FedInvent™ Patent Applications
Application Details for Thursday, August 04, 2022
This page was updated on Monday, August 08, 2022 at 08:23 AM GMT
Department of Health and Human Services (HHS)
| US 20220240499 | Li et al. |
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| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| INVENTOR(S) | Rui Li (Minneapolis, Minnesota); Allison Hubel (Minneapolis, Minnesota) |
| ABSTRACT | A cryopreservative composition includes a sugar component with a total concentration of sugar components in the composition of 300 mM or less; a sugar alcohol component, with a total concentration of sugar alcohol components in the composition of 2 M or less; and at least one of a polymer component and albumin, with the proviso that the composition includes less than a cryopreservative amount of dimethyl sulfoxide (DMSO). A method of cryopreserving a cell includes adding a cell to the cryopreservative composition; freezing the composition; storing the frozen composition; thawing the composition; removing the cell from the thawed composition; and culturing the cell under conditions effective for the cell to remain viable. The freezing may include cooling at a rate of 0.1° C./min to 5° C./min. The method may be performed without a washing step after thawing. |
| FILED | Friday, April 24, 2020 |
| APPL NO | 17/607695 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0221 (20130101) Original (OR) Class Preparations for Medical, Dental, or Toilet Purposes A61K 47/26 (20130101) Peptides C07K 14/76 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220240777 | DHALLA et al. |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Al-Hafeez DHALLA (Durham, North Carolina); Anthony KUO (Durham, North Carolina); Joseph IZATT (Durham, North Carolina) |
| ABSTRACT | Systems and method for multiplexing and alternating light of different wavelengths in an ophthalmoscope are disclosed herein. According to an aspect, an imaging system includes an illumination system configured to generate and output light that alternates between at least two different wavelengths. The imaging system includes a multiplexer configured to receive the output light and to multiplex the light of different wavelengths onto a single optical channel. Further, the imaging system includes a scanning laser ophthalmoscope probe configured to operatively receive the multiplexed light, to apply the multiplexed light to a subject for imaging, and to receive light returning from the subject for generating an image of the subject. |
| FILED | Friday, June 19, 2020 |
| APPL NO | 17/610535 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/07 (20130101) A61B 1/00172 (20130101) A61B 3/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220240782 | Wax et al. |
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| FUNDED BY |
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| APPLICANT(S) | DUKE UNIVERSITY (Durham, North Carolina); THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam Wax (Durham, North Carolina); Nicholas Shaheen (Durham, North Carolina); Kengyeh Chu (Durham, North Carolina); Derek Ho (Durham, North Carolina); Zachary Steelman (Durham, North Carolina) |
| ABSTRACT | Systems and methods for multi-modal imaging using an endoscope having an instrument channel, where the imaging is achieved without using the channel, are disclosed. The systems can include a multi-modal imaging paddle housing couple to a distal end of the endoscope. The housing can receive at least two imaging probes. The imaging probes can be an angle-resolved low-coherence interferometry probe (a/LCI) and an optical coherence tomography (OCT) probe. The housing can be scaled and positioned to be visible via the endoscope camera. The system and method can include locating the housing in a region of interest using the endoscope camera, acquiring OCT measurements to identify targets, and then acquiring a/LCI measurements at the identified targets. |
| FILED | Monday, January 31, 2022 |
| APPL NO | 17/589333 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/05 (20130101) A61B 1/07 (20130101) A61B 1/018 (20130101) A61B 1/0638 (20130101) A61B 5/0066 (20130101) Original (OR) Class A61B 10/04 (20130101) A61B 18/14 (20130101) A61B 2018/00577 (20130101) Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/02091 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220240783 | Fan et al. |
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| FUNDED BY |
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| APPLICANT(S) | SPECTRAL MD, INC. (Dallas, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wensheng Fan (Plano, Texas); John Michael DiMaio (Dallas, Texas); Jeffrey Thatcher (Irving, Texas) |
| ABSTRACT | Certain aspects relate to apparatuses and techniques for non-invasive and non-contact optical imaging that acquires a plurality of images corresponding to both different times and different frequencies. Additionally, alternatives described herein are used with a variety of tissue classification applications including assessing the presence and severity of tissue conditions, such as necrosis and small vessel disease, at a potential or determined amputation site. |
| FILED | Friday, March 02, 2018 |
| APPL NO | 16/489955 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0075 (20130101) Original (OR) Class A61B 5/0077 (20130101) A61B 5/441 (20130101) Image or Video Recognition or Understanding G06V 10/751 (20220101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220240845 | Holmes et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| INVENTOR(S) | Jeffrey W. Holmes (Charlottesville, Virginia); Colleen Witzenburg (Madison, Wisconsin); Pim Oomen (Charlottesville, Virginia); Kenneth C. Bilchick (Charlottesville, Virginia) |
| ABSTRACT | A method and system for rapidly predicting cardiac response to a heart condition and treatment strategy of a patient. Predictions are accomplished using a compartmental model that includes systemic and pulmonary circulations represented as a system of resistors and capacitors together with chambers of the heart represented as simple geometric shapes such as spheres or assemblies of spheres or other analytic equations that relate pressure and volume to stress and strain. The model is calibrated using disease-specific data sets for a specific heart condition. Simple geometry modeling allows for rapid use such that hemodynamic parameters may be tuned for optimal accuracy. Treatment strategies may be modified and re-simulated in real time if necessary to achieve a more optimal outcome and treatment. |
| FILED | Wednesday, March 11, 2020 |
| APPL NO | 17/436378 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4833 (20130101) Original (OR) Class A61B 5/7275 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/00 (20180101) G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220240899 | Trzasko et al. |
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| FUNDED BY |
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| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joshua D. Trzasko (Rochester, Minnesota); Shigao Chen (Rochester, Minnesota); Pengfei Song (Champaign, Illinois); Chengwu Huang (Rochester, Minnesota); Armando Manduca (Rochester, Minnesota); Matthew Lowerison (Champaign, Illinois) |
| ABSTRACT | Super-resolution ultrasound imaging of microvessels in a subject is described. Ultrasound data are acquired from a region-of-interest in a subject who has been administered a microbubble contrast agent. The ultrasound data are acquired while the microbubbles are moving through, or otherwise present in, the region-of-interest. Microbubble signals are isolated from the ultrasound data and are separated into subsets of data based on properties of the microbubbles, such as spatial-temporal hemodynamics. By localizing, tracking, and accumulating the microbubbles in each subset of data, super-resolution images of the microvessels can be generated for each subset, such that each of these images represents a sparse subset of microbubble signals. These images are combined to generate a super-resolution microvessel image. |
| FILED | Monday, June 15, 2020 |
| APPL NO | 17/618817 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/481 (20130101) A61B 8/488 (20130101) A61B 8/5223 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 7/20 (20130101) G06T 2207/10132 (20130101) G06T 2207/20084 (20130101) G06T 2207/30101 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220241076 | BRESSNER et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Jarred A. BRESSNER (Baltimore, Maryland); Mikhail OSANOV (Baltimore, Maryland); Adam LEVIN (Baltimore, Maryland) |
| ABSTRACT | An orthopaedic implant with a medical dosing capability is disclosed herein. The orthopaedic implant may include a structure configured to interact with a bone of the patient. The orthopaedic implant may include a reservoir associated with the structure to hold a medical substance for treating a health condition of the patient. The orthopaedic implant may include a dosing mechanism to release the medical substance to treat the health condition. |
| FILED | Wednesday, July 22, 2020 |
| APPL NO | 17/597215 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/28 (20130101) A61F 2/30 (20130101) Original (OR) Class A61F 2/4455 (20130101) A61F 2002/3068 (20130101) A61F 2002/3092 (20130101) A61F 2002/3093 (20130101) A61F 2002/30593 (20130101) A61F 2002/30677 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220241186 | PATEL et al. |
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| FUNDED BY |
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| APPLICANT(S) | Titan Pharmaceuticals, Inc. (South San Francisco, California) |
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| INVENTOR(S) | Rajesh A. PATEL (Redwood City, California); Louis R. BUCALO (Miami Beach, Florida) |
| ABSTRACT | The present invention provides compositions, methods, and kits for treatment of opiate addiction and pain. The invention provides a biocompatible nonerodible polymeric device which releases buprenorphine continuously with generally linear release kinetics for extended periods of time. Buprenorphine is released through pores that open to the surface of the polymeric matrix in which it is encapsulated. The device may be administered subcutaneously to an individual in need of continuous treatment with buprenorphine. |
| FILED | Friday, September 10, 2021 |
| APPL NO | 17/472502 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0024 (20130101) Original (OR) Class A61K 31/485 (20130101) A61K 31/4748 (20130101) A61K 47/32 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 31/16 (20130101) A61L 31/048 (20130101) A61L 31/125 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220241198 | Weitz et al. |
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| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David A. Weitz (Cambridge, Massachusetts); Joerg G. Werner (Medford, Massachusetts); Julie V. Brouchon (Cambridge, Massachusetts); John Heyman (Cambridge, Massachusetts); Brendan Deveney (Cambridge, Massachusetts) |
| ABSTRACT | The present invention generally relates to polymers and, in particular, to copolymers for stabilizing, e.g., emulsions or droplets. In certain aspects, the copolymers may comprise a relatively hydrophobic monomer and a relatively hydrophilic monomer polymerized together (e.g., randomly) to form the copolymer. Examples of hydrophobic monomers include methacrylates and vinylphenyls; examples of hydrophilic monomers include boronic acids or acid derivatives. Surprisingly, such random copolymers may act as surfactants, e.g., stabilizing droplets within the emulsion. In addition, in some cases, an interfacial film may be produced by exposing the copolymer to a complexing molecule, such as a polyol, that can complex with the copolymer to form the film. In some cases, the film may at least partially surround a droplet, and in certain embodiments, the film may be sufficiently sturdy such that the droplet can be removed from the emulsion. Other aspects include methods of making or using such copolymers (for example, for containing cells in droplets), kits involving such copolymers, or the like. |
| FILED | Friday, May 22, 2020 |
| APPL NO | 17/613023 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/107 (20130101) Original (OR) Class A61K 9/5026 (20130101) A61K 9/5089 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 220/14 (20130101) C08F 220/24 (20130101) C08F 220/56 (20130101) C08F 220/1802 (20200201) C08F 220/1806 (20200201) C08F 230/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220241214 | Salem et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Iowa Research Foundation (Iowa City, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aliasger K. Salem (Coralville, Iowa); Kimberly Leslie (Iowa City, Iowa); Xiangbing Meng (Iowa City, Iowa); Jianling Bi (Iowa City, Iowa); Kareem Ebeid (Iowa City, Iowa); Sudartip Areecheewakul (Iowa City, Iowa) |
| ABSTRACT | A nanoparticle comprising one or more quinonemethide triterpenoids or one or more inhibitors of metadherin, and methods of using the nanoparticles, are provided. |
| FILED | Friday, June 19, 2020 |
| APPL NO | 17/620391 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5153 (20130101) Original (OR) Class A61K 33/243 (20190101) A61K 45/06 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220241224 | Wan et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Derrick C. Wan (Stanford, California); Geoffrey C. Gurtner (Portola Valley, California); Michael T. Longaker (Atherton, California) |
| ABSTRACT | Methods of increasing perfusion and vascularity in irradiated tissue and of increasing retention of fat cells in a fat graft in irradiated tissue by applying an effective amount of DFO to the irradiated tissue at a treatment site. The DFO may be administered transdermally. |
| FILED | Thursday, April 14, 2022 |
| APPL NO | 17/721125 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/1075 (20130101) A61K 31/16 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220241267 | WINKLER et al. |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey WINKLER (Wynnewood, Pennsylvania); Ravi K. AMARAVADI (Media, Pennsylvania) |
| ABSTRACT | The disclosure is directed to bisaminoquinolines and bisaminoacridines as autophagy inhibitors for treating cancer and other disease states and conditions. |
| FILED | Sunday, May 24, 2020 |
| APPL NO | 17/613648 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/473 (20130101) Original (OR) Class A61K 31/4706 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 215/42 (20130101) C07D 219/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220241282 | Scarisbrick et al. |
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| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| INVENTOR(S) | Isobel A. Scarisbrick (Rochester, Minnesota); Hye-Sook Yoon (Rochester, Minnesota); Kristen L. Drucker (Oronoco, Minnesota) |
| ABSTRACT | Materials and methods for modulating protease activated receptor 1 (PAR1) activity to alter myelination are provided. |
| FILED | Tuesday, November 16, 2021 |
| APPL NO | 17/528103 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) Original (OR) Class A61K 31/7105 (20130101) A61K 35/12 (20130101) A61K 35/30 (20130101) A61K 48/00 (20130101) A61K 48/0058 (20130101) A61K 48/0066 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/00 (20130101) C12N 15/63 (20130101) C12N 15/85 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220241288 | Gallo et al. |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard L. Gallo (San Diego, California); Teruaki Nakatsuji (San Diego, California) |
| ABSTRACT | The disclosure provides for methods and compositions useful for treating infections, cancer and neoplastic diseases and disorders. |
| FILED | Tuesday, January 18, 2022 |
| APPL NO | 17/578130 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/0014 (20130101) A61K 31/52 (20130101) Original (OR) Class A61K 35/741 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/00 (20180101) A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220241299 | SLUSHER et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | BARBARA SLUSHER (KINGSVILLE, Maryland); DAVID VOLSKY (SCARSDALE, New York); MIKE NEDELCOVYCH (RICHMOND, Virginia); KRISTEN HOLLINGER (PARKTON, Maryland); ATSUSHI KAMIYA (PIKESVILLE, Maryland) |
| ABSTRACT | The disclosure provides compounds having formula (I): and the pharmaceutically acceptable salts thereof, wherein R1, R2, R2′, and X are as defined as set forth in the specification, for use in treating cognitive deficits and/or psychiatric disorders, such as those associated with neurological or neurodegenerative disorders, psychiatric or mood disorders, and HIV-associated neurocognitive disorders (HAND). Compounds having formula (I) are prodrugs that release glutamine analogs, e.g., 6-diazo-5-oxo-L-norleucine (DON). |
| FILED | Friday, September 03, 2021 |
| APPL NO | 17/465990 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/42 (20130101) A61K 31/198 (20130101) A61K 31/223 (20130101) A61K 31/655 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220241300 | Aldrich et al. |
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| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Courtney C. Aldrich (Minneapolis, Minnesota); Subhankar Panda (St. Paul, Minnesota); Tej Poudel (Minneapolis, Minnesota) |
| ABSTRACT | The disclosure relates to compounds of the formula (I) and (II), pharmaceutical compositions comprising one or more such compounds, and methods for treating pulmonary infections with one or more such compounds (e.g., treating SARS-CoV, MERS-CoV or SARS-CoV-2). |
| FILED | Wednesday, January 19, 2022 |
| APPL NO | 17/579271 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/675 (20130101) Original (OR) Class A61K 31/706 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220241302 | Voelker et al. |
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| FUNDED BY |
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| APPLICANT(S) | National Jewish Health (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dennis R. Voelker (Greenwood Village, Colorado); Mari Numata-Nakamura (Kanagawa, Japan) |
| ABSTRACT | The invention generally relates to methods to inhibit inflammation or pathogen infection by administering at least one anionic lipid or compositions comprising at least one anionic lipid to an individual. The invention also relates to methods to prevent or inhibit respiratory syncytial virus (RSV) infection by administering at least one anionic lipid or compositions comprising at least one anionic lipid to an individual. The invention further relates to compositions comprising randomly mixed surfactant lipids and methods to produce the compositions. |
| FILED | Monday, September 13, 2021 |
| APPL NO | 17/473216 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/007 (20130101) A61K 9/127 (20130101) A61K 31/66 (20130101) A61K 31/683 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220241303 | SELKER |
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| FUNDED BY |
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| APPLICANT(S) | Tufts Medical Center, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Harry SELKER (Wellesley, Massachusetts) |
| ABSTRACT | The invention provides methods for treating and preventing acute coronary syndromes (ACS). The methods involve initiation of the administration of glucose-insulin-potassium (GIK) soon (e.g., within 3 hours) after the onset of ACS symptoms. |
| FILED | Thursday, March 12, 2020 |
| APPL NO | 17/438712 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7004 (20130101) Original (OR) Class A61K 33/14 (20130101) A61K 38/28 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220241309 | Dickey et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of South Florida (Tampa, Florida); University of Kansas (Lawrence, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chad Dickey (Tampa, Florida); Lindsey Shelton (Tampa, Florida); Brian Blagg (Lawrence, Kansas); John Koren (Tampa, Florida); Laura Jenelle Blair (Tampa, Florida) |
| ABSTRACT | Disclosed herein are compounds and methods for inhibiting Aha1 for the treatment of tauopathies and neurodegenerative diseases. The Aha1 inhibitor may reduce the interaction between Aha1 and Hsp90. The Aha1 inhibitor may reduce aggregation of tau protein. The Aha1 inhibitor may include a compound selected from KU-177, KU-174, and KU-308. |
| FILED | Friday, April 15, 2022 |
| APPL NO | 17/722011 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/366 (20130101) A61K 31/7048 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220241314 | Gale, JR. et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Michael J. Gale, JR. (Seattle, Washington); Sooyoung Lee (Seattle, Washington) |
| ABSTRACT | The disclosure provides compositions and methods for suppressing Hepatitis B virus (HBV) in an infected cell. Exemplary methods comprise contacting the infected cell with one or more agents that induce interferon regulatory factor 3 (IRF3) activation in the infected cell. In some embodiments, the one or more agents comprises pathogen-associated molecular pattern (PAMP)-containing nucleic acid molecule, a small molecule agent (e.g., a benzothiazol-derivative molecule), or a combination thereof. In some embodiments, the method further comprises contacting the infected cell with a NRTI. The method can be an in vivo method of treating a subject with HBV infection, comprising administering therapeutically relevant amounts of one or more agents formulated in one or more therapeutically effect compositions. Exemplary compositions are formulated to treat a hepatitis B virus (HBV) infection in a subject, comprising: a RIG-I agonist, a vehicle for intracellular delivery, and a pharmaceutically acceptable carrier. |
| FILED | Thursday, March 31, 2022 |
| APPL NO | 17/710783 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/428 (20130101) A61K 31/506 (20130101) A61K 31/522 (20130101) A61K 31/675 (20130101) A61K 31/7072 (20130101) A61K 31/7088 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220241317 | Duvall et al. |
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| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Craig L. Duvall (Nashville, Tennessee); Samantha M. Sarett (Nashville, Tennessee); Thomas A. Werfel (Nashville, Tennessee) |
| ABSTRACT | Provided herein are compounds and methods for gene silencing. The compound includes a RNA directly conjugated to an albumin-binding group. The method includes administering a compound comprising a RNA directly conjugated to an albumin-binding group to a subject in need thereof. |
| FILED | Tuesday, September 14, 2021 |
| APPL NO | 17/474765 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/7105 (20130101) Original (OR) Class A61K 47/543 (20170801) Peptides C07K 14/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) C12N 2310/14 (20130101) C12N 2310/141 (20130101) C12N 2310/3515 (20130101) C12N 2320/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220241335 | LUCA et al. |
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| FUNDED BY |
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| APPLICANT(S) | H. LEE MOFFITT CANCER CENTER AND RESEARCH INST5ITUTE, INC. (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vincent LUCA (Tampa, Florida); Paulo RODRIGUEZ (Tampa, Florida); David GONZALEZ-PEREZ (Tampa, Florida) |
| ABSTRACT | Disclosed are compositions and methods for engineered Notch ligands for activating Notch signaling, enhancing eh efficacy of adoptive T cell immunotherapy, making a T cell resistant to tumor suppression, and/or treating a cancer. In one aspect, disclosed herein are methods of activating Notch signaling comprising contacting T cells (such as, for example CD8+ T cells, CD4+ T cells, chimeric antigen receptor 15 (CAR) T cells, tumor infiltrating lymphocytes (TILs), and/or marrow infiltrating lymphocytes (MILS)) with a chemically designed Notch ligand. |
| FILED | Monday, July 13, 2020 |
| APPL NO | 17/626315 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 38/1774 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0638 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220241337 | Mintz |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of NewYork (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Akiva Mintz (Paramus, New Jersey) |
| ABSTRACT | Methods of preparing tissues for treatment or imaging and for treating or imaging tissues in a subject in which therapeutic or imageable molecules operably associated with a heat-inducible promoter and an HSP-inducing molecule are administered to the subject. |
| FILED | Friday, February 21, 2020 |
| APPL NO | 17/432704 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/495 (20130101) A61K 35/28 (20130101) Original (OR) Class A61K 48/0025 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220241342 | Woods et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ossium Health, Inc. (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Erik J. Woods (Carmel, Indiana); Brian H. Johnstone (Fishers, Indiana); Dongsheng Gu (Indianapolis, Indiana); Aubrey Marie Sherry (Carmel, Indiana); Kelsey Gwen Musall (Avon, Indiana); Megan Sykes (New York, New York); Tomoaki Kato (New York, New York) |
| ABSTRACT | Described herein are methods of cell therapies. Also described herein are methods of generating donor derived T cells in an organ transplant recipient, by administering bone marrow stem cells to the organ transplant recipient about 1 to about 30 days after the organ transplant recipient receives one or more organ transplants. |
| FILED | Wednesday, March 16, 2022 |
| APPL NO | 17/696779 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/436 (20130101) A61K 35/17 (20130101) A61K 35/28 (20130101) Original (OR) Class A61K 38/1774 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/06 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 5/0647 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220241355 | Balani et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Forsyth Dental Infirmary for Children (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pooja Balani (Melrose, Massachusetts); Felicitas Bidlack (Somerville, Massachusetts); Xuesong He (Cypress, California); Megan Pugach-Gordon (Medford, Massachusetts); Wenyuan Shi (Winchester, Massachusetts); Jacqueline Starr (Lexington, Massachusetts); Daniel Ferrer (Boston, Massachusetts) |
| ABSTRACT | Provided herein are methods and compositions related to bacteria of genus Rothia useful as therapeutic agents for dental caries. |
| FILED | Thursday, January 13, 2022 |
