FedInvent™ Patent Applications
Application Details for Thursday, October 06, 2022
This page was updated on Thursday, October 06, 2022 at 09:26 PM GMT
Department of Health and Human Services (HHS)
| US 20220312817 | CHEN et al. |
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| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri); International Centre For Diarrhoeal Disease Research, Bangladesh (Dhaka, Bangladesh) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ROBERT YUZEN CHEN (St. Louis, Missouri); MATTHEW CHARLES HIBBERD (St. Louis, Missouri); JEFFREY l. GORDON (St. Louis, Missouri); MICHAEL J. BARRATT (St. Louis, Missouri); MD MUNIRUL ISLAM (Dhaka, Bangladesh); HAO-WEI CHANG (St. Louis, Missouri); JEANETTE GEHRIG (St. Louis, Missouri); TAHMEED AHMED (Dhaka, Bangladesh); SIDDARTH VENKATESH (St. Louis, Missouri) |
| ABSTRACT | The present disclosure provides composition and methods to improve the nutritional status of a subject, as well as aid in the maturation of the gut microbiota of a subject. The disclosure encompasses edible compositions that, when eaten in a manner described herein, impacts the subject's gut microbiota by changing the relative abundances of a plurality of health-discriminatory gut taxa in a statistically significant manner towards chronologically age-matched healthy subjects. |
| FILED | Wednesday, June 10, 2020 |
| APPL NO | 17/618314 |
| CURRENT CPC | Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 11/07 (20160801) A23L 33/15 (20160801) Original (OR) Class A23L 33/16 (20160801) A23L 33/22 (20160801) A23L 33/40 (20160801) A23L 33/115 (20160801) A23L 33/125 (20160801) A23L 33/135 (20160801) Preparations for Medical, Dental, or Toilet Purposes A61K 35/74 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220313127 | Rehan et al. |
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| FUNDED BY |
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| APPLICANT(S) | Los Angeles BioMedical Research Institute at Harbor UCLA Medical Center (Torrance, California); Intelligent Optical Systems (Torrance, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Virender Rehan (Torrance, California); Jesus Delgado (Torrance, California) |
| ABSTRACT | Embodiments described herein relate to a catheter configured to detect at least one blood gas parameter present in blood in an artery of a patient, including, but not limited to, a catheter wall forming at least one lumen configured for umbilical arterial catheterization, at least one optical fiber incorporated in the catheter wall, wherein the at least one optical fiber is configured to detected the at least one blood gas parameter. |
| FILED | Monday, June 13, 2022 |
| APPL NO | 17/839212 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/01 (20130101) A61B 5/1459 (20130101) A61B 5/6852 (20130101) A61B 5/14539 (20130101) A61B 5/14552 (20130101) A61B 5/14557 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220313144 | Rosenthal et al. |
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| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric S. Rosenthal (Boston, Massachusetts); Daniel B. Rubin (Boston, Massachusetts) |
| ABSTRACT | A system for determining a treatment outcome for a subject for a neurological disorder includes a processor, a classifier and a display. The processor is configured to receive a set of electroencephalogram (EEG) data associated with the subject and to determine at least one functional connectivity parameter based on the EEG data. The classifier is coupled to the processor and is configured to receive the at least one functional connectivity parameter and to generate a prediction for a treatment outcome based on the at least one functional connectivity parameter. The display is coupled to the classifier and is configured to display the prediction for the treatment outcome. |
| FILED | Monday, September 14, 2020 |
| APPL NO | 17/642167 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/369 (20210101) A61B 5/742 (20130101) A61B 5/4076 (20130101) Original (OR) Class A61B 5/7267 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220313599 | VEISEH et al. |
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| FUNDED BY |
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| APPLICANT(S) | William Marsh Rice University (Houston, Texas) |
| ASSIGNEE(S) | William Marsh Rice University (Houston, Texas) |
| INVENTOR(S) | Omid VEISEH (Houston, Texas); Amanda NASH (Houston, Texas); Maria Isabel JARVIS-RUOCCO (Houston, Texas); Sudip MUKHERJEE (Houston, Texas); Michael David DOERFERT (Houston, Texas); Samira AGHLARA-FOTOVAT (Houston, Texas); David Yu ZHANG (Houston, Texas) |
| ABSTRACT | The present disclosure relates to implantable constructs designed to deliver antigenic therapeutic reagents to a subject while providing protection from host immune responses. In certain aspects, the constructs are designed to degrade over time or upon a particular signal, thereby providing control of the length of time the therapeutic agent is delivered to the subject. |
| FILED | Friday, August 07, 2020 |
| APPL NO | 17/633716 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0024 (20130101) Original (OR) Class A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220313617 | NAIR et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (MIAMI, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | MADHAVAN NAIR (CORAL GABLES, Florida); ANDREA RAYMOND (MIRAMAR, Florida); ARTI VASHIST (MIAMI, Florida) |
| ABSTRACT | A method of treatment or prevention of HIV and other viral infection comprising the administration of a biopolymer-based hydrogel nanoparticles and/or microparticles. In preferred embodiments, the particles comprise chitosan, hydroxyethyl cellulose (HEC), and linseed oil polyol. These biopolymer-based hydrogel nanoparticles and/or microparticles are antiviral agents that can be employed alone or in combination with other drugs for treatment of the viral infection. Further, the pre-treatment with the particles is highly effective at inhibiting viruses. Therefore, this antiviral biopolymer-based hydrogel nanoparticles and/or microparticles may also be employed as a prophylactic. |
| FILED | Friday, June 05, 2020 |
| APPL NO | 17/615940 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1075 (20130101) A61K 9/2081 (20130101) A61K 9/5146 (20130101) A61K 9/5161 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220313624 | DONG et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California) |
| ASSIGNEE(S) | THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California) |
| INVENTOR(S) | Jiajia DONG (Shanghai city, China PRC); K. Barry SHARPLESS (La Jolla, California); Jeffery W. KELLY (La Jolla, California); Aleksandra BARANCZAK (Gurnee, Illinois); Wentao CHEN (Walnut Creek, California) |
| ABSTRACT | Described herein are compounds comprising a biologically active organic core group with one to five —Z—(X1—S(O)(X2)F)m groups attached thereto, wherein Z is O, NR, or N; X1 is a covalent bond or CH2CH2; m can be 1 or 2 depending on the identity of Z; and X2 is O or NR. In some embodiments, the core group is an amino acid or a protein. In some embodiments the core group is a compound that has therapeutic activity toward a therapeutic target. |
| FILED | Friday, May 27, 2022 |
| APPL NO | 17/826660 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/05 (20130101) Original (OR) Class A61K 31/14 (20130101) A61K 31/40 (20130101) A61K 31/47 (20130101) A61K 31/53 (20130101) A61K 31/56 (20130101) A61K 31/65 (20130101) A61K 31/70 (20130101) A61K 31/136 (20130101) A61K 31/197 (20130101) A61K 31/198 (20130101) A61K 31/397 (20130101) A61K 31/407 (20130101) A61K 31/439 (20130101) A61K 31/473 (20130101) A61K 31/485 (20130101) A61K 31/505 (20130101) A61K 31/515 (20130101) A61K 31/655 (20130101) A61K 31/4045 (20130101) A61K 31/4168 (20130101) A61K 31/4245 (20130101) A61K 31/4353 (20130101) A61K 31/4709 (20130101) A61K 31/4745 (20130101) A61K 31/5513 (20130101) A61K 31/7048 (20130101) A61K 38/31 (20130101) A61K 47/54 (20170801) A61K 51/0497 (20130101) Acyclic or Carbocyclic Compounds C07C 305/26 (20130101) C07C 2601/14 (20170501) C07C 2603/18 (20170501) Heterocyclic Compounds C07D 277/82 (20130101) C07D 279/08 (20130101) C07D 295/26 (20130101) C07D 295/088 (20130101) C07D 295/185 (20130101) C07D 501/18 (20130101) Peptides C07K 1/02 (20130101) C07K 1/1136 (20130101) C07K 2/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220313636 | Osborn et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Olivia Osborn (Cardiff, California); Rizaldy Zapata (La Jolla, California) |
| ABSTRACT | Compositions and methods of use for modulating weight gain in a subject. Methods for treating obesity in a subject comprising administering to a subject in need an effective amount of a chloride intracellular channel protein 1 (Clic1) inhibitor, such as indanyloxyacetic acid 94 (IAA94). |
| FILED | Wednesday, May 06, 2020 |
| APPL NO | 17/608837 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/47 (20130101) A61K 31/57 (20130101) A61K 31/155 (20130101) A61K 31/192 (20130101) Original (OR) Class A61K 31/365 (20130101) A61K 31/704 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220313650 | Garcia et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Mario Arias Garcia (Cambridge, Massachusetts); Guoping Fong (Cambridge, Massachusetts); Zhanyan Fu (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein are methods for treating a neurodevelopmental disorder using a group II metabotropic glutamate receptor modulator. |
| FILED | Friday, May 01, 2020 |
| APPL NO | 17/608089 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/34 (20130101) Original (OR) Class A61K 31/496 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/16 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/09 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220313658 | Mascharak et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shamik Mascharak (Palo Alto, California); Heather Elizabeth DesJardins-Park (Stanford, California); Mimi Borrelli (Stanford, California); Michael Francis Davitt (Stanford, California); Michael T. Longaker (Stanford, California) |
| ABSTRACT | Methods of promoting healing of a wound in a dermal location of a subject are provided. Aspects of the methods may include administering an effective amount of a YAP inhibitor composition to the wound to modulate mechanical activation of Engrailed-1 lineage-negative fibroblasts (ENFs) in the wound to promote ENF-mediated healing of the wound. Also provided are methods of preventing scarring during healing of a wound in a subject and methods of promoting hair growth on a subject. Aspects of the methods may include forming a wound in a dermal location of a subject and administering an effective amount of a YAP inhibitor composition to the wound to modulate mechanical activation of Engrailed-1 lineage-negative fibroblasts (ENFs) in the wound to promote ENF-mediated healing of the wound. Also provided are kits including an amount of a YAP inhibitor composition and a tissue disrupting device. |
| FILED | Friday, July 24, 2020 |
| APPL NO | 17/626699 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/409 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/02 (20180101) A61P 17/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220313665 | Gavathiotis et al. |
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| FUNDED BY |
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| APPLICANT(S) | Albert Einstein College of Medicine (Bronx, New York) |
| ASSIGNEE(S) | Albert Einstein College of Medicine (Bronx, New York) |
| INVENTOR(S) | Evripidis Gavathiotis (Roslyn, New York); Denis E. Reyna (Bronx, New York); Felix Kopp (Brooklyn, New York); Ulrich Steidl (New Rochelle, New York) |
| ABSTRACT | Activators of BAX and their uses in cancer therapy are disclosed. |
| FILED | Tuesday, June 07, 2022 |
| APPL NO | 17/834087 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/427 (20130101) Original (OR) Class A61K 31/429 (20130101) A61K 31/437 (20130101) A61K 31/4439 (20130101) A61K 31/5377 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220313666 | Natarajan et al. |
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| FUNDED BY |
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| APPLICANT(S) | City of Hope (Duarte, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rama Natarajan (Hacienda Heights, California); Feng Miao (Alhambra, California); Nagarajan Vaidehi (Arcadia, California); Supriyo Bhattacharya (Monrovia, California); Adrien Beau Larsen (Duarte, California) |
| ABSTRACT | Disclosed herein, inter alia, are compounds and methods for inhibiting the thioredoxin-thioredoxin-interacting-protein (TXNIP-TRX) complex. |
| FILED | Wednesday, April 06, 2022 |
| APPL NO | 17/714569 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/437 (20130101) Original (OR) Class A61K 31/496 (20130101) A61K 31/4035 (20130101) A61K 31/4439 (20130101) A61K 31/5377 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220313680 | Calakos et al. |
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| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina); The United States of America, as Represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicole Calakos (Durham, North Carolina); Zachary F. Caffall (Durham, North Carolina); Joseph Rittiner (Durham, North Carolina); Min Shen (Bethesda, Maryland); Jennifer T. Fox (Bethesda, Maryland); Zhuyin Li (Bethesda, Maryland) |
| ABSTRACT | The present disclosure provides methods and compositions for the treatment, identification, diagnosis, and prognosis of dystonia, or dystonia related disorders. |
| FILED | Monday, March 28, 2022 |
| APPL NO | 17/706461 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/17 (20130101) A61K 31/47 (20130101) Original (OR) Class A61K 31/427 (20130101) A61K 31/472 (20130101) A61K 31/497 (20130101) A61K 31/513 (20130101) A61K 31/4706 (20130101) A61K 31/4725 (20130101) A61K 38/05 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/14 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) C12Q 1/6883 (20130101) C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) G01N 2800/52 (20130101) G01N 2800/2835 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220313687 | Li et al. |
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| FUNDED BY |
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| APPLICANT(S) | Clear Scientific, Inc. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xinhua Li (Newton, Massachusetts); Mitchell Zakin (Andover, Massachusetts); Chandrashekar Shetty (Brookline, Massachusetts); Piercen Oliver (Malden, Massachusetts); Daniel Wallach (Melrose, Massachusetts) |
| ABSTRACT | Described herein are i) sequestering agents and ii) central nervous system (CNS) active agents for the treatment of intoxication due to toxic agents such as drugs of abuse, and associated symptoms. Also disclosed herein, are a cucurbituril and naloxone for use in the treatment of opioid overdoses through sequestering and excretion of the bound molecule of interest through the urine. Also provided herein, are kits and methods of treatment of the disclosure. |
| FILED | Thursday, February 10, 2022 |
| APPL NO | 17/669122 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/485 (20130101) Original (OR) Class A61K 31/551 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/36 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220313717 | MANNINO et al. |
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| FUNDED BY |
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| APPLICANT(S) | MATINAS BIOPHARMA NANOTECHNOLOGIES, INC. (Bedminster, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Raphael J. MANNINO (Glen Gardner, New Jersey); Ruying LU (New Providence, New Jersey); Theresa MATKOVITS (West Orange, New Jersey) |
| ABSTRACT | The present disclosure is directed to a method of treating or preventing a fungal infection in a subject including a Cryptococcus spp., which method includes an induction treatment phase and a consolidation treatment phase, wherein the induction treatment phase includes: administering amphotericin B (cAMB) and 5-Flucytosine or an azole to the subject, wherein the cAMB and the 5-Flucytosine or the azole are mucosally administered. cAMB formulations are also disclosed. |
| FILED | Thursday, August 13, 2020 |
| APPL NO | 17/629048 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/006 (20130101) A61K 9/1274 (20130101) A61K 31/513 (20130101) A61K 31/4196 (20130101) A61K 31/7048 (20130101) Original (OR) Class A61K 47/02 (20130101) A61K 47/14 (20130101) A61K 47/22 (20130101) A61K 47/24 (20130101) A61K 47/38 (20130101) A61K 47/183 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220313720 | Lobb et al. |
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| FUNDED BY |
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| APPLICANT(S) | The United States of America, as Represented by the Secretary, Department of Health and Human Serv (Bethesda, Maryland); Aleta Biotherapeutics Inc. (Natick, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Roy Lobb (Wellesley, Massachusetts); Paul Rennert (Holliston, Massachusetts); John Todd Schiller (Kensington, Maryland) |
| ABSTRACT | Some embodiments of the present disclosure are directed to methods that include delivering to a subject a nucleic acid encoding an antigen, wherein the nucleic acid is delivered via a tumor-selective vehicle or via intratumoral injection, and delivering to the subject an immune cell expressing a receptor that binds to the antigen. |
| FILED | Wednesday, November 17, 2021 |
| APPL NO | 17/528827 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/7088 (20130101) Original (OR) Class A61K 35/761 (20130101) A61K 35/763 (20130101) A61K 35/765 (20130101) A61K 35/766 (20130101) A61K 35/768 (20130101) A61K 39/0011 (20130101) A61K 39/00115 (20180801) A61K 39/00116 (20180801) A61K 39/00117 (20180801) A61K 39/001104 (20180801) A61K 39/001106 (20180801) A61K 39/001109 (20180801) A61K 39/001112 (20180801) A61K 39/001113 (20180801) A61K 39/001119 (20180801) A61K 39/001122 (20180801) A61K 39/001124 (20180801) A61K 39/001166 (20180801) A61K 39/001168 (20180801) A61K 39/001171 (20180801) A61K 39/001174 (20180801) A61K 39/001182 (20180801) A61K 39/001186 (20180801) A61K 39/001188 (20180801) A61K 39/001191 (20180801) A61K 39/001192 (20180801) A61K 39/001195 (20180801) A61K 2039/5152 (20130101) A61K 2039/5156 (20130101) A61K 2039/5158 (20130101) Peptides C07K 14/70503 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220313735 | Pelus et al. |
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| FUNDED BY |
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| APPLICANT(S) | Indiana University Research and Technology Corporation (Indianapolis, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Louis M. Pelus (Indianapolis, Indiana); Jonathan Hoggatt (Somerville, Massachusetts); Pratibha Singh (Indianapolis, Indiana) |
| ABSTRACT | This disclosure is directed to the methods of enhancing hematopoietic stem cells (HSPC) and progenitor cell (HSPC) engraftment procedure. Treatment in vivo of a HSPC donor with compounds that reduce PGE2 biosynthesis or PGE2 receptor antagonists alone, or in combination with other hematopoietic mobilization agents such as AMD3100 and G-CSF, increases the circulation of available HSPCs. Compounds that reduce the cellular synthesis of PGE2 include non−steroidal anti-inflammatory compounds such as indomethacin. Treatment ex vivo of HSPC with an effective amount of PGE2 or at least one of its derivatives such as 16,16-dimethyl prostaglandin E2 (dmPGE2), promotes HSPC engraftment. Similar methods may also be used to increase viral-mediated gene transduction efficacy into HSPC. |
| FILED | Tuesday, December 14, 2021 |
| APPL NO | 17/550737 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/00 (20130101) A61K 31/395 (20130101) A61K 31/405 (20130101) A61K 31/4035 (20130101) A61K 31/4196 (20130101) A61K 31/5415 (20130101) A61K 35/14 (20130101) Original (OR) Class A61K 35/28 (20130101) A61K 35/50 (20130101) A61K 35/51 (20130101) A61K 38/193 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/16 (20130101) C12N 5/0647 (20130101) C12N 9/0083 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220313775 | Twiss et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of South Carolina (Columbia, South Carolina) |
| ASSIGNEE(S) | University of South Carolina (Columbia, South Carolina) |
| INVENTOR(S) | Jeffery L. Twiss (Columbia, South Carolina); Pabitra Sahoo (West Columbia, South Carolina) |
| ABSTRACT | Methods for using a peptide to effectively increase axon growth in both naive and injury-conditioned neurons. |
| FILED | Tuesday, June 14, 2022 |
| APPL NO | 17/839820 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220313777 | Yates et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); Tuskegee University (Tuskegee, Alabama) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); Tuskegee University (Tuskegee, Alabama) |
| INVENTOR(S) | Cecelia C. Yates (Pittsburgh, Pennsylvania); Timothy E. Corcoran (Pittsburgh, Pennsylvania); Zariel I. Johnson (Pittsburgh, Pennsylvania); Jesse Jaynes (Tuskegee, Alabama) |
| ABSTRACT | Administration via inhalation of small peptides that mimic CXCL10 (FIBROKINE™ peptides) is described. The peptides can be administered as an aerosol, such as an aerosol with a droplet size small enough to reach lung alveoli. Use of the peptides to treat fibrosis, such as lung fibrosis, is described. |
| FILED | Thursday, September 10, 2020 |
| APPL NO | 17/641955 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0075 (20130101) A61K 9/0078 (20130101) A61K 38/10 (20130101) A61K 38/16 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) Peptides C07K 14/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220313780 | Healy et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Laura D. Healy (San Diego, California); Laurent O. Mosnier (San Diego, California); John H. Griffin (Del Mar, California) |
| ABSTRACT | The present invention provides novel compositions for suppressing inflammation and for treating inflammatory disorders. These compositions contain at least one PARS-derived anti-inflammatory peptide or polypeptide and/or at least one PARI-derived anti-inflammatory peptide or polypeptide. The PARS- and/or PARI-derived peptides typically contain an amino acid sequence that mimics the respective N-terminal sequence of Activated Protein C-cleaved PARS or PARI, e.g., after activated protein C cleavage at residue Arg41 in human PARS and after residue Arg46 in human PARI. The invention also provides therapeutic methods of using the anti-inflammatory compositions described herein to suppress undesired inflammation and to treat inflammatory disorders. Additionally provided in the invention are methods of screening candidate compounds to identity novel anti-inflammatory agents. |
| FILED | Wednesday, June 17, 2020 |
| APPL NO | 17/617989 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) A61K 9/0024 (20130101) A61K 38/177 (20130101) Original (OR) Class A61K 47/10 (20130101) A61K 47/6801 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220313781 | Seminara et al. |
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| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts); Children`s Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephanie Beth Seminara (West Newton, Massachusetts); Yee-Ming Chan (Canton, Massachusetts); Margaret Flynn Lippincott (Somerville, Massachusetts) |
| ABSTRACT | Methods of diagnosing and treating pathologic hypogonadotropic hypogonadism and reproductive endocrine dysfunction using kisspeptin and kisspeptin analogs. |
| FILED | Monday, June 08, 2020 |
| APPL NO | 17/616144 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/485 (20130101) A61K 38/1709 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 5/02 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/74 (20130101) G01N 2333/59 (20130101) G01N 2800/048 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220313785 | Chavez et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Xalud Therapeutics, Inc. (Berkeley, California); The Regents of the University of Colorado, a Body Corporate (Denver, Colorado) |
| ASSIGNEE(S) | Xalud Therapeutics, Inc. (Berkeley, California); The Regents of the University of Colorado, a Body Corporate (Denver, Colorado) |
