FedInvent™ Patent Applications
Application Details for Thursday, October 13, 2022
This page was updated on Friday, October 14, 2022 at 01:24 AM GMT
Department of Health and Human Services (HHS)
| US 20220322668 | Ghiladi et al. |
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| FUNDED BY |
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| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Reza Arman Ghiladi (Raleigh, North Carolina); Richard John Spontak (Raleigh, North Carolina); Frank Scholle (Raleigh, North Carolina) |
| ABSTRACT | In one aspect, the disclosure relates to antimicrobial compositions containing a photosensitizer, a crosslinkable polymer, and a solvent; methods of applying the same to surfaces; methods of using the same to impart antimicrobial properties to surfaces; and surfaces treated using the same. In one aspect, the compositions are effective against a wide range of viruses and bacteria, stable in ambient room lighting, and effective for a period of up to four weeks or longer after a single application. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure. |
| FILED | Monday, April 11, 2022 |
| APPL NO | 17/658663 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 25/10 (20130101) A01N 43/84 (20130101) A01N 43/90 (20130101) Original (OR) Class Biocidal, Pest Repellant, Pest Attractant or Plant Growth Regulatory Activity of Chemical Compounds or Preparations A01P 1/00 (20210801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220322916 | Bagwell et al. |
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| FUNDED BY |
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| APPLICANT(S) | Actuated Medical, Inc. (Bellefonte, Pennsylvania) |
| ASSIGNEE(S) | Actuated Medical, Inc. (Bellefonte, Pennsylvania) |
| INVENTOR(S) | Roger B. Bagwell (Bellefonte, Pennsylvania); Eric J. Hopkins (Bellefonte, Pennsylvania); Casey A. Scruggs (Bellefonte, Pennsylvania); Kevin A. Snook (State College, Pennsylvania) |
| ABSTRACT | A medical instrument having integrated arms extending from a proximal end to a distal end, and a handpiece with actuators to control movement of the arms. The instrument includes an insertion tube having arm channel(s) for receiving an arm therethrough. Each arm includes an engagement member at the distal end of resilient material with a natural non-linear configuration when deployed but deforming when retracted into the arm channel when retracted. Arm channels may be located at different radial distances from one another in the insertion tube so the engagement members may be at radial angles relative to one another when deployed. Arms and engagement members are movable between at least a first position and second position relative to one another by rotation and/or translational motion of the corresponding actuator, to contact tissue or deflect a tool extended through the working channel of the endoscope. |
| FILED | Tuesday, June 14, 2022 |
| APPL NO | 17/839989 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/0014 (20130101) A61B 1/00087 (20130101) Original (OR) Class A61B 1/00094 (20130101) A61B 17/29 (20130101) A61B 2017/00818 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220322941 | JAVITT et al. |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
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| INVENTOR(S) | DANIEL JAVITT (Fort Lee, New Jersey); JOAN PRUDIC (New York, New York); STEFAN ROWNY (New York, New York); MARTA MORENO (Hopewell Junction, New York) |
| ABSTRACT | An exemplary system, method, and computer-accessible medium for determining a position or a characteristic of a target(s) for a transcranial magnetic stimulation (TMS) treatment of a patient(s) can be provided, which can include, for example, receiving imaging information of a portion(s) of a head of the patient(s), and determining the position or the characteristic of the target(s) for the TMS treatment of the patient(s) based on the imaging information. The imaging information can be magnetic resonance imaging information. The imaging information can include information regarding a brain and a skull of the patient(s). The position or the characteristic of the target(s) can be determined by identifying (i) the skull, and (ii) a parcel in a section(s) of a brain of the patient(s). The parcel can a dorsolateral prefrontal cortex (DLPFC) parcel. The DLPFC parcel can be identified using a parcellation procedure, which can be a human connectome pipeline procedure |
| FILED | Monday, April 25, 2022 |
| APPL NO | 17/728526 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0036 (20180801) A61B 5/0042 (20130101) Original (OR) Class A61B 5/055 (20130101) A61B 5/165 (20130101) A61B 5/167 (20130101) A61B 5/4076 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 2/006 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/30 (20180101) G16H 20/70 (20180101) G16H 30/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220322971 | Meddings et al. |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
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| INVENTOR(S) | Jennifer Meddings (Ann Arbor, Michigan); James A. Ashton-Miller (Ann Arbor, Michigan); Shiyu Wang (Seattle, Washington); Jessica Marie Ameling (Ann Arbor, Michigan); Shuai Xiong (Shanghai City, China PRC) |
| ABSTRACT | A system for real-time monitoring of movement of a person on a mattress includes sensor devices positioned on one or more peripheral surfaces of the mattress and configured to sense motions of the one or more peripheral surfaces. The sensor devices includes at least first and second sensor devices positioned on a first side surface of the mattress. A processing subsystem is configured to receive signals indicative of the sensed motions of the peripheral surface(s) from the sensor devices, determine whether at least the sensed motions to one or more alert conditions, and selectively cause, or not cause, one or more visual and/or audio indicators to be generated based on whether at least the sensed motions correspond to the alert condition(s). |
| FILED | Friday, July 24, 2020 |
| APPL NO | 17/630367 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/742 (20130101) A61B 5/746 (20130101) A61B 5/1114 (20130101) Original (OR) Class A61B 5/1115 (20130101) A61B 5/1116 (20130101) A61B 5/4094 (20130101) A61B 5/6892 (20130101) A61B 5/7405 (20130101) A61B 2562/0219 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220322993 | Frank et al. |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
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| INVENTOR(S) | Loren M. Frank (San Anselmo, California); Anna Gillespie (San Francisco, California) |
| ABSTRACT | Provided are methods and systems of for enhancing or increasing memory performance and/or memory retrieval in a subject using neurofeedback training. Also provided herein are methods and systems for modulating hippocampal replay in a subject using neurofeedback training. Also provided herein are methods and systems for modulating sharp wave ripple (SWR) activity in a subject using neurofeedback training |
| FILED | Thursday, August 13, 2020 |
| APPL NO | 17/633749 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/245 (20210101) A61B 5/291 (20210101) A61B 5/297 (20210101) A61B 5/374 (20210101) A61B 5/375 (20210101) Original (OR) Class Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/36082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220323004 | BALAGURUNATHAN et al. |
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| APPLICANT(S) | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (Tampa, Florida) |
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| INVENTOR(S) | Yoganand BALAGURUNATHAN (Tampa, Florida); Frederick Lundry LOCKE (Lutz, Florida); Erin DEAN (Tampa, Florida) |
| ABSTRACT | An example method for quantitatively predicting a cancer patient's response to immune-based or targeted therapy and methods of treatment are described herein. In one aspect, disclosed herein are methods for assaying a cancer patient's response to immune-based or targeted therapy, comprising: measuring tumor burden, such as, measuring total metabolic tumor volume either manually or automatically, prior to administration of the immune-based or targeted therapy to create a baseline tumor burden; wherein a high baseline tumor burden indicates that the patient will have a decreased, less efficacious, and/or less durable response, response to immune-based or targeted therapy. |
| FILED | Thursday, August 27, 2020 |
| APPL NO | 17/638363 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4848 (20130101) Original (OR) Class A61B 6/037 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220323079 | Maitland et al. |
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| APPLICANT(S) | THE TEXAS A and M UNIVERSITY SYSTEM (College Station, Texas); SHAPE MEMORY MEDICAL, INC. (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Duncan J. Maitland (College Station, Texas); Todd L. Landsman (San Jose, California); Jennifer N. Rodriguez (Fremont, California); Anthony J. Boyle (College Station, Texas); Alan C. Glowczwski (College Station, Texas); Mark A. Wierzbicki (College Station, Texas) |
