FedInvent™ Patent Applications
Application Details for Thursday, July 14, 2022
This page was updated on Monday, July 18, 2022 at 07:35 PM GMT
Department of Health and Human Services (HHS)
| US 20220217972 | Zhan et al. |
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| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Li Zhan (St. Paul, Minnesota); Mingang Li (Maple Grove, Minnesota); Thomas Hays (St. Paul, Minnesota); John Bischof (St. Paul, Minnesota) |
| ABSTRACT | Methods for cryopreservation of biological samples are provided. The biological samples are sub-millimeter or millimeter scale biological materials. The biological samples are embryos, such as Drosophila embryos. Methods for cryopreservation of Drosophila embryos using cryomesh are provided. The Drosophila embryos are collected, staged and treated to optimize the cryopreservation outcomes upon rewarming. Methods disclosed are efficient for maintaining stocks of Drosophila wild type and mutant strains. Methods are also disclosed for cryopreservation of other terrestrial organism embryos and/or aquatic organism embryos. |
| FILED | Monday, January 10, 2022 |
| APPL NO | 17/571802 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/033 (20130101) A01K 2227/706 (20130101) Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0284 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220218195 | BEGLEY et al. |
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| APPLICANT(S) | THE TRUSTEES OF INDIANA UNIVERSITY (Bloomingtion, Indiana) |
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| INVENTOR(S) | Carolyn G. BEGLEY (Bloomington, Indiana); Ping SITU (Bloomington, Indiana); Trefford L. SIMPSON (Waterloo, Canada) |
| ABSTRACT | Aspect of this invention include methods for measuring the connection between neurosensory abnormalities and dry eye and for testing the efficacy of new and existing therapies of the treatment of Dry Eye in patients with symptoms of this or related conditions. |
| FILED | Monday, June 01, 2020 |
| APPL NO | 17/609800 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/06 (20130101) Original (OR) Class A61B 3/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220218264 | Brunner et al. |
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| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri); Shanghai Jiao Tong University (Shanghai, China PRC); Fudan University (Shanghai, China PRC) |
| INVENTOR(S) | Peter Brunner (St. Louis, Missouri); Eric Leuthardt (St. Louis, Missouri); Tao Xie (Shanghai, China PRC); Zehan Wu (Shanghai, China PRC); Xinjun Sheng (Shanghai, China PRC); Liang Chen (Shanghai, China PRC); Xiangyang Zhu (Shanghai, China PRC) |
| ABSTRACT | Methods and systems are disclosed for analyzing interactions between low-frequency oscillations and high-frequency activity in electromagnetic brain signals such as EEG, MEG, SEEG, and ECoG signals in subjects in real-time that does not depend on the signals being contained within narrow frequency bands, sinusoidal, sustained and monolithic. The disclosed methods and systems can be applied to electromagnetic brain signals to detect brain activity alterations associated with neurological and psychiatric diseases. |
| FILED | Wednesday, January 12, 2022 |
| APPL NO | 17/574524 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/374 (20210101) A61B 5/725 (20130101) A61B 5/4064 (20130101) Original (OR) Class A61B 5/7246 (20130101) A61B 5/7257 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 23/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220218265 | SHEPARD et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenneth L. SHEPARD (Ossining, New York); Sajjad MOAZENI (New York, New York); Eric POLLMANN (New York, New York) |
| ABSTRACT | Exemplary embodiments of the present disclosure provide for an integrated, flexible, implantable, optical neural interrogation apparatus, computer-accessible medium, system, and method for use thereof An integrated, flexible, fully-implantable, all-optical neural interrogation apparatus can include, e.g., a 2-dimensional (2D) planar array of optical photodetectors on an integrated electronic chip, the integrated electronic chip including control logic and image-capturing electronic circuitry, an amplitude or phase optical imaging mask for imaging, and a biocompatible packaging. |
| FILED | Monday, January 24, 2022 |
| APPL NO | 17/582375 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0071 (20130101) A61B 5/0084 (20130101) A61B 5/4064 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/173 (20130101) H01L 31/03926 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220218513 | CARPICK et al. |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
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| INVENTOR(S) | Robert W. CARPICK (Philadelphia, Pennsylvania); Shu YANG (Blue Bell, Pennsylvania); José A. BAUERMEISTER (Philadelphia, Pennsylvania); Megan B. ELINSKI (Philadelphia, Pennsylvania); Alexander I. BENNETT (Philadelphia, Pennsylvania); Haihuan WANG (Philadelphia, Pennsylvania); Wei-Liang CHEN (Newtown, Pennsylvania); Christian POHLMANN (Fairfax Station, Virginia); Willey Y LIN (Philadelphia, Pennsylvania) |
| ABSTRACT | The invention concerns personal wellness products comprising: a self-lubricating, tough hydrogel material, the hydrogel material optionally comprising a double interpenetrating network (D-IPN) matrix. |
| FILED | Thursday, May 14, 2020 |
| APPL NO | 17/610334 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 6/04 (20130101) Original (OR) Class Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 31/10 (20130101) A61L 31/16 (20130101) A61L 31/145 (20130101) Compositions of Macromolecular Compounds C08L 33/26 (20130101) C08L 51/04 (20130101) C08L 51/085 (20130101) C08L 2203/02 (20130101) C08L 2205/03 (20130101) C08L 2312/00 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 133/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220218636 | JENNINGS et al. |
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| APPLICANT(S) | The University of Memphis Research Foundation (Memphis, Tennessee) |
| ASSIGNEE(S) | The University of Memphis Research Foundation (Memphis, Tennessee) |
| INVENTOR(S) | Jessica Amber JENNINGS (Memphis, Tennessee); Daniel Lee BAKER (Memphis, Tennessee); Rukhsana AWAIS (Memphis, Tennessee); Zoe HARRISON (Memphis, Tennessee); Babatunde RAJI (Memphis, Tennessee) |
| ABSTRACT | Compositions and methods for using cyclopropanated structural analogs of fatty acid biofilm dispersal agents are characterized by superior biofilm dispersion. When used in combination with antimicrobials, these analogs decrease the minimum inhibitory concentration of antimicrobial agents required for eradication of the biofilm and/or treatment of infection. Methods for using these analogs include direct application to a surface, blending with lipid based carriers, or covalent anchoring the molecule to a surface. Typically, the cyclopropanated structural analog has the structure according to formula (I): wherein R1 is a C1-C24 linear or branched alkyl group; or an acid halide or acid anhydride thereof. |
| FILED | Wednesday, March 23, 2022 |
| APPL NO | 17/702656 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 37/08 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/19 (20130101) Original (OR) Class A61K 47/36 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/02 (20180101) A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220218662 | Koliatsos et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
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| INVENTOR(S) | Vassilis E. Koliatsos (Baltimore, Maryland); Athanasios Alexandris (Baltimore, Maryland); Jiwon Ryu (Baltimore, Maryland) |
| ABSTRACT | Provided herein are methods for inhibiting or preventing neuron injury or death. The methods comprise contacting one or more neurons with small molecule modulators of one or more mitogen-activated kinase kinase kinases (MAP3Ks), a nicotinamide phosphoribosyltransferase (NAMPT), or a combination thereof. |
| FILED | Friday, January 07, 2022 |
| APPL NO | 17/570809 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/404 (20130101) Original (OR) Class A61K 31/506 (20130101) A61K 31/706 (20130101) A61K 31/4406 (20130101) A61K 31/4409 (20130101) A61K 31/4439 (20130101) A61K 31/4545 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/02 (20180101) A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220218668 | Bai et al. |
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| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Haiqing Bai (Cambridge, Massachusetts); Longlong Si (Cambridge, Massachusetts); Rachelle Prantil-Baun (Cambridge, Massachusetts); Donald E. Ingber (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure provides compositions and methods for inhibiting respiratory viral infections, inflammatory diseases, and/or respiratory inflammation. |
| FILED | Friday, February 11, 2022 |
| APPL NO | 17/669595 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/417 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/02 (20180101) A61P 31/12 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220218674 | Terzian et al. |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tamara Terzian (Aurora, Colorado); Neil Box (Aurora, Colorado) |
| ABSTRACT | Disclosed herein are compositions, methods, and systems useful in the prevention, management, or treatment of various conditions associated the lymphatic vasculature, including, but not limited to lymphedema. The disclosed methods and compositions are useful in reducing the activity of p53 in a subject at risk for or suffering from a disease or condition associated with lymphatic vasculature, including adults, children, infants, and embryos. Reduction in p53 activity may be achieve through reduction in one or more of p53 gene expression, p53 transcriptional activity, p53 DNA-binding affinity, etc. In many embodiments, the disease or condition is lymphedema, for example lymphedema associated with Milroy's disease, Klippel-Trenaunay and Cloves Syndromes. In many embodiments, treatment may involve administering a compound or pharmaceutically acceptable salt thereof to a subject in need thereof, exemplary compounds include, anti-p53 compounds, PFT, and PFT-β. |
| FILED | Monday, April 20, 2020 |
| APPL NO | 17/604858 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/428 (20130101) Original (OR) Class A61K 31/429 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220218710 | BARANZINI et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | SERGIO BARANZINI (San Francisco, California); ANNE-KATRIN PROEBSTEL (Basel, Switzerland); KICHEOL KIM (San Francisco, California) |
| ABSTRACT | The use of neddylation inhibitors to treat immune related conditions is described. Dysregulated immune and inflammatory responses underlie a number of conditions, including multiple sclerosis. Neddylation is involved in processes underlying the activation, activity, and proliferation of immune cells that drive these conditions, including CD4+ T cells. Inhibition of neddylation thus provides a target for intervention to prevent and treat such conditions. Inhibition of E1 NEDD8 activating enzymes, such as NAE may be utilized in treatment, for example by pevonedistat or other NAE inhibitors. |
| FILED | Thursday, April 30, 2020 |
| APPL NO | 17/608134 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220218722 | MOHLER et al. |
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| APPLICANT(S) | Health Research, Inc. (Buffalo, New York); University of Kentucky Research Foundation (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James L. MOHLER (Buffalo, New York); Michael V. FIANDALO (Buffalo, New York); David WATT (Lexington, Kentucky); Vitaliy SVIRIPA (Frederick, Maryland) |
| ABSTRACT | Provided are androstane and dihydrotestosterone compounds functionalized with carbocyclic groups or heterocyclic groups that may be saturated or unsaturated. The compounds may be used in methods of inhibiting cell growth of malignant cells and/or hyperplastic cells and/or treating individuals having diseases associated with malignant cell growth (e.g., cancer, such as, for example, prostate cancer) and/or hyperplastic cell growth and/or molecular imaging of malignant cells and/or hyperplastic cells and/or inducing degradation of a target protein. Also provided are compositions. |
| FILED | Monday, April 27, 2020 |
| APPL NO | 17/606998 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/58 (20130101) A61K 31/167 (20130101) A61K 31/277 (20130101) A61K 31/496 (20130101) A61K 31/585 (20130101) Original (OR) Class A61K 31/4155 (20130101) A61K 31/4166 (20130101) A61K 31/4439 (20130101) A61K 49/0002 (20130101) Steroids C07J 43/003 (20130101) C07J 43/006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220218748 | Scheinberg et al. |
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| FUNDED BY |
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| APPLICANT(S) | MEMORIAL SLOAN-KETTERING CANCER CENTER (New York, New York); SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (New York, New York); MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES (New York, New York) |
| ASSIGNEE(S) | MEMORIAL SLOAN-KETTERING CANCER CENTER (New York, New York); SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (New York, New York); MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES (New York, New York) |
| INVENTOR(S) | David A. Scheinberg (New York, New York); Leila Peraro (Cambridge, Massachusetts) |
| ABSTRACT | The presently disclosed subject matter provides cells and compositions for improved immunotherapy and methods of using such cells and compositions. It relates to cells comprising a ligand-recognizing receptor (e.g., an antigen-recognizing receptor, e.g., a chimeric antigen receptor (CAR) or a T-cell Receptor (TCR)) and an IgG-degrading enzyme or a fragment thereof. The IgG-degrading enzyme rapidly cleaves IgG. The IgG-degrading enzyme serves as a biomolecular shield against the host humoral response. The cells have increased resistance to host humoral response (e.g., an antibody-driven host humoral response), which allows for prolonged persistence of the cells, leading to enhanced activity of the cells. |
| FILED | Tuesday, February 01, 2022 |
| APPL NO | 17/590585 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class Peptides C07K 14/7051 (20130101) C07K 16/2833 (20130101) C07K 2317/24 (20130101) C07K 2317/622 (20130101) C07K 2317/734 (20130101) C07K 2319/03 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/6472 (20130101) Enzymes C12Y 304/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220218751 | Majzner et al. |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robbie G. Majzner (Palo Alto, California); Crystal L. Mackall (Stanford, California); Louai Labanieh (Palo Alto, California); Skyler P. Rietberg (San Francisco, California) |
| ABSTRACT | The present disclosure generally relates to, inter alia, novel chimeric polypeptides and chimeric antigen receptors (CARs) that include a hinge domain from CD28 and optionally a costimulatory domain not from CD28. The disclosure also provides compositions and methods useful for producing such molecules, as well as methods for the detection and treatment of diseases, such as cancer. |
| FILED | Wednesday, May 06, 2020 |
| APPL NO | 17/608709 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 35/76 (20130101) A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/7051 (20130101) C07K 14/7151 (20130101) C07K 14/70507 (20130101) C07K 14/70514 (20130101) C07K 14/70517 (20130101) C07K 14/70521 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220218752 | BAKER et al. |
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| APPLICANT(S) | University of Washington (Seattle, Washington); FRED HUTCHINSON CANCER RESEARCH CENTER (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David BAKER (Seattle, Washington); Scott BOYKEN (Seattle, Washington); Marc Joseph LAJOIE (Seattle, Washington); Robert A. LANGAN (Seattle, Washington); Stanley R. RIDDELL (Seattle, Washington); Alexander SALTER (Seattle, Washington) |
| ABSTRACT | Disclosed are protein switches that can sequester bioactive peptides and/or binding domains, holding them in an inactive (“off”) state, until combined with a second designed polypeptide called the key, which induces a conformational change that activates (“on”) the bioactive peptide or binding domain only when the protein switch components are co/localized when bound to their targets, components of such protein switches, and their use. |
| FILED | Monday, May 18, 2020 |
| APPL NO | 17/610083 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 38/1774 (20130101) Peptides C07K 14/005 (20130101) C07K 14/4747 (20130101) C07K 14/7051 (20130101) C07K 14/70596 (20130101) C07K 2319/30 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 15/86 (20130101) C12N 15/625 (20130101) C12N 2501/2302 (20130101) C12N 2510/00 (20130101) C12N 2740/15043 (20130101) C12N 2800/107 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220218757 | Marbán et al. |
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| APPLICANT(S) | Cedars-Sinai Medical Center (Los Angeles, California); Capricor, Inc. (Beverly Hills, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eduardo Marbán (Santa Monica, California); Ahmed Ibrahim (Los Angeles, California); Luis Rodriguez-Borlado (Manhattan Beach, California); Jennifer J. Moseley (Northborough, California); Chang Li (Harbor City, California) |
| ABSTRACT | Several embodiments relate to methods of generating cells with therapeutic potency. Several embodiments relate to generating cells as a source of exosomes with therapeutic potency. The cells and exosomes with therapeutic potency are useful for repairing and/or regenerating damaged or diseased tissue, for example. |
| FILED | Thursday, May 07, 2020 |
| APPL NO | 17/608636 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/33 (20130101) A61K 35/34 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0656 (20130101) C12N 5/0657 (20130101) C12N 2501/415 (20130101) C12N 2510/00 (20130101) C12N 2510/04 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5005 (20130101) G01N 2333/7055 (20130101) G01N 2333/70596 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220218761 | Leonard et al. |
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| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Maureen M. Leonard (Boston, Massachusetts); Alessio Fasano (Boston, Massachusetts); Victoria Kenyon (Cambridge, Massachusetts); Ali Zomorrodi (Auburndale, Massachusetts) |
| ABSTRACT | Methods for predicting whether a subject will develop a chronic inflammatory condition such as celiac disease, and methods and composition comprising anti-inflammatory microbes or metabolites that can be used to treat or reduce the risk of developing such conditions. |
| FILED | Wednesday, May 06, 2020 |
| APPL NO | 17/609137 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/19 (20130101) A61K 31/191 (20130101) A61K 31/7008 (20130101) A61K 35/74 (20130101) Original (OR) Class A61K 35/742 (20130101) A61K 35/745 (20130101) A61K 2035/115 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6812 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220218787 | Bucci et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vanni Bucci (Brookline, Massachusetts); Benedikt Mortzfeld (Cumberland, Rhode Island); Jacob Palmer (Oxford, United Kingdom) |
| ABSTRACT | This disclosure relates to genetically engineered microorganisms for treating or reducing the risk of bacterial infections or dysbiosis, and further discloses methods of making and using such microorganisms. |
| FILED | Friday, May 01, 2020 |
| APPL NO | 17/608053 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/741 (20130101) A61K 38/164 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 15/70 (20130101) C12N 15/635 (20130101) C12N 2510/00 (20130101) C12N 2800/101 (20130101) C12N 2830/002 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220218800 | KALEKO et al. |
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| FUNDED BY |
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| APPLICANT(S) | Synthetic Biologics, Inc. (Rockville, Maryland); Memorial Sloan Kettering Cancer Center (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael KALEKO (Rockville, Maryland); Sheila CONNELLY (Rockville, Maryland); Marcel R.M. VAN DEN BRINK (New York, New York); Jonathan PELED (New York, New York); Marina Burgos DA SILVA (New York, New York) |
| ABSTRACT | The present invention relates to, in part, methods and compositions for reducing the incidence and/or severity of complications associated with IV beta-lactam antibiotic use in allo-HCT recipients, such as aGVHD and VRE colonization and/or VRE bloodstream infection, using beta-lactamase agents. |
| FILED | Tuesday, May 05, 2020 |
| APPL NO | 17/608250 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/50 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/14 (20180101) A61P 37/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220218809 | McNeel et al. |
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| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Douglas G. McNeel (Madison, Wisconsin); Christopher D. Zahm (Madison, Wisconsin); Laura Johnson (Madison, Wisconsin) |
| ABSTRACT | The present invention provides compositions and methods of treating prostate cancer using a combination of a DNA vaccine, PD-1 inhibitor and an IDO inhibitor. Further, methods of measuring IDO activity as a way to identify a subpopulation of subjects with prostate cancer that may benefits from the treatment methods described herein are provided. |
| FILED | Wednesday, November 06, 2019 |
| APPL NO | 17/291159 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4245 (20130101) A61K 39/001193 (20180801) Original (OR) Class A61K 39/3955 (20130101) A61K 2039/53 (20130101) A61K 2039/545 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20220218824 — MULTI-SPECIFIC ANTIBODIES FOR CROSS-NEUTRALIZATION OF MULTIPLE FILOVIRUS GLYCOPROTEINS
| US 20220218824 | Lai et al. |
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| FUNDED BY |
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| APPLICANT(S) | Albert Einstein College of Medicine (Bronx, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan R. Lai (Dobbs Ferry, New York); Julia Frei (Bronx, New York); Elisabeth Nyakatura (New York, New York) |
| ABSTRACT | Methods for treating and for preventing filovirus infections are disclosed, as well as compositions therefor. |
| FILED | Tuesday, September 28, 2021 |
| APPL NO | 17/487690 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/42 (20130101) Original (OR) Class Peptides C07K 16/10 (20130101) C07K 2317/24 (20130101) C07K 2317/31 (20130101) C07K 2317/64 (20130101) C07K 2317/76 (20130101) C07K 2317/622 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220218834 | SUSIN PIRES et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ivan SUSIN PIRES (Cambridge, Massachusetts); Andre PALMER (Bexley, Ohio); Pedro J. CABRALES AREVALO (La Mesa, California) |
| ABSTRACT | Provided herein are apohemoglobin-haptoglobin complexes as well as apohemoglobin-haptoglobin complexes comprising an active agent coordinated thereto. Methods of using these compositions are also described. |
| FILED | Wednesday, May 20, 2020 |
| APPL NO | 17/613351 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 41/0071 (20130101) A61K 47/52 (20170801) A61K 47/64 (20170801) A61K 47/552 (20170801) A61K 47/6445 (20170801) Original (OR) Class A61K 49/14 (20130101) A61K 49/0032 (20130101) A61K 49/0036 (20130101) A61K 49/0056 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220218843 | Venditti et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | LogicBio Therapeutics, Inc. (Lexington, Massachusetts); The United States of America, as Represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| ASSIGNEE(S) | LogicBio Therapeutics, Inc. (Lexington, Massachusetts) |
| INVENTOR(S) | Charles P. Venditti (Bethesda, Maryland); Randy J. Chandler (Bethesda, Maryland); B. Nelson Chau (Needham, Massachusetts); Kyle P. Chiang (Arlington, Massachusetts); Jing Liao (Lexington, Massachusetts) |
| ABSTRACT | Methods and technologies for the treatment of methylmalonic acidemia. |
| FILED | Tuesday, October 30, 2018 |
| APPL NO | 17/267482 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 2217/075 (20130101) A01K 2227/105 (20130101) A01K 2267/035 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 48/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/90 (20130101) C12N 15/86 (20130101) C12N 15/907 (20130101) C12N 2750/14122 (20130101) C12N 2750/14143 (20130101) C12N 2750/14145 (20130101) Enzymes C12Y 504/99002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220218867 | Sheikhi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Amir Sheikhi (State College, Pennsylvania); Nasim Annabi (Los Angeles, California); Alireza Khademhosseini (Los Angeles, California) |
| ABSTRACT | Naturally-derived biopolymers, such as proteins and polysaccharides are a promising platform for developing materials that readily adhere to tissues upon chemical crosslinking and provide a regenerative microenvironment. Here, we show that the sealing properties of a model biopolymer sealant, gelatin methacryloyl (GelMA), can be precisely controlled by adding a small amount of a synthetic polymer with identically reactive moieties, i.e., poly (ethylene glycol) diacrylate (PEG DA). For example, we have discovered a more than 300% improvement in tissue sealing capability of 20% (w/v) GelMA adhesive can be obtained by adding only 2-3% (v/v) PEGDA, without any significant effect on the sealant degradation time scale. These hybrid hydrogels with improved sealing properties are suitable for sealing stretchable organs, such as bladder, as well as for the anastomosis of tubular tissues/organs. |
| FILED | Wednesday, May 20, 2020 |