| APPL NO | 17/575160 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 6/00 (20130101) A61K 35/747 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220241395 | Amanna et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Najít Technologies, Inc. (Beaverton, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ian J. Amanna (Hillsboro, Oregon); Elizabeth A. Poore (Portland, Oregon) |
| ABSTRACT | Provided are surprisingly effective methods for inactivating pathogens, and for producing highly immunogenic vaccine compositions containing an inactivated pathogen rendered noninfectious by exposure to a Fenton reagent, or by exposure to a Fenton reagent or a component thereof in combination with a methisazone reagent selected from the group consisting of methisazone, methisazone analogs, functional group(s)/substructure(s) of methisazone, and combinations thereof. The methods efficiently inactivate pathogens, while substantially retaining pathogen antigenicity and/or immunogenicity, and are suitable for inactivating pathogens, or for the preparation of vaccines for a wide variety of pathogens with genomes comprising RNA or DNA, including viruses and bacteria. Also provided are highly immunogenic inactivated vaccine compositions prepared by using any of the disclosed methods, and methods for eliciting an immune response in a subject by administering such vaccine compositions. |
| FILED | Friday, October 08, 2021 |
| APPL NO | 17/497810 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 33/40 (20130101) A61K 39/02 (20130101) A61K 39/12 (20130101) A61K 39/105 (20130101) A61K 39/145 (20130101) Original (OR) Class A61K 39/275 (20130101) A61K 39/0283 (20130101) A61K 2039/521 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) A61P 31/16 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220241396 | Kawaoka et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (WARF) (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yoshihiro Kawaoka (Middleton, Wisconsin); Yuri Furusawa (Tokyo, Japan) |
| ABSTRACT | The disclosure provides for an isolated recombinant influenza virus having at least one of: a PB2 viral segment encoding PB2 with residue at position 540 that is not asparagine or a residue at position 712 that is not glutamic acid, a PA viral segment encoding PA with a residue at position 180 that is not glutamine or a residue at position 200 that is not threonine, or a PB1 viral segment encoding PB1 with a residue at position 149 that is not valine, a residue at position 634 that is not glutamic acid or a residue at position 635 that is not aspartic acid, or any combination thereof, and methods of making and using the virus. |
| FILED | Wednesday, January 19, 2022 |
| APPL NO | 17/578939 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/145 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220241399 | Lusso et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Moderna TX, Inc. (Cambridge, Massachusetts); The United States of America, as represented by the Department of Health and Human Services (Rockville, Maryland) |
| ASSIGNEE(S) | Moderna TX, Inc. (Cambridge, Massachusetts); The United States of America, as represented by the Department of Health and Human Services (Rockville, Maryland) |
| INVENTOR(S) | Paolo Lusso (Rockville, Maryland); Peng Zhang (Rockville, Maryland); Elisabeth Narayanan (Cambridge, Massachusetts); Sayda Mahgoub Elbashir (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein are methods and compositions for inducing in a subject abroad neutralizing antibody response to human immunodeficiency virus (HIV) infection. |
| FILED | Friday, March 13, 2020 |
| APPL NO | 17/439198 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/21 (20130101) Original (OR) Class A61K 39/39 (20130101) A61K 2039/6018 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220241401 | Kousoulas |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| ASSIGNEE(S) | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| INVENTOR(S) | Konstantin G. Kousoulas (Baton Rouge, Louisiana) |
| ABSTRACT | The present invention provides vaccines for treating or preventing a herpes simplex virus infection and methods of using and making the vaccine. Further provided are recombinant herpes simplex virus genomes, recombinant viruses, and immunogenic compositions. |
| FILED | Tuesday, December 14, 2021 |
| APPL NO | 17/550272 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/245 (20130101) Original (OR) Class A61K 2039/5254 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2710/16622 (20130101) C12N 2710/16634 (20130101) C12N 2710/16662 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220241403 | CLARK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington); ABACUS BIOSCIENCE, INC. (Sammamish, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edward A. CLARK (Seattle, Washington); Deborah L. FULLER (Seattle, Washington); Che-Leung LAW (Seattle, Washington); Amanda MAK (Seattle, Washington) |
| ABSTRACT | Provided herein are compositions of CD1280 binding proteins and a Hepatitis B virus core antigen (HBcAg) and/or a Hepatitis B virus E antigen (HBeAg), or antigenic fragments or mutants thereof, attached to the CD180 binding protein, and methods for using the compositions to treat or limit the development of hepatitis-B virus (HBV)-related disorders. |
| FILED | Friday, April 15, 2022 |
| APPL NO | 17/721554 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) A61K 39/292 (20130101) Original (OR) Class A61K 39/001129 (20180801) Peptides C07K 16/2896 (20130101) C07K 2317/56 (20130101) C07K 2317/524 (20130101) C07K 2317/526 (20130101) C07K 2317/622 (20130101) C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2730/10134 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220241410 | Bazin-Lee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE UNIVERSITY OF MONTANA (Missoula, Montana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Helene Bazin-Lee (Stevensville, Montana); David Burkhart (Missoula, Montana); Jay Evans (Corvallis, Montana) |
| ABSTRACT | Lipidated oxoadenines of formula (I) are TLR7/8 receptor ligands useful for modulating immune responses. The compounds may have therapeutic application in the treatment of cancer, infectious diseases, allergy, or autoimmnune disorders. |
| FILED | Friday, May 22, 2020 |
| APPL NO | 17/613414 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) Original (OR) Class A61K 2039/55511 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/65616 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220241418 | SADDOW et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Stephen Edward SADDOW (Land O Lakes, Florida); Peter L. CHOYKE (Rockville, Maryland); UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen Edward SADDOW (Land O Lakes, Florida); Peter L. CHOYKE (Rockville, Maryland); Marco Vittorio NARDI (Levico Terme, Italy) |
| ABSTRACT | Methods for the treatment of cancers, in particular deep-tissue cancers, using x-ray induced near-infrared photoimmunotherapy are described herein. |
| FILED | Wednesday, June 10, 2020 |
| APPL NO | 17/617652 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 41/0038 (20130101) A61K 41/0057 (20130101) Original (OR) Class A61K 47/6851 (20170801) A61K 47/6929 (20170801) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/10 (20130101) A61N 5/062 (20130101) A61N 2005/0659 (20130101) A61N 2005/1098 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220241439 | ZHENG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jie ZHENG (Plano, Texas); Xingya JIANG (Richardson, Texas) |
| ABSTRACT | A biothiol-activatable composition is disclosed that is configured to dissociate in the presence of a concentration of biomolecules that are excreted normally by a liver of a living subject comprising a noble metal nanoparticle, a reporter molecule, a linker molecule that is conjugated to the noble metal nanoparticle and to the reporter molecule, but displaceable in the presence of the biomolecules, and wherein the reporter molecule is released in the presence of the biomolecules. The noble nanoparticle is preferably a gold nanoparticle; the reporter molecule preferably comprises at least one of a fluorescent dye molecule, a radioactive molecule or an MRI agent and the linker molecule is preferably a thiol molecule displaceable by biothiols in the liver. In another aspect, the reporter molecule dissociates from the composition in the presence of a concentration of glutathione similar to what is found in liver sinusoids of a normally functioning liver. |
| FILED | Wednesday, June 17, 2020 |
| APPL NO | 17/620312 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5115 (20130101) A61K 49/0034 (20130101) A61K 49/0093 (20130101) Original (OR) Class A61K 49/186 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/542 (20130101) G01N 33/6815 (20130101) G01N 33/54353 (20130101) G01N 2800/085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220241570 | Falo, JR. et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Louis D. Falo, JR. (Wexford, Pennsylvania); Emrullah Korkmaz (Pittsburgh, Pennsylvania) |
| ABSTRACT | The disclosed methods relate to forming microneedle arrays from a production mold that comprises a flexible mold material. The disclosed methods can be used to reproducibly manufacture undercut dissolvable and coated microneedle arrays with various shapes and structures. |
| FILED | Friday, May 15, 2020 |
| APPL NO | 17/611486 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 37/0015 (20130101) Original (OR) Class A61M 2037/0023 (20130101) A61M 2037/0053 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 33/50 (20130101) B29C 33/3835 (20130101) B29C 33/3842 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2105/0035 (20130101) B29K 2995/006 (20130101) B29K 2995/0062 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220241614 | Wu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DUKE UNIVERSITY (Durham, North Carolina) |
| ASSIGNEE(S) | The University of North Carolina at Charlotte (Charlotte, North Carolina) |
| INVENTOR(S) | Qingrong Wu (Durham, North Carolina); Yaorong Ge (Durham, North Carolina); Fang-Fang Yin (Durham, North Carolina); Qiuwen Wu (Durham, North Carolina); Chunhao Wang (Durham, North Carolina); Yang Sheng (Durham, North Carolina); Xinyi Li (Durham, North Carolina); Wentao Wang (Durham, North Carolina) |
| ABSTRACT | A radiation treatment planning system can include a machine learning system that receives patient data, including an image scan (e.g., CT scan) and contour(s), a physician prescription, including planning target and dose, and device (radiation beam) data and outputs predicted fluence maps. The machine learning system includes at least two stages, where a stage of the at least two stages includes converting image scans from the patient data to projection images. A treatment planning system can receive the predicted fluence maps and generates treatment plans without performing inverse optimization. |
| FILED | Tuesday, February 01, 2022 |
| APPL NO | 17/590711 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/1039 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220242848 | De Vivo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Fondazione Istituto Italiano Di Tecnologia (Genova, Italy); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | Fondazione Istituto Italiano Di Tecnologia (Genova, Italy); The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Marco De Vivo (Genova, Italy); Anand Ganesan (Irvine, California); Jose Antonio Ortega Martinez (Genova, Italy); Sohail Jahid (Irvine, California) |
| ABSTRACT | The present invention relates to compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof: It further discloses a pharmaceutical composition comprising the compounds of Formula (I) and their uses, in particular in the treatment of diseases or disorders associated to increased relative to physiological or desired RhoJ/Cdc42 levels of expression or function. |
| FILED | Tuesday, November 23, 2021 |
| APPL NO | 17/456346 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Heterocyclic Compounds C07D 401/14 (20130101) Original (OR) Class C07D 405/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220242849 | Lee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Taekyu Lee (Brentwood, Tennessee); Changho Han (Nashville, Tennessee); Jonathan J. Mills (Nashville, Tennessee); Kevin B. Teuscher (Nashville, Tennessee); Jianhua Tian (Montgomery, Maryland); Kenneth M. Meyers (Nashville, Tennessee); Somenath Chowdhury (Nashville, Tennessee); Stephen W. Fesik (Nashville, Tennessee) |
| ABSTRACT | Quinazolin-4(3H)-one, 2,3-dihydroquinazolin-4(1H)-one, 3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one, and 3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione compounds and derivatives inhibit WDR5 and associated protein-protein interactions, and the compounds and their pharmaceutical compositions are useful for treating disorders and conditions in a subject, such as cancer cell proliferation. |
| FILED | Thursday, June 04, 2020 |
| APPL NO | 17/613717 |
| CURRENT CPC | Heterocyclic Compounds C07D 401/14 (20130101) Original (OR) Class C07D 403/06 (20130101) C07D 403/12 (20130101) C07D 403/14 (20130101) C07D 413/06 (20130101) C07D 413/12 (20130101) C07D 413/14 (20130101) C07D 417/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220242854 | Brabander et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Jef De Brabander (Dallas, Texas); Qiren Liang (Dallas, Texas); Beth Levine (Dallas, Texas); Wei-Chung Chiang (Dallas, Texas) |
| ABSTRACT | Small molecule disruptors of Beclin-1/Bc1-2 protein-protein interactions induce autophagy and hence are useful for treating a variety of indications where stimulation of autophagy is therapeutically useful, including cancer, infection immunity, neurodegeneration, longevity. |
| FILED | Tuesday, April 05, 2022 |
| APPL NO | 17/714131 |
| CURRENT CPC | Heterocyclic Compounds C07D 231/06 (20130101) C07D 231/12 (20130101) C07D 401/04 (20130101) C07D 403/04 (20130101) C07D 405/04 (20130101) Original (OR) Class C07D 405/06 (20130101) C07D 405/12 (20130101) C07D 405/14 (20130101) C07D 409/04 (20130101) C07D 413/04 (20130101) C07D 413/10 (20130101) C07D 417/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220242865 | Gray et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Nathanael S. Gray (Stanford, California); Tinghu Zhang (Brookline, Massachusetts); Nicholas Paul Kwiatkowski (Brookline, Massachusetts) |
| ABSTRACT | The present invention provides novel compounds of Formula (I), (II), or (III), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating and/or preventing proliferative diseases (e.g., cancers (e.g., leukemia, acute lymphoblastic leukemia, lymphoma, Burkitt's lymphoma, melanoma, multiple myeloma, breast cancer, Ewing's sarcoma, osteosarcoma, brain cancer, ovarian cancer, neuroblastoma, lung cancer, colorectal cancer), benign neoplasms, diseases associated with angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of a kinase, such as a cyclin-dependent kinase (CDK) (e.g., CDK7, CDK12, or CDK13), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject. |
| FILED | Thursday, April 07, 2022 |
| APPL NO | 17/715874 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 43/00 (20180101) Heterocyclic Compounds C07D 473/16 (20130101) Original (OR) Class C07D 473/34 (20130101) C07D 487/04 (20130101) Peptides C07K 14/4738 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220242867 | Levy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts); Children's Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts); Children's Medical Center Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Ofer Levy (Cambridge, Massachusetts); David J. Dowling (Brighton, Massachusetts); Francesco Borriello (Jamaica Plain, Massachusetts); David A. Scott (Newton, Massachusetts); Spencer E. Brightman (San Diego, California); Frederic Feru (Boston, Massachusetts) |
| ABSTRACT | The present disclosure provides compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. The compounds described herein are used as enhancers and/or modifiers of an immune response (e.g., innate and/or adaptive immune response), and are useful in treating and/or preventing a disease, as adjuvants in a vaccine for the disease, (e.g., proliferative disease, inflammatory disease, autoimmune disease, infectious disease, or chronic disease), or as stand alone anti-infective or immune response modifying agents. Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a compound described herein. |
| FILED | Wednesday, November 14, 2018 |
| APPL NO | 16/764171 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) A61K 45/06 (20130101) Heterocyclic Compounds C07D 487/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220242872 | Qi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| INVENTOR(S) | Jun Qi (Sharon, Massachusetts); Eric S. Fischer (Chestnut Hill, Massachusetts); Paul M. Park (Waltham, Massachusetts); Chengkui Pei (Brighton, Massachusetts); Radoslaw Piotr Nowak (Boston, Massachusetts) |
| ABSTRACT | Provided herein are compounds of Formulae (I) and (II), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. The compounds described herein bind an E3 ubiquitin ligase (e.g., Cereblon) and induce degradation of a transcription factor (e.g., IKZF1, IKZF3). Also provided are pharmaceutical compositions comprising the compounds, and methods of treating and/or preventing diseases (e.g., proliferative diseases (e.g., cancers (e.g., carcinoma); leukemia, lung cancer, breast cancer, liver cancer, pancreatic cancer, gastric cancer, ovarian cancer, colon cancer, colorectal cancer, multiple myeloma, and acute myeloid leukemia (AML))). Further provided are methods of inducing the degradation of a transcription factor (e.g., IKZF1, IKZF3) by administering a compound or composition described herein to a subject and/or to a biological sample (e.g., cell or tissue). |
| FILED | Tuesday, June 23, 2020 |
| APPL NO | 17/620394 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 35/02 (20180101) Heterocyclic Compounds C07D 401/04 (20130101) C07D 487/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220242933 | Roopenian et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE JACKSON LABORATORY (Bar Harbor, Maine) |
| ASSIGNEE(S) | THE JACKSON LABORATORY (Bar Harbor, Maine) |
| INVENTOR(S) | Derry Roopenian (Salisbury Cove, Maine); Gregory Christianson (Seal Cove, Maine) |
| ABSTRACT | In certain embodiments, this present invention provides antibodies and Fc fusion proteins with enhanced pharmacokinetics, such as biotinylated antibodies or biotinylated Fc fusion polypeptides. |
| FILED | Friday, September 03, 2021 |
| APPL NO | 17/466247 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/557 (20170801) A61K 47/6835 (20170801) A61K 2039/505 (20130101) Peptides C07K 16/00 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/72 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220242935 | Ellebedy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri); Icahn School of Medicine at Mount Sinai (New York, New York); The Scripps Research Institute (La Jolla, California) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri); Icahn School of Medicine at Mount Sinai (New York, New York); The Scripps Research Institute (La Jolla, California) |
| INVENTOR(S) | Ali Ellebedy (St. Louis, Missouri); Florian Krammer (New York, New York); Ian Wilson (La Jolla, California) |
| ABSTRACT | The present invention relates to antibodies against influenza neuraminidase, compositions containing the antibodies and methods of using the antibodies. |
| FILED | Friday, May 29, 2020 |
| APPL NO | 17/615309 |
| CURRENT CPC | Peptides C07K 16/40 (20130101) C07K 16/1018 (20130101) Original (OR) Class C07K 2317/34 (20130101) C07K 2317/52 (20130101) C07K 2317/55 (20130101) C07K 2317/76 (20130101) C07K 2317/565 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220242947 | North et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Woomera Therapeutics (Lebanon, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William G. North (Hanover, New Hampshire); Roy H.L. Pang (Etna, New Hampshire) |
| ABSTRACT | Provided herein are pro-VP antagonists, such as antibodies and antigen-binding portions thereof specific for pro-VP, for identifying and targeting expressing cancer cells. Applicants additionally provide methods of using said compositions, for example to image cancer cells in vivo and in biological samples. The compositions may also be used for treating patients suffering from a provasopressin-expressing cancer. Provasopressin-expressing cancers include neuroendocrine cancer, pancreatic cancer, and prostate cancer. |
| FILED | Thursday, September 19, 2019 |
| APPL NO | 16/575911 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/137 (20130101) A61K 38/10 (20130101) A61K 39/3955 (20130101) A61K 39/39558 (20130101) A61K 45/06 (20130101) A61K 47/6847 (20170801) A61K 49/00 (20130101) A61K 51/1024 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/26 (20130101) Original (OR) Class C07K 16/303 (20130101) C07K 16/3015 (20130101) C07K 16/3023 (20130101) C07K 16/3069 (20130101) C07K 2317/77 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57415 (20130101) G01N 33/57423 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220242955 | Knoechel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts); THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts); THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts) |
| INVENTOR(S) | Birgit Knoechel (Brookline, Massachusetts); Jens G. Lohr (Brookline, Massachusetts); Praveen Anand (Allston, Massachusetts); Amy Guillaumet-Adkins (Allston, Massachusetts); Jon Aster (Lexington, Massachusetts) |
| ABSTRACT | The present invention relates to compositions and methods for treating early T-cell precursor acute lymphoblastic leukemia (ETP T-ALL). |
| FILED | Friday, July 10, 2020 |
| APPL NO | 17/622507 |
| CURRENT CPC | Peptides C07K 16/2851 (20130101) Original (OR) Class C07K 2317/76 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57426 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220242964 | Braciale et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas J. Braciale (Charlottesville, Virginia); Taeg S. Kim (Charlottesville, Virginia) |
| ABSTRACT | The present application discloses a previously unknown function of CD24 expressed on a subset of dendritic cells. The invention encompasses regulating CD24 on these cells to regulate erythropoiesis, induce EPO production and levels, increase RBC levels, and to treat, for example, stress-mediated erythropoiesis. The compositions and methods of the invention are useful, for example, in treating anemia. |
| FILED | Monday, September 13, 2021 |
| APPL NO | 17/473459 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/3955 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/2896 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220243157 | Lin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Hang Lin (Pittsburgh, Pennsylvania); Rocky Sung Chi Tuan (Pittsburgh, Pennsylvania); Michael Seth Gold (Oakmont, Pennsylvania) |
| ABSTRACT | Disclosed herein are various bioreactor devices that mimic the mammalian joint. The bioreactor device can include a series of bioreactor chambers that contain different components of the joint, such as bone, cartilage, synovium, nerve and ligament. At least two different nutrient fluid circulation systems connect subsets of the bioreactor chambers to differentially supply nutrient fluids at concentrations optimized for the tissue that the fluid nourishes. For example, relatively hypoxic fluid can be supplied to synovium and cartilage to mimic oxygenation in the joint compartment, but normoxic fluid can be supplied to the bone and other components that have an arterial supply that provides higher oxygen concentrations. One or more or all of the bioreactor chambers can be supplied with separate inlets through which perturbation agents (such as drugs or other agents) can be introduced to model the effect of the perturbations on different components of the system. In some cases, the system can include a well plate having a plurality of wells and a bioreactor situated in each well of the well plate. |
| FILED | Tuesday, April 19, 2022 |
| APPL NO | 17/724372 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/50 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) Original (OR) Class C12M 35/08 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0697 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220243173 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Glast (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mingliang Zhang (San Francisco, California); Sheng Ding (Orinda, California) |
| ABSTRACT | Compositions and methods are described herein for chemically inducing cells to change their differentiation state and become neuronal cells. |
| FILED | Friday, January 28, 2022 |
| APPL NO | 17/587116 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/30 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0619 (20130101) Original (OR) Class C12N 2501/15 (20130101) C12N 2501/065 (20130101) C12N 2501/115 (20130101) C12N 2501/155 (20130101) C12N 2501/385 (20130101) C12N 2501/415 (20130101) C12N 2501/999 (20130101) C12N 2506/1307 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220243174 | KIM |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The McLean Hospital Corporation (Belmont, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kwang-Soo KIM (Lexington, Massachusetts) |
| ABSTRACT | Methods for generating midbrain dopamine (mDA) neuronal progenitor cells useful for autologous cell therapy in Parkinson's Disease, compositions comprising the cells, and methods of use thereof. |
| FILED | Thursday, May 21, 2020 |
| APPL NO | 17/613586 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/30 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/16 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0619 (20130101) Original (OR) Class C12N 15/85 (20130101) C12N 2501/01 (20130101) C12N 2501/13 (20130101) C12N 2501/15 (20130101) C12N 2501/119 (20130101) C12N 2506/45 (20130101) C12N 2800/108 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220243176 | LINDNER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE PENN STATE RESEARCH FOUNDATION (University, Pennsylvania); UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott Eugene LINDNER (State College, Pennsylvania); Susan HAFENSTEIN (Petersburg, Pennsylvania); Noah BUTLER (Iowa City, Iowa) |
| ABSTRACT | Provided are compositions and methods for use in isolating cells responsive to a target protein by first contacting a collection of isolated cells in an in vitro sample to a complex and then isolating the complex. The complex is formed from a target protein with a capture tag coupled to a multimeric protein structure of at least two self-assembled copies of a monomeric protein substructure fused with a capture sequence. |