| ABSTRACT | An embodiment includes a system comprising: an outer conduit; a shape memory polymer (SMP) foam; a metal backbone including: (a)(i) a first portion that extends from the SMP foam proximal end to the SMP foam distal end and which is generally covered by the SMP foam, and (a)(ii) a distal portion that extends distally from the SMP foam distal end and which is not covered by the SMP foam; wherein: (b)(i) SMP foam and the metal backbone are both included within the outer conduit adjacent to the outer conduit distal end; (b)(ii) the metal backbone distal portion transitions from a secondary shape that is uncoiled to a primary shape that is coiled; and (b)(iii) the metal backbone distal portion is in the metal backbone distal portion secondary shape and is located between the SMP foam distal end and the distal end of the outer conduit. |
| FILED | Wednesday, June 22, 2022 |
| APPL NO | 17/846449 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/1215 (20130101) A61B 17/1219 (20130101) Original (OR) Class A61B 17/12109 (20130101) A61B 17/12172 (20130101) A61B 2017/00526 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220323088 | MAXWELL et al. |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam D. MAXWELL (Ann Arbor, Michigan); Zhen XU (Ann Arbor, Michigan); Hitinder S. GURM (Ann Arbor, Michigan); Charles A. CAIN (Ann Arbor, Michigan) |
| ABSTRACT | Methods for performing non-invasive thrombolysis with ultrasound using, in some embodiments, one or more ultrasound transducers to focus or place a high intensity ultrasound beam onto a blood clot (thrombus) or other vascular inclusion or occlusion (e.g., clot in the dialysis graft, deep vein thrombosis, superficial vein thrombosis, arterial embolus, bypass graft thrombosis or embolization, pulmonary embolus) which would be ablated (eroded, mechanically fractionated, liquefied, or dissolved) by ultrasound energy. The process can employ one or more mechanisms, such as of cavitational, sonochemical, mechanical fractionation, or thermal processes depending on the acoustic parameters selected. This general process, including the examples of application set forth herein, is henceforth referred to as “Thrombolysis.” |
| FILED | Friday, June 10, 2022 |
| APPL NO | 17/838085 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0536 (20130101) A61B 17/2258 (20130101) A61B 17/22004 (20130101) Original (OR) Class Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 37/0092 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220323313 | Deng et al. |
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| APPLICANT(S) | Yale University (New Haven, Connecticut) |
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| INVENTOR(S) | Yang Deng (Edison, New Jersey); Asiri Ediriwickrema (Cary, North Carolina); William M. Saltzman (New Haven, Connecticut) |
| ABSTRACT | Core-shell particles and methods of making and using thereof are described herein. The core is formed of or contains one or more hydrophobic materials or more hydrophobic materials. The shell is formed of or contains hyperbranched polyglycerol (HPG). The HPG coating can be modified to adjust the properties of the particles. Unmodified HPG coatings impart stealth properties to the particles which resist non-specific protein absorption and increase circulation in the blood. The hydroxyl groups on the HPG coating can be chemically modified to form functional groups that react with functional groups and adhere the particles to tissue, cells, or extracellular materials, such as proteins. |
| FILED | Thursday, June 16, 2022 |
| APPL NO | 17/842376 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 8/90 (20130101) A61K 8/0241 (20130101) Original (OR) Class A61K 9/0014 (20130101) A61K 9/0019 (20130101) A61K 9/0053 (20130101) A61K 9/1647 (20130101) A61K 9/5031 (20130101) A61K 9/5146 (20130101) A61K 9/5153 (20130101) A61K 31/427 (20130101) A61K 31/4178 (20130101) A61K 31/4745 (20130101) A61K 47/34 (20130101) A61K 2800/412 (20130101) A61K 2800/413 (20130101) A61K 2800/624 (20130101) Specific Use of Cosmetics or Similar Toilet Preparations A61Q 17/04 (20130101) Acyclic or Carbocyclic Compounds C07C 59/06 (20130101) C07C 59/08 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 83/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220323357 | Fernandes et al. |
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| APPLICANT(S) | The George Washington University (Washington, District of Columbia) |
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| INVENTOR(S) | Rohan Fernandes (Washington, District of Columbia); Elizabeth Sweeney (Washington, District of Columbia); Preethi Bala Balakrishnan (Washington, District of Columbia); Jacob Medina (Washington, District of Columbia) |
| ABSTRACT | Embodiments of the instant disclosure relate to novel methods and compositions for treating tumors resistant to immune checkpoint inhibitors. In certain embodiments, compositions herein can have at least one nanoparticle formed of Prussian blue materials and, optionally, one or more CD137 agonists. In other embodiments, methods of treating tumors herein can include administering an effective amount of at least photothermal therapy agent in combination with at least one CD137 agonist separately or in a combination therapy/combination composition. |
| FILED | Tuesday, April 05, 2022 |
| APPL NO | 17/714010 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/51 (20130101) A61K 9/143 (20130101) Original (OR) Class A61K 9/282 (20130101) A61K 9/2873 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/067 (20210801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220323369 | Xu |
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| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
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| INVENTOR(S) | Qiaobing Xu (Lexington, Massachusetts) |
| ABSTRACT | Disclosed are (i) compounds of formula I, or pharmaceutically acceptable salts thereof; and (ii) lipidoid nanoparticles comprising compound of formula I or pharmaceutically acceptable salts thereof, as well as their use as vehicles for drug delivery across the blood-brain barrier. |
| FILED | Monday, June 13, 2022 |
| APPL NO | 17/838891 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5123 (20130101) Original (OR) Class A61K 38/45 (20130101) A61K 45/06 (20130101) Acyclic or Carbocyclic Compounds C07C 215/20 (20130101) C07C 323/58 (20130101) Heterocyclic Compounds C07D 209/20 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2310/11 (20130101) C12N 2320/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220323389 | AVANTAGGIATI |
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| APPLICANT(S) | GEORGETOWN UNIVERSITY (Washington, District of Columbia) |
| ASSIGNEE(S) | GEORGETOWN UNIVERSITY (Washington, District of Columbia) |
| INVENTOR(S) | Maria Laura AVANTAGGIATI (Kensington, Maryland) |
| ABSTRACT | Provided herein are methods for treating nonalcoholic fatty liver disease (NAFLD) or nonalcoholic steatohepatitis (NASH) in a subject, comprising administering to a subject having NAFLD or NASH an effective amount of a SLC25A1 inhibitor. |
| FILED | Wednesday, August 26, 2020 |
| APPL NO | 17/638383 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/08 (20130101) A61K 31/22 (20130101) A61K 31/40 (20130101) A61K 31/155 (20130101) A61K 31/196 (20130101) Original (OR) Class A61K 31/355 (20130101) A61K 31/366 (20130101) A61K 31/405 (20130101) A61K 31/4192 (20130101) A61K 31/4439 (20130101) A61K 47/02 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) A61P 3/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220323400 | Chen et al. |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan); WAYNE STATE UNIVERSITY (DETROIT, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yuqing Chen (Ann Arbor, Michigan); Jifeng Zhang (Ann Arbor, Michigan); Jie Xu (Ann Arbor, Michigan); Xiubin Liang (Ann Arbor, Michigan); Jian-Ping Jin (DETROIT, Michigan); Fei Sun (Canton, Michigan) |
| ABSTRACT | This invention is in the field of medicinal pharmacology. In particular, the present invention relates to pharmaceutical agents which function as inhibitors of sodium-glucose cotransporter (SGLT) activity. The invention further relates to methods of treating and/or ameliorating symptoms related to cystic fibrosis (CF), comprising administering to a subject (e.g., a human patient) a composition comprising one or more pharmaceutical agents which function as inhibitors of SGLT activity. |
| FILED | Friday, September 04, 2020 |
| APPL NO | 17/639831 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/351 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) A61P 11/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220323406 | Mead et al. |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
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| INVENTOR(S) | Benjamin Mead (Cambridge, Massachusetts); Alexander K. Shalek (Cambridge, Massachusetts); Jeffrey Karp (Boston, Massachusetts); Kazuki Hattori (Cambridge, Massachusetts) |
| ABSTRACT | The subject matter disclosed herein is generally directed to modulation of genes and pathways that drive differentiation of LGR5+ stem cells. The methods and compositions can be used to treat diseases associated with aberrant epithelial barrier function. |
| FILED | Friday, June 05, 2020 |
