FedInvent™ Patent Applications
Application Details for Thursday, July 28, 2022
This page was updated on Sunday, July 31, 2022 at 05:44 AM GMT
Department of Health and Human Services (HHS)
| US 20220232821 | Pritts et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Cincinnati (Cincinnati, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Timothy A. Pritts (Cincinnati, Ohio); Kasiemobi Pulliam (Cincinnati, Ohio); Bernardin Joseph (Cincinnati, Ohio); Charles Caldwell (Cincinnati, Ohio); Alex B. Lentsch (Cincinnati, Ohio); Amy T. Makley (Cincinnati, Ohio); Michael D. Goodman (Cincinnati, Ohio) |
| ABSTRACT | Solutions are provided herein for the collection of whole blood and/or storage of packed red blood cells, the solutions including one or more inorganic pyrophosphates (PPi). Also provided are methods of storing whole blood or packed red blood cells and methods of mitigating a complication associated with a transfusion or infusion of whole blood or red blood cells, the methods including storing the whole blood or red blood cells in a solution including one or more inorganic pyrophosphates. |
| FILED | Friday, June 05, 2020 |
| APPL NO | 17/617191 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0226 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0641 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220233125 | Ringkamp et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthias Ringkamp (Baltimore, Maryland); Gang Wu (Princeton, New Jersey); Gene Yevgeny Fridman (Baltimore, Maryland) |
| ABSTRACT | The present invention is directed to an electrode system for recording nerve action potential (NAP) from surgically exposed nerve and methods for using such an electrode system. Electrophysiological methods are used during repair surgery of peripheral nerve trauma (PNT). PNT is a major medical problem with an annual incidence similar to that of epilepsy. Surgical intervention is provided based on the severity of nerve injury which is determined preoperatively and intraoperatively mainly by electrophysiological assessments. Among those, intraoperative nerve action potential (NAP) or compound action potential (CNAP) recording is preferred for direct assessment of functional continuity of the nerve. |
| FILED | Monday, June 08, 2020 |
| APPL NO | 17/617233 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/294 (20210101) Original (OR) Class A61B 5/296 (20210101) A61B 5/395 (20210101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0408 (20130101) A61N 1/0476 (20130101) A61N 1/0558 (20130101) A61N 1/3605 (20130101) A61N 1/36014 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220233133 | Ginty et al. |
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| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David D. Ginty (Cambridge, Massachusetts); Lauren L. Orefice (Cambridge, Massachusetts) |
| ABSTRACT | In some aspects, the disclosure relates to a prepulse inhibition (PPI) assay comprising the steps of, administering a tactile prepulse to a human subject, administering a startle stimulus to the subject, and measuring the subject's response to the startle stimulus. In another aspect, the disclosure relates to a method for evaluating tactile hypersensitivity and/or sensorimotor impairment in a human subject, comprising, administering to the subject a PPI assay according to any one of the preceding claims, comparing the assay results to neuro-typical controls, and determining the degree of tactile hypersensitivity and/or sensorimotor impairment in the subject. |
| FILED | Thursday, May 21, 2020 |
| APPL NO | 17/612855 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/112 (20130101) A61B 5/395 (20210101) A61B 5/0533 (20130101) A61B 5/4035 (20130101) Original (OR) Class A61B 5/4842 (20130101) A61B 5/4848 (20130101) A61B 2503/06 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220233413 | Di Carlo et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Dino Di Carlo (Los Angeles, California); Chueh-Yu Wu (Los Angeles, California); Andrea L. Bertozzi (Los Angeles, California); Bao Wang (Los Angeles, California); Joseph de Rutte (Los Angeles, California); Kyung HA (Los Angeles, California) |
| ABSTRACT | An emulsion system includes a plurality of monodisperse particle-drops. Each particle-drop is formed by a single elongated drop-carrier particle disposed in an oil-based continuous phase, wherein the single elongated drop-carrier particle comprises an elongate body with an opening at one end thereof. The single elongated drop-carrier particle has a hydrophilic interior region containing an aqueous droplet and a hydrophobic exterior region. The aqueous droplet and/or a surface of the hydrophilic interior region may contain one or more reagents, analytes, labels, reporter molecules, and/or cells. |
| FILED | Tuesday, May 05, 2020 |
| APPL NO | 17/609384 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 8/06 (20130101) Original (OR) Class A61K 8/0241 (20130101) A61K 2800/10 (20130101) A61K 2800/412 (20130101) A61K 2800/612 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220233443 | Imai et al. |
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| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Shin-Ichiro Imai (St. Louis, Missouri); Mitsukuni Yoshida (St. Louis, Missouri) |
| ABSTRACT | The present invention relates to various compositions comprising NAMPT and/or mutant thereof, processes for preparing these compositions, and various methods of using these compositions to prevent or treat an age-associated condition in a subject. The present invention also relates to methods of increasing NMN and/or NAD+ biosynthesis in a cell. |
| FILED | Monday, June 08, 2020 |
| APPL NO | 17/617245 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1271 (20130101) Original (OR) Class A61K 9/1277 (20130101) A61K 38/45 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) A61P 25/00 (20180101) A61P 25/20 (20180101) Enzymes C12Y 204/02012 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220233479 | FORSTER et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER (Fort Worth, Texas) |
| ASSIGNEE(S) | UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER (Fort Worth, Texas) |
| INVENTOR(S) | Michael J. FORSTER (Fort Worth, Texas); Ritu A. SHETTY (Fort Worth, Texas); Jacques NGUYEN (Fort Worth, Texas); Liang-Jun YAN (Fort Worth, Texas) |
| ABSTRACT | Certain embodiments are directed to methods of treating or preventing an addictive behavior in a subject, said method comprising administering to said subject an effective amount of a DMTU or a composition comprising same. |
| FILED | Friday, July 17, 2020 |
| APPL NO | 17/628138 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/17 (20130101) Original (OR) Class A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220233490 | Garza et al. |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Battimore, Maryland) |
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| INVENTOR(S) | Luis Garza (Baltimore, Maryland); Dongwon Kim (Baltimore, Maryland) |
| ABSTRACT | The present invention relates to the field of skin rejuvenation. Specifically, the present invention provides compositions and methods for promoting skin rejuvenation using a toll-like receptor 3 (TLR3) agonist and retinoic acid or derivatives thereof. In a specific embodiment, a method for treating wrinkles in a subject comprises the steps of (a) administering to the area of the subject comprising a wrinkle a composition comprising an effective amount of retinoic acid or a derivative thereof; and administering to the area of the subject comprising a wrinkle a composition comprising an effective amount of a TLR3 agonist. |
| FILED | Thursday, May 14, 2020 |
| APPL NO | 17/611752 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 8/361 (20130101) A61K 8/606 (20130101) A61K 31/203 (20130101) Original (OR) Class A61K 31/713 (20130101) A61K 31/5585 (20130101) A61K 38/1729 (20130101) A61K 2800/91 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/02 (20180101) A61P 17/14 (20180101) Specific Use of Cosmetics or Similar Toilet Preparations A61Q 19/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220233498 | Gross et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric Gross (Menlo Park, California); Daria Mochly-Rosen (Menlo Park, California); Stacy Lynn McAllister (Redwood City, California) |
| ABSTRACT | Methods and compositions are provided for treating endometriosis in an individual, and the pain associated with endometriosis. Aspects of the methods include administering to the individual an agent that promotes ALDH activity. |
| FILED | Friday, February 25, 2022 |
| APPL NO | 17/681591 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/0024 (20130101) A61K 31/36 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220233511 | Hogenesch et al. |
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| FUNDED BY |
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| APPLICANT(S) | CHILDREN'S HOSPITAL MEDICAL CENTER (Cincinnati, Ohio) |
| ASSIGNEE(S) | CHILDREN'S HOSPITAL MEDICAL CENTER (Cincinnati, Ohio) |
| INVENTOR(S) | John Hogenesch (Cincinnati, Ohio); Carlos Prada (Cincinnati, Ohio) |
| ABSTRACT | Methods for alleviating symptoms in a Smith Kingsmore Syndrome (SKS) patient using low doses of a mTOR inhibitor. Also provided herein are methods to determine suitable doses of a mTOR inhibitor for a SKS patient to alleviate at least one symptom associated with SKS with little or no negative impact on behavior features such as the sleep pattern of the SKS patient. |
| FILED | Friday, May 29, 2020 |
| APPL NO | 17/614943 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/436 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220233535 | Yi et al. |
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| APPLICANT(S) | Georgetown University (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chunling Yi (Washington, District of Columbia); Shannon M. White (Arlington, Virginia); Jeffrey Field (Philadelphia, Pennsylvania) |
| ABSTRACT | Methods of treating or preventing cancer, or treating or preventing noncancerous tumors or lesions, in a subject in need thereof. The methods involve administering a therapeutically effective amount of one or more inhibitors of the YAP/TAZ pathway to the subject. In addition, methods of inhibiting or preventing glycolysis in cancer cells in a subject, promoting mitochondrial respiration in cancer cells in a subject, and promoting oxidative stress in cancer cells in a subject, by administering a therapeutically effective amount of one or more inhibitors of the YAP/TAZ pathway to the subject. |
| FILED | Sunday, April 26, 2020 |
| APPL NO | 17/608981 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/18 (20130101) A61K 31/137 (20130101) A61K 31/407 (20130101) A61K 31/409 (20130101) A61K 31/427 (20130101) A61K 31/506 (20130101) Original (OR) Class A61K 31/519 (20130101) A61K 31/4184 (20130101) A61K 31/4523 (20130101) A61K 31/4725 (20130101) A61K 31/4745 (20130101) A61K 38/4893 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220233542 | NORRIS et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Georgia Research Foundation (Athens, Georgia) |
| ASSIGNEE(S) | University of Georgia Research Foundation (Athens, Georgia) |
| INVENTOR(S) | Karen A. NORRIS (Athens, Georgia); Finja SCHWEITZER (Athens, Georgia); Whitney RABACAL (Athens, Georgia) |
| ABSTRACT | Provided herein are compositions comprising one or more statins and one or more antiretroviral agents, as well as therapeutic or prophylactic treatment methods featuring such combinations. The described compositions and methods are beneficial for treating or preventing human immunodeficiency virus (HIV)-associated pulmonary arterial hypertension (PAH), related conditions, and the symptoms thereof. |
| FILED | Tuesday, June 02, 2020 |
| APPL NO | 17/616502 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/40 (20130101) A61K 31/513 (20130101) Original (OR) Class A61K 31/683 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/12 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220233545 | Gray et al. |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Brooklin, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nathanael S. Gray (Jamaica Plain, Massachusetts); David A. Scott (Newton, Massachusetts); Thomas Gero (Stow, Massachusetts); Michael Eck (Brookline, Massachusetts); David Heppner (Brookline, Massachusetts); Tyler Beyett (Brookline, Massachusetts); Ciric To (Medford, Massachusetts) |
| ABSTRACT | The disclosure relates to compounds that act as an allosteric inhibitors of epidermal growth factor receptor (EGFR); pharmaceutical compositions comprising the compounds; and methods of treating or preventing kinase-mediated disorders, including cancer and other proliferation diseases. |
| FILED | Friday, June 19, 2020 |
| APPL NO | 17/596639 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/496 (20130101) A61K 31/502 (20130101) A61K 31/506 (20130101) A61K 31/517 (20130101) A61K 31/519 (20130101) Original (OR) Class A61K 31/4725 (20130101) A61K 31/5377 (20130101) A61K 39/3955 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 401/10 (20130101) C07D 401/12 (20130101) C07D 401/14 (20130101) C07D 403/12 (20130101) C07D 403/14 (20130101) C07D 417/12 (20130101) C07D 417/14 (20130101) C07D 471/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220233549 | COBURN et al. |
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| APPLICANT(S) | Venatorx Pharmaceuticals, Inc (Malvern, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Glen A. COBURN (Bethel, Connecticut); Guo-Hua CHU (Exton, Pennsylvania); Jodie C. HAMRICK (New Holland, Pennsylvania); Charlotte L. BOWSHER (Phoenixville, Pennsylvania); Daniel C. PEVEAR (Downingtown, Pennsylvania) |
| ABSTRACT | Described herein are compounds that are useful in treating an alphavirus infection. In some embodiments, the alphavirus is the Chikungunya virus. |
| FILED | Thursday, May 07, 2020 |
| APPL NO | 17/609654 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/55 (20130101) A61K 31/542 (20130101) Original (OR) Class A61K 31/4375 (20130101) A61K 31/4985 (20130101) A61K 31/5383 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220233554 | Kang et al. |
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| APPLICANT(S) | Texas Tech University System (Lubbock, Texas) |
| ASSIGNEE(S) | Texas Tech University System (Lubbock, Texas) |
| INVENTOR(S) | Min H. Kang (Lubbock, Texas); Sung-Jen Wei (Lubbock, Texas); Charles P. Reynolds (Lubbock, Texas) |
| ABSTRACT | Embodiments of the present disclosure pertain to methods of treating a cancer in a subject by administering to the subject a compound that inhibits interaction between octamer-binding transcription factor 4 (OCT4) and Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2), OCT4 and DNA-dependent protein kinase catalytic subunit (DNA-PKcs), or combinations thereof. Additional embodiments of the present disclosure pertain to the compounds of the present disclosure. Further embodiments of the present disclosure pertain to methods of inhibiting interaction between OCT4 and MAPKAPK2 and/or OCT4 and DNA-PKcs by exposing protein complexes to the compounds of the present disclosure. Additional embodiments of the present disclosure pertain to methods of screening potential inhibitors of protein-protein interaction between a first protein and a second protein. |
| FILED | Tuesday, February 08, 2022 |
| APPL NO | 17/667000 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/53 (20130101) A61K 31/58 (20130101) Original (OR) Class A61K 31/357 (20130101) A61K 31/437 (20130101) A61K 31/506 (20130101) A61K 31/4355 (20130101) A61K 31/7048 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 35/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220233563 | Crabtree et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Gerald R. Crabtree (Woodside, California); Christina Curtis (Stanford, California); Jose A. Seoane Fernandez (Stanford, California); Jacob G. Kirkland (East Palo Alto, California) |
| ABSTRACT | Methods of treatment based on a neoplasm's responsiveness to anthracycline are provided. Chromatin accessibility or expression levels of chromatin regulatory genes are used in some instances to determine whether a neoplasm will respond to anthracycline treatment. Anthracyclines are utilized to treat various individuals' neoplasms and cancers, as determined by their anthracycline responsiveness. |
| FILED | Monday, March 30, 2020 |
| APPL NO | 17/600004 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/136 (20130101) A61K 31/138 (20130101) A61K 31/337 (20130101) A61K 31/513 (20130101) A61K 31/519 (20130101) A61K 31/565 (20130101) A61K 31/675 (20130101) A61K 31/704 (20130101) Original (OR) Class A61K 31/4745 (20130101) A61K 31/5545 (20170801) A61K 31/7068 (20130101) A61K 33/243 (20190101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220233573 | SIMONS |
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| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael SIMONS (New Haven, Connecticut) |
| ABSTRACT | In various aspects and embodiments, the invention provides methods of treating pulmonary arterial hypertension by inhibiting the endothelial to mesenchymal transition. The invention provides a method of treating pulmonary arterial hypertension (PAH) in a subject, the method comprising administering to the subject an agent that modulates the activity or level of let-7 mlRNA in an endothelial cell in the subject, thereby treating PAH in the subject. In another aspect, the invention provide a method of treating PAH in a subject, the method comprising administering to the subject an agent that decreases the activity or level of an endothelial TGFβ signaling polypeptide or a TGFβ peptide receptor, thereby treating PAH in the subject. |
| FILED | Tuesday, July 14, 2020 |
| APPL NO | 17/626581 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/436 (20130101) A61K 31/713 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/00 (20180101) A61P 9/02 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2310/141 (20130101) C12N 2310/321 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220233576 | BOEHNKE et al. |
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| APPLICANT(S) | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Natalie BOEHNKE (Cambridge, Massachusetts); Joelle Payne STRAEHLA (Cambridge, Massachusetts); Angela KOEHLER (Cambridge, Massachusetts); Paula HAMMOND (Cambridge, Massachusetts) |
| ABSTRACT | SLC46A3 has been identified as a lipid-based nanoparticle-specific biomarker predictive of nanoparticle-cancer cell affinity. SLC46A3 has a strong inverse association with lipid-based nanoparticle uptake across multiple nanoparticle formulations. Tissues with decreased expression levels of SLC46A3 have a greater uptake of lipid-based nanoparticles. The inverse relationship of SLC46A3 expression in tumor tissue and affinity for lipid-based nanoparticles has therapeutic and diagnostic implications, including cancer therapy and diagnosis, and identification of patients most likely to benefit from a lipid-based nanotherapeutic for improved stratification in clinical trials. |
| FILED | Monday, January 24, 2022 |
| APPL NO | 17/582594 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1271 (20130101) A61K 9/1617 (20130101) A61K 9/1635 (20130101) A61K 9/1647 (20130101) A61K 31/7105 (20130101) Original (OR) Class A61K 38/465 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1135 (20130101) C12N 2320/34 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220233594 | SUN et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University ofTexas System (Austin, Texas) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Shao-Cong SUN (Houston, Texas); Xiaofei ZHOU (Houston, Texas) |
| ABSTRACT | The present disclosure provides methods for generating Otub 1 deficient T cells and natural killer (NK) cells and compositions comprising engineered T cells expressing a reduced amount of Otub 1. Further provided are methods of treating cancer comprising administering the Otub 1 deficient T cells and/or NK cells to a subject in need thereof. |
| FILED | Thursday, May 07, 2020 |
| APPL NO | 17/609507 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/675 (20130101) A61K 31/7076 (20130101) A61K 35/17 (20130101) Original (OR) Class A61K 38/1774 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 37/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220233598 | Shin et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa) |
| ASSIGNEE(S) | UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa) |
| INVENTOR(S) | Kyungsup Shin (Iowa City, Iowa); Dong Rim Seol (Iowa City, Iowa); James A. Martin (Iowa City, Iowa); Ino Song (Iowa City, Iowa) |
| ABSTRACT | In certain embodiments, the present invention provides a method for preventing or treating post-traumatic osteoarthritis (PTOA) in the temporomandibular joint (TMJ) in a subject in need thereof, comprising administrating a pharmaceutical composition comprising an effective amount of mesenchymal stem cell-derived exosomes or mesenchymal stem cell-derived exosomal microRNA to the subject. In certain embodiments, the present invention provides a method for preventing progressive fibrocartilage degeneration in a subject in need thereof, comprising administrating a pharmaceutical composition comprising an effective amount of mesenchymal stem cell-derived exosomes or mesenchymal stem cell-derived exosomal microRNA to the subject. |
| FILED | Wednesday, January 26, 2022 |
| APPL NO | 17/585094 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 35/28 (20130101) Original (OR) Class A61K 47/6903 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220233604 | Yang et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Phillip C. Yang (Stanford, California); Gentaro Ikeda (Los Altos, California); Connor Galen O'Brien (Palo Alto, California) |
| ABSTRACT | Provided herein are compositions and methods for the restoration of intracellular bioenergy in disorders characterized by intracellular bioenergetics imbalance. Specifically, compositions and methods provided herein include extracellular vesicles that include mitochondria and/or mitochondrial fragments. |
| FILED | Thursday, May 14, 2020 |
| APPL NO | 17/611272 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/127 (20130101) A61K 35/34 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/00 (20180101) A61P 39/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0657 (20130101) C12N 2501/415 (20130101) C12N 2506/45 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220233611 | Hsiao et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elaine Y. Hsiao (Los Angeles, California); Helen E. Vuong (Los Angeles, California) |
| ABSTRACT | Disclosed herein are methods for promoting healthy neural development in an unborn baby, which include administering to a maternal subject gestating the unborn baby a composition or a bacterial composition. Compositions can include trimethylamine N-oxide (TMAO), 5-aminovalerate (5-AV), imidazole propionate (IP), hippurate (HIP), or a combination thereof, and the bacterial compositions can include bacteria of the order Clostridiales. Also disclosed are methods for conditioning a female subject for bringing about offspring with healthy neural development. Additionally disclosed are methods for reducing adverse effects of antibiotic treatment on an unborn baby in a pregnant subject. Also disclosed are methods for selecting a female subject for conditioning to foster healthy neural development in offspring. |
| FILED | Thursday, October 31, 2019 |