| INVENTOR(S) | Raymond A. Chavez (Alameda, California); Linda May Rothblum Watkins (Boulder, Colorado); Robert Landry (Erie, Colorado) |
| ABSTRACT | This invention provides compositions and methods for preventing inflammatory diseases of the joints, including rheumatoid and osteoarthritis, tendonitis, bursitis, inflammation of the ligament, synovitis, gout, and systemic lupus erythematosus, wherein the methods include injecting into the inflamed joint a therapeutic anti-inflammatory composition comprising a bacterial or viral IL-10 expression construct, wherein the IL-10 expression construct comprises a bacterial or viral backbone and a nucleic acid sequence encoding interleukin-10. |
| FILED | Tuesday, June 21, 2022 |
| APPL NO | 17/845101 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/2066 (20130101) Original (OR) Class A61K 48/005 (20130101) A61K 48/0075 (20130101) A61K 48/0091 (20130101) Peptides C07K 14/5428 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220313792 | HICKEY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard HICKEY (Columbus, Ohio); Andre PALMER (Columbus, Ohio) |
| ABSTRACT | Disclosed herein are oxygen transporting formulations, in particular those composed of hemoglobin-based nanoparticles, and their use and process of manufacture. These formulations are more uniform and monodisperse than prior hemoglobin-based oxygen carriers, such as polymeric hemoglobin. In addition, these formulations provide higher hemoglobin encapsulation efficiencies and higher hemoglobin content that hemoglobin-containing vesicles. |
| FILED | Friday, August 28, 2020 |
| APPL NO | 17/638600 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/14 (20130101) A61K 9/0019 (20130101) A61K 38/42 (20130101) Original (OR) Class A61K 38/385 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220313795 | Khalili et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Temple University of The Commonwealth System of Higher Education (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kamel Khalili (Bala Cynwyd, Pennsylvania); Wenhui Hu (Cherry Hill, New Jersey) |
| ABSTRACT | A method of preventing transmission of a retrovirus from a mother to her offspring, by administering to the mother a therapeutically effective amount of a composition comprising a Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated endonuclease, and the two or more different multiplex gRNAs, wherein each of the at least two gRNAs is complementary to a different target nucleic acid sequence in a long terminal repeat (LTR) of proviral DNA of the virus that is unique from the genome of the host cell, cleaving a double strand of the proviral DNA at a first target protospacer sequence with the CRISPR-associated endonuclease, cleaving a double strand of the proviral DNA at a second target protospacer sequence with the CRISPR-associated endonuclease, excising an entire HIV-1 proviral genome, eradicating the HIV-1 proviral DNA from the host cell, and preventing transmission of the proviral DNA to the offspring. |
| FILED | Monday, May 24, 2021 |
| APPL NO | 17/329137 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0034 (20130101) A61K 35/12 (20130101) A61K 38/465 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 48/00 (20130101) A61K 48/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 9/22 (20130101) C12N 15/111 (20130101) C12N 2310/20 (20170501) C12N 2320/30 (20130101) C12N 2740/16063 (20130101) Enzymes C12Y 301/21 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220313800 | SCHUCHMAN |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edward H. SCHUCHMAN (Haworth, New Jersey) |
| ABSTRACT | Proteins, compositions, and methods for treating Farber disease are provided. |
| FILED | Tuesday, May 31, 2022 |
| APPL NO | 17/828131 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/50 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/52 (20130101) C12N 15/86 (20130101) Enzymes C12Y 305/01023 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220313801 | Schlom et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Jeffrey Schlom (Potomac, Maryland); Claudia M. Palena (Potomac, Maryland) |
| ABSTRACT | Brachyury protein can be used to induce Brachyury-specific CD4+ T cells in vivo and ex vivo. It is also disclosed that Brachyury protein can be used to stimulate the production of both Brachyury-specific CD4+ T cells and Brachyury-specific CD8+ T cells in a subject, such as a subject with cancer. In some embodiments, the methods include the administration of a Brachyury protein. In additional embodiments, the methods include the administration of a nucleic acid encoding the Brachyury protein, such as in a non-pox non-yeast vector. In further embodiments, the methods include the administration of host cells expressing the Brachyury protein. |
| FILED | Monday, June 06, 2022 |
| APPL NO | 17/833383 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0005 (20130101) Original (OR) Class A61K 39/0011 (20130101) A61K 39/39 (20130101) A61K 39/39558 (20130101) A61K 45/06 (20130101) A61K 2039/55583 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/10 (20130101) Peptides C07K 14/82 (20130101) C07K 14/4702 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2710/16234 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57415 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220313802 | GONI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NEW YORK UNIVERSITY (New York, New York); INSTITUTO NACIONAL DE TECNOLOGIA AGROPECUARIA (INTA) (Buenos Aires, Argentina); UNIVERSIDAD DE LA REPUBLICA (Montevideo, Uruguay) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fernando GONI (New York, New York); Thomas WISNIEWSKI (Staten Island, New York); Lucia YIM (Montevideo, Uruguay); Jose Alejandro CHABALGOITY (Montevideo, Uruguay); Analia ELISEI (Buenos Aires, Argentina) |
| ABSTRACT | The present disclosure is directed to a multi-species prion protein or peptide thereof, and vaccine compositions comprising the same that are useful for the vaccination and treatment of mammalian subjects at risk of having or having prion disease. Also disclosed herein are isolated proteins and peptides, polymers, vaccines, animal bait or feed, antibodies, and methods of inhibiting the onset of or treating a prion disease. |
| FILED | Monday, May 11, 2020 |
| APPL NO | 17/610388 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0007 (20130101) Original (OR) Class A61K 2039/522 (20130101) A61K 2039/523 (20130101) A61K 2039/6037 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Peptides C07K 14/47 (20130101) C07K 16/2872 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220313809 | Ballard et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of the University of Oklahoma (Norman, Oklahoma) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jimmy D. Ballard (Norman, Oklahoma); Sarah J. Bland (Oklahoma City, Oklahoma) |
| ABSTRACT | An immunogenic composition comprising a deletion mutant of a Clostridioides difficile TcdB toxin (such as TcdB2 or TcdB1) that lacks residues at least from amino acid residue 1769 to amino acid residue 1787 of a wild-type TcdB amino acid sequence or of a protein having high identity thereto, a vaccine comprising the immunogenic composition, a method of stimulating an immune response, a nucleic acid which encodes the amino acid sequence of the deletion mutant, a vector encoding the nucleic acid, and a host cell comprising the vector. |
| FILED | Friday, May 08, 2020 |
| APPL NO | 17/608843 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/08 (20130101) Original (OR) Class A61K 47/02 (20130101) A61K 2039/52 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) C12N 15/102 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220313993 | Gerasimenko et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Yury P. Gerasimenko (Los Angeles, California); Victor Reggie Edgerton (Los Angeles, California); Roland R. Roy (Playa Vista, California); Daniel C. Lu (Los Angeles, California) |
| ABSTRACT | In various embodiments, non-invasive methods to induce motor control in a mammal subject to spinal cord or other neurological injuries are provided. In some embodiments the methods involve administering transcutaneous electrical spinal cord stimulation (tSCS) to the mammal at a frequency and intensity that induces locomotor activity. |
| FILED | Friday, June 10, 2022 |
| APPL NO | 17/837913 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/00 (20130101) A61K 31/197 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0456 (20130101) A61N 1/36003 (20130101) Original (OR) Class A61N 1/36034 (20170801) Apparatus for Physical Training, Gymnastics, Swimming, Climbing, or Fencing; Ball Games; Training Equipment A63B 2213/004 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220314010 | Halperin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Henry Halperin (Baltimore, Maryland); Ehud J. Schmidt (Boston, Massachusetts); Ronald D. Watkins (Stanford, California); Harikrishna Tandri (Ellicott City, Maryland); David Hunter (Baltimore, Maryland); Leslie Tung (Columbia, Maryland); Ronald D. Berger (Baltimore, Maryland) |
| ABSTRACT | A magnetic-resonance-imaging-compatible (MRI-compatible) cardiac defibrillator includes: a defibrillator generator; first and second electric wires, each being electrically connected to said defibrillator generator; first and second defibrillation pads, each being electrically connected to a respective one of said first and second electric wires; and a low pass filter electrically connected between said defibrillator generator and said first and second electric wires to prevent a noise in an MRI image caused by a radiofrequency interference from the defibrillator as well as protect a patient and the defibrillator from MRI radiofrequency imaging signals, wherein said low pass filter has a cutoff frequency set such that differential mode noise at an MRI Larmor frequency is in an attenuated band while a system-test signal by said defibrillator generator is in a pass band of said low pass filter. |
| FILED | Monday, November 15, 2021 |
| APPL NO | 17/526254 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/361 (20210101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/3904 (20170801) Original (OR) Class A61N 1/3925 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220314183 | YEE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Daryl Wei Liang YEE (Pasadena, California); Julia R. GREER (Pasadena, California); Max L. LIFSON (Pasadena, California); Michael A. CITRIN (Pasadena, California) |
| ABSTRACT | In an aspect, a method for making a metal-containing material comprises steps of: forming a metal-containing hydrogel from an aqueous precursor mixture using a photopolymerization; wherein the aqueous precursor mixture comprises water, one or more aqueous photosensitive binders, and one or more aqueous metal salts; and thermally treating the metal-containing hydrogel to form the metal-containing material; wherein the metal-containing hydrogel is exposed to a thermal-treatment atmosphere during the step of thermally treating; wherein a composition of the metal-containing material is at least partially determined by a composition of the thermal-treatment atmosphere during the thermally treating step. |
| FILED | Thursday, March 31, 2022 |
| APPL NO | 17/710456 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 6/001 (20130101) B01J 13/0056 (20130101) Original (OR) Class B01J 13/0069 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 65/002 (20130101) C08G 2210/00 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/28 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/032 (20130101) G03F 7/0037 (20130101) G03F 7/0047 (20130101) G03F 7/70375 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/48 (20130101) H01M 4/133 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220315528 | Gouw et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arvin Gouw (San Francisco, California); Steven R. Schow (Redwood City, California); Robert J. Greenhouse (Newark, California); Toni Kline (San Francisco, California); Dean W. Felsher (San Mateo, California) |
| ABSTRACT | Inhibitors of Glycerol 3-Phosphate Acyltransferase (GPAT) are provided; and methods of use in the treatment of cancer; and treatment of conditions relating to metabolic syndrome, hyperlipidemia, infection and inflammation. |
| FILED | Thursday, August 20, 2020 |
| APPL NO | 17/635891 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/00 (20180101) Acyclic or Carbocyclic Compounds C07C 311/08 (20130101) Original (OR) Class C07C 311/14 (20130101) C07C 311/51 (20130101) Heterocyclic Compounds C07D 213/79 (20130101) C07D 401/04 (20130101) C07D 493/04 (20130101) C07D 493/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220315529 | Xu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qiaobing Xu (Lexington, Massachusetts); Yamin Li (Somerville, Massachusetts) |
| ABSTRACT | Disclosed are noncationic lipidoid nanoparticles (LNPs) for His-tagged protein delivery. |
| FILED | Friday, July 31, 2020 |
| APPL NO | 17/631769 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5123 (20130101) A61K 9/5146 (20130101) A61K 45/06 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Acyclic or Carbocyclic Compounds C07C 229/26 (20130101) C07C 321/18 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220315548 | Xu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan); National Center for Advancing Translational Sciences (Rockville, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Haoxing Xu (Ann Arbor, Michigan); Lu Yu (Ann Arbor, Michigan); Juan Jose Marugan (Gaithersburg, Maryland); Raul Rolando Calvo (Germantown, Maryland); Natalia Julia Martinez (Rockville, Maryland); Noel Terrence Southall (Potomac, Maryland); Marc Ferrer (Potomac, Maryland); Xin Hu (Frederick, Maryland) |
| ABSTRACT | This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a phenyl-sulfonic amide (or similar) structure which function as agonists of mucolipin 1 (ML1), and their use as therapeutics for the treatment of Duchenne muscular dystrophy (DMD) and related disorders. |
| FILED | Friday, August 28, 2020 |
| APPL NO | 17/638929 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/06 (20180101) Acyclic or Carbocyclic Compounds C07C 311/21 (20130101) C07C 2601/14 (20170501) Heterocyclic Compounds C07D 207/09 (20130101) C07D 207/323 (20130101) C07D 211/26 (20130101) C07D 223/04 (20130101) C07D 235/08 (20130101) C07D 291/08 (20130101) Original (OR) Class C07D 295/135 (20130101) C07D 401/04 (20130101) C07D 401/12 (20130101) C07D 471/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220315553 | Piazza et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ADT Pharmaceuticals, LLC (Orange Beach, Alabama) |
| ASSIGNEE(S) | ADT Pharmaceuticals, LLC (Orange Beach, Alabama) |
| INVENTOR(S) | Gary A. Piazza (Daphne, Alabama); Xi Chen (Hoover, Alabama); Adam B. Keeton (Gardendale, Alabama); Michael R. Boyd (Orange Beach, Alabama) |
| ABSTRACT | Disclosed are compounds, for example, compounds of formula I, wherein R, R0, R1-R8, n, X, Y, Y′, and E are as described herein, pharmaceutical compositions containing such compounds, and methods of treating or preventing a disease or condition, for example, cancer. |
| FILED | Wednesday, June 08, 2022 |
| APPL NO | 17/835551 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/36 (20130101) A61K 31/40 (20130101) A61K 31/44 (20130101) A61K 31/341 (20130101) A61K 31/401 (20130101) A61K 31/445 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) Acyclic or Carbocyclic Compounds C07C 233/58 (20130101) C07C 235/32 (20130101) C07C 237/20 (20130101) C07C 2601/02 (20170501) C07C 2602/08 (20170501) Heterocyclic Compounds C07D 207/14 (20130101) C07D 207/337 (20130101) C07D 211/56 (20130101) C07D 213/24 (20130101) C07D 213/75 (20130101) C07D 235/30 (20130101) C07D 307/38 (20130101) C07D 307/52 (20130101) C07D 307/54 (20130101) C07D 317/64 (20130101) Original (OR) Class C07D 405/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220315574 | Lefkowitz et al. |
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| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Lefkowitz (Durham, North Carolina); Alem KAHSAI (Durham, North Carolina) |
| ABSTRACT | The present disclosure provides novel β-arrestin-modulating compounds and methods of making and using same. |
| FILED | Friday, July 31, 2020 |
| APPL NO | 17/630667 |
| CURRENT CPC | Heterocyclic Compounds C07D 217/20 (20130101) C07D 307/80 (20130101) C07D 417/12 (20130101) Original (OR) Class C07D 493/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220315624 | Ellman et al. |
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| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan Ellman (Guilford, Connecticut); Ryan Scamp (New Haven, Connecticut); Scott Miller (Woodbridge, Connecticut); Edward de Ramon (New Haven, Connecticut) |
| ABSTRACT | Provided herein are thiostrepton analogues, such as but not limited to compounds of Formula I, with improved aqueous solubility and antibacterial properties against antibiotic-resistant bacterial strains. The methods of the disclosure further provide a chemoselective way to introduce diverse functionality into peptides or protein comprising a dehydroalanine residue. |
| FILED | Wednesday, May 13, 2020 |
| APPL NO | 17/610778 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 5/101 (20130101) C07K 5/0806 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220315629 | O'Keefe et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland); University of Louisville Research Foundation, Inc. (Louisville, Kentucky); University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland); University of Louisville Research Foundation, Inc. (Louisville, Kentucky); University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Barry R. O'Keefe (Frederick, Maryland); Tinoush Moulaei (College Park, Maryland); Kenneth E. Palmer (Owensboro, Kentucky); Lisa C. Rohan (Pittsburgh, Pennsylvania); Joshua L. Fuqua (Owensboro, Kentucky); Lindsay F. Kramzer (Pittsburgh, Pennsylvania) |
| ABSTRACT | The invention provides modified griffithsin polypeptides comprising the amino acid sequence of SEQ ID NO: 1, as well as corresponding nucleic acids, vectors, cells, fusion proteins, constructs, conjugates, and methods of inhibiting viral infection. |
| FILED | Tuesday, April 19, 2022 |
| APPL NO | 17/724342 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/16 (20130101) Peptides C07K 14/405 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220315631 | PEI |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dehua PEI (Columbus, Ohio) |
| ABSTRACT | The present disclosure provides novel polypeptide conjugates. The polypeptide conjugates disclosed herein comprise a stapled peptidyl beta-catenin ligand and at least one staple which holds the peptidyl ligand in an α-helical confirmation, and a cell-penetrating peptide (CPP) conjugated, directly or indirectly, to the stapled peptide. |
| FILED | Friday, August 28, 2020 |
| APPL NO | 17/639014 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/645 (20170801) Peptides C07K 14/4702 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220315645 | WANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Rockefeller University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qiao WANG (New York, New York); Michel NUSSENZWEIG (New York, New York) |
| ABSTRACT | Provided are broadly neutralizing antibodies (bNAbs) and antigen binding fragments thereof that bind with specificity to epitopes expressed by Hepatitis B vims (HBV). The bNAbs target non-overlapping epitopes on the HBV S antigen (HBsAg). Pharmaceutical compositions that contain the bNAbs, or modified bNAbs, are provided. Combinations of the bNAbs are included, and are useful for prophylaxis and therapy of HBV infection, and for inhibiting development of HBV escape mutations in infected individuals. Expression vectors encoding the bNAbs and antigenic fragments of them are included, as are methods of making the bNAbs and antigenic fragments of them. HBV peptides for use as vaccines are provided, and include at least two non-overlapping epitopes from the HBsAg. Diagnostic reagents comprising the bNAbs or antigenic fragments thereof are provided, as are methods of detecting HBV and diagnosing HBV infection. |
| FILED | Friday, September 11, 2020 |
| APPL NO | 17/641396 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/20 (20180101) Peptides C07K 16/082 (20130101) Original (OR) Class C07K 2317/33 (20130101) C07K 2317/34 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220315646 | PERMAR et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sallie PERMAR (Durham, North Carolina); Mattia BONSIGNORI (Durham, North Carolina); Tulika SINGH (Durham, North Carolina); Kwan-Ki HWANG (Durham, North Carolina) |
| ABSTRACT | The invention is directed to antibodies, and antigen-binding fragments thereof, that potently neutralize infection of ZIKV. The invention also relates to antigenic sites to which the antibodies and antigen-binding fragments bind, as well as to nucleic acids that encode the antibodies of the invention, and immortalized B cells that produce such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies and antibody fragments of the invention in screening methods as well as in the diagnosis, prophylaxis and treatment of ZIKV infection. |
| FILED | Friday, September 11, 2020 |
| APPL NO | 17/642674 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220315665 | HEITZENEDER et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); THE CHILDREN'S HOSPITAL OF PHILADELPHIA (Philadelphia, Pennsylvania); THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by SECRETARY OF DEPARTMENT OF HEALTH (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sabine HEITZENEDER (Redwood City, California); Robbie G. MAJZNER (Palo Alto, California); Crystal L. MACKALL (Stanford, California); John M. MARIS (Philadelphia, Pennsylvania); Kristopher R. BOSSE (Philadelphia, Pennsylvania); Dimiter S. DIMITROV (Pittsburg, Pennsylvania); Zhongyu ZHU (Frederick, Maryland) |
| ABSTRACT | The present disclosure generally relates to, inter alia, antibodies and chimeric antigen receptors (CARs) that bind a Glypican 2 (GPC2) antigen. The disclosure also provides compositions and methods useful for producing such antibodies and CARs, as well as methods for the diagnosis, prevention, and/or treatment of health conditions associated with the GPC2 antigen expression. |
| FILED | Wednesday, May 06, 2020 |
| APPL NO | 17/608832 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 38/177 (20130101) A61K 38/1774 (20130101) A61K 39/39558 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 35/04 (20180101) Peptides C07K 14/70517 (20130101) C07K 14/70521 (20130101) C07K 14/70578 (20130101) C07K 16/303 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220315900 | Schlesinger et al. |
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| FUNDED BY |
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| APPLICANT(S) | TEXAS BIOMEDICAL RESEARCH INSTITUTE (San Antonio, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Larry S. Schlesinger (San Antonio, Texas); Susanta Pahari (San Antonio, Texas) |
| ABSTRACT | Provided here methods of generating human alveolar macrophage-like cells in-vitro from blood-derived monocytes by culturing them in a cell culture medium containing a mixture of a surfactant and two or more cytokines. This mixture can contain calfactant, granulocyte-macrophage colony-stimulating factor, transforming growth factor beta, and interleukin-10. |
| FILED | Wednesday, March 30, 2022 |
| APPL NO | 17/657344 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0688 (20130101) Original (OR) Class C12N 2501/15 (20130101) C12N 2501/22 (20130101) C12N 2501/231 (20130101) C12N 2506/115 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220315901 | EVANS et al. |
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| FUNDED BY |
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| APPLICANT(S) | SALK INSTITUTE FOR BIOLOGICAL STUDIES (LA JOLLA, California) |
| ASSIGNEE(S) | SALK INSTITUTE FOR BIOLOGICAL STUDIES (LA JOLLA, California) |