| APPL NO | 17/617048 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/366 (20130101) Original (OR) Class A61K 31/506 (20130101) A61K 35/36 (20130101) A61K 35/38 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0679 (20130101) C12N 2533/90 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220323415 | KATES et al. |
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| APPLICANT(S) | Michael J. KATES (Philadelphia, Pennsylvania); The University of Chicago (Chicago, Illinois); IIT Research Institute (Chicago, Illinois) |
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| INVENTOR(S) | Michael J. KATES (Philadelphia, Pennsylvania); Nanduri R. PRABHAKAR (Chicago, Illinois); David L. MCCORMICK (Chicago, Illinois); Miguel MUZZIO (Chicago, Illinois) |
| ABSTRACT | Described herein are novel γ- and δ-propargyl carboxylic acids and esters. The novel compositions are antagonists of CSE and may be used to modulate of the activity of the carotid body, therefore providing therapeutic benefits for sleep-related breathing disorders and related conditions. |
| FILED | Friday, June 24, 2022 |
| APPL NO | 17/808645 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/197 (20130101) A61K 31/198 (20130101) A61K 31/216 (20130101) A61K 31/221 (20130101) A61K 31/275 (20130101) A61K 31/381 (20130101) A61K 31/4164 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) Acyclic or Carbocyclic Compounds C07C 229/30 (20130101) C07C 255/07 (20130101) Heterocyclic Compounds C07D 277/30 (20130101) C07D 333/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220323417 | BOZIK et al. |
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| APPLICANT(S) | Knopp Biosciences LLC (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | Knopp Biosciences LLC (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Michael E. BOZIK (Pittsburgh, Pennsylvania); Steven DWORETZKY (Jefferson Hills, Pennsylvania); Kelly PICCHIONE (Pittsburgh, Pennsylvania); Gregory HEBRANK (Greensburg, Pennsylvania); Thomas PETZINGER, Jr. (Pittsburgh, Pennsylvania) |
| ABSTRACT | Provided herein are compounds and pharmaceutical compositions comprising a therapeutically effective amount of such compounds, or pharmaceutically acceptable salts, and a pharmaceutically acceptable excipient, and methods of treating neurodevelopmental diseases or disorders (NDD) and developmental and epileptic encephalopathy (DEE), comprising administering such compounds, or pharmaceutically acceptable salts, and pharmaceutical compositions, to pediatric patients. |
| FILED | Thursday, September 17, 2020 |
| APPL NO | 17/641607 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4184 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220323419 | TANG et al. |
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| FUNDED BY |
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| APPLICANT(S) | FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (Tallahassee, Florida); The United States of America, as represented by the Secretary, Department of Health and Human (Bethesda, Maryland); THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | HENGLI TANG (TALLAHASSEE, Florida); EMILY M. LEE (TALLAHASSEE, Florida); WEI ZHENG (ROCKVILLE, Maryland); RUILI HUANG (ROCKVILLE, Maryland); MIAO XU (ROCKVILLE, Maryland); WENWEI HUANG (ROCKVILLE, Maryland); KHALIDA SHAMIM (ROCKVILLE, Maryland); GUOLI MING (PHILADELPHIA, Pennsylvania); HONGJUN SONG (PHILADELPHIA, Pennsylvania) |
| ABSTRACT | The present invention concerns the use of compounds and compositions for the treatment or prevention of Flavivirus infections, such as dengue virus infections and Zika virus infections. Aspects of the invention include methods for treating or preventing Flavivirus virus infection, such as dengue virus and Zika virus infection, by administering a compound or composition of the invention, to a subject in need thereof; methods for inhibiting Flavivirus infections, such as dengue virus and Zika virus infections, in a cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits useful for treating or preventing Flavivirus infections, such as dengue virus and Zika virus infections. |
| FILED | Tuesday, June 28, 2022 |
| APPL NO | 17/809327 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/165 (20130101) A61K 31/245 (20130101) A61K 31/336 (20130101) A61K 31/352 (20130101) A61K 31/422 (20130101) A61K 31/427 (20130101) A61K 31/433 (20130101) A61K 31/506 (20130101) A61K 31/517 (20130101) A61K 31/519 (20130101) A61K 31/554 (20130101) A61K 31/4162 (20130101) A61K 31/4184 (20130101) Original (OR) Class A61K 31/4535 (20130101) A61K 31/4709 (20130101) A61K 31/4741 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220323420 | TANG et al. |
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| FUNDED BY |
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| APPLICANT(S) | FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (Tallahassee, Florida); The United States of America, as represented by the Secretary , Department of Health and Human Servi (Bethesda, Maryland); THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | HENGLI TANG (TALLAHASSEE, Florida); EMILY M. LEE (TALLAHASSEE, Florida); WEI ZHENG (ROCKVILLE, Maryland); RUILI HUANG (ROCKVILLE, Maryland); MIAO XU (ROCKVILLE, Maryland); WENWEI HUANG (ROCKVILLE, Maryland); KHALIDA SHAMIM (ROCKVILLE, Maryland); GUOLI MING (PHILADELPHIA, Pennsylvania); HONGJUN SONG (PHILADELPHIA, Pennsylvania) |
| ABSTRACT | The present invention concerns the use of compounds and compositions for the treatment or prevention of Flavivirus infections, such as dengue virus infections and Zika virus infections. Aspects of the invention include methods for treating or preventing Flavivirus virus infection, such as dengue virus and Zika virus infection, by administering a compound or composition of the invention, to a subject in need thereof; methods for inhibiting Flavivirus infections, such as dengue virus and Zika virus infections, in a cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits useful for treating or preventing Flavivirus infections, such as dengue virus and Zika virus infections. |
| FILED | Tuesday, June 28, 2022 |
| APPL NO | 17/809353 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/165 (20130101) A61K 31/245 (20130101) A61K 31/336 (20130101) A61K 31/352 (20130101) A61K 31/422 (20130101) A61K 31/427 (20130101) A61K 31/433 (20130101) A61K 31/506 (20130101) A61K 31/517 (20130101) A61K 31/519 (20130101) A61K 31/554 (20130101) A61K 31/4162 (20130101) A61K 31/4184 (20130101) Original (OR) Class A61K 31/4535 (20130101) A61K 31/4709 (20130101) A61K 31/4741 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20220323425 — CO-POTENTIATORS FOR THERAPY OF CYSTIC FIBROSIS CAUSED BY MINIMAL FUNCTION CFTR MUTANTS
| US 20220323425 | VERKMAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alan S. VERKMAN (Oakland, California); Puay-Wah PHUAN (Oakland, California); Peter M. HAGGIE (Oakland, California) |
| ABSTRACT | Provided herein are combination-potentiator (“co-potentiator”) therapeutic regimens, which can be used to modulate cystic fibrosis transmembrane conductance regulator (CTFR) mutant proteins. Co-potentiators have potential utility for treatment of many loss-of-function mutations of the CFTR chloride channel (e.g., N1303K). |
| FILED | Friday, August 28, 2020 |
| APPL NO | 17/639311 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/47 (20130101) A61K 31/438 (20130101) Original (OR) Class A61K 31/4245 (20130101) A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220323505 | MOSHAVERINIA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Alireza MOSHAVERINIA (Los Angeles, California); Sevda POURAGHAEI SEVARI (Newbury Park, California) |
| ABSTRACT | Methods are described for preparing auditory progenitor cells from gingival mesenchymal cells, for uses such as restoring hearing in hearing impaired individuals. In one aspect, a method of treating hearing loss associated with loss of sensory neurons in a human subject is provided, the method comprising the steps of: a. obtaining a population of gingival mesenchymal stem cells (GMSCs); b. optionally expanding the population of GMSCs in vitro; c. encapsulating the population of GMSCs in an elastic three-dimensional scaffold; d. exposing the encapsulated population of GMSCs to a composition comprising one or more growth factors; e. allowing co a sufficient period for the population of GMSCs to differentiate towards auditory progenitor cells; f. optionally retrieving the auditory progenitor cells from the scaffold; and g. introducing the auditory progenitor cells into the inner ear of the subject. |
| FILED | Friday, September 11, 2020 |
| APPL NO | 17/640267 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0012 (20130101) C12N 5/062 (20130101) C12N 2501/11 (20130101) C12N 2501/105 (20130101) C12N 2501/115 (20130101) C12N 2501/155 (20130101) C12N 2506/1361 (20130101) C12N 2533/20 (20130101) C12N 2533/74 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220323506 | ROSTAMI et al. |
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| FUNDED BY |
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| APPLICANT(S) | THOMAS JEFFERSON UNIVERSITY (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Abdolmohamad ROSTAMI (Gladwyne, Pennsylvania); Giacomo CASELLA (Philadelphia, Pennsylvania); Bogoljub CIRIC (Philadelphia, Pennsylvania); Guang-Xian ZHANG (Philadelphia, Pennsylvania) |
