FedInvent™ Patent Applications
Application Details for Thursday, August 11, 2022
This page was updated on Thursday, August 11, 2022 at 11:49 AM GMT
Department of Health and Human Services (HHS)
| US 20220248663 | JAMES |
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| FUNDED BY |
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| APPLICANT(S) | Sanaria Inc. (Rockville, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric R. JAMES (Darnestown, Mississippi) |
| ABSTRACT | Herein is described a method devised to cryopreserve mosquito eggs, viable upon subsequent thawing. The method reproducibly yields >25% hatched first instar larvae of Anopheles-species mosquitoes from cryopreserved eggs. The majority of hatched larvae continue to develop normally (87% pupation), through to adults (98%, 50% of which are female) which subsequently blood feed and produce viable second generation embryos that also develop normally. Adult mosquitoes obtained from cryopreserved embryos are able to be infected with Plasmodium falciparum gametocytes and produce salivary gland sporozoites in similar numbers to control mosquitoes. |
| FILED | Monday, July 13, 2020 |
| APPL NO | 17/626381 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0339 (20130101) A01K 2207/12 (20130101) A01K 2227/706 (20130101) Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0221 (20130101) Original (OR) Class A01N 1/0284 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220248949 | Norton et al. |
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| FUNDED BY |
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| APPLICANT(S) | Health Research, Inc. (Menands, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Norton (Albany, New York); Jonathan Carp (Albany, New York); Jonathan Wolpaw (Albany, New York) |
| ABSTRACT | The present disclosure relates to a method for assessing color vision. The method includes identifying one or more steady-state visual evoked potentials (SSVEPs) to identify metamers. The present disclosure further relates to devices for assessing color vision that use metamers identified via steady-state visual evoked potentials (SSVEPs). Also disclosed herein are methods of treating color vision deficiency, systems for identifying a response to one or more metameric stimuli, methods of individually modifying color vision, methods for assessing color vision using neural activity as a means to personalize visual displays, and methods for assessing light sensitive cells in the nervous system using flashing lights. |
| FILED | Wednesday, December 08, 2021 |
| APPL NO | 17/546039 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/0008 (20130101) A61B 3/066 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220248971 | Boas et al. |
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| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Boas (Winchester, Massachusetts); Jason Sutin (Cambridge, Massachusetts); Maria Angela Franceschini (Winchester, Massachusetts) |
| ABSTRACT | Systems and methods for path length selected diffuse correlation spectroscopy (PLS-DCS) are disclosed. The systems and methods are suitable for measuring dynamics of a target medium. The systems and methods can utilize light sources having a coherence length that is shorter than a path length distribution of the target medium and can utilize a reference optical path to interferometrically detect PLS-DCS signals. The coherence length and reference path length can be selected to provide sensitivity to portions of the target medium that correspond to a desired path length distribution. |
| FILED | Friday, October 22, 2021 |
| APPL NO | 17/508718 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0075 (20130101) A61B 5/0261 (20130101) Original (OR) Class A61B 5/4064 (20130101) A61B 5/6814 (20130101) A61B 5/14551 (20130101) A61B 5/14552 (20130101) A61B 5/14553 (20130101) A61B 2562/0238 (20130101) A61B 2562/0242 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220248974 | Grissom et al. |
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| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William A. Grissom (Nashville, Tennessee); Charles F. Caskey (Nashville, Tennessee) |
| ABSTRACT | A system and method of magnetic particle imaging (MPI) are disclosed. The system and method use ultrasound to drive magnetic particles (such as nanoparticles) through a magnetic field gradient to generate a signal and map the magnetic particles' distribution or concentration. |
| FILED | Tuesday, February 08, 2022 |
| APPL NO | 17/667497 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0035 (20130101) A61B 5/0515 (20130101) Original (OR) Class A61B 8/485 (20130101) A61B 2562/0223 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 15/8906 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220248983 | Roxbury et al. |
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| APPLICANT(S) | University of Rhode Island Board of Trustees (Kingston, Rhode Island) |
| ASSIGNEE(S) | University of Rhode Island Board of Trustees (Kingston, Rhode Island) |
| INVENTOR(S) | Daniel Roxbury (Warwick, Rhode Island); Mohammad Moein Safaee (Kingston, Rhode Island); Mitchell Gravely (North Kingstown, Rhode Island) |
| ABSTRACT | An optical core-shell microfibrous textile incorporates single-walled carbon nanotubes (SWCNTs) for the real-time optical monitoring of hydrogen peroxide concentrations and other biochemicals in in vitro wounds. The environmentally sensitive and non-photo-bleachable fluorescence of SWCNTs enable continuous analyte monitoring without a decay in signal over time. The microfibrous textiles spatially resolve chemical indicator concentrations using a camera and are integrated into commercial wound bandages without significant degradation in their optical properties. |
| FILED | Tuesday, February 01, 2022 |
| APPL NO | 17/590032 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/445 (20130101) A61B 5/1455 (20130101) Original (OR) Class A61B 5/14546 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 13/00 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/041 (20170501) Compositions of Macromolecular Compounds C08L 67/04 (20130101) C08L 71/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249008 | LI et al. |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Adam LI (Thousand Oaks, California); Sridevi V. SARMA (McLean, Virginia) |
| ABSTRACT | A device may receive electroencephalography data relating to one or more cerebral regions. The device may generate, based on the electroencephalography data, a cortical stimulation mapping model of the one or more cerebral regions, wherein the cortical stimulation mapping model includes one or more virtual inputs and one or more virtual outputs corresponding to the one or more cerebral regions. The device may apply a virtual impulse to the one or more virtual inputs. The device may determine a virtual after-discharge from the one or more virtual outputs, wherein the virtual after-discharge includes information relating to an electrical response to the virtual impulse. The device may generate, based on the virtual after-discharge, an index that maps a magnitude of the virtual after-discharge to the one or more cerebral regions. The device may cause an action to be performed based on the index. |
| FILED | Friday, July 17, 2020 |
| APPL NO | 17/597211 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/372 (20210101) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 40/60 (20180101) G16H 50/20 (20180101) G16H 50/50 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249054 | PARKER et al. |
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| APPLICANT(S) | University of Rochester (Rochester, New York) |
| ASSIGNEE(S) | University of Rochester (Rochester, New York) |
| INVENTOR(S) | Kevin J. PARKER (Rochester, New York); Jihye BAEK (Rochester, New York) |
| ABSTRACT | An ultrasound study in which the reflected echoes are analyzed to determine a physical characteristic of scatterers within the volume of interest, the acoustic attenuation within the volume of interest, and the echo amplitude. These data are used to diagnose the disease state and the progression of disease. |
| FILED | Monday, January 31, 2022 |
| APPL NO | 17/649429 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/14 (20130101) Original (OR) Class A61B 8/085 (20130101) A61B 8/466 (20130101) A61B 8/483 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249226 | Badhwar et al. |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vinay Badhwar (Washington, Pennsylvania); Antonio D'Amore (Pittsburgh, Pennsylvania); Yasumoto Matsumura (Pittsburgh, Pennsylvania); William R. Wagner (Gibsonia, Pennsylvania) |
| ABSTRACT | A template for a valve construct for replacement of at least one of a mitral valve and a tricuspid valve includes at least an anterior leaflet portion and at least a posterior leaflet portion, each leaflet portion having a proximal edge, a distal edge, and side edges extending between the proximal edge and the distal edge. The template further includes a plurality of substantially straight elongated chordae portions each having a proximal end connected to the distal edge of one of the at least two leaflet portions and a distal end extending therefrom and one or more papillary muscle head portions formed at a commissure between distal ends of at least two of the plurality of chordae portions. A total width of the leaflet portions of the template is substantially equal to a circumference of a native annulus of a heart valve. |
| FILED | Wednesday, April 27, 2022 |
| APPL NO | 17/730522 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/24 (20130101) A61F 2/2409 (20130101) A61F 2/2412 (20130101) A61F 2/2415 (20130101) Original (OR) Class A61F 2/2457 (20130101) A61F 2230/0023 (20130101) A61F 2240/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249348 | Badalamente et al. |
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| APPLICANT(S) | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marie A. Badalamente (Mt. Sinai, New York); Alexander B. Dagum (Stony Brook, New York) |
| ABSTRACT | The invention relates to the discovery that collagenase injections are effective in dissolving and lysing the collagenase septa network in the skin that comprises cellulite. As such, the invention relates to methods of treating cellulite in a patient in need of such treatment comprising injecting or otherwise delivering the effective amount of purified collagenase to the collagenase septa network of cellulite in the skin. The invention also relates to the use of collagenase in the manufacture of a medicament to treat cellulite of the skin. |
| FILED | Friday, April 22, 2022 |
| APPL NO | 17/727118 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 8/66 (20130101) Original (OR) Class A61K 38/4886 (20130101) A61K 2800/30 (20130101) A61K 2800/91 (20130101) Specific Use of Cosmetics or Similar Toilet Preparations A61Q 19/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249389 | Yantasee et al. |
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| FUNDED BY |
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| APPLICANT(S) | Oregon Health and Science University (Portland, Oregon); PDX Pharmaceuticals, Inc. (Portland, Oregon) |
| ASSIGNEE(S) | Oregon Health and Science University (Portland, Oregon); PDX Pharmaceuticals, Inc. (Portland, Oregon) |
| INVENTOR(S) | Wassana Yantasee (Lake Oswego, Oregon); Worapol Ngamcherdtrakul (Portland, Oregon); Amanda Lund (Portland, Oregon); Moataz Reda (Portland, Oregon) |
| ABSTRACT | Disclosed herein are immunotherapeutic constructs comprising a delivery particle, at least one adjuvant, and one or more therapeutic agents/compounds that cause antigen release and/or modulate immunosuppressive tumor microenvironment. These immunotherapeutic constructs create adaptive immunity or anti-cancer immune response(s) that can be used, for instance, to prevent and treat broad types of cancer. Further disclosed are uses of the immunotherapeutic constructs, including to prevent and treat cancer in humans and animals. |
| FILED | Sunday, July 12, 2020 |
| APPL NO | 17/625330 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5031 (20130101) A61K 9/5115 (20130101) Original (OR) Class A61K 31/519 (20130101) A61K 35/17 (20130101) A61K 39/39 (20130101) A61K 39/39541 (20130101) A61K 45/06 (20130101) A61K 2039/55561 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 35/04 (20180101) Peptides C07K 16/32 (20130101) C07K 16/2827 (20130101) C07K 16/2863 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 15/1135 (20130101) C12N 2310/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249437 | Hildeman et al. |
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| APPLICANT(S) | CHILDREN'S HOSPITAL MEDICAL CENTER (Cincinnati, Ohio) |
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| INVENTOR(S) | David A. Hildeman (Cincinnati, Ohio); Andrew Herr (Cincinnati, Ohio); Suhas G. Kallapur (Cincinnati, Ohio); Jarek Meller (Cincinnati, Ohio); Alexander Thorman (Cincinnati, Ohio) |
| ABSTRACT | The disclosure provides compounds of Formula I and their use in methods of modulating an immune response by inhibiting BFL1, and related methods for treating and preventing diseases and disorders characterized by inflammation, especially neutrophil induced inflammation. |
| FILED | Thursday, July 09, 2020 |
| APPL NO | 17/597515 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/353 (20130101) A61K 31/382 (20130101) Original (OR) Class A61K 47/6913 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249439 | Hsieh |
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| APPLICANT(S) | Fred Hutchinson Cancer Research Center (Seattle, Washington) |
| ASSIGNEE(S) | Fred Hutchinson Cancer Research Center (Seattle, Washington) |
| INVENTOR(S) | Andrew Hsieh (Seattle, Washington) |
| ABSTRACT | Methods and compositions for treatment of prostate cancers, such as androgen receptor (AR) deficient and androgen receptor (AR) low cancers, are disclosed. The methods include administration of an agent that inhibits activity of eIF4F or an agent that disrupts the eIF4F translation-initiation complex (composed of eIF4E, eIF4A, and eIF4G). |
| FILED | Thursday, July 23, 2020 |
| APPL NO | 17/629333 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/58 (20130101) A61K 31/167 (20130101) A61K 31/277 (20130101) A61K 31/426 (20130101) A61K 31/427 (20130101) A61K 31/519 (20130101) A61K 31/4025 (20130101) Original (OR) Class A61K 31/4166 (20130101) A61K 31/4188 (20130101) A61K 31/4439 (20130101) A61K 38/09 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249457 | DEALWIS et al. |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio); TAIPEI MEDICAL UNIVERSITY (Taipei, Taiwan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chris DEALWIS (Cleveland, Ohio); Hsueh-Yun LEE (Taipei, Taiwan); Rajesh VISWANATHAN (Cleveland, Ohio); Sarah HUFF (Cleveland, Ohio) |
| ABSTRACT | A method of modulating ribonucleotide reductase activity in a neoplastic cell includes administering to the cell an amount of an oxadiazole, thiazole, diazole, triazole, or tetrazole ribonucleotide reductase modulator (RRmod), the amount being effective to inhibit neoplastic cell growth. |
| FILED | Monday, April 25, 2022 |
| APPL NO | 17/728623 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/41 (20130101) A61K 31/444 (20130101) A61K 31/4192 (20130101) A61K 31/4245 (20130101) A61K 31/4439 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249464 | Mutis et al. |
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| APPLICANT(S) | CANGET BIOTEKPHARMA, LLC (Buffalo, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tuna Mutis (Zoeterwoude, Netherlands); Lisa Holthof (Amsterdam, Netherlands); Fengzhi Li (Buffalo, New York); Xiang Ling (Amherst, New York); Jianqun Liao (Williamsville, New York) |
| ABSTRACT | Described herein, are the extended and newly discovered novel formulations of FL118 used alone or in combination with a type of cancer immunotherapy including but not be limited to, cell-based immunotherapy, antigen-based immunotherapy, cytokine-based immunotherapy, immunomodulatory therapy and other agents-based immunotherapy or their combinations in a certain way, ant sequential regimens or schedules, for cancer treatment to preclude, eliminate or reverse cancer phenotypes and treatment resistance. |
| FILED | Wednesday, July 22, 2020 |
| APPL NO | 17/629537 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 9/2018 (20130101) A61K 9/4858 (20130101) A61K 31/4745 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 47/40 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 37/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249471 | SUN et al. |
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| FUNDED BY |
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| APPLICANT(S) | Lisa R. YOUNG (Philadelphia, Pennsylvania); The Regents of the University of California (Oakland, California); Children's Hospital of Philadelphia (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California); Children's Hospital of Philadelphia (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Xin SUN (La Jolla, California); Jinhao XU (La Jolla, California); Lisa YOUNG (Philadelphia, Pennsylvania) |
| ABSTRACT | The present disclosure provides a novel animal model of NEHI, and method of preventing and/or treating a pulmonary disease, particularly the lung-based complications in NEHI, such as pulmonary edema, by targeting the PNEC product, such as the CGRP signaling. Also disclosed is the pharmaceutical composition for preventing and/or treating a pulmonary edema and/or other pulmonary disease, particularly, NEHI, comprising one or more CGRP signaling antagonist and/or inhibitor of the present disclosure. |
| FILED | Friday, June 12, 2020 |
| APPL NO | 17/618700 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0075 (20130101) A61K 9/1617 (20130101) A61K 31/499 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249473 | MA et al. |
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| FUNDED BY |
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| APPLICANT(S) | Xiaochao MA (Sewickley, Pennsylvania); Junjie ZHU (Pittsburgh, Pennsylvania); Jie LU (Wexford, Pennsylvania); UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALATH SYSTEM OF HIGHER EDUCATION (Pitsburgh, Pennsylvania) |
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| INVENTOR(S) | Xiaochao MA (Sewickley, Pennsylvania); Junjie ZHU (Pittsburgh, Pennsylvania); Jie LU (Wexford, Pennsylvania) |
| ABSTRACT | Disclosed are novel compositions and methods of using the same for the treatment of Erythropoiefic protoporphyria (EPP) and X-linked protoporphyria (XLP). Disclosed are methods and compositions related to treating Erythropoietic protoporphyria and X-linked protoporphyria. Also described are therapeutic agents that can inhibit ABCG2. For example, provided herein are therapeutic agents defined by Formula I. |
| FILED | Wednesday, May 20, 2020 |
| APPL NO | 17/612638 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4985 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) Peptides C07K 14/705 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/14 (20130101) Enzymes C12Y 306/03044 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249481 | Moussa |
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| FUNDED BY |
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| APPLICANT(S) | GEORGETOWN UNIVERSITY (Washington, District of Columbia) |
| ASSIGNEE(S) | GEORGETOWN UNIVERSITY (Washington, District of Columbia) |
| INVENTOR(S) | Charbel Moussa (Germantown, Maryland) |
| ABSTRACT | Provided herein are methods of treating or preventing a neurodegenerative disease, a myodegenerative disease or a prion disease in a subject comprising administering a tyrosine kinase inhibitor. |
| FILED | Thursday, April 14, 2022 |
| APPL NO | 17/659274 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/496 (20130101) A61K 31/506 (20130101) Original (OR) Class A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249484 | JIANG |
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| FUNDED BY |
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| APPLICANT(S) | Memorial Sloan Kettering Cancer Center (New York, New York) |
| ASSIGNEE(S) | Memorial Sloan Kettering Cancer Center (New York, New York) |
| INVENTOR(S) | Xuejun JIANG (New York, New York) |
| ABSTRACT | The present disclosure relates generally to methods for determining whether a patient diagnosed with cancer will benefit from or is predicted to be responsive to treatment with a ferroptosis-inducing therapy. These methods are based on screening a cancer patient for mutations in cadherin and/or the Merlin-Hippo-YAP signaling pathway. |
| FILED | Friday, May 15, 2020 |
| APPL NO | 17/611805 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/40 (20130101) A61K 31/44 (20130101) A61K 31/366 (20130101) A61K 31/513 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57496 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249490 | Sterman et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Sterman (Philadelphia, Pennsylvania); Steven Albelda (Philadelphia, Pennsylvania) |
| ABSTRACT | Gene therapy based combination therapy for malignant pleural mesothelioma (“MPM”) that is resistant to or recurrent after chemotherapy employing a viral vector containing a human interferon transgene, followed by standard first- or second-line cytotoxic chemotherapy. Overall survival rate was significantly higher than historical controls in the second-line group. |
| FILED | Tuesday, October 19, 2021 |
| APPL NO | 17/505364 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/415 (20130101) A61K 31/519 (20130101) Original (OR) Class A61K 31/555 (20130101) A61K 31/635 (20130101) A61K 31/7068 (20130101) A61K 33/243 (20190101) A61K 35/761 (20130101) A61K 38/21 (20130101) A61K 38/212 (20130101) A61K 39/12 (20130101) A61K 39/3955 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/4703 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2710/10343 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249504 | GLADYSHEV et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vadim GLADYSHEV (Boston, Massachusetts); Alexander TYSHKOVSKIY (Boston, Massachusetts); Anastasia SHINDYAPINA (Boston, Massachusetts) |
| ABSTRACT | The present disclosure relates to compositions and methods useful for elongating the lifespan of a subject (e.g., a mammalian subject, such as a human). Additionally or alternatively, the compositions and methods of the disclosure can be used to treat, prevent, and/or delay the onset of various geriatric syndromes in such a subject. The disclosure also provides compositions and methods that can be used to identify new interventions, such as chemical agents, lifestyle changes, or diets, that can be used to increase lifespan and to treat, prevent, and/or delay the onset of geriatric syndromes. |
| FILED | Friday, July 10, 2020 |
| APPL NO | 17/625425 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/19 (20130101) A61K 31/4184 (20130101) A61K 31/5377 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 39/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249509 | Rendl et al. |
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| FUNDED BY |
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| APPLICANT(S) | Icahn School of Medicine at Mount Sinai (New York, New York) |
| ASSIGNEE(S) | Icahn School of Medicine at Mount Sinai (New York, New York) |
| INVENTOR(S) | Michael Rendl (New York, New York); Nicholas J. Heitman (New York, New York); Rachel Sennett (New York, New York) |
| ABSTRACT | Methods and compositions useful in the prevention and treatment of hair loss. In some embodiments, compositions are applied to hair follicles to inhibit the transition of growth phases. In some embodiments, the composition is a myosin light chain kinase (MLCK) inhibitor alone, or in conjunction with other components. In some embodiments, methods are disclosed for identifying and/or selecting compositions for use in methods of preventing or treating hair loss. |
| FILED | Thursday, July 02, 2020 |
| APPL NO | 17/624792 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/58 (20130101) A61K 31/167 (20130101) A61K 31/277 (20130101) A61K 31/343 (20130101) A61K 31/366 (20130101) A61K 31/496 (20130101) A61K 31/506 (20130101) A61K 31/551 (20130101) Original (OR) Class A61K 31/553 (20130101) A61K 31/567 (20130101) A61K 31/573 (20130101) A61K 31/585 (20130101) A61K 31/5575 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249518 | Collins et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Peter L. Collins (Silver Spring, Maryland); Matthias Lingemann (Bethesda, Maryland); Shirin Munir (Potomac, Maryland) |
| ABSTRACT | Embodiments of a method for inhibiting viral infection in a subject are provided herein. In some embodiments, the method comprises administration of a competitive antagonist of ouabain binding to ATP1A1 to inhibit respiratory syncytial virus infection in the subject. |
| FILED | Wednesday, April 20, 2022 |
| APPL NO | 17/725331 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0043 (20130101) A61K 9/0078 (20130101) A61K 31/58 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249533 | Varghese et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DUKE UNIVERSITY (Durham, North Carolina) |
| ASSIGNEE(S) | DUKE UNIVERSITY (Durham, North Carolina) |
| INVENTOR(S) | Shyni Varghese (Durham, North Carolina); Yu Ru Shih (Durham, North Carolina); Jiaul Hoque (Durham, North Carolina) |
| ABSTRACT | The present disclosure relates to polymer-based biomaterials for the systemic or localized delivery of osteoanabolic molecules, and their use in methods for treating and/or preventing bone degeneration and for promoting bone regeneration. In one aspect, the present invention provides a biomaterial comprising a polymer and a bioactive molecule binding moiety. In certain embodiments of the first aspect of the invention, the bioactive molecule binding moiety is an osteoanabolic molecule binding moiety. |
| FILED | Wednesday, June 03, 2020 |
| APPL NO | 17/616499 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/0019 (20130101) A61K 31/69 (20130101) A61K 31/663 (20130101) A61K 31/7076 (20130101) Original (OR) Class A61K 47/36 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/08 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249534 | Vander Heiden et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew G. Vander Heiden (Belmont, Massachusetts); Peggy P. Hsu (Ann Arbor, Michigan); Frances Flewelling Diehl (Baltimore, Maryland); David B. Sykes (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure provides methods for inhibiting cell proliferation, inducing differentiation, and inducing replication stress in a cancer cell. The present disclosure also provides methods for treating a cancer in a patient. Various methods of the disclosure include contacting a cancer cell with, or administering to a patient having cancer, an agent that can change the internal baseline ratio of purine:pyrimidine in the cancer cell. |
| FILED | Tuesday, February 08, 2022 |
| APPL NO | 17/650298 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/505 (20130101) A61K 31/7076 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249545 | Kang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sumin Kang (Atlanta, Georgia); Jing Chen (Atlanta, Georgia) |
| ABSTRACT | This disclosure relates to methods of treating cancer comprising administering an effective amount of a platinum-based chemotherapy agent in combination with a microtubule associated serine/threonine-protein kinase (MAST) inhibitor and/or a glucocorticoid receptor binding agent and/or a hsp90 binding agent and/or other chemotherapy agents disclosed herein to a subject in need thereof. In certain embodiments, this disclosure relates to pharmaceutical compositions comprising combinations of agents disclosed herein and a pharmaceutically acceptable excipient. |
| FILED | Friday, July 10, 2020 |
| APPL NO | 17/626217 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/395 (20130101) A61K 31/555 (20130101) A61K 33/243 (20190101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249564 | Yu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | City of Hope (Duarte, California) |
| ASSIGNEE(S) | City of Hope (Duarte, California) |
| INVENTOR(S) | Jianhua Yu (Duarte, California); Michael A. Caligiuri (Duarte, California); Wenjuan Dong (Duarte, California) |
| ABSTRACT | Provided herein are methods of treating cancer in a subject including detecting an amount of PD-L1(+) natural killer (NK) cells in a biological sample from the subject and treating the subject with an anti cancer therapy. Provided herein are methods of treating cancer in a patient including isolating natural killer (NK) cells from a subject, producing a population of PD-L1(+) NK cell from the isolated NK cells, and administering the population of PD-L1(+) NK cells into the patient. |
| FILED | Wednesday, June 24, 2020 |
| APPL NO | 17/621909 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 39/39558 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Peptides C07K 16/2827 (20130101) C07K 2317/24 (20130101) C07K 2317/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0646 (20130101) C12N 2501/2312 (20130101) C12N 2501/2315 (20130101) C12N 2501/2318 (20130101) C12N 2502/30 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5047 (20130101) G01N 2333/70532 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249584 | RACANIELLO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SENECA THERAPEUTICS, INC. (Blue Bell, Pennsylvania); THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | SENECA THERAPEUTICS, INC. (Blue Bell, Pennsylvania); THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| INVENTOR(S) | Vincent R. RACANIELLO (Scotch Plains, New Jersey); Amy B. ROSENFELD (New York, New York); Paul L. HALLENBECK (Blue Bell, Pennsylvania) |
| ABSTRACT | Provided herein are compositions and methods of using Seneca Valley Virus (SVV) or a derivative thereof and an interferon type I (IFN-I) inhibiting agent comprising an mTOR inhibitor for treating a cancer in a subject. The disclosed methods particularly rely upon the expression level of an ANTXR1 and the expression level of IFN-I in the cancer from the subject. Also provided herein are methods for predicting the efficacy of an SVV treatment comprising IFN-I inhibiting agent. |
| FILED | Monday, July 20, 2020 |
| APPL NO | 17/626879 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/165 (20130101) A61K 31/553 (20130101) A61K 31/4745 (20130101) A61K 35/768 (20130101) Original (OR) Class Peptides C07K 16/2866 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2770/32032 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249597 | Dawson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ted M. Dawson (Baltimore, Maryland); Valina L. Dawson (Baltimore, Maryland); Yingfei Wang (Baltimore, Maryland); Hyejin Park (Baltimore, Maryland); Jun Liu (Baltimore, Maryland); Hanjing Peng (Baltimore, Maryland); Tae-In Kam (Baltimore, Maryland) |
| ABSTRACT | Provided herein are methods of treating a disease, such as Parkinson's disease, that is due to increased poly [ADP-ribose] polymerase 1 (PARP-1) activation, by inhibiting macrophage migration inhibitory factor (MIF) nuclease activity. |
| FILED | Friday, February 18, 2022 |
| APPL NO | 17/675875 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/12 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) A61P 25/28 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6834 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249598 | VIJAYARAGHAVAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Kent State University (Kent, Ohio) |
| ASSIGNEE(S) | Kent State University (Kent, Ohio) |
| INVENTOR(S) | Srinivasan VIJAYARAGHAVAN (Kent, Ohio); Souvik DEY (Kent, Ohio); Alaa EISA (Kent, Ohio) |
| ABSTRACT | Compositions targeting sperm calcineurin may be used as topical and reversible contraceptives. The compositions may include calcineurin inhibitors such as tacrolimus (e.g. FK506) and/or Cyclosporin A. The compositions may be gels, creams, or lotion-based formulations and may be used reversibly and locally for both males and females. |
| FILED | Wednesday, June 10, 2020 |
| APPL NO | 17/617978 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0034 (20130101) A61K 9/107 (20130101) A61K 38/13 (20130101) Original (OR) Class A61K 47/10 (20130101) A61K 47/36 (20130101) A61K 47/44 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 15/16 (20180101) A61P 15/18 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249601 | Hamorsky et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Krystal Hamorsky (Owensboro, Kentucky); Nobuyuki Matoba (Owensboro, Kentucky) |