| APPL NO | 17/609269 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/04 (20130101) A61K 31/197 (20130101) A61K 31/198 (20130101) A61K 31/4166 (20130101) A61K 35/741 (20130101) A61K 35/742 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220233615 | Hatfull et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Graham Hatfull (Pittsburgh, Pennsylvania); Rebekah Dedrick (Glenshaw, Pennsylvania); Carlos Guerrero (Pittsburgh, Pennsylvania) |
| ABSTRACT | The invention provides a composition (e.g., pharmaceutical composition) comprising a combination of two or more phages, wherein the phages are two or more of: (a) phage D29; (b) phage AdephagiaΔ41Δ43; (c) phage FionnbharthΔ47; (d) phage Fred313cpm-1; and (e) phage MuddyHRMN0052-1; and a pharmaceutically acceptable carrier. The invention provides a method of treating, reducing, or preventing a disease caused by Mycobacterium tuberculosis in a mammal comprising administering a pharmaceutical composition comprising a combination of two or more phages wherein the phages are two or more of: (a) phage D29; (b) phage AdephagiaΔ41Δ43; (c) phage FionnbharthΔ47; (d) phage Fred313cpm-1; and (e) phage MuddyHRMN0052-1; and a pharmaceutically acceptable carrier. The composition can be administered alone or in combination with one or more antibiotics, wherein the length of treatment is reduced as compared to the length of treatment with one or more antibiotics alone. |
| FILED | Thursday, May 21, 2020 |
| APPL NO | 17/612926 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/76 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/06 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/74 (20130101) C12N 2795/10321 (20130101) C12N 2795/10332 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220233640 | Demorrow et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United State Govermment as represented by the Department of Veterans (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sharon Demorrow (Temple, Texas); Matthew McMillin (Harker Heights, Texas); Anca D. Petrescu (Temple, Texas) |
| ABSTRACT | In one aspect, the invention relates to pharmaceutical compositions comprising at least one agent that modulates GalR1 and/or GalR, which are useful for treating fibrotic disorders such as, for example, liver fibrosis. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| FILED | Thursday, April 16, 2020 |
| APPL NO | 17/604370 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1138 (20130101) C12N 2310/14 (20130101) C12N 2310/3233 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220233641 | KAMBAYASHI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Taku KAMBAYASHI (Malvern, Pennsylvania); Ruth CHOA (Ellicott City, Maryland) |
| ABSTRACT | Compositions and methods for treating and/or ameliorating obesity are provided. In certain embodiments, the compositions comprise the topical vitamin D3 derivative MC903. In other embodiments, the compositions systemically increase TSLP levels in a subject. In yet other embodiments, the compositions include TSLP peptide isoforms and/or adeno-associated viral vectors containing TSLP-expressing sequences. Methods using these compositions increase TSLP levels in the subject and cause selective loss of white adipose tissue without loss in muscle mass. |
| FILED | Monday, May 18, 2020 |
| APPL NO | 17/611309 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/593 (20130101) A61K 38/19 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) A61P 3/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2750/14143 (20130101) C12N 2750/14171 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220233643 | JIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (GAINESVILLE, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lei JIN (Gainesville, Florida); Samira MANSOURI (Gainesville, Florida) |
| ABSTRACT | Provided herein are compositions and methods for treating an inflammatory respiratory disorder. Exemplified are compositions comprising interferon-beta of IFN-beta-fusion peptides. |
| FILED | Thursday, February 13, 2020 |
| APPL NO | 17/430906 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0073 (20130101) A61K 38/191 (20130101) A61K 38/215 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/06 (20180101) A61P 37/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220233659 | Daniell et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania); UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (Gainesville, Florida) |
| ASSIGNEE(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania); UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (Gainesville, Florida) |
| INVENTOR(S) | Henry Daniell (Media, Pennsylvania); Qiuhong Li (Gainesville, Florida); Mohan K. Raizada (Alachua, Florida) |
| ABSTRACT | Emerging evidence indicates that diminished activity of the vasoprotective axis of the renin-angiotensin system, constituting angiotensin converting enzyme2 (ACE2) and its enzymatic product, angiotensin-(1-7) [Ang-(1-7)] contribute to pulmonary hypertension (PH). However, clinical success for long-term delivery of ACE2 or Ang-(1-7) would require stability and ease of administration to increase patient compliance. Chloroplast expression of therapeutic proteins enables their bioencapsulation within plant cells to protect from acids and gastric enzymes; fusion to a transmucosal carrier facilitates effective systemic absorption. Oral feeding of rats with bioencapsulated ACE2 or Ang-(1-7) attenuated monocrotaline (MCT)-induced increase in right ventricular systolic pressure, decreased pulmonary vessel wall thickness and improved right heart function in both prevention and reversal protocols. Furthermore, combination of ACE2 and Ang-(1-7) augmented the beneficial effects against cardio-pulmonary pathophysiology induced by MCT administration. Experiments have also been performed which indicate that this approach is also suitable for the treatment or inhibition of experimental uveitis and autoimmune uveoretinitis These studies provide proof-of-concept for a novel low-cost oral ACE2 or Ang-(1-7) delivery system using transplastomic technology for pulmonary and ocular disease therapeutics. |
| FILED | Wednesday, February 02, 2022 |
| APPL NO | 17/591151 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/19 (20130101) A61K 9/0053 (20130101) A61K 9/1664 (20130101) A61K 9/5063 (20130101) A61K 36/23 (20130101) A61K 36/28 (20130101) A61K 36/31 (20130101) A61K 38/22 (20130101) A61K 38/164 (20130101) A61K 38/4813 (20130101) Original (OR) Class A61K 47/65 (20170801) A61K 47/6415 (20170801) Peptides C07K 14/28 (20130101) C07K 2319/55 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/485 (20130101) C12N 15/8214 (20130101) C12N 15/8257 (20130101) Enzymes C12Y 304/15001 (20130101) C12Y 304/17023 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220233680 | Morrison |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Trudy G. Morrison (Northborough, Massachusetts) |
| ABSTRACT | The invention provides methods for using virus-like particle (VLP) vaccines containing a stabilized pre-fusion respiratory syncytial virus (RSV) F protein to stimulate RSV neutralizing antibodies in pre-immune subjects. In one embodiment, the invention provides a method for immunizing a mammalian subject in need of immunizing against Respiratory Syncytial virus (RSV) infection, comprising, a) providing i) a pre-immune mammalian subject containing RSV neutralizing antibodies, ii) a first composition comprising recombinant chimeric Newcastle disease virus-like particles (ND VLPs), that contain a chimeric protein comprising, in N operable combination, 1) stabilized pre-fusion RSV F protein ectodomain, 2) transmembrane (TM) domain of NDV F protein, and 3) cytoplasmic (CT) domain of NDV F protein, and b) administering an immunologically effective amount of the first composition to the pre-immune subject to produce an immunized subject that comprises an increase in the level of the RSV neutralizing antibodies compared to the level of RSV neutralizing antibodies in the pre-immune subject. In one embodiment, the level of the RSV neutralizing antibodies in the pre-immune subject does not prevent RSV infection of the pre-immune subject. |
| FILED | Tuesday, February 22, 2022 |
| APPL NO | 17/677399 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/17 (20130101) Original (OR) Class A61K 2039/5256 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220233714 | Uddin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | MD Imam Uddin (Nashville, Tennessee); John S. Penn (Brentwood, Tennessee); Gary W. McCollum (Joelton, Tennessee) |
| ABSTRACT | The present disclosure relates to nanoparticles and methods for detecting nucleic acids and methods of inhibiting mRNA expression. |
| FILED | Thursday, January 27, 2022 |
| APPL NO | 17/586560 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/712 (20130101) A61K 31/7125 (20130101) A61K 47/6929 (20170801) Original (OR) Class Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2310/11 (20130101) C12N 2310/321 (20130101) C12N 2310/531 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220233720 | Gao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | University of Massachusetts (Boston, Massachusetts) |
| INVENTOR(S) | Guangping Gao (Westboroug, Massachusetts); Hemant Khanna (Sutton, Massachusetts) |
| ABSTRACT | Aspects of the disclosure relate to compositions and methods useful for treating ocular ciliopathies, for example Leber congenital amaurosis (LCA). In some embodiments, the disclosure provides isolated nucleic acids comprising a transgene encoding a CEP290 protein fragment, and methods of treating ocular ciliopathies using the same. |
| FILED | Tuesday, May 19, 2020 |
| APPL NO | 17/612653 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/76 (20130101) A61K 48/0058 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) Peptides C07K 14/705 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0621 (20130101) C12N 7/00 (20130101) C12N 15/86 (20130101) C12N 15/113 (20130101) C12N 2310/10 (20130101) C12N 2750/14122 (20130101) C12N 2750/14142 (20130101) C12N 2830/008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220233727 | Thakor et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Avnesh S. Thakor (Redwood City, California); Mehdi Razavi (Redwood City, California) |
| ABSTRACT | Surface enhanced Raman scattering (SERS) nanoparticles and methods of using them for detecting reactive oxygen species are disclosed. In particular, methods of using SERS nanoparticles to detect and quantify reactive oxygen species Synthesis and monitor oxidative stress and disease-relevant changes in levels of reactive oxygen species are provided. |
| FILED | Wednesday, June 10, 2020 |
| APPL NO | 17/617462 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0075 (20130101) A61B 6/481 (20130101) A61B 6/4057 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 49/0041 (20130101) A61K 49/0056 (20130101) A61K 49/0093 (20130101) A61K 51/088 (20130101) Original (OR) Class A61K 51/1244 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/658 (20130101) G01N 33/574 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220233743 | WOOLARD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| ASSIGNEE(S) | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| INVENTOR(S) | Matthew WOOLARD (Shreveport, Louisiana); Robert SCHILKE (Shreveport, Louisiana); Cassidy BLACKBURN (Shreveport, None) |
| ABSTRACT | A composition for wound healing, comprising an amount of a macrophage proresolving polarizer, wherein the amount is effective to promote wound healing. The composition includes wherein the macrophage proresolving polarizer is lipin-1. The composition includes wherein the composition includes one, two, or three of IL-4, apoptotic cells (ACs), and AC derived lipids. The composition includes wherein the macrophage proresolving polarizer is a lipin-1 transcriptional coregulatory activity promoter. The composition includes, wherein the lipin-1 transcriptional coregulatory activity promoter is an inhibitor of lipin-1 macrophage pro-inflammatory responses enzymatic activity. A method for promoting wound healing, comprising contacting a wound on a skin of a mammal with the composition. A kit comprising one or more containers including the composition in sterile packaging. A wound healing device comprising a substrate and an amount of an amount of a macrophage proresolving polarizer, wherein the amount is effective to promote wound healing. |
| FILED | Monday, December 14, 2020 |
| APPL NO | 17/121685 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 13/00042 (20130101) A61F 13/00063 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 15/28 (20130101) A61L 15/44 (20130101) Original (OR) Class A61L 2300/404 (20130101) A61L 2400/04 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220233770 | Vezeridis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander Michael Vezeridis (Los Altos, California); Bruce L. Daniel (Stanford, California); Lawrence V. Hofmann (Stanford, California) |
| ABSTRACT | A method of monitoring a fluid injection procedure is provided. The method includes: disposing a sensor on a catheter, where the sensor is in proximity to a tip of the catheter; inserting at least the tip of the catheter into a patient; delivering a fluid to a location within the patient via the tip of the catheter; and automatically monitoring a sensor signal from the sensor while the fluid is being delivered. Reflux end-point detection using an electrical impedance sensor has been demonstrated in a phantom. Applications include embolotherapy and angiography. |
| FILED | Monday, January 24, 2022 |
| APPL NO | 17/582677 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/007 (20130101) A61M 5/16836 (20130101) Original (OR) Class A61M 2205/3317 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 2005/1021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220233819 | Charpie et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Charpie (Ann Arbor, Michigan); Adrienne R. Harris (Clinton, Michigan); Shepherd Smith (Milan, Michigan); Kegan McArthur (Saline, Michigan); Gene Parunak (Saline, Michigan) |
| ABSTRACT | A repositionable medical tube, such as an endotracheal tube, a nasogastric tube, or a nasojejunal tube, having an inflatable cuff with at least one divot region therein, the divot region having an outer diameter sufficiently smaller than an outer diameter of both a proximate cuff region and of a distal cuff region as to produce a discernibly-distinct ultrasonic image when scanned by an ultrasound sensor. The medical tube may be further provided with an ultrasonically-detectable coil or one or more ultrasonically-detectable markers having an identifiable geometric shape when the marker is visible using an ultrasonic probe. |
| FILED | Tuesday, June 09, 2020 |
| APPL NO | 17/617837 |
| CURRENT CPC | Containers Specially Adapted for Medical or Pharmaceutical Purposes; Devices or Methods Specially Adapted for Bringing Pharmaceutical Products into Particular Physical or Administering Forms; Devices for Administering Food or Medicines Orally; Baby Comforters; Devices for Receiving Spittle A61J 15/0003 (20130101) A61J 15/0049 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 16/0438 (20140204) A61M 16/0445 (20140204) A61M 16/0459 (20140204) A61M 25/0108 (20130101) Original (OR) Class A61M 25/1002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220233848 | Gad et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); Scuola lnternazionale Superiore di Studi Avanzati (SISSA) (Trieste, Italy); University of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Parag Gad (Woodland Hills, California); Victor Reggie Edgerton (Los Angeles, California); Giuliano Taccola (Udine, Italy); Evgeniy I. Kreydin (Los Angeles, California) |
| ABSTRACT | In various embodiments electrical stimulators are provided for transcutaneous and/or epidural stimulation. In certain embodiments the stimulator provides one or more channels configured to provide one or more of the following stimulation patterns: i) monophasic electrical stimulation with a DC offset; ii) monophasic electrical stimulation with charge balance; iii) delayed biphasic electrical stimulation with a DC offset; iv) delayed biphasic electrical stimulation with charge balance; v) amplitude modulated dynamic stimulation; and/or vi) frequency modulated dynamic stimulation. |
| FILED | Wednesday, May 20, 2020 |
| APPL NO | 17/611534 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/308 (20210101) A61B 5/313 (20210101) A61B 5/389 (20210101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/06 (20130101) A61N 1/025 (20130101) A61N 1/0456 (20130101) A61N 1/0492 (20130101) A61N 1/0553 (20130101) Original (OR) Class A61N 1/36003 (20130101) A61N 1/36007 (20130101) A61N 1/36031 (20170801) A61N 1/37247 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220233879 | Tsai et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Li-Huei Tsai (Cambridge, Massachusetts); Anthony James Martorell (Cambridge, Massachusetts); Ho-Jun SUK (Cambridge, Massachusetts); Ed BOYDEN (Chestnut Hill, Massachusetts) |
| ABSTRACT | Devices, systems, and methods for a treating dementia or Alzheimer's disease in a subject in need thereof. In one example, combined auditory and visual stimuli having a frequency of about 20 Hz to about 60 Hz, and more specifically about 40 Hz, are non-invasively delivered to the subject to induce synchronized gamma oscillations in at least one brain region of the subject. In particular, pursuant to various treatment and exposure protocols, combined auditory and visual stimulation (as opposed to auditory or visual stimulation alone) promotes a microglia response in the medial prefrontal cortex (mPFC). More generally, combined auditory and visual stimulation induces an extended microglia clustering response in the auditory cortex, the visual cortex, and the mPFC. |
| FILED | Monday, February 07, 2022 |
| APPL NO | 17/666153 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 2021/0022 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/062 (20130101) A61N 5/0618 (20130101) Original (OR) Class A61N 5/0622 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220234989 | Shulman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gerald I. Shulman (East Haven, Connecticut); David A. Spiegel (New Haven, Connecticut) |
| ABSTRACT | The present invention includes DNP derivatives that are useful for preventing or treating a metabolic disease or disorder in a subject in need thereof. In certain embodiments, the subject is further administered at least one additional therapeutic agent. |
| FILED | Tuesday, April 05, 2022 |
| APPL NO | 17/713759 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/085 (20130101) Acyclic or Carbocyclic Compounds C07C 205/37 (20130101) Original (OR) Class Steroids C07J 41/0055 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220234995 | Almo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Albert Einstein College of Medicine (Bronx, New York); Victoria Link Limited (Wellington, New Zealand) |
| ASSIGNEE(S) | Albert Einstein College of Medicine (Bronx, New York); Victoria Link Limited (Wellington, New Zealand) |
| INVENTOR(S) | Steven C. Almo (Pelham, New York); Tyler Grove (Bronx, New York); Lawrence D. Harris (Lower Hutt, New Zealand); Gary B. Evans (Lower Hutt, New Zealand) |
| ABSTRACT | This document discloses a novel class of compounds for inhibiting bacterial growth and treating bacterial infection. The compounds target a key step of the futalosine pathway and therefore are effective for the selective inhibition of certain bacterial species and genera with reduced side effect in comparison with conventional antibiotics. |
| FILED | Wednesday, May 20, 2020 |
| APPL NO | 17/612647 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Acyclic or Carbocyclic Compounds C07C 63/14 (20130101) C07C 229/38 (20130101) Original (OR) Class C07C 323/62 (20130101) Heterocyclic Compounds C07D 213/79 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220235007 | Ogungbe et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Jackson State University (Jackson, Mississippi) |
| ASSIGNEE(S) | Jackson State University (Jackson, Mississippi) |
| INVENTOR(S) | Ifedayo Victor Ogungbe (Clinton, Mississippi); Huaisheng Zhang (Shanghai, China PRC) |
| ABSTRACT | Embodiments and methods for a new class of potent non-peptidic covalent inhibitors of nsP2 cysteine protease that inhibit Venezuelan equine encephalitis virus's (VEEV) replication in neuroblasts are disclosed. More particularly, an acrylate and vinyl sulfone-based chemical series were investigated as promising starting scaffolds against VEEV and as inhibitors of the cysteine protease domain of VEEV's non-structural protein 2 (nsP2). The invention discloses compounds of Formula I and analogues for treatment of VEEV. |
| FILED | Monday, January 25, 2021 |
| APPL NO | 17/156879 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 237/36 (20130101) C07C 317/28 (20130101) Heterocyclic Compounds C07D 209/42 (20130101) C07D 215/06 (20130101) Original (OR) Class C07D 215/18 (20130101) C07D 241/42 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220235042 | STARCZYNOWSKI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CHILDREN'S HOSPITAL MEDICAL CENTER (Cincinnati, Ohio); THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel T. STARCZYNOWSKI (Cincinnati, Ohio); Craig J. Thomas (Gaithersburg, Maryland); Garrett Rhyasen (Burlington, Massachusetts); Katelyn Melgar (Cincinnati, Ohio); Morgan MacKenzie Walker (New Haven, Connecticut); Jian-Kang Jiang (Columbia, Maryland) |
| ABSTRACT | Some embodiments of the invention include inventive compounds (e.g., compounds of Formula (I)) and compositions (e.g., pharmaceutical compositions) which can be used for treating, for example, certain diseases. Some embodiments include methods of using the inventive compound (e.g., in compositions or in pharmaceutical compositions) for administering and treating (e.g., diseases such as head and neck squamous cell carcinoma (HNSCC), cancer, blood disorders, etc.). Additional embodiments provide synergistic combinations of a BCL2 inhibitor with an IRAK inhibiting compound, and methods of using same. |
| FILED | Friday, January 28, 2022 |
| APPL NO | 17/587070 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/496 (20130101) Heterocyclic Compounds C07D 471/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220235072 | FUCHS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio); UNIVERSITY OF NORTH CAROLINA AT GREENSBORO (Greensboro, North Carolina); THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Chicago, Illinois); MYCOSYNTHETIX, INC. (Hillsborough, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Robert FUCHS (Columbus, Ohio); Andrew HUNTSMAN (Fort Jennings, Ohio); Nicholas Hunter OBERLIES (Greensboro, North Carolina); Chiraz Soumia AMRINE (Greensboro, North Carolina); Huzefa RAJA (Greensboro, North Carolina); Joanna BURDETTE (Chicago, Illinois); Cedric PEARCE (Chapel Hill, North Carolina) |
| ABSTRACT | Disclosed herein are compounds, compositions, and methods for inhibiting a histone methyltransferase. The compounds are verticillin derivatives that exhibit anti-proliferative activity against cancer cells. The compounds, compositions, and methods can be used to treat a subject with cancer. |
| FILED | Friday, May 22, 2020 |
| APPL NO | 17/613640 |
| CURRENT CPC | Heterocyclic Compounds C07D 519/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220235088 | Tan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Memorial Sloan-Kettering Cancer Center (New York, New York); The Research Foundation for The State University of New York (Albany, New York) |
| ASSIGNEE(S) | Memorial Sloan-Kettering Cancer Center (New York, New York); The Research Foundation for The State University of New York (Albany, New York) |
| INVENTOR(S) | Derek Shieh Tan (New York, New York); Christopher E. Evans (New York, New York); Peter J. Tonge (Newbury, Berkshire, United Kingdom); Melissa Lynn Boby (New York, New York); Yuanyuan Si (Champaign, Illinois) |