| ABSTRACT | In various aspects and embodiments the invention provides a method of treating multiple sclerosis in a subject in need thereof, the method comprising administering to the subject an effective amount of an oligodendrocyte-derived extracellular vesicle. |
| FILED | Wednesday, June 03, 2020 |
| APPL NO | 17/615975 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0043 (20130101) A61K 9/0053 (20130101) A61K 35/30 (20130101) Original (OR) Class A61K 47/26 (20130101) A61K 47/38 (20130101) A61K 47/42 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) A61P 37/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20220323553 — Epigenomic editing and reactivation of targets for the treatment of Fragile X syndrome
| US 20220323553 | Phillips-Cremins et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jennifer E. Phillips-Cremins (Philadelphia, Pennsylvania); Linda Zhou (Philadelphia, Pennsylvania); Chunmin Ge (Philadelphia, Pennsylvania) |
| ABSTRACT | The present invention generally relates to compositions and methods for modulating heterochromatin content or the level or activity of a gene or gene product that has been silenced by the formation of heterochromatin regions and the use thereof for the prevention and treatment of fragile X syndrome and diseases and disorders associated with fragile X syndrome. |
| FILED | Tuesday, March 08, 2022 |
| APPL NO | 17/689867 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7105 (20130101) A61K 38/465 (20130101) Original (OR) Class A61K 39/0005 (20130101) A61K 2039/53 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 43/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220323562 | WU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Protein Potential, LLC (Rockville, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yun WU (Rockville, Maryland); Dennis J. KOPECKO (Silver Spring, Maryland); B. Kim Lee SIM (Gaithersburg, Maryland); Stephen L. HOFFMAN (Gaithersburg, Maryland) |
| ABSTRACT | Disclosed is the attenuated Salmonella typhi vaccine Ty21a utilized as a vector for Shigella and/or enterotoxogenic E. coli genes stably integrated in the Ty21a chromosome. These genes include a heterologous Shigella sonnei O-antigen biosynthetic gene region that comprises the wzz gene and expresses Shigella sonnei form 1 O-antigen, as well as a heterologous acid resistance biosynthetic gene system comprising a YbaS gene, which enables increased stability of the Ty21a vector at pH 2.5 relative to Ty21a without the integrated acid resistance biosynthetic gene system. |
| FILED | Monday, April 25, 2022 |
| APPL NO | 17/660558 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0275 (20130101) A61K 39/0283 (20130101) Original (OR) Class A61K 2039/522 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220323563 | SCHNEEWIND et al. |
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| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | The University of Chicago (Chicago, Illinois) |
| INVENTOR(S) | Olaf SCHNEEWIND (Chicago, Illinois); Dominique MISSIAKAS (Chicago, Illinois); Yan SUN (Chicago, Illinois); Hwan Keun KIM (Chicago, Illinois); Miaomiao SHI (Chicago, Illinois); Xinhai CHEN (Chicago, Illinois) |
| ABSTRACT | Embodiments concern methods and composition for preventing or treating a bacterial infection, particularly infection by a Staphylococcus bacterium. The embodiments concern improved non-toxigenic Protein A (SpA) variant. |
| FILED | Wednesday, May 13, 2020 |
| APPL NO | 17/595252 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/085 (20130101) Original (OR) Class A61K 47/42 (20130101) A61K 2039/545 (20130101) Peptides C07K 14/31 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220323568 | OOMENS |
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| FUNDED BY |
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| APPLICANT(S) | Board of Regents for Oklahoma State University (Stillwater, Oklahoma) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Antonius G. P. OOMENS (Stillwater, Oklahoma) |
| ABSTRACT | Recombinant, live, attenuated viruses of the Pneumoviridae family are disclosed that include a baculovirus GP64 envelope glycoprotein or variant or fragment thereof and a respiratory syncytial virus (RSV) F protein variant or fragment thereof. Also disclosed are polynucleotides encoding the virus as well as pharmaceutical compositions and vaccines containing the virus. In addition, methods of producing and using each of the above compositions are also disclosed. |
| FILED | Friday, June 24, 2022 |
| APPL NO | 17/848637 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class A61K 39/39 (20130101) A61K 2039/5254 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/12 (20180101) A61P 31/14 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220323570 | WALKER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts); Massachusetts Eye and Ear Infirmary (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bruce D. WALKER (Nahant, Massachusetts); Gaurav D. GAIHA (Somerville, Massachusetts); Elizabeth ROSSIN (Charlestown, Massachusetts) |
| ABSTRACT | A method of preventing or treating HIV in a subject includes selecting two or more HIV CTL epitopes from an HIV proteome that have a network score that meets a threshold value. The network score for a given epitope can be determined by generating at least one network representing protein structure, calculating a set of network parameters, combining the network parameters to determine a network score for each amino acid residue in the protein structure, generating a network score for each of a plurality of epitopes as a weighted linear combination of the amino acid residues of the epitopes, and selecting two or more epitopes according to their network score. An effective amount of a T cell immunogen composition and a pharmaceutically acceptable carrier is administered to the subject. The T cell immunogen composition includes the two or more selected HIV CTL epitopes. |
| FILED | Thursday, March 12, 2020 |
| APPL NO | 17/437470 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/21 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) A61P 37/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220323579 | Casanova |
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| FUNDED BY |
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| APPLICANT(S) | The Rockefeller University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jean-Laurent Casanova (NY, New York) |
| ABSTRACT | The invention relates to mutations and alterations in the inflammatory pathway, including IL-18BP and IL-10RB mutations, that are associated with the development of fulminant viral hepatitis following viral infection, such as following hepatitis virus infection. The invention relates to methods for treating or ameliorating viral hepatitis comprising administering IL-18BP, IL-18 antagonist, IFNγ antagonist or inhibitor, and/or IL-10RB or an IL-10 antagonist. |
| FILED | Thursday, June 04, 2020 |
| APPL NO | 17/615900 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/454 (20130101) A61K 31/498 (20130101) A61K 31/513 (20130101) A61K 31/522 (20130101) A61K 31/675 (20130101) A61K 31/7072 (20130101) A61K 38/1709 (20130101) A61K 39/3955 (20130101) Original (OR) Class A61K 48/005 (20130101) A61K 2039/507 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) A61P 31/12 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220323587 | CROYLE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| INVENTOR(S) | Maria A. CROYLE (Austin, Texas); Stephen Clay SCHAFER (Austin, Texas) |
| ABSTRACT | Disclosed herein are compositions and methods for storing biologically active polypeptides. When the biologically active polypeptides are formulated appropriately within the compositions, they can be stored at room temperature for extended periods of time and retain a significant amount of activity prior to storage. Examples of the activity that is retained is at least about 70% to 95% activity prior to storage. Duration of storage may be for extended amounts of time, for example 1 week, 2 weeks, 1 month, 2 months, 4 months, 6 months, 8 months, or longer than a year. Methods for administering, formulating and stabilizing the biologically active polypeptides are also disclosed. |
| FILED | Tuesday, June 28, 2022 |
| APPL NO | 17/851447 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0053 (20130101) A61K 9/7007 (20130101) A61K 47/18 (20130101) A61K 47/26 (20130101) Original (OR) Class A61K 47/34 (20130101) Peptides C07K 16/38 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220323616 | Wu et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board Of Trustees Of The Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sean M. Wu (Stanford, California); William R. Goodyer (Stanford, California); Benjamin Beyersdorf (Stanford, California); Nynke Van Den Berg (Stanford, California); Eben Rosenthal (Stanford, California) |
| ABSTRACT | Antibodies which bind selectively to cardiac conduction system (CCS) cells, imaging and/or diagnostic reagents and compositions visualizing the CCS cells and therapeutic products and compositions comprising one or more of the antibodies. Methods for delivering therapeutic agents to the CCS cells. The disclosure further provides methods for visualizing the CCS cells in vivo in real time, including in a subject undergoing a cardiothoracic surgery or other cardiac intervention. Compositions and methods for isolation, purification, analyses and/or transplantation of the CCS cells, including pluripotent stem cell (hiPSC)-derived or human embryonic stem cell (hESC)-derived CCS cells. |
