FedInvent™ Patent Applications
Application Details for Thursday, September 29, 2022
This page was updated on Thursday, September 29, 2022 at 03:33 PM GMT
Department of Health and Human Services (HHS)
| US 20220304285 | Winslow et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Monte Winslow (Stanford, California); Dmitri Petrov (Stanford, California); Ian Winters (Stanford, California); Christopher McFarland (Davis, California); Zoe Rogers (Menlo Park, California) |
| ABSTRACT | Compositions and methods are provided for measuring population size for a plurality of clonal cell populations in the same individual, e.g., for measuring tumor size for a plurality of clonally independent tumors within the same individual. A subject method can include: (a) contacting an individual with a plurality of cell markers that are heritable and distinguishable from one another, to generate a plurality of distinguishable lineages of heritably marked cells; (b) after sufficient time has passed for the heritably marked cells to undergo at least one round of division, detecting and measuring quantities of at least two of the plurality of cell markers present in the contacted tissue, thereby generating a set of measured values: and (c) using the set of measured values to calculate the number of heritably marked cells that are present (e.g., for at least two of the distinguishable lineages of heritably marked cells). |
| FILED | Tuesday, October 01, 2019 |
| APPL NO | 17/281919 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0275 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/86 (20130101) C12N 15/1065 (20130101) C12N 2310/20 (20170501) C12N 2750/14142 (20130101) C12N 2800/80 (20130101) C12N 2830/002 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) C12Q 1/6886 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5011 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220304286 | Breunig et al. |
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| FUNDED BY |
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| APPLICANT(S) | CEDARS-SINAI MEDICAL CENTER (Los Angeles, California) |
| ASSIGNEE(S) | CEDARS-SINAI MEDICAL CENTER (Los Angeles, California) |
| INVENTOR(S) | Joshua Breunig (Beverly Hills, California); Moise Danielpour (Los Angeles, California); Gi Bum Kim (North Hollywood, California); Alberto Ayala-Sarmiento (Hawthorne, California); Amy Yang (Los Angeles, California) |
| ABSTRACT | Described herein are donor vectors and systems for use in dual recombinase-mediated cassette exchange. Also described herein are animal models and human cells for consistent, rigorous, and facile investigation of transgene expression. Further described herein are methods of screening for therapeutic drugs using these animal models, and methods of treatment. |
| FILED | Tuesday, June 16, 2020 |
| APPL NO | 17/617878 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0275 (20130101) Original (OR) Class A01K 2217/15 (20130101) A01K 2217/052 (20130101) A01K 2217/054 (20130101) A01K 2217/206 (20130101) A01K 2227/105 (20130101) A01K 2267/0331 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 15/90 (20130101) C12N 15/102 (20130101) C12N 2750/14143 (20130101) C12N 2800/30 (20130101) C12N 2800/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220304307 | Yang et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Liu Yang (Gainesville, Florida); Gary Richoux (Gainesville, Florida); Edmund J. Norris (Gainesville, Florida); Jeffrey R. Bloomquist (Gainesville, Florida) |
| ABSTRACT | The subject matter described herein is directed to compounds, synergistic compositions, and methods for repelling arthropods. The compositions comprise acids, esters, aldehydes, or alcohols of pyrethroid-type compounds. The compounds, particularly the pyrethroid-type acids, demonstrate excellent repellency when applied both alone and in synergistic compositions. |
| FILED | Thursday, July 30, 2020 |
| APPL NO | 17/630843 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 53/00 (20130101) Original (OR) Class Acyclic or Carbocyclic Compounds C07C 69/743 (20130101) C07C 2601/02 (20170501) C07C 2601/04 (20170501) C07C 2601/08 (20170501) C07C 2601/14 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220304588 | Partanen et al. |
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| APPLICANT(S) | University of Washington (Seattle, Washington); Koninlkijke Philips N.V., a corporation organized and existing under the laws of Kingdom of the Net (AE Eindhoven, Netherlands) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ari Ilkka Mikael Partanen (Andover, Massachusetts); Wayne Kreider (Seattle, Washington); Vera Khokhlova (Seattle, Washington) |
| ABSTRACT | Disclosed herein are example embodiments of devices, systems, and methods for mechanical fractionation of biological tissue using magnetic resonance imaging (MRI) feedback control. The examples may involve displaying an image representing first MRI data corresponding to biological tissue, and receiving input identifying one or more target regions of the biological tissue to be mechanically fractionated via exposure to first ultrasound waves. The examples may further involve applying the first ultrasound waves and, contemporaneous to or after applying the first ultrasound waves, acquiring second MRI data corresponding to the biological tissue. The examples may also involve determining, based on the second MRI data, one or more second parameters for applying second ultrasound waves to the biological tissue, and applying the second ultrasound waves to the biological tissue according to the one or more second parameters. |
| FILED | Monday, December 06, 2021 |
| APPL NO | 17/543276 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/01 (20130101) A61B 5/02 (20130101) A61B 5/0035 (20130101) A61B 5/055 (20130101) Original (OR) Class A61B 2090/374 (20160201) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 7/02 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/50 (20130101) G01R 33/4814 (20130101) G01R 33/5602 (20130101) G01R 33/56341 (20130101) G01R 33/56358 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220304596 | Zhang et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Xuezhu Zhang (Davis, California); Jinyi Qi (Davis, Canada); Simon R. Cherry (Davis, California); Ramsey D. Badawi (Sacramento, California); Guobao Wang (Sacramento, California) |
| ABSTRACT | The disclosed embodiments relate to a system that performs ultra-fast tracer imaging on a subject using positron emission tomography. During operation, the system performs a high-temporal-resolution, total-body dynamic PET scan on the subject as an intravenously injected radioactive tracer propagates through the vascular system of the subject to produce PET projection data. Next, the system applies an image reconstruction technique to the PET projection data to produce subsecond temporal frames, which illustrate the dynamic propagation of the radioactive tracer through the vascular system of the subject. Finally, the system outputs the temporal frames through a display device. |
| FILED | Thursday, July 16, 2020 |
| APPL NO | 17/619471 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/113 (20130101) A61B 5/1128 (20130101) Original (OR) Class A61B 5/02755 (20130101) A61B 5/7289 (20130101) A61B 6/037 (20130101) A61B 6/486 (20130101) Measurement of Nuclear or X-radiation G01T 1/2985 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220304725 | Gage et al. |
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| FUNDED BY |
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| APPLICANT(S) | INNAVASC MEDICAL, INC. (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shawn M. Gage (Raleigh, North Carolina); John Lucas (Greenwood, Mississippi); Craig Nichols (Durham, North Carolina); Joseph Knight (Durham, North Carolina); Juan Chiossone (Raleigh, North Carolina); Peter Lawson (Durham, North Carolina); Samantha Busch (Indian Land, South Carolina); Brian Walsh (Charlotte, North Carolina) |
| ABSTRACT | An apparatus for delivery of a vascular arteriovenous graft comprises a tubular sleeve defining an interior lumen adapted for being slidably positioned over a tunneling instrument. Once the tunneling instrument has been advanced to a desired subcutaneous anatomical location the shaft is removed while the sleeve remains in the tissue. The sleeve has a linear slit extending from a proximal end to a point intermediate the length of the sleeve. The lumen receives the distal end of the graft and at least a portion of a cannulation chamber such that the end of the sleeve progressively expands along the slit to provide an enlarged diameter for accommodating the cannulation chamber. Longitudinal force to the sleeve during removal of the sleeve from the tissue secures the graft in the sleeve by radial compression of the sleeve for pulling the graft and the sleeve through the tunnel and deploying the vascular graft. |
| FILED | Thursday, December 30, 2021 |
| APPL NO | 17/566433 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/3468 (20130101) Original (OR) Class Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/3655 (20130101) A61M 1/3661 (20140204) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220304928 | BUTTE et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Manish J. BUTTE (Los Angeles, California); Mohammad Mahdi HASANI-SADRABADI (Los Angeles, California); Fatemeh S. MAJEDI (Los Angeles, California) |
| ABSTRACT | Synthetic liposomal nanoparticles comprising a cell-free transcription and translation machinery, a plasmid encoding a cytokine, and a regulatable caged ATP molecule, as well as microparticles encasing the synthetic liposomal nanoparticles and methods of making and using the synthetic liposomal nanoparticles, are described herein. These liposomal nanoparticles may be used for the controlled release o a cytokine within a localized environment of, for example a tumor, as part of a therapeutic treatment of cancer, or for localized treatment at a focus of interest of an autoimmune disease, an allergic reaction or hypersensitivity reaction, a localized site of an infection or infectious disease, a localized site of an injury or other damage, a transplant or other surgical site, or a blood clot. Further, microparticles produced by encapsulating hundreds of liposomal nanoparticles, and their therapeutic uses, are also described. |
| FILED | Friday, September 18, 2020 |
| APPL NO | 17/639803 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/127 (20130101) Original (OR) Class A61K 9/1277 (20130101) A61K 9/4866 (20130101) A61K 9/5015 (20130101) A61K 35/17 (20130101) A61K 38/2013 (20130101) A61K 41/0042 (20130101) A61K 48/0025 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) A61P 17/02 (20180101) A61P 31/04 (20180101) A61P 35/00 (20180101) A61P 37/06 (20180101) A61P 37/08 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220304945 | GUDAS et al. |
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| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | Cornell University (Ithaca, New York) |
| INVENTOR(S) | Lorraine J GUDAS (New York, New York); Yannick BENOIT (Ontario, Canada); Ronald PEREZ (Somerset, New Jersey); Xiao-Han TANG (Staten Island, New York); Steven TRASINO (Brooklyn, New York) |
| ABSTRACT | This invention relates to pharmaceutical compositions and methods for treating (including managing) or preventing metabolic syndrome related conditions using one or more RARβ (e.g., RARβ2) agonists. Such conditions include, but are not limited to, diseases in pancreas, liver, kidney, testes, muscle, or adipose tissue, as well as other organs that are associated with high fat diet and/or vitamin A deficiency, as well as other conditions associated with abnormal level of triglyceride, cholesterol and/or glucose. |
| FILED | Monday, November 01, 2021 |
| APPL NO | 17/515796 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/07 (20130101) Original (OR) Class A61K 31/192 (20130101) A61K 31/426 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) A61P 3/04 (20180101) A61P 3/06 (20180101) A61P 3/10 (20180101) A61P 9/00 (20180101) A61P 13/12 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220304957 | Reiss et al. |
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| APPLICANT(S) | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana); University of New Orleans (New Orleans, Louisiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Krzysztof Reiss (Metairie, Louisiana); Branko Jursic (New Orleans, Louisiana) |
| ABSTRACT | This invention is directed to anticancer compounds, pharmaceutical compositions comprising the same, methods of making anticancer compounds, and methods of treating cancer with compounds and pharmaceutical compositions. |
| FILED | Monday, January 13, 2020 |
| APPL NO | 17/421980 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/47 (20130101) A61K 31/165 (20130101) Original (OR) Class A61K 31/426 (20130101) A61K 31/473 (20130101) A61K 31/495 (20130101) A61K 31/4965 (20130101) A61K 31/5377 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220304992 | Blau et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Helen M. Blau (Stanford, California); Adelaida Rosa Palla (Stanford, California); Andrew Tri Van Ho (Paris, France) |
| ABSTRACT | The present disclosure provides compositions and methods based on the identification of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) as a therapeutic target in aging, dystrophic muscle to improve muscle atrophy, increase muscle mass, function and strength. Further provided herein are compositions and methods for the rejuvenation of aged tissue. In particular, 15-PGDH inhibitors, such as SW033291, are used to elevate the levels of prostaglandin E2 (PGE2) in the muscle or tissue. |
| FILED | Thursday, June 11, 2020 |
| APPL NO | 17/616966 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4365 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220305013 | SHOICHET et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (Toronto, Canada); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, None) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Molly S. SHOICHET (Toronto, Canada); Ahil N. GANESH (Richmond Hill, Canada); Eric N. DONDERS (Deep River, Canada); Brian K. SHOICHET (San Francisco, California); Hayarpi TOROSYAN (San Francisco, California) |
| ABSTRACT | The present application provides a colloid drug aggregate composition and methods of use and manufacture thereof. While the formation of colloidal aggregates leads to artifacts in early drug discovery, their composition makes them attractive as nanoparticle formulations for targeted drug delivery. The present application provides an acid-responsive composition comprising: a colloidal aggregate of one or more drugs and a stabilizing agent, wherein the colloidal aggregate disrupts, dissolves or disassembles when the acid-responsive composition is in an acid environment having a pH of less than 7.4. The colloidal aggregate of the composition will disassemble upon contact with acid or upon introduction to an acidic environment, such as is found in the endosomes of cells. This approach makes this composition an attractive vehicle for drug delivery to a target site in a subject or to cells. |
| FILED | Thursday, June 18, 2020 |
| APPL NO | 17/619837 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/10 (20130101) A61K 31/44 (20130101) A61K 31/438 (20130101) A61K 31/506 (20130101) Original (OR) Class A61K 31/566 (20130101) A61K 31/4174 (20130101) A61K 47/28 (20130101) A61K 47/34 (20130101) A61K 47/42 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220305016 | Wein et al. |
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| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts); The Broad Institute, Inc. (Cambridge, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | The General Hospital Corporation (Boston, Massachusetts); The Broad Institute, Inc. (Cambridge, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Marc Wein (Boston, Massachusetts); Henry Kronenberg (Boston, Massachusetts); Thomas Sundberg (Boston, Massachusetts); Ramnik Xavier (Brookline, Massachusetts); Nathanael S. Gray (Stanford, California); Yanke Liang (Belmont, Massachusetts); Hwan Geun Choi (Chestnut Hill, Massachusetts); Alykhan Shamji (Somerville, Massachusetts) |
| ABSTRACT | The present disclosure provides methods of treating and/or preventing osteoporosis using salt-inducible kinase (SIK) inhibitors. Also provided are methods of using SIK inhibitors for increasing the function of osteocytes, increasing the number of osteoblasts, increasing the activity of osteoblasts, inhibiting the resorption of a bone, decreasing the number of osteoclasts, inhibiting the activity of osteoclasts, increasing the mass of a bone, down-regulating the expression of the gene SOST, and/or inhibiting the activity of sclerostin. The SIK inhibitors may be combined with Src inhibitors or CSF I R inhibitors. Exemplary SIK inhibitors include the compounds of the formula: (I), (II), (III), (IV), (V) or (VI). |
| FILED | Friday, January 21, 2022 |
| APPL NO | 17/581818 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220305024 | Boss et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gerard Boss (La Jolla, California); Darren Casteel (La Jolla, California); Hema Rangaswami (La Jolla, California); Renate Pilz (La Jolla, California) |
| ABSTRACT | Compositions and methods for treatment of aortic disease in a subject in need comprising an effective amount of cobinamide. Aortic diseases include for example aortic aneurysm, aortic dissection, or aortic dilation. Aortic disease can be caused for example by Marfan syndrome or oxidative stress. |
| FILED | Wednesday, June 03, 2020 |
| APPL NO | 17/616122 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/555 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220305025 | BANKERT et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for The State University of New York (Amherst, New York); Molecular Targeting Technologies, Inc. (West Chester, Pennsylvania); Immune Modulatory Therapies LLC (Eden, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard B. BANKERT (Eden, New York); Koon Yan PAK (Malvern, Pennsylvania); Brian D. GRAY (Exton, Pennsylvania); Sathy V. BALU-IYER (Amherst, New York); Raymond KELLEHER (Amherst, New York); Gautam SHENOY (Amherst, New York); Maulasri BHATTA (Buffalo, New York) |
| ABSTRACT | The present disclosure provides compounds that bind phosphatidylserine (PS). Also provided are compositions comprising the compounds and methods of using the compounds and/or compositions. The compounds and compositions may be used to treat an individual having or suspected of having cancer(s), infectious disease(s), chronic inflammation, and/or autoimmune condition(s). |
| FILED | Monday, August 17, 2020 |
| APPL NO | 17/635673 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/127 (20130101) A61K 31/555 (20130101) Original (OR) Class A61K 39/3955 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 3/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220305031 | GLAZER et al. |
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| APPLICANT(S) | GEORGETOWN UNIVERSITY (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert I. GLAZER (Potomac, Maryland); Moshe LEVI (Washington, District of Columbia); Hongyan YUAN (Damascus, Maryland); Suman RANJIT (Arlington, Virginia) |
| ABSTRACT | Aspects of the technology described herein relate to a method of treating a malignancy in a subject. This method involves selecting a subject having a malignancy and administering dimethyl-3-beta-hydroxy-cholenamide (DMHCA) or derivative thereof to the subject in an amount effective to treat the malignancy. Methods of reducing malignancy-associated fibrosis in a subject and pharmaceutical combinations comprising (i) DMHCA or derivative thereof and (ii) one or more immune checkpoint inhibitors are also disclosed. |
| FILED | Thursday, June 11, 2020 |
| APPL NO | 17/618302 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/282 (20130101) A61K 31/337 (20130101) A61K 31/475 (20130101) A61K 31/513 (20130101) A61K 31/575 (20130101) Original (OR) Class A61K 31/675 (20130101) A61K 31/704 (20130101) A61K 31/5545 (20170801) A61K 31/7068 (20130101) A61K 33/243 (20190101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20220305043 — FORMULATIONS OF CYCLIC MACROMOLECULE-BASED NANOPARTICLES ENCAPSULATING SMALL MOLECULES
| US 20220305043 | Chaudhuri et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Regents of The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | Board of Regents of The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Sauradip Chaudhuri (Houston, Texas); Rachael Sirianni (Sugar Land, Texas) |
| ABSTRACT | In an embodiment, the present disclosure pertains to a composition. In some embodiments, the composition includes a cross-linked network of cyclic macromolecules. In some embodiments, the cyclic macromolecules are covalently cross-linked to one another by a plurality of cross-linking agents. In some embodiments, at least some of the cross-linking agents are covalently functionalized with a plurality of functional groups. In some embodiments, the plurality of functional groups include a chain of at least three atoms that protrude out of the cross-linking agents. In some embodiments, the cross-linking agents and the functional groups form a polymer matrix, such as poly (β-amino ester). In some embodiments, the composition is in the form of particles. In another embodiment, the present disclosure pertains to a method of administering an active agent to a subject. In some embodiments, the method includes administering a composition of the present disclosure to the subject. |
| FILED | Wednesday, March 25, 2020 |
| APPL NO | 17/613197 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5161 (20130101) A61K 31/506 (20130101) A61K 31/538 (20130101) A61K 31/4045 (20130101) A61K 31/4745 (20130101) A61K 31/7068 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220305044 | Korinek et al. |
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| FUNDED BY |
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| APPLICANT(S) | Astrocyte Pharmaceuticals, Inc. (Cambridge, None); Board of Regents, the University of Texas System (Autin, Texas); The United State of America, as Represented by the Secretary, Department of Health and Human Service (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William S. Korinek (Mystic, Connecticut); James D. Lechleiter (San Antonio, Texas); Theodore E. Liston (Stonington, Connecticut); Kenneth A. Jacobson (Silver Spring, Maryland) |
| ABSTRACT | The present invention relates to compounds and methods of use thereof for treatment of certain disorders and conditions, for example brain injuries such as stroke or traumatic brain injuries. |
| FILED | Friday, April 21, 2017 |
| APPL NO | 16/095282 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7076 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220305048 | Sundararaman et al. |
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| FUNDED BY |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Shriram Sundararaman (Charlottesville, Virginia); Erik Knelson (Brookline, Massachusetts); Shunsuke Kitajima (Allston, Massachusetts); David Barbie (Andover, Massachusetts); Saemi Han (Gwancheon-si, South Korea) |
| ABSTRACT | Disclosed herein are methods for treating a subject having cancer by coadministering a stimulator of interferon signaling and a heparin polysaccharide. Also disclosed herein are pharmaceutical compositions that include a stimulator of interferon signaling and a heparin polysaccharide. |
| FILED | Wednesday, August 26, 2020 |
| APPL NO | 17/638150 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/727 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220305049 | GLASS et al. |
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| FUNDED BY |
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| APPLICANT(S) | TEGA Therapeutics, Inc. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles GLASS (San Diego, California); Bryan THACKER (San Diego, California); Jeffrey D. ESKO (San Diego, California) |
| ABSTRACT | Abstract: Provided herein are methods of producing heparin and heparan sulfate from modified cells, such as modified MST cells and modified basophil neoplastic cells, and compositions comprising heparin and heparan sulfate isolated from modified cells. In some embodiments, methods herein comprise culturing a genetically modified cell line comprising at least one of a mastocytoma cell line and a basophil neoplastic cell line; and isolating the heparin or heparan sulfate from the cell line. |
| FILED | Thursday, August 27, 2020 |
| APPL NO | 17/638760 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/727 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/02 (20180101) A61P 11/00 (20180101) A61P 29/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0693 (20130101) C12N 15/52 (20130101) C12N 15/86 (20130101) C12N 2510/02 (20130101) C12N 2740/15043 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/26 (20130101) Enzymes C12Y 208/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220305051 | Rose et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); The UAB Research Foundation (Birmingham, Alabama) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); The UAB Research Foundation (Birmingham, Alabama) |
| INVENTOR(S) | Jason Joseph Rose (Fox Chapel, Pennsylvania); Mark Thomas Gladwin (Pittsburgh, Pennsylvania); Rakesh P. Patel (Birmingham, Alabama); Sadis Matalon (Birmingham, Alabama) |
| ABSTRACT | Methods for the treatment of lung injury caused by chemical inhalation, smoke inhalation or microbial infection are described. The methods include administering a therapeutically effective amount of nitrite or a nitrite formulation. Nitrite formulations that include a nitrite salt and an anti-caking agent, such as sodium bicarbonate, and the use of such formulations, is also described. |
| FILED | Friday, September 04, 2020 |
| APPL NO | 17/640158 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0053 (20130101) A61K 9/0073 (20130101) A61K 33/00 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) A61P 31/14 (20180101) A61P 39/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220305073 | Palmer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Abraham Palmer (La Jolla, California); Margaret Distler (Los Angeles, California); Katherine M. J. McMurray (Oxford, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Abraham Palmer (La Jolla, California); Margaret Distler (Los Angeles, California); Katherine M. J. McMurray (Oxford, Ohio) |