| ABSTRACT | The disclosure provides, in various embodiments, compositions, for example, powders and pharmaceutical compositions, comprising a spray-dried formulation of a cholera toxin B subunit variant and a saccharide excipient. The disclosure also provides, in various embodiments, methods of making said compositions and methods of treating a disease or enhancing wound healing using said compositions. The disclosure further provides, in various embodiments, liquid compositions comprising a cholera toxin B subunit variant and mannitol. |
| FILED | Wednesday, February 09, 2022 |
| APPL NO | 17/650386 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 9/1623 (20130101) A61K 9/1694 (20130101) A61K 38/164 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249602 | TIZABI |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | HOWARD UNIVERSITY (Washington, District of Columbia) |
| ASSIGNEE(S) | HOWARD UNIVERSITY (Washington, District of Columbia) |
| INVENTOR(S) | Yousef TIZABI (Silver Spring, Maryland) |
| ABSTRACT | C-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) provides therapeutic effects in motor impairments associated with Parkinson disease (PD), and provides long lasting antidepressant effects, thus useful in treating and mitigating depression, particularly PD-depression co-morbid condition. A method for treating or mitigating depression, including administrating an effective amount of C-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) to a subject in need thereof. A method for treating or mitigating motor impairments associated with Parkinson's disease (PD), including administrating an effective amount of C-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) to a subject in need thereof. |
| FILED | Tuesday, April 26, 2022 |
| APPL NO | 17/729502 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 38/164 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249604 | Zuo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | St. Jude Children's Research Hospital (Memphis, Tennessee) |
| ASSIGNEE(S) | St. Jude Children's Research Hospital (Memphis, Tennessee) |
| INVENTOR(S) | Jian Zuo (Omaha, Nebraska); Fei Zheng (Memphis, Tennessee); Tetsuji Yamashita (Memphis, Tennessee); Wanda Layman (Germantown, Tennessee) |
| ABSTRACT | Methods and compositions using a nucleic acid molecule encoding an atonal-associated factor in combination with a co-transcription factor and/or inhibitor of a gene silencing complex to change the sensory perception of an animal are described. |
| FILED | Wednesday, March 16, 2022 |
| APPL NO | 17/696808 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0275 (20130101) A01K 2217/052 (20130101) A01K 2217/206 (20130101) A01K 2227/105 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0046 (20130101) A61K 31/7105 (20130101) A61K 38/1709 (20130101) Original (OR) Class A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249623 | MACLELLAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WASHINGTON (SEATTLE, Washington) |
| ASSIGNEE(S) | UNIVERSITY OF WASHINGTON (SEATTLE, Washington) |
| INVENTOR(S) | W. Robb MACLELLAN (SEATTLE, Washington); Danny EL-NACHEF (SEATTLE, Washington) |
| ABSTRACT | An expression vector capable of disrupting the silencing of cell cycle genes in adult cells, such as adult cardiac myocytes and other quiescent cells in terminally differentiated tissues, comprising: (a) a nucleic acid sequence encoding lysine-specific demethylase 4D (KDM4D); (b) a promoter that induces or effects overexpression of KDM4D, wherein the promoter is operably linked to the nucleic acid sequence; and (c) a regulatory element that inducibly represses the overexpression of KDM4D. The vector can be administered to a subject in a method for inducing tissue-specific hyperplasia in a mammal, including cardiomyocyte proliferation. The method provides for regenerative therapy, including improving cardiac function after myocardial infarct and other forms of cardiac damage. |
| FILED | Monday, April 18, 2022 |
| APPL NO | 17/659598 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 35/34 (20130101) A61K 38/00 (20130101) A61K 38/44 (20130101) Original (OR) Class A61K 48/0058 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0657 (20130101) C12N 9/0071 (20130101) Enzymes C12Y 114/11 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249624 | ZUCHNER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Miami (Miami, Florida); University of Rochester (Rochester, New York); UCL Business LTD (London, United Kingdom) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephan L. ZUCHNER (Miami, Florida); Adriana REBELO (Miami, Florida); Andrea CORTESE (London, United Kingdom); Rong Grace ZHAI (Miami, Florida); David N. HERRMANN (Rochester, New York) |
| ABSTRACT | The present disclosure relates to methods of detecting and treating inherited neuropathy. |
| FILED | Wednesday, April 13, 2022 |
| APPL NO | 17/719580 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/198 (20130101) A61K 31/352 (20130101) A61K 31/426 (20130101) A61K 31/428 (20130101) A61K 31/473 (20130101) A61K 31/499 (20130101) A61K 31/502 (20130101) A61K 31/517 (20130101) A61K 31/4184 (20130101) A61K 31/4188 (20130101) A61K 31/7105 (20130101) A61K 38/443 (20130101) Original (OR) Class A61K 38/465 (20130101) A61K 48/005 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0006 (20130101) C12N 15/86 (20130101) C12N 15/1137 (20130101) C12N 2310/11 (20130101) C12N 2750/14143 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 2600/156 (20130101) Enzymes C12Y 101/01014 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/66 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249627 | Koo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Hyun Koo (Philadelphia, Pennsylvania); Henry Daniell (Media, Pennsylvania) |
| ABSTRACT | The invention provides a method for combating biofilm, said method comprising contacting a surface at-risk for biofilm formation or a biofilm with a composition comprising an effective amount of antimicrobial peptide biofilm-degrading enzyme combinations, preferably in the form of a fusion protein. The biofilm may be on an animate or inanimate surface and both medical and non-medical uses and methods are provided. In one aspect the invention provides a composition for use in the treatment or prevention of a biofilm infection in a subject, particularly in the oral cavity. |
| FILED | Tuesday, February 15, 2022 |
| APPL NO | 17/672438 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/47 (20130101) Original (OR) Class A61K 47/36 (20130101) A61K 47/6943 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249652 | PALESE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (New York, New York) |
| ASSIGNEE(S) | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (New York, New York) |
| INVENTOR(S) | Peter PALESE (New York, New York); Adolfo GARCIA-SASTRE (New York, New York); Florian KRAMMER (New York, New York); Felix BRÖCKER (Berlin, Germany); Allen ZHENG (New York, New York); Weina SUN (New York, New York) |
| ABSTRACT | In one aspect, provided herein are mutated influenza virus neuraminidase polypeptides, wherein the mutated influenza virus neuraminidase polypeptides comprise a first cytoplasmic domain, a first transmembrane domain, a first stalk domain, and a first globular head domain of a first neuraminidase of a first influenza virus with an insertion of 15 to 45 or 1 to 50 amino acid residues in the first stalk domain of the first neuraminidase. In another aspect, provided herein is an influenza virus comprising such a mutated influenza virus neuraminidase polypeptide, a genome comprising a nucleotide sequence encoding such a mutated influenza virus neuraminidase polypeptide or both. In another aspect, provided herein is an immunogenic composition comprising such an influenza virus, and optionally an adjuvant. |
| FILED | Thursday, June 25, 2020 |
| APPL NO | 17/621816 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/145 (20130101) Original (OR) Class A61K 2039/5252 (20130101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 9/2402 (20130101) Enzymes C12Y 302/01018 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249653 | MAILLIARD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robbie B. MAILLIARD (Pittsburgh, Pennsylvania); Charles R. RINALDO, Jr. (Pittsburgh, Pennsylvania); Jan KRISTOFF (Burgettstown, Pennsylvania) |
| ABSTRACT | Disclosed herein are compositions and uses thereof for detecting HIV latency reversal, isolating cells with HIV latency reversal, treating HIV infection, and/or reversing latency in HIV infected CD4+ T cells. In some aspects, disclosed herein is a composition and uses thereof for treating HIV infection, wherein the composition comprises one or more mature monocyte-derived dendritic cells (MDGs) having an HIV peptide bound to a Class I major histocompatibility complex (MHC) molecule and a herpesvirus peptide bound to one or more Class II MHC molecules. |
| FILED | Friday, June 26, 2020 |
| APPL NO | 17/620204 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/21 (20130101) Original (OR) Class A61K 39/245 (20130101) A61K 2039/5154 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0639 (20130101) C12N 2501/24 (20130101) C12N 2501/25 (20130101) C12N 2501/2301 (20130101) C12N 2501/2306 (20130101) C12N 2710/16122 (20130101) C12N 2710/16133 (20130101) C12N 2740/16022 (20130101) C12N 2740/16033 (20130101) C12N 2740/16122 (20130101) C12N 2740/16222 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/505 (20130101) G01N 33/5091 (20130101) G01N 33/6872 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249667 | Wheatley et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Drexel University (Philadelphia, Pennsylvania); Thomas Jefferson University (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | Drexel University (Philadelphia, Pennsylvania); Thomas Jefferson University (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Margaret A. Wheatley (Media, Pennsylvania); John Robert Eisenbrey (Wayne, Pennsylvania); Brian E. Oeffinger (Philadelphia, Pennsylvania); Purva Vaidya (Flushing, New York) |
| ABSTRACT | The present invention provides methods for preparing acoustically-sensitive microbubbles. The method includes the steps of: i) preparing a first surfactant solution comprising a first micelle-forming surfactant at a concentration above the critical micelle concentration (CMC); ii) adding one or more pharmaceutical compounds in a solvent to the first surfactant solution, thereby loading the micelles with the one or more pharmaceutical compounds; iii) preparing a second surfactant solution comprising a second surfactant, wherein the second surfactant comprises one or more matrix forming surfactants; iv) adding heat to the second surfactant solution to melt the surfactant and allowing the mixture to cool under rapid stirring; v) combining the second surfactant solution with the loaded micelles; vi) purging the surfactant mixture with a purging gas; vii) agitating the purged mixture under a constant stream of the purging gas; and, viii) separating the formed microbubbles by size. |
| FILED | Friday, May 29, 2020 |
| APPL NO | 17/595709 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1075 (20130101) A61K 31/416 (20130101) A61K 41/0033 (20130101) Original (OR) Class A61K 47/14 (20130101) A61K 47/22 (20130101) A61K 47/186 (20130101) A61K 49/0082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249672 | Jeffries et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric M. Jeffries (West New York, New Jersey); Yadong Wang (Bradford Woods, Pennsylvania); Daniel Long (Pittsburgh, Pennsylvania); Noah R. Johnson (Pittsburgh, Pennsylvania) |
| ABSTRACT | Compositions are provided herein comprising a coacervate of a polycationic polymer, a polyanionic polymer, and platelet-rich plasma and/or serum, or a fraction or concentrate thereof. The composition is useful in wound healing. Compositions also are provided that comprise a hydrogel comprising TIMP-3; and a complex of a polycationic polymer, a polyanionic polymer, FGF-2 and SDF-1α embedded in the hydrogel, which is useful in treating a myocardial infarction. |
| FILED | Tuesday, November 23, 2021 |
| APPL NO | 17/533958 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/0019 (20130101) A61K 35/16 (20130101) A61K 35/19 (20130101) A61K 38/18 (20130101) A61K 38/177 (20130101) A61K 38/195 (20130101) A61K 38/1825 (20130101) A61K 47/34 (20130101) A61K 47/36 (20130101) Original (OR) Class A61K 47/42 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 15/40 (20130101) A61L 15/44 (20130101) A61L 15/225 (20130101) A61L 27/18 (20130101) A61L 27/20 (20130101) A61L 27/26 (20130101) A61L 27/52 (20130101) A61L 27/54 (20130101) A61L 27/56 (20130101) A61L 27/225 (20130101) A61L 27/3616 (20130101) A61L 31/16 (20130101) A61L 31/041 (20130101) A61L 31/042 (20130101) A61L 31/046 (20130101) A61L 31/145 (20130101) A61L 2300/25 (20130101) A61L 2300/252 (20130101) A61L 2300/414 (20130101) A61L 2300/418 (20130101) A61L 2400/04 (20130101) A61L 2430/20 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249681 | BOONS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (Athens, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Geert-Jan BOONS (Athens, Georgia); Xiuru LI (Athens, Georgia) |
| ABSTRACT | Disclosed herein are dual drug antibody drug conjugates with defined stoichiometric ratios of each drug. The conjugates disclosed herein are useful for the treatment of cancer, particularly drug resistant and multidrug resistance cancer. |
| FILED | Wednesday, June 24, 2020 |
| APPL NO | 17/621749 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/545 (20170801) A61K 47/549 (20170801) A61K 47/552 (20170801) A61K 47/6803 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249682 | YANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF UTAH RESEARCH FOUNDATION (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jiyuan YANG (Salt Lake City, Utah); Lian LI (Salt Lake City, Utah); C. Matthew PETERSON (Bountiful, Utah); Jindrich KOPECEK (Salt Lake City, Utah) |
| ABSTRACT | Described herein are biodegradable drug delivery conjugates and anti-cancer conjugates for effectively delivering anti-cancer agents to a subject. The conjugates include a single first cleavable peptide linker covalently connected to two polymeric segments, wherein at least one PD-L1 inhibitor is covalently bonded to each polymeric segment (referred to herein as “a PD-L1 inhibitor polymer conjugate”). Also described herein is the use of the PD-L1 inhibitor polymer conjugates in combination with anticancer agents to treat or prevent cancer. |
| FILED | Friday, October 16, 2020 |
| APPL NO | 17/754915 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6803 (20170801) Original (OR) Class A61K 47/6811 (20170801) A61K 47/6849 (20170801) A61K 47/6889 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249696 | Green et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jordan J. Green (Baltimore, Maryland); Kelly Rhodes (Baltimore, Maryland); Randall A. Meyer (Baltimore, Maryland); Stephany Yi Tzeng (Baltimore, Maryland) |
| ABSTRACT | Biodegradable particles for interacting with immune cells to generate an immunosuppressive effect are disclosed. The biodegradable particle comprises a polyester or polyester blend with at least one soluble protein or small molecule encapsulated within the particle and at least two types of protein attached to a surface of the particle or to a coating on the surface thereof, which can be used to induce targeting regulatory T cells (Tregs). The at least two types of protein attached to a surface of the particle or to a coating on the surface thereof include a “Signal 1” protein that binds to an immune cell and a “Signal 2” protein that acts as a co-stimulatory molecule to immune cells. The encapsulated protein can be an interleukin and/or a cytokine. Methods of their use for treating a disease or condition, including an autoimmune disease, are disclosed. |
| FILED | Friday, June 12, 2020 |
| APPL NO | 17/602932 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/436 (20130101) A61K 38/1841 (20130101) A61K 39/0008 (20130101) A61K 47/646 (20170801) A61K 47/6425 (20170801) A61K 47/6849 (20170801) A61K 47/6937 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249697 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David R. Liu (Cambridge, Massachusetts); Jonathan Ma Levy (Cambridge, Massachusetts); Wei Hsi Yeh (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein are methods of delivering “split” Cas9 protein or nucleobase editors into a cell, e.g., via a recombinant adeno-associated vims (rAAV), to form a complete and functional Cas9 protein or nucleobase editor. The Cas9 protein or the nucleobase editor is split into two sections, each fused with one part of an intein system (e.g., intein-N and intein-C encoded by the dnaE-n and dnaE-c genes, respectively). Upon co-expression, the two sections of the Cas9 protein or nucleobase editor are ligated together via intein-mediated protein splicing. Nucleic acid molecules encoding the N-terminal portion of a Cas9 protein or a nucleobase editor fused to an intein, and nucleic acid molecules encoding the C-terminal portion of a Cas9 protein or nucleobase editor, are provided. Recombinant AAV vectors (e.g, vectors comprising one or more of these nucleic acid molecules each comprising an intein) and particles for the delivery of the split Cas9 protein or nucleobase editor, compositions comprising such AAV vectors and particles, and methods of using such rAAV vectors and particles are also provided. Methods of administering such compositions and AAV particles to a subject are further provided. Cells and compositions comprising these nucleic acid molecules rAAV vectors, and rAAV particles are also provided. |
| FILED | Wednesday, May 20, 2020 |
| APPL NO | 17/613025 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/86 (20130101) C12N 15/111 (20130101) C12N 15/113 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249703 | Ting et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Allen Institute (Seattle, Washington) |
| ASSIGNEE(S) | Allen Institute (Seattle, Washington) |
| INVENTOR(S) | Jonathan Ting (Lake Forest Park, Washington); Boaz P. Levi (Seattle, Washington); Bosiljka Tasic (Seattle, Washington); John K. Mich (Seattle, Washington); Erik Hess (Issaquah, Washington); Edward Sebastian Lein (Mercer Island, Washington); Lucas T. Graybuck (Seattle, Washington); Tanya Daigle (Lake Forest Park, Washington); Hongkui Zeng (Seattle, Washington) |
| ABSTRACT | Artificial expression constructs for selectively modulating gene expression in selected central nervous system cell types are described. The artificial expression constructs can be used to selectively express synthetic genes or modify gene expression in GABAergic neurons generally; and/or GABAergic neuron cell types such as lysosomal associated membrane protein 5 (Lamp5) neurons; vasoactive intestinal polypeptide-expressing (Vip) neurons; somatostatin (Sst) neurons; and/or parvalbumin (Pvalb) neuron cell types. Certain artificial expression constructs additionally drive selective gene expression in Layer 4 and/or layer 5 intratelencephalic (IT) neurons, deep cerebellar nuclear neurons or cerebellar Purkinje cells. |
| FILED | Friday, February 14, 2020 |
| APPL NO | 17/431079 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0276 (20130101) A01K 2217/054 (20130101) A01K 2227/105 (20130101) A01K 2227/106 (20130101) A01K 2267/0393 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 48/0066 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0619 (20130101) C12N 7/00 (20130101) C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/86 (20130101) C12N 15/8509 (20130101) C12N 2015/859 (20130101) C12N 2310/20 (20170501) C12N 2750/14142 (20130101) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249741 | Celiz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam D. Celiz (Dorchester, Massachusetts); Kyle Holmberg Vining (Jamaica Plain, Massachusetts); David J. Mooney (Sudbury, Massachusetts) |
| ABSTRACT | The present invention provides methods and compositions for promoting dental tissue repair and/or regeneration, methods for promoting differentiation of dental pulp stem cells, methods for treating periodontal diseases, and methods for treating infection of a dental pulp in a subject in need thereof by contacting the tissue with a composition comprising a triacrylate capable of promoting dental pulp stem cells adhesion and/or proliferation. |
| FILED | Wednesday, December 08, 2021 |
| APPL NO | 17/545205 |
| CURRENT CPC | Dentistry; Apparatus or Methods for Oral or Dental Hygiene A61C 5/00 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 6/54 (20200101) A61K 31/27 (20130101) A61K 31/215 (20130101) A61K 31/225 (20130101) A61K 35/32 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/16 (20130101) A61L 27/52 (20130101) A61L 27/3834 (20130101) Original (OR) Class A61L 2430/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249980 | Castor |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trevor Percival Castor (Arlington, Massachusetts) |
| ASSIGNEE(S) | Trevor P. Castor (Woburn, Massachusetts) |
| INVENTOR(S) | Trevor Percival Castor (Arlington, Massachusetts) |
| ABSTRACT | This invention relates to methods of separating and purifying cannabinoids such as CBD, CBDA, Δ9-THC (THC), Δ9-THCA (THCA), CBN, CBG and others extracted from Cannabis sativa and other Marijuana biomass. These methods employ the use of segmentation chromatographic purification to establish purities in excess of 98.5%. |
| FILED | Monday, November 29, 2021 |
| APPL NO | 17/537426 |
| CURRENT CPC | Separation B01D 15/426 (20130101) B01D 15/1871 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251025 | van Dam et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | R. Michael van Dam (Sherman Oaks, California); Jia Wang (Los Angeles, California) |
| ABSTRACT | A chemical synthesis platform based on a particularly simple chip is described herein, where reactions take place atop a hydrophobic substrate patterned with a circular hydrophilic liquid trap. The overall supporting hardware (heater, rotating carousel of reagent dispensers, etc.) can be packaged into a very compact format (about the size of a coffee cup). We demonstrate the consistent synthesis of [18F]fallypride with high yield, and show that protocols optimized using a high-throughput optimization platform we have developed can be readily translated to this device with no changes or reoptimization. |
| FILED | Friday, May 22, 2020 |
| APPL NO | 17/612206 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/0093 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 9/527 (20130101) B01L 2200/025 (20130101) B01L 2300/1822 (20130101) B01L 2300/1844 (20130101) B01L 2400/049 (20130101) General Methods of Organic Chemistry; Apparatus Therefor C07B 59/001 (20130101) C07B 2200/05 (20130101) Acyclic or Carbocyclic Compounds C07C 227/16 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251045 | PARNELL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vettore, LLC (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenneth Mark PARNELL (Kaysville, Utah); John MCCALL (Boca Grande, Florida) |
| ABSTRACT | Provided herein is a method for treating a monocarboxylate transporter MCT4-mediated disorder in a subject in need thereof. The method comprises the step of administering to the subject a compound of structural Formula I and/or a salt thereof. The treatment of the monocarboxylate transporter MCT4-mediated disorder may inhibit activity of MCT4, or a mutant thereof, sometimes with at least a 100-fold selectivity for MCT4 over MCT1. |
| FILED | Wednesday, September 22, 2021 |
| APPL NO | 17/481660 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/415 (20130101) A61K 31/427 (20130101) A61K 31/4155 (20130101) A61K 31/4439 (20130101) A61K 31/5377 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 231/12 (20130101) Original (OR) Class C07D 401/06 (20130101) C07D 405/12 (20130101) C07D 409/04 (20130101) C07D 417/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251071 | Tang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Weiping Tang (Middleton, Wisconsin); Bo Wang (Middleton, Wisconsin); Suzhen Wu (Madison, Wisconsin); Ka Yang (Madison, Wisconsin) |
| ABSTRACT | Compounds of the formula: pharmaceutical compositions containing the compounds, and methods of inhibiting neoplastic cell growth using the compounds and compositions. |
| FILED | Wednesday, May 13, 2020 |
| APPL NO | 17/610896 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/496 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 401/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251085 | Hsu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| INVENTOR(S) | Ku-Lung Hsu (Charlottesville, Virginia); Adam Libby (Charlottesville, Virginia); Andy Heindel (Charlottesville, Virginia); Jeffrey W. Brulet (Glen Allen, Virginia); Boobalan Pachaiyappan (Charlottesville, Virginia) |
| ABSTRACT | Purine-derived covalent probes (e.g., halo or di-halo-substituted purine based covalent probes) and related ligands are described. The compounds can be used to identify reactive nucleophilic amino acid residues, such as reactive cysteine residues, in proteins and to modify the activity of proteins with reactive nucleophilic amino acid residues (e.g., reactive cysteine residues) via the formation of protein adducts comprising the ligands Modified proteins prepared from the probes and ligands are also described. |
| FILED | Tuesday, July 21, 2020 |
| APPL NO | 17/629303 |
| CURRENT CPC | Heterocyclic Compounds C07D 473/00 (20130101) Original (OR) Class Peptides C07K 2/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/582 (20130101) G01N 33/6815 (20130101) G01N 33/6851 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251097 | Min et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ST. JUDE CHILDRENS'S RESEARCH HOSPITAL (Memphis, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jaeki Min (Memphis, Tennessee); Jamie Jarusiewicz (Memphis, Tennessee); Marcelo Actis (Bartlett, Tennessee); Yunchao Chang (Memphis, Tennessee); Kathryn Roberts (Memphis, Tennessee); Charles Mullighan (Memphis, Tennessee); Zoran Rankovic (Memphis, Tennessee) |
| ABSTRACT | The present disclosure relates to chemical compounds that modulate cellular proliferation for the treatment of uncontrolled cellular proliferation disorders (such as cancer), pharmaceutical compositions containing such compounds, and their use in treatment. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| FILED | Thursday, July 30, 2020 |
| APPL NO | 17/629268 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 35/02 (20180101) Heterocyclic Compounds C07D 487/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251153 | CUEVAS GONZALEZ et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE GEORGE WASHINGTON UNIVERSITY (Washington, District of Columbia); RAMOT AT TEL-AVIV UNIVERSITY LTD. (Tel-Aviv, Israel) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Santiago CUEVAS GONZALEZ (Washington, District of Columbia); Pedro A. JOSE (Washington, District of Columbia); Daniel OFFEN (Tel-Aviv, Israel); Rolondo EISEN (Panama City, Panama) |
| ABSTRACT | Provided are methods for treating a renal disorder using DJ-1 related peptides and compositions thereof. |
| FILED | Friday, February 18, 2022 |
| APPL NO | 17/675910 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 13/12 (20180101) Peptides C07K 14/4702 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251157 | PEASE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (Rochester, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Larry R. PEASE (Rochester, New York); Moses RODRIGUEZ (Rochester, Minnesota) |
| ABSTRACT | Materials and methods for using multivalent molecules (e.g., antibodies) to modulate cellular function. A molecule can be targeted to a particular type of cell, either through direct binding to an epitope on the surface of the cell, or through a linker that recognizes both the multivalent molecule and a marker on the cell surface. |
| FILED | Thursday, February 17, 2022 |
| APPL NO | 17/674438 |
| CURRENT CPC | Peptides C07K 14/4726 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251160 | IRVINE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Darrell J. IRVINE (Arlington, Massachusetts); Yiran ZHENG (Cambridge, Massachusetts); Yuan ZHANG (Dorchester, Massachusetts); Brandon KWONG (Toronto, Canada) |
| ABSTRACT | The invention provides compositions and methods for, inter alia, augmenting cell-based therapies in vivo by repeatedly stimulating target cells of interest over a period of time. |
| FILED | Tuesday, November 09, 2021 |
| APPL NO | 17/522663 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/1271 (20130101) A61K 39/3955 (20130101) A61K 47/642 (20170801) A61K 47/6849 (20170801) A61K 47/6911 (20170801) A61K 47/6913 (20170801) A61K 2035/122 (20130101) Peptides C07K 14/55 (20130101) Original (OR) Class C07K 16/2803 (20130101) C07K 16/2878 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251167 | THOMAS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | St. Jude Children's Research Hospital, Inc. (Memphis, Tennessee); UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul THOMAS (Memphis, Tennessee); Jeremy CRAWFORD (Memphis, Tennessee); Allison KIRK (Memphis, Tennessee); Anthony ZAMORA (Memphis, Tennessee); Scott E. STROME (Memphis, Tennessee) |
| ABSTRACT | A vector harboring nucleic acids encoding a recombinant T cell receptor having antigenic specificity for a DnaJ heat shock protein family member B1-protein kinase cAMP-activated catalytic subunit alpha (DNAJB1-PRKACA) fusion protein is provided, as are host cells and a method for treating fibrolamellar hepatocellular carcinoma with the vector. |
| FILED | Friday, June 19, 2020 |
| APPL NO | 17/618716 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/001196 (20180801) A61K 2039/844 (20180801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/7051 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251217 | Nix et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Nix (Oakland, California); Arun Wiita (Oakland, California) |
| ABSTRACT | Provided herein are anti-CD72 nanobodies and methods of using such nanobodies for diagnostic and therapeutic purposes. |
| FILED | Thursday, July 02, 2020 |
| APPL NO | 17/623735 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Peptides C07K 16/2851 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/92 (20130101) C07K 2317/565 (20130101) C07K 2317/569 (20130101) C07K 2319/03 (20130101) C07K 2319/33 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0638 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251240 | Marks et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James D. Marks (Kensington, California); Maria Consuelo Garcia Rodriguez (San Francisco, California); Shude Yan (San Bruno, California) |
| ABSTRACT | The present disclosure provides antibodies that specifically bind to botulinum neurotoxins (e.g., BoNT/A, BoNT/B, BoNT/C, BoNT/D, BoNT/E, BoNT/F, BoNT/G, etc.) and the epitopes bound by those antibodies. The antibodies and derivatives thereof that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism. |
| FILED | Thursday, February 03, 2022 |
| APPL NO | 17/592012 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Peptides C07K 16/40 (20130101) Original (OR) Class C07K 16/1282 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/573 (20130101) G01N 33/56911 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251288 | Johnson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeremiah A. Johnson (Boston, Massachusetts); Peyton Shieh (Cambridge, Massachusetts); Keith Husted (Boston, Massachusetts); Christopher M. Brown (Boston, Massachusetts); Samantha Lynn Kristufek (Lubbock, Texas) |
| ABSTRACT | The present disclosure provides compositions comprising: a) a copolymer prepared by a method comprising polymerizing in the presence of a metathesis catalyst: i) a first monomer, wherein each instance of the first monomer is independently of the formula: or salt thereof; ii) a second monomer, wherein each instance of the second monomer is independently of the formula: or a salt thereof; iii) optionally a third monomer, wherein the third monomer is different from the first monomer and the second monomer; and iv) optionally a reprocessing catalyst; and b) optionally the reprocessing catalyst; wherein the reprocessing catalyst is a Brønsted acid, Lewis acid, Brønsted base, Lewis base, or a salt thereof; provided that the composition comprises at least one of the reprocessing catalyst of iv) and the reprocessing catalyst of b). The compositions may be reprocessed (e.g., remolded) under elevated temperature and/or elevated pressure. |
| FILED | Tuesday, November 30, 2021 |
| APPL NO | 17/538098 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 61/02 (20130101) Original (OR) Class C08G 61/12 (20130101) C08G 2261/70 (20130101) C08G 2261/314 (20130101) C08G 2261/418 (20130101) C08G 2261/3222 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251324 | Turng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lih-Sheng Turng (Madison, Wisconsin); Yiyang Xu (Madison, Wisconsin); Yu-Jyun Lin (Madison, Wisconsin); Dong-Fang Wang (Madison, Wisconsin) |