| ABSTRACT | Provided herein are compounds of Formula (I) and pharmaceutically acceptable salts or tautomers thereof which may inhibit adenylate-forming enzymes. Also provided are pharmaceutical compositions, kits, uses, and methods involving the inventive compounds for the treatment and/or prevention of an infectious disease (e.g., bacterial infection (e.g., tuberculosis, methicillin-resistant Staphylococcus aureus)). |
| FILED | Friday, February 07, 2020 |
| APPL NO | 17/429319 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 19/167 (20130101) Original (OR) Class C07H 19/173 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220235101 | Waldman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Whitehead Institute for Biomedical Research (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ben Waldman (Cambridge, Massachusetts); Sebastian Lourido (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure provides genetically altered protozoan parasites comprising a mutation in a bradyzoite formation deficient 1 (BFD1) gene, wherein the mutation inhibits differentiation of the parasite into a bradyzoite. The genetically altered protozoan parasites can be utilized in vaccine compositions and in methods of treating apicomplexan parasite infection. |
| FILED | Saturday, May 30, 2020 |
| APPL NO | 17/595894 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/002 (20130101) A61K 2039/52 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 33/02 (20180101) A61P 37/04 (20180101) Peptides C07K 14/45 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/10 (20130101) C12N 15/74 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220235104 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kun Zhang (La Jolla, California); Yan Wu (La Jolla, California); Amir Dailamy (La Jolla, California); Prashant Mali (La Jolla, California); Daniella McDonald (La Jolla, California); Udit Parekh (La Jolla, California); Michael Hu (La Jolla, California) |
| ABSTRACT | This disclosure relates to methods, polynucleotides, vectors, viral particles, cells, and systems or the engineering of human tissues. One aspect of the disclosure relates to using lineage-specific miRNA binding molecules to bias tissue lineage. Another aspect of the disclosure relates to using lineage-specific transcription factor overexpression to bias tissue lineage. |
| FILED | Wednesday, July 03, 2019 |
| APPL NO | 17/257951 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/522 (20130101) A61K 45/06 (20130101) Peptides C07K 14/4702 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0697 (20130101) C12N 9/22 (20130101) C12N 15/86 (20130101) C12N 15/111 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220235111 | WEISS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael A. WEISS (Indianapolis, Indiana); Michael D. GLIDDEN, II (Cleveland, Ohio); Faramarz ISMAIL-BEIGI (Cleveland, Ohio) |
| ABSTRACT | A single-chain insulin analogue containing (i) diverse amino-acid substitutions at position A14; (ii) wild-type or variant residues at positions A8 and A14; and (ii) an engineered C-domain segment of lengths 4-6 containing a specific set of Alanine substitutions and/or deletions derived from the prototype C-domain sequence Glu-Glu-Gly-Pro-Arg-Arg. The analogue may otherwise be an analogue of a mammalian insulin, such as human insulin, may optionally include standard or non-standard modifications that (i) augment the stability of insulin, (ii) cause a shift in the isoelectric point to enhance or impair the solubility of the protein at neutral pH or (iii) reduce cross-binding of the protein to the Type I IGF receptor. Formulations of the above analogues at successive strengths U-100 to U-1000 in soluble solutions under acidic or neutral pH values (e.g., pH 3.0-4.2 and 6.5-7.8, respectively) and optionally in the presence of zinc ions at a molar ratio of 2.2-10 zinc ions per six insulin analogue monomers. A method of treating a patient with diabetes mellitus comprising the administration of a physiologically effective amount of the protein or a physiologically acceptable salt thereof to a patient. Use of a single-chain insulin analogue of the present invention in an insulin delivery device (such as a pump or pen) is envisioned. |
| FILED | Monday, May 18, 2020 |
| APPL NO | 17/612047 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) Peptides C07K 14/62 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220235119 | Bahar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania); CEDARS-SINAI MEDICAL CENTER (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ivet Bahar (Wexford, Pennsylvania); Hongying Cheng (Pittsburgh, Pennsylvania); She Zhang (Pittsburgh, Pennsylvania); Rebecca Porritt (Sherman Oaks, California); Moshe Arditi (Encino, California) |
| ABSTRACT | Provided herein are methods of treating a COVID-19 infection in a subject, comprising administering to the subject an effective amount of a composition that reduces the superantigen character of SARS-CoV-2 Spike protein. In some embodiments, the compositions are mimetic peptides of the superantigen region. In some embodiments, the compositions are humanized antibodies, such as humanized mAb 6D3, that bind to the superantigen region. |
| FILED | Wednesday, July 14, 2021 |
| APPL NO | 17/375601 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/215 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/1271 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/56 (20130101) C07K 2317/565 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220235120 | Feng et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hanping Feng (Ellicott City, Maryland); Yongrong Zhang (Columbia, Maryland); Zhiyong Yang (West Friendship, Maryland); Hua Yu (Columbia, Maryland); Yifan Zhang (North Potomac, Maryland) |
| ASSIGNEE(S) | University of Maryland, Baltimore (Baltimore, Maryland); FZata, Inc. (Halethorpe, Maryland) |
| INVENTOR(S) | Hanping Feng (Ellicott City, Maryland); Yongrong Zhang (Columbia, Maryland); Zhiyong Yang (West Friendship, Maryland); Hua Yu (Columbia, Maryland); Yifan Zhang (North Potomac, Maryland) |
| ABSTRACT | Novel, antibody-based binding agents derived from camelid VHH and human immunoglobulins are described. These binding agents recognize and bind with specificity to Clostridium difficile toxin A and/or toxin B and in some cases exhibit toxin neutralizing activity. These binding agents can be used to treat or prevent primary and recurrent CDI. The binding agents include humanized VHH peptide monomers, linked groups of humanized VHH peptide monomers, humanized VHH peptide monomers joined to antibody Fc domains, and humanized VHH peptide monomers joined to IgG antibodies. |
| FILED | Wednesday, June 03, 2020 |
| APPL NO | 17/616134 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 16/1282 (20130101) Original (OR) Class C07K 2317/22 (20130101) C07K 2317/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220235143 | SPRIGGS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MEMORIAL SLOAN KETTERING CANCER CENTER (New York, New York); EUREKA THERAPEUTICS, INC. (Emeryville, California) |
| ASSIGNEE(S) | MEMORIAL SLOAN KETTERING CANCER CENTER (New York, New York); EUREKA THERAPEUTICS, INC. (Emeryville, California) |
| INVENTOR(S) | David SPRIGGS (New York, New York); Dharmarao THAPI (New York, New York); Su YAN (College Station, Pennsylvania); Cheng LIU (Emeryville, California) |
| ABSTRACT | Provided herein are compositions, methods, and uses involving anti-Mucin-16 (MUC16) agents that immunospecifically bind an epitope of Mucin-16 (MUC16). Also provided herein are uses and methods for managing, treating, or preventing disorders, such as cancer and diseases associated with positive MUC16 expression. |
| FILED | Thursday, May 07, 2020 |
| APPL NO | 17/609053 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 38/177 (20130101) A61K 38/1774 (20130101) A61K 39/39558 (20130101) A61K 47/6851 (20170801) A61K 51/1045 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 35/04 (20180101) Peptides C07K 14/7051 (20130101) C07K 14/70517 (20130101) C07K 14/70578 (20130101) C07K 16/2809 (20130101) C07K 16/3092 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57496 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220235145 | TSOURKAS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, New York) |
| INVENTOR(S) | Andrew TSOURKAS (Bryn Mawr, Pennsylvania); Burcin ALTUN (Philadelphia, Pennsylvania); Hejia Henry WANG (Philadelphia, Pennsylvania); Feifan YU (Aberdeen, New Jersey) |
| ABSTRACT | The invention relates to proximity-based sortase-mediated protein purification and ligation. Specifically, the invention relates to techniques that links protein expression/purification with conjugation to therapeutic agents, imaging agents, or linkers. |
| FILED | Friday, January 28, 2022 |
| APPL NO | 17/588205 |
| CURRENT CPC | Peptides C07K 1/14 (20130101) C07K 7/06 (20130101) C07K 16/40 (20130101) Original (OR) Class C07K 2317/622 (20130101) C07K 2319/20 (20130101) C07K 2319/21 (20130101) C07K 2319/22 (20130101) C07K 2319/70 (20130101) C07K 2319/73 (20130101) C07K 2319/92 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220235322 | Velasco et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); The Broad Institute, Inc. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Silvia Velasco (Moncrivello, Italy); Paola Arlotta (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure is directed to methods of producing dorsal forebrain organoids having cores with a very low incident of apoptotic and hypoxic cells and having highly similar cell types and cell type prevalence. The present disclosure is also directed to compositions comprising such organoids and the use of such organoids for the screening of agents. |
| FILED | Friday, May 29, 2020 |
| APPL NO | 17/615579 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0618 (20130101) Original (OR) Class C12N 5/0697 (20130101) C12N 2500/02 (20130101) C12N 2501/15 (20130101) C12N 2501/415 (20130101) C12N 2501/727 (20130101) C12N 2506/02 (20130101) C12N 2506/45 (20130101) C12N 2513/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5058 (20130101) G01N 33/5088 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220235340 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| INVENTOR(S) | Feng Zhang (Cambridge, Massachusetts); Han Altae-Tran (Cambridge, Massachusetts) |
| ABSTRACT | The disclosure provides for systems, methods, and compositions for targeting polynucleotides. More particularly, the disclosure provides non-naturally occurring or engineered DNA or RNA-targeting systems comprising a novel DNA or RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA and wherein the CRISPR effector protein is a Cas protein. |
| FILED | Wednesday, May 20, 2020 |
| APPL NO | 17/612504 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/111 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220235345 | Rosen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of CA Office of the President (Oakland, California) |
| ASSIGNEE(S) | Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Laura E. Rosen (Oakland, California); David O. Morgan (Oakland, California) |
| ABSTRACT | Provided herein are polypeptide constructs containing a securin, e.g., a full-length securin or a truncated securin, fused to a separase. The polypeptide constructs may further contain linker peptides, protease recognition sites, and unfoldase recognition sites to facilitate expression and/or purification. Methods for obtaining the polypeptide constructs with active separase activity are also described, as well as methods for identify separase modulator compounds such as separase inhibitors. |
| FILED | Wednesday, June 24, 2020 |
| APPL NO | 17/622318 |
| CURRENT CPC | Peptides C07K 14/47 (20130101) C07K 2319/50 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/6472 (20130101) Original (OR) Class Enzymes C12Y 304/22049 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220235372 | Gao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | University of Massachusetts (Boston, Massachusetts) |
| INVENTOR(S) | Guangping Gao (Westborough, Massachusetts); Phillip Tai (Worcester, Massachusetts); Manish Muhuri (Worcester, Massachusetts); Wei Zhan (Worcester, Massachusetts) |
| ABSTRACT | The disclosure, in some aspects, relates to nucleic acids, compositions and kits useful for gene therapy with reduced immune response to transgene products. |
| FILED | Friday, January 21, 2022 |
| APPL NO | 17/581306 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 15/113 (20130101) C12N 2310/141 (20130101) C12N 2320/32 (20130101) C12N 2330/51 (20130101) C12N 2750/14143 (20130101) C12N 2750/14171 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220235374 | SHEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Brigham and Women`s Hospital, Inc. (Boston, Massachusetts); The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jie SHEN (Brookline, Massachusetts); Raymond J. KELLEHER, III (Brookline, Massachusetts) |
| ABSTRACT | The present disclosure provides, among other things, human codon-optimized sequences encoding presenilin 1, and methods for using the sequences in gene therapy to treat neurodegenerative diseases including, but not limited to Alzheimer's disease, frontotemporal dementia, frontotemporal lobar degeneration, Pick's disease, Lewy body dementia, memory loss, and cognitive impairment including mild cognitive impairment (MCI). |
| FILED | Thursday, May 21, 2020 |
| APPL NO | 17/613612 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Peptides C07K 14/4711 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 2750/14143 (20130101) C12N 2750/14171 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220235382 | Church et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George M. Church (Brookline, Massachusetts); Luhan Yang (Somerville, Massachusetts); Marc Guell (Barcelona, Spain); Joyce Lichi Yang (Cambridge, Massachusetts) |
| ABSTRACT | Methods are provided for altering target DNA in a cell genetically modified to express a Cas 9 enzyme that forms a co-localization complex with a guide RNA complementary to the target DNA and that cleaves the target DNA in a site specific manner Methods include introducing into the cell a first foreign nucleic acid encoding a donor nucleic acid sequence, introducing into the cell from media surrounding the cell the guide RNA complementary to the target DNA and which guides the Cas 9 enzyme to the target DNA, wherein the RNA and the enzyme are members of a co-localization complex for the target DNA, wherein the donor nucleic acid sequence is expressed, wherein the guide RNA and the Cas 9 enzyme co-localize to the target DNA, the Cas 9 enzyme cleaves the target DNA and the donor nucleic acid is inserted into the target DNA to produce altered DNA in the cell. |
| FILED | Thursday, April 07, 2022 |
| APPL NO | 17/715177 |
| CURRENT CPC | Peptides C07K 14/315 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0696 (20130101) C12N 15/85 (20130101) C12N 15/86 (20130101) C12N 15/907 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220235401 | Parveen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | Nikhat Parveen (West Orange, New Jersey); Salvatore A. Marras (Roselle Park, New Jersey) |
| ABSTRACT | The present invention provides novel methods of diagnosing and determining treatment strategies for Lyme disease and other tick-borne illnesses. |
| FILED | Wednesday, April 06, 2022 |
| APPL NO | 17/658201 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) Original (OR) Class C12Q 1/6883 (20130101) C12Q 2600/16 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220235406 | Brower et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Chan Zuckerberg Biohub, Inc. (San Francisco, California); The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kara Brower (Stanford, California); Polly M. Fordyce (Stanford, California); Alexandra Sockell (Stanford, California); Adam K. White (Stanford, California); Yinnian Feng (Stanford, California) |
| ABSTRACT | The invention provides compositions and methods for associating data from phenotypic analysis of a single cell with sequencing data from the single cell using spectrally-encoded microbeads. |
| FILED | Wednesday, May 27, 2020 |
| APPL NO | 17/613892 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6841 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1463 (20130101) G01N 15/1475 (20130101) G01N 15/1484 (20130101) G01N 2015/1497 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220235417 | Noth et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois); The Board of Trustees of the University of Illinois (Urbana, Illinois); University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | The University of Chicago (Chicago, Illinois); The Board of Trustees of the University of Illinois (Urbana, Illinois); University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Imre Noth (Chicago, Illinois); Yong Huang (Dyer, Indiana); Jose David Herazo-Maya (North Haven, Connecticut); Naftali Kaminski (New Haven, Connecticut); Kevin Gibson (Gibsonia, Pennsylvania); Joe G.N. Garcia (Tucson, Arizona) |
| ABSTRACT | Disclosed are methods and kits for evaluating predicting whether an individual IPF has slowly or rapidly progressive IPF. |
| FILED | Monday, March 29, 2021 |
| APPL NO | 17/301187 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/118 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56966 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220236109 | Gratton et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Enrico Gratton (San Clemente, California); Alexander Dvornikov (Irvine, California) |
| ABSTRACT | An imaging system comprises an excitation light source, a directing element positioned to direct light from the excitation light source toward a sample, a detector configured to measure incoming light from the sample, a filter cavity positioned between the sample and the detector, a first filter configured to be inserted into the filter cavity, a sine filter configured to be inserted into the filter cavity, and a processing unit communicatively connected to the detector, configured to receive image data from the detector to form an image. Methods of constructing a hyperspectral image of a sample are also described. |
| FILED | Tuesday, April 19, 2022 |
| APPL NO | 17/723817 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/2803 (20130101) G01J 3/2823 (20130101) Original (OR) Class G01J 3/4406 (20130101) G01J 2003/2826 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/64 (20130101) Pictorial Communication, e.g Television H04N 5/2352 (20130101) H04N 9/04551 (20180801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220236251 | Xie |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Ping Xie (Needham, Massachusetts) |
| ABSTRACT | In a nanopore sensor, a nanopore disposed in a support structure has a nanopore diameter and nanopore resistance, RPore. A fluidic passage, disposed in fluidic connection between a first fluidic reservoir and the nanopore, has a cross-sectional extent, along at least a portion of the fluidic passage length, that is greater than the diameter of the nanopore and that is less than the fluidic passage length. The fluidic passage has a fluidic passage resistance, RFP, of at least about 10% of the nanopore resistance, RPore, and no more than about 10 times the nanopore resistance, RPore. The nanopore is disposed in fluidic connection between the fluidic passage and a second fluidic reservoir. At least one electrical transduction element is disposed at the fluidic passage and electrically connected to produce an indication of electrical potential local to the fluidic passage. |
| FILED | Tuesday, April 12, 2022 |
| APPL NO | 17/718619 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) B01L 3/502715 (20130101) B01L 2300/12 (20130101) B01L 2300/0645 (20130101) B01L 2300/0867 (20130101) B01L 2300/0896 (20130101) B01L 2400/0421 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/4145 (20130101) G01N 27/4146 (20130101) G01N 27/4163 (20130101) G01N 27/4473 (20130101) G01N 27/44726 (20130101) G01N 27/44791 (20130101) G01N 33/48721 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220236264 | Takulapalli |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | iNanoBio Inc. (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bharath Takulapalli (Scottsdale, Arizona) |
| ABSTRACT | The present disclosure provides an improved field effect transistor and device that can be used to sense and characterize a variety of materials. The field effect transistor and/or device including the transistor may be used for a variety of applications, including genome sequencing, protein sequencing, biomolecular sequencing, and detection of ions, molecules, chemicals, biomolecules, metal atoms, polymers, nanoparticles and the like. |
| FILED | Friday, April 15, 2022 |
| APPL NO | 17/722010 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6874 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/414 (20130101) G01N 27/4145 (20130101) G01N 27/4146 (20130101) G01N 33/552 (20130101) G01N 33/48721 (20130101) G01N 33/54366 (20130101) G01N 33/54373 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/30604 (20130101) H01L 29/0665 (20130101) H01L 29/0692 (20130101) H01L 29/1054 (20130101) H01L 29/66666 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220236268 | Mamoun |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Choukri Ben Mamoun (Farmington, Connecticut) |
| ABSTRACT | In various aspects and embodiments, the invention provides a method of detecting a Babesia infection in a subject comprising detecting one or more peptides selected from SEQ ID NOs: 1-62 in a biological sample collected from the subject; wherein detecting one or more of the peptides indicates the presence of Babesia infection. |
| FILED | Friday, June 12, 2020 |
| APPL NO | 17/617706 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) G01N 33/56905 (20130101) Original (OR) Class G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220236358 | Trzasko et al. |
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| FUNDED BY |
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| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joshua D. Trzasko (Rochester, Minnesota); Matthew A. Bernstein (Rochester, Minnesota); Uten Yarach (Rochester, Minnesota) |
| ABSTRACT | Images are reconstructed from k-space data using a model-based image reconstruction that prospectively and simultaneously accounts for multiple non-idealities in accelerated single-shot-EPI acquisitions. In some implementations, nonlinear regularization (e.g., sparsity regularization) is also incorporated to mitigate noise amplification. The reconstructed images have reduced distortions and noise amplification effects relative to those images that are processed using conventional post-reconstruction techniques to correct for non-idealities. |
| FILED | Thursday, April 23, 2020 |
| APPL NO | 17/606645 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/4818 (20130101) G01R 33/5608 (20130101) G01R 33/5616 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220237785 | MITCHELL |
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| FUNDED BY |
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| APPLICANT(S) | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph Ross MITCHELL (Tampa, Florida) |
| ABSTRACT | The first objective comparison of automated and human segmentation of magnetic resonance images, or MRI, using a blinded controlled assessment study. Computers connected over a network divide duties including computerized segmenting of the images, manual segmenting of the images, comparison of the computer segmented images and the manually segmented images, and scoring of the images for accuracy. The scores are evaluated to update configuration parameters of a neural network. |