| APPL NO | 17/608706 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 24/0015 (20130101) A61L 24/0031 (20130101) A61L 24/0042 (20130101) A61L 24/043 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220218880 | Kim et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Maria Kim (Ann Arbor, Michigan); Elizabeth J. Brisbois (Athens, Georgia); Joshua C. Doverspike (Ann Arbor, Michigan); Shale J. Mack (Ann Arbor, Michigan); Orsolya I. Lautner-Csorba (Ann Arbor, Michigan); Kamila Katarzyna Konopinska (Vista, California); Mark E. Meyerhoff (Ann Arbor, Michigan) |
| ABSTRACT | A catheter insert device includes a powder composition, and a housing. The powder composition includes a solid phase S-nitrosothiol (RSNO). The housing includes a polymeric wall that is i) permeable to nitric oxide, ii) non-porous, and iii) permeable to water vapor, and an inner lumen defined at least in part by the polymeric wall. The powder composition is completely sealed within the inner lumen of the housing. |
| FILED | Tuesday, June 09, 2020 |
| APPL NO | 17/617507 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 29/02 (20130101) A61L 29/06 (20130101) A61L 29/16 (20130101) Original (OR) Class A61L 2300/60 (20130101) A61L 2300/114 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 25/0043 (20130101) A61M 2025/0056 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220218907 | Frizzell et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Deborah Lynn Fuller (Seattle, Washington); James Thomas Fuller (Seattle, Washington); Orlance, Inc. (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hannah Elise Frizzell (Seattle, Washington); Kristyn Rene Aalto (Kingston, Washington); Amanda Kay Woodcock (Seattle, Washington); Dennis Earl McCabe (Seattle, Washington); Deborah Lynn Fuller (Bainbridge Island, Washington); James Thomas Fuller (Bainbridge Island, Washington) |
| ABSTRACT | Disclosed and claimed is a medical delivery device with a separable housing comprising a durable component and a disposable component. The durable component comprises a handle portion of the device that may be connected to a compressed gas source to allow for the input of pressurized gas into the device. The disposable component comprises a cartridge containing a plurality of doses of biological or non-biological material and a supersonic barrel through which the dose is propelled out of the device and into the subject. When all of the doses in the cartridge have been administered, or when the device is to be used with a different subject, the cartridge is removed, and a new cartridge attached to the durable component. |
| FILED | Friday, January 07, 2022 |
| APPL NO | 17/571047 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/30 (20130101) Original (OR) Class A61M 5/2053 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220219019 | XU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhen XU (Ann Arbor, Michigan); Jonathan SUKOVICH (Ann Arbor, Michigan); Aditya S. PANDEY (Ann Arbor, Michigan); Charles A. CAIN (Ann Arbor, Michigan); Hitinder S. GURM (Ann Arbor, Michigan) |
| ABSTRACT | A histotripsy therapy system configured for the treatment of brain tissue is provided, which may include any number of features. In one embodiment, the system includes an ultrasound therapy transducer, a drainage catheter, and a plurality of piezoelectric sensors disposed in the drainage catheter. The ultrasound therapy is configured to transmit ultrasound pulses into the brain to generate cavitation that liquefies a target tissue in the brain. The drainage catheter is configured to detect the ultrasound pulses. An aberration correction algorithm can be executed by the system based on the ultrasound pulses measured by the drainage catheter to automatically correct for an aberration effect caused by the ultrasound pulses passing through a skullcap of the patient. |
| FILED | Friday, August 20, 2021 |
| APPL NO | 17/407780 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 7/00 (20130101) A61N 7/02 (20130101) Original (OR) Class A61N 2007/003 (20130101) A61N 2007/0039 (20130101) A61N 2007/0047 (20130101) A61N 2007/0065 (20130101) A61N 2007/0078 (20130101) A61N 2007/0086 (20130101) A61N 2007/0095 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220219155 | Rovis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tomislav Rovis (Scarsdale, New York); Cedric Theunissen (New York, New York) |
| ABSTRACT | The present disclosure provides compositions and methods for metathesizing a first alkenyl or alkynyl group with a second alkenyl or alkynyl group, the composition comprising a ruthenium metathesis catalyst and a photoredox catalyst that is activated by visible light. |
| FILED | Thursday, March 10, 2022 |
| APPL NO | 17/691257 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/0275 (20130101) B01J 31/2273 (20130101) Original (OR) Class B01J 31/2291 (20130101) B01J 35/004 (20130101) B01J 2231/543 (20130101) B01J 2531/821 (20130101) Acyclic or Carbocyclic Compounds C07C 6/04 (20130101) C07C 6/06 (20130101) C07C 2531/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220219166 | Furtaw et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | LI-COR, Inc. (Lincoln, Nebraska) |
| ASSIGNEE(S) | LI-COR, Inc. (Lincoln, Nebraska) |
| INVENTOR(S) | Michael D. Furtaw (Lincoln, Nebraska); Donald T. Lamb (Lincoln, Nebraska) |
| ABSTRACT | A multilayered microfluidic chip integrating separation channels and a common piezoelectric pump dispensing to a blotting membrane is described. A top layer with separation channels is connected with vias through a middle layer to a nozzle area in a bottom layer that has a piezoelectric pump. Because each via is very near a separate orifice in the bottom layer, the buffer fluid in the bottom layer will quickly dispense analyte emerging from the via. The analyte is pumped out of the orifice carried by the buffer fluid. A common reservoir of buffer fluid, connected with the pump membrane, is used. Electrodes may be placed near the entrance of each separation channel and share a terminating electrode in the common reservoir. |
| FILED | Thursday, January 13, 2022 |
| APPL NO | 17/575275 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/567 (20130101) B01L 3/502715 (20130101) Original (OR) Class B01L 2200/10 (20130101) B01L 2300/12 (20130101) B01L 2300/0645 (20130101) B01L 2400/0406 (20130101) B01L 2400/0439 (20130101) B01L 2400/0622 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/44739 (20130101) G01N 27/44791 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220219171 | Siltanen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); Scribe Biosciences Inc. (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christian Siltanen (San Francisco, California); Russell Cole (San Francisco, California); Adam R. Abate (Daly City, California); Justin Madrigal (San Francisco, California); Maithreyan Srinivasan (Palo Alto, California) |
| ABSTRACT | Methods for selectively combining discrete entities including, e.g. cells, reagents, drugs, hydrogels, extracellular matrices beads, particles, biological materials, media, or a combination thereof, are provided. In certain aspects, the methods include sorting a plurality of discrete entities and trapping two or more discrete entities for a time sufficient for the two or more discrete entities to combine to form a combined discrete entity. In certain aspects, the methods include making the plurality of discrete entities. In certain aspects, the methods include detecting or analyzing the discrete entities, e.g. via optical detection. In certain aspects, the methods include manipulating or analyzing the combined discrete entity or a component therein, e.g. imaging, sequencing, culturing, e.g., three-dimensional culturing, and measuring cell-cell interactions. Systems and devices for practicing the subject methods are also provided. |
| FILED | Wednesday, May 13, 2020 |
| APPL NO | 17/595054 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) Original (OR) Class B01L 2200/10 (20130101) B01L 2200/16 (20130101) B01L 2200/025 (20130101) B01L 2200/0636 (20130101) B01L 2200/0652 (20130101) B01L 2200/0673 (20130101) B01L 2300/0663 (20130101) B01L 2300/0864 (20130101) B01L 2400/086 (20130101) B01L 2400/0638 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220220014 | Ball |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | OXYTEC LLC (Newton, Massachusetts) |
| ASSIGNEE(S) | OXYTEC LLC (Newton, Massachusetts) |
| INVENTOR(S) | Raymond G. Ball (Newton, Massachusetts) |
| ABSTRACT | Disclosed are methods, apparatuses and systems for the remediation of contaminated soils, groundwater, water, and/or waste using a combination of reagents. The disclosed methods may be used to treat various recalcitrant halogenated substances, such as perfluoroalkyls and polyfluoroalkyls. Particular combinations of reagents that may be used in the disclosed methods include but are not limited to: (1) persulfate, oxygen and ozone; (2) persulfate, salt, oxygen and ozone; (3) persulfate, phosphate, and/or oxygen; (4) persulfate, phosphate, oxygen and ozone; (5) persulfate, phosphate, salt and oxygen (6) persulfate, phosphate, salt, oxygen and ozone; (7) oxygen and salt; and (8) air and salt. The disclosed methods may enhance destruction of organic contaminants in the liquid phase and may also control the rate of aerosol or foam formation relative to the rate of chemical oxidation and/or reduction/transfer. |
| FILED | Monday, March 28, 2022 |
| APPL NO | 17/706128 |
| CURRENT CPC | Reclamation of Contaminated Soil B09C 1/002 (20130101) B09C 1/06 (20130101) B09C 1/08 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/32 (20130101) C02F 1/70 (20130101) C02F 1/78 (20130101) C02F 1/722 (20130101) Original (OR) Class C02F 1/725 (20130101) C02F 1/727 (20130101) C02F 2101/36 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220220078 | MALONEY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC (Bethesda, Maryland); VANDERBILT UNIVERSITY (Nashville, Tennessee); The UAB Research Foundation (Birmingham, Alabama); The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David J. MALONEY (Point of Rocks, Maryland); Alex Gregory WATERSON (Nashville, Tennessee); Ganesh Rai BANTUKALLU (Arlington, Virginia); Kyle Ryan BRIMACOMBE (Bethesda, Maryland); Plamen CHRISTOV (Nashville, Tennessee); Chi V. DANG (Penn Valley, Pennsylvania); Victor DARLEY-USMAR (Birmingham, Alabama); Xin HU (Frederick, Maryland); Ajit JADHAV (Chantilly, Virginia); Somnath JANA (Nashville, Tennessee); Kwangho KIM (Nashville, Tennessee); Jennifer L. KOUZNETSOVA (Silver Spring, Maryland); William J. MOORE (Hagerstown, Maryland); Bryan T. MOTT (College Park, Maryland); Leonard M. NECKERS (Bethesda, Maryland); Anton SIMEONOV (Bethesda, Maryland); Gary Allen SULIKOWSKI (Nashville, Tennessee); Daniel Jason URBAN (Rockville, Maryland); Shyh Ming YANG (Doylestown, Pennsylvania) |
| ABSTRACT | Provided is a compound of formula (I) in which Ar1, R1, U, V, W, X, and p are as described herein. Also provided are methods of using a compound of formula (I), including a method of treating cancer, a method of treating a patient with cancer cells resistant to an anti-cancer agent, and a method of inhibiting lactate dehydrogenase A (LDHA) and/or lactate dehydrogenase B (LDHB) activity in a cell. |
| FILED | Monday, January 10, 2022 |
| APPL NO | 17/572359 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/415 (20130101) A61K 31/422 (20130101) A61K 31/427 (20130101) A61K 31/437 (20130101) A61K 31/454 (20130101) A61K 31/496 (20130101) A61K 31/501 (20130101) A61K 31/506 (20130101) A61K 31/519 (20130101) A61K 31/4155 (20130101) A61K 31/4178 (20130101) A61K 31/4439 (20130101) A61K 31/5355 (20130101) A61K 45/06 (20130101) Heterocyclic Compounds C07D 231/20 (20130101) Original (OR) Class C07D 231/38 (20130101) C07D 401/04 (20130101) C07D 403/04 (20130101) C07D 403/06 (20130101) C07D 409/04 (20130101) C07D 413/04 (20130101) C07D 417/04 (20130101) C07D 417/14 (20130101) C07D 471/04 (20130101) C07D 495/04 (20130101) C07D 495/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220220102 | NEWMAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amy Hauck NEWMAN (Bethesda, Maryland); Alessandro BONIFAZI (Bethesda, Maryland); Francisco Oscar BATTITI (Bethesda, Maryland); Sophie L. CEMAJ (Bethesda, Maryland) |
| ABSTRACT | Disclosed herein are novel compounds including dopamine D3 receptor agonists, compositions thereof, methods of use thereof, and processes of synthesizing the same. Further disclosed are D3R selective agonist compounds, specifically bitopic ligands comprising chirality. |
| FILED | Monday, April 13, 2020 |
| APPL NO | 17/602504 |
| CURRENT CPC | Heterocyclic Compounds C07D 413/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220220134 | Muir et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| INVENTOR(S) | Tom W. Muir (Princeton, New Jersey); Rob C. Oslund (Princeton, New Jersey); Jung-Min Kee (Ulsan, South Korea) |
| ABSTRACT | Provided are phosphonopyrazole-based phosphohistidine analogs that are useful as haptens for the preparation of immunogens, immunogens that include these haptens linked to carrier molecules, antibodies thereto and uses of these antibodies, haptens, immunogens and phosphohistidine analogs. |
| FILED | Tuesday, March 29, 2022 |
| APPL NO | 17/707330 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/65031 (20130101) Original (OR) Class Peptides C07K 16/44 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5308 (20130101) G01N 2800/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220220153 | CAI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of South Florida (Tampa, Florida); H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE INC. (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jianfeng CAI (Tampa, Florida); Peng SANG (Tampa, Florida); Yan SHI (Tampa, Florida); Haitao JI (Tampa, Florida); Min ZHANG (Tampa, Florida) |
| ABSTRACT | Disclosed herein is a series of helical sulfono-γ-AApeptides that mimic the binding mode of the α-helical HD2 domain of B-Cell Lymphoma 9 (BCL9). As disclosed herein, sulfono-γ-AApeptides can structurally and functionally mimic the α-helical domain of BCL9, and selectively disrupt β-catenin/BCL9 PPIs with even higher potency. More intriguingly, these sulfono-γ-AApeptides can enter cancer cells, bind with β-catenin and disrupt β-catenin/BCL PPI, and exhibit excellent cellular activity, which is much more potent than the BCL9 peptide. Furthermore, enzymatic stability studies demonstrated the remarkable stability of the helical sulfono-γ-AApeptides, with no degradation in the presence of pronase for 24 h, augmenting their biological potential. |
| FILED | Friday, April 24, 2020 |
| APPL NO | 17/605219 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/08 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 7/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220220168 | Barnes et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH (Manhasset, New York) |
| ASSIGNEE(S) | THE FEINSTEIN INSTITUES FOR MEDICAL RESEARCH (Manhasset, New York) |
| INVENTOR(S) | Betsy J. Barnes (Glenwood Landing, New York); Shan Sun (Wingdale, New York) |
| ABSTRACT | Polypeptides comprising a cell penetrating amino acid sequence and an interferon regulatory factor 5 (IRF5) targeting amino acid sequence are disclosed, where the IRF5 targeting amino acid sequence is one or more of RHATRHG (SEQ ID NO:1), KSRDFRL (SEQ ID NO:2) and GPRDMPP (SEQ ID NO:3), as well as methods of using these polypeptides to treat diseases, such as autoimmune and inflammatory diseases. |
| FILED | Monday, May 04, 2020 |
| APPL NO | 17/608487 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/00 (20180101) Peptides C07K 14/47 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220220173 | Wang |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (CLEVELAND, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xinglong Wang (Cleveland, Ohio) |
| ABSTRACT | A method of treating a neurodegenerative disease in a subject includes administering to the subject a therapeutically effective amount of a TDP-43 mitochondrial localization inhibitor. |
| FILED | Tuesday, September 21, 2021 |
| APPL NO | 17/480884 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Peptides C07K 7/06 (20130101) C07K 14/4713 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220220206 | Ibrahim |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Samar H. Ibrahim (Rochester, Minnesota) |
| ABSTRACT | This document provides methods and materials involved in treating chronic liver disease (e.g., non-alcoholic fatty liver disease such as nonalcoholic steatohepatitis (NASH)). For example, methods and materials for using one or more inhibitors of an integrin β1 (ITGβ1) polypeptide, one or more inhibitors of an integrin α9 polypeptide (ITGα9), and/or one or more inhibitors of a vascular cell adhesion molecule 1 (VCAM-1) polypeptide to treat a mammal having chronic liver disease are provided. |
| FILED | Wednesday, May 20, 2020 |
| APPL NO | 17/612286 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) Peptides C07K 16/2836 (20130101) C07K 16/2842 (20130101) Original (OR) Class C07K 2317/76 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220220212 | NGUYEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for The State University of New York (Amherst, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Juliane NGUYEN (Buffalo, New York); Michael DECI (Buffalo, New York) |
| ABSTRACT | Provided herein are single chain variable fragment antibodies that are directed against N-terminal or extracellular loop regions of CCR2. The scFvs can be used alone or in combination to modify macrophage number and migration and to reduce the growth of tumors. |
| FILED | Wednesday, May 13, 2020 |
| APPL NO | 17/611119 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2866 (20130101) Original (OR) Class C07K 2317/56 (20130101) C07K 2317/565 (20130101) C07K 2317/622 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220220438 | Visconti et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pablo E. Visconti (Amherst, Massachusetts); Felipe Navarrete (Boston, Massachusetts) |
| ABSTRACT | Methods for improving the functionality and/or fertility of sperm, for example, by enhancing motility and/or extending the lifespan of sperm by subjecting the isolated sperm to a starvation protocol and/or ionophore are provided. Such methods may be used in, for example, artificial insemination to reduce the number of sperm needed for insemination and to improve conception rates. |
| FILED | Thursday, February 17, 2022 |
| APPL NO | 17/651505 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0205 (20130101) Diagnosis; Surgery; Identification A61B 17/43 (20130101) A61B 17/435 (20130101) Veterinary Instruments, Implements, Tools, or Methods A61D 19/02 (20130101) A61D 19/04 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/061 (20130101) C12N 5/0604 (20130101) Original (OR) Class C12N 15/00 (20130101) C12N 2501/998 (20130101) C12N 2501/999 (20130101) C12N 2517/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220220446 | EVANS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Salk Institute for Biological Studies (La Jolla, California) |
| ASSIGNEE(S) | Salk Institute for Biological Studies (La Jolla, California) |
| INVENTOR(S) | Ronald EVANS (La Jolla, California); Michael DOWNES (La Jolla, California); Annette ATKINS (La Jolla, California); Eiji YOSHIHARA (La Jolla, California); Ruth YU (La Jolla, California) |
| ABSTRACT | The invention features pancreatic islet and pancreatic organoids, and cell cultures and methods that are useful for the rapid and reliable generation of pancreatic islet and pancreatic islet organoids. The invention also features methods of treating pancreatic diseases and methods of identifying agents that are useful for treatment of pancreatic diseases, such as type 2 diabetes and pancreatic cancer, using the pancreatic islet and pancreatic organoids of the invention. |
| FILED | Monday, March 28, 2022 |
| APPL NO | 17/706272 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/39 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0677 (20130101) Original (OR) Class C12N 2501/16 (20130101) C12N 2501/117 (20130101) C12N 2501/385 (20130101) C12N 2501/395 (20130101) C12N 2501/415 (20130101) C12N 2501/727 (20130101) C12N 2501/999 (20130101) C12N 2502/28 (20130101) C12N 2502/1382 (20130101) C12N 2503/02 (20130101) C12N 2506/02 (20130101) C12N 2506/45 (20130101) C12N 2513/00 (20130101) C12N 2533/52 (20130101) C12N 2533/54 (20130101) C12N 2533/90 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5088 (20130101) G01N 2800/04 (20130101) G01N 2800/7028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220220448 | Huang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Cleveland Clinic Foundation (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Emina Huang (Cleveland, Ohio); Samaneh Kamali (Lakewood, Ohio) |
| ABSTRACT | Provided herein are compositions, systems, kits, and methods that employ a colitic induced human colitic organoid (iHCO) that has both an epithelial compartment and mesenchymal compartment, and provides at least one feature (e.g., leaky epithelial barrier) of IBD patient tissue (e.g., ulcerative colitis or Crohn's disease tissue). In certain embodiments, such iHCO's are employed in vitro or in vivo to screen candidate IBD treating compounds (e.g., to determine effectiveness for a particular patient who was the source of the original colonic fibroblasts used to generate the iHCO). |
| FILED | Wednesday, May 13, 2020 |
| APPL NO | 17/609957 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/0008 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0679 (20130101) Original (OR) Class C12N 2500/38 (20130101) C12N 2501/11 (20130101) C12N 2501/15 (20130101) C12N 2501/16 (20130101) C12N 2501/119 (20130101) C12N 2501/415 (20130101) C12N 2506/23 (20130101) C12N 2506/45 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5044 (20130101) G01N 33/5088 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220220449 | Eguchi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Asuka Eguchi (Menlo Park, California); Aseem Z. Ansari (Germantown, Tennessee) |
| ABSTRACT | The present invention relates to artificial transcription factors (ATFs) that alter gene expression, including inducing pluripotency in cells or promoting the conversion of cells to specific cell fates. In particular, provided herein is a zinc-finger based ATF library that can be screened in cells by looking for expression of a specific gene (e.g., reporter expression), monitoring for cell surface markers or morphology, or via functional assays. |
| FILED | Wednesday, June 16, 2021 |
| APPL NO | 17/349243 |
| CURRENT CPC | Peptides C07K 1/047 (20130101) C07K 14/4702 (20130101) C07K 2319/09 (20130101) C07K 2319/81 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0647 (20130101) C12N 5/0657 (20130101) C12N 5/0696 (20130101) Original (OR) Class C12N 2500/25 (20130101) C12N 2501/40 (20130101) C12N 2501/60 (20130101) C12N 2501/115 (20130101) C12N 2501/145 (20130101) C12N 2501/415 (20130101) C12N 2501/602 (20130101) C12N 2501/604 (20130101) C12N 2501/606 (20130101) C12N 2501/727 (20130101) C12N 2506/02 (20130101) C12N 2506/45 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 40/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220220461 | Czech et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael P. Czech (Westborough, Massachusetts); Emmanouela Tsagkaraki (Worcester, Massachusetts); Sarah M. Nicoloro (Holden, Massachusetts); Silvia Corvera (Westborough, Massachusetts) |
| ABSTRACT | Provided herein are methods and compositions for disrupting expression of nuclear receptor interacting protein 1 (Nrip1) in adipose cells, and methods of use of such adipose cells for treating, or reducing risk of, a condition associated with an elevated body mass index (BMI). |
| FILED | Friday, October 08, 2021 |
| APPL NO | 17/497367 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/35 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0653 (20130101) C12N 9/22 (20130101) Original (OR) Class C12N 15/11 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) C12N 2506/13 (20130101) C12N 2510/00 (20130101) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220220462 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David R. Liu (Cambridge, Massachusetts); Alexis Christine Komor (Cambridge, Massachusetts); Holly A. Rees (Cambridge, Massachusetts); Yongjoo Kim (Cambridge, Massachusetts) |
| ABSTRACT | Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a single site within the genome of a cell or subject, e.g., within the human genome. In some embodiments, fusion proteins of Cas9 and nucleic acid editing proteins or protein domains, e.g., deaminase domains, are provided. In some embodiments, methods for targeted nucleic acid editing are provided. In some embodiments, reagents and kits for the generation of targeted nucleic acid editing proteins, e.g., fusion proteins of Cas9 and nucleic acid editing proteins or domains, are provided. |
| FILED | Monday, November 15, 2021 |
| APPL NO | 17/527011 |
| CURRENT CPC | Peptides C07K 14/32 (20130101) C07K 2319/00 (20130101) C07K 2319/09 (20130101) C07K 2319/80 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 9/78 (20130101) C12N 9/2497 (20130101) C12N 15/11 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) Enzymes C12Y 305/04005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220220468 | SHEEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Volney SHEEN (Boston, Massachusetts); Gewei LIAN (Boston, Massachusetts) |
| ABSTRACT | Described are methods of homology directed repair (e.g., for treating a disease or disorder) and fusion proteins, polynucleotides (e.g., guide polynucleotides (e.g., guide RNAs) and polynucleotides encoding the fusion proteins), vectors containing the polynucleotides, viral or non-viral delivery vehicles containing the vectors, and compositions (e.g., pharmaceutical compositions) containing the same for use in methods of homology directed repair. |
| FILED | Friday, May 15, 2020 |
| APPL NO | 17/610360 |
| CURRENT CPC | Peptides C07K 2319/80 (20130101) C07K 2319/85 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/102 (20130101) Original (OR) Class C12N 15/907 (20130101) C12N 2310/20 (20170501) Enzymes C12Y 301/11003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220220469 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| INVENTOR(S) | Feng Zhang (Cambridge, Massachusetts); Han Altae-Tran (Cambridge, Massachusetts) |
