FedInvent™ Patent Applications
Application Details for Thursday, August 18, 2022
This page was updated on Friday, August 19, 2022 at 07:44 PM GMT
Department of Health and Human Services (HHS)
| US 20220256821 | Langenau et al. |
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| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David M. Langenau (Stoneham, Massachusetts); Yan Chuan (Boston, Massachusetts) |
| ABSTRACT | Genetically-modified zebrafish lacking one or more immune-related genes, and the use thereof, e.g., in cell or tissue transplantation methods or in stem cell biology. Tumors, tissues, and cells originating from zebrafish, other fish species, frogs, mouse, human, or other mammals can be readily engrafted into zebrafish that lack specific immune system regulatory genes. Here, described are zebrafish in which the entire genomic regions comprising the coding sequences of genes required for the development of T, B, and NK cells (including NK-lysin expressing cells) are deleted. |
| FILED | Tuesday, July 14, 2020 |
| APPL NO | 17/626728 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0276 (20130101) Original (OR) Class A01K 2207/12 (20130101) A01K 2217/075 (20130101) A01K 2227/40 (20130101) A01K 2267/0331 (20130101) A01K 2267/0393 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 49/006 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5088 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257150 | Gurcan et al. |
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| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Metin Gurcan (Winston-Salem, North Carolina); Aaron Moberly (Columbus, Ohio) |
| ABSTRACT | Disclosed herein are systems and methods to detect a wide range of eardrum conditions by using visually-descriptive words of a tympanic membrane of a subject. |
| FILED | Wednesday, December 08, 2021 |
| APPL NO | 17/545681 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/126 (20130101) Original (OR) Class A61B 5/7264 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257206 | Hartley et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of Leland Stanford Junior University (Stanford, California); Pulmera, Inc. (Redwood City, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bryan I. Hartley (Redwood City, California); Harmeet Bedi (Palo Alto, California); Rene Vargas-Voracek (Sunnyvale, California); Norbert J. Pelc (Aptos, California) |
| ABSTRACT | A method of x-ray fluoroscopy images a region of interest at distinct first and second imaging projection angles using digital subtraction x-ray fluoroscopic imaging with a fiducial marker board positioned in a field of view containing the region of interest to produce first and second sets of images. Image segmentation information is determined to identify an anatomical feature in the region of interest imaged in the first set of images and the second set of images. The region of interest is then imaged using x-ray fluoroscopic imaging, again with the fiducial marker board positioned in a third field of view containing the region of interest, but without digital subtraction, to produce a third set of images. A virtual image of the anatomical feature is projected onto the third set of images, computed from the image segmentation information and from a predetermined geometric relationship of markers within the fiducial marker board. |
| FILED | Friday, April 29, 2022 |
| APPL NO | 17/733772 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/50 (20130101) A61B 6/469 (20130101) A61B 6/487 (20130101) Original (OR) Class A61B 6/0492 (20130101) A61B 6/4441 (20130101) Image Data Processing or Generation, in General G06T 5/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257383 | GORDON et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chad R. GORDON (Baltimore, Maryland); Mehran ARMAND (Baltimore, Maryland); Gerald T. GRANT (Baltimore, Maryland); Peter LIACOURAS (Baltimore, Maryland); Ryan MURPHY (Baltimore, Maryland); Kevin WOLFE (Baltimore, Maryland) |
| ABSTRACT | Provided is a surgical method. The method includes detecting a location of a reference unit having a trackable element with a detector, the detector configured to provide at least one signal corresponding to a detected location of at least the reference unit's trackable element, wherein the reference unit is associated with a location of an anatomical feature of a being's anatomy; accessing a computer-readable reconstruction of the being's anatomy, the computer-readable reconstruction of the being's anatomy having a first updatable orientation, wherein the first updatable orientation is updated in response to the at least one signal; accessing a computer-readable reconstruction of an implant having a second updatable orientation; detecting a location of a pointer tool comprising a trackable element with the detector, the detector further configured to provide at least one other signal corresponding to a detected location of at least the pointer tool, wherein the pointer tool is associated with a location of an anatomical feature of interest; accessing at least one computer-readable reconstruction of a trace, the trace corresponding to a geometry of the anatomical feature of interest based on updated detected locations of the pointer tool; superimposing the at least one updatable, computer-readable trace on the second computer-readable reconstruction of the implant. |
| FILED | Wednesday, October 27, 2021 |
| APPL NO | 17/511987 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 34/10 (20160201) A61B 34/20 (20160201) A61B 2034/108 (20160201) A61B 2034/2068 (20160201) A61B 2090/395 (20160201) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/2875 (20130101) A61F 2/3094 (20130101) A61F 2/30942 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257515 | Mukhopadhyay et al. |
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| FUNDED BY |
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| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
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| INVENTOR(S) | Debabrata Mukhopadhyay (Jacksonville, Florida); Vijay S. Madamsetty (Jacksonville, Florida); Krishnendu Pal (Jacksonville, Florida) |
| ABSTRACT | The present application provides liposomal compositions containing anti-cancer agents and tumor-targeting lipopeptides. The present application also provides nanodiamond complexes and particles as carriers for anti-cancer agents. |
| FILED | Tuesday, June 16, 2020 |
| APPL NO | 17/618389 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1275 (20130101) Original (OR) Class A61K 31/52 (20130101) A61K 31/165 (20130101) A61K 31/337 (20130101) A61K 31/343 (20130101) A61K 31/352 (20130101) A61K 31/353 (20130101) A61K 31/365 (20130101) A61K 31/381 (20130101) A61K 31/433 (20130101) A61K 31/436 (20130101) A61K 31/444 (20130101) A61K 31/475 (20130101) A61K 31/513 (20130101) A61K 31/517 (20130101) A61K 31/519 (20130101) A61K 31/5377 (20130101) A61K 31/5545 (20170801) A61K 31/7068 (20130101) A61K 31/7072 (20130101) A61K 31/7076 (20130101) A61K 47/60 (20170801) A61K 47/6923 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/001 (20130101) C07K 16/2863 (20130101) C07K 19/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257516 | Yantasee et al. |
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| FUNDED BY |
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| APPLICANT(S) | Oregon Health and Science University (Portland, Oregon); PDX Pharmaceuticals, Inc. (Portland, Oregon) |
| ASSIGNEE(S) | Oregon Health and Science University (Portland, Oregon); PDX Pharmaceuticals, Inc. (Portland, Oregon) |
| INVENTOR(S) | Wassana Yantasee (Lake Oswego, Oregon); Moataz Reda (Portland, Oregon); Worapol Ngamcherdtrakul (Portland, Oregon); Ngoc Ha Hoang (Portland, Oregon) |
| ABSTRACT | Disclosed herein are therapeutic constructs including a delivery particle, at least one mitotic kinase inhibitor, and at least one immune checkpoint inhibitor. Also disclosed are therapeutic constructs including a mitotic kinase inhibitor, an immune checkpoint inhibitor, and a chemical linker. These therapeutic constructs cause cancer death by both therapeutic and immune effects and promote targeted delivery of more therapeutics to the surviving cancer cells in a positive feed-back loop. They enhance therapeutic index of free drugs and can be used intratumorally or systemically. This strategy can treat broad cancer types and is particular useful for cancer without obvious receptors for cancer-targeted delivery of otherwise toxic therapeutics. |
| FILED | Monday, July 13, 2020 |
| APPL NO | 17/625331 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/143 (20130101) Original (OR) Class A61K 9/146 (20130101) A61K 45/06 (20130101) A61K 47/6803 (20170801) A61K 47/6849 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257544 | CHANG et al. |
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| FUNDED BY |
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| APPLICANT(S) | Trustees of Dartmouth College (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ta Yuan CHANG (Etna, New Hampshire); Catherine C.Y. CHANG (Etna, New Hampshire); Haibo LI (Hanover, New Hampshire); Adrianna DE LA TORRE (Lyme, New Hampshire); Thao N. HUYNH (Concord, New Hampshire) |
| ABSTRACT | The present invention features compositions and methods for preventing or treating neuroinflammation, amyloidopathy or tauopathy by inhibiting Acyl-CoA:Cholesterol Acyltransferase activity, in particular with brain-permeable inhibitors encapsulated in a stealth liposome-based nanoparticle. Stealth liposome-based nanoparticles for reducing or attenuating amyloidopathy or tauopathy are also provided. |
| FILED | Monday, April 18, 2022 |
| APPL NO | 17/722629 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/127 (20130101) A61K 31/167 (20130101) Original (OR) Class A61K 31/352 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257572 | Bordey et al. |
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| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Angelique Bordey (Guilford, Connecticut); Longbo Zhang (Guilford, Connecticut) |
| ABSTRACT | In various aspects and embodiments the invention provides a method of treating epilepsy in a subject in need thereof, the method comprising providing to the subject an effective amount of an FLNA modulator. In various embodiments, the FLNA modulator is PTI-125 or kartogenin. In various embodiments, the epilepsy is epilepsy associated with focal cortical dysplasia (FCD) type II or tuberous sclerosis complex (TSC). |
| FILED | Thursday, February 13, 2020 |
| APPL NO | 17/430549 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/192 (20130101) A61K 31/438 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/08 (20180101) A61P 25/28 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) G01N 2333/4712 (20130101) G01N 2333/70571 (20130101) G01N 2800/50 (20130101) G01N 2800/2821 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257583 | Fecci et al. |
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| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter Fecci (Durham, North Carolina); Pakawat Chongsathidkiet (Durham, North Carolina); Alem Kahsai (Durham, North Carolina); Robert Lefkowitz (Durham, North Carolina) |
| ABSTRACT | Provided herein are compositions and methods for enhancing egress of T-cells from bone marrow of a subject in need thereof. Also provided are compositions and methods for the treatment of diseases characterized by reduced surface display of sphingosine-1-phosphate receptor 1 (S1P1), as well as methods of diagnosis/prognosis related to surface display of SIP 1. Methods of treating cancer are also provided. |
| FILED | Friday, July 31, 2020 |
| APPL NO | 17/630659 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/12 (20130101) A61K 31/41 (20130101) A61K 31/44 (20130101) A61K 31/58 (20130101) A61K 31/122 (20130101) A61K 31/155 (20130101) A61K 31/196 (20130101) A61K 31/343 (20130101) A61K 31/352 (20130101) A61K 31/365 (20130101) A61K 31/423 (20130101) A61K 31/472 (20130101) Original (OR) Class A61K 31/4045 (20130101) A61K 31/4155 (20130101) A61K 38/193 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257599 | HELLER et al. |
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| FUNDED BY |
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| APPLICANT(S) | Memorial Sloan Kettering Cancer Center (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel HELLER (New York, New York); Christopher HOROSZKO (New York, New York) |
| ABSTRACT | The present technology is directed to methods useful in treating cancer, slowing growth of a tumor, reversing growth of a tumor, slowing growth of a neoplasm, reversing growth of a neoplasm, slowing proliferation of a neoplasm, and/or reversing proliferation of a neoplasm, for cancers, tumors, and neoplasms harboring a constitutively active variant of one or both of KRAS or HRAS, where the constitutively active variant is a gain of function mutation, a duplication, or a gene amplification. |
| FILED | Wednesday, July 15, 2020 |
| APPL NO | 17/626370 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/517 (20130101) Original (OR) Class A61K 31/4709 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257601 | Giancotti et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas); Memorial Sloan Kettering Cancer Center (New York, New York) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas); Memorial Sloan Kettering Cancer Center (New York, New York) |
| INVENTOR(S) | Filippo Giancotti (Houston, Texas); Ouathek Ouerfelli (Fort Lee, New Jersey); Wenjing Su (New York, New York); Guangli Yang (Syosset, New York); Howard Scher (Tenafly, New York); Mohammad Marzabadi (Ridgewood, New Jersey) |
| ABSTRACT | Disclosed herein are compounds and methods for the inhibition of the RNF1 or RNF2 subunit of polycomb repressive complex 1 (PRC1) for the treatment of metastatic cancer, such as metastatic castration-resistant prostate cancer. The inhibitors can be combined with checkpoint inhibitors such as PD-1 inhibitors, PD-L 1 inhibitors, or CTLA-4 inhibitors. |
| FILED | Friday, June 26, 2020 |
| APPL NO | 17/622287 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) Original (OR) Class A61K 31/4035 (20130101) A61K 31/4406 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257603 | GAO |
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| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Jianjun GAO (Houston, Texas) |
| ABSTRACT | Provided herein are methods of treating patients with a combination of an anti-folate agent and an A2BR antagonist. Also provided are methods of treating patients with a combination of an anti-folate agent and an immune checkpoint inhibitor. The patients are selected for treatment based on having an MTAP-deficient cancer. |
| FILED | Monday, June 15, 2020 |
| APPL NO | 17/618778 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/155 (20130101) A61K 31/505 (20130101) A61K 31/513 (20130101) A61K 31/519 (20130101) A61K 31/522 (20130101) Original (OR) Class A61K 39/3955 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257604 | Kester et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| INVENTOR(S) | Mark Kester (Afton, None); Kelly C. Drews (Durham, None) |
| ABSTRACT | Provided are methods and compositions for inhibiting viral infections. In some embodiments, the methods include administering to a subject infected with and/or at risk for infection with a virus a composition having a glucosylceramidase inhibitor, a glucosylceramide synthase inhibitor, or any combination thereof via a route and in an amount effective for treating and/or inhibiting the viral infection in the subject. Also provided are methods for inhibiting viral infections of cells, methods for inhibiting endosomal fusion of viruses in cells, and compositions for use in treating and/or inhibiting viral infections of subjects and/or cells. |
| FILED | Monday, March 09, 2020 |
| APPL NO | 17/437010 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/40 (20130101) A61K 31/133 (20130101) A61K 31/336 (20130101) A61K 31/437 (20130101) A61K 31/445 (20130101) A61K 31/4025 (20130101) A61K 31/5375 (20130101) Original (OR) Class A61K 39/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) Peptides C07K 16/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257606 | JAISWAL et al. |
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| APPLICANT(S) | CHILDREN'S NATIONAL MEDICAL CENTER (Washington, District of Columbia) |
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| INVENTOR(S) | Jyoti JAISWAL (Rockville, Maryland); Marshall HOGARTH (Washington, District of Columbia) |
| ABSTRACT | Disclosed herein are compositions that inhibit adipogenesis of a fibro/adipogenic precursor (FAP) cell and methods relating to treating, preventing, reducing, and/or inhibiting a muscular degenerative condition a muscular degenerative condition comprising administering said inhibitors. |
| FILED | Thursday, July 16, 2020 |
| APPL NO | 17/627203 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/5415 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 2121/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257609 | SMITH et al. |
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| FUNDED BY |
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| APPLICANT(S) | GEORGETOWN UNIVERSITY (Washington, District of Columbia) |
| ASSIGNEE(S) | GEORGETOWN UNIVERSITY (Washington, District of Columbia) |
| INVENTOR(S) | Jill P. SMITH (Camp Hill, Pennsylvania); Louis WEINER (Washington, District of Columbia); Sandra JABLONSKI (Silver Spring, Maryland); Sandeep NADELLA (Alexandria, Virginia); Shangzi WANG (Derwood, Maryland) |
| ABSTRACT | Provided herein are methods for treating a cholecystokinin (CCK) receptor-expressing cancerous tumor in a subject. The methods comprising administering to the subject an effective amount of a CCK receptor inhibitor and an effective amount of an immune checkpoint inhibitor, wherein the CCK receptor inhibitor inhibits one or more CCK receptors selected from the group consisting of a CCK-A receptor, a CCK-B receptor and a CCK-C receptor, and wherein the immune checkpoint inhibitor is a programmed cell death protein 1 (PD1) inhibitor or a cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) inhibitor. |
| FILED | Wednesday, February 23, 2022 |
| APPL NO | 17/678754 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/198 (20130101) A61K 31/5513 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2818 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257612 | Kaddurah-Daouk et al. |
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| FUNDED BY |
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| APPLICANT(S) | Rima F. KADDURAH-DAOUK (Durham, North Carolina); Siamak MAHMOUDIANDEHKORDI (Durham, North Carolina); Cornelia VAN DUIJIN (Oxford, United Kingdom); Shahzad AHMAD (Rotterdam, Netherlands); Andrew J. SAYKIN (Indianapolis, Indiana); Kwangsik NHO (Indianapolis, Indiana); Rebecca BAILLIE (San Carlos, California); Xianlin HAN (San Antonio, Texas); DUKE UNIVERSITY (Durham, North Carolina); OXFORD UNIVERSITY (Oxford,, United Kingdom); ERASMUS MEDICAL CENTER (Rotterdam, Netherlands); INDIANA UNIVERSITY SCHOOL OF MEDICINE (Indianapolis, Indiana); UNIVERSITY OF TEXAS (San Antonio, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rima F. Kaddurah-Daouk (Belmont, Massachusetts); Siamak Mahmoudiandehkordi (Durham, North Carolina); Cornelia van Duijin (Oxford, United Kingdom); Shahzad Ahmad (Rotterdam, Netherlands); Andrew J. Saykin (Indianapolis, Indiana); Kwangsik Nho (Indianapolis, Indiana); Rebecca Baillie (San Carlos, California); Xianlin Han (San Antonio, Texas) |
| ABSTRACT | Described herein are methods for identifying or diagnosing Alzheimer's disease or poor cognition in a subject or population of subjects by analyzing biomarkers. In one aspect, the biomarkers comprise liver function enzymes or metabolites including alanine aminotransferase (ALT), aspartate aminotransferase (AST), ratio of ALT to AST, alkaline phosphatase, albumin, bilirubin, cholesterol and cholesterol metabolites, amino acids, phospholipids, bile acids, or other metabolites. In another aspect, the biomarkers comprise alanine aminotransferase (ALT), aspartate aminotransferase (AST), or the ratio of ALT to AST levels. In another aspect, the marker comprises the genotype of the ALT or AST enzymes. |
| FILED | Friday, July 24, 2020 |
| APPL NO | 17/625046 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/07 (20130101) A61K 31/13 (20130101) A61K 31/27 (20130101) A61K 31/40 (20130101) A61K 31/55 (20130101) A61K 31/60 (20130101) A61K 31/167 (20130101) A61K 31/192 (20130101) A61K 31/196 (20130101) A61K 31/216 (20130101) A61K 31/355 (20130101) A61K 31/366 (20130101) A61K 31/427 (20130101) A61K 31/445 (20130101) A61K 31/475 (20130101) A61K 31/496 (20130101) A61K 31/505 (20130101) A61K 31/506 (20130101) A61K 31/575 (20130101) Original (OR) Class A61K 31/635 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257615 | SCANGARELLA-OMAN |
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| FUNDED BY |
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| APPLICANT(S) | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMIED (Brentford, Middlesex, United Kingdom) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicole SCANGARELLA-OMAN (Collegeville, Pennsylvania) |
| ABSTRACT | The present invention relates to methods for treating bacterial infections caused by or associated with Mycoplasma genitalium, which comprises administration of gepotidacin or pharmaceutically acceptable salts thereof, and doxycycline to a human in need thereof. Novel pharmaceutical combinations, compositions, resistance guided therapies and/or corresponding uses thereof are also disclosed. |
| FILED | Friday, July 03, 2020 |
| APPL NO | 17/619367 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/65 (20130101) Original (OR) Class A61K 31/4985 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257629 | Townes et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE UAB RESEARCH FOUNDATION (Birmingham, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tim Townes (Birmingham, Alabama); Dewang Zhou (Birmingham, Alabama) |
| ABSTRACT | Provided herein are compositions and methods for increasing fetal hemoglobin in a subject in need thereof. Also provided are compositions and methods for treating a hemoglobin disorder in a subject. |
| FILED | Thursday, July 30, 2020 |
| APPL NO | 17/630133 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7072 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257646 | Li et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Huiying Li (Los Angeles, California); Emma Barnard (Los Angeles, California) |
| ABSTRACT | Provided herein are methods and compositions for the treatment or prevention of a skin disease (e.g., acne) in a subject by administering to the subject a composition comprising iron or cobalt. |
| FILED | Friday, July 17, 2020 |
| APPL NO | 17/628079 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) A61K 9/0053 (20130101) A61K 33/26 (20130101) Original (OR) Class A61K 35/74 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/10 (20180101) Specific Use of Cosmetics or Similar Toilet Preparations A61Q 19/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257653 | BOSSE et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Children's Hospital of Philadelphia (Philadelphia, Pennsylvania); THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC (Bethesda, California); THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Standford, California) |
| ASSIGNEE(S) | The Children's Hospital of Philadelphia (Philadelphia, Pennsylvania); THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC (Bethesda, Maryland); THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Standford, California) |
| INVENTOR(S) | Kristopher BOSSE (Philadelphia, Pennsylvania); John MARIS (Philadelphia, Pennsylvania); David BARRETT (Philadelphia, Pennsylvania); Jessica FOSTER (Wynnewood, Pennsylvania); Dimiter DIMITROV (Frederick, None); Crystal MACKALL (Redwood City, California); Robbie MAJZNER (Palo Alto, California); ZHONGYU ZHU (Frederick, Maryland); Sabine HEITZENEDER (Redwood City, California); Dontcho V. JELEV (ROCKVILLE, Maryland) |
| ABSTRACT | The present disclosure is directed to chimeric antigen receptors binding to Glypican 2, nucleic acids encoding the same, and cells expressing the same, and methods of using such cells to treat cancers that express or overexpress the Glypican 2 antigen. |
| FILED | Friday, July 17, 2020 |
| APPL NO | 17/597580 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/7051 (20130101) C07K 14/70517 (20130101) C07K 14/70521 (20130101) C07K 14/70578 (20130101) C07K 16/3053 (20130101) C07K 2317/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257686 | PATNODE et al. |
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| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri); Intercontinental Great Brands LLC (East Hanover, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | MICHAEL PATNODE (St. Louis, Missouri); ZACHARY BELLER (St. Louis, Missouri); NATHAN HAN (St Louis, Missouri); DARRYL WESENER (St. Louis, Missouri); OMAR DELANNOY-BRUNO (St. Louis, Missouri); SOPHIE VINOY (St. Louis, Missouri); JEFFREY GORDON (St. Louis, Missouri); DAVID KAY HAYASHI (St. Louis, Missouri); ALEXANDRA MEYNIER (St. Louis, Missouri); MONIKA OKONIEWSKA (St. Louis, Missouri); VANI VEMULAPALLI (St. Louis, Missouri); MICHAEL BARRATT (St. Louis, Missouri) |
| ABSTRACT | The present disclosure provides compositions and foods that selectively promote the representation and expressed beneficial function of members of a human gut community in ways that promote a healthy gut microbiota and in turn positively impact health. Various examples of compositions and foods, which comprise one or more fiber preparation, are discussed in detail, as are methods of their use. |
| FILED | Friday, July 17, 2020 |
| APPL NO | 17/628491 |
| CURRENT CPC | Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 33/22 (20160801) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/732 (20130101) A61K 31/733 (20130101) A61K 36/48 (20130101) Original (OR) Class A61K 36/752 (20130101) A61K 36/8998 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257714 | Wang et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH (Manhasset, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ping Wang (Roslyn, New York); Haichao Wang (Edison, New Jersey) |
| ABSTRACT | A method of treating a sterile inflammatory condition in a subject using an isolated dermcidin peptide or an active fragment thereof of or an active analog thereof is provided. Also provided is a method of inhibiting organ transplantation-associated ischemia/reperfusion and/or organ transplantation-associated inflammation. |
| FILED | Thursday, March 03, 2022 |
| APPL NO | 17/685993 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0215 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) A61K 9/0019 (20130101) A61K 38/16 (20130101) A61K 38/1729 (20130101) Original (OR) Class A61K 47/60 (20170801) A61K 47/549 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257715 | Sakon et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Little Rock, Arkansas); NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY (Okayama, Japan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joshua Sakon (Fayetteville, Arkansas); Robert Beitle (Fayetteville, Arkansas); Hazim Aljewari (Fayetteville, Arkansas); Osamu Matsushita (Okayama, Japan); Stephanie Beitle (Fayetteville, Arkansas) |
| ABSTRACT | The present invention provides collagen-binding agents that can be used to treat wounds, ischemic heart disease, and other conditions. The collagen-binding agents comprise a therapeutic agent, a protease cleavage site, and a collagen-binding domain. The present invention further provides pharmaceutical compositions and biomedical devices comprising the disclosed collagen-binding agents, as well as methods for treating a condition using the collagen-binding agents. |
| FILED | Friday, February 18, 2022 |
| APPL NO | 17/675762 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) A61K 38/1825 (20130101) Original (OR) Class Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 31/10 (20130101) A61L 31/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257716 | Mangelsdorf et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David J. Mangelsdorf (Dallas, Texas); Steven A. Kliewer (Dallas, Texas); Katie C. Coate (Pelham, Alabama); Genaro Hermandez (Dallas, Texas) |
| ABSTRACT | The present invention relates to the treatment of secretory disorders, and provides novel methods of treatment of these disorders comprising the administration of fibroblast growth factor 21 (FGF21) or derivatives thereof. The methods of the invention are useful in conditions including exocrine pancreatic insufficiency (EPI), for example EPI resulting from cystic fibrosis, alcoholism, pancreatitis, pancreatic cancer, gallstones, celiac disease, high triglycerides, or lupus. The methods of the present invention find further utility in the treatment of salivary flow disorders, for example Sjorgen's syndrome, and the prevention of EPI or pancreatitis resulting from surgical procedures. |
| FILED | Friday, March 11, 2022 |
| APPL NO | 17/693057 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0053 (20130101) A61K 38/1825 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/18 (20180101) Peptides C07K 14/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257718 | Yates-Binder et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); Tuskegee University (Tuskegee, Alabama) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); Tuskegee University (Tuskegee, Alabama) |
| INVENTOR(S) | Cecelia C. Yates-Binder (Pittsburgh, Pennsylvania); Jesse Jaynes (Tuskegee, Alabama) |
| ABSTRACT | Interferon-γ-inducible protein 10 (IP-10) peptides, IP-10 peptide variants and in silico designed C—X—C chemokine receptor 3 (CXCR3) peptide agonists are described. The small peptides can be used for inhibiting pathological tissue remodeling and treating fibrosis in a subject, such as a subject with fibrosis of the heart, lung, liver, kidney or skin. The peptide agonists can also be used to treat cardiovascular disease, including myocardial infarction and ischemia-reperfusion injury. Also described are in silico designed peptide antagonists that bind CXCR3 or ligands of CXCR3. These antagonist peptides block CXCR3 signaling by disrupting interaction of CXCR3 with its ligand. Antagonist peptides can be used, for example, to treat myocarditis and atherosclerosis. In additional embodiments agonists and antagonists of CXCR4 are disclosed. |
| FILED | Wednesday, April 20, 2022 |
| APPL NO | 17/724900 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/195 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) A61P 35/00 (20180101) Peptides C07K 7/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/62 (20130101) C12N 15/86 (20130101) C12N 15/113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257725 | Nuebel et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Utah Research Foundation (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Esther Nuebel (Salt Lake, Utah); Jared Rutter (Salt Lake, Utah); Yu-Chan Chen (San Jose, California); Joshua Bonkowsky (Salt Lake City, Utah) |
| ABSTRACT | Disclosed herein are compositions and methods for treating mitochondrial dysfunction. The methods can include compositions capable of increasing or overexpressing ATAD1. The methods include restoring mitochondrial respiration and ATP production. The present disclosure provides a mechanism for peroxin (peroxisomal biogenesis factors) accumulation on mitochondria that affects respiration and ATP generation. |
| FILED | Friday, July 10, 2020 |
| APPL NO | 17/625514 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/197 (20130101) A61K 31/4015 (20130101) A61K 38/46 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257740 | FRÜH et al. |
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| FUNDED BY |
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| APPLICANT(S) | Oregon Health and Science University (Portland, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Klaus J. FRÜH (Portland, Oregon); Scott G. HANSEN (Portland, Oregon); Louis J. PICKER (Portland, Oregon) |
| ABSTRACT | The present disclosure relates to antigens and methods of generating an immune response for the treatment of cancer. The disclosure also relates to methods of generating MHC-Ia, MHC-II, and/or MHC-E restricted CD8+ T cells for the treatment or prevention of cancer. |
| FILED | Friday, June 05, 2020 |
| APPL NO | 17/616941 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 39/001153 (20180801) Original (OR) Class A61K 39/001193 (20180801) A61K 2039/53 (20130101) A61K 2039/605 (20130101) A61K 2039/5158 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257742 | EAPPEN et al. |
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| FUNDED BY |
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| APPLICANT(S) | Sanaria Inc. (Rockville, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Abraham G. EAPPEN (Ellicott City, Maryland); Stephen L. HOFFMAN (Gaithersburg, Maryland) |
| ABSTRACT | The application is directed to in vitro-reared Plasmodium sporozoites of human host range wherein sporogony from gametocyte stage to sporozoite stage is external to mosquitoes, and methods of producing the same. Provided herein are in vitro-reared infectious Plasmodium sporozoites (SPZ) of human host range, particularly P. falciparum, P. vivax, P. ovale, P. malariae, and P. knowlesi, wherein sporogony from gametocyte stage to sporozoite stage is external to mosquitoes, and methods of producing the same. |