| ABSTRACT | Methods and compositions are provided for treating or preventing a neurological disease or disorder using an inhibitor of Glyoxalase 1 (GLO1). In some embodiments, the inhibitor is a small molecule. In certain embodiments, the disease or disorder is a sleep disorder, a mood disorder such as depression, epilepsy, an anxiety disorder, substance abuse, substance dependence or substance such as an alcohol withdrawal syndrome. |
| FILED | Monday, January 31, 2022 |
| APPL NO | 17/649464 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/165 (20130101) A61B 5/4023 (20130101) A61B 5/4806 (20130101) A61B 5/4848 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/223 (20130101) A61K 33/00 (20130101) A61K 38/005 (20130101) A61K 38/05 (20130101) Original (OR) Class A61K 38/063 (20130101) A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220305080 | Zhao |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | New York Society for the Relief of the Ruptured and Crippled, Maintaining the Hospital for Special (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Baohong Zhao (New York, New York) |
| ABSTRACT | Provided herein is a method of suppressing osteoclast differentiation or function and/or bone resorption or destruction in a subject in need thereof and compositions therefore. In one embodiment, the method includes increasing the amount, expression, or activity of Foxo3 isoform 2 in the subject. |
| FILED | Friday, August 14, 2020 |
| APPL NO | 17/635594 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/00 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) G01N 2333/4703 (20130101) G01N 2800/50 (20130101) G01N 2800/52 (20130101) G01N 2800/108 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220305083 | Laurie et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | TearSolutions, Inc. (Charlottesville, Virginia); University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gordon W. Laurie (Charlottesville, Virginia); Marc G. Odrich (Crozet, Virginia); Michelle Carpenter (Novato, California); Thomas R. Gadek (Park City, Utah); Paul A. Laskar (Napa, California) |
| ABSTRACT | This application generally relates to stable peptide compositions and kits comprising low levels of buffering and chelating agents, and methods of using the same. |
| FILED | Thursday, November 04, 2021 |
| APPL NO | 17/519489 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) A61K 9/0048 (20130101) A61K 38/18 (20130101) Original (OR) Class A61K 47/02 (20130101) A61K 47/10 (20130101) A61K 47/12 (20130101) A61K 47/14 (20130101) A61K 47/183 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220305088 | ALMEIDA DE PINHO RIBEIRO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts); THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts); THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| INVENTOR(S) | Felipe ALMEIDA DE PINHO RIBEIRO (Cambridge, Massachusetts); Pankaj BARAL (Arlington, Massachusetts); Isaac M. CHIU (Cambridge, Massachusetts); Nicole J. YANG (Cambridge, Massachusetts); Michael WESSELS (Brookline, Massachusetts); Buket BADDAL (Boston, Massachusetts) |
| ABSTRACT | Described herein are methods and compositions for treating and/or preventing a microbial infection. Aspects of the invention relate to administering to a subject an agent that inhibits CGRP release and CGRP receptors. In some embodiments of any of the aspects, a subject has been diagnosed with having, or is at risk of having, a microbial infection. |
| FILED | Thursday, April 14, 2022 |
| APPL NO | 17/720852 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/225 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220305103 | SHEN |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Methodist Hospital (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Haifa SHEN (Bellaire, Texas) |
| ABSTRACT | Disclosed are biocompatible core/shell compositions suitable for the delivery of populations of mRNA molecules to mammalian cells. The disclosed core-shell structured multicomponent compositions are optimized for the delivery of mRNAs encoding one or more cancer- or tumor-specific antigens to a population of antigen presenting cells, including, for example, human dendritic cells, macrophages and B cells. Also disclosed are methods for use of these compositions as therapeutic cancer vaccines. |
| FILED | Tuesday, May 24, 2022 |
| APPL NO | 17/751812 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/127 (20130101) A61K 9/1271 (20130101) A61K 39/0011 (20130101) Original (OR) Class A61K 39/39 (20130101) A61K 39/001104 (20180801) A61K 39/001106 (20180801) A61K 39/001156 (20180801) A61K 45/06 (20130101) A61K 47/645 (20170801) A61K 47/6925 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220305109 | He et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Linling He (San Diego, California); Jiang Zhu (San Diego, California); Anshul Chaudhary (La Jolla, California); Ian Wilson (La Jolla, California) |
| ABSTRACT | The present invention provides novel engineered Ebolavirus GP proteins and polypeptides, scaffolded vaccine compositions that display the engineered proteins, and polynucleotides encoding the engineered proteins and scaffolded vaccine compositions. The invention also provides methods of using such engineered Ebolavirus GP proteins and vaccine compositions in various therapeutic applications, e.g., for preventing or treating Ebolavirus infections. |
| FILED | Thursday, April 07, 2022 |
| APPL NO | 17/715658 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class Peptides C07K 14/473 (20130101) C07K 2317/34 (20130101) C07K 2319/735 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2760/14134 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220305121 | Carson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dennis A. Carson (La Jolla, California); Tomoko Hayashi (San Diego, California); Maripat Corr (San Diego, California); Howard B. Cottam (Escondido, California); Nijunj Shukla (San Diego, California); Michael Chan (San Diego, California) |
| ABSTRACT | Bis-aryl sulfonamide compounds and methods of using those compounds, e.g., in a method of enhancing or prolonging an immune response, are provided. For example, the compounds may be employed with a vaccine and optionally at least one other adjuvant and/or one or more TLR ligands, at least one MAP kinase inhibitor, or any combination thereof. |
| FILED | Saturday, August 15, 2020 |
| APPL NO | 17/635983 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/63 (20130101) A61K 39/39 (20130101) Original (OR) Class A61K 2039/55511 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220305141 | Gersbach et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles A. Gersbach (Chapel Hill, North Carolina); Jennifer Kwon (Durham, North Carolina) |
| ABSTRACT | Disclosed herein are methods and systems for increasing expression of Pax7, methods of activating endogenous myogenic transcription factor Pax7 in a cell, methods of differentiating a stem cell into a skeletal muscle progenitor cell, as well as compositions and methods for treating a subject in need of regenerative muscle progenitor cells. The compositions and methods may include a Cas9-based transcriptional activator protein and at least one guide RNA (gRNA) targeting Pax7. |
| FILED | Wednesday, August 19, 2020 |
| APPL NO | 17/636754 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/34 (20130101) A61K 38/00 (20130101) A61K 48/0058 (20130101) Original (OR) Class Peptides C07K 14/315 (20130101) C07K 14/4702 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/63 (20130101) C12N 15/113 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) C12N 2740/16043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220305176 | Ameer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois); Ann and Robert H. Lurie Children's Hospital of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Guillermo A. Ameer (Chicago, Illinois); Arun K. Sharma (Elmhurst, Illinois); Xinlong Wang (Evanston, Illinois); Matthew I. Bury (Lake Villa, Illinois) |
| ABSTRACT | Provided herein are materials and methods related to scaffolds and uses thereof. In some embodiments, provided herein are poly (octamethylene-octanol citrates) (POOC) scaffolds with native mechanical properties that are comparable to urinary bladder tissue. In some embodiments, provided herein are methods for the synthesis of POOC scaffolds with native mechanical properties that are comparable to urinary bladder tissue by including octanol in the polycondensation synthesis of POC. In some embodiments, provided herein are methods of use of the disclosed scaffolds, including for urinary bladder tissue regeneration. |
| FILED | Monday, August 31, 2020 |
| APPL NO | 17/638905 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) A61L 27/3834 (20130101) Original (OR) Class A61L 2430/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220305281 | Lohr et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Medical College of Wisconsin, Inc. (Milwaukee, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicole Lohr (New Berlin, Wisconsin); Michael Salinger (Milwaukee, Wisconsin) |
| ABSTRACT | Reperfusion injury is limited during endovascular therapies (e.g., revascularization and/or reperfusion of end organ tissues) by conditioning the tissues against reperfusion injury using an optical fiber catheter to deliver far red and near infrared (R/NIR) light to the tissues. The light may be multiple wavelength or single wavelength light, and may have one or more wavelengths selected from the range of 510 to 830 nm. The R/NIR light may be delivered concurrently with the endovascular therapy, or in other instances may be delivered before or after a particular therapy. |
| FILED | Tuesday, March 22, 2022 |
| APPL NO | 17/701099 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 18/24 (20130101) A61B 2018/00351 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/0601 (20130101) Original (OR) Class A61N 5/0613 (20130101) A61N 2005/063 (20130101) A61N 2005/0602 (20130101) A61N 2005/0663 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220305405 | OKEOMA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Research Foundation for The State University of New York (Albany, New York) |
| ASSIGNEE(S) | The Research Foundation for The State University of New York (Albany, New York) |
| INVENTOR(S) | Chioma OKEOMA (Stony Brook, New York); Hussein SADDOUR (Middle Island, New York) |
| ABSTRACT | A method and system are disclosed for isolating intact acellular particles using size exclusion and for obtaining size and concentration of such isolated particles. In one embodiment, the disclosure is directed to use of Particle Purification Liquid Chromatography (PPLC), a high-resolution chromatographic size-guided turbidimetry-enabled system for dye-free isolation, on-line characterization, and retrieval of intact acellular particles, including extracellular vesicles (EVs) and membraneless condensate particles (MCs) from various biofluids. |
| FILED | Friday, May 01, 2020 |
| APPL NO | 17/607960 |
| CURRENT CPC | Separation B01D 15/34 (20130101) Original (OR) Class B01D 15/1871 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/82 (20130101) G01N 30/466 (20130101) G01N 2030/8813 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220305488 | Irimia et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Irimia (Charlestown, Massachusetts); Xiao Wang (Malden, Massachusetts); Irene Scarfo (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein are cell assay devices, methods of assaying the activity of immune cells on target cells, and methods of selecting a treatment for a subject having cancer. Described herein are cell assay devices comprising a biocompatible substrate having an upper surface supporting a plurality of arrays of spots comprising an adhesion-promoting material; a biocompatible membrane having top and bottom surfaces and positioned adjacent to the upper surface of the substrate and defining a plurality of chambers within the membrane between the top surface and the bottom surface of the membrane, wherein the membrane comprises at least two openings in the top surface of the membrane into each chamber to provide access to the chambers. |
| FILED | Friday, August 28, 2020 |
| APPL NO | 17/638543 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50853 (20130101) Original (OR) Class B01L 3/50855 (20130101) B01L 2200/0647 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1463 (20130101) G01N 33/505 (20130101) G01N 33/6845 (20130101) G01N 2015/1486 (20130101) G01N 2015/1488 (20130101) G01N 2015/1493 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220306584 | HSIEH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Regents of the University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jer-Tsong HSIEH (Plano, Texas); Jung-Mo AHN (Plano, Texas); Zhi-Ping LIU (Dallas, Texas) |
| ABSTRACT | The present disclosure provides a new series of 8-hydroxyquinoline derivatives/analogs that are potent KDM4 inhibitors with high activity and selectivity against KDM4 enzymes. Also disclosed are the pharmaceutical compositions comprising such 8-hydroxyquinoline-based potent KDM4 inhibitors, or a pharmaceutically acceptable salt thereof, and method of use thereof, for treating cancer and neoplastic diseases and the like. |
| FILED | Saturday, June 20, 2020 |
| APPL NO | 17/596816 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 215/26 (20130101) Original (OR) Class C07D 401/12 (20130101) C07D 401/14 (20130101) C07D 405/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220306595 | Yu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jin-quan Yu (San Diego, California); Zhe Zhuang (San Diego, California) |
| ABSTRACT | Provided herein is a method of forming a beta-lactone from a carboxylic acid having a beta-carbon with a hydrogen atom disposed thereon. The method comprises contacting a carboxylic acid of formula (1) as described herein with an effective amount of a palladium(I) catalyst, an effective amount of an N-protected aminoacid ligand, and t-butylhydroperoxide in a solvent comprising hexafluoroisopropanol (HFIP), at about 60° C. to provide a beta-lactone of formula (2) as described herein. |
| FILED | Friday, May 29, 2020 |
| APPL NO | 17/615509 |
| CURRENT CPC | Heterocyclic Compounds C07D 305/12 (20130101) Original (OR) Class C07D 405/06 (20130101) C07D 407/04 (20130101) C07D 407/06 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/6551 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220306596 | Canney et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Temple University-Of The Commonwealth System of Higher Education (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel J. Canney (Ambler, Pennsylvania); Benjamin E. Blass (Eagleville, Pennsylvania); Rong Gao (Eugene, Oregon); Magid Abou-Gharbia (Exton, Pennsylvania) |
| ABSTRACT | Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity. |
| FILED | Tuesday, November 02, 2021 |
| APPL NO | 17/517166 |
| CURRENT CPC | Heterocyclic Compounds C07D 307/28 (20130101) C07D 307/33 (20130101) Original (OR) Class C07D 307/94 (20130101) C07D 405/06 (20130101) C07D 405/12 (20130101) C07D 405/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220306621 | STARCZYNOWSKI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CHILDREN'S HOSPITAL MEDICAL CENTER (Cincinnati, Ohio); THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel T. STARCZYNOWSKI (Cincinnati, Ohio); Craig J. THOMAS (Gaithersburg, Maryland); Garrett RHYASEN (Burlington, Massachusetts); Katelyn MELGAR (Cincinnati, Ohio); Morgan MacKenzie WALKER (New Haven, Connecticut); Jian-kang JIANG (Columbia, Maryland) |
| ABSTRACT | Some embodiments of the invention include inventive compounds (e.g., compounds of Formula (I)) and compositions (e.g., pharmaceutical compositions) which can be used for treating, for example, certain diseases. Some embodiments include methods of using the inventive compound (e.g., in compositions or in pharmaceutical compositions) for administering and treating (e.g., diseases such as head and neck squamous cell carcinoma (HNSCC), cancer, blood disorders, etc.). Additional embodiments provide synergistic combinations of a BCL2 inhibitor with an IRAK inhibiting compound, and methods of using same. |
| FILED | Friday, February 28, 2020 |
| APPL NO | 16/804518 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/496 (20130101) Heterocyclic Compounds C07D 471/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220306627 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jun Wang (Tucson, Arizona); Naoya Kitamura (Tucson, Arizona) |
| ABSTRACT | This invention is in the field of medicinal chemistry and relates to a new class of small-molecules having a pyrazolopyridine (or similar) structure (e.g., Formula I) which function as inhibitors of the viral protein 2C protein activity and/or expression, and which function as therapeutics for the treatment of viral infection characterized with viral protein 2C activity and/or expression (e.g., non-polio enterovirus infection) (e.g., enterovirus D68 (EV-D68) infection, enterovirus A71 (EV-A71) infection, and coxsackievirus B3 (CVB3) infection. |
| FILED | Monday, March 28, 2022 |
| APPL NO | 17/705984 |
| CURRENT CPC | Heterocyclic Compounds C07D 471/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220306629 | Canney et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Temple University - Of The Commonwealth System of Higher Education (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel J. Canney (Philadelphia, Pennsylvania); Benjamin E. Blass (Philadelphia, Pennsylvania); Kevin M. Blattner (Exton, Pennsylvania); Douglas A. Pippin (Exton, Pennsylvania) |
| ABSTRACT | Pharmaceutical compositions of the invention comprise functionalized lactam derivatives of formula (I) having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity. A is selected from a group consisting of (group) and (group) |
| FILED | Friday, May 10, 2019 |
| APPL NO | 17/054468 |
| CURRENT CPC | Heterocyclic Compounds C07D 401/06 (20130101) C07D 471/10 (20130101) Original (OR) Class C07D 487/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220306638 | GUSTAFSON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SAN DIEGO STATE UNIVERSITY FOUNDATION (San Diego, California) |
| ASSIGNEE(S) | SAN DIEGO STATE UNIVERSITY FOUNDATION (San Diego, California) |
| INVENTOR(S) | Jeffrey L. GUSTAFSON (San Diego, California); Sean Thomas TOENJES (San Diego, California); Samuel T. ALBRIGHT (San Diego, California); Ramsey HAZIN (San Diego, California) |
| ABSTRACT | The invention provides a series of conformationally stable and selective, irreversible kinase inhibitors, and methods of using the kinase inhibitors. The effect of atropisomerism on kinase selectivity was assessed, finding improved selectivity compared to rapidly interconverting parent compounds. The compounds herein are atropisomers having increased kinase selectivity and are for use in treating conditions that benefit from selective BTK kinase inhibition. |
| FILED | Tuesday, June 23, 2020 |
| APPL NO | 17/619688 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 487/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220306663 | Klenc et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey Klenc (Atlanta, Georgia); Malgorzata Lipowska (Atlanta, Georgia); Andrew Taylor (Atlanta, Georgia) |
| ABSTRACT | This disclosure relates to compositions comprising substituted iminodiacetic acid ligands and metal tricarbonyl complexes containing the ligands and derivatives thereof. In certain embodiments, the metal tricarbonyl complexes are used as radioisotope tracers such as renal tracers. In certain embodiments, the metal complexes comprise 99mTc or Re. In certain embodiments, the ligands are substituted with a fluorine, a fluorine-18(F18) radioisotope, or other radionuclide. |
| FILED | Thursday, June 09, 2022 |
| APPL NO | 17/836994 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/4057 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 51/0402 (20130101) A61K 51/0478 (20130101) General Methods of Organic Chemistry; Apparatus Therefor C07B 59/004 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 13/00 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/60 (20130101) G01N 33/5088 (20130101) G01N 2800/347 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220306688 | Fu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Haian Fu (Decatur, Georgia); Xiulei Mo (Snellville, Georgia); Cong Tang (Decatur, Georgia) |
| ABSTRACT | This disclosure relates to the discovery that a G12V mutant of KRAS (hereinafter KRAS G12V) binds to JAK1, i.e., the existence of a KRAS G12V and JAK1 binding interaction. In certain embodiments, this disclosure relates to methods of disrupting the KRAS G12V and JAK1 interaction reversing KRAS G12V induced immune escape by cancer cells utilizing agents that prevent the binding of JAK1 to KRAS G12V. |
| FILED | Monday, June 08, 2020 |
| APPL NO | 17/617269 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 47/62 (20170801) Peptides C07K 7/02 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5011 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220306692 | Marlowe et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Timothy Marlowe (Phoenix, Arizona); Warren S. Weiner (Phoenix, Arizona) |
| ABSTRACT | This disclosure provides peptides which have an affinity for the focal adhesion targeting (FAT) domain of focal adhesion kinase (FAK). In particular, the peptides are modified and derived from the sequence of the LD2 alpha helical domain of paxillin (e.g., LD2 peptides), the LD4 domain of paxillin (e.g., LD4 peptides), and CD8 peptides. These peptides are capable of blocking an interaction between paxillin and FAK, thereby inhibiting FAK activity related to FAK-paxillin interaction. The invention further provides uses for such peptides as therapeutics for the treatment of cancer and other diseases characterized with FAK activity and/or expression (e.g., fibrosis). |
| FILED | Monday, August 31, 2020 |
| APPL NO | 17/638930 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/12 (20130101) A61K 45/06 (20130101) A61K 47/60 (20170801) A61K 49/0041 (20130101) Peptides C07K 7/64 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220306693 | PEI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dehua PEI (Columbus, Ohio); Ziqing QIAN (Columbus, Ohio) |
| ABSTRACT | Disclosed herein are peptides having activity as cell penetrating peptides. In some embodiments, the peptides can comprise a cell penetrating peptide moiety and beta-haripin turn creating moiety. In other embodiments, the peptides also comprise a cargo moiety. |
| FILED | Friday, June 03, 2022 |
| APPL NO | 17/832107 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 7/64 (20130101) Original (OR) Class C07K 14/001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220306729 | ROBBIANI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Rockefeller University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Davide ROBBIANI (Brooklyn, New York); Michel NUSSENZWEIG (New York, New York) |
| ABSTRACT | Antibodies to Zika virus (ZIKV) and dengue 1 virus (DENV1) are provided. The amino acid sequences of the antibodies may be modified. Methods for prophylaxis and/or therapy by administering the antibodies and combinations thereof are provided. Immunological detection methods using the antibodies are provided. Also provided are vaccine compositions which comprise peptides derived from ZIKV and DENV1. |
| FILED | Thursday, May 19, 2022 |
| APPL NO | 17/749044 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/42 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/1081 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220306730 | Zalzman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Maryland, Baltimore (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michal Zalzman (Baltimore, Maryland); Benjamin Portney (Baltimore, Maryland) |
| ABSTRACT | Provided herein are methods of treating cancer in a subject, comprising administering to the subject a therapeutically effective amount of an agent that inhibits the activity of ZSCAN4 in cancer cells in the subject, thereby treating the cancer. |
| FILED | Friday, May 22, 2020 |
| APPL NO | 17/613443 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/4703 (20130101) C07K 16/18 (20130101) Original (OR) Class C07K 2317/92 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2310/10 (20130101) C12N 2310/531 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220306731 | LYNES |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF CONNECTICUT (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael LYNES (Farmington, Connecticut) |
| ABSTRACT | Disclosed herein are isolated anti-metallothionein antibodies, or fragments thereof, and their use in treating intestinal inflammation, diabetes, pre-diabetes, impaired glucose tolerance, hepatitis, and/or inflammatory liver disease. |
| FILED | Wednesday, July 15, 2020 |
| APPL NO | 17/625476 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6803 (20170801) A61K 47/6843 (20170801) Peptides C07K 16/18 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/55 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220306756 | Ferrario et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wake Forest University Health Sciences (Winston-Salem, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carlos M. Ferrario (Wilmington, North Carolina); Sarfaraz Ahmad (Winston-Salem, North Carolina); Jasmina Varagic (Winston-Salem, North Carolina) |
| ABSTRACT | The present invention relates to monoclonal antibodies to angiotensin-(1-12) as well as compositions comprising the same and methods of using the same. |
| FILED | Thursday, March 24, 2022 |
| APPL NO | 17/702890 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Peptides C07K 16/2869 (20130101) Original (OR) Class C07K 2317/76 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220306763 | Pasqualini et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Renata Pasqualini (New Brunswick, New Jersey); Wadih Arap (New Brunswick, New Jersey); Fernanda Iamassaki Staquicini (New Brunswick, New Jersey); Fortunato Ferrara (Santa Fe, New Mexico); Sara D'Angelo (Santa Fe, New Mexico); Andrew R.M. Bradbury (Santa Fe, New Mexico) |