| ABSTRACT | Described herein are non-Class I engineered CRISPR-Cas systems and components thereof, formulations thereof, cells thereof, and organisms thereof. Methods of making and using the CRISPR-Cas system described herein. |
| FILED | Wednesday, May 20, 2020 |
| APPL NO | 17/612245 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/102 (20130101) Original (OR) Class C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220220473 | Yeo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eugene Yeo (La Jolla, California); Frederick Tan (Encinitas, California) |
| ABSTRACT | Provided herein are compositions and methods for regulating protein translation. The compositions include a Cas polypeptide and a capped-sgRNA that includes (i) an m7G cap or an analog thereof; (ii) a spacer capable of specifically hybridizing with a target sequence in an RNA molecule; and (iii) a direct repeat capable of binding to the Cas polypeptide. The disclosure further provides methods of regulating translation of an mRNA in a cell, the method comprising contacting the cell with a nucleic acid comprising (a) a sequence encoding a Cas polypeptide; and (b) a sequence encoding a capped-sgRNA comprising (i) an m7G cap or analog thereof; (ii) a spacer capable of specifically hybridizing with a target sequence in an RNA molecule; and (iii) a direct repeat capable of binding to the Cas polypeptide. |
| FILED | Thursday, April 16, 2020 |
| APPL NO | 17/604128 |
| CURRENT CPC | Peptides C07K 2319/09 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/67 (20130101) C12N 15/111 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2310/317 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220220479 | Agarwal et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Children`s Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Suneet Agarwal (Lexington, Massachusetts); Diane Moon (Boxford, Massachusetts); Baris Boyraz (Cambridge, Massachusetts); Matthew Segal (Brookline, Massachusetts) |
| ABSTRACT | The disclosure relates to treating and diagnosing telomere diseases, and methods of screening agents for treating and diagnosing telomere diseases. |
| FILED | Tuesday, November 23, 2021 |
| APPL NO | 17/533950 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) A61K 31/7036 (20130101) A61K 31/7048 (20130101) A61K 31/7052 (20130101) A61K 38/005 (20130101) A61K 45/06 (20130101) Peptides C07K 16/40 (20130101) C07K 2319/00 (20130101) C07K 2319/80 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/16 (20130101) C12N 9/1241 (20130101) C12N 15/1137 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/14 (20130101) C12N 2310/20 (20170501) C12N 2310/122 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/136 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) Enzymes C12Y 207/07019 (20130101) C12Y 301/13004 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/573 (20130101) G01N 33/6893 (20130101) G01N 2333/91245 (20130101) G01N 2500/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220220482 | PENG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Saint Louis University (St. Louis, Missouri) |
| ASSIGNEE(S) | Saint Louis University (St. Louis, Missouri) |
| INVENTOR(S) | Guangyong PENG (St. Louis, Missouri); Xia LIU (St. Louis, Missouri) |
| ABSTRACT | The present disclosure provides compositions and methods for inhibiting T cell senescence and improving T cell immunotherapies. In particular, inhibitors of group IV A phospholipase A2 are disclosed as useful in modulating the lipid metabolism of cells, in particular effector T cells, such that T reg- and tumor cell-induced cell senescence is abrogated. These methods may be employed with particular utility in adoptive T cell therapies and/or enhanced T cell effector functions in vivo, including those performed in combination with checkpoint blockade therapies. |
| FILED | Tuesday, May 19, 2020 |
| APPL NO | 17/613130 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) A61K 35/17 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/505 (20130101) G01N 33/573 (20130101) G01N 33/5011 (20130101) G01N 2333/916 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220220484 | DALLAS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SomaGenics, Inc. (Santa Cruz, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anne DALLAS (Santa Cruz, California); Heini ILVES (Santa Cruz, California); Sumedha JAYASENA (Santa Cruz, California); Brian H. JOHNSTON (Santa Cruz, California) |
| ABSTRACT | Wound healing is a complex homeostatic process in which several distinct types coordinate to repair a physical damage. Failure to close wounds contributes to the pathology of conditions like diabetes mellitus, particularly in the elderly. Presented herein are molecules, pharmaceutical compositions, and methods for applying small RNA oligonucleotide technology to wound healing. Small RNA oligonucleotide approaches as disclosed herein provide a therapeutic strategy for improving both basal and pathological wound healing. |
| FILED | Monday, March 28, 2022 |
| APPL NO | 17/706234 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/02 (20180101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1131 (20130101) C12N 15/1137 (20130101) Original (OR) Class C12N 2310/317 (20130101) C12N 2310/3231 (20130101) Enzymes C12Y 114/11002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220220502 | Gradinaru et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Viviana Gradinaru (Pasadena, California); Sripriya Ravindra Kumar (Chennai, India); Benjamin Deverman (Boston, Massachusetts) |
| ABSTRACT | Provided are compositions and kits comprising recombinant adeno-associated viruses (rAAVs) with tropisms showing increased specificity and efficiency of viral transduction in targeted cell-types, for e.g., the brain and the liver. Therapeutic and bio-medical research applications of the rAAVs are also described, including without limitation methods of discovering rAAVs using a multiplexed Cre recombination-based AAV targeted evolution (M-CREATE) method, and methods of treating various diseases and conditions by rAAV-mediated transgene therapy. |
| FILED | Friday, April 10, 2020 |
| APPL NO | 17/602505 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 2750/14122 (20130101) C12N 2750/14143 (20130101) C12N 2750/14151 (20130101) C12N 2750/14171 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220220503 | Lipshutz |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Gerald Lipshutz (Los Angeles, California) |
| ABSTRACT | The invention disclosed herein provides methods and materials useful in gene therapy regimens designed to inhibit myelination abnormalities that occur in the urea cycle disorder arginase deficiency. The underlying cause of the progressive neurological dysfunction that occurs in this disorder has been previously unknown and conventional therapies, at best, only slow the onset of neurological dysfunction. This neurological dysfunction results at least in part from the dysmyelination that occurs in the central nervous system due to the lack of adequate hepatic expression of arginase 1. We have discovered an origin of this neurological dysfunction and, using this information, designed materials and associated methods of gene therapy. The methods and materials disclosed herein can inhibit and essentially prevent neurological dysfunction in a murine model of arginase deficiency. |
| FILED | Thursday, May 07, 2020 |
| APPL NO | 17/606583 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) A61K 48/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 2750/14143 (20130101) C12N 2830/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220220536 | Halvorsen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for the State University of New York (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenneth A. Halvorsen (Glenmont, New York); Lifeng Zhou (Albany, New York); Arun Richard Chandrasekaran (Albany, New York) |
| ABSTRACT | The present disclosure is directed to a nucleic acid, including: a DNA nanoswitch-nucleic acid complex including a deoxyribonucleic acid (DNA) nanoswitch and a ribonucleic acid binding site, wherein the DNA nanoswitch has a first conformation characterized as open, and a second conformation characterized as closed when in a presence of ribonucleic acid-of-interest. DNA nanoswitches that hybridize to preselected viral RNA are also disclosed, as well as methods of detecting or identifying an RNA virus, and kits related thereto. |
| FILED | Tuesday, January 11, 2022 |
| APPL NO | 17/573529 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6809 (20130101) Original (OR) Class C12Q 1/6837 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220220551 | Philibert |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Behavioral Diagnostics, LLC (Coralville, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Philibert (Iowa City, Iowa) |
| ABSTRACT | This disclosure relates to differentially methylated regions (DMRs) and an equation that can be applied when using epigenetic analysis in a biological sample that includes more than one cell type and, therefore, more than one methylation set point (e.g., saliva). This disclosure relates to differentially methylated regions (DMRs) and an equation that can be applied when using epigenetic analysis in a biological sample that includes more than one cell type and, therefore, more than one methylation set point (e.g., saliva). |
| FILED | Wednesday, April 22, 2020 |
| APPL NO | 17/605019 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6858 (20130101) Original (OR) Class C12Q 1/6881 (20130101) C12Q 2600/154 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220220556 | Khatri et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Purvesh Khatri (Menlo Park, California); Timothy E. Sweeney (San Francisco, California) |
| ABSTRACT | This disclosure provides a gene expression-based method for determining whether a subject having sepsis has an Inflammopathic phenotype, an Adaptive phenotype or a Coagulopathic phenotype. A kit for performing the method is also provided. |
| FILED | Monday, January 28, 2019 |
| APPL NO | 16/969923 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/16 (20130101) C12Q 2600/112 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220220563 | Vogelstein et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bert Vogelstein (Baltimore, Maryland); Kenneth W. Kinzler (Baltimore, Maryland); Luis Diaz (Ellicot City, Maryland); Nickolas Papadopoulos (Towson, Maryland); Nishant Agrawal (Baltimore, Maryland); Yuxuan Wang (Baltimore, Maryland); Simeon Springer (Baltimore, Maryland) |
| ABSTRACT | We queried DNA from saliva or plasma of 93 HNSCC patients, searching for somatic mutations or human papillomavirus genes, collectively referred to as tumor DNA. When both plasma and saliva were tested, tumor DNA was detected in 96% (95% CI, 84% to 99%) of 47 patients. The fractions of patients with detectable tumor DNA in early- and late-stage disease were 100% (n=10) and 95% (n=37), respectively. Saliva is preferentially enriched for tumor DNA from the oral cavity, whereas plasma is preferentially enriched for tumor DNA from the other sites. Tumor DNA in the saliva and plasma is a valuable biomarker for detection of HNSCC. |
| FILED | Thursday, January 27, 2022 |
| APPL NO | 17/586101 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/112 (20130101) C12Q 2600/118 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220220566 | WEI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Jackson Laboratory (Bar Harbor, Maine) |
| ASSIGNEE(S) | The Jackson Laboratory (Bar Harbor, Maine) |
| INVENTOR(S) | Chia-Lin WEI (Farmington, Connecticut); Chee Hong WONG (Farmington, Connecticut); Harianto TJONG (Farmington, Connecticut); Roel VERHAAK (Farmington, Connecticut) |
| ABSTRACT | The invention, in part, encompasses methods to identify extrachromosomal circular DNA (ecDNA) and methods to identify and assess interactions between ecDNA and oncogene transcription. |
| FILED | Wednesday, April 29, 2020 |
| APPL NO | 17/607635 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6841 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220220664 | Akilavasan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Agienic Inc. (Tucson, Arizona) |
| ASSIGNEE(S) | Agienic Inc. (Tucson, Arizona) |
| INVENTOR(S) | Jeganathan Akilavasan (Tucson, Arizona); Kyler Novotony (Tucson, Arizona); Anoop Agrawal (Tucson, Arizona); Donald R. Uhlmann (Tucson, Arizona) |
| ABSTRACT | Aqueous formulations containing antimicrobial materials dispersed in solutions or emulsions, methods of their preparation, application of such compositions to surfaces, and their resulting coatings. Coating of hydrophobic surfaces with aqueous solutions or suspensions containing antimicrobial materials are disclosed. Several applications of the antimicrobial coatings are described including the coating of solid and porous substrates such as fabrics which may be used for gowns, masks, and other personal protection equipment. |
| FILED | Friday, January 07, 2022 |
| APPL NO | 17/571143 |
| CURRENT CPC | Outerwear; Protective Garments; Accessories A41D 13/12 (20130101) Treating Textile Materials Using Liquids, Gases or Vapours D06B 1/02 (20130101) Treatment, Not Provided for Elsewhere in Class D06, of Fibres, Threads, Yarns, Fabrics, Feathers or Fibrous Goods Made From Such Materials D06M 11/13 (20130101) Original (OR) Class D06M 15/564 (20130101) D06M 2101/32 (20130101) D06M 2200/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220221335 | ARBAB et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Research Foundation for The State University of New York (Albany, New York) |
| ASSIGNEE(S) | The Research Foundation for The State University of New York (Albany, New York) |
| INVENTOR(S) | Mohammad Hassan ARBAB (South Setauket, New York); Zachery HARRIS (Stony Brook, New York) |
| ABSTRACT | Handheld, broadband terahertz (THz) scanners, housings therefor and imaging systems are provided. The scanner may comprise a 2-Dimensional (2D) gimbaled mirror for beam steering. The 2D gimbaled mirror may comprise a single minor mounted in a frame, a first motor and a second motor. The first motor and the second motor may be coupled to the frame. The minor may be rotatable in a first axis of rotation and a second axis of rotation to scan light on a target in two dimensions. The first motor corresponds to the first axis and the second motor corresponding to the second axis. The 2D gimbaled mirror may be positioned within the housing such that the single mirror is positioned at a focus of a focusing lens. The focusing lens may be fixed within a housing. The scanner may also comprise a terahertz emitter and detector. |
| FILED | Wednesday, March 11, 2020 |
| APPL NO | 17/438630 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/021 (20130101) Original (OR) Class G01J 3/0208 (20130101) G01J 3/0272 (20130101) G01J 3/0291 (20130101) G01J 2003/062 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/3586 (20130101) G01N 2201/0221 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220221442 | Ouyang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zheng Ouyang (West Lafayette, Indiana); He Wang (West Lafayette, Indiana); Nicholas E. Manicke (West Lafayette, Indiana); Robert Graham Cooks (West Lafayette, Indiana); Qian Yang (West Lafayette, Indiana); Jiangjiang Liu (West Lafayette, Indiana) |
| ABSTRACT | The invention generally relates to a sample dispenser including an internal standard and methods of use thereof. |
| FILED | Tuesday, January 25, 2022 |
| APPL NO | 17/584100 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/10 (20130101) G01N 1/28 (20130101) G01N 1/286 (20130101) G01N 33/491 (20130101) G01N 33/492 (20130101) Original (OR) Class G01N 33/48714 (20130101) G01N 33/48785 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/0009 (20130101) H01J 49/16 (20130101) H01J 49/0027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220221537 | Conolly et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Steven M. Conolly (Palo Alto, California); Patrick W. Goodwill (San Francisco, California); Daniel Hensley (Berkeley, California); Zhi Wei Tay (Berkeley, California); Bo Zheng (Berkeley, California) |
| ABSTRACT | A pulsed magnetic particle imaging system includes a magnetic field generating system that includes at least one magnet, the magnetic field generating system providing a spatially structured magnetic field within an observation region of the magnetic particle imaging system such that the spatially structured magnetic field will have a field-free region (FFR) for an object under observation having a magnetic nanoparticle tracer distribution therein. The pulsed magnetic particle imaging system also includes a pulsed excitation system arranged proximate the observation region, the pulsed excitation system includes an electromagnet and a pulse sequence generator electrically connected to the electromagnet to provide an excitation waveform to the electromagnet, wherein the electromagnet when provided with the excitation waveform generates an excitation magnetic field within the observation region to induce an excitation signal therefrom by at least one of shifting a location or condition of the FFR. The pulsed magnetic particle imaging system further includes a detection system arranged proximate the observation region, the detection system being configured to detect the excitation signal to provide a detection signal. The excitation waveform includes a transient portion and a substantially constant portion. |
| FILED | Friday, January 21, 2022 |
| APPL NO | 17/581684 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/10 (20130101) G01R 33/1276 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220221540 | Fair et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Merlin John Casper Fair (Boston, Massachusetts); Kawin Setsompop (Charlestown, Massachusetts) |
| ABSTRACT | Magnetic resonance imaging (“MRI”) using a PROPELLER echo-planar time-resolved imaging with dynamic encoding (“PEPTIDE”) scheme is described. The PEPTIDE scheme combines a PROPELLER-style trajectory with an echo-planar time-resolved imaging (“EPTI”) acquisition framework, along with dynamic-updating of sensitivity-encoding information. |
| FILED | Thursday, March 26, 2020 |
| APPL NO | 17/442823 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 2560/0223 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/4824 (20130101) Original (OR) Class G01R 33/5608 (20130101) G01R 33/56509 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220222781 | Jacob et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Iowa Research Foundation (Iowa City, Iowa) |
| ASSIGNEE(S) | University of Iowa Research Foundation (Iowa City, Iowa) |
| INVENTOR(S) | Mathews Jacob (Iowa City, Iowa); Qing Zou (Iowa City, Iowa) |
| ABSTRACT | A method for visualization of dynamic objects using a generative manifold includes steps of: acquiring a set of measurements associated with the dynamic objects using sensors; estimating parameters of a generator using the set of measurements and estimating latent variables using the set of measurements; modeling using a computing device the dynamic objects as a smooth non-linear function of the latent variables using the generator such that points in a latent subspace are mapped to a manifold in a generative manifold model; and generating a visualization of the dynamic objects using the generative manifold model. The set of measurements may include multi-slice data. The generative manifold model may provide for modeling deformations. |
| FILED | Tuesday, January 11, 2022 |
| APPL NO | 17/573047 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Image Data Processing or Generation, in General G06T 5/002 (20130101) Original (OR) Class G06T 5/50 (20130101) G06T 2207/10076 (20130101) G06T 2207/10088 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/20182 (20130101) G06T 2207/30048 (20130101) G06T 2207/30061 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220223225 | do Valle et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Italo Faria do Valle (Boston, Massachusetts); Albert-László Barábasi (Brookline, Massachusetts); Peter Ruppert (Chestnut Hill, Massachusetts) |
| ABSTRACT | Systems and methods of identifying a disease associated with a therapeutic chemical are presented. A method includes generating a candidate disease list based on proximities of proteins associated with a plurality of diseases and proteins associated with a therapeutic chemical in a protein-protein interaction network. The method further includes applying gene expression information associated with the therapeutic chemical to generate enrichment scores for diseases of the candidate disease list and identifying at least one disease associated with the therapeutic chemical based on the determined enrichment scores. |
| FILED | Friday, May 22, 2020 |
| APPL NO | 17/595185 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) Original (OR) Class G16B 25/10 (20190201) G16B 40/10 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 70/60 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220223257 | Akbari et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yama Akbari (Irvine, California); Matine Azadian (Irvine, California); Robert H. Wilson (Irvine, California) |
| ABSTRACT | Systems and methods for generating neuroprotective and cardioprotective nutrition programs are described herein. These neuroprotective and cardioprotective nutrition programs are especially applicable for patients at risk of cardiac arrest (e.g. due to hypoxia or ischemia of the brain or other body parts). The programs may feature caloric restriction, for example, short-term caloric restriction. The programs may be generated or iteratively modified based on the hemodynamic and metabolic state of the patient's brain, limbs, or other tissues or organs. Dynamic feedback about the patient's hemodynamic and metabolic state may be provided by techniques including, but not limited to, optical technology for quantitatively and noninvasively measuring blood flow, oxygenation, metabolic rate of oxygen, and perfusion/metabolism ratio in the brain, limbs, or other tissues or organs. The systems described herein may also induce spreading depolarization and repolarization at specific times during or after cardiac arrest based on the patient's cerebral metabolic state. |
| FILED | Monday, March 28, 2022 |
| APPL NO | 17/706217 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4866 (20130101) A61B 5/7275 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/60 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220223394 | WESTPHALL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Scott WESTPHALL (Fitchburg, Wisconsin); Joshua Jacques COON (Middleton, Wisconsin) |
| ABSTRACT | Imaging by cryo-electron microscopy (cryo-EM) requires that a sample be encased in an amorphous solid, such as amorphous ice. In current cryo-EM preparation systems, once the sample has been deposited on an EM grid and coated in the amorphous solid, the EM grid must be removed from vacuum and then transferred into the vacuum of the cryo-EM system. As a result, samples deposited on the grid are exposed to damage and contamination. The present invention provides improved EM grid handling systems and devices compatible with advanced cryo-EM sample preparation techniques and which reduce or eliminate exposure of the sample on the grid to atmosphere and elevated temperatures. These methods and devices will also significantly reduce handling time and complexities associated with cryo-EM sample preparation. |
| FILED | Thursday, January 13, 2022 |
| APPL NO | 17/575135 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/42 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/0004 (20130101) Original (OR) Class H01J 49/062 (20130101) H01J 49/0486 (20130101) H01J 49/0495 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20220218265 | SHEPARD et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenneth L. SHEPARD (Ossining, New York); Sajjad MOAZENI (New York, New York); Eric POLLMANN (New York, New York) |
| ABSTRACT | Exemplary embodiments of the present disclosure provide for an integrated, flexible, implantable, optical neural interrogation apparatus, computer-accessible medium, system, and method for use thereof An integrated, flexible, fully-implantable, all-optical neural interrogation apparatus can include, e.g., a 2-dimensional (2D) planar array of optical photodetectors on an integrated electronic chip, the integrated electronic chip including control logic and image-capturing electronic circuitry, an amplitude or phase optical imaging mask for imaging, and a biocompatible packaging. |
| FILED | Monday, January 24, 2022 |
| APPL NO | 17/582375 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0071 (20130101) A61B 5/0084 (20130101) A61B 5/4064 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/173 (20130101) H01L 31/03926 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220218500 | SHEPHERD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cornell University (lthaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert F. SHEPHERD (Ithaca, New York); James PIKUL (Philadelphia, Pennsylvania) |
| ABSTRACT | The present disclosure provides an electrohydraulic device. The device includes a battery having a vessel containing a flowable electrolyte. The battery may be a flow cell battery, such as, for example, a redox flow cell battery. In a flow cell battery, the flowable electrolyte may a catholyte and/or an anolyte. An actuator is in fluidic communication with the vessel of the battery. The actuator is configured to be actuated using the flowable electrolyte. A cation exchange membrane may separate the vessel into an anolyte side and a catholyte side. The actuator may be in fluidic communication with either side (anolyte side or catholyte side) of the vessel. |
| FILED | Thursday, April 23, 2020 |