| FILED | Thursday, November 18, 2021 |
| APPL NO | 17/529812 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/015 (20130101) Original (OR) Class A61K 2039/52 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257744 | AMAN et al. |
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| FUNDED BY |
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| APPLICANT(S) | INTEGRATED BIOTHERAPEUTIC VACCINES, INC. (Rockville, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mohammad Javad AMAN (Rockville, Maryland); Thomas KORT (Rockville, Maryland); Arundhathi VENKATASUBRAMANIAM (Rockville, Maryland); Nils WILLISTON (Rockville, Maryland); Rajan Prasad ADHIKARI (Rockville, Maryland); Frederick W. HOLTSBERG (Rockville, Maryland) |
| ABSTRACT | The present disclosure provides immunogenic compositions useful in prevention and treatment of Staphylococcus aureus infection. In particular, the disclosure provides multivalent oligopeptides, fusion proteins comprising two or more staphylococcal superantigen (SAg) proteins, or any fragments, variants, or derivatives thereof fused together as a single polypeptide in any order. |
| FILED | Friday, February 25, 2022 |
| APPL NO | 17/680897 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/085 (20130101) Original (OR) Class A61K 2039/53 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/70 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257748 | FRÜH et al. |
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| FUNDED BY |
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| APPLICANT(S) | Oregon Health and Science University (Portland, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Klaus J. FRÜH (Portland, Oregon); Louis J. PICKER (Portland, Oregon); Benjamin J. BURWITZ (Portland, Oregon); Scott G. HANSEN (Portland, Oregon); Jonah B. SACHA (Beaverton, Oregon) |
| ABSTRACT | The present disclosure relates to methods to generate an immune response for the treatment or prevention of hepatitis B virus infection. This disclosure also relates to methods to generate MHC-E and/or MHC-II restricted CD8+ T cells for the treatment or prevention of hepatitis B virus infection. |
| FILED | Friday, June 05, 2020 |
| APPL NO | 17/616939 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class A61K 39/001129 (20180801) A61K 47/30 (20130101) A61K 2039/572 (20130101) A61K 2039/5256 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/12 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257749 | PALESE et al. |
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| FUNDED BY |
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| APPLICANT(S) | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (New York, New York) |
| ASSIGNEE(S) | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (New York, New York) |
| INVENTOR(S) | Peter PALESE (New York, New York); Adolfo GARCIA-SASTRE (New York, New York); Megan ERMLER (New York, New York); Florian KRAMMER (New York, New York) |
| ABSTRACT | Provided herein are chimeric hemagglutinin (HA) polypeptides and uses thereof for inducing an immune response (e.g., an antibody response) against influenza virus. Also provided herein are methods of generating antibodies to the chimeric HA polypeptides in a subject. |
| FILED | Monday, January 24, 2022 |
| APPL NO | 17/583088 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/145 (20130101) Original (OR) Class A61K 2039/525 (20130101) Peptides C07K 14/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257754 | FOX |
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| FUNDED BY |
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| APPLICANT(S) | ACCESS TO ADVANCED HEALTH INSTITUTE (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher B. FOX (Sumner, Washington) |
| ABSTRACT | Stable aqueous formulations of adjuvant comprising a TLR7/8 agonist or a TLR4 agonist with a helper lipid that are adsorbed to alum are provided. Compositions and methods of using the formulations for stimulating an immune response are also provided. |
| FILED | Thursday, April 28, 2022 |
| APPL NO | 17/731718 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/76 (20130101) A61K 39/04 (20130101) A61K 39/12 (20130101) A61K 39/39 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 2039/55505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/06 (20180101) A61P 31/12 (20180101) A61P 33/04 (20180101) A61P 35/00 (20180101) Peptides C07K 14/705 (20130101) C07K 14/70596 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257796 | Kiem et al. |
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| FUNDED BY |
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| APPLICANT(S) | Fred Hutchinson Cancer Research Center (Seattle, Washington); University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | Fred Hutchinson Cancer Research Center (Seattle, Washington); University of Washington (Seattle, Washington) |
| INVENTOR(S) | Hans-Peter Kiem (Seattle, Washington); Andre Lieber (Seattle, Washington); Chang Li (Seattle, Washington); Hongjie Wang (Seattle, Washington) |
| ABSTRACT | The present disclosure provides, among other things, helper-dependent adenoviral serotype 35 (Ad35) vectors. In various embodiments, helper-dependent Ad35 vectors can be used to deliver a therapeutic payload to a subject in need thereof. Exemplary payloads can encode replacement proteins, antibodies, CARs, TCRs, small RNAs, and genome editing systems. In certain embodiments, a helper-dependent Ad35 vector is engineered for integration of a payload into a host cell genome. The present disclosure further includes methods of gene therapy that include administration of a helper-dependent Ad35 vector to a subject in need thereof. |
| FILED | Thursday, July 02, 2020 |
| APPL NO | 17/618774 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/0091 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/86 (20130101) C12N 15/111 (20130101) C12N 15/113 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) C12N 2710/10343 (20130101) C12N 2800/80 (20130101) C12N 2800/90 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257827 | Boire et al. |
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| FUNDED BY |
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| APPLICANT(S) | VenoStent, Inc. (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Timothy C. Boire (Houston, Texas); Jordan S. Miller (Houston, Texas); Bagrat Grigoryan (Houston, Texas); Candice Sears (Houston, Texas) |
| ABSTRACT | Various precursor solutions and methods of 3D printing and other additive manufacturing approaches are provided for the manufacture of articles using photocrosslinkable vinyl shape memory polymers. In various aspects, articles are manufactured by a process comprising (i) exposing a precursor solution to an intensity and frequency of light to initiate photo-polymerization of the precursor solution to form a layer of the article; and (ii) repeating step (i) a number of times to form the article in a layer-by-layer approach; wherein the precursor solution comprises a first polymeric precursor comprising a plurality of vinyl terminated side-chains attached thereto. A vinyl-functionalized, photocrosslinkable SMP used as an example herein is a novel variant of a previously disclosed SMP composition, with higher amounts of vinyl functionalization but similar thermomechanical properties to the SMP library previously disclosed. Moreover, a unique combination of chemistries is disclosed that incorporates the aforementioned vinyl-functionalized SMPs along with acrylate-based crosslinkers. Additional novel compositions are disclosed containing the vinyl-functionalized SMPs with additional dithiol functionalizations, vinyl-functionalized SMPs with dithiol crosslinkers, as well as vinyl-functionalized SMPs with both acrylate-based and dithiol crosslinkers, as another means to tune degradation rates and other material properties. The articles can include a variety of articles such as stents, grafts, external sheaths, and the like. Beneficially, the printed articles can include a plurality of pores having an average diameter of about 50 pm to about 5000 pm, about 500 pm to about 2000 pm, or about 1000 pm even in the absence of a photoblocker. |
| FILED | Thursday, July 23, 2020 |
| APPL NO | 17/629621 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) Original (OR) Class A61L 27/58 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/129 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 70/00 (20141201) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/08 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/24 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/09 (20130101) C08K 5/0025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257857 | DASSAU et al. |
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| FUNDED BY |
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| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Eyal DASSAU (Acton, Massachusetts); Francis J. DOYLE III (Chestnut Hill, Massachusetts); Stamatina ZAVITSANOU (Cambridge, Massachusetts); Ankush CHAKRABARTY (Boston, Massachusetts) |
| ABSTRACT | The development of artificial pancreas (AP) technology for deployment in low-energy, embedded devices is contingent upon selecting an efficient control algorithm for regulating glucose in people with type 1 diabetes mellitus (T1DM). The energy consumption of the AP can be lowered by reducing updates of the control model: the number of times the decisionmaking algorithm is invoked to compute an appropriate insulin dose. |
| FILED | Thursday, July 06, 2017 |
| APPL NO | 16/314737 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/1723 (20130101) Original (OR) Class A61M 2205/52 (20130101) A61M 2230/201 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/17 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257935 | Pena et al. |
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| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edgar Pena (Durham, North Carolina); Nicole A. Pelot (Durham, North Carolina); Warren Grill (Durham, North Carolina) |
| ABSTRACT | The present disclosure provides systems and methods relating to neuromodulation. In particular, the present disclosure provides systems and methods for selective and/or unidirectional nerve fiber conduction block though the application of a hybrid waveform using a neuromodulation device. The systems and methods of neuromodulation disclosed herein facilitate the treatment of various diseases associated with pathological neural activity. |
| FILED | Thursday, February 17, 2022 |
| APPL NO | 17/674212 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/279 (20210101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/06 (20130101) Original (OR) Class A61N 1/0529 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257936 | Lim et al. |
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| FUNDED BY |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (MINNEAPOLIS, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kelvin O. Lim (Minneapolis, Minnesota); Jazmin Camchong (Minneapolis, Minnesota) |
| ABSTRACT | The neuromodulation system can include a headpiece comprising. The headpiece can include a first surface, a second surface opposite the first surface, and a plurality of electrodes coupled to the first surface of the headpiece, each of the plurality of electrodes can have a known spatial relationship to each other. The neuromodulation system can include at least one placement marker coupled to the second surface. The at least one placement marker can have a known spatial relationship to each of the plurality of electrodes in order to facilitate correct positioning of the headpiece relative to an anatomical feature of a user. The neuromodulation system can include an electrical signal generator in communication with the plurality of electrodes, and a controller device in communication with the electrical signal generator and configured to operate the electrical signal generator in order to generate an electrical stimulation using the plurality of electrodes. |
| FILED | Monday, June 15, 2020 |
| APPL NO | 17/618750 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/08 (20130101) Original (OR) Class A61N 1/025 (20130101) A61N 1/0472 (20130101) Image Data Processing or Generation, in General G06T 7/73 (20170101) G06T 2207/30004 (20130101) G06T 2207/30196 (20130101) G06T 2207/30204 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257982 | HACHADORIAN et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rachael HACHADORIAN (Norwich, Vermont); Brian POGUE (Hanover, New Hampshire); Petr BRUZA (Lebanon, New Hampshire); Lesley JARVIS (Hanover, New Hampshire) |
| ABSTRACT | A system for monitoring radiation treatment images Cherenkov emissions from tissue of a subject. A processor of the system determines densities of a surface layer of the subject from 3D images of the tissue to determine correction factors. The processor uses these factors to correct the Cherenkov images for attenuation of Cherenkov light by tissue, making them proportional to radiation dose. In embodiments, the system obtains reflectance images of the subject, determines second correction factors therefrom, and applies the second correction factors to the Cherenkov emissions images. In embodiments, the corrected images of Cherenkov emissions are compared to dose maps of a treatment plan. A method of correcting Cherenkov emissions images includes determining tissue characteristics from CT or MRI images in a surface volume where Cherenkov is expected, using; imaging Cherenkov emissions; and using the tissue characteristics to correct the images for variations in Cherenkov light propagation through the tissue. |
| FILED | Wednesday, July 15, 2020 |
| APPL NO | 17/627633 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/1071 (20130101) Original (OR) Class A61N 2005/1059 (20130101) Measurement of Nuclear or X-radiation G01T 1/22 (20130101) G01T 1/2992 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220258164 | Zhu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Ying Zhu (Richland, Washington); Jongmin Woo (Richland, Washington); Ljiljana Pasa-Tolic (Richland, Washington) |
| ABSTRACT | A device for biological sample preparation and analysis is disclosed. The device includes a substrate and a plurality of spaced apart arrays disposed on an upper surface of the substrate. Each array includes a plurality of reaction vessels, each reaction vessel having a hydrophilic surface. A hydrophilic ring surrounds each array. Methods of making and using the device are also disclosed. |
| FILED | Wednesday, February 16, 2022 |
| APPL NO | 17/673407 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5088 (20130101) B01L 3/50853 (20130101) B01L 3/502707 (20130101) B01L 3/502753 (20130101) B01L 3/502792 (20130101) Original (OR) Class B01L 2200/12 (20130101) B01L 2200/16 (20130101) B01L 2200/142 (20130101) B01L 2300/165 (20130101) B01L 2300/0819 (20130101) B01L 2300/0822 (20130101) B01L 2300/0887 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/12 (20130101) G01N 33/6851 (20130101) G01N 2030/027 (20130101) G01N 2560/00 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/11 (20130101) G03F 7/32 (20130101) G03F 7/0392 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259144 | ZHANG |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VIRGINIA COMMONWEALTH UNIVERSITY (Richmond, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shijun ZHANG (Glen Allen, Virginia) |
| ABSTRACT | Scaffold compounds are used to design small molecule compounds and structure-activity relationship studies identify inhibitors of inflammation. Methods include pharmaceutical compositions of the small molecule compounds to inhibit, prevent and treat diseases and conditions associated with inflammation, including multiple sclerosis, Alzheimer's disease, acute myocardial infarction, traumatic brain injury and autoinflammatory diseases. |
| FILED | Wednesday, July 15, 2020 |
| APPL NO | 17/627214 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/02 (20180101) Acyclic or Carbocyclic Compounds C07C 311/37 (20130101) Original (OR) Class C07C 311/46 (20130101) Heterocyclic Compounds C07D 207/20 (20130101) C07D 209/14 (20130101) C07D 233/26 (20130101) C07D 241/12 (20130101) C07D 249/04 (20130101) C07D 277/56 (20130101) C07D 277/593 (20130101) C07D 285/06 (20130101) C07D 307/64 (20130101) C07D 317/62 (20130101) C07D 333/24 (20130101) C07D 409/12 (20130101) C07D 413/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259154 | BERLIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arvinas Operations, Inc. (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael BERLIN (Flemington, New Jersey); Andrew P. CREW (Chester, Connecticut); Craig M. CREWS (New Haven, Connecticut); Hanqing DONG (Madison, Connecticut); Keith R. HORNBERGER (Southbury, Connecticut); Lawrence B. SNYDER (Killingworth, Connecticut); Jing WANG (Milford, Connecticut); Kurt ZIMMERMANN (Durham, Connecticut) |
| ABSTRACT | The present disclosure relates to bifunctional compounds, which find utility to degrade (and inhibit) Androgen Receptor. In particular, the present disclosure is directed to compounds, which contain on one end a cereblon ligand which binds to the E3 ubiquitin ligase and on the other end a moiety which binds Androgen Receptor, such that Androgen Receptor is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of Androgen Receptor. The present disclosure exhibits a broad range of pharmacological activities associated with compounds according to the present disclosure, consistent with the degradation/inhibition of Androgen Receptor. |
| FILED | Wednesday, December 01, 2021 |
| APPL NO | 17/539679 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/02 (20130101) A61K 31/166 (20130101) A61K 31/277 (20130101) A61K 31/496 (20130101) A61K 31/497 (20130101) A61K 31/501 (20130101) A61K 31/506 (20130101) A61K 45/06 (20130101) A61K 47/10 (20130101) Heterocyclic Compounds C07D 205/04 (20130101) C07D 209/48 (20130101) C07D 211/76 (20130101) C07D 213/72 (20130101) C07D 221/20 (20130101) C07D 231/12 (20130101) C07D 233/42 (20130101) Original (OR) Class C07D 237/08 (20130101) C07D 239/24 (20130101) C07D 241/04 (20130101) C07D 401/04 (20130101) C07D 401/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259161 | Pomper et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin G. Pomper (Baltimore, None); Ronnie C. Mease (Fairfax, None); Ying Chen (Timonium, None); Sangeeta Ray (Ellicott City, None) |
| ABSTRACT | Compositions and methods for visualizing tissue under illumination with near-infrared radiation, including compounds comprising near-infrared, closed chain, sulfo-cyanine dyes and prostate specific membrane antigen ligands are disclosed. |
| FILED | Tuesday, April 12, 2022 |
| APPL NO | 17/718812 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/0032 (20130101) A61K 49/0052 (20130101) A61K 51/044 (20130101) A61K 51/0421 (20130101) A61K 51/0446 (20130101) A61K 51/0453 (20130101) A61K 51/0472 (20130101) Heterocyclic Compounds C07D 209/12 (20130101) C07D 209/14 (20130101) C07D 209/24 (20130101) C07D 213/04 (20130101) C07D 249/04 (20130101) C07D 255/02 (20130101) C07D 257/02 (20130101) Original (OR) Class C07D 311/14 (20130101) C07D 311/20 (20130101) C07D 311/82 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/027 (20130101) C07F 13/005 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5091 (20130101) G01N 2800/342 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259189 | Rodriguez-Hornedo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Naír Rodriguez-Hornedo (Ann Arbor, Michigan); Gislaine Kuminek (Ann Arbor, Michigan); Katie L. Cavanagh (Ann Arbor, Michigan) |
| ABSTRACT | The disclosure generally relates to cocrystals of posaconazole and a coformer. The disclosure further relates to pharmaceutical compositions comprising the cocrystals, as well as methods of making the cocrystals, and methods of treating or preventing fungal, yeast, or dermatophyte infections using the cocrystals. |
| FILED | Friday, July 31, 2020 |
| APPL NO | 17/629899 |
| CURRENT CPC | General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/13 (20130101) Heterocyclic Compounds C07D 405/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259200 | STROVEL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ConverGene, LLC (Cambridge, Maryland); THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVI (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey W. STROVEL (Laurel, Maryland); Makoto YOSHIOKA (Gaithersburg, Maryland); David J. MALONEY (Point of Rocks, Maryland); Shyh Ming YANG (Doylestown, Pennsylvania); Ajit JADHAV (Chantilly, Virginia); Daniel Jason URBAN (Poolesville, Maryland) |
| ABSTRACT | The present invention relates to compounds that bind to and otherwise modulate the activity of bromodomain-containing proteins, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders. |
| FILED | Wednesday, March 11, 2020 |
| APPL NO | 17/605469 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 413/14 (20130101) C07D 471/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259218 | Mulcahy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SITEONE THERAPEUTICS, INC. (South San Francisco, California); THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Mulcahy (Redwood City, California); Hassan Pajouhesh (Mountain View, California); George Miljanich (Redwood City, California); Anton Delwig (Albany, California); Jacob Beckley (Bozeman, Montana); Grant Masaaki Shibuya (South San Francisco, California); Justin Du Bois (Menlo Park, California) |
| ABSTRACT | Provided herein are compounds, pharmaceutical compositions comprising the compounds, methods of preparing the compounds, and methods of using the compounds and compositions in treating conditions associated with voltage-gated sodium channel function where the compounds are 11,13-modified saxitoxins according to Formula (I): where R4, R4a, R7, R7a, and X2 are as described herein. |
| FILED | Wednesday, January 26, 2022 |
| APPL NO | 17/585530 |
| CURRENT CPC | Heterocyclic Compounds C07D 487/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259244 | MORROW et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for The State University of New York (Buffalo, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Janet R. MORROW (Williamsville, New York); Eric M. SNYDER (Williamsville, New York); Didar ASIK (Buffalo, New York) |
| ABSTRACT | Provided are macrocyclic compounds and compounds with two or more macrocyclic groups, iron coordinated macrocyclic compounds, and iron coordinated compounds with two or more macrocyclic groups. The iron is high-spin iron(III). The iron coordinated compounds may exhibit a negative redox potential (e.g., relative to a normal hydrogen electrode at a biologically relevant pH, for example, a pH of 6.5-7.5). The compounds can be used as MRI contrast agents. |
| FILED | Monday, February 28, 2022 |
| APPL NO | 17/682695 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/085 (20130101) A61K 49/106 (20130101) A61K 49/124 (20130101) A61K 49/128 (20130101) A61K 49/143 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 15/025 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259269 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); The Broad Institute, Inc. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); The Broad Institute, Inc. (Cambridge, Massachusetts) |
| INVENTOR(S) | David R. Liu (Cambridge, Massachusetts); Travis R. Blum (Cambridge, Massachusetts) |
| ABSTRACT | The disclosure provides amino acid sequence variants of Botulinum neurotoxin F (BoNT F) proteases that cleave SNARE proteins (e.g., VAMP1, VAMP7, etc.) and methods of evolving the same. In some embodiments, proteases described by the disclosure are useful for cleaving proteins found in a cell, that is in an intracellular environment. In some embodiments, proteases described by the disclosure are useful for treating diseases associated with increased or aberrant VAMP7 expression or activity, for example, cancer, transplantation rejection, graft-versus-host disease, and neurological disorders. Some aspects of this disclosure provide methods for generating BoNT protease variants by continuous directed evolution. |
| FILED | Tuesday, July 14, 2020 |
| APPL NO | 17/627035 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/33 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/52 (20130101) Enzymes C12Y 304/24069 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259273 | Frydman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); The University of Leeds (West Yorkshire, United Kingdom); University of Konstanz (Konstanz, Germany) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Judith Frydman (Stanford, California); Sheena E. Radford (Leeds, United Kingdom); Elke Deuerling (Konstanz, Germany) |
| ABSTRACT | Compositions and methods for treating aggregation-associated diseases are disclosed. In particular, compositions comprising the nascent polypeptide-associated complex (NAC) and the apical domain of CCT1 as well as peptide fragments thereof and fusion proteins containing NAC and CCT1 peptides can be used to suppress pathological protein aggregation and are useful for treatment of diseases associated with polyQ aggregation, amyloid beta aggregation, and alpha-synuclein aggregation. |
| FILED | Wednesday, March 04, 2020 |
| APPL NO | 17/435628 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0085 (20130101) A61K 38/00 (20130101) A61K 47/6903 (20170801) A61K 47/6911 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Peptides C07K 14/47 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259274 | HAZRA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tapas HAZRA (Galveston, Texas); Sanjiv SUR (Galveston, Texas); Ashok CHOPRA (Galveston, Texas) |
| ABSTRACT | Certain embodiments are directed to NEIL2 compositions and method of using NEIL2 composition to treat subjects in need of such treatment. |
| FILED | Monday, April 11, 2022 |
| APPL NO | 17/717313 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) A61P 31/04 (20180101) Peptides C07K 14/47 (20130101) Original (OR) Class C07K 2319/01 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/85 (20130101) C12N 2015/8518 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259275 | Ramakrishnan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Parameswaran Ramakrishnan (Solon, Ohio); Jonathan K. Pokorski (San Diego, California) |
| ABSTRACT | The present disclosure relates to peptoids for inhibiting O-GlcNAcylated proteins, and in particular, the c-Rel peptide of NF-kappaB. The compounds can be used in the prevention or treatment of diseases of conditions having elevated levels of O-GlcNAcylation, such as autoimmune diseases, conditions that are related to hyperglycemia, or cancers. |
| FILED | Thursday, May 28, 2020 |
| APPL NO | 17/595960 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) A61P 37/00 (20180101) Peptides C07K 14/4703 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259276 | LIN |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MASONIC MEDICAL RESEARCH LABORATORY (Utica, New York) |
| ASSIGNEE(S) | MASONIC MEDICAL RESEARCH LABORATORY (Utica, New York) |
| INVENTOR(S) | Zhiqiang LIN (Utica, New York) |
| ABSTRACT | Provided is a polynucleotide, including a cis-regulatory element and a nucleotide sequence encoding a vestigial like 4 protein, wherein the cis-regulatory element includes an uncoupling protein 1 enhancer and an uncoupling protein 1 promoter. Also provided is a viral vector including said polynucleotide. Also provided is a method of transfecting a cell or a subject with said polynucleotide or said viral vector. |
| FILED | Wednesday, April 27, 2022 |
| APPL NO | 17/731201 |
| CURRENT CPC | Peptides C07K 14/4705 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2750/14143 (20130101) C12N 2830/001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259288 | LEY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY (La Jolla, California) |
| ASSIGNEE(S) | LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY (La Jolla, California) |
| INVENTOR(S) | Klaus LEY (La Jolla, California); Alessandro SETTE (La Jolla, California) |
| ABSTRACT | Provided herein are composition comprising novel epitopes of ApoB100, as well as sub-sequences, portions and modifications thereof, and uses thereof for treating adverse cardiovascular events, cardiovascular disease, atherosclerosis and certain liver disorders. |
| FILED | Monday, September 27, 2021 |
| APPL NO | 17/486820 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/10 (20130101) A61K 38/1709 (20130101) A61K 39/0005 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) A61P 9/10 (20180101) Peptides C07K 7/08 (20130101) C07K 14/775 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259302 | DUGAN |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Laura Lee DUGAN (Brentwood, Tennessee) |
| ABSTRACT | Disclosed are methods of reducing age-dependent lysosome impairment and/or treating an age related neurodegenerative disease, fibrotic disease, or rheumatological disease in a subject comprising administering to the subject a therapeutic agent; wherein the therapeutic agent inhibits nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase (NOX) or downstream NOX effector. |
| FILED | Monday, May 02, 2022 |
| APPL NO | 17/734821 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Peptides C07K 16/248 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259312 | Diaz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Luis Diaz (Ellicot City, Maryland); Bert Vogelstein (Baltimore, Maryland); Kenneth W. Kinzler (Baltimore, Maryland); Nickolas Papadopoulos (Towson, Maryland); Dung Le (Lutherville, Maryland); Drew M. Pardoll (Brookville, Maryland); Suzanne L. Topalian (Brookville, Maryland) |
| ABSTRACT | Blockade of immune checkpoints such as cytotoxic T-lymphocyte antigen-4 (CTLA-4) and programmed death-1 (PD-1) shows promise in patients with cancer. Inhibitory antibodies directed at these receptors have been shown to break immune tolerance and promote anti-tumor immunity. These agents work particularly well in patients with a certain category of tumor. Such tumors may be particularly susceptible to treatment because of the multitude of neoantigens which they produce. |
| FILED | Monday, May 09, 2022 |
| APPL NO | 17/739278 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Peptides C07K 16/30 (20130101) C07K 16/40 (20130101) C07K 16/2803 (20130101) Original (OR) Class C07K 16/2818 (20130101) C07K 16/2827 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) Enzymes C12Y 113/11052 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259317 | Chien et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Christopher D. Chien (Falls Church, Virginia); Terry J. Fry (Bethesda, Maryland) |
| ABSTRACT | An embodiment of the invention provides a chimeric antigen receptor (CAR) comprising an antigen binding domain specific for FLT3, a transmembrane domain, and an intracellular T cell signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of a proliferative disorder, e.g., cancer, in a mammal and methods of treating or preventing a proliferative disorder, e.g., cancer, in a mammal are also disclosed. |
| FILED | Tuesday, March 08, 2022 |
| APPL NO | 17/689698 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 39/395 (20130101) A61K 2039/505 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2809 (20130101) C07K 16/2815 (20130101) C07K 16/2863 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/53 (20130101) C07K 2317/64 (20130101) C07K 2317/622 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57426 (20130101) G01N 33/57492 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259322 | HALLAHAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | DENNIS HALLAHAN (St. Louis, Missouri); ABHAY KUMAR SINGH (St. Louis, Missouri); VAISHALI KAPOOR (St. Louis, Missouri) |
| ABSTRACT | The present invention is directed towards isolated antibodies that bind to GRP78. Specifically, compositions comprising anti-GRP78 antigen binding proteins useful in recognition of cancer or tumor cells. Moreover, in some aspects, the anti-GRP78 antigen binding proteins are useful for tumor/cancer-specific delivery of drugs and therapies. In another aspect, the disclosed antigen binding proteins are useful for enhancing radiotherapy in a subject having or suspected of having cancer or a tumor where the antigen binding protein is conjugated to a payload, for example, a therapeutic agent, an imaging agent, or a combination thereof. |
| FILED | Thursday, July 16, 2020 |
| APPL NO | 17/627502 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/10 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/30 (20130101) Original (OR) Class C07K 2317/34 (20130101) C07K 2317/56 (20130101) C07K 2317/622 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259323 | Eavarone et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Seagen Inc. (Bothell, Washington) |
| ASSIGNEE(S) | Seagen Inc. (Bothell, Washington) |
| INVENTOR(S) | David A. Eavarone (North Quincy, Massachusetts); Jillian M. Prendergast (Maynard, Massachusetts); Jeffrey Behrens (Newton, Massachusetts) |
| ABSTRACT | The present invention provides glycan-interacting antibodies and methods for producing glycan-interacting antibodies useful in the treatment and prevention of human disease, including cancer. Such glycan-interacting antibodies include humanized antibodies, derivatives and fragments thereof as well as related compositions and kits. Methods of using glycan-interacting antibodies for treatment and diagnosis are included. |
| FILED | Wednesday, December 01, 2021 |
