, Kansas) |
| ABSTRACT | Chiral polyvinylpyrrolidinone (CSPVP), complexes of CSPVP with a core species, such as a bimetallic nanocluster catalyst, and enantioselective oxidation reactions utilizing such complexes are disclosed. The catalytic complexes have exhibited the ability to achieve reaction products have a very high degree of optical purifies. These reaction products can be used as reagents in the synthesis of complex organic molecules, such as bioactive products, and C—H bond oxidation of complex molecules including various drugs and natural products. |
| FILED | Tuesday, February 04, 2020 |
| APPL NO | 17/428070 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 35/026 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Heterocyclic Compounds C07D 205/08 (20130101) Original (OR) Class C07D 207/28 (20130101) C07D 211/78 (20130101) C07D 305/12 (20130101) C07D 307/33 (20130101) C07D 309/30 (20130101) C07D 471/04 (20130101) C07D 471/22 (20130101) C07D 487/04 (20130101) Steroids C07J 1/00 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 126/10 (20130101) C08F 226/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204480 | ZHU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | New York University (New York, New York) |
| ASSIGNEE(S) | New York University (New York, New York) |
| INVENTOR(S) | Xiaolong ZHU (New York, New York); Jingxiang YANG (New York, New York); Chunhua T. HU (New York, New York); Michael D. WARD (New York, New York); Bart KAHR (Brooklyn, New York) |
| ABSTRACT | The present invention relates to crystalline polymorphs of imidacloprid for effective pest management strategies at lower dosages. The present invention further relates to processes of preparing the crystalline polymorphs, and to methods of controlling pests using the novel crystalline polymorphs. |
| FILED | Friday, December 10, 2021 |
| APPL NO | 17/547456 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 43/50 (20130101) General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/13 (20130101) Heterocyclic Compounds C07D 403/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204773 | Fini et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Elham Fini (Phoenix, Arizona); Albert Hung (Tempe, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elham Fini (Phoenix, Arizona); Albert Hung (Tempe, Arizona) |
| ABSTRACT | Preparing a modified bitumen composition includes combining bitumen with elemental sulfur to yield a mixture, and crystallizing the elemental sulfur on a surface of the bitumen to yield a layer of elemental sulfur on the surface of the bitumen. The mixture typically includes about 5 wt % to about 15 wt % of the elemental sulfur. A modified bitumen composition includes A modified bitumen composition includes bitumen and elemental sulfur on a surface of the bitumen. The modified bitumen composition includes about 5 wt % to about 15 wt % of the elemental sulfur. |
| FILED | Thursday, December 30, 2021 |
| APPL NO | 17/565589 |
| CURRENT CPC | Compositions of Macromolecular Compounds C08L 95/00 (20130101) Original (OR) Class C08L 2555/54 (20130101) C08L 2555/64 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204919 | YOON et al. |
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| FUNDED BY |
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| APPLICANT(S) | The University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Seongkyu YOON (Lowell, Massachusetts); Bingyu KUANG (Worcester, Massachusetts); Duc HOANG (Burnsville, Minnesota) |
| ABSTRACT | A method of cell culture includes (i) culturing cells in a cell culture medium, and (ii) maintaining at least one metabolite below an inhibitory concentration in the cell culture medium for the at least one metabolite, wherein the at least one metabolite is aconitic acid (AA), leucinic acid (HICA), cytidine monophosphate (CMP), methylsuccinic acid (MSA), trigonelline (TRI), N-acetylputrescinium (NAP), or a combination thereof, and wherein the enzyme comprises ADH5, BCAT1, CAT, GOT1, HADHB, HOGA1, SLC35A1, or a combination thereof. |
| FILED | Monday, February 14, 2022 |
| APPL NO | 17/671029 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0025 (20130101) Original (OR) Class C12N 2500/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204925 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Su-Chun Zhang (Waunakee, Wisconsin); Yunlong Tao (Madison, Wisconsin) |
| ABSTRACT | Methods for obtaining populations of norepinephrine (NE) neuronal progenitor cells and creating enriched populations of NE neurons are provided herein. Also provided herein are methods for obtaining genetically modified NE neurons expressing a NE sensor or a TH-reporter, and methods for using NE neurons obtained according to the methods of this disclosure. |
| FILED | Tuesday, December 28, 2021 |
| APPL NO | 17/563844 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0619 (20130101) Original (OR) Class C12N 2500/32 (20130101) C12N 2500/38 (20130101) C12N 2501/13 (20130101) C12N 2501/15 (20130101) C12N 2501/16 (20130101) C12N 2501/415 (20130101) C12N 2501/999 (20130101) C12N 2506/02 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5058 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204927 | MIAO et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE GEORGE WASHINGTON UNIVERSITY (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | SHIDA MIAO (Washington, District of Columbia); HAITAO CUI (Washington, District of Columbia); LIJIE GRACE ZHANG (Washington, District of Columbia) |
| ABSTRACT | Disclosed herein is a 4D printed programmable culture substrate with the self-morphing ability to accommodate the change in morphology of stem cells during differentiation. The 4D printed culture substrate includes a shape memory polymer that is configured for transformation from a first topographical shape to a second topographical shape during a predetermined time period in response to a stimulus, such as temperature. The first topographical shape may include micro-wells and the second topographical shape may include microgrooves, which can accommodate the growth and differentiation of neural stem cells. |
| FILED | Wednesday, March 09, 2022 |
| APPL NO | 17/690966 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 80/00 (20141201) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0062 (20130101) C12N 5/0075 (20130101) C12N 5/0623 (20130101) Original (OR) Class C12N 2513/00 (20130101) C12N 2533/30 (20130101) C12N 2537/10 (20130101) C12N 2539/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204969 | Lynch et al. |
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| FUNDED BY |
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| APPLICANT(S) | DUKE UNIVERSITY (DURHAM, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael David Lynch (Durham, North Carolina); Ashley Delanie Trahan (Hillsborough, North Carolina); Daniel Rodriguez (Durham, North Carolina); Zhixia Ye (Raleigh, North Carolina); Charles Bridwell Cooper (Durham, North Carolina); Ahmet Bozdag (Durham, North Carolina) |
| ABSTRACT | This invention relates to metabolically engineered microorganisms, such as bacterial and or fungal strains, and bioprocesses utilizing such strains. These strains enable the dynamic control of metabolic pathways, which can be used to optimize production. Dynamic control over metabolism is accomplished via a combination of methodologies including but not limited to transcriptional silencing and controlled enzyme proteolysis. These microbial strains are utilized in a multi-stage bioprocess encompassing at least two stages, the first stage in which organisms are grown and metabolism can be optimized for microbial growth and at least one other stage in which growth can be slowed or stopped, and dynamic changes can be made to metabolism to improve the production of desired product, such as a chemical or fuel. |
| FILED | Tuesday, October 05, 2021 |
| APPL NO | 17/494047 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) C12N 15/70 (20130101) C12N 15/111 (20130101) Original (OR) Class C12N 15/1137 (20130101) C12N 2310/14 (20130101) C12N 2320/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204982 | Sayre |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NMC, INC. (Los Alamos, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard Thomas Sayre (Los Alamos, New Mexico) |
| ABSTRACT | Embodiments of the present invention provide for a transgenic plan, methods of making and DNA contructs for use in the transgenic plant which transgenic plant is capable of modulating its photosynthetic antenna complex composition in response to increases or decreases in light intensity by modulation of the ratio of chlorophyll a to chlorophyll b such that there is an increase in the Chl a/b ratio at high light intensity and a decrease in the Chl a/b ratio at low light intensity versus wild-type plants grown in the same conditions. |
| FILED | Tuesday, September 07, 2021 |
| APPL NO | 17/467998 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0073 (20130101) C12N 15/825 (20130101) C12N 15/8222 (20130101) C12N 15/8237 (20130101) Original (OR) Class C12N 15/8245 (20130101) C12N 15/8261 (20130101) C12N 15/8269 (20130101) Enzymes C12Y 114/13122 (20130101) Technologies for Adaptation to Climate Change Y02A 40/146 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204984 | Shanklin et al. |
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| FUNDED BY |
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| APPLICANT(S) | Brookhaven Science Associates, LLC (Upton, New York); The Research Foundation For The State University of New York (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Shanklin (Shoreham, New York); Xioa-Hong Yu (Mount Sinai, New York); Hui Liu (Middle Island, New York); Jantana Keereetaweep (Wading River, New York); Yuanheng Cai (Shirley, New York) |
| ABSTRACT | Compositions that are plants, seeds or crops that have a combination of defective BADC genes and genes for making hydroxy fatty acids produced normal levels of oil containing specialty fatty acids, and exhibited an increases in total oil accumulation, increase in absolute hydroxy (specialized) fatty acid accumulation per seed and/or per plant and/or per unit land area. Defective BADC genes and genes for synthesizing hydroxy fatty acids are combined to produce specialized fatty acids without substantially slowing production of endogenous fatty acids. Methods are also described for increasing production of unusual fatty acids and increasing total fatty acid levels in plants by a mechanism involving combining defective BADC genes and genes for making hydroxy fatty acids to produce steady or increased levels of oil containing the increased specialty products as described herein. |
| FILED | Wednesday, November 24, 2021 |
| APPL NO | 17/534993 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8247 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204996 | Redding et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Kevin Redding (Tempe, Arizona); Andrey Kanygin (Phoenix, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin Redding (Tempe, Arizona); Andrey Kanygin (Phoenix, Arizona) |
| ABSTRACT | Provided herein, in some embodiments, are engineered cells and use of the same for increased hydrogen production. In particular, provided herein are genetically engineered cells comprising a polynucleotide encoding a fusion protein comprising a photosystem I (PSI) protein and an algal hydrogenase, as well as methods for producing such genetically engineered cells. Also provided herein are methods for increasing hydrogen (H2) production in cells. |
| FILED | Thursday, December 30, 2021 |
| APPL NO | 17/565684 |
| CURRENT CPC | Peptides C07K 14/405 (20130101) C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/12 (20130101) C12N 9/0077 (20130101) C12N 15/62 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 3/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220205930 | Klein |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Boulder Environmental Sciences and Technology (Boulder, Colorado) |
| ASSIGNEE(S) | Boulder Environmental Sciences and Technology (Boulder, Colorado) |
| INVENTOR(S) | Marian Klein (Boulder, Colorado) |
| ABSTRACT | A system for passive microwave remote sensing using at least one microwave radiometer includes a fixed body portion and a mobile body portion. The mobile body portion is configured for rotatably coupling with the fixed body portion for rotation about a rotation axis. The mobile body portion is configured for supporting the microwave radiometer therein such that the microwave radiometer rotates about the rotation axis when the mobile body portion is rotated about the rotation axis such that a polarization axis of the radiometer is aligned with an earth axis. The fixed body portion includes a motor mechanism for effecting rotation of the mobile body portion. In an embodiment, the mobile body portion includes a plurality of body section, each body section being configured for supporting a microwave radiometer therein. In another embodiment, each one of the plurality of body sections is configured to be interchangeably coupled with each other. |
| FILED | Wednesday, December 30, 2020 |
| APPL NO | 17/138268 |
| CURRENT CPC | Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 11/006 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 22/04 (20130101) Original (OR) Class Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags G01V 3/17 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220206020 | ABBOTT et al. |
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| FUNDED BY |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | CORNELL UNIVERSITY (Ithaca, None) |
| INVENTOR(S) | Nicholas ABBOTT (Ithaca, New York); Karthik NAYANI (Ithaca, New York) |
| ABSTRACT | The response of biological cells to applied stress is central to the functioning of living systems. The present disclosure is directed to systems, compositions and methods for rapidly reporting biomechanical properties of cells or cellular organelles at a single cell or population level. |
| FILED | Friday, April 24, 2020 |
| APPL NO | 17/605792 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 19/061 (20130101) C09K 19/3402 (20130101) C09K 19/3819 (20130101) C09K 2019/3425 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/36 (20130101) G01N 33/80 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/10056 (20130101) G06T 2207/30024 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220206092 | NOTAROS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Colorado State University Research Foundation (Fort Collins, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | BRANISLAV NOTAROS (Fort Collins, Colorado); Milan ILIC (Belgrade, None) |
| ABSTRACT | The exemplary system and method facilitate excitation of RF magnetic fields in ultra-high field (UHF) magnetic resonance (MRI) systems (e.g., MRI/NMR system) using a slotted waveguide array (SWGA) as an exciter coil. The exemplary exciter coil, in some embodiments, is configurable to provide RF magnetic field B1+ with high field-uniformity, with high efficiency, with excellent circular polarization, with negligible axial z-component, with arbitrary large field of view, and with exceptional possibilities for field-optimizations via RF shimming. |
| FILED | Tuesday, March 15, 2022 |
| APPL NO | 17/694907 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/343 (20130101) G01R 33/345 (20130101) G01R 33/365 (20130101) G01R 33/3678 (20130101) Original (OR) Class G01R 33/3808 (20130101) G01R 33/5611 (20130101) G01R 33/34092 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220206205 | RUBIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Noah A. RUBIN (Cambridge, Massachusetts); Federico CAPASSO (Cambridge, Massachusetts) |
| ABSTRACT | An optical component includes a substrate and a metasurface comprising one or more linearly birefringent elements. The linearly birefringent elements define a grating configured to implement parallel polarization analysis for a plurality of polarization orders for incident light of an arbitrary polarization. |
| FILED | Tuesday, April 14, 2020 |
| APPL NO | 17/603574 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 4/04 (20130101) Optical Elements, Systems, or Apparatus G02B 1/002 (20130101) G02B 5/1833 (20130101) G02B 5/3083 (20130101) Original (OR) Class G02B 27/4261 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220206358 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| ASSIGNEE(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| INVENTOR(S) | Mo Li (Minneapolis, Minnesota); Huan Li (Minneapolis, Minnesota); Qiyu Liu (Minneapolis, Minnesota) |
| ABSTRACT | The present disclosure provides an acousto-optic device comprising an acousto-optic layer, an electromagnetic radiation source, and an acoustic source. In an embodiment, the acousto-optic layer has a substantially planar shape defining an x-y plane and functions as an optical waveguide to optical waves and as an acoustic waveguide to acoustic waves propagating in the x-y plane. In an embodiment, the electromagnetic radiation source is optically coupled to the acousto-optic layer and configured to deliver electromagnetic radiation therein. In an embodiment, the acoustic source is acoustically coupled to the acousto-optic layer and configured to deliver acoustic energy therein and is configured to adjust a wavelength of the acoustic energy. In an embodiment, the electromagnetic radiation source and the acoustic energy source are positioned to provide an intersection between the electromagnetic radiation and the acoustic energy, which at least partially scatters light from the intersection out of the x-y plane. |