| FILED | Tuesday, May 26, 2020 |
| APPL NO | 17/613642 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 2207/10088 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30016 (20130101) G06T 2207/30096 (20130101) Image or Video Recognition or Understanding G06V 10/26 (20220101) G06V 10/82 (20220101) G06V 2201/03 (20220101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220237801 | KAUFMAN et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ARIE KAUFMAN (Plainview, New York); KONSTANTIN DMITRIEV (Port Jefferson, New York) |
| ABSTRACT | The exemplary system, method, and computer-accessible medium for generating a multiclass image segmentation model(s) can include receiving multiple single-class image datasets, receiving a target mask for each of the single-class image datasets, receiving a condition of an object associated with each of the single-class image datasets, and generating the multiclass image segmentation model(s) based on the single-class image datasets, the target masks, and the identification of the target objects. The single-class image datasets can include computer tomography images of abdominal organs. The single-class image datasets can be non-overlapping single-class image datasets. The single-class image datasets can include medical imaging datasets or cityscape datasets. The condition can include (i) an identification of a target object associated with each image in each single-class image dataset, (ii) a classification of each image associated with each single-class image dataset or (iii) an identifiable detail regarding each image in each single-class image datasets. |
| FILED | Thursday, May 28, 2020 |
| APPL NO | 17/614702 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/11 (20170101) Original (OR) Class G06T 2207/10081 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220237810 | ANDERSON et al. |
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| FUNDED BY |
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| APPLICANT(S) | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander ANDERSON (Tampa, Florida); Mark ROBERTSON-TESSI (Lutz, Florida); Chandler GATENBEE (Tampa, Florida) |
| ABSTRACT | Systems and methods for slide image alignment are described herein. An example method includes receiving a plurality of slide images, detecting a plurality of features contained in the slide images, and comparing a plurality of pairs of the slide images. The comparison uses the detected features. The method also includes creating a distance matrix that reflects a respective difference between each of the pairs of the slide images, creating a graph by connecting each of the slide images to its most similar slide image, and detecting a plurality of graph components. Each of the graph components includes one or more of the slide images. The method further includes aligning the slide images within each of the graph components, and aligning the graph components to form a composite image. |
| FILED | Monday, May 11, 2020 |
| APPL NO | 17/609922 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 3/0068 (20130101) G06T 3/4038 (20130101) G06T 7/337 (20170101) Original (OR) Class G06T 2207/30024 (20130101) Image or Video Recognition or Understanding G06V 10/24 (20220101) G06V 10/751 (20220101) G06V 10/761 (20220101) G06V 10/7625 (20220101) G06V 20/695 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220237864 | Mirramezani et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Seyed Mehran Mirramezani (Albany, California); Shawn Shadden (Albany, California) |
| ABSTRACT | A computer-implemented method can include generating centerlines of a patient's cardiovascular network, determining geometric features of the cardiovascular network based on the centerlines and a three-dimensional (3D) computer model of the cardiovascular network, constructing a lumped parameter network (LPN) of resistors corresponding to the cardiovascular network, and solving a system of equations corresponding to flow and pressure for the LPN model. |
| FILED | Friday, June 26, 2020 |
| APPL NO | 17/621645 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 34/10 (20160201) A61B 2034/105 (20160201) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 7/60 (20130101) G06T 17/00 (20130101) Original (OR) Class G06T 2207/30048 (20130101) G06T 2207/30104 (20130101) G06T 2210/24 (20130101) G06T 2210/41 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220237930 | RANDO et al. |
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| FUNDED BY |
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| APPLICANT(S) | FOUNTAIN THERAPEUTICS, INC. (San Francisco, California); THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas A. RANDO (Stanford, California); Joe RODGERS (San Francisco, California); Hiu Tung CHEUNG (San Francisco, California); Kirsten OBERNIER (San Francisco, California); Fabian ORTEGA (San Francisco, California); Ryan ZARCONE (San Francisco, California) |
| ABSTRACT | The present disclosure provides methods and systems for cell age classification. The method for cell age classification may process images of cells to generate enhanced cell images. The enhanced image of the cell may focus on cell age-dependent phenotypes that may be characteristic of the biological age of the cell. To further improve cell age classification, enhanced cell images may be concatenated and provided to a machine learning-based classifier as an image array and as a single data point. The machine learning-based classifier may use the concatenated enhanced cell images to more accurately determine the age group of the cells. Furthermore, the effects of drug candidates on the biological age of the cells can be determined by contacting the cells of a known chronological age with one or more drug candidates and obtaining images of the cells at a time after the cells have been contacted with the drug candidates. |
| FILED | Thursday, February 17, 2022 |
| APPL NO | 17/674342 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/0012 (20130101) Image or Video Recognition or Understanding G06V 10/764 (20220101) G06V 20/698 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220238180 | Yandell et al. |
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| FUNDED BY |
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| APPLICANT(S) | Fabric Genomics, Inc. (Oakland, California); University of Utah (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark Yandell (Salt Lake City, Utah); Marc Singleton (Salt Lake City, Utah); Martin Reese (Oakland, California); Karen Eilbeck (Salt Lake City, Utah) |
| ABSTRACT | The present disclosure provides methods and systems for prioritizing phenotype-causing genomic variants. The methods include using variant prioritization analyses and in combination with biomedical ontologies using a sophisticated re-ranking methodology to re-rank these variants based on phenotype information. The methods can be useful in any genomics study and diagnostics; for example, rare and common disease gene discovery, tumor growth mutation detection, drug responder studies, metabolic studies, personalized medicine, agricultural analysis, and centennial analysis. |
| FILED | Friday, November 05, 2021 |
| APPL NO | 17/520037 |
| CURRENT CPC | Electric Digital Data Processing G06F 7/02 (20130101) G06F 40/169 (20200101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) Original (OR) Class G16B 20/20 (20190201) G16B 20/30 (20190201) G16B 20/40 (20190201) G16B 30/00 (20190201) G16B 30/10 (20190201) G16B 40/00 (20190201) G16B 45/00 (20190201) G16B 50/00 (20190201) G16B 50/10 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220238182 | Shen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Max Walt Shen (Cambridge, Massachusetts); Jonathan Yee-Ting Flsu (Cambridge, Massachusetts); Mandana Arbab (Cambridge, Massachusetts); David K. Gifford (Cambridge, Massachusetts); David R. Liu (Cambridge, Massachusetts); Richard Irving Sherwood (Cambridge, Massachusetts) |
| ABSTRACT | The specification provides methods for introducing a desired genetic change in a nucleotide sequence using a double-strand break (DSB)-inducing genome editing system, the method comprising: identifying one or more available cut sites in a nucleotide sequence; analyzing the nucleotide sequence and available cut sites with a computational model to identify the optimal cut site for introducing the desired genetic change into the nucleotide sequence; and contacting the nucleotide sequence with a DSB-inducing genome editing system, thereby introducing the desired genetic change in the nucleotide sequence at the cut site. |
| FILED | Saturday, December 15, 2018 |
| APPL NO | 16/772747 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) A61K 38/465 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/1089 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/30 (20190201) Original (OR) Class G16B 40/20 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220238786 | Fischer et al. |
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| FUNDED BY |
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| APPLICANT(S) | Gregory Scott Fischer (Boston, Massachusetts); Paulo Alberto Carvalho (Worcester, Massachusetts); Zhanyue Zhao (Shrewsbury, Massachusetts); Christopher Julius Nycz (Wallkill, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregory Scott Fischer (Boston, Massachusetts); Paulo Alberto Carvalho (Worcester, Massachusetts); Zhanyue Zhao (Shrewsbury, Massachusetts); Christopher Julius Nycz (Wallkill, New York) |
| ABSTRACT | An actuator (100) powered by photonic energy comprises a rotor including a material (101) which deforms from a first underformed state when exposed to electromagnetic radiation to a second deformed state and begins to return to the first state when the electromagnetic radiation is removed. A stationary element (102) is affixed to the rotor. A moving element (105) engaging the stator at least when the rotor is in the second deformed state. Deformation of the deformable material in response to applied electromagnetic radiation is transmitted by the stator to the moving element by friction between the stationary element and the moving element for causing motion of the moving element. |
| FILED | Wednesday, June 03, 2020 |
| APPL NO | 17/616136 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 41/083 (20130101) Original (OR) Class H01L 41/1876 (20130101) Electric Machines Not Otherwise Provided for H02N 2/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220239615 | Hsu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Salk Institute for Biological Studies (La Jolla, California) |
| ASSIGNEE(S) | Salk Institute for Biological Studies (La Jolla, California) |
| INVENTOR(S) | Patrick D. Hsu (San Francisco, California); Silvana Konermann (Menlo Park, California) |
| ABSTRACT | Provided herein are CRISPR/Cas methods and compositions for targeting RNA molecules, which can be used to detect, edit, or modify a target RNA. |
| FILED | Friday, April 01, 2022 |
| APPL NO | 17/711924 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/85 (20130101) C12N 15/102 (20130101) C12N 15/113 (20130101) C12N 15/8201 (20130101) C12N 15/8213 (20130101) C12N 2310/16 (20130101) C12N 2310/20 (20170501) C12N 2310/3519 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/08 (20130101) H04L 9/30 (20130101) H04L 45/745 (20130101) H04L 51/08 (20130101) H04L 51/12 (20130101) Original (OR) Class H04L 51/14 (20130101) H04L 51/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20220233563 | Crabtree et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Gerald R. Crabtree (Woodside, California); Christina Curtis (Stanford, California); Jose A. Seoane Fernandez (Stanford, California); Jacob G. Kirkland (East Palo Alto, California) |
| ABSTRACT | Methods of treatment based on a neoplasm's responsiveness to anthracycline are provided. Chromatin accessibility or expression levels of chromatin regulatory genes are used in some instances to determine whether a neoplasm will respond to anthracycline treatment. Anthracyclines are utilized to treat various individuals' neoplasms and cancers, as determined by their anthracycline responsiveness. |
| FILED | Monday, March 30, 2020 |
| APPL NO | 17/600004 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/136 (20130101) A61K 31/138 (20130101) A61K 31/337 (20130101) A61K 31/513 (20130101) A61K 31/519 (20130101) A61K 31/565 (20130101) A61K 31/675 (20130101) A61K 31/704 (20130101) Original (OR) Class A61K 31/4745 (20130101) A61K 31/5545 (20170801) A61K 31/7068 (20130101) A61K 33/243 (20190101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220233576 | BOEHNKE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Natalie BOEHNKE (Cambridge, Massachusetts); Joelle Payne STRAEHLA (Cambridge, Massachusetts); Angela KOEHLER (Cambridge, Massachusetts); Paula HAMMOND (Cambridge, Massachusetts) |
| ABSTRACT | SLC46A3 has been identified as a lipid-based nanoparticle-specific biomarker predictive of nanoparticle-cancer cell affinity. SLC46A3 has a strong inverse association with lipid-based nanoparticle uptake across multiple nanoparticle formulations. Tissues with decreased expression levels of SLC46A3 have a greater uptake of lipid-based nanoparticles. The inverse relationship of SLC46A3 expression in tumor tissue and affinity for lipid-based nanoparticles has therapeutic and diagnostic implications, including cancer therapy and diagnosis, and identification of patients most likely to benefit from a lipid-based nanotherapeutic for improved stratification in clinical trials. |
| FILED | Monday, January 24, 2022 |
| APPL NO | 17/582594 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1271 (20130101) A61K 9/1617 (20130101) A61K 9/1635 (20130101) A61K 9/1647 (20130101) A61K 31/7105 (20130101) Original (OR) Class A61K 38/465 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1135 (20130101) C12N 2320/34 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220233670 | Spencer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BAYLOR COLLEGE OF MEDICINE (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Spencer (Frisco, Texas); Brent Hanks (Durham, North Carolina); Kevin Slawin (Houston, Texas) |
| ABSTRACT | The present invention is directed to a composition and method which to treat diseases and to enhance a regulated immune response. More particularly, the present invention is drawn to compositions that are based on dendritic cells modified to express an inducible form of a co-stimulatory polypeptide. |
| FILED | Friday, September 17, 2021 |
| APPL NO | 17/478488 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/15 (20130101) A61K 38/177 (20130101) A61K 38/1774 (20130101) A61K 39/02 (20130101) Original (OR) Class A61K 39/0011 (20130101) A61K 39/12 (20130101) A61K 2039/53 (20130101) A61K 2039/5154 (20130101) A61K 2039/5156 (20130101) A61K 2039/55516 (20130101) Peptides C07K 14/70578 (20130101) C07K 2319/033 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/10 (20130101) C12N 5/16 (20130101) C12N 9/90 (20130101) C12N 9/485 (20130101) C12N 2710/10043 (20130101) Enzymes C12Y 502/01008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220233703 | Legler et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Patricia M. Legler (Derwood, Maryland); Arthur M. Friedlander (Frederick, Maryland); Jaimee R. Compton (Washington, District of Columbia) |
| ABSTRACT | A pegylated, circularly permuted construct of the CapD enzyme (a gamma glutamyl transferase enzyme acting as a hydrolase specific to poly-γ-D-glutamic acid) is used to treat anthrax and other bacterial infections, including but not limited to infection with strains that are resistant to available antibiotics. |
| FILED | Tuesday, January 18, 2022 |
| APPL NO | 17/577893 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/45 (20130101) A61K 47/60 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220233865 | KAHANA et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Michael KAHANA (Merion Station, Pennsylvania); Daniel S. RIZZUTO (Philadelphia, Pennsylvania) |
| ABSTRACT | A method for delivering electrical stimulation to alter a cognitive state of a user, the method comprising: monitoring a brain signal from the user via one or more intracranial electrodes implanted in the brain of the user while the user is presented with a stimulus; comparing the brain signal to a testing phase biomarker, wherein the testing phase biomarker is derived from a cognitive test performed on a contributor during a testing phase; delivering electrical stimulation to a brain of the user based on the comparing step to steer the brain of the user towards a high performance cognitive state. |
| FILED | Friday, April 08, 2022 |
| APPL NO | 17/717024 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/377 (20210101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0531 (20130101) A61N 1/0534 (20130101) A61N 1/36064 (20130101) A61N 1/36067 (20130101) A61N 1/36082 (20130101) Original (OR) Class A61N 1/36135 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220234103 | Wei et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wei David Wei (Gainesville, Florida); Yueming Zhai (Gainesville, Florida) |
| ABSTRACT | In one aspect, the present disclosure pertains to methods of making various noble metal nanoprisms, e.g., gold nanoprisms. In various aspects, the methods can comprise incubating, under dark conditions, a growth solution comprising: (a) a plurality of gold seed structures; (b) a gold precursor, and (c) a photocatalytic intermediary, such that during the incubating step multiply-twinned gold seed structures in the growth solution are preferentially enlarged. The disclosed methods can comprise separating the multiply-twinned gold seed structures from the growth solution based upon the size of the gold seed structures to produce an enriched growth solution. In some aspects, the methods comprise irradiating the enriched growth solution to produce the gold nanoprisms. In some aspects, the disclosed nanoprisms comprise silver. |
| FILED | Monday, March 14, 2022 |
| APPL NO | 17/694162 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/054 (20220101) B22F 9/24 (20130101) Original (OR) Class Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Production and Refining of Metals; Pretreatment of Raw Materials C22B 11/04 (20130101) Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 7/14 (20130101) C30B 29/66 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220234310 | Carlson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Bell Textron Inc. (Fort Worth, Texas) |
| ASSIGNEE(S) | Bell Textron Inc. (Fort Worth, Texas) |
| INVENTOR(S) | David G. Carlson (North Richland Hills, Texas); Paul K. Oldroyd (Azle, Texas); George R. Decker (Loveland, Colorado); Doug K. Wolfe (Denton, Texas) |
| ABSTRACT | A method of preparing a composite article including providing a first bias assembly with a first bias roll; providing a first non-bias assembly with a first non-bias roll; positioning the first bias assembly to a dispensing position; dispensing a bias ply from the first bias roll along a bias path on a mold; cutting the bias ply; positioning the first non-bias assembly to a dispensing position; dispensing a non-bias ply from the first non-bias roll; and cutting the non-bias ply; wherein the bias path and the non-bias path are substantially parallel. |
| FILED | Friday, October 22, 2021 |
| APPL NO | 17/508299 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 70/34 (20130101) B29C 70/38 (20130101) Original (OR) Class Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2031/3082 (20130101) Ground or Aircraft-carrier-deck Installations Specially Adapted for Use in Connection With Aircraft; Designing, Manufacturing, Assembling, Cleaning, Maintaining or Repairing Aircraft, Not Otherwise Provided For; Handling, Transporting, Testing or Inspecting Aircraft Components, Not Otherwise Provided for B64F 5/10 (20170101) Handling Thin or Filamentary Material, e.g Sheets, Webs, Cables B65H 16/005 (20130101) B65H 16/021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220234893 | Dietz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TDA Research, Inc (Wheat Ridge, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven Dean Dietz (Denver, Colorado); Jeremy Noce (Lakewood, Colorado) |
| ABSTRACT | An activated carbon-coated carbon black material having a nitrogen BET surface area of about 850 to 1800 m2/g, a packing density of at least 0.8 g/cc as determined at a compressive force of 500 kgf/cm2 on dry carbon powder, an electrical conductivity of a least 10 S/cm at a compressive force of 500 kgf/cm2 on dry carbon powder and electrodes and batteries comprising the carbon material. Methods for preparing such carbon materials from sugar, dextrose, oils and carbon black are described. The material is comprised of carbon black particles coated with a porous activated carbon shell. |
| FILED | Monday, May 04, 2020 |
| APPL NO | 17/609737 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/05 (20170801) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2006/10 (20130101) C01P 2006/12 (20130101) C01P 2006/40 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/583 (20130101) H01M 10/052 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220235075 | Bardon et al. |
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| FUNDED BY |
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| APPLICANT(S) | Akita Innovations LLC (Billerica, Massachusetts) |
| ASSIGNEE(S) | Akita Innovations LLC (Billerica, Massachusetts) |
| INVENTOR(S) | Kevin M. Bardon (Holbrook, Massachusetts); Richard A. Minns (Arlington, Massachusetts); Scott D. Selfridge (Hudson, New Hampshire); Larry Takiff (Woburn, Massachusetts); Timothy Adams (Howell, New Jersey) |
| ABSTRACT | Voltage sensitive dyes comprising boron and related compositions and methods are provided. In some embodiments, a voltage sensitive dye comprises an electron acceptor comprising boron. The electron acceptor may be attached (e.g., covalently) to at least one electron donating group and at least one polar group. For instance, the electron acceptor may comprise optionally substituted boron dipyrromethene (e.g., optionally substituted 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene). The point of attachment and chemical nature of the electron donating group(s) and polar group(s) may be selected to impart beneficial properties to the voltage sensitive dye. For instance, the voltage sensitive dye may have an extended difference in the dipole moment between the ground and electronic states due at least in part to the position of the electron donating group(s). The voltage sensitive dyes, described herein, may have high specificity, high signal to noise ratio, fast responsivity, high voltage sensitivity, high photostability, and/or high brightness. |
| FILED | Thursday, March 31, 2022 |
| APPL NO | 17/710911 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0071 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 49/006 (20130101) A61K 49/0017 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/022 (20130101) Original (OR) Class Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) C09K 2211/1029 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220235353 | Hochrein et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lisa Hochrein (Pasadena, California); Heyun Li (Pasadena, California); Evan Mun (Pasadena, California); Paul W. Rothemund (Pasadena, California); Niles A. Pierce (Pasadena, California) |