| APPL NO | 17/539389 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6803 (20170801) A61K 47/6817 (20170801) A61K 47/6851 (20170801) A61K 2039/572 (20130101) Peptides C07K 16/3084 (20130101) Original (OR) Class C07K 16/3092 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259332 | GORDON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | JEFFREY I. GORDON (St. Louis, Missouri); DARRYL WESENER (St. Louis, Missouri); MICHAEL PATNODE (St Louis, Missouri) |
| ABSTRACT | The present disclosure provides retrievable artificial food particles comprising one or more compound of interest, and methods of using the artificial food particles. The methods disclosed herein can be used to characterize the composition and/or functional state of a subjects gut microbiota. Other aspects of the compositions and methods are described in further detail. |
| FILED | Friday, July 17, 2020 |
| APPL NO | 17/628497 |
| CURRENT CPC | Polysaccharides; Derivatives Thereof C08B 37/0003 (20130101) Original (OR) Class C08B 37/0006 (20130101) C08B 37/006 (20130101) Compositions of Macromolecular Compounds C08L 3/02 (20130101) C08L 5/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259574 | Ai et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Huiwang Ai (Crozet, Virginia); Hsien-Wei Yeh (Seattle, Washington); Ying Xiong (Charlottesville, Virginia) |
| ABSTRACT | Provided herein are chemically modified luciferase substrates for spectrally shifted emission and enhanced water solubility. Provided herein are engineered luciferases. Moreover, provided herein are new ATP-independent bioluminescent reporters which have improved biochemical and photophysical properties and are expected to have broad applications. Finally, provided herein are spectral-resolved triple-color bioluminescent systems, suitable for flexible and convenient approaches to monitor multiple biological events in either qualitative or quantitative manners |
| FILED | Thursday, February 27, 2020 |
| APPL NO | 17/434351 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0069 (20130101) Original (OR) Class C12N 15/63 (20130101) Enzymes C12Y 113/12005 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/542 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259576 | HA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Israel) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Taekjip HA (Baltimore, Maryland); Sinan ARSLAN (Urbana, Illinois) |
| ABSTRACT | Conformationally-constrained helicases having improved activity and strength are provided. Methods of making conformationally-constrained helicases having improved activity and strength are provided. Methods of using conformationally-constrained helicases having improved activity and strength are provided. |
| FILED | Monday, November 29, 2021 |
| APPL NO | 17/537419 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/14 (20130101) Original (OR) Class C12N 9/90 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Enzymes C12Y 306/04012 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259581 | Romney et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | David K. Romney (Pasadena, California); Javier Murciano Calles (Ubeda Jaen, Spain); Jori E. Wehrmuller (Hohenrain, Switzerland) |
| ABSTRACT | This disclosure relates to modified tryptophan synthase and more particularly to modified beta-subunits of tryptophan synthase. The disclosure further relates to cells expressing such modified subunits and methods of producing non-canonical amino acids. |
| FILED | Tuesday, April 19, 2022 |
| APPL NO | 17/724390 |
| CURRENT CPC | Heterocyclic Compounds C07D 209/20 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/88 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 13/227 (20130101) Enzymes C12Y 402/0102 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259585 | Liu |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | The Texas A and M University System (College Station, Texas) |
| INVENTOR(S) | Wenshe Liu (College Station, Texas) |
| ABSTRACT | Embodiments of the present disclosure pertain to methods of constructing a phage display library where at least 90% of combinatorial regions in the phage display library include at least one in-frame amber codon. Further embodiments of the present disclosure pertain to the formed phage display libraries. Additional embodiments of the present disclosure pertain to methods of selecting peptides or proteins that bind to a desired target (e.g., a ligand binding site of a desired target) by utilizing the phage display libraries of the present disclosure. Further embodiments of the present disclosure pertain to peptides that have been screened from the phage display libraries and methods of the present disclosure, such as inhibitors of sirtuin 2, or inhibitors of ENL. |
| FILED | Wednesday, March 04, 2020 |
| APPL NO | 17/436494 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1037 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259590 | Das et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Rhiju Das (Palo Alto, California); Joseph Yesselman (Stanford, California); Kalli Kappel (Stanford, California) |
| ABSTRACT | Systems and methods for generating RNA nanostructures capable of linking RNA structures and capable of securing aptamers in an active and stable structure are disclosed. Generally, RNA possesses many structural properties to create novel nanostructures and machines. RNA tertiary structure is composed of discrete and recurring components known as tertiary ‘motifs’. Along with the helices that they interconnect, many of these structural motifs appear highly modular. Systems and methods herein generate a motif library including canonical and noncanonical motifs to design a candidate path to connect one or more RNA molecules. These paths can also be used to secure RNA aptamers to improve aptamer stability and activity. |
| FILED | Monday, April 20, 2020 |
| APPL NO | 17/594487 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) Original (OR) Class C12N 2310/16 (20130101) C12N 2320/11 (20130101) C12N 2330/31 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 40/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259593 | Weissman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Jonathan Weissman (San Francisco, California); Marco Jost (Berkeley, California); Maximilian A. Horlbeck (Boston, Massachusetts); Daniel Santos (San Francisco, California); Reuben Saunders (San Francisco, California) |
| ABSTRACT | The present disclosure provides methods and compositions for precisely controlling the expression levels of mammalian genes using CRISPRi or CRISPRa and one or more modified sgRNAs. The methods and compositions are useful for, inter alia, titrating the expression of a gene of interest, identifying drug targets and mechanisms of drug resistance, and enabling the analysis of and control over metabolic and signaling pathway fluxes. |
| FILED | Tuesday, January 25, 2022 |
| APPL NO | 17/584176 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/85 (20130101) C12N 15/111 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259596 | Taylor |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hugh Taylor (Easton, Connecticut) |
| ABSTRACT | The invention includes compositions and methods for the treating or preventing endometriosis in a subject in need thereof. In one aspect, the invention relates to compositions and methods for inhibiting microRNA451a. |
| FILED | Friday, July 17, 2020 |
| APPL NO | 17/627927 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/113 (20130101) C12N 2310/122 (20130101) C12N 2310/141 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259597 | Dahlman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Everett Dahlman (Atlanta, Georgia); Cory Dane Sago (Atlanta, Georgia) |
| ABSTRACT | Compositions and methods for inactivating RNA-guided genome editing systems in specific tissue, for example hepatocytes, are provided herein. In one embodiment, the compositions are small chemically modified oligonucleotides that can target and bind to guide RNA, thus eliminating the ability of guide RNA to interact with an endonuclease. The disclosed oligonucleotides are delivered in lipid nanoparticles formulated to target a specific tissue. Subsequently delivered RNA-guided genome editing systems will be inhibited in the specific tissue that received the oligonucleotides. The disclosed compositions and methods allow for reduced RNA-guided genome editing in hepatocytes. |
| FILED | Friday, July 24, 2020 |
| APPL NO | 17/629325 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5123 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/20 (20170501) C12N 2320/31 (20130101) C12N 2320/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259599 | Chan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Ying Kai Chan (Cambridge, Massachusetts); Jessica Chiang (Cambridge, Massachusetts); George M. Church (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein, in some embodiments, are nucleic acid vectors, such as recombinant viral genomes, comprising an inhibitory oligonucleotide that reduces inflammation for use, for example, in gene therapy. |
| FILED | Thursday, May 14, 2020 |
| APPL NO | 17/611062 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 15/117 (20130101) Original (OR) Class C12N 2310/17 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259606 | Coller et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffery M. Coller (Novelty, Ohio); Kristian E. Baker (Novelty, Ohio) |
| ABSTRACT | A synthetic nucleic acid which encodes a protein wherein at least one optimal or non-optimal codon in a wild type nucleic acid encoding the protein has been replaced respectively with one or more non-optimal codons or optimal codons encoding the same amino acid. |
| FILED | Tuesday, February 01, 2022 |
| APPL NO | 17/590071 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/67 (20130101) C12N 15/68 (20130101) Original (OR) Class C12N 15/81 (20130101) C12N 15/85 (20130101) C12N 2800/22 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259616 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sidi Chen (Milford, Connecticut); Matthew Dong (San Francisco, California) |
| ABSTRACT | The present invention includes compositions and methods for T cell genome editing and screening in vivo. In certain aspects, the invention includes an sgRNA library for genome-scale mutagenesis. |
| FILED | Tuesday, April 17, 2018 |
| APPL NO | 16/605715 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 2217/15 (20130101) A01K 2227/101 (20130101) A01K 2227/105 (20130101) A01K 2267/03 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0638 (20130101) C12N 15/85 (20130101) Original (OR) Class C12N 15/111 (20130101) C12N 2310/20 (20170501) C12N 2510/00 (20130101) C12N 2740/16043 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259617 | Joung et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | J. Keith Joung (Winchester, Massachusetts); Peter Cabeceiras (Boston, Massachusetts) |
| ABSTRACT | Human-derived virus-like particles (heVLPs), comprising a membrane comprising a phospholipid bilayer with one or more HERV-derived envelope proteins on the external side; one or more HERV-derived GAG proteins in the heVLP core, and a cargo molecule, e.g., a biomolecule and/or chemical cargo molecule, disposed in the core of the heVLP on the inside of the membrane, wherein the heVLP does not comprise a gag protein, except for gag proteins that are encoded in the human genome or gag proteins that are encoded by a consensus sequence that is derived from gag proteins found in the human genome, and methods of use thereof for delivery of the cargo molecule to cells. |
| FILED | Monday, June 15, 2020 |
| APPL NO | 17/617490 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 2740/10023 (20130101) C12N 2740/10042 (20130101) C12N 2740/10052 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259645 | Jain et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nimit Jain (Redwood City, California); Andrew Z. Fire (Redwood City, California); Lucas R. Blauch (Redwood City, California); Sindy K. Y. Tang (Redwood City, California); Karen L. Artiles (Redwood City, California); Julia T. Garcia-Daou (Redwood City, California); Y. Whitney Yin (Redwood City, California); Michal R. Szymanski (Redwood City, California) |
| ABSTRACT | Compositions and methods for amplifying RNA by replication using transcription polymerases are disclosed. Such replicated RNAs can be used in various applications such as RNAi therapeutics, diagnostic probes, RNA sequencing, directed evolution of RNA aptamers without intermediate conversion to DNA, and RNA vaccines. The transcription polymerases comprise T7 bacteriophage RNA polymerase. |
| FILED | Tuesday, July 07, 2020 |
| APPL NO | 17/624782 |
| CURRENT CPC | Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6853 (20130101) Original (OR) Class Enzymes C12Y 207/07006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259652 | Xie et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaoliang Sunney Xie (Lexington, Massachusetts); Katsuyuki Shiroguchi (Arlington, Massachusetts); Peter A. Sims (Cambridge, Massachusetts); Tony Z. Jia (Cambridge, Massachusetts) |
| ABSTRACT | Methods and compositions for digital profiling of nucleic acid sequences present in a sample are provided. |
| FILED | Wednesday, April 13, 2022 |
| APPL NO | 17/719854 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6853 (20130101) C12Q 1/6874 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259654 | Green et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | University of Massachusetts (Boston, Massachusetts) |
| INVENTOR(S) | Michael R. Green (Boylston, Massachusetts); Sanchita Bhatnagar (Free Union, Virginia) |
| ABSTRACT | In some aspects, the disclosure relates to the reactivation of inactive X chromosomes (Xi). In some embodiments, the disclosure provides compositions and methods for the reactivation of inactive X chromosomes. In some embodiments, the compositions and methods described by the disclosure may be useful for the treatment of dominant X-linked diseases. |
| FILED | Thursday, January 27, 2022 |
| APPL NO | 17/585765 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 2227/10 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) C12Q 2600/178 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5023 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259668 | Vogelstein et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bert Vogelstein (Baltimore, Maryland); Kenneth W. Kinzler (Baltimore, Maryland); Christopher Douville (Baltimore, Maryland); Nickolas Papadopoulos (Towson, Maryland); Cristian Tomasetti (Baltimore, Maryland) |
| ABSTRACT | This document provides methods and materials for identifying chromosomal anomalies that can be used to identify a mammal as having a disease (e.g., cancer or congenital abnormality). For example, this document provides methods and materials for evaluating sequencing data to identify a mammal as having a disease associated with one or more chromosomal anomalies (e.g., cancer or congenital abnormalities). For example, this document provides methods and materials for evaluating sequencing data that can be used in cancer diagnostics, non-invasive prenatal testing (NIPT), preimplantation genetic diagnosis and evaluation of congenital abnormalities. |
| FILED | Friday, May 15, 2020 |
| APPL NO | 17/611788 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/156 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57484 (20130101) G01N 2800/50 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 40/20 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259670 | DASH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (Memphis, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pradyot DASH (Memphis, Tennessee); Paul THOMAS (Memphis, Tennessee) |
| ABSTRACT | A kit and method for analyzing nucleic acid molecules encoding T cell receptor (TCR) a and β from individual T cells are disclosed. In particular, a method for analyzing individual T cells using high-throughput multiplex amplification and deep sequencing of nucleic acids encoding TCRαβ is provided. |
| FILED | Tuesday, June 30, 2020 |
| APPL NO | 17/616279 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259674 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan); Fred Hutchinson Cancer Center (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yuping Zhang (Ann Arbor, Michigan); Marcin Cieslik (Ann Arbor, Michigan); Arul M. Chinnaiyan (Ann Arbor, Michigan); Christopher I. Li (Seattle, Washington) |
| ABSTRACT | Provided herein are compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, provided herein are methods of treating basal-like breast cancer based on expression levels of a panel of cancer markers. |
| FILED | Thursday, February 17, 2022 |
| APPL NO | 17/674121 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) C12Q 1/6886 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220260462 | Volckens et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Colorado State University Research Foundation (Fort Collins, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Volckens (Fort Collins, Colorado); Christian L'Orange (Fort Collins, Colorado); Gabriel Neymark (Golden, Colorado); Ellison Carter (Fort Collins, Colorado) |
| ABSTRACT | Disclosed are methods and systems for implementing an automated air quality analysis system. The system includes: a sealed enclosure, a filter sample analysis system disposed within the sealed enclosure, and a controller operably coupled with the filter sample analysis system. The filter sample analysis system includes: an automated filter management system with filter samples and an articulating robotic arm which selects the filter sample for analysis, a filter weighing apparatus for weighting of the filter sample, and a primary chemical analysis apparatus for performing electromagnetic energy spectroscopy measurement on the filter sample. The controller operates the automated filter management system to transport the filter sample to the filter weighing apparatus and the primary chemical analysis apparatus, obtains data from the filter sample analysis system, and determines the type and amount of accumulated mass in the sample based on the weight and the spectroscopy measurement result. |
| FILED | Friday, February 11, 2022 |
| APPL NO | 17/670204 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/1679 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/2205 (20130101) G01N 1/2273 (20130101) Original (OR) Class G01N 21/3518 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220260520 | Karhanek et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Miloslav Karhanek (Santa Cruz, California); Chris David Webb (Watsonville, California); Senkei Umehara (Tokyo, Japan); Nader Pourmand (San Mateo, California) |
| ABSTRACT | Disclosed are methods and devices for biomolecular detection, comprising a nanopipette, exemplified as a hollow inert, non-biological structure with a conical tip opening of nanoscale dimensions, suitable for holding an electrolyte solution which may contain an analyte such as a protein biomolecule to be detected as it is passed through the tip opening. Biomolecules are detected by specific reaction with peptide ligands chemically immobilized in the vicinity of the tip. Analytes which bind to the ligands cause a detectible change in ionic current. A sensitive detection circuit, using a feedback amplifier circuit, and alternating voltages is further disclosed. Detection of IL-10 at a concentration of 4 ng/ml is also disclosed, as is detection of VEGF. |
| FILED | Tuesday, January 18, 2022 |
| APPL NO | 17/578151 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/42 (20130101) Original (OR) Class G01N 27/4035 (20130101) G01N 33/48707 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220260522 | Xie et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Ping Xie (Needham, Massachusetts); Charles M. Lieber (Lexington, Massachusetts) |
| ABSTRACT | To sense the translocation of a molecule through a nanopore, there is directed to an inlet of the nanopore, having a nanopore fluidic resistance, RP, a molecule disposed in a cis fluidic ionic solution having a cis fluidic access resistance, RC. The molecule is caused to translocate through the nanopore from the inlet of the nanopore to an outlet of the nanopore and to a trans fluidic ionic solution having a trans fluidic access resistance, RT. The trans fluidic access resistance, RT, is of the same order of magnitude as the nanopore fluidic resistance, RP, and both RT and RP are at least an order of magnitude greater than the cis fluidic access resistance, RC. An indication of local electrical potential is produced at a site within the nanopore sensor that is on the trans fluidic ionic solution-side of the nanopore, to sense translocation of the molecule through the nanopore. |
| FILED | Friday, April 29, 2022 |
| APPL NO | 17/732990 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 15/00 (20130101) B82Y 30/00 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/447 (20130101) Original (OR) Class G01N 33/48721 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220260525 | MOLHO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ProteinSimple (San Jose, California) |
| ASSIGNEE(S) | ProteinSimple (San Jose, California) |
| INVENTOR(S) | Joshua I. MOLHO (Oakland, California); Kelly GARDNER (Berkeley, California); Danh C. TRAN (Hayward, California); Eric JABART (Berkeley, California); David NILSON (Walnut Creek, California); Yuri KOUCHNIR (Sunnyvale, California); Michael HUSTON (San Jose, California); Colin B. KENNEDY (Greenbrae, California); David John ROACH (Los Gatos, California) |
| ABSTRACT | A system for assaying a biological sample for a presence of a target analyte includes an assaying device and a computer controller. The assaying device includes a housing, a receptacle disposed in the housing, and a source of activation energy. The receptacle is configured to accept an electrophoresis cell. The electrophoresis cell has a recess area configured to accept a chip configured to accept the biological sample. The chip includes a polymeric separation medium with activatable functional groups that covalently bond to the target analyte when activated. The source of activation energy is configured to supply activation energy to activate the activatable functional groups. The computer controller is operably coupled to the source of activation energy and is configured to activate the source of activation energy to direct an application of activation energy to the polymeric separation medium to activate the activatable functional groups. |
| FILED | Thursday, December 23, 2021 |
| APPL NO | 17/560837 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/44704 (20130101) G01N 27/44726 (20130101) G01N 27/44739 (20130101) G01N 27/44752 (20130101) G01N 27/44756 (20130101) G01N 27/44782 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220260553 | OSTRER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MORGAN AND MENDEL GENOMICS, INC. (New York, New York); ALBERT EINSTEIN COLLEGE OF MEDICINE (Bronx, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Harry OSTRER (New York, New York); Johnny C. LOKE (Valley Cottage, New York); Ishraq ALIM (New York, New York) |
| ABSTRACT | Heritable pathogenic variants in the mismatch repair (MMR) pathway, also known as Lynch Syndrome (LS), can lead to the development of colon cancer and other cancers. Following mismatch, a complex of proteins consisting of MLH1, MSH2, MSH6 and PMS2 translocate into the nucleus to signal recruitment of repair mechanisms. Flow cytometry-based, functional variant assays (FVAs), were developed to determine whether variants in these MMR repair genes and/or other related genes would augment the nuclear translocation of MLH1 and MSH2 and downstream nuclear phosphorylation of ATM and ATR in response to DNA mismatches. Each assay distinguished pathogenic variants in MMR repair genes (MLH1, MSH2, PMS2 and MSH6) from benign controls. The combination of multiple assays provided robust separation between heterozygous pathogenic variant carriers and benign controls. The ability to produce distinct molecular phenotypes by these assays suggest FVA assays of MMR pathways could be used to identify LS and associated risk of colon and other cancers and could act as an adjunct to MMR gene sequencing panels in categorizing variants. |
| FILED | Thursday, February 17, 2022 |
| APPL NO | 17/674400 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/14 (20130101) G01N 33/5023 (20130101) G01N 33/5035 (20130101) G01N 33/5041 (20130101) Original (OR) Class G01N 33/57484 (20130101) G01N 2015/1006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220260565 | Underhill et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CEDARS-SINAI MEDICAL CENTER (Los Angeles, California) |
| ASSIGNEE(S) | CEDARS-SINAI MEDICAL CENTER (Los Angeles, California) |
| INVENTOR(S) | David Underhill (Tarzana, California); Dermot McGovern (Los Angeles, California); Jose Limon (Los Angeles, California); Gil Y. Melmed (Los Angeles, California) |
| ABSTRACT | Described herein are methods of treatment of an inflammatory condition related to fungal immunity. The present disclosure relates to methods and systems for identifying patients suitable for treatment with active agents, as described herein. Further, described herein are various compositions for treating and identifying a subject in need of an active agent for treatment. |
| FILED | Thursday, September 19, 2019 |
| APPL NO | 17/279259 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4196 (20130101) A61K 31/7048 (20130101) A61K 2039/505 (20130101) Peptides C07K 2317/24 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56961 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220260581 | KOZLOV et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Prognosys Biosciences, Inc. (San Diego, California) |
| ASSIGNEE(S) | Prognosys Biosciences, Inc. (San Diego, California) |
| INVENTOR(S) | Igor A. KOZLOV (San Diego, California); Mark S. CHEE (San Diego, California); Petr CAPEK (San Diego, California); David A. ROUTENBERG (San Diego, California) |
| ABSTRACT | The present invention provides methods for constructing peptide construct sets and methods of use of these peptide construct sets in assay systems for peptide analysis, and in particular for use in high throughput peptide analysis. The methods allow for analysis of large sets of peptide constructs in a cost-effective manner, employing molecular biological techniques that are both robust and easily parallelized. Thus, the methods allow for the construction of peptide construct sets encompassing, e.g., the human proteome. |
| FILED | Friday, April 22, 2022 |
| APPL NO | 17/727618 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1062 (20130101) C12N 15/1075 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6803 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220260590 | NEWMAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MOREHOUSE SCHOOL OF MEDICINE (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gale W. NEWMAN (Duluth, Georgia); James W. LILLARD, Jr. (Smyrna, Georgia); Chamberlain OBIALO (Atlanta, Georgia) |
| ABSTRACT | The present application relates to methods of treating HIV-associated nephropathy (HIVAN) and/or focal segmental glomerulosclerosis (FSGS) using endothelin-1 (ET-1) antagonists. The application further relates to a composition for the treatment of HIVAN and/or FSGS. A kit for detecting the presence of ET-1 or ET-1-associated biomarker in a biological sample is also disclosed. |
| FILED | Tuesday, May 10, 2022 |
| APPL NO | 17/662783 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/40 (20130101) A61K 31/422 (20130101) A61K 31/505 (20130101) A61K 31/506 (20130101) A61K 31/4025 (20130101) A61K 38/12 (20130101) A61K 45/06 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/74 (20130101) G01N 33/78 (20130101) G01N 33/6893 (20130101) Original (OR) Class G01N 33/56988 (20130101) G01N 2333/5754 (20130101) G01N 2800/28 (20130101) G01N 2800/52 (20130101) G01N 2800/347 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220260591 | KORONYO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CEDARS-SINAI MEDICAL CENTER (Los Angeles, California) |
| ASSIGNEE(S) | CEDARS-SINAI MEDICAL CENTER (Los Angeles, California) |
| INVENTOR(S) | Maya KORONYO (Los Angeles, California); Haoshen SHI (Los Angeles, California); Yosef KORONYO (Los Angeles, California); Keith L. BLACK (Los Angeles, California) |
| ABSTRACT | The present invention describes a method for the detection, diagnosis and monitoring of cognitive impairment and Alzheimer's disease. The method involves the detection of pericyte loss and deficiency in PDGFRβ, alone or in combination with retinal vascular Aβ deposits. The method also involves detecting an alteration in blood-retinal barrier (BRB) cell tight junction. |
| FILED | Thursday, February 03, 2022 |
| APPL NO | 17/592433 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/12 (20130101) A61B 3/0025 (20130101) A61B 3/102 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) Original (OR) Class G01N 2800/2821 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220260593 | Sierks et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Michael Sierks (Ft. McDowell, Arizona); Stephanie Williams (Phoenix, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Sierks (Ft. McDowell, Arizona); Stephanie Williams (Phoenix, Arizona) |
| ABSTRACT | Disclosed herein are antibodies, antibody fragments, binding agents, and compositions that specifically recognize protein variant biomarkers associated with frontotemporal dementia, kits and methods of use, including diagnosing, monitoring and treating frontotemporal dementia. |
| FILED | Friday, June 12, 2020 |
| APPL NO | 17/618869 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/53 (20130101) G01N 33/6896 (20130101) Original (OR) Class G01N 2333/4709 (20130101) G01N 2800/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220260596 | Gurkan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Umut Gurkan (Cleveland, Ohio); Ran An (Cleveland, Ohio) |
| ABSTRACT | A diagnostic system detects and/or measures hemoglobin and/or hemoglobin variants in blood of subject to determine hemoglobin levels, hemoglobin variants, and/or anemia in the subject. |
| FILED | Monday, June 29, 2020 |
| APPL NO | 17/622062 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/721 (20130101) Original (OR) Class G01N 33/726 (20130101) G01N 2001/4038 (20130101) G01N 2800/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220260655 | Conolly et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California); University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| INVENTOR(S) | Steven Conolly (Walnut Creek, California); Carlos Rinaldi (Gainesville, Florida); Bo Zheng (Seattle, Washington); Prashant Chandrasekharan (Berkeley, California); Daniel Hensley (Emeryville, California); Shehaab Savliwala (Gainesville, California); Zhi Wei Tay (Singapore, Singapore); Rohan Deepak Dhavalikar (Hillsboro, Oregon) |
| ABSTRACT | A magnetic particle imaging system that includes a magnetic field generating system with at least one magnet and providing a gradient magnetic field within an observation region such that the gradient magnetic field has a dynamic field-free region (FFR) for an object under observation having strongly-interacting magnetic particles distributed therein. The magnetic field generating system also includes a drive field and a slow shift field that dynamically shifts the FFR across a field of view (FOV) within the observation region, where the trajectory of the drive field accommodates for a coercivity of the strongly-interacting magnetic particles by ensuring that the particles in the FOV are saturated to a full coercivity field prior to traversing to an opposite-polarity of coercivity. The magnetic particle imaging system also includes a detection system proximate the observation region and configured to detect a signal from the strongly-interacting magnetic particles. The magnetic particle imaging system further includes signal processor in communication with the detection system, configured to receive and process the detected signal to remove a coercivity shift due to the coercivity of the strongly-interacting magnetic particles, and convert the processed detection signal into an image of the strongly-interacting magnetic particles. |
| FILED | Thursday, July 23, 2020 |
| APPL NO | 17/629301 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0515 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/1276 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220260661 | Rispoli et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Joseph V. Rispoli (West Lafayette, Indiana); Xin Li (Saint Anthony, Minnesota) |
| ABSTRACT | A method of operating a multi-coil magnetic resonance imaging system, is disclosed which includes establishing initial circuit values of a drive circuit, loading a tissue model associated with a tissue to be imaged, loading target values for a variable of interest (VOI) associated with operation of two or more coils of a magnetic resonance imaging system, performing a simulation based on the established circuit values and the loaded tissue model, determining output values of the VOI based on the simulation, comparing the simulated output values of the VOI to the loaded target values of the VOI, if the simulated output values are outside of a predetermined envelope about the loaded target values of the VOI, then performing a first optimization until the simulated output values are within the predetermined envelope. |
| FILED | Tuesday, February 08, 2022 |