| APPL NO | 17/605996 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/74 (20210801) Original (OR) Class A61F 2/586 (20130101) Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 1/0288 (20130101) A61H 3/00 (20130101) A61H 2201/1238 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/188 (20130101) H01M 8/04186 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220218668 | Bai et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Haiqing Bai (Cambridge, Massachusetts); Longlong Si (Cambridge, Massachusetts); Rachelle Prantil-Baun (Cambridge, Massachusetts); Donald E. Ingber (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure provides compositions and methods for inhibiting respiratory viral infections, inflammatory diseases, and/or respiratory inflammation. |
| FILED | Friday, February 11, 2022 |
| APPL NO | 17/669595 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/417 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/02 (20180101) A61P 31/12 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220218722 | MOHLER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Health Research, Inc. (Buffalo, New York); University of Kentucky Research Foundation (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James L. MOHLER (Buffalo, New York); Michael V. FIANDALO (Buffalo, New York); David WATT (Lexington, Kentucky); Vitaliy SVIRIPA (Frederick, Maryland) |
| ABSTRACT | Provided are androstane and dihydrotestosterone compounds functionalized with carbocyclic groups or heterocyclic groups that may be saturated or unsaturated. The compounds may be used in methods of inhibiting cell growth of malignant cells and/or hyperplastic cells and/or treating individuals having diseases associated with malignant cell growth (e.g., cancer, such as, for example, prostate cancer) and/or hyperplastic cell growth and/or molecular imaging of malignant cells and/or hyperplastic cells and/or inducing degradation of a target protein. Also provided are compositions. |
| FILED | Monday, April 27, 2020 |
| APPL NO | 17/606998 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/58 (20130101) A61K 31/167 (20130101) A61K 31/277 (20130101) A61K 31/496 (20130101) A61K 31/585 (20130101) Original (OR) Class A61K 31/4155 (20130101) A61K 31/4166 (20130101) A61K 31/4439 (20130101) A61K 49/0002 (20130101) Steroids C07J 43/003 (20130101) C07J 43/006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220218752 | BAKER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington); FRED HUTCHINSON CANCER RESEARCH CENTER (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David BAKER (Seattle, Washington); Scott BOYKEN (Seattle, Washington); Marc Joseph LAJOIE (Seattle, Washington); Robert A. LANGAN (Seattle, Washington); Stanley R. RIDDELL (Seattle, Washington); Alexander SALTER (Seattle, Washington) |
| ABSTRACT | Disclosed are protein switches that can sequester bioactive peptides and/or binding domains, holding them in an inactive (“off”) state, until combined with a second designed polypeptide called the key, which induces a conformational change that activates (“on”) the bioactive peptide or binding domain only when the protein switch components are co/localized when bound to their targets, components of such protein switches, and their use. |
| FILED | Monday, May 18, 2020 |
| APPL NO | 17/610083 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 38/1774 (20130101) Peptides C07K 14/005 (20130101) C07K 14/4747 (20130101) C07K 14/7051 (20130101) C07K 14/70596 (20130101) C07K 2319/30 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 15/86 (20130101) C12N 15/625 (20130101) C12N 2501/2302 (20130101) C12N 2510/00 (20130101) C12N 2740/15043 (20130101) C12N 2800/107 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220218762 | Hsiao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of The University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elaine Y. Hsiao (Los Angeles, California); Christine Olson (Los Angeles, California); Alonso Iniguez (Los Angeles, California) |
| ABSTRACT | The present disclosure provides methods of treating hypoxia-induced cognitive impairment. Also disclosed are microbiome modulators, such as ketogenic-diet-suppressed bacterial species or antibiotics effective against a ketogenic-diet-boosted bacterial species, for use in treatment of cognitive impairment. The disclosure also provides methods of selecting a subject having hypoxia-induced cognitive impairment and methods of obtaining a prognostic indicator of hypoxia-induced cognitive impairment in a subject who receives a dosage of a microbiome modulator. |
| FILED | Monday, June 01, 2020 |
| APPL NO | 17/615297 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/74 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Peptides C07K 16/244 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220218808 | Sayour et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elias Sayour (Newberry, Florida); James Andrew McGuiness (Gainesville, Florida); Hector Ruben Mendez-Gomez (Gainesville, Florida); Duane A. Mitchell (Gainesville, Florida) |
| ABSTRACT | Provided herein are compositions comprising a liposome comprising RNA molecules and a cationic lipid, wherein the RNA molecules encode at least one MHC Class II epitope of a mutant Histone 3 (H3) protein comprising a K27M mutation and optionally at least one MHC Class I epitope of the mutant H3 protein. In exemplary embodiments, the RNA molecules comprise a sequence of SEQ ID NO: 12 or 14. Methods of increasing central memory T cells, increasing an immune response, or treating a diffuse midline glioma (DMG), in a subject are provided herein. In exemplary embodiments, the methods comprise administering to the subject the compositions provided herein. |
| FILED | Friday, May 01, 2020 |
| APPL NO | 17/607495 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/001114 (20180801) Original (OR) Class A61K 2039/53 (20130101) A61K 2039/80 (20180801) A61K 2039/55555 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/70539 (20130101) C07K 14/70596 (20130101) C07K 2319/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220218825 | Eisenbrey et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Drexel University (Philadelphia, Pennsylvania); Thomas Jefferson University (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | Drexel University (Philadelphia, Pennsylvania); Thomas Jefferson University (Philadelphia, Pennsylvania) |
| INVENTOR(S) | John Robert Eisenbrey (Philadelphia, Pennsylvania); Margaret Alison Wheatley (Media, Pennsylvania); Patrick O'Kane (Philadelphia, Pennsylvania); Lorenzo Albala (Philadelphia, Pennsylvania); Flemming Forsberg (Lafayette Hill, Pennsylvania) |
| ABSTRACT | The invention relates to an ultrasound contrast agent (UCA) comprising an outer shell and a gas core. The gas core is filled with oxygen, and the outer shell comprises a first surfactant and a second surfactant. The invention also relates to a method of making an oxygen-filled UCA and delivering oxygen to a local area of a subject's body. The method comprises injecting a composition comprising an oxygen-filled UCA of the invention into the subject's body; directing ultrasound radiation to the local area in an intensity sufficient to rupture the UCA. |
| FILED | Tuesday, March 29, 2022 |
| APPL NO | 17/657028 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0009 (20130101) A61K 33/00 (20130101) A61K 41/0028 (20130101) Original (OR) Class A61K 41/0038 (20130101) A61K 49/223 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 2005/1098 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220218827 | Kaittanis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Memorial Sloan Kettering Cancer Center (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charalambos Kaittanis (New York, New York); Jan Grimm (New York, New York) |
| ABSTRACT | The present technology relates to the field of drug delivery. For example, the present technology provides methods of delivering a therapeutic to a cell where the method includes administering to a cancer cell a drug delivery composition. In this exemplary method, the drug deliver composition includes a (super)paramagnetic iron oxide nanoparticle core, where the nanoparticle core includes a coat non-covalently attached to a therapeutic, and the coat includes at least one of poly(acrylic acid), carboxymethyl dextran, and polyglucose sorbitol carboxymethylether. |
| FILED | Friday, August 20, 2021 |
| APPL NO | 17/408292 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/52 (20130101) A61K 31/506 (20130101) A61K 31/663 (20130101) A61K 31/704 (20130101) A61K 31/4166 (20130101) A61K 31/4745 (20130101) A61K 31/5377 (20130101) A61K 45/06 (20130101) Original (OR) Class A61K 47/58 (20170801) A61K 47/61 (20170801) A61K 47/585 (20170801) A61K 47/6923 (20170801) A61K 47/6929 (20170801) A61K 49/1854 (20130101) A61K 49/1863 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/50 (20130101) G01R 33/5601 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220219171 | Siltanen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); Scribe Biosciences Inc. (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christian Siltanen (San Francisco, California); Russell Cole (San Francisco, California); Adam R. Abate (Daly City, California); Justin Madrigal (San Francisco, California); Maithreyan Srinivasan (Palo Alto, California) |
| ABSTRACT | Methods for selectively combining discrete entities including, e.g. cells, reagents, drugs, hydrogels, extracellular matrices beads, particles, biological materials, media, or a combination thereof, are provided. In certain aspects, the methods include sorting a plurality of discrete entities and trapping two or more discrete entities for a time sufficient for the two or more discrete entities to combine to form a combined discrete entity. In certain aspects, the methods include making the plurality of discrete entities. In certain aspects, the methods include detecting or analyzing the discrete entities, e.g. via optical detection. In certain aspects, the methods include manipulating or analyzing the combined discrete entity or a component therein, e.g. imaging, sequencing, culturing, e.g., three-dimensional culturing, and measuring cell-cell interactions. Systems and devices for practicing the subject methods are also provided. |
| FILED | Wednesday, May 13, 2020 |
| APPL NO | 17/595054 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) Original (OR) Class B01L 2200/10 (20130101) B01L 2200/16 (20130101) B01L 2200/025 (20130101) B01L 2200/0636 (20130101) B01L 2200/0652 (20130101) B01L 2200/0673 (20130101) B01L 2300/0663 (20130101) B01L 2300/0864 (20130101) B01L 2400/086 (20130101) B01L 2400/0638 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220219239 | Elwany et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alaa Elwany (College Station, Texas); Ibrahim Karaman (College Station, Texas); Raymundo Arroyave (College Station, Texas); Raiyan Seede (College Station, Texas); Bing Zhang (College Station, Texas); Luke Johnson (College Station, Texas) |
| ABSTRACT | A method for determining alloy processing parameters is provided. Simulated melt pool temperature and melt pool geometries can be used to create an initial printability map based on laser speed and laser power, and the printability map can include regions with potential manufacturing defects. Single-track experiments can be used to calibrate the printability map, to produce a revised printability map. Finally, contour lines representing hatch spacing can also be added to the revised printability map to produce a final printability map that can be used to configure additive manufacturing machinery. |
| FILED | Wednesday, October 13, 2021 |
| APPL NO | 17/500004 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/80 (20210101) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 30/00 (20141201) B33Y 50/00 (20141201) Electric Digital Data Processing G06F 30/20 (20200101) G06F 2113/10 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220219340 | Farritor et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shane Farritor (Lincoln, Nebraska); Thomas Frederick (Lincoln, Nebraska) |
| ABSTRACT | The various embodiments herein relate to a coupling apparatus for a medical device having a coupler body, a cavity defined in the coupler body, a rotatable drive component disposed within the cavity and having at least two pin-receiving openings, and an actuable locking ring disposed around the cavity. |
| FILED | Monday, October 18, 2021 |
| APPL NO | 17/503456 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/00234 (20130101) A61B 34/30 (20160201) A61B 34/70 (20160201) Manipulators; Chambers Provided With Manipulation Devices B25J 15/0408 (20130101) B25J 19/0029 (20130101) Original (OR) Class Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors H01R 13/005 (20130101) H01R 13/24 (20130101) H01R 13/625 (20130101) H01R 24/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220219795 | Ripplinger et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BATTLE SIGHT TECHNOLOGIES, LLC (Dayton, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas R. Ripplinger (Dayton, Ohio); David Charles Di Staulo (Dayton, Ohio); Sunny L. Kapka (Dayton, Ohio); Grant David Santo (Dayton, Ohio); Jay Phillip-Donald Vallie (Dayton, Ohio); Christopher J. Vogt (Dayton, Ohio); Colton A. Whitman (Dayton, Ohio) |
| ABSTRACT | An apparatus that facilitates search and rescue, for example, in open water. The apparatus comprises a substrate with a particular geometry and a perimeter. The apparatus further comprises a cover positioned atop the substrate with the cover also having a particular geometry and perimeter, which correspond to the geometry and perimeter of the substrate. An air-tight seal seals the substrate perimeter to the cover perimeter and creates a sealed internal region. A liquid-releasable vessel holding an illuminable dye located in the sealed internal region, along with an activator that is also located in the sealed internal region. When the liquid-releasable vessel releases the illuminable dye, the illuminable dye reacts with the activator, thereby resulting in illumination of the illuminable dye. The liquid-releasable vessel comprises an opening with a release mechanism (e.g., clamp, etc.). |
| FILED | Wednesday, January 13, 2021 |
| APPL NO | 17/147527 |
| CURRENT CPC | Ships or Other Waterborne Vessels; Equipment for Shipping B63B 2201/04 (20130101) B63B 2201/22 (20130101) Launching, Hauling-out, or Dry-docking of Vessels; Life-saving in Water; Equipment for Dwelling or Working Under Water; Means for Salvaging or Searching for Underwater Objects B63C 9/00 (20130101) Original (OR) Class Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/07 (20130101) Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 5/002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220220154 | ALVAREZ |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Theradaptive, Inc. (Frederick, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Luis ALVAREZ (Lexington, Massachusetts) |
| ABSTRACT | Provided herein are polypeptides that include one or more β-tricalcium phosphate (βTCP)-binding sequence(s) and uses thereof. |
| FILED | Wednesday, October 20, 2021 |
| APPL NO | 17/506523 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/04 (20130101) A61K 38/16 (20130101) A61K 38/1875 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/00 (20180101) Peptides C07K 7/08 (20130101) Original (OR) Class C07K 14/001 (20130101) C07K 14/51 (20130101) C07K 14/475 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220220156 | Taylor et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rebecca Taylor (Pittsburgh, Pennsylvania); Sriram Kumar (Pittsburgh, Pennsylvania); Dilhara R. Jayarathna (Cincinnati, Ohio) |
| ABSTRACT | Provided herein are single-stranded tile (SST) structures prepared from and comprising single-stranded γPNA (ss-γPNA) strands, along with methods of making an SST structure from single-stranded γPNA (ss-γPNA) strands. |
| FILED | Friday, March 27, 2020 |
| APPL NO | 17/599423 |
| CURRENT CPC | Peptides C07K 14/003 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6813 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/533 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220220168 | Barnes et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH (Manhasset, New York) |
| ASSIGNEE(S) | THE FEINSTEIN INSTITUES FOR MEDICAL RESEARCH (Manhasset, New York) |
| INVENTOR(S) | Betsy J. Barnes (Glenwood Landing, New York); Shan Sun (Wingdale, New York) |
| ABSTRACT | Polypeptides comprising a cell penetrating amino acid sequence and an interferon regulatory factor 5 (IRF5) targeting amino acid sequence are disclosed, where the IRF5 targeting amino acid sequence is one or more of RHATRHG (SEQ ID NO:1), KSRDFRL (SEQ ID NO:2) and GPRDMPP (SEQ ID NO:3), as well as methods of using these polypeptides to treat diseases, such as autoimmune and inflammatory diseases. |
| FILED | Monday, May 04, 2020 |
| APPL NO | 17/608487 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/00 (20180101) Peptides C07K 14/47 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220220268 | Ghiassi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kamran B. Ghiassi (Palmdale, California); Neil D. Redeker (Lancaster, California); Alexander T. Lonnecker (Lancaster, California); Jayden N. Glover (Fort Collins, Colorado) |
| ABSTRACT | The present invention relates to a microfluidic flow process for making monomers, monomers made by such processes, and methods of using such monomers. In such process, microfluidic reaction technology is used to synthesize cyanation reaction products orders of magnitude faster than is possible in batch and continuous syntheses. The aforementioned process does require strictly regulated, highly toxic cyanogen chloride. Thus the aforementioned process is more economically efficient and reduces the environmental impact of thermosetting resin monomer production, and produces thermosetting resin monomers in greater purity than obtained through typical processes. |
| FILED | Monday, March 28, 2022 |
| APPL NO | 17/705534 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/0093 (20130101) Acyclic or Carbocyclic Compounds C07C 261/02 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 73/065 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/24 (20130101) Original (OR) Class C08J 2379/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220220372 | Rand et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF PRINCETON UNIVERSITY (Princeton, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Barry Rand (Princeton, New Jersey); Ross Kerner (Princeton, New Jersey); Zhengguo Xiao (Plainsboro, New Jersey) |
| ABSTRACT | Organic-inorganic perovskite nanoparticle compositions are described herein. In some embodiments, a nanoparticle composition comprises a layer of organic-inorganic perovskite nanocrystals, the organic-inorganic perovskite nanocrystals comprising surfaces associated with ligands of size unable to incorporate into octahedral corner sites of the perovskite crystal structure. |
| FILED | Wednesday, September 08, 2021 |
| APPL NO | 17/469429 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) Original (OR) Class C09K 11/025 (20130101) Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 7/14 (20130101) C30B 29/12 (20130101) C30B 29/60 (20130101) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 9/2009 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0077 (20130101) H01L 51/4253 (20130101) H01L 51/5032 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220220437 | Levin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts); University of Vermont (Burlington, Vermont) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Levin (Beverly, Massachusetts); Douglas J. Blackiston (Medford, Massachusetts); Kelly A. McLaughlin (Medford, Massachusetts); Josh Bongard (Jericho, Vermont); Sam Kriegman (Burlington, Vermont) |
| ABSTRACT | Disclosed are engineered multicellular organisms. The disclosed organisms comprise an aggregate of ciliated cells, and the organisms move when the ciliated cells are actuated. The engineered multicellular organisms also are capable of kinematic self-replication. The engineered multicellular organisms are capable of moving a plurality of dissociated ciliated cells into piles of ciliated cells which form a multicellular organism comprising an aggregate of ciliated cells which moves when the ciliated cells are actuated. Also disclosed are systems and methods for designing, preparing, and utilizing the engineered multicellular organisms. |
| FILED | Wednesday, January 12, 2022 |
| APPL NO | 17/647847 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) C12M 23/16 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220220461 | Czech et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael P. Czech (Westborough, Massachusetts); Emmanouela Tsagkaraki (Worcester, Massachusetts); Sarah M. Nicoloro (Holden, Massachusetts); Silvia Corvera (Westborough, Massachusetts) |
| ABSTRACT | Provided herein are methods and compositions for disrupting expression of nuclear receptor interacting protein 1 (Nrip1) in adipose cells, and methods of use of such adipose cells for treating, or reducing risk of, a condition associated with an elevated body mass index (BMI). |
| FILED | Friday, October 08, 2021 |
| APPL NO | 17/497367 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/35 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0653 (20130101) C12N 9/22 (20130101) Original (OR) Class C12N 15/11 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) C12N 2506/13 (20130101) C12N 2510/00 (20130101) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220220514 | Lynch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael David Lynch (Durham, North Carolina); Zhixia Ye (Raleigh, North Carolina) |
| ABSTRACT | The present disclosure provides compositions and methods for rapid production of chemicals in genetically engineered microorganisms in a large scale. Also provided herein is a high-throughput metabolic engineering platform enabling the rapid optimization of microbial production strains. The platform, which bridges a gap between current in vivo and in vitro bio-production approaches, relies on dynamic minimization of the active metabolic network. |
| FILED | Friday, January 14, 2022 |
| APPL NO | 17/576290 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/001 (20130101) C12N 9/0006 (20130101) C12N 9/0008 (20130101) C12N 9/0016 (20130101) C12N 9/0051 (20130101) C12N 9/1025 (20130101) C12N 15/746 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/42 (20130101) Original (OR) Class C12P 13/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220220521 | Terrell et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | U.S. Army Combat Capabilities Development Command, Army Research Labortary (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jessica L. Terrell (Philadelphia, Pennsylvania); Justin P. Jahnke (Bethesda, Maryland) |
| ABSTRACT | A biofabrication method for producing cellulose-based materials. The method includes providing active cellulose-producing bacteria such as Gluconacetobacter and culturing media in a container; combining organic additives or inorganic additives with the active cellulose-producing bacteria in the container to produce a cellulose hydrogel matrix composed of entangled bacteria-produced cellulose nanofibers; controlling a concentration of the additives in the cellulose hydrogel matrix; and exposing the cellulose hydrogel matrix in selected thermal environment to create a biofabricated functional material. |
| FILED | Thursday, January 14, 2021 |
| APPL NO | 17/148720 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 35/0033 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/05 (20170801) Compositions of Macromolecular Compounds C08L 1/02 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220220855 | Hayek et al. |
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| FUNDED BY |
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| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Elia Hayek (Wrentham, Massachusetts); Victor Hugo Silva Correia (Milton Mills, New Hampshire) |
| ABSTRACT | An airfoil for a gas turbine engine defining a radial direction and an axial direction, the airfoil including: a flared portion extending from a suction surface of the airfoil at an outer edge of the airfoil along the radial direction; and a plenum disposed at the outer edge of the airfoil, the plenum having a suction-side sidewall and a pressure-side sidewall, wherein the suction-side sidewall has a first sidewall portion adjacent to a second sidewall portion disposed outside of the first sidewall portion along the radial direction, wherein the first sidewall portion defines a first angle, wherein the second sidewall portion defines a second angle, and wherein the first angle is greater than the second angle. |
| FILED | Wednesday, January 13, 2021 |
| APPL NO | 17/148156 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/186 (20130101) Original (OR) Class F01D 25/12 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2240/30 (20130101) F05D 2260/202 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220221234 | ZUBIN et al. |
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| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Jacob ZUBIN (West Lafayette, Indiana); Xueji WANG (West Lafayette, Indiana); Ali JISHI (West Lafayette, Indiana); Avra Sankar BANDYOPADHYAY (West Lafayette, Indiana) |
| ABSTRACT | A thermal dual-barrier coating system is disclosed which includes a first thermal barrier layer having a first thermal conductivity, one or more composite structures vertically disposed adjacent the first thermal barrier layer, each of the one or more composite structures includes an ultra-thin disordered semi-continuous metallic film and a layer of a second thermal barrier layer. |
| FILED | Tuesday, January 11, 2022 |
| APPL NO | 17/573558 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/14 (20130101) C23C 14/30 (20130101) C23C 14/083 (20130101) C23C 14/3464 (20130101) Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 13/185 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220221277 | Lee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| INVENTOR(S) | Wonjae Lee (Princeton, New Jersey); Michael Romalis (Princeton, New Jersey); Vito Giovanni Lucivero (Barcelona, Spain); Mark Limes (Princeton, New Jersey); Elizabeth Foley (Plainsboro, New Jersey); Tom Kornack (Plainsboro, New Jersey) |