| ABSTRACT | Nucleic acids (DNA and RNA) provide a versatile platform for engineering synthetic biology in a variety of technology areas including medicine, science, agriculture, and energy. In many settings, degradation of nucleic acid molecules poses a significant engineering challenge as the molecules do not function if they have been degraded. In some embodiments, nucleic acid protective elements (PELs) are used to protect chemically synthesized or expressed nucleic acid molecules from degradation. PELs may be derived from all or part of a viral xrRNA sequence and/or structural motif, PELs may include rationally designed sequences and/or structural motifs, PELs may be engineered using directed evolution, and in some embodiments, PELs comprise a mixture of biologically derived, rationally designed sequence and/or structural motifs, and/or sequences and/or structural motifs that are engineered by directed evolution. In some embodiments, PELs significantly enhance the performance of nucleic acid synthetic biology, protecting nucleic acid regulatory and/or structural elements from degradation to increase regulatory dynamic range, fractional dynamic range, fold-change, and/or other performance metrics. In some embodiments, PELs that reduce nucleic acid degradation provide a platform technology for enhancing the performance of synthetic biology, with applications including therapeutics, diagnostics, biological research tools, vaccines, crop protection, molecular manufacturing, sustainable energy production, and other areas involving nucleic acids. |
| FILED | Tuesday, January 25, 2022 |
| APPL NO | 17/584271 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/102 (20130101) C12N 15/111 (20130101) Original (OR) Class C12N 15/113 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220235389 | Jewett et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | Northwestern University (Evanston, Illinois) |
| INVENTOR(S) | Michael Christopher Jewett (Evanston, Illinois); Weston K. Kightlinger (Evanston, Illinois); Liang Lin (Evanston, Illinois); Milan Mrksich (Hinsdale, Illinois) |
| ABSTRACT | Disclosed are components, systems, and methods for glycoprotein or recombinant glycoprotein protein synthesis in vitro and in vivo. In particular, the present invention relates to components, systems, and methods for identifying amino acid glycosylation tag motifs for N-glycosyltransferases and the use of the identified amino acid glycosylation tag motifs in methods for preparing glycoproteins and recombinant glycoproteins in vitro and in vivo. |
| FILED | Wednesday, August 15, 2018 |
| APPL NO | 16/639500 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1051 (20130101) C12N 15/1044 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/005 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/48 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6851 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220235488 | KOLIS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CLEMSON UNIVERSITY (Clemson, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | JOSEPH W. KOLIS (CLEMSON, South Carolina); RYLAN J. TERRY (CLEMSON, South Carolina); COLIN D. MCMILLEN (CLEMSON, South Carolina) |
| ABSTRACT | Hydrothermal methods for the synthesis of bulk crystals of alkaline earth metal stannates are described. Methods can be utilized for growth of large, single crystals of alkaline earth metal stannates including fully cubic BaSnO3 and SrSnO3. |
| FILED | Wednesday, January 26, 2022 |
| APPL NO | 17/584807 |
| CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 7/04 (20130101) C30B 7/005 (20130101) C30B 29/22 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220235662 | Hagan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Allen Hagan (Reading, Massachusetts); Jason Francis Pepi (Augusta, Maine); Kevin Robert Shannon (Boston, Massachusetts) |
| ABSTRACT | Methods, apparatus, and systems for trapped rotatable weights to improve rotor balance are disclosed. An example apparatus includes a lock nut; a rotor assembly; a channel defined by the lock nut and the rotor assembly, the channel wrapped circumferentially around a geometric center of the rotor assembly; and a weight trapped within the channel. |
| FILED | Thursday, January 28, 2021 |
| APPL NO | 17/161490 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/027 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2240/24 (20130101) F05D 2240/30 (20130101) F05D 2260/15 (20130101) F05D 2260/34 (20130101) Springs; Shock-absorbers; Means for Damping Vibration F16F 15/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220235727 | Wegener et al. |
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| FUNDED BY |
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| APPLICANT(S) | Physical Sciences, Inc. (Andover, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey L. Wegener (Nashua, New Hampshire); Christopher T. Farrell (Medford, Massachusetts) |
| ABSTRACT | A rotating detonation engine includes an outer body with an opening therethrough having an interior wall and an inner body received in the outer body opening and with an outer wall tapering in the flow direction of the engine and spaced from the outer body opening interior wall defining a non-cylindrical improved efficiency detonation channel between the inner body outer wall and outer body opening interior wall. |
| FILED | Monday, January 24, 2022 |
| APPL NO | 17/582408 |
| CURRENT CPC | Jet-propulsion Plants F02K 9/66 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220235823 | Davis et al. |
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| FUNDED BY |
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| APPLICANT(S) | RAYTHEON TECHNOLOGIES CORPORATION (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Todd A. Davis (Tolland, Connecticut); Dale C. Humphries (Southington, Connecticut) |
| ABSTRACT | A gas turbine engine according to an exemplary aspect of the present disclosure includes, among other things, a bearing compartment, a seal runner, a seal configured to cooperate with the seal runner to seal the bearing compartment, and a catcher in contact with the seal runner to minimize deflection of the seal runner. A method is also disclosed. |
| FILED | Monday, December 20, 2021 |
| APPL NO | 17/555567 |
| CURRENT CPC | Shafts; Flexible Shafts; Elements or Crankshaft Mechanisms; Rotary Bodies Other Than Gearing Elements; Bearings F16C 33/76 (20130101) Original (OR) Class F16C 2360/23 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220235931 | Fokema et al. |
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| FUNDED BY |
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| APPLICANT(S) | Aspen Products Group, Inc. (Marlborough, Massachusetts) |
| ASSIGNEE(S) | Aspen Products Group, Inc. (Marlborough, Massachusetts) |
| INVENTOR(S) | Mark D. Fokema (Northborough, Massachusetts); Decio H. Coutinho (Marlborough, Massachusetts); Craig D. Thompson (Sudbury, Massachusetts); Sai C. Yelishala (Westborough, Massachusetts) |
| ABSTRACT | A liquid-hydrocarbon fuel is used to produce thermal energy by introducing the liquid-hydrocarbon fuel and air to a vaporizer. The liquid-hydrocarbon fuel is vaporized in the vaporizer to produce hydrocarbon-fuel vapor, and the hydrocarbon-fuel vapor and air are blended to form a hydrocarbon-fuel-vapor-and-air mixture. Then, hydrocarbon-fuel-vapor-and-air mixture is introduced to a catalytic combustor including a catalyst, wherein the catalyst promotes oxidation of the hydrocarbon-fuel vapor to form a carbon-dioxide- and water-vapor-containing exhaust and to generate thermal energy. The carbon-dioxide- and water-vapor-containing exhaust and air is then introduced to a recuperator, wherein the recuperator transfers thermal energy from the carbon-dioxide- and water-vapor-containing exhaust to the air to produce heated air. |
| FILED | Tuesday, November 16, 2021 |
| APPL NO | 17/527335 |
| CURRENT CPC | Burners F23D 11/443 (20130101) Original (OR) Class F23D 2900/00001 (20130101) F23D 2900/3102 (20210501) Supplying Air or Non-combustible Liquids or Gases to Combustion Apparatus in General; Valves or Dampers Specially Adapted for Controlling Air Supply or Draught in Combustion Apparatus; Inducing Draught in Combustion Apparatus; Tops for Chimneys or Ventilating Shafts; Terminals for Flues F23L 15/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220236041 | Bugge et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John F. Bugge (Tucson, Arizona); Byron T. Edgar (Tucson, Arizona) |
| ABSTRACT | A projectile and method of deploying a projectile includes a wing deployment system for deploying a wing of a projectile. The wing deployment system includes a stored energy release mechanism that is activated to generate an initial range of motion of the wing and a panel arranged on the wing and configured to cause an angular acceleration of the wing during the initial range of motion of the wing. |
| FILED | Tuesday, January 26, 2021 |
| APPL NO | 17/158869 |
| CURRENT CPC | Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 10/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220236113 | Goldstein et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Jordan Goldstein (Cambridge, Massachusetts); Christopher Louis Panuski (Somerville, Massachusetts); Dirk Robert ENGLUND (Brookline, Massachusetts) |
| ABSTRACT | Optical microcavity resonance measurements can have readout noise matching the fundamental limit set by thermal fluctuations in the cavity. Small-heat-capacity, wavelength-scale microcavities can be used as bolometers that bypass the limitations of other bolometer technologies. The microcavities can be implemented as photonic crystal cavities or micro-disks that are thermally coupled to strong mid-IR or LWIR absorbers, such as pyrolytic carbon columns. Each microcavity and the associated absorber(s) rest on hollow pillars that extend from a substrate and thermally isolate the cavity and the absorber(s) from the rest of the bolometer. This ensures that thermal transfer to the absorbers is predominantly from radiation as opposed to from conduction. As the absorbers absorb thermal radiation, they shift the resonance wavelength of the cavity. The cavity transduces this thermal change into an optical signal by reflecting or scattering more (or less) near-infrared (NIR) probe light as a function of the resonance wavelength shift. |
| FILED | Monday, May 31, 2021 |
| APPL NO | 17/335017 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 5/34 (20130101) G01J 5/0818 (20130101) G01J 5/0853 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220236177 | Terracciano et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anthony C. Terracciano (Orlando, Florida); Christopher Arose (Orlando, Florida); Subith Vasu (Orlando, Florida) |
| ABSTRACT | A device configured to inhibit the reflectance of electromagnetic radiation in the terahertz (THz) frequency range. This characterization is a combination of material and geometric parameters which are unique and tunable enabling resonating frequencies (spectral selectivity) in the THz range (0.1-25) with narrow channel widths (FWHM) controllable by the thickness and electrical properties of the crystalline material. This device may be integrated with broadband sources or co-integrated with other analytical detection methods (e.g., chromatography, Fourier Transform Reflectance Spectroscopy). |
| FILED | Wednesday, November 24, 2021 |
| APPL NO | 17/456493 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 11/0625 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/3581 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220236492 | Correa et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (Orlando, Florida) |
| ASSIGNEE(S) | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (Orlando, Florida) |
| INVENTOR(S) | Rodrigo Amezcua Correa (Orlando, Florida); Juan Carlos Alvarado Zacarias (Orlando, Florida); Jose Enrique Antonio Lopez (Orlando, Florida) |
| ABSTRACT | A multicore fiber-to-single core fiber adapting device, also referred a fan-in/fan-out (FIFO) device. More specifically, an optical fiber system comprising a multicore fiber, a tapered glass device that it is configured to connect a multicore fiber to a multiple single core fiber, and/or single mode fibers, advantageously having one or more protective layers to protect the tapered device. Associated methods of manufacture. |
| FILED | Thursday, January 20, 2022 |
| APPL NO | 17/648473 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/02042 (20130101) G02B 6/3825 (20130101) Original (OR) Class G02B 6/3867 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220236641 | Mirkin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chad A. Mirkin (Wilmette, Illinois); Rustin Golnabi (Evanston, Illinois); Eun Bi Oh (Evanston, Illinois); David Alan (Evanston, Illinois) |
| ABSTRACT | Disclosed herein is a massively parallel patterning tool for the deposition of single metals or metal alloys with size and composition control. Methods of the disclosure use a hydrogel array of pyramidal pen tips as a medium for localized electrodeposition, in conjunction with a scanning probe lithography platform and a three-electrode cell. This versatile technique can be used for high-throughput 3D printing, biomolecule patterning, or screening of catalyst nanoparticles or thin films. |
| FILED | Wednesday, January 26, 2022 |
| APPL NO | 17/585316 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 33/38 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/0002 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220236761 | MONROE et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher MONROE (Ellicott City, Maryland); Jiehang ZHANG (College Park, Maryland); David WONG-CAMPOS (Hyattsville, Maryland); Antonios KYPRIANIDIS (Takoma, Maryland); Patrick Michael BECKER (College Park, Maryland) |
| ABSTRACT | The disclosure describes an adaptive and optimal imaging of individual quantum emitters within a lattice or optical field of view for quantum computing. Advanced image processing techniques are described to identify individual optically active quantum bits (qubits) with an imager. Images of individual and optically-resolved quantum emitters fluorescing as a lattice are decomposed and recognized based on fluorescence. Expected spatial distributions of the quantum emitters guides the processing, which uses adaptive fitting of peak distribution functions to determine the number of quantum emitters in real time. These techniques can be used for the loading process, where atoms or ions enter the trap one-by-one, for the identification of solid-state emitters, and for internal state-detection of the quantum emitters, where each emitter can be fluorescent or dark depending on its internal state. This latter application is relevant to efficient and fast detection of optically active qubits in quantum simulations and quantum computing. |
| FILED | Thursday, October 28, 2021 |
| APPL NO | 17/513496 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) B82Y 40/00 (20130101) Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 1/42 (20130101) G01J 2001/4247 (20130101) Optical Computing Devices; G06E 3/005 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/66977 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220237020 | Brewer |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tony Brewer (Plano, Texas) |
| ABSTRACT | Devices and techniques for self-scheduling threads in a programmable atomic unit are described herein. When it is determined that an instruction will not complete within a threshold prior to insertion into a pipeline of the processor, a thread identifier (ID) can be passed with the instruction. Here, the thread ID corresponds to a thread of the instruction. When a response to completion of the instruction is received that includes the thread ID, the thread is rescheduled using the thread ID in the response. |
| FILED | Tuesday, October 20, 2020 |
| APPL NO | 17/075399 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/48 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220237290 | VILLEGAS |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CARLOS A. VILLEGAS (Redondo Beach, California) |
| ASSIGNEE(S) | NORTHROP GRUMMAN SYSTEMS CORPORATION (FALLS CHURCH, Virginia) |
| INVENTOR(S) | CARLOS A. VILLEGAS (Redondo Beach, California) |
| ABSTRACT | In some examples, an analyzer manager configured to select one of a program code analyzer, a static data analyzer, and an unused memory location analyzer for malware detection within memory of a system. The program code analyzer can be executed to evaluate instruction data for executing a computer program at a first set of memory locations within the memory for malware in response to being selected by the analyzer manager. The static data analyzer can be executed to evaluate static data for use by the computer program at a second set of memory locations within the memory for the malware in response to being selected by the analyzer manager. The unused memory location analyzer can be executed to evaluate null data indicative of unused memory locations at a third set of memory locations within the memory for the malware in response to being selected by the analyzer manager. |
| FILED | Thursday, January 28, 2021 |
| APPL NO | 17/160701 |
| CURRENT CPC | Electric Digital Data Processing G06F 12/14 (20130101) G06F 21/64 (20130101) G06F 21/79 (20130101) G06F 21/563 (20130101) Original (OR) Class G06F 2212/1052 (20130101) G06F 2221/034 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220237347 | Hughes et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tyler William Hughes (San Diego, California); Ian A.D. Williamson (Mountain View, California); Momchil Minkov (San Mateo, California); Shanhui Fan (Stanford, California) |
| ABSTRACT | A method is disclosed for designing an analog computer that implements a trained recurrent neural network. A computer simulates a wave-based physical system including a wave propagation domain, a boundary layer that approximates a boundary condition, a source of waves, probes for measuring properties of propagated waves, a material within a central region of the wave propagation domain. The simulation also includes a discretized numerical model of a differential equation describing dynamics of wave propagation in the physical system. The simulation is trained with sequential training data by inputing samples of the training data at the source in batches, computing for each batch measured properties of propagated waves at the probes, evaluating for each batch a loss function between the measured properties of propagated waves at the probes and correct classification, and minimizing the loss function with respect to physical characteristics of the material within a central region of the simulation domain using gradient-based optimization. |
| FILED | Sunday, April 19, 2020 |
| APPL NO | 16/852511 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/27 (20200101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/0445 (20130101) G06N 3/0635 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220238182 | Shen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Max Walt Shen (Cambridge, Massachusetts); Jonathan Yee-Ting Flsu (Cambridge, Massachusetts); Mandana Arbab (Cambridge, Massachusetts); David K. Gifford (Cambridge, Massachusetts); David R. Liu (Cambridge, Massachusetts); Richard Irving Sherwood (Cambridge, Massachusetts) |
| ABSTRACT | The specification provides methods for introducing a desired genetic change in a nucleotide sequence using a double-strand break (DSB)-inducing genome editing system, the method comprising: identifying one or more available cut sites in a nucleotide sequence; analyzing the nucleotide sequence and available cut sites with a computational model to identify the optimal cut site for introducing the desired genetic change into the nucleotide sequence; and contacting the nucleotide sequence with a DSB-inducing genome editing system, thereby introducing the desired genetic change in the nucleotide sequence at the cut site. |
| FILED | Saturday, December 15, 2018 |
| APPL NO | 16/772747 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) A61K 38/465 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/1089 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/30 (20190201) Original (OR) Class G16B 40/20 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220238245 | Endres et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Manuel Endres (Pasadena, California); Alexandre Cooper-Roy (Downey, California); Jacob P. Covey (Pasadena, California); Ivaylo S. Madjarov (Pasadena, California); Adam L. Shaw (Pasadena, California); Vladimir Schkolnik (Pasadena, California); Jason R. Williams (Castaic, California); Joonhee Choi (Pasadena, California) |
| ABSTRACT | An apparatus useful for creating and measuring states of an entangled system, comprising a pair of interacting multi-level systems, each of systems comprising a state |g>; a state |r>, and state |r*>. One or more first electromagnetic fields excite a first transition between the ground state |g> and the state |r> to create an entangled system. One or more second electromagnetic fields are tuned between the state |r> and the intermediate state |r*> so that any population of the systems in |r*> are dark to a subsequent detection of a population in the systems in |g>, providing a means to distinguish the entangled system in the state |g> and the entangled system in the state |r>. In one or more examples, the systems comprise neutral Rydberg atoms. |
| FILED | Wednesday, February 10, 2021 |
| APPL NO | 17/172885 |
| CURRENT CPC | Techniques for Handling Particles or Ionising Radiation Not Otherwise Provided For; Irradiation Devices; Gamma Ray or X-ray Microscopes G21K 1/003 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220238742 | Hart et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | John Hart (Albuquerque, New Mexico); Daniel Derkacs (Albuquerque, New Mexico); Zachary Bittner (Albuquerque, New Mexico); Andrew Colin Espenlaub (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Hart (Albuquerque, New Mexico); Daniel Derkacs (Albuquerque, New Mexico); Zachary Bittner (Albuquerque, New Mexico); Andrew Colin Espenlaub (Albuquerque, New Mexico) |
| ABSTRACT | A multijunction solar cell including an upper first solar subcell having a first band gap and positioned for receiving an incoming light beam; and a second solar subcell disposed below and adjacent to and lattice matched with said upper first solar subcell, and having a second band gap smaller than said first band gap; wherein at least one of the solar subcells has a graded band gap throughout the thickness of at least a portion of its emitter layer and base layer. |
| FILED | Tuesday, February 08, 2022 |
| APPL NO | 17/667194 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/065 (20130101) H01L 31/184 (20130101) H01L 31/0725 (20130101) Original (OR) Class H01L 31/0735 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220239309 | Yang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| INVENTOR(S) | Zhi Yang (Minneapolis, Minnesota); Anh Tuan Nguyen (Minneapolis, Minnesota); Diu Khue Luu (Minneapolis, Minnesota); Jian Xu (Minneapolis, Minnesota) |
| ABSTRACT | A digital-to-analog converter device including a set of components, each component included in the set of components including a number of unit cells, each unit cell being associated with a unit cell size indicating manufacturing specifications of the unit cell is provided by the present disclosure. The digital-to-analog converter device further includes a plurality of switches, each switch included in the plurality of switches being coupled to a component included in the set of components, and an output electrode coupled to the plurality of switches. The digital-to-analog converter device is configured to output an output signal at the output electrode. A first unit cell size associated with a first unit cell included in the set of components is different than a second unit cell size associated with a second unit cell included in the set of components. |