| ABSTRACT | Green, fast and easy evaporating organic solvent for use as a lubricant in the processing of polytetrafluoroethylene (PTFE) and expanded polytetrafluoroethylene (ePTFE) products and processes of using the solvents to fabricate the products are disclosed herein. The products can be used in the field of bio- and medical applications, such as for use in vascular grafts, cardiovascular and soft tissue patches, facial implants, surgical sutures, and endovascular prosthesis, and for any products known in the aerospace, electronics, fabrics, filtration, industrial and sealant arts. |
| FILED | Monday, April 25, 2022 |
| APPL NO | 17/728188 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/16 (20130101) A61L 27/56 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/092 (20130101) C08J 9/286 (20130101) Original (OR) Class C08J 2201/03 (20130101) C08J 2201/0502 (20130101) C08J 2327/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251504 | Fossati et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | New York Stem Cell Foundation, Inc. (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Valentina Fossati (New York, New York); Matthew Zimmer (New York, New York); Lilianne Barbar (New York, New York); Tanya Jain (New York, New York) |
| ABSTRACT | Described is the efficient and robust generation and isolation of functional astrocytes from pluripotent stem cells (PSCs). The methodology provided recapitulate the major steps of oligodendrocyte differentiation into mixed cell populations and subsequent isolation of astrocytes from the mixed cell populations. |
| FILED | Friday, May 29, 2020 |
| APPL NO | 17/614916 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/30 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0622 (20130101) Original (OR) Class C12N 2501/12 (20130101) C12N 2501/58 (20130101) C12N 2501/105 (20130101) C12N 2501/135 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251508 | Leen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Baylor College of Medicine (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ann Marie Leen (Houston, Texas); Juan Fernando Vera Valdes (Houston, Texas); Cliona M. Rooney (Houston, Texas); Ulrike Gerdemann (Cambridge, Massachusetts) |
| ABSTRACT | The present invention concerns methods of generating CTLs that are able to target at least one antigen from two or more viruses. The method includes exposing mixtures of peptides for different antigens to the same plurality of PBMCs and, at least in certain aspects, expanding the cells in the presence of IL4 and IL7. |
| FILED | Monday, April 18, 2022 |
| APPL NO | 17/659624 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 2039/70 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0638 (20130101) Original (OR) Class C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251509 | Rooney et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Baylor College Medicine (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cliona M. Rooney (Bellaire, Texas); Natalia Lapteva Doyle (Houston, Texas); Sandhya Sharma (Houston, Texas); Dimitrios Wagner (Houston, Texas) |
| ABSTRACT | Embodiments of the disclosure concern methods and compositions for immunotherapy for diseases and malignancies associated with viruses other than HPV or with non-virus-associated diseases and malignancies, such as wherein the VST encodes a CAR specific for a non-viral cancer and the VST can be stimulated in vitro or in vivo using viruses, viral vaccines or oncolytic viruses. In specific embodiments, methods concern production of immune cells that target one or more antigens of HIV, EBV, CMV, adenovirus, vaccinia virus, and/or VZV, including methods with stimulation steps that employ IL-7 and IL-15, but not IL-2, IL-4, or both. Other specific embodiments utilize stimulations in the presence of certain cells, such as costimulatory cells and certain antigen presenting cells. |
| FILED | Thursday, April 28, 2022 |
| APPL NO | 17/661060 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 39/12 (20130101) A61K 2039/5158 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0638 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251521 | Whitehead et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the USA as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The Government of the USA as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Stephen S. Whitehead (Bethesda, Maryland); Joseph E. Blaney (Gettysburg, Pennsylvania); Brian R. Murphy (Bethesda, Maryland); Ching-Juh Lai (Bethesda, Maryland) |
| ABSTRACT | The invention is related to a dengue virus or chimeric dengue virus that contains a mutation in the 3′ untranslated region (3′-UTR) comprising a Δ30 mutation that removes the TL-2 homologous structure in each of the dengue virus serotypes 1, 2, 3, and 4, and nucleotides additional to the Δ30 mutation deleted from the 3′-UTR that removes sequence in the 5′ direction as far as the 5′ boundary of the TL-3 homologous structure in each of the dengue serotypes 1, 2, 3, and 4, or a replacement of the 3′-UTR of a dengue virus of a first serotype with the 3′-UTR of a dengue virus of a second serotype, optionally containing the Δ30 mutation and nucleotides additional to the Δ30 mutation deleted from the 3′-UTR; and immunogenic compositions, methods of inducing an immune response, and methods of producing a dengue virus or chimeric dengue virus. |
| FILED | Tuesday, April 19, 2022 |
| APPL NO | 17/724037 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/5254 (20130101) Peptides C07K 14/005 (20130101) C07K 14/1825 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 7/045 (20130101) Original (OR) Class C12N 2770/24162 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251536 | Venditti et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Charles P. Venditti (Bethesda, Maryland); Randy J. Chandler (Bethesda, Maryland) |
| ABSTRACT | Synthetic polynucleotides encoding human propionyl-CoA carboxylase alpha (synPCCA) and exhibiting augmented expression in cell culture and/or in a subject are described herein. Adeno-associated viral (AAV) gene therapy vectors encoding synPCCA successfully rescued the neonatal lethal phenotype displayed by propionyl-CoA carboxylase alpha (Pcca−/−) deficient mice, lowered circulating methylcitrate levels in the treated animals, and resulted in prolonged hepatic expression of the product of the synPCCA transgene in vivo. |
| FILED | Friday, June 26, 2020 |
| APPL NO | 17/620331 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/53 (20130101) A61K 48/005 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/93 (20130101) Original (OR) Class C12N 15/86 (20130101) C12N 2800/22 (20130101) C12N 2830/008 (20130101) Enzymes C12Y 604/01003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251537 | Goldberg et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tony Goldberg (Madison, Wisconsin); Samuel D. Sibley (Madison, Wisconsin) |
| ABSTRACT | The disclosure relates to laboratory and bioinformatics methods for isolating, detecting, and characterizing microbes in biological samples using metagenomic approaches. |
| FILED | Monday, November 01, 2021 |
| APPL NO | 17/516596 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1003 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/6806 (20130101) C12Q 1/6853 (20130101) C12Q 1/6869 (20130101) C12Q 1/6888 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 30/00 (20190201) G16B 50/00 (20190201) G16B 50/10 (20190201) G16B 50/30 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251545 | Disney |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew D. Disney (Jupiter, Florida) |
| ABSTRACT | A method is described to define the binding of fragments onto RNA targets and to use this profiling to enable the design of small molecules targeting RNA. The method comprises exposing a labeled RNA target to a small molecule fragment appended with diazirine and an alkyne moiety. Exposure of the compounds to light produce a reactive intermediate from the diazirine moiety that will react with sites in the RNA that are proximal to the small molecule fragments binding site. The RNAs that are reacted with the fragments are captured by using a biotin azide or azide-displaying beads that react with the alkyne moiety in the presence of a Cu(I) catalyst using click chemistry. Biotinylated products are captured with streptavidin resin. The amount of labeled RNA captured by the resin/beads is measured, thereby identifying which fragments bind an RNA target. The binding site of the fragment is determined by RT-PCR. |
| FILED | Thursday, June 25, 2020 |
| APPL NO | 17/622032 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/54326 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251552 | SHEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania); Temple University - Of The Commonwealth System Of Higher Education (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hao SHEN (Philadelphia, Pennsylvania); Yan WANG (Hamilton, New Jersey); Ying TIAN (Philadelphia, Pennsylvania) |
| ABSTRACT | The present invention relates to methods and compositions comprising a miR-302 mimic/s for treatment of lung injury. The miRNA-302 mimic/s facilitate host recovery from lung injury caused due to, for example, bacterial pneumonia |
| FILED | Monday, March 23, 2020 |
| APPL NO | 17/441596 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) A61P 31/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/141 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251554 | Khvorova et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anastasia Khvorova (Westborough, Massachusetts); Neil Aronin (Newtonville, Massachusetts); Julia Alterman (Worcester, Massachusetts) |
| ABSTRACT | This disclosure relates to novel huntingtin targets. Novel oligonucleotides for the treatment of Huntington's disease are also provided. |
| FILED | Monday, November 29, 2021 |
| APPL NO | 17/536647 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0085 (20130101) A61K 31/713 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/52 (20130101) C12N 2310/315 (20130101) C12N 2310/343 (20130101) C12N 2310/344 (20130101) C12N 2310/346 (20130101) C12N 2310/3515 (20130101) C12N 2310/3517 (20130101) C12N 2310/3519 (20130101) C12N 2320/11 (20130101) C12N 2320/30 (20130101) C12N 2320/32 (20130101) C12N 2320/51 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251555 | Khvorova et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anastasia Khvorova (Westborough, Massachusetts); Julia Alterman (Worcester, Massachusetts); Sarah Davis (Boston, Massachusetts); Anton Turanov (Boston, Massachusetts) |
| ABSTRACT | Novel oligonucleotides that are fully chemically stabilized are provided. Methods of using oligonucleotides that are fully chemically stabilized are also provided. |
| FILED | Thursday, January 20, 2022 |
| APPL NO | 17/580269 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/52 (20130101) C12N 2310/315 (20130101) C12N 2310/321 (20130101) C12N 2310/322 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251559 | McNally |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE UNIVERSITY OF CHICAGO (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elizabeth McNally (Oak Park, Illinois) |
| ABSTRACT | Antisense polynucleotides and their use in pharmaceutical compositions to induce exon skipping in targeted exons of the gamma sarcoglycan gene are provided, along with methods of preventing or treating dystrophic diseases such as Limb-Girdle Muscular Dystrophy. |
| FILED | Friday, April 22, 2022 |
| APPL NO | 17/727376 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/60 (20170801) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 15/1138 (20130101) C12N 2310/11 (20130101) C12N 2320/33 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251564 | NERI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SORBONNE UNIVERSITE (Paris, France); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (Paris, France); ASSISTANCE PUBLIQUE HOPITAUX DE PARIS (Paris, France); BUCK INSTITUTE FOR RESEARCH ON AGING (Novato, California) |
| ASSIGNEE(S) | SORBONNE UNIVERSITE (Paris, France); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (Paris, France); ASSISTANCE PUBLIQUE HOPITAUX DE PARIS (Paris, France); BUCK INSTITUTE FOR RESEARCH ON AGING (Novato, California) |
| INVENTOR(S) | Christian NERI (Paris, France); Francesca FARINA (Paris, France); Jessica VOISIN (Choisy-le-Roi, France); Lisa ELLERBY (San Aselmo, California) |
| ABSTRACT | A p16INK4a inhibitor, a composition that includes the p16INK4a inhibitor, or a pharmaceutical composition that includes the p16INK4a inhibitor, for use in the prevention and/or the treatment of Huntington's disease, wherein the p16INK4a inhibitor is a nucleic acid or a peptide, a small compound molecule or a marketed drug. |
| FILED | Friday, April 17, 2020 |
| APPL NO | 17/604880 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/14 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1135 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/122 (20130101) C12N 2310/531 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251568 | Chang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jiang Chang (College Station, Texas); Weijia Luo (College Station, Texas) |
| ABSTRACT | Disclosed are RNA inhibitors, such as small interfering RNAs (siRNAs) and short hairpin RNAs (shRNAs) specific for RND3, alternatively referred to as RhoE. Also disclosed are methods of treating subjects by administering RNA inhibitors. Further disclosed are methods of detecting potential modulators of RND3. |
| FILED | Tuesday, February 09, 2021 |
| APPL NO | 17/171288 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) A61K 45/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2320/31 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/573 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251575 | Cate et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | James H. D. Cate (Berkeley, California); Dasmanthie De Silva (Berkeley, California) |
| ABSTRACT | Engineered immune cell receptor translation is modulated using heterologous noncoding sequence elements, such as modified eukaryotic initiation factor 3 (eIF3) responsive sites. |
| FILED | Thursday, April 21, 2022 |
| APPL NO | 17/726517 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/85 (20130101) C12N 15/625 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2501/2302 (20130101) C12N 2800/80 (20130101) C12N 2800/107 (20130101) C12N 2830/85 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251578 | Chang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Howard Y. Chang (Stanford, California); Chun-Kan Chen (Stanford, California) |
| ABSTRACT | Provided herein are recombinant circular RNA (circRNA) molecules comprising an internal ribosome entry site (IRES) operably linked to a protein-coding nucleic acid sequence. The IRES includes at least one RNA secondary structure element; and a sequence region that is complementary to an 18S ribosomal RNA (rRNA). Methods of producing a protein in a cell using the recombinant circRNA molecules are also provided. |
| FILED | Wednesday, March 16, 2022 |
| APPL NO | 17/696606 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/67 (20130101) Original (OR) Class C12N 15/85 (20130101) C12N 15/113 (20130101) C12N 2840/203 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251579 | Hasty et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeff Hasty (Encinitas, California); Lev Tsimring (San Diego, California); Muhammad Omar Din (San Diego, California); Arthur Prindle (San Diego, California); Sangeeta Bhatia (Lexington, Massachusetts); Tal Danino (Cambridge, Massachusetts) |
| ABSTRACT | Some embodiments described herein relate to cells which have been genetically engineered to release a polypeptide when a population of the cells reaches a desired density. In some embodiments, the released polypeptide may be a therapeutic polypeptide. In some embodiments, the therapeutic polypeptide kills tumor cells or which inhibits the growth of tumor cells. |
| FILED | Thursday, November 11, 2021 |
| APPL NO | 17/524332 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/74 (20130101) A61K 38/16 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/06 (20130101) C12N 1/20 (20130101) C12N 15/63 (20130101) C12N 15/74 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251602 | Gao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | University of Massachusetts (Boston, Massachusetts) |
| INVENTOR(S) | Guangping Gao (Westborough, Massachusetts); Phillip Tai (Worcester, Massachusetts); Elisabet C. Mandon (Shrewsbury, Massachusetts); Jianzhong Ai (Worcester, Massachusetts) |
| ABSTRACT | In some aspects, the disclosure provides recombinant AAV and nucleic acid constructs having novel inverted terminal repeats (ITRs), cap, and/or rep genes. In some aspects, the disclosure relates to gene transfer methods using rAAVs described herein. |
| FILED | Tuesday, February 01, 2022 |
| APPL NO | 17/590337 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 2750/14143 (20130101) C12N 2750/14171 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251624 | CAMPS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Manel CAMPS (Santa Cruz, California); Jennifer ALLEN (Santa Cruz, California) |
| ABSTRACT | Direct detection of mutagenesis in prokaryotes by reversion of an inactivating mutation (reversion mutation assay), producing a quantitative signal for in vivo mutagenesis, may greatly reduce the amount of test chemicals and labor involved in these assays. Further, transcriptional coupling of β-lactamase reversion and GFP, translational fusion between β-lactamase and GFP with stop codon in GFP, and a novel dual reporter to monitor continuous mutagenesis may be used in methods described herein. |
| FILED | Monday, April 25, 2022 |
| APPL NO | 17/728812 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/86 (20130101) C12N 15/72 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/34 (20130101) Original (OR) Class Enzymes C12Y 305/02006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251631 | Gomez et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts) |
| INVENTOR(S) | James Gomez (Jamaica Plain, Massachusetts); Deborah Hung (Lexington, Massachusetts); Amy Barczak (Medford, Massachusetts) |
| ABSTRACT | The specification relates generally to methods of detecting, diagnosing, and/or identifying pathogens, e.g., infectious disease pathogens and determining their drug sensitivity and appropriate methods of treatment. This invention also relates generally to methods of monitoring pathogen infection in individual subjects as well as larger populations of subjects. |
| FILED | Thursday, April 21, 2022 |
| APPL NO | 17/726278 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/025 (20130101) C12Q 1/70 (20130101) C12Q 1/689 (20130101) Original (OR) Class C12Q 1/6809 (20130101) C12Q 1/6888 (20130101) C12Q 1/6895 (20130101) C12Q 2600/112 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2333/35 (20130101) G01N 2800/52 (20130101) G01N 2800/56 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251632 | Regier et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Mary Regier (Seattle, Washington); Kelly Rose Stevens (Seattle, Washington); Sanjay Srivatsan (Seattle, Washington); Cole Trapnell (Seattle, Washington) |
| ABSTRACT | Substrates and methods for spatially resolved analyses of tissue samples are provided, allowing the data from such analyses to be mapped back to the tissue's initial architecture. For analyses that have previously been conducted on bulk, homogenized samples or on dissociated cell components not directly traceable to their prior positions in the tissue sample, spatial resolution of this data can allow better characterization of cell-cell and cell-microenvironment relationships and interactions. This spatial context can aid in determining structure-function relationships in healthy and diseased tissues may thereby enhance the scientific understanding of tissue homeostasis, development, disease, and repair. The information determined using the methods of the disclosure can also be applied to enhancing diagnostics evaluation of diseased tissues. |
| FILED | Wednesday, July 22, 2020 |
| APPL NO | 17/629255 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6816 (20130101) Original (OR) Class C12Q 1/6876 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/533 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251640 | AIDEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); BAYLOR COLLEGE OF MEDICINE (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Erez AIDEN (Houston, Texas); Elena STAMENOVA (Cambridge, Massachusetts); Andreas GNIRKE (Cambridge, Massachusetts); Eric S. LANDER (Cambridge, Massachusetts); Neva DURAND (Houston, Texas); Olga DUDCHENKO (Houston, Texas) |
| ABSTRACT | Methods for analyzing spatial proximity and epigenetic profile of nucleic acids in cells, the method comprising: fragmenting the nucleic acids, the fragmented nucleic acids comprising overhanging ends; filling in the overhanding ends with one or more labeled nucleotides; joining the filled in ends to create one or more end-joined nucleic acid fragments with one or more junctions; treating the end-joined nucleic acid fragments with bisulfite; isolating the bisulfite-treated end-joined nucleic acid fragments using the label; and determining sequence at the one or more junctions in the bisulfite treated end-joined nucleic acid fragments, thereby determining spatial proximity between the nucleic acids and the methylation profile of the nucleic acids. |
| FILED | Monday, May 18, 2020 |
| APPL NO | 17/612160 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6869 (20130101) Original (OR) Class C12Q 2600/154 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251642 | Church et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George M. Church (Brookline, Massachusetts); Richard C. Terry (Carlisle, Massachusetts); Frederic Vigneault (Ashland, Massachusetts); Francois Vigneault (Medford, Massachusetts) |
| ABSTRACT | A method of sequencing nucleic acids is provided using sequencing by ligation and/or sequencing by hybridization. |
| FILED | Friday, April 08, 2022 |
| APPL NO | 17/716016 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) Original (OR) Class C12Q 1/6874 (20130101) C12Q 1/6876 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251646 | Xie et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaoliang Sunney Xie (Lexington, Massachusetts); Katsuyuki Shiroguchi (Arlington, Massachusetts); Peter A. Sims (Cambridge, Massachusetts); Tony Z. Jia (Cambridge, Massachusetts) |
| ABSTRACT | Methods and compositions for digital profiling of nucleic acid sequences present in a sample are provided. |
| FILED | Wednesday, April 13, 2022 |
| APPL NO | 17/719800 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6853 (20130101) C12Q 1/6874 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251651 | EBERT et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (BOSTON, Massachusetts) |
| ASSIGNEE(S) | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (BOSTON, Massachusetts) |
| INVENTOR(S) | BENJAMIN LEVINE EBERT (BOSTON, Massachusetts); QUINLAN SIEVERS (BOSTON, Massachusetts) |
| ABSTRACT | In one aspect, the present invention features method of identifying a cell resistant to a modulator of Cereblon (CRBN). In another aspect, the present invention features a method of characterizing sensitivity of a subject to a modulator of CRBN. In yet another aspect, the present invention features a method of monitoring sensitivity of a subject to a modulator of CRBN. |
| FILED | Friday, September 09, 2016 |
| APPL NO | 15/759159 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/45 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6881 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251656 | Rotter et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CEDARS-SINAI MEDICAL CENTER (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jerome I. Rotter (Los Angeles, California); Marla Dubinsky (Los Angeles, California); Stephan R. Targan (Santa Monica, California); Kent D. Taylor (Ventura, California) |
| ABSTRACT | The present invention relates to methods of prognosing responsiveness to anti-TNFα therapy by determining the presence or absence of risk factors in the individual. In one embodiment, the risk factors are genetic markers, serological markers and/or clinical phenotypes associated with non-responsiveness to treatment with anti-TNFα therapy in an individual diagnosed with IBD. |
| FILED | Tuesday, December 14, 2021 |
| APPL NO | 17/551028 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) C12Q 2600/172 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251660 | Ellinor et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Bayer Aktiengesellschaft (Leverkusen, Germany); The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Patrick T. Ellinor (Cambridge, Massachusetts); Mark Chaffin (Cambridge, Massachusetts); Amer-Denis Akkad (Brookline, Massachusetts); Christian Stegmann (Wallisellen, Switzerland); Irinna Papangeli (Larkspur, California) |
| ABSTRACT | Provided herein are methods for diagnosing cardiomyopathy by evaluating a sample from a subject for the presence of a population of activated fibroblasts comprising a particular genetic signature (e.g., a genetic signature comprised of differential expression of one or more gene products relative to a normal subject or a population of normal subjects). The one or more gene products may include POSTN, COL22A1, and/or THBS4. Also provided herein are methods for treating cardiomyopathy and for modulating the activity of one or more gene products associated with activation of cardiac fibroblasts in a subject using an agent. Compositions comprising an agent for treating cardiomyopathy and kits for diagnosing cardiomyopathy are also provided by the present disclosure. |
| FILED | Friday, February 11, 2022 |
| APPL NO | 17/669904 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/33 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) C12Q 1/6883 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251662 | Condeelis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Albert Einstein College of Medicine (Bronx, New York); Massachusetts Institute of Technology (Cambridge, Massachusetts); IFO-Regina Elena Cancer Institute (Rome, Italy) |
| ASSIGNEE(S) | Albert Einstein College of Medicine (Bronx, New York); Massachusetts Institute of Technology (Cambridge, Massachusetts); IFO-Regina Elena Cancer Institute (Rome, Italy) |
| INVENTOR(S) | John S. Condeelis (Bronx, New York); Sumanta Goswami (Larchmont, New York); Frank Gertler (Boston, Massachusetts); Paola Nistico (Rome, Italy) |
| ABSTRACT | Methods and kits for diagnosis, prognosis and treatment of metastatic tumors are provided where the metastatic tumor is characterized by changes in expression of +++, ++ and/or 11a variants of Mena. |
| FILED | Thursday, September 16, 2021 |
| APPL NO | 17/477327 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/112 (20130101) C12Q 2600/136 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5011 (20130101) G01N 33/57415 (20130101) G01N 33/57419 (20130101) G01N 33/57434 (20130101) G01N 33/57438 (20130101) G01N 33/57496 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251664 | Kurtz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | David M. Kurtz (San Francisco, California); Maximilian Diehn (San Carlos, California); Arash Ash Alizadeh (San Mateo, California) |
| ABSTRACT | Processes and materials to detect cancer from a biopsy are described. In some cases, cell-free nucleic acids can be sequenced, and the sequencing result can be utilized to detect sequences derived from a neoplasm. Detection of somatic variants occurring in phase can indicate the presence of cancer in a diagnostic scan and a clinical intervention can be performed. |
| FILED | Wednesday, December 29, 2021 |
| APPL NO | 17/646472 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220252574 | Sokoloski et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin Joseph Sokoloski (Crestwood, Kentucky); V Douglas Landers (Louisville, Kentucky) |
| ABSTRACT | Immunomodulatory compositions that include at least one alphavirus capsid protein and methods of using such immunomodulatory compositions. In one aspect, methods of immunomodulating IL-1/TLR signaling in a cell are provided. Such methods typically include contacting the cell with an alphavirus capsid protein or a portion thereof, thereby immunomodulating IL-1/TLR signaling in the cell. |
| FILED | Wednesday, July 22, 2020 |
| APPL NO | 17/629309 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/02 (20180101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0687 (20130101) C12N 15/86 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5008 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220252584 | Ban et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Deependra Kumar Ban (San Diego, California); Ratnesh Lal (La Jolla, California); Gennadi Glinskii (La Jolla, California); Prabhakar R. Bandaru (San Diego, California); Sunil Srivastava (La Jolla, California); Scott John (Los Angeles, California); Tyler Bodily (La Jolla, California); Abhijith Karkisaval Ganapati (La Jolla, California) |
| ABSTRACT | Methods, systems and devices for detecting the presence of a pathogen, for example, a virus (e.g., SARS-CoV-2), or its molecular components, in health care-related samples and/or environmental samples are disclosed. An example system for improving detection of a pathogen includes biosensor device comprising a detection chip and at least one probe that specifically recognizes a pathogen, where the detection chip comprises a graphene field-effect transistor (FET) chip and the probe, which comprises an aptamer, specifically binds to a DNA, RNA, or protein associated with the pathogen. |
| FILED | Monday, January 31, 2022 |
| APPL NO | 17/649554 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5438 (20130101) Original (OR) Class G01N 33/56983 (20130101) G01N 2333/165 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220252594 | Budd et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Vermont and State Agricultural College (Burlington, Vermont) |
| ASSIGNEE(S) | The University of Vermont and State Agricultural College (Burlington, Vermont) |
| INVENTOR(S) | Ralph C. Budd (Hinesburg, Vermont); Cheryl Collins (Burlington, Vermont) |
| ABSTRACT | Provided herein are compositions and methods relating to γδ T cells. Specifically, methods of screening samples for human γδ T cells surface ligands using a soluble human γδ T cell receptor tetramer are provided. Such ligands may be useful in the treatment of diseases, for example, cancer. |
| FILED | Wednesday, May 27, 2020 |
| APPL NO | 17/613568 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/00 (20130101) Peptides C07K 14/7051 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/566 (20130101) Original (OR) Class G01N 2333/7051 (20130101) G01N 2500/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220252600 | NEWMAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MOREHOUSE SCHOOL OF MEDICINE (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gale W. NEWMAN (Duluth, Georgia); Sam ANYANWU (Atlanta, Georgia) |
| ABSTRACT | A method for diagnosing hepatitis virus infection or a hepatitis disease condition in a subject based on hepatitis virus-associated biomarkers present on exosomes in a bodily fluid sample from the subject is disclosed. Also disclosed are a method for monitoring the course of a hepatitis virus infection or a hepatitis disease condition in a subject and a method for monitoring effectiveness of treatment to a subject with an anti-hepatitis virus agent based on hepatitis virus-associated biomarkers present on exosomes in bodily fluid samples from the subject, as well as a kit for diagnosing hepatitis virus infection and/or a hepatitis disease condition in a subject based on hepatitis virus-associated biomarkers on exosomes in bodily fluid samples from the subject. |
| FILED | Wednesday, March 30, 2022 |
| APPL NO | 17/657296 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/70 (20130101) C12Q 1/703 (20130101) C12Q 1/706 (20130101) C12Q 1/707 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/40 (20130101) G01N 33/493 (20130101) G01N 33/576 (20130101) G01N 33/6893 (20130101) G01N 33/56983 (20130101) G01N 33/56988 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220252606 | Chaudhary |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Preet M. Chaudhary (Toluca Lake, California) |