| FILED | Tuesday, July 07, 2020 |
| APPL NO | 17/625224 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6803 (20170801) A61K 47/6913 (20170801) A61K 49/0013 (20130101) A61K 49/0058 (20130101) Original (OR) Class A61K 2039/505 (20130101) Peptides C07K 16/18 (20130101) C07K 2317/31 (20130101) C07K 2317/54 (20130101) C07K 2317/55 (20130101) C07K 2317/622 (20130101) C07K 2317/626 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0657 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/582 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220323646 | Badylak et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Eduction (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen F. Badylak (West Lafayette, Indiana); Julie Anne Phillippi (Pittsburgh, Pennsylvania); Thomas G. Gleason (Pittsburgh, Pennsylvania); George R. Fercana (Pittsburgh, Pennsylvania) |
| ABSTRACT | Provided herein are methods of making an ECM gel from vascular tissue. Also provided herein are ECM compositions prepared from vascular tissue, and methods of use of those compositions, for example in treatment of aneurysms, and for vascularization or re-vascularization. |
| FILED | Thursday, June 23, 2022 |
| APPL NO | 17/808423 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/12 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/52 (20130101) A61L 27/225 (20130101) A61L 27/507 (20130101) A61L 27/3625 (20130101) Original (OR) Class A61L 27/3633 (20130101) A61L 27/3687 (20130101) A61L 27/3691 (20130101) A61L 2430/20 (20130101) Peptides C07K 14/75 (20130101) C07K 14/745 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2533/90 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220323750 | Irazoqui et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pedro Irazoqui (Lafayette, Indiana); Ryan Benjamin Budde (Indianapolis, Indiana); Daniel Pederson (Lafayette, Indiana) |
| ABSTRACT | Systems and techniques can prevent reflux induced laryngospasm and the pathologies resulting therefrom, including (but not limited to) sudden death in epilepsy (SUDEP) and sudden infant death syndrome (SIDS). |
| FILED | Thursday, June 30, 2022 |
| APPL NO | 17/855001 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/113 (20130101) A61B 5/0205 (20130101) A61B 5/4809 (20130101) A61B 5/14539 (20130101) A61B 2503/04 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0517 (20130101) A61N 1/3601 (20130101) Original (OR) Class A61N 1/36064 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220323765 | GRILL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Warren M. GRILL (Chapel Hill, North Carolina); David T. BROCKER (Cary, North Carolina); Alexander R. KENT (Durham, North Carolina) |
| ABSTRACT | The present invention relates to methods that enable one to design temporal patterns for the optimal stimulation of a nervous system, one or more nerve cells, or nervous tissue. In one embodiment, the present invention relates to methods to design improved stimulation patterns and/or genetic algorithms for the optimal stimulation of a nervous system, one or more nerve cells, or nervous tissue. In one embodiment, the present invention utilizes a model-based design to achieve a more optimal stimulation pattern for use in connection with a nervous system, one or more nerve cells, or nervous tissue (e.g., a human nervous system). In another embodiment, the model-based design of the present invention utilizes a systematic search method to identify parameters (e.g., design variables) that minimize a cost function (e.g., optimize the fitness of a particular design). In one instance, the system and method of the present invention is demonstrated via optimal temporal patterns of electrical stimulation for a nervous system, one or more nerve cells, or nervous tissue. |
| FILED | Monday, May 02, 2022 |
| APPL NO | 17/734167 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/3606 (20130101) A61N 1/36067 (20130101) A61N 1/36075 (20130101) A61N 1/36132 (20130101) A61N 1/36139 (20130101) Original (OR) Class A61N 1/36171 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/20 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/30 (20180101) G16H 50/50 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220323956 | Eltoukhy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Illumina, Inc. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Helmy A. Eltoukhy (San Diego, California); Tarun Khurana (San Diego, California); Behnam Javanmardi (San Diego, California); Poorya Sabounchi (San Diego, California); Majid Aghababazadeh (San Diego, California) |
| ABSTRACT | A flow cell including inlet and outlet ports in fluid communication with each other through a flow channel that extends therebetween. The flow channel includes a diffuser region and a field region that is located downstream from the diffuser region. The field region of the flow channel directs fluid along reaction sites where desired reactions occur. The fluid flows through the diffuser region in a first flow direction and through the field region in a second flow direction. The first and second flow directions being substantially perpendicular. |
| FILED | Friday, June 24, 2022 |
| APPL NO | 17/848840 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5085 (20130101) B01L 3/502715 (20130101) Original (OR) Class B01L 7/52 (20130101) B01L 2200/04 (20130101) B01L 2200/10 (20130101) B01L 2200/16 (20130101) B01L 2200/025 (20130101) B01L 2200/082 (20130101) B01L 2300/022 (20130101) B01L 2300/023 (20130101) B01L 2300/048 (20130101) B01L 2300/161 (20130101) B01L 2300/165 (20130101) B01L 2300/0627 (20130101) B01L 2300/0636 (20130101) B01L 2300/0645 (20130101) B01L 2300/0654 (20130101) B01L 2300/0819 (20130101) B01L 2300/0877 (20130101) B01L 2400/0457 (20130101) B01L 2400/0487 (20130101) B01L 2400/0622 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) C12Q 1/6874 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220323960 | Baday et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Murat Baday (Menlo Park, California); Naside Gozde Durmus (Palo Alto, California); Semih Calamak (Palo Alto, California); Utkan Demirci (Stanford, California); Ronald W. Davis (Palo Alto, California); Lars Steinmetz (San Francisco, California); Jaeyoung Yang (Palo Alto, California); Thiruppathiraja Chinnasamy (Mountain View, California); Alessandro Tocchio (San Francisco, California) |
| ABSTRACT | A heterogeneous population of cells are separated and collected according to a method. The heterogeneous population of cells in a paramagnetic medium are placed in a fluidic channel in which the fluidic channel comprises two or more outlets. The heterogeneous population of cells in the fluidic channel are separated based on differences in magnetic susceptibility and density of the heterogeneous population of cells. Fluid comprising the separated cells is withdrawn from the two or more outlets using variable flow rates by fluidic pumps at respective ones of the two or more outlets simultaneously to fractionalize the fluid comprising the separated cells across the two or more outlets by manipulation of the variable flow rates relative to one another. |
| FILED | Wednesday, April 20, 2022 |
| APPL NO | 17/724729 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) Original (OR) Class B01L 3/502784 (20130101) B01L 2200/0652 (20130101) B01L 2300/0864 (20130101) B01L 2400/043 (20130101) Magnetic or Electrostatic Separation of Solid Materials From Solid Materials or Fluids; Separation by High-voltage Electric Fields B03C 1/32 (20130101) B03C 1/288 (20130101) B03C 2201/18 (20130101) B03C 2201/26 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/14 (20130101) G01N 33/574 (20130101) G01N 33/4875 (20130101) G01N 33/54366 (20130101) G01N 33/56966 (20130101) G01N 2015/1486 (20130101) Image Data Processing or Generation, in General G06T 7/0016 (20130101) G06T 2207/30101 (20130101) G06T 2207/30242 (20130101) G06T 2211/428 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220324194 | Bottlang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | WAVECEL, LLC (Wilsonville, Oregon) |
| ASSIGNEE(S) | WAVECEL, LLC (Wilsonville, Oregon) |
| INVENTOR(S) | Michael Bottlang (Happy Valley, Oregon); Jeffrey Bennett (Portland, Oregon) |
| ABSTRACT | An impact-absorbing structure that includes a plurality of interconnected cells forming a sheet, each cell having a sidewall and a longitudinal axis. Each cell may be configured to absorb energy through plastic deformation in response to an applied load, and a sidewall of at least one cell may include a geometric perturbation that is oriented in a direction that is not parallel to the longitudinal axis of the cell. The geometric perturbation may reduce the load required to cause plastic deformation of the cell. |
| FILED | Thursday, January 27, 2022 |
| APPL NO | 17/586246 |