| ABSTRACT | According to various embodiments, a method for reducing heading error in a magnetometer that uses Rb-87 atoms is disclosed. The method includes varying a direction and magnitude of a magnetic field at different spin polarization regimes. According to various embodiments, a magnetometer adapted for reduced heading error is disclosed. The magnetometer includes a multipass cell containing Rb-87 vapor, a pump laser operated in a pulse mode that is synchronous with a Larmor frequency, and two orthogonal probe lasers configured to rotate to vary a direction and magnitude of a magnetic field at different spin polarization regimes. |
| FILED | Friday, May 28, 2021 |
| APPL NO | 17/333474 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 17/28 (20130101) Original (OR) Class Measuring Electric Variables; Measuring Magnetic Variables G01R 33/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220221350 | Lynch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jerome P. Lynch (Ann Arbor, Michigan); Peng Sun (Ann Arbor, Michigan); Andrew Robert Burton (New York, New York) |
| ABSTRACT | A strain sensor includes a flexible substrate and a circuit disposed on the flexible substrate. The circuit includes an inductance to receive an excitation signal, the circuit being configured to generate a radio frequency response to the excitation signal via the inductance. The circuit includes an elongated trace coupled to the inductance and configured to bend and stretch longitudinally upon deformation of the flexible substrate. The elongated trace includes a non-uniformity configured such that the elongated trace deforms and tears at the non-uniformity and exhibits a non-linear increase in resistance as a tensile strain to which the elongated trace is subjected reaches a strain threshold. The non-linear increase in resistance modifies a characteristic of the radio frequency response of the circuit. |
| FILED | Friday, May 29, 2020 |
| APPL NO | 17/613415 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4504 (20130101) A61B 5/4851 (20130101) A61B 5/6878 (20130101) A61B 2562/164 (20130101) Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/106 (20130101) G01L 1/144 (20130101) Original (OR) Class Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/162 (20130101) H05K 1/165 (20130101) H05K 1/167 (20130101) H05K 2201/0154 (20130101) H05K 2201/10098 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220221795 | SIERKS et al. |
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| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| INVENTOR(S) | Michael SIERKS (Ft. McDowell, Arizona); Stephanie WILLIAMS (Phoenix, Arizona) |
| ABSTRACT | The present invention provides detection reagents and method for determining risk of traumatic brain injury (TBI), assessment of the amount of neuronal damage, and/or susceptibility to neurodegenerative disease in a subject. |
| FILED | Tuesday, October 12, 2021 |
| APPL NO | 17/499777 |
| CURRENT CPC | Peptides C07K 14/47 (20130101) C07K 2318/00 (20130101) C07K 2319/70 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) C12N 15/62 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/201 (20130101) G03F 7/2004 (20130101) Original (OR) Class G03F 7/2022 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220221799 | Eden et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Tristees of th University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | J. Gary Eden (Champaign, Illinois); Andrey Mironov (Urbana, Illinois); Dane J. Sievers (Fisher, Illinois) |
| ABSTRACT | A method for photoresist-free photolithography to pattern a surface of conductor or semiconductor substrate and deposit a material includes surface cleaning and irradiating a surface through a mask with VUV photons from a lamp. Photons are generated with a VUV lamp having a wavelength of 160 nm-200 nm and with an intensity sufficient to alter the surface. The photons are directed through a mask pattern to alter the surface chemistry or structure in those areas of the substrate defined by the mask. Material is selectively deposited onto the surface, in those portions of the surface that are exposed to the VUV photons, or unexposed to the VUV photons, depending on the substrate surface. A method uses a seed film and then electroplates metal onto the seed film in the mask pattern. A method provides for electroless deposition of metal and another for altering surface chemistry in the mask pattern. |
| FILED | Thursday, May 14, 2020 |
| APPL NO | 17/612830 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 18/1608 (20130101) Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 7/12 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/164 (20130101) G03F 7/70016 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/288 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220222075 | Pawlowski et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Robert S. Pawlowski (Beaverton, Oregon); Scott N. Cline (Portland, Oregon); Jason Howard (Portland, Oregon); Joshua B. Fryman (Corvallis, Oregon); Ivan B. Ganev (Portland, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert S. Pawlowski (Beaverton, Oregon); Scott N. Cline (Portland, Oregon); Jason Howard (Portland, Oregon); Joshua B. Fryman (Corvallis, Oregon); Ivan B. Ganev (Portland, Oregon) |
| ABSTRACT | In one embodiment, a processor includes decode circuitry and memory offload circuitry. The decode circuitry decodes an instruction to perform a direct memory access (DMA) operation, which includes an opcode and one or more fields. The opcode indicates a type of DMA operation to be performed. The one or more fields indicate a destination memory region and one or more data operands. The memory offload circuitry offloads the instruction from an execution pipeline and performs the DMA operation. |
| FILED | Saturday, April 02, 2022 |
| APPL NO | 17/712104 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/3001 (20130101) G06F 9/3004 (20130101) Original (OR) Class G06F 9/30145 (20130101) G06F 12/0238 (20130101) G06F 12/1081 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220222397 | Jain et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | Intel Corporation (Santa Clara, California) |
| INVENTOR(S) | Samkit Jain (Hillsboro, Oregon); Nicholas M. Pepperling (Portland, Oregon); Izajasz Piotr Wrosz (Banino, Poland); Joshua B. Fryman (Corvallis, Oregon); Ibrahim Hur (Portland, Oregon) |
| ABSTRACT | A distributed simulation system is provided that includes a plurality of computing nodes interconnected via a network implementing a Message Passing Interface (MPI) protocol. Each computing node is to simulate hardware logic of a core of a graph processing system and to simulate a respective system memory portion of the graph processing system. |
| FILED | Friday, April 01, 2022 |
| APPL NO | 17/711671 |
| CURRENT CPC | Electric Digital Data Processing G06F 1/03 (20130101) G06F 30/18 (20200101) G06F 30/20 (20200101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220222406 | Milton et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of South Carolina (Columbia, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew A. Milton (Lexington, South Carolina); Andrea Benigni (Vaals, Netherlands) |
| ABSTRACT | A method for generating a simulator of a target system includes parsing data defining operational components and component parameters, searching for and obtaining model code definitions within a library database, customizing the model code definitions based on the component parameters, constructing a system model, and generating solver code based the customized model code definitions of the target system. The solver code may be indicative of input and output operation of the target system. The method may also include concatenating the system model with the solver code to form a solver function definition for the target system, and converting the solver function definition into an field programmable gate array (FPGA) core or central processing unit (CPU) core for execution on a simulation device for the target system. |
| FILED | Friday, June 11, 2021 |
| APPL NO | 17/345482 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/331 (20200101) Original (OR) Class G06F 2111/20 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220222560 | MONROE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Maryland (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher MONROE (Ellicott City, Maryland); Martin LICHTMAN (Philadelphia, Pennsylvania); Ismail Volkan INLEK (Cary, North Carolina); Clayton CROCKER (Hyattsville, Maryland); Ksenia SOSNOVA (Silver Spring, Maryland) |
| ABSTRACT | The disclosure describes aspects of using multiple species in trapped-ion nodes for quantum networking. In an aspect, a quantum networking node is described that includes multiple memory qubits, each memory qubit being based on a 171Yb+ atomic ion, and one or more communication qubits, each communication qubit being based on a 138Ba+ atomic ion. The memory and communication qubits are part of a lattice in an atomic ion trap. In another aspect, a quantum computing system having a modular optical architecture is described that includes multiple quantum networking nodes, each quantum networking node including multiple memory qubits (e.g., based on a 171Yb+ atomic ion) and one or more communication qubits (e.g., based on a 138Ba+ atomic ion). The memory and communication qubits are part of a lattice in an atomic ion trap. The system further includes a photonic entangler coupled to each of the multiple quantum networking nodes. |
| FILED | Tuesday, March 29, 2022 |
| APPL NO | 17/707541 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) Electric Digital Data Processing G06F 9/3877 (20130101) G06F 9/5027 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Original (OR) Class Electric Discharge Tubes or Discharge Lamps H01J 49/422 (20130101) Transmission H04B 10/70 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0858 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220222567 | Reagor et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); Rigetti and Co, LLC (Berkeley, California) |
| ASSIGNEE(S) | Rigetti and Co, LLC (Berkeley, California) |
| INVENTOR(S) | Matthew J. Reagor (San Rafael, California); Jeffrey Cole Holzgrafe (Somerville, Massachusetts); Marko Loncar (Belmont, Massachusetts) |
| ABSTRACT | In a general aspect, a photonic quantum network is disclosed. In some implementations, microwave modes and optical modes are generated on first and second quantum processing units (QPUs) by operation of a first transducer device of the first QPU and a second transducer device of the second QPU. The microwave modes are transmitted within the first and second QPUs from the first and second transducer devices to respective first and second qubit devices. The optical modes are transmitted from the first and second QPUs to an interferometer device. By operation of the interferometer device, output signals are generated on respective output channels based on the optical modes from the first and second QPUs. Based on the output signals detected by operation of photodetector devices coupled to the respective output channels, quantum entanglement transferred to the first and second qubit devices by the microwave modes is identified. |
| FILED | Friday, March 04, 2022 |
| APPL NO | 17/686906 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/0203 (20130101) Computer Systems Based on Specific Computational Models G06N 10/40 (20220101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 39/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220222824 | Usumezbas et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SRI International (Menlo Park, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anil Usumezbas (North Brunswick, New Jersey); Bogdan Calin Mihai Matei (Princeton, New Jersey); Rakesh Kumar (West Windsor, New Jersey); Supun Samarasekera (Skillman, New Jersey) |
| ABSTRACT | A method, machine readable medium and system for semantic segmentation of 3D point cloud data includes determining ground data points of the 3D point cloud data, categorizing non-ground data points relative to a ground surface determined from the ground data points to determine legitimate non-ground data points, segmenting the determined legitimate non-ground and ground data points based on a set of common features, applying logical rules to a data structure of the features built on the segmented determined non-ground and ground data points based on their spatial relationships and incorporated within a machine learning system, and constructing a 3D semantics model from the application of the logical rules to the data structure. |
| FILED | Wednesday, September 15, 2021 |
| APPL NO | 17/476377 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 3/40 (20130101) G06T 7/10 (20170101) Original (OR) Class G06T 17/205 (20130101) G06T 2207/10028 (20130101) G06T 2207/20072 (20130101) G06T 2207/20081 (20130101) G06T 2207/20221 (20130101) G06T 2207/30181 (20130101) G06T 2210/56 (20130101) Image or Video Recognition or Understanding G06V 10/776 (20220101) G06V 20/70 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220223429 | Romanczyk et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Brian Romanczyk (Santa Barbara, California); Emmanuel Kayede (Santa Barbara, California); Wenjian Liu (Santa Barbara, California); Islam Sayed (Goleta, California); Umesh K. Mishra (Montecito, California) |
| ABSTRACT | N-polar transistor structures have relied on the use of dry etch processes that use plasmas generated from gaseous species to remove III-N layers as commercially viable wet etchants do not exist. The present disclosure reports on methods for the fabrication of N-polar III-N transistors using wet etches along with transistor structures that are enabled by the availability of wet-etches. |
| FILED | Friday, June 18, 2021 |
| APPL NO | 17/352139 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/308 (20130101) H01L 21/28581 (20130101) H01L 21/28587 (20130101) H01L 21/30612 (20130101) Original (OR) Class H01L 29/34 (20130101) H01L 29/205 (20130101) H01L 29/475 (20130101) H01L 29/872 (20130101) H01L 29/2003 (20130101) H01L 29/7786 (20130101) H01L 29/66212 (20130101) H01L 29/66462 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220223586 | Chowdhury et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Srabanti Chowdhury (San Ramon, California); Mohamadali Malakoutian (Davis, California); Matthew A. Laurent (Rancho Palos Verdes, California); Chenhao Ren (Davis, California); Siwei Li (Davis, California) |
| ABSTRACT | In certain examples, methods and semiconductor structures are directed to an integrated circuit (IC) having a diamond layer section and a GaN-based substrate being monolithically integrated or bonded as part of the same IC. In a specific example, the GaN-based substrate includes GaN, AlxGayN (0<x<1; x+y=1) and a dielectric layer, and a diamond layer section which may include polycrystalline diamond. The IC includes: a GaN-based field effect transistor (FET) integrated with a portion of the GaN-based substrate, and a diamond-based FET integrated with a portion of the diamond layer section, the diamond FET being electrically coupled to the GaN-based FET and situated over or against a surface region of the GaN-based substrate. |
| FILED | Friday, January 07, 2022 |
| APPL NO | 17/571128 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0262 (20130101) H01L 21/02389 (20130101) H01L 21/02527 (20130101) H01L 21/02595 (20130101) H01L 21/8258 (20130101) H01L 23/3732 (20130101) H01L 24/80 (20130101) H01L 27/085 (20130101) Original (OR) Class H01L 29/2003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220223808 | Mei et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, India) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jianguo Mei (West Lafayette, Indiana); Aristide Gumyusenge (Palo Alto, California) |
| ABSTRACT | A transistor device that includes a substrate comprising metallic gate contacts, a dielectric layer on the substrate comprising a polyimide or derivative thereof, a semiconductor layer on the dielectric layer comprising a semiconducting polymer confined in a host matrix material comprising a polyimide or derivative thereof, and source and drain contacts on the semiconductor layer. |
| FILED | Thursday, June 03, 2021 |
| APPL NO | 17/337707 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 73/1039 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/052 (20130101) Original (OR) Class H01L 51/0554 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220223907 | Yersak et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas A. Yersak (San Diego, California); Se-Hee Lee (Louisville, Colorado); Conrad Stoldt (Golden, Colorado) |
| ABSTRACT | An all-solid-state lithium battery, thermo-electromechanical activation of Li2S in sulfide based solid state electrolyte with transition metal sulfides, and electromechanical evolution of a bulk-type all-solid-state iron sulfur cathode, are disclosed. An example all-solid-state lithium battery includes a cathode having a transition metal sulfide mixed with elemental sulfur to increase electrical conductivity. In one example method of in-situ electromechanically synthesis of Pyrite (FeS2) from Sulfide (FeS) and elemental sulfur (S) precursors for operation of a solid-state lithium battery, FeS+S composite electrodes are cycled at moderately elevated temperatures. |
| FILED | Tuesday, February 15, 2022 |
| APPL NO | 17/672555 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/364 (20130101) H01M 4/382 (20130101) H01M 4/386 (20130101) H01M 4/5815 (20130101) H01M 10/052 (20130101) H01M 10/0525 (20130101) H01M 10/0562 (20130101) Original (OR) Class H01M 2300/0068 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220224259 | Davis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cepheid (Sunnyvale, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey Davis (Sunnyvale, California); Rajesh Nerkar (Sunnyvale, California); Richard J. Casler, JR. (Sunnyvale, California) |
| ABSTRACT | A DC electric motor having a stator mounted to a substrate, the stator having a coil assembly having a magnetic core, a rotor mounted to the stator with permanent magnets distributed radially about the rotor, the permanent magnets extending beyond the magnetic core, and sensors mounted to the substrate adjacent the permanent magnets. During operation of the motor passage of the permanent magnets over the sensors produces a substantially sinusoidal signal of varying voltage substantially without noise and/or saturation, allowing an angular position of the rotor to be determined from the sinusoidal signals by utilizing a transformation matrix or piece-wise algorithm applied in substantially linear portions of the sinusoidal signals without requiring use of additional hardware encoder or position sensors and without requiring noise-reduction or filtering of the signal. |
| FILED | Thursday, January 13, 2022 |
| APPL NO | 17/575100 |
| CURRENT CPC | Control or Regulation of Electric Motors, Electric Generators or Dynamo-electric Converters; Controlling Transformers, Reactors or Choke Coils H02P 6/16 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220224296 | Garay et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edgar Felipe Garay (Atlanta, Georgia); Hua Wang (Atlanta, Georgia) |
| ABSTRACT | A dual-drive power amplifier (PA) where the PA core includes a differential pair of transistors M1 and M2 that are driven by a coupling network having two transmission-line couplers, where a first transmission line section of a coupler is configured to transmit an input signal Vin through to drive a gate of the opposite transistor, while the second transmission line section is grounded at one end and coupled with the first transmission line section such that a coupled portion aVin of the input signal Vin drives the source terminal of a corresponding transistor. The arrangement of the coupling network allows the source terminals to be driven below ground potential. Embodiments disclosed here further provide an input matching network, a driver, an inter-stage matching network, and an output network for practical implementation of the PA core. |
| FILED | Thursday, March 03, 2022 |
| APPL NO | 17/685662 |
| CURRENT CPC | Amplifiers H03F 1/32 (20130101) H03F 1/0205 (20130101) H03F 1/565 (20130101) H03F 3/245 (20130101) Original (OR) Class H03F 2200/222 (20130101) H03F 2200/387 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220224605 | Jain et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | Intel Corporation (Santa Clara, California) |
| INVENTOR(S) | Samkit Jain (Hillsboro, Oregon); Izajasz Piotr Wrosz (Banino, Poland); Nicholas M. Pepperling (Portland, Oregon); Joshua B. Fryman (Corvallis, Oregon); Balasubramanian Seshasayee (Hillsboro, Oregon); Ibrahim Hur (Portland, Oregon) |
| ABSTRACT | A system simulator simulates operations of a plurality of interconnected devices in a simulation of a computing system. The system simulator implements a communication runtime in the simulation to receive a packet generated by a simulation of a first one of the plurality of devices to be sent to a simulation of a second one of the plurality of devices in the simulation. The communication runtime buffers the packet in its internal buffer and receives a query from the simulation of the second device based on buffer capacity in the simulation of the second device has capacity. The packet is sent from the communication runtime buffer to the simulation of the second device based on the query to simulate transmission of the packet from the first device to the second device on a link. |
| FILED | Friday, April 01, 2022 |
| APPL NO | 17/711502 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 41/145 (20130101) Original (OR) Class H04L 43/045 (20130101) H04L 43/062 (20130101) H04L 49/3063 (20130101) H04L 49/9047 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20220218513 | CARPICK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert W. CARPICK (Philadelphia, Pennsylvania); Shu YANG (Blue Bell, Pennsylvania); José A. BAUERMEISTER (Philadelphia, Pennsylvania); Megan B. ELINSKI (Philadelphia, Pennsylvania); Alexander I. BENNETT (Philadelphia, Pennsylvania); Haihuan WANG (Philadelphia, Pennsylvania); Wei-Liang CHEN (Newtown, Pennsylvania); Christian POHLMANN (Fairfax Station, Virginia); Willey Y LIN (Philadelphia, Pennsylvania) |
| ABSTRACT | The invention concerns personal wellness products comprising: a self-lubricating, tough hydrogel material, the hydrogel material optionally comprising a double interpenetrating network (D-IPN) matrix. |
| FILED | Thursday, May 14, 2020 |
| APPL NO | 17/610334 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 6/04 (20130101) Original (OR) Class Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 31/10 (20130101) A61L 31/16 (20130101) A61L 31/145 (20130101) Compositions of Macromolecular Compounds C08L 33/26 (20130101) C08L 51/04 (20130101) C08L 51/085 (20130101) C08L 2203/02 (20130101) C08L 2205/03 (20130101) C08L 2312/00 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 133/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220218752 | BAKER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington); FRED HUTCHINSON CANCER RESEARCH CENTER (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David BAKER (Seattle, Washington); Scott BOYKEN (Seattle, Washington); Marc Joseph LAJOIE (Seattle, Washington); Robert A. LANGAN (Seattle, Washington); Stanley R. RIDDELL (Seattle, Washington); Alexander SALTER (Seattle, Washington) |
| ABSTRACT | Disclosed are protein switches that can sequester bioactive peptides and/or binding domains, holding them in an inactive (“off”) state, until combined with a second designed polypeptide called the key, which induces a conformational change that activates (“on”) the bioactive peptide or binding domain only when the protein switch components are co/localized when bound to their targets, components of such protein switches, and their use. |
| FILED | Monday, May 18, 2020 |
| APPL NO | 17/610083 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 38/1774 (20130101) Peptides C07K 14/005 (20130101) C07K 14/4747 (20130101) C07K 14/7051 (20130101) C07K 14/70596 (20130101) C07K 2319/30 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 15/86 (20130101) C12N 15/625 (20130101) C12N 2501/2302 (20130101) C12N 2510/00 (20130101) C12N 2740/15043 (20130101) C12N 2800/107 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220218787 | Bucci et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vanni Bucci (Brookline, Massachusetts); Benedikt Mortzfeld (Cumberland, Rhode Island); Jacob Palmer (Oxford, United Kingdom) |
| ABSTRACT | This disclosure relates to genetically engineered microorganisms for treating or reducing the risk of bacterial infections or dysbiosis, and further discloses methods of making and using such microorganisms. |
| FILED | Friday, May 01, 2020 |
| APPL NO | 17/608053 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/741 (20130101) A61K 38/164 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 15/70 (20130101) C12N 15/635 (20130101) C12N 2510/00 (20130101) C12N 2800/101 (20130101) C12N 2830/002 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220218839 | BILGICER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Notre Dame du Lac (South Bend, Indiana) |
| ASSIGNEE(S) | University of Notre Dame du Lac (South Bend, Indiana) |
| INVENTOR(S) | Zihni Basar BILGICER (Granger, Indiana); Nathan J. ALVES (South Bend, Indiana) |
| ABSTRACT | A method of crosslinking a hetero-bifunctional photo crosslinking compound to an immunoglobulin having at least one heterocyclic photo reactive group and at least one non-photo reactive group where the non-photo reactive group is coupled to an effector molecule and the photo reactive group is coupled to the nucleotide binding site of an immunoglobulin. Alternatively, the photo crosslinker contains an orthogonal reactive group such as a thiol, which can be coupled to an effector molecule or functionalized ligand. |