| ABSTRACT | Described herein are methods for assessing cytotoxicity of an agent. The methods include providing a target cell that has been engineered to express intracellularly a reporter that is not expressed endogenously by the target cell, exposing the target cell to an agent capable of modulating cytotoxicity and assaying the activity of the reporter, wherein a change in reporter activity relative to a reference value is indicative of the agent being able to modulate cytotoxicity of the target cell. |
| FILED | Monday, April 18, 2022 |
| APPL NO | 17/723284 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/44 (20130101) C12Q 1/66 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/502 (20130101) G01N 33/581 (20130101) Original (OR) Class G01N 33/582 (20130101) G01N 33/5014 (20130101) G01N 33/5017 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220252607 | Chiu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington); Clemson University Research Foundation (Clemson, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel T. Chiu (Seattle, Washington); Changfeng Wu (Changchun, China PRC); Jason McNeill (Clemson, South Carolina); Jiangbo Yu (Bothell, Washington) |
| ABSTRACT | The present invention provides, among other aspects, functionalized chromophoric polymer dots comprising a hydrophobic core and a hydrophilic cap, and bioconjugates thereof. Also provided are improved methods for preparing functionalized chromophoric polymer dots. Methods for in vivo imaging and molecular labeling are also disclosed. |
| FILED | Tuesday, February 15, 2022 |
| APPL NO | 17/672586 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/582 (20130101) G01N 33/587 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220252612 | MERBL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Yifat MERBL (Jamaica Plain, Massachusetts); Marc W. Kirschner (Newton, Massachusetts) |
| ABSTRACT | Methods for the large scale identification of post-translational modification states of proteins and enzyme activities for carrying out post-translational modification reactions involve the analysis of functional extracts from fresh and frozen samples using protein arrays. The methods and kits of the present invention can be used to analyze and characterize compounds for their effects on post-translational modifications and their pathways. The methods and kits can also be used to diagnose and characterize a wide variety of diseases and medical conditions, including cancer, neurodegenerative diseases, immune diseases, infectious diseases, genetic diseases, metabolic conditions, and drug effects using cells or body fluids of a patient. |
| FILED | Monday, April 18, 2022 |
| APPL NO | 17/722956 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6842 (20130101) G01N 33/6845 (20130101) Original (OR) Class G01N 33/57484 (20130101) G01N 2440/00 (20130101) G01N 2440/14 (20130101) G01N 2440/36 (20130101) G01N 2800/00 (20130101) G01N 2800/28 (20130101) G01N 2800/2821 (20130101) G01N 2800/2835 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220252616 | GOLDMAN et al. |
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| FUNDED BY |
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| APPLICANT(S) | Georgetown University (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Radoslav GOLDMAN (Reston, Virginia); Miloslav SANDA (Arlington, Virginia) |
| ABSTRACT | Provided is a sensitive and specific LC-MS-MRM quantification method that distinguishes outer-arm and core fucosylated configurations of N-glycopeptides. Advantage is taken of limited fragmentation of the glycopeptides at low collision energy (collision-induced dissociation) CID to produce linkage-specific Y-ions. These ions are selected as multiple reaction monitoring (MRM) transitions for the quantification of the outer-arm and total fucosylation of 23 glycoforms of 9 glycopeptides in 7 plasma proteins. The method permits quantification of the glycoforms directly in plasma or serum without fractionation of samples or glycopeptide enrichment. A pilot study of fucosylation in liver cirrhosis of hepatitis C vims (HCV) and non-alcoholic steatohepatitis (NASH) etiologies demonstrated that liver cirrhosis is consistently associated with increased outer-arm fucosylation of a majority of the analyzed proteins. The outer-arm fucosyaltion of the A2G2F1 glycoform of the VDKDLQSLEDILHQVENK peptide of fibrinogen was found to increase more than 10-fold in the cirrhosis patients compared to healthy controls. |
| FILED | Thursday, June 11, 2020 |
| APPL NO | 17/618802 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6842 (20130101) G01N 33/6848 (20130101) G01N 33/6893 (20130101) Original (OR) Class G01N 2333/75 (20130101) G01N 2440/38 (20130101) G01N 2800/085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220252619 | KHOSHBOUEI |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Habibeh KHOSHBOUEI (Gainesville, Florida) |
| ABSTRACT | Provided herein are novel assays for detecting mediators of dopamine transmission. Specifically exemplified, are assays for detecting tyrosine hydroxylase in human monocytes. Also disclosed is the use of assays for detecting or diagnosing Parkinson's disease or severity thereof. |
| FILED | Monday, July 27, 2020 |
| APPL NO | 17/630321 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/30 (20130101) G01N 33/6896 (20130101) Original (OR) Class G01N 2800/2835 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220252684 | Rispoli et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph Vincent Rispoli (West Lafayette, Indiana); Jana M. Vincent (West Lafayette, Indiana) |
| ABSTRACT | An apparatus for detecting RF signals in magnetic resonance testing procedure includes a multidirectional stretchable fabric and a flexible radio frequency (RF) coil. The flexible RF coil has a coil shape, and comprises conductive fiber stitched into the stretchable fabric in a plurality of repeating, non-linear stitch patterns. The plurality of stitch patterns collectively define the coil shape. |
| FILED | Tuesday, May 12, 2020 |
| APPL NO | 17/610929 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/34 (20130101) Original (OR) Class G01R 33/385 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220253076 | Cleland-Huang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Notre Dame du Lac (South Bend, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jane Cleland-Huang (South Bend, Indiana); Michael Vierhauser (South Bend, Indiana); Ankit Agrawal (South Bend, Indiana) |
| ABSTRACT | A method for configuring a multiple autonomous drone mission includes displaying, a plurality of queries on a display of the computing device. The method further includes receiving, via a user interface, a plurality of inputs responsive to the plurality of queries. At least a first input of the plurality of inputs specifies a type of mission to be performed and at least a second input of the plurality of inputs specifies a geographical area in which a mission to be performed will be carried out. The method further includes automatically determining, based on the plurality of inputs, an initial location to move to for each of a plurality of drones available for implementing the mission. The method further includes automatically determining, based on the plurality of inputs, a series of tasks for each of the plurality of drones. |
| FILED | Friday, January 07, 2022 |
| APPL NO | 17/571449 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 39/024 (20130101) B64C 2201/126 (20130101) B64C 2201/127 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/104 (20130101) Original (OR) Class Wireless Communication Networks H04W 4/029 (20180201) H04W 4/30 (20180201) H04W 4/90 (20180201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220253992 | Buckler et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Elucid Bioimaging Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Elucid Bioimaging Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Andrew J. Buckler (Boston, Massachusetts); Changguo Ji (Lexington, Massachusetts); Murali Ayyapillai (Acton, Massachusetts) |
| ABSTRACT | Systems and methods for improving soft tissue contrast, characterizing tissue, classifying phenotype, stratifying risk, and performing multi-scale modeling aided by multiple energy or contrast excitation and evaluation are provided. The systems and methods can include single and multi-phase acquisitions and broad and local spectrum imaging to assess atherosclerotic plaque tissues in the vessel wall and perivascular space. |
| FILED | Thursday, December 30, 2021 |
| APPL NO | 17/566439 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/463 (20130101) A61B 6/482 (20130101) A61B 6/504 (20130101) A61B 6/4241 (20130101) A61B 6/5247 (20130101) Image Data Processing or Generation, in General G06T 5/50 (20130101) Original (OR) Class G06T 7/0012 (20130101) G06T 7/174 (20170101) G06T 2207/10081 (20130101) G06T 2207/10088 (20130101) G06T 2207/10132 (20130101) G06T 2207/20216 (20130101) G06T 2207/20224 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220254016 | Hoffman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Iowa Research Foundation (Iowa City, Iowa) |
| ASSIGNEE(S) | University of Iowa Research Foundation (Iowa City, Iowa) |
| INVENTOR(S) | Eric Alfred Hoffman (Iowa City, Iowa); Seyed Mohammad Amin Motahari Bidgoli (Lynnwood, Washington); Changhyun Lee (Iowa City, Iowa); Joseph Marion Reinhardt (Iowa City, Iowa) |
| ABSTRACT | A method for imaging a lung of a patient is provided. The method includes acquiring a full inspiration computed tomography (CT) scan of the lung to provide a total lung capacity (TLC) image and acquiring a functional residual capacity contrast enhanced multi-energy CT scan of the lung. The method further includes processing the functional residual capacity contrast enhanced multi-energy CT scan of the lung to generate a perfused blood volume (PBV) image and a virtual non-contrast (VNC) image. The method further includes registering the TLC image to at least one of the PBV and VNC images so as to provide a map of regional ventilation and to co-register local ventilation with blood perfusion, generating a lung performance metric using the co-registered images, and outputting the lung performance metric at a user interface of a computing device. |
| FILED | Monday, May 11, 2020 |
| APPL NO | 17/608433 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/032 (20130101) A61B 6/5217 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 7/30 (20170101) G06T 2207/10081 (20130101) G06T 2207/30061 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220254024 | CASTRO-GONZALEZ et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); Universidad Politecnica De Madrid (Madrid, Spain) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); Universidad Politecnica De Madrid (Madrid, Spain) |
| INVENTOR(S) | Carlos CASTRO-GONZALEZ (Cambridge, Massachusetts); Ian BUTTERWORTH (Somerville, Massachusetts); Aurelien BOURQUARD (Madrid, Spain); Alvaro Sanchez FERRO (Madrid, Spain); Jason TUCKER-SCHWARTZ (Melrose, Massachusetts); Alberto PABLO TRINIDAD (Madrid, Spain); MARIA J. LEDESMA CARBAYO (Madrid, Spain); Tom Vettenburg (Dundee, United Kingdom) |
| ABSTRACT | A system for non-invasive hematological measurements includes a platform to receive a body portion of a user and an imaging device to acquire a set of images of a capillary bed in the body portion. For each image, a controller detects one or more capillaries in the body portion of the finger to identify a first set of capillaries by estimating one or more attributes of each capillary (e.g., structural attributes, flow attributes, imaging attributes, or combinations thereof), wherein at least one attribute of each capillary meets a predetermined criterion. The controller also identifies a second set of capillaries from the first set of capillaries such that each capillary of the second set of capillaries is visible in a predetermined number of images of the set of images. |
| FILED | Monday, February 07, 2022 |
| APPL NO | 17/666461 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0261 (20130101) A61B 5/489 (20130101) A61B 5/1455 (20130101) A61B 5/6826 (20130101) A61B 5/7203 (20130101) A61B 5/7267 (20130101) A61B 5/14546 (20130101) A61B 2576/02 (20130101) Image Data Processing or Generation, in General G06T 7/0014 (20130101) Original (OR) Class G06T 2207/10016 (20130101) G06T 2207/10152 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30101 (20130101) Image or Video Recognition or Understanding G06V 30/194 (20220101) G06V 40/10 (20220101) G06V 40/14 (20220101) Technologies for Adaptation to Climate Change Y02A 90/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220254191 | MARTINEZ |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aleix MARTINEZ (Columbus, Ohio) |
| ABSTRACT | The innovation disclosed and claimed herein, in aspects thereof, comprises systems and methods of identifying AUs and emotion categories in images. The systems and methods utilized a set of images that include facial images of people. The systems and methods analyze the facial images to determine AUs and facial color due to facial blood flow variations that are indicative of an emotion category. In aspects, the analysis can include Gabor transforms to determine the AUs, AU intensities and emotion categories. In other aspects, the systems and method can include color variance analysis to determine the AUs, AU intensities and emotion categories. In further aspects, the analysis can include convolutional neural networks that are trained to determine the AUs, emotion categories and their intensities. |
| FILED | Tuesday, April 05, 2022 |
| APPL NO | 17/713481 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Image or Video Recognition or Understanding G06V 40/169 (20220101) G06V 40/171 (20220101) G06V 40/175 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20220249486 | Du et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yang Du (Gaithersburg, Maryland); Nhu Nguyen (Rockville, Maryland); Kristbjorn Gudmundsson (Silver Spring, Maryland) |
| ABSTRACT | The present disclosure relates to compounds that inhibit SETBP1 or XP01 activities. Also disclosed are methods of using such compounds to increase the expression of embryonic and fetal hemoglobin molecules, and to treat sickle cell disease and β-thalassemia. The present invention relates to unexpected findings that transcription factor SETBP1 regulates embryonic and fetal hemoglobin repression, and inhibition of SETBP1 can induce the expression of embryonic and fetal hemoglobins. |
| FILED | Thursday, June 04, 2020 |
| APPL NO | 17/616158 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/517 (20130101) Original (OR) Class A61K 31/4745 (20130101) A61K 31/7088 (20130101) A61K 31/7105 (20130101) A61K 38/465 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249604 | Zuo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | St. Jude Children's Research Hospital (Memphis, Tennessee) |
| ASSIGNEE(S) | St. Jude Children's Research Hospital (Memphis, Tennessee) |
| INVENTOR(S) | Jian Zuo (Omaha, Nebraska); Fei Zheng (Memphis, Tennessee); Tetsuji Yamashita (Memphis, Tennessee); Wanda Layman (Germantown, Tennessee) |
| ABSTRACT | Methods and compositions using a nucleic acid molecule encoding an atonal-associated factor in combination with a co-transcription factor and/or inhibitor of a gene silencing complex to change the sensory perception of an animal are described. |
| FILED | Wednesday, March 16, 2022 |
| APPL NO | 17/696808 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0275 (20130101) A01K 2217/052 (20130101) A01K 2217/206 (20130101) A01K 2227/105 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0046 (20130101) A61K 31/7105 (20130101) A61K 38/1709 (20130101) Original (OR) Class A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249732 | Bowlin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Virginia Commonwealth University (Richmond, Virginia); The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gary Bowlin (Mechanicsville, Virginia); David Simpson (Mechanicsville, Virginia); James Bowman (Richmond, Virginia); Stephen Rothwell (Richmond, Virginia) |
| ABSTRACT | The invention generally relates to dextran fibers which are preferably electrospun and devices formed from such fibers. In particular, such devices may include substances of interest (such as therapeutic substances) associated with the electrospun fibers. Upon exposure to a liquid the electrospun fibers dissolve immediately and the substances of interest are released into the liquid. Exemplary devices include bandages formed from electrospun dextran fibers and associated agents that promote hemostasis, such as thrombin and fibrinogen. |
| FILED | Wednesday, December 01, 2021 |
| APPL NO | 17/539273 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 15/28 (20130101) Original (OR) Class A61L 15/32 (20130101) A61L 15/38 (20130101) A61L 15/44 (20130101) A61L 2300/252 (20130101) A61L 2300/254 (20130101) A61L 2300/418 (20130101) A61L 2400/04 (20130101) Technical Subjects Covered by Former US Classification Y10T 156/10 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249771 | Nerkar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cepheid (Sunnyvale, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rajesh Nerkar (Sunnyvale, California); Amrita Chimni (Sunnyvale, California); Yajing Liu (Sunnyvale, California); Janaki-rama Vegiraju (Sunnyvale, California); Ricahard J. Casler (Sunnyvale, California) |
| ABSTRACT | Methods and systems for estimating force and motor torque in a mechatronic system are provided herein. Such methods and system are suited for improved control of small-scale mechatronic system, particularly a syringe, valve, and cartridge loader or door opening/closing mechanism of a diagnostic assay system. The methods can compensate for friction and account for various second-order effects, thereby allowing for more accurate pressure estimation, thereby allowing improved syringe operation. The methods can further allow for improved estimation of force or motor torque to allow for improved control of an actuatable valve interfacing the sample cartridge and cartridge loader or door opening/closing system. Methods of calibrating such systems are also provided. |
| FILED | Thursday, January 13, 2022 |
| APPL NO | 17/575009 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/172 (20130101) Original (OR) Class A61M 5/16831 (20130101) A61M 2205/50 (20130101) A61M 2205/332 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220250032 | McGill et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | R. Andrew McGill (Lorton, Virginia); Courtney A. Roberts (Washington, District of Columbia) |
| ABSTRACT | The invention relates to strong hydrogen-bond acidic sorbents. The sorbents may be provided in a form that limits or eliminates intramolecular bonding of the hydrogen-bond acidic site between neighboring sorbent molecules, for example, by providing steric groups adjacent to the hydrogen-bond acidic site. The hydrogen bond site may be a phenolic structure based on a bisphenol architecture. The sorbents of the invention may be used in methods for trapping or detecting hazardous chemicals or explosives. |
| FILED | Thursday, April 21, 2022 |
| APPL NO | 17/725811 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/22 (20130101) Original (OR) Class B01J 20/282 (20130101) B01J 20/3425 (20130101) B01J 20/3483 (20130101) B01J 20/28023 (20130101) B01J 2220/54 (20130101) Acyclic or Carbocyclic Compounds C07C 39/367 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 14/06 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 59/00 (20130101) C08G 64/00 (20130101) C08G 64/10 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/482 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220250055 | Goyal et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Girija Goyal (Cambridge, Massachusetts); Donald E. Ingber (Boston, Massachusetts) |
| ABSTRACT | An organ-on-a-chip microfluidic device is disclosed that mimics a human lymph node and/or human lymphoid tissue. The device can include cells from human blood and lymphatic tissue, include an extracellular matrix for the development of immune system components, and provide for the perfusion of fluids and solids resembling blood and lymphatic fluid within micrometer sized channels. |
| FILED | Wednesday, April 27, 2022 |
| APPL NO | 17/730615 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 35/28 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/00 (20180101) A61P 35/00 (20180101) A61P 37/04 (20180101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/5027 (20130101) Original (OR) Class B01L 2300/0861 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) C12M 23/16 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0018 (20130101) C12N 5/069 (20130101) C12N 5/0635 (20130101) C12N 5/0636 (20130101) C12N 5/0645 (20130101) C12N 5/0651 (20130101) C12N 5/0693 (20130101) C12N 2531/00 (20130101) C12N 2533/52 (20130101) C12N 2533/54 (20130101) C12N 2533/90 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5011 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220250732 | Walter |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BOEING COMPANY (Chicago, Illinois) |
| ASSIGNEE(S) | THE BOEING COMPANY (CHICAGO, Illinois) |
| INVENTOR(S) | Matthew W. Walter (Troy, Missouri) |
| ABSTRACT | A canopy for an aircraft includes a pivot assembly including a first hinge and a second hinge opposite from the first hinge. The first hinge includes a first pivot slot having a first length. The first pivot slot is configured to retain a first aft pin of a fuselage of the aircraft. The second hinge includes a second pivot slot having a second length. The second pivot slot is configured to retain a second aft pin of the fuselage of the aircraft. The first length differs from the second length. |
| FILED | Wednesday, September 08, 2021 |
| APPL NO | 17/468973 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 1/32 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220250733 | Walter |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BOEING COMPANY (CHICAGO, Illinois) |
| ASSIGNEE(S) | THE BOEING COMPANY (CHICAGO, Illinois) |
| INVENTOR(S) | Matthew W. Walter (Troy, Missouri) |
| ABSTRACT | A system for initiating a canopy release signal for a canopy of an aircraft includes a first striker secured to the canopy, and a first initiator assembly secured to a fuselage of the aircraft. The first initiator assembly has a protrusion. The first striker is configured to be rotated against the protrusion of the first initiator assembly. The canopy release signal is output in response to the first striker rotating against the protrusion of the first initiator assembly. |
| FILED | Friday, November 19, 2021 |
| APPL NO | 17/530607 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 1/32 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220250913 | Tse et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen D. Tse (Warren, New Jersey); Hua Hong (Weehawken, New Jersey); Bernard H. Kear (Whitehouse Station, New Jersey) |
| ABSTRACT | Methods for the production of carbon-based and other nanostructures are provided. |
| FILED | Friday, December 17, 2021 |
| APPL NO | 17/554293 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/184 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220250935 | AIZENBERG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joanna AIZENBERG (Cambridge, Massachusetts); Tanya SHIRMAN (Arlington, Massachusetts); Katherine Reece PHILLIPS (Cambridge, Massachusetts); Elijah SHIRMAN (Arlington, Massachusetts); Theresa KAY (South Stoney Creek, Canada) |
| ABSTRACT | A co-assembly method for synthesizing inverse photonic structures is described. The method includes combining an onium compound with a sol-gel precursor to form metal oxide (MO) nanocrystals, where each MO nanocrystal has crystalline and amorphous content. The MO nanocrystals are combined with templating particles to form a suspension. A solvent is evaporated from the suspension to form an intermediate or compound product, which then undergoes calcination to produce an inverse structure. |
| FILED | Monday, December 06, 2021 |
| APPL NO | 17/543494 |
| CURRENT CPC | Separation B01D 39/2027 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/06 (20130101) B01J 20/08 (20130101) B01J 20/3085 (20130101) B01J 20/28007 (20130101) B01J 21/04 (20130101) B01J 21/063 (20130101) B01J 21/066 (20130101) B01J 35/004 (20130101) B01J 35/0013 (20130101) B01J 37/04 (20130101) B01J 37/0215 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Compounds of the Metals Beryllium, Magnesium, Aluminium, Calcium, Strontium, Barium, Radium, Thorium, or of the Rare-earth Metals C01F 7/02 (20130101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 23/047 (20130101) C01G 23/053 (20130101) C01G 25/02 (20130101) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2004/03 (20130101) C01P 2004/04 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 17/007 (20130101) C09D 17/008 (20130101) Starting of Combustion Engines; Starting Aids for Such Engines, Not Otherwise Provided for F02N 11/08 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/48 (20130101) H01M 4/9016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251160 | IRVINE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Darrell J. IRVINE (Arlington, Massachusetts); Yiran ZHENG (Cambridge, Massachusetts); Yuan ZHANG (Dorchester, Massachusetts); Brandon KWONG (Toronto, Canada) |
| ABSTRACT | The invention provides compositions and methods for, inter alia, augmenting cell-based therapies in vivo by repeatedly stimulating target cells of interest over a period of time. |
| FILED | Tuesday, November 09, 2021 |
| APPL NO | 17/522663 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/1271 (20130101) A61K 39/3955 (20130101) A61K 47/642 (20170801) A61K 47/6849 (20170801) A61K 47/6911 (20170801) A61K 47/6913 (20170801) A61K 2035/122 (20130101) Peptides C07K 14/55 (20130101) Original (OR) Class C07K 16/2803 (20130101) C07K 16/2878 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251240 | Marks et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James D. Marks (Kensington, California); Maria Consuelo Garcia Rodriguez (San Francisco, California); Shude Yan (San Bruno, California) |
| ABSTRACT | The present disclosure provides antibodies that specifically bind to botulinum neurotoxins (e.g., BoNT/A, BoNT/B, BoNT/C, BoNT/D, BoNT/E, BoNT/F, BoNT/G, etc.) and the epitopes bound by those antibodies. The antibodies and derivatives thereof that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism. |
| FILED | Thursday, February 03, 2022 |
| APPL NO | 17/592012 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Peptides C07K 16/40 (20130101) Original (OR) Class C07K 16/1282 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/573 (20130101) G01N 33/56911 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251322 | Matis et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Bernard R. Matis (Alexandria, Virginia); Nicholas T. Gangemi (Washington, District of Columbia); Jeffrey W. Baldwin (Fairfax, Virginia); Steven W. Liskey (Odenton, Maryland); Aaron D. Edmunds (Alexandria, Virginia); William B. Wilson (Pasadena, Maryland); Douglas M. Photiadis (Alexandria, Virginia) |
| ABSTRACT | An article having: an elastomeric jacket; a gel within the jacket; and a plurality of gas-filled, polymerically-encapsulated microbubbles suspended in the gel. The microbubbles have a Gaussian particle size distribution. The largest microbubble has a diameter at least 10 times the diameter of the smallest microbubble. The article may exhibit Anderson localization at at least one frequency of sound waves impacting the article. |
| FILED | Tuesday, January 25, 2022 |
| APPL NO | 17/583697 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/075 (20130101) C08J 9/236 (20130101) Original (OR) Class C08J 2205/02 (20130101) C08J 2300/26 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/036 (20130101) G01N 2291/02433 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251544 | JOHNSTON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen Albert JOHNSTON (Tempe, Arizona); Luhui SHEN (Tempe, Arizona) |
| ABSTRACT | Provided herein, are methods of identifying neoantigens for treating and preventing cancer. Also disclosed are methods and compositions for administering identified neoantigens for the treatment and prevention of cancer. |
| FILED | Monday, March 28, 2022 |
| APPL NO | 17/706469 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1062 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57484 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251602 | Gao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | University of Massachusetts (Boston, Massachusetts) |
| INVENTOR(S) | Guangping Gao (Westborough, Massachusetts); Phillip Tai (Worcester, Massachusetts); Elisabet C. Mandon (Shrewsbury, Massachusetts); Jianzhong Ai (Worcester, Massachusetts) |
| ABSTRACT | In some aspects, the disclosure provides recombinant AAV and nucleic acid constructs having novel inverted terminal repeats (ITRs), cap, and/or rep genes. In some aspects, the disclosure relates to gene transfer methods using rAAVs described herein. |
| FILED | Tuesday, February 01, 2022 |
| APPL NO | 17/590337 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 2750/14143 (20130101) C12N 2750/14171 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251647 | Tsalik et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duke University (Durham, North Carolina); United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ephraim L. Tsalik (Cary, North Carolina); Geoffrey S. Ginsburg (Durham, North Carolina); Christopher W. Woods (Durham, North Carolina); Ricardo Henao Giraldo (Durham, North Carolina); Rachel A. Myers (Raleigh, North Carolina) |
| ABSTRACT | The present disclosure provides methods for determining whether a subject has sepsis, or is at risk of developing sepsis, and methods of treating the subject based on the determination. Also provided are methods for determining an increased risk of mortality in a subject with sepsis or suspected of having sepsis, and methods of treating the subject based on the determination. Systems useful for the same are also provided. |
| FILED | Friday, February 18, 2022 |
| APPL NO | 17/651579 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6876 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220252089 | Howard et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | QUALITY MANUFACTURING INC. (Winchester, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Harold Howard (Winchester, Kentucky); George Evan Mattingly (Winchester, Kentucky); Jeffrey John Sweda (Lexington, Kentucky); Jeffrey A. Rose (Lexington, Kentucky) |
| ABSTRACT | Devices and systems for producing rotational actuation are described. Hydraulic and pneumatic actuators can produce and control rotational motion. A rotary joint may be configured to allow parallel coupling of multiple actuators, and thus increase the range of rotation of the actuators when considered collectively. The actuators may include pistons and piston rods having torus shapes. Methods of manufacturing rotary joints are also described. |
| FILED | Wednesday, January 19, 2022 |
| APPL NO | 17/648359 |
| CURRENT CPC | Systems Acting by Means of Fluids in General; Fluid-pressure Actuators, e.g Servomotors; Details of Fluid-pressure Systems, Not Otherwise Provided for F15B 15/125 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220252180 | Mendez |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edgar G Mendez (California City, California) |
| ABSTRACT | Valves, the components used to create valves and, more particularly, to piston-activated cartridge valves are disclosed. The valves include cartridge valve assemblies having a housing and a slidable member, the major part of which is located within the internal space of the housing. One end of the slidable member extends outward beyond the second end of the cartridge housing, and can be contacted by an actuator piston to open the valve. The interior surface of the cartridge housing and the sides of the slidable member are configured so that when the slidable member is in the open position, at least one fluid flow path is provided between the first and second openings of the cartridge housing so that fluid can flow either: (a) from the first opening to the second opening; or (b) from the second opening to the first opening. A system comprising a plurality of insertable devices that are used to create various valve configurations is also provided herein, as are various fluid circuits that can be created using the insertable devices described herein. |
| FILED | Wednesday, January 12, 2022 |
| APPL NO | 17/573675 |
| CURRENT CPC | Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 11/14 (20130101) F16K 31/52416 (20130101) Original (OR) Class Pipes; Joints or Fittings for Pipes; Supports for Pipes, Cables or Protective Tubing; Means for Thermal Insulation in General F16L 41/021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220252309 | Yu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| INVENTOR(S) | Nanfang Yu (Fort Lee, New Jersey); Jyotirmoy Mandal (New York, New York); Adam Overvig (New York, New York); Norman Nan Shi (San Jose, California); Meng Tian (Fort Lee, New Jersey) |