| FILED | Friday, April 10, 2020 |
| APPL NO | 17/602415 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/4817 (20130101) G01S 17/02 (20130101) Optical Elements, Systems, or Apparatus G02B 26/0858 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/335 (20130101) Original (OR) Class Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220206434 | Ozcan et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Aydogan Ozcan (Los Angeles, California); Yair Rivenson (Los Angeles, California); Tairan Liu (Los Angeles, California); Yibo Zhang (Los Angeles, California); Zhensong Wei (Los Angeles, California) |
| ABSTRACT | A method for performing color image reconstruction of a single super-resolved holographic sample image includes obtaining a plurality of sub-pixel shifted lower resolution hologram images of the sample using an image sensor by simultaneous illumination at multiple color channels. Super-resolved hologram intensity images for each color channel are digitally generated based on the lower resolution hologram images. The super-resolved hologram intensity images for each color channel are back propagated to an object plane with image processing software to generate a real and imaginary input images of the sample for each color channel. A trained deep neural network is provided and is executed by image processing software using one or more processors of a computing device and configured to receive the real input image and the imaginary input image of the sample for each color channel and generate a color output image of the sample. |
| FILED | Tuesday, April 21, 2020 |
| APPL NO | 17/604416 |
| CURRENT CPC | Holographic Processes or Apparatus G03H 1/0443 (20130101) G03H 1/0808 (20130101) G03H 1/0866 (20130101) Original (OR) Class G03H 1/2645 (20130101) G03H 2001/005 (20130101) Computer Systems Based on Specific Computational Models G06N 3/084 (20130101) G06N 3/0454 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220207171 | Moataz |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MongoDB, Inc. (New York, New York) |
| ASSIGNEE(S) | MongoDB, Inc. (New York, New York) |
| INVENTOR(S) | Tarik Moataz (North Providence, Rhode Island) |
| ABSTRACT | Methods and system implement solutions for integrating encryption and emulation into native database formats and/or architectures. “Native” database is used to describe a database that has not been designed for end to end encryption, an off the shelf database deployment, and/or a commercially available database. According to some embodiments, various encryption systems and methods employ emulation operations to enable a native database and native database functions to leverage full encryption primitives. Various aspects integrate emulation operations into standard database implementations, where the emulation enables native database functions to operate on entirely encrypted data. |
| FILED | Tuesday, December 28, 2021 |
| APPL NO | 17/563425 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/248 (20190101) G06F 16/24573 (20190101) G06F 21/53 (20130101) G06F 21/602 (20130101) G06F 21/6227 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220207272 | Siskind et al. |
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| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Jeffrey Mark Siskind (West Lafayette, Indiana); Haonan Yu (Sunnyval, California) |
| ABSTRACT | A system and method for determining the locations and types of objects in a plurality of videos. The method comprises pairing each video with one or more sentences describing the activity or activities in which those objects participate in the associated video, wherein no use is made of a pretrained object detector. The object locations are specified as rectangles, the object types are specified as nouns, and sentences describe the relative positions and motions of the objects in the videos referred to by the nouns in the sentences. The relative positions and motions of the objects in the video are described by a conjunction of predicates constructed to represent the activity described by the sentences associated with the videos. |
| FILED | Tuesday, December 29, 2020 |
| APPL NO | 17/135995 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00718 (20130101) Original (OR) Class G06K 9/6215 (20130101) G06K 9/6296 (20130101) Image Data Processing or Generation, in General G06T 7/20 (20130101) G06T 7/73 (20170101) G06T 2207/10016 (20130101) G06T 2207/10024 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220207761 | NARASIMHAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Srinivasa NARASIMHAN (Pittsburgh, Pennsylvania); Joseph BARTELS (Pittsburgh, Pennsylvania); William L. WHITTAKER (Pittsburgh, Pennsylvania); Jian WANG (Pittsburgh, Pennsylvania) |
| ABSTRACT | A method to dynamically and adaptively sample the depths of a scene using the principle of triangulation light curtains is described. The approach directly detects the presence or absence of obstacles (or scene points) at specified 3D lines in a scene by sampling the scene. The scene can be sampled sparsely, non-uniformly, or densely at specified regions. The depth sampling can be varied in real-time, enabling quick object discovery or detailed exploration of areas of interest. Once an object is discovered in the scene, adaptive light curtains comprising dense sampling of a region of the scene containing the object, can be used to better define the position, shape and size of the discovered object. |
| FILED | Wednesday, September 25, 2019 |
| APPL NO | 17/601780 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 11/2513 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 17/48 (20130101) G01S 17/89 (20130101) Image Data Processing or Generation, in General G06T 7/521 (20170101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220208204 | Sivaraman Narayanaswamy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of Arizona State University (Tempe, Florida) |
| ASSIGNEE(S) | Lawrence Livermore National Security, LLC (Livermore, California); Arizona Board of Regents on Behalf of Arizona State University (Tempe, Arizona) |
| INVENTOR(S) | Vivek Sivaraman Narayanaswamy (Tempe, Arizona); Jayaraman Thiagarajan (Dublin, California); Rushil Anirudh (San Francisco, California); Andreas Spanias (Tempe, Arizona) |
| ABSTRACT | Various embodiments of a system and associated method for audio source separation based on generative priors trained on individual sources. Through the use of projected gradient descent optimization, the present approach simultaneously searches in the source-specific latent spaces to effectively recover the constituent sources. Though the generative priors can be defined in the time domain directly, it was found that using spectral domain loss functions leads to good-quality source estimates. |
| FILED | Wednesday, December 29, 2021 |
| APPL NO | 17/564502 |
| CURRENT CPC | Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 21/028 (20130101) Original (OR) Class G10L 25/18 (20130101) G10L 25/30 (20130101) Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 29/008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220208410 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); Samsung Electronics Co., Ltd. (Suwon-si, South Korea) |
| INVENTOR(S) | Ju Li (Weston, Massachusetts); Andrea Maurano (Somerville, Massachusetts); Yuming Chen (Cambridge, Massachusetts); Ziqiang WANG (Cambridge, Massachusetts); So Yeon Kim (Cambridge, Massachusetts) |
| ABSTRACT | A mixed ionic-electronic conductor (MIEC) in contact with a solid electrolyte includes a material having a bandgap less than 3 eV. The material includes an end-member phase directly connected to an alkali metal by a tie-line in an equilibrium phase diagram. The material is thermodynamically stable with a solid electrolyte. The MIEC includes plurality of open pores, formed within the MIEC, to facilitate motion of the alkali metal to at least one of store the alkali metal in the plurality of open pores or release the alkali metal from the plurality of open pores. The solid electrolyte has an ionic conductivity to ions of the alkali metal greater than 1 mS cm−1, a thickness less than 100 μm, and comprises at least one of a ceramic or a polymer. |
| FILED | Monday, March 14, 2022 |
| APPL NO | 17/694174 |
| CURRENT CPC | Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/02 (20130101) Original (OR) Class H01B 1/06 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/485 (20130101) H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 10/0565 (20130101) H01M 2300/0082 (20130101) H01M 2300/0085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220208539 | BADU-TAWIAH et al. |
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| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Abraham BADU-TAWIAH (Columbus, Ohio); Dmytro KULYK (Columbus, Ohio) |
| ABSTRACT | Disclosed herein are methods and systems for ionizing organic compounds by exposing head space vapors to corona discharge. The methods and systems are suitable for high throughput screening of samples, including biofluids. The methods and systems are suitable for rapid evaluation of chemical reactions, permitting discovery of novel organic reaction pathways. |
| FILED | Wednesday, April 29, 2020 |
| APPL NO | 17/607521 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 49/0031 (20130101) H01J 49/167 (20130101) Original (OR) Class H01J 49/168 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220208644 | Grayson |
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| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Grayson (Evanston, Illinois) |
| ABSTRACT | Systems and/or methods can provide for solid-state refrigeration below 1 degree Kelvin. By applying a simple sequence of ac electrical signals to a gated semiconductor device, electrons are cooled in a refrigeration sequence that, in turn, provides cooling directly to the heat load of interest. Electrons in a single subband of a semiconductor quantum well are expanded adiabatically into several subbands, resulting in a temperature drop. Repeated application of this cycle at MHz-GHz frequencies results in a significant cooling power. The anticipated cooling powers can compete with today's standard cryogenic system, the dilution refrigerator, which represents the market standard for achieving cryogenic temperatures. |
| FILED | Friday, May 01, 2020 |
| APPL NO | 17/607823 |
| CURRENT CPC | Refrigeration Machines, Plants or Systems; Combined Heating and Refrigeration Systems; Heat-pump Systems F25B 1/00 (20130101) F25B 21/00 (20130101) F25B 2321/003 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/3738 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220209091 | ZHANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF NOTRE DAME DU LAC (South Bend, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yanliang ZHANG (South Bend, Indiana); Mortaza Saeidi-Javash (South Bend, Indiana) |
| ABSTRACT | Methods, ink compositions, and 3D conformal printed flexible films. The method may include aerosol jet printing a thermoelectric ink composition, followed by photonic or other sintering of the ink to remove surfactant included therein, and to convert the thermoelectric nanoparticles of the ink composition into a dense structure capable of charge carrier transport. The ink compositions may be solution-processed semimetal-chalcogenides (e.g., Te containing materials) in a suitable carrier (e.g., polyol(s), alcohol(s), etc.). A surfactant (e.g., PVP) may be present in the ink. Within seconds of photonic sintering, the electrical conductivity of the printed film is dramatically increased from non-conductive to a value on the order of at least 1×104 S/m. The films may demonstrate a room-temperature power factor of at least 500 μWm−1K−2. The realized values of 730-2200 μWm−1K−2 achieved are among the highest values reported for flexible thermoelectric films. The film is durable (e.g., 500 bending cycles with no significant performance drop). |
| FILED | Monday, June 08, 2020 |
| APPL NO | 17/609159 |
| CURRENT CPC | Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 7/61 (20180101) C09D 7/66 (20180101) C09D 11/36 (20130101) C09D 11/38 (20130101) C09D 11/52 (20130101) C09D 11/322 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 35/16 (20130101) Original (OR) Class H01L 35/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220209293 | Hersam et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark C. Hersam (Wilmette, Illinois); Woo Jin Hyun (Evanston, Illinois) |
| ABSTRACT | This invention discloses high-modulus, ion-conductive gel electrolytes and methods of making the gel electrolytes and electrochemical devices. The gel electrolytes include an ionic liquid and nanosheets mixed in the ionic liquid. The nanosheets in one example include exfoliated hexagonal boron nitride (hBN) nanosheets. Compared to conventional bulk hBN microparticles, exfoliated hBN nanosheets improve the mechanical properties of the gel electrolytes by about 2 orders of magnitude, while retaining high ionic conductivity at room temperature. Moreover, exfoliated hBN nanosheets are compatible with high-voltage cathodes, and impart exceptional thermal stability that allows high-rate operation of solid-state rechargeable lithium-ion batteries at high temperatures. |
| FILED | Monday, May 18, 2020 |
| APPL NO | 17/613166 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/382 (20130101) H01M 4/485 (20130101) H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 4/583 (20130101) H01M 10/0525 (20130101) H01M 10/0565 (20130101) Original (OR) Class H01M 2300/0082 (20130101) H01M 2300/0085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220209310 | Ergen et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Onur Ergen (Berkeley, California); Alexander K. Zettl (Kensington, California) |
| ABSTRACT | This disclosure provides systems, methods, and apparatus related to Li-ion batteries. In one aspect an electrolyte structure for use in a battery comprises an electrolyte and an interconnected boron nitride structure disposed in the electrolyte. |
| FILED | Tuesday, January 11, 2022 |
| APPL NO | 17/573488 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/056 (20130101) H01M 10/0525 (20130101) H01M 10/4235 (20130101) Original (OR) Class H01M 2300/0025 (20130101) H01M 2300/0045 (20130101) H01M 2300/0071 (20130101) H01M 2300/0085 (20130101) H01M 2300/0091 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220209844 | JAMIESON et al. |
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| FUNDED BY |
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| APPLICANT(S) | Kyle JAMIESON (Princeton, New Jersey); Minsung KIM (Princeton, New Jersey); Davide VENTURELLI (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kyle JAMIESON (Princeton, New Jersey); Minsung KIM (Princeton, New Jersey); Davide VENTURELLI (San Francisco, California) |
| ABSTRACT | Systems and methods herein provide for Multi-Input/Multi-Output (MIMO) processing. In one embodiment, a MIMO system comprises a receiver operable to receive a plurality of spatially multiplexed data streams. The system also comprises a processor operable to embed a maximum likelihood (ML) detection algorithm onto a quantum annealer, and to decode the spatially multiplexed data streams via the embedded ML to detect data bits of a plurality of users. |
| FILED | Monday, May 11, 2020 |
| APPL NO | 17/606947 |
| CURRENT CPC | Transmission H04B 7/043 (20130101) H04B 7/0452 (20130101) H04B 7/0617 (20130101) H04B 7/0854 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 1/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20220202849 | KEHN-HALL et al. |
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| FUNDED BY |
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| APPLICANT(S) | George Mason University (Fairfax, Virginia) |
| ASSIGNEE(S) | George Mason University (Fairfax, Virginia) |
| INVENTOR(S) | Kylene Wesley KEHN-HALL (Blacksburg, Virginia); Bibha DAHAL (Silver Spring, Maryland); Jonathan DINMAN (Potomac, Maryland); Jonathan Larson Jacobs (Rockville, Maryland) |
| ABSTRACT | The present disclosure provides compositions and methods for modulating PERK activity and/or expression in cells for use in treatment or prevention of viral infection, including by reducing translation of viral non-structural proteins in cells using compositions and/or compounds that inhibit PERK activity and/or expression. |
| FILED | Friday, October 08, 2021 |
| APPL NO | 17/497187 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7105 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/12 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220202964 | Cui et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| INVENTOR(S) | Lina Cui (Gainesville, Florida); Kelton Schleyer (Gainesville, Florida); Jun Liu (Gainesville, Florida) |