| INVENTOR(S) | RONALD EVANS (LA JOLLA, California); MICHAEL DOWNES (LA JOLLA, California); YASUYUKI KIDA (LA JOLLA, California); TERUHISA KAWAMURA (LA JOLLA, California); ZONG WEI (LA JOLLA, California); RUTH T. YU (LA JOLLA, California); ANNETTE R. ATKINS (LA JOLLA, California) |
| ABSTRACT | The invention generally features compositions comprising induced pluripotent stem cell progenitors (also termed reprogramming progenitor cells) and methods of isolating such cells. The invention also provides compositions comprising induced pluripotent stem cells (iPSCs) derived from such progenitor cells. Induced pluripotent stem cell progenitors generate iPSCs at high efficiency. |
| FILED | Tuesday, December 08, 2020 |
| APPL NO | 17/114888 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0696 (20130101) Original (OR) Class C12N 2501/39 (20130101) C12N 2506/02 (20130101) C12N 2506/1307 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220315902 | VUNJAK-NOVAKOVIC et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gordana VUNJAK-NOVAKOVIC (New York, New York); Keith YEAGER (Springfield, New Jersey); Kacey RONALDSON (New York, New York); Stephen MA (Layton, Utah); Timothy CHEN (New York, New York) |
| ABSTRACT | A cardiac organoid containing 3-D matter of adult human heart tissue. |
| FILED | Thursday, February 17, 2022 |
| APPL NO | 17/674196 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/34 (20130101) A61K 35/545 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/3826 (20130101) A61L 27/3895 (20130101) A61L 2430/20 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0657 (20130101) C12N 5/0697 (20130101) Original (OR) Class C12N 2503/04 (20130101) C12N 2506/45 (20130101) C12N 2513/00 (20130101) C12N 2529/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220315910 | ZHENG et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Yuxuan ZHENG (Davis, California); Claire LORENZO (Davis, California); Peter BEAL (Davis, California); Andrew FISHER (Davis, California); Leanna MONTELEONE (Davis, California) |
| ABSTRACT | In some aspects, the present invention provides methods and compositions for modifying target sites within nucleic acid molecules. In some embodiments, the methods comprise using adenosine deaminases that act on RNA (ADARs), and variants thereof, to modify target sites within DNA-RNA hybrid molecules. In other aspects, ADAR2 variant polypeptides as well as fusion proteins comprising an ADAR catalytic domain and a hybrid nucleic acid binding domain are provided, as are methods for use thereof. Methods for preventing and treating genetic disorders are also provided herein. |
| FILED | Monday, June 13, 2022 |
| APPL NO | 17/839233 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/16 (20130101) C12N 9/78 (20130101) Original (OR) Class C12N 15/62 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220315918 | Shendure et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Washington Through Its Center for Commercialization (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington Through Its Center for Commercialization (Seattle, Washington) |
| INVENTOR(S) | Jay Ashok Shendure (Seattle, Washington); Jerrod Joseph Schwartz (Seattle, Washington); Andrew Colin Adey (Seattle, Washington); Cho li Lee (Seattle, Washington); Joseph Brian Hiatt (Seattle, Washington); Jacob Otto Kitzman (Seattle, Washington); Akash Kumar (Seattle, Washington) |
| ABSTRACT | Contiguity information is important to achieving high-quality de novo assembly of mammalian genomes and the haplotype-resolved resequencing of human genomes. The methods described herein pursue cost-effective, massively parallel capture of contiguity information at different scales |
| FILED | Friday, April 08, 2022 |
| APPL NO | 17/716539 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1093 (20130101) Original (OR) Class Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 20/582 (20151101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220315920 | KE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cornell Universtiy (Ithaca, New York); The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ailong KE (Ithaca, New York); Adam DOLAN (Ithaca, New York); Yan ZHANG (Ann Arbor, Michigan); Zhonggang HOU (Ann Arbor, Michigan) |
| ABSTRACT | Provided are compositions, methods, and kits for CRISPR-based editing of DNA targets by Type I CRISPR-associated (Cas) enzymes. |
| FILED | Friday, June 21, 2019 |
| APPL NO | 17/254169 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) Original (OR) Class C12N 15/907 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220315933 | YAN |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of North Carolina Charlotte (Charlotte, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shan YAN (Charlotte, North Carolina) |
| ABSTRACT | The present application describes structures, systems, and methods for modeling and analysis of single-strand break (SSB) signaling and repair in a cell-free system. Also provided are methods of making the SSB structures and SSB signaling and repair systems. Methods and systems for identifying modulators of DNA damage response (DDR) activity for SSB repair are also described as well as methods of inhibiting SSB repair. |
| FILED | Thursday, April 21, 2022 |
| APPL NO | 17/726156 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/63 (20130101) Original (OR) Class C12N 15/1093 (20130101) C12N 2310/532 (20130101) C12N 2310/533 (20130101) C12N 2800/10 (20130101) C12N 2800/70 (20130101) C12N 2999/005 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/485 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/573 (20130101) G01N 2440/14 (20130101) G01N 2500/00 (20130101) G01N 2500/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220315934 | Badran et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts) |
| INVENTOR(S) | Ahmed H. Badran (Cambridge, Massachusetts); Natalie Kolber (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure relates to compositions and methods that enable enhanced monitoring and improvement of heterologous ribosome activity within a host cell. Specifically, the instant disclosure provides a reporter system that allows for improved monitoring of heterologous ribosome activity in a host cell, via engineering of both heterologous rRNA operon sequences and reporter operon sequences. New transgenic organisms harboring heterologous ribosome operons are also provided, as are methods for identifying agents capable of targeting heterologous ribosomes (e.g., ribosomes of pathogenic organisms, optionally selectively as compared to ribosomes of, e.g., commensal organisms) within a host cell. |
| FILED | Tuesday, July 14, 2020 |
| APPL NO | 17/626420 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/67 (20130101) Original (OR) Class C12N 15/1034 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220315948 | Corey et al. |
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| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); Ohio State Innovation Foundation (Columbus, Ohio); Massachusetts Eye and Ear Infirmary (Boston, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); Ohio State Innovation Foundation (Columbus, Ohio); Massachusetts Eye and Ear Infirmary (Boston, Massachusetts) |
| INVENTOR(S) | David P. Corey (Cambridge, Massachusetts); Artur Indzhykulian (Boston, Massachusetts); Marcos Sotomayor (Columbus, Ohio); Maryna V. lvanchenko (Cambridge, Massachusetts); Cole W. D. Peters (Cambridge, Massachusetts) |
| ABSTRACT | Aspects of the disclosure relate to compositions, nucleic acids, vectors, viruses, and methods useful for treating hearing loss and/or blindness, for example, Usher Syndrome type IF. The present disclosure provides isolated nucleic acids, vectors, and rAAV.9.PHP.B comprising a transgene encoding a mini-PCDH15, and methods of treating hearing loss using the same. The present disclosure also provides a gRNA associated with a base editor to correct one or more mutations in PCDH15 for treating hearing loss and/or vision loss. |
| FILED | Friday, April 24, 2020 |
| APPL NO | 17/606280 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/005 (20130101) Peptides C07K 14/705 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 15/90 (20130101) Enzymes C12Y 305/04004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220315967 | Tang et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Yi Tang (Arcadia, California); Yang Hai (Los Angeles, California) |
| ABSTRACT | Single-module nonribosomal peptide synthetases (NRPSs) and NRPS-like enzymes activate and transform carboxylic acids in both primary and secondary metabolism; and are of great interest due to their biocatalytic potentials. The single-module NRPS IvoA is essential for fungal pigment biosynthesis. As disclosed herein, we show that IvoA catalyzes ATP-dependent unidirectional stereoinversion of L-tryptophan to D-tryptophan with complete conversion. While the stereoinversion is catalyzed by the epimerization (E) domain, the terminal condensation (C) domain stereoselectively hydrolyzes D-tryptophanyl-S-phosphopantetheine thioester and thus represents a noncanonical C domain function. Using IvoA, we demonstrate a biocatalytic stereoinversion/deracemization route to access a variety of substituted D-tryptophan analogs in high enantiomeric excess. |
| FILED | Friday, September 18, 2020 |
| APPL NO | 17/640152 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/93 (20130101) C12N 9/1029 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 13/227 (20130101) Original (OR) Class Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/865 (20210501) Enzymes C12Y 203/01048 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220315982 | SETLIFF et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashhvikke, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marion Francis SETLIFF (Nashville, Tennessee); Ivelin Stefanov GEORGIEV (Brentwood, Tennessee); Andrea SHIAKOLAS (Nashville, Tennessee) |
| ABSTRACT | The present disclosure relates to a method for simultaneous detection of antigens and antigen specific antibodies. LIBRA-seq (Linking B Cell Receptor to Antigen specificity through sequencing) is developed to simultaneously recover both antigen specificity and paired heavy and light chain BCR sequence. LIBRA-seq is a next-generation sequencing-based readout for BCR-antigen binding interactions that utilizes oligonucleotides (oligos) conjugated to recombinant antigens. |
| FILED | Friday, September 04, 2020 |
| APPL NO | 17/640475 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1096 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/70 (20130101) C12Q 1/6804 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220316001 | ELLINGTON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew ELLINGTON (Austin, Texas); Cheulhee JUNG (Austin, Texas); Sheng CAI (Zhejiang, China PRC); Sanchita BHADRA (Austin, Texas); John N. MILLIGAN (Austin, Texas); Daniel GARRY (Austin, Texas); Raghav SHROFF (Austin, Texas) |
| ABSTRACT | Disclosed are compositions and methods for nucleic acid amplification and detection. Specifically, disclosed herein are compositions and methods that allow for amplification of nucleic acids at a wide variety of temperatures. This includes a polymerase which is thermostable at high temperatures, and a method of amplification that can be conducted at relatively low temperatures. |
| FILED | Wednesday, January 19, 2022 |
| APPL NO | 17/579085 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1252 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/6853 (20130101) Original (OR) Class C12Q 2521/101 (20130101) C12Q 2525/301 (20130101) C12Q 2527/101 (20130101) C12Q 2531/101 (20130101) C12Q 2537/1373 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220316002 | LINDSAY et al. |
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| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (SCOTTSDALE, Arizona) |
| ASSIGNEE(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (SCOTTSDALE, Arizona) |
| INVENTOR(S) | Stuart LINDSAY (Phoenix, Arizona); Bintian ZHANG (Tempe, Arizona); Hanqing DENG (Tempe, Arizona) |
| ABSTRACT | Disclosed are devices, systems and methods for direct measurement of polymerase activity. In one example, a device includes at least a first electrode and a second electrode, the first and second electrode being separated by a gap; and a polymerase with two attachment sites, one for attaching to the first electrode and a second for attaching to the second electrode, wherein the two attachment sites are separated by a distance of at least about 1 nm and the distance does not significantly change with conformational changes of the polymerase. |
| FILED | Friday, June 19, 2020 |
| APPL NO | 17/620566 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/005 (20130101) C12Q 1/6869 (20130101) Original (OR) Class Enzymes C12Y 207/07007 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/44791 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220316005 | Vogelstein et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bert Vogelstein (Baltimore, Maryland); Kenneth W. Kinzler (Baltimore, Maryland); Nickolas Papadopoulos (Towson, Maryland); Isaac A. Kinde (Beaumont, California) |
| ABSTRACT | The identification of mutations that are present in a small fraction of DNA templates is essential for progress in several areas of biomedical research. Though massively parallel sequencing instruments are in principle well-suited to this task, the error rates in such instruments are generally too high to allow confident identification of rare variants. We here describe an approach that can substantially increase the sensitivity of massively parallel sequencing instruments for this purpose. One example of this approach, called “Safe-SeqS” for (Safe-Sequencing System) includes (i) assignment of a unique identifier (UID) to each template molecule; (ii) amplification of each uniquely tagged template molecule to create UID-families; and (iii) redundant sequencing of the amplification products. PCR fragments with the same UID are truly mutant (“super-mutants”) if ≥95% of them contain the identical mutation. We illustrate the utility of this approach for determining the fidelity of a polymerase, the accuracy of oligonucleotides synthesized in vitro, and the prevalence of mutations in the nuclear and mitochondrial genomes of normal cells. |
| FILED | Friday, June 10, 2022 |
| APPL NO | 17/837591 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6869 (20130101) C12Q 1/6874 (20130101) Original (OR) Class C12Q 1/6876 (20130101) C12Q 2525/179 (20130101) C12Q 2525/191 (20130101) C12Q 2563/179 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220317017 | Lo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Yu-Hwa Lo (San Diego, California); Chun Hao Randy Chen (Arcadia, California); Sung Hwan Cho (La Jolla, California); Shang-Feng Tsai (Sunnyvale, California) |
| ABSTRACT | Microfluidic devices, systems and techniques in connection with particle sorting in liquid, including cytometry devices and techniques and applications in chemical or biological testing and diagnostic measurements. |
| FILED | Tuesday, June 14, 2022 |
| APPL NO | 17/806886 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1425 (20130101) Original (OR) Class G01N 15/1434 (20130101) G01N 15/1459 (20130101) G01N 15/1484 (20130101) G01N 2015/145 (20130101) G01N 2015/1006 (20130101) G01N 2015/1415 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220317115 | NAKAGAWA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YOURK (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hiroshi NAKAGAWA (New York, New York); Angela J. YOON (New York, New York); Anil K. RUSTGI (Villanova, Pennsylvania) |
| ABSTRACT | The present disclosure provides, inter alia, compositions and methods for treating or ameliorating the effects of a tumor in a subject comprising a three-dimensional (3D) organoid system. |
| FILED | Wednesday, June 08, 2022 |
| APPL NO | 17/835786 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/265 (20130101) A61K 31/513 (20130101) A61K 33/243 (20190101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0693 (20130101) C12N 2513/00 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/118 (20130101) C12Q 2600/156 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5085 (20130101) Original (OR) Class G01N 33/57407 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220317136 | Barthelemy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicolas Barthelemy (St. Louis, Missouri); Randall Bateman (St. Louis, Missouri); Eric McDade (ST. LOUIS, Missouri) |
| ABSTRACT | The present disclosure provides methods to quantify tau phosphorylation at specific amino acid residues to predict time to onset of mild cognitive impairment due to Alzheimer's disease, stage Alzheimer's disease, guide treatment decisions, select subjects for clinical trials, and evaluate the clinical efficacy of certain therapeutic interventions. |
| FILED | Friday, June 17, 2022 |
| APPL NO | 17/843470 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220318999 | XU et al. |
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| FUNDED BY |
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| APPLICANT(S) | YANZHE XU (Tempe, Arizona); TERESA WU (Gilbert, Arizona); FEI GAO (Sunnyvale, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | YANZHE XU (Tempe, Arizona); TERESA WU (Gilbert, Arizona); FEI GAO (Sunnyvale, California) |
| ABSTRACT | A system for blob detection using deep learning is disclosed. The system may include a non-transitory computer-readable storage medium configured to store a plurality of instructions thereon which, when executed by a processor, cause the system to train a U-Net and generate a probability map including a plurality of centroids of a plurality of corresponding blobs, derive two distance maps with bounded probabilities, apply Difference of Gaussian (DoG) with an adaptive scale constrained by the two distance maps with the bounded probabilities, and apply Hessian analysis and perform a blob segmentation. |
| FILED | Friday, March 18, 2022 |
| APPL NO | 17/698750 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 15/08 (20130101) G06T 2207/30084 (20130101) Image or Video Recognition or Understanding G06V 10/454 (20220101) G06V 10/7715 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220319689 | Teh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rehabilitation Institute of Chicago d/b/a Shirley Ryan Abilitylab (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yuni Teh (Chicago, Illinois); Levi Hargrove (Chicago, Illinois) |
| ABSTRACT | A system includes an input device in operable communication with a processor. The input device generates a plurality of signals representing an intended control of a prosthesis. The processor executes a predetermined pattern recognition (PR) control method that applies the plurality of input signals to at least one machine learning model trained using a training data set augmented with synthetic noise. The at least one machine learning model is configured to align the plurality of input signals to a low-dimensional manifold defining features and classify the features to identify a command for moving the prosthesis. The predetermined PR control method leverages the deep learning of the at least one machine learning model and the augmented training data to improve noise tolerance. |
| FILED | Wednesday, March 30, 2022 |
| APPL NO | 17/709133 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 40/63 (20180101) Original (OR) Class G16H 50/70 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220319715 | Adams, II et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | McMaster University (Hamilton, Canada); University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas A. Adams, II (Dundas, Canada); David Christian (Lansdale, Pennsylvania) |
| ABSTRACT | Computer-implemented systems and methods are provided for simulating immune response, including a processor operable to: determine a number of naive T-cells and a number of antigen-presenting cells within a system boundary; determine a number of bound naive T-cells within the system boundary based on the number of naive T-cells and the number of antigen-presenting cells within the system boundary; determine a number of bound primed T-cells within the system boundary based on the number of bound naive T-cells within the system boundary and the age of each bound naive T-cell; and determine a number of activated T-cells within the system boundary based on the number of bound primed T-cells within the system boundary and the age of each bound primed T-cell. |
| FILED | Wednesday, March 30, 2022 |
| APPL NO | 17/708261 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/50 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220319803 | Axelrod et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeremy J. Axelrod (Berkeley, California); Carter Turnbaugh (Berkeley, California); Sara Campbell (El Cerrito, California); Osip Schwartz (Albany, California); Robert M. Glaeser (Berkeley, California); Holger Mueller (Orinda, California) |
| ABSTRACT | A ponderomotive phase plate, also called a laser phase plate or standing wave optical phase plate, has a first minor and a second minor that define an optical cavity. An electron beam passes through a focal spot of the optical cavity. A laser with variable polarization angle of laser light is coupled to the optical cavity. A standing wave of polarized laser light, with an anti-node at the focal spot of the optical cavity, causes variable modulation of the electron beam. The variable modulation of the electron beam is controllable by the variable polarization angle of the laser light. In a transmission electron microscope, an image plane receives the electron beam modulated by the standing wave optical phase plate. An image formed at the image plane is based on the variable polarization angle of the polarized laser light. |
| FILED | Thursday, September 10, 2020 |
| APPL NO | 17/640255 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 37/22 (20130101) Original (OR) Class H01J 2237/2482 (20130101) H01J 2237/2614 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220321658 | Goodman |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rissana, LLC (St. Louis, Missouri) |
| ASSIGNEE(S) | Rissana, LLC (St. Louis, Missouri) |
| INVENTOR(S) | Micah Stone Goodman (Cambridge, Massachusetts) |
| ABSTRACT | User accounts can form any number of connections to any number of entities, enabling dynamic application functionality and data interaction regarding the user account and the connected entities. As a result, an individual can utilize the same user account and same application to access support from many entities. Entities may include social service organizations, groups of healthcare facilities, clinicians, medical devices, and other sources of support. The connection of a user account to an entity, updates the operations of the associated application system. For example, permissions regarding the transmission and modification of certain data associated with the user account and/or entity may be updated. Additionally, there may be additional functionality within software applications associated with the user account. There may be multiple possible forms of connections between a user account and a given entity, with each connection resulting in different outcomes. Connections can be removed and re-established as necessary. |
| FILED | Monday, April 04, 2022 |
| APPL NO | 17/712218 |
| CURRENT CPC | Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) G16H 80/00 (20180101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/102 (20130101) H04L 67/12 (20130101) Original (OR) Class H04L 67/306 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20220314183 | YEE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Daryl Wei Liang YEE (Pasadena, California); Julia R. GREER (Pasadena, California); Max L. LIFSON (Pasadena, California); Michael A. CITRIN (Pasadena, California) |
| ABSTRACT | In an aspect, a method for making a metal-containing material comprises steps of: forming a metal-containing hydrogel from an aqueous precursor mixture using a photopolymerization; wherein the aqueous precursor mixture comprises water, one or more aqueous photosensitive binders, and one or more aqueous metal salts; and thermally treating the metal-containing hydrogel to form the metal-containing material; wherein the metal-containing hydrogel is exposed to a thermal-treatment atmosphere during the step of thermally treating; wherein a composition of the metal-containing material is at least partially determined by a composition of the thermal-treatment atmosphere during the thermally treating step. |