| ABSTRACT | Isolated or recombinant EphA5 or GRP78 targeting antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer. A method of rapidly identifying antibodies or antibody fragments for the treatment of cancer using a combination of in vitro and in vivo methodologies is also provided. |
| FILED | Friday, February 04, 2022 |
| APPL NO | 17/592828 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/07 (20130101) A61K 39/3955 (20130101) A61K 39/39558 (20130101) A61K 47/6803 (20170801) A61K 47/6817 (20170801) A61K 47/6843 (20170801) A61K 47/6849 (20170801) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/18 (20130101) C07K 16/28 (20130101) C07K 16/30 (20130101) Original (OR) Class C07K 16/3023 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1037 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57423 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220306768 | WANG |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CITY OF HOPE (Duarte, California) |
| ASSIGNEE(S) | CITY OF HOPE (Duarte, California) |
| INVENTOR(S) | Edward Wenge WANG (Azusa, California) |
| ABSTRACT | It was found that TRAIL-induced death signaling was largely diminished by lysosomal degradation system. Inhibition of lysosomal degradation by small molecules led to accumulation of DR5 in lysosomes and reversed TRAIL resistance in almost all cancer cells. Redirecting TRAIL-induced signaling away from lysosomal degradation may therefore induce massive cell death and overcome TRAIL resistance. Taking advantage of bioactive protein transduction domains (PTD) and signaling peptides, such as TAT peptide from HIV TAT protein, NLS (nuclear localization signal), MTS (mitochondrial targeting sequence), a series of new TRAILs fused with these peptides was constructed. It was found that TRAIL fused with bioactive peptide exerted remarkably high potency in inducing cell death in cancer cells, but not normal cells. |
| FILED | Thursday, March 24, 2022 |
| APPL NO | 17/703523 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/4747 (20130101) C07K 14/7151 (20130101) C07K 19/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220306986 | Finley et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MEMORIAL SLOAN-KETTERING CANCER CENTER (New York, New York) |
| ASSIGNEE(S) | MEMORIAL SLOAN-KETTERING CANCER CENTER (New York, New York) |
| INVENTOR(S) | Lydia W.S. Finley (New York, New York); Craig B. Thompson (New York, New York); Santosha A. Vardhana (Brooklyn, New York) |
| ABSTRACT | The present disclosure provides highly efficient, non-invasive, and reversible methods for selectively enriching pluripotent cells (e.g., human pluripotent cells and mouse pluripotent cells) in a cell population using a glutamine-deficient medium. The presently disclosed methods have the advantageous of efficiently enriching pluripotent cells in a heterogenous cell population without altering the biological properties of any individual cells. |
| FILED | Friday, October 29, 2021 |
| APPL NO | 17/514742 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0606 (20130101) Original (OR) Class C12N 2500/24 (20130101) C12N 2500/32 (20130101) C12N 2500/44 (20130101) C12N 2501/115 (20130101) C12N 2501/235 (20130101) C12N 2506/03 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220306988 | Slukvin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Igor I. Slukvin (Verona, Wisconsin); Mi Ae Park (Madison, Wisconsin); Akhilesh Kumar (Madison, Wisconsin) |
| ABSTRACT | The present invention is a method of creating a population of hemogenic endothelial cells with arterial specification. In one embodiment, the method uses ETS transgene induction at the mesodermal stage of differentiation. In another embodiment, the method activates ERK signaling at the mesodermal stage of differentiation. |
| FILED | Friday, May 27, 2022 |
| APPL NO | 17/827338 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 2035/124 (20130101) Peptides C07K 14/4702 (20130101) C07K 14/70503 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/069 (20130101) Original (OR) Class C12N 5/0636 (20130101) C12N 5/0647 (20130101) C12N 2501/42 (20130101) C12N 2501/60 (20130101) C12N 2501/727 (20130101) C12N 2506/02 (20130101) C12N 2506/28 (20130101) C12N 2506/45 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220307003 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David R. Liu (Cambridge, Massachusetts); Holly A. Rees (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure provides novel adenine base editors that retain ability to edit DNA efficiently but show greatly reduced off-target effects, such as reduced RNA editing activity, as well as lower off-target DNA editing activity and reduced indel by product formation. Also provided are base editing methods comprising contacting a nucleic acid molecule with an adenine base editor and a guide RNA that has complementarity to a target sequence. Further provided are complexes comprising a guide RNA bound to a base editor provided herein; and kits and pharmaceutical compositions for the administration of adenine base editor variants to a host cell. |
| FILED | Thursday, April 16, 2020 |
| APPL NO | 17/603917 |
| CURRENT CPC | Peptides C07K 2319/09 (20130101) C07K 2319/80 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/78 (20130101) Original (OR) Class C12N 15/102 (20130101) C12N 2310/20 (20170501) C12N 2320/31 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220307013 | Mali et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Prashant Mali (La Jolla, California); Kyle M. Ford (La Jolla, California); Nathan Palmer (La Jolla, California); Rebecca Panwala (La Jolla, California) |
| ABSTRACT | The disclosure provides for screening methodologies using gene fragment overexpression that provide for the identification of peptide sequences which can modulate the functional regions of proteins of interests, and uses thereof. The disclosure further relates to peptide, polypeptide and polynucleotide identified by the methods of the disclosure, compositions containing such peptide, polypeptide and polynucleotides and uses thereof. |
| FILED | Friday, August 28, 2020 |
| APPL NO | 17/638428 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/71 (20130101) C07K 14/82 (20130101) C07K 14/4703 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1079 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220307015 | Gersbach et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles A. Gersbach (Chapel Hill, North Carolina); Joshua B. Black (Durham, North Carolina); Jennifer Kwon (Durham, North Carolina); Shaunak Adkar (Durham, North Carolina) |
| ABSTRACT | Disclosed herein are compositions, methods, and systems for selecting a polynucleotide for activity as a neuronal-specific transcription factor. The system may include a polynucleotide encoding a reporter protein and a pan-neuronal marker, a Gas protein, and a library of guide RNAs (gRNAs) targeting putative transcription factors. Further provided are methods of screening for a neuronal-specific transcription factor. |
| FILED | Wednesday, August 19, 2020 |
| APPL NO | 17/636750 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/4705 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0619 (20130101) C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/1086 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2501/60 (20130101) C12N 2506/45 (20130101) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220307025 | RANDO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Oliver RANDO (Natick, Massachusetts); Upasna SHARMA (Shrewsbury, Massachusetts); Colin CONINE (Brighton, Massachusetts) |
| ABSTRACT | Methods and compositions directed to altering a population of sRNAs in a sperm using vesicles isolated from an epididymosome are provided. Methods and compositions directed to altering a population of sRNAs in an oocyte using vesicles isolated from an epididymosome are also provided. Methods for altering an sRNA population in a sperm or an oocyte can be used to prevent, or reduce the severity of, a disease, disorder, or condition that would otherwise be inherited by progeny. For example, certain epigenetic inherited conditions due to paternal effects, such as certain metabolic and stress disorders and conditions, can be ameliorated in progeny using sperm or oocytes having an altered sRNA population. |
| FILED | Thursday, March 03, 2022 |
| APPL NO | 17/686352 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/43 (20130101) A61B 17/435 (20130101) Veterinary Instruments, Implements, Tools, or Methods A61D 19/02 (20130101) A61D 19/04 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/0034 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/061 (20130101) C12N 5/0604 (20130101) C12N 15/111 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/141 (20130101) C12N 2320/30 (20130101) C12N 2501/65 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220307028 | BRAR |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | JAAN BIOTHERAPEUTICS LLC (SAN DIEGO, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | BHAWANJIT KAUR BRAR (San Diego, California) |
| ABSTRACT | There are provided, in some embodiments, therapeutic compositions and methods for preventing, inhibiting, reducing, or treating cardiac ischemic reperfusion injury. The therapeutic composition can comprise a plurality of microRNA (miR) antagonists. In some embodiments, the method comprises administering a therapeutic composition to a subject before, during, and/or after a cardiac ischemic event. The method can comprise reperfusion of ischemic cardiac tissue. |
| FILED | Tuesday, October 20, 2020 |
| APPL NO | 17/770031 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/00 (20180101) A61P 13/12 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/113 (20130101) C12N 2310/315 (20130101) C12N 2310/3231 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220307030 | RONAI |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sanford Burnham Prebys Medical Discovery Institute (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ze'ev A. RONAI (Escondido, California) |
| ABSTRACT | Described herein are methods and compositions for diagnosing, treating, or ameliorating symptoms of cancer, including pancreatic cancer and melanoma, with ASNS synthetic lethal partners. |
| FILED | Friday, May 29, 2020 |
| APPL NO | 17/616126 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/437 (20130101) A61K 31/4184 (20130101) A61K 38/50 (20130101) A61K 38/465 (20130101) A61K 39/3955 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/18 (20180101) A61P 17/00 (20180101) A61P 35/00 (20180101) Peptides C07K 16/40 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) C12N 15/1137 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/20 (20170501) C12N 2320/31 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220307034 | Zhao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Cleveland Clinic Foundation (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jianjun Zhao (Cleveland, Ohio); Jianhong Lin (Cleveland, Ohio) |
| ABSTRACT | Provided herein are compositions, systems, articles of manufacture, and methods of treating a subject with: i) an APE2 inhibitor, and ii) a drug agent that causes increased expression of APE2 in said subject. In certain embodiments, the drug agent is Cisplatin or similar drug. |
| FILED | Wednesday, March 16, 2022 |
| APPL NO | 17/696510 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/14 (20130101) A61K 31/085 (20130101) A61K 31/282 (20130101) A61K 31/381 (20130101) A61K 31/427 (20130101) A61K 31/454 (20130101) A61K 31/506 (20130101) A61K 31/519 (20130101) A61K 31/549 (20130101) A61K 31/4985 (20130101) A61K 31/7056 (20130101) A61K 33/243 (20190101) A61K 39/3955 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 13/12 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) Original (OR) Class C12N 2310/11 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220307054 | FRÜH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Oregon Health and Science University (Portland, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Klaus J. FRÜH (Portland, Oregon); Scott G. HANSEN (Portland, Oregon); Daniel MALOULI (Hillsboro, Oregon); Louis J. PICKER (Portland, Oregon) |
| ABSTRACT | The disclosure relates to methods of modulating T cell responses by UL18 of human cytomegalovirus. The disclosure also relates to methods of generating MHC-Ia, MHC-II, and/or MHC-E restricted CD8+ T cells. |
| FILED | Wednesday, August 19, 2020 |
| APPL NO | 17/636506 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) A61P 37/02 (20180101) Peptides C07K 14/005 (20130101) C07K 16/2833 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0638 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 2710/16143 (20130101) C12N 2740/15034 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220307066 | Olanrewaju et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington); The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington); The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Ayokunle Olanrewaju (Seattle, Washington); Paul Drain (Seattle, Washington); Jonathan Posner (Seattle, Washington); Derin Sevenler (Boston, Massachusetts); Benjamin Sullivan (Seattle, Washington); Andrew Bender (Seattle, Washington); Jane Zhang (Seattle, Washington); Rebecca Sandlin (Boston, Massachusetts) |
| ABSTRACT | The disclosure addresses methods, compositions, and kits used to detect or quantify polymerase inhibitors in biological samples. The polymerase inhibitors can be therapeutic agents, or metabolites thereof, that have been administered to a subject as part of, for example, antiretroviral therapy (ART) or pre-exposure prophylaxis (PrEP) to address potential infections by, e.g., retroviruses such as HIV and other viruses reliant on reverse transcription. These methods, compositions, and kits can be applied to monitor a subject's compliance with the indicated therapies and can inform potential adjustments to the therapies. |
| FILED | Friday, June 12, 2020 |
| APPL NO | 17/618323 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/48 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/64 (20130101) G01N 33/53 (20130101) G01N 33/58 (20130101) G01N 2333/9126 (20130101) G01N 2333/91255 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220307079 | Hodko et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Nexogen, Inc. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dalibor Hodko (Poway, California); Nives Hodko (Poway, California); Zuxu Yao (San Diego, California) |
| ABSTRACT | The invention relates to a microfluidic system based on active control of flow resistance and balancing pressures in microfluidic channels and an improved method for enhancing reactions with magnetic beads used in disposable microfluidic devices and cartridges for use in, but not limited to, in-vitro diagnostics. The microfluidic system and device of the invention does not utilize mechanical moving parts to control the fluid flow and has no external fluidic connection to the instrument or fluidics controller. The microfluidic system and device combines magnetic control over the movement of magnetic detection beads with electric field and convective enhancement of the movement of analytes and/or or reagentss surrounding the magnetic detection beads, thereby enabling movement of magnetic beads and analytes in the same direction or in different directions. The present invention thereby provides significantly enhanced interactions between analytes and/or reagents with the magnetic beads, which yields higher sensitivity for detection. |
| FILED | Monday, November 29, 2021 |
| APPL NO | 17/537443 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) B01L 2200/16 (20130101) B01L 2200/0647 (20130101) B01L 2200/0684 (20130101) B01L 2300/0645 (20130101) B01L 2400/043 (20130101) B01L 2400/084 (20130101) B01L 2400/0415 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6851 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220307089 | ABATE-SHEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York); Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cory ABATE-SHEN (New York, New York); Juan ARRIAGA (New York, New York); Antonina MITROFANOVA (Newark, New Jersey) |
| ABSTRACT | The present technology is directed to methods for diagnosing metastasis, or assessing risk of metastasis, in a subject having cancer. The present technology is also directed to methods for treating a subject having metastatic cancer or an increased risk of cancer metastasis; through the development of gene signatures with prognostic value for determining metastasis in human patients undergoing AR therapy. When compared to controls, the expression level of the genes is highly correlative with the presence of metastasis, as well as the risk of future cancer metastasis. The present technology is also directed to biomarkers that can identify and categorize the needs of different patients for less or more aggressive therapy to prevent or treat metastatic disease outcome. |
| FILED | Wednesday, March 16, 2022 |
| APPL NO | 17/696550 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220307091 | Jarrard et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Frazier Jarrard (Madison, Wisconsin); Bing Yang (Madison, Wisconsin) |
| ABSTRACT | A method of detecting the presence of a prostate cancer field defect in a human subject comprising the step of (a) obtaining genomic DNA from the human subject and (b) quantitating methylation in at least one target region selected from the group consisting of CAV1, EVX1, MCF2L, FGF1, NCR2 and WNT2 and EXT1 and SPAG4 target, wherein significant methylation changes indicate the presence of prostate cancer or a prostate cancer field defect, wherein the change is relative to tissue from a second human subject who does not have prostate cancer. |
| FILED | Friday, June 10, 2022 |
| APPL NO | 17/837731 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/154 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220308044 | Park et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF UTAH RESEARCH FOUNDATION (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | SungJin Park (Salt Lake City, Utah); Ana Santos (Salt Lake City, Utah); Kevin Huang (Salt Lake City, Utah) |
| ABSTRACT | Disclosed herein are neuronal cell activity reporter systems including a Secreted Neuronal Activity Reporter (SNAR) construct and a control construct. The SNAR construct includes four tandem repeats of a core domain of the Synaptic Activity Response Element (SARE) of Arc/Arg3.1, a polynucleotide comprising the Arc minimal promoter, and a polynucleotide encoding a first secreted reporter protein. The control construct includes a constitutive promoter and a polynucleotide encoding a second secreted reporter protein. Further provided are methods of monitoring neuronal activity in a cell. The methods may include administering to a cell the neuronal cell activity reporter system, contacting with a substrate, and measuring a signal. |
| FILED | Friday, June 19, 2020 |
| APPL NO | 17/616111 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0069 (20130101) C12N 15/86 (20130101) C12N 2740/15043 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5058 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220308052 | Fu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland); THE REGENTS OF UNIVERSITY OF COLORADO, A BODY CORPORATE (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dax Fu (Short Hills, New Jersey); Chengfeng Merriman (Essex, Maryland); Liping Yu (Centennial, Colorado); Yong Gu (Centennial, Colorado) |
| ABSTRACT | The present invention relates to the field of autoimmunity. More specifically, the present invention provides compositions and methods useful for detecting autoantibodies. In one embodiment, a method for detecting autoantibodies to ZnT8 comprises the steps of (a) contacting in a first mixture a biological sample obtained from a patient with a ZnT8-antibody complex, wherein the ZnT8-antibody complex comprises ZnT8 and at least one detectably labeled anti-ZnT8 antibody or antigen-binding fragment thereof that specifically binds to the cytoplasmic domain of ZnT8; (b) contacting in a second mixture the first mixture of step (a) with an immunoglobulin G (IgG) labeled with a tag molecule; (c) contacting the second mixture of step (b) with a solid substrate coated with a capture molecule that specifically binds the tag molecule; and (d) detecting a signal emitted from the detectably labeled anti-ZnT8 antibody or antigen-binding fragment thereof. |
| FILED | Monday, June 08, 2020 |
| APPL NO | 17/616864 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/49 (20130101) G01N 33/533 (20130101) G01N 33/536 (20130101) G01N 33/564 (20130101) Original (OR) Class G01N 2800/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220308061 | Witte et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Twelfth Floor, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Owen N. Witte (Sherman Oaks, California); Pavlo A. Nesterenko (Los Angeles, California); Jami McLaughlin Witte (Sherman Oaks, California) |
| ABSTRACT | The disclosure provides methods and materials useful for obtaining novel TCR gene sequences that are useful in tumor-specific T cell receptor (TCR) gene transfer. Embodiments of the invention also include methods of crosslinking and permeabilizing mammalian cells that can, for example, be used in methods for obtaining novel TCR gene sequences. The disclosure further provides methods and materials useful for obtaining novel TCR gene sequences. Tumor-specific T cell receptor gene transfer enables specific and potent immune targeting of tumor and viral antigens, and for this reason is technology of significant interest to medical personnel. |
| FILED | Wednesday, September 02, 2020 |
| APPL NO | 17/638092 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6804 (20130101) C12Q 1/6806 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56972 (20130101) G01N 33/57484 (20130101) Original (OR) Class G01N 2015/149 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220308062 | Taverna et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Josephine Taverna (San Antonio, Texas); Chia-Nung Hung (San Antonio, Texas); Tim Huang (San Antonio, Texas); Nameer Kirma (San Antonio, Texas); Daniel Dearmond (San Antonio, Texas); Chiou-Min Wang (San Antonio, Texas); Meizhen Chen (San Antonio, Texas); Pawel A. Osmulski (San Antonio, Texas); Maria E. Gaczynska (San Antonio, Texas) |
| ABSTRACT | Described herein are compositions and methods for predicting drug responsiveness in cellular samples from cancer subjects. Described herein are compositions and methods that can help determine treatment options and select subjects for clinical trials. |
| FILED | Thursday, May 07, 2020 |
| APPL NO | 17/608891 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57423 (20130101) G01N 33/57492 (20130101) Original (OR) Class G01N 2333/705 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220308064 | Belcher et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott M. Belcher (Raleigh, North Carolina); Thomas W. Jackson (Raleigh, North Carolina) |
| ABSTRACT | Disclosed herein are compositions and methods for characterizing protein binding to per-and polyfluoroalkyl substances (PFAS). |
| FILED | Friday, March 25, 2022 |
| APPL NO | 17/704825 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/68 (20130101) Original (OR) Class G01N 33/582 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220308065 | SMITH |
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| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | Vanderbilt University (Nashville, Tennessee) |
| INVENTOR(S) | Scott A. SMITH (White Bluff, Tennessee) |
| ABSTRACT | The present disclosure is directed to human monoclonal IgE antibodies, and IgG antibodies engineered therefrom. Such engineered antibodies can be used to blunt pathologic IgE responses in subjects, such as in the treatment or prevention of allergies. |
| FILED | Thursday, May 26, 2022 |
| APPL NO | 17/826108 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/35 (20130101) A61K 45/06 (20130101) Peptides C07K 16/16 (20130101) C07K 16/18 (20130101) C07K 2317/21 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/686 (20130101) Original (OR) Class G01N 33/5308 (20130101) G01N 2333/43526 (20130101) G01N 2333/43582 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220308242 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ge Wang (Loudonville, New York); Mengzhou Li (Troy, New York); David S. Rundle (Butler, Pennsylvania) |
| ASSIGNEE(S) | Rensselaer Polytechnic Institute (Troy, New York) |
| INVENTOR(S) | Ge Wang (Loudonville, New York); Mengzhou Li (Troy, New York); David S. Rundle (Butler, Pennsylvania) |
| ABSTRACT | A method for x-ray photon-counting data correction. The method includes generating, by a training data generation module, training input spectral projection data based, at least in part, on a reference spectral projection data. The training input spectral projection data includes at least one of a pulse pileup distortion, a charge splitting distortion, and/or noise. The method further includes training, by a training module, a data correction artificial neural network (ANN) based, at least in part, on training data. The data correction ANN includes a pulse pileup correction ANN, and a charge splitting correction ANN. The training data includes the training input spectral projection data and the reference spectral projection data. |
| FILED | Friday, March 25, 2022 |
| APPL NO | 17/704520 |
| CURRENT CPC | Measurement of Nuclear or X-radiation G01T 1/17 (20130101) Original (OR) Class G01T 1/36 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 3/0454 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220308327 | Cheng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Boston University (Boston, Massachusetts) |
| ASSIGNEE(S) | Trustees of Boston University (Boston, Massachusetts) |
| INVENTOR(S) | Ji-Xin Cheng (Newton, Massachusetts); Celalettin Yurdakul (Brighton, Massachusetts); Haonan Zong (Allston, Massachusetts); M. Salim Unlü (Newton, Massachusetts) |
| ABSTRACT | Microscopic analysis of a sample includes a system using dark-field illumination. A mid-IR optical source generates a mid-infrared beam, which is directed onto the sample to induce a temperature change by absorption of the mid-infrared beam. A visible light source generates a light illuminating the sample on a substrate and creating a scattered field and a reflected field along a collection path of the system. A pupil mask is positioned along the collection path to block the reflected field while allowing the scattered field to pass therethrough. A camera is positioned at an end of the collection path to collect the scattered field and generate a dark-field image of the sample. |