| APPL NO | 17/667480 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/288 (20130101) G01R 33/543 (20130101) G01R 33/3415 (20130101) G01R 33/5659 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220260821 | Glaser et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Adam K. Glaser (Seattle, Washington); Jonathan T.C. Liu (Seattle, Washington) |
| ABSTRACT | Apparatuses, systems, and methods for an open-top light-sheet (OTLS) microscope which includes an illumination objective and a collection objective which have optical axes which are non-orthogonal to each other. The optical axis of the collection objective may be orthogonal to a plane of the sample holder. The illumination and collection objective may be located below the sample holder. The OTLS microscope may optionally include a second collection objective which has an optical axis orthogonal to the optical axis of the illumination objective. The illumination objective may be an air objective, and the collection objective may be an immersion objective. |
| FILED | Thursday, May 05, 2022 |
| APPL NO | 17/737736 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 21/02 (20130101) G02B 21/06 (20130101) Original (OR) Class G02B 21/33 (20130101) G02B 21/361 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220261662 | Chandrasekar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (Blacksburg, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Prashant Chandrasekar (Natick, Massachusetts); Edward A. Fox (Blacksburg, Virginia) |
| ABSTRACT | The present disclosure describes various embodiments of extensible information systems and methods. One such system comprises a user interface configured to receive a query that includes a description of a research goal of a user; a reasoner configured to receive data from the user interface related to a user goal and generate a description of a workflow that will address the user goal, based on information in a knowledge graph and a services registry; and a workflow manager configured to receive a workflow description from the reasoner and manage an execution of workflows by scheduling for execution one or more services that are identified in the knowledge graph and described in the services registry. Other systems and methods are also provided. |
| FILED | Wednesday, February 16, 2022 |
| APPL NO | 17/673242 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/9024 (20190101) G06F 40/211 (20200101) Computer Systems Based on Specific Computational Models G06N 5/022 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220261987 | Gurcan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Metin Gurcan (Winston-Salem, North Carolina); Aaron Moberly (Columbus, Ohio) |
| ABSTRACT | Disclosed herein are systems and methods to detect a wide range of eardrum abnormalities by using high-resolution otoscope images of both a left eardrum and a right eardrum of a subject and report the condition of each of the eardrums as “normal” or “abnormal.” |
| FILED | Wednesday, December 08, 2021 |
| APPL NO | 17/545691 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/227 (20130101) A61B 5/12 (20130101) A61B 5/1032 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 2207/10016 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/20212 (20130101) Image or Video Recognition or Understanding G06V 10/40 (20220101) G06V 10/82 (20220101) G06V 10/764 (20220101) G06V 10/806 (20220101) G06V 2201/03 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220261996 | Mascharak et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Shamik Mascharak (Santa Cruz, California); Heather E. desJardins-Park (Menlo Park, California); Mimi Borrelli (Stanford, California); Alessandra Laura Moore (Stanford, California); Michael T. Longaker (Stanford, California) |
| ABSTRACT | A system and method for analyzing a plurality of tissue image samples at different stages of image processing in order to establish the level of fibrosis within a patient from which the tissue image sample was retrieved. Various embodiments incorporate machine learning techniques which enable an automated progressive approach to effectively and efficiently diagnosing fibrotic conditions based on tissue image samples. |
| FILED | Monday, July 27, 2020 |
| APPL NO | 17/597833 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/444 (20130101) Image Data Processing or Generation, in General G06T 5/002 (20130101) G06T 7/13 (20170101) G06T 7/0014 (20130101) Original (OR) Class G06T 7/90 (20170101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101) G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220262105 | Zhou et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Zongwei ZHOU (Tempe, Arizona); Vatsal SODHA (Tempe, Arizona); Md, Mahfuzur RAHMAN SIDDIQUEE (Tempe, Arizona); Ruibin FENG (Scottsdale, Arizona); Nima TAJBAKHSH (Los Angeles, California); Jianming LIANG (Scottsdale, Arizona); Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zongwei Zhou (Tempe, Arizona); Vatsal Sodha (San Jose, California); Md Mahfuzur Rahman Siddiquee (Tempe, Arizona); Ruibin Feng (Scottsdale, Arizona); Nima Tajbakhsh (Los Angeles, California); Jianming Liang (Scottsdale, Arizona) |
| ABSTRACT | Described herein are means for generating source models for transfer learning to application specific models used in the processing of medical imaging. In some embodiments, the method comprises: identifying a group of training samples, wherein each training sample in the group of training samples includes an image; for each training sample in the group of training samples: identifying an original patch of the image corresponding to the training sample; identifying one or more transformations to be applied to the original patch; generating a transformed patch by applying the one or more transformations to the identified patch; and training an encoder-decoder network using a group of transformed patches corresponding to the group of training samples, wherein the encoder-decoder network is trained to generate an approximation of the original patch from a corresponding transformed patch, and wherein the encoder-decoder network is trained to minimize a loss function that indicates a difference between the generated approximation of the original patch and the original patch. The source models significantly enhance the transfer learning performance for many medical imaging tasks including, but not limited to, disease/organ detection, classification, and segmentation. Other related embodiments are disclosed. |
| FILED | Friday, July 17, 2020 |
| APPL NO | 17/625313 |
| CURRENT CPC | Image or Video Recognition or Understanding G06V 10/82 (20220101) G06V 10/98 (20220101) G06V 10/776 (20220101) G06V 10/7747 (20220101) Original (OR) Class G06V 2201/03 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220262462 | Peters et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Gerard Peters (Pittsburgh, Pennsylvania); Tianjiao Chu (Pittsburgh, Pennsylvania); Lisa Ann Pan (Pittsburgh, Pennsylvania); David N. Finegold (Pittsburgh, Pennsylvania) |
| ABSTRACT | Computational techniques are disclosed for using methylation profiles to classify the medication condition of a person. Initial sequence data is obtained containing sequences of an initial set of nucleic acids from a biological sample of a person. The initial sequence data is filtered to generate filtered sequence data that describes sequences of a filtered subset of nucleic acids from the biological sample. A methylation profile is determined for the filtered subset of nucleic acids from the biological sample. The methylation profile can be processed to determine a likelihood that the person has the specified medical condition. The system outputs an indication of the likelihood that the person has the specified medical condition. |
| FILED | Friday, April 10, 2020 |
| APPL NO | 17/602553 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) G16B 20/00 (20190201) G16B 30/00 (20190201) G16B 40/20 (20190201) Original (OR) Class G16B 50/20 (20190201) G16B 50/30 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/40 (20180101) G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220262496 | Akbari et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yama Akbari (Irvine, California); Matine Azadian (Irvine, California); Robert H. Wilson (Irvine, California) |
| ABSTRACT | Systems and methods for generating neuroprotective and cardioprotective nutrition programs are described herein. These neuroprotective and cardioprotective nutrition programs are especially applicable for patients at risk of cardiac arrest (e.g. due to hypoxia or ischemia of the brain or other body parts). The programs may feature caloric restriction, for example, short-term caloric restriction. The programs may be generated or iteratively modified based on the hemodynamic and metabolic state of the patient's brain, limbs, or other tissues or organs. Dynamic feedback about the patient's hemodynamic and metabolic state may be provided by techniques including, but not limited to, optical technology for quantitatively and noninvasively measuring blood flow, oxygenation, metabolic rate of oxygen, and perfusion/metabolism ratio in the brain, limbs, or other tissues or organs. The systems described herein may also induce spreading depolarization and repolarization at specific times during or after cardiac arrest based on the patient's cerebral metabolic state. |
| FILED | Tuesday, May 03, 2022 |
| APPL NO | 17/735903 |
| CURRENT CPC | Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/60 (20180101) Original (OR) Class G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20220257126 | Hsu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Yu-Pin Hsu (Troy, New York); Zemin Liu (Troy, New York); Mona Mostafa Hella (Watervliet, New York) |
| ASSIGNEE(S) | RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York) |
| INVENTOR(S) | Yu-Pin Hsu (Troy, New York); Zemin Liu (Troy, New York); Mona Mostafa Hella (Watervliet, New York) |
| ABSTRACT | One embodiment provides an offset calibration circuitry configured to compensate an offset voltage of a resistive bridge sensor. The offset calibration circuitry includes a first current digital to analog converter (IDAC) coupled to a first successive approximation register (SAR), a second IDAC coupled to a second SAR and an SAR controller circuitry. The first IDAC is configured to couple to a negative voltage port of a resistive bridge sensor. The first SAR is configured to store a circuitry first digital value. The second IDAC is configured to couple to a positive voltage port of the resistive bridge sensor. The second SAR is configured to store a second digital value. The SAR controller circuitry is configured to adjust each bit of the first SAR and each bit of the second SAR based, at least in part, on an output of a comparator. The comparator is configured to compare a voltage on the negative voltage port or a voltage on the positive voltage port to a common mode voltage. |
| FILED | Friday, June 26, 2020 |
| APPL NO | 17/622280 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/02108 (20130101) Original (OR) Class A61B 5/6802 (20130101) A61B 5/7225 (20130101) A61B 2560/0252 (20130101) A61B 2560/0257 (20130101) A61B 2560/0261 (20130101) Coding; Decoding; Code Conversion in General H03M 1/466 (20130101) H03M 1/1023 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257266 | Brody et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland); The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland); The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | David L. Brody (Bethesda, Maryland); David Blodgett (Ellicott City, Maryland); Carissa Rodriguez (Laurel, Maryland); Timothy Sleasman (Silver Spring, Maryland); Michael J. Fitch (Catonsville, Maryland); Adam Cohen (Baltimore, Maryland); Max R. Basescu (Baltimore, Maryland); Kevin C. Wolfe (Lutherville, Maryland); Jared M. Wormley (Silver Spring, Maryland) |
| ABSTRACT | An intracranial access device includes a housing having an operator-facing side and a patient-facing side and an opening therethrough extending from the operator-facing side to the patient-facing side. The device further includes at least one fastener configured to secure the device to a cranium of a patient. The device further includes a drill mounted to a surface of the housing and a cauterizer. The device may further include a number of sensors arranged on the patient-facing side of the housing and configured to identify a hemorrhage location. |
| FILED | Thursday, July 16, 2020 |
| APPL NO | 17/627567 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/031 (20130101) A61B 17/1695 (20130101) Original (OR) Class A61B 17/1739 (20130101) A61B 18/1402 (20130101) A61B 90/11 (20160201) A61B 2018/00321 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0539 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257389 | Herr et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hugh M. Herr (Concord, New Hampshire); Roman Stolyarov (Britsol, Rhode Island); Luke M. Mooney (Westford, Massachusetts); Cameron Taylor (Wayzata, Minnesota); Matthew Carney (Somerville, Massachusetts) |
| ABSTRACT | An autonomous wearable leg device employs an array of sensors embedded along a support area, whereby a controller can generate a controlling command and send a controlling command to a prosthetic, orthotic, exoskeletal or wearable component to thereby control the prosthetic, orthotic, exoskeletal or wearable component. A method for controlling autonomous wearable device collects kinetic signals from an array of sensors embedded in a prosthetic, orthotic or exoskeletal component, wherein all values are extracted from at least one feature of the collected kinetic signals, which are applied to a controller that generates a controlling command that is sent to the prosthetic, orthotic exoskeletal component to thereby control the prosthetic, orthotic or exoskeletal component during a portion of a gait cycle. |
| FILED | Thursday, January 06, 2022 |
| APPL NO | 17/647320 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/112 (20130101) A61B 5/4851 (20130101) A61B 5/6807 (20130101) A61B 5/7275 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/60 (20130101) A61F 2/64 (20130101) A61F 2/66 (20130101) A61F 2/68 (20130101) A61F 2/70 (20130101) Original (OR) Class A61F 2/6607 (20130101) A61F 5/0102 (20130101) A61F 2002/5009 (20130101) Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 3/00 (20130101) Manipulators; Chambers Provided With Manipulation Devices B25J 9/0006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257445 | Portoghese et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America as represented by the Secretary of the Navy (Patuxent River, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rocco Portoghese (Winter Park, Florida); Matthew Adams (Orlando, Florida); Tyson Griffin (Oviedo, Florida); Nelson Lerma (Orlando, Florida); Chad Farwig (Oviedo, Florida) |
| ABSTRACT | A normobaric hypoxia trainer including a training chamber, an intake fan for allowing ground level air to be introduced into the training chamber; an exhaust fan for removing air from the training chamber; a plurality of circulation fans for mixing interior air of the training chamber to create a uniform oxygen concentration within the training chamber; a nitrogen generation system, the nitrogen generating system including a plurality of polysulphone membrane cartridges for separating out nitrogen from air; a compressor for supplying compressed air to the nitrogen generation system; a pressure regulator for regulating the pressure of the compressed air; a heater for controlling temperature of the compressed air, the heated pressure regulated compressed air passing through the polysulphone membrane cartridges such that nitrogen can be separated out from the air; and, a flow controller for controlling flow rate of the separated nitrogen into the training chamber. |
| FILED | Tuesday, February 16, 2021 |
| APPL NO | 17/176467 |
| CURRENT CPC | Transport, Personal Conveyances, or Accommodation Specially Adapted for Patients or Disabled Persons; Operating Tables or Chairs; Chairs for Dentistry; Funeral Devices A61G 10/02 (20130101) Original (OR) Class Apparatus for Physical Training, Gymnastics, Swimming, Climbing, or Fencing; Ball Games; Training Equipment A63B 23/18 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 9/085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257553 | Nag et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Okhil Nag (Alexandria, Virginia); D. Andrew Knight (New Orleans, Louisiana); James B. Delehanty (Washington, District of Columbia) |
| ABSTRACT | A cobalt-loaded porphyrin complex, comprising the porphyrin (meso-tri(4-sulfonatophenyl) mono(4-carboxyphenyl)porphine (C1S3TPP)) with coordinated with cobalt, effectively neutralizes the biological activity of opioids. |
| FILED | Tuesday, February 22, 2022 |
| APPL NO | 17/676931 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/14 (20130101) A61K 31/28 (20130101) Original (OR) Class A61K 47/6929 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/36 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257612 | Kaddurah-Daouk et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rima F. KADDURAH-DAOUK (Durham, North Carolina); Siamak MAHMOUDIANDEHKORDI (Durham, North Carolina); Cornelia VAN DUIJIN (Oxford, United Kingdom); Shahzad AHMAD (Rotterdam, Netherlands); Andrew J. SAYKIN (Indianapolis, Indiana); Kwangsik NHO (Indianapolis, Indiana); Rebecca BAILLIE (San Carlos, California); Xianlin HAN (San Antonio, Texas); DUKE UNIVERSITY (Durham, North Carolina); OXFORD UNIVERSITY (Oxford,, United Kingdom); ERASMUS MEDICAL CENTER (Rotterdam, Netherlands); INDIANA UNIVERSITY SCHOOL OF MEDICINE (Indianapolis, Indiana); UNIVERSITY OF TEXAS (San Antonio, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rima F. Kaddurah-Daouk (Belmont, Massachusetts); Siamak Mahmoudiandehkordi (Durham, North Carolina); Cornelia van Duijin (Oxford, United Kingdom); Shahzad Ahmad (Rotterdam, Netherlands); Andrew J. Saykin (Indianapolis, Indiana); Kwangsik Nho (Indianapolis, Indiana); Rebecca Baillie (San Carlos, California); Xianlin Han (San Antonio, Texas) |
| ABSTRACT | Described herein are methods for identifying or diagnosing Alzheimer's disease or poor cognition in a subject or population of subjects by analyzing biomarkers. In one aspect, the biomarkers comprise liver function enzymes or metabolites including alanine aminotransferase (ALT), aspartate aminotransferase (AST), ratio of ALT to AST, alkaline phosphatase, albumin, bilirubin, cholesterol and cholesterol metabolites, amino acids, phospholipids, bile acids, or other metabolites. In another aspect, the biomarkers comprise alanine aminotransferase (ALT), aspartate aminotransferase (AST), or the ratio of ALT to AST levels. In another aspect, the marker comprises the genotype of the ALT or AST enzymes. |
| FILED | Friday, July 24, 2020 |
| APPL NO | 17/625046 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/07 (20130101) A61K 31/13 (20130101) A61K 31/27 (20130101) A61K 31/40 (20130101) A61K 31/55 (20130101) A61K 31/60 (20130101) A61K 31/167 (20130101) A61K 31/192 (20130101) A61K 31/196 (20130101) A61K 31/216 (20130101) A61K 31/355 (20130101) A61K 31/366 (20130101) A61K 31/427 (20130101) A61K 31/445 (20130101) A61K 31/475 (20130101) A61K 31/496 (20130101) A61K 31/505 (20130101) A61K 31/506 (20130101) A61K 31/575 (20130101) Original (OR) Class A61K 31/635 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257632 | Cheung et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Fred Hutchinson Cancer Research Center (Seattle, Washington) |
| ASSIGNEE(S) | Fred Hutchinson Cancer Research Center (Seattle, Washington) |
| INVENTOR(S) | Kevin J. Cheung (Seattle, Washington); Emma D. Wrenn (Seattle, Washington) |
| ABSTRACT | The disclosure provides methods and compositions for microlumen targeting in the treatment of cancers characterized by solid tumors or cell clusters, such as circulating tumor cell (CTC) clusters and disseminated tumor cell (DTC) clusters. The methods and compositions specifically target epigen in microlumenal space between two or more cancer cells and reduce the expression, functionality and/or concentration of epigen within the microlumenal space. The methods and compositions can be part of methods of treating cancer in a subject wherein the cancer is characterized by a solid tumor, a circulating tumor cell (CTC) cluster, and/or a disseminated tumor cell (DTC) cluster. The reduced levels of functional epigen in the microlumen result in reduced incidence of metastasis and increased susceptibility of the tumor cells to additional therapeutic interventions. |
| FILED | Friday, June 19, 2020 |
| APPL NO | 17/619403 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/198 (20130101) A61K 31/7088 (20130101) Original (OR) Class A61K 38/217 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) Peptides C07K 16/22 (20130101) C07K 2317/76 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57488 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257701 | JOHNSTON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen Albert JOHNSTON (Tempe, Arizona); Luhui SHEN (Tempe, Arizona) |
| ABSTRACT | Provided herein, are methods of identifying neoantigens for treating and preventing cancer. Also disclosed are methods and compositions for administering identified neoantigens for the treatment and prevention of cancer. |
| FILED | Friday, April 01, 2022 |
| APPL NO | 17/711849 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/08 (20130101) A61K 38/10 (20130101) A61K 38/16 (20130101) Original (OR) Class A61K 39/0011 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1093 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57488 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257742 | EAPPEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sanaria Inc. (Rockville, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Abraham G. EAPPEN (Ellicott City, Maryland); Stephen L. HOFFMAN (Gaithersburg, Maryland) |
| ABSTRACT | The application is directed to in vitro-reared Plasmodium sporozoites of human host range wherein sporogony from gametocyte stage to sporozoite stage is external to mosquitoes, and methods of producing the same. Provided herein are in vitro-reared infectious Plasmodium sporozoites (SPZ) of human host range, particularly P. falciparum, P. vivax, P. ovale, P. malariae, and P. knowlesi, wherein sporogony from gametocyte stage to sporozoite stage is external to mosquitoes, and methods of producing the same. |
| FILED | Thursday, November 18, 2021 |
| APPL NO | 17/529812 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/015 (20130101) Original (OR) Class A61K 2039/52 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257760 | Cripe et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL (Columbus, Ohio) |
| ASSIGNEE(S) | RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL (Columbus, Ohio) |
| INVENTOR(S) | Timothy P. Cripe (Columbus, Ohio); Chun-yu Chen (Columbus, Ohio); Brian Hutzen (Columbus, Ohio); Mark Currier (Columbus, Ohio); Pin-yi Wang (Columbus, Ohio); Dawn Chandler (Columbus, Ohio) |
| ABSTRACT | Recombinant polynucleotides and vectors containing an engineered (artificial) exon-intron-exon gene structure in a transgene are provided, which undergoes splicing when it is expressed in a target cell. |
| FILED | Wednesday, February 19, 2020 |
| APPL NO | 17/432398 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7105 (20130101) A61K 39/39558 (20130101) Original (OR) Class A61K 48/005 (20130101) A61K 2039/5258 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/32 (20130101) C07K 2317/31 (20130101) C07K 2317/622 (20130101) C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/62 (20130101) C12N 15/86 (20130101) C12N 15/1138 (20130101) C12N 2310/11 (20130101) C12N 2710/16033 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220258125 | McGill et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | R. Andrew McGill (Lorton, Virginia); Courtney A. Roberts (Washington, District of Columbia) |
| ABSTRACT | The invention relates to strong hydrogen-bond acidic sorbents. The sorbents may be provided in a form that limits or eliminates intramolecular bonding of the hydrogen-bond acidic site between neighboring sorbent molecules, for example, by providing steric groups adjacent to the hydrogen-bond acidic site. The hydrogen bond site may be a phenolic structure based on a bisphenol architecture. The sorbents of the invention may be used in methods for trapping or detecting hazardous chemicals or explosives. |
| FILED | Thursday, April 21, 2022 |
| APPL NO | 17/725794 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/22 (20130101) Original (OR) Class B01J 20/282 (20130101) B01J 20/3425 (20130101) B01J 20/3483 (20130101) B01J 20/28023 (20130101) B01J 2220/54 (20130101) Acyclic or Carbocyclic Compounds C07C 39/367 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 14/06 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 59/00 (20130101) C08G 64/00 (20130101) C08G 64/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220258126 | McGill et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretaryof the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | R. Andrew McGill (Lorton, Virginia); Courtney A. Roberts (Washington, District of Columbia) |
| ABSTRACT | The invention relates to strong hydrogen-bond acidic sorbents. The sorbents may be provided in a form that limits or eliminates intramolecular bonding of the hydrogen-bond acidic site between neighboring sorbent molecules, for example, by providing steric groups adjacent to the hydrogen-bond acidic site. The hydrogen bond site may be a phenolic structure based on a bisphenol architecture. The sorbents of the invention may be used in methods for trapping or detecting hazardous chemicals or explosives. |
| FILED | Thursday, April 21, 2022 |
| APPL NO | 17/725840 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/22 (20130101) Original (OR) Class B01J 20/282 (20130101) B01J 20/3425 (20130101) B01J 20/3483 (20130101) B01J 20/28023 (20130101) B01J 2220/54 (20130101) Acyclic or Carbocyclic Compounds C07C 39/367 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 14/06 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 59/00 (20130101) C08G 64/00 (20130101) C08G 64/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220258244 | Benedict et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | Raytheon Company (Waltham, Massachusetts) |
| INVENTOR(S) | James Benedict (Andover, Massachusetts); Raquel M. Doyen (Marlborough, Massachusetts); Brian J. Duffy (Marlborough, Massachusetts); Judith E. Gill (Dallas, Texas); Erica Klek (Wilmington, Massachusetts); Jacob Steinberg (Dallas, Texas) |
| ABSTRACT | A method of making a waveguide for a radar system includes forming an additive manufacturing build of a waveguide by forming an initial layer, followed by forming a succession of build layers on the initial layer in a build direction from the initial layer towards a final layer. Forming the succession of build layers includes forming an overhanging feature supported by a support formed in the succession of build layers. |
| FILED | Monday, February 15, 2021 |
| APPL NO | 17/176115 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/28 (20210101) B22F 10/47 (20210101) Original (OR) Class B22F 2301/052 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 40/20 (20200101) B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220258309 | LYNCH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DANIEL LYNCH (New Bern, North Carolina); TIMOTHY WETHERINGTON (Havelock, North Carolina) |
| ASSIGNEE(S) | United States of America as represented by the Secretary of the Navy (Patuxent River, Maryland) |
| INVENTOR(S) | DANIEL LYNCH (New Bern, North Carolina); TIMOTHY WETHERINGTON (Havelock, North Carolina) |
| ABSTRACT | The spindle area tube removal and installation tool includes an outer tube assembly; an inner tube assembly disposed within the outer tube assembly, the inner tube assembly having a first end and a second end; a handle assembly attached to the first end of inner tube assembly such that when the handle assembly is rotated the inner tube assembly rotates; a head assembly for gripping clamps within the spindle area; a gear assembly communicating with the head assembly, the gear assembly attached to the second end of the inner tube assembly such that when the inner tube assembly rotates the gear assembly provides a ninety degree power transfer to the head assembly, such that the head assembly rotates the clamps within the spindle area 360 degrees, allowing removal of the spindle area tube. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/174523 |
| CURRENT CPC | Tools or Bench Devices Not Otherwise Provided For, for Fastening, Connecting, Disengaging or Holding B25B 13/481 (20130101) Original (OR) Class B25B 17/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220258841 | Hooper et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America as represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ralph David Hooper (Lemon Grove, California); Jeffery Towns Gilchrist (Cardiff, California); William A. Chambers (Jamul, California); Taylor R. Doolittle (San Diego, California) |
| ABSTRACT | An apparatus and method transports, launches, and recovers an unmanned undersea vehicle (UUV) on a boat. A pair of support rails secures the UUV to the boat during the transport across a body of water on the boat. The support rails support the UUV in sliding movement along the support rails during the launch from the boat into the body of water and during the recovery from the body of water onto the boat. A ramp is deployed that extends the support rails into the body of water through a stern of the boat. The ramp includes a pair of alignment rails for aligning the UUV with the support rails during the recovery. A winch pulls the UUV out of the body of water during the recovery, with the winch pulling the UUV into the alignment rails and then onto the support rails in the boat. |
| FILED | Thursday, February 18, 2021 |
| APPL NO | 17/178694 |
| CURRENT CPC | Ships or Other Waterborne Vessels; Equipment for Shipping B63B 27/08 (20130101) B63B 27/143 (20130101) B63B 35/42 (20130101) Original (OR) Class B63B 2035/405 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259118 | Little et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright -Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian K. Little (Niceville, Florida); Dylan K. Smith (Fort Walton Beach, Florida); Christopher A. Crouse (Valparaiso, Florida); Dylan T. Slizewski (Colorado Springs, Colorado) |
| ABSTRACT | A method of making RDX nanoparticles comprises dissolving RDX in acetone; injecting the RDX/acetone through an inner tube of a turbulent mixer to form an inner flow; injecting an anti-solvent through an outer tube of a turbulent mixer to form an outer flow, wherein the inner tube is concentric with the outer tube, wherein turbulent mixing of the inner flow and outer flow precipitates nanoparticle of RDX. The concentration of RDX in acetone may be 0.5-1.0 mg RDX/mL acetone. The anti-solvent is a mixture of hexane and cyclohexanone. |
| FILED | Tuesday, November 30, 2021 |
| APPL NO | 17/456915 |
| CURRENT CPC | Explosives or Thermic Compositions; Manufacture Thereof; Use of Single Substances as Explosives C06B 21/0008 (20130101) Original (OR) Class C06B 25/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259149 | Wipf et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter Wipf (Pittsburgh, Pennsylvania); Taber Sarah Maskrey (Pittsburgh, Pennsylvania); Matthew G. LaPorte (Seven Fields, Pennsylvania); Manwika Charaschanya (San Diego, California) |
| ABSTRACT | Provided herein are compounds useful in the prevention or treatment of ferroptosis in a patient, and methods of preventing or treating ferroptosis, or a treating a condition or disease associated with ferroptosis, such as a patient having a neurodegenerative disease, traumatic brain injury, acute kidney disease, liver injury, ischemia/reperfusion injury, ischemic stroke, intracerebral hemorrhage, liver fibrosis, diabetes, acute myeloid leukemia, age-related macular degeneration, psoriasis, a hemolytic disorder, or an inflammatory disease. |
| FILED | Monday, July 27, 2020 |
| APPL NO | 17/629960 |
| CURRENT CPC | Heterocyclic Compounds C07D 211/94 (20130101) Original (OR) Class C07D 405/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259220 | Sadler et al. |
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| FUNDED BY |
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| APPLICANT(S) | DREXEL UNIVERSITY (Philadelphia, Pennsylvania); The Government of the United States of America as Represented by the Secretary of the Army (Adelphi, Maryland) |
| ASSIGNEE(S) | DREXEL UNIVERSITY (Philadelphia, Pennsylvania); The Government of the United States of America as Represented by the Secretary of the Army (Adelphi, Maryland) |
| INVENTOR(S) | Joshua Matthew Sadler (Middle River, Maryland); John Joseph La Scala (Wilmington, Delaware); Giuseppe R. Palmese (Hainesport, New Jersey) |
| ABSTRACT | This invention outlines a method for synthesizing a blended resin system in a one pot reaction that may utilize, for example, bio-based anhydrosugars such as isosorbide as a principle component to produce isosorbide dimethacrylate and other monomeric materials for thermosetting applications. This invention establishes a one-pot procedure for reacting a hydroxy group containing compound with methacrylic anhydride in the first step and using the by-product methacrylic acid to react with glycidyl ethers to form additional methacrylate compounds in the second step. This methodology can be formulated to produce a wide array of resin systems that have controlled ratios of hydroxy group containing compound/cross-linker/reactive diluent. Additionally, the novel resin systems may be partially to fully bio-based, promoting global sustainability and reducing costs, and when free radically polymerized have properties that meet or exceed their petroleum derived counterparts. |