| FILED | Thursday, September 02, 2021 |
| APPL NO | 17/465418 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/337 (20130101) A61K 47/6803 (20170801) A61K 47/6889 (20170801) Original (OR) Class Peptides C07K 16/00 (20130101) C07K 16/2887 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/531 (20130101) G01N 33/532 (20130101) G01N 33/533 (20130101) G01N 33/54353 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220219014 | Sampayan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California); Opcondys, Inc. (Manteca, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen E. Sampayan (Manteca, California); George James Caporaso (East Quogue, New York); Yu-Jiuan Chen (Fremont, California); Kristin Cortella Sampayan (Manteca, California) |
| ABSTRACT | Methods, devices and systems for ultra-high dose radiotherapy are disclosed. The described techniques rely in-part on active switching control of a photoconductive switch during the time the accelerator is accelerating charged particles to produce the output radiation at the desired dose rates. One radiotherapy system includes a particle accelerator configured to receive charged particles from a pulsed source. The particle accelerator includes a pipe configured to allow the charged particles to pass through as a beam, a magnetic core positioned proximate to the pipe and coupled to the pulsed source, and at least one multilayer insulator positioned adjacent to the pipe and the magnetic core. The system also includes a photoconductive switch coupled to the particle accelerator and configured to supply the particle accelerator with a plurality of voltage pulses. |
| FILED | Thursday, January 13, 2022 |
| APPL NO | 17/575074 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/1048 (20130101) Original (OR) Class A61N 5/1078 (20130101) A61N 2005/1088 (20130101) A61N 2005/1089 (20130101) Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 7/04 (20130101) H05H 7/06 (20130101) H05H 2277/11 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220219027 | Shuai et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Danmeng Shuai (Herndon, Virginia); Yen Shun (Herndon, Virginia); Braydon McCormick (Old Lyme, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Danmeng Shuai (Herndon, Virginia); Yen Shun (Herndon, Virginia); Braydon McCormick (Old Lyme, Connecticut) |
| ABSTRACT | The present disclosure relates to a multilayer fabric media comprising a non-woven membrane of fibers comprising at least one polymer in combination with at least one photoreactive agent mounted on a woven or non-woven substrate and coated with a light transmissible protective layer, to methods of forming such multilayer fabric media, and to articles of manufacture made therewith. |
| FILED | Friday, January 14, 2022 |
| APPL NO | 17/648013 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 9/16 (20130101) A61L 2101/02 (20200801) A61L 2209/14 (20130101) Devices, Apparatus or Methods for Life-saving A62B 23/025 (20130101) Original (OR) Class Air-conditioning; Air-humidification; Ventilation; Use of Air Currents for Screening F24F 8/24 (20210101) F24F 8/90 (20210101) F24F 8/108 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220219138 | John et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Administrators of the Tulane Educational Fund (New Orleans, Louisiana); UNIVERSITY OF CONNECTICUT (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vijay T. John (Destrehan, Louisiana); loulia A. Valla (Storrs, Connecticut) |
| ABSTRACT | Disclosed herein are compositions and methods that allow access to the interior of porous particles by inserting nanotubes into the particles. The compositions and methods disclosed herein are useful in several applications such as in catalytic reactions, plant active delivery, pharmaceutical drug delivery, and in absorbing environmental contaminants. |
| FILED | Friday, May 29, 2020 |
| APPL NO | 17/614955 |
| CURRENT CPC | Separation B01D 53/8671 (20130101) B01D 2255/50 (20130101) B01D 2257/504 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/183 (20130101) B01J 20/262 (20130101) Original (OR) Class B01J 20/3028 (20130101) B01J 20/3042 (20130101) B01J 20/3085 (20130101) B01J 20/28016 (20130101) B01J 21/12 (20130101) B01J 29/70 (20130101) B01J 35/0013 (20130101) B01J 35/026 (20130101) B01J 37/0018 (20130101) B01J 37/0072 (20130101) Mixtures of Fertilisers Covered Individually by Different Subclasses of Class C05; Mixtures of One or More Fertilisers With Materials Not Having a Specific Fertilising Activity, e.g Pesticides, Soil-conditioners, Wetting Agents; Fertilisers Characterised by Their Form C05G 5/27 (20200201) C05G 5/40 (20200201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220219150 | Li et al. |
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| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christina W. Li (Lafayette, Indiana); Alexander J. Shumski (Bethel Park, Pennsylvania); William A. Swann (West Lafayette, Indiana) |
| ABSTRACT | A heterogeneous catalyst for substrate-directed hydrogenation includes bimetallic nanoparticles of M1-M2, wherein M1 is a noble metal and M2 is a first-row transition metal. The bimetallic nanoparticles are on a substrate and atoms of both the noble metal and the first-row transition metal are distributed across surfaces of the bimetallic nanoparticles. The heterogeneous catalyst may be produced by providing M1-M2 bimetallic nanoparticles on a substrate to produce an intermediate composition, and performing a reduction process on the intermediate composition such that atoms of both the noble metal (M1) and the first-row transition metal (M2) are distributed across surfaces of the bimetallic nanoparticles and thereby form the heterogeneous catalyst. The catalyst may be used for performing directed hydrogenation of a substrate. |
| FILED | Tuesday, January 11, 2022 |
| APPL NO | 17/572909 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/08 (20130101) B01J 23/892 (20130101) B01J 23/8913 (20130101) B01J 23/8926 (20130101) Original (OR) Class B01J 35/006 (20130101) B01J 37/08 (20130101) B01J 37/0201 (20130101) Acyclic or Carbocyclic Compounds C07C 29/172 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220219168 | Bilsel |
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| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Osman Bilsel (Holden, Massachusetts) |
| ABSTRACT | The invention provides novel microfluidic devices and methods based on microscale gradients that are useful in a variety of applications, such as biomolecule stability, interactions, binding properties, etc. |
| FILED | Monday, June 08, 2020 |
| APPL NO | 17/607885 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) Original (OR) Class B01L 2200/026 (20130101) B01L 2200/0694 (20130101) B01L 2300/0819 (20130101) B01L 2400/0472 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220219197 | Lal et al. |
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| FUNDED BY |
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| APPLICANT(S) | Geegah LLC (Ithaca, New York) |
| ASSIGNEE(S) | Geegah LLC (Ithaca, New York) |
| INVENTOR(S) | Amit Lal (Ithaca, New York); Justin Kuo (Ithaca, New York) |
| ABSTRACT | A transceiver apparatus for maximizing voltage. A voltage booster or transformer is implemented using piezoelectric thin films in substrates, preferably CMOS substrates where active processing of RF signals can lead to highly integrated and inexpensive ICs. The voltage gain is achieved by cascading multiple transducers, formed in the same piezoelectric thin film, or films cascaded in series on top of each other. An array of transducers are connected in parallel or series, connected to the input or output port electrodes. Other approaches include placing the receive transformer in a location where the diffracting field from the transmitter transducer is incident on the receive transducer generating a higher ultrasonic field at the receive transformer and increasing the voltage is to connect an array of transducers, formed in the same layer, or different layers of piezoelectric layer in parallel in drive mode when the pulse is transmitted. |
| FILED | Monday, June 01, 2020 |
| APPL NO | 17/615310 |
| CURRENT CPC | Methods or Apparatus for Generating or Transmitting Mechanical Vibrations of Infrasonic, Sonic, or Ultrasonic Frequency, for Performing Mechanical Work in General B06B 1/0207 (20130101) Original (OR) Class B06B 1/0625 (20130101) B06B 2201/55 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220219239 | Elwany et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alaa Elwany (College Station, Texas); Ibrahim Karaman (College Station, Texas); Raymundo Arroyave (College Station, Texas); Raiyan Seede (College Station, Texas); Bing Zhang (College Station, Texas); Luke Johnson (College Station, Texas) |
| ABSTRACT | A method for determining alloy processing parameters is provided. Simulated melt pool temperature and melt pool geometries can be used to create an initial printability map based on laser speed and laser power, and the printability map can include regions with potential manufacturing defects. Single-track experiments can be used to calibrate the printability map, to produce a revised printability map. Finally, contour lines representing hatch spacing can also be added to the revised printability map to produce a final printability map that can be used to configure additive manufacturing machinery. |
| FILED | Wednesday, October 13, 2021 |
| APPL NO | 17/500004 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/80 (20210101) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 30/00 (20141201) B33Y 50/00 (20141201) Electric Digital Data Processing G06F 30/20 (20200101) G06F 2113/10 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220220055 | Tulaphol et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| ASSIGNEE(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| INVENTOR(S) | Sarttrawut Tulaphol (Nongyai Chonburi, Thailand); Noppadon Sathitsuksanoh (Louisville, Kentucky) |
| ABSTRACT | Provided are methods for producing levulinic acid from hemp hurds. In some embodiments, the methods include dissolving hemp hurds in an ionic liquid medium to produce a cellulose-rich product; hydrolyzing cellulose present in the cellulose-rich product to produce a glucose-rich product; dehydrating glucose present in the glucose-rich product, and/or fructose resulting from isomerization of the glucose, to produce 5-hydroxymethyl furfural (HMF); and hydrolyzing the HMF to levulinic acid. Also provided are methods for method for producing levulinic acid from sugar sources generally, which can include providing a sugar source, wherein the sugar source is a hydrolysis product produced by hydrolyzing a cellulose-rich product generated from hemp hurds and/or a cellulase digestion product of softwood pre-treated with phosphoric acid (H3PO4) or another acid; dehydrating the glucose present in the sugar source, and/or fructose resulting from isomerization of glucose present in the sugar source, to produce 5-hydroxymethyl furfural (HMF); and hydrolyzing the HMF to produce levulinic acid. |
| FILED | Thursday, April 16, 2020 |
| APPL NO | 17/604112 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 51/00 (20130101) Original (OR) Class Heterocyclic Compounds C07D 307/68 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 1/08 (20130101) C07H 3/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220220153 | CAI et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of South Florida (Tampa, Florida); H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE INC. (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jianfeng CAI (Tampa, Florida); Peng SANG (Tampa, Florida); Yan SHI (Tampa, Florida); Haitao JI (Tampa, Florida); Min ZHANG (Tampa, Florida) |
| ABSTRACT | Disclosed herein is a series of helical sulfono-γ-AApeptides that mimic the binding mode of the α-helical HD2 domain of B-Cell Lymphoma 9 (BCL9). As disclosed herein, sulfono-γ-AApeptides can structurally and functionally mimic the α-helical domain of BCL9, and selectively disrupt β-catenin/BCL9 PPIs with even higher potency. More intriguingly, these sulfono-γ-AApeptides can enter cancer cells, bind with β-catenin and disrupt β-catenin/BCL PPI, and exhibit excellent cellular activity, which is much more potent than the BCL9 peptide. Furthermore, enzymatic stability studies demonstrated the remarkable stability of the helical sulfono-γ-AApeptides, with no degradation in the presence of pronase for 24 h, augmenting their biological potential. |
| FILED | Friday, April 24, 2020 |
| APPL NO | 17/605219 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/08 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 7/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220220241 | Alexiou et al. |
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| FUNDED BY |
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| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ayse Asatekin Alexiou (Arlington, Massachusetts); Samuel John Lounder (Medford, Massachusetts) |
| ABSTRACT | Disclosed are linear/random/statistical copolymers comprising three types of monomeric units: hydrophobic monomeric units, zwitterionic monomeric units, and charged or ionizable monomeric units. Also provided are thin film composite membranes whose selective layer is comprised of the copolymers disclosed herein, and the methods of use thereof. |
| FILED | Friday, May 08, 2020 |
| APPL NO | 17/610230 |
| CURRENT CPC | Separation B01D 69/02 (20130101) B01D 71/32 (20130101) B01D 71/40 (20130101) B01D 2325/02 (20130101) B01D 2325/18 (20130101) B01D 2325/30 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 220/24 (20130101) Original (OR) Class Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/18 (20130101) C08J 2333/02 (20130101) C08J 2333/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220220514 | Lynch et al. |
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| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael David Lynch (Durham, North Carolina); Zhixia Ye (Raleigh, North Carolina) |
| ABSTRACT | The present disclosure provides compositions and methods for rapid production of chemicals in genetically engineered microorganisms in a large scale. Also provided herein is a high-throughput metabolic engineering platform enabling the rapid optimization of microbial production strains. The platform, which bridges a gap between current in vivo and in vitro bio-production approaches, relies on dynamic minimization of the active metabolic network. |
| FILED | Friday, January 14, 2022 |
| APPL NO | 17/576290 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/001 (20130101) C12N 9/0006 (20130101) C12N 9/0008 (20130101) C12N 9/0016 (20130101) C12N 9/0051 (20130101) C12N 9/1025 (20130101) C12N 15/746 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/42 (20130101) Original (OR) Class C12P 13/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220220536 | Halvorsen et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for the State University of New York (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenneth A. Halvorsen (Glenmont, New York); Lifeng Zhou (Albany, New York); Arun Richard Chandrasekaran (Albany, New York) |
| ABSTRACT | The present disclosure is directed to a nucleic acid, including: a DNA nanoswitch-nucleic acid complex including a deoxyribonucleic acid (DNA) nanoswitch and a ribonucleic acid binding site, wherein the DNA nanoswitch has a first conformation characterized as open, and a second conformation characterized as closed when in a presence of ribonucleic acid-of-interest. DNA nanoswitches that hybridize to preselected viral RNA are also disclosed, as well as methods of detecting or identifying an RNA virus, and kits related thereto. |
| FILED | Tuesday, January 11, 2022 |
| APPL NO | 17/573529 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6809 (20130101) Original (OR) Class C12Q 1/6837 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220221354 | Xiao et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jianliang Xiao (Louisville, Colorado); Wei Zhang (Boulder, Colorado); Chuanqian Shi (Boulder, Colorado) |
| ABSTRACT | The present disclosure provides a high-performance integrated strain sensing device that is highly stretchable, rehealable, recyclable and reconfigurable. This device can include dynamic covalent thermoset polyimine as the substrate and encapsulation, eutectic liquid metal alloy as the strain sensing unit and interconnects, and off-the-shelf chip components for measuring and magnifying functions. The device can be attached on the knee, elbow, wrist and finger joints for strain sensing and motion monitoring, and can also be attached on the abdomen to accurately measure respiration cycles. |
| FILED | Thursday, January 13, 2022 |
| APPL NO | 17/574880 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/6843 (20130101) Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/205 (20130101) G01L 1/2287 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220222256 | TU et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of South Florida (Tampa, Florida) |
| ASSIGNEE(S) | University of South Florida (Tampa, Florida) |
| INVENTOR(S) | Yicheng TU (Tampa, Florida); Mehrad ESLAMI (Tampa, Florida) |
| ABSTRACT | Disclosed are various embodiments for batched query processing and optimization in database management systems. A single algebraic expression is generated based at least in part on applying equivalence rules to algebraic expressions for a plurality of database queries of a database comprising a set of relations. The equivalence rules involve relational operators comprising Psi (ψ) operators. The database can be queried using a single database query to create a result that is equivalent to the plurality of database queries. |
| FILED | Friday, April 03, 2020 |
| APPL NO | 17/601048 |
| CURRENT CPC | Electric Digital Data Processing G06F 11/3409 (20130101) G06F 16/2282 (20190101) G06F 16/24539 (20190101) G06F 16/24544 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220222534 | DAI et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| INVENTOR(S) | Xiaoliang DAI (Princeton, New Jersey); Hongxu YIN (Princeton, New Jersey); Niraj K. JHA (Princeton, New Jersey) |
| ABSTRACT | According to various embodiments, a method for generating a compact and accurate neural network for a dataset that has initial data and is updated with new data is disclosed. The method includes performing a first training on the initial neural network architecture to create a first trained neural network architecture. The method additionally includes performing a second training on the first trained neural network architecture when the dataset is updated with new data to create a second trained neural network architecture. The second training includes growing one or more connections for the new data based on a gradient of each connection, growing one or more connections for the new data and the initial data based on a gradient of each connection, and iteratively pruning one or more connections based on a magnitude of each connection until a desired neural network architecture is achieved. |
| FILED | Friday, March 20, 2020 |
| APPL NO | 17/613284 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/082 (20130101) Original (OR) Class G06N 3/0445 (20130101) G06N 3/0481 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220222563 | LUCAS et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the Univ. of Colorado, a body corp. (Denver, Colorado); National Institute of Standards and Technology (Gaithersburg, Maryland); California Institute of Technology (Pasadena, California); University of Maryland, College Park (College Park, Maryland); Colorado School of Mines (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ANDREW LUCAS (Boulder, Colorado); Minh Tran (College Park, Maryland); Adam E. Ehrenberg (University Park, Maryland); Andrew Y. Guo (College Park, Maryland); Abhinav Deshpande (College Park, Maryland); Alexey Vyacheslavovich Gorshkov (Rockville, Maryland); Zhexuan Gong (Arvada, Colorado); Chi-Fang Chen (Pasadena, California); Yifan Hong (Boulder, Colorado) |
| ABSTRACT | A method for quantum state transfer includes iteratively expanding an initial quantum state from an initial qudit, of a plurality of qudits, over a sequence of expanding domains. For each iteration, a quantum circuit is applied to the qudits belonging to a respective domain of the sequence. The quantum circuit transforms the qudits of the respective domain into an intermediate quantum state that includes a W state formed with the qudits of the respective domain. The last iteration generates a maximally expanded state. The method may also include iteratively compressing the maximally expanded state according to a sequence of contacting domains. After compressing, a final qudit, of the plurality of qudits, is in a final quantum state that approximates the initial quantum state. |
| FILED | Wednesday, January 12, 2022 |
| APPL NO | 17/574301 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/20 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220223199 | Gu et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jie Gu (Evanston, Illinois); Zhengyu Chen (Evanston, Illinois) |
| ABSTRACT | Systems formed by a multi-bit three-transistor (3T) memory cell (i.e., dynamic-analog RAM) are provided. The 3T memory cell includes: a read-access transistor M1 in electrical communication with a read bitline; a switch transistor M2 in electrical communication with the read-access transistor M1 a write-access transistor M3 in electrical communication with the read-access transistor M1 and a write bitline; and a memory node MEM in electrical communication between the read-access transistor M1 and the write-access transistor M3, wherein the memory node MEM is configured to store a 4-bit weight WE. An array of the 3T memory cells (i.e., dynamic-analog RAMs) may form a computing-in-memory (CIM) macro, and further form a convolutional neural network (CNN) accelerator by communicating with an application-specific integrated circuit (ASIC) which communicates with a global weight static random access memory and an activation static random access memory. |
| FILED | Wednesday, January 12, 2022 |
| APPL NO | 17/574363 |
| CURRENT CPC | Electric Digital Data Processing G06F 7/5443 (20130101) Static Stores G11C 11/4085 (20130101) G11C 11/4094 (20130101) G11C 11/4096 (20130101) Original (OR) Class G11C 27/04 (20130101) Coding; Decoding; Code Conversion in General H03M 1/001 (20130101) H03M 1/462 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20220223312 — FORMATION AND MODIFICATIONS OF CERAMIC NANOWIRES AND THEIR USE IN FUNCTIONAL MATERIALS
| US 20220223312 | YUSHIN et al. |
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| FUNDED BY |
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| APPLICANT(S) | Sila Nanotechnologies Inc. (Alameda, California); GEORGIA TECH RESEARCH CORPORATION (ATLANTA, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gleb YUSHIN (Atlanta, Georgia); James BENSON (Atlanta, Georgia); Danni LEI (Atlanta, Georgia); Eugene BERDICHEVSKY (Alameda, California) |
| ABSTRACT | A catalyst-free synthesis method for the formation of a metalorganic compound comprising a desired (first) metal may include, for example, selecting another (second) metal and an organic solvent, with the second metal being selected to (i) be more reactive with respect to the organic solvent than the first metal and (ii) form, upon exposure of the second metal to the organic solvent, a reaction by-product that is more soluble in the organic solvent than the metalorganic compound. An alloy comprising the first metal and the second metal may be first produced (e.g., formed or otherwise obtained) and then treated with the organic solvent in a liquid phase or a vapor phase to form a mixture comprising (i) the reaction by-product comprising the second metal and (ii) the metalorganic compound comprising the first metal. The metalorganic compound may then be separated from the mixture in the form of a solid. |
| FILED | Monday, March 28, 2022 |
| APPL NO | 17/656844 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 13/18 (20130101) Compounds of the Metals Beryllium, Magnesium, Aluminium, Calcium, Strontium, Barium, Radium, Thorium, or of the Rare-earth Metals C01F 5/06 (20130101) C01F 7/30 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/72 (20130101) C01P 2004/03 (20130101) C01P 2004/16 (20130101) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/62227 (20130101) C04B 35/62231 (20130101) C04B 35/62236 (20130101) C04B 35/62263 (20130101) C04B 35/62844 (20130101) C04B 35/62884 (20130101) C04B 2235/441 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/06 (20130101) C07F 5/069 (20130101) Treatment of Inorganic Materials, Other Than Fibrous Fillers, to Enhance Their Pigmenting or Filling Properties; Preparation of Carbon Black; C09C 1/407 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 1/00 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/45525 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/023 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220223856 | Yang |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (Orlando, Florida) |
| ASSIGNEE(S) | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (Orlando, Florida) |
| INVENTOR(S) | Yang Yang (Orlando, Florida) |
| ABSTRACT | An alloy anode for a seawater based aqueous battery and a universal strategy for preparing anodes for use in seawater based aqueous batteries. Zn-M alloys (where M can be manganese or other transition metal) were prepared by co-electrodeposition in the presence of hydrogen bubble formation to produce a porous nanostructured alloy that can serve as an anode for a seawater based aqueous battery. Exemplary Zn—Mn alloy anodes achieved stability over thousands of cycles even under harsh electrochemical conditions, including testing in seawater-based aqueous electrolytes and using a high current density of 80 mA cm−2. The anode design strategy allows for the production of durable electrodes for aqueous batteries and other applications. |