| FILED | Friday, March 25, 2022 |
| APPL NO | 17/704896 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 21/16 (20130101) Original (OR) Class G02B 21/025 (20130101) G02B 21/361 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220309092 | Daugharthy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Evan R. Daugharthy (Cambridge, Massachusetts); Vivek Dasari (Cambridge, Massachusetts); George M. Church (Brookline, Massachusetts) |
| ABSTRACT | Methods, systems, and computer-readable media for processing spatially related sequence data received from a sequencing device are presented. In one or more embodiments, a computing platform may receive, from a sequencing device, image data associated with a sample. The computing platform may identify, based on the image data received from the sequencing device, a first sequence located at first spatial coordinates. Subsequently, the computing platform may store, in a spatially searchable database, a first data element comprising the first spatial coordinates and a first identifier corresponding to the first sequence to spatially relate the first sequence to other sequences present in the sample. In some instances, the image data received from the sequencing device may include spatial information, temporal information, and color information associated with the sample, and the computing platform may present, on a display device, information identifying a presence of the first sequence at the first spatial coordinates. |
| FILED | Friday, May 27, 2022 |
| APPL NO | 17/826762 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/532 (20190101) Original (OR) Class G06F 16/538 (20190101) Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/70 (20170101) G06T 7/90 (20170101) G06T 7/187 (20170101) G06T 7/194 (20170101) G06T 2200/04 (20130101) G06T 2207/10056 (20130101) G06T 2207/10148 (20130101) G06T 2207/30024 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 25/00 (20190201) G16B 30/00 (20190201) G16B 45/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220309653 | Hassanpour et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Dartmouth College (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Saeed Hassanpour (Hanover, New Hampshire); Naofumi Tomita (Hanover, New Hampshire) |
| ABSTRACT | This invention provides a system and method for analyzing and classifying imaged from whole slides of tissue. A source of image data transmits images of the tissue on the whole slides to a GPU. The GPU performs a feature extraction process that identifies and segments regions of interests in each of the images, and an attention network that, based upon training from an expert, identifies trained characteristics can comprise cancerous and/or pre-cancerous conditions/e.g. those associated with a gastrointestinal tract, such ad Barret's Esophagus. The feature extraction process can include a convolutional neural network (CNN). The attention network can be adapted performs attention/based weighting of features relative to the trained characteristics, and/or the attention network can include 3D convolutional filters. The image data is acquired using an image sensor having approximately 100 Megapixel resolution. |
| FILED | Wednesday, April 08, 2020 |
| APPL NO | 17/608016 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 2207/10056 (20130101) G06T 2207/30004 (20130101) Image or Video Recognition or Understanding G06V 10/82 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220309705 | Kodandaramaiah et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Suhasa B. Kodandaramaiah (St Paul, Minnesota); Daryl M. Gohl (Minneapolis, Minnesota); Andrew Alegria (Minneapolis, Minnesota); Amey S. Joshi (Minneapolis, Minnesota); Benjamin Auch (Saint Paul, Minnesota) |
| ABSTRACT | Techniques are described for automated microinjection of substances, such as genetic material, into microscopic objects, such as embryos. An example system includes a pressure controller, a stereoscopic imaging apparatus, a first camera, a second camera, and a computing system. The computing system is configured to apply one or more computer vision algorithms that determine, based on image data generated by the stereoscopic imaging apparatus, first camera, and second camera, a location of a tip of a micropipette and a location of a particular microscopic object in three-dimensional space. The computing system is further configured to control the pressure controller to cause the micropipette to eject the substance from the tip of the micropipette and into the particular microscopic object. |
| FILED | Wednesday, March 23, 2022 |
| APPL NO | 17/656130 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 3/40 (20130101) G06T 7/74 (20170101) Original (OR) Class G06T 2207/10012 (20130101) G06T 2207/20084 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220309811 | Haghighi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fatemeh Haghighi (Tempe, Arizona); Mohammad Reza Hosseinzadeh Taher (Tempe, Arizona); Zongwei Zhou (Tempe, Arizona); Jianming Liang (Scottsdale, Arizona) |
| ABSTRACT | Described herein are means for the generation of Transferable Visual Word (TransVW) models through self-supervised learning in the absence of manual labeling, in which the trained TransVW models are then utilized for the processing of medical imaging. For instance, an exemplary system is specially configured to perform self-supervised learning for an AI model in the absence of manually labeled input, by performing the following operations: receiving medical images as input; performing a self-discovery operation of anatomical patterns by building a set of the anatomical patterns from the medical images received at the system, performing a self-classification operation of the anatomical patterns; performing a self-restoration operation of the anatomical patterns within cropped and transformed 2D patches or 3D cubes derived from the medical images received at the system by recovering original anatomical patterns to learn different sets of visual representation; and providing a semantics-enriched pre-trained AI model having a trained encoder-decoder structure with skip connections in between based on the performance of the self-discovery operation, the self-classification operation, and the self-restoration operation. Other related embodiments are disclosed. |
| FILED | Saturday, February 19, 2022 |
| APPL NO | 17/676134 |
| CURRENT CPC | Image or Video Recognition or Understanding G06V 10/26 (20220101) G06V 10/82 (20220101) G06V 10/761 (20220101) G06V 10/764 (20220101) G06V 10/774 (20220101) G06V 20/70 (20220101) Original (OR) Class G06V 2201/03 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220310243 | BRESSNER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Jarred A. BRESSNER (Baltimore, Maryland); Mikhail OSANOV (Baltimore, Maryland); James K. GUEST (Lutherville Timonium, Maryland) |
| ABSTRACT | An implant customization platform may receive image data associated with a bone of a patient. The implant customization platform may convert the image data to a structural representation of the bone. The implant customization platform may identify, based on the structural representation, a placement for an orthopaedic implant relative to the bone. The implant customization platform may determine a performance characteristic for a combination of the bone and the orthopaedic implant. The implant customization platform may determine, using an implant customization model, a data representation of the orthopaedic implant based on the structural representation, the placement, and the performance characteristic. The implant customization platform may perform an action associated with the data representation to permit the orthopaedic implant to be formed. |
| FILED | Wednesday, July 22, 2020 |
| APPL NO | 17/597221 |
| CURRENT CPC | Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) G16H 30/20 (20180101) G16H 40/63 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220310266 | Baronov et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Etiometry, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Etiometry, Inc. (Boston, Massachusetts); Etiometry, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Dimitar V. Baronov (Weston, Massachusetts); Evan J. Butler (New Haven, Connecticut); Jesse M. Lock (Winchester, Massachusetts); Michael F. McManus (Pembroke, Massachusetts) |
| ABSTRACT | A risk-based patient monitoring system for critical care patients combines data from multiple sources to assess the current and the future risks to the patient, thereby enabling providers to review a current patient risk profile and to continuously track a clinical trajectory. A physiology observer module in the system utilizes multiple measurements to estimate Probability Density Functions (PDF) of a number of Internal State Variables (ISVs) that describe a components of the physiology relevant to the patient treatment and condition. A clinical trajectory interpreter module in the system utilizes the estimated PDFs of ISVs to identify under which probable patient states the patient can be currently categorized and assign a probability value that the patient will be in each of the identified states. The combination of patient states and their probabilities is defined as the clinical risk to the patient. |
| FILED | Tuesday, May 17, 2022 |
| APPL NO | 17/745983 |
| CURRENT CPC | Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) G16H 50/30 (20180101) Original (OR) Class G16H 50/50 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220310378 | EBERLIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| INVENTOR(S) | Livia Schiavinato EBERLIN (Austin, Texas); Thomas MILNER (Austin, Texas); Jialing ZHANG (Austin, Texas); John LIN (Austin, Texas); John RECTOR (Austin, Texas); Nitesh KATTA (Austin, Texas); Aydin ZAHEDIVASH (Austin, Texas) |
| ABSTRACT | Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for the collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis. |
| FILED | Thursday, December 30, 2021 |
| APPL NO | 17/566192 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 10/0045 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/0293 (20130101) B01L 3/502 (20130101) B01L 2200/0605 (20130101) B01L 2400/0655 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/02 (20130101) G01N 30/72 (20130101) G01N 33/487 (20130101) G01N 33/574 (20130101) G01N 33/6848 (20130101) G01N 2560/00 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/04 (20130101) H01J 49/0031 (20130101) H01J 49/0431 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20220305103 | SHEN |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Methodist Hospital (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Haifa SHEN (Bellaire, Texas) |
| ABSTRACT | Disclosed are biocompatible core/shell compositions suitable for the delivery of populations of mRNA molecules to mammalian cells. The disclosed core-shell structured multicomponent compositions are optimized for the delivery of mRNAs encoding one or more cancer- or tumor-specific antigens to a population of antigen presenting cells, including, for example, human dendritic cells, macrophages and B cells. Also disclosed are methods for use of these compositions as therapeutic cancer vaccines. |
| FILED | Tuesday, May 24, 2022 |
| APPL NO | 17/751812 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/127 (20130101) A61K 9/1271 (20130101) A61K 39/0011 (20130101) Original (OR) Class A61K 39/39 (20130101) A61K 39/001104 (20180801) A61K 39/001106 (20180801) A61K 39/001156 (20180801) A61K 45/06 (20130101) A61K 47/645 (20170801) A61K 47/6925 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220305483 | Kelley et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Jude Kelley (Bolton, Massachusetts); Eric Morgan (Bolton, Massachusetts); Roderick Russell Kunz (Acton, Massachusetts) |
| ABSTRACT | Methods, systems, and compositions related to the recycling and/or recovery of activating materials from activated aluminum are disclosed. In one embodiment, an aqueous solution's composition may be controlled to maintain aluminum ions dissolved in solution during reaction of an activated aluminum. In another embodiment, aluminum hydroxide containing the activating materials may be dissolved into an aqueous solution to isolate the activating materials. |
| FILED | Friday, March 25, 2022 |
| APPL NO | 17/705175 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/08 (20130101) B01J 23/94 (20130101) B01J 38/64 (20130101) B01J 38/68 (20130101) Original (OR) Class B01J 2523/31 (20130101) B01J 2523/32 (20130101) B01J 2523/33 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220305686 | Burgoa |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Naval Information Warfare Center Pacific (San Diego, California) |
| ASSIGNEE(S) | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (San Diego, California) |
| INVENTOR(S) | Robert David Burgoa (El Cajon, California) |
| ABSTRACT | An underwater line cutting tool includes a cutter. The cutter includes a blade holder and a rotating manipulator arm. The blade holder includes two stationary arms in a V-shaped configuration including at least one blade attached to one of two stationary arms. The blade holder is attached to the rotating manipulator arm of a rotating manipulator that is attached to an underwater remotely operated vehicle. |
| FILED | Wednesday, March 24, 2021 |
| APPL NO | 17/210996 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 15/0019 (20130101) Cutting; Details Common to Machines for Perforating, Punching, Cutting-out, Stamping-out or Severing B26D 1/0006 (20130101) B26D 1/26 (20130101) Original (OR) Class B26D 7/2614 (20130101) B26D 2001/002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220306324 | Murphey et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Opterus Research and Development, Inc. (Fort Collins, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas W. Murphey (Fort Collins, Colorado); Levi Nicholson (Fort Collins, Colorado) |
| ABSTRACT | A self-deployable array of panels includes a plurality of panels, each panel having a first compressed panel thickness state and a second expanded panel thickness state, and including a spring bias element biased to the second expanded panel thickness state. A plurality of locking hinges hingedly couple each of the panels to an adjoining panel. Each locking hinge is biased to an open position. A release of stored potential energy of both of the spring bias element biased to the second expanded panel thickness state, and the locking hinges biased to the open position causes the self-deployable array of panels to self-deploy from a folded stowed state. A single part offset locking hinge is also described. |
| FILED | Tuesday, March 22, 2022 |
| APPL NO | 17/701277 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/443 (20130101) Original (OR) Class Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 30/10 (20141201) H02S 30/20 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220306475 | Arnold et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Scott Arnold (Middleton, Wisconsin); Robert Michael Jacobberger (Evanston, Illinois); Padma Gopalan (Madison, Wisconsin); Jonathan H. Dwyer (Madison, Wisconsin) |
| ABSTRACT | Methods of transferring nanostructures from a first substrate to another substrate using a copolymer polymerized from one or more non-crosslinking monomers and one or more comonomers bearing crosslinkable groups as a transfer medium are provided. Relative to a poly(methyl methacrylate) homopolymer, the crosslinkable copolymers bond more strongly to the first substrate and, as a result, are able to transfer even very narrow nanostructures between substrates with high transfer yields. |
| FILED | Tuesday, March 23, 2021 |
| APPL NO | 17/209944 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/194 (20170801) Original (OR) Class C01B 2204/06 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2004/03 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 133/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220306544 | Dickerson et al. |
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| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew B. Dickerson (Beavercreek, Ohio); John J. Bowen (Dayton, Ohio) |
| ABSTRACT | The present invention relates to gels and processes for making bundles of aligned ceramic nanofibers, ceramic nanostructures made by such processes, and methods of using such ceramic nanostructures. Such process is templated via block copolymer self-assembly but does not require any post processing thermal and/or solvent annealing steps. As a result, such process is significantly more efficient and scalable than other processes that are templated via block copolymer self-assembly. The resulting fibers are aligned according to the direction of deposition, making steps where individual fibers are bundled unnecessary. |
| FILED | Wednesday, June 23, 2021 |
| APPL NO | 17/355841 |
| CURRENT CPC | Shaping Clay or Other Ceramic Compositions; Shaping Slag; Shaping Mixtures Containing Cementitious Material, e.g Plaster B28B 1/001 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 80/00 (20141201) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/64 (20130101) C04B 35/571 (20130101) Original (OR) Class C04B 35/624 (20130101) C04B 35/62281 (20130101) C04B 35/63424 (20130101) C04B 2235/95 (20130101) C04B 2235/483 (20130101) C04B 2235/5244 (20130101) C04B 2235/6021 (20130101) C04B 2235/6026 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 8/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220306887 | Timler et al. |
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| FUNDED BY |
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| APPLICANT(S) | Science Applications International Corporation (Reston, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Timler (River Ridge, Louisiana); Xingcun C. Tong (Reston, Virginia) |
| ABSTRACT | Self-sintering conductive inks can be printed and self-sintered with a simple and low-cost process mechanized by exothermic alkali metal and water reaction, with enhanced electrical and thermal performance by liquid metal fusion. Such self-sintering conductive inks may include a gallium-alkali metal component and a water absorbing gel component. After patterning, the self-sintering inks, on reaching a designed trigger temperature (including room temperature), may metallize through a two-step process. Initially the gallium-alkali metal component activates and reacts with water released from the water absorbing gel component. Then the exothermic reaction between the water and the alkali element creates an intense and highly localized heating effect, which liquefies all metallic components in the ink and, on cooling, creates a solid metal trace or interconnect. Post cooling, the metal trace or interconnect cannot be reflowed without a significant temperature increase or other energetic input. |
| FILED | Wednesday, March 24, 2021 |
| APPL NO | 17/211248 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/033 (20130101) C09D 11/38 (20130101) C09D 11/52 (20130101) Original (OR) Class C09D 11/102 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/097 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220306922 | Omenetto et al. |
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| FUNDED BY |
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| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts); University of Bari Aldo Moro (Bari, Italy) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fiorenzo G. Omenetto (Lexington, Massachusetts); Gianluca M. Farinola (Bari, Italy); Marco Lo Presti (Bari, Italy) |
| ABSTRACT | An adhesive composition and methods of making and using the same are disclosed. The composition includes a polymeric component and a metal cation or an oxidant. The polymeric component includes a silk fibroin protein and a catecholamine. The metal cation and/or the oxidant is present in an amount sufficient to initiate complexing and/or cross-linking of the adhesive composition. |
| FILED | Friday, June 19, 2020 |
| APPL NO | 17/596896 |
| CURRENT CPC | Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 189/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220306936 | Rand et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Barry P. Rand (Princeton, New Jersey); Zhengguo Xiao (Plainsboro, New Jersey) |
| ABSTRACT | In one aspect, organic-inorganic nanoparticle compositions are described herein comprising engineered surfaces which, in some embodiments, reduce non-radiative recombination mechanisms, thereby providing optoelectronic devices with enhanced efficiencies. In some embodiments, a nanoparticle composition comprises a layer of organic-inorganic perovskite nanocrystals, the organic-inorganic perovskite nanocrystals comprising surfaces associated with growth passivation ligands and trap passivation ligands, wherein the growth passivation ligands are larger than the trap passivation ligands and are of size unable to incorporate into octahedral corner sites of the perovskite crystal structure. |
| FILED | Friday, October 11, 2019 |
| APPL NO | 17/413271 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 20/00 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) Original (OR) Class C09K 2211/10 (20130101) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 9/2009 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0077 (20130101) H01L 51/4213 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220306943 | Seibert et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Government of the United States, as represented by the Secretary of the Army (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Seibert (Bel Air, Maryland); Richard Scenna (Baltimore, Maryland); Terry DuBois (Forest Hill, Maryland) |
| ABSTRACT | Various embodiments that pertain to fuel processing are described. A fuel processor can produce an endothermic reaction that cools a substance and produces a processed fuel from a raw fuel. A generator can employ the processed fuel to produce an electricity. The generator can supply the electricity to a load that uses the electricity to function. The load can become hot due to its functioning and can benefit from being cooled. The substance cooled by the fuel processor can cool load and in the process the substance can rise in temperature. This warmer substance can be transferred to the fuel processor to be cooled again and this cycle can continue. Further, the fuel processor can use the warmer substance to achieve the endothermic reaction. |
| FILED | Monday, March 29, 2021 |
| APPL NO | 17/215498 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 3/34 (20130101) C01B 2203/06 (20130101) C01B 2203/0233 (20130101) C01B 2203/0883 (20130101) Cracking Hydrocarbon Oils; Production of Liquid Hydrocarbon Mixtures, e.g by Destructive Hydrogenation, Oligomerisation, Polymerisation; Recovery of Hydrocarbon Oils From Oil-shale, Oil-sand, or Gases; Refining Mixtures Mainly Consisting of Hydrocarbons; Reforming of Naphtha; Mineral Waxes C10G 9/40 (20130101) Original (OR) Class C10G 2300/4081 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 1/05 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/764 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220307004 | Medintz et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Igor L. Medintz (Springfield, Virginia); Joyce C. Breger (Washington, District of Columbia); Gregory A. Ellis (Washington, District of Columbia); Kirk Malone (Manchester, United Kingdom); Nigel Scrutton (Manchester, United Kingdom) |
| ABSTRACT | Multi-enzyme systems attached to nanoparticles are effective to efficiently and controllably incorporate stable isotopes (such as deuterium) during the synthesis of small molecules. In one example, deuterium is incorporated into (+)-dihydrocarvide using a cascade involving the enzymes (a) pentaerythritol tetranitrate reductase (PETNR) and (b) flavin-dependent cyclohexanone monooxygenase triple variant F249A/F280A/F435A (CHMO3M). |
| FILED | Monday, March 28, 2022 |
| APPL NO | 17/705781 |
| CURRENT CPC | General Methods of Organic Chemistry; Apparatus Therefor C07B 59/001 (20130101) C07B 59/002 (20130101) C07B 2200/05 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0006 (20130101) C12N 11/18 (20130101) Original (OR) Class Enzymes C12Y 101/01002 (20130101) C12Y 101/01162 (20130101) C12Y 114/13022 (20130101) C12Y 403/01024 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220307040 | THESS et al. |
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| FUNDED BY |
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| APPLICANT(S) | CureVac AG (Tubingen, Germany) |
| ASSIGNEE(S) | CureVac AG (Tübingen, Germany) |
| INVENTOR(S) | Andreas THESS (Kusterdingen, Germany); Thomas SCHLAKE (Gundelfingen, Germany); Stefanie GRUND (Stuttgart, Germany) |
| ABSTRACT | The invention relates to an artificial nucleic acid molecule comprising an open reading frame and a 3′-UTR comprising at least one poly(A) sequence or a polyadenylation signal. The invention further relates to a vector comprising the artificial nucleic acid molecule comprising an open reading frame and a 3′-UTR comprising at least one poly(A) sequence or a polyadenylation signal, to a cell comprising the artificial nucleic acid molecule or the vector, to a pharmaceutical composition comprising the artificial nucleic acid molecule or the vector and to a kit comprising the artificial nucleic acid molecule, the vector and/or the pharmaceutical composition. The invention also relates to a method for increasing protein production from an artificial nucleic acid molecule and to the use of a 3′-UTR for a method for increasing protein production from an artificial nucleic acid molecule. Moreover, the invention concerns the use of the artificial nucleic acid molecule, the vector, the kit or the pharmaceutical composition as a medicament, as a vaccine or in gene therapy. |
| FILED | Tuesday, April 05, 2022 |
| APPL NO | 17/713533 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/145 (20130101) A61K 39/205 (20130101) A61K 48/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/67 (20130101) Original (OR) Class C12N 15/68 (20130101) C12N 15/85 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220307383 | Hayek et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Elia Hayek (Wrentham, Massachusetts); Tyler Frederick Hooper (Amesbury, Massachusetts); Megan Lynn Williams (Woodfin, North Carolina); Jonathan David Baldiga (Amesbury, Massachusetts) |