| ABSTRACT | The invention relates to compounds that interact with heparanase, uses in heparanase screening, uses in in vitro and in vivo imaging (e g , positron emission tomography (PET) and magnetic resonance imaging (MRI)), methods of synthesis, methods of modulating heparanase activity, and methods of treating disease and disorders associated with heparanase. The compounds of the invention are also useful in treating one or more diseases or disorders associated with the function of heparanase. |
| FILED | Thursday, April 23, 2020 |
| APPL NO | 17/605144 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 6/037 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 49/085 (20130101) A61K 49/106 (20130101) A61K 49/108 (20130101) A61K 51/0491 (20130101) Original (OR) Class Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 17/075 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/40 (20130101) Enzymes C12Y 302/01166 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220203099 | Muller et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Nia Therapeutics, Inc. (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rikky Muller (San Francisco, California); Benjamin Johnson (Boise, Idaho); Igor Izyumin (Oakland, California) |
| ABSTRACT | Representative methods, apparatus and systems are disclosed for providing concurrent electrical stimulation and electrical recording in a human or non-human subject, such as for neuromodulation, with the apparatus coupleable to an electrode array. A representative apparatus is typically an integrated circuit including: stimulation circuits, recording circuits, and blocking circuits responsive to control signals to block the stimulation voltage or current on an electrode from a corresponding recording circuit, while other recording circuits may simultaneously record electrical signals from other electrodes and generate recorded data. A representative stimulation circuit may include current sources; a first multiplexer for current source selection; a second multiplexer for electrode selection; a switchable voltage offset circuit; a switchable grounding circuit; and a stimulation controller providing control signals to provide the electrical stimulation, such as biphasic or monophasic stimulation, and bipolar or unipolar stimulation. Off-chip communication, control, along with power and voltage level control, are also provided. |
| FILED | Wednesday, March 16, 2022 |
| APPL NO | 17/696182 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/291 (20210101) A61B 5/4094 (20130101) A61B 5/4836 (20130101) A61B 5/6868 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/36125 (20130101) A61N 1/36139 (20130101) A61N 1/36157 (20130101) Original (OR) Class A61N 1/36167 (20130101) A61N 1/37223 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 1/00 (20130101) H02J 7/00 (20130101) H02J 7/0063 (20130101) H02J 50/20 (20160201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220203437 | Morgan et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Eric Morgan (Bolton, Massachusetts); Andrew Whitehead (Somerville, Massachusetts) |
| ABSTRACT | The reaction between aluminum metal and water holds promise for producing hydrogen; however, solid aluminum metal is difficult to manage and use, and the reactivity between aluminum and water is often difficult to control. Certain embodiments of the disclosure are related to a water-stable aluminum slurry comprising a plurality of activated aluminum particles dispersed in a fluid carrier. In some embodiments, the reactivity of the aluminum slurry in the presence of water may be easily controlled with the addition of various additives (e.g., surfactants). Additionally, methods of making and using the water-stable aluminum slurry to controllable manage the reactivity between aluminum and water are presented herein. |
| FILED | Friday, October 22, 2021 |
| APPL NO | 17/508324 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/0088 (20130101) Original (OR) Class B22F 2001/0092 (20130101) B22F 2301/052 (20130101) Non-metallic Elements; Compounds Thereof; C01B 3/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204146 | Ripplinger et al. |
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| FUNDED BY |
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| APPLICANT(S) | Battle Sight Technologies, LLC (Dayton, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas R. Ripplinger (Springboro, Ohio); Christopher J. Vogt (Cincinnati, Ohio) |
| ABSTRACT | An apparatus that facilitates search and rescue, for example, in open water. The apparatus comprises a substrate with a particular geometry and a perimeter. The apparatus further comprises a cover positioned atop the substrate with the cover also having a particular geometry and perimeter, which correspond to the geometry and perimeter of the substrate. An air-tight seal seals the substrate perimeter to the cover perimeter and creates a sealed internal region. A breakable vessel holding an activator is located in the sealed internal region, along with illuminable dyes that are also located in the sealed internal region. When the breakable vessel is broken, the activator reacts with the illuminable dyes and illuminates the illuminable dyes. |
| FILED | Thursday, March 17, 2022 |
| APPL NO | 17/697335 |
| CURRENT CPC | Launching, Hauling-out, or Dry-docking of Vessels; Life-saving in Water; Equipment for Dwelling or Working Under Water; Means for Salvaging or Searching for Underwater Objects B63C 9/20 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204562 | Kumar-Singh |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rajendra Kumar-Singh (Medford, Massachusetts) |
| ABSTRACT | Cell penetrating peptides that target many cells types including cells of the retina and cornea with high efficiency are provided herein. These peptides can be used to deliver cargo molecules across a plasma membrane, without the need for chemical conjugation. Compositions and viral vectors comprising these cell-penetrating peptides are also provided. Methods of using the peptides, compositions and viruses to deliver various agents to target cells and tissues are also provided. |
| FILED | Thursday, December 30, 2021 |
| APPL NO | 17/646496 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 47/42 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) Peptides C07K 7/06 (20130101) C07K 7/08 (20130101) Original (OR) Class C07K 14/47 (20130101) C07K 14/49 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204779 | Mahn et al. |
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| FUNDED BY |
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| APPLICANT(S) | SWIMC LLC (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edmund J. Mahn (Grove City, Ohio); Mark E. Walker (Tinley Park, Illinois); Mark J. Wytiaz (Chicago, None) |
| ABSTRACT | A low reflectance powder coated article comprising a substrate having thereon a low gloss acrylic powder coating made from: (a) a first acrylic powder resin having a hydroxyl value of at least about 180; (b) a second acrylic powder resin having a hydroxyl value between about 45 and about 80; (c) a crosslinker reactive with the hydroxyl functional acrylic resins; and (d) an acicular filler. |
| FILED | Thursday, September 16, 2021 |
| APPL NO | 17/477072 |
| CURRENT CPC | Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/035 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204945 | Clement et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| INVENTOR(S) | Nathalie Clement (Gainesville, Florida); Barry John Byrne (Gainesville, Florida); Laura Adamson (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein are methods of improving rAAV production in cells, the method comprising increasing the salt concentration in the media in which the cells are infected or transfected, cultured, or in which they produce AAV. Aspects of the disclosure relate to improved methods of rAAV production by co-infecting suspension adapted cells (e.g., suspension adapted HEK293 cells) with viruses that encode one or more AAV components for producing rAAV particles within the suspension adapted cells. |
| FILED | Tuesday, December 07, 2021 |
| APPL NO | 17/544418 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class C12N 15/86 (20130101) C12N 2710/16644 (20130101) C12N 2750/14151 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204969 | Lynch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DUKE UNIVERSITY (DURHAM, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael David Lynch (Durham, North Carolina); Ashley Delanie Trahan (Hillsborough, North Carolina); Daniel Rodriguez (Durham, North Carolina); Zhixia Ye (Raleigh, North Carolina); Charles Bridwell Cooper (Durham, North Carolina); Ahmet Bozdag (Durham, North Carolina) |
| ABSTRACT | This invention relates to metabolically engineered microorganisms, such as bacterial and or fungal strains, and bioprocesses utilizing such strains. These strains enable the dynamic control of metabolic pathways, which can be used to optimize production. Dynamic control over metabolism is accomplished via a combination of methodologies including but not limited to transcriptional silencing and controlled enzyme proteolysis. These microbial strains are utilized in a multi-stage bioprocess encompassing at least two stages, the first stage in which organisms are grown and metabolism can be optimized for microbial growth and at least one other stage in which growth can be slowed or stopped, and dynamic changes can be made to metabolism to improve the production of desired product, such as a chemical or fuel. |
| FILED | Tuesday, October 05, 2021 |
| APPL NO | 17/494047 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) C12N 15/70 (20130101) C12N 15/111 (20130101) Original (OR) Class C12N 15/1137 (20130101) C12N 2310/14 (20130101) C12N 2320/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220205030 | THOMAS |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. (BETHESDA, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rasmi THOMAS (Silver Spring, Maryland) |
| ABSTRACT | Provided are methods for predicting effectiveness of vaccine against HIV or SIV. Provided herein also are methods for predicting protective immunity in a subject, comprising detecting expression levels of multiple genes or gene products, wherein the multiple genes have been identified as a differentially expressed gene set associated with protective immunity against HIV or SIV; calculating a first composite gene expression score (GES) for the differentially expressed gene set; and calculating an average second composite GES for the differentially expressed gene set in biological samples from subjects that have been vaccinated with a candidate vaccine and are not immune to the virus, wherein a first composite GES that is greater than the average second composite GES indicates the effectiveness of the vaccine and that the subject has protective immunity. Also provided are kits for predicting effectiveness of HIV or SIV vaccine and for predicting protective immunity following vaccination. |
| FILED | Tuesday, February 11, 2020 |
| APPL NO | 17/429698 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6851 (20130101) Original (OR) Class C12Q 1/6876 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220205119 | HUANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Yu HUANG (Los Angeles, California); Chungsuk CHOI (Los Angeles, California); Xiangfeng DUAN (Los Angeles, California) |
| ABSTRACT | Electrochemical catalysts for the reduction of CO2 to hydrocarbons, such as ethylene, include Cu nanowires, wherein the Cu nanowires include a stepped surface. |
| FILED | Tuesday, December 28, 2021 |
| APPL NO | 17/564050 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 3/03 (20210101) C25B 3/26 (20210101) C25B 11/075 (20210101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220205166 | Hinton et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DREXEL UNIVERSITY (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | DREXEL UNIVERSITY (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Zachary R. Hinton (Philadelphia, Pennsylvania); Nicolas Javier Alvarez (Drexel Hill, Pennsylvania); Giuseppe Raffaello Palmese (Hainesport, New Jersey) |
| ABSTRACT | Typical commercial surface treatments for continuous carbon fibers are often unavailable for discontinuous fibers. As such, there is little variety of chopped fiber surfaces leading to non-ideal coating solutions which result in poor interfacial compatibility between fibers and a composite matrix. A method of applying a highly effective coating using a high throughput technique for chopped carbon fibers. The method provides the ability to tune both the coating thickness and chemical functionality using processing parameters. The coatings are evaluated using X-ray photoelectron spectroscopy (XPS) for uniformity and composition. Using this technique, thermoplastic composites are highlighted showing an increase in interfacial shear strength (IFSS) of 25 MPa. This process shows promise for increasing the throughput of surface treatment of chopped fiber on the industrial scale. |
| FILED | Tuesday, February 11, 2020 |
| APPL NO | 17/429860 |
| CURRENT CPC | Treatment, Not Provided for Elsewhere in Class D06, of Fibres, Threads, Yarns, Fabrics, Feathers or Fibrous Goods Made From Such Materials D06M 15/643 (20130101) Original (OR) Class D06M 23/06 (20130101) D06M 2101/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220205840 | GAUME et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (Orlando, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Romain GAUME (Orlando, Florida); Matthew JULIAN (Merritt Island, Florida); Matthieu BAUDELET (Orlando, Florida) |
| ABSTRACT | A method for fabricating an optical source for calibrating an optical system is provided. The method includes determining a form factor for an optical source based on a point of detection of an optical system corresponding to a region where an optical signal of the optical system interacts with a sample. The method also includes providing an envelope in a size and shape to fit the form factor. The method also includes providing a plurality of electrodes connected to the envelope for connection to a power source and filling the envelope with a gas. The optical source formed from the above method is also provided. |
| FILED | Monday, June 03, 2019 |
| APPL NO | 16/429423 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/0297 (20130101) Original (OR) Class G01J 3/443 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/65 (20130101) G01N 21/718 (20130101) G01N 2201/12784 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220206020 | ABBOTT et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | CORNELL UNIVERSITY (Ithaca, None) |
| INVENTOR(S) | Nicholas ABBOTT (Ithaca, New York); Karthik NAYANI (Ithaca, New York) |
| ABSTRACT | The response of biological cells to applied stress is central to the functioning of living systems. The present disclosure is directed to systems, compositions and methods for rapidly reporting biomechanical properties of cells or cellular organelles at a single cell or population level. |
| FILED | Friday, April 24, 2020 |
| APPL NO | 17/605792 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 19/061 (20130101) C09K 19/3402 (20130101) C09K 19/3819 (20130101) C09K 2019/3425 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/36 (20130101) G01N 33/80 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/10056 (20130101) G06T 2207/30024 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220206128 | Hopper et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | WOOLPERT, INC. (Dayton, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nathan Lee Hopper (Diamondhead, Mississippi); Joseph R. Seppi (McLean, Virginia); Rodney Ross Faulkner, II (Diamondhead, Mississippi); Mark Douglas Smits, II (Diamondhead, Mississippi); Joong Yong Park (Slidell, Louisiana); Mark Stephen Millman (Anacortes, Washington); Eric Josef Cahoon (Woodbridge, Virginia); Christopher T. Cotton (Honeoye Falls, New York); Joshua Gluckman (Columbia, Maryland); Alexander Cheff Halterman (San Diego, California); Grady Tuell (Madison, Georgia); Andrew Wallace Stark (New Orleans, Louisiana); John Henry Gerhard (Littleton, Colorado); William Jeffrey Lillycrop (Gulf Breeze, Florida) |
| ABSTRACT | Airborne LiDAR bathymetry systems and methods of use are provided. The airborne LiDAR bathymetry system can collect topographic data and bathymetric data at high altitudes. The airborne LiDAR bathymetry system has a receiver system, a detector system, and a laser transmission system. |
| FILED | Monday, September 20, 2021 |
| APPL NO | 17/479199 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 39/02 (20130101) B64C 2201/123 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/51 (20130101) Original (OR) Class G01S 7/4808 (20130101) G01S 7/4816 (20130101) G01S 7/4863 (20130101) G01S 17/89 (20130101) G01S 2205/03 (20200501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220206186 | CHEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Wei-Ting CHEN (Cambridge, Massachusetts); Federico CAPASSO (Cambridge, Massachusetts); Kerolos M. A. YOUSEF (Giza, Egypt); Yousef A. IBRAHIM (Waterdown, Canada) |
| ABSTRACT | An optical device includes a substrate, a single-layer metasurface disposed on the substrate, and a refractive lens. The metasurface and the refractive lens may be configured to bring at least five distinct wavelengths to focus on a same plane. |
| FILED | Tuesday, April 14, 2020 |