| FILED | Thursday, November 18, 2021 |
| APPL NO | 17/530089 |
| CURRENT CPC | Heterocyclic Compounds C07D 493/04 (20130101) Original (OR) Class Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 59/42 (20130101) C08G 59/1466 (20130101) C08G 59/4238 (20130101) Compositions of Macromolecular Compounds C08L 33/08 (20130101) C08L 63/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259412 | HU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Liangbing HU (Potomac, Maryland); Mingwei ZHU (Nanjing, China PRC); Tian LI (West Lafayette, Indiana); Amy S. GONG (Potomac, Maryland); Jianwei SONG (College Park, Maryland) |
| ABSTRACT | Highly transparent (up to 92% light transmittance) wood composites have been developed. The process of fabricating the transparent wood composites includes lignin removal followed by index-matching polymer infiltration resulted in fabrication of the transparent wood composites with preserved naturally aligned nanoscale fibers. The thickness of the transparent wood composite can be tailored by controlling the thickness of the initial wood substrate. The optical transmittance can be tailored by selecting infiltrating polymers with different refractive indices. The transparent wood composites have a range of applications in biodegradable electronics, optoelectronics, as well as structural and energy efficient building materials. By coating the transparent wood composite layer on the surface of GaAs thin film solar cell, an 18% enhancement in the overall energy conversion efficiency has been attained. |
| FILED | Monday, May 02, 2022 |
| APPL NO | 17/734283 |
| CURRENT CPC | Processes, Apparatus or Selection of Substances for Impregnating, Staining, Dyeing, Bleaching of Wood or Similar Materials, or Treating of Wood or Similar Materials With Permeant Liquids, Not Otherwise Provided for; Chemical or Physical Treatment of Cork, Cane, Reed, Straw or Similar Materials B27K 3/15 (20130101) B27K 3/0207 (20130101) B27K 2240/10 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 9/26 (20130101) C08J 9/42 (20130101) C08J 2201/0422 (20130101) C08J 2301/02 (20130101) Compositions of Macromolecular Compounds C08L 1/02 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/184 (20130101) H01L 31/0304 (20130101) H01L 31/02168 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259463 | Zhao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xuanhe Zhao (Allston, Massachusetts); Hyunwoo Yuk (Cambridge, Massachusetts); Heejung Roh (Cambridge, Massachusetts) |
| ABSTRACT | A dry shape memory adhesive material for adhering a target surface in the presence of fluid and for providing tunable mechanical contraction of an adhered surface. The dry shape memory adhesive material is pre-stretched and dried to provide an adhesive structure that implements a hydration-based shape memory mechanism to achieve both uniaxial and biaxial contractions of the adhered surface. According to preferred embodiments, the shape memory adhesive material includes a combination of one or more hydrophilic polymers or copolymers, one or more amine coupling group, and one or more cross linkers. |
| FILED | Tuesday, February 08, 2022 |
| APPL NO | 17/666642 |
| CURRENT CPC | Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 7/25 (20180101) C09J 7/32 (20180101) Original (OR) Class C09J 2301/12 (20200801) C09J 2301/306 (20200801) C09J 2301/414 (20200801) C09J 2405/00 (20130101) C09J 2433/00 (20130101) C09J 2475/006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259479 | SIEGEL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| INVENTOR(S) | Donald Jason SIEGEL (Austin, Texas); Steven KIYABU (Ann Arbor, Michigan) |
| ABSTRACT | Compositions suitable for reversibly storing heat in thermal energy systems (TES) include a salt hydrate represented by the formula: MXq.nH2O. M is a cation selected from Groups 1 to 14 of the IUPAC Periodic Table, X is a halide of Group 17, q ranges from 1 to 4, and n ranges from 1 to 12. The cation (M) may have an electronegativity of ≤ about 1.8 and a molar mass ≤ about 28 g/mol. The anion (X) may have an electronegativity of ≥ about 2.9 to ≤ about 3.2. A distance between a cation (M) and coordinating water molecules (H2O) is ≤ about 2.1 Å. Thermal energy systems (TES) incorporating such compositions are also provided that are configured to reversibly store heat in the thermal energy system (TES) via an endothermic dehydration reaction and to release heat in in the thermal energy system (TES) via an exothermic hydration reaction. |
| FILED | Friday, January 21, 2022 |
| APPL NO | 17/581356 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 33/10705 (20130101) Compounds of Alkali Metals, i.e Lithium, Sodium, Potassium, Rubidium, Caesium, or Francium C01D 15/04 (20130101) Compounds of the Metals Beryllium, Magnesium, Aluminium, Calcium, Strontium, Barium, Radium, Thorium, or of the Rare-earth Metals C01F 5/28 (20130101) C01F 11/22 (20130101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 3/04 (20130101) C01G 23/028 (20130101) C01G 45/06 (20130101) C01G 49/10 (20130101) C01G 51/08 (20130101) C01G 53/08 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2006/36 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 5/16 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259641 | CHAO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. (BETHESDA, Maryland); THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (Silver Spring, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chien-Chung CHAO (North Potomac, Maryland); Wei-Mei CHING (Silver Spring, Maryland); Le JIANG (Clarksville, Maryland) |
| ABSTRACT | Methods, primers, and kits for detecting Anaplasma phagocytophilum (A. phagocytophilum) by amplification of a multi-copy DNA target sequence found within the msp2 gene of A. phagocytophilum are disclosed. Methods for treating A. phagocytophilum infections, including tick-borne fever and human granulocytic anaplasmosis are also disclosed. |
| FILED | Friday, July 17, 2020 |
| APPL NO | 17/627254 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) Original (OR) Class C12Q 1/6883 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259674 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan); Fred Hutchinson Cancer Center (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yuping Zhang (Ann Arbor, Michigan); Marcin Cieslik (Ann Arbor, Michigan); Arul M. Chinnaiyan (Ann Arbor, Michigan); Christopher I. Li (Seattle, Washington) |
| ABSTRACT | Provided herein are compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, provided herein are methods of treating basal-like breast cancer based on expression levels of a panel of cancer markers. |
| FILED | Thursday, February 17, 2022 |
| APPL NO | 17/674121 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) C12Q 1/6886 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259682 | Sawyer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sara L. Sawyer (Boulder, Colorado); Nicholas R. Meyerson (Broomfield, Colorado); Camile L. Paige (Westminster, Colorado); Qing Yang (Longmont, Colorado); Robin Dowell (Broomfield, Colorado) |
| ABSTRACT | The current inventive technology is directed to systems, methods, and compositions detection of host signatures of pathogenic infection, and in particular a rapid detection assay configured to detect target RNA transcripts that may be biomarkers of infection. In one embodiment, the invention includes systems, methods and compositions for the early detection of pathogens or infection in an asymptomatic subject through a novel lateral flow assay, which in a preferred embodiment may include a rapid self-administered test strip configured to detect one or more RNA transcript biomarkers produced by a subject's innate immune system in response to a pathogen or infection and present in saliva. |
| FILED | Thursday, March 03, 2022 |
| APPL NO | 17/686387 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/701 (20130101) Original (OR) Class C12Q 1/6804 (20130101) C12Q 1/6844 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259774 | Baughman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Ray H. Baughman (Dallas, Texas); Jiuke Mu (Plano, Texas); Monica Jung De Andrade (Dallas, Texas); Shaoli Fang (Richardson, Texas); Na Li (Dallas, Texas); Carter S. Haines (Murphy, Texas) |
| ABSTRACT | Sheath-run artificial muscles (or SRAMs) are described in which the dimensional changes and/or modulus changes of a sheath on the surface of a twisted or coiled host yarn or fiber drives torsional and tensile actuation. The sheath-core artificial muscle includes a sheath on a coiled core yarn or fiber that has inserted twist, in which the sheath does not include a yarn, the coiled core yarn or fiber includes a core yarn or fiber, the sheath can change volume, modulus, or a combination thereof when actuated by an influence source to drive actuation, and the influence source is selected from a group consisting of absorption processes, desorption processes, changes in temperature, changes in external pressure, changes in a magnetic field, changes in an electric field, exposures to actinic radiation, electrochemical charge and discharge, chemical reactions, and combinations thereof. These sheath-run muscles can be used for diverse applications, such as robots, robotic devices, energy harvesters, muscles that enable electrical energy harvesting, comfort-adjusting textiles, comfort-adjusting clothing, bio-powered intelligent muscles that control the release of drugs, muscles for appropriate drug delivery, intelligent muscles that sense their environment and actuate in response, muscles for artificial limbs and orthotic gloves, muscles for haptic applications, muscles that can perform in extreme environments, and muscles for intelligent solar panel positioning. |
| FILED | Thursday, May 07, 2020 |
| APPL NO | 17/610045 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/08 (20130101) A61F 2002/0894 (20130101) Crimping or Curling Fibres, Filaments, Threads, or Yarns; Yarns or Threads D02G 3/36 (20130101) Original (OR) Class D02G 3/448 (20130101) Spring, Weight, Inertia or Like Motors; Mechanical-power Producing Devices or Mechanisms, Not Otherwise Provided for or Using Energy Sources Not Otherwise Provided for F03G 7/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220260062 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| INVENTOR(S) | Na Li (Richardson, Texas); Carter S. Haines (Murphy, Texas); Marcio D. Lima (Richardson, Texas); Monica Jung DeAndrade (Richardson, Texas); Shaoli Fang (Richardson, Texas); Jiyoung Oh (Richardson, Texas); Mikhail E. Kozlov (Dallas, Texas); Dongseok Suh (Plano, Texas); Ray H. Baughman (Dallas, Texas) |
| ABSTRACT | Actuators (artificial muscles) comprising twisted polymer fibers generate tensile actuation when powered thermally. In some embodiments, the thermally-powered polymer fiber tensile actuator can be incorporated into an article, such as a textile or garment. |
| FILED | Monday, October 18, 2021 |
| APPL NO | 17/504305 |
| CURRENT CPC | Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/0007 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 6/00 (20130101) Spinning or Twisting D01H 1/10 (20130101) Crimping or Curling Fibres, Filaments, Threads, or Yarns; Yarns or Threads D02G 3/02 (20130101) D02G 3/26 (20130101) D02G 3/448 (20130101) Braiding or Manufacture of Lace, Including Bobbin-net or Carbonised Lace; Braiding Machines; Braid; Lace D04C 1/02 (20130101) Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles D10B 2401/046 (20130101) D10B 2401/061 (20130101) D10B 2509/00 (20130101) Spring, Weight, Inertia or Like Motors; Mechanical-power Producing Devices or Mechanisms, Not Otherwise Provided for or Using Energy Sources Not Otherwise Provided for F03G 7/06 (20130101) Original (OR) Class Electric Machines Not Otherwise Provided for H02N 10/00 (20130101) H02N 11/006 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/2925 (20150115) Y10T 428/249921 (20150401) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220260135 | Miller |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | LOC PERFORMANCE PRODUCTS, LLC (Plymouth, Michigan) |
| ASSIGNEE(S) | LOC PERFORMANCE PRODUCTS, LLC (Plymouth, Michigan) |
| INVENTOR(S) | Scott C. Miller (Troy, Michigan) |
| ABSTRACT | A method of operating a dual bidirectional input to single bidirectional output transmission is disclosed. The method includes providing said transmission. The method includes activating a computer controller capable of receiving torque data signals from a first bidirectional torque input, a second bidirectional torque input, and a single bidirectional torque output. The method includes determining torque input from said first and second bidirectional torque input, and determining whether to transmit torque to said single bidirectional torque output. In cases where it is so determined, the method involves transmitting torque to said single bidirectional torque output. |
| FILED | Thursday, December 02, 2021 |
| APPL NO | 17/540343 |
| CURRENT CPC | Arrangement or Mounting of Propulsion Units or of Transmissions in Vehicles; Arrangement or Mounting of Plural Diverse Prime-movers in Vehicles; Auxiliary Drives for Vehicles; Instrumentation or Dashboards for Vehicles; Arrangements in Connection With Cooling, Air Intake, Gas Exhaust or Fuel Supply of Propulsion Units in Vehicles B60K 6/365 (20130101) Gearing F16H 3/089 (20130101) Original (OR) Class F16H 3/091 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220260425 | Jacob et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Zubin Jacob (West Lafayette, Indiana); Liping Yang (Changchun, China PRC); Leif H Bauer (Lafayette, Indiana) |
| ABSTRACT | A bolometric imaging system is disclosed which includes an array of nano-pixels, each including an optical stack, each including an absorptive layer where incident radiation is converted to heat which simultaneously acts as a first electrode layer vertically disposed adjacent the Free Layer, a fixed magnetic polarity layer (Fixed Layer) in a first magnetic direction, a barrier layer vertically disposed adjacent to the Fixed Layer, a selective magnetic polarity layer (Free Layer) vertically disposed adjacent to the barrier layer, a second electrode layer vertically disposed adjacent the Fixed Layer. Photons absorbed by the optical stack are converted into heat to thereby switch magnetic polarity in the Free Layer. The switch in polarity does not require the stack to be reset to a neutral state prior to such switching. Each nano-pixel output is a digital signal generated by photons above a pre-determined energy threshold. The system further includes a readout circuit. |
| FILED | Sunday, July 26, 2020 |
| APPL NO | 17/627807 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 5/20 (20130101) Original (OR) Class G01J 2005/0077 (20130101) G01J 2005/202 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220260433 | Arrieta Diaz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PURDUE RESEARCH FOUNDATION (West Lafayette, Indiana) |
| ASSIGNEE(S) | PURDUE RESEARCH FOUNDATION (West Lafayette, Indiana) |
| INVENTOR(S) | Andres F. Arrieta Diaz (Lafayette, Indiana); Janav Parag Udani (West Lafayette, Indiana) |
| ABSTRACT | A sensor, comprising a deformable substrate, comprising a structural metamaterial in a first configuration; a plurality of raised structures disposed throughout the substrate, wherein the plurality of raised structures are invertible; a responsive material layer, wherein the responsive material layer is disposed on the plurality of raised structures and is configured to invert the plurality of raised structures in the presence of an external stimuli; and a plurality of second configurations of the deformable substrate that correspond to a plurality of inverted raised structures. |
| FILED | Monday, November 22, 2021 |
| APPL NO | 17/456078 |
| CURRENT CPC | Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/048 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220260517 | Oja et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ABBOTT DIABETES CARE INC. (Alameda, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen M. Oja (Alameda, California); Benjamin Feldman (Alameda, California) |
| ABSTRACT | A method for sensing an analyte utilizing a sensor, the sensor including a reference electrode and a working electrode including an analyte-specific enzyme and a redox mediator, where the method includes: providing the working electrode to the analyte; accumulating charge derived from the analyte reacting with the analyte-specific enzyme and the redox mediator; measuring a potential drift of the working electrode relative to the reference electrode over a period of time, and correlating a rate of the potential drift to a concentration of the analyte. |
| FILED | Friday, April 29, 2022 |
| APPL NO | 17/661531 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/002 (20130101) A61B 5/14532 (20130101) A61B 5/14865 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/001 (20130101) C12Q 1/004 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/3271 (20130101) G01N 27/3272 (20130101) G01N 27/3276 (20130101) G01N 27/3277 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220260675 | Cambrea et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Lee R. Cambrea (Bloomington, Indiana); Terry L. Chastain (Bedford, Indiana); Zachary A. Masner (Bloomington, Indiana); Eric Alan Hillenbrand (Evansville, Indiana) |
| ABSTRACT | Disclosed are apparatus and methods for determining a radar cross section (RCS) of countermeasure units such as chaff that utilizes ground level testing. An antenna platform is provided that is mounted to a support member at ground level and includes a radar transmit antenna disposed on the antenna platform, a radar receive antenna disposed on the antenna platform, and radar attenuating material disposed on the antenna platform linearly between the transmit antenna and the receive antenna for attenuating linear transmission of signals between the transmit antenna to the receive antenna. Additionally, low power transmitters used to enable safe ground testing are coupled to the transmit antenna for transmitting radar RF signals toward dispersed countermeasure units above the platform and also network analyzers coupled to the receive antenna that are capable of measuring the low power RF signals reflected by the dispersed countermeasure units. |
| FILED | Friday, February 18, 2022 |
| APPL NO | 17/674971 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/038 (20130101) G01S 7/41 (20130101) Original (OR) Class G01S 13/88 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220260821 | Glaser et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Adam K. Glaser (Seattle, Washington); Jonathan T.C. Liu (Seattle, Washington) |
| ABSTRACT | Apparatuses, systems, and methods for an open-top light-sheet (OTLS) microscope which includes an illumination objective and a collection objective which have optical axes which are non-orthogonal to each other. The optical axis of the collection objective may be orthogonal to a plane of the sample holder. The illumination and collection objective may be located below the sample holder. The OTLS microscope may optionally include a second collection objective which has an optical axis orthogonal to the optical axis of the illumination objective. The illumination objective may be an air objective, and the collection objective may be an immersion objective. |
| FILED | Thursday, May 05, 2022 |
| APPL NO | 17/737736 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 21/02 (20130101) G02B 21/06 (20130101) Original (OR) Class G02B 21/33 (20130101) G02B 21/361 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220261636 | Principe et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jose C. Principe (Gainesville, Florida); Shiyu Duan (Cupertino, California) |
| ABSTRACT | Embodiments of the present disclosure provide methods, apparatus, systems, computing devices, computing entities, and/or the like for training a machine learning model comprising a hidden module and an output module and configured for identifying one of a plurality of original labels for an input. In accordance with one embodiment, a method is provided that includes generating sufficiently-labeled data comprising example-pairs each associated with a sufficient label. The sufficient label of an example-pair indicates whether a first and a second input example have the same original label. The method further includes training the hidden module using the sufficiently-labeled data, and subsequently, training the output module using a plurality of input examples each having an original label. The plurality of input examples may be a plurality of fully-labeled data. The method further includes automatically providing the resulting trained machine learning model for use in prediction tasks. |
| FILED | Wednesday, January 26, 2022 |
| APPL NO | 17/584505 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/628 (20130101) G06K 9/6256 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220262500 | Matlage et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America as Represented by the Secretary of the Navy (Silver Spring, Maryland) |
| ASSIGNEE(S) | The United States of America as Represented by the Secretary of the Navy (Silver Spring, Maryland) |
| INVENTOR(S) | Karl M. Matlage (Fairfax, Virginia); Andrew Olson (San Diego, California); Tracy Negus (San Diego, California); Vern Wing (Coronado, California); Patrick Givens (Huntsville, Alabama); Josh Harper (Harvest, Alabama); James Young (Huntsville, Alabama); Jennifer Shah (Madison, Alabama) |
| ABSTRACT | The present invention discloses a computer implemented method for planning a medical logistic support for an operational scenario involving a CBRN event, with implementable plan include medical network laydowns, medical facility, equipment, personnel and medical consumable requirements. The method allow user to generate medical laydowns within a theater, model patient care, and identify the demand for medical care, model casualty transportation requirements, project patient clinical outcomes from the Point of Injury (POI) through evacuation from theater. |
| FILED | Monday, November 01, 2021 |
| APPL NO | 17/516473 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 50/26 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 40/20 (20180101) Original (OR) Class G16H 50/30 (20180101) G16H 70/60 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220262930 | Jain et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GLOBALFOUNDRIES U.S. Inc. (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vibhor Jain (Essex Junction, Vermont); Judson R. Holt (Ballston Lake, New York); Tayel Nesheiwat (Poughkeepsie, New York); John J. Pekarik (Underhill, Vermont); Christopher Durcan (Albany, New York) |
| ABSTRACT | Device structures and fabrication methods for a bipolar junction transistor. The device structure includes a substrate and a trench isolation region in the substrate. The trench isolation region surrounds an active region of the substrate. The device structure further includes a collector in the active region of the substrate, a base layer having a first section positioned on the active region and a second section oriented at an angle relative to the first section, an emitter positioned on the first section of the base layer, and an extrinsic base layer positioned over the trench isolation region and adjacent to the emitter. The second section of the base layer is laterally positioned between the extrinsic base layer and the emitter. |
| FILED | Tuesday, February 16, 2021 |
| APPL NO | 17/176251 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/0649 (20130101) H01L 29/732 (20130101) Original (OR) Class H01L 29/0804 (20130101) H01L 29/66272 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220263005 | HOWE |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | HOWE INDUSTRIES LLC (Scottsdale, Arizona) |
| ASSIGNEE(S) | HOWE INDUSTRIES LLC (Scottsdale, Arizona) |
| INVENTOR(S) | TROY HOWE (Scottsdale, Arizona) |
| ABSTRACT | A thermoelectric cooler including a thermoelectric junction and a radiation source. The thermoelectric cooler includes n-type material, p-type material, and an electrical power source. The radiation source emits ionizing radiation that increases electrical conductivity of the n and p type materials. Also detailed is a method of using radiation to reach high coefficient of performance (COP) values with a thermoelectric cooler that includes providing a thermoelectric cooler and a radiation source, with the thermoelectric cooler including an n-type material, p-type material, an electrical power source, and emitting ionizing radiation with the radiation source to increase the electrical conductivity which strips electrons from the n-type material, the p-type material, or both the n-type material and p-type material from their nuclei with the electrons then free to move within the material. |
| FILED | Tuesday, November 23, 2021 |
| APPL NO | 17/533205 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/16 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 35/26 (20130101) H01L 35/30 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220263215 | Bardo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| ASSIGNEE(S) | BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| INVENTOR(S) | Jason E. Bardo (Chelmsford, Massachusetts); Wesley N. Allen (Amherst, New Hampshire); Benjamin G. McMahon (Nottingham, New Hampshire) |
| ABSTRACT | An antenna positioner provided on a deployable vehicle. The antenna positioner includes a base and a frame having a plurality of plates oriented at an angle relative to one another. Each plate may include a low band antenna and a high band antenna. The base is located inside a chamber of the deployable vehicle. The frame is movable relative to the base between a collapsed position, where the entire frame is positioned within the chamber, and an extended position wherein at least a portion of the frame extends outwardly through an opening in the deployable vehicle's exterior wall. The frame is pivotally engaged with the base and a gearing mechanism pivots the frame between the collapsed position and the extended position to arrange the antennas at a desired orientation relative to the deployable vehicle's exterior wall so as to maximize the antenna's near-vertical Field of View (FoV). |
| FILED | Thursday, February 18, 2021 |
| APPL NO | 17/178372 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 1/08 (20130101) H01Q 1/32 (20130101) H01Q 1/125 (20130101) Original (OR) Class H01Q 1/1235 (20130101) H01Q 3/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220263267 | DelGenio et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph A. DelGenio (Marlborough, Massachusetts); Jonathan Hampton (Hudson, Massachusetts); Jason Glickman (Sudbury, Massachusetts); Tracy Lombardo (Seabrook, New Hampshire) |
| ABSTRACT | An assembly is provided for an electric system. This electric system assembly includes an electric cable and a seal element. The seal element circumscribes and is configured integral with the electric cable. The seal element is configured from or otherwise includes a conductive polymer composite material. |
| FILED | Monday, February 15, 2021 |
| APPL NO | 17/176090 |
| CURRENT CPC | Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors H01R 13/5205 (20130101) Original (OR) Class Installation of Electric Cables or Lines, or of Combined Optical and Electric Cables or Lines H02G 15/04 (20130101) H02G 15/013 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220263472 | Moody et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jesse Moody (Charlottesville, Virginia); Anjana Dissanayake (Charlottesville, Virginia); Benton H. Calhoun (Charlottesville, Virginia); Steven M. Bowers (Charlottesville, Virginia) |
| ABSTRACT | Low power radio frequency (RF) receivers and related circuits are described. |
| FILED | Thursday, January 16, 2020 |
| APPL NO | 17/595559 |
| CURRENT CPC | Amplifiers H03F 1/0222 (20130101) Original (OR) Class H03F 3/19 (20130101) H03F 2200/105 (20130101) H03F 2200/222 (20130101) H03F 2200/451 (20130101) Transmission H04B 1/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220263568 | Landry et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Blake J. Landry (Saint Martinville, Louisiana); Adam Trahan (Slidell, Louisiana); Samuel Bateman (Picayune, Mississippi); Charles R. Key (Diamondhead, Mississippi) |
| ABSTRACT | A method including configuring, an Iridium antenna of a deck box device, to receive satellite communications based in the L band frequency range, establishing a point-to-point connection with an L-band satellite communication device via a gateway device, the L-hand satellite communication device configured to receive sampled data from one or more sampling devices and receiving, by the Iridium antenna, one or more data messages from a respective sampling device via the established point-to-point connection. The method including parsing the Short Burst Data packets of each data message to retrieve the sampled data, converting, the retrieved sampled data from each respective data message into a common format, determining, one or more characteristics associated with the converted sampled data, generating a visualization based on the one or more determined characteristics, and actuating a strategic operation associated with the one or more sampling devices based on the generated visualization. |
| FILED | Friday, February 18, 2022 |
| APPL NO | 17/675048 |
| CURRENT CPC | Transmission H04B 7/18513 (20130101) Original (OR) Class Wireless Communication Networks H04W 76/14 (20180201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220263769 | Brewer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tony Brewer (Plano, Texas); David Patrick (McKinney, Texas) |
| ABSTRACT | A credit return field is used in a credit-based flow control system to indicate that one or more credits are being returned to a sending device from a receiving device. Based on the number of credits available, the sending device determines whether to send device or wait until more credits are returned. A write enable mask allows a wide data field to be used even when a smaller amount of data is to be written. A novel data packet uses a combined write enable mask and credit return field. In one mode, the field contains a write enable mask. In another mode, the field contains credit return data. If the field contains credit return data, a default value (e.g., all ones) is used for the write enable mask. The mode may be selected based on another value in the data packet. |
| FILED | Tuesday, May 03, 2022 |
| APPL NO | 17/735636 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 47/39 (20130101) Original (OR) Class H04L 49/9026 (20130101) H04L 2101/695 (20220501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220264058 | Portoghese et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States of America, as represented by the Secretary of the Navy (Patuxent River, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rocco Portoghese (Winter Park, Florida); Matthew Adams (Orlando, Florida); Joseph Vanciel (Orlando, Florida); Matthew Lankford (Merritt Island, Florida) |
| ABSTRACT | A device to capture data and video through a weapon's iron sight during live fire, wherein the iron sight has a rear aperture assembly and is able to adjust iron sight elevation. The device includes a beam splitter assembly, a camera, and camera body with a printed circuit board assembly with sensors and a controller, image sensor, device controller and an adjustment arm. The adjustment arm is mountable on the side of the iron sight assembly such that the camera body can be adjusted to the weapon line of sight in a horizontal/windage direction. The beamsplitter assembly splits the light and images to the image sensor and to the shooter's eye without disrupting the shooter's view of a target. The image sensor captures video of the image sent from the beamsplitter assembly. The device controller collects data from all the sensors and sends the data and video to a computer. |
| FILED | Thursday, February 18, 2021 |
| APPL NO | 17/178797 |
| CURRENT CPC | Weapon Sights; Aiming F41G 11/00 (20130101) Optical Elements, Systems, or Apparatus G02B 23/04 (20130101) Pictorial Communication, e.g Television H04N 7/185 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20220257185 | Shen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of The University of Alabama (Tuscaloosa, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiangrong Shen (Tuscaloosa, Alabama); Edward Sazonov (Northport, Alabama); Md Rejwanul Haque (Tuscaloosa, Alabama) |
| ABSTRACT | The present disclosure relates to systems and devices for measuring motion of a shoe and tension in the shoelace of the shoe. |
| FILED | Friday, December 10, 2021 |
| APPL NO | 17/547369 |
| CURRENT CPC | Fastenings or Attachments of Footwear; Laces in General A43C 1/003 (20130101) Diagnosis; Surgery; Identification A61B 5/112 (20130101) A61B 5/746 (20130101) A61B 5/1117 (20130101) A61B 5/6807 (20130101) Original (OR) Class A61B 5/7275 (20130101) Apparatus for Physical Training, Gymnastics, Swimming, Climbing, or Fencing; Ball Games; Training Equipment A63B 71/0619 (20130101) Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 5/047 (20130101) Measuring Linear or Angular Speed, Acceleration, Deceleration, or Shock; Indicating Presence, Absence, or Direction, of Movement G01P 13/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257236 | Khanicheh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | EnVision Endoscopy, Inc. (Somerville, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Azadeh Khanicheh (Somerville, Massachusetts); Isaac Ostrovsky (Wellesley, Massachusetts) |