| FILED | Wednesday, May 20, 2020 |
| APPL NO | 17/614711 |
| CURRENT CPC | Magnetic or Electrostatic Separation of Solid Materials From Solid Materials or Fluids; Separation by High-voltage Electric Fields B03C 1/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0634 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220243178 | CLAUSSNITZER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BROAD INSTITUTE, INC. (CAMBRIDGE, Massachusetts); BETH ISRAEL DEACONESS MEDICAL CENTER (BOSTON, Massachusetts); HEBREW SENIORLIFE, INC. (BOSTON, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Melina CLAUSSNITZER (Boston, Massachusetts); Nasa SINNOTT-ARMSTRONG (Cambridge, Massachusetts); Isabel SOUSA (Cambridge, Massachusetts); Samantha LABER (Cambridge, Massachusetts); Douglas KIEL (Boston, Massachusetts); Eric S. LANDER (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein is a method for controlling a rate of fatty acid oxidation in mesenchymal cells, comprising modulating the expression or activity of ADCY5. The rate of fatty acid oxidation may be decreased by reducing the expression or activity of ADCY5. The rate of fatty acid oxidation may be increased by increasing the expression or activity of ADCY5. In some embodiments, the mesenchymal cell may be a mesenchymal stem cell, an adipocyte, an osteoblast, a chondrocyte, or a myocyte. In some embodiments, controlling the rate of fatty acid oxidation in mesenchymal stem cells comprises inhibiting fatty acid oxidation. In some embodiments, inhibiting fatty acid oxidation prevents development of Type 2 Diabetes (T2D). In some embodiments, controlling the rate of fatty acid oxidation in mesenchymal stem cells may comprise increasing the rate of fatty acid oxidation. Increasing the rate of fatty acid oxidation may promote bone formation. |
| FILED | Friday, May 29, 2020 |
| APPL NO | 17/615540 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/32 (20130101) A61K 35/35 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/00 (20180101) A61P 19/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0653 (20130101) Original (OR) Class C12N 5/0654 (20130101) C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6851 (20130101) C12Q 1/6883 (20130101) C12Q 2600/156 (20130101) C12Q 2600/172 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220243179 | Helmrath et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CHILDREN'S HOSPITAL MEDICAL CENTER (Cincinnati, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael A. Helmrath (Cincinatti, Ohio); Maxime Mickael Mahe (Cincinatti, Ohio); Holly M. Poling (Cincinatti, Ohio) |
| ABSTRACT | Disclosed herein are organoid compositions that are manipulated to form shaped or elongated morphologies that more closely resemble native organ structures. These shaped organoids are advantageous for purposes such as studying organellar organization and for transplants compared to unformed organoids. Also disclosed herein are methods of producing said shaped or elongated organoid compositions. |
| FILED | Friday, May 29, 2020 |
| APPL NO | 17/595494 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/38 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0062 (20130101) C12N 5/0619 (20130101) C12N 5/0656 (20130101) C12N 5/0679 (20130101) C12N 5/0697 (20130101) Original (OR) Class C12N 2506/45 (20130101) C12N 2513/00 (20130101) C12N 2527/00 (20130101) C12N 2535/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220243198 | Glenn et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey S. Glenn (Palo Alto, California); Rachel Hagey Saluti (Stanford, California); Edward A. Pham (Palo Alto, California) |
| ABSTRACT | Methods of inhibiting influenza A virus in a sample are provided. Aspects of the methods include contacting a sample comprising viral RNA (vRNA) having a PSL2 motif with an effective amount of an agent that specifically binds the PSL2 motif to inhibit the influenza A virus. Also provided are methods of treating or preventing influenza A virus infection in a subject. Also provided are methods for screening a candidate agent for the ability to inhibit influenza A virus in a cell, the method comprising: contacting a sample with a candidate agent; and determining whether the candidate agent specifically binds to the PSL2 motif of vRNA. Also provided are compounds and pharmaceutical compositions comprising an oligonucleotide sequence complementary to a PB2 vRNA region that find use in the subject methods. |
| FILED | Friday, April 08, 2022 |
| APPL NO | 17/716497 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) Original (OR) Class C12N 2310/31 (20130101) C12N 2310/322 (20130101) C12N 2310/531 (20130101) C12N 2310/3231 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220243211 | Gupta et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anisha Gupta (Glastonbury, Connecticut); Peter Glazer (Guilford, Connecticut); Marie Egan (Madison, Connecticut); W. Mark Saltzman (New Haven, Connecticut); Christina Barone (New Haven, Connecticut) |
| ABSTRACT | Triplex-forming peptide nucleic acid (PNA) oligomers having a γ-substitution in one or more residues of the Hoosteen binding segment are provided. γPNA-containing triplex-forming molecules can be used in combination with a donor DNA fragment to facilitate genome modification in vitro and in vivo. In some embodiments, the oligomers have between 1 and 50 inclusive γ-substituted PNA residues. |
| FILED | Monday, June 22, 2020 |
| APPL NO | 17/620368 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1138 (20130101) Original (OR) Class C12N 2310/15 (20130101) C12N 2310/334 (20130101) C12N 2310/3181 (20130101) C12N 2320/53 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220243213 | Bondy-Denomy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California); THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (TORONTO, Canada) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph Bondy-Denomy (Oakland, California); Adair Borges (Oakland, California); Jenny Yujie Zhang (Oakland, California); Beatriz Osuna, SR. (Oakland, California); Sabrina Stanley (Toronto, Ontario, Canada); Alan Davidson (Toronto, Ontario, Canada) |
| ABSTRACT | The present disclosure provides compositions and methods for introducing or enhancing Aca activity in prokaryotic cells. The provided compositions and methods can be used to inhibit Acr activity in prokaryotic cells, thereby enhancing endogenous or exogenous CRISPR-Cas activity. Cells, polynucleotides, plasmids, phage, and other elements for practicing the present methods are also provided. |
| FILED | Friday, May 29, 2020 |
| APPL NO | 17/613894 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 7/00 (20130101) C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/78 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2795/00022 (20130101) C12N 2795/10042 (20130101) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220243224 | MALIK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CHILDREN'S HOSPITAL MEDICAL CENTER (Cincinnati, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Punam MALIK (Cincinnati, Ohio); William SWANEY (Cincinnati, Ohio) |
| ABSTRACT | Methods of producing and manufacturing retroviral particles. Such methods may involve the use of an ion-exchange column with an elution buffer comprising one or more salts, wherein the elution buffer has a low total salt concentration (e.g., 400 mM to 800 mM) relative to conventional practice. In some embodiments, the retroviral particles can be generated by host cells transfected with retroviral vectors using polyethylenimine (PEI). |
| FILED | Wednesday, April 15, 2020 |
| APPL NO | 17/603774 |
| CURRENT CPC | Peptides C07K 14/805 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0087 (20130101) C12N 5/0647 (20130101) C12N 7/00 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 2500/50 (20130101) C12N 2500/90 (20130101) C12N 2740/10043 (20130101) C12N 2740/10052 (20130101) C12N 2830/008 (20130101) C12N 2830/46 (20130101) C12N 2830/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220243244 | ROMESBERG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Scripps Research Institute (La Jola, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Floyd E. ROMESBERG (La Jolla, California); Emil C. FISCHER (La Jolla, California); Koji HASHIMOTO (La Jolla, California); Aaron W. FELDMAN (La Jolla, California); Vivian T. DIEN (La Jolla, California); Yorke ZHANG (La Jolla, California) |
| ABSTRACT | Disclosed herein are compositions, methods, and kits for a cell incorporating unnatural amino acids into an unnatural polypeptide. Also disclosed herein are compositions, methods, and kits for increasing activity and yield of the unnatural polypeptide synthesized by the cell. |
| FILED | Friday, April 08, 2022 |
| APPL NO | 17/716848 |
| CURRENT CPC | Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220243246 | WANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| INVENTOR(S) | Shaopeng WANG (Chandler, Arizona); Fenni ZHANG (Tempe, Arizona) |
| ABSTRACT | Provided herein are methods of assessing the presence of microbes in a liquid sample that include assessing an initial integrated scattering intensity of objects (IC0) in the sample and an integrated scattering intensity of the objects at a time t (ICt) from modified images of the liquid sample, and identifying the sample as comprising microbes for (ICt)/(IC0) above a predefined infection threshold TI. Related systems and other aspects are also provided. |
| FILED | Tuesday, February 01, 2022 |
| APPL NO | 17/590457 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/06 (20130101) Original (OR) Class C12Q 1/18 (20130101) Image Data Processing or Generation, in General G06T 7/0016 (20130101) G06T 7/246 (20170101) G06T 2207/10056 (20130101) G06T 2207/30024 (20130101) G06T 2207/30241 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220243247 | ARODZ et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VIRGINIA COMMONWEALTH UNIVERSITY (Richmond, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tom ARODZ (Richmond, Virginia); Gregory BUCK (Richmond, Virginia); Kimberly K. JEFFERSON (Richmond, Virginia); Jerome STRAUSS (Richmond, Virginia); Jennifer FETTWEIS (Richmond, Virginia); Myrna SERRANO (Richmond, Virginia); Philippe GIRERD (Richmond, Virginia); Paul BROOKS (Richmond, Virginia); David EDWARDS (Richmond, Virginia) |
| ABSTRACT | A method for determining the risk of an adverse pregnancy outcome for a woman is provided comprising the steps of measuring a level of TM7-H1 and optionally one or more of BVAB1, Sneathia amnii, and Prevotella cluster 2 in a vaginal sample obtained from the woman, and identifying the woman as having an increased risk for an adverse pregnancy outcome, or other adverse pregnancy outcomes, if the levels are increased compared to corresponding standard control levels. Methods for the prophylactic treatment of subjects identified as being at increased risk for an adverse pregnancy outcome are also provided. |
| FILED | Friday, May 01, 2020 |
| APPL NO | 17/608242 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/06 (20130101) Original (OR) Class C12Q 1/689 (20130101) C12Q 2600/16 (20130101) C12Q 2600/118 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220243253 | Bhattacharya et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aniket Bhattacharya (Orlando, Florida); Swarnadeep Seth (Orlando, Florida) |
| ABSTRACT | Methods of accurately determining DNA barcodes using a cylindrical nanopore system. The methods include steps of leveraging the average velocity of a double-stranded DNA segment passing through a single cylindrical nanopore that is measured through repeated scanning to accurately determine protein tag locations on the double-stranded DNA segment. As such, the methods provide for the accurate calculation of a barcode for the double-stranded DNA segment based on protein tag locations without underestimation or overestimate issues. The underlying concept and the methods are equally applicable to other multi-nanopore systems which use the dwell time and time of flight velocities to measure the barcodes. |
| FILED | Tuesday, February 01, 2022 |
| APPL NO | 17/649577 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) Original (OR) Class Electric Digital Data Processing G06F 17/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220243254 | Hung et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Combinati Incorporated (Carlsbad, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ju-Sung Hung (Palo Alto, California); Megan Dueck (Brisbane, California); Andrew Zayac (San Leandro, California) |
| ABSTRACT | The present disclose provides methods and systems for amplifying and quantifying nucleic acids and for detecting the presence or absence of a target in a sample. The methods and systems provided herein may utilize a device comprising a plurality of partitions separated from an external environment by a gas-permeable barrier. Certain methods disclosed herein involve subjecting nucleic acid molecules in the plurality of partitions to conditions sufficient to conduct nucleic acid amplification reactions. The nucleic acid molecules may be subjected to controlled heating in the plurality of partitions to generate data indicative of a melting point(s) of the nucleic acid molecules. |
| FILED | Wednesday, January 19, 2022 |
| APPL NO | 17/578942 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 3/502738 (20130101) B01L 7/52 (20130101) B01L 2200/16 (20130101) B01L 2200/0684 (20130101) B01L 2300/0816 (20130101) B01L 2300/0864 (20130101) B01L 2300/0883 (20130101) B01L 2400/049 (20130101) B01L 2400/0487 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220243263 | BARANY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Francis BARANY (New York, New York); Manny D. BACOLOD (New York, New York); Jianmin HUANG (New York, New York); Aashiq H. MIRZA (New York, New York); Philip B. FEINBERG (New York, New York); Sarah F. GIARDINA (New York, New York) |
| ABSTRACT | The present invention relates to methods for identifying and/or quantifying low abundance, nucleotide base mutations, insertions, deletions, translocations, splice variants, miRNA variants, alternative transcripts, alternative start sites, alternative coding sequences, alternative non-coding sequences, alternative splicings, exon insertions, exon deletions, intron insertions, or other rearrangement at the genome level and/or methylated nucleotide bases. |
| FILED | Friday, May 01, 2020 |
| APPL NO | 17/608537 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6858 (20130101) Original (OR) Class C12Q 1/6886 (20130101) C12Q 2600/154 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) C12Q 2600/178 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220243264 | Hung et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts) |
| INVENTOR(S) | Deborah Hung (Boston, Massachusetts); Peijun Ma (Cambridge, Massachusetts) |
| ABSTRACT | Described in certain example embodiments herein are highly sensitive systems and methods of amplifying RNA in a sample. In certain example embodiments, the method includes reverse transcribing one or more strands of template RNA in the sample into a first cDNA strand in the presence of a first primer comprising a unique molecular identifier (UMI), a second primer comprising a T7 promoter sequence, and a reverse transcriptase enzyme; synthesizing a second cDNA strand in the presence of a DNA polymerase to generate double-stranded cDNA; and transcribing the double-stranded cDNA in the presence of a T7 RNA polymerase to generate amplified RNA. The systems and methods described herein allow for amplification from very small amounts of template RNA, in some embodiments, as little as 0.5 picograms. |
| FILED | Tuesday, November 23, 2021 |
| APPL NO | 17/533213 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1096 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6809 (20130101) C12Q 1/6865 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220243271 | Gruen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | Yale University (New Haven, Connecticut) |
| INVENTOR(S) | Jeffrey R. Gruen (Hamden, Connecticut); Natalie Renee Powers (Bar Harbor, Maine) |
| ABSTRACT | Described herein are the association BV677278 (READ1) with reading disability and language impairment, as well as the synergistic interaction of DCDC2 risk haplotypes or alleles with KIAA0319 risk allele. |
| FILED | Wednesday, September 08, 2021 |
| APPL NO | 17/469800 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/16 (20130101) C12Q 2600/118 (20130101) C12Q 2600/156 (20130101) C12Q 2600/172 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 19/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220243281 | Markowitz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sanford D. Markowitz (Pepper Pike, Ohio); Helen Moinova (Beachwood, Ohio); David Wurtman (New York, New York) |
| ABSTRACT | The disclosure provides methods for storage solutions for preserving DNA methylation patterns over a period of time. The disclosure also provides for methods of using methylated DNA stored in such storage solutions. |
| FILED | Thursday, May 28, 2020 |
| APPL NO | 17/613825 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1003 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/154 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220243288 | WILLIAMS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NORTH CAROLINA STATE UNIVERSITY (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gavin John WILLIAMS (Raleigh, North Carolina); Robert Edward KALKREUTER (Palm Beach Gardens, Florida); Alexandra Anderson MALICO (Raleigh, North Carolina); Melissa MITCHLER (Raleigh, North Carolina) |
| ABSTRACT | The present disclosure relates to biosensors and uses thereof for detecting polyketide extender units. Disclosed herein are biosensor systems and methods for detecting polyketide synthase extender units. In some aspects, disclosed herein is a biosensor system comprising: a first nucleic acid comprising a genetically modified fapR gene, wherein the nucleic acid comprises at least one genetic mutation when compared to the wild-type fapR gene, and wherein the first nucleic acid is operably linked to a first promoter; and a second nucleic acid comprising a reporter gene whose transcription is under the control of a second promoter which is regulated by the fapR transcription factor. |
| FILED | Thursday, May 21, 2020 |
| APPL NO | 17/612277 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/65 (20130101) C12N 15/70 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6897 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220243290 | Poon et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Hong Kong (Hong Kong, China PRC) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Leo LM Poon (Hong Kong, China PRC); Malik Peiris (Hong Kong, China PRC); Daniel K.W. Chu (Hong Kong, China PRC) |
| ABSTRACT | Systems for sensitive and accurate detection of sarbecoviruses in samples from human sputum have been established. The systems can rapidly and effectively diagnose patients having suspected coronavirus infections. The systems employ Reverse-Transcription Quantitative Polymerase Chain Reaction (RT-qPCR) to identify and quantify nucleic acids specific to sarbecoviruses within samples from human patients. The systems identify viral RNAs specific for the N and ORF1 genes using a two-step real-time PCR and the SYBR Green detection method. Compositions and methods for reproducibly detecting and quantifying concentrations of sarbecoviruses with a dynamic range of at least seven orders of magnitude (2×10−4-2000 TCID50/reaction) are described. The compositions and methods enable rapid early diagnosis of patients, as well as development of databases of patient viral titres and infectious dosages. |
| FILED | Wednesday, December 08, 2021 |
| APPL NO | 17/545818 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/701 (20130101) Original (OR) Class C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220243291 | SCHAFFER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David V. SCHAFFER (Berkeley, California); Ryan R. KLIMCZAK (San Francisco, California); James T. KOERBER (San Mateo, California); John G. FLANNERY (Berkeley, California); Deniz DALKARA MOUROT (Berkeley, California); Meike Visel (El Cerrito, California); Leah C.T. BYRNE (Berkeley, California) |
| ABSTRACT | The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells, when administered via intravitreal injection, compared to wild-type AAV. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease. |
| FILED | Tuesday, December 14, 2021 |
| APPL NO | 17/551030 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0048 (20130101) A61K 38/1709 (20130101) A61K 48/0008 (20130101) A61K 48/0025 (20130101) A61K 48/0075 (20130101) Peptides C07K 14/005 (20130101) C07K 2319/33 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) C12N 15/113 (20130101) C12N 15/115 (20130101) C12N 2310/14 (20130101) C12N 2310/16 (20130101) C12N 2320/32 (20130101) C12N 2750/14021 (20130101) C12N 2750/14121 (20130101) C12N 2750/14122 (20130101) C12N 2750/14142 (20130101) C12N 2750/14143 (20130101) C12N 2750/14145 (20130101) C12N 2750/14152 (20130101) C12N 2810/40 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/70 (20130101) C12Q 1/701 (20130101) Original (OR) Class C12Q 2600/16 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5008 (20130101) G01N 33/5058 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220244185 | CHENG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Boston University (Boston, Massachusetts) |
| ASSIGNEE(S) | Trustees of Boston University (Boston, Massachusetts) |
| INVENTOR(S) | Ji-Xin CHENG (Newton, Massachusetts); Haonan LIN (Allston, Massachusetts) |
| ABSTRACT | Systems and methods implement of high-speed delay scanning for spectroscopic SRS imaging characterized by scanning a first pulsed beam across a stepwise reflective surface (such as a stepwise mirror or a reflective blazed grating) in a Littrow configuration to generate near continuous temporal delays relative to a second pulsed beam. Systems and methods also implement deep learning techniques for image restoration of spectroscopic SRS images using a trained encoder-decoder convolution neural network (CNN) which in some embodiments may be designed as a spatial-spectral residual net (SS-ResNet) characterized by two parallel filters including a first convolution filter on the spatial domain and a second convolution filter on the spectral domain. |
| FILED | Thursday, January 06, 2022 |
| APPL NO | 17/569966 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0075 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/65 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/08 (20130101) Image Data Processing or Generation, in General G06T 5/001 (20130101) G06T 2207/20081 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220244228 | van DAM et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | R. Michael van DAM (Sherman Oaks, California); Jia Wang (Los Angeles, California); Alejandra Rios (Los Angeles, California) |
| ABSTRACT | A method of performing high-throughput radio thin layer chromatography (radio-TLC) includes spotting a plurality of locations on one or more TLC plates with samples containing a radiochemical or a radiopharmaceutical, each location defining an individual lane on the one or more TLC plates for the respective samples. The one or more TLC plates are developed with a developing solution and dried. The TLC plates are imaged with an imaging device comprising a camera, wherein the image obtained from the camera comprises a field of view that contains regions of interest (ROIs) from the plurality of lanes. The ROIs in the images obtained from the camera may then be analyzed by the user. The ROIs may be used, for example, reaction optimization or for quality control check of the production of radiotracers. |
| FILED | Wednesday, April 15, 2020 |
| APPL NO | 17/605213 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/95 (20130101) Original (OR) Class G01N 35/10 (20130101) Pictorial Communication, e.g Television H04N 5/372 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220244251 | AUCOIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of regents of the Nevada System of Higher Education on Behalf of the University of Nevada Reno (Reno, Nevada) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David AUCOIN (Reno, Nevada); Kathryn J. PFLUGHOEFT (Reno, Nevada) |
| ABSTRACT | Disclosed herein is a method of detecting and identifying antigens that are shed into human bodily fluids during infection. The disclosed method allows circulating antigens associated with a particular infection to be detected within minutes or hours from testing as compared to days required with the current methods. Methods of identifying diagnostic indicators/targets for a given condition or disease are disclosed which include immunizing a veterinary subject with biological fluids obtained from a human infected with particular antigens to identify diagnostic targets for immunoassay. Also disclosed are methods of diagnosing and monitoring a B. burgdorferi-associated condition, such as Lyme disease. Point-of-care immunoassays are also provided that can be used to diagnose or monitor the efficacy of a B. burgdorferi-associated condition treatment. These immunoassays can also be used for rapid diagnosis of infection produced by B. burgdorferi, such as Lyme disease. |
| FILED | Wednesday, May 27, 2020 |
| APPL NO | 17/614168 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/564 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220244263 | GRAEBER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (12th Floor, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Thomas G. GRAEBER (Los Angeles, California); Nikolas G. BALANIS (Los Angeles, California); Katherine M. SHEU (Los Angeles, California); Owen N. WITTE (Los Angeles, California); Favour ESEDEBE (Los Angeles, California); Jung Wook PARK (Los Angeles, California) |
| ABSTRACT | The current disclosure provides for methods of identifying and treating small cell neuroendocrine (SCN) tumors and small-round-blue cell tumor (SRBCT). Aspects of the disclosure relate to a method comprising measuring the level of expression of one or more biomarkers from Tables 1-3 in a biological sample from a cancer patient. Further aspects relate to a method for treating small cell neuroendocrine (SCN) cancer or small-round-blue cell tumor (SRBCT) in a patient comprising administering a cancer treatment to the patient, wherein the cancer treatment is a treatment selected from Table 4A, 4B, or combinations of treatments from Table 4A and/or 4B. |
| FILED | Thursday, May 28, 2020 |