| APPL NO | 17/603904 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 1/002 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220206359 | SCHMITT et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | HAMR Industries LLC (State College, Pennsylvania) |
| ASSIGNEE(S) | HAMR Industries LLC (State College, Pennsylvania) |
| INVENTOR(S) | Michael P. SCHMITT (Houston, Texas); Douglas E. WOLFE (State College, Pennsylvania) |
| ABSTRACT | An optical filter includes a substrate; a first mirror on the substrate; a cavity layer on the first mirror; and a second mirror on the cavity layer. Each of the first and second mirrors provide high reflection, low transmission and low absorption over a targeted stopband. The cavity layer defines a resonant transmission band within the targeted stopband with the resonant band wavelength depending on the optical thickness of the cavity layer. The cavity layer includes a material having a non-linear response to incident irradiance such that cavity absorption changes with irradiance and suppresses cavity resonance at high irradiance. The material having the non-linear response to the incident irradiance includes a two-dimensional (2D) material. |
| FILED | Wednesday, December 29, 2021 |
| APPL NO | 17/564302 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/3503 (20210101) G02F 1/3523 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220206751 | Jain et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafauette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Shubham Jain (West Lafayette, Indiana); Anand Raghunathan (West Lafayette, Indiana); Sumeet Kumar Gupta (West Lafayette, Indiana) |
| ABSTRACT | A circuit of cells used as a memory array and capable of in-memory arithmetic is disclosed which includes a plurality of signed ternary processing, each signed ternary processing cell includes a first memory cell, adapted to hold a first digital value, a second memory cell, adapted to hold a second digital value, wherein a binary combination of the first digital value and the second digital value establishes a first signed ternary operand, a signed ternary input forming a second signed ternary operand, and a signed ternary output, wherein the signed ternary output represents a signed multiplication of the first signed ternary operand and the second signed ternary operand, a sense circuit adapted to output a subtraction result. |
| FILED | Sunday, January 30, 2022 |
| APPL NO | 17/588311 |
| CURRENT CPC | Electric Digital Data Processing G06F 7/523 (20130101) Original (OR) Class G06F 17/16 (20130101) Computer Systems Based on Specific Computational Models G06N 3/063 (20130101) Static Stores G11C 11/412 (20130101) G11C 11/418 (20130101) G11C 11/419 (20130101) G11C 15/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220206937 | Windh et al. |
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| FUNDED BY |
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| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Skyler Arron Windh (McKinney, Texas); Randall Meyer (Allen, Texas) |
| ABSTRACT | Latency in a node-based compute-near-memory system can be problematic. A solution to the problem can include or use a dedicated software-based cache at each node. The cache can be configured to store information received from each of the other nodes in the system. In an example, the cache can be populated during a breadth first search algorithm to store frontier information from each of the other nodes. |
| FILED | Tuesday, June 29, 2021 |
| APPL NO | 17/361691 |
| CURRENT CPC | Electric Digital Data Processing G06F 12/084 (20130101) G06F 12/0246 (20130101) Original (OR) Class G06F 12/0868 (20130101) G06F 12/0893 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220206955 | Keppel |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Pardo Keppel (Mountain View, California) |
| ABSTRACT | A translation lookaside buffer (TLB) having a fixed sub-TLB and a configurable sub-TLB and methods of using the TLB are provided. The TLB includes a fixed sub-TLB and a configurable sub-TLB. The fixed sub-TLB, during runtime, may store a first plurality of TLB entries corresponding to a first page size set. The configurable sub-TLB, during runtime, is configurable to store a second plurality of TLB entries of a second page size set. The second page size set includes at least a first page size of the first page size set and includes at least a second page size not of the first page size set. |
| FILED | Saturday, December 26, 2020 |
| APPL NO | 17/134392 |
| CURRENT CPC | Electric Digital Data Processing G06F 12/1036 (20130101) Original (OR) Class G06F 12/1054 (20130101) G06F 12/1063 (20130101) G06F 2212/304 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220207137 | Huang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Heqing Huang (Mahwah, New Jersey); Taesung Lee (Ridgefield, Connecticut); Ian M. Molloy (Chappaqua, New York); Zhongshu Gu (Ridgewood, New Jersey); Jialong Zhang (White Plains, New York); Josyula R. Rao (Ossining, New York) |
| ABSTRACT | Mechanisms are provided for detecting abnormal system call sequences in a monitored computing environment. The mechanisms receive, from a computing system resource of the monitored computing environment, a system call of an observed system call sequence for evaluation. A trained recurrent neural network (RNN), trained to predict system call sequences, processes the system call to generate a prediction of a subsequent system call in a predicted system call sequence. Abnormal call sequence logic compares the subsequent system call in the predicted system call sequence to an observed system call in the observed system call sequence and identifies a difference between the predicted system call sequence and the observed system call sequence based on results of the comparing. The abnormal call sequence logic generates an alert notification in response to identifying the difference. |
| FILED | Monday, March 14, 2022 |
| APPL NO | 17/693860 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/554 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220207207 | Mirzendehdel et al. |
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| FUNDED BY |
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| APPLICANT(S) | Palo Alto Research Center Incorporated (Palo Alto, California) |
| ASSIGNEE(S) | Palo Alto Research Center Incorporated (Palo Alto, California) |
| INVENTOR(S) | Amirmassoud Mirzendehdel (San Mateo, California); Morad Behandish (Mountain View, California); Saigopal Nelaturi (Mountain View, California) |
| ABSTRACT | A method of classifying design criteria includes receiving design criteria for a product part. The criteria comprise one or both of performance and manufacturing criteria. The design criteria are sorted into different classes of one or both of one or more objective functions and one or more constraints based on when they can be satisfied or optimized. Constraint violations are determined. A design workflow is produced to generate one or more designs of a part to comply with one or more of satisfying constraints and optimizing objective functions. |
| FILED | Wednesday, February 09, 2022 |
| APPL NO | 17/668211 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/17 (20200101) Original (OR) Class G06F 2111/04 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220207272 | Siskind et al. |
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| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Jeffrey Mark Siskind (West Lafayette, Indiana); Haonan Yu (Sunnyval, California) |
| ABSTRACT | A system and method for determining the locations and types of objects in a plurality of videos. The method comprises pairing each video with one or more sentences describing the activity or activities in which those objects participate in the associated video, wherein no use is made of a pretrained object detector. The object locations are specified as rectangles, the object types are specified as nouns, and sentences describe the relative positions and motions of the objects in the videos referred to by the nouns in the sentences. The relative positions and motions of the objects in the video are described by a conjunction of predicates constructed to represent the activity described by the sentences associated with the videos. |
| FILED | Tuesday, December 29, 2020 |
| APPL NO | 17/135995 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00718 (20130101) Original (OR) Class G06K 9/6215 (20130101) G06K 9/6296 (20130101) Image Data Processing or Generation, in General G06T 7/20 (20130101) G06T 7/73 (20170101) G06T 2207/10016 (20130101) G06T 2207/10024 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220207761 | NARASIMHAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Srinivasa NARASIMHAN (Pittsburgh, Pennsylvania); Joseph BARTELS (Pittsburgh, Pennsylvania); William L. WHITTAKER (Pittsburgh, Pennsylvania); Jian WANG (Pittsburgh, Pennsylvania) |
| ABSTRACT | A method to dynamically and adaptively sample the depths of a scene using the principle of triangulation light curtains is described. The approach directly detects the presence or absence of obstacles (or scene points) at specified 3D lines in a scene by sampling the scene. The scene can be sampled sparsely, non-uniformly, or densely at specified regions. The depth sampling can be varied in real-time, enabling quick object discovery or detailed exploration of areas of interest. Once an object is discovered in the scene, adaptive light curtains comprising dense sampling of a region of the scene containing the object, can be used to better define the position, shape and size of the discovered object. |
| FILED | Wednesday, September 25, 2019 |
| APPL NO | 17/601780 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 11/2513 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 17/48 (20130101) G01S 17/89 (20130101) Image Data Processing or Generation, in General G06T 7/521 (20170101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220208241 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jian-Ping Wang (Shoreview, Minnesota); Delin Zhang (Saint Paul, Minnesota); Protyush Sahu (Minneapolis, Minnesota) |
| ABSTRACT | A magnetic device includes a layer stack comprising a first ferromagnetic layer; a spacer layer on the first ferromagnetic layer; a second ferromagnetic layer on the spacer layer; a dielectric barrier layer on the second ferromagnetic layer; an insertion layer positioned between the second ferromagnetic layer and the dielectric barrier layer; and a fixed layer or an electrode on the dielectric barrier layer. In some examples, a magnetic orientation of the second ferromagnetic layer is switched by a bias voltage across the layer stack without application of an external magnetic field; an antiferromagnetic coupling of the first and second ferromagnetic layers is increased by the bias voltage applying a negative charge to the fixed layer or the electrode, and the antiferromagnetic coupling of the first and second ferromagnetic layers is decreased by the bias voltage applying a positive charge to the fixed layer or the electrode. |
| FILED | Thursday, October 14, 2021 |
| APPL NO | 17/450852 |
| CURRENT CPC | Static Stores G11C 11/18 (20130101) G11C 11/161 (20130101) Original (OR) Class G11C 11/1673 (20130101) G11C 11/1675 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/222 (20130101) H01L 43/04 (20130101) H01L 43/06 (20130101) H01L 43/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220208421 | Gulian et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Chapman University (Orange, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Armen Gulian (Ashton, Maryland); Rajendra Dulal (Burtonsville, Maryland); Yasushi Kawashima (Tokyo, Japan); Serafim Teknowijoyo (Burtonsville, Maryland); Sara Chahid (Laurel, Maryland) |
| ABSTRACT | Systems, methods, and apparatus for generating an ideal diamagnetic response are disclosed. A disclosed diamagnetic system includes a metal foil or a first substrate having at least one surface that is coated by a metallic layer (e.g., permalloy). The diamagnetic system also includes a second substrate having at least one surface that is coated by graphene. The first and second substrates are immersed in an alkane (e.g., n-heptane). The diamagnetic system produces a diamagnetic response at room temperature in an applied magnetic field when the alkane is added to surround the permalloy and graphene. |
| FILED | Friday, March 19, 2021 |
| APPL NO | 17/206441 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/06 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 1/0018 (20130101) Original (OR) Class H01F 10/14 (20130101) H01F 10/28 (20130101) H01F 10/30 (20130101) H01F 41/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220209015 | Park |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jisung Park (Ithaca, New York) |
| ABSTRACT | Micron scale tin oxide-based semiconductor devices are provided. Reactive-ion etching is used to produce a micron-scale electronic device using semiconductor films with tin oxides, such as barium stannate (BaSnO3). The electronic devices produced with this approach have high mobility, drain current, and on-off ratio without adversely affecting qualities of the tin oxide semiconductor, such as resistivity, electron or hole mobility, and surface roughness. In this manner, electronic devices, such as field-effect transistors (e.g., thin-film transistors (TFTs)), are produced having micron scale channel lengths and exhibiting complete depletion at room temperature. |
| FILED | Tuesday, January 04, 2022 |
| APPL NO | 17/568372 |
| CURRENT CPC | Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 19/02 (20130101) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/4682 (20130101) C04B 2235/3293 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/3065 (20130101) H01L 21/31144 (20130101) H01L 29/24 (20130101) H01L 29/45 (20130101) H01L 29/517 (20130101) H01L 29/4966 (20130101) H01L 29/7869 (20130101) Original (OR) Class H01L 51/0018 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220209028 | Teague et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph D. Teague (Tijeras, New Mexico); Katherine A. Sheets (Englewood, Ohio) |
| ABSTRACT | A PCSS comprises a photoconductive semiconductor block that exhibits electrically-conductive behavior when exposed to light of a predetermined wavelength; two or more electrodes fixed to the photoconductive semiconductor block and connectable to a power supply; a resonance cavity enveloping the photoconductive semiconductor block, the resonance cavity having a reflective outer surface to trap light within the resonance cavity and the photoconductive semiconductor block, the resonance cavity having a window through the reflective outer surface to admit light of the predetermined wavelength, the resonance cavity being transmissive to light of the predetermined wavelength within the reflective outer surface; and a light source directed toward the photoconductive semiconductor block and through the window, and emitting light at the predetermined wavelength. The photoconductive semiconductor block may include Si, GaAs, GaN, AlN, SiC, and/or Ga2O3. The resonance cavity may include glass, crystal, Au, Ag, Cr, Ni, V, Pd, Pt, Ir, Rh, and/or Al. |
| FILED | Tuesday, December 29, 2020 |
| APPL NO | 17/136516 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/09 (20130101) H01L 31/02325 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220209029 | Mann et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James M. Mann (Springboro, Ohio); Thomas A. Bowen (Beavercreek, Ohio) |
| ABSTRACT | Disclosed is a method for synthesizing single crystalline molybdenum disulfide via a hydrothermal process that minimizes or eliminates carbon byproducts. The method involves providing two components, including a source of molybdenum and a mineralizer solution, to an inert reaction vessel, heating one zone sufficiently to dissolve the source of molybdenum in the mineralizer solution, and heating a second zone to a lower temperature to allow thermal transport to drive the dissolved material to the second zone, and then precipitate MoS2 on a seed crystal. |
| FILED | Thursday, December 31, 2020 |
| APPL NO | 17/139090 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/09 (20130101) H01L 31/02325 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220209090 | Savoy et al. |
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| FUNDED BY |
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| APPLICANT(S) | Nanohmics, Inc. (Austin, Texas) |
| ASSIGNEE(S) | Nanohmics, Inc. (Austin, Texas) |
| INVENTOR(S) | Steve M. Savoy (Austin, Texas); Giri Joshi (Austin, Texas); Michael McAleer (Austin, Texas); Rey Guzman (Austin, Texas); Scott Smith (Lago Vista, Texas); Robert Pearsall (Austin, Texas); Joshua C. Ruedin (Austin, Texas) |
| ABSTRACT | Thermoelectric devices have an electrically conductive connector for connecting thermoelectric modules. The electrically conductive connector is a compliant mechanism having a first connecting region and a second connecting region that are rigid bodies and an elastically deformable region that is a flexible member positioned between the first and second connecting regions. The electrically conductive compliant mechanism connector enables facile manufacture and assembly of thermoelectric devices of various sizes and shapes that are conformable to irregularly shaped objects and body parts. |