| FILED | Monday, January 10, 2022 |
| APPL NO | 17/571976 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/42 (20130101) Original (OR) Class H01M 4/045 (20130101) H01M 10/36 (20130101) H01M 2004/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220223906 | Zhu et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhuoying Zhu (La Jolla, California); Shyue Ping Ong (La Jolla, California); Erik Wu (La Jolla, California); Nguyen Han (La Jolla, California); Ying Shirley Meng (La Jolla, California); IEK HENG CHU (La Jolla, California) |
| ABSTRACT | Presented are new, earth-abundant lithium superionic conductors, Li3Y(PS4)2 and Li5PS4Cl2, that emerged from a comprehensive screening of the Li—P—S and Li-M-P—S chemical spaces. Both candidates are derived from the relatively unexplored quaternary silver thiophosphates. One key enabler of this discovery is the development of a first-of-its-kind high-throughput first principles screening approach that can exclude candidates unlikely to satisfy the stringent Li+ conductivity requirements using a minimum of computational resources. Both candidates are predicted to be synthesizable, and are electronically insulating. Systems and methods according to present principles enable new, all-solid-state rechargeable lithium-ion batteries. |
| FILED | Wednesday, November 17, 2021 |
| APPL NO | 17/528280 |
| CURRENT CPC | Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 20/00 (20190201) G16C 20/30 (20190201) Information and Communication Technology [ICT] Specially Adapted for Specific Application Fields, Not Otherwise Provided for G16Z 99/00 (20190201) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/381 (20130101) H01M 4/382 (20130101) H01M 10/052 (20130101) H01M 10/054 (20130101) H01M 10/0562 (20130101) Original (OR) Class H01M 2300/0068 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220224244 | TAMASAS ELRAIS et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mohamed TAMASAS ELRAIS (Orlando, Florida); Issa BATARSEH (Orlando, Florida) |
| ABSTRACT | A multiport multilevel converter/inverter includes a connection point with a two-line connection. The multiport multilevel converter/inverter also includes a capacitor electrically coupled across the two-line connection of the connection point. The multiport multilevel converter/inverter also has a first flying capacitor multilevel path with a first external two connection port configured to connect outside of the multiport multilevel converter/inverter, and a first interface conveying DC power and that is electrically coupled to the connection point. The multiport multilevel converter/inverter also includes a second flying capacitor multilevel path with a second external two connection port configured to connect outside of the multiport multilevel converter/inverter, and a second interface conveying DC power and that is electrically coupled to the connection point. |
| FILED | Thursday, January 13, 2022 |
| APPL NO | 17/575201 |
| CURRENT CPC | Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 3/33569 (20130101) H02M 7/483 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220224583 | Rosenthal et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | James D. Rosenthal (Seattle, Washington); Matthew S. Reynolds (Seattle, Washington) |
| ABSTRACT | Examples of digital architectures for OFDM backscatter communication are described herein that use RF switches and discrete loads to implement digitally controlled single-sideband OFDM backscatter devices. One or more transforms may be implemented, including one or more IFFTs, LUTs, and/or numerically-controlled oscillators using one or more sine LUTs. |
| FILED | Friday, January 14, 2022 |
| APPL NO | 17/576707 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 5/0007 (20130101) H04L 27/02 (20130101) H04L 27/0008 (20130101) H04L 27/26265 (20210101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220225127 | Imran et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Regents of the University of Oklahoma (Norman, Oklahoma) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ali Imran (Bixby, Oklahoma); Hasan Farooq (Tulsa, Oklahoma); Ahmad Asghar (Seattle, Washington) |
| ABSTRACT | An apparatus comprises: a memory; and a processor coupled to the memory and configured to: build a prediction model that predicts next cells of UEs in a future time step of a mobile network; map the next cells to future user locations; determine future loads of BSs in the mobile network based on the future user locations; determine an optimization of the mobile network using the future loads; and implement the optimization by instructing the BSs to adjust a parameter in the future time step. |
| FILED | Thursday, June 11, 2020 |
| APPL NO | 17/617505 |
| CURRENT CPC | Transmission H04B 17/309 (20150115) Wireless Communication Networks H04W 24/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20220219014 | Sampayan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California); Opcondys, Inc. (Manteca, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen E. Sampayan (Manteca, California); George James Caporaso (East Quogue, New York); Yu-Jiuan Chen (Fremont, California); Kristin Cortella Sampayan (Manteca, California) |
| ABSTRACT | Methods, devices and systems for ultra-high dose radiotherapy are disclosed. The described techniques rely in-part on active switching control of a photoconductive switch during the time the accelerator is accelerating charged particles to produce the output radiation at the desired dose rates. One radiotherapy system includes a particle accelerator configured to receive charged particles from a pulsed source. The particle accelerator includes a pipe configured to allow the charged particles to pass through as a beam, a magnetic core positioned proximate to the pipe and coupled to the pulsed source, and at least one multilayer insulator positioned adjacent to the pipe and the magnetic core. The system also includes a photoconductive switch coupled to the particle accelerator and configured to supply the particle accelerator with a plurality of voltage pulses. |
| FILED | Thursday, January 13, 2022 |
| APPL NO | 17/575074 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/1048 (20130101) Original (OR) Class A61N 5/1078 (20130101) A61N 2005/1088 (20130101) A61N 2005/1089 (20130101) Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 7/04 (20130101) H05H 7/06 (20130101) H05H 2277/11 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220219790 | Siegel |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Atargis Energy Corporation (Pueblo, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stefan G. Siegel (Pueblo, Colorado) |
| ABSTRACT | A mooring latch includes a passive foundation portion and a latching portion. The latching portion includes a mechanism, a conical surface shaped to mate with a conical surface of the passive portion, a connector for connection to a mooring structure and permitting rotation about a horizontal axis. The mechanism has a latched configuration that mates the conical surfaces and permits rotations about a shared vertical axis of the conical surfaces. A mooring line threaded through the passive and latching portions and equipped with one or more stops may be used to guide the latching portion to or from the passive portion and to actuate latching or unlatching or the mooring latch. |
| FILED | Thursday, January 14, 2021 |
| APPL NO | 17/149272 |
| CURRENT CPC | Ships or Other Waterborne Vessels; Equipment for Shipping B63B 21/04 (20130101) Original (OR) Class B63B 2021/004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220219791 | Siegel |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Atargis Energy Corporation (Pueblo, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stefan G. Siegel (Pueblo, Colorado) |
| ABSTRACT | A mooring system for an Ocean Wave Energy Converters (OWEC) includes multiple structural members such as legs and braces that are linearly extendible and connected using mobile joints, each joint providing two degrees of freedom for rotations about the joint. Mobile joints also attach bottom ends of the legs to mooring points. A jacking system can change lengths of the extensible structural members to adjust depth of the OWEC for operation or for storm safety, to lift the OWEC out of the water for maintenance, or to align the OWEC to an incoming wave direction. |
| FILED | Thursday, January 14, 2021 |
| APPL NO | 17/149388 |
| CURRENT CPC | Ships or Other Waterborne Vessels; Equipment for Shipping B63B 21/50 (20130101) Original (OR) Class B63B 35/44 (20130101) B63B 2035/4466 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220219976 | Siriwardane et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States Department of Energy (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ranjani Siriwardane (Morgantown, West Virginia); Jarrett Riley (Morgantown, West Virginia) |
| ABSTRACT | The invention provides a process for producing hydrogen having the steps of reacting a fuel with a combination of two oxygen carriers to produce gaseous products and reduced oxygen carriers; reacting a portion of the reduced oxygen carriers with steam to generate hydrogen and partially oxidized oxygen carriers; and reacting the partially oxidized oxygen carriers and remaining reduced oxygen carriers with air to generate heat and regenerate the two oxygen carriers in their original oxidation state, wherein the heat and regenerated oxygen carriers are reused. |
| FILED | Wednesday, January 12, 2022 |
| APPL NO | 17/574347 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/78 (20130101) B01J 23/8892 (20130101) B01J 38/02 (20130101) Non-metallic Elements; Compounds Thereof; C01B 3/40 (20130101) C01B 3/382 (20130101) C01B 3/386 (20130101) Original (OR) Class C01B 2203/0233 (20130101) C01B 2203/0244 (20130101) C01B 2203/0261 (20130101) C01B 2203/0277 (20130101) C01B 2203/0811 (20130101) C01B 2203/1047 (20130101) C01B 2203/1076 (20130101) C01B 2203/1241 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220219992 | SHEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Research Triangle Institute (Research Triangle Park, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jian-Ping SHEN (Research Triangle Park, North Carolina); Brian TURK (Durham, North Carolina); Pradeepkumar SHARMA (Research Triangle Park, North Carolina); David DENTON (Mt. Pleasant, South Carolina) |
| ABSTRACT | A chromium-free catalyst for use in a fluidized bed reactor is described. The catalyst comprises 45-70 wt % Fe2O3, 5-15 wt % CuO, 20-35 wt % Al2O3, 10-20 wt % ZnO, and 1-15 wt % K2CO3. The catalyst has a Davison Index (DI %) of less than or equal to 15. A method for converting carbon monoxide (CO) into carbon-dioxide (CO2) using the catalyst is described. The method includes introducing H2O and CO into a fluidized bed reactor having an operating temperature between about 375° C. and about 450° C. and comprising the chromium free catalyst. The CO conversion is at least 60%. |
| FILED | Wednesday, April 22, 2020 |
| APPL NO | 17/609806 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 8/24 (20130101) B01J 19/0093 (20130101) B01J 23/80 (20130101) B01J 35/0026 (20130101) B01J 35/1014 (20130101) Non-metallic Elements; Compounds Thereof; C01B 3/16 (20130101) C01B 32/50 (20170801) Original (OR) Class C01B 2203/0283 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220220586 | Ellison et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul A. Ellison (Madison, Wisconsin); Robert Jerome Nickles (Madison, Wisconsin); Todd E. Barnhart (Madison, Wisconsin); Jonathan W. Engle (Middleton, Wisconsin); Christopher J. Kutyreff (Madison, Wisconsin) |
| ABSTRACT | Cobalt intermetallic compounds that include cobalt and a second element are provided. The isotopes of the second element in the compounds are present in their natural isotopic abundance or in an enriched isotopic abundance. Methods of making the compounds and methods of using the compounds as targets in the production of radionuclides are further provided. |
| FILED | Monday, May 18, 2020 |
| APPL NO | 17/610575 |
| CURRENT CPC | Alloys C22C 19/07 (20130101) Original (OR) Class Conversion of Chemical Elements; Radioactive Sources G21G 1/10 (20130101) G21G 4/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220220858 | Hafner et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Troy Hafner (Honea Path, South Carolina); Brad Wilson VanTassel (Easley, South Carolina); Christopher Donald Porter (Greenville, South Carolina); Srikanth Chandrudu Kottilingam (Greenville, South Carolina) |
| ABSTRACT | An embodiment of an independent cooling circuit for selectively delivering cooling fluid to a component of a gas turbine system includes: a plurality of independent circuits of cooling channels embedded within an exterior wall of the component, wherein the plurality of circuits of cooling channels are interwoven together; an impingement plate; and a plurality of feed tubes connecting the impingement plate to the exterior wall of the component and fluidly coupling each of the plurality of circuits of cooling channels to at least one supply of cooling fluid, wherein, in each of the plurality of circuits of cooling channels, the cooling fluid flows through the plurality of feed tubes into the circuit of cooling channels only in response to a formation of a breach in the exterior wall of the component that exposes at least one of the cooling channels of the circuit of cooling channels. |
| FILED | Friday, October 25, 2019 |
| APPL NO | 16/663912 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/187 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220221670 | PATRA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Susant K. PATRA (Brentwood, California); Razi-Ul Muhammad HAQUE (San Francisco, California); Komal KAMPASI (San Francisco, California); Ian Seth LADNER (Livermore, California) |
| ABSTRACT | The present disclosure relates to a monolithic waveguide substrate for enabling routing of at least one optical signal. The monolithic waveguide substrate has a monolithic engineered substrate having a uniform material composition throughout, with a first index of refraction, and with a plurality of three-dimensional waveguides each being formed fully within an interior volume thereof by a corresponding plurality of three-dimensional waveguide channels. The three-dimensional waveguide channels are formed by wall portions each having a second index of refraction different from the first index of refraction. |
| FILED | Friday, January 28, 2022 |
| APPL NO | 17/587591 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/421 (20130101) G02B 6/4278 (20130101) G02B 6/4291 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220222563 | LUCAS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the Univ. of Colorado, a body corp. (Denver, Colorado); National Institute of Standards and Technology (Gaithersburg, Maryland); California Institute of Technology (Pasadena, California); University of Maryland, College Park (College Park, Maryland); Colorado School of Mines (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ANDREW LUCAS (Boulder, Colorado); Minh Tran (College Park, Maryland); Adam E. Ehrenberg (University Park, Maryland); Andrew Y. Guo (College Park, Maryland); Abhinav Deshpande (College Park, Maryland); Alexey Vyacheslavovich Gorshkov (Rockville, Maryland); Zhexuan Gong (Arvada, Colorado); Chi-Fang Chen (Pasadena, California); Yifan Hong (Boulder, Colorado) |
| ABSTRACT | A method for quantum state transfer includes iteratively expanding an initial quantum state from an initial qudit, of a plurality of qudits, over a sequence of expanding domains. For each iteration, a quantum circuit is applied to the qudits belonging to a respective domain of the sequence. The quantum circuit transforms the qudits of the respective domain into an intermediate quantum state that includes a W state formed with the qudits of the respective domain. The last iteration generates a maximally expanded state. The method may also include iteratively compressing the maximally expanded state according to a sequence of contacting domains. After compressing, a final qudit, of the plurality of qudits, is in a final quantum state that approximates the initial quantum state. |
| FILED | Wednesday, January 12, 2022 |
| APPL NO | 17/574301 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/20 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220223130 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Evelyn N. Wang (Cambridge, Massachusetts); Gang Chen (Carlisle, Massachusetts); Xuanhe Zhao (Allston, Massachusetts); Elise M. Strobach (Clear Lake, Wisconsin); Bikramjit S. Bhatia (Cambridge, Massachusetts); Lin Zhao (Revere, Massachusetts); Sungwoo Yang (Chattanooga, Tennessee); Lee A. Weinstein (Somerville, Massachusetts); Thomas A. Cooper (Boston, Massachusetts); Shaoting Lin (Cambridge, Massachusetts) |
| ABSTRACT | Described herein are window retrofits including a monolithic silica aerogel slab having (i) an average haze value of <5% as calculated in accordance with ASTM standard D1003-13 and (ii) a U-factor of <0.5 BTU/sf/hr/° F., and a transparent polymer envelope sealed at an internal pressure of ≤1 atmosphere, wherein the monolithic silica aerogel slab is encapsulated in the transparent polymer envelope. The monolithic aerogel slab can have a transmittance >94% at 8 mm thickness. The window retrofit can be bonded to a glass sheet. |
| FILED | Thursday, October 21, 2021 |
| APPL NO | 17/507491 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 7/12 (20130101) B32B 7/027 (20190101) B32B 9/045 (20130101) B32B 2255/10 (20130101) B32B 2255/20 (20130101) B32B 2305/026 (20130101) B32B 2307/54 (20130101) B32B 2307/72 (20130101) B32B 2307/102 (20130101) B32B 2307/304 (20130101) B32B 2307/412 (20130101) B32B 2307/546 (20130101) Fixed or Movable Closures for Openings in Buildings, Vehicles, Fences or Like Enclosures in General, e.g Doors, Windows, Blinds, Gates E06B 9/24 (20130101) E06B 2009/2417 (20130101) Sound-producing Devices; Methods or Devices for Protecting Against, or for Damping, Noise or Other Acoustic Waves in General; Acoustics Not Otherwise Provided for G10K 11/168 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220223311 | Kozioziemski |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bernard J. Kozioziemski (Livermore, California) |
| ABSTRACT | Devices, systems and methods for performing X-ray scans with a single line of sight using a lens array for capturing the light field of the X-rays are described. In one example aspect, an X-ray optical system includes a primary optics subsection positioned to receive incoming X-rays after traversal through an object and to redirect the received incoming X-rays onto an intermediate image plane. The system also includes a microlens array positioned at or close to the intermediate image plane to receive at least some of the received incoming X-rays after redirection by the primary optics subsection to diffract the X-rays that are incident thereupon. |
| FILED | Thursday, May 23, 2019 |
| APPL NO | 17/613477 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/04 (20130101) Techniques for Handling Particles or Ionising Radiation Not Otherwise Provided For; Irradiation Devices; Gamma Ray or X-ray Microscopes G21K 1/062 (20130101) G21K 1/065 (20130101) Original (OR) Class G21K 7/00 (20130101) G21K 2201/067 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220223778 | Kutsaev et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RadiaBeam Technologies, LLC (Santa Monica, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sergey Kutsaev (Santa Monica, California); Ronald Agustsson (Venice, California); Kirill Taletski (Santa Monica, California) |
| ABSTRACT | Embodiments disclosed herein include a resonator for use in quantum computing. The resonator can include a housing that is disposed along a resonator axis. The housing can have a first portion extending from a housing distal end to near a qubit location and a second portion extending from near the qubit location to a housing proximal end. The housing can define a cavity extending from a cavity proximal end to a cavity distal end along a portion of the resonator axis. The housing can include a protrusion extending axially from the housing distal end along the resonator axis to near the qubit location. A proximal portion of the protrusion can include a tapered portion. The resonator can include a qubit extending into the cavity at the qubit location. |
| FILED | Wednesday, April 22, 2020 |
| APPL NO | 17/605915 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/40 (20220101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 39/025 (20130101) Original (OR) Class H01L 39/223 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220223797 | BAZAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Guillermo C. BAZAN (Goleta, California); Thomas S. VAN DER POLL (Goleta, California); Thuc-Quyen NGUYEN (Santa Barbara, California); John LOVE (Goleta, California) |
| ABSTRACT | Small organic molecule chromophores containing a benzo[c][1,2,5]thiadiazole with an electron-withdrawing substituent W in the 5-position (5BTH), benzo[c][1,2,5]oxadiazole with an electron-withdrawing substituent W in the 5-position (5BO), 2H-benzo[d][1,2,3]triazole (5BTR) with an electron-withdrawing substituent W in the 5-position (5BTR), 5-fluorobenzo[c][1,2,5]thiadiazole (FBTH), 5-fluorobenzo[c][1,2,5]oxadiazole (FBO), or 5-fluoro-2H-benzo[d][1,2,3]triazole (FBTR) core structure are disclosed. Such compounds can be used in organic heterojunction devices, such as organic small molecule solar cells and transistors. |
| FILED | Wednesday, August 25, 2021 |
| APPL NO | 17/412135 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) Heterocyclic Compounds C07D 495/04 (20130101) C07D 519/00 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/0816 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/42 (20130101) H01L 51/0047 (20130101) H01L 51/0068 (20130101) H01L 51/0071 (20130101) Original (OR) Class H01L 51/0094 (20130101) H01L 51/4253 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/549 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 70/50 (20151101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220223846 | Whittingham et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for The State University of New York (Binghamton, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | M. Stanley Whittingham (Vestal, New York); Jia Ding (Binghamton, New York) |
| ABSTRACT | An electrode comprising a space group Pna21 VOPO4 lattice, capable of electrochemical insertion and release of alkali metal ions, e.g., sodium ions. The VOPO4 lattice may be formed by solid phase synthesis of KVOPO4, milled with carbon particles to increase conductivity. A method of forming an electrode is provided, comprising milling a mixture of ammonium metavanadate, ammonium phosphate monobasic, and potassium carbonate; heating the milled mixture to a reaction temperature, and holding the reaction temperature until a solid phase synthesis of KVOPO4 occurs; milling the KVOPO4 together with conductive particles to form a conductive mixture of fine particles; and adding binder material to form a conductive cathode. A sodium ion battery is provided having a conductive NaVOPO4 cathode derived by replacement of potassium in KVOPO4, a sodium ion donor anode, and a sodium ion transport electrolyte. The VOPO4, preferably has a volume greater than 90 Å3 per VOPO4. |
| FILED | Monday, March 28, 2022 |
| APPL NO | 17/705780 |
| CURRENT CPC | Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 31/006 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 14/18 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/04 (20130101) C08K 3/32 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 127/16 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/381 (20130101) Original (OR) Class H01M 4/622 (20130101) H01M 4/623 (20130101) H01M 4/625 (20130101) H01M 4/5825 (20130101) H01M 10/054 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220223874 | NAZAR et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Waterloo (Waterloo, Canada) |
| ASSIGNEE(S) | University of Waterloo (Waterloo, Canada) |
| INVENTOR(S) | Linda Faye NAZAR (Waterloo, Canada); Chun Yuen KWOK (Scarborough, Canada); Mario GAUTHIER (Waterloo, Canada) |
| ABSTRACT | Disclosed is an electrochemical cell comprising a lithium-based anode and a sulfur-based cathode and an electrolyte, wherein the cathode material comprises a polymeric binder, wherein the binder comprises ammonium functional groups. In one aspect, the polymeric binder comprises ammonium chloride functional groups. |
| FILED | Monday, May 25, 2020 |
| APPL NO | 17/595720 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/622 (20130101) Original (OR) Class H01M 4/625 (20130101) H01M 4/5815 (20130101) H01M 10/0525 (20130101) H01M 2004/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220223880 | PAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ke-Ji PAN (Ellicott City, Maryland); Mohammed Hussain ABDUL JABBAR (College Park, Maryland); Dong DING (Idaho Falls, Idaho); Eric WACHSMAN (Fulton, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ke-Ji PAN (Ellicott City, Maryland); Mohammed Hussain ABDUL JABBAR (College Park, Maryland); Dong DING (Idaho Falls, Idaho); Eric WACHSMAN (Fulton, Maryland) |
| ABSTRACT | In various embodiments, a solid oxide fuel cell features a functional layer for reducing interfacial resistance between the cathode and the solid electrolyte. |
| FILED | Tuesday, November 02, 2021 |
| APPL NO | 17/516851 |
| CURRENT CPC | Processes for Applying Fluent Materials to Surfaces, in General B05D 7/50 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/8663 (20130101) Original (OR) Class H01M 4/9033 (20130101) H01M 4/9066 (20130101) H01M 8/126 (20130101) H01M 8/1213 (20130101) H01M 8/1246 (20130101) H01M 8/1253 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220223906 | Zhu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhuoying Zhu (La Jolla, California); Shyue Ping Ong (La Jolla, California); Erik Wu (La Jolla, California); Nguyen Han (La Jolla, California); Ying Shirley Meng (La Jolla, California); IEK HENG CHU (La Jolla, California) |