| APPL NO | 17/613881 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57484 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220244265 | Kulkarni et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pushkar Kulkarni (Boston, Massachusetts); Roger W. Giese (Hanover, Massachusetts); Poguang Wang (Westborough, Massachusetts) |
| ABSTRACT | The disclosure relates to a diazirine precursor mass tag compound represented by structural formula (I) Also disclosed is a method for detecting analytes in a sample, comprising derivatizing the analytes with the compound of formula (I), and detecting the resulting derivatized analytes by a mass or ion mobility spectrometry. |
| FILED | Friday, May 22, 2020 |
| APPL NO | 17/612713 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/7233 (20130101) G01N 33/582 (20130101) Original (OR) Class G01N 2458/15 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220244271 | REED et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California) |
| INVENTOR(S) | Elaine F. REED (LOS ANGELES, California); Michelle HICKEY (LOS ANGELES, California); Carrie L. BUTLER (LOS ANGELES, California); David W. GJERTSON (LOS ANGELES, California) |
| ABSTRACT | The present invention generally relates to transplantation rejection. In particular, the present invention provides compositions, kits, assays, and methods of determining if a subject has allograft rejection, or an increased risk of developing rejection after transplantation, and methods of treatment thereof. |
| FILED | Wednesday, May 06, 2020 |
| APPL NO | 17/595015 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) Original (OR) Class G01N 2800/245 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220244333 | Zhao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shen Zhao (Columbus, Ohio); Rizwan Ahmad (Columbus, Ohio); Lee Potter (Riverlea, Ohio) |
| ABSTRACT | The present disclosure is directed to a computational procedure for accelerated, calibrationless magnetic resonance image (CI-MRI) reconstruction that is fast, memory efficient, and scales to high dimensional imaging. The computational procedure, High-dimensional fast ConvolUtional framework (HICU), provides fast, memory-efficient recovery of unsampled k-space points. |
| FILED | Wednesday, November 24, 2021 |
| APPL NO | 17/535250 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/543 (20130101) G01R 33/4818 (20130101) Original (OR) Class G01R 33/5608 (20130101) G01R 33/5611 (20130101) G01R 33/5619 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220244411 | Goldan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amirhossein Goldan (Stony Brook, New York); Andrew Labella (New Rochelle, New York); Wei Zhao (East Setauket, New York) |
| ABSTRACT | Provided is a particle detection device and method of fabrication thereof. The particle detection device includes a scintillator array that includes a plurality of scintillator crystals; a plurality of detectors provided on a bottom end of the scintillator array; and a plurality of prismatoids provided on a top end of the scintillator array. Prismatoids of the plurality of prismatoids are configured to redirect particles between top ends of crystals of the scintillator array. Bottom ends of a first group of crystals of the scintillator array are configured to direct particles to a first detector of the plurality of detectors and bottom ends of a second group of crystals of the scintillator array are configured to direct particles to a second detector substantially adjacent to the first detector. |
| FILED | Monday, April 25, 2022 |
| APPL NO | 17/727995 |
| CURRENT CPC | Measurement of Nuclear or X-radiation G01T 1/29 (20130101) G01T 1/202 (20130101) Original (OR) Class G01T 1/1641 (20130101) G01T 1/2002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220244517 | Dickensheets et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MONTANA STATE UNIVERSITY (BOZEMAN, Montana); MEMORIA SLOAN-KETTERING CANCER CENTER (NEW YORK, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Dickensheets (Bozeman, Montana); Milind Rajadhyaksha (New York, New York) |
| ABSTRACT | A device for viewing a target, the device including a housing, an objective lens positioned within the housing, where the objective lens has a first lens group including at least a first lens and a second lens group including at least a second lens, the first lens positioned closer to the target than the second lens, and a camera positioned within the objective lens between the first lens and the second lens, where the camera is configured to provide images of the target located near a focal point of the objective lens, and wherein the arrangement of the first lens, the second lens, and the camera provides for simultaneous capture of a first image of a surface of the target and a second image of a sub-surface cellular structure of the target. |
| FILED | Monday, April 11, 2022 |
| APPL NO | 17/717774 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0068 (20130101) A61B 5/0075 (20130101) A61B 5/0077 (20130101) A61B 5/444 (20130101) Optical Elements, Systems, or Apparatus G02B 21/02 (20130101) G02B 21/06 (20130101) G02B 21/0008 (20130101) G02B 21/0028 (20130101) G02B 21/0036 (20130101) G02B 21/361 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220247908 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lihong Wang (Arcadia, California); Taewoo Kim (Alhambra, California); Jinyang Liang (Varennes, Canada); Liren Zhu (Sunnyvale, California) |
| ABSTRACT | Among the various aspects of the present disclosure is the provision of systems and methods of phase-sensitive compressed ultrafast photography. |
| FILED | Monday, March 02, 2020 |
| APPL NO | 16/806691 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/4814 (20130101) G01S 7/4865 (20130101) G01S 17/894 (20200101) Optical Elements, Systems, or Apparatus G02B 5/04 (20130101) Pictorial Communication, e.g Television H04N 5/2352 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220248238 | MELODIA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tommaso MELODIA (Newton, Massachusetts); Leonardo BONATI (Boston, Massachusetts); Salvatore D'ORO (Allston, Massachusetts) |
| ABSTRACT | A self-optimizing operating system for next-generation cellular networks is provided. The system provides telecommunications operators with an efficient and flexible network control platform that hides low-level network details through a virtual network abstraction and allows them to define centralized and high-level control objectives with no need for in-depth and detailed knowledge of cross-layer optimization theory or the underlying wireless protocol stack implementation. |
| FILED | Friday, May 01, 2020 |
| APPL NO | 17/605266 |
| CURRENT CPC | Wireless Communication Networks H04W 24/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20220240762 | Rentschler et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a Body Corporate (Denver, Colorado); Aspero Medical, Inc. (Boulder, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark E. Rentschler (Boulder, Colorado); Allison B. Lyle (Boulder, Colorado); Jeffrey P. Castleberry (Longmont, Colorado) |
| ABSTRACT | An overtube assembly for use with an elongate medical includes a flexible tubular body having a proximal end and a distal end, the flexible tubular body including a tube split extending longitudinally from the proximal end to the distal end. The flexible tubular body defines each of a primary lumen extending from the proximal end to the distal end and accessible through the tube split and a secondary lumen separate from the primary lumen. |
| FILED | Thursday, April 14, 2022 |
| APPL NO | 17/721157 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/00082 (20130101) A61B 1/00135 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220240864 | Yin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| INVENTOR(S) | Hongxu Yin (Princeton, New Jersey); Bilal Mukadam (Plano, Texas); Xiaoliang Dai (Princeton, New Jersey); Niraj K. Jha (Princeton, New Jersey) |
| ABSTRACT | According to various embodiments, a machine-learning based system for diabetes analysis is disclosed. The system includes one or more processors configured to interact with a plurality of wearable medical sensors (WMSs). The processors are configured to receive physiological data from the WMSs and demographic data from a user interface. The processors are further configured to train at least one neural network based on a grow-and-prune paradigm to generate at least one diabetes inference model. The neural network grows at least one of connections and neurons based on gradient information and prunes away at least one of connections and neurons based on magnitude information. The processors are also configured to output a diabetes-based decision by inputting the received physiological data and demographic data into the generated diabetes inference model. |
| FILED | Tuesday, June 16, 2020 |
| APPL NO | 17/619449 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/681 (20130101) A61B 5/02055 (20130101) A61B 5/7264 (20130101) Original (OR) Class A61B 5/7271 (20130101) Computer Systems Based on Specific Computational Models G06N 3/082 (20130101) G06N 3/0454 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220241198 | Weitz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David A. Weitz (Cambridge, Massachusetts); Joerg G. Werner (Medford, Massachusetts); Julie V. Brouchon (Cambridge, Massachusetts); John Heyman (Cambridge, Massachusetts); Brendan Deveney (Cambridge, Massachusetts) |
| ABSTRACT | The present invention generally relates to polymers and, in particular, to copolymers for stabilizing, e.g., emulsions or droplets. In certain aspects, the copolymers may comprise a relatively hydrophobic monomer and a relatively hydrophilic monomer polymerized together (e.g., randomly) to form the copolymer. Examples of hydrophobic monomers include methacrylates and vinylphenyls; examples of hydrophilic monomers include boronic acids or acid derivatives. Surprisingly, such random copolymers may act as surfactants, e.g., stabilizing droplets within the emulsion. In addition, in some cases, an interfacial film may be produced by exposing the copolymer to a complexing molecule, such as a polyol, that can complex with the copolymer to form the film. In some cases, the film may at least partially surround a droplet, and in certain embodiments, the film may be sufficiently sturdy such that the droplet can be removed from the emulsion. Other aspects include methods of making or using such copolymers (for example, for containing cells in droplets), kits involving such copolymers, or the like. |
| FILED | Friday, May 22, 2020 |
| APPL NO | 17/613023 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/107 (20130101) Original (OR) Class A61K 9/5026 (20130101) A61K 9/5089 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 220/14 (20130101) C08F 220/24 (20130101) C08F 220/56 (20130101) C08F 220/1802 (20200201) C08F 220/1806 (20200201) C08F 230/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220241317 | Duvall et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Craig L. Duvall (Nashville, Tennessee); Samantha M. Sarett (Nashville, Tennessee); Thomas A. Werfel (Nashville, Tennessee) |
| ABSTRACT | Provided herein are compounds and methods for gene silencing. The compound includes a RNA directly conjugated to an albumin-binding group. The method includes administering a compound comprising a RNA directly conjugated to an albumin-binding group to a subject in need thereof. |
| FILED | Tuesday, September 14, 2021 |
| APPL NO | 17/474765 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/7105 (20130101) Original (OR) Class A61K 47/543 (20170801) Peptides C07K 14/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) C12N 2310/14 (20130101) C12N 2310/141 (20130101) C12N 2310/3515 (20130101) C12N 2320/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220242036 | Batelaan et al. |
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| FUNDED BY |
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| APPLICANT(S) | NUtech Ventures (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Herman Batelaan (Lincoln, Nebraska); Phillip Wiebe (Lincoln, Nebraska) |
| ABSTRACT | A method of forming a monolithic electron optics component includes providing a dual-nozzle printing head having first and second printing nozzles, heating the dual-nozzle printing head to a desired temperature so that both the first nozzle and the second nozzle are heated to substantially the same, desired temperature, extruding a non-conductive filament material through the first nozzle, and withdrawing a conductive filament material through the second nozzle to form a device component. The desired temperature is typically above a melting temperature of the conductive filament material, above the melting temperature of the non-conducting filament material and lower than the temperature at which the printed device component or object sags under its own weight after printing and bleeding of the non-conducting filament material over the conducting filament material occurs. |
| FILED | Wednesday, April 20, 2022 |
| APPL NO | 17/724656 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/118 (20170801) Original (OR) Class Producing Particular Articles From Plastics or From Substances in a Plastic State B29D 11/0074 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2067/046 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220242740 | Hersam et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark C. Hersam (Wilmette, Illinois); Xiaolong Liu (Ithaca, New York) |
| ABSTRACT | The invention relates to two dimensional (2D) heterostructures and methods of fabricating the same. The 2D hetero structures are integration of borophene with graphene and 2D lateral and vertical hetero structures with sharp and rotationally commensurate interfaces. The rich bonding configurations of boron indicate that borophene can be integrated into a diverse range of 2D heterostructures. |
| FILED | Wednesday, June 17, 2020 |
| APPL NO | 17/617367 |
| CURRENT CPC | Processes for Applying Fluent Materials to Surfaces, in General B05D 5/12 (20130101) Non-metallic Elements; Compounds Thereof; C01B 35/04 (20130101) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/20 (20130101) C01P 2002/60 (20130101) C01P 2004/90 (20130101) C01P 2006/40 (20130101) C01P 2006/90 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/04 (20130101) C23C 14/12 (20130101) C23C 14/24 (20130101) C23C 16/04 (20130101) C23C 16/22 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/06 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/008 (20130101) H01L 51/0011 (20130101) H01L 51/0053 (20130101) H01L 51/0096 (20130101) H01L 2251/301 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220242787 | Akono |
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| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ange-Therese Akono (Evanston, Illinois) |
| ABSTRACT | Methods for the dispersion and synthesis of graphene nanoplatelet-cement composites and helical carbon nanotube composites with high concentrations of graphene nanoplatelets or helical carbon nanotubes that do not require chemical dispersion aids or dispersion-enhancing chemical surface functionalization are provided. Also provided are the reinforced cement composites made using the methods. |
| FILED | Monday, January 31, 2022 |
| APPL NO | 17/588586 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 14/026 (20130101) C04B 28/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220242992 | Huang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jen-Yu Huang (Ithaca, New York); Tobias Hanrath (Ithaca, New York); Han-Yuan Liu (Ithaca, New York) |
| ABSTRACT | Compositions including a plurality of reactive components. The reactive components each include an inorganic core with one or more photoresponsive ligand(s) covalently bonded to a surface of the inorganic core. A composition may also include a photoinitiator. Methods of making an article of manufacture includes photochemically reacting at least a portion of one or more layer(s) formed from one or more composition(s). The photochemical reaction may be carried using a laser as a source of electromagnetic radiation. An article of manufacture, which may be a three-dimensional article of manufacture, may be or is a part of a microfluidic device, HPLC column, fluidic channel, point of care device, or diagnostics device. |
| FILED | Wednesday, June 24, 2020 |
| APPL NO | 17/621910 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/165 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/10 (20200101) B33Y 80/00 (20141201) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 292/00 (20130101) Original (OR) Class Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 133/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220243036 | Hersam et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark C. Hersam (Wilmette, Illinois); Ana Carolina Mazarin de Moraes (Chicago, Illinois) |
| ABSTRACT | A composite film usable as a separator of an electrochemical device includes hBN nanosheets and at least one polymer. The hBN nanosheets are uniformly dispersed within a matrix of said least one polymer to achieve a highly porous microstructure. Said at least one polymer comprises one or more electrically insulating and electrochemically inert polymers. |
| FILED | Friday, July 24, 2020 |
| APPL NO | 17/626602 |
| CURRENT CPC | Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/04 (20130101) C08K 3/38 (20130101) C08K 9/02 (20130101) Original (OR) Class C08K 2003/385 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220243155 | RIVET et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York) |
| ASSIGNEE(S) | RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York) |
| INVENTOR(S) | Christopher John RIVET (Troy, New York); Gregory Patrick DESMOND (Marshfield, Massachusetts); Jonathan Michael ZUIDEMA (Grand Haven, Michigan); Ryan James GILBERT (Troy, New York) |
| ABSTRACT | Cell culture devices, and related methods and kits, for modeling isotropic-to-anisotropic cellular transitions are provided. The devices can include a substrate having an isotropic film surface with one or more regions of aligned fibers dispersed thereon. |
| FILED | Tuesday, September 07, 2021 |
| APPL NO | 17/467834 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) Original (OR) Class C12M 23/20 (20130101) C12M 25/14 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0068 (20130101) C12N 5/0622 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220243156 | LARKIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan); STEL TECHNOLOGIES, LLC (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | LISA M. LARKIN (Ann Arbor, Michigan); ELLEN M. ARRUDA (Ann Arbor, Michigan); MICHAEL J. SMIETANA (Memphis, Tennessee); PABLO MONCADO-LARROTIZ (San Francisco, California); HALEY TITINGER (Ann Arbor, Michigan) |
| ABSTRACT | A bioreactor capable of producing complex, three-dimensional tissue constructs has improved media transfer and increased controllability with regard to exposure to the external environment. The bioreactor includes an external surface, a first tissue culture side for culturing a first cell source in a first tissue culture support region, a second tissue culture side for culturing a second cell source in a second tissue culture support region, and a plurality of ports. At least one of the ports of the plurality of ports extend from the first tissue culture support region of the first tissue culture side to the external surface. The plurality of ports can include an external port that is configured to be a liquid inlet when the bioreactor is in a first orientation and a gas outlet when the bioreactor is in a second orientation. |
| FILED | Sunday, May 24, 2020 |
| APPL NO | 17/614257 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) Original (OR) Class C12M 23/02 (20130101) C12M 23/22 (20130101) C12M 25/04 (20130101) C12M 29/10 (20130101) C12M 29/20 (20130101) C12M 35/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220243164 | GARCIA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Kytopen Corporation (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paulo Andres GARCIA (Somerville, Massachusetts); Rameech MCCORMACK (Cambridge, Massachusetts); Jessica SIDO (Alton, Illinois); James HEMPHILL (Medford, Massachusetts); Harrison BRALOWER (Somerville, Massachusetts); Ross BEIGHLEY (Cambridge, Massachusetts); Cullen BUIE (Cambridge, Massachusetts); Bethany GRANT (Scituate, Massachusetts) |
| ABSTRACT | Devices, systems, and kits for cell transfection are provided. A device includes a first electrode, a second electrode, and an electroporation zone therebetween where an electrical potential difference applied to the first and second electrodes generates an electric field in the electroporation zone sufficient to transfect at least a subset of the cells in the flow path. Methods of introducing a composition into at least a portion of a plurality of cells using the devices, systems, and kits of the invention are also provided. |
| FILED | Thursday, July 02, 2020 |
| APPL NO | 17/624535 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 1/42 (20130101) C12M 35/02 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0645 (20130101) C12N 5/0646 (20130101) C12N 13/00 (20130101) C12N 15/87 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220243171 | ANGELINI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas Ettor ANGELINI (Gainesville, Florida); Cameron D MORLEY (Gainesville, Florida); Christopher S. O'BRYAN (Gainesville, Florida); Peter S. MCFETRIDGE (Gainesville, Florida); Malisa SARNTINORANONT (Gainesville, Florida); Tanmay P. LELE (Gainesville, Florida); Naohiro Terada (Nishinomiya, Japan) |
| ABSTRACT | Described herein are systems and methods relating to three-dimensional (3D) cell manufacturing utilizing a 3D growth media. According to aspects of the present disclosure, pluralities of cells and ECM components can be printed into a bioreactor as a sheet. Sheets can be retrieved, digested, split, and re-printed, thereby expanding the number of cells in an efficient manner that conserves space in a tissue culture incubator, conserves bioreactor consumables, and consumes nutrients required for cell maintenance and growth. |
| FILED | Wednesday, July 01, 2020 |
| APPL NO | 17/622102 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 25/14 (20130101) C12M 29/10 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0062 (20130101) Original (OR) Class C12N 2511/00 (20130101) C12N 2513/00 (20130101) C12N 2533/90 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220243351 | Tao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Meng Tao (Fountain Hills, Arizona); Laidong Wang (Cupertino, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Meng Tao (Fountain Hills, Arizona); Laidong Wang (Cupertino, California) |
| ABSTRACT | Methods for light-induced electroplating of aluminum are disclosed herein. Exemplary methods may comprise preparing an ionic liquid comprising aluminum chloride (AlCl3) and an organic halide, placing the silicon substrate into the ionic liquid, illuminating the silicon substrate, the illumination passing through the ionic liquid, and depositing aluminum onto the silicon substrate via a light-induced electroplating process, wherein the light-induced electroplating process utilizes an applied current that does not exceed a photo-generated current generated by the illumination. |
| FILED | Thursday, April 21, 2022 |
| APPL NO | 17/725855 |
| CURRENT CPC | Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 3/54 (20130101) C25D 3/665 (20130101) Original (OR) Class C25D 5/011 (20200801) C25D 7/12 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/028 (20130101) H01L 31/068 (20130101) H01L 31/0682 (20130101) H01L 31/1804 (20130101) H01L 31/022425 (20130101) H01L 31/022458 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220244172 | Gupta et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Nikira Labs Inc. (Mountain View, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Manish Gupta (Mountain View, California); Rupal Gupta (Mountain VIew, California) |
| ABSTRACT | An optical system for performing an absorption measurement of a medium sample includes a laser source configured to output a laser beam having a wavelength corresponding to an absorption region of interest; a ringdown cavity comprising a chamber configured to receive the medium sample, an input mirror at an input end, an output mirror at an output end, and an optical axis that extends through the centers of the input mirror and the output mirror; a coupling device configured to couple the laser beam through the input mirror into the chamber; and a detector optically coupled with the cavity, and configured to detect an intensity of light of the wavelength corresponding to the absorption region of interest that extends through the output mirror, wherein a cavity geometry of the cavity increases the re-entrant condition of the cavity relative to a conventional cavity comprised of two spherical mirrors. |
| FILED | Wednesday, February 03, 2021 |
| APPL NO | 17/166661 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/31 (20130101) Original (OR) Class G01N 2201/0231 (20130101) G01N 2201/0633 (20130101) G01N 2201/0636 (20130101) G01N 2201/06113 (20130101) Optical Elements, Systems, or Apparatus G02B 5/10 (20130101) G02B 27/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220244215 | Huang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yue Huang (East Lansing, Michigan); Stanley Zuo (Danville, Illinois) |
| ASSIGNEE(S) | LabSys LLC (EAST LANSING, Michigan) |
| INVENTOR(S) | Yue Huang (East Lansing, Michigan); Stanley Zuo (Danville, Illinois) |
| ABSTRACT | A microfabricated electrochemical gas sensor is disclosed. The sensor includes electrodes produced from conductor layers, a capping layer, microcavities through the conductor layers and the capping layer, a cavity connecting the microcavities, and an electrolyte filling in the space created by the cavity and the microcavities in the substrate. The microcavities allow gases to pass through but retain the electrolyte through surface tension. |
| FILED | Tuesday, February 02, 2021 |
| APPL NO | 17/165521 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/4141 (20130101) Original (OR) Class G01N 27/4162 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220244442 | RUBIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Noah A. RUBIN (Cambridge, Massachusetts); Federico CAPASSO (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure provides an optical component, which may be a metasurface grating, including (a) a substrate; and (b) an array of subwavelength-spaced phase-shifting elements, which are tessellated on the substrate to produce, when illuminated with a polarized incident light, a diffracted light beam with a distinct polarization state for each of a finite number of diffraction orders, wherein the finite number is 2 or more. |