| FILED | Thursday, December 23, 2021 |
| APPL NO | 17/561002 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 25/04 (20130101) H01L 35/10 (20130101) Original (OR) Class H01L 35/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220209091 | ZHANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF NOTRE DAME DU LAC (South Bend, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yanliang ZHANG (South Bend, Indiana); Mortaza Saeidi-Javash (South Bend, Indiana) |
| ABSTRACT | Methods, ink compositions, and 3D conformal printed flexible films. The method may include aerosol jet printing a thermoelectric ink composition, followed by photonic or other sintering of the ink to remove surfactant included therein, and to convert the thermoelectric nanoparticles of the ink composition into a dense structure capable of charge carrier transport. The ink compositions may be solution-processed semimetal-chalcogenides (e.g., Te containing materials) in a suitable carrier (e.g., polyol(s), alcohol(s), etc.). A surfactant (e.g., PVP) may be present in the ink. Within seconds of photonic sintering, the electrical conductivity of the printed film is dramatically increased from non-conductive to a value on the order of at least 1×104 S/m. The films may demonstrate a room-temperature power factor of at least 500 μWm−1K−2. The realized values of 730-2200 μWm−1K−2 achieved are among the highest values reported for flexible thermoelectric films. The film is durable (e.g., 500 bending cycles with no significant performance drop). |
| FILED | Monday, June 08, 2020 |
| APPL NO | 17/609159 |
| CURRENT CPC | Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 7/61 (20180101) C09D 7/66 (20180101) C09D 11/36 (20130101) C09D 11/38 (20130101) C09D 11/52 (20130101) C09D 11/322 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 35/16 (20130101) Original (OR) Class H01L 35/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220209286 | Johnson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Scooter David Johnson (Hyattsville, Maryland); Alexander C. Kozen (Mount Ranier, Maryland) |
| ABSTRACT | A method of: forming an aerosol of a powder comprising one or more of lithium, germanium, phosphorus, sulfur, boron, fluorine, chlorine, bromine, aluminum, nitrogen, arsenic, niobium, titanium, vanadium, molybdenum, manganese, zinc, hafnium, and nickel and directing the aerosol at a substrate at a velocity that forms a film of the powder on the substrate. The method makes an article having an ionic conductor in the form of a film at most 0.5 mm thick. |
| FILED | Wednesday, December 29, 2021 |
| APPL NO | 17/565429 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0525 (20130101) H01M 10/0562 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220209310 | Ergen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Onur Ergen (Berkeley, California); Alexander K. Zettl (Kensington, California) |
| ABSTRACT | This disclosure provides systems, methods, and apparatus related to Li-ion batteries. In one aspect an electrolyte structure for use in a battery comprises an electrolyte and an interconnected boron nitride structure disposed in the electrolyte. |
| FILED | Tuesday, January 11, 2022 |
| APPL NO | 17/573488 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/056 (20130101) H01M 10/0525 (20130101) H01M 10/4235 (20130101) Original (OR) Class H01M 2300/0025 (20130101) H01M 2300/0045 (20130101) H01M 2300/0071 (20130101) H01M 2300/0085 (20130101) H01M 2300/0091 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20220203135 | Sampayan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California); Opcondys, Inc. (Manteca, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen E. Sampayan (Manteca, California); Kristin Cortella Sampayan (Manteca, California); George James Caporaso (East Quogue, New York); Yu-Jiuan Chen (Fremont, California); Clifford C. Shang (Livermore, California) |
| ABSTRACT | Methods, devices and systems for ultra-high dose radiotherapy are disclosed. The described techniques rely in-part on active switching control of a photoconductive switch during the time the accelerator is accelerating charged particles to produce the output radiation at the desired dose rates. One flash radiotherapy system includes an induction accelerator, and a controllable switch coupled to the induction accelerator. The switch is operable to produce a plurality of voltage pulses to drive the induction accelerator. The radiotherapy system also includes a radiation measurement device to measure output radiation produced by the radiotherapy system and provide feedback to the controllable switch. The controllable switch is operable to, based on the received feedback, modify an amplitude, shape, spacing, number or width of the voltage pulses that are supplied to the particle accelerator to deliver the desired output radiation. |
| FILED | Wednesday, December 22, 2021 |
| APPL NO | 17/559776 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/1067 (20130101) A61N 5/1071 (20130101) Original (OR) Class A61N 5/1077 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220203335 | Shakouri et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of South Carolina (Columbia, South Carolina) |
| ASSIGNEE(S) | University of South Carolina (Columbia, South Carolina) |
| INVENTOR(S) | Abolfazl Shakouri (Columbia, South Carolina); Horie Adabi Firouzjaie (Columbia, South Carolina); John R. Regalbuto (Columbia, South Carolina); Christopher T. Williams (Columbia, South Carolina); William E. Mustain (Blythewood, South Carolina) |
| ABSTRACT | Described herein is a general scalable synthesis method for a high density of single metal atoms in a supported catalyst, supported isolated atoms featuring unique reactivity and the support materials determine the stability, electronic properties, and local environment which can be adjusted for targeted heterogeneous catalysis applications. |
| FILED | Monday, November 01, 2021 |
| APPL NO | 17/515700 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/18 (20130101) B01J 23/42 (20130101) Original (OR) Class B01J 37/04 (20130101) B01J 37/08 (20130101) B01J 37/0018 (20130101) B01J 37/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220203407 | Kumar et al. |
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| FUNDED BY |
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| APPLICANT(S) | Sortera Alloys, Inc. (Fort Worth, Texas) |
| ASSIGNEE(S) | Sortera Alloys, Inc. (Fort Worth, Texas) |
| INVENTOR(S) | Nalin Kumar (Fort Worth, Texas); Manuel Gerardo Garcia, JR. (Fort Wayne, Indiana) |
| ABSTRACT | Systems and methods for classifying and sorting materials in order to produce a collection of materials that are composed of a particular chemical composition in the aggregate. The system may utilize a vision system and one or more sensor systems, which may implement a machine learning system in order to identify or classify each of the materials. The sorting is then performed as a function of the classifications. |
| FILED | Wednesday, March 16, 2022 |
| APPL NO | 17/696831 |
| CURRENT CPC | Postal Sorting; Sorting Individual Articles, or Bulk Material Fit to be Sorted Piece-meal, e.g by Picking B07C 5/04 (20130101) B07C 5/34 (20130101) B07C 5/342 (20130101) B07C 5/3422 (20130101) Original (OR) Class B07C 2501/0054 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204899 | LIN |
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| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | YuPo J. LIN (Naperville, Illinois) |
| ABSTRACT | A system for biological methane production and removing carbon dioxide from the methane comprises (a) a primary anaerobic digester adapted and arranged to generate a gaseous mixture comprising methane and carbon dioxide from organic materials; (b) an electrochemical reactor comprising at least one reactor cell including an anode spaced from a cathode by a porous ion exchange resin wafer with a cation exchange membrane between the anode and the resin wafer and a bipolar ion exchange membrane between the cathode and the resin wafer; the electrochemical reactor being adapted and arranged to capture gaseous carbon dioxide within the resin wafer as aqueous bicarbonate, and to electrochemically generate hydrogen gas at the cathode; and (c) a hydrogenotrophic methanogenesis bioreactor adapted and arranged to convert the bicarbonate and hydrogen from the electrochemical reactor to methane. An electrochemical reactor and a method for producing methane with reduced carbon dioxide content also are described. |
| FILED | Wednesday, December 30, 2020 |
| APPL NO | 17/137956 |
| CURRENT CPC | Separation B01D 53/185 (20130101) B01D 53/326 (20130101) B01D 2053/221 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204982 | Sayre |
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| FUNDED BY |
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| APPLICANT(S) | NMC, INC. (Los Alamos, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard Thomas Sayre (Los Alamos, New Mexico) |
| ABSTRACT | Embodiments of the present invention provide for a transgenic plan, methods of making and DNA contructs for use in the transgenic plant which transgenic plant is capable of modulating its photosynthetic antenna complex composition in response to increases or decreases in light intensity by modulation of the ratio of chlorophyll a to chlorophyll b such that there is an increase in the Chl a/b ratio at high light intensity and a decrease in the Chl a/b ratio at low light intensity versus wild-type plants grown in the same conditions. |
| FILED | Tuesday, September 07, 2021 |
| APPL NO | 17/467998 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0073 (20130101) C12N 15/825 (20130101) C12N 15/8222 (20130101) C12N 15/8237 (20130101) Original (OR) Class C12N 15/8245 (20130101) C12N 15/8261 (20130101) C12N 15/8269 (20130101) Enzymes C12Y 114/13122 (20130101) Technologies for Adaptation to Climate Change Y02A 40/146 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204984 | Shanklin et al. |
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| FUNDED BY |
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| APPLICANT(S) | Brookhaven Science Associates, LLC (Upton, New York); The Research Foundation For The State University of New York (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Shanklin (Shoreham, New York); Xioa-Hong Yu (Mount Sinai, New York); Hui Liu (Middle Island, New York); Jantana Keereetaweep (Wading River, New York); Yuanheng Cai (Shirley, New York) |
| ABSTRACT | Compositions that are plants, seeds or crops that have a combination of defective BADC genes and genes for making hydroxy fatty acids produced normal levels of oil containing specialty fatty acids, and exhibited an increases in total oil accumulation, increase in absolute hydroxy (specialized) fatty acid accumulation per seed and/or per plant and/or per unit land area. Defective BADC genes and genes for synthesizing hydroxy fatty acids are combined to produce specialized fatty acids without substantially slowing production of endogenous fatty acids. Methods are also described for increasing production of unusual fatty acids and increasing total fatty acid levels in plants by a mechanism involving combining defective BADC genes and genes for making hydroxy fatty acids to produce steady or increased levels of oil containing the increased specialty products as described herein. |
| FILED | Wednesday, November 24, 2021 |
| APPL NO | 17/534993 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8247 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204998 | YU et al. |
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| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado); Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jianping YU (Golden, Colorado); Bo WANG (Nashville, Tennessee) |
| ABSTRACT | Presented herein are Synechococcus strains engineered to express the bacterial ethylene-forming enzyme (EFE) that exhibit unstable ethylene production due to toxicity and genomic instability induced by accumulation of the EFE-byproduct guanidine. Co-expression of EFE and Sll1077 significantly enhanced genomic stability and enabled the resulting Synechococcus strain GD-EFE7942 to achieve sustained high-level ethylene production. The engineered strains and methods disclosed herein are useful for guanidine degradation pathways and for ethylene bioproduction in cyanobacteria. |
| FILED | Friday, December 17, 2021 |
| APPL NO | 17/555350 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/205 (20210501) C12N 15/52 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/065 (20130101) Original (OR) Class Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/01 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220205008 | Arlow et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Daniel Arlow (Berkeley, California); Sebastian Palluk (Berkeley, California) |
| ABSTRACT | Provided herein, among other things, is a conjugate comprising a polymerase and a nucleoside triphosphate, where the polymerase and the nucleoside triphosphate are covalently linked via a linker that comprises a cleavable linkage. A set of such conjugates, where the conjugates correspond to G, A, T (or U) and C is also provided. Methods for synthesizing a nucleic acid of a defined sequence are also provided. The conjugates can also be used for sequencing applications. |
| FILED | Sunday, January 09, 2022 |
| APPL NO | 17/571529 |
| CURRENT CPC | Peptides C07K 19/00 (20130101) C07K 2319/21 (20130101) C07K 2319/24 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1241 (20130101) C12N 9/1252 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) C12Q 1/6874 (20130101) C12Q 1/6876 (20130101) Enzymes C12Y 207/07 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220205363 | Hafner et al. |
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| FUNDED BY |
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| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Troy Hafner (Honea Path, South Carolina); Brad Wilson VanTassel (Easley, South Carolina); Christopher Donald Porter (Greenville, South Carolina); Srikanth Chandrudu Kottilingam (Greenville, South Carolina) |
| ABSTRACT | A coolant delivery system for a component of a gas turbine system includes: a plurality of independent circuits of cooling channels embedded within an exterior wall of the component, each independent circuit of cooling channels including a plurality of headers and a plurality of feed tubes fluidly coupling the plurality of headers to a supply of cooling fluid; and an impingement plate connected to the exterior wall of the component by the plurality of feed tubes of the independent circuits of cooling channels, wherein, in each of the plurality of independent circuits of cooling channels, the cooling fluid flows through the plurality of feed tubes and the plurality of headers into the circuit of cooling channels only in response to a formation of a breach in the exterior wall of the component that exposes at least one of the cooling channels of the circuit of cooling channels. |
| FILED | Friday, October 25, 2019 |
| APPL NO | 16/663873 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/187 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220205838 | Williams |
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| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian P. Williams (Oak Ridge, Tennessee) |
| ABSTRACT | A system and method with AC coupling that reserves photodiode bandwidth in a biased configuration, allows optimal transimpedance amplifier performance, retains DC signal measurement capability, and does not introduce noise into the balanced detection signal. |
| FILED | Monday, September 13, 2021 |
| APPL NO | 17/472869 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 1/18 (20130101) Original (OR) Class G01J 1/4228 (20130101) G01J 2001/446 (20130101) Electric Digital Data Processing G06F 7/588 (20130101) Electric Heating; Electric Lighting Not Otherwise Provided for H05B 47/11 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220205930 | Klein |
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| FUNDED BY |
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| APPLICANT(S) | Boulder Environmental Sciences and Technology (Boulder, Colorado) |
| ASSIGNEE(S) | Boulder Environmental Sciences and Technology (Boulder, Colorado) |
| INVENTOR(S) | Marian Klein (Boulder, Colorado) |
| ABSTRACT | A system for passive microwave remote sensing using at least one microwave radiometer includes a fixed body portion and a mobile body portion. The mobile body portion is configured for rotatably coupling with the fixed body portion for rotation about a rotation axis. The mobile body portion is configured for supporting the microwave radiometer therein such that the microwave radiometer rotates about the rotation axis when the mobile body portion is rotated about the rotation axis such that a polarization axis of the radiometer is aligned with an earth axis. The fixed body portion includes a motor mechanism for effecting rotation of the mobile body portion. In an embodiment, the mobile body portion includes a plurality of body section, each body section being configured for supporting a microwave radiometer therein. In another embodiment, each one of the plurality of body sections is configured to be interchangeably coupled with each other. |