| FILED | Thursday, March 31, 2022 |
| APPL NO | 17/710456 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 6/001 (20130101) B01J 13/0056 (20130101) Original (OR) Class B01J 13/0069 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 65/002 (20130101) C08G 2210/00 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/28 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/032 (20130101) G03F 7/0037 (20130101) G03F 7/0047 (20130101) G03F 7/70375 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/48 (20130101) H01M 4/133 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220314324 | LUO |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BATTELLE SAVANNAH RIVER ALLIANCE, LLC (Aiken, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | YUEFENG LUO (NORTH AUGUSTA, South Carolina) |
| ABSTRACT | Additive manufacturing systems and methods are provided. An additive manufacturing system includes a build volume; a powder disposed in the build volume, the powder occupying at least a portion of the build volume and having an outer boundary; a beam generator configured to generate a beam to irradiate the powder; and a ram defining a passthrough configured to transmit the beam to an irradiation location disposed within the outer boundary of the powder. |
| FILED | Thursday, November 04, 2021 |
| APPL NO | 17/518665 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/28 (20210101) Original (OR) Class B22F 12/37 (20210101) B22F 12/41 (20210101) B22F 12/67 (20210101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220315423 | Siriwardane |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States Department of Energy (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ranjani Siriwardane (Morgantown, West Virginia) |
| ABSTRACT | A catalytic method for producing gaseous products from a fuel and a gaseous reagent having the steps of: providing a catalyst and the fuel to a reactor vessel such that the catalyst and the fuel are in fluid communication with each other within the reactor vessel, where the catalyst is a mixture of reduced metal oxides; and contacting the fuel and catalyst with the gaseous reagent within the reactor vessel at a reaction temperature to produce gaseous products, where the gaseous reagent contains at least CO2 or H2O, where the fuel comprises a carbonaceous source, and wherein the gaseous products are CO or syngas. |
| FILED | Monday, March 21, 2022 |
| APPL NO | 17/699274 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 3/58 (20130101) C01B 3/326 (20130101) Original (OR) Class C01B 2203/0811 (20130101) C01B 2203/1076 (20130101) C01B 2203/1205 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220315436 | Ahn et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of The University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Juhyeon Ahn (Berkeley, California); Dongchang Chen (El Cerrito, California); Guoying Chen (Oakland, California) |
| ABSTRACT | This disclosure provides systems, methods, and apparatus related to lithium metal oxyfluorides. In one aspect, a method for manufacturing a lithium metal oxyfluoride having a general formula Li1+x(MM′)zO2-yFy, with 0.6≤z≤0.95, 0<y≤0.67, and 0.05≤x≤0.4, the lithium metal oxyfluoride having a cation-disordered rocksalt structure, includes: providing at least one lithium-based precursor; providing at least one redox-active transition metal-based precursor; providing at least one redox-inactive transition metal-based precursor; providing at least one fluorine-based precursor comprising a fluoropolymer; and mixing the at least one lithium-based precursor, the at least one redox-active transition metal-based precursor, the at least redox-inactive transition metal-based precursor, and the at least one fluorine-based precursor comprising a fluoropolymer to form a mixture. |
| FILED | Friday, October 15, 2021 |
| APPL NO | 17/502491 |
| CURRENT CPC | Compounds of Alkali Metals, i.e Lithium, Sodium, Potassium, Rubidium, Caesium, or Francium C01D 15/04 (20130101) Original (OR) Class Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 23/002 (20130101) C01G 33/006 (20130101) C01G 45/006 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/77 (20130101) C01P 2006/40 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0525 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220315443 | HATCHETT et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, (Las Vegas, Nevada) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David W. HATCHETT (Las Vegas, Nevada); Kenneth R. CZERWINSKI (Seattle, Washington); Katherine LUEBKE (Las Vegas, Nevada); Cassara HIGGINS (Las Vegas, Nevada) |
| ABSTRACT | Described are methods for the recovery of uranium from uranium hexafluoride dissolved directly into ionic liquids. |
| FILED | Friday, June 24, 2022 |
| APPL NO | 17/848809 |
| CURRENT CPC | Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 43/025 (20130101) C01G 43/063 (20130101) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/72 (20130101) C01P 2002/85 (20130101) C01P 2002/88 (20130101) C01P 2004/03 (20130101) Processes for the Electrolytic Production, Recovery or Refining of Metals; Apparatus Therefor C25C 3/34 (20130101) C25C 7/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220315550 | MITTAL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ashutosh MITTAL (Lakewood, Colorado); David Kenneth JOHNSON (Denver, Colorado) |
| ABSTRACT | Disclosed herein are the use of methods and compositions for the simultaneous dehydration of glucose and xylose present in a process relevant biorefinery hydrolysate to furfurals using heterogenous solid acid catalysts. |
| FILED | Monday, February 07, 2022 |
| APPL NO | 17/666493 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/12 (20130101) B01J 39/05 (20170101) Heterocyclic Compounds C07D 307/50 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220315681 | Lousenberg et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Compact Membrane Systems, Inc. (Newport, Delaware) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Daniel Lousenberg (Wilmington, Delaware); Andrew Edward Feiring (Wilmington, Delaware) |
| ABSTRACT | Novel copolymers that are fluoropolymers including a first repeat unit that is fluorinated and cyclic and a second repeat unit from a trifluorovinyl methylene ether monomer having sulfur or sulfone functionality in the pendant group are disclosed. The copolymers have relatively high gas permeability as a result of a cyclic repeat unit in the copolymer backbone and ionomers from oxidation of the sulfur containing functionality are particularity useful in the cathode structure of a proton exchange membrane fuel cell. |
| FILED | Wednesday, September 09, 2020 |
| APPL NO | 17/640231 |
| CURRENT CPC | Separation B01D 71/44 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 216/1408 (20130101) Original (OR) Class Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/1004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220315700 | Hernandez et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nacu Hernandez (Ames, Iowa); Mengguo Yan (San Jose, California); Eric William Cochran (Ames, Iowa); John Edward Matthiesen (Hillsboro, Oregon); Jean-Philippe Tessonnier (Ames, Iowa) |
| ABSTRACT | The present invention relates to a polymer comprising a repeating group having the structure of formula (I) wherein R, R1, R2, R3, R4, X, and s are as described herein and salt thereof. Also disclosed is a process of synthesizing such polymers. |
| FILED | Wednesday, June 15, 2022 |
| APPL NO | 17/841095 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 69/26 (20130101) C08G 69/28 (20130101) C08G 69/48 (20130101) C08G 69/265 (20130101) Original (OR) Class C08G 77/455 (20130101) C08G 81/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220315733 | Kumar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vipin Kumar (Oak Ridge, Tennessee); Ahmed A. Hassen (Oak Ridge, Tennessee); Christopher J. Hershey (Oak Ridge, Tennessee); Seokpum Kim (Oak Ridge, Tennessee); Vlastimil Kunc (Oak Ridge, Tennessee); John M. Lindahl (Oak Ridge, Tennessee) |
| ABSTRACT | The current embodiments include all-polymeric protective material for mitigating lightning strike damage. The protective material includes a hybrid matrix comprising PANI and MXene dispersed within a thermosetting epoxy resin. This hybrid matrix can be painted, printed, or applied as a conductive polymeric layer to a FRCP structure, for example an aircraft fuselage, wing, empennage, control surface (aileron, flap, slats, rudder, elevator) or a wind turbine blade. The protective material not only withstands lightning strikes, but also functions as shielding against electromagnetic interference and is corrosion-resistant and lightweight. |
| FILED | Wednesday, March 30, 2022 |
| APPL NO | 17/708210 |
| CURRENT CPC | Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 45/02 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/042 (20130101) C08J 7/044 (20200101) C08J 7/0427 (20200101) C08J 2300/24 (20130101) C08J 2400/12 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/14 (20130101) Original (OR) Class C08K 3/041 (20170501) C08K 2201/001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220315774 | Kumar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vipin Kumar (Oak Ridge, Tennessee); Justin C. Condon (Oak Ridge, Tennessee); Ahmed A. Hassen (Oak Ridge, Tennessee); Christopher J. Hershey (Oak Ridge, Tennessee); Seokpum Kim (Oak Ridge, Tennessee); Vlastimil Kunc (Oak Ridge, Tennessee); John M. Lindahl (Oak Ridge, Tennessee) |
| ABSTRACT | A polymeric adhesive film including a conductive filler of polyaniline (PANI) and MXene is provided. The adhesive film can be painted, printed, or applied to different substrate structures, including aircraft and wind turbine blades. The adhesive film has potential as a fatigue sensor, a strain sensor, a gas sensor, a humidity sensor, and a temperature sensor, by non-limiting example. In one embodiment, a force sensing material includes a conductive filler of PANI and MXene within an organic or polymer matrix. The force sensing material is used to measure local mechanical strain by detecting the change in electrical conductivity induced by the mechanical strain. The force sensing material can also be used in other applications where local strain changes, including the detection of local humidity and local temperature. |
| FILED | Wednesday, March 30, 2022 |
| APPL NO | 17/708088 |
| CURRENT CPC | Compositions of Macromolecular Compounds C08L 65/02 (20130101) C08L 79/02 (20130101) C08L 101/12 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/24 (20130101) Original (OR) Class Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/20 (20130101) H01B 1/128 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220315835 | Klimov et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Triad National Security, LLC (Los Alamos, New Mexico) |
| ASSIGNEE(S) | Triad National Security, LLC (Los Alamos, New Mexico) |
| INVENTOR(S) | Victor I. Klimov (Los Alamos, New Mexico); Hongbo Li (Los Alamos, New Mexico); Kaifeng Wu (Los Alamos, New Mexico); Jaehoon Lim (Los Alamos, New Mexico) |
| ABSTRACT | Disclosed herein are embodiments of a coated type-I quantum dot comprising a core and a shell, and a silica layer, and a method for making the quantum dot. The quantum dot may be a thick-shelled quantum dot. Also disclosed are embodiments of a composition comprising one or more coated quantum dots and a polymer. The composition may be a luminescent solar concentrator. Device comprising the composition are disclosed. The device may comprise the composition, such as a luminescent solar concentrator, applied to a substrate, such as glass. The device may be a window or a solar module. Also disclosed is a method of applying the composition to the substrate to form a thin film luminescent solar concentrator. |
| FILED | Thursday, February 17, 2022 |
| APPL NO | 17/674310 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 20/00 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/025 (20130101) Original (OR) Class C09K 11/883 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220315938 | Voytas et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel F. Voytas (Falcon Heights, Minnesota); Evan Ellison (Elbow Lake, Minnesota) |
| ABSTRACT | Methods and materials for increasing somatic and germline genome editing are provided herein. For example, provided herein are methods and materials for using augmented sgRNAs to increase somatic and germline genome editing. |
| FILED | Friday, August 07, 2020 |
| APPL NO | 17/634147 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/111 (20130101) C12N 15/825 (20130101) C12N 15/8203 (20130101) C12N 15/8213 (20130101) Original (OR) Class C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220315955 | BOMBLE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yannick J. BOMBLE (Arvada, Colorado); Petri Markus ALAHUHTA (Pine, Colorado); Simon James Bradshaw MALLINSON (Denver, Colorado); Michael E. HIMMEL (Littleton, Colorado) |
| ABSTRACT | Disclosed herein is a novel, cofactor balanced, cell-free biocatalysis pathway to make diacids from formaldehyde or methanol that does not use ATP and produces no CO2. In another embodiment, disclosed herein is a novel C5/C6 (hydrolysate) utilization pathway that interplays with the cell making diacids from formaldehyde or methanol that does not use ATP, produces no CO2, and replaces ATP with (cheap) polyphosphate (no other cofactors needed). Using methods and compositions disclosed herein, no CO2 is produced and the pathways disclosed herein are cell-free. The combination of pathways, feedstocks and products disclosed herein is novel. |
| FILED | Monday, April 04, 2022 |
| APPL NO | 17/713015 |
| CURRENT CPC | Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/52 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220316425 | Ernst et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CUMMINS INC. (Columbus, Indiana) |
| ASSIGNEE(S) | CUMMINS INC. (Columbus, Indiana) |
| INVENTOR(S) | Timothy C. Ernst (Columbus, Indiana); Jared Carpenter Delahanty (Morgantown, Indiana); Nathan Thomas Honican (North Vernon, Indiana) |
| ABSTRACT | A waste heat recovery system comprising a thermal circuit. The thermal circuit includes a boiler and an expander fluidly coupled to the boiler. The thermal circuit further includes a power transfer system integrated to the expander. The power transfer system is configured to receive mechanical energy from the expander. The thermal circuit further includes an ejector fluidly coupled to the boiler and to the power transfer system. The ejector is configured to receive a motive flow of working fluid from the boiler. The ejector is further configured to receive a suction flow of working fluid from the power transfer system. The ejector is further configured to combine the motive flow of working fluid and the suction flow of working fluid. |
| FILED | Wednesday, September 22, 2021 |
| APPL NO | 17/481863 |
| CURRENT CPC | Gas-flow Silencers or Exhaust Apparatus for Machines or Engines in General; Gas-flow Silencers or Exhaust Apparatus for Internal Combustion Engines F01N 5/02 (20130101) Hot Gas or Combustion-product Positive-displacement Engine Plants; Use of Waste Heat of Combustion Engines; Not Otherwise Provided for F02G 5/04 (20130101) Original (OR) Class F02G 2254/15 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220316438 | Siegel |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Atargis Energy Corporation (Pueblo, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stefan G. Siegel (Pueblo, Colorado) |
| ABSTRACT | A floating mooring system for a single CycWEC applies counter forces and torques to keep a generator suitably stationary for power generation without requiring fixed attachments to the ocean floor or requiring a large frame interconnecting multiple CycWECs. The mooring system uses floats or floatation structure with differential ballasting to counter operating torque and drag plates to counter reactive forces. The floatation structures may be used to float the CycWEC for transport to a deployment location, where changing the overall ballasting of the floatation structures submerges the CycWEC to a desired depth and differential ballasting in the floatation structures counts expected operating torques. |
| FILED | Wednesday, March 31, 2021 |
| APPL NO | 17/218828 |
| CURRENT CPC | Machines or Engines for Liquids F03B 13/10 (20130101) F03B 13/16 (20130101) Original (OR) Class F03B 13/18 (20130101) Indexing Scheme Relating to Wind, Spring, Weight, Inertia or Like Motors, to Machines or Engines for Liquids Covered by Subclasses F03B, F03D and F03G F05B 2220/32 (20130101) F05B 2240/95 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220316926 | LUBBERS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SPORIAN MICROSYSTEMS, INC. (Lafayette, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | JON LUBBERS (Lafayette, Colorado); Brittany McGrogan (Denver, Colorado); Duc Nguyen (Lakewood, Colorado); Bradley Smith (Westminster, Colorado); William VanHoose (Aurora, Colorado) |
| ABSTRACT | A high-temperature flow sensor includes strain relief wires for connecting cable wires to electrically resistive sensor elements to protect the sensor elements from fractures or other damage due to differences in thermal expansion and contraction of components. The resistive sensor material assembled with a support material is mounted in a tube with an electrically, conductive filler between the sensor material and the tube. |
| FILED | Wednesday, March 31, 2021 |
| APPL NO | 17/219301 |
| CURRENT CPC | Measuring Volume, Volume Flow, Mass Flow or Liquid Level; Metering by Volume G01F 1/69 (20130101) Original (OR) Class Resistors H01C 17/00 (20130101) Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors H01R 4/62 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220317002 | Shahedipour-Sandvik et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Research Foundation for the State University of New York (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fatemeh Shahedipour-Sandvik (Niskayuna, New York); Vincent Meyers (Albany, New York) |
| ABSTRACT | A system and method for annealing samples. The system includes a thermal shielding enclosure including a cavity, with a first surface, a second surface, a microwave emitter, a sensor and a control system. Additionally, the control system can adjust operational characteristics of the microwave emitter in response to determining whether the measured temperature of the sample is equal to or greater than a first predetermined temperature of the sample or is equal to or less than a second predetermined temperature of the sample. |
| FILED | Tuesday, March 29, 2022 |
| APPL NO | 17/707222 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/44 (20130101) Original (OR) Class Systems for Controlling or Regulating Non-electric Variables G05D 23/19 (20130101) Electric Heating; Electric Lighting Not Otherwise Provided for H05B 6/80 (20130101) H05B 6/645 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220317335 | Shalaev et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vladimir M. Shalaev (West Lafayette, Indiana); Alexandra Boltasseva (West Lafayette, Indiana); Alexei Lagutchev (West Lafayette, Indiana); Alexander Senichev (West Lafayette, Indiana); Zachariah O. Martin (West Lafayette, Indiana); Demid Sychev (West Lafayette, Indiana); Samuel Peana (West Lafayette, Indiana); Xiaohui Xu (Lafayette, Indiana) |
| ABSTRACT | A photon emitter includes a multi-layer film. The multi-layer film includes a first material layer and a second material layer, and the multi-layer film includes an interface surface between the first and second material layers. The first material layer includes silicon nitride. The multi-layer film is formed by positioning the silicon nitride over the second material layer and energetically activating the combination of the first material layer and the second material layer. The interface surface is operable to emit single photons. |
| FILED | Tuesday, April 05, 2022 |
| APPL NO | 17/713850 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) Optical Elements, Systems, or Apparatus G02B 1/002 (20130101) Original (OR) Class G02B 5/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220318525 | Kan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edwin C. Kan (Ithaca, New York); Xiaonan Hui (Ithaca, New York) |
| ABSTRACT | The present disclosure provides collaborative radiofrequency identification (RFID) readers that employ code division multiple access (CDMA) encoding to simultaneously broadcast to and read responses from tags in an overlapping reading zone with improved data synchronization and read yield rates. In some embodiments, a harmonic backscattering scheme is used to enable the system to have a much higher signal-to-noise ratio (SNR) and sensitivity, while the reader CDMA protocol can be integrated with an initial TDMA polling process or alternative tag CDMA scheme. |
| FILED | Monday, June 13, 2022 |
| APPL NO | 17/839325 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 7/10019 (20130101) Original (OR) Class G06K 19/0724 (20130101) Transmission H04B 5/0031 (20130101) H04B 5/0037 (20130101) H04B 7/216 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220318662 | Brown et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Department of Energy (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin A. Brown (Stonybrook, New York); Thomas G. Robertazzi (Mastic, New York) |
| ABSTRACT | One or more embodiments relates to a system and method for storing information in a storage ring. One embodiment relates to an architecture including at least one laser adapted to target and process at least one qubit in the storage ring; and an optical pathway in optical communication with the at least one laser, enabling the laser to process the at least one qubit. |
| FILED | Tuesday, March 29, 2022 |
| APPL NO | 17/706741 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/40 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220319803 | Axelrod et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeremy J. Axelrod (Berkeley, California); Carter Turnbaugh (Berkeley, California); Sara Campbell (El Cerrito, California); Osip Schwartz (Albany, California); Robert M. Glaeser (Berkeley, California); Holger Mueller (Orinda, California) |
| ABSTRACT | A ponderomotive phase plate, also called a laser phase plate or standing wave optical phase plate, has a first minor and a second minor that define an optical cavity. An electron beam passes through a focal spot of the optical cavity. A laser with variable polarization angle of laser light is coupled to the optical cavity. A standing wave of polarized laser light, with an anti-node at the focal spot of the optical cavity, causes variable modulation of the electron beam. The variable modulation of the electron beam is controllable by the variable polarization angle of the laser light. In a transmission electron microscope, an image plane receives the electron beam modulated by the standing wave optical phase plate. An image formed at the image plane is based on the variable polarization angle of the polarized laser light. |
| FILED | Thursday, September 10, 2020 |
| APPL NO | 17/640255 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 37/22 (20130101) Original (OR) Class H01J 2237/2482 (20130101) H01J 2237/2614 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220320526 | SONG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | West Virginia University (Morgantown, West Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xueyan SONG (Pittsburgh, Pennsylvania); Yun CHEN (Pittsburgh, Pennsylvania); Kirk GERDES (Morgantown, West Virginia) |