| ABSTRACT | Provided herein is an endoscopic suturing system configured for attachment to, and use with, an endoscope. |
| FILED | Monday, June 21, 2021 |
| APPL NO | 17/353471 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/00087 (20130101) A61B 17/0469 (20130101) Original (OR) Class A61B 2017/00296 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257599 | HELLER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Memorial Sloan Kettering Cancer Center (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel HELLER (New York, New York); Christopher HOROSZKO (New York, New York) |
| ABSTRACT | The present technology is directed to methods useful in treating cancer, slowing growth of a tumor, reversing growth of a tumor, slowing growth of a neoplasm, reversing growth of a neoplasm, slowing proliferation of a neoplasm, and/or reversing proliferation of a neoplasm, for cancers, tumors, and neoplasms harboring a constitutively active variant of one or both of KRAS or HRAS, where the constitutively active variant is a gain of function mutation, a duplication, or a gene amplification. |
| FILED | Wednesday, July 15, 2020 |
| APPL NO | 17/626370 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/517 (20130101) Original (OR) Class A61K 31/4709 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257770 | Yao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Yuan Yao (West Lafayette, Indiana); Jingmin Zhang (West Lafayette, Indiana) |
| ABSTRACT | A material comprising a highly branched carbohydrate polymer, a polyalkylene glycol (or polyalkylene oxide) linked to the highly branched carbohydrate polymer, and a hydrophobic or amphiphilic group linked to the highly branched carbohydrate polymer and/or the polyalkylene glycol (or polyalkylene oxide), is described. Methods of making and using the material, as well as a soluble composition that contains the material and a hydrophobic solute compound, are also described. |
| FILED | Monday, April 25, 2022 |
| APPL NO | 17/728121 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/10 (20130101) A61K 9/1676 (20130101) A61K 9/1682 (20130101) A61K 9/5161 (20130101) A61K 31/12 (20130101) A61K 31/167 (20130101) A61K 31/337 (20130101) A61K 31/343 (20130101) A61K 31/496 (20130101) A61K 31/635 (20130101) A61K 47/36 (20130101) Original (OR) Class A61K 47/38 (20130101) A61K 47/40 (20130101) Polysaccharides; Derivatives Thereof C08B 37/0009 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/24 (20130101) C08J 2305/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257791 | Omarova et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Administrators of the Tulane Educational Fund (New Orleans, Louisiana); Board of Supervisors of Louisiana State Univeristy and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marzhana Omarova (Cambridge, Massachusetts); Vijay T. John (Destrehan, Louisiana); Donghui Zhang (Baton Rouge, Louisiana) |
| ABSTRACT | The disclosure relates to multilayered vesicles, methods for forming multilayered vesicles, and drug delivery complexes including multilayered vesicles. The multilayered vesicles can be formed by adding hydrophobe containing polypeptoid (HCP)-lipid complexes to unilamellar vesicles such as liposomes in an amount effective to form multilayered vesicles. The HCP-lipid complexes can be produced by mixing a hydrophobe containing polypeptoid (HCP) with a first set of unilamellar vesicles. The unilamellar vesicles and/or drug delivery complexes can include various cargoes for delivery, such as water-soluble cargoes, hydrophobic cargoes, etc. |
| FILED | Wednesday, February 16, 2022 |
| APPL NO | 17/673063 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1272 (20130101) A61K 47/6911 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220257827 | Boire et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VenoStent, Inc. (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Timothy C. Boire (Houston, Texas); Jordan S. Miller (Houston, Texas); Bagrat Grigoryan (Houston, Texas); Candice Sears (Houston, Texas) |
| ABSTRACT | Various precursor solutions and methods of 3D printing and other additive manufacturing approaches are provided for the manufacture of articles using photocrosslinkable vinyl shape memory polymers. In various aspects, articles are manufactured by a process comprising (i) exposing a precursor solution to an intensity and frequency of light to initiate photo-polymerization of the precursor solution to form a layer of the article; and (ii) repeating step (i) a number of times to form the article in a layer-by-layer approach; wherein the precursor solution comprises a first polymeric precursor comprising a plurality of vinyl terminated side-chains attached thereto. A vinyl-functionalized, photocrosslinkable SMP used as an example herein is a novel variant of a previously disclosed SMP composition, with higher amounts of vinyl functionalization but similar thermomechanical properties to the SMP library previously disclosed. Moreover, a unique combination of chemistries is disclosed that incorporates the aforementioned vinyl-functionalized SMPs along with acrylate-based crosslinkers. Additional novel compositions are disclosed containing the vinyl-functionalized SMPs with additional dithiol functionalizations, vinyl-functionalized SMPs with dithiol crosslinkers, as well as vinyl-functionalized SMPs with both acrylate-based and dithiol crosslinkers, as another means to tune degradation rates and other material properties. The articles can include a variety of articles such as stents, grafts, external sheaths, and the like. Beneficially, the printed articles can include a plurality of pores having an average diameter of about 50 pm to about 5000 pm, about 500 pm to about 2000 pm, or about 1000 pm even in the absence of a photoblocker. |
| FILED | Thursday, July 23, 2020 |
| APPL NO | 17/629621 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) Original (OR) Class A61L 27/58 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/129 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 70/00 (20141201) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/08 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/24 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/09 (20130101) C08K 5/0025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220258100 | KALYUZHNAYA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | San Diego State University (SDSU) Foundation, dba San Diego State UniversityResearch Foundation (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marina KALYUZHNAYA (San Diego, California); Richard HAMILTON (San Diego, California) |
| ABSTRACT | Provided are products of manufacture and methods for the removal of gaseous methane and carbon dioxide, for example, for the removal of environmental or atmospheric or anthropogenically produced gaseous methane and carbon dioxide. Products of manufacture as provided herein comprise living emission abolish filters (LEAFs) for the removal of methane and carbon dioxide, where the “living” component of the “emission abolish filter”, or biofilter, comprises a methane-capturing bioagent, optionally comprising halophilic methanotroph bacterium. Products of manufacture as provided herein are manufactured as arrays, sheets, microfibers and/or microbeads comprising immobilized living, active methane-capturing bioagents, optionally comprising halophilic methanotroph bacterium. In alternative embodiments, the methane-capturing bioagents are enclosed or immobilized in or onto a crystal gel matrix or a nanoshell. Products of manufacture as provided herein can replace gas flares, flare stacks or a gas combustion devices, or are used with a methane scrubbing system. |
| FILED | Thursday, July 16, 2020 |
| APPL NO | 17/627280 |
| CURRENT CPC | Separation B01D 53/62 (20130101) B01D 53/72 (20130101) B01D 53/85 (20130101) Original (OR) Class B01D 2251/95 (20130101) B01D 2257/504 (20130101) B01D 2257/7025 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/00 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/02 (20130101) C25B 1/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220258131 | BENICEWICZ et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF SOUTH CAROLINA (COLUMBIA, South Carolina); COLUMBIA UNIVERSITY (NEW YORK, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | BRIAN C. BENICEWICZ (COLUMBIA, South Carolina); YUCHENG HUANG (CHARLOTTESVILLE, Virginia); CONNOR R. BILCHAK (CLIFTON HEIGHTS, Pennsylvania); SANAT K. KUMAR (NEW YORK, New York) |
| ABSTRACT | Gas separation membranes as may be used in separating gaseous materials from one another and methods of forming the membranes are described. The separation membranes include polymer-grafted nanoparticles (GNPs) as a platform and a relatively small amount of free polymer. The free polymer and the polymer grafted to the nanoparticles have the same chemical structure and similar number average molecular weights. The gas separation membranes can exhibit high ideal selectivity and can be used in a variety of applications, such as carbon capture. |
| FILED | Tuesday, April 07, 2020 |
| APPL NO | 17/617113 |
| CURRENT CPC | Separation B01D 53/228 (20130101) B01D 63/10 (20130101) B01D 67/0079 (20130101) B01D 69/02 (20130101) B01D 69/08 (20130101) B01D 69/10 (20130101) B01D 69/148 (20130101) B01D 71/027 (20130101) B01D 71/40 (20130101) B01D 71/78 (20130101) B01D 2053/224 (20130101) B01D 2323/38 (20130101) B01D 2325/04 (20130101) B01D 2325/34 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/261 (20130101) B01J 20/3085 (20130101) B01J 20/28011 (20130101) B01J 20/28038 (20130101) Original (OR) Class B01J 2220/46 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 292/00 (20130101) C08F 2438/03 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220258146 | Veige et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam S. Veige (Gainesville, Florida); Stella Almeida Gonsales (Gainesville, Florida) |
| ABSTRACT | A tetraanionic OCO pincer ligand metal-oxo-alkylidene complex is prepared from a trianionic pincer ligand supported metal-alkylidyne. The metal can be tungsten or other group 5-7 transition metal. The tetraanionic pincer ligand metal-oxo-alkylidene complex, a trianionic OCO pincer ligand metal complex, or a trianionic ONO pincer ligand metal complex can be used to polymerize cycloalkenes. The poly(cycloalkene)s are predominantly cis-alkene macrocyclics. |
| FILED | Tuesday, January 18, 2022 |
| APPL NO | 17/577510 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/223 (20130101) Original (OR) Class B01J 31/2243 (20130101) B01J 31/2265 (20130101) B01J 31/2286 (20130101) B01J 2231/543 (20130101) B01J 2540/10 (20130101) B01J 2540/225 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 11/00 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 4/69 (20130101) C08F 4/78 (20130101) C08F 32/04 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 61/08 (20130101) C08G 2261/13 (20130101) C08G 2261/418 (20130101) C08G 2261/3324 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259244 | MORROW et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Research Foundation for The State University of New York (Buffalo, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Janet R. MORROW (Williamsville, New York); Eric M. SNYDER (Williamsville, New York); Didar ASIK (Buffalo, New York) |
| ABSTRACT | Provided are macrocyclic compounds and compounds with two or more macrocyclic groups, iron coordinated macrocyclic compounds, and iron coordinated compounds with two or more macrocyclic groups. The iron is high-spin iron(III). The iron coordinated compounds may exhibit a negative redox potential (e.g., relative to a normal hydrogen electrode at a biologically relevant pH, for example, a pH of 6.5-7.5). The compounds can be used as MRI contrast agents. |
| FILED | Monday, February 28, 2022 |
| APPL NO | 17/682695 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/085 (20130101) A61K 49/106 (20130101) A61K 49/124 (20130101) A61K 49/128 (20130101) A61K 49/143 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 15/025 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259258 | Lummiss et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MyTide Therapeutics, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Justin Alexander MacDonald Lummiss (Cambridge, Massachusetts); Chase R. Olle (Allston, Massachusetts); Kevin Shi (Boston, Massachusetts); Dale Arlington Thomas, III (Hampden, Maine) |
| ABSTRACT | The present disclosure provides coupling methods and systems for producing peptides or proteins using semi-continuous or continuous manufacturing techniques to enable rapid production of peptides and proteins using solid phase peptide synthesis (SPPS). The disclosure provides a higher degree of process control for peptide and protein product manufacturing using semi-continuous or continuous manufacturing techniques with inline analytics and automation. |
| FILED | Friday, June 12, 2020 |
| APPL NO | 17/618781 |
| CURRENT CPC | Peptides C07K 1/042 (20130101) Original (OR) Class C07K 1/045 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259266 | Ly et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Danith H. Ly (Pittsburgh, Pennsylvania); Suresh Kumar Gopalsamy (Tamilnadu, India); Arunava Manna (Pittsburgh, Pennsylvania) |
| ABSTRACT | Described herein are novel divalent nucleobases that each bind two nucleic acid strands, matched or mismatched when incorporated into a nucleic acid or nucleic acid analog backbone (a genetic recognition reagent, or genetic recognition reagent). In one embodiment, the genetic recognition reagent is a peptide nucleic acid (PNA) or gamma PNA (γPNA) oligomer. Uses of the divalent nucleobases and monomers and genetic recognition reagents containing the divalent nucleobases also are provided. |
| FILED | Tuesday, December 28, 2021 |
| APPL NO | 17/563570 |
| CURRENT CPC | Heterocyclic Compounds C07D 239/47 (20130101) C07D 239/54 (20130101) C07D 251/16 (20130101) C07D 471/04 (20130101) C07D 475/08 (20130101) C07D 487/04 (20130101) C07D 487/16 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 1/06 (20130101) C07H 21/04 (20130101) Peptides C07K 14/003 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6809 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5308 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259574 | Ai et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Huiwang Ai (Crozet, Virginia); Hsien-Wei Yeh (Seattle, Washington); Ying Xiong (Charlottesville, Virginia) |
| ABSTRACT | Provided herein are chemically modified luciferase substrates for spectrally shifted emission and enhanced water solubility. Provided herein are engineered luciferases. Moreover, provided herein are new ATP-independent bioluminescent reporters which have improved biochemical and photophysical properties and are expected to have broad applications. Finally, provided herein are spectral-resolved triple-color bioluminescent systems, suitable for flexible and convenient approaches to monitor multiple biological events in either qualitative or quantitative manners |
| FILED | Thursday, February 27, 2020 |
| APPL NO | 17/434351 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0069 (20130101) Original (OR) Class C12N 15/63 (20130101) Enzymes C12Y 113/12005 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/542 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259590 | Das et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Rhiju Das (Palo Alto, California); Joseph Yesselman (Stanford, California); Kalli Kappel (Stanford, California) |
| ABSTRACT | Systems and methods for generating RNA nanostructures capable of linking RNA structures and capable of securing aptamers in an active and stable structure are disclosed. Generally, RNA possesses many structural properties to create novel nanostructures and machines. RNA tertiary structure is composed of discrete and recurring components known as tertiary ‘motifs’. Along with the helices that they interconnect, many of these structural motifs appear highly modular. Systems and methods herein generate a motif library including canonical and noncanonical motifs to design a candidate path to connect one or more RNA molecules. These paths can also be used to secure RNA aptamers to improve aptamer stability and activity. |
| FILED | Monday, April 20, 2020 |
| APPL NO | 17/594487 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) Original (OR) Class C12N 2310/16 (20130101) C12N 2320/11 (20130101) C12N 2330/31 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 40/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259883 | Al-Haddad et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tristan Al-Haddad (Atlanta, Georgia); Russell Gentry (Atlanta, Georgia); Lawrence Bank (Atlanta, Georgia); Ammar Alshannaq (Atlanta, Georgia); Jamieson Pye (Atlanta, Georgia); Mehmet Bermek (Atlanta, Georgia) |
| ABSTRACT | An exemplary embodiment of the present disclosure provides an electric utility pole, comprising a beam, a base, and an arm. The beam can be formed from a retired turbine blade and can comprise a first end and a second end. The base connected to the first end of the beam. The arm can be connected to the beam. The arm can be configured to support at least one electrical conductor. |
| FILED | Wednesday, August 05, 2020 |
| APPL NO | 17/632993 |
| CURRENT CPC | Buildings or Like Structures for Particular Purposes; Swimming or Splash Baths or Pools; Masts; Fencing; Tents or Canopies, in General E04H 12/02 (20130101) Original (OR) Class E04H 12/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220260493 | Koide et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kazunori Koide (Pittsburgh, Pennsylvania); Melissa L. Campbell (Pittsburgh, Pennsylvania); Dianne Pham (Pittsburgh, Pennsylvania) |
| ABSTRACT | Methods of detecting platinum and copper in a test sample are provided. Kits for use in detecting platinum and copper in a test sample also are provided. |
| FILED | Monday, May 09, 2022 |
| APPL NO | 17/739579 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/643 (20130101) G01N 21/6428 (20130101) Original (OR) Class G01N 33/20 (20130101) Technical Subjects Covered by Former US Classification Y10T 436/16 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220260520 | Karhanek et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Miloslav Karhanek (Santa Cruz, California); Chris David Webb (Watsonville, California); Senkei Umehara (Tokyo, Japan); Nader Pourmand (San Mateo, California) |
| ABSTRACT | Disclosed are methods and devices for biomolecular detection, comprising a nanopipette, exemplified as a hollow inert, non-biological structure with a conical tip opening of nanoscale dimensions, suitable for holding an electrolyte solution which may contain an analyte such as a protein biomolecule to be detected as it is passed through the tip opening. Biomolecules are detected by specific reaction with peptide ligands chemically immobilized in the vicinity of the tip. Analytes which bind to the ligands cause a detectible change in ionic current. A sensitive detection circuit, using a feedback amplifier circuit, and alternating voltages is further disclosed. Detection of IL-10 at a concentration of 4 ng/ml is also disclosed, as is detection of VEGF. |
| FILED | Tuesday, January 18, 2022 |
| APPL NO | 17/578151 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/42 (20130101) Original (OR) Class G01N 27/4035 (20130101) G01N 33/48707 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220260663 | PADOS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | FLORIDA ATLANTIC UNIVERSITY RESEARCH CORPORATION (Boca Raton, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dimitris A. PADOS (Boca Raton, Florida); Konstantinos TOUNTAS (Boca Raton, Florida); Georgios SKLIVANITIS (Boca Raton, Florida) |
| ABSTRACT | A practically implementable robust direction-of-arrival (DoA) estimation approach that is resistant to localization errors due to mobility, multipath reflections, impulsive noise, and multiple-access interference. As part of the disclosed invention the inventors consider infrastructure-less 3D localization of autonomous underwater vehicles (AUVs) with no GPS assistance and no availability of global clock synchronization. The proposed method can be extended to challenging communication environments and applied for the localization of assets/objects in space, underground, intrabody, underwater and other complex, challenging, congested and sometimes contested environments. Each AUV leverages known-location beacon signals to self-localize and can simultaneously report its sensor data and measurement location. The approach uses two known location beacon nodes, where the beacons are single-hydrophone acoustic nodes that are deployed at known locations and transmit time-domain coded signals in a spread-spectrum fashion. |
| FILED | Friday, August 28, 2020 |
| APPL NO | 17/622584 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 1/753 (20190801) Original (OR) Class G01S 3/801 (20130101) G01S 3/8022 (20130101) G01S 5/24 (20130101) G01S 15/60 (20130101) G01S 15/582 (20130101) G01S 2201/07 (20190801) G01S 2205/04 (20200501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220261147 | Welch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregory Welch (Orlando, Florida); Ryan McMahan (Orlando, Florida); Gerd Bruder (Orlando, Florida) |
| ABSTRACT | A system for translating text streams of alphanumeric characters into preconfigured, haptic output. Text strings are parsed against a grammar index to locate assigned haptic or vibratory output. This may include speech-to-text, chat messaging, or text arrays of any kind. When a match is located, a standardized haptic output pattern is invoked through a haptic device. A device affordance module adapts the haptic output pattern to the capabilities of the target haptic device. |
| FILED | Friday, January 28, 2022 |
| APPL NO | 17/649229 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/014 (20130101) G06F 3/016 (20130101) G06F 3/04842 (20130101) G06F 3/04883 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220261463 | Chandrasekaran et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Varun Chandrasekaran (Madison, Wisconsin); Rahul Chatterjee (Madison, Wisconsin); Xiaohan Fu (San Diego, California); Jin-Yi Cai (Madison, California); Suman Banerjee (Madison, Wisconsin) |
| ABSTRACT | A biometric processing system for authentication combines multiple biometric signals using machine learning to map the different signals into a common argument space that may be processed by a similar fuzzy extractor. The different biometric signals may be given weight values related to their entropy allowing them to be blended to increase security and availability while minimizing intrusiveness. |
| FILED | Tuesday, February 16, 2021 |
| APPL NO | 17/177080 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/32 (20130101) Original (OR) Class G06F 21/40 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00892 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220261662 | Chandrasekar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (Blacksburg, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Prashant Chandrasekar (Natick, Massachusetts); Edward A. Fox (Blacksburg, Virginia) |
| ABSTRACT | The present disclosure describes various embodiments of extensible information systems and methods. One such system comprises a user interface configured to receive a query that includes a description of a research goal of a user; a reasoner configured to receive data from the user interface related to a user goal and generate a description of a workflow that will address the user goal, based on information in a knowledge graph and a services registry; and a workflow manager configured to receive a workflow description from the reasoner and manage an execution of workflows by scheduling for execution one or more services that are identified in the knowledge graph and described in the services registry. Other systems and methods are also provided. |
| FILED | Wednesday, February 16, 2022 |
| APPL NO | 17/673242 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/9024 (20190101) G06F 40/211 (20200101) Computer Systems Based on Specific Computational Models G06N 5/022 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220261682 | CALDERBANK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DUKE UNIVERSITY (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arthur Robert CALDERBANK (Durham, North Carolina); Jingzhen HU (Durham, North Carolina); Qingzhong LIANG (Durham, North Carolina) |
| ABSTRACT | Technologies for addressing coherent noise in a quantum system are disclosed. To passively correct for errors in measurement caused by coherent noise, the quantum system implements an error correction code such that the error correction code effectively reduces the coherent noise to act as an identity operator in a protected subspace of a Hilbert vector space. |
| FILED | Wednesday, February 16, 2022 |
| APPL NO | 17/673586 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/70 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220261990 | Goldberg et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ViQi, Inc. (Santa Barbara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ilya Goldberg (Santa Barbara, California); Dmitry Fedorov (Santa Barbara, California); Christian A. Lang (Santa Barbara, California); Kristian Kvilekval (Santa Barbara, California); Katherine Yeung (Santa Barbara, California); Henry Rupert Dodkins (Santa Barbara, California) |
| ABSTRACT | Methods and systems for machine learning are disclosed for early detection of morphological changes in cell condition of biological cells. In one disclosed embodiment, the development of vaccines and anti-virals are sped up using machine learning to identify viral plaques earlier than can be detected using human observation alone. In the disclosed embodiment, detecting morphological changes in virus-infected cells can be made before plaques caused by cell death are observable (typical cell death in 2-14 days). Machine learning brings high-content/high-throughput techniques to the study of virology for the development of novel anti-viral compounds. Machine learning can also be used to characterize the effectiveness of novel anti-viral compounds on rapidly mutating viral strains, such as influenza and SARS-CoV-2. |
| FILED | Friday, February 04, 2022 |
| APPL NO | 17/650067 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 2207/10056 (20130101) G06T 2207/20084 (20130101) G06T 2207/30072 (20130101) Image or Video Recognition or Understanding G06V 20/69 (20220101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220262164 | LIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Robert Bosch GmbH (Stuttgart, Germany); The Research Foundation for The State University of New York (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shan LIN (Jericho, New York); Hongkai CHEN (Smithtown, New York); Sirajum MUNIR (Pittsburgh, Pennsylvania) |
| ABSTRACT | Methods and systems for identifying persons utilizing a camera and a wireless transceiver. The wireless transceiver receives wireless packets (e.g., Wi-Fi packets) from one or more mobile devices associated with one or more persons. The channel state information (CSI) is determined based on signals associated with the packets, and first motion characteristics are determined based on the CSI data. Congruently, the camera generates images, and associated image data is received, wherein the image data is associated with the one or more persons. Second motion characteristics are determined based on the image data. The first motion characteristics are matched with the second motion characteristics along with a quantified uncertainty, and the matched motion characteristics are assigned with weights that are based on the second motion characteristics (e.g., image-based). The one or more persons are identified based on the matched motion characteristics and the weights. |
| FILED | Monday, April 25, 2022 |
| APPL NO | 17/728543 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 50/265 (20130101) Image or Video Recognition or Understanding G06V 10/98 (20220101) G06V 40/20 (20220101) Original (OR) Class Pictorial Communication, e.g Television H04N 7/183 (20130101) Wireless Communication Networks H04W 4/029 (20180201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220262457 | Pastore et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | International Business Machines Corporation (Armonk, New York); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vito Paolo Pastore (Lecce, Italy); Simone Bianco (San Francisco, California); Wallace Marshall (San Francisco, California) |
| ABSTRACT | Provided is a data-driven deep-learning based algorithm for synthetic biology applications that makes no assumptions and/or hypotheses on genotype-phenotype interactions. deep-learning based algorithm trains a neural network with morphological features from single genetic modifications and tests the neural network with morphological features from multiple genetic modifications. The trained and tested neural network uses a link between the morphological features caused by the single and multiple gene modifications as input and outputs a genotype-phenotype mapping highlighting perturbation subspaces. The genotype-phenotype mapping is used to select one or more genetic insults as a starting point to engineer cells in synthetic biology applications. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/175495 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6262 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) Original (OR) Class G16B 40/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220262972 | Honsberg et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Christiana Honsberg (Tempe, Arizona); Stuart Bowden (Tempe, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christiana Honsberg (Tempe, Arizona); Stuart Bowden (Tempe, Arizona) |
| ABSTRACT | Various embodiments of systems and methods for a solar module which concentrates light onto a solar cell while allowing diffuse light to pass to below crops are disclosed. |
| FILED | Monday, July 13, 2020 |
| APPL NO | 17/626432 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/048 (20130101) H01L 31/0236 (20130101) H01L 31/0547 (20141201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220263124 | Hu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Florida State University Research Foundation, Inc. (Tallahassee, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yan-Yan Hu (Tallahassee, Florida); Michael J. Deck (Tallahassee, Florida) |
| ABSTRACT | Electrolytes, methods of preparing electrolytes, and batteries include electrolytes. Electrolytes may include a material of formula (I), Li3PS4-xOx, wherein x is 0<x≤1. The electrolytes may be glass-ceramic electrolytes. Batteries including electrolytes may be lithium-ion batteries. |
| FILED | Wednesday, February 16, 2022 |
| APPL NO | 17/673547 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 25/14 (20130101) Compounds of Alkali Metals, i.e Lithium, Sodium, Potassium, Rubidium, Caesium, or Francium C01D 15/00 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/72 (20130101) C01P 2002/86 (20130101) C01P 2006/40 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0525 (20130101) H01M 10/0562 (20130101) Original (OR) Class H01M 2300/0071 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220263508 | Vrudhula et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona); The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sarma Vrudhula (Chandler, Arizona); Sunil Khatri (College Station, Texas); Ankit Wagle (Tempe, Arizona) |
| ABSTRACT | Threshold logic gates using flash transistors are provided. In an exemplary aspect, flash threshold logic (FTL) provides a novel circuit topology for realizing complex threshold functions. FTL cells use floating gate (flash) transistors to realize all threshold functions of a given number of variables. The use of flash transistors in the FTL cell allows a fine-grained selection of weights, which is not possible in traditional complementary metal-oxide-semiconductor (CMOS)-based threshold logic cells. Further examples include a novel approach for programming the weights of an FTL cell for a specified threshold function using a modified perceptron learning algorithm. |
| FILED | Friday, July 10, 2020 |
| APPL NO | 17/626719 |
| CURRENT CPC | Static Stores G11C 16/14 (20130101) G11C 16/28 (20130101) G11C 16/0483 (20130101) G11C 16/3404 (20130101) G11C 29/32 (20130101) Pulse Technique H03K 19/0027 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220263771 | Anwer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | AT and T Intellectual Property I, L.P. (Atlanta, Georgia); President and Fellows of Harvard University College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | AT and T Intellectual Property I, L.P. (Atlanta, Georgia); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Muhammad Bilal Anwer (Branchburg, New Jersey); Aman Shaikh (Berkeley Heights, New Jersey); Junzhi Gong (Cambridge, Massachusetts); Minlan Yu (Cambridge, Massachusetts); Yuliang Li (Cambridge, Massachusetts) |