| FILED | Wednesday, October 13, 2021 |
| APPL NO | 17/500913 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 4/04 (20130101) Optical Elements, Systems, or Apparatus G02B 5/3025 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220244517 | Dickensheets et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MONTANA STATE UNIVERSITY (BOZEMAN, Montana); MEMORIA SLOAN-KETTERING CANCER CENTER (NEW YORK, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Dickensheets (Bozeman, Montana); Milind Rajadhyaksha (New York, New York) |
| ABSTRACT | A device for viewing a target, the device including a housing, an objective lens positioned within the housing, where the objective lens has a first lens group including at least a first lens and a second lens group including at least a second lens, the first lens positioned closer to the target than the second lens, and a camera positioned within the objective lens between the first lens and the second lens, where the camera is configured to provide images of the target located near a focal point of the objective lens, and wherein the arrangement of the first lens, the second lens, and the camera provides for simultaneous capture of a first image of a surface of the target and a second image of a sub-surface cellular structure of the target. |
| FILED | Monday, April 11, 2022 |
| APPL NO | 17/717774 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0068 (20130101) A61B 5/0075 (20130101) A61B 5/0077 (20130101) A61B 5/444 (20130101) Optical Elements, Systems, or Apparatus G02B 21/02 (20130101) G02B 21/06 (20130101) G02B 21/0008 (20130101) G02B 21/0028 (20130101) G02B 21/0036 (20130101) G02B 21/361 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220244560 | Maddox et al. |
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| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina); Mizar Imaging, LLC (Woods Hole, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul Samuel Maddox (Chapel Hill, North Carolina); Tanner Christian Fadero (Chapel Hill, North Carolina); Joel Carter Smith (East Falmouth, Massachusetts) |
| ABSTRACT | Methods for imaging a sample using fluorescence microscopy, systems for imaging a sample using fluorescence microscopy, and illumination systems for fluorescence microscopes. In some examples, a method includes positioning the sample such that a plane of interest of the sample is coplanar with a focal plane of a detection objective of a microscope; positioning a mirror around the sample; directing a beam of annularly collimated excitation light on the mirror to focus a disc of light on the sample; and imaging the sample through the detection objective. |
| FILED | Wednesday, April 20, 2022 |
| APPL NO | 17/725501 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6458 (20130101) G01N 21/6486 (20130101) G01N 2021/6463 (20130101) Optical Elements, Systems, or Apparatus G02B 21/02 (20130101) G02B 21/08 (20130101) G02B 27/58 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220244953 | JI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The George Washington University (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yuede JI (Washington, District of Columbia); Hao Howie Huang (McLean, Virginia) |
| ABSTRACT | A binary code similarity detection system that compares a target binary code to a source code by comparing the target binary code to a comparing binary generated by compiling the source code. Rather than using a comparing binary generated using a random or fixed compiling configuration, the system identifies the compiling configuration of the target binary code and compares the target binary code to a comparing binary generated using the same compiling configuration as the target binary code. The compiling configuration of the target binary code may be identified by a neural network (e.g., a graph attention network trained on attributed function call graphs of binary codes with known compiling configurations). The target binary code and the comparing binary may be compared using a graph neural network (e.g., a graph triplet loss network) that compares attributed control flow graphs of the of the target binary code and the comparing binary. |
| FILED | Friday, May 21, 2021 |
| APPL NO | 17/327351 |
| CURRENT CPC | Electric Digital Data Processing G06F 8/41 (20130101) G06F 8/751 (20130101) Original (OR) Class G06F 16/9024 (20190101) Computer Systems Based on Specific Computational Models G06N 3/084 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220244965 | Lucia et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brandon Lucia (Pittsburgh, Pennsylvania); Nathan Beckmann (Pittsburgh, Pennsylvania); Graham Gobieski (Pittsburgh, Pennsylvania) |
| ABSTRACT | Disclosed herein is a framework to generate ULP, energy-minimal coarse-grain reconfigurable arrays that execute in a spatial vector-dataflow fashion, mapping a dataflow graph spatially across a fabric of processing elements, applying the same DFG to many input data values, and routing intermediate values directly from producers to consumers. The spatial vector-dataflow minimizes instruction and data-movement energy and also eliminates unnecessary a switching activity because operations do not share execution hardware. |
| FILED | Tuesday, January 11, 2022 |
| APPL NO | 17/572925 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/3851 (20130101) G06F 9/3869 (20130101) Original (OR) Class G06F 9/4494 (20180201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220245225 | Hou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Daqing Hou (Potsdam, New York); Stephanie Schuckers (Potsdam, New York); Mahesh Banavar (Potsdam, New York); Blaine Ayotte (Potsdam, New York) |
| ASSIGNEE(S) | Clarkson University (Potsdam, New York) |
| INVENTOR(S) | Daqing Hou (Potsdam, New York); Stephanie Schuckers (Potsdam, New York); Mahesh Banavar (Potsdam, New York); Blaine Ayotte (Potsdam, New York) |
| ABSTRACT | A system and method to authenticate users on a computing system using a free text behavioral biometric method by recording on the computer system a dataset for each user to be authenticated to create a user profile for each user to be authenticated, each data set comprising a plurality of free-text keystrokes entered by a respective user on a computer that is part of the computing system, and storing each user profile in the memory, subsequently collecting the keystrokes of a user to be authenticated as the user enters text on a keyboard connected to the computing system, creating a plurality of graphs based on the collection of keystrokes entered by the user and calculating n instance based tail area density (ITAD) metric, and then combining the ITAD metric for each graph duration into a single similarity score. |
| FILED | Wednesday, February 02, 2022 |
| APPL NO | 17/591385 |
| CURRENT CPC | Electric Digital Data Processing G06F 11/3438 (20130101) G06F 21/32 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220245538 | Davis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Jim Davis (Los Angeles, California); John Dyck (Newbury, Ohio); Haresh Malkani (Pittsburgh, Pennsylvania); Prakashan P. Korambath (Calabasas, California); Jonathan Wise (Chardon, Ohio) |
| ABSTRACT | Data centric smart manufacturing systems are described. In an embodiment, the data centric smart manufacturing system includes several systems providing raw data, several reusable data model profiles that ingest the raw data and contextualize the raw data, where a data model profile defines contextualized data, configurations, and data connectivity protocols for a particular type of system, and several data transformation models integrated with the data model profiles and instantiated with contextualized data to provide higher level operational insights. |
| FILED | Friday, August 21, 2020 |
| APPL NO | 17/753114 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/067 (20130101) Original (OR) Class G06Q 50/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220246430 | Daus et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alwin S. Daus (Mountain View, California); Sam Vaziri (Mountain View, California); Eric Pop (Palo Alto, California) |
| ABSTRACT | In certain examples, methods and semiconductor structures are directed to multilayered structures including TMD (transition metal dichalcogenide material or TMD-like material and a polymer-based layer which is characterized as exhibiting flexibility. A first layer including a TMD-based material (e.g., an atomic-thick layer including TMD) or TMD-like material is provided or grown on a surface which in certain instances may be a rigid platform or substrate. A plurality of electrodes are provided on or as part of the first layer, and another layer or film including polymer is applied to cover the first layer and the electrodes. The other layer is integrated with the TMD material or TMD-like material and the first layer, and the other layer provides a flexible substrate such as when released from the exemplary rigid platform or substrate. |
| FILED | Friday, June 19, 2020 |
| APPL NO | 17/619514 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/02422 (20130101) H01L 21/02568 (20130101) Original (OR) Class H01L 29/401 (20130101) H01L 29/0673 (20130101) H01L 29/41775 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220246714 | SPANIER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Drexel University (Philadelphia, Pennsylvania); THE PENN STATE RESEARCH FOUNDATION (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan E. SPANIER (Bala Cynwyd, Pennsylvania); Aleksandr V. PLOKHIKH (Philadelphia, Pennsylvania); Matthias FALMBIGL (Philadelphia, Pennsylvania); Roman ENGEL-HERBERT (University Park, Pennsylvania); Jason LAPANO (University Park, Pennsylvania); Iryna S. GOLOVINA (Philadelphia, Pennsylvania) |
| ABSTRACT | The present disclosure provides a layering structure that permits integration of epitaxially oriented perovskite oxides, such as bismuth ferrite (BiFeO3), epitaxially oriented barium titanate (BaTiO3), epitaxially oriented (SrTiO3), or their superstructures (BTO/STO) or solid solutions, onto a Si substrate through a perovskite buffer layer. The structure can retain thermal process-sensitive dopant positions and other thermal process window-sensitive features through atomic layer deposition of an oxide perovskite. Also provided are methods of preparing these layered structures. |
| FILED | Wednesday, April 29, 2020 |
| APPL NO | 17/607726 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0228 (20130101) H01L 21/02197 (20130101) H01L 21/02304 (20130101) H01L 21/02356 (20130101) H01L 28/56 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220246948 | DUAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Xiangfeng DUAN (Los Angeles, California); Yu HUANG (Los Angeles, California); Chengzhang WAN (Los Angeles, California); Mufan LI (Los Angeles, California) |
| ABSTRACT | Provided herein are catalyst materials comprising a catalyst support; and PtM′ nanowires affixed to the catalyst support, wherein the PtM′ nanowires include single atomic species of M′ at exterior surfaces of the PtM′ nanowires, and M′ represents at least one metal, e.g., a metal different from Pt. Also disclosed are manufacturing methods comprising: providing initial MM′ nanowires having an initial molar ratio of M:M′, wherein M is a noble metal, and M′ is a metal different from M; subjecting the initial MM′ nanowires to electrochemical dealloying to partially remove M′ and form partially dealloyed MM′ nanowires having a subsequent molar ratio of M:M′, wherein the subsequent molar ratio of M:M′ is greater than the initial molar ratio of M:M′; and affixing the partially dealloyed MM′ nanowires to a catalyst support. |
| FILED | Tuesday, April 21, 2020 |
| APPL NO | 17/605192 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 11/081 (20210101) C25B 11/089 (20210101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/921 (20130101) H01M 4/925 (20130101) Original (OR) Class H01M 12/06 (20130101) H01M 12/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220246998 | Choi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kyoung-Shin Choi (Fitchburg, Wisconsin); Dohwan Nam (Madison, Wisconsin); Margaret Lumley (Madison, Wisconsin) |
| ABSTRACT | Dual-functional energy storage systems that couple ion extraction and recovery with energy storage and release are provided. The dual-functional energy storage systems use ion-extraction and ion-recovery as charging processes. As the energy used for the ion extraction and ion recovery processes is not consumed, but rather stored in the system through the charging process, and the majority of the energy stored during charging can be recovered during discharging, the dual-functional energy storage systems perform useful functions, such as solution desalination or lithium-ion recovery with a minimal energy input, while storing and releasing energy like a conventional energy storage system. |
| FILED | Tuesday, February 02, 2021 |
| APPL NO | 17/165081 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/184 (20130101) H01M 10/36 (20130101) H01M 10/44 (20130101) Original (OR) Class H01M 2300/0002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220247075 | Jalili et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Hossein Jalili (Atlanta, Georgia); Omeed Momeni (Davis, California) |
| ABSTRACT | In one aspect, a system that provides a lens-integrated reconfigurable radiating source capable of two-dimensional continuous beam steering is disclosed. The system can include a silicon (Si) chip that further comprises a two-dimensional (2D) array of pixel sources/unit cells, wherein each unit cell in the 2D array includes an on-chip antenna for radiating power. The system further includes Si lens coupled to the silicon chip for controlling a directivity of a radiation beam generated by the chip. Note that the unit cells in the 2D array of unit cells can be independently activated to generate high-directivity radiation beams in a discrete set of firing angles. Moreover, the 2D array is configured to effectuate injection locking between adjacent unit cells in the 2D array when the adjacent unit cells are turned on simultaneously, wherein the injection locking effectuates a coherent radiation beam that can be continuously steered within a scanning range with fine resolution. |
| FILED | Tuesday, February 01, 2022 |
| APPL NO | 17/590566 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 3/46 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220247437 | Babakhani et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Aydin Babakhani (Los Angeles, California); Seyedmohammadreza Razavian (Los Angeles, California) |
| ABSTRACT | Many embodiments provide a frequency comb receiver that includes a PIN diode, a THz pulse generator block that generates THz tones (LO) for coherent frequency comb detection, an on-chip antenna for broadband detection and a driver stage switched by a series of buffers, where a repetition rate of the LO tones are tunable over a range and determines a spacing between two adjacent tones in the corresponding frequency comb. |
| FILED | Friday, June 26, 2020 |
| APPL NO | 17/596963 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 9/28 (20130101) H01Q 13/10 (20130101) Demodulation or Transference of Modulation From One Carrier to Another H03D 7/12 (20130101) Pulse Technique H03K 3/01 (20130101) Transmission H04B 1/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220248174 | Shoari et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arian Shoari (San Diego, California); Mona Komeijani (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arian Shoari (San Diego, California); Mona Komeijani (San Diego, California) |
| ABSTRACT | This disclosure describes novel schemes and utilities that promote sustainable usage of smartphones. It describes apparatus and methods to prevent phone loss, prevent overheating problems, decrease energy waste of the battery, prevent overcharging, decrease packaging waste, and encourage sustainable behavior among users to increase the life of the electronic product. In addition, this application characterize mechanism for localization of people and objects. The apparatus and methods may be applied to promote sustainable usage of other electronic devices such as tablets, laptops, pocket PCs, personal digital assistants (PDAs), e-readers, wearable devices, and etc. In addition, a framework has been presented which can be applied to promote sustainable behavior for any consumer electronics products including smartphones. In addition, novel localization apparatus and methods is presented in this application that can be applied for general localization/tracking purposes. |
| FILED | Friday, April 15, 2022 |
| APPL NO | 17/721459 |
| CURRENT CPC | Transmission H04B 17/27 (20150115) Wireless Communication Networks H04W 4/023 (20130101) Original (OR) Class H04W 52/0229 (20130101) H04W 68/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220248238 | MELODIA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tommaso MELODIA (Newton, Massachusetts); Leonardo BONATI (Boston, Massachusetts); Salvatore D'ORO (Allston, Massachusetts) |
| ABSTRACT | A self-optimizing operating system for next-generation cellular networks is provided. The system provides telecommunications operators with an efficient and flexible network control platform that hides low-level network details through a virtual network abstraction and allows them to define centralized and high-level control objectives with no need for in-depth and detailed knowledge of cross-layer optimization theory or the underlying wireless protocol stack implementation. |
| FILED | Friday, May 01, 2020 |
| APPL NO | 17/605266 |
| CURRENT CPC | Wireless Communication Networks H04W 24/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20220241730 | BELFORT et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York) |
| ASSIGNEE(S) | RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York) |
| INVENTOR(S) | Georges BELFORT (Albany, New York); Joseph IMBROGNO (Massapequa, New York) |
| ABSTRACT | The present disclosure relates to, inter alia, a modified surface comprising an optically active monomer, a polymeric material having a surface onto which the optically active monomer is covalently bound. In one aspect, a membrane comprising an optically active monomer, a poly(aryl sulfone) membrane having a surface onto which the optically active monomer is covalently bound. The present disclosure also relates to a method of modifying a surface, the method comprising applying sufficient energy to a surface to induce covalent bonding with an optically active monomer, and contacting the optically active monomer with the surface. In one aspect, a method of modifying a surface of a poly(aryl sulfone) membrane is disclosed. In another aspect, a method of synthesizing an optically active monomer is disclosed. In one aspect, a method of filtration of chiral compounds is disclosed. |
| FILED | Thursday, October 07, 2021 |
| APPL NO | 17/496151 |
| CURRENT CPC | Separation B01D 61/007 (20130101) B01D 65/08 (20130101) Original (OR) Class B01D 67/0093 (20130101) B01D 69/02 (20130101) B01D 71/68 (20130101) B01D 71/82 (20130101) Heterocyclic Compounds C07D 207/416 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220241851 | Petrus et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GM Global Technology Operations LLC (Detroit, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ronald J. Petrus (Lake Orion, Michigan); Qigui Wang (Rochester Hills, Michigan); Richard M. Nichols, III (Macomb, Michigan); Brian C. Leuenhagen (Clarkston, Michigan) |
| ABSTRACT | A system for making a hybrid cam bore sand core with metal chills for an engine block includes an engine block cast of an aluminum material. A camshaft bore extends through the engine block. A cam bore sand core with at least one metal chill is positioned within the camshaft bore. A body portion of the at least one metal chill is positioned in direct contact with a cam bearing surface of at least one cam bearing member during casting of the engine block to increase a cooling rate of the at least one cam bearing member and create a crystalline material depth of the cam bearing member having enhanced mechanical properties. |
| FILED | Monday, February 01, 2021 |
| APPL NO | 17/163926 |
| CURRENT CPC | Foundry Moulding B22C 9/10 (20130101) Casting of Metals; Casting of Other Substances by the Same Processes or Devices B22D 15/04 (20130101) Original (OR) Class Cylinders, Pistons or Casings, for Combustion Engines; Arrangements of Sealings in Combustion Engines F02F 1/00 (20130101) F02F 2200/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220242258 | Mohammad et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mostak Mohammad (Oak Ridge, Tennessee); Jason L. Pries (Oak Ridge, Tennessee); Omer C. Onar (Oak Ridge, Tennessee); Veda Prakash Galigekere (Oak Ridge, Tennessee); Gui-Jia Su (Oak Ridge, Tennessee) |
| ABSTRACT | A shield construction for transfer of wireless power is provided. The shield construction be a magnetic shield in the form of a border or frame with respect to aspects of a wireless transmitter or a wireless receiver. The wireless transmitter or the wireless receiver, or both, may be double-D coil based configurations. |
| FILED | Friday, January 28, 2022 |
| APPL NO | 17/587261 |
| CURRENT CPC | Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 53/36 (20190201) B60L 53/126 (20190201) Original (OR) Class Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 27/36 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 50/12 (20160201) H02J 50/90 (20160201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220242394 | Koti et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cummins Inc. (Columbus, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Archit N. Koti (Columbus, Indiana); Rohinish Gupta (Columbus, Indiana); Xing Jin (Columbus, Indiana); Kenneth M. Follen (Greenwood, Indiana); Arun Prakash Thunga Gopal (Columbus, Indiana); Manik Narula (Columbus, Indiana) |
| ABSTRACT | Methods and systems for improving fuel economy and reducing emissions of a vehicle with an electric motor, an engine and an energy storage device are disclosed. The methods and systems involve obtaining lookahead information and current state information, wherein the lookahead information includes a predicted vehicle speed, and the current state information includes a current state of charge (SOC) for the energy storage device coupled to the electric motor; and determining, based on the lookahead information and the current state information, a target power split between the energy storage device and the engine. |
| FILED | Wednesday, May 13, 2020 |
| APPL NO | 17/611082 |
| CURRENT CPC | Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 58/13 (20190201) B60L 2240/12 (20130101) B60L 2240/525 (20130101) B60L 2260/54 (20130101) B60L 2270/12 (20130101) Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 20/16 (20160101) Original (OR) Class B60W 30/1882 (20130101) B60W 40/105 (20130101) B60W 50/0097 (20130101) B60W 2510/244 (20130101) B60W 2520/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220242744 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Jie Li (Darien, Illinois); Mai Kim Tran (Orlando, Florida); Ralph T. Muehleisen (Oak Park, Illinois) |
| ABSTRACT | The invention provides a method for continuously producing composite nanoparticles, the method comprising heating a precursor mixture with supercritical water, wherein the mixture contains a first compound capable of transitioning from a monoclinic to a tetragonal rutile crystal state; cooling the heated mixture to obtain core particles of a predetermined shape and size; encapsulating the core particle with a second precursor to create a core-shell construct; and encapsulating the construct with an organic material. Also provided is a device for continuously synthesizing composite nanoparticles, the device comprising a water supply and a precursor supply; a means for heating the water, a continuous flow hydrothermal reaction chamber adapted to receive the heated water and precursor, a means for chilling the heated water and precursor, and a capping agent supply positioned downstream of the reaction chamber. The invention also provides a nanocomposite particle comprising a core region, and a conformal organic overcoat. |
| FILED | Tuesday, February 02, 2021 |
| APPL NO | 17/165587 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/0013 (20130101) B01J 19/0093 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 31/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220243036 | Hersam et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark C. Hersam (Wilmette, Illinois); Ana Carolina Mazarin de Moraes (Chicago, Illinois) |
| ABSTRACT | A composite film usable as a separator of an electrochemical device includes hBN nanosheets and at least one polymer. The hBN nanosheets are uniformly dispersed within a matrix of said least one polymer to achieve a highly porous microstructure. Said at least one polymer comprises one or more electrically insulating and electrochemically inert polymers. |
| FILED | Friday, July 24, 2020 |
| APPL NO | 17/626602 |
| CURRENT CPC | Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/04 (20130101) C08K 3/38 (20130101) C08K 9/02 (20130101) Original (OR) Class C08K 2003/385 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220243103 | HUN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Diana HUN (Oak Ridge, Tennessee); Pengfei CAO (Oak Ridge, Tennessee); Xiao ZHAO (Oak Ridge, Tennessee); Zoriana DEMCHUK (Oak Ridge, Tennessee); Jiancheng LUO (Oak Ridge, Tennessee); Tomonori SAITO (Oak Ridge, Tennessee) |
| ABSTRACT | A joint sealing system for prefabricated building components is provided. The joint sealing system includes a first component including a first surface, and a second component including a second surface that is mateable with the first surface. The first and second surfaces define a joint. A sealant composition is disposed on one of the first surface or the second surface. Pressure exerted when the second surface is mated with the first surface triggers curing of the sealant composition to join the first and second components and to seal the joint between the first and second components. A method of joining and sealing two prefabricated building components is also provided. |
| FILED | Thursday, February 03, 2022 |
| APPL NO | 17/591886 |