| ABSTRACT | In one aspect, the disclosure relates to method of forming an electrocatalyst structure on an electrode, comprising depositing a first layer on the electrode using atomic layer deposition (ALD), wherein the first layer comprises a plurality of discrete nanoparticles of a first electrocatalyst, and depositing one or more of a second layer on the first layer and the electrode using ALD, wherein the one or more second layer comprises a second electrocatalyst, wherein the first layer and the one or more second layers, collectively, form a multi-layer electrocatalyst structure on the electrode. Also disclosed are electrodes having a multi-layer electrocatalyst structure. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure. |
| FILED | Thursday, March 24, 2022 |
| APPL NO | 17/703977 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/06 (20130101) C23C 16/406 (20130101) C23C 16/45555 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/8621 (20130101) H01M 4/8657 (20130101) Original (OR) Class H01M 4/8867 (20130101) H01M 4/9025 (20130101) H01M 4/9058 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220320587 | Nanda et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jagjit Nanda (Knoxville, Tennessee); Guang Yang (Knoxville, Tennessee); Gabriel M. Veith (Knoxville, Tennessee) |
| ABSTRACT | A battery includes a cathode, an anode comprising Si, an electrolyte comprising glyme, and a lithium salt having at least one fluorine or boron atom in the anion. The glyme can have the formula CH3(OCH2CH2)nOCH3, where 1≤n≤4. The glyme can have the formula CnH2nOm, where 8≥n≥4 and 4≥m≥1. The electrolyte can further include an additive, wherein the additive has low solubility for the lithium salts such that the additive does not change the coordination of the ions in the glyme, has a viscosity<1 cP at 25° C., and is miscible with the glyme. An electrolyte for a battery and a method of making a battery are also discussed. |
| FILED | Tuesday, April 05, 2022 |
| APPL NO | 17/713449 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/58 (20130101) H01M 10/0525 (20130101) H01M 10/0567 (20130101) H01M 10/0568 (20130101) H01M 10/0569 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220320608 | Sarkar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Abhishek Sarkar (Ames, Iowa); Cajetan Ikenna Nlebedim (Ames, Iowa); Pranav Shrotiya (Ames, Iowa) |
| ABSTRACT | Fast charging of a lithium-ion battery at 4C rate or 5C rate or more is improved by applying an external magnetic field relative to the battery to establish magnetic field lines that extend in a direction of primary movement of lithium ions toward the graphite anode during fast charging. Deleterious degradation of the graphite anode from repeated fast charging can be reduced or eliminated by practice of the invention. |
| FILED | Monday, March 28, 2022 |
| APPL NO | 17/803239 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/133 (20130101) H01M 10/44 (20130101) Original (OR) Class H01M 2004/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220321664 | Rajagopal et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ram Rajagopal (Stanford, California); Gustavo Vianna Cezar (Stanford, California); Thomas Navidi (Stanford, California); Elizabeth Buechler (Stanford, California); Abbas El Gamal (Stanford, California) |
| ABSTRACT | A method and a system for managing power resources. One or more measurements received from one or more sensors communicatively coupled to at least one processor are processed. The sensors monitor and measure at least one of: one or more operational parameters associated with operation of at least one equipment, one or more external parameters associated with an environment of the equipment, and one or more power parameters associated with a power consumption by the equipment. Based on the processed one or more measurements, one or more future operational parameters associated with an operation of the are determined. The operation of the equipment is controlled using the determined future operational parameters. |
| FILED | Thursday, March 24, 2022 |
| APPL NO | 17/703621 |
| CURRENT CPC | Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/003 (20200101) Transmission of Digital Information, e.g Telegraphic Communication H04L 67/125 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220322235 | ODELBERG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| INVENTOR(S) | Trevor ODELBERG (Ann Arbor, Michigan); David WENTZLOFF (Ann Arbor, Michigan) |
| ABSTRACT | A low-power standard-compliant NB-IoT wake-up receiver (WRX) is presented. The WRX is designed as a companion radio to a full NB-IoT receiver, only operating during discontinuous RX modes (DRX and eDRX), which allows the full high-power radio to turn off while the wake-up receiver efficiently receives NB-IoTWake-Up Signals (WUS). The fabricated receiver achieves 2.1 mW power at −109 dBm sensitivity with 180 kHz bandwidth over the 750-960 MHz bands. The WRX is fabricated in 28 nm CMOS and consumes 5× less power than the best previously published traditional NB-IoT receivers. This disclosure is the first designed dedicated wake-up receiver for the NB-IoT protocol and demonstrates the benefits of utilizing a WRX to reduce power consumption of NB-IoT radios. |
| FILED | Wednesday, March 30, 2022 |
| APPL NO | 17/708017 |
| CURRENT CPC | Information and Communication Technology Specially Adapted for the Internet of Things [IOT] G16Y 10/75 (20200101) Amplifiers H03F 3/19 (20130101) H03F 2200/294 (20130101) H03F 2200/451 (20130101) Automatic Control, Starting, Synchronisation, or Stabilisation of Generators of Electronic Oscillations or Pulses H03L 7/08 (20130101) Wireless Communication Networks H04W 52/0235 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20220312748 | Casares et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America as Represented by the Secretary of the Navy (SIlver Spring, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sofia A. Casares (Potomac, Maryland); Teodor D. Brumeanu (Potomac, Maryland) |
| ABSTRACT | This invention relates to a transgenic animal model for testing immunogenicity and protective efficacy of human vaccines and the method for generating such a multi-transgenic animal. This invention also relates to methods for screening compositions for human vaccine development. More specifically, the present invention relates to a mouse model capable of expressing human leukocyte antigens DR4 and A2, and/or human costimulatory molecules (CD80) which upon infusion of human HLA-matched hematopoietic stem cells develop a functional human immune system able to respond to vaccination with human vaccines. The invention also relates to method of producing human antibodies specific for a desired antigen using the transgenic mouse. |
| FILED | Thursday, April 29, 2021 |
| APPL NO | 17/244302 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0278 (20130101) Original (OR) Class A01K 2207/12 (20130101) A01K 2217/15 (20130101) A01K 2217/052 (20130101) A01K 2217/075 (20130101) A01K 2227/105 (20130101) A01K 2267/01 (20130101) Peptides C07K 16/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/505 (20130101) G01N 33/6854 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220313387 | Reichenbach et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark Reichenbach (Lincoln, Nebraska); Shane Farritor (Lincoln, Nebraska) |
| ABSTRACT | Disclosed herein are gross positioning systems for use with robotic surgical devices to provide gross positioning of the robotic surgical devices. The gross positioning systems have a base, a first arm link operably coupled to the base, a second arm link operably coupled to the first arm link, a third arm link operably coupled to the second arm link, and a slidable coupling component slidably coupled to the third arm link. |
| FILED | Monday, June 13, 2022 |
| APPL NO | 17/838883 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/00149 (20130101) A61B 17/0206 (20130101) A61B 34/30 (20160201) A61B 34/73 (20160201) A61B 90/50 (20160201) Original (OR) Class A61B 2017/00477 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220313687 | Li et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Clear Scientific, Inc. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xinhua Li (Newton, Massachusetts); Mitchell Zakin (Andover, Massachusetts); Chandrashekar Shetty (Brookline, Massachusetts); Piercen Oliver (Malden, Massachusetts); Daniel Wallach (Melrose, Massachusetts) |
| ABSTRACT | Described herein are i) sequestering agents and ii) central nervous system (CNS) active agents for the treatment of intoxication due to toxic agents such as drugs of abuse, and associated symptoms. Also disclosed herein, are a cucurbituril and naloxone for use in the treatment of opioid overdoses through sequestering and excretion of the bound molecule of interest through the urine. Also provided herein, are kits and methods of treatment of the disclosure. |
| FILED | Thursday, February 10, 2022 |
| APPL NO | 17/669122 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/485 (20130101) Original (OR) Class A61K 31/551 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/36 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220313751 | Lyte et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark Lyte (Ames, Iowa); Daniel Nicholas Villageliu (Ames, Iowa) |
| ABSTRACT | The present invention is directed to synbiotic compositions of probiotic strains and prebiotics, along with uses thereof for targeted human and animal applications, for example, in promoting health and well-being and/or treating therapeutic conditions. The present invention is also directed to methods of probiotic selection and detection of strains with the ability to produce neurochemicals in the gastrointestinal tract of a subject, providing a microbial endocrinology-based mechanism and approach for optimization of synbiotic delivery of a probiotic with a neurochemical precursor. Still further the present invention is directed to industrial applications for production of dopamine utilizing methods and media suitable for the same. |
| FILED | Thursday, May 05, 2022 |
| APPL NO | 17/662188 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 31/198 (20130101) A61K 31/675 (20130101) A61K 35/744 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220313775 | Twiss et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of South Carolina (Columbia, South Carolina) |
| ASSIGNEE(S) | University of South Carolina (Columbia, South Carolina) |
| INVENTOR(S) | Jeffery L. Twiss (Columbia, South Carolina); Pabitra Sahoo (West Columbia, South Carolina) |
| ABSTRACT | Methods for using a peptide to effectively increase axon growth in both naive and injury-conditioned neurons. |
| FILED | Tuesday, June 14, 2022 |
| APPL NO | 17/839820 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220314168 | Dusenbury et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Army (Washington, District of Columbia) |
| ASSIGNEE(S) | Government of the United States, as represented by the Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | James Saye Dusenbury (Novi, Michigan); Jeremy Stephen Walker (Oakland, Michigan); Michael Jeffrey Anderson (Troy, Michigan) |
| ABSTRACT | A portable filtration system is described. The system may comprise: a mixing portion, comprising: a pump adaptor and a contaminant regulator. The pump adaptor may comprise: an upper plate, a lower plate, and a screen. The screen may axially extend between the upper and lower plates, wherein the upper plate, the lower plate, and the screen define a channel of a mixing chamber. The contaminant regulator may comprise a through-passage coupled to the upper plate, wherein the through-passage is in fluid communication with the mixing chamber. |
| FILED | Monday, April 05, 2021 |
| APPL NO | 17/222443 |
| CURRENT CPC | Separation B01D 61/10 (20130101) B01D 61/12 (20130101) B01D 61/025 (20130101) Original (OR) Class B01D 65/02 (20130101) B01D 2311/04 (20130101) B01D 2311/06 (20130101) B01D 2311/246 (20130101) B01D 2311/2649 (20130101) B01D 2313/18 (20130101) B01D 2321/02 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/008 (20130101) C02F 1/441 (20130101) C02F 2209/003 (20130101) C02F 2209/03 (20130101) C02F 2209/10 (20130101) C02F 2301/043 (20130101) C02F 2303/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220315689 | Kohl et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul A. Kohl (Atlanta, Georgia); Anthony Engler (Atlanta, Georgia) |
| ABSTRACT | The present disclosure relates to depolymerizable poly(aldehydes) and systems and methods of efficiently synthesizing the same. An exemplary method of making a polymer comprises continuously flowing a polymerization solution through at least a portion of a reactor, and generating a poly(aldehyde) polymer from the polymerization solution. |
| FILED | Monday, August 10, 2020 |
| APPL NO | 17/633646 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/24 (20130101) B01J 2219/00164 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 6/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220315891 | Amini |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trailhead Biosystems Inc. (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nooshin Amini (Cleveland, Ohio) |
| ABSTRACT | Methods for generating pre-oligodendrocyte progenitor cells (pre-OPCs) and oligodendrocyte progenitor cells (OPCs) from human pluripotent stem cells are provided using chemically-defined culture media that allow for generation of pre-OPCs and OPCs in as little as three days. Culture media, isolated cell populations and kits are also provided. |
| FILED | Friday, January 28, 2022 |
| APPL NO | 17/587552 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0622 (20130101) Original (OR) Class C12N 2501/41 (20130101) C12N 2501/155 (20130101) C12N 2501/385 (20130101) C12N 2501/415 (20130101) C12N 2501/727 (20130101) C12N 2506/02 (20130101) C12N 2506/45 (20130101) C12N 2533/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220315938 | Voytas et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel F. Voytas (Falcon Heights, Minnesota); Evan Ellison (Elbow Lake, Minnesota) |
| ABSTRACT | Methods and materials for increasing somatic and germline genome editing are provided herein. For example, provided herein are methods and materials for using augmented sgRNAs to increase somatic and germline genome editing. |
| FILED | Friday, August 07, 2020 |
| APPL NO | 17/634147 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/111 (20130101) C12N 15/825 (20130101) C12N 15/8203 (20130101) C12N 15/8213 (20130101) Original (OR) Class C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220315965 | Tracewell et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Zymergen Inc. (Emeryville, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cara Ann Tracewell (Walnut Creek, California); Alexander Glennon Shearer (San Francisco, California); Anupam Chowdhury (Emeryville, California); Steven M. Edgar (Albany, California) |
| ABSTRACT | The present disclosure describes the engineering of microbial cells for fermentative production of cystathionine and provides novel engineered microbial cells and cultures, as well as related cystathionine production methods. An engineered microbial cell that expresses a heterologous cystathionine beta-synthase or a heterologous cystathionine gamma-synthase, wherein the engineered microbial cell produces cystathionine. |
| FILED | Wednesday, June 24, 2020 |
| APPL NO | 17/619929 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0051 (20130101) C12N 9/88 (20130101) C12N 9/1085 (20130101) C12N 9/1205 (20130101) C12N 9/1241 (20130101) C12N 15/75 (20130101) C12N 15/77 (20130101) C12N 15/815 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 13/12 (20130101) Original (OR) Class Enzymes C12Y 108/04008 (20130101) C12Y 207/01025 (20130101) C12Y 207/07004 (20130101) C12Y 402/01022 (20130101) C12Y 404/01001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220316001 | ELLINGTON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew ELLINGTON (Austin, Texas); Cheulhee JUNG (Austin, Texas); Sheng CAI (Zhejiang, China PRC); Sanchita BHADRA (Austin, Texas); John N. MILLIGAN (Austin, Texas); Daniel GARRY (Austin, Texas); Raghav SHROFF (Austin, Texas) |
| ABSTRACT | Disclosed are compositions and methods for nucleic acid amplification and detection. Specifically, disclosed herein are compositions and methods that allow for amplification of nucleic acids at a wide variety of temperatures. This includes a polymerase which is thermostable at high temperatures, and a method of amplification that can be conducted at relatively low temperatures. |
| FILED | Wednesday, January 19, 2022 |
| APPL NO | 17/579085 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1252 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/6853 (20130101) Original (OR) Class C12Q 2521/101 (20130101) C12Q 2525/301 (20130101) C12Q 2527/101 (20130101) C12Q 2531/101 (20130101) C12Q 2537/1373 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220316037 | Aronhime et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Natan Aronhime (Pittsburgh, Pennsylvania); Michael E. McHenry (Pittsburgh, Pennsylvania); Vladimir Keylin (Pittsburgh, Pennsylvania) |
| ABSTRACT | A nanocomposite comprising crystalline grains in an amorphous matrix, the crystalline grains comprising an iron (Fe)-nickel (Ni) compound and being separated from one another by the amorphous matrix; and one or more barriers between the crystalline grains and the amorphous matrix, the barriers being configured to inhibit growth of the crystalline grains during forming of the crystalline grains, a barrier of the one or more barriers being between a crystalline grain and the amorphous matrix; wherein the amorphous matrix comprises an increased resistivity relative to a resistivity of the crystalline grains; and wherein the amorphous matrix is configured to reduce losses of the crystalline grains caused by a change in a magnetic field applied to the crystalline grains relative to losses of the crystalline grains that occur without the amorphous matrix. |
| FILED | Friday, June 05, 2020 |
| APPL NO | 17/617173 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 15/011 (20130101) B32B 2457/00 (20130101) Modifying the Physical Structure of Ferrous Metals; General Devices for Heat Treatment of Ferrous or Non-ferrous Metals or Alloys; Making Metal Malleable, e.g by Decarburisation or Tempering C21D 2201/03 (20130101) Alloys C22C 38/02 (20130101) C22C 38/08 (20130101) C22C 38/12 (20130101) Original (OR) Class C22C 2200/04 (20130101) C22C 2202/02 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 1/14733 (20130101) H01F 1/15308 (20130101) H01F 1/15333 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220316108 | Dion et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Drexel University (Philadelphia, Pennsylvania); The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Genevieve Eugenie Dion (Philadelphia, Pennsylvania); Chelsea Elizabeth Amanatides (Philadelphia, Pennsylvania); Randall Kamien (Philadelphia, Pennsylvania) |
| ABSTRACT | A method for designing a knitted textile or fabric, the method includes receiving graphical input from a user regarding a knit pattern comprised of different types of individual stitches to be included in a textile or fabric design. The method further includes graphically displaying a representation of the textile or fabric design. The method further includes merging sections of continuous stitches of the same type into at least one block. The method further includes graphically displaying the textile or fabric design as a pattern of the at least one block. The method further includes applying edge rolling indicators and/or folding indicators to the displayed pattern of the at least one block, where the edge rolling and/or folding indicators respectively and graphically illustrate predicted edge rolling and folding behaviors of a physical textile or fabric. |
| FILED | Thursday, March 31, 2022 |
| APPL NO | 17/710915 |
| CURRENT CPC | Knitting D04B 1/102 (20130101) D04B 15/80 (20130101) Original (OR) Class D04B 21/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220316836 | Hammel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Rand W. Hammel (Springville, Indiana); Alex J. Toon (Odon, Indiana); Donald Richardville (Montgomery, Indiana) |
| ABSTRACT | Provided is an interchangeable modular chamber system for a firearm. The system includes a firearm receiver, a barrel comprising lands and grooves, a chamber insert sleeve comprising lands and grooves, an index pin, a locking collar, and a recoil lug. The barrel is threaded into the receiver with the chamber insert sleeve positioned within the barrel. The chamber insert sleeve is indexed to align the lands and grooves of the chamber insert sleeve with those of the barrel. The locking collar and recoil lug are threaded onto the external threads of the barrel and are adjustable to optimize the headspace for different cartridges of the same caliber and to allow for the sacrificial replacement of the throat area of a barrel. |
| FILED | Wednesday, April 06, 2022 |
| APPL NO | 17/714219 |
| CURRENT CPC | Functional Features or Details Common to Both Smallarms and Ordnance, e.g Cannons; Mountings for Smallarms or Ordnance F41A 21/18 (20130101) F41A 21/482 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220316864 | Sheng et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jian Sheng (Corpus Christi, Texas); Maryam Jalali-Mousavi (Woodbury, Minnesota) |
| ABSTRACT | In an embodiment, the present disclosure pertains to a method of performing circulating tumor cell (CTC) analysis. In general, the method includes flowing a sample through a CTC microfluidic platform, deforming a CTC within the sample, measuring CTC deformation through an imprint of the deformed CTC, processing data related to the measuring, and at least one of identifying or characterizing parameters related to the data that enables at least one of detection of CTCs, enumeration of CTCs in the sample, characterization of biophysical properties, CTC cell size, CTC cell membrane deformability, stresses on CTC cell membranes, adhesion stress on CTC cells, normal stress of CTC cells, or combinations thereof. In some embodiments, the flowing includes passing the sample through at least one channel of the CTC microfluidic platform having a constricted section. |
| FILED | Wednesday, April 06, 2022 |
| APPL NO | 17/714545 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 2300/168 (20130101) B01L 2300/0663 (20130101) Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 11/16 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220317009 | Stoll et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Kyle D. Stoll (Montgomery, Indiana); Eric Scheid (Bloomington, Indiana) |
| ABSTRACT | Provided is a new and improved method for examining the penetration of fragments in ballistic gelatin through the use of state-of-the art computed tomography (CT) equipment and analytical software. The inventive method can be used for fragment penetration testing as a key performance parameter (KPP). Ballistic gel containing multiple fragments are obtained, placed in a container, positioned in a CT chamber, and scanned. The scan is imported into a Volume graphics software program. A surface determination is made, which is used by one or more algorithms to isolate potential fragmentation within the gel block. The number of fragments, depth of penetration, and fragment mass are then calculated. |
| FILED | Thursday, March 31, 2022 |
| APPL NO | 17/709952 |
| CURRENT CPC | Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 35/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 9/36 (20130101) Original (OR) Class G01N 23/18 (20130101) G01N 23/046 (20130101) G01N 2223/401 (20130101) Image Data Processing or Generation, in General G06T 5/002 (20130101) G06T 7/0002 (20130101) G06T 7/62 (20170101) G06T 2207/10081 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220317283 | Estep et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Patrick Estep (Rowlett, Texas); Tony M. Brewer (Plano, Texas); Bryan Hornung (Plano, Texas); Douglas Vanesko (Dallas, Texas) |