| ABSTRACT | Performance issues in a service function chain having a plurality of resources and a plurality of network functions each having a network function queue are diagnosed. Each network function queue is monitored and queueing information for input packets for each of the plurality of network functions is dumped to a data store. Each resource that is under contention is identified as well as which of the network functions is a contender for the resources. A diagnosing algorithm is used to diagnose performance problems and an impact graph for each victim packet is generated. A summary of results as a list of rules is then provided. |
| FILED | Tuesday, May 03, 2022 |
| APPL NO | 17/735531 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 43/062 (20130101) H04L 43/0876 (20130101) H04L 47/522 (20130101) H04L 47/746 (20130101) H04L 47/748 (20130101) H04L 47/762 (20130101) Original (OR) Class H04L 47/803 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20220258145 | MA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida) |
| ASSIGNEE(S) | UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida) |
| INVENTOR(S) | Shengqian MA (Tampa, Florida); Zheng NIU (Tampa, Florida) |
| ABSTRACT | Described herein are compositions composed of frustrated Lewis pairs impregnated in porous materials such as, for example, metal-organic frameworks, and their uses thereof. These compositions may allow new applications of frustrated Lewis pairs in catalysis by sequestering and protecting the frustrated Lewis pair within the nanospace of the porous material. Also provided are methods of hydrogenating an organic compound having at least one unsaturated functional group comprising using the compositions described herein. |
| FILED | Tuesday, June 30, 2020 |
| APPL NO | 17/623801 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/0275 (20130101) B01J 31/1691 (20130101) Original (OR) Class B01J 2231/643 (20130101) B01J 2231/645 (20130101) B01J 2531/62 (20130101) Non-metallic Elements; Compounds Thereof; C01B 3/0015 (20130101) Acyclic or Carbocyclic Compounds C07C 67/303 (20130101) C07C 209/52 (20130101) C07C 213/02 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/027 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/04216 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220258164 | Zhu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Ying Zhu (Richland, Washington); Jongmin Woo (Richland, Washington); Ljiljana Pasa-Tolic (Richland, Washington) |
| ABSTRACT | A device for biological sample preparation and analysis is disclosed. The device includes a substrate and a plurality of spaced apart arrays disposed on an upper surface of the substrate. Each array includes a plurality of reaction vessels, each reaction vessel having a hydrophilic surface. A hydrophilic ring surrounds each array. Methods of making and using the device are also disclosed. |
| FILED | Wednesday, February 16, 2022 |
| APPL NO | 17/673407 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5088 (20130101) B01L 3/50853 (20130101) B01L 3/502707 (20130101) B01L 3/502753 (20130101) B01L 3/502792 (20130101) Original (OR) Class B01L 2200/12 (20130101) B01L 2200/16 (20130101) B01L 2200/142 (20130101) B01L 2300/165 (20130101) B01L 2300/0819 (20130101) B01L 2300/0822 (20130101) B01L 2300/0887 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/12 (20130101) G01N 33/6851 (20130101) G01N 2030/027 (20130101) G01N 2560/00 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/11 (20130101) G03F 7/32 (20130101) G03F 7/0392 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220258415 | LaPlant et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | HONEYWELL FEDERAL MANUFACTURING and TECHNOLOGIES, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | HONEYWELL FEDERAL MANUFACTURING and TECHNOLOGIES, LLC (Kansas City, Missouri) |
| INVENTOR(S) | Steven Todd LaPlant (Kansas City, Missouri); Michael Joseph Batrick (Kansas City, Missouri); Ruben Arturo Pino (Kansas City, Missouri) |
| ABSTRACT | A system and method of additively manufacturing a part via salt micro-spheres. The method includes mixing salt micro-spheres with an additive manufacturing material to form an additive manufacturing material mixture. The additive manufacturing material mixture is deposited on a build platform layer by layer and cured so as to create a structure having pores formed by the salt micro-spheres. The salt micro-spheres may then be dissolved and flushed from the pores. |
| FILED | Friday, April 29, 2022 |
| APPL NO | 17/732821 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/35 (20170801) B29C 64/165 (20170801) Original (OR) Class B29C 64/205 (20170801) B29C 64/245 (20170801) B29C 64/314 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 40/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259343 | Balema et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Viktor Balema (Ames, Iowa); Vitalij Pecharsky (Ames, Iowa); Duane Johnson (Ames, Iowa) |
| ABSTRACT | Various embodiments disclosed relate to unsaturated polymers that exhibit electrocaloric properties. The polymers can be useful as heat transfer materials in heating and cooling applications. |
| FILED | Wednesday, December 08, 2021 |
| APPL NO | 17/545925 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 8/26 (20130101) C08F 214/22 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 37/025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259399 | MECKLER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PALO ALTO RESEARCH CENTER INCORPORATED (PALO ALTO, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | STEPHEN MECKLER (Campbell, California); MAHATI CHINTAPALLI (Mountain View, California); GABRIEL IFTIME (Newark, California); ELI BULGER (Nottawa, Ontario, Canada) |
| ABSTRACT | A method of forming a porous, polymer aerogel, includes producing a miscible formulation of at least one of monomers, oligomers, crosslinkers and prepolymers, polymerizing the miscible formulation to form a multiphasic gel, wherein phases are continuous and the multiphasic gel has at least one depolymerizable domain and at least one non-depolymerizable domain, and the at least one depolymerizable domain is chemically bonded to the at least one non-depolymerizable domain, and removing the depolymerizable domain or domains from the multiphasic gel to produce a porous aerogel with a color rendering index of at least 25. A method of forming a porous, polymer aerogel, including producing a miscible formulation of at least one monomer, oligomer or crosslinker, and a prepolymer having at least one reactive functional group, polymerizing the miscible formulation to form a multiphasic gel, wherein the prepolymer having at least one reactive functional group is chemically bonded to a polymer that results from the polymerization of the at least one monomer or oligomer, and phases are continuous and the multiphasic gel has at least one depolymerizable domain bonded to at least one non-depolymerizable domain, and placing the multiphasic gel in a depolymerization solution having a depolymerization solvent to chemically degrade the depolymerizable domain into smaller oligomers and monomers, removing the depolymerization solvent to produce a porous aerogel with a color rendering index of at least 25. |
| FILED | Tuesday, May 03, 2022 |
| APPL NO | 17/735321 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 9/286 (20130101) Original (OR) Class C08J 2201/0464 (20130101) C08J 2205/026 (20130101) C08J 2205/042 (20130101) C08J 2353/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259490 | BEARD et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado); The Regents of the University of Colorado, a Body Corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Craig BEARD (Arvada, Colorado); Marissa Sally MARTINEZ (Wheat Ridge, Colorado); Zhiyuan HUANG (Lakewood, Colorado) |
| ABSTRACT | The present disclosure relates to a nanocrystal that includes a nanocrystal core, a first ligand coordinated to a first portion of a surface of the nanocrystal core, and a second ligand coordinated to a second portion of the surface, where the second ligand includes a first functionalized aromatic molecule. |
| FILED | Wednesday, June 10, 2020 |
| APPL NO | 17/615139 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 20/00 (20130101) General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/13 (20130101) Acyclic or Carbocyclic Compounds C07C 57/60 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/025 (20130101) Original (OR) Class C09K 11/661 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259533 | He et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Auburn University (Auburn, Alabama) |
| ASSIGNEE(S) | Auburn University (Auburn, Alabama) |
| INVENTOR(S) | Qinghua He (Auburn, Alabama); Jin Wang (Auburn, Alabama); Matthew V. Hilliard (Pelham, Georgia) |
| ABSTRACT | Culture systems and methods of using same. The systems include a housing defining an inner space. The inner space includes a headspace and at least a portion of a reservoir. A surface for immobilizing cells is moveable between the headspace and the reservoir. The systems can be used for coculturing methanotrophs and phototrophs for processing biogas and wastewater, particularly from anaerobic digesters. |
| FILED | Thursday, May 05, 2022 |
| APPL NO | 17/737447 |
| CURRENT CPC | Separation B01D 53/62 (20130101) B01D 53/72 (20130101) B01D 53/85 (20130101) B01D 2251/95 (20130101) B01D 2257/504 (20130101) B01D 2257/7022 (20130101) B01D 2258/05 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 3/325 (20130101) C02F 3/341 (20130101) C02F 3/2806 (20130101) C02F 3/2813 (20130101) C02F 3/2866 (20130101) C02F 2101/105 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/02 (20130101) Original (OR) Class C12M 23/18 (20130101) C12M 23/36 (20130101) C12M 23/58 (20130101) C12M 27/00 (20130101) C12M 29/00 (20130101) C12M 41/00 (20130101) C12M 43/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259621 | KING et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado); Utah State University (Logan, Utah); Montana State University (Bozeman, Montana); The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul Wayne KING (Golden, Colorado); Katherine Alice BROWN (Lakewood, Colorado); Lance C. SEEFELDT (Providence, Utah); John W. PETERS (Bozeman, Montana); Gordana DUKOVIC (Boulder, Colorado) |
| ABSTRACT | Disclosed herein are biohybrid protein complexes capable of using light energy to photocatalyze the reduction of N2 into NH3. Also provided are methods of using biohybrid protein complexes to enzymatically reduce N2 to NH3 using light rather than chemical energy as the driving force. These methods may also include the production and isolation of ammonia, hydrogen or both. |
| FILED | Monday, May 02, 2022 |
| APPL NO | 17/734809 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0095 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 3/00 (20130101) Original (OR) Class Enzymes C12Y 118/06001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259694 | ZIEMKIEWICZ et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | West Virginia University (Morgantown, West Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul ZIEMKIEWICZ (Morgantown, West Virginia); Aaron NOBLE (Blacksburg, West Virginia); Chris VASS (Rainelle, West Virginia) |
| ABSTRACT | In one aspect, the disclosure relates to a continuous process for treating acid mine drainage while simultaneously recovering a high-grade rare earth preconcentrate suitable for extraction of commercially valuable rare earth oxides. In a further aspect, the preconcentrate is from about 0.1% to 5% rare earth elements on a dry weight basis. In another aspect, the disclosure relates to a method for processing the preconcentrate to generate a pregnant leach solution that does not form gels or emulsions and is suitable for processing via solvent extraction. In another aspect, the disclosure relates to a system and plant for carrying out the disclosed process. In still another aspect, the disclosure relates to a composition containing rare earth elements produced by the process disclosed herein. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure. |
| FILED | Friday, July 17, 2020 |
| APPL NO | 17/627484 |
| CURRENT CPC | Production and Refining of Metals; Pretreatment of Raw Materials C22B 3/20 (20130101) C22B 3/065 (20130101) Original (OR) Class C22B 59/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220260030 | YUN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GM GLOBAL TECHNOLOGY OPERATIONS LLC (Detroit, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hanho YUN (Oakland Township, Michigan); Jun-mo KANG (Ann Arbor, Michigan) |
| ABSTRACT | A combustion mode module is configured to switch operation of a low-temperature combustion (LTC) engine between a spark ignition (SI) mode, a positive valve overlap (PVO) mode, and a negative valve overlap (NVO) mode. A spark control module is configured to control a spark plug to generate a spark in a cylinder of the LTC engine when the LTC engine is operating in the SI mode. A valve control module is configured to control intake and exhaust valves of the cylinder to yield a PVO and a NVO when the LTC engine is operating in the PVO mode and the NVO mode, respectively. An air/fuel (A/F) control module is configured to adjust a desired A/F ratio of the LTC engine to a rich A/F ratio when operation of the LTC engine is switched to the PVO mode from either one of the SI mode and the NVO mode. |
| FILED | Tuesday, February 16, 2021 |
| APPL NO | 17/176277 |
| CURRENT CPC | Controlling Combustion Engines F02D 13/0261 (20130101) F02D 41/0002 (20130101) F02D 41/403 (20130101) F02D 41/1475 (20130101) Original (OR) Class F02D 41/3035 (20130101) F02D 2041/002 (20130101) F02D 2200/08 (20130101) F02D 2200/101 (20130101) F02D 2200/0406 (20130101) Ignition, Other Than Compression Ignition, for Internal-combustion Engines; Testing of Ignition Timing in Compression-ignition Engines F02P 5/145 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220260243 | Trublowski et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | EATON INTELLIGENT POWER LIMITED (Dublin, Ireland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Trublowski (Troy, Michigan); Lucas Stahl (Detroit, Michigan); Jeremy Santiago (Southfield, Michigan); Christopher Ring (Derry, New Hampshire); Adikaramge Jayawardena (Manlius, New York); Ukwatte Lokuliyanage Indika Upendra Perera (Clifton Park, New York); Nadarajah Narendran (Clifton Park, New York); Nilay Mehta (Peachtree, Georgia); Jean Paul Freyssinier (Troy, New York) |
| ABSTRACT | A heat sink for a luminaire includes a central portion having a top surface and a bottom surface. The bottom surface is adapted to receive a lighting arrangement. The heat sink further includes a plurality of arms configured to dissipate heat generated by the lighting arrangement. The plurality of arms extend radially outward from the central portion. Each one of the plurality of arms is substantially arcuate between a proximal end and a distal end. |
| FILED | Friday, January 28, 2022 |
| APPL NO | 17/587483 |
| CURRENT CPC | Non-electric Light Sources Using Luminescence; Light Sources Using Electrochemiluminescence; Light Sources Using Charges of Combustible Material; Light Sources Using Semiconductor Devices as Light-generating Elements; Light Sources Not Otherwise Provided for F21K 9/235 (20160801) Functional Features or Details of Lighting Devices or Systems Thereof; Structural Combinations of Lighting Devices With Other Articles, Not Otherwise Provided for F21V 29/83 (20150115) F21V 29/777 (20150115) Original (OR) Class Indexing Scheme Associated With Subclasses F21K, F21L, F21S and F21V, Relating to the Form or the Kind of the Light Sources or of the Colour of the Light Emitted F21Y 2115/10 (20160801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220260394 | HUA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CLEMSON UNIVERSITY (Clemson, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | LIWEI HUA (CLEMSON, South Carolina); HAI XIAO (CLEMSON, South Carolina); LAWRENCE C. MURDOCH (CLEMSON, South Carolina) |
| ABSTRACT | Systems and methods of signal processing for sensors are disclosed. Signal processing methods and systems demodulate the optical interference phase of cascaded individual optical fiber intrinsic Fabry-Perot interferometric sensors in a coherent microwave-photonic interferometry distributed sensing system. The chirp effect of an electro-optic modulator (EOM) is used to create a quasi-quadrature optical interference phase shift between two adjacent pulses which correspond to two adjacent reflection points in the time domain. The phase shift can be controlled by adjusting the bias voltage that is applied to the EOM. The interference phase is calculated by elliptically fitting the phase shift. The interference phase change is proportional to the optical path difference (OPD) change of the interferometer, and the sign can be used to differentiate the increase or decrease of the OPD. The approach shows good linearity, high resolution, and large dynamic range for distributed strain sensing. |
| FILED | Tuesday, January 25, 2022 |
| APPL NO | 17/584017 |
| CURRENT CPC | Measuring Not Specially Adapted for a Specific Variable; Arrangements for Measuring Two or More Variables Not Covered in a Single Other Subclass; Tariff Metering Apparatus; Measuring or Testing Not Otherwise Provided for G01D 5/35332 (20130101) Original (OR) Class Measurement of Mechanical Vibrations or Ultrasonic, Sonic or Infrasonic Waves G01H 9/004 (20130101) Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 7/025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220260511 | Reyes |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karla Rosa Reyes (Livermore, California) |
| ABSTRACT | A system for characterizing thermal properties of thermally anisotropic heterogeneous samples includes a heating element, a first temperature sensing device, a second temperature sensing device, and a computing system. The heating element is positioned at a first location within a sample and heats the sample. The first temperature sensing device outputs data indicative of temperatures of the first location to the computing device. The second temperature sensing device outputs data indicative of temperatures of the second location to the computing device. The computing device computes a thermal conductivity of the sample based upon the temperatures of the first location. The computing device further outputs an indication of a portion of the sample to which the thermal conductivity pertains based upon the second temperatures. |
| FILED | Tuesday, May 03, 2022 |
| APPL NO | 17/735581 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 25/18 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220260541 | Small et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Leo J. Small (Albuquerque, New Mexico); Susan Elizabeth Henkelis (Albuquerque, New Mexico); Stephen J. Percival (Albuquerque, New Mexico); Tina M. Nenoff (Albuquerque, New Mexico) |
| ABSTRACT | Detection and capture of toxic nitrogen oxides (NOx) is important for emissions control of exhaust gases and general public health. The low power sensor provides direct electrically detection of trace (0.5-5 ppm) NO2 at relatively low temperatures (50° C.) via changes in the electrical properties of nitrogen-oxide-capture active materials. For example, the high impedance of MOF-74 enables applications requiring a near-zero power sensor or dosimeter, such as for smart industrial systems and the internet of things, with 0.8 mg MOF-74 active material drawing <15 pW for a macroscale sensor 35 mm2 area. |
| FILED | Thursday, February 11, 2021 |
| APPL NO | 17/173333 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/227 (20130101) G01N 33/0037 (20130101) Original (OR) Class G01N 2027/222 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220260843 | Rushford et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Rushford (Livermore, California); Hoang T. Nguyen (Livermore, California) |
| ABSTRACT | A transmission grating optical beam combiner is provided. In some implementations, the beam combiner can include an optically transparent substrate and a transmission grating on the substrate. The transmission grating can be configured to combine and/or superimpose first and second input beams as a single output beam. The first input beam can be incident on the transmission grating at an angle corresponding to one diffraction order of the grating and the second input beam can be incident on the transmission grating at an angle corresponding to another diffraction order of the grating. |
| FILED | Thursday, February 10, 2022 |
| APPL NO | 17/650615 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 5/1866 (20130101) G02B 6/29311 (20130101) G02B 27/1086 (20130101) Original (OR) Class Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/4012 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220261350 | Kotra et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Advanced Micro Devices, Inc. (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jagadish Kotra (Austin, Texas); John Kalamatianos (Arlington, Massachusetts) |
| ABSTRACT | An electronic device includes a processor, the processor having a cache memory, a set of physical registers, and a promotion logic functional block. When one or more promotion conditions are met, the promotion logic functional block promotes prefetched data from a portion of a cache block in the cache memory to a physical register among the set of physical registers. For promoting the prefetched data, the promotion logic functional block acquires the prefetched data from the portion of the cache block and stores the prefetched data in the physical register |
| FILED | Wednesday, April 27, 2022 |
| APPL NO | 17/730754 |
| CURRENT CPC | Electric Digital Data Processing G06F 12/0862 (20130101) Original (OR) Class G06F 2212/602 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220262613 | PRIETO CONAWAY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Maria C. PRIETO CONAWAY (Pleasanton, California); Joshua R. DEOTTE (Livermore, California); Nikola DUDUKOVIC (Hayward, California); Eric B. DUOSS (Danville, California); Bryan D. MORAN (Pleasanton, California) |
| ABSTRACT | The present disclosure relates to a lattice substrate adapted for use in direct ionization mass spectrometry. The substrate may have a plurality of tessellated unit cells forming an integral structure. Each tessellated unit cell may have a dimension of no more than about 1.5 mm and may include a plurality of pores arranged in an ordered pattern. The substrate may further include a form factor suitable for use with a direct ionization mass spectrometry system. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/175302 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Electric Discharge Tubes or Discharge Lamps H01J 49/0409 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220263060 | FINEGAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Donal Patrick FINEGAN (Lakewood, Colorado); Kandler Alan SMITH (Golden, Colorado); Dana Birute KERN (Golden, Colorado); Bertrand Jean-Francois Tremolet de VILLERS (Golden, Colorado); Andrew Michael COLCLASURE (Morrison, Colorado); Francois Laurent Emilien USSEGLIO-VIRETTA (Lakewood, Colorado) |
| ABSTRACT | The present disclosure relates to utilizing laser ablation to selectively remove regions of active material from lithium-ion battery electrodes during production, forming channels. These channels may improve the radius of curvature of the lithium-ion battery, form patterns on the surface of the electrode to store excess electrolyte, provide improved access to external sources of lithium during pre-lithiation or re-lithiation, and/or lower the tortuosity of electrodes for enhanced ion transfer between electrodes during cycling in prismatic cells and cylindrical cells. |
| FILED | Tuesday, February 15, 2022 |
| APPL NO | 17/651093 |
| CURRENT CPC | Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/0643 (20130101) B23K 26/0648 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/04 (20130101) H01M 4/13 (20130101) Original (OR) Class H01M 4/139 (20130101) H01M 10/0525 (20130101) H01M 2004/021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220263086 | LIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Virginia Tech Intellectual Properties, Inc. (Blacksburg, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Feng LIN (Christianburg, Virginia); Linqin MA (Blacksburg, Virginia); James D, STEINER (Blacksburg, Virginia) |
| ABSTRACT | In one aspect, the disclosure relates to electrochemically active materials for use in constructing cathodes in lithium ion batteries. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure. In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, the disclosure, in one aspect, relates to electrochemically active materials for use as cathodes in lithium-ion batteries, methods of introducing dopants into the electrochemically active materials, and electrochemical cells and batteries comprising the same. Cathodes made using the electrochemically active materials disclosed herein exhibit smoother voltage profiles as well as enhanced specific energy, cycle life, rate capability, self-discharge resistance, and thermal stability compared to conventional cathodes. |
| FILED | Sunday, June 28, 2020 |
| APPL NO | 17/623578 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/0404 (20130101) H01M 4/525 (20130101) Original (OR) Class H01M 4/587 (20130101) H01M 4/623 (20130101) H01M 4/625 (20130101) H01M 10/446 (20130101) H01M 10/0525 (20130101) H01M 2004/021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220263104 | CHIANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); 24M Technologies, Inc. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yet-Ming CHIANG (Weston, Massachusetts); William Craig CARTER (Jamaica Plain, Massachusetts); Mihai DUDUTA (Somerville, Massachusetts); Pimpa LIMTHONGKUL (Boston, Massachusetts) |
| ABSTRACT | Redox flow devices are described including a positive electrode current collector, a negative electrode current collector, and an ion-permeable membrane separating said positive and negative current collectors, positioned and arranged to define a positive electroactive zone and a negative electroactive zone; wherein at least one of said positive and negative electroactive zone comprises a flowable semi-solid composition comprising ion storage compound particles capable of taking up or releasing said ions during operation of the cell, and wherein the ion storage compound particles have a polydisperse size distribution in which the finest particles present in at least 5 vol % of the total volume, is at least a factor of 5 smaller than the largest particles present in at least 5 vol % of the total volume. |
| FILED | Friday, April 22, 2022 |
| APPL NO | 17/727183 |
| CURRENT CPC | Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 50/64 (20190201) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/20 (20130101) H01M 8/188 (20130101) H01M 8/0206 (20130101) H01M 8/0215 (20130101) H01M 8/0221 (20130101) H01M 8/0228 (20130101) H01M 8/0234 (20130101) Original (OR) Class Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/50 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 10/70 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220263127 | FRANCISCO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Solid Power Operating, Inc. (Louisville, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian E. FRANCISCO (Arvada, Colorado); Heather A.S. PLATT (Golden, Colorado); Collin R. BECKER (Boulder, Colorado); Joshua BUETTNER-GARRETT (Arvada, Colorado) |
| ABSTRACT | A solid electrolyte material comprises Li, T, X and A wherein T is at least one of P, As, Si, Ge, Al, and B; X is one or more halogens or N; A is one or more of S and Se. The solid electrolyte material has peaks at 17.8°±0.75° and 19.2°±0.75° in X-ray diffraction measurement with Cu-Kα(1,2)=1.5418 Å and may include glass ceramic and/or mixed crystalline phases. |
| FILED | Monday, May 02, 2022 |
| APPL NO | 17/734874 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/052 (20130101) H01M 10/0562 (20130101) Original (OR) Class H01M 2300/0068 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220263130 | CHEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xi CHEN (Oak Ridge, Tennessee); Yiman ZHANG (Oak Ridge, Tennessee); Tomonori SAITO (Oak Ridge, Tennessee); Nancy J. DUDNEY (Oak Ridge, Tennessee); Michelle LEHMANN (Oak Ridge, Tennessee) |
| ABSTRACT | An improved gel composite electrolyte membrane and a method of its manufacture are provided. The method includes mixing polymer precursors, a lithium salt, and a ceramic filler in a vessel to form a mixture. The mixture is cast on a preheated substrate and cured to form a crosslinked composite electrolyte membrane. The composite electrolyte membrane is plasticized by immersing the composite electrolyte in a plasticizer to obtain a gel composite electrolyte membrane. The addition of a plasticizer and a ceramic filler synergistically and simultaneously act to improve the Li+ transference number and Li+ conductivity of the resulting composite electrolyte, exhibiting high ionic conductivity and mechanical stability as well improved cycling performance. The gel composite electrolyte membrane is particularly suitable for, but not limited to, lithium metal batteries. |
| FILED | Friday, February 18, 2022 |
| APPL NO | 17/675070 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0525 (20130101) H01M 10/0565 (20130101) Original (OR) Class H01M 2300/0082 (20130101) H01M 2300/0085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220263137 | Visco et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PolyPlus Battery Company (Berkeley, California) |
| ASSIGNEE(S) | PolyPlus Battery Company (Berkeley, California) |
| INVENTOR(S) | Steven J. Visco (Berkeley, California); Vitaliy Nimon (San Francisco, California); Ian Wogan (Oakland, California); Yevgeniy S. Nimon (Danville, California); Lutgard C. De Jonghe (Lafayette, California); Bruce D. Katz (Moraga, California) |
| ABSTRACT | Solid-state laminate electrode assemblies and various methods for making the solid-state laminate electrode assemblies involve a lithium metal layer reactively bonded to a lithium ion conducting sulfide glass layer. During manufacture, highly reactive surfaces of the lithium metal layer and the lithium ion conducting sulfide glass layer are maintained in its substantially unpassivated state until they have been reactively bonded. |
| FILED | Monday, November 01, 2021 |
| APPL NO | 17/453033 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/382 (20130101) H01M 4/0407 (20130101) H01M 4/1395 (20130101) H01M 10/052 (20130101) H01M 10/0525 (20130101) H01M 10/0562 (20130101) H01M 10/0585 (20130101) Original (OR) Class H01M 2300/0068 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220263344 | LETHELLIER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wireless Advanced Vehicle Electrification, LLC (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Patrice LETHELLIER (Salt Lake City, Utah); Kelly WARDELL (Stansbury Park, Utah); Adeel ZAHEER (West Valley, Utah) |
| ABSTRACT | Described herein is a structure, the implementation of which may result in optimization of power transfer within a wireless power transfer pad. Such a structure comprises two planes in parallel that each comprise multiple windings. Additionally, the structure may include two magnetic structures that each pass through the centers of the multiple windings of one of the respective planes. In some embodiments, a magnetic structure may include a main section and two vertical sections. In some cases, the magnetic structure may further include at least one side section that connects with a vertical section. |
| FILED | Wednesday, December 15, 2021 |
| APPL NO | 17/551743 |
| CURRENT CPC | Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 50/005 (20200101) Original (OR) Class H02J 50/12 (20160201) H02J 50/40 (20160201) H02J 50/90 (20160201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220263405 | Singh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Deere and Company (Moline, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brij N. Singh (West Fargo, North Dakota); Tianjun Fu (Moline, Illinois); Zachary Wehri (Moline, Illinois) |
| ABSTRACT | A system and method for controlling a dual active bridge based DC/DC converter. A controller implements a startup control scheme and DC bus pre-charge routine to prevent damage to the converter upon startup. During startup of the converter, the startup control process can be used to prevent excessive phase-shift and the DC bus pre-charge routine adjusts the pulse width modulated duty cycle by increasing the dead time between signals, resulting in a decreased DC bus capacitor. |
| FILED | Friday, September 24, 2021 |
| APPL NO | 17/484823 |
| CURRENT CPC | Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/0009 (20210501) H02M 1/0029 (20210501) H02M 1/36 (20130101) Original (OR) Class H02M 3/33584 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20220258242 | Schoenung et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Julie M. Schoenung (Oakland, California); Katherine A. Acord (Oakland, California); Baolong Zheng (Oakland, California); Umberto Scipioni Bertoli (Oakland, California); Andrew A. Shapiro (Pasadena, California); Qian Nataly Chen (Pasadena, California); William C. West (Pasadena, California) |