| ABSTRACT | Systems and methods for radiative cooling and heating are provided. For example, systems for radiative cooling can include a top layer including one or more polymers, where the top layer has high emissivity in at least a portion of the thermal spectrum and an electromagnetic extinction coefficient of approximately zero, absorptivity of approximately zero, and high transmittance in at least a portion of the solar spectrum, and further include a reflective layer including one or more metals, where the reflective layer has high reflectivity in at least a portion of the solar spectrum. |
| FILED | Monday, March 21, 2022 |
| APPL NO | 17/699789 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 27/18 (20130101) B32B 27/283 (20130101) B32B 33/00 (20130101) Solar Heat Collectors; Solar Heat Systems F24S 10/40 (20180501) F24S 70/30 (20180501) F24S 70/60 (20180501) F24S 70/225 (20180501) Refrigeration Machines, Plants or Systems; Combined Heating and Refrigeration Systems; Heat-pump Systems F25B 23/003 (20130101) Original (OR) Class Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 2245/06 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/44 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220252452 | REDMOND et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Shawn REDMOND (Concord, Massachusetts); Patrick Hassett (Nashua, New Hampshire); Salvatore Di Cecca (Cambridge, Massachusetts) |
| ABSTRACT | A two-layer hybrid solid wedged etalon was fabricated and combined with a traditional imager to make a compact computational spectrometer. The hybrid wedge was made of Nb2O5 and Infrasil 302 and was designed to operate from 0.4-2.4 μm. Initial demonstrations used a CMOS imager and operated from 0.4-0.9 μm with spectral resolutions<30 cm−1 from single snapshots. The computational spectrometer operates similarly to a spatial Fourier Transform infrared (FTIR) spectrometer with spectral reconstruction using a non-negative least squares fitting algorithm based on analytically computed wavelength response vectors determined from extracted physical thicknesses across the entire two-dimensional wedge. This computational technique resulted in performance and spectral resolutions exceeding those that could be achieved from Fourier techniques. With an additional imaging lenses and translational scanning, the system can be converted into a hyperspectral imager. |
| FILED | Thursday, December 09, 2021 |
| APPL NO | 17/546631 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/0256 (20130101) Original (OR) Class G01J 3/2823 (20130101) G01J 2003/4538 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220252792 | Puckett et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Honeywell International Inc. (Charlotte, North Carolina) |
| ASSIGNEE(S) | Honeywell International Inc. (Charlotte, North Carolina) |
| INVENTOR(S) | Matthew Wade Puckett (Phoenix, Arizona); Chad Fertig (Bloomington, Minnesota); Neil A. Krueger (Saint Paul, Minnesota); Karl D. Nelson (Plymouth, Minnesota); Chad Hoyt (Roseville, Minnesota) |
| ABSTRACT | A multilayer waveguide coupler comprising a first grating and a second grating is provided. Each first copropagating waveguide of the first grating has a first periodically modulated width. Each second copropagating waveguide of the second grating has a second periodically modulated width. The second grating is positioned so that a phase offset is present between the first periodically modulated width of the first copropagating waveguides and the second periodically modulated width of the second copropagating waveguides. The grating spaced distance and phase offset are selected so that light diffracted out of the first copropagating waveguides and the second copropagating waveguides in the first direction interferes constructively to form the first light beam and light diffracted out of the first copropagating waveguides and the second copropagating waveguides in the second direction interferes destructively. |
| FILED | Tuesday, May 04, 2021 |
| APPL NO | 17/307757 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/34 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220252958 | Fejer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin M. Fejer (Emerald Hills, California); Carsten Langrock (Santa Clara, California); Marc P. Jankowski (Palo Alto, California) |
| ABSTRACT | Improved efficiency for nonlinear optical interactions is provided by using strongly confining waveguides for simultaneous imposition of dispersion design constraints at two or more dispersion orders. Quasi-phase-matching allows for phase-matching to be accomplished independently of the waveguide design, which helps provide sufficient design freedom for the dispersion design. |
| FILED | Friday, March 12, 2021 |
| APPL NO | 17/200422 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/392 (20210101) G02F 1/395 (20130101) G02F 1/3528 (20210101) G02F 1/3548 (20210101) Original (OR) Class G02F 1/3775 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220253079 | Lee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cepheid (Sunnyvale, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marissa Lee (Sunnyvale, California); Jessica Koay (Sunnyvale, California); Charles Rohrs (Sunnyvale, California); Earl Solis (Sunnyvale, California); Matthew Piccini (Sunnyvale, California); Richard J. Casler, JR. (Sunnyvale, California) |
| ABSTRACT | Thermal control devices and methods to provide improved control, speed and efficiency in temperature cycling are provided herein. Such thermal control device and methods can include one or more active elements, such a thermoelectric cooler device, that is controlled by an algorithm that regulates a temperature distribution of an adjacent reaction-vessel according to a temperature distribution command trajectory and estimated reaction-vessel temperature distribution. Some embodiments include two active elements that are bilaterally applied to opposing sides of the reaction-vessel. In some embodiments, the estimated reaction-vessel temperature is determined based on a state of power electronics of the element and a temperature output of one or more sensors of a portion of the element and/or an ambient environment of the reaction-vessel. Methods of calibration of such systems utilizing a thermal calibrator as a proxy for the reaction-vessel are also provided herein. |
| FILED | Thursday, January 13, 2022 |
| APPL NO | 17/574951 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 1/025 (20130101) B01L 7/52 (20130101) B01L 2300/0663 (20130101) B01L 2300/0681 (20130101) B01L 2300/1822 (20130101) B01L 2300/1894 (20130101) Refrigeration Machines, Plants or Systems; Combined Heating and Refrigeration Systems; Heat-pump Systems F25B 21/02 (20130101) Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 1/026 (20130101) G01K 13/024 (20210101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/42 (20130101) G01N 1/44 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 23/1931 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220253206 | Bergsrud et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Corey Alexis Marvin Bergsrud (Bloomington, Indiana); Alex John Zellner (Indianapolis, Indiana); Kristina Rose Preucil (Burlington, New Jersey) |
| ABSTRACT | Systems and related methods are provided for improving cognitive function of a wireless power system designer and simulate various aspects of a wireless power system as an aid in making design selections in a tradeoff environment. Various embodiment enable such improved cognitive function by providing machine instructions that generate various graphical user interfaces which enable the wireless power system designer to visualize, compare, select, and change a variety of independent and dependent variables pertaining to a plurality of potential wireless power systems, a plurality of potential diodes, and a plurality of potential coplanar striplines for use in a plurality of operational environments as desired by the wireless power system designer. Aspects of various embodiments display design constraint warnings thereby providing visual display of design space solutions that do not violate various design constraints. |
| FILED | Thursday, August 12, 2021 |
| APPL NO | 17/400546 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/0482 (20130101) G06F 3/04847 (20130101) Original (OR) Class G06F 30/12 (20200101) G06F 30/20 (20200101) Image Data Processing or Generation, in General G06T 11/206 (20130101) G06T 2200/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220253290 | NGUYEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Aerospace Corporation (El Segundo, California) |
| ASSIGNEE(S) | The Aerospace Corporation (, None) |
| INVENTOR(S) | Tien M. NGUYEN (Yorba Linda, California); Andrew T. GUILLEN (Redondo Beach, California); Anh X. DANG (Redondo Beach, California); Thomas O. FREEZE (El Segundo, California); Jake T. SINGH (Los Angeles, California); Alexander K. CHANG (Long Beach, California); Faisal M. ZAHIDI (Chino Hills, California); Hung H. NGUYEN (Chantilly, Virginia); Jonathan H. LEE (Los Angeles, California); Vahe Y. AVEDISSIAN (Rolling Hills, California) |
| ABSTRACT | A digital engineering (DE) platform configured to support space system development and acquisition. The DE platform includes a modular reference architecture models module configured to capture key modular system elements of interest using model-based system engineering (MBSE) and digital object oriented requirements system (DOORS) tools. The DE platform also includes a connectivity matrix module defining interface or specifications between one or more modular system elements. The DE platform is also configured to digitize the interface using a behavior model. The behavior model capturing required activity and/or sequence for a particular use case. |
| FILED | Thursday, February 11, 2021 |
| APPL NO | 17/173465 |
| CURRENT CPC | Electric Digital Data Processing G06F 8/35 (20130101) Original (OR) Class G06F 9/541 (20130101) G06F 9/4881 (20130101) G06F 9/44505 (20130101) G06F 16/289 (20190101) G06F 16/2282 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220253658 | Fink et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Advanced Functional Fabrics of America (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yoel Fink (Brookline, Massachusetts); Nicholas Dimitruk (Belmont, Massachusetts); Federico Bescotti (Boston, Massachusetts); Catherine Chapman (Spartanburg, South Carolina) |
| ABSTRACT | Exemplary embodiments use a single, physical embodiment that compiles independent machine-readable codes together with little to no space in between codes. This physical embodiment is in two primary forms—adhesive tape or fabric strips with hook and loop backing. A code reader device, with software compatible with the machine-readable codes, can rapidly or simultaneously aggregate independent codes together on the physical embodiment in order to assign them to one or more digital addresses. |
| FILED | Friday, August 13, 2021 |
| APPL NO | 17/401939 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 19/06037 (20130101) G06K 19/06093 (20130101) Original (OR) Class Displaying; Advertising; Signs; Labels or Name-plates; Seals G09F 3/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220254486 | Radhakrishnan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents of the University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hari Radhakrishnan (Houston, Texas); John B. Holcomb (Bellaire, Texas); Charles E. Wade (Houston, Texas); Bryan Cotton (Katy, Texas); Rondel Albarado (Houston, Texas); Drew Kraus (Friendswood, Texas); Joel Watts (Houston, Texas); Binod Shrestha (Houston, Texas) |
| ABSTRACT | Embodiments disclosed herein provide a system, method, and computer program product for providing a patient dashboard system in a patient care setting. The patient dashboard system collects and stores patient data from a variety of sources. The collected patient data is filtered, analyzed, and displayed. The patient dashboard system displays patient data that is relevant to the treatment of the patient, including recommended medical actions and pertinent positives and pertinent negatives. |
| FILED | Friday, February 25, 2022 |
| APPL NO | 17/681376 |
| CURRENT CPC | Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) G16H 15/00 (20180101) G16H 40/63 (20180101) Original (OR) Class G16H 40/67 (20180101) G16H 50/20 (20180101) G16H 70/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220254584 | Kirby et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | Raytheon Company (, None) |
| INVENTOR(S) | Bryce Kirby (Berlin, Massachusetts); Craig K. Johnson, JR. (Northborough, Massachusetts); Andrew A. McMahon (Milford, New Hampshire) |
| ABSTRACT | A rotational over travel protection device for preventing over rotation of at least one of a cable, or a component operable with the rotational over travel protection device is provided. The device includes a housing, a rotatable shaft connected to the housing that can rotate relative to the house, and a triggering device supported in the housing and rotatable with the rotatable shaft. The device also includes a first and second rotational limit switch disposed in the housing. The switches are operable to be activated by the triggering device to arrest rotation of the rotatable shaft upon relative rotation of the rotatable shaft and the housing either a first or second rotation direction, respectively, at least 180 degrees from a zero position. |
| FILED | Thursday, February 11, 2021 |
| APPL NO | 17/174298 |
| CURRENT CPC | Capstans; Winches; Tackles, e.g Pulley Blocks; Hoists B66D 1/56 (20130101) Electric Switches; Relays; Selectors; Emergency Protective Devices H01H 21/285 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220254639 | Anderson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Travis J. Anderson (Alexandria, Virginia); James C. Gallagher (Alexandria, Virginia); Marko J. Tadjer (Vienna, Virginia); Alan G. Jacobs (Arlington, Virginia); Boris N. Feigelson (Springfield, Virginia) |
| ABSTRACT | A method for activating implanted dopants and repairing damage to dopant-implanted GaN to form n-type or p-type GaN. A GaN substrate is implanted with n- or p-type ions and is subjected to a high-temperature anneal to activate the implanted dopants and to produce planar n- or p-type doped areas within the GaN having an activated dopant concentration of about 1018-1022 cm−3. An initial annealing at a temperature at which the GaN is stable at a predetermined process temperature for a predetermined time can be conducted before the high-temperature anneal. A thermally stable cap can be applied to the GaN substrate to suppress nitrogen evolution from the GaN surface during the high-temperature annealing step. The high-temperature annealing can be conducted under N2 pressure to increase the stability of the GaN. The annealing can be conducted using laser annealing or rapid thermal annealing (RTA). |
| FILED | Wednesday, January 26, 2022 |
| APPL NO | 17/584477 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/266 (20130101) H01L 21/3245 (20130101) H01L 21/26546 (20130101) Original (OR) Class H01L 21/28575 (20130101) H01L 29/36 (20130101) H01L 29/207 (20130101) H01L 29/452 (20130101) H01L 29/2003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220255137 | Stoddart et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois); King Abdulaziz City for Science and Technology (KACST} (Riyadh, Saudi Arabia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Fraser Stoddart (Evanston, Illinois); Mirkin A. Chad (Wilmetie, Illinois); Woo Nam Kwan (Evanston, Illinois); Park S. Sarah (Evanston, Illinois) |
| ABSTRACT | Disclosed herein are batteries comprising a M3(C6(C6H2X2)3)2 active material, wherein M is a late transition metal and X is selected from O, S, or NH, and an aqueous electrolyte comprising a multivalent cationic charge carrier. Also disclosed are methods of making the same. |
| FILED | Friday, July 10, 2020 |
| APPL NO | 17/597507 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/42 (20130101) H01M 4/0404 (20130101) H01M 4/5815 (20130101) H01M 4/5825 (20130101) H01M 10/38 (20130101) Original (OR) Class H01M 2004/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220255241 | Taylor et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian L. Taylor (Anna, Texas); David M. Dyer (Prosper, Texas); Steven Sprinkle (Van Alstyne, Texas); Paul E. Schlittler (Mc Kinney, Texas) |
| ABSTRACT | A radio frequency (RF) circuit connection assembly comprises a RF circuit board and a RF connector. The RF circuit board has a first side and a second side opposite the first side. A RF circuit is located on the first side and an aperture extends through the RF circuit board from the first side to the second side. The RF connector comprises a barrel having a socket configured to receive a RF bullet, a flange having a mounting surface, and a RF connector pin extending laterally from the barrel. The barrel of the RF connector extends through the aperture of the RF circuit board such that the mounting surface of the flange is seated against the first side of the RF circuit board, and the RF connector pin is electrically coupled to the RF circuit on the first side of the RF circuit board. |
| FILED | Wednesday, November 10, 2021 |
| APPL NO | 17/523406 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 9/16 (20130101) H01Q 21/28 (20130101) H01Q 23/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220255553 | Zhao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Digital Analog Integration, Inc. (Auburn, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Haoyi Zhao (Auburn, Alabama); Fa Dai (Auburn, Alabama); John David Irwin (Auburn, Alabama) |
| ABSTRACT | An analog-to-digital converter includes a first converter stage, a second converter stage coupled to the first converter stage to quantize a residue signal of the first converter stage, and an inter-stage converter disposed between the first and second converter stages. The inter-stage converter is configured to convert between a first domain and a second domain. The inter-stage converter is configured to process the residue signal of the first converter stage such that a range of the residue signal matches a full scale of the second converter stage. |
| FILED | Thursday, October 28, 2021 |
| APPL NO | 17/513476 |
| CURRENT CPC | Coding; Decoding; Code Conversion in General H03M 1/002 (20130101) Original (OR) Class H03M 1/1009 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220255632 | Schibli |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas Richard Schibli (Boulder, Colorado) |
| ABSTRACT | A photonic-based microwave generator includes a mode-locked laser that generates an optical pulse train, a feedback photodiode that samples the optical pulse train, and a servo amplifier that processes the photodiode output into a servo signal. The servo signal controls the mode-locked laser to suppress relative intensity noise on the optical pulse train. The microwave generator may also include a microwave photodiode for converting the optical pulse train into a microwave signal. The microwave generator may also include a second servo amplifier that processes a low-frequency output of the microwave photodiode into a second servo signal that drives an optical modulator that modulates the optical pulse train. The microwave photodiode, optical modulator, and servo amplifier form a feedback loop that suppresses amplitude noise on the microwave signal. By reducing amplitude noise and relative intensity noise, phase noise caused by amplitude-to-phase noise conversion is minimized. |
| FILED | Tuesday, February 23, 2021 |
| APPL NO | 17/182527 |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/091 (20130101) H01S 3/1305 (20130101) Transmission H04B 10/806 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220255652 | Shinder |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOEING COMPANY (CHICAGO, Illinois) |
| ASSIGNEE(S) | THE BOEING COMPANY (CHICAGO, Illinois) |
| INVENTOR(S) | Sam Shinder (Gaithersburg, Maryland) |
| ABSTRACT | A serializer includes a recursive tree of serializer unit cells. Each serializer unit cell includes a multiplexer and a plurality of flip-flops coupled to the multiplexer. Each serializer unit cell contains a state machine defining operation of the corresponding serializer unit cell. The recursive tree is organized with upper level serializer unit cells disposed more closely to a serializer output than are lower level serializer unit cells. The recursive tree is configured such that each serializer unit cell that is adjacent to and in an upper position relative to a corresponding lower level serializer unit cell directs the corresponding lower level serializer unit cell to output data, and the corresponding lower level serializer unit cell communicates to the corresponding serializer unit cell when the corresponding lower level serializer unit cell is done outputting data. |
| FILED | Friday, February 05, 2021 |
| APPL NO | 17/169259 |
| CURRENT CPC | Pulse Technique H03K 3/037 (20130101) Multiplex Communication H04J 3/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220255775 | D'Oro et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Salvatore D'Oro (Allston, Massachusetts); Tommaso Melodia (Newton, Massachusetts); Francesco Restuccia (Boston, Massachusetts) |
| ABSTRACT | A machine learning (ML) agent operates at a transmitter to optimize signals transmitted across a communications channel. A physical signal modifier modifies a physical layer signal prior to transmission as a function of a set of signal modification parameters to produce a modified physical layer signal. The ML agent parses a feedback signal from a receiver across the communications channel, and determines a present tuning status as a function of the signal modification parameters and the feedback signal. The ML agent generates subsequent signal modification parameters based on the present tuning status and a set of stored tuning statuses, thereby updating the physical signal modifier to generate a subsequent modified physical layer signal to be transmitted across the communications channel. |
| FILED | Friday, February 11, 2022 |
| APPL NO | 17/650686 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 1/0073 (20130101) H04L 5/0055 (20130101) H04L 25/0254 (20130101) Original (OR) Class H04L 25/03006 (20130101) H04L 2025/03464 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20220250010 | LEE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Tae H. LEE (Naperville, Illinois); Uthamalingam BALACHANDRAN (Willowbrook, Illinois) |
| ABSTRACT | Ceramic proton-conducting oxide membranes are described herein, which are useful for separating steam from organic chemicals under process conditions. The membranes have a layered structure, with a dense film of the perovskite over a porous composite substrate comprising the perovskite material and a metallic material (e.g., Ni, Cu, or Pt). The perovskite comprises an ABO3-type structure, where “A” is Ba and “B” is a specified combination of Ce, Zr, and Y. The perovskite ceramic materials described herein have an empirical formula of Ba(CexZr1-x-nYn)O3-δ, wherein 0<x<0.8 (e.g., 0.1≤x≤0.7 or 0.2≤x≤0.5); and 0.05≤n≤0.2; and δ=n/2. In some embodiments n is about 0.2. In some other embodiments 0.6≤x≤0.8; and n is about 0.2, such as Ba(Ce0.7Zr0.1Y0.2)O3-δ, also referred to herein as BCZY712. |
| FILED | Friday, February 05, 2021 |
| APPL NO | 17/168646 |
| CURRENT CPC | Separation B01D 53/228 (20130101) B01D 63/063 (20130101) B01D 69/02 (20130101) B01D 69/12 (20130101) B01D 71/024 (20130101) Original (OR) Class B01D 2053/223 (20130101) B01D 2325/02 (20130101) B01D 2325/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220250096 | HOSSAIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mohammad Arif HOSSAIN (Lake Jackson, Texas); Jeffrey P. BONS (Dublin, Ohio); James W. GREGORY (Columbus, Ohio); Ali AMERI (Solon, Ohio) |
| ABSTRACT | Various implementations include, an out-of-plane feedback-type fluidic oscillator. including a first portion, a second portion, a middle portion coupled between the first portion and the middle portion, and an axis of rotation. The middle portion includes a first side, a second side opposite and spaced apart from the first side, and a middle plane, an interaction chamber, a fluid supply inlet, an outlet nozzle, a first feedback a channel, and a second feedback channel. The first side is coupled to the first portion, and the second side is coupled to the second portion. The first side, the second side, and the middle plane extend circumferentially around the axis of rotation. The middle plane is disposed equally distanced from the first side and the second side. The fluid stream oscillates as it flows through the interaction chamber such that the fluid stream oscillates as the fluid stream exits the outlet nozzle. |
| FILED | Thursday, May 28, 2020 |
| APPL NO | 17/614135 |
| CURRENT CPC | Spraying Apparatus; Atomising Apparatus; Nozzles B05B 1/08 (20130101) Original (OR) Class Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 25/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220250929 | Islam et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Jackson State University (Jackson, Mississippi) |
| ASSIGNEE(S) | Jackson State University (Jackson, Mississippi) |
| INVENTOR(S) | Muhammad Saiful Islam (Madison, Mississippi); Ahmet Celika (Nizip, Turkey) |
| ABSTRACT | A hybrid functionalized lamellar comprises a layered double hydroxide and [Sn2S6]4− anions intercalated with the gallery of the layered double hydroxide to form a [Sn2S6]4− intercalated layered double hydroxide. |
| FILED | Thursday, February 10, 2022 |
| APPL NO | 17/669201 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/041 (20130101) B01J 20/3071 (20130101) B01J 20/28033 (20130101) Compounds of the Metals Beryllium, Magnesium, Aluminium, Calcium, Strontium, Barium, Radium, Thorium, or of the Rare-earth Metals C01F 7/784 (20220101) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/22 (20130101) C01P 2002/72 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220250935 | AIZENBERG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joanna AIZENBERG (Cambridge, Massachusetts); Tanya SHIRMAN (Arlington, Massachusetts); Katherine Reece PHILLIPS (Cambridge, Massachusetts); Elijah SHIRMAN (Arlington, Massachusetts); Theresa KAY (South Stoney Creek, Canada) |
| ABSTRACT | A co-assembly method for synthesizing inverse photonic structures is described. The method includes combining an onium compound with a sol-gel precursor to form metal oxide (MO) nanocrystals, where each MO nanocrystal has crystalline and amorphous content. The MO nanocrystals are combined with templating particles to form a suspension. A solvent is evaporated from the suspension to form an intermediate or compound product, which then undergoes calcination to produce an inverse structure. |
| FILED | Monday, December 06, 2021 |
| APPL NO | 17/543494 |
| CURRENT CPC | Separation B01D 39/2027 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/06 (20130101) B01J 20/08 (20130101) B01J 20/3085 (20130101) B01J 20/28007 (20130101) B01J 21/04 (20130101) B01J 21/063 (20130101) B01J 21/066 (20130101) B01J 35/004 (20130101) B01J 35/0013 (20130101) B01J 37/04 (20130101) B01J 37/0215 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Compounds of the Metals Beryllium, Magnesium, Aluminium, Calcium, Strontium, Barium, Radium, Thorium, or of the Rare-earth Metals C01F 7/02 (20130101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 23/047 (20130101) C01G 23/053 (20130101) C01G 25/02 (20130101) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2004/03 (20130101) C01P 2004/04 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 17/007 (20130101) C09D 17/008 (20130101) Starting of Combustion Engines; Starting Aids for Such Engines, Not Otherwise Provided for F02N 11/08 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/48 (20130101) H01M 4/9016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220250954 | CAMPBELL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Patrick CAMPBELL (Oakland, California); Maira Ceron HERNANDEZ (Brentwood, California); Steven HAWKS (Livermore, California); Colin LOEB (Fairfield, California); Tuan Anh PHAM (Livermore, California); Michael STADERMANN (Pleasanton, California) |
| ABSTRACT | The present disclosure relates to a method for making a carbon aerogel electrode material. The method involves initially making a wet organic sol-gel form. The sol-gel form is carbonized at a temperature of from about 900° C. to about 1000° C., for from about 2 hours to about 4 hours. The carbonized sol-gel is then activated under carbon dioxide flow, for from about 0.5 hour to about 1.5 hours, at from about 900° C. to about 1000° C. |
| FILED | Friday, April 29, 2022 |
| APPL NO | 17/733860 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/318 (20170801) C01B 32/336 (20170801) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2006/40 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/4691 (20130101) Original (OR) Class C02F 2101/163 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251120 | Hartmann-Thompson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | 3M INNOVATIVE PROPERTIES COMPANY (St. Paul, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Claire Hartmann-Thompson (Lake Elmo, Minnesota); Marina M. Kaplun (Woodbury, Minnesota) |
| ABSTRACT | A dihaloorganosilane is represented by the formula (I): Each X independently represents Cl, Br, or I. Each Ar1 independently represents a phenylene group optionally substituted by 1 to 4 alkyl groups selected from methyl or ethyl. Each R1 independently represents an alkylene group having from 2 to 18 carbon atoms. Each R2 independently represents methyl or ethyl. Each R3 independently represents an alkylene group having from 1 to 18 carbon atoms. Each R4 independently represents an alkylene group having from 2 to 18 carbon atoms, and n is an integer in a range of 0 to 5, inclusive. Ionic organosilanes preparable from the dihaloorganosilanes are represented by the formula (II): Membrane compositions and membranes containing the ionic organosilanes are also disclosed. |
| FILED | Friday, June 12, 2020 |
| APPL NO | 17/612469 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/081 (20130101) Original (OR) Class Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 212/08 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/5406 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251383 | Messman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jamie Michael Messman (Leawood, Kansas); Steven Michael Patterson (Kansas City, Missouri); Petar Dvornic (Midland, Michigan); Alisa Zlatanic (Dexter, Michigan); James Beach (Pittsburg, Kansas) |
| ABSTRACT | Shelf-stable, rapid crosslinking, “all-in-one” pastes useful as “inks” in additive manufacturing are provided. These pastes exhibit desirable rheological flow properties and crosslinking upon exposure to UV light. The pastes are based on vinylsilyl-functionalized, completely amorphous, linear terpolysiloxanes containing predominantly dimethylsiloxy- repeat units with small amounts of diphenylsiloxy-, methylphenylsiloxy-, diethylsiloxy-, and/or methyltrifluoroalkylsiloxy- crystallization disruptors. The base polymers are preferably compounded with a trimethylsilylated-hydrophobic silica filler, thixotropic flow agent, hydrosilyl-functionalized oligomeric crosslinker, and a catalytic system comprising platinum(II) acetylacetonate or trimethyl(methylcyclopentadienyl)-platinum(IV), and diethyl azodicarboxylate. |
| FILED | Thursday, March 04, 2021 |
| APPL NO | 17/192197 |
| CURRENT CPC | Compositions of Macromolecular Compounds C08L 83/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251384 | Messman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jamie Michael Messman (Leawood, Kansas); Steven Michael Patterson (Kansas City, Missouri); Petar Dvornic (Midland, Michigan); Alisa Zlatanic (Dexter, Michigan); James Beach (Pittsburg, Kansas) |
| ABSTRACT | Shelf-stable, rapid crosslinking, “all-in-one” pastes useful as “inks” in additive manufacturing are provided. These pastes exhibit desirable rheological flow properties and crosslinking upon exposure to UV light. The pastes are based on vinylsilyl-functionalized, completely amorphous, linear terpolysiloxanes containing predominantly dimethylsiloxy-repeat units with small amounts of diphenylsiloxy-, methylphenylsiloxy-, diethylsiloxy-, and/or methyltrifluoroalkylsiloxy-crystallization disruptors. The base polymers are preferably compounded with a trimethylsilylated-hydrophobic silica filler, thixotropic flow agent, hydrosilyl-functionalized oligomeric crosslinker, and a catalytic system comprising platinum(II) acetylacetonate or trimethyl(methylcyclopentadienyl)-platinum(IV), and diethyl azodicarboxylate. |