| FILED | Wednesday, December 30, 2020 |
| APPL NO | 17/138268 |
| CURRENT CPC | Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 11/006 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 22/04 (20130101) Original (OR) Class Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags G01V 3/17 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220206075 | STEINGART et al. |
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| FUNDED BY |
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| APPLICANT(S) | FEASIBLE, INC. (EMERYVILLE, California); The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel STEINGART (Princeton, New Jersey); Greg DAVIES (Plainsboro, New Jersey); Shaurjo BISWAS (El Cerrito, California); Andrew HSIEH (Berkeley, California); Barry VAN TASSELL (El Cerrito, California); Thomas HODSON (Princeton, New Jersey); Shan DOU (Berkeley, California) |
| ABSTRACT | Systems and methods for prediction of state of charge (SOH), state of health (SOC) and other characteristics of batteries using acoustic signals, includes determining acoustic data at two or more states of charge and determining a reduced acoustic data set representative of the acoustic data at the two or more states of charge. The reduced acoustic data set includes time of flight (TOF) shift, total signal amplitude, or other data points related to the states of charge. Machine learning models use at least the reduced acoustic dataset in conjunction with non-acoustic data such as voltage and temperature for predicting the characteristics of any other independent battery. |
| FILED | Monday, December 06, 2021 |
| APPL NO | 17/457711 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/07 (20130101) G01N 29/11 (20130101) G01N 29/12 (20130101) G01N 29/043 (20130101) G01N 29/46 (20130101) G01N 29/48 (20130101) G01N 29/50 (20130101) G01N 29/4418 (20130101) G01N 29/4436 (20130101) G01N 29/4481 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 31/385 (20190101) Original (OR) Class G01R 31/392 (20190101) G01R 31/3835 (20190101) Computer Systems Based on Specific Computational Models G06N 5/046 (20130101) G06N 20/00 (20190101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/425 (20130101) H01M 10/486 (20130101) H01M 10/4285 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220206169 | DEGTIARENKO et al. |
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| FUNDED BY |
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| APPLICANT(S) | JEFFERSON SCIENCE ASSOCIATES, LLC (Newport News, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | PAVEL V. DEGTIARENKO (Williamsburg, Virginia); IGOR MUSATOV (SUFFOLK, Virginia) |
| ABSTRACT | A particle imaging method for distinguishing between types of incident particles, such as neutrons, photons, and alphas, and improving the position resolution of particle imaging devices with matrix readout. The method includes high frequency multisampling readout electronics that provides the sequences of multiple measurements for each detected event, resulting in recorded detailed waveform information describing the signals. Such detailed information is used to approximate each signal waveform with a parameterized function in which the extracted parameter sets determine the type of the incident particle in an optimized fashion. The detailed event-by-event multisampling information for each signal readout channel in the matrix readout of the radiation imaging devices improves and optimizes the position resolution for variable shapes of the signals. Such devices can be used in mixed radiation fields, creating a new class of multimodal photon and neutron imagers. |
| FILED | Monday, November 29, 2021 |
| APPL NO | 17/536490 |
| CURRENT CPC | Measurement of Nuclear or X-radiation G01T 1/22 (20130101) Original (OR) Class G01T 1/2006 (20130101) G01T 3/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220208204 | Sivaraman Narayanaswamy et al. |
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| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of Arizona State University (Tempe, Florida) |
| ASSIGNEE(S) | Lawrence Livermore National Security, LLC (Livermore, California); Arizona Board of Regents on Behalf of Arizona State University (Tempe, Arizona) |
| INVENTOR(S) | Vivek Sivaraman Narayanaswamy (Tempe, Arizona); Jayaraman Thiagarajan (Dublin, California); Rushil Anirudh (San Francisco, California); Andreas Spanias (Tempe, Arizona) |
| ABSTRACT | Various embodiments of a system and associated method for audio source separation based on generative priors trained on individual sources. Through the use of projected gradient descent optimization, the present approach simultaneously searches in the source-specific latent spaces to effectively recover the constituent sources. Though the generative priors can be defined in the time domain directly, it was found that using spectral domain loss functions leads to good-quality source estimates. |
| FILED | Wednesday, December 29, 2021 |
| APPL NO | 17/564502 |
| CURRENT CPC | Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 21/028 (20130101) Original (OR) Class G10L 25/18 (20130101) G10L 25/30 (20130101) Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 29/008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220208410 | Li et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); Samsung Electronics Co., Ltd. (Suwon-si, South Korea) |
| INVENTOR(S) | Ju Li (Weston, Massachusetts); Andrea Maurano (Somerville, Massachusetts); Yuming Chen (Cambridge, Massachusetts); Ziqiang WANG (Cambridge, Massachusetts); So Yeon Kim (Cambridge, Massachusetts) |
| ABSTRACT | A mixed ionic-electronic conductor (MIEC) in contact with a solid electrolyte includes a material having a bandgap less than 3 eV. The material includes an end-member phase directly connected to an alkali metal by a tie-line in an equilibrium phase diagram. The material is thermodynamically stable with a solid electrolyte. The MIEC includes plurality of open pores, formed within the MIEC, to facilitate motion of the alkali metal to at least one of store the alkali metal in the plurality of open pores or release the alkali metal from the plurality of open pores. The solid electrolyte has an ionic conductivity to ions of the alkali metal greater than 1 mS cm−1, a thickness less than 100 μm, and comprises at least one of a ceramic or a polymer. |
| FILED | Monday, March 14, 2022 |
| APPL NO | 17/694174 |
| CURRENT CPC | Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/02 (20130101) Original (OR) Class H01B 1/06 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/485 (20130101) H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 10/0565 (20130101) H01M 2300/0082 (20130101) H01M 2300/0085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220208539 | BADU-TAWIAH et al. |
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| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Abraham BADU-TAWIAH (Columbus, Ohio); Dmytro KULYK (Columbus, Ohio) |
| ABSTRACT | Disclosed herein are methods and systems for ionizing organic compounds by exposing head space vapors to corona discharge. The methods and systems are suitable for high throughput screening of samples, including biofluids. The methods and systems are suitable for rapid evaluation of chemical reactions, permitting discovery of novel organic reaction pathways. |
| FILED | Wednesday, April 29, 2020 |
| APPL NO | 17/607521 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 49/0031 (20130101) H01J 49/167 (20130101) Original (OR) Class H01J 49/168 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220208540 | Behsaz et al. |
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| FUNDED BY |
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| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bahar Behsaz (Pasadena, California); Liu Cao (Pittsburgh, Pennsylvania); Mustafa Guler (Pittsburgh, Pennsylvania); Yi-Yuan Lee (Ithaca, New York); Hosein Mohimani (Pittsburgh, Pennsylvania) |
| ABSTRACT | A method and system is for searching a database to identify structures of molecular compounds from mass spectrometry data. Operations of the method and system include receiving a query for a target molecular structure in the database, the query representing a query spectrum; accessing a machine learning model trained with molecule-spectrum pairs; inputting the query spectrum into the machine learning model; generating, from the machine learning model, a score for each of one or more molecular structures, each score representing a probability that a molecular structure corresponds to the query spectrum; selecting, based on each of the scores, a small molecule; and outputting, on a user interface, a representation of the small molecule. |
| FILED | Friday, December 17, 2021 |
| APPL NO | 17/554690 |
| CURRENT CPC | Peptides C07K 1/047 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6818 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 40/10 (20190201) Electric Discharge Tubes or Discharge Lamps H01J 49/26 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220209091 | ZHANG et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF NOTRE DAME DU LAC (South Bend, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yanliang ZHANG (South Bend, Indiana); Mortaza Saeidi-Javash (South Bend, Indiana) |
| ABSTRACT | Methods, ink compositions, and 3D conformal printed flexible films. The method may include aerosol jet printing a thermoelectric ink composition, followed by photonic or other sintering of the ink to remove surfactant included therein, and to convert the thermoelectric nanoparticles of the ink composition into a dense structure capable of charge carrier transport. The ink compositions may be solution-processed semimetal-chalcogenides (e.g., Te containing materials) in a suitable carrier (e.g., polyol(s), alcohol(s), etc.). A surfactant (e.g., PVP) may be present in the ink. Within seconds of photonic sintering, the electrical conductivity of the printed film is dramatically increased from non-conductive to a value on the order of at least 1×104 S/m. The films may demonstrate a room-temperature power factor of at least 500 μWm−1K−2. The realized values of 730-2200 μWm−1K−2 achieved are among the highest values reported for flexible thermoelectric films. The film is durable (e.g., 500 bending cycles with no significant performance drop). |
| FILED | Monday, June 08, 2020 |
| APPL NO | 17/609159 |
| CURRENT CPC | Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 7/61 (20180101) C09D 7/66 (20180101) C09D 11/36 (20130101) C09D 11/38 (20130101) C09D 11/52 (20130101) C09D 11/322 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 35/16 (20130101) Original (OR) Class H01L 35/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220209219 | Lopez et al. |
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| FUNDED BY |
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| APPLICANT(S) | Zenlabs Energy, Inc. (Fremont, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Herman A. Lopez (Sunnyvale, California); Yogesh Kumar Anguchamy (Newark, California); Haixia Deng (Fremont, California); Yongbong Han (San Francisco, California); Charan Masarapu (Fremont, California); Subramanian Venkatachalam (Pleasanton, California); Sujeet Kumar (Newark, California) |
| ABSTRACT | High capacity silicon based anode active materials are described for lithium ion batteries. These materials are shown to be effective in combination with high capacity lithium rich cathode active materials. Supplemental lithium is shown to improve the cycling performance and reduce irreversible capacity loss for at least certain silicon based active materials. In particular silicon based active materials can be formed in composites with electrically conductive coatings, such as pyrolytic carbon coatings or metal coatings, and composites can also be formed with other electrically conductive carbon components, such as carbon nanofibers and carbon nanoparticles. Additional alloys with silicon are explored. |
| FILED | Thursday, March 17, 2022 |
| APPL NO | 17/697031 |
| CURRENT CPC | Processes for the Electrolytic Removal of Materials From Objects; Apparatus Therefor C25F 3/12 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/38 (20130101) H01M 4/131 (20130101) H01M 4/133 (20130101) H01M 4/134 (20130101) Original (OR) Class H01M 4/364 (20130101) H01M 4/386 (20130101) H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 4/587 (20130101) H01M 4/621 (20130101) H01M 4/622 (20130101) H01M 10/0525 (20130101) H01M 2004/027 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220209224 | Tolbert et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Sarah H. Tolbert (Encino, California); Terri C. Lin (Fremont, California) |
| ABSTRACT | Nanoporous carbon coated lithium vanadium fluorophosphate materials and cathodes for fast charging li-ion batteries are described. Formation of the materials using polymer-templating is also described. |
| FILED | Wednesday, January 05, 2022 |
| APPL NO | 17/568898 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/366 (20130101) Original (OR) Class H01M 4/625 (20130101) H01M 4/5825 (20130101) H01M 10/0525 (20130101) H01M 2004/021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220209245 | Jones et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PPG Industries Ohio, Inc. (Cleveland, Ohio) |
| ASSIGNEE(S) | PPG Industries Ohio, Inc. (Cleveland, Ohio) |
| INVENTOR(S) | Olivia L. Jones (Cranberry Township, Pennsylvania); Stuart D. Hellring (Pittsburgh, Pennsylvania); Jacob W. Mohin (Pittsburgh, Pennsylvania); Haley L. Orler (Bridgeville, Pennsylvania); Samuel L. Esarey (Allison Park, Pennsylvania) |
| ABSTRACT | The present invention is directed towards an electrode comprising a porous electrical current collector comprising a surface comprising a plurality of apertures; a conformal coating present on at least a portion of the surface of the porous electrical current collector, the conformal coating comprising an electrochemically active material and an electrodepositable binder. Also disclosed herein are electrical storage devices comprising the electrode, and methods of preparing electrodes. |
| FILED | Tuesday, February 25, 2020 |
| APPL NO | 17/605299 |
| CURRENT CPC | Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/24 (20130101) H01G 11/28 (20130101) H01G 11/86 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/80 (20130101) Original (OR) Class H01M 4/0457 (20130101) H01M 4/623 (20130101) H01M 2004/021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220209247 | Xue et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of South Carolina (Columbia, South Carolina) |
| ASSIGNEE(S) | University of South Carolina (Columbia, South Carolina) |
| INVENTOR(S) | Xingjian Xue (Chapin, South Carolina); Chunlei Ren (West Columbia, South Carolina) |
| ABSTRACT | Described herein are novel alumina substrate-supported thin film SOFCs that may be produced at significantly reduced cost while providing improved robustness, high electrochemical performance, and the capability of effective carbon deposition resistance while still using Ni-cermet as an anode functional layer. |
| FILED | Thursday, October 28, 2021 |
| APPL NO | 17/512918 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/8626 (20130101) Original (OR) Class H01M 4/8807 (20130101) H01M 8/12 (20130101) H01M 2004/8684 (20130101) H01M 2008/1293 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220209277 | DUOSS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California); Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric DUOSS (Danville, California); Juergen BIENER (San Leandro, California); Patrick CAMPBELL (Oakland, California); Julie A. JACKSON (Livermore, California); Geoffrey M. OXBERRY (Pleasanton, California); Christopher SPADACCINI (Oakland, California); Michael STADERMANN (Pleasanton, California); Cheng ZHU (Livermore, California); Bradley TREMBACKI (Austin, Texas); Jayathi MURTHY (Austin, Texas); Matthew MERRILL (Charlottesville, Virginia) |
| ABSTRACT | The present disclosure relates to an electrical energy storage apparatus. The apparatus has an interpenetrating, three dimensional periodic structure formed from an ionically conductive solid electrolyte material having a plurality of interpenetrating, non-planar channels. The interpenetrating, non-planar channels are made up of a first plurality of channels filled with an anode material, a second plurality of channels adjacent the first plurality of channels and interpenetrating with the first plurality of channels, and filled with a cathode material, and a third plurality of channels adjacent to, and interpenetrating with, one of the first and second pluralities of channels, and filled with a material to form a separator. The first, second and third channels form a spatially dense, three dimensional structure. A first non-flat current collector layer is incorporated which is in communication with the first plurality of channels, and which forms a first electrode. A second non-flat current collector layer is incorporated which is in communication with the second non-planar channel, and which forms a second electrode. |
| FILED | Thursday, March 17, 2022 |