| ABSTRACT | In some embodiments, high-energy additive manufacturing (HE-AM) (e.g., directed energy deposition, powder injection, powder bed fusion, electron beam melting, solid-state, and ultrasonic) is used to overcome constraints of comparative EES fabrication techniques to produce chemical additive-free electrodes with complex, highly versatile designs for next generation EES. An exemplary rapid fabrication technique provides an approach for improving electrochemical performance while increasing efficiency and sustainability, reducing time to market, and lowering production costs. With this exemplary technique, which utilizes computer models for location specific layer-by-layer fabrication of three-dimensional parts (e.g., versatile design), a high degree of control over processing conditions may be achieved to enhance both the design and performance of EES systems. |
| FILED | Friday, April 24, 2020 |
| APPL NO | 17/622691 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/28 (20210101) Original (OR) Class Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/352 (20151001) B23K 2101/36 (20180801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 80/00 (20141201) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/0402 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259709 | MANUEL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida); United States Of America As Represented By The Administrator of NASA (WASHINGTON, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | MICHELE VIOLA MANUEL (GAINESVILLE, Florida); CHARLES ROBERT FISHER (FAIRFAX, Virginia); MARIA CLARA WRIGHT (ORLANDO, Florida) |
| ABSTRACT | Disclosed herein is a composite comprising a metal alloy matrix; where the metal alloy matrix comprises aluminum in an amount greater than 50 atomic percent; a first metal and a second metal; where the first metal is different from the second metal; and where the metal alloy matrix comprises a low temperature melting phase and a high temperature melting phase; where the low temperature melting phase melts at a temperature that is lower than the high temperature melting phase; and a contracting constituent; where the contracting constituent exerts a compressive force on the metal alloy matrix at a temperature between a melting point of the low temperature melting phase and a melting point of the high temperature melting phase or below the melting points of the high and low temperature melting phases. |
| FILED | Thursday, April 28, 2022 |
| APPL NO | 17/661054 |
| CURRENT CPC | Casting of Metals; Casting of Other Substances by the Same Processes or Devices B22D 19/00 (20130101) B22D 21/007 (20130101) Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 2301/15 (20130101) Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 15/20 (20130101) B32B 2307/54 (20130101) Alloys C22C 1/0416 (20130101) C22C 1/1036 (20130101) C22C 1/1084 (20130101) C22C 21/02 (20130101) C22C 21/14 (20130101) C22C 49/06 (20130101) C22C 49/14 (20130101) Changing the Physical Structure of Non-ferrous Metals and Non-ferrous Alloys C22F 1/006 (20130101) Original (OR) Class C22F 1/043 (20130101) C22F 1/057 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220260462 | Volckens et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Colorado State University Research Foundation (Fort Collins, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Volckens (Fort Collins, Colorado); Christian L'Orange (Fort Collins, Colorado); Gabriel Neymark (Golden, Colorado); Ellison Carter (Fort Collins, Colorado) |
| ABSTRACT | Disclosed are methods and systems for implementing an automated air quality analysis system. The system includes: a sealed enclosure, a filter sample analysis system disposed within the sealed enclosure, and a controller operably coupled with the filter sample analysis system. The filter sample analysis system includes: an automated filter management system with filter samples and an articulating robotic arm which selects the filter sample for analysis, a filter weighing apparatus for weighting of the filter sample, and a primary chemical analysis apparatus for performing electromagnetic energy spectroscopy measurement on the filter sample. The controller operates the automated filter management system to transport the filter sample to the filter weighing apparatus and the primary chemical analysis apparatus, obtains data from the filter sample analysis system, and determines the type and amount of accumulated mass in the sample based on the weight and the spectroscopy measurement result. |
| FILED | Friday, February 11, 2022 |
| APPL NO | 17/670204 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/1679 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/2205 (20130101) G01N 1/2273 (20130101) Original (OR) Class G01N 21/3518 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220263005 | HOWE |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HOWE INDUSTRIES LLC (Scottsdale, Arizona) |
| ASSIGNEE(S) | HOWE INDUSTRIES LLC (Scottsdale, Arizona) |
| INVENTOR(S) | TROY HOWE (Scottsdale, Arizona) |
| ABSTRACT | A thermoelectric cooler including a thermoelectric junction and a radiation source. The thermoelectric cooler includes n-type material, p-type material, and an electrical power source. The radiation source emits ionizing radiation that increases electrical conductivity of the n and p type materials. Also detailed is a method of using radiation to reach high coefficient of performance (COP) values with a thermoelectric cooler that includes providing a thermoelectric cooler and a radiation source, with the thermoelectric cooler including an n-type material, p-type material, an electrical power source, and emitting ionizing radiation with the radiation source to increase the electrical conductivity which strips electrons from the n-type material, the p-type material, or both the n-type material and p-type material from their nuclei with the electrons then free to move within the material. |
| FILED | Tuesday, November 23, 2021 |
| APPL NO | 17/533205 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/16 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 35/26 (20130101) H01L 35/30 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220263092 | Kuwata et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Nissan North America, Inc. (Franklin, Tennessee); United States of America as Represented by the Administrator of NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shigemasa Kuwata (Palo Alto, California); Hideyuki Komatsu (Yokosuka, Japan); Maarten Sierhuis (San Francisco, California); Balachandran Gadaguntla Radhakrishnan (San Mateo, California); Shreyas Honrao (Sunnyvale, California); John Lawson (San Francisco, California) |
| ABSTRACT | A lithium battery has a composite cathode comprising cathode active material including a transition metal oxide and an ion-conducting material having an electrochemical stability window against lithium of at least 2.2 V, a lowest electrochemical stability being less than 2.0 V and a highest electrochemical stability being greater than 4.2 V, the ion-conducting material selected from one or more of: Cs2LiCl3; Cs3Li2Cl5; Cs3LiCl4; CsLiCl2; Li2B3O4F3; Li3AlF6; Li3ScCl6; Li3ScF6; Li3YF6; Li9Mg3P4O16F3; LiBF4; LiThF5; Na3Li3Al2F12; and NaLi2AlF6. |
| FILED | Monday, February 08, 2021 |
| APPL NO | 17/170129 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/62 (20130101) Original (OR) Class H01M 4/382 (20130101) H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 10/052 (20130101) H01M 10/0562 (20130101) H01M 10/0585 (20130101) H01M 2300/0068 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220263995 | Bathel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Of America As Represented By The Administrator Of Nasa (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brett F. Bathel (Yorktown, Virginia); Stephen B. Jones (Newport News, Virginia); Joshua M. Weisberger (Newport News, Virginia) |
| ABSTRACT | One aspect of the present disclosure is an imaging system including an optical sensor defining an optical axis. The system further includes a light source. The system may include an optical beam splitter, and may also include an optional diffusing lens that may be configured to diffuse and/or collimate light from the light source and direct light exiting the diffusing lens to the optical beam splitter. The optical beam splitter is configured to direct light from the light source along the optical axis of the optical sensor. |
| FILED | Monday, August 24, 2020 |
| APPL NO | 17/001037 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 27/149 (20130101) Apparatus or Arrangements for Taking Photographs or for Projecting or Viewing Them; Apparatus or Arrangements Employing Analogous Techniques Using Waves Other Than Optical Waves; Accessories Therefor G03B 15/05 (20130101) G03B 2215/0567 (20130101) G03B 2215/0582 (20130101) G03B 2215/0592 (20130101) Image Data Processing or Generation, in General G06T 11/003 (20130101) G06T 2207/10072 (20130101) Pictorial Communication, e.g Television H04N 5/247 (20130101) H04N 5/2253 (20130101) H04N 5/2254 (20130101) H04N 5/2256 (20130101) H04N 5/2354 (20130101) Original (OR) Class H04N 7/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Non-Profit Organization (NPO)
| US 20220259585 | Liu |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | The Texas A and M University System (College Station, Texas) |
| INVENTOR(S) | Wenshe Liu (College Station, Texas) |
| ABSTRACT | Embodiments of the present disclosure pertain to methods of constructing a phage display library where at least 90% of combinatorial regions in the phage display library include at least one in-frame amber codon. Further embodiments of the present disclosure pertain to the formed phage display libraries. Additional embodiments of the present disclosure pertain to methods of selecting peptides or proteins that bind to a desired target (e.g., a ligand binding site of a desired target) by utilizing the phage display libraries of the present disclosure. Further embodiments of the present disclosure pertain to peptides that have been screened from the phage display libraries and methods of the present disclosure, such as inhibitors of sirtuin 2, or inhibitors of ENL. |
| FILED | Wednesday, March 04, 2020 |
| APPL NO | 17/436494 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1037 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220259774 | Baughman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Ray H. Baughman (Dallas, Texas); Jiuke Mu (Plano, Texas); Monica Jung De Andrade (Dallas, Texas); Shaoli Fang (Richardson, Texas); Na Li (Dallas, Texas); Carter S. Haines (Murphy, Texas) |
| ABSTRACT | Sheath-run artificial muscles (or SRAMs) are described in which the dimensional changes and/or modulus changes of a sheath on the surface of a twisted or coiled host yarn or fiber drives torsional and tensile actuation. The sheath-core artificial muscle includes a sheath on a coiled core yarn or fiber that has inserted twist, in which the sheath does not include a yarn, the coiled core yarn or fiber includes a core yarn or fiber, the sheath can change volume, modulus, or a combination thereof when actuated by an influence source to drive actuation, and the influence source is selected from a group consisting of absorption processes, desorption processes, changes in temperature, changes in external pressure, changes in a magnetic field, changes in an electric field, exposures to actinic radiation, electrochemical charge and discharge, chemical reactions, and combinations thereof. These sheath-run muscles can be used for diverse applications, such as robots, robotic devices, energy harvesters, muscles that enable electrical energy harvesting, comfort-adjusting textiles, comfort-adjusting clothing, bio-powered intelligent muscles that control the release of drugs, muscles for appropriate drug delivery, intelligent muscles that sense their environment and actuate in response, muscles for artificial limbs and orthotic gloves, muscles for haptic applications, muscles that can perform in extreme environments, and muscles for intelligent solar panel positioning. |
| FILED | Thursday, May 07, 2020 |
| APPL NO | 17/610045 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/08 (20130101) A61F 2002/0894 (20130101) Crimping or Curling Fibres, Filaments, Threads, or Yarns; Yarns or Threads D02G 3/36 (20130101) Original (OR) Class D02G 3/448 (20130101) Spring, Weight, Inertia or Like Motors; Mechanical-power Producing Devices or Mechanisms, Not Otherwise Provided for or Using Energy Sources Not Otherwise Provided for F03G 7/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220260062 | Li et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| INVENTOR(S) | Na Li (Richardson, Texas); Carter S. Haines (Murphy, Texas); Marcio D. Lima (Richardson, Texas); Monica Jung DeAndrade (Richardson, Texas); Shaoli Fang (Richardson, Texas); Jiyoung Oh (Richardson, Texas); Mikhail E. Kozlov (Dallas, Texas); Dongseok Suh (Plano, Texas); Ray H. Baughman (Dallas, Texas) |
| ABSTRACT | Actuators (artificial muscles) comprising twisted polymer fibers generate tensile actuation when powered thermally. In some embodiments, the thermally-powered polymer fiber tensile actuator can be incorporated into an article, such as a textile or garment. |
| FILED | Monday, October 18, 2021 |
| APPL NO | 17/504305 |
| CURRENT CPC | Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/0007 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 6/00 (20130101) Spinning or Twisting D01H 1/10 (20130101) Crimping or Curling Fibres, Filaments, Threads, or Yarns; Yarns or Threads D02G 3/02 (20130101) D02G 3/26 (20130101) D02G 3/448 (20130101) Braiding or Manufacture of Lace, Including Bobbin-net or Carbonised Lace; Braiding Machines; Braid; Lace D04C 1/02 (20130101) Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles D10B 2401/046 (20130101) D10B 2401/061 (20130101) D10B 2509/00 (20130101) Spring, Weight, Inertia or Like Motors; Mechanical-power Producing Devices or Mechanisms, Not Otherwise Provided for or Using Energy Sources Not Otherwise Provided for F03G 7/06 (20130101) Original (OR) Class Electric Machines Not Otherwise Provided for H02N 10/00 (20130101) H02N 11/006 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/2925 (20150115) Y10T 428/249921 (20150401) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 20220258625 | Hill et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Proterra Operating Company, Inc. (Burlingame, California) |
| ASSIGNEE(S) | Proterra Operating Company, Inc. (Burlingame, California) |
| INVENTOR(S) | Dale Hill (New Braunfels, Texas); Michael Walker (Dale City, California); Joshua Goldman (San Diego, California); John Horth (Evergreen, Colorado) |
| ABSTRACT | This disclosure provides systems and methods for charging a vehicle. A vehicle and charging station can be designed such that an electric or hybrid vehicle can operate in a fashion similar to a conventional vehicle by being opportunity charged throughout a known route. |
| FILED | Monday, May 02, 2022 |
| APPL NO | 17/661680 |
| CURRENT CPC | Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 5/005 (20130101) B60L 5/42 (20130101) B60L 53/11 (20190201) B60L 53/14 (20190201) Original (OR) Class B60L 53/30 (20190201) B60L 53/31 (20190201) B60L 53/32 (20190201) B60L 53/35 (20190201) B60L 2200/18 (20130101) B60L 2200/26 (20130101) Power Supply Lines, and Devices Along Rails, for Electrically- Propelled Vehicles B60M 7/003 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 7/007 (20130101) H02J 7/0042 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 10/70 (20130101) Y02T 10/7072 (20130101) Y02T 90/12 (20130101) Y02T 90/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220260380 | Trancik et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jessika E. Trancik (Somerville, Massachusetts); Zachary A. Needell (Cambridge, Massachusetts); James McNerney (Somerville, Massachusetts) |
| ABSTRACT | A system for estimating or predicting energy consumption for a trip of a personal vehicle includes a user facing portion and a back-end portion. The user facing portion includes a display and a user interface hosting a real-time application configured to receive travel information and present a received energy distribution via the display. The back-end portion includes a back-end database and an energy processor configured to access the back-end database. The energy processor includes a demand model module configured to produce a set of possible velocity histories and a set of possible ambient temperatures. A vehicle model module is configured to receive the velocity histories and ambient temperatures to provide the energy distribution or a probabilistic prediction of future energy consumption to the user facing portion. |
| FILED | Thursday, May 05, 2022 |
| APPL NO | 17/737083 |
| CURRENT CPC | Arrangement or Mounting of Propulsion Units or of Transmissions in Vehicles; Arrangement or Mounting of Plural Diverse Prime-movers in Vehicles; Auxiliary Drives for Vehicles; Instrumentation or Dashboards for Vehicles; Arrangements in Connection With Cooling, Air Intake, Gas Exhaust or Fuel Supply of Propulsion Units in Vehicles B60K 35/00 (20130101) B60K 37/02 (20130101) Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/3469 (20130101) Original (OR) Class Electric Digital Data Processing G06F 16/90 (20190101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/04 (20130101) G06Q 10/06 (20130101) G06Q 10/0631 (20130101) G06Q 10/06315 (20130101) G06Q 50/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20220257722 | Kaunitz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government As Represented By The Department of Veterans Affairs (Washington, District of Columbia); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan D. Kaunitz (Santa Monica, California); Yasutada Akiba (Santa Monica, California); Suwan Oh (Los Angeles, California) |
| ABSTRACT | The disclosure relates to compositions and methods of suppressing or preventing systemic organ inflammation or multi organ failure in a human patient with acute illnesses, including but not limited to burns, major surgery, sepsis, autoimmune disorders, vasculitis, thromboembolism, trauma, and acute pancreatitis. The method comprises administering to a patient in need of treatment an effective amount of a glucagon-like peptide-2 or an analog thereof. |
| FILED | Friday, March 27, 2020 |
| APPL NO | 17/442831 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/26 (20130101) Original (OR) Class Peptides C07K 14/605 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220260660 | Ennis et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); The United States of America as represented by The Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel B. Ennis (Palo Alto, California); Matthew J. Middione (St. George, Utah); Julio A. Oscanoa Aida (Stanford, California); Shreyas S. Vasanawala (Stanford, California) |
| ABSTRACT | A method for phase-contrast magnetic resonance imaging (PC-MRI) acquires undersampled PC-MRI data using a magnetic resonance imaging scanner and reconstructs MRI images from the undersampled PC-MRI data by reconstructing a first flow-encoded image using a first convolutional neural network, reconstructing a complex difference image using a second convolutional neural network, combining the complex difference image and the first flow-encoded image to obtain a second flow-encoded image, and generating a velocity encoded image from the first flow-encoded image and second flow-encoded image using phase difference processing. |
| FILED | Wednesday, February 16, 2022 |
| APPL NO | 17/673003 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0263 (20130101) A61B 5/7267 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/5608 (20130101) G01R 33/5635 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/0454 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20220257236 | Khanicheh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | EnVision Endoscopy, Inc. (Somerville, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Azadeh Khanicheh (Somerville, Massachusetts); Isaac Ostrovsky (Wellesley, Massachusetts) |
| ABSTRACT | Provided herein is an endoscopic suturing system configured for attachment to, and use with, an endoscope. |
| FILED | Monday, June 21, 2021 |
| APPL NO | 17/353471 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/00087 (20130101) A61B 17/0469 (20130101) Original (OR) Class A61B 2017/00296 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220263818 | Corella |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Francisco Corella (Sacramento, California) |
| ASSIGNEE(S) | Pomian and Corella LLC (Sacramento, California) |
| INVENTOR(S) | Francisco Corella (Sacramento, California) |
| ABSTRACT | A method is provided for remote identification of a subject to a verifier using a third-party cryptographic credential. To create the credential, JavaScript code originating from the credential issuer generates a key pair using a cryptographic library, the Web Cryptography API or a FIDO2 authenticator, obtains from the issuer a disclosable portion of the credential containing the public key and subject attributes, and registers a service worker with the browser. To identify the subject, the verifier redirects a login request to a URL in the scope of the service worker, which intercepts the redirected request and dynamically generates a credential presentation page that sends the disclosable portion of the credential to the verifier and proves knowledge of the private key. |
| FILED | Tuesday, April 19, 2022 |
| APPL NO | 17/723489 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/3239 (20130101) H04L 9/3268 (20130101) H04L 63/083 (20130101) H04L 63/126 (20130101) H04L 63/205 (20130101) H04L 63/0823 (20130101) H04L 63/0861 (20130101) Original (OR) Class H04L 2463/082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Classified Government Agency
| US 20220263287 | Thompson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BAE SYSTEMS Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| ASSIGNEE(S) | BAE SYSTEMS Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| INVENTOR(S) | David E Thompson (Nashua, New Hampshire); Gerard J. Pelletier (Amherst, New Hampshire); Glenn Sindledecker (Dracut, Massachusetts) |
| ABSTRACT | The system and method for cooling a laser using a split liquid cooled heat exchanger. The temperature of coolant entering the system is applied to a portion of the system most in need of lower temperatures and a second heat exchanger uses the outflow from the first heat exchanger to cool a remaining portion of the system that has a tolerance for higher temperatures. The laser cooling system is compact, e.g., less than 45 cubic inches and can handle thermal loads of about 800 W. |
| FILED | Monday, February 15, 2021 |
| APPL NO | 17/175773 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/473 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/041 (20130101) H01S 5/02415 (20130101) H01S 5/02423 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20220260782 | Srinivasan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland); Government of the United States of America, as Represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kartik Srinivasan (Rockville, Maryland); Xiyuan Lu (Montgomery Village, Maryland) |
| ABSTRACT | An optical cavity includes a ring defining an internal boundary and an external boundary, at least one of which is periodically modulated to define a gear-shaped configuration including a plurality of teeth, thereby enabling a plurality of slow-light modes. At least one physical defect may be defined within the periodically modulated internal boundary and/or external boundary to thereby enable at least one localized mode. At least one waveguide is coupled to the ring. |
| FILED | Thursday, February 17, 2022 |
| APPL NO | 17/674079 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 20/00 (20130101) Optical Elements, Systems, or Apparatus G02B 6/122 (20130101) G02B 6/12007 (20130101) G02B 6/29338 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20220263818 | Corella |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Francisco Corella (Sacramento, California) |
| ASSIGNEE(S) | Pomian and Corella LLC (Sacramento, California) |
| INVENTOR(S) | Francisco Corella (Sacramento, California) |
| ABSTRACT | A method is provided for remote identification of a subject to a verifier using a third-party cryptographic credential. To create the credential, JavaScript code originating from the credential issuer generates a key pair using a cryptographic library, the Web Cryptography API or a FIDO2 authenticator, obtains from the issuer a disclosable portion of the credential containing the public key and subject attributes, and registers a service worker with the browser. To identify the subject, the verifier redirects a login request to a URL in the scope of the service worker, which intercepts the redirected request and dynamically generates a credential presentation page that sends the disclosable portion of the credential to the verifier and proves knowledge of the private key. |
| FILED | Tuesday, April 19, 2022 |
| APPL NO | 17/723489 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/3239 (20130101) H04L 9/3268 (20130101) H04L 63/083 (20130101) H04L 63/126 (20130101) H04L 63/205 (20130101) H04L 63/0823 (20130101) H04L 63/0861 (20130101) Original (OR) Class H04L 2463/082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of the Interior (DOI)
| US 20220259463 | Zhao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xuanhe Zhao (Allston, Massachusetts); Hyunwoo Yuk (Cambridge, Massachusetts); Heejung Roh (Cambridge, Massachusetts) |
| ABSTRACT | A dry shape memory adhesive material for adhering a target surface in the presence of fluid and for providing tunable mechanical contraction of an adhered surface. The dry shape memory adhesive material is pre-stretched and dried to provide an adhesive structure that implements a hydration-based shape memory mechanism to achieve both uniaxial and biaxial contractions of the adhered surface. According to preferred embodiments, the shape memory adhesive material includes a combination of one or more hydrophilic polymers or copolymers, one or more amine coupling group, and one or more cross linkers. |
| FILED | Tuesday, February 08, 2022 |
| APPL NO | 17/666642 |
| CURRENT CPC | Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 7/25 (20180101) C09J 7/32 (20180101) Original (OR) Class C09J 2301/12 (20200801) C09J 2301/306 (20200801) C09J 2301/414 (20200801) C09J 2405/00 (20130101) C09J 2433/00 (20130101) C09J 2475/006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Office of the Director of National Intelligence (ODNI)
| US 20220261603 | Ardulov et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | HRL Laboratories, LLC (Malibu, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Victor Ardulov (Long Beach, California); Aruna Jammalamadaka (Camarillo, California); Tsai-Ching Lu (Thousand Oaks, California) |
| ABSTRACT | Described is a system for learning and predicting key phrases. The system learns based on a dataset of historical forecasting questions, their associated time-series data for a quantity of interest, and associated keyword sets. The system learns the optimal policy of actions to take given the associated keyword sets and the optimal set of keywords which are predictive of the quantity of interest. Given a new forecasting question, the system extracts an initial keyword set from a new forecasting question, which are perturbed to generate an optimal predictive key-phrase set. Key-phrase time-series data are extracted for the optimal predictive key-phrase set, which are used to generate a forecast of future values for a value of interest. The forecast can be used for a variety of purposes, such as advertising online. |
| FILED | Wednesday, April 27, 2022 |
| APPL NO | 17/730957 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/907 (20190101) G06F 16/90335 (20190101) G06F 40/40 (20200101) G06F 40/166 (20200101) G06F 40/205 (20200101) G06F 40/284 (20200101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6289 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 20/00 (20190101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 30/0202 (20130101) G06Q 30/0255 (20130101) G06Q 50/01 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20220264256 | JOHNSON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey C. JOHNSON (Annapolis, Maryland); Leonetta J. JACKSON (Dublin, California); Srinivasa R. CHAPPIDI (Cupertino, California); Dongni S. GROWNEY (Belmont, California); Bijai T. NIDHIRI (Fremont, California); Danny TAN (San Francisco, California); Jini J. THOKALATH (Foster City, California); Gang YIN (Fremont, California) |
| ABSTRACT | Techniques for tracking an evacuation of a location in an environment that utilizes physical tokens to prove physical presence at the location are presented. The techniques include receiving data representing of subordinates of an evacuation facilitator; receiving physical token based location status information for at least one of the subordinates, where the physical token based location status information is based on electronic readings of the physical tokens; determining based on the physical token based location status information, a physical presence status at the location for the at least one of the subordinates; receiving evacuation status information for each of the at least one of the subordinates that has a physical presence status that indicates a presence at the location; and recording the evacuation status information for each of the at least one of the subordinates that has a physical presence status that indicates a presence at the location. |
| FILED | Thursday, May 05, 2022 |
| APPL NO | 17/737613 |
| CURRENT CPC | Wireless Communication Networks H04W 4/12 (20130101) H04W 4/021 (20130101) H04W 4/029 (20180201) Original (OR) Class H04W 4/90 (20180201) H04W 12/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20220260017 | Seppala et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin Johannes Seppala (Madeira, Ohio); Kenneth Jay Moore (Fairfield Township, Ohio); Thomas Ryan Wallace (Cincinnati, Ohio) |
| ABSTRACT | A gas turbine engine having a fluid transfer connection is provided. The gas turbine engine includes a first component configured to channel a flow of air from a portion of the gas turbine engine; a second component configured to receive the flow of air from the first component, wherein the first component and the second component are movable relative to one another; a sleeve portion disposed between the first component and the second component; and a spoolie device disposed within the sleeve portion, the spoolie device having elliptical shaped opposing ends, wherein the spoolie device bridges the first component and the second component to channel the flow of air from the first component to the second component. |
| FILED | Thursday, February 18, 2021 |
| APPL NO | 17/178429 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 9/06 (20130101) F01D 25/12 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/16 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2260/20 (20130101) F05D 2260/60 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220264007 | Pilskalns |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SKYYFISH LLC (Stevensville, Montana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Orest Jacob Pilskalns (Missoula, Montana) |
| ABSTRACT | Simultaneous control of an unmanned vehicle and an on-board sensor is facilitated by the use of an intelligent gimbal assembly. The assembly includes a gimbal for carrying the sensor and a node controller for controlling the gimbal, sensor and the unmanned vehicle to which the gimbal assembly is attached. The node controller controls the flight or navigation controller of the unmanned vehicle via an application programming interface in the vehicle. The node controller can include drivers for controlling different vehicles and different gimbals. |
| FILED | Saturday, April 30, 2022 |
| APPL NO | 17/734021 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 39/024 (20130101) B64C 2201/127 (20130101) B64C 2201/141 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 47/08 (20130101) Traffic Control Systems G08G 5/003 (20130101) G08G 5/0069 (20130101) Pictorial Communication, e.g Television H04N 5/2252 (20130101) H04N 5/23258 (20130101) Original (OR) Class H04N 5/23264 (20130101) H04N 5/225251 (20180801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220264745 | Favreau et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | RAYTHEON COMPANY (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Channing Paige Favreau (Barre, Massachusetts); James E. Benedict (Lowell, Massachusetts); Mikhail Pevzner (Woburn, Massachusetts); Thomas V. Sikina (Acton, Massachusetts) |
| ABSTRACT | A method of fabricating a printed circuit assembly includes providing a flexible-hybrid circuit having a base and at least one side panel. The at least one side panel is hingedly connected to the base. The method further includes disposing a support structure on the flexible-hybrid circuit. The support structure includes a base, which is disposed on the base of the flexible-hybrid circuit, and at least one side that corresponds to the at least one side panel of the flexible-hybrid circuit. The method further includes folding the at least one side panel of the flexible-hybrid circuit so that the at least one side panel is disposed co-planar with the at least one side of the support structure to create a printed circuit assembly. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/174904 |
| CURRENT CPC | Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/028 (20130101) H05K 1/118 (20130101) Original (OR) Class H05K 3/326 (20130101) H05K 3/4691 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, August 18, 2022.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20220818.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page