| ABSTRACT | A shroud assembly including a shroud support and an annular shroud is provided. The shroud assembly includes one or more pins for securing the annular shroud to the shroud support. The pins having a block capable of translating radially to allowing the shroud to expand and contract in the radial direction. A gas turbine engine having a compressor section, a combustion section, a turbine section and a shroud assembly is also provided. The shroud assembly includes one or more pins for securing the continuous shroud to the shroud support. The pins having a block capable of translating radially to allowing the shroud to expand and contract in the radial direction. Methods for assembling a shroud assembly structure in a gas turbine engine are also provided. |
| FILED | Monday, March 29, 2021 |
| APPL NO | 17/215539 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 9/04 (20130101) F01D 11/025 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2230/60 (20130101) F05D 2240/11 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220307807 | Allison et al. |
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| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Lucas Allison (Madison, Alabama); Michael H. Jones (Bedford, Indiana); Calvin Lawson (Springville, Indiana); Lucius A. Taylor, IV (Crane, Indiana) |
| ABSTRACT | Provided is a modular directional charge system that can be assembled in different configurations depending on the target. The system includes a removable energetic material, a molded plastic shell comprising a main body and a front cover, a removable fragmentation insert, a removable breaching insert, an initiator well insert, and initiator adapter nuts. The main body comprises an internal energetic material receiving compartment, a first and second tripod mount, a threaded adapter, and a pair of pin receivers, while the front cover comprises an internal removable insert compartment. The main body and front cover are held together with a multi-position adjustable toothed locking interface that adjustably permits the cover to intimately contact the energetic material when the internal removable insert compartment contains a fragmentation insert, a breaching insert, or no insert at all. A method of use is also provided. |
| FILED | Wednesday, March 16, 2022 |
| APPL NO | 17/696144 |
| CURRENT CPC | Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 23/14 (20130101) F42B 23/24 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220308004 | Chung et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Texas) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Jae-Hyun Chung (Seattle, Washington); Clement E. Furlong (Seattle, Washington); Seong-Joong Kahng (Seattle, Washington); Scott Soelberg (Seattle, Washington) |
| ABSTRACT | A carbon nanotube-based thin-film resistive sensor is disclosed. The sensor includes carbon nanotube film functionalized with sensing moieties and is configured for use in rapid screening for pathogens in point of care settings. |
| FILED | Thursday, May 28, 2020 |
| APPL NO | 17/613449 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 23/04 (20130101) B32B 27/40 (20130101) B32B 27/365 (20130101) B32B 2250/24 (20130101) B32B 2255/20 (20130101) B32B 2307/538 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/127 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220308026 | DeGreeff et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Lauryn E. DeGreeff (Washington, District of Columbia); Christopher J. Katilie (Washington, District of Columbia); Janet Crespo-Cajigas (Miami, Florida) |
| ABSTRACT | An apparatus having: a container, a first openable vessel within the container, an analyte within the first vessel, and a vapochromic sensor within the container. The vapochromic sensor changes color on contact with a vapor of the analyte. |
| FILED | Tuesday, February 15, 2022 |
| APPL NO | 17/672490 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/80 (20130101) G01N 21/783 (20130101) G01N 31/223 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220308125 | Sun et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nian-Xiang Sun (Winchester, Massachusetts); Neville Sun (Boston, Massachusetts); Xianfeng Lian (Boston, Massachusetts); Huaihao Chen (Boston, Massachusetts) |
| ABSTRACT | A solidly mounted resonator (SMR)-based magnetoelectric (ME) antenna comprises a substrate, a Bragg reflector disposed on the substrate, a magnetostrictive/piezoelectric ME composite element disposed on the Bragg reflector, a first electrically conductive contact and a second electrically conductive contact. The first contact is disposed between the Bragg reflector and the magnetostrictive/piezoelectric ME composite element and electrically coupled to a bottom surface of the magnetostrictive/piezoelectric ME composite element. The second contact is disposed on top of the magnetostrictive/piezoelectric ME composite element and electrically coupled to the top of the magnetostrictive/piezoelectric ME composite element. The magnetostrictive/piezoelectric ME composite element comprises a magnetorestrictive multilayer deposited on a piezoelectric layer. The magnetorestrictive multilayer produces an in-plane uniaxial magnetic anisotropy (UMA). The UMA is a twofold UMA that exhibits a symmetric radiation pattern. |
| FILED | Monday, March 28, 2022 |
| APPL NO | 17/656761 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/0286 (20130101) Original (OR) Class Impedance Networks, e.g Resonant Circuits; Resonators H03H 9/135 (20130101) H03H 9/175 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220308202 | Kendra |
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| FUNDED BY |
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| APPLICANT(S) | Leidos, Inc. (Reston, Virginia) |
| ASSIGNEE(S) | Leidos, Inc. (Reston, Virginia) |
| INVENTOR(S) | John R. Kendra (Arlington, Virginia) |
| ABSTRACT | A process and systems for constructing arbitrarily large virtual arrays using two or more collection platforms (e.g. AUX and MOV systems) having differing velocity vectors. Referred to as Motion Extended Array Synthesis (MXAS), the resultant imaging system is comprised of the collection of baselines that are created between the two collection systems as a function of time. Because of the unequal velocity vectors, the process yields a continuum of baselines over some range, which constitutes an offset imaging system (OIS) in that the baselines engendered are similar to those for a real aperture of the same size as that swept out by the relative motion, but which are offset by some (potentially very large) distance. |
| FILED | Tuesday, January 11, 2022 |
| APPL NO | 17/573346 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 13/46 (20130101) G01S 13/589 (20130101) G01S 13/904 (20190501) G01S 13/9023 (20130101) Original (OR) Class G01S 2013/0254 (20130101) G01S 2013/468 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220308239 | Bobrek et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | FAIRWINDS TECHNOLOGIES, LLC (Annapolis, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pavlo Bobrek (Bradenton, Florida); Timothy Hillner (Middletown, Delaware); Glenn Link (Odenton, Maryland) |
| ABSTRACT | A signal processing apparatus and method provides the ability to dynamically select a subset of subcarriers from a received frequency division multiplex (FDM), select which subsets of subcarriers are coherently combined per satellite, and translate the selected subcarriers into a FDM having a smaller bandwidth. There are at least two first phase aligners, a digital cross-connect, and at least two second phase aligners. The first and second phase aligners are configured to receive a pair of in-phase and quadrature pairs and provide automatic gain control and coherent combing of the pairs. The digital cross-connect is configured to receive the in-phase and quadrature pairs from the two phase aligners and associate any in-phase and quadrature pair with another. Preferably, the apparatus further includes dual front-end digital channelizers configured to convert signals into an in-phase and quadrature pairs which are input to the first phase aligners. |
| FILED | Monday, January 17, 2022 |
| APPL NO | 17/577308 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 19/44 (20130101) Original (OR) Class G01S 19/45 (20130101) G01S 19/423 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220308264 | ElKabbash et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Rochester (Rochester, New York); Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mohamed ElKabbash (Cambridge, Massachusetts); Chunlei Guo (Rochester, New York); Michael Hinczewski (Beachwood, Ohio); Giuseppe Strangi (Cleveland, Ohio) |
| ABSTRACT | An optical coating includes a first resonator with a broadband light absorber. A second resonator includes a narrowband light absorber which is disposed adjacent to and optically coupled to the broadband light absorber. The phase of light reflected from the first resonator slowly varies as a function of wavelength compared to the rapid phase change of the second resonator which exhibits a phase jump within the bandwidth of the broadband light absorber. A thin film optical beam spitter filter coating is also described. |
| FILED | Thursday, March 24, 2022 |
| APPL NO | 17/703618 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 1/005 (20130101) Original (OR) Class G02B 1/11 (20130101) G02B 5/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220308294 | MORGAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wesley MORGAN (Lake Oswego, Oregon); Srikant NEKKANTY (Chandler, Arizona); Todd R. COONS (Gilbert, Arizona); Gregorio R. MURTAGIAN (Phoenix, Arizona); Xiaoqian LI (Chandler, Arizona); Nitin DESHPANDE (Chandler, Arizona); Divya PRATAP (Hillsboro, Oregon) |
| ABSTRACT | Embodiments disclosed herein include photonics packages and systems. In an embodiment, a photonics package comprises a package substrate, where the package substrate comprises a cutout along an edge of the package substrate. In an embodiment, a photonics die is coupled to the package substrate, and the photonics die is positioned adjacent to the cutout. In an embodiment, the photonics package further comprises a receptacle for receiving a pluggable optical connector. In an embodiment, the receptacle is over the cutout. |
| FILED | Friday, March 26, 2021 |
| APPL NO | 17/214035 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/4204 (20130101) Original (OR) Class G02B 6/4261 (20130101) G02B 6/4278 (20130101) G02B 6/4292 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220308370 | Liang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| INVENTOR(S) | Guozhen Liang (Singapore, Singapore); Heqing Huang (Bronx, New York); Michal Lipson (New York, New York); Nanfang Yu (Fort Lee, New Jersey) |
| ABSTRACT | The systems described herein can be used to modulate either the phase, the amplitude, or both of an input light wave using micro-resonators to achieve desired degrees and/or types of modulation. |
| FILED | Thursday, April 02, 2020 |
| APPL NO | 16/838714 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/035 (20130101) Original (OR) Class G02F 1/0147 (20130101) G02F 1/212 (20210101) G02F 2201/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220308575 | Snaider et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Jordan M. Snaider (Bloomington, Indiana); Aaron Boyd Cole (Bloomington, Indiana); Benjamin Conley (Bloomington, Indiana) |
| ABSTRACT | The present invention provides a system for control and guidance of an unmanned aerial vehicle (UAV) using modulated laser light in radio frequency (RF) contested environments. The system enables the user to send light signal communications to the UAV from a handheld device. In one embodiment, where the handheld device is capable of being incorporated into a firearm fore-grip with built-in controls that allow for control of the UAV by a user in a shooting/aiming position. The UAV includes an optical array for detecting and receiving the light signal communications, as well as filtering systems for filtering out unnecessary image data for better control in different weather and time conditions, as well as an avoidance system to avoid objects and other UAVs when used in a swarm of UAVs. |
| FILED | Tuesday, March 29, 2022 |
| APPL NO | 17/706941 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 39/024 (20130101) B64C 2201/127 (20130101) B64C 2201/143 (20130101) B64C 2201/146 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/0016 (20130101) Original (OR) Class G05D 1/0022 (20130101) G05D 1/104 (20130101) G05D 1/1064 (20190501) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/005 (20130101) Transmission H04B 10/116 (20130101) H04B 10/524 (20130101) H04B 10/5057 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220308836 | Corron et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | USA as represented by the Secretary of the Army (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ned J. Corron (Madison, Alabama); Jonathan N. Blakely (Madison, Alabama) |
| ABSTRACT | An actively stabilized random number generator includes a random number generator and a feedback controller. The random number generator includes a chaotic physical circuit realizing an iterated function. The iterated function is configured to produce a trajectory of iterates and has an operating parameter β and a desired Markov operating point. A binary bit converter has a symbol function configured to produce binary symbols from the trajectory of iterates and a maximal kneading sequence. The feedback controller is configured to observe the maximal kneading sequence within the trajectory of iterates and adjust the operating parameter to the desired Markov operating point. |
| FILED | Tuesday, March 23, 2021 |
| APPL NO | 17/209680 |
| CURRENT CPC | Electric Digital Data Processing G06F 7/58 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220309192 | SHI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States as Represented by the Secretary of the Air Force (Rome, New York) |
| ASSIGNEE(S) | Government of the United States as Represented by the Secretary of the Air Force (Rome, New York) |
| INVENTOR(S) | YIYU SHI (GRANGER, Indiana); TRAVIS SCHULZE (ST. LOUIS, Missouri); KEVIN KWIAT (SARASOTA, Florida); CHARLES A. KAMHOUA (POTOMAC, Maryland) |
| ABSTRACT | In one embodiment, the invention is a method and apparatus for designing combinational logics with resistance to hardware Trojan induced data leakage. The invention solves the untrustworthy fabrication risk problem by introducing a design method such that even when the design is entirely known to an attacker and a data leakage Trojan is injected subsequently, no useful information can be obtained. This invention contains several methods as shown in several embodiments. The methods include randomized encoding of binary logic, converting any combinational binary logic into one with randomized encoding, and partitioning a randomized encoded logic for split manufacturing. |
| FILED | Thursday, June 02, 2022 |
| APPL NO | 17/830388 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/76 (20130101) Original (OR) Class G06F 21/755 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220310198 | Collins et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MASSACHUSETTS INSTITUTE OF TECHOLOGY (Cambridge, Massachusetts); THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | MASSACHUSETTS INSTITUTE OF TECHOLOGY (Cambridge, Massachusetts); THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts) |
| INVENTOR(S) | James Collins (Cambridge, Massachusetts); Regina Barzilay (Cambridge, Massachusetts); Jonathan Stokes (Cambridge, Massachusetts); Ian Andrews (Cambridge, Massachusetts); Daniel Collins (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure relates to antimicrobial compositions, particularly to antibiotic compositions; to methods for identification of antimicrobial compositions involving in silico prediction of antimicrobial activity; and to use of antimicrobial compositions and methods. |
| FILED | Wednesday, September 09, 2020 |
| APPL NO | 17/641704 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/433 (20130101) A61K 31/655 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Computer Systems Based on Specific Computational Models G06N 3/126 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/20 (20190201) G16B 15/30 (20190201) Original (OR) Class G16B 35/20 (20190201) G16B 40/20 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220310344 | Yee |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | Raytheon Company (Waltham, Massachusetts) |
| INVENTOR(S) | Chang J. Yee (Stow, Massachusetts) |
| ABSTRACT | A tool for the removal or installation of a fuse includes a first tool arm and a second tool arm pivotally mounted to the first tool arm about an axis. A second fuse holder spreader finger section is movable away from a first fuse holder spreader finger section and a second fuse pusher finger section is movable toward a first fuse pusher finger section in response to a first handle section being moved toward a second handle section. |
| FILED | Friday, March 26, 2021 |
| APPL NO | 17/213413 |
| CURRENT CPC | Tools or Bench Devices Not Otherwise Provided For, for Fastening, Connecting, Disengaging or Holding B25B 9/02 (20130101) B25B 27/0035 (20130101) Electric Switches; Relays; Selectors; Emergency Protective Devices H01H 85/0208 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220310566 | LI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaoqian LI (Chandler, Arizona); Wei LI (Chandler, Arizona); Santosh SHAW (Chandler, Arizona); Jingyi HUANG (Chandler, Arizona) |
| ABSTRACT | Embodiments disclosed herein include photonics packages. In an embodiment, a photonics package includes a photonics die and a plurality of v-grooves on the photonics die. A barrier structure proximate the plurality of v-grooves. |
| FILED | Friday, March 26, 2021 |
| APPL NO | 17/214083 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/12 (20130101) G02B 6/4201 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 25/075 (20130101) Original (OR) Class H01L 33/58 (20130101) H01L 33/62 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220311043 | YUSHIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sila Nanotechnologies Inc. (Alameda, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gleb YUSHIN (Atlanta, Georgia); Feixiang WU (Atlanta, Georgia); Hyea KIM (Atlanta, Georgia) |
| ABSTRACT | Lithium-ion batteries are provided that variously comprise anode and cathode electrodes, an electrolyte, a separator, and, in some designs, a protective layer. In some designs, at least one of the electrodes may comprise a composite of (i) Li2S and (ii) conductive carbon that is embedded in the core of the composite. In some designs, the protective layer may be disposed on at least one of the electrodes via electrolyte decomposition. Various methods of fabrication for lithium-ion battery electrodes and particles are also provided. |
| FILED | Monday, January 31, 2022 |
| APPL NO | 17/649418 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/136 (20130101) H01M 4/366 (20130101) H01M 4/0404 (20130101) H01M 4/0428 (20130101) H01M 4/0471 (20130101) H01M 4/1397 (20130101) H01M 4/5815 (20130101) H01M 10/052 (20130101) Original (OR) Class H01M 10/0568 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 10/70 (20130101) Technical Subjects Covered by Former US Classification Y10T 156/10 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220311059 | Patel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Xentris Wireless LLC (Addison, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vivek Patel (Elk Grove Village, Illinois); Rick Nowinski (Woodridge, Illinois) |
| ABSTRACT | A battery provided with at least one battery cell electrically coupled to a battery management circuitry, a power regulation and supply circuitry, a USB-C port controller, an E-marker integrated circuit and a USB interface. The E-marker integrated circuit provided in-line along a CC conductor between the USB-C port controller and the USB interface. The USB-C port controller is configured to enable the E-marker integrated circuit upon reception of a vendor defined message via the USB interface which enables a high power delivery mode between the battery and a device without the presence of a separate interconnecting E-marker cable there between. |
| FILED | Thursday, March 25, 2021 |
| APPL NO | 17/212945 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/4257 (20130101) Original (OR) Class Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors H01R 24/60 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 7/0013 (20130101) H02J 7/0042 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220311535 | Dawson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Naval Information Warfare Center Pacific (San Diego, California) |
| ASSIGNEE(S) | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (San Diego, California) |
| INVENTOR(S) | David Carlos Dawson (Lemon Grove, California); Ricardo Santoyo-Mejía (Chula Vista, California); Ronald B. Thompson (San Diego, California) |
| ABSTRACT | A process for an electronically steerable parasitic array (ESPAR) antenna includes operating the ESPAR antenna with a receiver in Normal Mode until an internal flag is generated by the receiver indicating jamming RF noise preventing Normal Mode operation, causing the ESPAR antenna to switch to Anti-jam Mode. Anti-jam Mode includes a Search Mode and a Track Mode. The ESPAR antenna is steered in Search Mode, causing the ESPAR antenna to beam in a circular pattern to locate a spatial direction of the jamming RF noise, identify the spatial direction of the jamming RF noise preventing Normal Mode operation, and place a null in the spatial direction of the jamming RF noise. The ESPAR antenna switches to Track Mode to maintain the null in the spatial direction of the jamming RF noise until the jamming RF noise is not present. The ESPAR antenna then returns to operating in Normal Mode. |
| FILED | Wednesday, March 24, 2021 |
| APPL NO | 17/210634 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 19/015 (20130101) Secret Communication; Jamming of Communication H04K 3/86 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220311782 | Mohammed et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Mayachitra, Inc. (Santa Barbara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tajuddin Manhar Mohammed (Goleta, California); Lakshmanan Nataraj (Chennai, India); Bangalore S. Manjunath (Santa Barbara, California); Shivkumar Chandrasekaran (Santa Barbara, California) |
| ABSTRACT | Systems and methods herein describe a malware visualization system that is configured to access a computer file, generate a first image of the computer file, determine a frequency count of bi-grams in the computer file, compute a discrete cosine transform (DCT) of the frequency count of bi-grams, generate a second image of the computer file based on the DCT of the frequency count of bi-grams, analyze the first image and the second image using an image classification neural network and generate a classification of the computer file. |
| FILED | Wednesday, March 24, 2021 |
| APPL NO | 17/211019 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6232 (20130101) G06K 9/6267 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 41/16 (20130101) H04L 63/145 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220311988 | Goodman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | H3D, Inc. (Ann Arbor, Michigan) |
| ASSIGNEE(S) | H3D, Inc. (Ann Arbor, Michigan) |
| INVENTOR(S) | David Goodman (Ann Arbor, Michigan); Brian Kitchen (Saline, Michigan) |
| ABSTRACT | An imaging system includes a detector configured to obtain radiation data from one or more sources and a controller. The controller is configured to define plurality of buffers based on at least one initial condition. The radiation data includes a plurality of events. The controller is configured to receive an individual event of the plurality of events and determine if the individual event falls within a designated current buffer. Each of the plurality of events in the current buffer is corrected for pose and aligned in a common two-dimensional space. The plurality of events in the current buffer are reconstructed into a three-dimensional space, the reconstruction being done once for each of the plurality of buffers. The controller is configured to create a three-dimensional image based in part on the reconstruction in the three-dimensional space. |
| FILED | Thursday, March 25, 2021 |
| APPL NO | 17/212614 |
| CURRENT CPC | Pictorial Communication, e.g Television H04N 13/156 (20180501) H04N 13/296 (20180501) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20220305416 | KELLY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Patrick KELLY (San Francisco, California); Jeffery J. HASLAM (Livermore, California); Mark MITCHELL (Dublin, California) |
| ABSTRACT | The present disclosure relates to a method for making a ceramic mini-tube configured for use in a fluid modification system. The method involves using an electrospinning system to receive a quantity of precursor solution. The electrospinning system creates an electric field which causes the precursor solution, when emitted, to be stretched into a fiber jet. The fiber jet is deposited on a collector resulting in a fiber mat. The fiber mat is removed from the collector, wherein the fiber mat is formed into a shape. The fiber mat is further processed so that the fiber mat retains a desired shape. A heat treatment operation is then performed to convert the fiber mat into a ceramic structure having the desired shape. |
| FILED | Tuesday, June 14, 2022 |
| APPL NO | 17/839694 |
| CURRENT CPC | Separation B01D 15/10 (20130101) B01D 24/10 (20130101) B01D 39/06 (20130101) Original (OR) Class B01D 46/2455 (20130101) B01D 71/024 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 35/06 (20130101) B01J 35/1076 (20130101) B01J 37/0009 (20130101) B01J 37/342 (20130101) Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/003 (20130101) D01D 5/0076 (20130101) Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles D10B 2505/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220305453 | Zheng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard F. Zheng (Lake Oswego, Oregon); Robert S. Wegeng (Richland, Washington); Paul H. Humble (Kennewick, Washington); Dustin D. Caldwell (Portland, Connecticut); Richard B. Diver (Albuquerque, New Mexico) |