| FILED | Tuesday, May 11, 2021 |
| APPL NO | 17/317486 |
| CURRENT CPC | Compositions of Macromolecular Compounds C08L 83/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251443 | BEARD et al. |
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| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Craig BEARD (Arvada, Colorado); Haipeng LU (Hong Kong, China PRC); Yaxin ZHAI (Changsha, China PRC); Young-Hoon KIM (Seoul, South Korea); Joseph Jonathan BERRY (Boulder, Colorado); Joseph Matthew LUTHER (Boulder, Colorado) |
| ABSTRACT | Described herein are spin polarized light emitting diodes (LEDs) and methods of making the same. Spin polarization is achieved via chiral induced spin selectivity where, for example, a stereochemically active cation is included in a perovskite to form the conductive layer of an LED device. Advantageously, the devices and methods described herein allow for spin polarization at room temperature and without application of a magnetic field or ferromagnetic contacts, in contrast to other described spin selective LEDs. |
| FILED | Thursday, February 10, 2022 |
| APPL NO | 17/650582 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/665 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/56 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251500 | GUARNIERI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael T. GUARNIERI (Denver, Colorado); Lukas Royce DAHLIN (Golden, Colorado); Marcus Salvatore BRAY (Denver, Colorado) |
| ABSTRACT | Disclosed herein are methods and compositions for implementing a photosynthetic protein secretion platform. |
| FILED | Monday, February 07, 2022 |
| APPL NO | 17/666345 |
| CURRENT CPC | Peptides C07K 14/43595 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251573 | Liew et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | LanzaTech, Inc. (Skokie, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fungmin Liew (Chicago, Illinois); Michael Koepke (Chicago, Illinois) |
| ABSTRACT | Microorganisms are genetically engineered to produce 3-hydroxypropionate (3-HP). The microorganisms are carboxydotrophic acetogens. The microorganisms produce acetyl-coA using the Wood-Ljungdahl pathway for fixing CO/CO2. A β-alanine pyruvate aminotransferase from a microorganism that contains such an enzyme is introduced. Additionally, an acetyl-coA carboxylase may also be introduced. The production of 3-HP can be improved. This can be effected by improved promoters or higher copy number or enzymes that are catalytically more efficient. |
| FILED | Monday, February 07, 2022 |
| APPL NO | 17/650191 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0006 (20130101) C12N 9/0008 (20130101) C12N 9/93 (20130101) C12N 9/1096 (20130101) C12N 15/52 (20130101) Original (OR) Class C12N 15/74 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/18 (20130101) C12P 7/42 (20130101) Enzymes C12Y 101/01001 (20130101) C12Y 102/01075 (20130101) C12Y 102/07005 (20130101) C12Y 206/01018 (20130101) C12Y 604/01002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251597 | KOZY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PIONEER HI-BRED INTERNATIONAL, INC. (Johnston, Iowa) |
| ASSIGNEE(S) | PIONEER HI-BRED INTERNATIONAL, INC. (JOHNSTON, Iowa) |
| INVENTOR(S) | HEATHER KOZY (WALNUT CREEK, California); JARRED KENNETH ORAL (JOHNSTON, Iowa); UTE SCHELLENBERGER (PALO ALTO, California); JUN-ZHI WEI (JOHNSTON, Iowa); WEIPING XIE (EAST PALO ALTO, California); XIAOHONG ZHONG (SAN LEANDRO, California); GENHAI ZHU (SAN JOSE, California) |
| ABSTRACT | Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity. |
| FILED | Thursday, January 27, 2022 |
| APPL NO | 17/585983 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 47/44 (20130101) Peptides C07K 14/21 (20130101) C07K 14/24 (20130101) C07K 14/245 (20130101) C07K 2319/00 (20130101) C07K 2319/21 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8242 (20130101) C12N 15/8286 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251617 | Arlow et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Daniel Arlow (Berkeley, California); Sebastian Palluk (Berkeley, California) |
| ABSTRACT | Provided herein, among other things, is a conjugate comprising a polymerase and a nucleoside triphosphate, where the polymerase and the nucleoside triphosphate are covalently linked via a linker that comprises a cleavable linkage. A set of such conjugates, where the conjugates correspond to G, A, T (or U) and C is also provided. Methods for synthesizing a nucleic acid of a defined sequence are also provided. The conjugates can also be used for sequencing applications. |
| FILED | Wednesday, March 09, 2022 |
| APPL NO | 17/691029 |
| CURRENT CPC | Peptides C07K 19/00 (20130101) C07K 2319/21 (20130101) C07K 2319/24 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1241 (20130101) C12N 9/1252 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) C12Q 1/6874 (20130101) C12Q 1/6876 (20130101) Enzymes C12Y 207/07 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251674 | Ding et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Jie Ding (Dalian, China PRC); Qiang Li (Ames, Iowa); Zhongxia Shang (Lafayette, Indiana); Xinghang Zhang (West Lafayette, Indiana) |
| ABSTRACT | A method of strengthening a component made of a metallic material. The method includes subjecting the component to a mechanical grinding process incorporating a relative motion between a tool and the component forming a gradient structure on the surface of the component, resulting in increased tensile strength of the component. A method of strengthening a component made of a TWIP steel. The method includes subjecting the component made of TWIP steel to a mechanical grinding process incorporating a relative motion between a tool and the component forming a gradient structure containing a surface nanolaminate layer, a shear band layer, and an inner deformation twinned layer, resulting in increased tensile strength of the component. A component made of a TWIP steel containing a gradient structure with a surface nanolaminate layer, a shear band layer, and a deformation twinned layer. |
| FILED | Wednesday, April 27, 2022 |
| APPL NO | 17/730557 |
| CURRENT CPC | Planing; Slotting; Shearing; Broaching; Sawing; Filing; Scraping; Like Operations for Working Metal by Removing Material, Not Otherwise Provided for B23D 61/026 (20130101) Machines, Devices, or Processes for Grinding or Polishing; Dressing or Conditioning of Abrading Surfaces; Feeding of Grinding, Polishing, or Lapping Agents B24B 1/00 (20130101) Modifying the Physical Structure of Ferrous Metals; General Devices for Heat Treatment of Ferrous or Non-ferrous Metals or Alloys; Making Metal Malleable, e.g by Decarburisation or Tempering C21D 7/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251690 | Muralidharan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-BATTELLE, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Govindarajan Muralidharan (Knoxville, Tennessee); Michael P. Brady (Oak Ridge, Tennessee); Yukinori Yamamoto (Knoxville, Tennessee) |
| ABSTRACT | An austenitic Ni-base alloy, consisting essentially of, in weight percent: 2.5 to 4.75 Al; 21 to 26 Cr; 20 to 40 Fe; 0.75 to 2.5 total of at least one element elected from the group consisting of Nb and Ta; 0 to 0.25 Ti; 0.09 to 1.5 Si; 0 to 0.5 V; 0 to 2 Mn; 0 to 3 Cu; 0 to 2 of at least one element selected from the group consisting of Mo and W; 0 to 1 of at least one element selected from the group consisting of Zr and Hf; 0 to 0.15 Y; 0.3 to 0.55 C; 0.005 to 0.1 B; 0 to 0.05 P; less than 0.06 N and balance Ni (30 to 46 Ni), wherein the weight percent Ni is greater than the weight percent Fe, wherein the ratio Ni/(Fe+2*C) is between 0.95 and 1.0735, with a scale comprising alumina, a stable phase FCC austenitic matrix microstructure, carbide strengthening phases, and with a creep rupture lifetime of at least 100 h at 900° C. and 50 MPa. |
| FILED | Friday, January 29, 2021 |
| APPL NO | 17/162917 |
| CURRENT CPC | Alloys C22C 30/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251728 | SHIN |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | YoungHo SHIN (LaGrange Highlands, Illinois) |
| ABSTRACT | The invention provides a battery material comprising-monocrystalline particles not having internal void fractions, wherein each of the monocrystalline particles is without internal grain boundaries such that anisotropic volume change issues of polycrystalline particles don't occur when the particles are charged and discharged during cycling. Also provided is the monocrystalline particles with less-lithium on the particle surface. Also provided is a method for preparing monocrystalline battery material, wherein the battery material may be incorporated into a secondary battery. |
| FILED | Monday, February 08, 2021 |
| APPL NO | 17/170057 |
| CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 29/22 (20130101) Original (OR) Class Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 10/0525 (20130101) H01M 2004/021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220252036 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Jun Chen (West Lafayette, Indiana); Haiyan H. Zhang (West Lafayette, Indiana); Charles Greg Jensen (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jun Chen (West Lafayette, Indiana); Haiyan H. Zhang (West Lafayette, Indiana); Charles Greg Jensen (West Lafayette, Indiana) |
| ABSTRACT | A hydrokinetic turbine system for harvesting energy from riverine and tidal sources, including a first floating dock, a marine hydrokinetic turbine mounted on the first floating dock, and a second floating dock. The system further includes a winch assembly mounted on the second floating dock and operationally connected to the first floating dock and a linkage assembly operationally connected to the first floating dock and to the second floating dock. The linkage assembly may be actuated to pull the first floating dock into contact with the second floating dock. The linkage assembly may be actuated to distance the first floating dock from the second floating dock, and the winch assembly may be energized to orient the first floating dock into a position wherein the marine hydrokinetic turbine is above the first floating dock and wherein the winch assembly may be energized to orient the first floating dock into a position wherein the marine hydrokinetic turbine is below the first floating dock. |
| FILED | Monday, January 10, 2022 |
| APPL NO | 17/572232 |
| CURRENT CPC | Ships or Other Waterborne Vessels; Equipment for Shipping B63B 1/28 (20130101) B63B 21/16 (20130101) B63B 35/44 (20130101) B63B 2035/4466 (20130101) Machines or Engines for Liquids F03B 3/145 (20130101) Original (OR) Class Indexing Scheme Relating to Wind, Spring, Weight, Inertia or Like Motors, to Machines or Engines for Liquids Covered by Subclasses F03B, F03D and F03G F05B 2220/32 (20130101) F05B 2240/93 (20130101) F05B 2240/95 (20130101) F05B 2260/70 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220252039 | Wilson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico); Michigan Technological University (Houghton, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David G. Wilson (Tijeras, New Mexico); Rush D. Robinett, III (Tijeras, New Mexico); Wayne W. Weaver (Hancock, Michigan); Steven F. Glover (Albuquerque, New Mexico) |
| ABSTRACT | A nonlinear control design technique capitalizes on a wave energy converter comprising a shaped buoy having a variable geometry wave energy. For example, the shaped buoy can have an hourglass (HG) geometry having a variable cone or steepness angle. The HG buoy is assumed to operate in the heave motion of the wave. The unique interaction between the HG buoy and the wave creates a nonlinear cubic storage effect that produces actual energy storage or reactive power during operation. A multi-frequency Bretschneider spectrum wave excitation input was simulated for the HG design both with constant and varying steepness angle profiles which demonstrated further increased power generation with changing sea states for the variable design. |
| FILED | Tuesday, April 19, 2022 |
| APPL NO | 17/723690 |
| CURRENT CPC | Machines or Engines for Liquids F03B 13/20 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220252058 | Van de Ven et al. |
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| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota); WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Van de Ven (Minneapolis, Minnesota); Garrett Bohach (Minneapolis, Minnesota); First Name Unknown Nishanth (Madison, Wisconsin); Eric Severson (Middleton, Wisconsin) |
| ABSTRACT | An electric-to-hydraulic conversion machine includes an axial flux electric motor and a hydraulic pump. The motor includes a spindle, at least one rotor configured to rotate about the spindle, and at least one stator configured to drive rotation of the at least one rotor about the spindle. The hydraulic pump includes a piston block having a plurality of cylinders, a plurality of pistons each supported in one of the cylinders of the piston block, and a cam ring. The piston block is attached to the at least one rotor and is configured to rotate about the spindle with rotation of the at least one rotor. The cam ring is configured to radially drive the pistons during rotation of the piston block about the spindle, which drives a fluid flow. |
| FILED | Friday, August 14, 2020 |
| APPL NO | 17/629909 |
| CURRENT CPC | Positive-displacement Machines for Liquids; Pumps F04B 1/0452 (20130101) F04B 1/0472 (20130101) F04B 7/0007 (20130101) F04B 17/03 (20130101) Original (OR) Class Dynamo-electric Machines H02K 1/2793 (20130101) H02K 7/14 (20130101) H02K 16/02 (20130101) H02K 21/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220252088 | Vacca et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrea Vacca (West Lafayette, Indiana); Shaoyang Qu (West Lafayette, Indiana) |
| ABSTRACT | An electro-hydraulic actuator system includes a fixed-displacement hydraulic pump and a variable speed electric motor configured in combination to constitute an individual electro-hydraulic unit that is coupled to an actuator, and a bypass valve in parallel to the actuator. The system is configured to enable the actuator to be operated at actuation speeds that are higher than a maximum actuation capability of the pump at the maximum flow capability thereof, and at actuation speeds that are lower than a minimum actuation capability of the pump at the minimum flow capability thereof. The actuation velocity of the actuator may be controlled by controlling the speed of the electro-hydraulic unit and a size of an opening of the bypass valve. |
| FILED | Wednesday, February 09, 2022 |
| APPL NO | 17/667680 |
| CURRENT CPC | Systems Acting by Means of Fluids in General; Fluid-pressure Actuators, e.g Servomotors; Details of Fluid-pressure Systems, Not Otherwise Provided for F15B 11/044 (20130101) F15B 15/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220252308 | Ihnfeldt et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Engineering and Research, L.L.C. (San Diego, California); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robin Ihnfeldt (San Diego, California); Renkun Chen (San Diego, California); Sungho Jin (San Diego, California); Tianshi Feng (La Jolla, California); Sarath Adapa (Oakland, California) |
| ABSTRACT | Systems and methods disclosed herein relate to a cryogenic refrigeration system which may use a compression based cryocooler or liquid nitrogen pre-cool to cool a medium to ˜80K, and may in conjunction with a magnetic refrigeration system operating in the sub-80K temperature regime to provide cooling to a medium to temperatures below 80K. In some embodiments, the disclosed system may be useful for cooling on the order of about 3 kg/day to about 300 kg/day of hydrogen gas to liquid form, with higher efficiency than a standard vapor compression based system. This higher efficiency may make the system a more attractive candidate for use in cryogenic cooling applications. |
| FILED | Tuesday, July 28, 2020 |
| APPL NO | 17/630443 |
| CURRENT CPC | Refrigeration Machines, Plants or Systems; Combined Heating and Refrigeration Systems; Heat-pump Systems F25B 21/00 (20130101) Original (OR) Class F25B 2321/002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220252309 | Yu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| INVENTOR(S) | Nanfang Yu (Fort Lee, New Jersey); Jyotirmoy Mandal (New York, New York); Adam Overvig (New York, New York); Norman Nan Shi (San Jose, California); Meng Tian (Fort Lee, New Jersey) |
| ABSTRACT | Systems and methods for radiative cooling and heating are provided. For example, systems for radiative cooling can include a top layer including one or more polymers, where the top layer has high emissivity in at least a portion of the thermal spectrum and an electromagnetic extinction coefficient of approximately zero, absorptivity of approximately zero, and high transmittance in at least a portion of the solar spectrum, and further include a reflective layer including one or more metals, where the reflective layer has high reflectivity in at least a portion of the solar spectrum. |
| FILED | Monday, March 21, 2022 |
| APPL NO | 17/699789 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 27/18 (20130101) B32B 27/283 (20130101) B32B 33/00 (20130101) Solar Heat Collectors; Solar Heat Systems F24S 10/40 (20180501) F24S 70/30 (20180501) F24S 70/60 (20180501) F24S 70/225 (20180501) Refrigeration Machines, Plants or Systems; Combined Heating and Refrigeration Systems; Heat-pump Systems F25B 23/003 (20130101) Original (OR) Class Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 2245/06 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/44 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220252457 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | The Texas A and M University System (College Station, Texas) |
| INVENTOR(S) | Ya Wang (Los Altos, California); Libo Wu (College Station, Texas); Zhangjie Chen (College Station, Texas) |
| ABSTRACT | A passive infrared (PIR) sensor system, includes a PIR sensor configured to produce an output signal in response to receiving infrared (IR) radiation, an electronic shutter positionable in a field of view (FOV) of the PIR sensor, wherein the electronic shutter includes a liquid crystal (LC) material, wherein the electronic shutter includes a first state providing a first transmissivity of IR radiation through the electronic shutter and a second state providing a second transmissivity of IR radiation through the electronic shutter that is less than the first transmissivity, and a shutter actuator configured to apply an actuation signal to the electronic shutter to actuate the electronic shutter between the first state and the second state. |
| FILED | Friday, June 19, 2020 |
| APPL NO | 17/620619 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 5/0025 (20130101) G01J 5/0804 (20220101) Original (OR) Class G01J 5/0875 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220252530 | Fuka et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Microbeam Technologies, Inc. (Grand Forks, North Dakota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Fuka (Grand Forks, North Dakota); Eric Kolb (Grand Forks, North Dakota); Alexander Benson (Denver, Colorado); Steven Benson (Victoria, Minnesota) |
| ABSTRACT | A system for predicting rare earth elements (REEs) in a feedstock sample includes a measurement instrument that records a measurement for a sample, a processor communicatively coupled to the measuring instrument, and a memory communicatively coupled to the processor and containing machine readable instructions that, when executed by the processor, cause the processor to correlate the measurement series using a model; and predict a presence of one or more rare earth element based at least in part on the correlation. A method for predicting rare earth elements includes measuring feedstock samples via XRF or PGNAA, to generate a measurements of elements of interest with a lower atomic weight than REEs; correlating the measurements with a model; and predicting a presence of one or more rare earth elements based at least in part on the correlation. |
| FILED | Friday, February 11, 2022 |
| APPL NO | 17/650773 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/222 (20130101) Original (OR) Class G01N 23/223 (20130101) G01N 33/2858 (20130101) G01N 2223/076 (20130101) G01N 2223/301 (20130101) G01N 2223/305 (20130101) G01N 2223/616 (20130101) G01N 2223/617 (20130101) G01N 2223/0745 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220252536 | Chatterjee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington); New Jersey Institute of Technology (Newark, New Jersey) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington); New Jersey Institute of Technology (Newark, New Jersey) |
| INVENTOR(S) | Sayandev Chatterjee (Richland, Washington); Radha K. Motkuri (Richland, Washington); Sagnik Basuray (Parsippany, New Jersey); Yu Hsuan Cheng (Harrison, New Jersey) |
| ABSTRACT | Materials for binding per- and polyfluoroalkyl substances (PFAS) are disclosed. A fluidic device comprising the materials for detection and quantification of PFAS in a sample is disclosed. The fluidic device may be configured for multiplexed analyses. Also disclosed are methods for sorbing and remediating PFAS in a sample. The sample may be groundwater containing, or suspected of containing, one or more PFAS. |
| FILED | Thursday, May 07, 2020 |
| APPL NO | 17/613807 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/226 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/32 (20130101) C02F 1/281 (20130101) C02F 1/283 (20130101) C02F 1/285 (20130101) C02F 1/288 (20130101) C02F 1/583 (20130101) C02F 1/725 (20130101) C02F 2101/36 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/07 (20130101) G01N 27/48 (20130101) G01N 27/226 (20130101) Original (OR) Class G01N 33/1886 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220252642 | Kulkarni et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shreyas Bhalchandra Kulkarni (Atlanta, Georgia); Deepakraj M Divan (Atlanta, Georgia) |
| ABSTRACT | An exemplary embodiment provides a current sensor comprising a printed circuit board (PCB), a Rogowski coil, and a controller. The PCB can comprise an aperture configured to receive a conductor carrying an alternating electrical current. The Rogowski coil can be positioned on the PCB along a perimeter of the aperture. The controller can be in electrical communication with the Rogowski coil and configured to generate an output signal indicative of the alternating electric current carried by the conductor. The current sensor can be configured to measure the alternating electric current relative to a full scale at a resolution of 1000:1 and at an accuracy within 1%, wherein the full scale can range over 5000:1. |
| FILED | Wednesday, July 29, 2020 |
| APPL NO | 17/597902 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 15/181 (20130101) Original (OR) Class G01R 19/0092 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220252731 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wayne State University (Detroit, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wen Li (Troy, Michigan); Suk Kyoung Lee (Troy, Michigan); Gabriel Stewart (Grosse Pointe Park, Michigan); Duke Debrah (Detroit, Michigan) |
| ABSTRACT | A source emits a pulse to an object to generate a particle, and an imaging detector produces a light flash at an X/Y hit position of the particle. The detector outputs a waveform arising from the particle. An event-driven camera provides a signal from the detector that includes intensity and time-over-threshold signals related to the light flash, time-of-arrival information of the event, and the X and Y hit position of the particle. A photodiode determines a time origin of the pulse from the source. A timing circuit is coupled to the detector and to the photodiode, and determines time-of-flight (TOF) of the particle based on the waveform, and based on the time origin of the pulse. The 3D coordinates are generated based on the X/Y hit position synchronized with the TOF of the particle. |
| FILED | Tuesday, February 08, 2022 |
| APPL NO | 17/667148 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/4865 (20130101) G01S 7/4915 (20130101) G01S 17/06 (20130101) G01S 17/894 (20200101) Original (OR) Class Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/11 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220252761 | XIA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaoxing XIA (Pleasanton, California); Eyal FEIGENBAUM (Livermore, California) |
| ABSTRACT | A metalens array is disclosed for controllably modifying a phase of a wavefront of an optical beam. The metalens array may have a substrate having at least first and second metalens unit cells, and forming a single integrated structure with no stitching being required of the first and second metalens unit cells. The first metalens unit cell has a first plurality of nanoscale features and is configured to modify a phase of a first portion of a wavefront of an optical signal incident thereon in accordance with a first predetermined phase pattern to create at least one first focal voxel within an image plane. The second metalens unit cell has a second plurality of nanoscale features configured to modify the phase of a second portion of the wavefront of the optical signal incident thereon, in accordance with a second predetermined phase pattern, to simultaneously create at least one second focal voxel within the image plane. Each metalens unit cell also has an overall diameter of no more than about 200 microns. |
| FILED | Friday, February 05, 2021 |
| APPL NO | 17/168743 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 1/002 (20130101) Original (OR) Class G02B 2207/101 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/0037 (20130101) G03F 7/70275 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220255165 | Beck et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Victor Alfred Beck (Livermore, California); Sarah Baker (Dublin, California); Jonathan Tesner Davis (Oakland, California); Eric Duoss (Dublin, California); Daniel Tortorelli (Champaign, Illinois); Seth Evan Watts (Collingswood, New Jersey); Marcus A. Worsley (Hayward, California) |
| ABSTRACT | Disclosed are electrochemical reactors with electrodes that have variable porosity across the electrode. The electrodes are designed and micro-architected to have variable porosity and 3D flow. In one aspect, an electrochemical cell apparatus is disclosed. The apparatus includes an electrochemical vessel and an electrochemical fluid contained in the electrochemical vessel. The apparatus further includes a porous electrode submerged in the electrochemical fluid in the electrochemical vessel, the porous electrode having different porosities in different areas of the porous electrode. The different porosities inhibit electrochemical fluid flow and increase electrical conductivity in first areas of the porous electrode with decreased porosity compared to second areas, and enable increased electrochemical fluid flow and decrease electrical conductivity in the second areas of the porous electrode with increased porosity compared to the first areas. |
| FILED | Tuesday, February 08, 2022 |
| APPL NO | 17/667489 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/04 (20130101) H01M 10/6561 (20150401) H01M 10/6568 (20150401) Original (OR) Class H01M 2004/021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220255187 | Dharmasena et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GM GLOBAL TECHNOLOGY OPERATIONS LLC (Detroit, Michigan) |
| ASSIGNEE(S) | GM GLOBAL TECHNOLOGY OPERATIONS LLC (Detroit, Michigan) |
| INVENTOR(S) | Ruchira R. Dharmasena (Shelby Township, Michigan); Shuru Chen (Troy, Michigan); Fang Dai (Troy, Michigan); Mei Cai (Bloomfield Hills, Michigan) |
| ABSTRACT | A method for coating a separator for a battery includes creating an electrostatic field and disposing a substrate material within the electrostatic field. The method further includes applying a coating material to the substrate material in a presence of the electrostatic field and drying the coating material upon the substrate material. |
| FILED | Wednesday, February 10, 2021 |
| APPL NO | 17/172609 |
| CURRENT CPC | Processes for Applying Fluent Materials to Surfaces, in General B05D 1/007 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 50/403 (20210101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220255463 | Bekker et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Logan Bekker (Pleasanton, California); Caitlyn C. Cook (Livermore, California); Joshua D. Kuntz (Livermore, California); Elaine Lee (Oakland, California); Erik V. Mukerjee (Dublin, California); Andrew J. Pascall (Livermore, California); Marcus A. Worsley (Hayward, California); Jenny Zhou (San Francisco, California) |
| ABSTRACT | A triboelectric device artificial air gap between the two materials to create the voltage potential. A method of using a flexible, compressive material as a spacer to create an artificial air gap that will allow the two materials to transfer electrons and provide a restorative force to separate the two materials when pressed together. The result is a device that does not require an air gap to generate a voltage potential, which in turn reduces the necessary footprint of the triboelectric device to a thin film and improves its mechanical robustness and lifetime. |
| FILED | Wednesday, May 05, 2021 |
| APPL NO | 17/308627 |
| CURRENT CPC | Electric Machines Not Otherwise Provided for H02N 1/04 (20130101) Original (OR) Class H02N 1/006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220255503 | Marti et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shilpa Marti (Oak Ridge, Tennessee); Rafal P. Wojda (Oak Ridge, Tennessee); Suman Debnath (Oak Ridge, Tennessee) |
| ABSTRACT | A system for evaluating a power electronics module, such as a photovoltaic (PV) module or an energy-storage system (ESS) module, is provided. The power electronics module may form a component of a multiport autonomous reconfigurable solar (MARS) power plant, which may include a plurality of phase-legs each including an upper arm and the lower arm. |
| FILED | Tuesday, February 08, 2022 |
| APPL NO | 17/666949 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 21/06 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/01 (20130101) H02J 3/381 (20130101) H02J 2300/24 (20200101) Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 3/155 (20130101) Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 50/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220256173 | TOHLEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | HONEYWELL FEDERAL MANUFACTURING and TECHNOLOGIES, LLC (KANSAS CITY, Missouri) |
| ASSIGNEE(S) | HONEYWELL FEDERAL MANUFACTURING and TECHNOLOGIES, LLC (KANSAS CITY, Missouri) |
| INVENTOR(S) | MICHAEL AARON TOHLEN (LEE'S SUMMIT, Missouri); MITCHELL HEDGES MORROW (OVERLAND PARK, Kansas); JOSHUA J. MILLER (OVERLAND PARK, Kansas) |
| ABSTRACT | A computer-implemented method for compressing video data comprises receiving a sequence of video data values, each video data value being a digital value from a successive one of a plurality of pixels that form a video sensor, the sequence of video data values resulting from successive frames of video captured by the video sensor; extracting the video data values for each pixel in turn to create a plurality of pixel data streams, each pixel data stream including the video data value for each frame of captured video for the pixel; and applying data compression to each pixel data stream to create compressed data for each pixel data stream. |
| FILED | Wednesday, March 30, 2022 |
| APPL NO | 17/708542 |
| CURRENT CPC | Pictorial Communication, e.g Television H04N 19/132 (20141101) H04N 19/136 (20141101) H04N 19/172 (20141101) H04N 19/182 (20141101) H04N 19/184 (20141101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220256682 | DOBRYNIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DREXEL UNIVERSITY (PHILADELPHIA, Pennsylvania); Thomas Jefferson University (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | Drexel University (Philadelphia, Pennsylvania); Thomas Jefferson University (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Danil V. DOBRYNIN (Philadelphia, Pennsylvania); Alexander FRIDMAN (Philadelphia, Pennsylvania); Abraham LIN (Ann Arbor, Michigan); Vandana MILLER (Philadelphia, Pennsylvania); Adam Snook (Aston, Pennsylvania) |