| FILED | Tuesday, April 05, 2022 |
| APPL NO | 17/713524 |
| CURRENT CPC | Coding; Decoding; Code Conversion in General H03M 1/007 (20130101) H03M 1/46 (20130101) Original (OR) Class H03M 1/447 (20130101) H03M 1/802 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220239384 | Hill et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cameron Hill (Goleta, California); James F. Buckwalter (Santa Barbara, California) |
| ABSTRACT | A method for switching interval modulation includes modulating an RF input data signal while generating and inserting additional pulses in transitions of the data signal. The additional pulses are structured to shift transition noise into higher order harmonics. Higher order harmonics are easily filtered. The generating is conducted in the digital domain. The additional pulses can be used to simplify the transmit chain through optical modulators and improve the signal integrity over long distances, can be applied at the output of a transmitter to filter power amplifier distortion, and can be appplied to non-linear RF over fiber for a distributed MIMO system. |
| FILED | Thursday, May 14, 2020 |
| APPL NO | 17/614063 |
| CURRENT CPC | Pulse Technique H03K 19/21 (20130101) Transmission H04B 10/25752 (20130101) H04B 15/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220239580 | Fouad et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hesham Fouad (Arlington, Virginia); Stephen Russell (Laurel, Maryland); Antonio Gilliam (Hopewell, Virginia) |
| ABSTRACT | Systems and methods are provided for addressing the complexity inherent in evaluating Service Oriented Architecture (SOA) systems by using meta-agent based adaptation in multi-agent systems. Embodiments of the present disclosure provide a multi-agent based automated evaluation capability for distributed, SOA systems that can dynamically adapt to the non-deterministic nature of such systems to enable a continuous monitoring capability for detecting and circumventing operational errors as they arise. |
| FILED | Thursday, December 02, 2021 |
| APPL NO | 17/541203 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 41/046 (20130101) H04L 43/10 (20130101) H04L 43/50 (20130101) Original (OR) Class H04L 67/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20220233077 | Gosink et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Luke J. Gosink (Richland, Washington); Sean McNeil (Richland, Washington); Juan M. Brandi-Lozano (Richland, Washington); Ryan Williams (Richland, Washington); Joseph R. Bruce (Richland, Washington); Jonathon D. McCall (Richland, Washington) |
| ABSTRACT | A wearable patient device is provided that includes one or more sensors. The one or more sensors can record one or both of ECG information or phonocardiographic information. The sensor information can be used to determine the blood pressure of a monitored individual, including on a continuous basis. Blood pressure can be determined using one or both of a determined time to empty or fill one or more heart chambers or first and second blood velocities. Vital sign information can be provided to a monitoring individual, including graphical representations of trend information. |
| FILED | Friday, April 08, 2022 |
| APPL NO | 17/716468 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0006 (20130101) A61B 5/021 (20130101) A61B 5/0024 (20130101) Original (OR) Class A61B 5/0205 (20130101) A61B 5/352 (20210101) A61B 5/681 (20130101) A61B 5/746 (20130101) A61B 2562/0219 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220234031 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhenglong Li (Shandong, China PRC); Brian H. Davison (Knoxville, Tennessee); Junyan Zhang (Knoxville, Tennessee) |
| ABSTRACT | A catalyst composition for converting an alcohol to olefins, the catalyst composition comprising the following components: (a) a support (e.g., particles) comprising silicon and oxygen; (b) at least one of copper and silver residing on and/or incorporated into said support; and (c) at least one lanthanide element residing on and/or incorporated into said support. The catalyst may also further include component (d), which is zinc. Also described herein is a method for converting an alcohol to one or more olefinic compounds (an olefin fraction) by contacting the alcohol with a catalyst at a temperature of at least 100° C. and up to 500° C. to result in direct conversion of the alcohol to an olefin fraction containing one or more olefinic compounds containing at least three carbon atoms; wherein ethylene and propylene are produced in a minor proportion of the olefin fraction, and butenes and higher olefins are produced in major proportion. |
| FILED | Wednesday, January 26, 2022 |
| APPL NO | 17/584651 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/08 (20130101) B01J 23/894 (20130101) Original (OR) Class Acyclic or Carbocyclic Compounds C07C 1/24 (20130101) C07C 2521/08 (20130101) C07C 2523/89 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220235076 | ZHU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado); Brown University Technology Ventures Office (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kai ZHU (Littleton, Colorado); Jinhui TONG (Wuhan, China PRC); Yuanyuan ZHOU (Hong Kong SAR, China Hong Kong); Nitin P. PADTURE (Providence, Rhode Island); Jue GONG (Chengdu, China PRC) |
| ABSTRACT | The present disclosure relates to a composition that includes a perovskite having a stoichiometry comprising A1-xFAxSn1-yBy(I1-zXz)3, where A is a first cation, B is a second cation, X is a halide, and 0.5≤x≤0.9, 0.5≤y≤0.9, and 0≤z≤1. In some embodiments of the present disclosure, A may include at least one of cesium, guanidinium, and/or methylammonium. In some embodiments of the present disclosure, X may include at least one of bromide and/or chloride. In some embodiments of the present disclosure, z may be equal to zero. |
| FILED | Thursday, January 27, 2022 |
| APPL NO | 17/586069 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/24 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/4213 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220235093 | Wright et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Aaron T. Wright (Richland, Washington); Kristoffer R. Brandvold (Richland, Washington); Susan Ramos-Hunter (Boston, Massachusetts) |
| ABSTRACT | Probe embodiments for targeting, identifying, and isolating enzymes exhibiting BSH activity as well as devices and kits that use the probes are described herein. Methods of making and using the probes, devices, and kits are also described. In some embodiments, probes, devices, and kits for targeting, identifying, and isolating enzymes in a biological sample are disclosed. In some embodiments, compositions and methods of treatment using the probes, devices, and kits disclosed herein are described. |
| FILED | Wednesday, September 08, 2021 |
| APPL NO | 17/469297 |
| CURRENT CPC | Steroids C07J 9/005 (20130101) C07J 41/0066 (20130101) Original (OR) Class C07J 43/00 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/34 (20130101) Enzymes C12Y 301/02026 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/92 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220235493 | Dai et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee); University of Tennessee Research Foundation (Knoxville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sheng Dai (Knoxville, Tennessee); Huimin Luo (Knoxville, Tennessee); Halie J. Martin (Huntsville, Alabama) |
| ABSTRACT | A method for producing polyacrylonitrile (PAN) fiber, the method comprising: (i) mixing PAN with an ionic liquid in which the PAN is soluble to produce a PAN composite melt in which the PAN is dissolved in the ionic liquid; (ii) melt spinning the PAN composite melt to produce the PAN fiber; and (iii) washing the PAN fiber with a solvent in which the ionic liquid is soluble to substantially remove the ionic liquid from the PAN fiber. Also described herein is a method for producing carbon fiber from the PAN fiber as produced above, the method comprising oxidatively stabilizing the PAN fiber produced in step (iii), followed by carbonizing the stabilized PAN fiber to produce the carbon fiber. The initially produced PAN fiber, stabilized PAN fiber, resulting carbon fiber, and articles made thereof are also described. |
| FILED | Friday, January 21, 2022 |
| APPL NO | 17/580851 |
| CURRENT CPC | Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/10 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 6/54 (20130101) Original (OR) Class Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles D10B 2321/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220235516 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| INVENTOR(S) | Xiaodong Li (Charlottesville, Virginia); Zan Gao (Willimantic, Connecticut); Jiadeng Zhu (Charlottesville, Virginia); Yellapu V. Murty (Charlottesville, Virginia); Kenneth Brown (Charlottesville, Virginia); Clifton Bumgardner (Charlottesville, Virginia) |
| ABSTRACT | A new technique for treating non-PAN-based pre-cursor polymeric fibers, tows, yarns, and films has been created for use in making stabilized pre-cursor polymers. By applying stepwise or non-stepwise microwave and/or ultraviolet radiation to the pre-cursor polymeric fibers, tows, yarn, or films prior to the stabilization thereof, a reduction in time for the costly stabilization process is achieved. Application of this technique extends to less-costly production of carbon fibers, for uses in industries such as automotive, aviation, trains, medical, military, sporting goods, orthopedics, and other industries. The pre-cursor polymeric fibers, tows, yarns, or films may be a multi-component polymer composite comprised of a non-PAN-based polymeric fiber, tow, yarn, or film and at least one or more constituent materials. Carbonization of such pre-cursor polymeric fibers, tows, yarns, or films results in less-costly carbon fibers that perform equally, if not better, than traditional costly PAN-based carbon fibers. |
| FILED | Wednesday, June 10, 2020 |
| APPL NO | 17/617192 |
| CURRENT CPC | Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 9/22 (20130101) Treatment, Not Provided for Elsewhere in Class D06, of Fibres, Threads, Yarns, Fabrics, Feathers or Fibrous Goods Made From Such Materials D06M 10/001 (20130101) Original (OR) Class Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles D10B 2101/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220235746 | Anderson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | 247Solar Inc. (Great Falls, Virginia) |
| ASSIGNEE(S) | 247Solar Inc. (Great Falls, Virginia) |
| INVENTOR(S) | Bruce N. Anderson (Great Falls, Virginia); William Dean Treece (La Mesa, California); Dan Brown (Lebanon, New Hampshire); Florian Bennhold (Osnabruk, Germany); Christoph Hilgert (Odenthal, Germany) |
| ABSTRACT | Inventive concentrated solar power systems using solar receivers, and related devices and methods, are generally described. Low pressure solar receivers are provided that function to convert solar radiation energy to thermal energy of a working fluid, e.g., a working fluid of a power generation or thermal storage system. In some embodiments, low pressure solar receivers are provided herein that are useful in conjunction with gas turbine based power generation systems. |
| FILED | Monday, February 07, 2022 |
| APPL NO | 17/666426 |
| CURRENT CPC | Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 1/04 (20130101) F02C 1/08 (20130101) Spring, Weight, Inertia or Like Motors; Mechanical-power Producing Devices or Mechanisms, Not Otherwise Provided for or Using Energy Sources Not Otherwise Provided for F03G 6/06 (20130101) Original (OR) Class F03G 6/064 (20130101) Solar Heat Collectors; Solar Heat Systems F24S 10/40 (20180501) F24S 10/80 (20180501) F24S 20/20 (20180501) F24S 23/79 (20180501) F24S 70/12 (20180501) F24S 80/20 (20180501) Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 19/04 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/40 (20130101) Y02E 10/44 (20130101) Y02E 10/46 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220235747 | Bahar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | FFI IONIX IP, INC. (Wilmington, Delaware) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bamdad Bahar (Georgetown, Delaware); William Parmelee (Orleans, Massachusetts) |
| ABSTRACT | An electrochemical heat transfer device for a hot water tank utilizes an electrochemical hydrogen compressor to pump hydrogen into and out of a tank having a metal hydride forming alloy therein. The absorption of hydrogen by the metal hydride forming alloy is exothermic, produces heat, and the desorption of the hydrogen from the metal hydride forming alloy is endothermic and draws heat in. An electrochemical hydrogen compressor may be configured between to tanks and pump hydrogen back and forth to form a heat transfer device, such as a hot water heater. A heat transfer device may be coupled with the tank or may comprise the outer surface of the tank to transfer heat to an object or to the surroundings. A closed loop may be configured having two tanks and one or two electrochemical hydrogen compressors to pump the hydrogen in a loop around the system. |
| FILED | Monday, March 07, 2022 |
| APPL NO | 17/687871 |
| CURRENT CPC | Separation B01D 53/261 (20130101) Spring, Weight, Inertia or Like Motors; Mechanical-power Producing Devices or Mechanisms, Not Otherwise Provided for or Using Energy Sources Not Otherwise Provided for F03G 7/012 (20210801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220236641 | Mirkin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chad A. Mirkin (Wilmette, Illinois); Rustin Golnabi (Evanston, Illinois); Eun Bi Oh (Evanston, Illinois); David Alan (Evanston, Illinois) |
| ABSTRACT | Disclosed herein is a massively parallel patterning tool for the deposition of single metals or metal alloys with size and composition control. Methods of the disclosure use a hydrogel array of pyramidal pen tips as a medium for localized electrodeposition, in conjunction with a scanning probe lithography platform and a three-electrode cell. This versatile technique can be used for high-throughput 3D printing, biomolecule patterning, or screening of catalyst nanoparticles or thin films. |
| FILED | Wednesday, January 26, 2022 |
| APPL NO | 17/585316 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 33/38 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/0002 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220237711 | Frolik et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Vermont and State Agricultural College (Burlington, Vermont) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeff Frolik (Essex Junction, Vermont); Paul Hines (Burlington, Vermont); Mads Almassalkhi (South Burlington, Vermont) |
| ABSTRACT | The present disclosure provides a distributed and anonymous approach to demand response of an electricity system. The approach conceptualizes energy consumption and production of distributed-energy resources (DERs) via discrete energy packets that are coordinated by a cyber computing entity that grants or denies energy packet requests from the DERs. The approach leverages a condition of a DER, which is particularly useful for (1) thermostatically-controlled loads, (2) non-thermostatic conditionally-controlled loads, and (3) bi¬directional distributed energy storage systems. In a first aspect of the present approach, each DER independently requests the authority to switch on for a fixed amount of time (i.e., packet duration). The coordinator determines whether to grant or deny each request based electric grid and/or energy or power market conditions. In a second aspect, bi-directional DERs, such as distributed-energy storage systems (DESSs) are further able to request to supply energy to the grid. |
| FILED | Thursday, November 11, 2021 |
| APPL NO | 17/454563 |
| CURRENT CPC | Electric Digital Data Processing G06F 17/18 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 50/06 (20130101) Original (OR) Class Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/00 (20130101) H02J 3/003 (20200101) H02J 3/14 (20130101) H02J 13/00 (20130101) Climate Change Mitigation Technologies Related to Buildings, e.g Housing, House Appliances or Related End-user Applications Y02B 70/3225 (20130101) Systems Integrating Technologies Related to Power Network Operation, Communication or Information Technologies for Improving the Electrical Power Generation, Transmission, Distribution, Management or Usage, i.e Smart Grids Y04S 20/222 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220238183 | Franco et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Laboratory (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Magdalena Franco (Livermore, California); Nicole Collette (Livermore, California); Patrik D'haeseleer (Livermore, California) |
| ABSTRACT | A newly developed generalizable screening method enables efficient identification of epitopes, in the proteomes of pathogenic agent is provided. Also disclosed are systems that enable the method as well as epitopes discovered using the method. |
| FILED | Thursday, January 27, 2022 |
| APPL NO | 17/586687 |
| CURRENT CPC | Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 40/10 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/30 (20190201) Original (OR) Class G16B 40/20 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220238241 | ALESHIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Westinghouse Electric Company LLC (Cranberry Township, Pennsylvania) |
| ASSIGNEE(S) | Westinghouse Electric Company LLC (Cranberry Township, Pennsylvania) |
| INVENTOR(S) | Yuriy ALESHIN (Cayce, South Carolina); Stuart KELLNER (Pittsburgh, Pennsylvania) |
| ABSTRACT | A nuclear reactor core mechanical support bracket is disclosed. The support bracket includes a housing, a spring disposed internally within the housing, a shaft slidingly disposed within the housing and to engage the spring to compress and decompress the spring as the shaft travels in and out of the housing, a shaft travel pin to control the travel of the shaft, and a flange to mount the support bracket to a canister of a nuclear reactor. The shaft includes an inset configured to interface with a nuclear reactor core component. |
| FILED | Monday, January 25, 2021 |
| APPL NO | 17/156977 |
| CURRENT CPC | Nuclear Reactors G21C 3/12 (20130101) Original (OR) Class G21C 3/324 (20130101) G21C 3/332 (20130101) G21C 3/3225 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220238262 | Pathak et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arjun K. Pathak (Willamsville, New York); Yaroslav Mudryk (Ames, Iowa); Oleksandr Dolotko (Karlsruhe, Germany); Vitalij K. Pecharsky (Ames, Iowa) |
| ABSTRACT | A magnetocaloric material comprising a La—Fe—Si based alloy composition that is compositionally modified to include a small but effective amount of at least one of Al, Ga, and In to improve mechanical stability of the alloy (substantially reduce alloy brittleness), improve thermal conductivity, and preserve comparable or provide improved magnetocaloric effects. The alloy composition may be further modified by inclusion of at least one of Co, Mn, Cr, and V as well as interstitial hydrogen. |
| FILED | Wednesday, February 16, 2022 |
| APPL NO | 17/803110 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 70/00 (20141201) Alloys C22C 33/04 (20130101) C22C 38/02 (20130101) C22C 38/005 (20130101) C22C 38/06 (20130101) C22C 2202/02 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 1/015 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220238336 | PTAK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado); Colorado School of Mines (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aaron Joseph PTAK (Littleton, Colorado); Corinne Evelyn PACKARD (Lakewood, Colorado) |
| ABSTRACT | Described herein are devices and methods for facet suppression in spalling of (100) GaAs by redirecting the fracture front along features created by buried nanoimprint lithography (NIL)-patterned SiO2. Successful facet suppression using patterns that result in favorable fracture along the SiO2/GaAs interface and/or through voids formed above the pattern in the coalesced layer is provided. These results allow for the design of patterns that would successfully interrupt the fracture front and suppress faceting that, combined with growth optimization, define a path forward for this technology to be used as a way to reduce the need for repreparation of the (100) GaAs substrate surface after spalling. |
| FILED | Wednesday, January 26, 2022 |
| APPL NO | 17/585096 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0243 (20130101) H01L 21/02422 (20130101) H01L 21/02546 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220238537 | Dowben et al. |
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| FUNDED BY |
|
| APPLICANT(S) | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (Lincoln, Nebraska); BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas); GEORGIA TECH RESEARCH CORPORATION (Atlanta, Georgia); THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Indiana); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter A. Dowben (Crete, Nebraska); Ruihua Cheng (Indianapolis, Indiana); Xiaoshan Xu (Lincoln, Nebraska); Alpha T. N'Diaye (Berkeley, California); Aaron Mosey (Indianapolis, Indiana); Guanhua Hao (Lincoln, Nebraska); Thilini K. Ekanayaka (Lincoln, Nebraska); Xuanyuan Jiang (Gainesville, Florida); Andrew J. Yost (Stillwater, Oklahoma); Andrew Marshall (Dallas, Texas); Azad J. Naeemi (Atlanta, Georgia) |
| ABSTRACT | A thin film molecular memory is provided that satisfies criteria needed to make a molecular spintronic device, based on spin crossover complexes, competitive with silicon technology. These criteria include, device implementation, a low coercive voltage (less than 1V) and low write peak currents (on the order of 104 A/cm2), a device on/off ratio >10, thin film quality, the ability to “lock” the spin state (providing nonvolatility), the ability to isothermally “unlock” and switch the spin state with voltage, conductance change with spin state, room temperature and above room temperature operation, an on-state device resistivity less than 1 Ω·cm, a device fast switching speed (less than 100 ps), device endurance (on the order of 1016 switches without degradation), and the ability of having a device with a transistor channel width of 10 nm or below. |
| FILED | Tuesday, January 25, 2022 |
| APPL NO | 17/583858 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/1159 (20130101) Original (OR) Class H01L 29/516 (20130101) H01L 29/78391 (20140902) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220238807 | Christensen et al. |
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| FUNDED BY |
|
| APPLICANT(S) | Energy Materials Corporation (Rochester, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott Kenneth Christensen (North Chili, New York); Qi Li (Rochester, New York); Thomas Nathaniel Tombs (Rochester, New York); Stephan J. DeLuca (Meadville, Pennsylvania) |