| ABSTRACT | A synthetic-aperture radar (SAR) antenna emits radar pulses and receives their reflections. SAR is typically used on a moving platform, such as an aircraft, drone, or spacecraft. Since the position of the antenna changes between the time of emitting a radar pulse and receiving the reflection of the pulse, the synthetic aperture of the radar is increased, giving greater accuracy for a same (physical) sized radar over conventional beam-scanning radar. The pulse data is processed, using a backprojection algorithm, to generate a two-dimensional image that can be used for navigation. The order in which the SAR data is processed can impact the likelihood of cache hits in accessing the data. Since accessing data from cache instead of memory storage reduces both access time and power consumption, devices that access more data from cache have greater battery life and range. |
| FILED | Monday, April 26, 2021 |
| APPL NO | 17/240548 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 13/9005 (20130101) G01S 13/9021 (20190501) Original (OR) Class G01S 13/9056 (20190501) Electric Digital Data Processing G06F 12/0815 (20130101) G06F 2212/1021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220317887 | Brewer |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tony Brewer (Plano, Texas) |
| ABSTRACT | Devices and techniques for managing hazards in a memory controller are described herein. The memory controller can receive a memory request that includes a base memory address. An index can be computed from the base memory address and a lookup, using the index, can be performed to find a lock. When the lock is found, the memory controller can store the memory request in a buffer that corresponds to the lock. In response to a signal to clear the lock, the memory controller removes the memory request from the buffer and performs the memory request. |
| FILED | Tuesday, October 20, 2020 |
| APPL NO | 17/075365 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/0613 (20130101) Original (OR) Class G06F 3/0631 (20130101) G06F 3/0673 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220317972 | Vanesko et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Douglas Vanesko (Dallas, Texas); Tony M. Brewer (Plano, Texas); Bryan Hornung (Plano, Texas); Patrick Estep (Rowlett, Texas) |
| ABSTRACT | Devices and techniques for hardware for concurrent SINE and cosine determination are described herein. A first sequence of bits representing an angle of a line from an origin to a unit circle can be obtained. A quadrant of the unit circle for the line is determined and the two least significant bits of the first sequence of bits is replaced with an encoding for the quadrant, the angle is translated to a base quadrant angle and sin and cosine operations are performed on a portion of a second sequence of bits (derived from the first sequence of bits) to create intermediate sin and cosine solutions in the base quadrant. The quadrant encoding in the first sequence of bits is then used to create a final sin and cosine solutions in the quadrant from the intermediate solutions. |
| FILED | Wednesday, August 18, 2021 |
| APPL NO | 17/405368 |
| CURRENT CPC | Electric Digital Data Processing G06F 7/548 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220318156 | Brewer |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tony M. Brewer (Plano, Texas) |
| ABSTRACT | Devices and techniques to avoid deadlock in a multi-SOC fabric are described herein. An apparatus comprises a network on chip (NOC) interface to receive on a first virtual channel, from a processor, a memory request for a memory controller; a fabric interface configured to include the first virtual channel and a second virtual channel, connected to a scale fabric; and circuitry to: transmit the memory request toward the memory controller on the first virtual channel via the scale fabric; receive a response from the memory controller over the second virtual channel via the scale fabric; and relay the response to the processor over the second virtual channel. |
| FILED | Friday, August 27, 2021 |
| APPL NO | 17/459312 |
| CURRENT CPC | Electric Digital Data Processing G06F 12/109 (20130101) Original (OR) Class G06F 2212/657 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220318162 | Hornung et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bryan Hornung (Plano, Texas); Tony M. Brewer (Plano, Texas); Douglas Vanesko (Dallas, Texas); Patrick Estep (Rowlett, Texas) |
| ABSTRACT | Linear interpolation is performed within a memory system. The memory system receives a floating-point point index into an integer-indexed memory array. The memory system accesses the two values of the two adjacent integer indices, performs the linear interpolation, and provides the resulting interpolated value. In many system architectures, the critical limitation on system performance is the data transfer rate between memory and processing elements. Accordingly, reducing the amount of data transferred improves overall system performance and reduces power consumption. |
| FILED | Monday, April 26, 2021 |
| APPL NO | 17/240492 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/41 (20130101) G01S 13/933 (20200101) G01S 13/9021 (20190501) Electric Digital Data Processing G06F 9/3001 (20130101) G06F 9/3887 (20130101) G06F 13/1668 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220318163 | Brewer |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tony M. Brewer (Plano, Texas) |
| ABSTRACT | A system includes multiple memory-compute nodes coupled to one another over a scale fabric, where each memory-compute node includes a hybrid threading processor; a memory controller; a fabric interface; and a network on chip (NOC) that provides communication between the hybrid threading processor, the fabric interface, and the memory controller, wherein the fabric interface supports a first virtual channel (VC0), and a second virtual channel (VC1) to the NOC, and supports the first virtual channel (VC0), the second virtual channel (VC1), and a third virtual channel (VC2) to the scale fabric. |
| FILED | Friday, August 27, 2021 |
| APPL NO | 17/459525 |
| CURRENT CPC | Electric Digital Data Processing G06F 13/1668 (20130101) Original (OR) Class G06F 13/4027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220318437 | POMERANCE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Andrew Joseph POMERANCE (Alexandria, Virginia); Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Joseph POMERANCE (Alexandria, Virginia); Daniel GAUTHIER (Hilliard, Ohio); Daniel CANADAY (Columbus, Ohio); Noeloikeau CHARLOT (Kailua, Hawaii) |
| ABSTRACT | Systems, devices, and methods for generating a unique fingerprint are described herein. For example, an example integrated circuit (IC) chip includes a physically unclonable function (PUF) and an auxiliary circuit. The PUF is a hybrid Boolean network. Additionally, the auxiliary circuit is configured to receive a transient response enable signal. |
| FILED | Tuesday, April 07, 2020 |
| APPL NO | 17/616964 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/76 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220318569 | Nataraj et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Mayachitra, Inc. (Santa Barbara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lakshmanan Nataraj (Chennai, India); Tajuddin Manhar Mohammed (Goleta, California); Tejaswi Nanjundaswamy (San Jose, California); Michael Gene Goebel (Santa Barbara, California); Bangalore S. Manjunath (Santa Barbara, California); Shivkumar Chandrasekaran (Santa Barbara, California) |
| ABSTRACT | Systems, devices, methods and instructions are described for detecting GAN generated images. On embodiment involves receiving an images, generating co-occurrence matrices on color channels of the image, generating analysis of the image by using a convolutional neural network trained to analyze image features of the images based on the generated co-occurrence matrices and determining whether the image is a GAN generated image based on the analysis. |
| FILED | Tuesday, June 07, 2022 |
| APPL NO | 17/834455 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6257 (20130101) Original (OR) Class G06K 9/6262 (20130101) Computer Systems Based on Specific Computational Models G06N 3/088 (20130101) G06N 3/0454 (20130101) Image or Video Recognition or Understanding G06V 10/56 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220320358 | Derkacs |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SolAero Technologies Corp. (Albuquerque, New Mexico) |
| ASSIGNEE(S) | SolAero Technologies Corp. (Albuquerque, New Mexico) |
| INVENTOR(S) | Daniel Derkacs (Albuquerque, New Mexico) |
| ABSTRACT | A multijunction solar cell including an upper first solar subcell having a first band gap and positioned for receiving an incoming light beam; a second solar subcell disposed below and adjacent to and lattice matched with said upper first solar subcell, and having a second band gap smaller than said first band gap; wherein the ratio of the thickness of the emitter layer to the thickness of the base layer in at least one of the solar subcells is between 5:1 and 1:1. |
| FILED | Thursday, April 01, 2021 |
| APPL NO | 17/219994 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/0547 (20141201) H01L 31/0725 (20130101) Original (OR) Class H01L 31/0735 (20130101) H01L 31/1844 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20220312710 | Paige |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ken N. Paige (Monticello, Illinois) |
| ABSTRACT | A method for increasing yield or vigor of a plant is provided, which includes the selective removal of the plant's shoot apical meristem at a period between vegetative growth stage 1 and vegetative growth stage 2, or between vegetative growth stage 2 and vegetative growth stage 3. |
| FILED | Monday, August 31, 2020 |
| APPL NO | 17/640403 |
| CURRENT CPC | Horticulture; Cultivation of Vegetables, Flowers, Rice, Fruit, Vines, Hops or Seaweed; Forestry; Watering A01G 7/00 (20130101) New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 3/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220313358 | Arnold et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Worcester Polytechnic Institute (Worcester, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrea Arnold (Worcester, Massachusetts); Loris Fichera (Boston, Massachusetts) |
| ABSTRACT | A method of assessing optical properties of surgical tissue by observing the tissue thermal response to laser irradiation includes exposing the tissue in a surgical region to a short laser pulse for triggering a localized temperature increase, and observing the triggered temperature increase by a thermal sensor. Optical properties of the tissue are then estimated, for determining laser surgery parameters for an eminent procedure, based on the observed temperature increase. In an example configuration, the thermal sensor is a thermal infrared camera, and estimation includes using an Ensemble Kalman Filter (EnKF) for comparing the temperature sensor data with the output of a computational laser-tissue interaction model. |
| FILED | Friday, April 01, 2022 |
| APPL NO | 17/711100 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 18/20 (20130101) Original (OR) Class A61B 2018/00636 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/067 (20210801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220313624 | DONG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California) |
| ASSIGNEE(S) | THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California) |
| INVENTOR(S) | Jiajia DONG (Shanghai city, China PRC); K. Barry SHARPLESS (La Jolla, California); Jeffery W. KELLY (La Jolla, California); Aleksandra BARANCZAK (Gurnee, Illinois); Wentao CHEN (Walnut Creek, California) |
| ABSTRACT | Described herein are compounds comprising a biologically active organic core group with one to five —Z—(X1—S(O)(X2)F)m groups attached thereto, wherein Z is O, NR, or N; X1 is a covalent bond or CH2CH2; m can be 1 or 2 depending on the identity of Z; and X2 is O or NR. In some embodiments, the core group is an amino acid or a protein. In some embodiments the core group is a compound that has therapeutic activity toward a therapeutic target. |
| FILED | Friday, May 27, 2022 |
| APPL NO | 17/826660 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/05 (20130101) Original (OR) Class A61K 31/14 (20130101) A61K 31/40 (20130101) A61K 31/47 (20130101) A61K 31/53 (20130101) A61K 31/56 (20130101) A61K 31/65 (20130101) A61K 31/70 (20130101) A61K 31/136 (20130101) A61K 31/197 (20130101) A61K 31/198 (20130101) A61K 31/397 (20130101) A61K 31/407 (20130101) A61K 31/439 (20130101) A61K 31/473 (20130101) A61K 31/485 (20130101) A61K 31/505 (20130101) A61K 31/515 (20130101) A61K 31/655 (20130101) A61K 31/4045 (20130101) A61K 31/4168 (20130101) A61K 31/4245 (20130101) A61K 31/4353 (20130101) A61K 31/4709 (20130101) A61K 31/4745 (20130101) A61K 31/5513 (20130101) A61K 31/7048 (20130101) A61K 38/31 (20130101) A61K 47/54 (20170801) A61K 51/0497 (20130101) Acyclic or Carbocyclic Compounds C07C 305/26 (20130101) C07C 2601/14 (20170501) C07C 2603/18 (20170501) Heterocyclic Compounds C07D 277/82 (20130101) C07D 279/08 (20130101) C07D 295/26 (20130101) C07D 295/088 (20130101) C07D 295/185 (20130101) C07D 501/18 (20130101) Peptides C07K 1/02 (20130101) C07K 1/1136 (20130101) C07K 2/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220313687 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Clear Scientific, Inc. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xinhua Li (Newton, Massachusetts); Mitchell Zakin (Andover, Massachusetts); Chandrashekar Shetty (Brookline, Massachusetts); Piercen Oliver (Malden, Massachusetts); Daniel Wallach (Melrose, Massachusetts) |
| ABSTRACT | Described herein are i) sequestering agents and ii) central nervous system (CNS) active agents for the treatment of intoxication due to toxic agents such as drugs of abuse, and associated symptoms. Also disclosed herein, are a cucurbituril and naloxone for use in the treatment of opioid overdoses through sequestering and excretion of the bound molecule of interest through the urine. Also provided herein, are kits and methods of treatment of the disclosure. |
| FILED | Thursday, February 10, 2022 |
| APPL NO | 17/669122 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/485 (20130101) Original (OR) Class A61K 31/551 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/36 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220315529 | Xu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qiaobing Xu (Lexington, Massachusetts); Yamin Li (Somerville, Massachusetts) |
| ABSTRACT | Disclosed are noncationic lipidoid nanoparticles (LNPs) for His-tagged protein delivery. |
| FILED | Friday, July 31, 2020 |
| APPL NO | 17/631769 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5123 (20130101) A61K 9/5146 (20130101) A61K 45/06 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Acyclic or Carbocyclic Compounds C07C 229/26 (20130101) C07C 321/18 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220315700 | Hernandez et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nacu Hernandez (Ames, Iowa); Mengguo Yan (San Jose, California); Eric William Cochran (Ames, Iowa); John Edward Matthiesen (Hillsboro, Oregon); Jean-Philippe Tessonnier (Ames, Iowa) |
| ABSTRACT | The present invention relates to a polymer comprising a repeating group having the structure of formula (I) wherein R, R1, R2, R3, R4, X, and s are as described herein and salt thereof. Also disclosed is a process of synthesizing such polymers. |
| FILED | Wednesday, June 15, 2022 |
| APPL NO | 17/841095 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 69/26 (20130101) C08G 69/28 (20130101) C08G 69/48 (20130101) C08G 69/265 (20130101) Original (OR) Class C08G 77/455 (20130101) C08G 81/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220315706 | BOWMAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (DENVER, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | CHRISTOPHER N. BOWMAN (BOULDER, Colorado); MARVIN DION ALIM (KIRKLAND, Washington); MATTHEW K. MCBRIDE (BOULDER, Colorado); KIMBERLY KAY-CHILDRESS (BOULDER, Colorado); JUAN J. HERNANDEZ (LONGMONT, Colorado); JEFFREY W. STANSBURY (CENTENNIAL, Colorado) |
| ABSTRACT | In one aspect, the disclosure relates to compositions comprising semicrystalline, linear photopolymers that possesses extraordinary mechanical properties for application in 3D printing. The photopolymers are rapidly fabricated using low viscosity liquids at ambient conditions. |
| FILED | Monday, June 08, 2020 |
| APPL NO | 17/616922 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 70/00 (20141201) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 2/50 (20130101) C08F 218/16 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 75/045 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220315914 | Doudna et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jennifer A. Doudna (Berkeley, California); Enbo Ma (Moraga, California); Junjie Liu (Berkeley, California) |
| ABSTRACT | The present disclosure provides variant type V CRISPR/Cas effector polypeptides, nucleic acids encoding the variant polypeptides, and systems comprising the variant polypeptides or nucleic acids encoding same. The present disclosure provides methods for modifying a target nucleic acid, using a variant polypeptide of the present disclosure. |
| FILED | Monday, July 06, 2020 |
| APPL NO | 17/619815 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) C12N 15/82 (20130101) C12N 15/85 (20130101) C12N 15/102 (20130101) Original (OR) Class C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220316001 | ELLINGTON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew ELLINGTON (Austin, Texas); Cheulhee JUNG (Austin, Texas); Sheng CAI (Zhejiang, China PRC); Sanchita BHADRA (Austin, Texas); John N. MILLIGAN (Austin, Texas); Daniel GARRY (Austin, Texas); Raghav SHROFF (Austin, Texas) |
| ABSTRACT | Disclosed are compositions and methods for nucleic acid amplification and detection. Specifically, disclosed herein are compositions and methods that allow for amplification of nucleic acids at a wide variety of temperatures. This includes a polymerase which is thermostable at high temperatures, and a method of amplification that can be conducted at relatively low temperatures. |
| FILED | Wednesday, January 19, 2022 |
| APPL NO | 17/579085 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1252 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/6853 (20130101) Original (OR) Class C12Q 2521/101 (20130101) C12Q 2525/301 (20130101) C12Q 2527/101 (20130101) C12Q 2531/101 (20130101) C12Q 2537/1373 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220316037 | Aronhime et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Natan Aronhime (Pittsburgh, Pennsylvania); Michael E. McHenry (Pittsburgh, Pennsylvania); Vladimir Keylin (Pittsburgh, Pennsylvania) |
| ABSTRACT | A nanocomposite comprising crystalline grains in an amorphous matrix, the crystalline grains comprising an iron (Fe)-nickel (Ni) compound and being separated from one another by the amorphous matrix; and one or more barriers between the crystalline grains and the amorphous matrix, the barriers being configured to inhibit growth of the crystalline grains during forming of the crystalline grains, a barrier of the one or more barriers being between a crystalline grain and the amorphous matrix; wherein the amorphous matrix comprises an increased resistivity relative to a resistivity of the crystalline grains; and wherein the amorphous matrix is configured to reduce losses of the crystalline grains caused by a change in a magnetic field applied to the crystalline grains relative to losses of the crystalline grains that occur without the amorphous matrix. |
| FILED | Friday, June 05, 2020 |
| APPL NO | 17/617173 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 15/011 (20130101) B32B 2457/00 (20130101) Modifying the Physical Structure of Ferrous Metals; General Devices for Heat Treatment of Ferrous or Non-ferrous Metals or Alloys; Making Metal Malleable, e.g by Decarburisation or Tempering C21D 2201/03 (20130101) Alloys C22C 38/02 (20130101) C22C 38/08 (20130101) C22C 38/12 (20130101) Original (OR) Class C22C 2200/04 (20130101) C22C 2202/02 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 1/14733 (20130101) H01F 1/15308 (20130101) H01F 1/15333 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220316108 | Dion et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Drexel University (Philadelphia, Pennsylvania); The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Genevieve Eugenie Dion (Philadelphia, Pennsylvania); Chelsea Elizabeth Amanatides (Philadelphia, Pennsylvania); Randall Kamien (Philadelphia, Pennsylvania) |
| ABSTRACT | A method for designing a knitted textile or fabric, the method includes receiving graphical input from a user regarding a knit pattern comprised of different types of individual stitches to be included in a textile or fabric design. The method further includes graphically displaying a representation of the textile or fabric design. The method further includes merging sections of continuous stitches of the same type into at least one block. The method further includes graphically displaying the textile or fabric design as a pattern of the at least one block. The method further includes applying edge rolling indicators and/or folding indicators to the displayed pattern of the at least one block, where the edge rolling and/or folding indicators respectively and graphically illustrate predicted edge rolling and folding behaviors of a physical textile or fabric. |
| FILED | Thursday, March 31, 2022 |
| APPL NO | 17/710915 |
| CURRENT CPC | Knitting D04B 1/102 (20130101) D04B 15/80 (20130101) Original (OR) Class D04B 21/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220317057 | FARIA BRICENO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Juan Jose FARIA BRICENO (Albuquerque, New Mexico); Steven R.J. BRUECK (Albuquerque, New Mexico) |
| ABSTRACT | A system for measuring a periodic array of structures on a sample is provided. The system includes an optical source configured to produce an optical beam; an optical system configured to control the polarization of the optical beam and to focus the optical beam with a first NA1 on a sample surface and to sweep the angle of incidence across a range of angles with an approximately fixed focal position on a sample surface with a second NA2 wherein NA2>NA1; additional optical components configured to receive the optical beam reflected from the sample surface and to focus the reflected beam onto a detector; and a recording system to record the reflectivity of the sample surface as a function of the angle of incidence. In an embodiment, the optical system provides a spot on the sample such that both the angle of incidence and the position on the sample are varied during a sweep. Electronic filtering is provided to separate low frequency signals, corresponding to structural details of the sample, and high frequency signatures, corresponding to localized defects on the sample. |
| FILED | Thursday, April 21, 2022 |
| APPL NO | 17/726023 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/8851 (20130101) Original (OR) Class G01N 2021/8848 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220317081 | Zhe et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Jiang Zhe (Copley, Ohio); Dian Jiao (Akron, Ohio); Aaron Urban (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jiang Zhe (Copley, Ohio); Dian Jiao (Akron, Ohio); Aaron Urban (Cleveland, Ohio) |
| ABSTRACT | A fluid property sensing array includes a first sensor including a first electrode assembly and a first sensing layer at least partially coating the first electrode assembly, the first sensor having a first response to a property of the fluid; and a second sensor including a second electrode assembly and a second sensing layer at least partially coating the second electrode assembly, the second sensor having a second response to the property of the fluid. The array can include a third sensor including a third electrode assembly and a third sensing layer at least partially coating the third electrode assembly, the third sensor having a third response to the property of the fluid. The first sensing layer, the second sensing layer, and the third sensing layer can be compositionally different, such that the first response, the second response, and the third response to the property of the fluid are different. |
| FILED | Friday, January 28, 2022 |