| ABSTRACT | Applications of dielectric barrier discharge (DBD) based atmospheric pressure plasma jets are often limited by the relatively small area of treatment due to their 1D configuration. This system generates 2D plasma jets permitting fast treatment of larger targets. DBD evolution starts with formation of transient anode glow, and continues with development of cathode-directed streamers. The anode glow can propagate as an ionization wave along the dielectric surface through and outside of the discharge gap. Plasma propagation is not limited to 1D geometry such as tubes, and can be organized in a form of a rectangular plasma jet, or other 2D or 3D shapes. Also described are a method for generating 2D plasma jets and use of the 2D plasma jets for cancer therapy. |
| FILED | Monday, January 03, 2022 |
| APPL NO | 17/567424 |
| CURRENT CPC | Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 1/2406 (20130101) Original (OR) Class H05H 1/2443 (20210501) H05H 2240/20 (20130101) H05H 2245/30 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20220248676 | Finn et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GEORGIA TECH RESEARCH CORPORATION (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | M.G. Finn (Atlanta, Georgia); Jennifer Marie Beveridge (Atlanta, Georgia); Allison Geoghan Aioub (Atlanta, Georgia); Zhishuai Geng (Atlanta, Georgia) |
| ABSTRACT | Disclosed are antimicrobial articles and surfaces, as well as methods of making such articles and surfaces. |
| FILED | Friday, January 07, 2022 |
| APPL NO | 17/570976 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 25/10 (20130101) A01N 43/40 (20130101) A01N 43/46 (20130101) A01N 43/90 (20130101) Original (OR) Class Heterocyclic Compounds C07D 495/08 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 8/32 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220248983 | Roxbury et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Rhode Island Board of Trustees (Kingston, Rhode Island) |
| ASSIGNEE(S) | University of Rhode Island Board of Trustees (Kingston, Rhode Island) |
| INVENTOR(S) | Daniel Roxbury (Warwick, Rhode Island); Mohammad Moein Safaee (Kingston, Rhode Island); Mitchell Gravely (North Kingstown, Rhode Island) |
| ABSTRACT | An optical core-shell microfibrous textile incorporates single-walled carbon nanotubes (SWCNTs) for the real-time optical monitoring of hydrogen peroxide concentrations and other biochemicals in in vitro wounds. The environmentally sensitive and non-photo-bleachable fluorescence of SWCNTs enable continuous analyte monitoring without a decay in signal over time. The microfibrous textiles spatially resolve chemical indicator concentrations using a camera and are integrated into commercial wound bandages without significant degradation in their optical properties. |
| FILED | Tuesday, February 01, 2022 |
| APPL NO | 17/590032 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/445 (20130101) A61B 5/1455 (20130101) Original (OR) Class A61B 5/14546 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 13/00 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/041 (20170501) Compositions of Macromolecular Compounds C08L 67/04 (20130101) C08L 71/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249000 | Lu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nanshu Lu (Austin, Texas); Shixuan Yang (Austin, Texas); Pulin Wang (Austin, Texas) |
| ABSTRACT | Epidermal electronics are non-invasive and non-obstructive skin mounted sensors with mechanical properties matching human epidermis. Their manufacturing process includes photolithography and dry and wet etching within cleanroom facilities. The high cost of manpower, materials, photo masks, and facilities greatly hinders the commercialization potential of disposable epidermal electronics. In contrast, an embodiment of the invention includes a low cost, high throughput, bench top “cut-and-paste” method to complete the freeform manufacture of epidermal sensor system (ESS) in minutes. This versatile method works for many types of thin metal and polymeric sheets and is compatible with many tattoo adhesives or medical tapes. The resultant ESS is highly multimaterial and multifunctional and may measure ECG, EMG, skin temperature, skin hydration, as well as respiratory rate. Also, a stretchable planar coil made of serpentine ribbons can be used as a wireless strain gauge and/or a near field communication (NFC) antenna. Other embodiments are described herein. |
| FILED | Tuesday, April 26, 2022 |
| APPL NO | 17/729768 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/01 (20130101) A61B 5/25 (20210101) Original (OR) Class A61B 5/085 (20130101) A61B 5/296 (20210101) A61B 5/0537 (20130101) A61B 5/6833 (20130101) A61B 2562/02 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 35/02 (20130101) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2031/753 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249008 | LI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Adam LI (Thousand Oaks, California); Sridevi V. SARMA (McLean, Virginia) |
| ABSTRACT | A device may receive electroencephalography data relating to one or more cerebral regions. The device may generate, based on the electroencephalography data, a cortical stimulation mapping model of the one or more cerebral regions, wherein the cortical stimulation mapping model includes one or more virtual inputs and one or more virtual outputs corresponding to the one or more cerebral regions. The device may apply a virtual impulse to the one or more virtual inputs. The device may determine a virtual after-discharge from the one or more virtual outputs, wherein the virtual after-discharge includes information relating to an electrical response to the virtual impulse. The device may generate, based on the virtual after-discharge, an index that maps a magnitude of the virtual after-discharge to the one or more cerebral regions. The device may cause an action to be performed based on the index. |
| FILED | Friday, July 17, 2020 |
| APPL NO | 17/597211 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/372 (20210101) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 40/60 (20180101) G16H 50/20 (20180101) G16H 50/50 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249672 | Jeffries et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric M. Jeffries (West New York, New Jersey); Yadong Wang (Bradford Woods, Pennsylvania); Daniel Long (Pittsburgh, Pennsylvania); Noah R. Johnson (Pittsburgh, Pennsylvania) |
| ABSTRACT | Compositions are provided herein comprising a coacervate of a polycationic polymer, a polyanionic polymer, and platelet-rich plasma and/or serum, or a fraction or concentrate thereof. The composition is useful in wound healing. Compositions also are provided that comprise a hydrogel comprising TIMP-3; and a complex of a polycationic polymer, a polyanionic polymer, FGF-2 and SDF-1α embedded in the hydrogel, which is useful in treating a myocardial infarction. |
| FILED | Tuesday, November 23, 2021 |
| APPL NO | 17/533958 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/0019 (20130101) A61K 35/16 (20130101) A61K 35/19 (20130101) A61K 38/18 (20130101) A61K 38/177 (20130101) A61K 38/195 (20130101) A61K 38/1825 (20130101) A61K 47/34 (20130101) A61K 47/36 (20130101) Original (OR) Class A61K 47/42 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 15/40 (20130101) A61L 15/44 (20130101) A61L 15/225 (20130101) A61L 27/18 (20130101) A61L 27/20 (20130101) A61L 27/26 (20130101) A61L 27/52 (20130101) A61L 27/54 (20130101) A61L 27/56 (20130101) A61L 27/225 (20130101) A61L 27/3616 (20130101) A61L 31/16 (20130101) A61L 31/041 (20130101) A61L 31/042 (20130101) A61L 31/046 (20130101) A61L 31/145 (20130101) A61L 2300/25 (20130101) A61L 2300/252 (20130101) A61L 2300/414 (20130101) A61L 2300/418 (20130101) A61L 2400/04 (20130101) A61L 2430/20 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249696 | Green et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jordan J. Green (Baltimore, Maryland); Kelly Rhodes (Baltimore, Maryland); Randall A. Meyer (Baltimore, Maryland); Stephany Yi Tzeng (Baltimore, Maryland) |
| ABSTRACT | Biodegradable particles for interacting with immune cells to generate an immunosuppressive effect are disclosed. The biodegradable particle comprises a polyester or polyester blend with at least one soluble protein or small molecule encapsulated within the particle and at least two types of protein attached to a surface of the particle or to a coating on the surface thereof, which can be used to induce targeting regulatory T cells (Tregs). The at least two types of protein attached to a surface of the particle or to a coating on the surface thereof include a “Signal 1” protein that binds to an immune cell and a “Signal 2” protein that acts as a co-stimulatory molecule to immune cells. The encapsulated protein can be an interleukin and/or a cytokine. Methods of their use for treating a disease or condition, including an autoimmune disease, are disclosed. |
| FILED | Friday, June 12, 2020 |
| APPL NO | 17/602932 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/436 (20130101) A61K 38/1841 (20130101) A61K 39/0008 (20130101) A61K 47/646 (20170801) A61K 47/6425 (20170801) A61K 47/6849 (20170801) A61K 47/6937 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249719 | Westerhoff et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Paul K. Westerhoff (Scottsdale, Arizona); Zhe Zhao (Tempe, Arizona); Nora Shapiro (Tempe, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul K. Westerhoff (Scottsdale, Arizona); Zhe Zhao (Tempe, Arizona); Nora Shapiro (Tempe, Arizona) |
| ABSTRACT | A coated optical fiber includes an optical fiber having a core and an outer surface, and a homogeneous polymer coating in contact with the outer surface of the optical fiber. The optical fiber and the homogeneous polymer coating are UV transparent, and a refractive index of the outer surface of the optical fiber or the homogeneous polymer coating is up to 15% less than a refractive index of the core. Coating the optical fiber includes coating an outer surface with a polymerizable material and polymerizing the polymerizerable material to yield the coated optical fiber having a homogeneous polymer coating. The optical fiber and the homogeneous polymer coating are UV transparent, and a refractive index of the outer surface of the optical fiber or the homogeneous polymer coating is up to 15% less than a refractive index of a core of the optical fiber. |
| FILED | Tuesday, February 08, 2022 |
| APPL NO | 17/667283 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 2/10 (20130101) Original (OR) Class A61L 2202/11 (20130101) Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials C03C 25/105 (20130101) C03C 25/305 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 147/00 (20130101) Optical Elements, Systems, or Apparatus G02B 6/001 (20130101) G02B 6/0006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220249817 | Zhao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Renee Zhao (Columbus, Ohio); Shuai Wu (Columbus, Ohio); Qiji Ze (Columbus, Ohio) |
| ABSTRACT | Described herein are unit cells including a base plate; a top plate; and a lumen extending longitudinally from the base plate to the top plate, the lumen defined by a side wall formed from a plurality of cojoined panels extending between a bottom surface of the top plate and a top surface of the base plate. The unit cell can be magnetically actuatable, such that the unit cell can be reversibly transitioned between a contracted configuration, an extended configuration, or a combination thereof using an applied magnetic field. |
| FILED | Monday, January 31, 2022 |
| APPL NO | 17/589609 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0009 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 37/00 (20130101) Original (OR) Class A61M 2205/0288 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220250913 | Tse et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen D. Tse (Warren, New Jersey); Hua Hong (Weehawken, New Jersey); Bernard H. Kear (Whitehouse Station, New Jersey) |
| ABSTRACT | Methods for the production of carbon-based and other nanostructures are provided. |
| FILED | Friday, December 17, 2021 |
| APPL NO | 17/554293 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/184 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220250934 | Kaner et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Richard Barry Kaner (Pacific Palisades, California); Georgiy Akopov (Greenwood, South Carolina); Michael Tyrone Yeung (Los Angeles, California); Christopher Lawrence Turner (Lancaster, California); Zachary C. Sobell (Menlo Park, California); Cheng-Wei Lin (Los Angeles, California) |
| ABSTRACT | Disclosed herein, in certain embodiments, are compounds, methods, tools, and abrasive materials comprising mixed transition metal dodecaborides. |
| FILED | Friday, September 17, 2021 |
| APPL NO | 17/478647 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 35/04 (20130101) Compounds of the Metals Beryllium, Magnesium, Aluminium, Calcium, Strontium, Barium, Radium, Thorium, or of the Rare-earth Metals C01F 17/30 (20200101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 25/006 (20130101) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/30 (20130101) C01P 2002/52 (20130101) C01P 2002/72 (20130101) C01P 2002/88 (20130101) C01P 2004/03 (20130101) C01P 2006/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251288 | Johnson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeremiah A. Johnson (Boston, Massachusetts); Peyton Shieh (Cambridge, Massachusetts); Keith Husted (Boston, Massachusetts); Christopher M. Brown (Boston, Massachusetts); Samantha Lynn Kristufek (Lubbock, Texas) |
| ABSTRACT | The present disclosure provides compositions comprising: a) a copolymer prepared by a method comprising polymerizing in the presence of a metathesis catalyst: i) a first monomer, wherein each instance of the first monomer is independently of the formula: or salt thereof; ii) a second monomer, wherein each instance of the second monomer is independently of the formula: or a salt thereof; iii) optionally a third monomer, wherein the third monomer is different from the first monomer and the second monomer; and iv) optionally a reprocessing catalyst; and b) optionally the reprocessing catalyst; wherein the reprocessing catalyst is a Brønsted acid, Lewis acid, Brønsted base, Lewis base, or a salt thereof; provided that the composition comprises at least one of the reprocessing catalyst of iv) and the reprocessing catalyst of b). The compositions may be reprocessed (e.g., remolded) under elevated temperature and/or elevated pressure. |
| FILED | Tuesday, November 30, 2021 |
| APPL NO | 17/538098 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 61/02 (20130101) Original (OR) Class C08G 61/12 (20130101) C08G 2261/70 (20130101) C08G 2261/314 (20130101) C08G 2261/418 (20130101) C08G 2261/3222 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251300 | EPPS, III et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Thomas H. EPPS, III (Bear, Delaware); LaShanda T. J. Korley (Middletown, Delaware); Matthew D. Green (Phoenix, Arizona); Jignesh S. Mahajan (Newark, Delaware); Hoda Shokrollahzadeh Behbahani (Tempe, Arizona) |
| ASSIGNEE(S) | University of Delaware (Newark, Delaware); Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| INVENTOR(S) | Thomas H. EPPS, III (Bear, Delaware); LaShanda T. J. Korley (Middletown, Delaware); Matthew D. Green (Phoenix, Arizona); Jignesh S. Mahajan (Newark, Delaware); Hoda Shokrollahzadeh Behbahani (Tempe, Arizona) |
| ABSTRACT | Disclosed herein are bio-based polysulfones, and in particular, bisguaiacol-based PSfs synthesized from (i) at least one polymerizable lignin-based monomer having a structure corresponding to formula (I) wherein each R1 is independently either an H or a methyl group, wherein R2, R3, and R4 are each individually selected from an H or a methoxy group, and (ii) at least one polymerizable 4,4′-dihalophenyl sulfone as a comonomer. Also, disclosed herein are compositions comprising the bio-based polysulfones and a membrane comprising the composition |
| FILED | Thursday, June 11, 2020 |
| APPL NO | 17/616245 |
| CURRENT CPC | Separation B01D 61/025 (20130101) B01D 69/02 (20130101) B01D 71/68 (20130101) B01D 2315/08 (20130101) B01D 2325/02 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/441 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 75/20 (20130101) Original (OR) Class Compositions of Macromolecular Compounds C08L 81/06 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/1004 (20130101) H01M 8/1032 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251395 | Choudhury et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Fayetteville, Arkansas) |
| ASSIGNEE(S) | BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Fayetteville, Arkansas) |
| INVENTOR(S) | Dipankar Choudhury (Fayetteville, Arkansas); Min Zou (Fayetteville, Arkansas) |
| ABSTRACT | A composite comprising: substrate having thereon an intermediate layer and a diamond-like carbon (DLC) top layer on said intermediate layer, with increased adhesion strength to DLC and other hard coatings, and which provides a buffer layer for adjusting the uneven expansion/compression behavior of DLC coatings and substrates. |
| FILED | Monday, February 07, 2022 |
| APPL NO | 17/666517 |
| CURRENT CPC | Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/36 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 1/00 (20130101) C09D 5/002 (20130101) Original (OR) Class C09D 7/61 (20180101) C09D 7/67 (20180101) C09D 165/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251610 | Tu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Cincinnati (Cincinnati, Ohio) |
| ASSIGNEE(S) | University of Cincinnati (Cincinnati, Ohio) |
| INVENTOR(S) | Maobing Tu (Mason, Ohio); Yu Zhang (Cincinnati, Ohio); Yequan Sheng (Cincinnati, Ohio) |
| ABSTRACT | A method for pretreating lignocellulosic biomass to improve fermentability is disclosed. The method involves reacting lignocellulosic biomass with an acidic mixture while heating at a temperature from about 120° C. to about 200° C. to produce a prehydrolysate mixture. The acidic mixture includes a dilute acid and nucleophilic proteins, hydrolyzed amino acids or combinations thereof. |
| FILED | Thursday, February 10, 2022 |
| APPL NO | 17/668859 |
| CURRENT CPC | Fuels Not Otherwise Provided for; Natural Gas; Synthetic Natural Gas Obtained by Processes Not Covered by Subclasses C10G, C10K; Liquefied Petroleum Gas; Adding Materials to Fuels or Fires to Reduce Smoke or Undesirable Deposits or to Facilitate Soot Removal; Firelighters C10L 1/02 (20130101) C10L 2200/0469 (20130101) C10L 2290/26 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/10 (20130101) Original (OR) Class C12P 2201/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251613 | GONZALEZ et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ramon GONZALEZ (Tampa, Florida); James M. CLOMBURG (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ramon GONZALEZ (Tampa, Florida); James M. CLOMBURG (Tampa, Florida) |
| ABSTRACT | Methods of using microorganisms to make chemicals and fuels, including carboxylic acids, alcohols, hydrocarbons, and their alpha-, beta-, and omega-functionalized derivatives are described. Native or engineered thiolases are used condense a growing acyl-ACP and acetyl-ACP in combination with type II fatty acid synthesis. The resulting fatty acid biosynthesis cycle has an ATP yield analogous to the functional reverse β-oxidation cycle. |
| FILED | Tuesday, April 05, 2022 |
| APPL NO | 17/713480 |
| CURRENT CPC | Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/6409 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251648 | Mallette et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tracy L. Mallette (Albuquerque, New Mexico); Matthew R. Lakin (Albuquerque, New Mexico); Darko Stefanovic (Albuquerque, New Mexico) |
| ABSTRACT | A heterochiral strand displacement molecular circuit generally includes an input oligonucleotide, a first translator, a second translator, and an output oligonucleotide. The first translator generally includes a domain that binds to the input binding oligonucleotide, at least a portion of which is complementary to, and has the same chirality as, the input oligonucleotide. The first translator also includes a translation domain having chirality opposite the chirality of the input oligonucleotide (and the binding domain). The second translator generally includes a nucleotide sequence, at least a portion of which is complementary to, and has the same chirality as, the translation domain of the first translator. The output oligonucleotide includes a nucleotide sequence, at least a portion of which is complementary to, and has the same chirality as, the second translator. |
| FILED | Thursday, February 10, 2022 |
| APPL NO | 17/669007 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/44 (20130101) C12Q 1/6816 (20130101) C12Q 1/6876 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220252309 | Yu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| INVENTOR(S) | Nanfang Yu (Fort Lee, New Jersey); Jyotirmoy Mandal (New York, New York); Adam Overvig (New York, New York); Norman Nan Shi (San Jose, California); Meng Tian (Fort Lee, New Jersey) |
| ABSTRACT | Systems and methods for radiative cooling and heating are provided. For example, systems for radiative cooling can include a top layer including one or more polymers, where the top layer has high emissivity in at least a portion of the thermal spectrum and an electromagnetic extinction coefficient of approximately zero, absorptivity of approximately zero, and high transmittance in at least a portion of the solar spectrum, and further include a reflective layer including one or more metals, where the reflective layer has high reflectivity in at least a portion of the solar spectrum. |
| FILED | Monday, March 21, 2022 |
| APPL NO | 17/699789 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 27/18 (20130101) B32B 27/283 (20130101) B32B 33/00 (20130101) Solar Heat Collectors; Solar Heat Systems F24S 10/40 (20180501) F24S 70/30 (20180501) F24S 70/60 (20180501) F24S 70/225 (20180501) Refrigeration Machines, Plants or Systems; Combined Heating and Refrigeration Systems; Heat-pump Systems F25B 23/003 (20130101) Original (OR) Class Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 2245/06 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/44 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220252958 | Fejer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin M. Fejer (Emerald Hills, California); Carsten Langrock (Santa Clara, California); Marc P. Jankowski (Palo Alto, California) |
| ABSTRACT | Improved efficiency for nonlinear optical interactions is provided by using strongly confining waveguides for simultaneous imposition of dispersion design constraints at two or more dispersion orders. Quasi-phase-matching allows for phase-matching to be accomplished independently of the waveguide design, which helps provide sufficient design freedom for the dispersion design. |
| FILED | Friday, March 12, 2021 |
| APPL NO | 17/200422 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/392 (20210101) G02F 1/395 (20130101) G02F 1/3528 (20210101) G02F 1/3548 (20210101) Original (OR) Class G02F 1/3775 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220253076 | Cleland-Huang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Notre Dame du Lac (South Bend, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jane Cleland-Huang (South Bend, Indiana); Michael Vierhauser (South Bend, Indiana); Ankit Agrawal (South Bend, Indiana) |
| ABSTRACT | A method for configuring a multiple autonomous drone mission includes displaying, a plurality of queries on a display of the computing device. The method further includes receiving, via a user interface, a plurality of inputs responsive to the plurality of queries. At least a first input of the plurality of inputs specifies a type of mission to be performed and at least a second input of the plurality of inputs specifies a geographical area in which a mission to be performed will be carried out. The method further includes automatically determining, based on the plurality of inputs, an initial location to move to for each of a plurality of drones available for implementing the mission. The method further includes automatically determining, based on the plurality of inputs, a series of tasks for each of the plurality of drones. |
| FILED | Friday, January 07, 2022 |
| APPL NO | 17/571449 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 39/024 (20130101) B64C 2201/126 (20130101) B64C 2201/127 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/104 (20130101) Original (OR) Class Wireless Communication Networks H04W 4/029 (20180201) H04W 4/30 (20180201) H04W 4/90 (20180201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220253426 | Zhu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | International Business Machines Corporation (Armonk, New York); The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yada Zhu (Irvington, New York); Jinjun Xiong (Goldens Bridge, New York); Jingrui He (Champaign, Illinois); Lecheng Zheng (Savoy, Illinois); Xiaodong Cui (Chappaqua, New York) |
| ABSTRACT | Time series data can be received. A machine learning model can be trained using the time series data. A contaminating process can be estimated based on the time series data, the contaminating process including outliers associated with the time series data. A parameter associated with the contaminating process can be determined. Based on the trained machine learning model and the parameter associated with the contaminating process, a single-valued metric can be determined, which represents an impact of the contaminating process on the machine learning model's future prediction. A plurality of different outlier detecting machine learning models can be used to estimate the contaminating process and the single-valued metric can be determined for each of the plurality of different outlier detecting machine learning models. The plurality of different outlier detecting machine learning models can be ranked according to the associated single-valued metric. |
| FILED | Monday, February 08, 2021 |
| APPL NO | 17/170164 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/2365 (20190101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220254147 | MALIK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | JITENDRA MALIK (BERKELEY, California); PRATIK MUKHERJEE (SAN FRANCISCO, California); ESTHER L. YUH (SAN FRANCISCO, California); WEI-CHENG KUO (UNION CITY, California); CHRISTIAN HAENE (BERKELEY, California) |
| ABSTRACT | A computer-implemented method can include a training phase and a hemorrhage detection phase. The training phase can include: receiving a first plurality of frames from at least one original computed tomography (CT) scan of a target subject, wherein each frame may or may not include a visual indication of a hemorrhage, and further wherein each frame including a visual indication of a hemorrhage has at least one label associated therewith; and using a fully convolutional neural network (FCN) to train a model by determining, for each of the first plurality of frames, whether at least one sub-portion of the frame includes a visual indication of a hemorrhage and classifying the sub-portion of the frame based on the determining. The hemorrhage detection phase can include: receiving a second plurality of frames from a CT scan of a target subject, wherein each frame may or may not include a visual indication of a hemorrhage; and determining, for each of the second plurality of frames, whether a plurality of sub-portions of the frame includes a visual indication of a hemorrhage based at least in part on the trained model. |
| FILED | Monday, July 20, 2020 |
| APPL NO | 17/597714 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/10081 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30016 (20130101) Image or Video Recognition or Understanding G06V 10/82 (20220101) G06V 10/764 (20220101) G06V 10/774 (20220101) Original (OR) Class G06V 2201/031 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220254508 | Sy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SIPPA Solutions, LLC (Bayside, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bon K. Sy (Bayside, New York); Jin Chen (Bayside, New York) |
| ABSTRACT | A method for identifying a manifold cluster using statistically significant association patterns. A data set of real, continuous numbers is received and converted to corresponding discrete data representations. Statistically significant association patterns of the data are utilized to generate a manifold cluster. Customized actions, such as customized messages, are generated that are specific to the manifold cluster. |
| FILED | Thursday, April 14, 2022 |
| APPL NO | 17/720537 |
| CURRENT CPC | Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/70 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220254620 | Cooks et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Graham Cooks (West Lafayette, Indiana); Dalton Snyder (West Lafayette, Indiana); Christopher Pulliam (West Lafayette, Indiana) |
| ABSTRACT | The invention generally relates to systems and methods for precursor and neutral loss scan in an ion trap. In certain aspects, the invention provides a system that includes a mass spectrometer having an ion trap, and a central processing unit (CPU). The CPU includes storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to excite a precursor ion and eject a product ion in the single ion trap. |
| FILED | Wednesday, April 27, 2022 |
| APPL NO | 17/730830 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 49/0081 (20130101) Original (OR) Class H01J 49/424 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220255001 | Gopalan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Padma Gopalan (Madison, Wisconsin); Jonathan H. Dwyer (Madison, Wisconsin); Katherine Jinkins (Evanston, Illinois); Michael Scott Arnold (Middleton, Wisconsin) |
| ABSTRACT | Methods for forming films of aligned carbon nanotubes are provided. Also provided are the films formed by the methods and electronic devices that incorporate the films as active layers. The films are formed by flowing a suspension of carbon nanotubes over a substrate surface that is chemically and topographically patterned. The methods provide a rapid and scalable means of forming films of densely packed and aligned carbon nanotubes over large surface areas. |
| FILED | Thursday, February 03, 2022 |
| APPL NO | 17/591711 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0003 (20130101) Original (OR) Class H01L 51/0048 (20130101) H01L 51/0558 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220255106 | NUCKOLLS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| INVENTOR(S) | Colin NUCKOLLS (New York, New York); Raul HERNANDEZ SANCHEZ (New York, New York); Yuan YANG (New York, New York); Thomas SISTO (New York, New York); Margarita MILTON (New York, New York) |
| ABSTRACT | The present disclosure relates to organic electrolyte solutions including organic electrolytes (e.g., aromatic imides, ferrocenes, spiro fused compounds, or cyclopropenium compounds), and redox flow batteries and systems including the same. |
| FILED | Wednesday, February 16, 2022 |
| APPL NO | 17/673679 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/20 (20130101) Original (OR) Class H01M 8/2435 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220255137 | Stoddart et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois); King Abdulaziz City for Science and Technology (KACST} (Riyadh, Saudi Arabia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Fraser Stoddart (Evanston, Illinois); Mirkin A. Chad (Wilmetie, Illinois); Woo Nam Kwan (Evanston, Illinois); Park S. Sarah (Evanston, Illinois) |
| ABSTRACT | Disclosed herein are batteries comprising a M3(C6(C6H2X2)3)2 active material, wherein M is a late transition metal and X is selected from O, S, or NH, and an aqueous electrolyte comprising a multivalent cationic charge carrier. Also disclosed are methods of making the same. |
| FILED | Friday, July 10, 2020 |
| APPL NO | 17/597507 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/42 (20130101) H01M 4/0404 (20130101) H01M 4/5815 (20130101) H01M 4/5825 (20130101) H01M 10/38 (20130101) Original (OR) Class H01M 2004/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220255506 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenle Chen (Oviedo, Florida); Yuchen Cao (Orlando, Florida); Haifeng Lyu (Orlando, Florida) |
| ABSTRACT | Described herein is a reconfigurable asymmetrical load-modulated balanced amplifier. The reconfigurable asymmetrical load-modulated balanced amplifier can include a radio frequency (RF) input port, an RF output port, a peaking amplifier circuit operably coupled between the RF input and RF output ports, where the peaking amplifier circuit is a balanced amplifier that comprises a pair of asymmetrical power amplifiers, and a carrier amplifier circuit operably coupled to the RF input port. |