| CURRENT CPC | Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 5/00 (20130101) C09J 11/08 (20130101) C09J 133/08 (20130101) C09J 133/12 (20130101) Original (OR) Class C09J 2433/00 (20130101) C09J 2463/00 (20130101) C09J 2475/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220243234 | Davis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan Wesley Davis (San Jose, California); Fang Liu (Pleasanton, California) |
| ABSTRACT | The present invention relates to methods of providing a biomass residuum and compositions thereof. In particular examples, the biomass residuum includes one or more high value amino acids, even after removal of mixed alcohol components. In particular, the methods include implementing pre-treatment conditions and employing fermentation conditions including modified organisms. |
| FILED | Thursday, April 07, 2022 |
| APPL NO | 17/715602 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/81 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 13/06 (20130101) C12P 13/08 (20130101) Original (OR) Class C12P 13/20 (20130101) C12P 13/24 (20130101) C12P 13/225 (20130101) Enzymes C12Y 101/01001 (20130101) C12Y 101/01086 (20130101) C12Y 202/01006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220243304 | Muralidharan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-BATTELLE, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Govindarajan Muralidharan (Knoxville, Tennessee); Michael P. Brady (Oak Ridge, Tennessee); Yukinori Yamamoto (Knoxville, Tennessee) |
| ABSTRACT | An austenitic Ni-base alloy includes, in weight percent: 2.5 to 4.75 Al; 13 to 21 Cr; 20 to 40 Fe; 2 to 5 total of at least one element selected from the group consisting of Nb and Ta; 0.25 to 4.5 Ti; 0.09 to 1.5 Si; 0 to 0.5 V; 0 to 2 Mn; 0 to 3 Cu; 0 to 2 of Mo and W; 0 to 1 of Zr and Hf; 0 to 0.15 Y; 0.01 to 0.45 C; 0.005 to 0.1 B; 0 to 0.05 P; less than 0.06 N; and balance Ni (38 to 46 Ni). The weight percent Ni is greater than the weight percent Fe. An external continuous scale comprises alumina. A stable phase FCC austenitic matrix microstructure is essentially delta-ferrite-free, and contains one or more carbides and coherent precipitates of γ′ and exhibits creep rupture life of at least 100 h at 900° C. and 50 MPa. |
| FILED | Friday, January 29, 2021 |
| APPL NO | 17/162890 |
| CURRENT CPC | Alloys C22C 19/056 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220243348 | Bekkedahl et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Opus 12 Incorporated (, None) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Timothy A. Bekkedahl (Sunnyvale, California); Kathryn L. Corp (Berkeley, California); Sichao Ma (Dublin, California); Kendra P. Kuhl (Oakland, California); Simon Gregory Stone (Arlington, Massachusetts); Steven George Goebel (Victor, New York) |
| ABSTRACT | Various COx electrolyzer cell architectures are provided, including various flow field designs and gas diffusion layer designs that may be particularly useful in the context of COx electrolyzer cells. |
| FILED | Tuesday, February 01, 2022 |
| APPL NO | 17/649662 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 3/25 (20210101) C25B 3/26 (20210101) C25B 9/07 (20210101) C25B 9/19 (20210101) C25B 9/60 (20210101) C25B 9/70 (20210101) C25B 11/032 (20210101) C25B 15/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220243352 | Xu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaojie Xu (Union City, California); Kyoung Eun Kweon (Pleasonton, California); Christine A. Orme (Oakland, California); Babak Sadigh (Union City, California); April Sawvel (Union City, California) |
| ABSTRACT | A method includes at least partially submerging a substrate in a colloidal mixture of nanocrystals and a first solvent. The nanocrystals have first ligands coupled thereto. The method also includes applying an electric field to the colloidal mixture to form a solvated nanocrystal film and removing the solvated nanocrystal film from the first solvent. The method further includes applying a second solvent to the solvated nanocrystal film for ligand exchange. The second solvent comprises second ligands. A nanocrystal film product formed by one-step ligand exchange includes at least one dimension greater than 100 nm and ordered nanocrystals characterized as having a domain size of greater than 100 nm. |
| FILED | Friday, January 28, 2022 |
| APPL NO | 17/587885 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 20/00 (20130101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 21/00 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/661 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 2/04 (20130101) Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 13/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220243739 | Sarimurat et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mehmet Nasir Sarimurat (Fayetteville, New York); Thong Quoc Dang (East Syracuse, New York) |
| ASSIGNEE(S) | SYRACUSE UNIVERSITY (SYRACUSE, New York) |
| INVENTOR(S) | Mehmet Nasir Sarimurat (Fayetteville, New York); Thong Quoc Dang (East Syracuse, New York) |
| ABSTRACT | An air handler unit for use with residential heating, ventilation, and air conditioning (HVAC) systems. The air handler unit has high resistance mediums (HRMs) coupled closely to a wide-angle vane-diffuser mixed-flow fan system. The HRMs are placed immediately upstream and downstream of the wide-angle vane-diffuser mixed-flow fan to form a closely coupled, compact air handler that provides significant efficiency and noise benefits. |
| FILED | Wednesday, July 01, 2020 |
| APPL NO | 17/621725 |
| CURRENT CPC | Non-positive-displacement Pumps F04D 17/06 (20130101) F04D 29/462 (20130101) F04D 29/542 (20130101) Original (OR) Class F04D 29/584 (20130101) F04D 29/703 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220243749 | Lim et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yong Chae Lim (Oak Ridge, Tennessee); Ji Heon Jun (Oak Ridge, Tennessee); Michael P. Brady (Oak Ridge, Tennessee); Zhili Feng (Oak Ridge, Tennessee) |
| ABSTRACT | A fastener for use in joining dissimilar materials manufactured by the process of producing the fastener with an external surface that forms an electrically insulating oxide layer when subjected to oxidation and, after manufacture and prior to use, subjecting the fastener to a pre-oxidation process to grow the desired oxide layer in situ on the external surface of the fastener. The present invention also provides a dissimilar material joint in which the pre-oxidized fastener is used to mechanically join dissimilar materials with the oxide layer electrically insulating the fastener from at least one of the dissimilar materials. The fastener may be a rivet used in friction self-piercing riveting (F-SPR). The fastener may be fabricated from an alloy capable of forming Al2O3 or Cr2O3 by thermal oxidation. The fastener may be pre-coated with Al or Cr that functions as a seed layer to form Al2O3 or Cr2O3. |
| FILED | Friday, January 29, 2021 |
| APPL NO | 17/162147 |
| CURRENT CPC | Alloys C22C 38/002 (20130101) C22C 38/02 (20130101) C22C 38/005 (20130101) C22C 38/06 (20130101) C22C 38/42 (20130101) C22C 38/44 (20130101) C22C 38/46 (20130101) C22C 38/50 (20130101) C22C 38/54 (20130101) C22C 38/58 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 8/14 (20130101) Devices for Fastening or Securing Constructional Elements or Machine Parts Together, e.g Nails, Bolts, Circlips, Clamps, Clips, Wedges, Joints or Jointing F16B 5/04 (20130101) Original (OR) Class Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors H01R 4/06 (20130101) H01R 4/62 (20130101) H01R 4/70 (20130101) H01R 43/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220243998 | ODUKOMAIYA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado); TCPoly, Inc. (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adewale ODUKOMAIYA (Denver, Colorado); Paramjot SINGH (Lakewood, Colorado); Allison Jasmine MAHVI (Lakewood, Colorado); Matthew Kirby SMITH (Atlanta, Georgia); Kaif DOSANI (Lawrenceville, Georgia) |
| ABSTRACT | The present disclosure relates to encapsulation of a phase change material (PCM) enabled by extrusion of a thermoplastic polymer shell and a PCM core, which can be additively manufactured to form a variety of designs for use in a variety of settings, including for use as thermal energy storage devices in building heating ventilation and air conditioning (HVAC) systems. The thermoplastic polymer shell surrounding a PCM core may be used as a filament in three-dimensional (3D) printing or may be extruded during the additive manufacturing process. |
| FILED | Friday, January 28, 2022 |
| APPL NO | 17/586941 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/165 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 20/023 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220244755 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhaowen Wang (New York, New York); Yudong Zhang (La Jolla, California); Peter Kinget (Summit, New Jersey) |
| ABSTRACT | Circuits and methods for multi-phase clock generators and phase interpolators are provided. The multi-phase clock generators include a delay line and multi-phase injection locked oscillator. At each stage of the multi-phase injection locked oscillator, injection currents are provided from a corresponding stage of the delay line. Outputs of the multi-phase injection locked oscillator and provided to mixers which produce inputs to an operational transconductance amplifier which provides feedback to the delay line and the multi-phase injection locked oscillator. The phase interpolator uses a technique of flipping certain input clock signals to reduce the number of components required while still being able to interpolate phase over 360 degrees and to reduce noise. |
| FILED | Friday, February 04, 2022 |
| APPL NO | 17/665401 |
| CURRENT CPC | Electric Digital Data Processing G06F 1/06 (20130101) Original (OR) Class Generation of Oscillations, Directly or by Frequency-changing, by Circuits Employing Active Elements Which Operate in a Non-switching Manner; Generation of Noise by Such Circuits H03B 27/00 (20130101) H03B 2200/0074 (20130101) Pulse Technique H03K 3/0315 (20130101) H03K 5/133 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220245501 | LI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yufan LI (Baltimore, Maryland); Xiaoying XU (Baltimore, Maryland); Chia-Ling CHIEN (Baltimore, Maryland) |
| ABSTRACT | A qubit device may include a closed loop comprising one or more polycrystalline spin-triplet superconductors. The closed loop may maintain a half-quantum magnetic flux in a ground state. A qubit device may include a closed loop comprising one or more single crystalline spin-triplet superconductors connected by one or more s-wave superconductors. The closed loop may maintain a half-quantum magnetic flux in a ground state. |
| FILED | Wednesday, May 13, 2020 |
| APPL NO | 17/610395 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/0354 (20130101) Computer Systems Based on Specific Computational Models G06N 10/40 (20220101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 39/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220245538 | Davis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Jim Davis (Los Angeles, California); John Dyck (Newbury, Ohio); Haresh Malkani (Pittsburgh, Pennsylvania); Prakashan P. Korambath (Calabasas, California); Jonathan Wise (Chardon, Ohio) |
| ABSTRACT | Data centric smart manufacturing systems are described. In an embodiment, the data centric smart manufacturing system includes several systems providing raw data, several reusable data model profiles that ingest the raw data and contextualize the raw data, where a data model profile defines contextualized data, configurations, and data connectivity protocols for a particular type of system, and several data transformation models integrated with the data model profiles and instantiated with contextualized data to provide higher level operational insights. |
| FILED | Friday, August 21, 2020 |
| APPL NO | 17/753114 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/067 (20130101) Original (OR) Class G06Q 50/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220246240 | Kuznetsov et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gleb Kuznetsov (Cambridge, Massachusetts); Marc J. Lajoie (Cambridge, Massachusetts); Matthieu M. Landon (Boston, Massachusetts); Michael G. Napolitano (Brookline, Massachusetts); Daniel Bryan Goodman (Cambridge, Massachusetts); Christopher J. Gregg (Melrose, Massachusetts); George M. Church (Brookline, Massachusetts); Nili Ostrov (Brookline, Massachusetts) |
| ABSTRACT | Methods and systems for designing, testing, and validating genome designs based on rules or constraints or conditions or parameters or features and scoring are described herein. A computer-implemented method includes receiving data for a known genome and a list of alleles, identifying and removing occurrences of each allele in the known genome, determining a plurality of allele choices with which to replace occurrences in the known genome, generating a plurality of alternative gene sequences for a genome design based on the known genome, wherein each alternative gene sequence comprises a different allele choice, applying a plurality of rules or constraints or conditions or parameters or features to each alternative gene sequence by assigning a score for each rule or constraint or condition or parameter or feature in each alternative gene sequence, resulting in scores for the applied plurality of rules or constraints or conditions or parameters or features, scoring each alternative gene sequence based on a weighted combination of the scores for the plurality of rules or constraints or conditions or parameters or features, and selecting at least one alternative gene sequence as the genome design based on the scoring. |
| FILED | Wednesday, April 13, 2022 |
| APPL NO | 17/719431 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/245 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1089 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/00 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/50 (20190201) G16B 35/10 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220246315 | Lian |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Jie Lian (Niskayuna, New York) |
| ASSIGNEE(S) | RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York) |
| INVENTOR(S) | Jie Lian (Niskayuna, New York) |
| ABSTRACT | One embodiment provides a method of making an oxidation and corrosion resistant nuclear fuel. The method includes refining, by high energy ball milling (HEBM), a nuclear fuel powder comprising at least one nuclear fuel component and sintering the refined powder to form a nuclear fuel pellet. The method may further include adding a powdered dopant to the nuclear fuel powder. The refined powder includes the nuclear fuel powder and the powdered dopant. |
| FILED | Friday, July 24, 2020 |
| APPL NO | 17/629516 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 9/04 (20130101) B22F 2009/043 (20130101) Nuclear Reactors G21C 3/64 (20130101) Original (OR) Class G21C 21/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220246317 | Callaway et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NuScale Power, LLC (Corvallis, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Allyson Callaway (Corvallis, Oregon); Ben Bristol (Philomath, Oregon); Kenneth Rooks (Corvallis, Oregon); Larry Linik (Portland, Oregon) |
| ABSTRACT | A nuclear power system includes a reactor vessel that includes a reactor core that includes nuclear fuel assemblies configured to generate a nuclear fission reaction; a riser positioned above the reactor core; a primary coolant flow path that extends from a bottom portion of the volume through the reactor core and through an annulus between the riser and the reactor vessel; a primary coolant that circulates through the primary coolant flow path to receive heat from the nuclear fission reaction and release the heat to generate electric power in a power generation system; and a control rod assembly system positioned in the reactor vessel and configured to position control rods in only two discrete positions. |
| FILED | Monday, March 14, 2022 |
| APPL NO | 17/693685 |
| CURRENT CPC | Methods of Steam Generation; Steam Boilers F22B 35/004 (20130101) Nuclear Reactors G21C 7/12 (20130101) G21C 7/22 (20130101) Original (OR) Class G21C 9/033 (20130101) Nuclear Power Plant G21D 3/14 (20130101) G21D 3/16 (20130101) G21D 3/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220246319 | Welter |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NuScale Power, LLC (Portland, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kent Welter (Corvallis, Oregon) |
| ABSTRACT | Supports with integrated sensors for nuclear reactor steam generators, and associated systems and methods, are disclosed. A representative method for forming a nuclear-powered steam generator includes forming an instrumented support, the instrumented support including a carrier portion and a retainer portion, with at least one of the carrier portion or the retainer portion being integrally formed with a sensor via an additive manufacturing process. The method can further include coupling the sensor to a communication link, supporting a helical steam conduit on the instrumented support, and installing the helical steam conduit and the instrumented support in a nuclear reactor. The helical steam conduit is positioned along a primary flow path, which is in turn positioned to circulate a heated primary flow in thermal communication with the helical steam conduit. |
| FILED | Thursday, February 04, 2021 |
| APPL NO | 17/168118 |
| CURRENT CPC | Nuclear Reactors G21C 15/182 (20130101) G21C 17/102 (20130101) G21C 17/112 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220246364 | Brambilla |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | FASTCAP SYSTEMS CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicolo Brambilla (Boston, Massachusetts) |
| ABSTRACT | An electric double layer capacitor (EDLC) is disclosed including: a first electrode including a first current collector and first plurality of carbon nanotubes (CNTs) disposed substantially directly upon the first current collector; a second electrode comprising a second current collector and second plurality of CNTs disposed substantially directly upon the second current collector; and an electrolyte disposed between and in contact with (e.g., wetting) the first and second electrodes. In some embodiments, the EDLC is configured to have a capacitive frequency window comprising about 1 Hz to about 50 Hz. |
| FILED | Monday, March 07, 2022 |
| APPL NO | 17/688211 |
| CURRENT CPC | Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/28 (20130101) H01G 11/36 (20130101) H01G 11/52 (20130101) H01G 11/68 (20130101) Original (OR) Class H01G 11/70 (20130101) H01G 11/86 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220246778 | FISHER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Kathryn FISHER (Scottsdale, Arizona); Zachary HOLMAN (Phoenix, Arizona); Charles GAY (Westlake Village, California); David LEVY (Rochester, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kathryn FISHER (Scottsdale, Arizona); Zachary HOLMAN (Phoenix, Arizona); Charles GAY (Westlake Village, California); David LEVY (Rochester, New York) |
| ABSTRACT | A photovoltaic module includes a metal foil defining a multiplicity of electrical contacts, each electrical contact electrically isolated from the other electrical contacts, and a plurality of back-contact photovoltaic cells superimposed over the metal foil and electrically connected via the multiplicity of electrical contacts. Each photovoltaic cell includes a first side configured to absorb light and a second side including a first electrically conductive protrusion and a second electrically conductive protrusion. The first electrically conductive protrusion of a first one of the photovoltaic cells is in direct electrical communication with a first one of the multiplicity of electrical contacts, and the second electrically conductive protrusion of the first one of the photovoltaic cells is in direct electrical communication with a second one of the electrical contacts. |
| FILED | Friday, June 12, 2020 |
| APPL NO | 17/619210 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/18 (20130101) H01L 31/048 (20130101) H01L 31/0516 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220246902 | Deng et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Zenlabs Energy, Inc. (Fremont, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Haixia Deng (Fremont, California); Yongbong Han (San Francisco, California); Charan Masarapu (Fremont, California); Yogesh Kumar Anguchamy (Newark, California); Herman A. Lopez (Sunnyvale, California); Sujeet Kumar (Newark, California) |
| ABSTRACT | Silicon oxide based materials, including composites with various electrical conductive compositions, are formulated into desirable anodes. The anodes can be effectively combined into lithium ion batteries with high capacity cathode materials. In some formulations, supplemental lithium can be used to stabilize cycling as well as to reduce effects of first cycle irreversible capacity loss. Batteries are described with surprisingly good cycling properties with good specific capacities with respect to both cathode active weights and anode active weights. |
| FILED | Wednesday, April 13, 2022 |
| APPL NO | 17/720047 |
| CURRENT CPC | Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/122 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/131 (20130101) Original (OR) Class H01M 4/134 (20130101) H01M 4/136 (20130101) H01M 4/386 (20130101) H01M 4/483 (20130101) H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 4/583 (20130101) H01M 4/624 (20130101) H01M 10/052 (20130101) H01M 10/0525 (20130101) H01M 10/0569 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220246947 | Bhattacharya et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UES, INC. (Dayton, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rabi S. Bhattacharya (Dayton, Ohio); Oleg N. Senkov (Fairborn, Ohio); Prabhakar Singh (Storrs, Connecticut) |
| ABSTRACT | A High Entropy Alloy (HEA) anode for a Solid Oxide Fuel Cell (SOFC), in which the HEA anode comprises: approximately ten (˜10) atomic percent (%) to ˜35% Copper (Cu) (preferably ˜23% to ˜27% Cu, and more preferably ˜24% to ˜26% Cu); ˜10% to ˜35% Iron (Fe) (preferably ˜23% to ˜27% Fe, and more preferably ˜24% to ˜26% Fe); ˜10% to ˜35% Cobalt (Co) (preferably ˜23% to ˜27% Co, and more preferably ˜24% to ˜26% Co); ˜5% to ˜25% Nickel (Ni) (preferably ˜13% to ˜17% Ni, and more preferably ˜14% to ˜16% Ni); ˜5% to ˜20% Manganese (Mn) (preferably ˜8% to 13% Mn, and more preferably ˜9% to 11% Mn); and less than a total of ˜2% other elements as impurities (preferably less than ˜1% total of other elements or impurities, and more preferably less than ˜0.5% total of other elements or impurities), with the sum of all of the alloying elements (Cu, Fe, Co, Ni, Mn, and impurities or other elements) totaling 100%. |
| FILED | Monday, January 31, 2022 |
| APPL NO | 17/589189 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/9066 (20130101) Original (OR) Class H01M 8/12 (20130101) H01M 2008/1293 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220246961 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania); UNITED STATES DEPATMENT OF ENERGY (WASHINGTON, District of Columbia) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania); UNITED STATES DEPATMENT OF ENERGY (WASHINGTON, District of Columbia) |
| INVENTOR(S) | Peng K. Chen (Pittsburgh, Pennsylvania); Jacob Lorenzi Poole (Pittsburgh, Pennsylvania); Paul R. Ohodnicki (Allison Park, Pennsylvania); Thomas D. Brown (Finleyville, Pennsylvania); Kirk R. Gerdes (Morgantown, West Virginia); Michael P. Buric (Pittsburgh, Pennsylvania) |
| ABSTRACT | A method of monitoring operation of a reactor system includes causing a chemical reaction to occur within an assembly of the reactor system, and measuring a chemical composition of one or more reactants of the chemical reaction with spatial resolution at a plurality of points along a path within the assembly using a sensor system structured to implement distributed sensing. The sensor system includes an optical fiber sensing member provided at least partially within the assembly, wherein the optical fiber sensing member comprises a functionalized optical fiber based sensor device structured to exhibit a change in one or more optical properties in response to changes in the chemical composition of the one or more reactants. |
| FILED | Tuesday, April 19, 2022 |
| APPL NO | 17/659672 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/02 (20130101) H01M 8/12 (20130101) H01M 8/2425 (20130101) H01M 8/04328 (20130101) H01M 8/04335 (20130101) H01M 8/04447 (20130101) Original (OR) Class H01M 8/04455 (20130101) H01M 2008/1293 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220247233 | Mohammad et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mostak Mohammad (Oak Ridge, Tennessee); Omer C. Oner (Oak Ridge, Tennessee); Jason L. Pries (Oak Ridge, Tennessee) |
| ABSTRACT | A shield construction for transfer of wireless power is provided. The shield construction may be a magnetic shield having a plurality of layers and provided for a wireless transmitter or a wireless receiver, or both. The magnetic shield may include a first layer and a second layer, where the first layer may be nearer to a core than the second layer, and where the second layer may include a second layer area that is larger than a first layer area of the first layer. The wireless transmitter and the wireless receiver may be configured to multi-phase wireless power transfer. |
| FILED | Friday, January 28, 2022 |
| APPL NO | 17/587265 |
| CURRENT CPC | Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 53/126 (20190201) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 27/36 (20130101) H01F 38/14 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 50/005 (20200101) H02J 50/10 (20160201) H02J 50/70 (20160201) Original (OR) Class H02J 50/402 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220247326 | LAI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Virginia Tech Intellectual Properties, Inc. (Blacksburg, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jih-Sheng LAI (Blacksburg, Virginia); Moonhyun LEE (Torrance, California) |
| ABSTRACT | This disclosure provides systems, methods, and apparatus for multi-level inverters. A hybrid binary cascaded multilevel inverter (BCMLI) is discussed that includes a plurality of H-bridge cells connected in a cascaded formation. DC input voltages of some of the H-bridge cells are provided by DC voltage sources. But inputs of other H-bridge cells coupled with capacitors instead. The H-bridge cells are operated to provide an AC output voltage at the output terminals of the inverter. One or more floating capacitor voltage controllers are used to vary one or more switching instances of the H-bridge cells such that a desirable level or charge is maintained across the one or more capacitors coupled with the input terminals of the H-bridge cells. |