| APPL NO | 17/697375 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/26 (20130101) H01G 11/28 (20130101) H01G 11/52 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/02 (20130101) H01M 10/02 (20130101) Original (OR) Class H01M 10/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220209293 | Hersam et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark C. Hersam (Wilmette, Illinois); Woo Jin Hyun (Evanston, Illinois) |
| ABSTRACT | This invention discloses high-modulus, ion-conductive gel electrolytes and methods of making the gel electrolytes and electrochemical devices. The gel electrolytes include an ionic liquid and nanosheets mixed in the ionic liquid. The nanosheets in one example include exfoliated hexagonal boron nitride (hBN) nanosheets. Compared to conventional bulk hBN microparticles, exfoliated hBN nanosheets improve the mechanical properties of the gel electrolytes by about 2 orders of magnitude, while retaining high ionic conductivity at room temperature. Moreover, exfoliated hBN nanosheets are compatible with high-voltage cathodes, and impart exceptional thermal stability that allows high-rate operation of solid-state rechargeable lithium-ion batteries at high temperatures. |
| FILED | Monday, May 18, 2020 |
| APPL NO | 17/613166 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/382 (20130101) H01M 4/485 (20130101) H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 4/583 (20130101) H01M 10/0525 (20130101) H01M 10/0565 (20130101) Original (OR) Class H01M 2300/0082 (20130101) H01M 2300/0085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220209297 | Xiao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Jie Xiao (Richland, Washington); Bingbin Wu (Richland, Washington); Dianying Liu (Richland, Washington) |
| ABSTRACT | A nonflammable electrolyte comprises (a) at least four different salts; and a solvent comprising >50 vol % to 100 vol % of a flame retardant compound and optionally a cosolvent, wherein ((i) each salt comprises an anion with a different chemical composition than an anion of each of the other salts, (ii) cations of each of the salts are the same, the cations comprising lithium cations, sodium cations, or potassium cations, and (iii) a concentration of each of the salts is 5 mol % of a total molar concentration of the salts in the electrolyte; or (b) a difluoro(oxalato)borate or bis(oxalato)borate salt wherein a concentration of the salt is 40 mol % to 100 mol % of a total molar concentration of salts in the electrolyte, and a solvent comprising a flame retardant compound comprising an organic phosphate and a cosolvent comprising an organic carbonate solvent. |
| FILED | Wednesday, December 15, 2021 |
| APPL NO | 17/552340 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/662 (20130101) H01M 10/052 (20130101) H01M 10/0568 (20130101) Original (OR) Class H01M 10/0569 (20130101) H01M 2300/0028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220209310 | Ergen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Onur Ergen (Berkeley, California); Alexander K. Zettl (Kensington, California) |
| ABSTRACT | This disclosure provides systems, methods, and apparatus related to Li-ion batteries. In one aspect an electrolyte structure for use in a battery comprises an electrolyte and an interconnected boron nitride structure disposed in the electrolyte. |
| FILED | Tuesday, January 11, 2022 |
| APPL NO | 17/573488 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/056 (20130101) H01M 10/0525 (20130101) H01M 10/4235 (20130101) Original (OR) Class H01M 2300/0025 (20130101) H01M 2300/0045 (20130101) H01M 2300/0071 (20130101) H01M 2300/0085 (20130101) H01M 2300/0091 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220209587 | Kavimandan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Utkarsh D. Kavimandan (Oak Ridge, Tennessee); Veda P. Galigekere (Oak Ridge, Tennessee); Burak Ozpineci (Oak Ridge, Tennessee) |
| ABSTRACT | A system and method for sensorless coil detection that exploits a dead-time effect in a WPT inverter as an indicator of presence of a receiver. In one embodiment, a system described herein may be configured to detect arrival of a moving receiver prior to alignment of the moving receiver with the transmitter for power transmission. |
| FILED | Tuesday, December 28, 2021 |
| APPL NO | 17/563784 |
| CURRENT CPC | Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 7/0047 (20130101) H02J 7/007188 (20200101) H02J 50/10 (20160201) H02J 50/90 (20160201) Original (OR) Class H02J 2207/20 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220210054 | Beecroft et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hewlett Packard Enterprise Development LP (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan P. Beecroft (Bristol Somerset, United Kingdom); Edwin L. Froese (Burnaby Bristish Columbia, Canada) |
| ABSTRACT | Systems and methods are provided for “on the fly” routing of data transmissions in the presence of errors. Switches can establish flow channels corresponding to flows in the network. In response to encountering a critical error on a network link along a transmission path, a switch can generate an error acknowledgement. The switch can transmit the error acknowledgements to ingress ports upstream from the network link via the plurality of flow channels. By transmitting the error acknowledgement, it indicates that the network link where the critical error was encountered is a failed link to ingress ports upstream from the failed link. Subsequently, each ingress port upstream from the failed link can dynamically update the path of the plurality of flows that are upstream from the failed link such that the plurality of flows that are upstream from the failed link are routed in a manner that avoids the failed link. |
| FILED | Monday, March 23, 2020 |
| APPL NO | 17/594712 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 45/22 (20130101) H04L 45/28 (20130101) Original (OR) Class H04L 45/123 (20130101) H04L 45/125 (20130101) H04L 47/122 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220210058 | Bataineh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hewlett Packard Enterprise Development LP (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Abdulla M. Bataineh (Vista, California); Thomas L. Court (Three Lakes, Wisconsin); Edwin L. Froese (Burnaby British Columbia, Canada) |
| ABSTRACT | Systems and methods are provided for efficiently routing data through a network having a plurality of switches configured in a fat-tree topology, including: receiving a data transmission comprising a plurality of packets at an edge port of the network, and routing the data transmission through the network with routing decisions based upon a routing table, wherein the routing table includes entries to effect routing decisions based upon a destination based hash function. |
| FILED | Monday, March 23, 2020 |
| APPL NO | 17/594687 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 45/028 (20130101) H04L 45/28 (20130101) H04L 45/125 (20130101) H04L 45/566 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20220202289 | Samadani et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NEW YORK UNIVERSITY (New York, New York); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERAN AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Uzma Samadani (New York,, New York); Shani Offen (New York, New York); Marisa Carrasco-Queijeiro (New York,, New York); David Heeger (New York, New York) |
| ABSTRACT | A system includes an eye tracker having a camera, the eye tracker being configured and arranged to track an eye movement of a subject, and a processor in communication with the eye tracker, the processor being configured and arranged to create a dataset of the eye movement, generate a plot of the dataset, the plot reflecting a timecourse of eye position versus time, and identify one or more streaking vertical lines in the plot to indicate a deficit in cranial nerve II function. |
| FILED | Thursday, March 17, 2022 |
| APPL NO | 17/697860 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/024 (20130101) A61B 3/0025 (20130101) A61B 3/113 (20130101) Original (OR) Class A61B 5/031 (20130101) A61B 5/4064 (20130101) A61B 5/4076 (20130101) A61B 5/7246 (20130101) A61B 5/7264 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204484 | Mallampalli et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | Rama K. Mallampalli (Sewickley, Pennsylvania); Beibei Chen (Sewickley, Pennsylvania); Charleen T. Chu (Wexford, Pennsylvania); Yuan Liu (Sewickley, Pennsylvania) |
| ABSTRACT | A method for treating a neurodegenerative disease or an inflammatory disorder in a subject, comprising administering to the subject in need thereof, a compound, or a pharmaceutically acceptable salt thereof, of formula II: wherein each of R3-R7 is independently H, halogen, optionally-substituted alkyl, amino, alkoxy or hydroxy; R8 is an optionally-substituted heterocycloalkyl; and a is 0 to 3. |
| FILED | Monday, December 13, 2021 |
| APPL NO | 17/548914 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/517 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/16 (20180101) A61P 25/28 (20180101) Heterocyclic Compounds C07D 405/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220204564 | ZIMERING |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States Government As Represented By The Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | MARK B. ZIMERING (Lyons, New Jersey) |
| ABSTRACT | Disclosed herein, are decoy peptides or polypeptides capable of inhibiting binding of 5-HT2A autoantibodies to a second extracellular loop region of the 5-HT2A receptor, and a pharmaceutical composition containing the decoy peptides or polypeptides and methods of use. |
| FILED | Friday, March 04, 2022 |
| APPL NO | 17/687029 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/445 (20130101) A61K 31/517 (20130101) A61K 38/10 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) Peptides C07K 7/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Security Agency (NSA)
| US 20220206955 | Keppel |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Pardo Keppel (Mountain View, California) |
| ABSTRACT | A translation lookaside buffer (TLB) having a fixed sub-TLB and a configurable sub-TLB and methods of using the TLB are provided. The TLB includes a fixed sub-TLB and a configurable sub-TLB. The fixed sub-TLB, during runtime, may store a first plurality of TLB entries corresponding to a first page size set. The configurable sub-TLB, during runtime, is configurable to store a second plurality of TLB entries of a second page size set. The second page size set includes at least a first page size of the first page size set and includes at least a second page size not of the first page size set. |
| FILED | Saturday, December 26, 2020 |
| APPL NO | 17/134392 |
| CURRENT CPC | Electric Digital Data Processing G06F 12/1036 (20130101) Original (OR) Class G06F 12/1054 (20130101) G06F 12/1063 (20130101) G06F 2212/304 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220210054 | Beecroft et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hewlett Packard Enterprise Development LP (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan P. Beecroft (Bristol Somerset, United Kingdom); Edwin L. Froese (Burnaby Bristish Columbia, Canada) |
| ABSTRACT | Systems and methods are provided for “on the fly” routing of data transmissions in the presence of errors. Switches can establish flow channels corresponding to flows in the network. In response to encountering a critical error on a network link along a transmission path, a switch can generate an error acknowledgement. The switch can transmit the error acknowledgements to ingress ports upstream from the network link via the plurality of flow channels. By transmitting the error acknowledgement, it indicates that the network link where the critical error was encountered is a failed link to ingress ports upstream from the failed link. Subsequently, each ingress port upstream from the failed link can dynamically update the path of the plurality of flows that are upstream from the failed link such that the plurality of flows that are upstream from the failed link are routed in a manner that avoids the failed link. |
| FILED | Monday, March 23, 2020 |
| APPL NO | 17/594712 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 45/22 (20130101) H04L 45/28 (20130101) Original (OR) Class H04L 45/123 (20130101) H04L 45/125 (20130101) H04L 47/122 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220210058 | Bataineh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hewlett Packard Enterprise Development LP (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Abdulla M. Bataineh (Vista, California); Thomas L. Court (Three Lakes, Wisconsin); Edwin L. Froese (Burnaby British Columbia, Canada) |
| ABSTRACT | Systems and methods are provided for efficiently routing data through a network having a plurality of switches configured in a fat-tree topology, including: receiving a data transmission comprising a plurality of packets at an edge port of the network, and routing the data transmission through the network with routing decisions based upon a routing table, wherein the routing table includes entries to effect routing decisions based upon a destination based hash function. |
| FILED | Monday, March 23, 2020 |
| APPL NO | 17/594687 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 45/028 (20130101) H04L 45/28 (20130101) H04L 45/125 (20130101) H04L 45/566 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20220205930 | Klein |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Boulder Environmental Sciences and Technology (Boulder, Colorado) |
| ASSIGNEE(S) | Boulder Environmental Sciences and Technology (Boulder, Colorado) |
| INVENTOR(S) | Marian Klein (Boulder, Colorado) |
| ABSTRACT | A system for passive microwave remote sensing using at least one microwave radiometer includes a fixed body portion and a mobile body portion. The mobile body portion is configured for rotatably coupling with the fixed body portion for rotation about a rotation axis. The mobile body portion is configured for supporting the microwave radiometer therein such that the microwave radiometer rotates about the rotation axis when the mobile body portion is rotated about the rotation axis such that a polarization axis of the radiometer is aligned with an earth axis. The fixed body portion includes a motor mechanism for effecting rotation of the mobile body portion. In an embodiment, the mobile body portion includes a plurality of body section, each body section being configured for supporting a microwave radiometer therein. In another embodiment, each one of the plurality of body sections is configured to be interchangeably coupled with each other. |
| FILED | Wednesday, December 30, 2020 |
| APPL NO | 17/138268 |
| CURRENT CPC | Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 11/006 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 22/04 (20130101) Original (OR) Class Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags G01V 3/17 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220206866 | MAKSYMOV et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | IONQ, INC. (College Park, Maryland); University of Maryland (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrii MAKSYMOV (Hyattsville, Maryland); Pradeep NIROULA (College Park, Maryland); Yunseong NAM (North Bethesda, Maryland) |
| ABSTRACT | A method of performing a quantum computation process includes mapping, by a classical computer, logical qubits to physical qubits of a quantum processor so that quantum circuits are executable using the physical qubits of the quantum processor and a total infidelity of the plurality of quantum circuits is minimized, wherein each of the physical qubits comprise a trapped ion, and each of the plurality of quantum circuits comprises single-qubit gates and two-qubit gates within the plurality of the logical qubits, calibrating, by a system controller, two-qubit gates within a first plurality of pairs of physical qubits, such that infidelity of the two-qubit gates within the first plurality of pairs of physical qubit is lowered, executing the plurality of quantum circuits on the quantum processor, by applying laser pulses that each cause a single-qubit gate operation and a two-qubit gate operation in each of the plurality of quantum circuits on the plurality of physical qubits, measuring, by the system controller, population of qubit states of the physical qubits in the quantum processor after executing the plurality of quantum circuits on the quantum processor, and outputting, by the classical computer, the measured population of qubit states of the physical qubits as a result of the execution the plurality quantum circuits, wherein the result of the execution the plurality quantum circuits are configured to be displayed on a user interface, stored in a memory of the classical computer, or transferred to another computational device. |
| FILED | Friday, November 19, 2021 |
| APPL NO | 17/531520 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/5066 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 10/20 (20220101) G06N 10/40 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Environmental Protection Agency (EPA)
| US 20220204925 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Su-Chun Zhang (Waunakee, Wisconsin); Yunlong Tao (Madison, Wisconsin) |