| ABSTRACT | A method of making a perovskite layer includes providing a flexible substrate; providing a perovskite solution comprising an initial amount of solvent and perovskite precursor materials and a total solids concentration between 30 percent and 70 percent by weight of its saturation concentration; depositing the perovskite solution on the substrate; removing a first portion of the solvent from the deposited perovskite solution and increasing the total solids concentration of the perovskite solution to at least 75 percent of its saturation concentration with a first drying step; and removing a second portion of the solvent from the deposited perovskite solution with a second drying step having a higher rate of solvent evaporation that causes saturation and a conversion reaction in the deposited perovskite solution resulting in perovskite crystal formation or formation of a perovskite intermediate phase, wherein the first drying step dwell time is at least 5 times longer than the second drying step dwell time. A continuous inline method for production of photovoltaic devices at high speed, and a perovskite solution for use in making a uniform Perovskite layer at high speed to enable low cost production of high efficiency Perovskite devices are also described. |
| FILED | Thursday, May 28, 2020 |
| APPL NO | 17/615142 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/24 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0007 (20130101) H01L 51/0027 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220238823 | FERGUSON et al. |
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| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew John FERGUSON (Louisville, Colorado); Jeffrey Lee BLACKBURN (Golden, Colorado); Ji HAO (Santa Clara, California) |
| ABSTRACT | Electronic ratchet devices comprising a pair of first and second electrodes; a dielectric layer; a gate electrode layer; and a transport layer are disclosed herein. |
| FILED | Friday, May 22, 2020 |
| APPL NO | 17/613621 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/055 (20130101) H01L 51/105 (20130101) H01L 51/0525 (20130101) H01L 51/0545 (20130101) H01L 51/0566 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220238833 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jian Li (Tempe, Arizona); Tyler Fleetham (Gilbert, Arizona) |
| ABSTRACT | A light emitting device includes a first electrode, a hole transporting layer in contact with the first electrode, a second electrode, an electron transporting layer in contact with the second electrode; and an emissive layer between the hole transporting layer and the electron transporting layer. The emissive layer includes a phosphorescent emitter, a fluorescent emitter, and a host, and the phosphorescent emitter harvests electrogenerated excitons and transfers energy to the fluorescent emitter. |
| FILED | Friday, April 08, 2022 |
| APPL NO | 17/716638 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) C09K 2211/185 (20130101) C09K 2211/1011 (20130101) C09K 2211/1029 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0059 (20130101) H01L 51/0072 (20130101) H01L 51/508 (20130101) H01L 51/5012 (20130101) H01L 51/5016 (20130101) H01L 51/5028 (20130101) H01L 51/5064 (20130101) Original (OR) Class H01L 51/5088 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220239587 | Roweth et al. |
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| FUNDED BY |
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| APPLICANT(S) | Hewlett Packard Enterprise Development LP (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Duncan Roweth (Bristol Avon, United Kingdom); Edwin L. Froese (Burnaby British Columbia, Canada); Joseph G. Kopnick (Chippewa Falls, Wisconsin); Andrew S. Kopser (Seattle, Washington); Robert Alverson (Seattle, Washington) |
| ABSTRACT | Systems and methods are provided for passing data amongst a plurality of switches having a plurality of links attached between the plurality of switches. At a switch, a plurality of load signals are received from a plurality of neighboring switches. Each of the plurality of load signals are made up of a set of values indicative of a load at each of the plurality of neighboring switches providing the load signal. Each value within the set of values provides an indication for each link of the plurality of links attached thereto as to whether the link is busy or quiet. Based upon the plurality of load signals, an output link for routing a received packet is selected, and the received packet is routed via the selected output link. |
| FILED | Monday, March 23, 2020 |
| APPL NO | 17/594736 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 45/22 (20130101) Original (OR) Class H04L 47/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20220233727 | Thakor et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Avnesh S. Thakor (Redwood City, California); Mehdi Razavi (Redwood City, California) |
| ABSTRACT | Surface enhanced Raman scattering (SERS) nanoparticles and methods of using them for detecting reactive oxygen species are disclosed. In particular, methods of using SERS nanoparticles to detect and quantify reactive oxygen species Synthesis and monitor oxidative stress and disease-relevant changes in levels of reactive oxygen species are provided. |
| FILED | Wednesday, June 10, 2020 |
| APPL NO | 17/617462 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0075 (20130101) A61B 6/481 (20130101) A61B 6/4057 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 49/0041 (20130101) A61K 49/0056 (20130101) A61K 49/0093 (20130101) A61K 51/088 (20130101) Original (OR) Class A61K 51/1244 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/658 (20130101) G01N 33/574 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220234007 | KORNFIELD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Julia A. KORNFIELD (Pasadena, California); Katherine T. FABER (Pasadena, California); Mamadou DIALLO (Pasadena, California); Orland BATEMAN (Pasadena, California); Noriaki ARAI (Pasadena, California) |
| ABSTRACT | A composite, method of making the composite, and method of using the composite are disclosed. The composite comprises a macroporous scaffold comprising pores; and a polymer matrix positioned within the pores; wherein the polymer matrix comprises: a functional polymer particle; and a structural polymer. The method of using can comprise applications such as chromatography, catalysis, and sensing, among others. |
| FILED | Tuesday, December 21, 2021 |
| APPL NO | 17/558186 |
| CURRENT CPC | Separation B01D 15/361 (20130101) B01D 15/3809 (20130101) B01D 69/12 (20130101) Original (OR) Class B01D 71/34 (20130101) B01D 71/60 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/06 (20130101) B01J 31/1691 (20130101) B01J 37/009 (20130101) Peptides C07K 1/22 (20130101) Compositions of Macromolecular Compounds C08L 27/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220234103 | Wei et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wei David Wei (Gainesville, Florida); Yueming Zhai (Gainesville, Florida) |
| ABSTRACT | In one aspect, the present disclosure pertains to methods of making various noble metal nanoprisms, e.g., gold nanoprisms. In various aspects, the methods can comprise incubating, under dark conditions, a growth solution comprising: (a) a plurality of gold seed structures; (b) a gold precursor, and (c) a photocatalytic intermediary, such that during the incubating step multiply-twinned gold seed structures in the growth solution are preferentially enlarged. The disclosed methods can comprise separating the multiply-twinned gold seed structures from the growth solution based upon the size of the gold seed structures to produce an enriched growth solution. In some aspects, the methods comprise irradiating the enriched growth solution to produce the gold nanoprisms. In some aspects, the disclosed nanoprisms comprise silver. |
| FILED | Monday, March 14, 2022 |
| APPL NO | 17/694162 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/054 (20220101) B22F 9/24 (20130101) Original (OR) Class Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Production and Refining of Metals; Pretreatment of Raw Materials C22B 11/04 (20130101) Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 7/14 (20130101) C30B 29/66 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220234962 | Faber et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Califomia Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | Califomia Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Katherine T. Faber (Pasadena, California); Julia A. Kornfield (Pasadena, California); Noriaki Arai (Pasadena, California); Orland Bateman (Pasadena, California); Rustem F. Ismagilov (Pasadena, California) |
| ABSTRACT | Provided herein are methods for making a freeze-cast material having a internal structure, the methods comprising steps of: determining the internal structure of the material, the internal structure having a plurality of pores, wherein: each of the plurality of pores has directionality; and the step of determining comprises: selecting a temperature gradient and a freezing front velocity to obtain the determined internal structure based on the selected temperature gradient and the selected freezing front velocity; directionally freezing a liquid formulation to form a frozen solid, the step of directionally freezing comprising: controlling the temperature gradient and the freezing front velocity to match the selected temperature gradient and the selected freezing front velocity during directionally freezing; wherein the liquid formulation comprises at least one solvent and at least one dispersed species; and subliming the at least one solvent out of the frozen solid to form the material. |
| FILED | Thursday, December 23, 2021 |
| APPL NO | 17/560956 |
| CURRENT CPC | Separation B01D 67/0051 (20130101) B01D 69/02 (20130101) B01D 71/024 (20130101) B01D 2325/021 (20130101) B01D 2325/26 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 35/04 (20130101) B01J 35/1071 (20130101) B01J 35/1076 (20130101) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 38/007 (20130101) C04B 38/0038 (20130101) C04B 38/0054 (20130101) C04B 38/0093 (20130101) C04B 38/0605 (20130101) Original (OR) Class Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/14 (20130101) H01B 1/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220235353 | Hochrein et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lisa Hochrein (Pasadena, California); Heyun Li (Pasadena, California); Evan Mun (Pasadena, California); Paul W. Rothemund (Pasadena, California); Niles A. Pierce (Pasadena, California) |
| ABSTRACT | Nucleic acids (DNA and RNA) provide a versatile platform for engineering synthetic biology in a variety of technology areas including medicine, science, agriculture, and energy. In many settings, degradation of nucleic acid molecules poses a significant engineering challenge as the molecules do not function if they have been degraded. In some embodiments, nucleic acid protective elements (PELs) are used to protect chemically synthesized or expressed nucleic acid molecules from degradation. PELs may be derived from all or part of a viral xrRNA sequence and/or structural motif, PELs may include rationally designed sequences and/or structural motifs, PELs may be engineered using directed evolution, and in some embodiments, PELs comprise a mixture of biologically derived, rationally designed sequence and/or structural motifs, and/or sequences and/or structural motifs that are engineered by directed evolution. In some embodiments, PELs significantly enhance the performance of nucleic acid synthetic biology, protecting nucleic acid regulatory and/or structural elements from degradation to increase regulatory dynamic range, fractional dynamic range, fold-change, and/or other performance metrics. In some embodiments, PELs that reduce nucleic acid degradation provide a platform technology for enhancing the performance of synthetic biology, with applications including therapeutics, diagnostics, biological research tools, vaccines, crop protection, molecular manufacturing, sustainable energy production, and other areas involving nucleic acids. |
| FILED | Tuesday, January 25, 2022 |
| APPL NO | 17/584271 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/102 (20130101) C12N 15/111 (20130101) Original (OR) Class C12N 15/113 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220235384 | Nagpal et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Prashant Nagpal (Lafayette, Colorado); Yuchen Ding (Boulder, Colorado); John Bertram (Broomfield, Colorado) |
| ABSTRACT | The invention relates to a nano-biohybrid organism (or nanorg) comprising one of at least seven different core-shell quantum dots (QDs) or gold nanoparticle clusters, with excitations ranging from ultraviolet to near-infrared energies, couple with targeted enzyme sites in bacteria. When illuminated by light, these QDs drive the renewable production of biofuel molecules and chemicals using carbon-dioxide (CO2), water, and nitrogen (from air) as substrates. Nanorgs catalyze light-induced air-water-CO2 reduction with a high turnover number (TON) of approximately 106-108 (mols of product per mol of cells) to biofuels such as isopropanol (IPA), butane diol, gasoline additives, gasoline substitutes, 2,3-butanediol (BDO), C11-C15 methyl ketones (MKs), and hydrogen (H2); Sand chemicals such as formic acid (FA), ammonia (NH3), ethylene (C2H4), and degradable bioplastics, e.g. polyhydroxybutyrate (PHB). These nanorg cells function as nano-microbial factories powered by light. |
| FILED | Thursday, May 14, 2020 |
| APPL NO | 17/611109 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 1/38 (20130101) C12N 9/0095 (20130101) C12N 15/74 (20130101) C12N 2800/101 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 3/00 (20130101) C12P 7/625 (20130101) Original (OR) Class Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/065 (20210501) Enzymes C12Y 118/06001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220235472 | Chen |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of South Carolina (Columbia, South Carolina) |
| ASSIGNEE(S) | University of South Carolina (Columbia, South Carolina) |
| INVENTOR(S) | Fanglin Chen (Irmo, South Carolina) |
| ABSTRACT | Described herein is an electrochemical process to improve the yields obtained while converting ethane to ethylene with high yield, which utilizes CO2 to make CO concurrently, while solving the low conversion, low selectivity, and catalyst coking challenges for conversion ethane to ethylene currently present in the petrochemical industry. |
| FILED | Tuesday, November 23, 2021 |
| APPL NO | 17/533432 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/02 (20130101) C25B 1/23 (20210101) C25B 3/03 (20210101) Original (OR) Class C25B 3/26 (20210101) C25B 11/047 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220236215 | Thomas et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| ASSIGNEE(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| INVENTOR(S) | Jayan Thomas (Orlando, Florida); Jinxin Li (Orlando, Florida); Foram Madiyar (Port Orange, Florida) |
| ABSTRACT | One type of plasmonic organic electrochemical transistor (POECT) includes a channel comprising an organic semiconductor, a gate electrode comprising at least one of: an ensemble of nanoparticles and an array of nanostructures, wherein each of the at least one of: an ensemble of nanoparticles and an array of nanostructures comprises localized plasmonic material, an analyte formed at least one of: (a) over the at least one of: the ensemble of nanoparticles and the array of nanostructures and (b) around the at least one of: the ensemble of nanoparticles and the array of nanostructures, wherein an electrolyte is configured to be formed at least one of: between the channel and the gate electrode and over the channel and the gate electrode, a source electrode electrically connected to a first end of the channel; and a drain electrode electrically connected to a second end of the channel which is opposite the first end. |
| FILED | Monday, November 22, 2021 |
| APPL NO | 17/532141 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/4146 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220237258 | Siskind et al. |
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| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana); National University of Ireland Maynooth (Kildare, Ireland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey Siskind (West Lafayette, Indiana); Barak Pearlmutter (Dublin, Ireland) |
| ABSTRACT | A system and method for automatic differentiation are disclosed. The system and method provide automatic differentiation (AD) that accurately supports functions whose domains and/or ranges are functions. The system and method advantageously enable AD that is completely general and which can be applied in an unrestricted fashion to correctly compute the derivative of all programs that compute differentiable mathematical functions. This includes application to functions whose domain and/or ranges include the entire space of data types supported by programming languages, including not only aggregates but also functions. Moreover, the system and method advantageously remedy an insidious bug that would otherwise lead to incorrect results. |
| FILED | Wednesday, April 29, 2020 |
| APPL NO | 17/607272 |
| CURRENT CPC | Electric Digital Data Processing G06F 17/13 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220237711 | Frolik et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Vermont and State Agricultural College (Burlington, Vermont) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeff Frolik (Essex Junction, Vermont); Paul Hines (Burlington, Vermont); Mads Almassalkhi (South Burlington, Vermont) |
| ABSTRACT | The present disclosure provides a distributed and anonymous approach to demand response of an electricity system. The approach conceptualizes energy consumption and production of distributed-energy resources (DERs) via discrete energy packets that are coordinated by a cyber computing entity that grants or denies energy packet requests from the DERs. The approach leverages a condition of a DER, which is particularly useful for (1) thermostatically-controlled loads, (2) non-thermostatic conditionally-controlled loads, and (3) bi¬directional distributed energy storage systems. In a first aspect of the present approach, each DER independently requests the authority to switch on for a fixed amount of time (i.e., packet duration). The coordinator determines whether to grant or deny each request based electric grid and/or energy or power market conditions. In a second aspect, bi-directional DERs, such as distributed-energy storage systems (DESSs) are further able to request to supply energy to the grid. |
| FILED | Thursday, November 11, 2021 |
| APPL NO | 17/454563 |
| CURRENT CPC | Electric Digital Data Processing G06F 17/18 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 50/06 (20130101) Original (OR) Class Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/00 (20130101) H02J 3/003 (20200101) H02J 3/14 (20130101) H02J 13/00 (20130101) Climate Change Mitigation Technologies Related to Buildings, e.g Housing, House Appliances or Related End-user Applications Y02B 70/3225 (20130101) Systems Integrating Technologies Related to Power Network Operation, Communication or Information Technologies for Improving the Electrical Power Generation, Transmission, Distribution, Management or Usage, i.e Smart Grids Y04S 20/222 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220237885 | Fathi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Pointivo, Inc. (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Habib Fathi (Atlanta, Georgia); Miguel M. Serrano (Marietta, Georgia); Bradden John Gross (Atlanta, Georgia); Daniel L. Ciprari (Atlanta, Georgia) |
| ABSTRACT | Examples of various method and systems are provided for information extraction from scene information. 2D image information can be generated from 2D images of the scene that are overlapping at least part of one or more object(s). The 2D image information can be combined with 3D information about the scene incorporating at least part of the object(s) to generate projective geometry information. Clustered 3D information associated with the object(s) can be generated by partitioning and grouping 3D data points present in the 3D information. The clustered 3D information can be used to provide, e.g., measurement information, dimensions, geometric information, and/or topological information about the object(s). Segmented 2D information can also be generated from the 2D image information. Validated 2D and 3D information can be produced by cross-referencing between the projective geometry information, clustered 3D information, and/or segmented 2D image information, and used to label the object(s) in the scene. |
| FILED | Monday, February 07, 2022 |
| APPL NO | 17/665653 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6218 (20130101) Image Data Processing or Generation, in General G06T 7/55 (20170101) G06T 17/00 (20130101) G06T 2207/10028 (20130101) Image or Video Recognition or Understanding G06V 10/267 (20220101) Original (OR) Class G06V 20/10 (20220101) G06V 20/64 (20220101) G06V 20/647 (20220101) G06V 2201/12 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220238110 | Duval |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jared Duval (Santa Cruz, California) |
| ABSTRACT | A computer-implemented method can include: an audio input device of a portable electronic device receiving verbal speech input from a user and converting the received verbal speech input into an audio input signal; an online processing module of the portable electronic device performing at least one speech recognition operation on the audio input signal; an offline processing module of the portable electronic device performing at least one speech recognition operation on the audio input signal; an interactive game module of the portable electronic device generating user feedback based on results from the at least one speech recognition operation performed by the online processing module and the at least one speech recognition operation by the offline processing module; and a user interface of the portable electronic device providing the user feedback to the user. |
| FILED | Monday, January 24, 2022 |
| APPL NO | 17/648798 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 13/80 (20130101) Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 15/005 (20130101) G10L 15/22 (20130101) Original (OR) Class G10L 15/063 (20130101) G10L 2015/225 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220238245 | Endres et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Manuel Endres (Pasadena, California); Alexandre Cooper-Roy (Downey, California); Jacob P. Covey (Pasadena, California); Ivaylo S. Madjarov (Pasadena, California); Adam L. Shaw (Pasadena, California); Vladimir Schkolnik (Pasadena, California); Jason R. Williams (Castaic, California); Joonhee Choi (Pasadena, California) |
| ABSTRACT | An apparatus useful for creating and measuring states of an entangled system, comprising a pair of interacting multi-level systems, each of systems comprising a state |g>; a state |r>, and state |r*>. One or more first electromagnetic fields excite a first transition between the ground state |g> and the state |r> to create an entangled system. One or more second electromagnetic fields are tuned between the state |r> and the intermediate state |r*> so that any population of the systems in |r*> are dark to a subsequent detection of a population in the systems in |g>, providing a means to distinguish the entangled system in the state |g> and the entangled system in the state |r>. In one or more examples, the systems comprise neutral Rydberg atoms. |
| FILED | Wednesday, February 10, 2021 |
| APPL NO | 17/172885 |
| CURRENT CPC | Techniques for Handling Particles or Ionising Radiation Not Otherwise Provided For; Irradiation Devices; Gamma Ray or X-ray Microscopes G21K 1/003 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220238246 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Worcester Polytechnic Institute (Worcester, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yuxiang Liu (Worcester, Massachusetts); Chaoyang Ti (Shrewsbury, Massachusetts); Qi Wen (Shrewsbury, Massachusetts) |