| FILED | Friday, January 28, 2022 |
| APPL NO | 17/587405 |
| CURRENT CPC | Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/0095 (20210501) H02M 3/33573 (20210501) H02M 7/4835 (20210501) Original (OR) Class H02M 7/53871 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20220240787 | Cole et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Aaron Boyd Cole (Bloomington, Indiana); Marcin Stanislaw Malec (Bloomington, Indiana) |
| ABSTRACT | Temperature detection systems and methods for detecting temperature of an object are provided. The system utilizes either a predetermined temperature reference by using a well-behaved and calibrated thermal camera with reliable internal temperature reference calibration or one or more calibrated temperature reference devices, such as a blackbody reference, in view of the camera. The system then determines temperature values for each pixel within the image based on mean and median reference temperatures determined from the predetermined temperature reference or the calibrated temperature reference devices and identifies any pixels in the image having a predetermined characteristics, such as those pixels having a temperature greater than the predetermined reference temperature or some other threshold, or, alternatively, pixels in a range of temperatures. |
| FILED | Thursday, April 14, 2022 |
| APPL NO | 17/720361 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/01 (20130101) Original (OR) Class Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 5/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220241094 | Bokser et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Liberating Technologies, Inc. (Holliston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin Bokser (Flushing, New York); Kevin Keough (Sharon, Massachusetts); Aaron Taszreak (China, Michigan); Todd Farrell (Waltham, Massachusetts); Jennifer Johansson (Wayland, Massachusetts); Sangwoo Park (Moriches, New York); Kevin Lawrence (Milford, Massachusetts) |
| ABSTRACT | A prosthetic foot includes a foot portion and a switching adapter. The switching adapter includes a first member coupled to the foot portion, a second member, a third member interposed between the first member and the second member, and a locking mechanism. The third member has a first side wall and a second side wall larger in length than the first side wall. The third member is configured to rotate relative to the first member and the second member towards a first position, thereby placing the prosthetic device in a walking mode. The third member is further configured to rotate relative to the first member and the second member towards a second position, thereby placing the prosthetic device in a running mode. The locking mechanism is configured to rotate with the third member in response to rotation of the third member. |
| FILED | Tuesday, February 01, 2022 |
| APPL NO | 17/590280 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/6607 (20130101) Original (OR) Class A61F 2002/5018 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220241389 | PEOPLES et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George E. PEOPLES (Spring Branch, Texas); Sathibalan PONNIAH (Columbia, Maryland) |
| ABSTRACT | The invention features methods to induce and maintain a protective cytotoxic T-lymphocyte response to a peptide of the HER2/neu oncogene, E75, with the effect of inducing and maintaining protective or therapeutic immunity against breast cancer in a patient in clinical remission. The methods comprise administering to the patient an effective amount of a vaccine composition comprising a pharmaceutically acceptable carrier, an adjuvant such as recombinant human GM-CSF, and the E75 peptide at an optimized dose and schedule. The methods further comprise administering an annual or semi-annual booster vaccine dose due to declining E75-specific T cell immunity. The invention also features vaccine compositions for use in the methods. |
| FILED | Wednesday, January 12, 2022 |
| APPL NO | 17/574178 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 38/179 (20130101) A61K 38/193 (20130101) A61K 39/00 (20130101) A61K 39/39 (20130101) A61K 39/001106 (20180801) Original (OR) Class A61K 2039/545 (20130101) A61K 2039/55522 (20130101) Peptides C07K 14/71 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220241398 | HASHEY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GLAXOSMITHKLINE BIOLOGICALS SA (Rixensart, Belgium) |
| ASSIGNEE(S) | GLAXOSMITHKLINE BIOLOGICALS SA (RIXENSART, Belgium) |
| INVENTOR(S) | KATHRYN HASHEY (Washington, District of Columbia); PADMA MALYALA (Cambridge, Massachusetts); MARCELO SAMSA (Rockville, Maryland); OLGA SLACK (Cambridge, Massachusetts); DONG YU (Rockville, Maryland); ALAN STOKES (Rockville, Maryland); RASHMI JALAH (Rockville, Maryland) |
| ABSTRACT | Nucleic acid based vaccine constructs encoding Lyssaviral antigens are useful in preventing and treating diseases. Self-amplifying RNA molecules encoding Lyssaviral antigens provide potent and long-lasting immunity. |
| FILED | Wednesday, February 02, 2022 |
| APPL NO | 17/591421 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/127 (20130101) A61K 39/205 (20130101) Original (OR) Class A61K 2039/53 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220241750 | McGill et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | R. Andrew McGill (Lorton, Virginia); Courtney A. Roberts (Washington, District of Columbia) |
| ABSTRACT | The invention relates to strong hydrogen-bond acidic sorbents. The sorbents may be provided in a form that limits or eliminates intramolecular bonding of the hydrogen-bond acidic site between neighboring sorbent molecules, for example, by providing steric groups adjacent to the hydrogen-bond acidic site. The hydrogen bond site may be a phenolic structure based on a bisphenol architecture. The sorbents of the invention may be used in methods for trapping or detecting hazardous chemicals or explosives. |
| FILED | Thursday, April 21, 2022 |
| APPL NO | 17/725830 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/22 (20130101) Original (OR) Class B01J 20/282 (20130101) B01J 20/3425 (20130101) B01J 20/3483 (20130101) B01J 20/28023 (20130101) B01J 2220/54 (20130101) Acyclic or Carbocyclic Compounds C07C 39/367 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 14/06 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 59/00 (20130101) C08G 64/00 (20130101) C08G 64/10 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/482 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220242740 | Hersam et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark C. Hersam (Wilmette, Illinois); Xiaolong Liu (Ithaca, New York) |
| ABSTRACT | The invention relates to two dimensional (2D) heterostructures and methods of fabricating the same. The 2D hetero structures are integration of borophene with graphene and 2D lateral and vertical hetero structures with sharp and rotationally commensurate interfaces. The rich bonding configurations of boron indicate that borophene can be integrated into a diverse range of 2D heterostructures. |
| FILED | Wednesday, June 17, 2020 |
| APPL NO | 17/617367 |
| CURRENT CPC | Processes for Applying Fluent Materials to Surfaces, in General B05D 5/12 (20130101) Non-metallic Elements; Compounds Thereof; C01B 35/04 (20130101) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/20 (20130101) C01P 2002/60 (20130101) C01P 2004/90 (20130101) C01P 2006/40 (20130101) C01P 2006/90 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/04 (20130101) C23C 14/12 (20130101) C23C 14/24 (20130101) C23C 16/04 (20130101) C23C 16/22 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/06 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/008 (20130101) H01L 51/0011 (20130101) H01L 51/0053 (20130101) H01L 51/0096 (20130101) H01L 2251/301 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220242946 | Spangler et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jamie Spangler (Baltimore, Maryland); Derek VanDyke (Baltimore, Maryland) |
| ABSTRACT | This document relates to methods and materials for targeted expansion of regulatory T cells (TRegS). For example, one or more single-chain antibody/cytokine fusion proteins (immunocytokines) that can bind to a heterotrimeric receptor including an interleukin-2 receptor-α(IL-2Rα) polypeptide, an interleukin-2 receptor-β(IL-2Rβ) polypeptide, and a common gamma chain (γc) polypeptide (e.g., an IL-2Rα/IL-2Rβ/γc polypeptide complex) can be administered to a mammal to stimulate TRegS within the mammal to reduce or eliminate an immune response in that mammal. In some cases, methods and materials that can be used to treat a mammal having a condition that can benefit from reducing or eliminating an immune response within the mammal are provided. For example, one or more single-chain immunocytokines that can bind to an IL-2Rα/IL-2Rβ/γc polypeptide complex can be administered to a mammal having a condition that can benefit from reducing or eliminating an immune response to treat the mammal. |
| FILED | Friday, June 26, 2020 |
| APPL NO | 17/622504 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/2013 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/06 (20180101) Peptides C07K 14/55 (20130101) C07K 14/7155 (20130101) C07K 16/246 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220243017 | Gunckel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (SCOTTSDALE, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan Gunckel (Tempe, Arizona); Lenore Dai (Phoenix, Arizona); Aditi Chattopadhyay (Chandler, Arizona); Bonsung Koo (Tempe, Arizona) |
| ABSTRACT | Composite material can include a matrix material, a fiber dispersed in the matrix material, and an ultraviolet (UV)-light sensitive mechanophore grafted to a surface of the fiber. A method for making a fiber-reinforced polymer composite can include contacting a fiber in a first solution, rinsing and then drying intermediate fiber, contacting dried fiber in a third solution, rinsing, and then drying the rinsed fiber thereby generating functionalized fiber that is sensitive to ultraviolet light. The functionalized fiber can be combined with a polymer matrix material, cured, and irradiated, thereby generating a fiber-reinforced polymer composite. |
| FILED | Tuesday, November 16, 2021 |
| APPL NO | 17/527905 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/28 (20130101) C08J 5/08 (20130101) Original (OR) Class C08J 5/042 (20130101) C08J 2363/00 (20130101) Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 1/429 (20130101) Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220243091 | WEBSTER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NDSU RESEARCH FOUNDATION (Fargo, North Dakota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dean C. WEBSTER (Fargo, North Dakota); AliReza RAHIMI (N Royalton, Ohio) |
| ABSTRACT | The invention relates to a curable coating composition comprising at least one glycidyl carbamate (GC) resin, at least one amphiphilic GC-functional prepolymer, and at least one curing agent. The invention also relates to a method of making the curable coating compositions. The invention also relates to an article of manufacture comprising the curable coating composition of the invention and a method of making such article. The invention also relates to a fouling-release (FR) coating system and an anti-coating system, each of which comprises the curable coating compositions of the invention, methods of applying the FR coating systems and anti-coating systems to substrates, and methods for reducing or preventing biofouling or icing of a surface exposed to an aqueous environment using the FR coating systems. |
| FILED | Friday, January 29, 2021 |
| APPL NO | 17/162227 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/12 (20130101) C08G 18/61 (20130101) C08G 18/755 (20130101) C08G 18/2845 (20130101) C08G 18/4833 (20130101) C08G 18/7893 (20130101) C08G 77/16 (20130101) C08G 77/20 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/17 (20130101) C08K 5/0025 (20130101) Compositions of Macromolecular Compounds C08L 77/00 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/1637 (20130101) C09D 163/00 (20130101) C09D 175/04 (20130101) Original (OR) Class Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 3/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220243190 | Meyer |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Rochester (Rochester, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anne S. Meyer (Fairport, New York) |
| ABSTRACT | The present disclosure provides easy and cost-effective methods for 3D printing of microorganisms to form biofilms, such as genetically engineered Escherichia coli biofilms. In some embodiments, the 3D printing platform exploits simple alginate chemistry for printing of a bacteria-alginate bioink mixture onto calcium-containing agar surfaces, resulting in the formation of bacteria-encapsulating hydrogels with varying geometries. Bacteria in these hydrogels remain intact, spatially patterned, and viable for several days. Printing of engineered bacteria to produce inducible biofilms leads to formation of multilayered three-dimensional structures that can tolerate harsh chemical treatments, enabling the construction of living biofilm-derived materials in a large-scale and environmentally-stable manner. |
| FILED | Monday, July 13, 2020 |
| APPL NO | 17/626532 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 80/00 (20141201) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 11/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220244274 | Harper et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Iowa Research Foundation (Iowa City, Iowa); UNITED STATES DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Harper (Tipton, Iowa); Michael Anderson (Iowa City, Iowa); Kacie Meyer (Iowa City, Iowa); Laura M. Dutca (North Liberty, Iowa); John Manohar (Ames, Iowa); Randy Kardon (Iowa City, Iowa) |
| ABSTRACT | Disclosed here is a method of detecting traumatic brain injury in a subject, comprising collecting a biological sample from the subject; analyzing the biological sample to determine the level of at least one protein selected from ALDOA, PHKB, HBA-A1, DPYSL2, SYN1 and/or CKB; and determining whether the level of the at least one protein exceeds a predetermined threshold. In certain aspects, the method further comprises the step of administering a treatment to the subject if the at least one protein exceeds the predetermined threshold. The disclosed technology relates generally to brain injuries, and in particular to a panel of serum based biomarkers that can identify individuals with mild traumatic brain injury (TBI). |
| FILED | Wednesday, February 02, 2022 |
| APPL NO | 17/591521 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/721 (20130101) G01N 33/6896 (20130101) Original (OR) Class G01N 2333/76 (20130101) G01N 2800/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220244374 | Soltanaghaei et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elahe Soltanaghaei (Pittsburgh, Pennsylvania); Anthony Rowe (Pittsburgh, Pennsylvania); Swarun Kumar (Pittsburgh, Pennsylvania); Akarsh Prabhakara (Pittsburgh, Pennsylvania); Artur Balanuta (Pittsburgh, Pennsylvania) |
| ABSTRACT | A method of operating a frequency modulated continuous-wave radar can include transmitting CHIRP signals from a plurality of antennas of the frequency modulated continuous-wave radar, receiving, via the plurality of antennas, signals including asynchronously modulated retro-directive signals from at least one remote radio frequency tag generated responsive to the CHIRP signals, generating difference Intermediate Frequency signals from the CHIRP signals transmitted and the signals received, and performing a first transform operation on the difference Intermediate Frequency signals to detect occurrence of the asynchronously modulated retro-directive signals in the difference Intermediate Frequency signals. |
| FILED | Wednesday, February 02, 2022 |
| APPL NO | 17/591137 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/356 (20210501) G01S 13/75 (20130101) G01S 13/82 (20130101) Original (OR) Class G01S 13/931 (20130101) Antennas, i.e Radio Aerials H01Q 21/0006 (20130101) H01Q 21/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220244442 | RUBIN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Noah A. RUBIN (Cambridge, Massachusetts); Federico CAPASSO (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure provides an optical component, which may be a metasurface grating, including (a) a substrate; and (b) an array of subwavelength-spaced phase-shifting elements, which are tessellated on the substrate to produce, when illuminated with a polarized incident light, a diffracted light beam with a distinct polarization state for each of a finite number of diffraction orders, wherein the finite number is 2 or more. |
| FILED | Wednesday, October 13, 2021 |
| APPL NO | 17/500913 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 4/04 (20130101) Optical Elements, Systems, or Apparatus G02B 5/3025 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220244458 | Koch et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas L. Koch (Tucson, Arizona); Erfan M. Fard (Tucson, Arizona); Roland Himmelhuber (Tucson, Arizona); Linan Jiang (Tucson, Arizona); Stanley K.H. Pau (Tucson, Arizona); Robert A. Norwood (Tucson, Arizona); Kyungjo Kim (Tucson, Arizona) |
| ABSTRACT | A method for establishing optical coupling between spatially separated first and second planar waveguides includes arranging an optical interconnect on the first planar waveguide. The optical interconnect has first and second end portions and an intermediate portion. Each of the end portions has an inverse taper. The second planar waveguide is arranged on the optical interconnect so that the second planar waveguide overlaps with one of the inverse tapered end portions but not the other inverse tapered end portion to thereby enable an adiabatic transition of an optical signal from the first planar waveguide to the second planar waveguide via the optical interconnect. The first and second planar waveguides have different refractive indices at an operating wavelength and the optical interconnect have a higher refractive index at the operating wavelength than the refractive indices of a core of the first planar waveguide and a core of the second planar waveguide. |
| FILED | Monday, June 01, 2020 |
| APPL NO | 17/615136 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/305 (20130101) G02B 6/1221 (20130101) G02B 6/1223 (20130101) G02B 6/1228 (20130101) Original (OR) Class G02B 2006/12147 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220244490 | Lentz |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | US Gov't as represented by Secy of Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joshua Lentz (Niceville, Florida) |
| ABSTRACT | An optical focus control and method use rotations of a set of shift-invariant optical elements (Risley elements) that are fairly tolerant to optical misalignments and wobble in control systems. The Risley elements can be Risley prisms, Risley gratings, or photonic crystals that impart a fixed angular offset. Aligning at least one pair of Risley elements that are individually rotated can achieve an angular correct to light received off-axis for better detection by an optical detector, improving focus control. |
| FILED | Monday, January 03, 2022 |
| APPL NO | 17/567452 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 5/04 (20130101) G02B 7/28 (20130101) Original (OR) Class Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/139 (20130101) G02F 1/133528 (20130101) G02F 1/133607 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220244953 | JI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The George Washington University (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yuede JI (Washington, District of Columbia); Hao Howie Huang (McLean, Virginia) |
| ABSTRACT | A binary code similarity detection system that compares a target binary code to a source code by comparing the target binary code to a comparing binary generated by compiling the source code. Rather than using a comparing binary generated using a random or fixed compiling configuration, the system identifies the compiling configuration of the target binary code and compares the target binary code to a comparing binary generated using the same compiling configuration as the target binary code. The compiling configuration of the target binary code may be identified by a neural network (e.g., a graph attention network trained on attributed function call graphs of binary codes with known compiling configurations). The target binary code and the comparing binary may be compared using a graph neural network (e.g., a graph triplet loss network) that compares attributed control flow graphs of the of the target binary code and the comparing binary. |
| FILED | Friday, May 21, 2021 |
| APPL NO | 17/327351 |
| CURRENT CPC | Electric Digital Data Processing G06F 8/41 (20130101) G06F 8/751 (20130101) Original (OR) Class G06F 16/9024 (20190101) Computer Systems Based on Specific Computational Models G06N 3/084 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220245221 | Gabrys et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States Government as represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan C. Gabrys (San Diego, California); Luis M. Martinez (San Diego, California); Sunny James Fugate (San Diego, California) |
| ABSTRACT | A method for hiding information in executable code comprising: identifying a set of pairs of interchangeable instructions, wherein each pair has an instruction order of execution that is reversible without changing a functionality of the executable code; organizing the pairs into a plurality of matrices based on a set of random seeds; for each matrix, inverting a submatrix consisting of a subset of columns from each matrix to identify a subset of pairs; identifying a matrix that has full column rank on a subset of columns that is a function of the pairs' location; storing an index of the identified matrix's associated seed in a secure data storage location; and encoding data into the executable code by reversing the order of execution of the subset of pairs and treating each pair having reversed instructions as a “1” and each pair of non-reversed instructions as a “0” or vice versa. |
| FILED | Tuesday, February 02, 2021 |
| APPL NO | 17/165660 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/12 (20130101) Original (OR) Class G06F 21/44 (20130101) G06F 2221/0748 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0869 (20130101) H04L 9/0894 (20130101) H04L 9/3247 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220245773 | RAMAKRISHNAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BAE SYSTEMS Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| ASSIGNEE(S) | BAE SYSTEMS Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| INVENTOR(S) | Sowmya RAMAKRISHNAN (Kendall Park, New Jersey); AMY von HOLTEN (Billerica, Massachusetts) |
| ABSTRACT | The system and method of removing burn-in from full motion video (FMV) imagery. In some cases, the technique is a pre-processing step in a forensic or military application. The system and method identify one or more burn-in overlay areas in a full motion video image and creates a mask of the one or more burn-in overlay areas. Matched intensities are created for a plurality of pixels in a mask. In some cases, in-painting is used in a center portion of the full motion video image and order-filtering in used on a periphery of the full motion video image to create the matched intensities. |
| FILED | Friday, January 29, 2021 |
| APPL NO | 17/162988 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 5/005 (20130101) Original (OR) Class G06T 5/30 (20130101) G06T 2207/10016 (20130101) G06T 2207/10024 (20130101) Pictorial Communication, e.g Television H04N 5/21 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220246240 | Kuznetsov et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gleb Kuznetsov (Cambridge, Massachusetts); Marc J. Lajoie (Cambridge, Massachusetts); Matthieu M. Landon (Boston, Massachusetts); Michael G. Napolitano (Brookline, Massachusetts); Daniel Bryan Goodman (Cambridge, Massachusetts); Christopher J. Gregg (Melrose, Massachusetts); George M. Church (Brookline, Massachusetts); Nili Ostrov (Brookline, Massachusetts) |
| ABSTRACT | Methods and systems for designing, testing, and validating genome designs based on rules or constraints or conditions or parameters or features and scoring are described herein. A computer-implemented method includes receiving data for a known genome and a list of alleles, identifying and removing occurrences of each allele in the known genome, determining a plurality of allele choices with which to replace occurrences in the known genome, generating a plurality of alternative gene sequences for a genome design based on the known genome, wherein each alternative gene sequence comprises a different allele choice, applying a plurality of rules or constraints or conditions or parameters or features to each alternative gene sequence by assigning a score for each rule or constraint or condition or parameter or feature in each alternative gene sequence, resulting in scores for the applied plurality of rules or constraints or conditions or parameters or features, scoring each alternative gene sequence based on a weighted combination of the scores for the plurality of rules or constraints or conditions or parameters or features, and selecting at least one alternative gene sequence as the genome design based on the scoring. |
| FILED | Wednesday, April 13, 2022 |
| APPL NO | 17/719431 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/245 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1089 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/00 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/50 (20190201) G16B 35/10 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220246714 | SPANIER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Drexel University (Philadelphia, Pennsylvania); THE PENN STATE RESEARCH FOUNDATION (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan E. SPANIER (Bala Cynwyd, Pennsylvania); Aleksandr V. PLOKHIKH (Philadelphia, Pennsylvania); Matthias FALMBIGL (Philadelphia, Pennsylvania); Roman ENGEL-HERBERT (University Park, Pennsylvania); Jason LAPANO (University Park, Pennsylvania); Iryna S. GOLOVINA (Philadelphia, Pennsylvania) |