| CURRENT CPC | Hats; Head Coverings A42B 3/065 (20130101) Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 3/12 (20130101) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Springs; Shock-absorbers; Means for Damping Vibration F16F 7/121 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220324796 | Ausubel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts); Rhode Island Hospital, A Lifespan- Partner (Providence, Rhode Island); Emory Univerversity (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Frederick M. Ausubel (Newton, Massachusetts); Wooseong Kim (Providence, Rhode Island); Eleftherios Mylonakis (Providence, Rhode Island); William M. Wuest (Atlanta, Georgia) |
| ABSTRACT | The present application provides compounds and methods for treating bacterial infections, including bacterial infections caused by MRSA. |
| FILED | Thursday, June 11, 2020 |
| APPL NO | 17/618333 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Acyclic or Carbocyclic Compounds C07C 49/786 (20130101) C07C 317/14 (20130101) C07C 321/30 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220324846 | TENG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Forge Therapeutics, Inc. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Min TENG (San Diego, California); Baskar NAMMALWAR (San Diego, California); Xiaoming LI (San Diego, California); Christian PEREZ (San Diego, California); Ian YULE (Abingdon, United Kingdom); Adele FAULKNER (Abingdon, United Kingdom); Holly ATTON (Abingdon, United Kingdom); Alastair PARKES (Abingdon, United Kingdom); Serge CONVERS-REIGNIER (Abingdon, United Kingdom); Michelle SOUTHEY (Abingdon, United Kingdom); David T. PUERTA (San Diego, California) |
| ABSTRACT | Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting the growth of gram-negative bacteria. Furthermore, the subject compounds and compositions are useful for the treatment of bacterial infection, such as urinary tract infection and the like. |
| FILED | Thursday, June 09, 2022 |
| APPL NO | 17/836255 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Heterocyclic Compounds C07D 239/54 (20130101) C07D 401/06 (20130101) C07D 401/10 (20130101) C07D 401/12 (20130101) C07D 403/10 (20130101) C07D 403/14 (20130101) Original (OR) Class C07D 405/12 (20130101) C07D 405/14 (20130101) C07D 409/12 (20130101) C07D 413/14 (20130101) C07D 487/04 (20130101) C07D 491/048 (20130101) C07D 491/107 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220324849 | HADDEN |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Connecticut (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Kyle HADDEN (Ellington, Connecticut) |
| ABSTRACT | Disclosed herein are analogues of itraconazole that are potent hedgehog signaling pathway inhibitors. The compounds are expected to be useful in the treatment of cell proliferation disorders such as cancer, particularly cancers that are dependent upon the hedgehog signaling pathway such as basal cell carcinoma and medulloblastoma. |
| FILED | Friday, August 07, 2020 |
| APPL NO | 17/633679 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 317/22 (20130101) C07D 405/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220324891 | Harman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Walter Dean Harman (Earlysville, Virginia); Jacob Smith (Burke, Virginia); Katy Wilson (Charlottesville, Virginia); Kevin David Welch (Charlottesville, Virginia); Justin H. Wilde (Bristol, Connecticut) |
| ABSTRACT | A method for preparing isotopologues and/or stereoisotopomers of cyclic and heterocyclic alkenes and dienes is described. The method provides regio- and/or stereospecific addition of hydrogen, deuterium, tritium and a variety of other substituents to arenes, heteroarenes, and alicyclic compounds that have multiple carbon-carbon double bonds, thereby providing discrete isotopologues and stereoisotopomers of cyclic and heterocyclic alkenes and dienes with high isotopic purity and in high enantiomeric excess. Also described are isotopologues and stereoisotopomers of cyclic and heterocyclic alkenes and dienes, such as isotopologues and stereoisotopomers of cyclohexene and tetrahydropyridine, as well as products thereof, such as isotopologues and stereoisotopomers of piperidines and piperidine-containing compounds, such as methylphenidate. In addition, a method of determining the absolute configuration of stereoisotopomers of cyclohexenes is described. |
| FILED | Wednesday, June 17, 2020 |
| APPL NO | 17/619827 |
| CURRENT CPC | General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/05 (20130101) C07B 2200/07 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 11/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220324902 | MCCALL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ReveraGen BioPharma, Inc. (Rockville, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John M. MCCALL (Boca Grande, Florida); Eric HOFFMAN (Rockville, Maryland); Kanneboyina NAGARAJU (Highland, Maryland); Jesse DAMSKER (Alexandria, Virginia) |
| ABSTRACT | The present invention relates to compounds and methods which may be useful as treatments of diseases. |
| FILED | Friday, December 10, 2021 |
| APPL NO | 17/548030 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/58 (20130101) A61K 31/573 (20130101) Steroids C07J 7/003 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220324907 | LIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York); TRI-INSTITUTIONAL THERAPEUTICS DISCOVERY INSTITUTE (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gang LIN (Forest Hills, New York); Carl NATHAN (Larchmont, New York); Laura KIRKMAN (New York, New York); Wenhu ZHAN (Elmhurst, New York); Trevor MORGAN (Royston, Hertfordshire, United Kingdom); Kenjiro SATO (Fujisawa, Kanagawa, Japan); Ryoma HARA (Tokyo, Japan); Masanori KAWASAKI (Tokyo, Japan); Toshihiro IMAEDA (Fujisawa, Kanagawa, Japan); Akinori TOITA (Minami-ku, Kanagawa, Japan); Rei OKAMOTO (Yokohama, Kanagawa, Japan); Takafumi YUKAWA (Yokohama, Kanagawa, Japan); Kazuyoshi ASO (Yokohama, Kanagawa, Japan); Tzu-Tshin WONG (Acton, Massachusetts); John D. GINN (New Milford, Connecticut); Michael A. FOLEY (New York, New York) |
| ABSTRACT | The compounds of the present invention are represented by the following compounds having Formula I and Formula (I′): where the substituents R1, R2, R2′, R3, R4, R5, R′, R″, X, Y, and Z are as defined herein and where the substituents R1, R2, R3, R4, R5, R′, R″, X, Y, and Z are as defined herein. These compounds are used in the treatment of bacterial infections, parasite infections, fungal infections, cancer, immunologic disorders, autoimmune disorders, neurodegenerative diseases and disorders, inflammatory disorders, or muscular dystrophy or for providing immunosuppression for transplanted organs or tissues. |
| FILED | Thursday, October 11, 2018 |
| APPL NO | 16/755482 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/06 (20180101) Peptides C07K 5/0215 (20130101) Original (OR) Class C07K 11/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220324913 | Van de Water et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Judy Van de Water (Capay, California); Elizabeth Edmiston (Sacramento, California); Nora Alexandra Ramirez Celis (Davis, California) |
| ABSTRACT | The present disclosure provides peptides that specifically bind to maternal autoantibodies that are generated in the mother or potential mother against the endogenous polypeptide antigen neuron specific enolase (NSE) protein. The peptides described herein are useful for determining a risk of an offspring for developing an autism spectrum disorder (ASD) by detecting the presence of maternal autoantibodies in a biological sample of the mother or potential mother. The peptides or mimotopes thereof can also be administered to the mother or potential mother to block the binding between maternal autoantibodies and their antigens, thereby neutralizing the maternal autoantibodies. |
| FILED | Friday, May 13, 2022 |
| APPL NO | 17/744614 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/00 (20130101) Peptides C07K 7/08 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/564 (20130101) G01N 33/6893 (20130101) G01N 2333/988 (20130101) G01N 2800/30 (20130101) G01N 2800/38 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220324915 | Tamerler-Behar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Kansas (Lawrence, Kansas); University of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Candan Tamerler-Behar (Lawrence, Kansas); Emily Wisdom (Albuquerque, New Mexico); Malcolm Snead (Los Angeles, California) |
| ABSTRACT | Described herein is a bifunctional peptide, compositions comprising the same, and methods useful for treatment of peri-implant disease. |
| FILED | Monday, September 07, 2020 |
| APPL NO | 17/641058 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 14/001 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220324918 | Lee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| ASSIGNEE(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| INVENTOR(S) | Frank Jonathan Lee (Minneapolis, Minnesota); Yushun Wan (Chongqing City, China PRC) |
| ABSTRACT | The present disclosure provides engineered SARS-CoV-2 spike ectodomain polypeptides and cells for producing such a polypeptide, as well as compositions and methods thereof. |
| FILED | Tuesday, March 29, 2022 |
| APPL NO | 17/706919 |
| CURRENT CPC | Peptides C07K 14/165 (20130101) Original (OR) Class C07K 2319/01 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220324927 | List et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alan List (Tampa, Florida); Haitao Ji (Tampa, Florida); Vincent Luca (Tampa, Florida) |