| ABSTRACT | Reactors are provided that can include a first set of fluid channels and a second set of fluid channels oriented in thermal contact with the first set of fluid channels. The reactor assemblies can also provide where the channels of either one or both of the first of the set of fluid channels are non-linear. Other implementations provide for at least one of the first set of fluid channels being in thermal contact with a plurality of other channels of the second set of fluid channels. Reactor assemblies are also provided that can include a first set of fluid channels defining at least one non-linear channel having a positive function, and a second set of fluid channels defining at least another non-linear channel having a negative function in relation to the positive function of the one non-linear channel of the first set of fluid channels. Processes for distributing energy across a reactor are provided. The processes can include transporting reactants via a first set of fluid channels to a second set of fluid channels, and thermally engaging at least one of the first set of fluid channels with at least two of the second set of fluid channels. |
| FILED | Tuesday, June 07, 2022 |
| APPL NO | 17/834673 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/0013 (20130101) B01J 19/0093 (20130101) Original (OR) Class B01J 2219/00081 (20130101) B01J 2219/00788 (20130101) B01J 2219/00804 (20130101) B01J 2219/00873 (20130101) B01J 2219/00995 (20130101) Non-metallic Elements; Compounds Thereof; C01B 3/16 (20130101) C01B 3/38 (20130101) C01B 2203/063 (20130101) C01B 2203/066 (20130101) C01B 2203/0233 (20130101) C01B 2203/0283 (20130101) C01B 2203/0833 (20130101) C01B 2203/1241 (20130101) Solar Heat Collectors; Solar Heat Systems F24S 20/20 (20180501) F24S 90/00 (20180501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220305539 | Barber et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Shear Form, Inc. (Bryan, Texas) |
| ASSIGNEE(S) | Shear Form, Inc. (Bryan, Texas) |
| INVENTOR(S) | Robert E. Barber (Bryan, Texas); Karl T. Hartwig (Bryan, Texas) |
| ABSTRACT | A system and method provide a material with uniform micro-structure. In an embodiment, an equal channel angular extrusion system includes an interior mandrel. The interior mandrel includes an expanding shear material section and a contracting shear material section. In addition, the system includes a material. The material is disposed about a portion of the interior mandrel. Moreover, the system includes a pressure application device. The pressure application device applies pressure to the material to force the material to contact the expanding shear material section to provide an expanded post-shear material section. Pressure from the pressure application device applies pressure to the material to force the expanded post-shear material section to contact the contracting shear material section to provide a contracted shear material section. |
| FILED | Monday, June 13, 2022 |
| APPL NO | 17/838483 |
| CURRENT CPC | Manufacture of Metal Sheets, Wire, Rods, Tubes or Profiles, Otherwise Than by Rolling; Auxiliary Operations Used in Connection With Metal-working Without Essentially Removing Material B21C 23/001 (20130101) B21C 23/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220305551 | WATTS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Seth Evan WATTS (Collingswood, New Jersey); Nikola DUDUKOVIC (Hayward, California); Eric DUOSS (Danville, California) |
| ABSTRACT | The present disclosure relates to a plurality of powder particles configured to be joined in an additive manufacturing process to form a part. Each one of the powder particles has a determined three dimensional, non-spherical shape. The plurality of powder particles are further of dimensions enabling fitting individual ones of the powder particles in abutting relationship with one another. At least a subplurality of the powder particles each have a functionalized surface feature to enhance at least one of clustering or separation of the subplurality of powder particles. |
| FILED | Thursday, June 16, 2022 |
| APPL NO | 17/841769 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/05 (20220101) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220306460 | Elowson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael J. Elowson (Hillsborough, California); Rohan Dhall (El Cerrito, California); Adam Schwartzberg (Richmond, California); Shaul Aloni (El Cerrito, California); Stefano Cabrini (Albany, California) |
| ABSTRACT | This disclosure provides methods and apparatus related to thin films. In one aspect, a silicon wafer with a first silicon nitride layer disposed on a first side of the silicon wafer and a second silicon nitride layer disposed on a second side of the silicon wafer is provided. A first side of the first silicon nitride layer is disposed on the first side of the silicon wafer. The second silicon nitride layer is patterned. The silicon wafer is etched to expose the first side of the first silicon nitride layer. A polymer is deposited on a second side of the first silicon nitride layer. A first ceramic layer is deposited on the polymer disposed on the second side of the first silicon nitride layer using an atomic layer deposition process. The first silicon nitride layer and the polymer are etched to expose a first side of the first ceramic layer. |
| FILED | Tuesday, March 22, 2022 |
| APPL NO | 17/700780 |
| CURRENT CPC | Microstructural Devices or Systems, e.g Micromechanical Devices B81B 3/0021 (20130101) B81B 2203/0127 (20130101) Processes or Apparatus Specially Adapted for the Manufacture or Treatment of Microstructural Devices or Systems B81C 1/00158 (20130101) Original (OR) Class B81C 2201/0132 (20130101) B81C 2201/0133 (20130101) B81C 2201/0176 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220306476 | Cao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois); National Energy Technology Laboratory (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qing Cao (Champaign, Illinois); Fufei An (Urbana, Illinois); Christopher Matranga (Pittsburgh, Pennsylvania); Congjun Wang (Bethel Park, Pennsylvania); Viet Hung Pham (Bethel Park, Pennsylvania) |
| ABSTRACT | Amorphous two-dimensional graphene-like carbon films provide benefits to a variety of applications due to advantageous electrical, mechanical, and chemical properties. Methods are provided to efficiently and cheaply create high-quality amorphous two-dimensional carbon films with embedded graphene-like nanocrystallites using coal as a precursor. These methods employ solution-phase deposition of coal-derived graphene-containing quantum dots followed by relatively low-temperature annealing/crosslinking of the quantum dots to form a single two-dimensional layer of carbon that includes a plurality of randomly-oriented discrete graphene domains connected to each other via amorphous carbon regions. Multi-layer films can be easily created by repeating the deposition and annealing processes. Two-dimensional carbon films formed in this manner exhibit improved properties when compared to crystalline graphene sheets and have properties especially suited to use as the storage medium of memristors. Further processing can result in large free-standing two-dimensional graphene-like carbon thin films that can be used as membranes or for other applications. |
| FILED | Tuesday, March 29, 2022 |
| APPL NO | 17/707521 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/194 (20170801) Original (OR) Class C01B 2204/02 (20130101) C01B 2204/04 (20130101) C01B 2204/22 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/82 (20130101) C01P 2004/04 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/51 (20130101) H01L 45/149 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220306484 | Zur Loye et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of South Carolina (Columbia, South Carolina); National Institute For Materials Science (Tsukuba-shi, Japan) |
| ASSIGNEE(S) | University of South Carolina (Columbia, South Carolina); National Institute For Materials Science (Tsukuba-shi, Japan) |
| INVENTOR(S) | Hans-Conrad Zur Loye (Columbia, South Carolina); Yoshihiro Tsujimoto (Tsukuba, Japan) |
| ABSTRACT | Single crystals of a new noncentrosymmetric polar oxysulfide SrZn2S2O (s.g. Pmn21) grown in a eutectic KF-KCl flux with unusual wurtzite-like slabs consisting of close-packed corrugated double layers of ZnS3O tetrahedra vertically separated from each other by Sr atoms and methods of making same. |
| FILED | Friday, June 10, 2022 |
| APPL NO | 17/837371 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 2/22 (20130101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 9/006 (20130101) Original (OR) Class Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/3551 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220306763 | Pasqualini et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Renata Pasqualini (New Brunswick, New Jersey); Wadih Arap (New Brunswick, New Jersey); Fernanda Iamassaki Staquicini (New Brunswick, New Jersey); Fortunato Ferrara (Santa Fe, New Mexico); Sara D'Angelo (Santa Fe, New Mexico); Andrew R.M. Bradbury (Santa Fe, New Mexico) |
| ABSTRACT | Isolated or recombinant EphA5 or GRP78 targeting antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer. A method of rapidly identifying antibodies or antibody fragments for the treatment of cancer using a combination of in vitro and in vivo methodologies is also provided. |
| FILED | Friday, February 04, 2022 |
| APPL NO | 17/592828 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/07 (20130101) A61K 39/3955 (20130101) A61K 39/39558 (20130101) A61K 47/6803 (20170801) A61K 47/6817 (20170801) A61K 47/6843 (20170801) A61K 47/6849 (20170801) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/18 (20130101) C07K 16/28 (20130101) C07K 16/30 (20130101) Original (OR) Class C07K 16/3023 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1037 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57423 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220306914 | YANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania); Lehigh University (Bethlehem, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shu YANG (Blue Bell, Pennsylvania); Jason Christopher JOLLY (Philadelphia, Pennsylvania); Gaoxiang WU (Philadelphia, Pennsylvania); Anand JAGOTA (Bethlehem, Pennsylvania); Zhenping HE (Chalfont, Pennsylvania); Hyesung CHO (Philadelphia, Pennsylvania) |
| ABSTRACT | The invention concerns adhesives comprising a polymer network capable of conversion between two different elastic modulus states with essentially no residual stress evolved in conversion between the two different elastic modulus states, wherein the polymer network comprises either or both of (i) poly(2-hydroxy ethyl methacrylate) (PHEMA) hydrogel and/or a copolymers thereof, and (ii) a shape memory polymer. The invention also concerns methods of using such adhesives. |
| FILED | Friday, January 31, 2020 |
| APPL NO | 17/427226 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/24 (20130101) C08J 3/075 (20130101) C08J 2333/10 (20130101) Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 11/06 (20130101) C09J 133/066 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220307105 | Aksenova et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Pioneer Astronautics (Lakewood, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Diana Aksenova (Lakewood, Colorado); Steven Fatur (Boulder, Colorado); Alex Román (Golden, Colorado); Mark Berggren (Lakewood, Colorado); Robert Zubrin (Lakewood, Colorado) |
| ABSTRACT | Systems and methods for recovering neodymium and other related rare earth elements from permanent magnets and/or various ore compositions are presented herein. In one embodiment, a method of recovering a rare earth element (REE) from a permanent magnet material and/or a mined ore composition (collectively “work material”) is presented. The method includes converting the work material to a higher surface area form, treating the converted work material with an aqueous solution of alkaline carbonates to dissolve the REE, filtering the treated and converted work material to yield a filtrate, and treating the filtrate with at least one of a precipitating agent or a precipitating condition to form REE solids. The aqueous solution of alkaline carbonates comprises at least one of potassium carbonate, potassium bicarbonate, or dissolved carbon dioxide. |
| FILED | Thursday, March 24, 2022 |
| APPL NO | 17/703339 |
| CURRENT CPC | Production and Refining of Metals; Pretreatment of Raw Materials C22B 3/12 (20130101) Original (OR) Class C22B 3/22 (20130101) C22B 59/00 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 7/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220307109 | Spradling et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Millennitek, LLC (Knoxville, Tennessee) |
| ASSIGNEE(S) | Millennitek, LLC (Knoxville, Tennessee) |
| INVENTOR(S) | Andrew M. Spradling (Knoxville, Tennessee); Lawrence W. Townsend (Knoxville, Tennessee); Kevin J. Hughes (Knoxville, Tennessee) |
| ABSTRACT | A method of forming cemented tungsten tetraboride, by combining tungsten and boron in a molar ratio of from about 1:6 to about 1:12, respectively, and firing the combined tungsten and boron in a hexagonal boron nitride crucible at a temperature of from about 1600 C to about 2000 C, to form tungsten tetraboride, milling the tungsten tetraboride to a powder, adding a metal binder to the tungsten tetraboride powder to produce a metal-tungsten tetraboride mixture, compressing the metal-tungsten tetraboride mixture, and sintering the compressed metal-tungsten tetraboride mixture to form cemented tungsten tetraboride. |
| FILED | Monday, June 06, 2022 |
| APPL NO | 17/805551 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 35/04 (20130101) Alloys C22C 1/051 (20130101) Original (OR) Class C22C 29/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220307148 | Fatur et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Pioneer Astronautics (Lakewood, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven Fatur (Boulder, Colorado); Alex Román (Golden, Colorado); Diana Aksenova (Lakewood, Colorado); Mark Berggren (Lakewood, Colorado); Robert Zubrin (Lakewood, Colorado) |
| ABSTRACT | Systems and methods for recovering cobalt and other valuable metals from cobalt permanent magnets of various compositions, such as samarium cobalt magnets, are presented herein. In one embodiment, a method includes converting the permanent magnet material to a higher surface area form, such as a powder. The method also includes treating the converted permanent magnet material with an aqueous solution of ammonium carbonate to form a mixture (e.g., a slurry) that includes dissolved cobalt. In some embodiments, the method includes exposing the mixture to an oxidant to oxidize metallic constituents and form soluble species. The method also includes filtering the mixture to yield a filtrate and electroplating the cobalt onto a cathode from the filtrate. |
| FILED | Thursday, March 24, 2022 |
| APPL NO | 17/703137 |
| CURRENT CPC | Processes for the Electrolytic Production, Recovery or Refining of Metals; Apparatus Therefor C25C 1/08 (20130101) Original (OR) Class C25C 1/12 (20130101) C25C 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220307324 | Kontras |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| INVENTOR(S) | Evan A. Kontras (Kansas City, Missouri) |
| ABSTRACT | A shrouded screw apparatus includes an outer tube, a telescoping inner tube, an auger bit, and an anti-rotation pin. The outer tube has a first sidewall defining a first interior chamber. The first sidewall has an opening defined therethrough. The inner tube is positioned in the first interior chamber. The inner tube has a second sidewall defining a second interior chamber. The second sidewall has a longitudinal groove defined therein. The inner tube is configured to extend from and retract within the first interior chamber of the outer tube. The auger bit is positioned in the second interior chamber and is rotatably coupled to the inner tube. The anti-rotation pin is coupled to the first sidewall of the outer tube and extends inwardly into the first interior chamber. The pin engages the longitudinal groove of the inner tube. |
| FILED | Wednesday, June 15, 2022 |
| APPL NO | 17/841401 |
| CURRENT CPC | Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 10/22 (20130101) Original (OR) Class E21B 10/44 (20130101) E21B 10/62 (20130101) E21B 17/07 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220307375 | Chakrabarti et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Suryarghya Chakrabarti (Niskayuna, New York); Jing Li (Niskayuna, New York) |
| ABSTRACT | A turbine damper may be provided that may include an elongated body sized to fit inside a turbine blade, the elongated body elongated along a radial direction of the turbine blade relative to a rotation axis of the turbine blade, and plural dampening masses coupled with the elongated body and disposed at different locations along the radial direction. The plural dampening masses may be one or more of sized to dampen different vibration modes of the turbine blade, or moveable relative to and along the elongated body in the radial direction. |
| FILED | Tuesday, June 07, 2022 |
| APPL NO | 17/834361 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/16 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/30 (20130101) F05D 2260/96 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220307778 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Evelyn N. Wang (Cambridge, Massachusetts); Lin Zhao (Revere, Massachusetts); Bikram Bhatia (Cambridge, Massachusetts); Xiangyu Li (Cambridge, Massachusetts); Arny Leroy (Montreal, Canada); Kyle Wilke (Boston, Massachusetts); Lenan Zhang (Cambridge, Massachusetts); Jeffrey Youngblood (Crawfordsville, Indiana); Rodney Trice (Xenia, Ohio); Chad T. Wilson (Cambridge, Massachusetts); Olivia Brandt (West Lafayette, Indiana); Rodrigo Orta Guerra (West Lafayette, Indiana) |
| ABSTRACT | Devices and methods for fabrication of a multiscale porous high-temperature heat exchanger for high-temperature and high-pressure applications are disclosed. The heat exchanger can include a core with macrochannels formed in a checkerboard pattern to facilitate alternative flow of working fluid having hot and cold temperatures between adjacent macrochannels. Each macrochannel can include a two-dimensional microchannel array that further distributes flow throughout the heat exchanger to enhance heat transfer and mechanical strength without significant pressure drop penalty. The heat exchanger can further include a header integrated therewith to distribute working fluid flowing through the heat exchanger through the outlets such that it flows evenly therethrough. Methods of fabricating heat exchangers of this nature are also disclosed. |
| FILED | Monday, March 28, 2022 |
| APPL NO | 17/705693 |
| CURRENT CPC | Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 9/0062 (20130101) Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 9/02 (20130101) Original (OR) Class F28F 21/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220308471 | SAMPAYAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California); Opcondys, Inc. (Manteca, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen SAMPAYAN (Livermore, California); Paulius Vytautas GRIVICKAS (Pleasanton, California); Kristin Cortella SAMPAYAN (Manteca, California) |
| ABSTRACT | Techniques, systems, and devices are disclosed for implementing a photoconductive device performing bulk conduction. In one exemplary aspect, a photoconductive device is disclosed. The device includes a light source configured to emit light; a crystalline material positioned to receive the light from the light source, wherein the crystalline material is doped with a dopant that forms a mid-gap state within a bandgap of the crystalline material to control a recombination time of the crystalline material; a first electrode coupled to the crystalline material to provide a first electrical contact for the crystalline material, and a second electrode coupled to the crystalline material to provide a second electrical contact for the crystalline material, wherein the first and the second electrodes are configured to establish an electric field across the crystalline material, and the crystalline material is configured to exhibit a substantially linear transconductance in response to receiving the light. |
| FILED | Monday, June 06, 2022 |
| APPL NO | 17/805645 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/4295 (20130101) Electrography; Electrophotography; Magnetography G03G 5/04 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/09 (20130101) H01L 31/101 (20130101) H01L 31/173 (20130101) Pulse Technique H03K 17/78 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220308544 | Wilde et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | HEWLETT PACKARD ENTERPRISE DEVELOPMENT LP (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Torsten Wilde (Berlin, Germany); Jeffrey C. Hanson (Lakewood, Ohio); Aamir Arshad Rashid (Sharon, Massachusetts); Michael McKay (Wellesley, Canada) |
| ABSTRACT | In some examples, a controller dynamically configures a property associated with monitoring performed by an agent. The controller stores, in a repository, metadata relating to the agent. The controller receives, from the agent, first sensor data that excludes the metadata, and uses indexing information in the first sensor data to retrieve the metadata from the repository. |
| FILED | Monday, March 29, 2021 |
| APPL NO | 17/215238 |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/0428 (20130101) Original (OR) Class G05B 2219/24015 (20130101) G05B 2219/25068 (20130101) Electric Digital Data Processing G06F 16/164 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220310389 | MANGUM et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Stanley MANGUM (Englewood, Colorado); William Edwin MCMAHON (Denver, Colorado); Emily Lowell WARREN (Golden, Colorado); San THEINGI (Golden, Colorado) |
| ABSTRACT | Described herein are systems and methods of utilizing nanochannels generated in the sacrificial layer of a semiconductor substrate to increase epitaxial lift-off speeds and facilitate reusability of GaAs substrates. The provided systems and methods may utilize unique nanochannel geometries to increase the surface area exposed to the etchant and further decrease etch times. |
| FILED | Monday, March 28, 2022 |
| APPL NO | 17/656762 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/02395 (20130101) H01L 21/02463 (20130101) H01L 21/02496 (20130101) Original (OR) Class H01L 21/7813 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220310864 | ESCARRA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (New Orleans, Louisiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew David ESCARRA (New Orleans, Louisiana); Kazi M. ISLAM (New Orleans, Louisiana); Ji YAPING (New Orleans, Louisiana); Daniel CODD (New Orleans, Louisiana); David M. BAR-OR (New Orleans, Louisiana); Jacqueline C. FAILLA (New Orleans, Louisiana); Claire C. DAVIS (New Orleans, Louisiana); Maxwell W. WOODY (New Orleans, Louisiana) |
| ABSTRACT | A spectrum-splitting concentrator photovoltaic (CPV) module utilizes direct fluid cooling of photovoltaic cells in which an array of photovoltaic cells is fully immersed in a flowing heat transfer fluid. Specifically, at least a portion of both the front face and the rear face of each photovoltaic cell comes into direct contact with heat transfer fluid, thereby enhancing coupling of waste heat out of the photovoltaic cells and into the heat transfer fluid. The CPV module is designed to maximize transmission of infrared light not absorbed by the photovoltaic cells, and therefore may be combined with a thermal receiver that captures the transmitted infrared light as part of a hybrid concentrator photovoltaic-thermal system. |
| FILED | Sunday, June 14, 2020 |
| APPL NO | 17/619187 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/047 (20141201) H01L 31/0521 (20130101) H01L 31/0549 (20141201) Original (OR) Class Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 40/22 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220311014 | ROUMI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Farshid ROUMI (Pasadena, California); Mahshid Roumi (Pasadena, California) |
| ABSTRACT | Provided herein are three-dimensional ion transport networks and current collectors for electrodes of electrochemical cells. Exemplary electrodes include interconnected layers and channels including an electrolyte to facilitate ion transport. Exemplary electrodes also include three dimensional current collectors, such as current collectors having electronically conducting rods, electronically conducting layers or a combination thereof. |
| FILED | Tuesday, January 25, 2022 |
| APPL NO | 17/583679 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/13 (20130101) H01M 4/78 (20130101) Original (OR) Class H01M 4/80 (20130101) H01M 4/366 (20130101) H01M 4/742 (20130101) H01M 10/054 (20130101) H01M 10/0525 (20130101) H01M 10/0565 (20130101) H01M 12/08 (20130101) H01M 50/409 (20210101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220311051 | Saito et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tomonori Saito (Knoxville, Tennessee); Michelle Lehmann (Knoxville, Tennessee); Jagjit Nanda (Knoxville, Tennessee) |
| ABSTRACT | A solid electrolyte composition comprising the following components: (i) an organic polymer comprising a polymeric backbone and pendant groups, wherein at least a portion of the pendant groups contain an anionic group associated with a first metal ion; (ii) a solvent homogeneously incorporated in the polymer to result in a polymer gel system; and (iii) a metal salt dissolved in the solvent in a molar concentration of 0.05 M to 1.5 M and containing a second metal ion associated with an anion, provided that the first and second metal ions are the same. Also described herein are solid-state batteries comprising: a) an anode; (b) a cathode; and (c) the solid electrolyte composition described above. |
| FILED | Thursday, March 24, 2022 |