| ABSTRACT | The present disclosure provides a layering structure that permits integration of epitaxially oriented perovskite oxides, such as bismuth ferrite (BiFeO3), epitaxially oriented barium titanate (BaTiO3), epitaxially oriented (SrTiO3), or their superstructures (BTO/STO) or solid solutions, onto a Si substrate through a perovskite buffer layer. The structure can retain thermal process-sensitive dopant positions and other thermal process window-sensitive features through atomic layer deposition of an oxide perovskite. Also provided are methods of preparing these layered structures. |
| FILED | Wednesday, April 29, 2020 |
| APPL NO | 17/607726 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0228 (20130101) H01L 21/02197 (20130101) H01L 21/02304 (20130101) H01L 21/02356 (20130101) H01L 28/56 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220246865 | Dou et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Letian Dou (West Lafayette, Indiana); Ke Ma (West Lafayette, Indiana) |
| ABSTRACT | The present disclosure relates to novel perovskite solar cells, and the method of making and using the novel perovskite solar cells. More specifically, a triple cation perovskite solar cell device containing a multifunctional capping layer (MCL) of R1NH3+ and/or a thin layer of two-dimensional (2D) material of (R1NH3+)2(A+)n−1(M2+)n(X−)3n+1 on top of the commonly used ABX3 perovskite, with enhanced power conversion efficiency of 22.06% (from 19.94%) with long-term stability over 1000 hours under continuous illumination has been developed. |
| FILED | Friday, January 28, 2022 |
| APPL NO | 17/586869 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/2208 (20130101) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 9/0036 (20130101) H01G 9/2009 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0003 (20130101) H01L 51/0077 (20130101) Original (OR) Class H01L 51/441 (20130101) H01L 51/4253 (20130101) H01L 51/4293 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220246948 | DUAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Xiangfeng DUAN (Los Angeles, California); Yu HUANG (Los Angeles, California); Chengzhang WAN (Los Angeles, California); Mufan LI (Los Angeles, California) |
| ABSTRACT | Provided herein are catalyst materials comprising a catalyst support; and PtM′ nanowires affixed to the catalyst support, wherein the PtM′ nanowires include single atomic species of M′ at exterior surfaces of the PtM′ nanowires, and M′ represents at least one metal, e.g., a metal different from Pt. Also disclosed are manufacturing methods comprising: providing initial MM′ nanowires having an initial molar ratio of M:M′, wherein M is a noble metal, and M′ is a metal different from M; subjecting the initial MM′ nanowires to electrochemical dealloying to partially remove M′ and form partially dealloyed MM′ nanowires having a subsequent molar ratio of M:M′, wherein the subsequent molar ratio of M:M′ is greater than the initial molar ratio of M:M′; and affixing the partially dealloyed MM′ nanowires to a catalyst support. |
| FILED | Tuesday, April 21, 2020 |
| APPL NO | 17/605192 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 11/081 (20210101) C25B 11/089 (20210101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/921 (20130101) H01M 4/925 (20130101) Original (OR) Class H01M 12/06 (20130101) H01M 12/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220247443 | SHEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | INTELLIGENT FUSION TECHNOLOGY, INC. (Germantown, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dan SHEN (Germantown, Maryland); Khanh PHAM (Kirtland AFB, New Mexico); Tien M. NGUYEN (Yorba Linda, California); Genshe CHEN (Germantown, Maryland) |
| ABSTRACT | A system for hybrid modulation and demodulation includes a transmitter and a receiver. The transmitter is configured to receive a hybrid signal of a space-ground link system (SGLS), including a first component and a second component; perform a double sideband (DSB) modulation on the first component using a carrier frequency to obtain a first waveform; perform a single sideband (SSB) modulation on the second component using the carrier frequency to obtain a second waveform; mix the first waveform and the second waveform to generate a hybrid waveform; and transmit the hybrid waveform. The receiver is configured to receive the hybrid waveform; determine the carrier frequency; separate the first waveform and the second waveform; perform a DSB demodulation on the first waveform to obtain a first demodulated signal; and perform an SSB demodulation on the second waveform to obtain a second demodulated signal. |
| FILED | Thursday, February 04, 2021 |
| APPL NO | 17/167674 |
| CURRENT CPC | Demodulation or Transference of Modulation From One Carrier to Another H03D 1/24 (20130101) H03D 1/2254 (20130101) Transmission H04B 1/04 (20130101) H04B 1/30 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20220243164 | GARCIA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Kytopen Corporation (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paulo Andres GARCIA (Somerville, Massachusetts); Rameech MCCORMACK (Cambridge, Massachusetts); Jessica SIDO (Alton, Illinois); James HEMPHILL (Medford, Massachusetts); Harrison BRALOWER (Somerville, Massachusetts); Ross BEIGHLEY (Cambridge, Massachusetts); Cullen BUIE (Cambridge, Massachusetts); Bethany GRANT (Scituate, Massachusetts) |
| ABSTRACT | Devices, systems, and kits for cell transfection are provided. A device includes a first electrode, a second electrode, and an electroporation zone therebetween where an electrical potential difference applied to the first and second electrodes generates an electric field in the electroporation zone sufficient to transfect at least a subset of the cells in the flow path. Methods of introducing a composition into at least a portion of a plurality of cells using the devices, systems, and kits of the invention are also provided. |
| FILED | Thursday, July 02, 2020 |
| APPL NO | 17/624535 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 1/42 (20130101) C12M 35/02 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0645 (20130101) C12N 5/0646 (20130101) C12N 13/00 (20130101) C12N 15/87 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220243254 | Hung et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Combinati Incorporated (Carlsbad, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ju-Sung Hung (Palo Alto, California); Megan Dueck (Brisbane, California); Andrew Zayac (San Leandro, California) |
| ABSTRACT | The present disclose provides methods and systems for amplifying and quantifying nucleic acids and for detecting the presence or absence of a target in a sample. The methods and systems provided herein may utilize a device comprising a plurality of partitions separated from an external environment by a gas-permeable barrier. Certain methods disclosed herein involve subjecting nucleic acid molecules in the plurality of partitions to conditions sufficient to conduct nucleic acid amplification reactions. The nucleic acid molecules may be subjected to controlled heating in the plurality of partitions to generate data indicative of a melting point(s) of the nucleic acid molecules. |
| FILED | Wednesday, January 19, 2022 |
| APPL NO | 17/578942 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 3/502738 (20130101) B01L 7/52 (20130101) B01L 2200/16 (20130101) B01L 2200/0684 (20130101) B01L 2300/0816 (20130101) B01L 2300/0864 (20130101) B01L 2300/0883 (20130101) B01L 2400/049 (20130101) B01L 2400/0487 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220244172 | Gupta et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Nikira Labs Inc. (Mountain View, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Manish Gupta (Mountain View, California); Rupal Gupta (Mountain VIew, California) |
| ABSTRACT | An optical system for performing an absorption measurement of a medium sample includes a laser source configured to output a laser beam having a wavelength corresponding to an absorption region of interest; a ringdown cavity comprising a chamber configured to receive the medium sample, an input mirror at an input end, an output mirror at an output end, and an optical axis that extends through the centers of the input mirror and the output mirror; a coupling device configured to couple the laser beam through the input mirror into the chamber; and a detector optically coupled with the cavity, and configured to detect an intensity of light of the wavelength corresponding to the absorption region of interest that extends through the output mirror, wherein a cavity geometry of the cavity increases the re-entrant condition of the cavity relative to a conventional cavity comprised of two spherical mirrors. |
| FILED | Wednesday, February 03, 2021 |
| APPL NO | 17/166661 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/31 (20130101) Original (OR) Class G01N 2201/0231 (20130101) G01N 2201/0633 (20130101) G01N 2201/0636 (20130101) G01N 2201/06113 (20130101) Optical Elements, Systems, or Apparatus G02B 5/10 (20130101) G02B 27/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220246947 | Bhattacharya et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UES, INC. (Dayton, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rabi S. Bhattacharya (Dayton, Ohio); Oleg N. Senkov (Fairborn, Ohio); Prabhakar Singh (Storrs, Connecticut) |
| ABSTRACT | A High Entropy Alloy (HEA) anode for a Solid Oxide Fuel Cell (SOFC), in which the HEA anode comprises: approximately ten (˜10) atomic percent (%) to ˜35% Copper (Cu) (preferably ˜23% to ˜27% Cu, and more preferably ˜24% to ˜26% Cu); ˜10% to ˜35% Iron (Fe) (preferably ˜23% to ˜27% Fe, and more preferably ˜24% to ˜26% Fe); ˜10% to ˜35% Cobalt (Co) (preferably ˜23% to ˜27% Co, and more preferably ˜24% to ˜26% Co); ˜5% to ˜25% Nickel (Ni) (preferably ˜13% to ˜17% Ni, and more preferably ˜14% to ˜16% Ni); ˜5% to ˜20% Manganese (Mn) (preferably ˜8% to 13% Mn, and more preferably ˜9% to 11% Mn); and less than a total of ˜2% other elements as impurities (preferably less than ˜1% total of other elements or impurities, and more preferably less than ˜0.5% total of other elements or impurities), with the sum of all of the alloying elements (Cu, Fe, Co, Ni, Mn, and impurities or other elements) totaling 100%. |
| FILED | Monday, January 31, 2022 |
| APPL NO | 17/589189 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/9066 (20130101) Original (OR) Class H01M 8/12 (20130101) H01M 2008/1293 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20220240518 | Coyne et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Kathryn J. Coyne (Milford, Delaware); Yanfei Wang (Lewes, Delaware) |
| ASSIGNEE(S) | University of Delaware (Newark, Delaware) |
| INVENTOR(S) | Kathryn J. Coyne (Milford, Delaware); Yanfei Wang (Lewes, Delaware) |
| ABSTRACT | The present invention provides an algicidal composition comprising Shewanella strain IRI-160 or a filtrate of a Shewanella strain IRI-160 culture, a matrix and a medium. The Shewanella strain IRI-160 or the filtrate is immobilized to the matrix. Also provided are methods for preparing the algicidal composition and using the algicidal composition for inhibiting growth of a dinoflagellate. |
| FILED | Friday, June 26, 2020 |
| APPL NO | 17/619356 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 63/20 (20200101) Original (OR) Class Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/50 (20130101) C02F 3/348 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 11/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220245538 | Davis et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Jim Davis (Los Angeles, California); John Dyck (Newbury, Ohio); Haresh Malkani (Pittsburgh, Pennsylvania); Prakashan P. Korambath (Calabasas, California); Jonathan Wise (Chardon, Ohio) |
| ABSTRACT | Data centric smart manufacturing systems are described. In an embodiment, the data centric smart manufacturing system includes several systems providing raw data, several reusable data model profiles that ingest the raw data and contextualize the raw data, where a data model profile defines contextualized data, configurations, and data connectivity protocols for a particular type of system, and several data transformation models integrated with the data model profiles and instantiated with contextualized data to provide higher level operational insights. |
| FILED | Friday, August 21, 2020 |
| APPL NO | 17/753114 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/067 (20130101) Original (OR) Class G06Q 50/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220246419 | Leibrandt et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Ray Leibrandt (Superior, Colorado); David Brian Hume (Boulder, Colorado); Roger Charles Brown (Atlanta, Georgia); Jeffrey Aaron Sherman (Louisville, Colorado) |
| ABSTRACT | A spherical ion trap includes a substrate and an ion aperture; two RF electrodes in electrostatic communication with an ion trapping region; RF ground electrodes in electrostatic communication with the ion trapping region; and the ion trapping region bounded by opposing RF electrodes and the RF ground electrodes, such that: the ion trapping region is disposed within the ion aperture and receives ions that are selectively trapped in the ion trapping region in response to receipt of DC and RF voltages by the RF electrodes, and receipt of the DC voltages by RF ground electrodes, and the first RF electrode, the second RF electrode, the RF ground electrodes, and the ion trapping region are disposed in the same plane within the ion aperture. |
| FILED | Tuesday, February 01, 2022 |
| APPL NO | 17/590690 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 49/424 (20130101) Original (OR) Class H01J 49/4265 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20220241309 | Dickey et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of South Florida (Tampa, Florida); University of Kansas (Lawrence, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chad Dickey (Tampa, Florida); Lindsey Shelton (Tampa, Florida); Brian Blagg (Lawrence, Kansas); John Koren (Tampa, Florida); Laura Jenelle Blair (Tampa, Florida) |
| ABSTRACT | Disclosed herein are compounds and methods for inhibiting Aha1 for the treatment of tauopathies and neurodegenerative diseases. The Aha1 inhibitor may reduce the interaction between Aha1 and Hsp90. The Aha1 inhibitor may reduce aggregation of tau protein. The Aha1 inhibitor may include a compound selected from KU-177, KU-174, and KU-308. |
| FILED | Friday, April 15, 2022 |
| APPL NO | 17/722011 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/366 (20130101) A61K 31/7048 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220241334 | Hocum Stone et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government As Represented By The Department of Veterans Affairs (Washington, District of Columbia); Regents Of The University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Laura Leigh Hocum Stone (Minneapolis., Minnesota); Rosemary Frances Kelly (Minneapolis, Minnesota); Edward Oakley McFalls (Minneapolis, Minnesota); Christin Wright (Minneapolis, Minnesota) |
| ABSTRACT | Disclosed are methods of increasing cardiac function in a subject's myocardium comprising: administering a scaffold to the subject's myocardium, wherein the scaffold comprises mesenchymal stem cells (MSCs). Disclosed are methods of restoring the mitochondrial proteome in a subject's myocardium comprising: administering a scaffold to the subject's myocardium, wherein the scaffold comprises mesenchymal stem cells. Disclosed are methods of treating hibernating myocardium comprising combining surgical revascularization with attaching a scaffold comprising MSCs to myocardium. |
| FILED | Thursday, July 02, 2020 |
| APPL NO | 17/623805 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) A61L 27/58 (20130101) A61L 2430/20 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/04 (20180101) A61P 9/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220244274 | Harper et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Iowa Research Foundation (Iowa City, Iowa); UNITED STATES DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Harper (Tipton, Iowa); Michael Anderson (Iowa City, Iowa); Kacie Meyer (Iowa City, Iowa); Laura M. Dutca (North Liberty, Iowa); John Manohar (Ames, Iowa); Randy Kardon (Iowa City, Iowa) |
| ABSTRACT | Disclosed here is a method of detecting traumatic brain injury in a subject, comprising collecting a biological sample from the subject; analyzing the biological sample to determine the level of at least one protein selected from ALDOA, PHKB, HBA-A1, DPYSL2, SYN1 and/or CKB; and determining whether the level of the at least one protein exceeds a predetermined threshold. In certain aspects, the method further comprises the step of administering a treatment to the subject if the at least one protein exceeds the predetermined threshold. The disclosed technology relates generally to brain injuries, and in particular to a panel of serum based biomarkers that can identify individuals with mild traumatic brain injury (TBI). |
| FILED | Wednesday, February 02, 2022 |
| APPL NO | 17/591521 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/721 (20130101) G01N 33/6896 (20130101) Original (OR) Class G01N 2333/76 (20130101) G01N 2800/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20220244002 | Jacobs et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Bryson C. Jacobs (Quaker Hill, Connecticut); Patrick T. Irwin (El Dorado, California) |
| ABSTRACT | A thermoacoustic stack includes an outer wall which is cylindrical and has a length extending between a first end and a second end. An internal wall structure is disposed inside the outer wall. The internal wall structure includes a plurality of spaced adjacent wall surfaces extending along the length of the outer wall to provide open flow passages between the spaced adjacent wall surfaces. A first cross member extends across the outer wall at the first end and is connected to the outer wall and the internal wall structure at the first end. |
| FILED | Tuesday, December 07, 2021 |
| APPL NO | 17/544855 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 1/40 (20130101) F28F 21/062 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220245384 | Fortune et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | John Fortune (Clifton, Virginia); Brian Lewis (Washington, District of Columbia); Michelle Weinberger (Fairfax City, Virginia) |
| ABSTRACT | An example method to characterize an anomaly includes obtaining information about an item using a first mode scan and detecting whether the item contains an anomaly based on the information. The method further includes determining, responsive to detecting the anomaly, an area of interest of the item corresponding to a location of the anomaly, and determining a strategy including a procedure to obtain other information of the area of interest. The method refines a characterization of the anomaly based on the other information, and compares the characterization of the anomaly to a predetermined criterion. The method iteratively revises the strategy to perform additional available procedures, to further refine the characterization of the anomaly. When the characterization of the anomaly meets the predetermined criterion corresponding to a prohibited item, the method identifies the anomaly as prohibited. |
| FILED | Monday, June 21, 2021 |
| APPL NO | 17/353320 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/10 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00771 (20130101) Original (OR) Class G06K 9/3233 (20130101) G06K 9/6215 (20130101) G06K 9/6289 (20130101) Image Data Processing or Generation, in General G06T 7/30 (20170101) G06T 7/70 (20170101) G06T 2207/10116 (20130101) G06T 2207/30232 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20220241387 | GUERRERO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | FELICITO GUERRERO (PAIGE, Texas); LUISA N. DOMINGUES (COLLEGE STATION, Texas) |
| ABSTRACT | Antigenic polypeptides derived from a naturally occurring horn fly protein, and nucleic acid molecules encoding the polypeptides, are described. The polypeptides elicit an immune response which, in turn, produces detrimental effects in horn flies feeding on vaccinated cattle. Thus, the present disclosure provides a novel horn fly vaccine. |
| FILED | Wednesday, February 03, 2021 |
| APPL NO | 17/166433 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0003 (20130101) Original (OR) Class A61K 39/39 (20130101) A61K 2039/552 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 43/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 20220243040 | Shirzad et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sharareh Shirzad (Baton Rouge, Louisiana); Marwa M. Hassan (Baton Rouge, Louisiana) |
| ASSIGNEE(S) | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| INVENTOR(S) | Sharareh Shirzad (Baton Rouge, Louisiana); Marwa M. Hassan (Baton Rouge, Louisiana) |
| ABSTRACT | Disclosed herein is a self-healing asphalt binder composition comprising i) an asphalt binder, ii) an oxetane substituted polysaccharide, and iii) a polyurethane, as well as asphalts comprising said self-healing asphalt binder and an asphalt mixture. Also disclosed are methods of making the self-healing asphalt binder. |
| FILED | Monday, January 31, 2022 |
| APPL NO | 17/589490 |
| CURRENT CPC | Compositions of Macromolecular Compounds C08L 5/08 (20130101) Original (OR) Class C08L 75/04 (20130101) C08L 95/00 (20130101) C08L 2205/03 (20130101) C08L 2555/82 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Non-Profit Organization (NPO)
| US 20220241439 | ZHENG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jie ZHENG (Plano, Texas); Xingya JIANG (Richardson, Texas) |
| ABSTRACT | A biothiol-activatable composition is disclosed that is configured to dissociate in the presence of a concentration of biomolecules that are excreted normally by a liver of a living subject comprising a noble metal nanoparticle, a reporter molecule, a linker molecule that is conjugated to the noble metal nanoparticle and to the reporter molecule, but displaceable in the presence of the biomolecules, and wherein the reporter molecule is released in the presence of the biomolecules. The noble nanoparticle is preferably a gold nanoparticle; the reporter molecule preferably comprises at least one of a fluorescent dye molecule, a radioactive molecule or an MRI agent and the linker molecule is preferably a thiol molecule displaceable by biothiols in the liver. In another aspect, the reporter molecule dissociates from the composition in the presence of a concentration of glutathione similar to what is found in liver sinusoids of a normally functioning liver. |
| FILED | Wednesday, June 17, 2020 |
| APPL NO | 17/620312 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5115 (20130101) A61K 49/0034 (20130101) A61K 49/0093 (20130101) Original (OR) Class A61K 49/186 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/542 (20130101) G01N 33/6815 (20130101) G01N 33/54353 (20130101) G01N 2800/085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Smithsonian Institution (SI)
| US 20220240500 | Bischof et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota); SMITHSONIAN INSTITUTION (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Bischof (St. Paul, Minnesota); Kanav Khosla (Minneapolis, Minnesota); Zhenpeng Qin (Allen, Texas); Mary Margaret Hagedorn (Kaneohe, Hawaii); Cari Suzanne Dutcher (North Oaks, Minnesota) |
| ABSTRACT | A cryopreservation composition generally includes a cryoprotective agent and a laser absorber that includes a metal. Rewarming a cryopreserved specimen that includes the cryopreservation composition includes subjecting the cryopreserved specimen to a laser pulse effective to heat the laser absorber sufficiently to thaw the cryopreserved biospecimen. |
| FILED | Thursday, April 21, 2022 |
| APPL NO | 17/726271 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0221 (20130101) Original (OR) Class A01N 1/0231 (20130101) A01N 1/0294 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
U.S. State Government
| US 20220241439 | ZHENG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jie ZHENG (Plano, Texas); Xingya JIANG (Richardson, Texas) |
| ABSTRACT | A biothiol-activatable composition is disclosed that is configured to dissociate in the presence of a concentration of biomolecules that are excreted normally by a liver of a living subject comprising a noble metal nanoparticle, a reporter molecule, a linker molecule that is conjugated to the noble metal nanoparticle and to the reporter molecule, but displaceable in the presence of the biomolecules, and wherein the reporter molecule is released in the presence of the biomolecules. The noble nanoparticle is preferably a gold nanoparticle; the reporter molecule preferably comprises at least one of a fluorescent dye molecule, a radioactive molecule or an MRI agent and the linker molecule is preferably a thiol molecule displaceable by biothiols in the liver. In another aspect, the reporter molecule dissociates from the composition in the presence of a concentration of glutathione similar to what is found in liver sinusoids of a normally functioning liver. |
| FILED | Wednesday, June 17, 2020 |
| APPL NO | 17/620312 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5115 (20130101) A61K 49/0034 (20130101) A61K 49/0093 (20130101) Original (OR) Class A61K 49/186 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/542 (20130101) G01N 33/6815 (20130101) G01N 33/54353 (20130101) G01N 2800/085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20220244438 | Chandrasekar |
|---|---|
| FUNDED BY | National Geospatial-Intelligence Agency (NGA) |
| APPLICANT(S) | The United States of America As Represented By The Director Of The National Geospatial-Intelligence (Springfield, Virginia) |
| ASSIGNEE(S) | The United States of America As Represented By The Director Of The National Geospatial-Intelligence (Springfield, Virginia) |
| INVENTOR(S) | Rohith Chandrasekar (Springifeld, Virginia) |
| ABSTRACT | Systems and methods for improving night vision systems are presented. Broadband multi-level diffractive lenses are used in place of either or both of the objective and eyepiece of traditional night vision systems. By using one or more broadband multi-level diffractive lenses, the size, weight, and weight distribution may be reduced or modified. |
| FILED | Wednesday, February 03, 2021 |
| APPL NO | 17/166186 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 5/1814 (20130101) Original (OR) Class G02B 23/125 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, August 04, 2022.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20220804.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page