| ABSTRACT | Disclosed are compositions and methods for engineered peptide inhibitors of NLRP3 infiammasome and methods of their use in the treatment of Myelodysplastic Syndromes. In one aspect, disclosed herein are engineered inhibitors of NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome comprising a Helix 2 of POP1 comprising one or more substitutions at residues 18, 21, 22, 25, 26, 28, 29, and/or 30 of POP1 as set forth in SEQ ID NO:1. |
| FILED | Friday, May 01, 2020 |
| APPL NO | 17/608021 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Peptides C07K 14/4703 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/102 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220324943 | Golde et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| INVENTOR(S) | Todd Eliot Golde (Gainesville, Florida); Yong Ran (Gainesville, Florida); Marshall S. Goodwin (Gainesville, Florida); Pedro Cruz (Gainesville, Florida); Yona Levites (Gainesville, Florida) |
| ABSTRACT | Provided herein are compositions and methods for the stable production of bioactive small peptides of interest through delivery to target cells based on the fusion of small peptides of interest to a collagen domain of a C1qTNF protein to produce a novel scaffold protein capable of multimerization. Advantageously, the fusion proteins, compositions and methods of the present disclosure meet existing needs in the art by providing for higher stable expression and longer stability of intracellular and secretable peptides of interest. Additionally, the fusion proteins, compositions and methods of the present disclosure provide for improved binding affinity of expressed receptor peptides with ligand binding partners in the target cell. Further provided herein are polynucleotide constructs encoding the described fusion proteins and recombinant adeno-associated viral particles comprising these polynucleotides. Also provided herein are pharmaceutical compositions and nanoparticles that comprise the described fusion proteins. Further provided herein are methods of treating a subject by administering the described fusion proteins, rAAV particles, compositions and/or nanoparticles. |
| FILED | Wednesday, July 22, 2020 |
| APPL NO | 17/629356 |
| CURRENT CPC | Peptides C07K 14/71 (20130101) C07K 14/525 (20130101) C07K 14/4711 (20130101) C07K 14/4747 (20130101) C07K 14/70521 (20130101) C07K 14/70532 (20130101) C07K 14/70596 (20130101) Original (OR) Class C07K 2317/622 (20130101) C07K 2319/21 (20130101) C07K 2319/43 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220324972 | VALLERA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota); GT BIOPHARMA, INC. (Brisbane, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel A. VALLERA (Richfield, Minnesota); Jeffrey S. MILLER (North Oaks, Minnesota); Martin FELICES (Circle Pines, Minnesota); Martin SCHROEDER (San Rafael, California) |
| ABSTRACT | An immunotherapy compound includes an NK cell engaging domain, an NK activating domain and a targeting domain. The targeting domain selectively binds to HER2, HERS, or the HER2/HER3 heterodimer complex and is operably linked to the NK activating domain and the NK cell engaging domain. The compound may be administered to a subject to induce NK-mediated killing of a cancer cell, to stimulate expansion of NK cells in the subject, and/or for treating cancer. |
| FILED | Tuesday, September 15, 2020 |
| APPL NO | 17/641594 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Peptides C07K 14/5443 (20130101) C07K 16/283 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220324973 | Majeti et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ravindra Majeti (Palo Alto, California); Irving L. Weissman (Stanford, California) |
| ABSTRACT | Markers of acute myeloid leukemia stem cells (AMLSC) are identified. The markers are differentially expressed in comparison with normal counterpart cells, and are useful as diagnostic and therapeutic targets. |
| FILED | Wednesday, May 04, 2022 |
| APPL NO | 17/736874 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Peptides C07K 16/28 (20130101) C07K 16/30 (20130101) C07K 16/2803 (20130101) Original (OR) Class C07K 16/2896 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0093 (20130101) C12N 5/0694 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5011 (20130101) G01N 33/57426 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220324982 | Lim et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wendell A. Lim (San Francisco, California); Kole T. Roybal (San Francisco, California); Jasper Z. Williams (San Francisco, California) |
| ABSTRACT | The instant disclosure provides chimeric polypeptides which modulate various cellular processes following a cleavage event induced upon binding of a specific binding member of the polypeptide with its binding partner. Methods of using chimeric polypeptides to modulate cellular functions, including e.g., induction of gene expression, are also provided. Nucleic acids encoding the subject chimeric polypeptides and associated expression cassettes and vectors as well as cells that contain such nucleic acids and/or expression cassettes and vectors are provided. Also provided, are methods of treating a subject using the described components and methods as well as kits for practicing the subject methods. |
| FILED | Wednesday, June 15, 2022 |
| APPL NO | 17/841595 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 39/39558 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/705 (20130101) C07K 14/7051 (20130101) C07K 14/70539 (20130101) C07K 16/30 (20130101) C07K 16/2803 (20130101) C07K 16/2809 (20130101) C07K 16/2833 (20130101) Original (OR) Class C07K 2317/14 (20130101) C07K 2317/31 (20130101) C07K 2317/32 (20130101) C07K 2317/622 (20130101) C07K 2319/00 (20130101) C07K 2319/50 (20130101) C07K 2319/60 (20130101) C07K 2319/80 (20130101) C07K 2319/715 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220324998 | O'Bryan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MUSC Foundation for Research Development (Charleston, South Carolina); New York University (New York, New York); The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John O'Bryan (Charleston, South Carolina); Shohei Koide (New York, New York); Akiko Koide (New York, New York) |
| ABSTRACT | The invention provides compositions and methods for binding Ras in a nucleotide free state (apo RAS) and inhibiting Ras signaling. In one embodiment, the invention provides monobodies that specifically bind apo RAS and methods of use. Thus, in diseases and conditions where a reduction of Ras signaling is beneficial, such inhibitory compositions act as therapeutics. |
| FILED | Thursday, June 18, 2020 |
| APPL NO | 17/620395 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39558 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/32 (20130101) Original (OR) Class C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/569 (20130101) C07K 2319/30 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5748 (20130101) G01N 2333/914 (20130101) G01N 2500/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220325252 | COLLINS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as Represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland); The Research Foundation for the State University of New York (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter L. COLLINS (Silver Spring, Maryland); Cyril LE NOUEN (Bethesda, Maryland); Linda G. BROCK (Bethesda, Maryland); Ursula J. BUCHHOLZ (Silver Spring, Maryland); Joshua Marc DINAPOLI (Lexington, Massachusetts); Steffen MUELLER (Kings Point, New York); Eckard WIMMER (E. Setauket, New York) |
| ABSTRACT | Described herein are RSV polynucleotide sequences that make use of multiple codons that are containing silent nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce a numerous synonymous codons into the genome. Due to the large number of defects involved, the attenuated viruses disclosed herein provide a means of producing attenuated, live vaccines against RSV. |
| FILED | Thursday, June 02, 2022 |
| APPL NO | 17/831259 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/155 (20130101) A61K 2039/5254 (20130101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class C12N 2760/18522 (20130101) C12N 2760/18534 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220325266 | Venditti et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Charles P. Venditti (Potomac, Maryland); Randy J. Chandler (Chevy Chase, Maryland) |
| ABSTRACT | Synthetic polynucleotides encoding human propionyl-CoA carboxylase beta (synPCCB) and exhibiting augmented expression in cell culture and/or in a subject are described herein. An adeno-associated viral (AAV) gene therapy vector encoding synPCCB successfully rescued the neonatal lethal phenotype displayed by propionyl-CoA carboxylase beta (Pccb−/−) deficient mice, lowered circulating methylcitrate levels in the treated animals, and resulted in prolonged hepatic expression of the product of the synPCCB transgene in vivo. |
| FILED | Thursday, October 15, 2020 |