| APPL NO | 17/703371 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0525 (20130101) H01M 10/0565 (20130101) Original (OR) Class H01M 2300/0082 (20130101) H01M 2300/0085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220311053 | SANTHANAGOPALAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shriram SANTHANAGOPALAN (Broomfield, Colorado); Ryan Ray BROW (Denver, Colorado) |
| ABSTRACT | The present disclosure includes bridged bicyclic compounds and other non-flat organic molecules that have the ability to solvate lithium salts in higher concentrations without significant changes to the electrolyte viscosity which assists in improving the fast charge capability of lithium-ion cells. Using non-flat polar molecules may enable higher solubility of the salts while minimizing viscosity changes to the electrolyte. In some embodiments, the fused bicyclic compound is 7-oxabicyclo[2.2.1]heptane-2-carbonitrile (BHCN). |
| FILED | Friday, March 25, 2022 |
| APPL NO | 17/704145 |
| CURRENT CPC | Heterocyclic Compounds C07D 493/08 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0525 (20130101) H01M 10/0567 (20130101) Original (OR) Class H01M 10/0568 (20130101) H01M 10/0569 (20130101) H01M 2300/0037 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220311378 | ESCARRA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (New Orleans, Louisiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew David ESCARRA (New Orleans, Louisiana); Luke ARTZT (New Orleans, Louisiana); Yaping JI (New Orleans, Louisiana); Daniel CODD (New Orleans, Louisiana); Matthew BARRIOS (New Orleans, Louisiana); Kazi M. ISLAM (New Orleans, Louisiana); David M. BAR-OR (New Orleans, Louisiana); Jacqueline C. FAILLA (New Orleans, Louisiana); Claire C. DAVIS (New Orleans, Louisiana); Maxwell W. WOODY (New Orleans, Louisiana) |
| ABSTRACT | A hybrid receiver for a concentrator photovoltaic-thermal power system combines a concentrator photovoltaic (CPV) module and a thermal module that converts concentrated sunlight into electrical energy and thermal heat. Heat transfer fluid flowing through a cooling block removes waste heat generated by photovoltaic cells in the CPV module. The heat transfer fluid then flows through a helical tube illuminated by sunlight that misses the CPV module. Only one fluid system is used to both remove the photovoltaic-cell waste heat and capture high-temperature thermal energy from sunlight. Fluid leaving the hybrid receiver can have a temperature greater than 200° C., and therefore may be used as a source of process heat for a variety of commercial and industrial applications. The hybrid receiver can maintain the photovoltaic cells at temperatures below 110° C. while achieving overall energy conversion efficiencies exceeding 80%. |
| FILED | Sunday, June 14, 2020 |
| APPL NO | 17/619185 |
| CURRENT CPC | Solar Heat Collectors; Solar Heat Systems F24S 10/744 (20180501) F24S 20/20 (20180501) F24S 70/65 (20180501) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/06 (20130101) Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 40/44 (20141201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220311762 | Bhuyan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho); The Research Foundation for The State University of New York (Buffalo, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arupjyoti Bhuyan (Idaho Falls, Idaho); Zhi Sun (Clarence Center, New York); Sarankumar Balakrishnan (San Jose, California) |
| ABSTRACT | Systems, devices, and methods are described for millimeter wave device authentication. A system may include one or more access points. Each access point of the one or more access points is configured to extract, from one or more beam patterns generated via a client device, a beam feature associated with the client device. Each access point may also be configured to transmit the beam feature. The system may also include a server communicatively coupled to the one or more access points and including a database for storing known beam features. The server may be configured to receive the beam feature associated with the client device from at least one access point of the one or more access points. Also, the server may be configured to authenticate the client device in response to the received beam feature matching a known beam feature stored in the at least one database. |
| FILED | Friday, June 26, 2020 |
| APPL NO | 17/596863 |
| CURRENT CPC | Transmission H04B 7/0617 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/0861 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20220305049 | GLASS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | TEGA Therapeutics, Inc. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles GLASS (San Diego, California); Bryan THACKER (San Diego, California); Jeffrey D. ESKO (San Diego, California) |
| ABSTRACT | Abstract: Provided herein are methods of producing heparin and heparan sulfate from modified cells, such as modified MST cells and modified basophil neoplastic cells, and compositions comprising heparin and heparan sulfate isolated from modified cells. In some embodiments, methods herein comprise culturing a genetically modified cell line comprising at least one of a mastocytoma cell line and a basophil neoplastic cell line; and isolating the heparin or heparan sulfate from the cell line. |
| FILED | Thursday, August 27, 2020 |
| APPL NO | 17/638760 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/727 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/02 (20180101) A61P 11/00 (20180101) A61P 29/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0693 (20130101) C12N 15/52 (20130101) C12N 15/86 (20130101) C12N 2510/02 (20130101) C12N 2740/15043 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/26 (20130101) Enzymes C12Y 208/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220305183 | Gage et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | INNAVASC MEDICAL, INC. (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shawn M. Gage (Raleigh, North Carolina); Craig Nichols (Durham, North Carolina); Joseph Knight (Durham, North Carolina); Juan Chiossone (Raleigh, North Carolina); Peter Lawson (Durham, North Carolina); Samantha Busch (Indian Land, South Carolina); Brian Walsh (Charlotte, North Carolina) |
| ABSTRACT | A cannulation chamber is provided for use with an arteriovenous graft including a flexible conduit. The cannulation chamber comprises an elongated body defining an annular passageway having a longitudinal axis extending between a first end and a second end. The body receives and surrounds the conduit in the passageway. The body comprises a self-sealing material and a cannulation port that exposes the self-sealing material. A flexible resilient elongated back plate is embedded in the body of the cannulation chamber such that the back plate extends generally parallel with and may partially surround the passageway. The back plate is formed of a substantially rigid material such that when a needle is inserted through the cannulation port and the self-sealing material, the needle is inhibited or prevented from extending through the back plate. |
| FILED | Thursday, December 30, 2021 |
| APPL NO | 17/566428 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/3655 (20130101) Original (OR) Class A61M 1/3661 (20140204) A61M 39/04 (20130101) A61M 39/0208 (20130101) A61M 2039/0036 (20130101) A61M 2205/0216 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220305279 | KEIDAR et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The George Washington University (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | MICHAEL KEIDAR (Baltimore, Maryland); DAYUN YAN (Ashburn, Virginia); XIAOLIANG YAO (Fairfax, Virginia); Li LIN (Arlington, Virginia); Vikas SONI (Washington, District of Columbia); Jonathan SHERMAN (Potomac, Maryland) |
| ABSTRACT | A method and system of sensitization of cancerous cells in a volume is disclosed. A plasma tube including a pair of electrodes coupled to a power supply is provided. The plasma tube generates a plasma jet between the electrodes. A controller is coupled to a power supply to control a discharge voltage to the electrodes to generate the plasma jet and direct an electro-magnetic field at the volume having cancerous cells and normal cells for a sufficient time to sensitize the cancer cells. A treatment device applies a treatment such as TMZ to the sensitized cancer cells after the cancer cells are sensitized by the electro-magnetic field. |
| FILED | Thursday, July 09, 2020 |
| APPL NO | 17/620032 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 2018/00071 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/495 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 2/004 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220305465 | Lou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yang Lou (Tempe, Arizona); Jingyue Liu (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yang Lou (Tempe, Arizona); Jingyue Liu (Scottsdale, Arizona) |
| ABSTRACT | A nanocatalyst including single atoms of platinum dispersed on a nanoscale metal oxide, and the nanocatalyst comprises 0.01 wt % to 1 wt % platinum. Preparing the nanocatalyst includes combining a solution comprising a nanoscale metal oxide and a compound containing a Group 10 metal to yield a mixture, aging the mixture for a length of time, filtering the mixture to yield a solid, washing the solid to eliminate water soluble anions, and calcining the solid to yield a nanocatalyst including single atoms or clusters of atoms of the Group 10 metal on the nanoscale metal oxide. |
| FILED | Monday, June 06, 2022 |
| APPL NO | 17/833285 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/04 (20130101) B01J 23/10 (20130101) B01J 23/42 (20130101) Original (OR) Class B01J 23/83 (20130101) B01J 23/745 (20130101) B01J 35/0013 (20130101) B01J 37/06 (20130101) B01J 37/088 (20130101) B01J 37/0221 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220306496 | Mitra et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | New Jersey Institute of Technology (Newark, New Jersey) |
| ASSIGNEE(S) | New Jersey Institute of Technology (Newark, New Jersey) |
| INVENTOR(S) | Somenath Mitra (Bridgewater, New Jersey); Indrani Gupta (Harrison, New Jersey); Joydeep Chakraborty (College Station, Texas) |
| ABSTRACT | Direct contact membrane distillation (DCMD) was used to generate high purity water from bacteria and endotoxin-contaminated water. The DCMD system includes a nanocarbon-coated membrane. Exemplary nanocarbon-coated membranes include a layer of carbon nanotubes immobilized relative to a polytetrafluorethylene surface (CNIM), a layer of carboxylate functionalized carbon nanotubes immobilized in the PTFE (CNIM-COOH), and a layer of graphene oxide immobilized in the PTFE (GOIM). The nanocarbon-immobilized membranes are effective in generating ultrapure, medical grade water. |
| FILED | Tuesday, March 22, 2022 |
| APPL NO | 17/700741 |
| CURRENT CPC | Separation B01D 67/0088 (20130101) B01D 69/02 (20130101) B01D 71/021 (20130101) B01D 71/36 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/447 (20130101) Original (OR) Class C02F 2103/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220306534 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Guoqiang Li (Baton Rouge, Louisiana); Harper Meng (Baton Rouge, Louisiana) |
| ABSTRACT | A composition comprising thermoset polymer, shape memory polymer to facilitate macro scale damage closure, and a means for molecular scale healing is disclosed; the composition has the ability to resolve structural defects by a bio-mimetic close-then heal process. In use, the shape memory polymer serves to bring surfaces of a structural defect into approximation, whereafter use of the means for molecular scale healing allowed for movement of the healing means into the defect and thus obtain molecular scale healing. The means for molecular scale healing can be a thermoplastic such as fibers, particles or spheres which are used by heating to a level at or above the thermoplastic's melting point, then cooling of the composition below the melting temperature of the thermoplastic. Compositions of the invention have the ability to not only close macroscopic defects, but also to do so repeatedly even if another wound/damage occurs in a previously healed/repaired area. |
| FILED | Tuesday, May 10, 2022 |
| APPL NO | 17/740779 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 73/18 (20130101) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 20/1037 (20130101) C04B 26/04 (20130101) C04B 26/16 (20130101) Original (OR) Class C04B 26/26 (20130101) C04B 28/02 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/10 (20130101) C08G 18/664 (20130101) C08G 18/3206 (20130101) C08G 18/4238 (20130101) C08G 18/7671 (20130101) C08G 2350/00 (20130101) Compositions of Macromolecular Compounds C08L 75/04 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 6/70 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220306677 | Ad et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Omer Ad (New Haven, Connecticut); Kyle S. Hoffman (New Haven, Connecticut); Andrew G. Cairns (New Haven, Connecticut); Aaron L. Featherston (New Haven, Connecticut); Scott J. Miller (New Haven, Connecticut); Dieter Soll (New Haven, Connecticut); Alanna Schepartz (Berkeley, California) |
| ABSTRACT | Compositions and methods of making hybrid polypeptides and other polymers are disclosed. For example, functionalized tRNA having a functional molecule including a benzoic acid or benzoic acid derivative acylated to the 3′ nucleotide of a tRNA are provided. Functionalized tRNA having a functional molecule including a malonic acid or malonic acid derivative acylated to the 3′ nucleotide of a tRNA are also provided. Methods of using the functionalized tRNA for making compounds including the functional molecule are also provided. The methods typically include providing or expressing a messenger RNA (mRNA) encoding the target polypeptide in a translation system including one or more functionalized tRNA wherein each functionalized tRNA recognizes at least one codon such that its functional molecule is incorporated into the polypeptide or other polymer during translation. The incorporation of the functional molecule can occur in vitro in a cell-free translation system, or in vivo in a host cell. |
| FILED | Thursday, June 04, 2020 |
| APPL NO | 17/616948 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/02 (20130101) Original (OR) Class Peptides C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) C12N 2310/351 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220306792 | Coates et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CORNELL UNIVERSITY (lthaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Geoffrey W. Coates (Lansing, New York); Anne M. Lapointe (Ithaca, New York); Kristine Klimovica (St. Paul, Minnesota); Ting-Wei Lin (Ithaca, New York); James M. Eagan (Fairlawn, Ohio) |
| ABSTRACT | Provided are graft copolymers, methods of making graft copolymers, polymer blends made from graft copolymers, methods of making polymer blends, and articles made from graft copolymers and blends thereof. The graft copolymers may be made from ethylene and isotactic polypropylene. The polymer blends may be made from semi-crystalline polyethylene, polypropylene, and a graft copolymer of the present disclosure. |
| FILED | Monday, September 14, 2020 |
| APPL NO | 17/642461 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 255/02 (20130101) Original (OR) Class Compositions of Macromolecular Compounds C08L 51/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220306914 | YANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania); Lehigh University (Bethlehem, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shu YANG (Blue Bell, Pennsylvania); Jason Christopher JOLLY (Philadelphia, Pennsylvania); Gaoxiang WU (Philadelphia, Pennsylvania); Anand JAGOTA (Bethlehem, Pennsylvania); Zhenping HE (Chalfont, Pennsylvania); Hyesung CHO (Philadelphia, Pennsylvania) |
| ABSTRACT | The invention concerns adhesives comprising a polymer network capable of conversion between two different elastic modulus states with essentially no residual stress evolved in conversion between the two different elastic modulus states, wherein the polymer network comprises either or both of (i) poly(2-hydroxy ethyl methacrylate) (PHEMA) hydrogel and/or a copolymers thereof, and (ii) a shape memory polymer. The invention also concerns methods of using such adhesives. |
| FILED | Friday, January 31, 2020 |
| APPL NO | 17/427226 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/24 (20130101) C08J 3/075 (20130101) C08J 2333/10 (20130101) Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 11/06 (20130101) C09J 133/066 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220307013 | Mali et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Prashant Mali (La Jolla, California); Kyle M. Ford (La Jolla, California); Nathan Palmer (La Jolla, California); Rebecca Panwala (La Jolla, California) |
| ABSTRACT | The disclosure provides for screening methodologies using gene fragment overexpression that provide for the identification of peptide sequences which can modulate the functional regions of proteins of interests, and uses thereof. The disclosure further relates to peptide, polypeptide and polynucleotide identified by the methods of the disclosure, compositions containing such peptide, polypeptide and polynucleotides and uses thereof. |
| FILED | Friday, August 28, 2020 |
| APPL NO | 17/638428 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/71 (20130101) C07K 14/82 (20130101) C07K 14/4703 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1079 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220307015 | Gersbach et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles A. Gersbach (Chapel Hill, North Carolina); Joshua B. Black (Durham, North Carolina); Jennifer Kwon (Durham, North Carolina); Shaunak Adkar (Durham, North Carolina) |
| ABSTRACT | Disclosed herein are compositions, methods, and systems for selecting a polynucleotide for activity as a neuronal-specific transcription factor. The system may include a polynucleotide encoding a reporter protein and a pan-neuronal marker, a Gas protein, and a library of guide RNAs (gRNAs) targeting putative transcription factors. Further provided are methods of screening for a neuronal-specific transcription factor. |
| FILED | Wednesday, August 19, 2020 |
| APPL NO | 17/636750 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/4705 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0619 (20130101) C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/1086 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2501/60 (20130101) C12N 2506/45 (20130101) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220308047 | Cheng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Oregon State University (Corvallis, Oregon) |
| ASSIGNEE(S) | Oregon State University (Corvallis, Oregon) |
| INVENTOR(S) | Li-Jing Cheng (Corvallis, Oregon); Ye Liu (Corvallis, Oregon) |
| ABSTRACT | Disclosed probes comprise metal nanoparticle cores associated with magnetic particles that allow probes associated with targets to be concentrated by an applied magnetic field to increase detection sensitivity and provide sufficient spacing between concentrated probes to avoid signal quenching. The probe may comprise at least one recognition receptor, and may further comprise at least one reporter molecule, such as a fluorescent tag, a Raman reporter, or combinations thereof. Concentrating probe-target composites substantially enhances a sensing signal, such as from 5 to 10 times, compared to detection without concentrating the probes. The method may be used to detect, for example, interleukins at concentrations at least as low as 25 pg/ml in sputum or blood from a subject for early and precise profiling of viral infections, such as SARS-CoV-2 infections. |
| FILED | Thursday, March 17, 2022 |
| APPL NO | 17/697638 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6825 (20130101) C12Q 1/6834 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/658 (20130101) G01N 21/6428 (20130101) G01N 33/5434 (20130101) Original (OR) Class G01N 33/54333 (20130101) G01N 33/54393 (20130101) G01N 2021/6439 (20130101) G01N 2446/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220308264 | ElKabbash et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Rochester (Rochester, New York); Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mohamed ElKabbash (Cambridge, Massachusetts); Chunlei Guo (Rochester, New York); Michael Hinczewski (Beachwood, Ohio); Giuseppe Strangi (Cleveland, Ohio) |
| ABSTRACT | An optical coating includes a first resonator with a broadband light absorber. A second resonator includes a narrowband light absorber which is disposed adjacent to and optically coupled to the broadband light absorber. The phase of light reflected from the first resonator slowly varies as a function of wavelength compared to the rapid phase change of the second resonator which exhibits a phase jump within the bandwidth of the broadband light absorber. A thin film optical beam spitter filter coating is also described. |
| FILED | Thursday, March 24, 2022 |
| APPL NO | 17/703618 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 1/005 (20130101) Original (OR) Class G02B 1/11 (20130101) G02B 5/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220308447 | Stowers et al. |
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| FUNDED BY |
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| APPLICANT(S) | Inpria Corporation (Corvallis, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason K. Stowers (Corvallis, Oregon); Alan J. Telecky (Albany, Oregon); Douglas A. Keszler (Corvallis, Oregon); Andrew Grenville (Corvallis, Oregon) |
| ABSTRACT | Stabilized precursor solutions can be used to form radiation inorganic coating materials. The precursor solutions generally comprise metal suboxide cations, peroxide-based ligands and polyatomic anions. Design of the precursor solutions can be performed to achieve a high level of stability of the precursor solutions. The resulting coating materials can be designed for patterning with a selected radiation, such as ultraviolet light, x-ray radiation or electron beam radiation. The radiation patterned coating material can have a high contrast with respect to material properties, such that development of a latent image can be successful to form lines with very low line-width roughness and adjacent structures with a very small pitch. |
| FILED | Tuesday, June 14, 2022 |
| APPL NO | 17/839784 |
| CURRENT CPC | Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/20 (20130101) G03F 7/0042 (20130101) G03F 7/0043 (20130101) Original (OR) Class G03F 7/327 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/24355 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220309329 | Amiri |
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| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pedram Khalili Amiri (Chicago, Illinois) |
| ABSTRACT | A stochastic computing artificial neural network (SC-ANN) includes magnetic tunnel junction (MTJ) devices configured as true random number generators (TRNGs) to output stochastic bit-streams of random numbers for processing by input, hidden, and/or output nodes of the ANN. The processing may include multiplication by a weighting value corresponding to a respective numerical value from the stochastic bit-streams. |
| FILED | Thursday, March 24, 2022 |
| APPL NO | 17/703015 |
| CURRENT CPC | Electric Digital Data Processing G06F 7/588 (20130101) Computer Systems Based on Specific Computational Models G06N 3/063 (20130101) Original (OR) Class G06N 3/0472 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220309811 | Haghighi et al. |
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| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fatemeh Haghighi (Tempe, Arizona); Mohammad Reza Hosseinzadeh Taher (Tempe, Arizona); Zongwei Zhou (Tempe, Arizona); Jianming Liang (Scottsdale, Arizona) |
| ABSTRACT | Described herein are means for the generation of Transferable Visual Word (TransVW) models through self-supervised learning in the absence of manual labeling, in which the trained TransVW models are then utilized for the processing of medical imaging. For instance, an exemplary system is specially configured to perform self-supervised learning for an AI model in the absence of manually labeled input, by performing the following operations: receiving medical images as input; performing a self-discovery operation of anatomical patterns by building a set of the anatomical patterns from the medical images received at the system, performing a self-classification operation of the anatomical patterns; performing a self-restoration operation of the anatomical patterns within cropped and transformed 2D patches or 3D cubes derived from the medical images received at the system by recovering original anatomical patterns to learn different sets of visual representation; and providing a semantics-enriched pre-trained AI model having a trained encoder-decoder structure with skip connections in between based on the performance of the self-discovery operation, the self-classification operation, and the self-restoration operation. Other related embodiments are disclosed. |
| FILED | Saturday, February 19, 2022 |
| APPL NO | 17/676134 |
| CURRENT CPC | Image or Video Recognition or Understanding G06V 10/26 (20220101) G06V 10/82 (20220101) G06V 10/761 (20220101) G06V 10/764 (20220101) G06V 10/774 (20220101) G06V 20/70 (20220101) Original (OR) Class G06V 2201/03 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220310861 | JACKSON et al. |
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| FUNDED BY |
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| APPLICANT(S) | UbiQD, Inc. (Los Alamos, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | AARON JACKSON (Los Alamos, New Mexico); MATTHEW BERGREN (Los Alamos, New Mexico); HUNTER MCDANIEL (Los Alamos, New Mexico) |
| ABSTRACT | A laminated glass luminescent concentrator is provided which includes a solid medium having a plurality of fluorophores disposed therein. In some embodiments, the fluorophore is a low-toxicity quantum dot. In some embodiments, the fluorophore has significantly reduced self-absorption, which allows for unperturbed waveguiding of the photoluminescence over a long distance. Also disclosed are apparatuses for generating electricity from the laminated glass luminescent concentrator, and its combination with buildings and vehicles. |