| FILED | Wednesday, December 08, 2021 |
| APPL NO | 17/545164 |
| CURRENT CPC | Amplifiers H03F 1/42 (20130101) H03F 1/0288 (20130101) Original (OR) Class H03F 3/245 (20130101) H03F 2200/451 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220255507 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenle Chen (Oviedo, Florida); Yuchen Cao (Orlando, Florida) |
| ABSTRACT | Described herein are load-modulated balanced amplifiers. An example load-modulated balanced amplifier can include a radio frequency (RF) input port, a RF output port, a peaking amplifier circuit operably coupled between the RF input and RF output ports, where the peaking amplifier circuit is a balanced amplifier that includes a pair of power amplifiers, and a carrier amplifier circuit operably coupled to the RF input port. |
| FILED | Wednesday, December 08, 2021 |
| APPL NO | 17/545166 |
| CURRENT CPC | Amplifiers H03F 1/56 (20130101) H03F 1/0288 (20130101) Original (OR) Class H03F 3/195 (20130101) H03F 3/245 (20130101) H03F 3/602 (20130101) H03F 2200/451 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220255587 | Dunna et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Manideep Dunna (La Jolla, California); Miao Meng (La Jolla, California); Patrick P. Mercier (La Jolla, California); Dinesh Bharadia (La Jolla, California) |
| ABSTRACT | termination circuits for backscatter communication in an integrated wake-up receiver tag device. A reflective termination circuit includes a first branch having an open load and a shorted load with first branch offset reflection coefficients and with a connection to an antenna. A second branch has a capacitive load and an inductive load with second branch offset reflection coefficients and with a connection to an antenna. A MIMO termination circuit includes plurality of transmission lines each providing a unique delay that is offset compared to other ones of the plurality of transmission lines. Switched connections to a corresponding array of antennas introduce a delay between a received and backscattered signal at each antenna in the array of antennas. |
| FILED | Monday, February 07, 2022 |
| APPL NO | 17/666198 |
| CURRENT CPC | Transmission H04B 5/0031 (20130101) H04B 5/0037 (20130101) H04B 5/0062 (20130101) Original (OR) Class H04B 7/0413 (20130101) Wireless Communication Networks H04W 52/0203 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220255775 | D'Oro et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Salvatore D'Oro (Allston, Massachusetts); Tommaso Melodia (Newton, Massachusetts); Francesco Restuccia (Boston, Massachusetts) |
| ABSTRACT | A machine learning (ML) agent operates at a transmitter to optimize signals transmitted across a communications channel. A physical signal modifier modifies a physical layer signal prior to transmission as a function of a set of signal modification parameters to produce a modified physical layer signal. The ML agent parses a feedback signal from a receiver across the communications channel, and determines a present tuning status as a function of the signal modification parameters and the feedback signal. The ML agent generates subsequent signal modification parameters based on the present tuning status and a set of stored tuning statuses, thereby updating the physical signal modifier to generate a subsequent modified physical layer signal to be transmitted across the communications channel. |
| FILED | Friday, February 11, 2022 |
| APPL NO | 17/650686 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 1/0073 (20130101) H04L 5/0055 (20130101) H04L 25/0254 (20130101) Original (OR) Class H04L 25/03006 (20130101) H04L 2025/03464 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220256711 | Xiao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jianliang Xiao (Louisville, Colorado); Yan Sun (Boulder, Colorado); Wei Ren (Boulder, Colorado) |
| ABSTRACT | Soft motherboards having rigid plugin modules are described herein. In one aspect of the present disclosure, an electronic device can include a polymeric substrate having: a plurality of slots, each configured for receiving an electronic module; one or more electrical junctions including a stretchable conductive interconnect electronically coupling a slot to another slot of the plurality of slots; and at least one electronic module including: a film configured to: support other components of the electronic module; and be inserted, and be partially housed in, one of the plurality of slots of the polymeric substrate; and at least one electrode coupled to the film and positioned to be in contact with a corresponding electrical junction of the polymeric substrate when the film is partially housed in the polymeric substrate. |
| FILED | Thursday, February 10, 2022 |
| APPL NO | 17/668799 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 25/04 (20130101) H01L 35/32 (20130101) H01L 35/34 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/09 (20130101) H05K 1/189 (20130101) Original (OR) Class H05K 1/0283 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20220250029 | Rezaei et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Curators of the University of Missouri (Columbia, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fateme Rezaei (Rolla, Missouri); Harshul V. Thakkar (Rolla, Missouri) |
| ABSTRACT | Carbon dioxide (CO2) capture materials comprising one or more 3D-printed zeolite monoliths for the capture and or removal of CO2 from air or gases in enclosed compartments, including gases or mixtures of gases having less than about 5% CO2. Methods for preparing 3D-printed zeolite monoliths useful as CO2 capture materials and filters, as well as methods of removing CO2 from a gas or mixture of gases in an enclosed compartment using 3D-printed zeolite monoliths are provided. |
| FILED | Tuesday, March 08, 2022 |
| APPL NO | 17/689344 |
| CURRENT CPC | Separation B01D 53/02 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/12 (20130101) B01J 20/165 (20130101) Original (OR) Class B01J 20/2803 (20130101) B01J 20/28071 (20130101) B01J 2220/82 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220253727 | Watson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Oregon State University (Corvallis, Oregon) |
| ASSIGNEE(S) | Oregon State Univeristy (Corvallis, Oregon) |
| INVENTOR(S) | James R. Watson (Corvallis, Oregon); Andrew John Woodill (Corvallis, Oregon); Maria Kavanaugh (Corvallis, Oregon) |
| ABSTRACT | A general-purpose approach to solving the core problems of detecting and predicting the actions of invisible actors, and the consequential challenges of intervention and prevention. The operational forecasting system is applied to data gathered from complex systems. The operational forecasting system uses novel early-warning signals that are based on anomalous behaviors of actors/agents that are observed, as they respond to those unobserved actors that are the source of systemic change. The operational forecasting system targets predicting when an event will occur, before it does, based on the anomalous behaviors of observed actors responding to those invisible actors that are creating the perturbation (i.e. the murmuration). |
| FILED | Tuesday, May 18, 2021 |
| APPL NO | 17/323823 |
| CURRENT CPC | Electric Digital Data Processing G06F 17/18 (20130101) Computer Systems Based on Specific Computational Models G06N 5/04 (20130101) Original (OR) Class G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220254575 | Brambilla et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | FastCAP Systems Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicolò Michele Brambilla (Boston, Massachusetts); Fabrizio Martini (Boston, Massachusetts) |
| ABSTRACT | A solid state polymer electrolyte is disclosed for use in an ultracapacitor. The electrolyte includes an ionic liquid and a polymer and may include other additives, wherein an ultracapacitor that utilizes the solid state electrolyte is configured to output electrical energy at temperatures between about −40° C. and about 250° C. or more. |
| FILED | Friday, September 17, 2021 |
| APPL NO | 17/478182 |
| CURRENT CPC | Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 9/15 (20130101) H01G 9/028 (20130101) H01G 11/04 (20130101) Original (OR) Class H01G 11/56 (20130101) H01G 11/62 (20130101) H01G 11/64 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/13 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220254576 | Brambilla et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | FastCAP Systems Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicolò Michele Brambilla (Boston, Massachusetts); Fabrizio Martini (Boston, Massachusetts) |
| ABSTRACT | A solid state polymer electrolyte is disclosed for use in an ultracapacitor. The electrolyte includes an ionic liquid and a polymer and may include other additives, wherein an ultracapacitor that utilizes the solid state electrolyte is configured to output electrical energy at temperatures between about −40° C. and about 250° C. or more. |
| FILED | Friday, April 29, 2022 |
| APPL NO | 17/732993 |
| CURRENT CPC | Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 9/15 (20130101) H01G 9/028 (20130101) H01G 11/04 (20130101) Original (OR) Class H01G 11/56 (20130101) H01G 11/62 (20130101) H01G 11/64 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/13 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220254620 | Cooks et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Graham Cooks (West Lafayette, Indiana); Dalton Snyder (West Lafayette, Indiana); Christopher Pulliam (West Lafayette, Indiana) |
| ABSTRACT | The invention generally relates to systems and methods for precursor and neutral loss scan in an ion trap. In certain aspects, the invention provides a system that includes a mass spectrometer having an ion trap, and a central processing unit (CPU). The CPU includes storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to excite a precursor ion and eject a product ion in the single ion trap. |
| FILED | Wednesday, April 27, 2022 |
| APPL NO | 17/730830 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 49/0081 (20130101) Original (OR) Class H01J 49/424 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220255078 | Komatsu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Nissan North America, Inc. (Franklin, Tennessee); United States of America as Represented by the Administrator of NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hideyuki Komatsu (Yokosuka, Japan); Shigemasa Kuwata (Palo Alto, California); Atsushi Ohma (Kanagawa, Japan); Maarten Sierhuis (San Francisco, California); Xin Yang (Palo Alto, California); Najamuddin Mirza Baig (San Jose, California); Balachandran Gadaguntla Radhakrishnan (San Mateo, California); Shreyas Honrao (Sunnyvale, California); John Lawson (San Francisco, California); Mohit Rakesh Mehta (Santa Clara, California) |
| ABSTRACT | An all-solid-state battery comprises a lithium anode, a cathode, solid electrolyte and a protective layer between the solid electrolyte and the lithium anode. The protective layer comprises an ion-conducting material having an electrochemical stability window against lithium of at least 1.0 V, a lowest electrochemical stability being 0.0 V and a highest electrochemical stability being greater than 1.0 V. More particularly, when the solid electrolyte is LiSiCON, the electrochemical stability window is at least 1.5 V, the lowest electrochemical stability is 0.0 V and the highest electrochemical stability is greater than 1.5 V. When the solid electrolyte is sulfide-based, the electrochemical stability window is at least 2.0 V, the lowest electrochemical stability is 0.0 V and the highest electrochemical stability is greater than 2.0 V. |
| FILED | Monday, February 08, 2021 |
| APPL NO | 17/169962 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/382 (20130101) H01M 4/485 (20130101) H01M 4/582 (20130101) Original (OR) Class H01M 10/0525 (20130101) H01M 10/0562 (20130101) H01M 2004/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220255119 | Kuwata et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Nissan North America, Inc. (Franklin, Tennessee); United States of America as Represented by the Administrator of NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shigemasa Kuwata (Palo Alto, California); Hideyuki Komatsu (Yokosuka, Japan); Maarten Sierhuis (San Francisco, California); Balachandran Gadaguntla Radhakrishnan (San Mateo, California); Shreyas Honrao (Sunnyvale, California); John Lawson (San Francisco, California) |
| ABSTRACT | A lithium battery comprises cathode active material comprising particles of a transition metal oxide, each particle coated in an ion-conducting material that has an electrochemical stability window against lithium of at least 2.2 V, a lowest electrochemical stability being less than 2.0 V and a highest electrochemical stability being greater than 4.2 V, the ion-conducting material selected from the group consisting of: Cs2LiC13; Cs2LiCrF6; Cs2LiDyCl6; Cs2LiErCl6; Cs2LiGdCl6; Cs2LiLuCl6; Cs2LiNdCl6; Cs2LiPrCl6; Cs2LiScCl6; Cs2LiSmCl6; Cs2LiTbCl6; Cs2LiTmCl6; Cs2LiYCl6; Cs3Li2Cl5; Cs3LiCl4; CsLi2Cl3; CsLi3Cl4; CsLiBeF4; CsLiCl2; K10LiZr6H4O2F35; K2LiCeCl6; K2LiDyCl6; K2LiGdCl6; K2LiLaCl6; K2LiPrCl6; K2LiTbCl6; KLiDyF5; KLiErF5; KLiGdF5; KLiHoF5; KLiLuF5; KLiPH2O4F; KLiTbF5; KLiTmF5; KLiYF5; Li10Mg7Cl24; Li2B3O4F3; Li2B6O9F2; Li2BeCl4; Li2BF5; Li2CaHfF8; Li2MgCl4; Li2SiF6; Li2Ta2(OF2)3; Li2ZnCl4; Li2ZrF6; Li3AlF6; Li3ErCl6; Li3ScCl6; Li3ScF6; Li3ThF7; Li3YF6; Li4Be3P3BrO12; Li4Be3P3ClO12; Li4ZrF8; Li6ZrBeF12; Li9Mg3P4O16F3; LiAlCl4; LiB6O9F; LiBF4; LiGdCl4; LiLuF4; LiScF4; LiTaF6; LiThF5; LiYF4; LiZr5T1F22; Na3Li3Al2F12; NaLi2AlF6; NaLiBeF4; NaLiMgPO4F; Rb2LiCeCl6; Rb2LiDyCl6; Rb2LiErCl6; Rb2LiGdCl6; Rb2LiLaCl6; Rb2LiLuCl6; Rb2LiPrCl6; Rb2LiScCl6; Rb2LiTbCl6; Rb2LiYCl6; RbLi2Be2F7; RbLiCl2; and RbLiF2. |
| FILED | Monday, February 08, 2021 |
| APPL NO | 17/170040 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/366 (20130101) H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 4/582 (20130101) H01M 10/0525 (20130101) Original (OR) Class H01M 10/0562 (20130101) H01M 2300/0065 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20220248672 | KLESSIG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BOYCE THOMPSON INSTITUTE FOR PLANT RESEARCH, INC. (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel KLESSIG (Dryden, New York); Murli MANOHAR (Ithaca, New York); Frank SCHROEDER (Ithaca, New York) |
| ABSTRACT | Compositions and methods for modulating a microbiome are disclosed. In accordance with the instant invention, methods of modifying and/or modulating a microbiome (e.g., the composition of a microbiome) are provided. The methods of the instant invention comprise contacting the microbiome (e.g., the assemblage of organisms composing the microbiome) with a compound excreted by an organism (e.g., nematode), particularly an organism that naturally lives in or is part of the microbiome. |
| FILED | Wednesday, July 08, 2020 |
| APPL NO | 17/621938 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 43/16 (20130101) Original (OR) Class Biocidal, Pest Repellant, Pest Attractant or Plant Growth Regulatory Activity of Chemical Compounds or Preparations A01P 1/00 (20210801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220248726 | MCHUGH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia); POP OATS LLC (ALBANY, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | TARA H. MCHUGH (ALBANY, California); ZHONGLI PAN (EL MACERO, California); DONALD A. OLSON (ISLETON, California); MARC PFEIFFER (LOS ANGELES, California); RODGER MORRIS (OAKLAND, California) |
| ABSTRACT | A crisp and hard whole kernel oat snack product made by fully hydrating whole oat kernels (i.e. oat groats), and then gelatinizing the starch in the whole oat kernels using an infrared process. The gelatinized oats are then roasted in a hot air dryer. The resulting food product is measurably harder and crisper than other whole oat products currently available. |
| FILED | Monday, April 25, 2022 |
| APPL NO | 17/727908 |
| CURRENT CPC | Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 7/148 (20160801) Original (OR) Class A23L 7/1975 (20160801) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251589 | MA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jianxin MA (West Lafayette, Indiana); Bo REN (Beijing, China PRC); Jingbo DUAN (West Lafayette, Indiana); Xutong WANG (West Lafayete, Indiana) |
| ABSTRACT | Rhizobial infection is the key process for initiating symbiotic nitrogen-fixing root nodules in legumes, which requires specific recognition of signal molecules produced by the bacteria and their hosts. Here, it is established that rhizobial tRNA-derived small RNA fragments (tRFs) are crucial signal molecules modulating host nodulation, which uncovers a bacterial small RNA-mediated mechanism for prokaryote-eukaryote interaction. Transgenic plants are also provided that express a construct encoding rhizobial-derived tRNA, which is subsequently cleaved to produce artificial tRFs. Constructs and methods of producing the same are also provided, as well as modifications for repressing a mechanism for the negative regulation of nodulation present within plants. |
| FILED | Monday, May 18, 2020 |
| APPL NO | 17/611802 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8218 (20130101) C12N 15/8262 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251640 | AIDEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); BAYLOR COLLEGE OF MEDICINE (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Erez AIDEN (Houston, Texas); Elena STAMENOVA (Cambridge, Massachusetts); Andreas GNIRKE (Cambridge, Massachusetts); Eric S. LANDER (Cambridge, Massachusetts); Neva DURAND (Houston, Texas); Olga DUDCHENKO (Houston, Texas) |
| ABSTRACT | Methods for analyzing spatial proximity and epigenetic profile of nucleic acids in cells, the method comprising: fragmenting the nucleic acids, the fragmented nucleic acids comprising overhanging ends; filling in the overhanding ends with one or more labeled nucleotides; joining the filled in ends to create one or more end-joined nucleic acid fragments with one or more junctions; treating the end-joined nucleic acid fragments with bisulfite; isolating the bisulfite-treated end-joined nucleic acid fragments using the label; and determining sequence at the one or more junctions in the bisulfite treated end-joined nucleic acid fragments, thereby determining spatial proximity between the nucleic acids and the methylation profile of the nucleic acids. |
| FILED | Monday, May 18, 2020 |
| APPL NO | 17/612160 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6869 (20130101) Original (OR) Class C12Q 2600/154 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20220250712 | Cooper et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Goverment as represented by the Department of Veterans Affairs (Washington, District of Columbia); University of Pittsburgh - Of The Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rory A. Cooper (Gibsonia, Pennsylvania); Benjamin Gebrosky (Gibsonia, Pennsylvania) |
| ABSTRACT | Hand pedals for turning the crank set of an arm driven tricycle have modular interchangeable components including a bearing which mounts on the spindle of the crank. A bridge connects the bearing to a handle. The bridge has two legs connected by a transverse spar. Different bridges and handles may be used having different sizes, shapes, lengths and angular orientations which allow the hand pedals to be customized to accommodate a particular user. Hand pedals may also be used on hand cranked bicycles, stationary hand cranked bicycles and industrial equipment. |
| FILED | Tuesday, May 12, 2020 |
| APPL NO | 17/610459 |
| CURRENT CPC | Rider Propulsion of Wheeled Vehicles or Sledges; Powered Propulsion of Sledges or Cycles; Transmissions Specially Adapted for Such Vehicles B62M 3/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251162 | Pisegna et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); The United States Government Represented by The Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California); The United States Government Represented by The Department Of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | Joseph R. Pisegna (Santa Monica, California); Patrizia M. Germano (Santa Monica, California); John P. Vu (Los Angeles, California) |
| ABSTRACT | In certain embodiments novel PAC1 receptor agonists are provided wherein the agonists comprise a targeting sequence that binds to the PAC1 receptor and said targeting sequence is attached to an amino acid sequence comprising a fragment of the maxadilan amino acid sequence, wherein the targeting sequence comprises a full-length 38 amino acid PACAP peptide or an N-terminus fragment thereof containing the amino acid sequence HSDGIF, wherein said targeting sequence optionally comprises an amino acid insertion between residues 11 and 12 of said PACAP peptide or fragment thereof; and the fragment of the maxadilan amino acid sequence comprises a fragment of the maxadilan sequence effective to activate PAC1 signaling. |
| FILED | Monday, October 25, 2021 |
| APPL NO | 17/510090 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4985 (20130101) A61K 38/00 (20130101) A61K 38/2278 (20130101) A61K 47/60 (20170801) A61K 47/61 (20170801) A61K 47/65 (20170801) Peptides C07K 14/43577 (20130101) C07K 14/57563 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220251647 | Tsalik et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duke University (Durham, North Carolina); United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ephraim L. Tsalik (Cary, North Carolina); Geoffrey S. Ginsburg (Durham, North Carolina); Christopher W. Woods (Durham, North Carolina); Ricardo Henao Giraldo (Durham, North Carolina); Rachel A. Myers (Raleigh, North Carolina) |
| ABSTRACT | The present disclosure provides methods for determining whether a subject has sepsis, or is at risk of developing sepsis, and methods of treating the subject based on the determination. Also provided are methods for determining an increased risk of mortality in a subject with sepsis or suspected of having sepsis, and methods of treating the subject based on the determination. Systems useful for the same are also provided. |
| FILED | Friday, February 18, 2022 |
| APPL NO | 17/651579 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6876 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20220252742 | Kanatzidis et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mercouri G. Kanatzidis (Wilmette, Illinois); Yihui He (Evanston, Illinois) |
| ABSTRACT | Methods and devices for detecting incident radiation, such as incident X-rays or gamma-rays, are provided. The methods and devices use single-crystalline mercury chalcoiodide compounds having the formula Hg3Q2I2, where Q represents a chalcogen atom or a combination of chalcogen atoms, as photoelectric materials. Also provided are methods for growing single-crystals of the mercury chalcoiodide compounds using external organic chemical transport agents. |
| FILED | Friday, April 15, 2022 |
| APPL NO | 17/721634 |
| CURRENT CPC | Measurement of Nuclear or X-radiation G01T 1/24 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/18 (20130101) H01L 31/032 (20130101) H01L 31/085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220254944 | Kanatzidis et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mercouri G. Kanatzidis (Wilmette, Illinois); Yihui He (Evanston, Illinois) |
| ABSTRACT | Methods and devices for detecting incident radiation are provided. The methods and devices use high quality single-crystals of photoactive semiconductor compounds in combination with metal anodes and metal cathodes that provide for enhanced photodetector performance. |
| FILED | Wednesday, November 10, 2021 |
| APPL NO | 17/523141 |
| CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 11/003 (20130101) C30B 29/12 (20130101) Measurement of Nuclear or X-radiation G01T 1/24 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/032 (20130101) H01L 31/085 (20130101) Original (OR) Class H01L 31/0224 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Classified Government Agency
| US 20220256743 | Pelletier et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BAE SYSTEMS Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| ASSIGNEE(S) | BAE SYSTEMS Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| INVENTOR(S) | Gerard J. Pelletier (Amherst, New Hampshire); David E. Thompson (Nashua, New Hampshire) |
| ABSTRACT | The system and method for cooling a card cage using a compact combination vacuum/dip brazed card cage with integral liquid cooling passages, wherein all surfaces of the card cage are used for cooling. The card cage cooling 3U circuit cards internally and non-standard boards mounted externally by heat sinking the non-standard boards to the external walls. Finned, internal liquid cooling passages being orificed to maintain a total pressure drop from a single system inlet to a single system outlet of no more than 5 psi. |
| FILED | Wednesday, February 10, 2021 |
| APPL NO | 17/172143 |
| CURRENT CPC | Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 7/20281 (20130101) H05K 7/20636 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20220252546 | Woods et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States of America, as represented by the Secretary of Commerce (Gathersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Solomon Isaac Woods (Kensington, Maryland); Thinh Quoc Bui (Kensington, Maryland); Weston Leo Tew, JR. (Gaithersburg, Maryland) |
| ABSTRACT | Embodiments of the present invention relate to a system and method for performing temperature-dependent measurements of a magnetic nanoparticle sample. The system includes high frequency coils and sample temperature tunable assembly to determine the specific relaxation process for magnetic nanoparticle sample using both time and frequency domain techniques. During the temperature-dependent measurements of a magnetic nanoparticle sample, system in accordance with embodiments of the present invention resolve the nanoparticle dynamics using a temperature-tunable dual mode, AC susceptibility and magnetic relaxometry, to cover a broad range of frequencies and time scales. Other operational modes of the invention can drive the nanoparticles with arbitrary waveforms (sinusoidal, sum of sinusoids, or repeated pulses) to elicit and measure tailored response behavior from the magnetic nanoparticle sample. |
| FILED | Friday, February 11, 2022 |
| APPL NO | 17/669992 |
| CURRENT CPC | Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 1/026 (20130101) G01K 7/16 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/72 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Environmental Protection Agency (EPA)
| US 20220250943 | LYTLE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | U.S. Environmental Protection Agency (Washington, District of Columbia) |
| ASSIGNEE(S) | U.S. Environmental Protection Agency (Washington, District of Columbia) |
| INVENTOR(S) | Darren A LYTLE (Liberty, Ohio); Mallikarjuna N. Nadagouda (Mason, Ohio) |
| ABSTRACT | A method and apparatus for treating residuals or waste streams from a plant, such as a drinking water treatment plant. The method includes the steps of obtaining plant residuals or waste streams from a water treatment plant and irradiating the plant residuals or waste streams using microwave radiation from a microwave source. The method also includes the step of drying the plant residuals or waste streams to a predetermined moisture, volume, or weight content reduction and disposing of the same. |
| FILED | Thursday, April 28, 2022 |
| APPL NO | 17/731341 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/302 (20130101) Original (OR) Class C02F 11/131 (20190101) Electric Heating; Electric Lighting Not Otherwise Provided for H05B 6/804 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Smithsonian Institution (SI)
| US 20220252489 | MILLER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Smithsonian Institution (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander Whitman MILLER (Annapolis, Maryland); Amanda C. REYNOLDS (Annapolis, Maryland) |
| ABSTRACT | The current disclosure provides a gas-liquid falling film equilibration apparatus, systems incorporating the apparatus, and methods of their use. The apparatus comprises a chamber, an equilibration member within the chamber, liquid and gas inlet and outlets, such that a liquid introduced into the chamber from the liquid inlet contacts the upper portion of the outer surface of the equilibration member. The apparatus finds use in the measurement of dissolved gases in a variety of liquids including the measurement of carbon dioxide in water. |
| FILED | Wednesday, February 23, 2022 |
| APPL NO | 17/678556 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/38 (20130101) Original (OR) Class G01N 33/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20220251062 | Striker et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Todd Striker (Madison, Wisconsin); Nathan Joseph Wlodarchak (Madison, Wisconsin); John Bruce Feltenberger (Madison, Wisconsin); Jennifer Golden (Waunakee, Wisconsin) |
| ABSTRACT | Biochemically active PASTA kinase inhibitors which exploit subtle structural differences between human kinases and bacterial PASTA kinases to improve specificity and inhibitor activity. The disclosed kinase inhibitors have the general formula: wherein: R1=Me, Et, n-Pr, —CH2CH2OH, —CH2CH2OP(O)(OH)2, —CH2CH2NMe2; R2=H, Me, Et, o-Pr, i-Pr, CF3, Cl, OMe; R3=H, Me, NHMe, NHBn, Cl, NO2, OMe, F, CN; and Ar= |
| FILED | Wednesday, February 10, 2021 |
| APPL NO | 17/172314 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/496 (20130101) A61K 31/506 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/06 (20180101) Heterocyclic Compounds C07D 239/42 (20130101) C07D 277/28 (20130101) C07D 401/04 (20130101) Original (OR) Class C07D 417/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220252013 | Beinor et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Technologies Corporation (Farmington, Connecticut) |
| ASSIGNEE(S) | Raytheon Technologies Corporation (Farmington, Connecticut) |
| INVENTOR(S) | Michael A. Beinor (Vernon, Connecticut); Timothy J. Castaldo (Wethersfield, Connecticut); Christopher M. Valva (Manchester, Connecticut); Nasr A. Shuaib (Watertown, Massachusetts); Mitchell D. Panton (West Hartford, Connecticut) |
| ABSTRACT | A turbomachine has a bearing in a bearing compartment. A first seal system isolates the bearing compartment and has: a first runner; a second runner; an inner seal encircling the first runner; and an outer seal encircling the second runner. The inner seal has a static clearance with the first runner. The outer seal has a static clearance with the second runner, greater than the inner seal static clearance. The first runner has an inner portion cantilevered inward. The second runner has an outer portion cantilevered outward. |
| FILED | Friday, February 05, 2021 |
| APPL NO | 17/168768 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 25/183 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/06 (20130101) F02C 7/28 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/323 (20130101) F05D 2240/55 (20130101) F05D 2260/98 (20130101) F05D 2260/232 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220252197 | Zilic |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell International Inc. (Charlotte, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kyle Thomas Zilic (Minneapolis, Minnesota) |
| ABSTRACT | Apparatuses, devices, systems, and methods are described that provide fluid flow connectors. An example fluid flow connector includes a first connector body that defines a first inner bore and a first plurality of outer bores. The example connector further includes a second connector body that defines a second inner bore and a second plurality of outer bores. In an operational configuration in which the first connector body is attached to the second connector body, the first inner bore mates with the second inner bore to form a first fluid channel, and each of the first plurality of outer bores mate with a respective one of the second plurality of outer bores to form a second fluid channel. The example connector further includes a sealing mechanism that, in the operational configuration, seals the first fluid channel from the second fluid channel and seal the second fluid channel from an external environment of the fluid flow connector. |
| FILED | Friday, February 05, 2021 |
| APPL NO | 17/248748 |
| CURRENT CPC | Pipes; Joints or Fittings for Pipes; Supports for Pipes, Cables or Protective Tubing; Means for Thermal Insulation in General F16L 39/005 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, August 11, 2022.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20220811.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page