| APPL NO | 17/587101 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/302 (20130101) Original (OR) Class G01N 33/2847 (20130101) G01N 33/2876 (20130101) Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/08 (20130101) G06N 3/063 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220317335 | Shalaev et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vladimir M. Shalaev (West Lafayette, Indiana); Alexandra Boltasseva (West Lafayette, Indiana); Alexei Lagutchev (West Lafayette, Indiana); Alexander Senichev (West Lafayette, Indiana); Zachariah O. Martin (West Lafayette, Indiana); Demid Sychev (West Lafayette, Indiana); Samuel Peana (West Lafayette, Indiana); Xiaohui Xu (Lafayette, Indiana) |
| ABSTRACT | A photon emitter includes a multi-layer film. The multi-layer film includes a first material layer and a second material layer, and the multi-layer film includes an interface surface between the first and second material layers. The first material layer includes silicon nitride. The multi-layer film is formed by positioning the silicon nitride over the second material layer and energetically activating the combination of the first material layer and the second material layer. The interface surface is operable to emit single photons. |
| FILED | Tuesday, April 05, 2022 |
| APPL NO | 17/713850 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) Optical Elements, Systems, or Apparatus G02B 1/002 (20130101) Original (OR) Class G02B 5/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220317381 | SEOK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tae Joon SEOK (Berkeley, California); Ming Chiang A WU (Moraga, California) |
| ABSTRACT | A large-scale single-photonics-based optical switching system that occupies an area larger than the maximum area of a standard step-and-repeat lithography reticle is disclosed. The system includes a plurality of identical switch blocks, each of is formed in a different reticle field that no larger than the maximum reticle size. Bus waveguides of laterally adjacent switch blocks are stitched together at lateral interfaces that include a second arrangement of waveguide ports that is common to all lateral interfaces. Bus waveguides of vertically adjacent switch blocks are stitched together at vertical interfaces that include a first arrangement of waveguide ports that is common to all vertical interfaces. In some embodiments, the lateral and vertical interfaces include waveguide ports having waveguide coupling regions that are configured to mitigate optical loss due to stitching error. |
| FILED | Monday, June 13, 2022 |
| APPL NO | 17/839173 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/3508 (20130101) G02B 6/3546 (20130101) Original (OR) Class G02B 6/12007 (20130101) G02B 6/29344 (20130101) G02B 2006/12145 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220317485 | Partee et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Syght, Inc. (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles C. Partee (Golden, Colorado); Kevin D. McKinstry (Westminster, Colorado); Michael G. Machado (Honokaa, Hawaii) |
| ABSTRACT | A spatial light modulator system includes a concentration layer including an array of optical concentrators, such that each concentrator concentrates a portion of an input light beam. A modulation layer includes an array of light modulators each in optical communication with one of the optical concentrators for modulating the portion of the input light beam. The light modulators are spaced apart from one another in the modulation layer to form gaps between adjacent ones of the light modulators. A coil of each light modulator can surround a Faraday element or core containing a Faraday material to control a magnetic state of a Faraday material responsive to control signals. |
| FILED | Monday, June 13, 2022 |
| APPL NO | 17/838742 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 3/0056 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/09 (20130101) Original (OR) Class G02F 1/092 (20130101) G02F 1/095 (20130101) G02F 2203/07 (20130101) G02F 2203/12 (20130101) Pictorial Communication, e.g Television H04N 9/3167 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220320357 | Druffel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Bert Thin Films, LLC (Louisville, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thad Druffel (Louisville, Kentucky); Ruvini Dharmadasa (Louisville, Kentucky) |
| ABSTRACT | A paste (32) for use in metallization of a solar cell (12) includes an organic vehicle (44) and a mixture of copper-containing particles (46), metal-oxide-containing nanoparticles (50), and secondary oxide particles (52) different from the metal-oxide-containing nanoparticles (50). The secondary oxide particles (52) include particles (42) of a metal oxide and a metal of the metal oxide capable of reducing at least some of the metal-oxide-containing nanoparticles (50) to metal when heated. The organic vehicle (44) is capable of reducing the metal oxide of the secondary oxide particles (52) upon decomposition of the organic vehicle (44). A paste (32) includes a mixture of particles (42) including metallic copper particles (46), nanoparticles (50), and metal oxide particles (52) in the organic vehicle (44). The nanoparticles (50) include at least one oxide of nickel, copper, cobalt, manganese, and lead. The metal oxide of the metal oxide particles (52) has a more negative Gibbs Free Energy of Formation than a metal oxide of the at least one oxide of the nanoparticles (50). |
| FILED | Friday, June 10, 2022 |
| APPL NO | 17/837087 |
| CURRENT CPC | Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/22 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/18 (20130101) H01L 31/0512 (20130101) Original (OR) Class H01L 31/02245 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220320526 | SONG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | West Virginia University (Morgantown, West Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xueyan SONG (Pittsburgh, Pennsylvania); Yun CHEN (Pittsburgh, Pennsylvania); Kirk GERDES (Morgantown, West Virginia) |
| ABSTRACT | In one aspect, the disclosure relates to method of forming an electrocatalyst structure on an electrode, comprising depositing a first layer on the electrode using atomic layer deposition (ALD), wherein the first layer comprises a plurality of discrete nanoparticles of a first electrocatalyst, and depositing one or more of a second layer on the first layer and the electrode using ALD, wherein the one or more second layer comprises a second electrocatalyst, wherein the first layer and the one or more second layers, collectively, form a multi-layer electrocatalyst structure on the electrode. Also disclosed are electrodes having a multi-layer electrocatalyst structure. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure. |
| FILED | Thursday, March 24, 2022 |
| APPL NO | 17/703977 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/06 (20130101) C23C 16/406 (20130101) C23C 16/45555 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/8621 (20130101) H01M 4/8657 (20130101) Original (OR) Class H01M 4/8867 (20130101) H01M 4/9025 (20130101) H01M 4/9058 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220321393 | MOHAMMADNEZHAD et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hossein MOHAMMADNEZHAD (Irvine, California); Huan WANG (Irvine, California); Payam HEYDARI (Irvine, California) |
| ABSTRACT | Aspects of quadrature phase shift keying for quadrature amplitude modulation are described. In some examples, quadrature phase shift keying signals are generated using quadrature phase shift keying modulators. The quadrature phase shift keying signals are combined in a combiner circuit to generate a quadrature amplitude modulation signal for wireless transmission. |
| FILED | Wednesday, June 17, 2020 |
| APPL NO | 17/597261 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 27/361 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20220313610 | Castor |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Aphios Corporation (Wobum, Massachusetts) |
| ASSIGNEE(S) | Aphios Corporatio (Woburn, Massachusetts) |
| INVENTOR(S) | Trevor Percival Castor (Arlington, Massachusetts) |
| ABSTRACT | This invention relates to methods for and products from precision manufacturing targeted nanoencapsulated drugs in a microgravity environment utilizing green, environmental-friendly SuperFluids™. Based on these methods, nanoparticles formulation of molecules such as, but not limited to, Bryostatin-1 and other Bryoids, manufactured and lyophilized in a gravity-based environment, will be smaller and more uniform with a higher surface area to volume ratio, approaching ‘picometer dimensions’ in a microgravity environment. Once frozen in Space, these enhanced nanoparticles, ‘picoparticles’ approaching ‘picometer dimensions’ will also find utility on Earth to treat ‘orphan’ and chronic diseases such as cancer, HIV and Alzheimer's disease. The methods feature SuperFluids™ which are supercritical, critical and near-critical fluids with and without polar cosolvents. |
| FILED | Sunday, April 04, 2021 |
| APPL NO | 17/221831 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1277 (20130101) Original (OR) Class A61K 31/35 (20130101) A61K 47/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220314159 | Zaffetti et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark A. Zaffetti (Suffield, Connecticut); Daniel J. Kehoe (Coventry, Connecticut) |
| ABSTRACT | A swing bed absorption apparatus includes a bed including a bed housing including, an outer surface, an interior chamber, and a flared interior passageway fluidly connecting the interior chamber to an area located outside of the bed. The flared interior passageway includes an opening in the outer surface, a chamber opening at the interior chamber, a first portion located at the opening, the first portion being fluidly connected to the area located outside the bed through the opening, and a flared portion located at the chamber opening, the flared portion being fluidly connected to the interior chamber through the chamber opening. The flared portion connects to the interior chamber at an obtuse angle. |
| FILED | Thursday, April 01, 2021 |
| APPL NO | 17/220074 |
| CURRENT CPC | Separation B01D 53/047 (20130101) B01D 53/0415 (20130101) Original (OR) Class B01D 2257/504 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220315934 | Badran et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts) |
| INVENTOR(S) | Ahmed H. Badran (Cambridge, Massachusetts); Natalie Kolber (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure relates to compositions and methods that enable enhanced monitoring and improvement of heterologous ribosome activity within a host cell. Specifically, the instant disclosure provides a reporter system that allows for improved monitoring of heterologous ribosome activity in a host cell, via engineering of both heterologous rRNA operon sequences and reporter operon sequences. New transgenic organisms harboring heterologous ribosome operons are also provided, as are methods for identifying agents capable of targeting heterologous ribosomes (e.g., ribosomes of pathogenic organisms, optionally selectively as compared to ribosomes of, e.g., commensal organisms) within a host cell. |
| FILED | Tuesday, July 14, 2020 |
| APPL NO | 17/626420 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/67 (20130101) Original (OR) Class C12N 15/1034 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220316001 | ELLINGTON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew ELLINGTON (Austin, Texas); Cheulhee JUNG (Austin, Texas); Sheng CAI (Zhejiang, China PRC); Sanchita BHADRA (Austin, Texas); John N. MILLIGAN (Austin, Texas); Daniel GARRY (Austin, Texas); Raghav SHROFF (Austin, Texas) |
| ABSTRACT | Disclosed are compositions and methods for nucleic acid amplification and detection. Specifically, disclosed herein are compositions and methods that allow for amplification of nucleic acids at a wide variety of temperatures. This includes a polymerase which is thermostable at high temperatures, and a method of amplification that can be conducted at relatively low temperatures. |
| FILED | Wednesday, January 19, 2022 |
| APPL NO | 17/579085 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1252 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/6853 (20130101) Original (OR) Class C12Q 2521/101 (20130101) C12Q 2525/301 (20130101) C12Q 2527/101 (20130101) C12Q 2531/101 (20130101) C12Q 2537/1373 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220316466 | Mitchell et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| INVENTOR(S) | Shane Karl Mitchell (Boulder, Colorado); Eric Lucas Acome (Longmont, Colorado); Christoph Matthias Keplinger (Gerlingen, Germany) |
| ABSTRACT | A pumping system includes a conduit with an inlet region and an outlet region and a first pump coupled with the conduit between the inlet region and the outlet region. The first pump includes a first actuator chamber configured to house at least a first actuator, a first pump chamber aligned along a longitudinal axis of the conduit, wherein the first pump chamber is in fluid communication with the inlet region and the outlet region, and a first flexible diaphragm separating the first actuator chamber from the first pump chamber. Methods for operating the pumping system are also disclosed. |
| FILED | Friday, August 14, 2020 |
| APPL NO | 17/635339 |
| CURRENT CPC | Positive-displacement Machines for Liquids; Pumps F04B 23/04 (20130101) F04B 43/04 (20130101) Original (OR) Class F04B 53/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220316865 | OHANIAN, III et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | LUNA INNOVATIONS INCORPORATED (Roanoke, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Osgar John OHANIAN, III (Blacksburg, Virginia); Matthew Anthony DAVIS (Christiansburg, Virginia) |
| ABSTRACT | An apparatus comprises a flexible filament structure, and a fiber optic sensor with a buffer material that locally bonds the fiber optic sensor to the flexible filament structure to create a bond between the fiber optic sensor and the flexible filament structure to transfer strain from the flexible filament structure to the fiber optic sensor to allow the fiber optic sensor to detect strain on the flexible filament structure while maintaining flexibility in the flexible filament structure. A fiber optic interrogator may be optically coupled to the fiber optic sensor and configured to measure strain. A method comprises embedding a fiber optic sensor with a buffer material in or on a flexible filament structure. Thereafter, the buffer material is activated via heating or curing to locally adhere the fiber optic sensor to the flexible filament structure to create a local bond. The local bond transfers strain from the flexible filament structure to the fiber optic sensor. |
| FILED | Thursday, August 27, 2020 |
| APPL NO | 17/638458 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 11/18 (20130101) Original (OR) Class Measuring Not Specially Adapted for a Specific Variable; Arrangements for Measuring Two or More Variables Not Covered in a Single Other Subclass; Tariff Metering Apparatus; Measuring or Testing Not Otherwise Provided for G01D 5/35374 (20130101) Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/246 (20130101) Optical Elements, Systems, or Apparatus G02B 6/4298 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220318673 | HARRIVEL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA (WASHINGTON, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ANGELA R. HARRIVEL (POQUOSON, Virginia); CHAD L. STEPHENS (POQUOSON, Virginia); KELLIE D. KENNEDY (POQUOSON, Virginia); ALAN T. POPE (POQUOSON, Virginia) |
| ABSTRACT | Aspects of the present disclosure are directed to devices, systems, and methods for optimized integration of a human operator with a machine for safe and efficient operation. Accordingly, aspects of the present disclosure are directed to systems, methods, and devices which evaluate and determine a cognitive state of an operator, and allocate tasks to either the machine and/or operator based on the cognitive state of the operator, among other factors. |
| FILED | Tuesday, May 04, 2021 |
| APPL NO | 17/307639 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/18 (20130101) A61B 5/7264 (20130101) Card, Board, or Roulette Games; Indoor Games Using Small Moving Playing Bodies; Video Games; Games Not Otherwise Provided for A63F 13/21 (20140901) A63F 13/42 (20140902) A63F 13/67 (20140902) A63F 13/212 (20140902) Electric Digital Data Processing G06F 3/011 (20130101) G06F 3/015 (20130101) Computer Systems Based on Specific Computational Models G06N 5/04 (20130101) G06N 20/00 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220321056 | Murphey et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Opterus Research and Development, Inc. (Fort Collins, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas W. Murphey (Fort Collins, Colorado); Edward Smutney (Boulder, Colorado); Daniel Hunt (Fort Collins, Colorado) |
| ABSTRACT | A retractable mast solar array includes a collapsible boom extensible by a boom deployer. At least one foldable upper arm assembly is coupled to the collapsible boom. At least one foldable lower arm assembly coupled to the collapsible boom. A foldable solar array includes two or more columns of blanket elements, each column of blanket elements is affixed at one end to the at least one foldable upper arm assembly and at an opposite end to the at least one foldable lower arm assembly. In a stowed state, the two or more columns of blanket elements are stowed folded in either or both of the at least one foldable upper arm assembly or the at least one foldable lower arm assembly, and in a deployed state, the two or more columns of blanket elements are unfolded to a deployed solar array. |
| FILED | Wednesday, March 30, 2022 |
| APPL NO | 17/657245 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/44 (20130101) B64G 1/222 (20130101) Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 10/40 (20141201) H02S 30/20 (20141201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220321391 | JAMAL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF SOUTH CAROLINA (Columbia, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | HOSSEINALI JAMAL (Columbia, South Carolina); DAVID W. MATOLAK (Chapin, South Carolina) |
| ABSTRACT | Conventional filter bank multi-carrier (FBMC) wireless communication systems offer superior spectral properties compared to the cyclic-prefix orthogonal frequency-division multiplexing (CP-OFDM) approach, at the cost of an inherent shortcoming in dispersive channels called intrinsic imaginary interference. In this disclosure the DP-FBMC system was disclosed. A DP-FBMC based communication system uses two orthogonal polarizations for wireless communication systems: dual-polarization FBMC (DP-FBMC). The system significantly suppresses FBMC intrinsic interference. For the disclosed DP-FBMC all the multicarrier techniques used in CP-OFDM systems for channel equalization etc., are applicable without using complex processing methods that are required for conventional FBMC. Disclosed DP-FBMC also is more robust in multipath fading channels, and also to receiver carrier frequency offset (CFO) and Timing offset (TO). In the disclosed DP-FBMC system, three different structures may be used based on different multiplexing techniques. |
| FILED | Thursday, March 21, 2019 |
| APPL NO | 16/360359 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 27/2654 (20210101) H04L 27/26412 (20210101) H04L 27/26416 (20210101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220322022 | RAFAELOF et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA (WASHINGTON, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | MENACHEM RAFAELOF (YORKTOWN, Virginia); KYLE WENDLING (HENRICO, Virginia); ANDREW W. CHRISTIAN (HAMPTON, Virginia) |
| ABSTRACT | A statistical audibility prediction (SAP) method for predicting the audibility of a signal over time at a listening location, the signal from a signal source in the presence of a concurrent masking sound or masker from a masker source. The method includes receiving, via a processor over a plurality of auditory channels, a specific loudness of the signal and masker at the listening location. The method includes calculating for each auditory channel a standard deviation of a distribution of the specific loudness of the signal and masker, and calculating, via the processor, corresponding channel-specific detectability indices (d′t,i) for each auditory channel as a function of their standard deviations. The corresponding channel-specific detectability indices are then summed to produce a total detectability index (d′t), which may be output as an electronic signal that indicates the predicted audibility vs. time, e.g., to a downstream process and/or system or offline. |
| FILED | Wednesday, March 30, 2022 |
| APPL NO | 17/708575 |
| CURRENT CPC | Sound-producing Devices; Methods or Devices for Protecting Against, or for Damping, Noise or Other Acoustic Waves in General; Acoustics Not Otherwise Provided for G10K 11/1752 (20200501) Stereophonic Systems H04S 3/008 (20130101) H04S 7/303 (20130101) Original (OR) Class H04S 2400/01 (20130101) H04S 2400/13 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220322259 | Zhuge et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Crystal Instruments Corporation (Santa Clara, California) |
| ASSIGNEE(S) | Crystal Instruments Corporation (Santa Clara, California) |
| INVENTOR(S) | James Q. Zhuge (Palo Alto, California); Zhengge Tang (San Jose, California) |
| ABSTRACT | A distributed data acquisition system comprising multiple, physically unconnected, data acquisition units that can be in wireless communication with a remote host, timestamps measurement data with sub-microsecond time base accuracy of sampling clock relative to an absolute timeframe. Each unit has a GPS receiver for deriving an absolute time. An analog-to-digital converter samples measurement data using a sampling clock. A hardware logic circuit, such as a field programmable gate array, associates batches of the measurement data with corresponding timestamps representing the current absolute time. A time offset bias may be compensated by a comparison of timestamps with nominal time based on start time and nominal sampling rate. Additionally, the sampling clock may be synchronized using time pulses from the GPS receiver. An initial start of ADC sampling by all data acquisition units may be also synchronized. |
| FILED | Thursday, October 14, 2021 |
| APPL NO | 17/501293 |
| CURRENT CPC | Automatic Control, Starting, Synchronisation, or Stabilisation of Generators of Electronic Oscillations or Pulses H03L 7/24 (20130101) Coding; Decoding; Code Conversion in General H03M 1/0624 (20130101) H03M 1/1255 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 7/0087 (20130101) Wireless Communication Networks H04W 56/002 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220322260 | Zhuge et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Crystal Instruments Corporation (Santa Clara, California) |
| ASSIGNEE(S) | Crystal Instruments Corporation (Santa Clara, California) |
| INVENTOR(S) | James Q. Zhuge (Palo Alto, California); Zhengge Tang (San Jose, California) |
| ABSTRACT | A method uses a distributed data acquisition system with multiple, physically unconnected, data acquisition units, that can be in wireless communication with a remote host, to timestamp measurement data with sub-microsecond time base accuracy of sampling clock relative to an absolute timeframe. A current absolute time is derived from messages received from a satellite radio beacon positioning system (GPS). Measurement data is sampled by each unit at a specified sampling rate. Using hardware logic, batches of sampled data are associated with corresponding timestamps representing the absolute time at which the data was sampled. Data and timestamps may be transmitted to the host. A time offset bias is compensated by comparing timestamps against a nominal time based on start time and nominal sampling rate. The sampling clock rate may be disciplined using time pulses from the GPS receiver. An initial start of data sampling by all units can also be synchronized. |