| FILED | Wednesday, June 10, 2020 |
| APPL NO | 17/618346 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 20/00 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/582 (20130101) C09K 11/621 (20130101) C09K 11/0811 (20130101) Fixed or Movable Closures for Openings in Buildings, Vehicles, Fences or Like Enclosures in General, e.g Doors, Windows, Blinds, Gates E06B 9/24 (20130101) E06B 2009/2476 (20130101) Optical Elements, Systems, or Apparatus G02B 1/04 (20130101) G02B 5/206 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/055 (20130101) Original (OR) Class H01L 31/0547 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220310863 | Guo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Rochester (Rochester, New York) |
| ASSIGNEE(S) | University of Rochester (Rochester, New York) |
| INVENTOR(S) | Chunlei Guo (Rochester, New York); Anatoliy Y. Vorobyev (Saint Catharines, Canada) |
| ABSTRACT | A metal or metal alloy including a region with hierarchical micro-scale and nano-scale structure shapes, the surface region is super-hydrophobic and has a spectral reflectance of less than 30% for at least some wavelengths of electromagnetic radiation in the range of 0.1 μm to 10 μm. Methods for forming the hierarchical micro-scale and nano-scale structure shapes on the metal or metal alloy are also described. |
| FILED | Friday, May 27, 2022 |
| APPL NO | 17/826402 |
| CURRENT CPC | Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/0006 (20130101) B23K 26/082 (20151001) B23K 26/355 (20180801) B23K 26/0624 (20151001) B23K 26/3568 (20180801) B23K 2103/12 (20180801) Changing the Physical Structure of Non-ferrous Metals and Non-ferrous Alloys C22F 3/00 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/0547 (20141201) Original (OR) Class H01L 31/02327 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220311068 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Worcester Polytechnic Institute (Worcester, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yan Wang (Acton, Massachusetts); Eric Gratz (Westborough, Massachusetts); Qina Sa (Westborough, Massachusetts); Zhangfeng Zheng (Westborough, Massachusetts); Joseph Heelan (Woodstock, Connecticut); Kee-Chan Kim (Westborough, Massachusetts) |
| ABSTRACT | Cathode material from exhausted lithium ion batteries are dissolved in a solution for extracting the useful elements Co (cobalt), Ni (nickel), Al (Aluminum) and Mn (manganese) to produce active cathode materials for new batteries. The solution includes compounds of desirable materials such as cobalt, nickel, aluminum and manganese dissolved as compounds from the exhausted cathode material of spent cells. Depending on a desired proportion, or ratio, of the desired materials, raw materials are added to the solution to achieve the desired ratio of the commingled compounds for the recycled cathode material for new cells. The desired materials precipitate out of solution without extensive heating or separation of the desired materials into individual compounds or elements. The resulting active cathode material has the predetermined ratio for use in new cells, and avoids high heat typically required to separate the useful elements because the desired materials remain commingled in solution. |
| FILED | Wednesday, June 15, 2022 |
| APPL NO | 17/841152 |
| CURRENT CPC | Production and Refining of Metals; Pretreatment of Raw Materials C22B 1/24 (20130101) C22B 7/007 (20130101) C22B 23/043 (20130101) C22B 23/0423 (20130101) C22B 23/0438 (20130101) C22B 26/22 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/54 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220311358 | MAHBUB et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF NORTH TEXAS (Dallas, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ifana MAHBUB (Dallas, Texas); Russell REID (Dallas, Texas); Pashupati R. ADHIKARI (Dallas, Texas); Nishat T. TASNEEM (Dallas, Texas); Dipon K. BISWAS (Dallas, Texas) |
| ABSTRACT | A motion sensor device comprises: a reverse electrowetting-on-dielectric (REWOD) generator configured to generate alternating current (AC) based on motion; a motion sensor configured to measure motion data; and a wireless motion sensor read-out circuit coupled to the REWOD generator and the motion sensor, the wireless motion sensor read-out circuit configured to transmit the motion data and operate on the AC from the REWOD generator. |
| FILED | Thursday, March 24, 2022 |
| APPL NO | 17/703870 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0004 (20130101) A61B 5/11 (20130101) Measuring Linear or Angular Speed, Acceleration, Deceleration, or Shock; Indicating Presence, Absence, or Direction, of Movement G01P 13/00 (20130101) Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 7/06 (20130101) Electric Machines Not Otherwise Provided for H02N 1/08 (20130101) Original (OR) Class Amplifiers H03F 3/45264 (20130101) Coding; Decoding; Code Conversion in General H03M 1/46 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20220306143 | Samani et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Saeideh E. Samani (Williamsburg, Virginia); Richard K. Jessop (Hampton, Virginia); Angela R. Harrivel (Poquoson, Vatican City State); Chad L. Stephens (Poquoson, Virginia); Alan T. Pope (Poquoson, Virginia); Kellie D. Kennedy (Poquoson, Virginia) |
| ABSTRACT | A dynamic function allocation (DFA) framework balances the workload or achieves other mitigating optimizations for a human operator of a vehicle by dynamically distributing operational functional tasks between the operator and the vehicle's or robot's automation in real-time. DFA operations include those for aviation, navigation, and communication, or to meet other operational needs. The DFA framework provides an intuitive command/response interface to vehicle (e.g., aircraft), vehicle simulator, or robotic operations by implementing a Dynamic Function Allocation Control Collaboration Protocol (DFACCto). DFACCto simulates or implements autonomous control of robot's or vehicle's functional tasks and reallocates some or all tasks between a human pilot and an autonomous system when such reallocation is determined to be preferred, and implements the reallocation. The reallocation is implemented in the event of the human's distraction or incapacitation, in the event another non-nominal or non-optimal cognitive or physical state is detected, or when reallocation need is otherwise-determined. |
| FILED | Wednesday, March 02, 2022 |
| APPL NO | 17/685027 |
| CURRENT CPC | Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 40/08 (20130101) B60W 50/14 (20130101) Original (OR) Class B60W 60/001 (20200201) B60W 2040/0818 (20130101) B60W 2050/0001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220306534 | Li et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Guoqiang Li (Baton Rouge, Louisiana); Harper Meng (Baton Rouge, Louisiana) |
| ABSTRACT | A composition comprising thermoset polymer, shape memory polymer to facilitate macro scale damage closure, and a means for molecular scale healing is disclosed; the composition has the ability to resolve structural defects by a bio-mimetic close-then heal process. In use, the shape memory polymer serves to bring surfaces of a structural defect into approximation, whereafter use of the means for molecular scale healing allowed for movement of the healing means into the defect and thus obtain molecular scale healing. The means for molecular scale healing can be a thermoplastic such as fibers, particles or spheres which are used by heating to a level at or above the thermoplastic's melting point, then cooling of the composition below the melting temperature of the thermoplastic. Compositions of the invention have the ability to not only close macroscopic defects, but also to do so repeatedly even if another wound/damage occurs in a previously healed/repaired area. |
| FILED | Tuesday, May 10, 2022 |
| APPL NO | 17/740779 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 73/18 (20130101) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 20/1037 (20130101) C04B 26/04 (20130101) C04B 26/16 (20130101) Original (OR) Class C04B 26/26 (20130101) C04B 28/02 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/10 (20130101) C08G 18/664 (20130101) C08G 18/3206 (20130101) C08G 18/4238 (20130101) C08G 18/7671 (20130101) C08G 2350/00 (20130101) Compositions of Macromolecular Compounds C08L 75/04 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 6/70 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220307109 | Spradling et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Millennitek, LLC (Knoxville, Tennessee) |
| ASSIGNEE(S) | Millennitek, LLC (Knoxville, Tennessee) |
| INVENTOR(S) | Andrew M. Spradling (Knoxville, Tennessee); Lawrence W. Townsend (Knoxville, Tennessee); Kevin J. Hughes (Knoxville, Tennessee) |
| ABSTRACT | A method of forming cemented tungsten tetraboride, by combining tungsten and boron in a molar ratio of from about 1:6 to about 1:12, respectively, and firing the combined tungsten and boron in a hexagonal boron nitride crucible at a temperature of from about 1600 C to about 2000 C, to form tungsten tetraboride, milling the tungsten tetraboride to a powder, adding a metal binder to the tungsten tetraboride powder to produce a metal-tungsten tetraboride mixture, compressing the metal-tungsten tetraboride mixture, and sintering the compressed metal-tungsten tetraboride mixture to form cemented tungsten tetraboride. |
| FILED | Monday, June 06, 2022 |
| APPL NO | 17/805551 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 35/04 (20130101) Alloys C22C 1/051 (20130101) Original (OR) Class C22C 29/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220307924 | Pilant et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SPORIAN MICROSYSTEMS, INC. (Lafayette, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Evan Pilant (Longmont, Colorado); Dale Schoonover (Louisville, Colorado); Jakob Oreskovich (Boulder, Colorado); Brittany McGrogan (Denver, Colorado); Eric Schneider (Thornton, Colorado); Bradley Smith (Westminster, Colorado); William VanHoose (Aurora, Colorado) |
| ABSTRACT | A capacitive pressure transducer includes a shielded spacer positioned between the capacitor electrodes and driven with a separate voltage source. |
| FILED | Friday, March 26, 2021 |
| APPL NO | 17/213522 |
| CURRENT CPC | Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220310289 | Han et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Universities Space Research Association (Columbia, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jin-Woo Han (Mountain View, California); Meyya Meyyappan (San Jose, California); Dong-II Moon (Mountain View, California) |
| ABSTRACT | An all-printed physically unclonable function based on a single-walled carbon nanotube network. The network may be a mixture of semiconducting and metallic nanotubes randomly tangled with each other through the printing process. The unique distribution of carbon nanotubes in a network can be used for authentication, and this feature can be a secret key for a high level hardware security. The carbon nanotube network does not require any advanced purification process, alignment of nanotubes, high-resolution lithography and patterning. Rather, the intrinsic randomness of carbon nanotubes is leveraged to provide the unclonable aspect. |
| FILED | Tuesday, February 08, 2022 |
| APPL NO | 17/666716 |
| CURRENT CPC | Resistors H01C 1/14 (20130101) H01C 1/034 (20130101) H01C 7/006 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20220304273 | Shatters et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (Washington, District of Columbia); AGROSOURCE, INC. (Jupiter, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert G. Shatters (Fort Pierce, Florida); Eddie W. Stover (Fort Pierce, Florida); Randall P. Niedz (Fort Pierce, Florida); Michelle L. Heck (lthaca, New York); Marco Pitino (Port St. Lucie, Florida); Magali Ferrari Grando (Fort Pierce, Florida); Joseph Krystel (Fort Pierce, Florida) |
| ABSTRACT | The invention relates to methods and compositions for modifying a characteristic of a plant without modifying the plant's genome using one or more cells comprising one or more phytohormone genes and at least one polynucleotide of interest, which one or more phytohormone genes and the at least one polynucleotide of interest are expressed in the one or more cells. |
| FILED | Friday, September 18, 2020 |
| APPL NO | 17/635494 |
| CURRENT CPC | New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 17/00 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 9/0008 (20130101) Enzymes C12Y 102/03007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220304307 | Yang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Liu Yang (Gainesville, Florida); Gary Richoux (Gainesville, Florida); Edmund J. Norris (Gainesville, Florida); Jeffrey R. Bloomquist (Gainesville, Florida) |
| ABSTRACT | The subject matter described herein is directed to compounds, synergistic compositions, and methods for repelling arthropods. The compositions comprise acids, esters, aldehydes, or alcohols of pyrethroid-type compounds. The compounds, particularly the pyrethroid-type acids, demonstrate excellent repellency when applied both alone and in synergistic compositions. |
| FILED | Thursday, July 30, 2020 |
| APPL NO | 17/630843 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 53/00 (20130101) Original (OR) Class Acyclic or Carbocyclic Compounds C07C 69/743 (20130101) C07C 2601/02 (20170501) C07C 2601/04 (20170501) C07C 2601/08 (20170501) C07C 2601/14 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220304322 | YANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America as represented by the Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | TIANBAO YANG (ROCKVILLE, Maryland); JORGE M. FONSECA (HYATTSVILLE, Maryland) |
| ABSTRACT | The invention relates to compositions comprising at least one ABA antagonist for promoting germination/sprouting of plants or plant parts, and/or delaying fruit ripening and pigmentation; kits comprising such compositions; and methods of using such compositions to promote germination/sprouting of plants or plant parts, and/or to delay fruit ripening and pigmentation. |
| FILED | Thursday, March 24, 2022 |
| APPL NO | 17/702885 |
| CURRENT CPC | Preserving, e.g by Canning, Meat, Fish, Eggs, Fruit, Vegetables, Edible Seeds; Chemical Ripening of Fruit or Vegetables; the Preserved, Ripened, or Canned Products A23B 7/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220307095 | Salis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE PENN STATE RESEARCH FOUNDATION (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Howard Salis (University Park, Pennsylvania); Alexander Reis (University Park, Pennsylvania); Ayaan Hossain (University Park, Pennsylvania) |
| ABSTRACT | The present disclosure provides methods and systems for the massively-parallel detection of pathogens, such as SARS-CoV-2 virus, in a set of multiple samples via PCR test. Various implementations may provide for barcode/primer sequences that are designed to allow for a large number of samples and/or multiple pathogens to be analyzed in a single test. Included within the scope hereof are methods and systems for performing tests of multiple samples at once, via a one-pot test protocol, as well as methods and systems for designing test parameters (such as barcode/primer sequences) in a manner that allows for parallel testing. |
| FILED | Friday, March 18, 2022 |
| APPL NO | 17/698975 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/701 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20220310218 | Wilkinson |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Thomas Wilkinson (Avenue, Maryland) |
| ABSTRACT | Systems and methods are described, and an example system includes an AI enhanced multi-source health data integration logic that receives a first source electronic health record (EHR) data from a first EHR system and a second source EHR data from a second EHR system, and transforms, according to a knowledge representation schema, health-related information content of the first source EHR data and the second source EHR data to a first source transformed health data and second source transformed health data. The system includes a collaboration platform, configured to host a multi-source transformed health data database, including the transformed first source health data and the transformed second source health data, and hosts AI-enhanced, multiple level telecollaborative analyses by a plurality of participants of the multi-source transformed health data database, generating health management data. |
| FILED | Wednesday, March 23, 2022 |
| APPL NO | 17/701933 |
| CURRENT CPC | Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) Original (OR) Class G16H 40/67 (20180101) G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220310276 | Wilkinson |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Thomas Wilkinson (Avenue, Maryland) |
| ABSTRACT | Systems and methods are described, and an example system includes an AI enhanced multi-source health data integration logic that receives a first source electronic health record (EHR) data from a first EHR system and a second source EHR data from a second EHR system, and transforms, according to a knowledge representation schema, health-related information content of the first source EHR data and the second source EHR data to a first source transformed health data and second source transformed health data. The system includes a collaboration platform, configured to host a multi-source transformed health data database, including the transformed first source health data and the transformed second source health data, and hosts AI-enhanced, multiple level telecollaborative analyses by a plurality of participants of the multi-source transformed health data database, generating health management data. |
| FILED | Wednesday, March 23, 2022 |
| APPL NO | 17/702028 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/254 (20190101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) G16H 50/20 (20180101) G16H 80/00 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20220309626 | Levine |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zachary Howard Levine (Rockville, Maryland) |
| ABSTRACT | Removing diffraction effects in a tomographic image includes: obtaining an empirical image of a sample; producing an initial wave at a radiation source; forward propagating the initial wave from the radiation source toward a detector; receiving by a sample the initial wave; forward propagating the initial wave through the sample and accumulating phase and amplitude information to produce a phase accumulated wave; back propagating the phase accumulated wave; and forward propagating the phase accumulated wave 208 while treating Fresnel diffraction, such that the empirical image is reconstructed by projections and diffraction via maximum likelihood, a Bayesian prior probability distribution, and a Fresnel propagator. |
| FILED | Tuesday, March 22, 2022 |
| APPL NO | 17/700884 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 1/0007 (20130101) G06T 5/006 (20130101) Original (OR) Class G06T 2207/10072 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 20220307380 | Kryj-Kos et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York); General Electric Company Polska Sp. z o.o. (Warsaw, Poland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elzbieta Kryj-Kos (Liberty Township, Ohio); Piotr Jerzy Kulinski (Warsaw, Poland); Pawel Adam Lewicki (Warsaw, Poland); Ruolong Ma (Mason, Ohio); Wendy Wenling Lin (Montgomery, Ohio); Patrick Keene Clements (Cincinnati, Ohio) |
| ABSTRACT | An airfoil for a gas turbine engine defining a spanwise direction, a root end, a tip end, a leading edge end, and trailing edge end is provided. The airfoil includes: a body extending along the spanwise direction between the root end and the tip end, the body formed of a composite material; and a sculpted leading edge member attached to the body positioned at the leading edge end of the airfoil, the sculped leading edge member formed at least in part of a metal material and defining a non-linear patterned leading edge of the airfoil. |
| FILED | Friday, July 30, 2021 |
| APPL NO | 17/389945 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 9/02 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2230/31 (20130101) F05D 2240/121 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20220306992 | Lancaster et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jordan Lancaster (Tucson, Arizona); Steve Goldman (Tucson, Arizona) |
| ABSTRACT | The present invention provides methods for cellular seeding onto three-dimensional fibroblast constructs, three-dimensional fibroblast constructs seeded with muscle cells, and uses therefore. |
| FILED | Wednesday, May 18, 2022 |
| APPL NO | 17/747431 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/33 (20130101) A61K 35/34 (20130101) A61K 35/44 (20130101) A61K 45/06 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/367 (20130101) A61L 27/3604 (20130101) A61L 27/3826 (20130101) A61L 2300/64 (20130101) A61L 2430/20 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0062 (20130101) C12N 5/0657 (20130101) Original (OR) Class C12N 2502/28 (20130101) C12N 2502/1323 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
U.S. State Government
| US 20220306584 | HSIEH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Regents of the University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jer-Tsong HSIEH (Plano, Texas); Jung-Mo AHN (Plano, Texas); Zhi-Ping LIU (Dallas, Texas) |
| ABSTRACT | The present disclosure provides a new series of 8-hydroxyquinoline derivatives/analogs that are potent KDM4 inhibitors with high activity and selectivity against KDM4 enzymes. Also disclosed are the pharmaceutical compositions comprising such 8-hydroxyquinoline-based potent KDM4 inhibitors, or a pharmaceutically acceptable salt thereof, and method of use thereof, for treating cancer and neoplastic diseases and the like. |
| FILED | Saturday, June 20, 2020 |
| APPL NO | 17/596816 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 215/26 (20130101) Original (OR) Class C07D 401/12 (20130101) C07D 401/14 (20130101) C07D 405/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20220309455 | ARYEETEY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES POSTAL SERVICE (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nii-Kwashie ARYEETEY (Accokeek, Maryland); Markes LUCIUS (Arlington, Virginia); Matthew J. MAZZOLA (Washington, District of Columbia) |
| ABSTRACT | Systems, devices, and computer-implemented methods for tracking a delivery item that includes a tracking number. Embodiments can include an application on a user device, and may include operations and functions that include: extracting, from a serial barcode associated with the tracking number, a serial number and an address specifying a website associated with tracking the delivery item; automatically navigating to the website; automatically entering the serial number into the website; receiving, from the website, information indicating the location and information describing features or services associated with the delivery item based on the serial number; and displaying, on the user device, the location information and the information describing features or services associated with the delivery item. The website may provide the location information and the features/services information associated with the delivery item based on the tracking number that is attached to the deliver item and associated with the serial number. |
| FILED | Monday, June 13, 2022 |
| APPL NO | 17/838399 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 7/10722 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/0833 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20220304321 | YANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of Agriclture (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | TIANBAO YANG (ROCKVILLE, Maryland); JORGE M. FONSECA (HYATTSVILLE, Maryland) |
| ABSTRACT | The invention relates to compositions comprising at least one ABA agonist for inhibiting plant or plant part germination/sprouting, and/or promoting fruit ripening and pigmentation; kits comprising such compositions; and methods of using such compositions to inhibiting plant or plant part germination/sprouting and promoting fruit ripening and pigmentation. |
| FILED | Wednesday, March 23, 2022 |
| APPL NO | 17/702180 |
| CURRENT CPC | Preserving, e.g by Canning, Meat, Fish, Eggs, Fruit, Vegetables, Edible Seeds; Chemical Ripening of Fruit or Vegetables; the Preserved, Ripened, or Canned Products A23B 7/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220307194 | Doona et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BRANDEIS UNIVERSITY (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher J. Doona (Waltham, Massachusetts); Florence E. Feeherry (Waltham, Massachusetts); Irving R. Epstein (Waltham, Massachusetts); Kenneth Kustin (Waltham, Massachusetts) |
| ABSTRACT | An article comprising a substrate having a stimuli-responsive hydrogel polymer functionalized to or associated with a surface. The stimuli-responsive hydrogel polymer is at least partially hydrated by an aqueous disinfectant solution comprising a disinfectant. The disinfectant is formed-prior to hydrating the stimuli-responsive hydrogel polymer. At least a portion of the disinfectant is taken up, stored, or released as an aqueous solution or a gaseous vapor upon interaction with a stimulus. |
| FILED | Friday, August 28, 2020 |
| APPL NO | 17/638810 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 25/10 (20130101) A01N 59/00 (20130101) Treatment, Not Provided for Elsewhere in Class D06, of Fibres, Threads, Yarns, Fabrics, Feathers or Fibrous Goods Made From Such Materials D06M 15/285 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
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Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, September 29, 2022.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
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Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
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THE PANEL
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FUNDED BY
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Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20220929.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page