| ABSTRACT | Presented are new, earth-abundant lithium superionic conductors, Li3Y(PS4)2 and Li5PS4Cl2, that emerged from a comprehensive screening of the Li—P—S and Li-M-P—S chemical spaces. Both candidates are derived from the relatively unexplored quaternary silver thiophosphates. One key enabler of this discovery is the development of a first-of-its-kind high-throughput first principles screening approach that can exclude candidates unlikely to satisfy the stringent Li+ conductivity requirements using a minimum of computational resources. Both candidates are predicted to be synthesizable, and are electronically insulating. Systems and methods according to present principles enable new, all-solid-state rechargeable lithium-ion batteries. |
| FILED | Wednesday, November 17, 2021 |
| APPL NO | 17/528280 |
| CURRENT CPC | Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 20/00 (20190201) G16C 20/30 (20190201) Information and Communication Technology [ICT] Specially Adapted for Specific Application Fields, Not Otherwise Provided for G16Z 99/00 (20190201) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/381 (20130101) H01M 4/382 (20130101) H01M 10/052 (20130101) H01M 10/054 (20130101) H01M 10/0562 (20130101) Original (OR) Class H01M 2300/0068 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220223932 | McNally et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joshua S. McNally (Idaho Falls, Idaho); Luis A. Diaz Aldana (Idaho Falls, Idaho); John R. Klaehn (Idaho Falls, Idaho); Tedd E. Lister (Bangor, Maine); David W, Reed (Idaho Falls, Idaho) |
| ABSTRACT | A method of recovering active materials from a rechargeable battery comprises placing an active material of a rechargeable battery in a cathode chamber comprising a cathode of an electrochemical cell comprising the cathode chamber, an anode chamber comprising an anode, and a membrane separating the cathode chamber from the anode chamber, contacting the active material in the cathode chamber with an electrolyte comprising an acid, ferric ions, and ferrous ions, and dissolving at least one of lithium and cobalt from the active material into the electrolyte. Related apparatuses for recovering metals from active materials of rechargeable batteries are also disclosed. |
| FILED | Thursday, May 28, 2020 |
| APPL NO | 17/595967 |
| CURRENT CPC | Production and Refining of Metals; Pretreatment of Raw Materials C22B 7/007 (20130101) C22B 23/0415 (20130101) C22B 26/12 (20130101) C22B 26/22 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 10/44 (20130101) H01M 10/54 (20130101) Original (OR) Class H01M 10/0525 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220224261 | Haupt |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Brookhaven Science Associates, LLC (Upton, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elaine Justine Haupt (Mattituck, New York) |
| ABSTRACT | A method and device for determining the position of a rotor in a brushless motor is provided. The method generally includes: injecting electrical signals into a stator of the brushless motor; measuring scattering parameters reflected back from the stator, wherein the scattering parameters are influenced by the near-field dynamics impaired by the motor; and comparing the measured scattering parameters to a predetermined data set of scattering parameters for known rotor positions to determine the position of the rotor. The method and device is also suitable for determining a condition of a motor or a generator. |
| FILED | Wednesday, April 29, 2020 |
| APPL NO | 17/607243 |
| CURRENT CPC | Control or Regulation of Electric Motors, Electric Generators or Dynamo-electric Converters; Controlling Transformers, Reactors or Choke Coils H02P 6/183 (20130101) Original (OR) Class H02P 2203/11 (20130101) H02P 2207/05 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220224639 | Froese et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hewlett Packard Enterprise Development LP (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edwin L. Froese (Burnaby British Columbia, California); Robert L. Alverson (Seattle, Washington); Konstantinos Fragkiadakis (Bristol Avon, United Kingdom) |
| ABSTRACT | Systems and methods are provided for managing multicast data transmission in a network having a plurality of switches arranged in a Dragonfly network topology, including: receiving a multicast transmission at an edge port of a switch and identifying the transmission as a network multicast transmission; creating an entry in a multicast table within the switch; routing the multicast transmission across the network to a plurality of destinations via a plurality of links, wherein at each of the links the multicast table is referenced to determine to which ports the multicast transmission should be forwarded; and changing, when necessary, the virtual channel used by each copy of the multicast transmission as the copy progresses through the network. |
| FILED | Monday, March 23, 2020 |
| APPL NO | 17/594686 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 45/16 (20130101) H04L 45/021 (20130101) H04L 45/42 (20130101) Original (OR) Class H04L 45/566 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220225546 | MORENO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado); BorgWarner, Inc. (Auburn Hills, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gilberto MORENO (Thornton, Colorado); Sreekant Venkat Jagannath NARUMANCHI (Golden, Colorado); Xuhui FENG (Golden, Colorado); Ammar OSMAN (Golden, Colorado); Steve Michael MYERS (Oxford, Michigan); Brian James Kelly (Lakewood, Colorado); Paul Philip Paret (Denver, Colorado) |
| ABSTRACT | The present disclosure relates generally to methods and devices for the cooling (or removal of heat from) power electronics modules in automotive vehicles, wherein the cooling is done by positioning the power electronics module in a housing, directing a fluid into the housing, and impinging the fluid onto the power electronics module and/or an electrical connection in contact with the power electronics module. |
| FILED | Tuesday, January 11, 2022 |
| APPL NO | 17/573445 |
| CURRENT CPC | Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 7/209 (20130101) H05K 7/20272 (20130101) H05K 7/20927 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20220218682 | Habib |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amyn Habib (Dallas, Texas) |
| ABSTRACT | Provided herein are pharmaceutical compositions comprising an effective amount of an agent that inhibits EGFR signaling and izoniazid, which are useful for treating cancer. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| FILED | Friday, May 08, 2020 |
| APPL NO | 17/609757 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/517 (20130101) A61K 31/4409 (20130101) Original (OR) Class A61K 31/5377 (20130101) A61K 39/3955 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220218701 | Clines |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government As Represented By The Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregory A. Clines (Ann Arbor, Michigan) |
| ABSTRACT | Disclosed are compositions comprising an endothelin A receptor (ETAR) antagonist, an anti-androgen therapy, and chemical castration therapy. Also disclosed are compositions comprising an ETAR antagonist, copackaged or coformulated with an anti-androgen therapy. Disclosed are methods of preventing prostate cancer metastasis comprising administering to a subject having prostate cancer an ETAR antagonist, an anti-androgen therapy, and castration therapy. Also disclosed are methods of increasing survival in a prostate cancer patient, comprising administering to the patient having prostate cancer an ETAR antagonist, an anti-androgen therapy, and castration therapy. |
| FILED | Friday, May 29, 2020 |
| APPL NO | 17/614956 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/58 (20130101) A61K 31/415 (20130101) A61K 31/497 (20130101) Original (OR) Class A61K 31/4025 (20130101) A61K 31/4166 (20130101) A61K 31/4439 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 13/08 (20180101) A61P 35/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220218712 | Salvemini et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Saint Louis University (St. Louis, Missouri); U.S. Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniela Salvemini (Chesterfield, Missouri); Susan A. Farr (St. Louis, Missouri) |
| ABSTRACT | Disclosed herein are methods and compositions for the treatment of Alzheimer's disease by administering to a subject in need thereof a selective agonist for the human adenosine A3 receptor (A3AR) subtype. Also disclosed are methods and compositions for prophylactically treating Alzheimer's disease by administering to a subject in need thereof a selective agonist for the human adenosine A3 receptor (A3AR) subtype. |
| FILED | Tuesday, February 25, 2020 |
| APPL NO | 17/433808 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/52 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20220221616 | ARDANUY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | INNOVIM, LLC (Greenbelt, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Philip ARDANUY (Greenbelt, Maryland); Sibren ISAACMAN (Greenbelt, Maryland); Justin HICKS (Greenbelt, Maryland); Ethan CARTON (Greenbelt, Maryland) |
| ABSTRACT | The invention describes a new and improved weather forecasting model which utilizes neural networks to execute equations which use timed inputs from current weather forecasting models to produce more accurate weather predictions. By innovatively combining several independent techniques through Machine Learning (ML), the LEARN2 decision support tool can improve heavy precipitation forecast skill in Week 1 and extend the duration of skillful forecasts two additional days into Week 2, as measured by accuracy and precision against verification observations—beyond that presently available from today's operational GFS and GEFS predictions alone. The LEARN2 predictions, while based upon the precipitation and atmospheric field forecasts of the GFS or GEFS, add in three significant additional information sources: (1) remotely sensed satellite observations untainted by the data assimilation analyses conducted by NWP centers as a part of each forecast's initialization. While allowing the models to better assimilate the observations, there is an unavoidable loss of in-formation—information that these observed fields still retain; (2) sub-seasonal-to-seasonal (S2S) teleconnection indices, which pro-vide information on global circulation patterns that modulate synoptic meteorology; and (3) assessments of NWP model forecast biases, obtained from a sequence of forecasts and their verifications. Operational NWP models have inherent biases that must be removed either objectively or subjectively before use. |
| FILED | Monday, January 10, 2022 |
| APPL NO | 17/572534 |
| CURRENT CPC | Meteorology G01W 1/00 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/0454 (20130101) G06N 3/0481 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220222563 | LUCAS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the Univ. of Colorado, a body corp. (Denver, Colorado); National Institute of Standards and Technology (Gaithersburg, Maryland); California Institute of Technology (Pasadena, California); University of Maryland, College Park (College Park, Maryland); Colorado School of Mines (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ANDREW LUCAS (Boulder, Colorado); Minh Tran (College Park, Maryland); Adam E. Ehrenberg (University Park, Maryland); Andrew Y. Guo (College Park, Maryland); Abhinav Deshpande (College Park, Maryland); Alexey Vyacheslavovich Gorshkov (Rockville, Maryland); Zhexuan Gong (Arvada, Colorado); Chi-Fang Chen (Pasadena, California); Yifan Hong (Boulder, Colorado) |
| ABSTRACT | A method for quantum state transfer includes iteratively expanding an initial quantum state from an initial qudit, of a plurality of qudits, over a sequence of expanding domains. For each iteration, a quantum circuit is applied to the qudits belonging to a respective domain of the sequence. The quantum circuit transforms the qudits of the respective domain into an intermediate quantum state that includes a W state formed with the qudits of the respective domain. The last iteration generates a maximally expanded state. The method may also include iteratively compressing the maximally expanded state according to a sequence of contacting domains. After compressing, a final qudit, of the plurality of qudits, is in a final quantum state that approximates the initial quantum state. |
| FILED | Wednesday, January 12, 2022 |
| APPL NO | 17/574301 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/20 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20220219130 | Townsend et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sidus Space, Inc. (Merritt Island, Florida) |
| ASSIGNEE(S) | Sidus Space, Inc. (Merritt Island, Florida) |
| INVENTOR(S) | Ivan Townsend (Kennedy Space Center, Florida); Jason Schuler (Kennedy Space Center, Florida); Robert Cox (Kennedy Space Center, Florida) |
| ABSTRACT | A vacuum chamber may include an ambient side and a vacuum side. The vacuum chamber may be configured to carry a feedthrough that may include a hollow tube, a first O-ring captured by a first recess within the hollow tube and a rod extending through the hollow tube. The outer circumference of the rod may be configured to contact an entirety of an inner circumference of the first O-ring. A vacuum fitting having an inner circumference may be fixedly secured to the hollow tube. The rod may be operable to be linearly movable within the hollow tube and may be rotatably movable about an axis within the hollow tube. An object may be secured to the rod and may be linearly and rotatably moved within the vacuum chamber. |
| FILED | Friday, April 01, 2022 |
| APPL NO | 17/657677 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 3/006 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220221360 | Burns et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINSTRATOR OF NASA (WASHINGTON, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Devin E. Burns (Yorktown, Virginia); Peter A. Parker (Yorktown, Virginia) |
| ABSTRACT | The present disclosure describes internal force transducer balance system and related methods. One such system includes an internal balance having a cylindrical body extending axially along a longitudinal direction that includes an axial strain measurement component of the internal balance, wherein the axial strain measurement component is configured to measure an axial force applied to the internal balance. Disclosed he systems further includes an integral fluid flow path that continuously extends from the first end to the second end of the balance, wherein the integral fluid flow path is positioned in an interior core of the balance and is routed through the axial strain measurement component of the internal balance. The integral fluid flow path also comprises one or more turns as the integral fluid flow path is routed through the axial strain measurement component of the internal balance. |
| FILED | Monday, August 30, 2021 |
| APPL NO | 17/461107 |
| CURRENT CPC | Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/26 (20130101) G01L 9/006 (20130101) G01L 19/0023 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20220220551 | Philibert |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Behavioral Diagnostics, LLC (Coralville, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Philibert (Iowa City, Iowa) |
| ABSTRACT | This disclosure relates to differentially methylated regions (DMRs) and an equation that can be applied when using epigenetic analysis in a biological sample that includes more than one cell type and, therefore, more than one methylation set point (e.g., saliva). This disclosure relates to differentially methylated regions (DMRs) and an equation that can be applied when using epigenetic analysis in a biological sample that includes more than one cell type and, therefore, more than one methylation set point (e.g., saliva). |
| FILED | Wednesday, April 22, 2020 |
| APPL NO | 17/605019 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6858 (20130101) Original (OR) Class C12Q 1/6881 (20130101) C12Q 2600/154 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220221616 | ARDANUY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | INNOVIM, LLC (Greenbelt, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Philip ARDANUY (Greenbelt, Maryland); Sibren ISAACMAN (Greenbelt, Maryland); Justin HICKS (Greenbelt, Maryland); Ethan CARTON (Greenbelt, Maryland) |
| ABSTRACT | The invention describes a new and improved weather forecasting model which utilizes neural networks to execute equations which use timed inputs from current weather forecasting models to produce more accurate weather predictions. By innovatively combining several independent techniques through Machine Learning (ML), the LEARN2 decision support tool can improve heavy precipitation forecast skill in Week 1 and extend the duration of skillful forecasts two additional days into Week 2, as measured by accuracy and precision against verification observations—beyond that presently available from today's operational GFS and GEFS predictions alone. The LEARN2 predictions, while based upon the precipitation and atmospheric field forecasts of the GFS or GEFS, add in three significant additional information sources: (1) remotely sensed satellite observations untainted by the data assimilation analyses conducted by NWP centers as a part of each forecast's initialization. While allowing the models to better assimilate the observations, there is an unavoidable loss of in-formation—information that these observed fields still retain; (2) sub-seasonal-to-seasonal (S2S) teleconnection indices, which pro-vide information on global circulation patterns that modulate synoptic meteorology; and (3) assessments of NWP model forecast biases, obtained from a sequence of forecasts and their verifications. Operational NWP models have inherent biases that must be removed either objectively or subjectively before use. |
| FILED | Monday, January 10, 2022 |
| APPL NO | 17/572534 |
| CURRENT CPC | Meteorology G01W 1/00 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/0454 (20130101) G06N 3/0481 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of the Interior (DOI)
| US 20220220372 | Rand et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF PRINCETON UNIVERSITY (Princeton, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Barry Rand (Princeton, New Jersey); Ross Kerner (Princeton, New Jersey); Zhengguo Xiao (Plainsboro, New Jersey) |
| ABSTRACT | Organic-inorganic perovskite nanoparticle compositions are described herein. In some embodiments, a nanoparticle composition comprises a layer of organic-inorganic perovskite nanocrystals, the organic-inorganic perovskite nanocrystals comprising surfaces associated with ligands of size unable to incorporate into octahedral corner sites of the perovskite crystal structure. |
| FILED | Wednesday, September 08, 2021 |
| APPL NO | 17/469429 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) Original (OR) Class C09K 11/025 (20130101) Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 7/14 (20130101) C30B 29/12 (20130101) C30B 29/60 (20130101) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 9/2009 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0077 (20130101) H01L 51/4253 (20130101) H01L 51/5032 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of the Treasury (TREASURY)
| US 20220221735 | Rich et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | WAVEFRONT TECHNOLOGY, INC. (Paramount, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Chapman Rich (Rancho Palos Verdes, California); Joel Mikael Petersen (Valley Village, California); Roger Winston Phillips (Santa Rosa, California); John Michael Tamkin (Pasadena, California) |
| ABSTRACT | An optical device includes an array of lenses and a plurality of segments disposed under the array of lenses. The plurality of segments corresponds to a plurality of images. Upon tilting the device at different viewing angle, the array of lenses presents images sequentially. In some examples, individual ones of the segments can comprise specular reflecting, transparent, diffusely reflecting, and/or diffusely transmissive features. In some examples, individual ones of the segments can comprise transparent and non-transparent regions. The images can produce one or more optical effects. |
| FILED | Friday, August 20, 2021 |
| APPL NO | 17/445580 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 30/27 (20200101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Security Agency (NSA)
| US 20220224639 | Froese et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hewlett Packard Enterprise Development LP (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edwin L. Froese (Burnaby British Columbia, California); Robert L. Alverson (Seattle, Washington); Konstantinos Fragkiadakis (Bristol Avon, United Kingdom) |
| ABSTRACT | Systems and methods are provided for managing multicast data transmission in a network having a plurality of switches arranged in a Dragonfly network topology, including: receiving a multicast transmission at an edge port of a switch and identifying the transmission as a network multicast transmission; creating an entry in a multicast table within the switch; routing the multicast transmission across the network to a plurality of destinations via a plurality of links, wherein at each of the links the multicast table is referenced to determine to which ports the multicast transmission should be forwarded; and changing, when necessary, the virtual channel used by each copy of the multicast transmission as the copy progresses through the network. |
| FILED | Monday, March 23, 2020 |
| APPL NO | 17/594686 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 45/16 (20130101) H04L 45/021 (20130101) H04L 45/42 (20130101) Original (OR) Class H04L 45/566 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Office of the Director of National Intelligence (ODNI)
| US 20220222940 | Rawat et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yogesh Singh Rawat (Orlando, Florida); Mubarak Shah (Orlando, Florida); Aayush Jung Bahadur Rana (Orlando, Florida); Praveen Tirupattur (Orlando, Florida); Mamshad Nayeem Rizve (Orlando, Florida) |
| ABSTRACT | Methods of detecting and categorizing an action in an untrimmed video segment regardless of the scale of the action and the close proximity of other actions. The methods improve upon the prior art which either require trimmed video segments including only a single activity depicted therein, or untrimmed video segments including relatively few actions, persons, or objects of interest, thereby directing the classification. Instead, the methods utilize a plurality of tubelets used to represent discreet actions, persons, and objects of interest within the comprehensive untrimmed video segment. The tubelets are localized to correct for pixel-level foreground-background biases, which are then turned into short spatio-temporal action tubelets that are passed to a classification network to obtain multi-label predictions. After classification, the tubelets are be linked together to obtain the final detections with varying lengths, and the method merges the short action tubelets into final action detections. |
| FILED | Friday, January 07, 2022 |
| APPL NO | 17/647415 |
| CURRENT CPC | Image or Video Recognition or Understanding G06V 20/41 (20220101) Original (OR) Class G06V 20/46 (20220101) G06V 20/49 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
U.S. State Government
| US 20220219014 | Sampayan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California); Opcondys, Inc. (Manteca, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen E. Sampayan (Manteca, California); George James Caporaso (East Quogue, New York); Yu-Jiuan Chen (Fremont, California); Kristin Cortella Sampayan (Manteca, California) |
| ABSTRACT | Methods, devices and systems for ultra-high dose radiotherapy are disclosed. The described techniques rely in-part on active switching control of a photoconductive switch during the time the accelerator is accelerating charged particles to produce the output radiation at the desired dose rates. One radiotherapy system includes a particle accelerator configured to receive charged particles from a pulsed source. The particle accelerator includes a pipe configured to allow the charged particles to pass through as a beam, a magnetic core positioned proximate to the pipe and coupled to the pulsed source, and at least one multilayer insulator positioned adjacent to the pipe and the magnetic core. The system also includes a photoconductive switch coupled to the particle accelerator and configured to supply the particle accelerator with a plurality of voltage pulses. |
| FILED | Thursday, January 13, 2022 |
| APPL NO | 17/575074 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/1048 (20130101) Original (OR) Class A61N 5/1078 (20130101) A61N 2005/1088 (20130101) A61N 2005/1089 (20130101) Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 7/04 (20130101) H05H 7/06 (20130101) H05H 2277/11 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20220221589 | Elgersma et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell International Inc. (Charlotte, North Carolina) |
| ASSIGNEE(S) | Honeywell International Inc. (Charlotte, North Carolina) |
| INVENTOR(S) | Michael Ray Elgersma (Plymouth, Minnesota); Ruth Dagmar Kreichauf (River Falls, Wisconsin) |
| ABSTRACT | Systems and methods for operating a navigation system and detecting GNSS spoofing using a chip-scale atomic clock are provided herein. |
| FILED | Monday, November 08, 2021 |
| APPL NO | 17/521693 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 19/215 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
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Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, July 14, 2022.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20220714.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page