| ABSTRACT | Methods for obtaining populations of norepinephrine (NE) neuronal progenitor cells and creating enriched populations of NE neurons are provided herein. Also provided herein are methods for obtaining genetically modified NE neurons expressing a NE sensor or a TH-reporter, and methods for using NE neurons obtained according to the methods of this disclosure. |
| FILED | Tuesday, December 28, 2021 |
| APPL NO | 17/563844 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0619 (20130101) Original (OR) Class C12N 2500/32 (20130101) C12N 2500/38 (20130101) C12N 2501/13 (20130101) C12N 2501/15 (20130101) C12N 2501/16 (20130101) C12N 2501/415 (20130101) C12N 2501/999 (20130101) C12N 2506/02 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5058 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220205967 | THOMA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MOLEX, LLC (Lisle, Illinois); UNITED STATES ENVIRONMENTAL PROTECTION AGENCY (Washington, District of Columbia) |
| ASSIGNEE(S) | MOLEX, LLC (Lisle, Illinois); UNITED STATES ENVIRONMENTAL PROTECTION AGENCY (Washington, District of Columbia) |
| INVENTOR(S) | Eben Daniel THOMA (Cary, North Carolina); Alexander S. CHERNYSHOV (Naperville, Illinois); Wenfeng PENG (North Aurora, Illinois); Ling-Yin LIN (Bloomingdale, Illinois); Jingxue XU (Chicago, Illinois) |
| ABSTRACT | A gas sensor network system provides near real-time monitoring of fugitive emissions of VOC compounds in chemical plants and facilities. The present disclosure provides a sensor placement method which determines where to place sensors within a facility. The sensor placement method includes obtaining plant layout, gas composition, meteorological conditions and/or other types of information regarding a facility, determining the types of gas and ancillary sensors needed, and generating the minimum detection distances required based on the sensitivities of the sensors to the gas compounds involved. And, then calculating the minimal number of sensors required for each sensor type with optimized sensor locations to ensure best coverage of potentially leaking components within the facility. |
| FILED | Friday, May 22, 2020 |
| APPL NO | 17/611916 |
| CURRENT CPC | Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 3/04 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/0006 (20130101) G01N 33/0075 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20220203442 | Firdosy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Samad A. Firdosy (Pasadena, California); Robert P. Dillon (Long Beach, California); Nicholas E. Ury (Pasadena, California); Katherine Dang (Pasadena, California); Joshua Berman (Pasadena, California); Pablo Narvaez (Pasadena, California); Vilupanur A. Ravi (Claremont, California); John Paul Castelo Borgonia (Monrovia, California); Joelle T. Cooperrider (Pasadena, California); Bryan W. McEnerney (Pasadena, California); Andrew A. Shapiro-Scharlotta (Glendale, California) |
| ABSTRACT | Systems and methods of additively manufacturing multi-material electromagnetic shields are described. Additive manufacturing processes use co-deposition to incorporate multiple materials and/or microstructures selected to achieve specified shield magnetic properties. Geometrically complex shields can be manufactured with alternating shielding materials optimized for the end use application. The microstructures of the printed shields can be tuned by optimizing the print parameters. |
| FILED | Thursday, August 05, 2021 |
| APPL NO | 17/394881 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 3/15 (20130101) B22F 7/02 (20130101) Original (OR) Class B22F 10/28 (20210101) B22F 10/64 (20210101) B22F 2301/35 (20130101) B22F 2304/10 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 40/20 (20200101) B33Y 80/00 (20141201) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 9/0081 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220209090 | Savoy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Nanohmics, Inc. (Austin, Texas) |
| ASSIGNEE(S) | Nanohmics, Inc. (Austin, Texas) |
| INVENTOR(S) | Steve M. Savoy (Austin, Texas); Giri Joshi (Austin, Texas); Michael McAleer (Austin, Texas); Rey Guzman (Austin, Texas); Scott Smith (Lago Vista, Texas); Robert Pearsall (Austin, Texas); Joshua C. Ruedin (Austin, Texas) |
| ABSTRACT | Thermoelectric devices have an electrically conductive connector for connecting thermoelectric modules. The electrically conductive connector is a compliant mechanism having a first connecting region and a second connecting region that are rigid bodies and an elastically deformable region that is a flexible member positioned between the first and second connecting regions. The electrically conductive compliant mechanism connector enables facile manufacture and assembly of thermoelectric devices of various sizes and shapes that are conformable to irregularly shaped objects and body parts. |
| FILED | Thursday, December 23, 2021 |
| APPL NO | 17/561002 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 25/04 (20130101) H01L 35/10 (20130101) Original (OR) Class H01L 35/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20220205879 | Fry |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Mark Fry (Marco Island, Florida) |
| ABSTRACT | In an example, a sample collection apparatus to collect sample from a detection subject disposed in a sample collection zone includes a circumferential ring tubing surrounding an interior and configured to be moved between first ring tubing position and second ring tubing position. The circumferential ring tubing includes air nozzles along a circumferential length of the ring tubing to direct targeted air flow within the sample collection zone as the ring tubing is moved between the first ring tubing position and the second ring tubing position, to blow air toward the detection subject in the sample collection zone in the interior and to push a sample of the detection subject via an air flow toward a receptacle. Adjustable actuators are affixed along a periphery of the circumferential ring tubing to adjust the circumferential length of the circumferential ring tubing between a first circumferential length and a second circumferential length. |
| FILED | Friday, March 18, 2022 |
| APPL NO | 17/698898 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/28 (20130101) G01N 1/2211 (20130101) Original (OR) Class G01N 1/2247 (20130101) G01N 2001/024 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Non-Profit Organization (NPO)
| US 20220207791 | Shi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Luyao Shi (New Haven, Connecticut); Chi Liu (Orange, Connecticut); John Onofrey (Woodbridge, Connecticut); Hui Liu (New Haven, Connecticut) |
| ABSTRACT | A system for estimating attenuation coefficients from only single photon emission computed tomography (SPECT) emission data using deep neural networks includes an artificial neural network based upon machine learning system estimating attenuation maps for SPECT emission data, and associated attenuation correction method. |
| FILED | Friday, April 17, 2020 |
| APPL NO | 17/594364 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Image Data Processing or Generation, in General G06T 11/003 (20130101) Original (OR) Class G06T 2207/10108 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Office of the Director of National Intelligence (ODNI)
| US 20220207909 | Raguin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ASSA ABLOY AB (Stockholm, Sweden) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Henri Raguin (North Palm Beach, Florida); George William McClurg (Jensen Beach, Florida); Aleksei Caesare Sebastiani (West Palm Beach, Florida); Markus Johannes Schiefele (Huntly, Virginia); Gregory Lewis Cannon (Lake Worth, Florida) |
| ABSTRACT | An apparatus for capturing an image of an object on a platen and including a platen having a surface for receiving the object, wherein the platen is transmissive to an optical wavelength of light, an illumination module configured to illuminate at least a portion of the object with light from an illumination source, and an optical sensing module configured to receive the light from the illumination source after the light interacts with the at least a portion of the object. The light from the illumination source is spatially patterned prior to reaching the object. The illumination module can be configured to create the spatially patterned illumination and/or the platen may include a patterned optical coating creating the spatially patterned illumination. The spatially patterned illumination can include a plurality of discrete areas (e.g., a stepped pattern) of different illumination intensity and/or a gradient of different illumination intensity. |
| FILED | Thursday, May 07, 2020 |
| APPL NO | 17/594931 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/0033 (20130101) Image or Video Recognition or Understanding G06V 10/143 (20220101) G06V 10/145 (20220101) G06V 10/774 (20220101) G06V 40/1318 (20220101) G06V 40/1394 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20220202325 | BASIRI |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Bioxytech Retina, Inc. (Richmond, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ali BASIRI (Pleasant Hill, California) |
| ABSTRACT | A method of determining a parameter related to a blood oxygenation of tissue may include projecting an optical pattern onto the issue, the optical pattern comprising a spatially varying component in at least one axis. A method of determining a parameter related to a blood oxygenation of tissue may include collecting a reflected optical signal from at least a first and a second wavelength range, wherein the first and the second wavelength ranges are distinct. A method of determining a parameter related to a blood oxygenation of tissue may include normalizing the reflected optical signal. A method of determining a parameter related to a blood oxygenation of tissue may include performing a transform of the reflected optical signal. A method of determining a parameter related to a blood oxygenation of tissue may include determining the parameter related to the blood oxygenation of the tissue based on the ratio and the transform. |
| FILED | Thursday, December 31, 2020 |
| APPL NO | 17/139898 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4088 (20130101) A61B 5/7257 (20130101) A61B 5/14555 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/4925 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) G16H 15/00 (20180101) G16H 50/20 (20180101) G16H 50/30 (20180101) G16H 50/50 (20180101) G16H 50/70 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20220202223 | Shenhar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joram Shenhar (Fairfax, Virginia); Joel Locknauth Dewnandan (Bladensburg, Maryland); William Albert Tartal (Baltimore, Maryland) |
| ABSTRACT | A retractable arm device, system, and method with a locking mechanism for preventing items placed in a device or receptacle from getting stuck, damaged, or torn. The retractable arm includes an inner tube, a pawl, and an outer tube surrounding the inner tube. The inner tube slides within the outer tube and the pawl preventing the retractable arm from moving into an extended position under particular conditions. The retractable arm may be placed in a receptacle for items to prevent the door from being reopened before the door is fully closed. |
| FILED | Friday, March 18, 2022 |
| APPL NO | 17/655513 |
| CURRENT CPC | Household or Table Equipment A47G 29/22 (20130101) A47G 29/122 (20130101) A47G 29/1207 (20130101) A47G 29/1251 (20170801) Original (OR) Class Devices for Moving Wings into Open or Closed Position; Checks for Wings; Wing Fittings Not Otherwise Provided For, Concerned With the Functioning of the Wing E05F 1/1008 (20130101) E05F 5/08 (20130101) Safes or Strong-rooms for Valuables; Bank Protection Devices; Safety Transaction Partitions E05G 7/001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20220204975 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); The Broad Institute, Inc. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); The Broad Institute, Inc. (Cambridge, Massachusetts) |
| INVENTOR(S) | David R. Liu (Cambridge, Massachusetts); James William Nelson (Cambridge, Massachusetts) |
| ABSTRACT | The present specification provides compositions and methods that are capable of directly installing an insertion or deletion of a given nucleotide at a specified genetic locus. The compositions and methods involve the novel combination of the use an engineered RNA enzyme (i.e., “ribozyme”) that is capable of site-specifically inserting or deleting a single nucleotide at a genetic locus and the use of a nucleic acid programmable DNA binding protein (napDNAbp) (e.g., Cas9) to target the engineered ribozyme to a specified genetic locus, thereby allowing for the direct installation of an insertion of deletion at the specified genetic locus by the engineered ribozyme. |
| FILED | Friday, April 10, 2020 |
| APPL NO | 17/602738 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/86 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 15/907 (20130101) C12N 2310/20 (20170501) C12N 2310/122 (20130101) C12N 2310/1241 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220205391 | Anderson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William C. Anderson (Evendale, Ohio); Thomas E . Agin (Evendale, Ohio); Michael William Murrish (Evendale, Ohio); Timothy McCann (Cincinnati, Ohio); Caitlin Ford (Cincinnati, Ohio) |
| ABSTRACT | In one aspect, the present disclosure is directed to a turbine rear frame link assembly for a turbofan engine. The turbofan engine includes an outer bypass duct and a gas turbine engine having an outer casing. The gas turbine engine is disposed in the outer bypass duct such that a bypass airflow passage is formed between the outer casing of the gas turbine engine and the outer bypass duct. The turbine rear frame link assembly includes a set of links coupled between the outer bypass duct and the outer casing to support the gas turbine engine relative to the outer bypass duct. The links are arranged around the gas turbine engine on a plane that is perpendicular to a centerline axis of the turbofan engine. None of the links extends through the bypass airflow passage at a position that intersects a radius extending in a vertically downward direction from the centerline axis. |
| FILED | Monday, December 28, 2020 |
| APPL NO | 17/135640 |
| CURRENT CPC | Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/20 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220206194 | Starkovich et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northrop Grumman Systems Corporation (Falls Church, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John A. Starkovich (Redondo Beach, California); Edward M. Silverman (Encino, California) |
| ABSTRACT | A high-performance optical absorber, having a texturized base layer, the base layer comprising one or more of a polymer film and a polymer coating; and a surface layer located above and immediately adjacent to the base layer. The surface layer is joined to the base layer and the surface layer has a plasma-functionalized, non-woven carbon nanotube (CNT) sheet, wherein the base layer texturization comprises one or more of substantially rectangular ridges, substantially triangular ridges, substantially pyramidal ridges, and truncated, substantially pyramidal ridges. |
| FILED | Tuesday, January 25, 2022 |
| APPL NO | 17/583446 |
| CURRENT CPC | Producing Particular Articles From Plastics or From Substances in a Plastic State B29D 11/0074 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Optical Elements, Systems, or Apparatus G02B 5/003 (20130101) Original (OR) Class G02B 2207/101 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220209831 | ROBINSON |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rampart Communications, Inc. (Annapolis, Maryland) |
| ASSIGNEE(S) | Rampart Communications, Inc. (Annapolis, Maryland) |
| INVENTOR(S) | Matthew Brandon ROBINSON (Crownsville, Maryland) |
| ABSTRACT | An apparatus includes a first communication device with multiple antennas, operably coupled to a processor and configured to access a codebook of transformation matrices. The processor generates a set of symbols based on an incoming data, and applies a permutation to each of the symbols to produce a set of permuted symbols. The processor transforms each of the permuted symbols based on at least one primitive transformation matrix, to produce a set of transformed symbols. The processor applies, to each of the transformed symbols, a precode matrix selected from the codebook of transformation matrices to produce a set of precoded symbols. The codebook of transformation matrices is accessible to a second communication device. The processor sends a signal to cause transmission, to the second communication device, of multiple signals, each representing a precoded symbol from the set of precoded symbols, each of the signals transmitted using a unique antenna from the plurality of antennas. |
| FILED | Tuesday, March 15, 2022 |
| APPL NO | 17/695703 |
| CURRENT CPC | Transmission H04B 7/0456 (20130101) Original (OR) Class H04B 7/0491 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, June 30, 2022.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20220630.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page