| FILED | Thursday, October 14, 2021 |
| APPL NO | 17/501302 |
| CURRENT CPC | Pulse Technique H03K 19/00323 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 7/0087 (20130101) Wireless Communication Networks H04W 56/002 (20130101) Original (OR) Class H04W 56/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20220318527 | Ashaari et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shahpour Ashaari (Bethesda, Maryland); David C. Lin (Falls Church, Virginia); Seth S. Vasa (Olney, Maryland); Scott R. Bombaugh (Burke, Virginia); Mario Andre Salisbury (Miami, Florida); Thomas Jay Graham (Chantilly, Virginia); Erich Joseph Petre (Gainesville, Virginia) |
| ABSTRACT | Systems and methods of identifying wearable tags or other items within a facility. The location of the identifiable item can be calculated by the system and used to improve the efficiency of the facility or to dispatch emergency help or maintenance to the location of the badge. |
| FILED | Friday, April 22, 2022 |
| APPL NO | 17/660377 |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/4183 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 7/10099 (20130101) Original (OR) Class G06K 7/10475 (20130101) G06K 19/07758 (20130101) Wireless Communication Networks H04W 4/021 (20130101) H04W 4/33 (20180201) H04W 4/35 (20180201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220319262 | Tartal et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William Albert Tartal (Baltimore, Maryland); Gabriel Michael Yessin (Vienna, Virginia) |
| ABSTRACT | Systems, devices, and methods of locking a lockable volume. The lock may comprise a bolt and a slider. The slider moves linearly to move the bolt in position to engage a securement feature. The engagement of the bolt with the securement feature secures the securement feature, thereby locking the door to which the securement feature is attached. |
| FILED | Monday, June 20, 2022 |
| APPL NO | 17/807782 |
| CURRENT CPC | Locks; Accessories Therefor; Handcuffs E05B 17/0037 (20130101) E05B 47/026 (20130101) E05B 65/025 (20130101) E05B 77/48 (20130101) Time or Attendance Registers; Registering or Indicating the Working of Machines; Generating Random Numbers; Voting or Lottery Apparatus; Arrangements, Systems or Apparatus for Checking Not Provided for Elsewhere G07C 9/00912 (20130101) Original (OR) Class G07C 9/00944 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220319297 | MCCULLOUGH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES POSTAL SERVICE (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mitchell Obrian MCCULLOUGH (Nashville, Tennessee); Yavar MISAGHI BONABI (Portland, Oregon); Ryan J. HRAPSKY (Arlington, Virginia) |
| ABSTRACT | A method, an obstruction detecting device, and a non-transitory machine-readable storage medium are provided for detecting an object obstructing access to a feature of a building. A distance sensor connected with an obstruction detecting device emits a signal. The distance sensor receives a reflection of the signal from an object. A microcontroller of the obstruction detecting device, which is connected to the distance sensor, determines a distance from the distance sensor to the object based on an amount of time between the emitting of the signal and the receiving of the reflection of the signal. When the determined distance is less than a threshold distance, indicating that the reflecting object is obstructing access to the feature, the obstruction detecting device provides an alarm. |
| FILED | Tuesday, March 22, 2022 |
| APPL NO | 17/701218 |
| CURRENT CPC | Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 3/10 (20130101) G08B 21/18 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 20220317109 | Arnold et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Terence S Arnold (Washington Grove, Maryland); Chandni Balachandran (McLean, Virginia); Jose F Munoz (Ellicott City, Maryland) |
| ASSIGNEE(S) | The United States Department of Transportation / Federal Highway Administration (Washington, District of Columbia) |
| INVENTOR(S) | Terence S Arnold (Washington Grove, Maryland); Chandni Balachandran (McLean, Virginia); Jose F Munoz (Ellicott City, Maryland) |
| ABSTRACT | Chemical test methods for evaluating the alkali-silica reactivity (ASR) of an aggregate or an aggregate within a particular concrete job mix design by exposing the aggregate to a simplified system with the same or simulated long-term pore solution conditions is provided. ASR is a chemical reaction occurring between alkaline hydroxides within cement paste and certain types of amorphous silica found in mineral aggregates. Causing an accumulation of internal pressure within concrete structures due to the formation of a hygroscopic gel through the absorption of water, ASR leads to expansion and cracking of concrete. The present test method determines the reactivity index (RI) of a given aggregate, or an aggregate as it is to be used in a proposed concrete job mix design by determining the average concentrations of calcium, aluminum, and silicon across multiple tested samples, wherein the RI is the ratio of the concentrations of silicon to that of aluminum and calcium combined. |
| FILED | Friday, December 04, 2020 |
| APPL NO | 17/112090 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 40/0032 (20130101) C04B 40/0082 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/383 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220318701 | Sadri et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arif Mohaimin Sadri (Miami, Florida); Md Ashraf Ahmed (Miami, Florida) |
| ASSIGNEE(S) | The Florida International University Board of Trustees (Miami, Florida) |
| INVENTOR(S) | Arif Mohaimin Sadri (Miami, Florida); Md Ashraf Ahmed (Miami, Florida) |
| ABSTRACT | Systems, methods, and frameworks are provided for analyzing topological credentials of a physical network or infrastructure using network science principles and identifying the most influential physical locations within the physical network. The vulnerability and resilience of the physical network can be assessed based on network science principles and/or graph theory to identify the most central physical components to assist with decision making for operation, maintenance, repair, and/or construction within the physical network. |
| FILED | Tuesday, March 30, 2021 |
| APPL NO | 17/217547 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/0635 (20130101) G06Q 10/0637 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20220313423 | Flanagan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kent Flanagan (Charleston, South Carolina); Bethany Baldwin (Charleston, South Carolina); Nicole Beitenman (Charleston, South Carolina) |
| ABSTRACT | An ear stent can be inserted into a collapsing ear canal to improve conductive hearing. The ear stent can be configured for insertion into an ear canal of a user. The ear stent can have a longitudinal axis. The ear stent can comprise an insertional portion that extends along the longitudinal axis between an insertional end and an outer end. The insertional portion can be configured to be inserted into the ear canal. The insertional portion can define a channel therethrough from the insertional end to the outer end. A flange portion can extend outwardly from the insertional portion at the outer end of the insertional portion. |
| FILED | Friday, April 01, 2022 |
| APPL NO | 17/711782 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/18 (20130101) Original (OR) Class A61F 2002/183 (20130101) A61F 2230/0073 (20130101) A61F 2250/0037 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220313632 | Sun et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government as Represented by the Department of Veterans Affairs (Washington, Delaware); University of Pittsburgh-of the Commonwealth of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dandan Sun (Pittsburgh, Pennsylvania); Mohammad Iqbal Hossain Bhuiyan (Pittsburgh, Pennsylvania) |
| ABSTRACT | The present disclosure is concerned with substituted N-(5-chloro-4-((4-chlorophenyl)(cyano)methyl)-2-methylphenyl)benzamide compounds, and methods of treating and/or preventing neurodegenerative or neurocognitive disorders including, but not limited to, Alzheimer's disease, cerebral autosomal dominant arteriopathy with sub-cortical infarcts and leukoencephalopathy (CADASIL), Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis (ALS/Lou Gehrig's disease), Multiple Sclerosis, spinal muscular atrophy, spinal and bulbar muscular atrophy, familial spastic paraparesis, Machado Joseph disease, Friedreich's ataxia, Lewy body disease, and dementia (e.g., vascular dementia, Lewy body dementia, frontotemporal dementia, mixed dementia, dementia induced by Alzheimer's disease or Parkinson's disease). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| FILED | Friday, March 25, 2022 |
| APPL NO | 17/704789 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/167 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Non-Profit Organization (NPO)
| US 20220314010 | Halperin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Henry Halperin (Baltimore, Maryland); Ehud J. Schmidt (Boston, Massachusetts); Ronald D. Watkins (Stanford, California); Harikrishna Tandri (Ellicott City, Maryland); David Hunter (Baltimore, Maryland); Leslie Tung (Columbia, Maryland); Ronald D. Berger (Baltimore, Maryland) |
| ABSTRACT | A magnetic-resonance-imaging-compatible (MRI-compatible) cardiac defibrillator includes: a defibrillator generator; first and second electric wires, each being electrically connected to said defibrillator generator; first and second defibrillation pads, each being electrically connected to a respective one of said first and second electric wires; and a low pass filter electrically connected between said defibrillator generator and said first and second electric wires to prevent a noise in an MRI image caused by a radiofrequency interference from the defibrillator as well as protect a patient and the defibrillator from MRI radiofrequency imaging signals, wherein said low pass filter has a cutoff frequency set such that differential mode noise at an MRI Larmor frequency is in an attenuated band while a system-test signal by said defibrillator generator is in a pass band of said low pass filter. |
| FILED | Monday, November 15, 2021 |
| APPL NO | 17/526254 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/361 (20210101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/3904 (20170801) Original (OR) Class A61N 1/3925 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220320357 | Druffel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Bert Thin Films, LLC (Louisville, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thad Druffel (Louisville, Kentucky); Ruvini Dharmadasa (Louisville, Kentucky) |
| ABSTRACT | A paste (32) for use in metallization of a solar cell (12) includes an organic vehicle (44) and a mixture of copper-containing particles (46), metal-oxide-containing nanoparticles (50), and secondary oxide particles (52) different from the metal-oxide-containing nanoparticles (50). The secondary oxide particles (52) include particles (42) of a metal oxide and a metal of the metal oxide capable of reducing at least some of the metal-oxide-containing nanoparticles (50) to metal when heated. The organic vehicle (44) is capable of reducing the metal oxide of the secondary oxide particles (52) upon decomposition of the organic vehicle (44). A paste (32) includes a mixture of particles (42) including metallic copper particles (46), nanoparticles (50), and metal oxide particles (52) in the organic vehicle (44). The nanoparticles (50) include at least one oxide of nickel, copper, cobalt, manganese, and lead. The metal oxide of the metal oxide particles (52) has a more negative Gibbs Free Energy of Formation than a metal oxide of the at least one oxide of the nanoparticles (50). |
| FILED | Friday, June 10, 2022 |
| APPL NO | 17/837087 |
| CURRENT CPC | Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/22 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/18 (20130101) H01L 31/0512 (20130101) Original (OR) Class H01L 31/02245 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Classified Government Agency
| US 20220317315 | Cooper et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BAE SYSTEMS Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| ASSIGNEE(S) | BAE SYSTEMS Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| INVENTOR(S) | David M. Cooper (New York, New York); Wayne W. Altrichter (Chatham, New Jersey); Aaron W. Bennett (Merrimack, New Hampshire); Matthew J. Sherman (Succasunna, New Jersey) |
| ABSTRACT | The system and method for position, navigation, and timing and more particularly to a system that is time and/or position independent and capable of autonomous transition from GPS to non-GPS navigation. The integrated position, navigation, and timing system uses primary and secondary navigation sensors and primary and secondary navigation measurement sources with a common time reference architecture, an integrated “dual-grid” navigation module, an integrated “dual-grid” navigation Kalman filter, and an integrated “dual-grid” navigation source selection module to provide both geodetic and relative grid timing and/or location among members of a network of platforms, particularly in GPS denied or degraded environments. |
| FILED | Monday, April 05, 2021 |
| APPL NO | 17/222049 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/20 (20130101) G01C 21/165 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 19/47 (20130101) Original (OR) Class Secret Communication; Jamming of Communication H04K 3/25 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20220315628 | Tullman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jennifer A. Tullman (Germantown, Maryland); Zvi Kelman (Gaithersburg, Maryland); John P. Marino (Silver Spring, Maryland) |
| ABSTRACT | An amino acid-specific binder selectively binds to a binding amino acid. A binder complex selectively identifies the binding amino acid and includes an adjunct attached to the amino acid-specific binder. The adjunct includes a taggant, protein, substrate, or chemical modifier. Selectively identifying an N-terminal amino acid includes anchoring a C-terminal end; contacting an N-terminal amino acid of the anchored analyte with the binder complex; selectively binding when the N-terminal amino acid includes the binding amino acid; producing, by the taggant of the tagged complex, a taggant signal; detecting the taggant signal; and identifying the N-terminal amino acid based on the taggant signal. |
| FILED | Friday, June 10, 2022 |
| APPL NO | 17/837082 |
| CURRENT CPC | Peptides C07K 1/13 (20130101) C07K 14/195 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/582 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20220318785 | Lim et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Jason Lim (Alexandria, Virginia); Daniel Boyd (Arlington, Virginia); Chang Ellison (Arlington, Virginia); William Washington (North Potomac, Maryland); Khailee Marischuk (Smyrna, Georgia) |
| ABSTRACT | A provider system is connected to one or more readers corresponding to one or more access points. A secure local connection is established between the user device and the provider system via one reader. The provider system receives from the user device a request for user access via one access point corresponding to the one reader, the provider system sends to the user device a request for identification information of the user, and the user device sends user information associated with a first mobile identification credential (MIC) which the user device received from an authorizing party system (APS), the user having consented to release the user information to the provider system, and the user information having been verified. The provider system uses the verified user information associated with the first MIC to verify or not verify the identity of the user before granting or denying the request to the user. |
| FILED | Tuesday, June 07, 2022 |
| APPL NO | 17/834577 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 20/326 (20200501) G06Q 20/347 (20130101) Original (OR) Class G06Q 20/3224 (20130101) G06Q 20/3226 (20130101) G06Q 20/3674 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Justice (DOJ)
| US 20220315996 | Tan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ANDE Corporation (Waltham, Massachusetts) |
| ASSIGNEE(S) | ANDE CORPORATION (WALTHAM, Massachusetts) |
| INVENTOR(S) | Eugene Tan (Arlington, Massachusetts); Richard F. Selden (Lincoln, Massachusetts); Rosemary S. Turingan (Stoneham, Massachusetts) |
| ABSTRACT | Described herein are methods and devices for nucleic acid quantification and, in particular, to microfluidic methods and devices for nucleic acid quantification. In certain embodiments methods of quantifying a target nucleic acid without the need for amplification are provided. The methods involve, in some embodiments, allowing a binding agent to become immobilized with respect to the target nucleic acid. In some cases, the binding agent comprises a signaling moiety that can be used to quantify the amount of target nucleic acid. In another aspect, the quantification can be carried out rapidly. For example, in certain embodiments, the quantification can be completed within 5 minutes. In yet another aspect, samples containing a low amount of target nucleic acid can be quantified. For instance, in some cases, samples containing less than 100 nanograms per microliter may be quantified. Also described are devices and kits for performing such methods, or the like. |
| FILED | Thursday, June 09, 2022 |
| APPL NO | 17/836825 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5027 (20130101) B01L 3/502715 (20130101) B01L 7/52 (20130101) B01L 2300/168 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1017 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6816 (20130101) C12Q 1/6818 (20130101) C12Q 1/6825 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2201/06113 (20130101) Optical Elements, Systems, or Apparatus G02B 27/10 (20130101) Technical Subjects Covered by Former US Classification Y10T 436/143333 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of the Interior (DOI)
| US 20220313730 | ROTH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Fred Hutchinson Cancer Center (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark B. ROTH (Seattle, Washington); Michael L. MORRISON (Seattle, Washington); Akiko IWATA (Seattle, Washington) |
| ABSTRACT | The present invention relates to the use of halogen compounds, including iodide, and chalcogenide compounds, including iodide, sulfide and selenide, to treat and prevent diseases and injuries. The present invention further relates to compositions comprising a halogen compound and/or a chalcogenide compound, including pharmaceutical compositions, as well as methods of manufacturing such compounds and administering such compositions to subjects in need thereof. |
| FILED | Thursday, December 30, 2021 |
| APPL NO | 17/565885 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 33/00 (20130101) A61K 33/04 (20130101) A61K 33/16 (20130101) A61K 33/18 (20130101) Original (OR) Class A61K 38/063 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Reconnaissance Office (NRO)
| US 20220321057 | Mazor et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Roccor, LLC (Longmont, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bryan Mazor (Denver, Colorado); Thomas Jeffrey Harvey (Nederland, Colorado); Toby Harvey (Enoch, Utah); Zachary McConnel (Longmont, Colorado); Maegan Gilmour (Broomfield, Colorado) |
| ABSTRACT | Distributed flexible membrane backing systems, devices, and methods are provided in accordance with various embodiments. Some embodiments utilize distributed backing structures in lieu of a central boom technology or rigid panel structure. Disaggregating the structural component generally allows the structure mass and volume to be distributed more efficiently across the backside of the flexible membrane, such as a photovoltaic membrane. This distribution generally enables an increased number of structural support points (within the deployed flexible membrane), which may increase the performance of the flexible membrane. Some embodiments interface the structure and the membranes throughout the entire surface of the deployed membrane. The distribution of structure may allow more efficient stowage of the deployable structure. This distributed backing structures may allow for increased structural depth to be achieved, effectively creating a deep deployed truss on the backside of the deployed membrane, such as a solar array or antenna. |
| FILED | Monday, April 04, 2022 |
| APPL NO | 17/712569 |
| CURRENT CPC | Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 30/20 (20141201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20220320357 | Druffel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Bert Thin Films, LLC (Louisville, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thad Druffel (Louisville, Kentucky); Ruvini Dharmadasa (Louisville, Kentucky) |
| ABSTRACT | A paste (32) for use in metallization of a solar cell (12) includes an organic vehicle (44) and a mixture of copper-containing particles (46), metal-oxide-containing nanoparticles (50), and secondary oxide particles (52) different from the metal-oxide-containing nanoparticles (50). The secondary oxide particles (52) include particles (42) of a metal oxide and a metal of the metal oxide capable of reducing at least some of the metal-oxide-containing nanoparticles (50) to metal when heated. The organic vehicle (44) is capable of reducing the metal oxide of the secondary oxide particles (52) upon decomposition of the organic vehicle (44). A paste (32) includes a mixture of particles (42) including metallic copper particles (46), nanoparticles (50), and metal oxide particles (52) in the organic vehicle (44). The nanoparticles (50) include at least one oxide of nickel, copper, cobalt, manganese, and lead. The metal oxide of the metal oxide particles (52) has a more negative Gibbs Free Energy of Formation than a metal oxide of the at least one oxide of the nanoparticles (50). |
| FILED | Friday, June 10, 2022 |
| APPL NO | 17/837087 |
| CURRENT CPC | Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/22 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/18 (20130101) H01L 31/0512 (20130101) Original (OR) Class H01L 31/02245 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
U.S. State Government
| US 20220317328 | Barajas-Olalde et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Energy and Enveronmental Research Center Foundation (Grand Forks, North Dakota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | César Barajas-Olalde (Grand Forks, North Dakota); Saurabh Ajit Chimote (Grand Forks, North Dakota); Jordan Michael Krueger (Grand Forks, North Dakota); Donald C. Adams, III (Grand Forks, North Dakota) |
| ABSTRACT | Methods, systems, and computer programs are presented for detecting buried pipelines and spills. One method includes operations for programming a drone to fly over a geographical area, and for capturing, during a flight of the drone, geophysical data with geophysical equipment in the drone. Further, the method includes capturing, during the flight of the drone, images with a camera in the drone. A machine-learning (ML) model is utilized to identify locations of buried pipes and spills based on the captured geophysical data and the captured images. Further, the method includes presenting the identified locations of the buried pipes and spills in a map of the geographical area. |
| FILED | Wednesday, March 30, 2022 |
| APPL NO | 17/657205 |
| CURRENT CPC | Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags G01V 3/16 (20130101) G01V 3/38 (20130101) Original (OR) Class G01V 3/081 (20130101) G01V 11/00 (20130101) Image Data Processing or Generation, in General G06T 7/70 (20170101) G06T 2200/24 (20130101) G06T 2207/10032 (20130101) G06T 2207/20081 (20130101) Image or Video Recognition or Understanding G06V 10/774 (20220101) G06V 20/17 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, October 06, 2022.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20221006.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page