| ABSTRACT | A fiber optic based particle manipulation system employs one or more optical fibers for emanating a refracted optical manipulation signal directed at a target particle for fixing or manipulating the particle for examination, research and manufacturing. A target particle may be a living cell or inanimate sample or compound of matter. An alignment linkage controls optical fibers carrying the manipulation signal for focusing one or more manipulation signals on the target particle. Manipulated particles occupy a fluid medium of either liquid or gas, and are responsive to the manipulation signal based on both photon bombardment and temperature differential from photon contact. The temperature differential is based on surface properties of the target particle, as smooth particles tend to exhibit a greater thermal differential for stronger displacement forces driving or affecting the target particle. |
| FILED | Wednesday, January 26, 2022 |
| APPL NO | 17/585056 |
| CURRENT CPC | Techniques for Handling Particles or Ionising Radiation Not Otherwise Provided For; Irradiation Devices; Gamma Ray or X-ray Microscopes G21K 1/006 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220238537 | Dowben et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (Lincoln, Nebraska); BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas); GEORGIA TECH RESEARCH CORPORATION (Atlanta, Georgia); THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Indiana); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter A. Dowben (Crete, Nebraska); Ruihua Cheng (Indianapolis, Indiana); Xiaoshan Xu (Lincoln, Nebraska); Alpha T. N'Diaye (Berkeley, California); Aaron Mosey (Indianapolis, Indiana); Guanhua Hao (Lincoln, Nebraska); Thilini K. Ekanayaka (Lincoln, Nebraska); Xuanyuan Jiang (Gainesville, Florida); Andrew J. Yost (Stillwater, Oklahoma); Andrew Marshall (Dallas, Texas); Azad J. Naeemi (Atlanta, Georgia) |
| ABSTRACT | A thin film molecular memory is provided that satisfies criteria needed to make a molecular spintronic device, based on spin crossover complexes, competitive with silicon technology. These criteria include, device implementation, a low coercive voltage (less than 1V) and low write peak currents (on the order of 104 A/cm2), a device on/off ratio >10, thin film quality, the ability to “lock” the spin state (providing nonvolatility), the ability to isothermally “unlock” and switch the spin state with voltage, conductance change with spin state, room temperature and above room temperature operation, an on-state device resistivity less than 1 Ω·cm, a device fast switching speed (less than 100 ps), device endurance (on the order of 1016 switches without degradation), and the ability of having a device with a transistor channel width of 10 nm or below. |
| FILED | Tuesday, January 25, 2022 |
| APPL NO | 17/583858 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/1159 (20130101) Original (OR) Class H01L 29/516 (20130101) H01L 29/78391 (20140902) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220238857 | Meng |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Fayetteville, Arkansas) |
| ASSIGNEE(S) | BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Fayetteville, Arkansas) |
| INVENTOR(S) | Xiangbo Meng (Fayetteville, Arkansas) |
| ABSTRACT | Lithium-containing polymeric films and superionic inorganic lithium-conductors for protecting lithium metal electrodes, which lithium metal electrodes have little to no formation of SEI and dendrite growth. |
| FILED | Tuesday, January 25, 2022 |
| APPL NO | 17/584316 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/134 (20130101) Original (OR) Class H01M 4/137 (20130101) H01M 10/052 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220238868 | Cao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Guozhong Cao (Seattle, Washington); Chaofeng Liu (Seattle, Washington) |
| ABSTRACT | The present disclosure generally relates to cation-stabilized expanded hydrated vanadates, electrodes made therefrom, and batteries incorporating cathodes made from the cation-stabilized expanded hydrated vanadate. |
| FILED | Friday, May 15, 2020 |
| APPL NO | 17/606354 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/485 (20130101) Original (OR) Class H01M 10/36 (20130101) H01M 2004/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220239309 | Yang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| INVENTOR(S) | Zhi Yang (Minneapolis, Minnesota); Anh Tuan Nguyen (Minneapolis, Minnesota); Diu Khue Luu (Minneapolis, Minnesota); Jian Xu (Minneapolis, Minnesota) |
| ABSTRACT | A digital-to-analog converter device including a set of components, each component included in the set of components including a number of unit cells, each unit cell being associated with a unit cell size indicating manufacturing specifications of the unit cell is provided by the present disclosure. The digital-to-analog converter device further includes a plurality of switches, each switch included in the plurality of switches being coupled to a component included in the set of components, and an output electrode coupled to the plurality of switches. The digital-to-analog converter device is configured to output an output signal at the output electrode. A first unit cell size associated with a first unit cell included in the set of components is different than a second unit cell size associated with a second unit cell included in the set of components. |
| FILED | Tuesday, April 05, 2022 |
| APPL NO | 17/713524 |
| CURRENT CPC | Coding; Decoding; Code Conversion in General H03M 1/007 (20130101) H03M 1/46 (20130101) Original (OR) Class H03M 1/447 (20130101) H03M 1/802 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20220234315 | Hundley et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HRL LABORATORIES, LLC (Malibu, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jacob M. Hundley (Thousand Oaks, California); Alicia J. Dias (Boston, Massachusetts); Eric C. Clough (Santa Monica, California); Tobias A. Schaedler (Oak Park, California) |
| ABSTRACT | A method of forming a sandwich structure including at least partially filling an open volume of an open cellular core with a sacrificial mold material, consolidating the sacrificial mold material to form a sacrificial mold, laying up a composite facesheet on each of at least two surfaces of the open cellular core, co-curing the composite facesheets by applying a consolidation temperature and a compaction pressure to the composite facesheets to form the sandwich structure, and removing the sacrificial mold. The compaction pressure is greater than a compressive strength of the open cellular core and less than a combined compressive strength of the open cellular core and the sacrificial mold. |
| FILED | Tuesday, April 12, 2022 |
| APPL NO | 17/719101 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 33/3842 (20130101) B29C 70/682 (20130101) Original (OR) Class B29C 70/683 (20130101) B29C 70/685 (20130101) B29C 71/0009 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2063/00 (20130101) Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 3/12 (20130101) B32B 27/06 (20130101) B32B 27/38 (20130101) B32B 2250/03 (20130101) B32B 2250/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220235353 | Hochrein et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lisa Hochrein (Pasadena, California); Heyun Li (Pasadena, California); Evan Mun (Pasadena, California); Paul W. Rothemund (Pasadena, California); Niles A. Pierce (Pasadena, California) |
| ABSTRACT | Nucleic acids (DNA and RNA) provide a versatile platform for engineering synthetic biology in a variety of technology areas including medicine, science, agriculture, and energy. In many settings, degradation of nucleic acid molecules poses a significant engineering challenge as the molecules do not function if they have been degraded. In some embodiments, nucleic acid protective elements (PELs) are used to protect chemically synthesized or expressed nucleic acid molecules from degradation. PELs may be derived from all or part of a viral xrRNA sequence and/or structural motif, PELs may include rationally designed sequences and/or structural motifs, PELs may be engineered using directed evolution, and in some embodiments, PELs comprise a mixture of biologically derived, rationally designed sequence and/or structural motifs, and/or sequences and/or structural motifs that are engineered by directed evolution. In some embodiments, PELs significantly enhance the performance of nucleic acid synthetic biology, protecting nucleic acid regulatory and/or structural elements from degradation to increase regulatory dynamic range, fractional dynamic range, fold-change, and/or other performance metrics. In some embodiments, PELs that reduce nucleic acid degradation provide a platform technology for enhancing the performance of synthetic biology, with applications including therapeutics, diagnostics, biological research tools, vaccines, crop protection, molecular manufacturing, sustainable energy production, and other areas involving nucleic acids. |
| FILED | Tuesday, January 25, 2022 |
| APPL NO | 17/584271 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/102 (20130101) C12N 15/111 (20130101) Original (OR) Class C12N 15/113 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220235905 | Sullivan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mississippi State University (Starkville, Mississippi) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rani Warsi Sullivan (Starkville, Mississippi); Shuvam Saha (Starkville, Mississippi); Myles Baker (Long Beach, California); Adam Przekop (Yorktown, Virginia) |
| ABSTRACT | Provided herein are polymer matrix composites, articles including the polymer matrix composites, and methods of forming the polymer matrix composites. The polymer matrix composite includes a stitched composite and a hybrid barrier layer incorporated within the stitched composite, the hybrid barrier layer including a thin ply and a nanographene dispersed resin. The article includes a high-pressure composite cryogenic tank including the polymer matrix composite. The method includes positioning a dry thin ply between composite plies, stitching the composite plies to form a stitched preform, dispersing nanographene into the resin, and infusing the stitched preform with the modified resin. |
| FILED | Tuesday, January 04, 2022 |
| APPL NO | 17/568642 |
| CURRENT CPC | Preparation or Pretreatment of the Material to be Shaped; Making Granules or Preforms; Recovery of Plastics or Other Constituents of Waste Material Containing Plastics B29B 11/16 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 70/003 (20210501) B29C 70/48 (20130101) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2031/7156 (20130101) Vessels for Containing or Storing Compressed, Liquefied or Solidified Gases; Fixed-capacity Gas-holders; Filling Vessels With, or Discharging From Vessels, Compressed, Liquefied, or Solidified Gases F17C 1/16 (20130101) Original (OR) Class F17C 2203/0663 (20130101) F17C 2203/0697 (20130101) F17C 2209/2109 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220236453 | Alù et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Research Foundation of the City University of New York (New York, New York); Nanohmics Inc. (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrea Alù (Tenafly, New Jersey); Adam C. Overvig (Bronx, New York); Shuwei Guo (New York, New York); You Zhou (Jersey City, New Jersey); Mark Lucente (Austin, Texas) |
| ABSTRACT | A metasurface that is designed to control electromagnetic radiation (EMR) in ways that perform more than a single function. The metasurface has a substrate layer that has multiple asymmetric nanofeatures, each having a height (H) between λmin/100 and 2λmax. Each nanofeature has a particular length (Dy) that extends along a principal in-plane direction θ and a width (Dx) that is orthogonal thereto. Each nanofeature is tailored to scatter with different patterns one polarization state of electromagnetic radiation and one orthogonal polarization state of electromagnetic radiation. |
| FILED | Thursday, January 27, 2022 |
| APPL NO | 17/586374 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 1/002 (20130101) Original (OR) Class G02B 27/1006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220239541 | Moghaddam et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California); CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mahta Moghaddam (Los Angeles, California); Samuel M. Prager (Los Angeles, California); Mark S. Haynes (Pasadena, California) |
| ABSTRACT | This disclosure presents distributed and decentralized synchronization for wireless transceivers. The disclosed system, device, and method achieve sub-nanosecond synchronization using low-cost commercial off the shelf software defined radios. By providing a decentralized mechanism that does not rely on a hierarchical master-slave structure, networks constructed as disclosed are robust to sensor drop-out in contested or harsh environments. Such networks may be used to create phased array radars and communication systems without requiring wired connections to distribute a common clock or local oscillator reference. |
| FILED | Friday, January 14, 2022 |
| APPL NO | 17/576806 |
| CURRENT CPC | Transmission H04B 1/0003 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 27/266 (20130101) H04L 27/2663 (20130101) Original (OR) Class Wireless Communication Networks H04W 56/001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Security Agency (NSA)
| US 20220236761 | MONROE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher MONROE (Ellicott City, Maryland); Jiehang ZHANG (College Park, Maryland); David WONG-CAMPOS (Hyattsville, Maryland); Antonios KYPRIANIDIS (Takoma, Maryland); Patrick Michael BECKER (College Park, Maryland) |
| ABSTRACT | The disclosure describes an adaptive and optimal imaging of individual quantum emitters within a lattice or optical field of view for quantum computing. Advanced image processing techniques are described to identify individual optically active quantum bits (qubits) with an imager. Images of individual and optically-resolved quantum emitters fluorescing as a lattice are decomposed and recognized based on fluorescence. Expected spatial distributions of the quantum emitters guides the processing, which uses adaptive fitting of peak distribution functions to determine the number of quantum emitters in real time. These techniques can be used for the loading process, where atoms or ions enter the trap one-by-one, for the identification of solid-state emitters, and for internal state-detection of the quantum emitters, where each emitter can be fluorescent or dark depending on its internal state. This latter application is relevant to efficient and fast detection of optically active qubits in quantum simulations and quantum computing. |
| FILED | Thursday, October 28, 2021 |
| APPL NO | 17/513496 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) B82Y 40/00 (20130101) Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 1/42 (20130101) G01J 2001/4247 (20130101) Optical Computing Devices; G06E 3/005 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/66977 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220239587 | Roweth et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hewlett Packard Enterprise Development LP (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Duncan Roweth (Bristol Avon, United Kingdom); Edwin L. Froese (Burnaby British Columbia, Canada); Joseph G. Kopnick (Chippewa Falls, Wisconsin); Andrew S. Kopser (Seattle, Washington); Robert Alverson (Seattle, Washington) |
| ABSTRACT | Systems and methods are provided for passing data amongst a plurality of switches having a plurality of links attached between the plurality of switches. At a switch, a plurality of load signals are received from a plurality of neighboring switches. Each of the plurality of load signals are made up of a set of values indicative of a load at each of the plurality of neighboring switches providing the load signal. Each value within the set of values provides an indication for each link of the plurality of links attached thereto as to whether the link is busy or quiet. Based upon the plurality of load signals, an output link for routing a received packet is selected, and the received packet is routed via the selected output link. |
| FILED | Monday, March 23, 2020 |
| APPL NO | 17/594736 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 45/22 (20130101) Original (OR) Class H04L 47/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20220232846 | Krishnaswamy |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Curators of the University of Missouri (Columbia, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kiruba Krishnaswamy (Columbia, Missouri) |
| ABSTRACT | A method for forming an acid whey-based food product, the method comprising: (a) preparing a matrix suitable for spray drying, wherein the matrix is a homogenous mixture comprising acid whey and flour; and (b) spray drying the matrix to form a powder of dried matrix; thereby forming the acid whey-based food product that is a powder comprising particles, wherein each particle comprises homogeneous mixture of dried acid whey and flour. |
| FILED | Thursday, January 27, 2022 |
| APPL NO | 17/586675 |
| CURRENT CPC | Dairy Products, e.g Milk, Butter, Cheese; Milk or Cheese Substitutes; Making Thereof A23C 1/04 (20130101) A23C 21/06 (20130101) A23C 21/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20220233640 | Demorrow et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United State Govermment as represented by the Department of Veterans (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sharon Demorrow (Temple, Texas); Matthew McMillin (Harker Heights, Texas); Anca D. Petrescu (Temple, Texas) |
| ABSTRACT | In one aspect, the invention relates to pharmaceutical compositions comprising at least one agent that modulates GalR1 and/or GalR, which are useful for treating fibrotic disorders such as, for example, liver fibrosis. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| FILED | Thursday, April 16, 2020 |
| APPL NO | 17/604370 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1138 (20130101) C12N 2310/14 (20130101) C12N 2310/3233 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of the Interior (DOI)
| US 20220239541 | Moghaddam et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California); CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mahta Moghaddam (Los Angeles, California); Samuel M. Prager (Los Angeles, California); Mark S. Haynes (Pasadena, California) |
| ABSTRACT | This disclosure presents distributed and decentralized synchronization for wireless transceivers. The disclosed system, device, and method achieve sub-nanosecond synchronization using low-cost commercial off the shelf software defined radios. By providing a decentralized mechanism that does not rely on a hierarchical master-slave structure, networks constructed as disclosed are robust to sensor drop-out in contested or harsh environments. Such networks may be used to create phased array radars and communication systems without requiring wired connections to distribute a common clock or local oscillator reference. |
| FILED | Friday, January 14, 2022 |
| APPL NO | 17/576806 |
| CURRENT CPC | Transmission H04B 1/0003 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 27/266 (20130101) H04L 27/2663 (20130101) Original (OR) Class Wireless Communication Networks H04W 56/001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of the Treasury (TREASURY)
| US 20220237979 | Rich et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | WAVEFRONT TECHNOLOGY, INC. (Paramount, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Chapman Rich (Rancho Palos Verdes, California); Joel Mikael Petersen (Valley Village, California); Roger Winston Phillips (Santa Rosa, California); John Michael Tamkin (Pasadena, California) |
| ABSTRACT | An optical device includes an array of lenses and a plurality of first and second segments disposed under the array of lenses. At a first viewing angle, the array of lenses presents a first image for viewing without presenting the second image for viewing, and at a second viewing angle different from the first viewing angle, the array of lenses presents for viewing the second image without presenting the first image for viewing. In some examples, individual ones of the first and second segments can comprise specular reflecting, transparent, diffusely reflecting, and/or diffusely transmissive features. In some examples, individual ones of the first and second segments can comprise transparent and non-transparent regions. Some examples can incorporate more than one region producing an optical effect. |
| FILED | Thursday, September 02, 2021 |
| APPL NO | 17/446790 |
| CURRENT CPC | Books; Book Covers; Loose Leaves; Printed Matter Characterised by Identification or Security Features; Printed Matter of Special Format or Style Not Otherwise Provided For; Devices for Use Therewith and Not Otherwise Provided For; Movable-strip Writing or Reading Apparatus B42D 25/00 (20141001) B42D 25/21 (20141001) B42D 25/29 (20141001) B42D 25/30 (20141001) B42D 25/45 (20141001) B42D 25/324 (20141001) B42D 25/328 (20141001) B42D 25/342 (20141001) B42D 25/351 (20141001) B42D 25/355 (20141001) B42D 25/373 (20141001) B42D 25/378 (20141001) B42D 25/425 (20141001) B42D 25/435 (20141001) B42D 25/445 (20141001) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/55 (20130101) G01N 21/4738 (20130101) Optical Elements, Systems, or Apparatus G02B 3/005 (20130101) G02B 3/0056 (20130101) G02B 5/0278 (20130101) G02B 5/0284 (20130101) Handling of Coins or Valuable Papers, e.g Testing, Sorting by Denominations, Counting, Dispensing, Changing or Depositing G07D 7/128 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Office of the Director of National Intelligence (ODNI)
| US 20220236761 | MONROE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher MONROE (Ellicott City, Maryland); Jiehang ZHANG (College Park, Maryland); David WONG-CAMPOS (Hyattsville, Maryland); Antonios KYPRIANIDIS (Takoma, Maryland); Patrick Michael BECKER (College Park, Maryland) |
| ABSTRACT | The disclosure describes an adaptive and optimal imaging of individual quantum emitters within a lattice or optical field of view for quantum computing. Advanced image processing techniques are described to identify individual optically active quantum bits (qubits) with an imager. Images of individual and optically-resolved quantum emitters fluorescing as a lattice are decomposed and recognized based on fluorescence. Expected spatial distributions of the quantum emitters guides the processing, which uses adaptive fitting of peak distribution functions to determine the number of quantum emitters in real time. These techniques can be used for the loading process, where atoms or ions enter the trap one-by-one, for the identification of solid-state emitters, and for internal state-detection of the quantum emitters, where each emitter can be fluorescent or dark depending on its internal state. This latter application is relevant to efficient and fast detection of optically active qubits in quantum simulations and quantum computing. |
| FILED | Thursday, October 28, 2021 |
| APPL NO | 17/513496 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) B82Y 40/00 (20130101) Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 1/42 (20130101) G01J 2001/4247 (20130101) Optical Computing Devices; G06E 3/005 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/66977 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, July 28, 2022.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20220728.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page