| APPL NO | 17/766067 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/93 (20130101) Original (OR) Class C12N 15/86 (20130101) C12N 2750/14143 (20130101) C12N 2800/22 (20130101) C12N 2830/50 (20130101) C12N 2840/105 (20130101) Enzymes C12Y 604/01003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220325270 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Notre Dame du Lac (Notre Dame, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chenguang Zhang (South Bend, Indiana); Gongchen Sun (South Bend, Indiana); Satyajyoti Senapati (South Bend, Indiana); Hsueh-Chia Chang (South Bend, Indiana) |
| ABSTRACT | Described herein is a bifurcated continuous field-flow fractionation (BCFFF) chip for high-yield and high-throughput nucleic acid extraction and purification. BCFFF uses a membrane ionic transistor to sustain low-ionic strength in a localized region at a junction, such that the resulting high field can selectively isolate high-charge density nucleic acids from the main flow channel and insert them into a standardized buffer in a side channel that bifurcates from the junction. The BCFFF platform can be used for isolation of both long dsDNAs and short miRNAs, without changing the device configuration or the operation protocol. BCFFF results in high-efficiency (>85%) concentration-independent DNA extraction and 40% net qRT-PCR miRNA yield from plasma, which is significantly higher than any other commercial liquid and solid extraction technologies. |
| FILED | Friday, October 02, 2020 |
| APPL NO | 17/639198 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1003 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220325279 | ELLIS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington); FRED HUTCHINSON CANCER RESEARCH CENTER (Seattle, Washington) |
| ASSIGNEE(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington); FRED HUTCHINSON CANCER RESEARCH CENTER (Seattle, Washington) |
| INVENTOR(S) | Daniel ELLIS (Seattle, Washington); Neil KING (Seattle, Washington); Jesse BLOOM (Seattle, Washington); Tyler STARR (Seattle, Washington); Allison GREANEY (Seattle, Washington) |
| ABSTRACT | Provided herein are compositions and methods comprising mutated coronavirus “S” spike proteins or receptor binding domains thereof that have an increased expression level, yield and stability compared to its corresponding native or wild-type coronavirus spike protein under the same expression, culture or storage conditions. These mutated spike proteins can be used for generating a protein-based vaccine against one or more coronaviruses. |
| FILED | Tuesday, December 28, 2021 |
| APPL NO | 17/563271 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) Original (OR) Class C12N 15/64 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6811 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220325319 | Quake et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen R. Quake (Stanford, California); Thomas M. Snyder (Palo Alto, California); Hannah Valantine (Stanford, California) |
| ABSTRACT | The invention provides methods, devices, compositions and kits for diagnosing or predicting transplant status or outcome in a subject who has received a transplant. |
| FILED | Wednesday, June 08, 2022 |
| APPL NO | 17/835821 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) Original (OR) Class C12Q 1/6837 (20130101) C12Q 1/6869 (20130101) C12Q 1/6883 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) G16B 20/20 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20220325325 — METHODS AND SYSTEMS FOR DETERMINING SPATIAL PATTERNS OF BIOLOGICAL TARGETS IN A SAMPLE
| US 20220325325 | CHEE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Prognosys Biosciences, Inc. (San Diego, California) |
| ASSIGNEE(S) | Prognosys Biosciences, Inc. (San Diego, California) |
| INVENTOR(S) | Mark S. CHEE (San Diego, California); David A. ROUTENBERG (San Diego, California) |
| ABSTRACT | The present disclosure provides methods and assay systems for use in spatially encoded biological assays, including assays to determine a spatial pattern of abundance, expression, and/or activity of one or more biological targets across multiple sites in a sample. In particular, the biological targets comprise proteins, and the methods and assay systems do not depend on imaging techniques for the spatial information of the targets. The present disclosure provides methods and assay systems capable of high levels of multiplexing where reagents are provided to a biological sample in order to address tag the sites to which reagents are delivered; instrumentation capable of controlled delivery of reagents; and a decoding scheme providing a readout that is digital in nature. |
| FILED | Thursday, June 02, 2022 |
| APPL NO | 17/830923 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5027 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6809 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220325334 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| INVENTOR(S) | Feng Zhang (Cambridge, Massachusetts); Jonathan Gootenberg (Cambridge, Massachusetts); Omar Abudayyeh (Cambridge, Massachusetts); Julia Joung (Cambridge, Massachusetts); Alim Ladha (Cambridge, Massachusetts); Han Altae-Tran (Cambridge, Massachusetts); Guilhem Faure (Cambridge, Massachusetts) |
| ABSTRACT | Systems and methods for rapid diagnostics related to the use of CRISPR effector systems and optimized guide sequences for detection of coronavirus, including multiplex lateral flow diagnostic devices and methods of use, are provided. |
| FILED | Wednesday, April 27, 2022 |
| APPL NO | 17/731019 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 7/52 (20130101) B01L 2300/0816 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/78 (20130101) C12N 9/1276 (20130101) C12N 2310/20 (20170501) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6844 (20130101) Original (OR) Class C12Q 2600/16 (20130101) C12Q 2600/156 (20130101) Enzymes C12Y 207/07049 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2333/165 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20220325338 — SYSTEMS AND METHODS FOR PERFORMING AND MEASURING HOMOLOGOUS CHROMOSOME TEMPLATE REPAIR
| US 20220325338 | Bier et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ethan Bier (San Diego, California); Annabel Guichard (La Jolla, California); Zhiqian Li (San Diego, California) |
| ABSTRACT | Provided herein are systems and methods for performing repair of mutant chromosomes in cells by using the homologous chromosome as a template for homology directed repair. Also provided herein are CopyCatcher systems, methods, and organisms for the study and measurement of homologous chromosome template repair and related mechanisms in cells and organisms. |
| FILED | Friday, April 01, 2022 |
| APPL NO | 17/711793 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/907 (20130101) C12N 15/8509 (20130101) C12N 2015/859 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) C12N 2800/105 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6858 (20130101) Original (OR) Class C12Q 1/6897 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220325342 | Giresi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul Giresi (Palo Alto, California); Jason D. Buenrostro (Redwood City, California); Howard Y. Chang (Stanford, California); William J. Greenleaf (Menlo Park, California) |
| ABSTRACT | Provided herein is a method for analyzing polynucleotides such as genomic DNA. In certain embodiments, the method comprises: (a) treating chromatin isolated from a population of cells with an insertional enzyme complex to produce tagged fragments of genomic DNA; (b) sequencing a portion of the tagged fragments to produce a plurality of sequence reads; and (c) making an epigenetic map of a region of the genome of the cells by mapping information obtained from the sequence reads to the region. A kit for performing the method is also provided. |
| FILED | Monday, June 06, 2022 |
| APPL NO | 17/833686 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6869 (20130101) C12Q 1/6874 (20130101) Original (OR) Class C12Q 2521/301 (20130101) C12Q 2537/164 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) G16B 30/00 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220325343 | Velculescu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Victor E. Velculescu (Glenwood, Maryland); Stephen Cristiano (Baltimore, Maryland); Alessandro Leal (Baltimore, Maryland); Jillian A. Phallen (Baltimore, Maryland); Jacob Fiksel (Baltimore, Maryland); Vilmos Adleff (Baltimore, Maryland); Robert B. Scharpf (Baltimore, Maryland) |
| ABSTRACT | This document relates to methods and materials for assessed, monitored, and/or treated mammals (e.g., humans) having cancer. For example, methods and materials for identifying a mammal as having cancer (e.g., a localized cancer) are provided. For example, methods and materials for assessing, monitoring, and/or treating a mammal having cancer are provided. |
| FILED | Friday, June 17, 2022 |
| APPL NO | 17/842893 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1068 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6874 (20130101) Original (OR) Class C12Q 1/6886 (20130101) C12Q 2600/156 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 30/00 (20190201) G16B 40/00 (20190201) G16B 40/20 (20190201) G16B 40/30 (20190201) G16B 50/20 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220326080 | Yun et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Seok-Hyun Yun (Boston, Massachusetts); Amira Eltony (Boston, Massachusetts); Desmond Chow Ming Chia (Boston, Massachusetts) |
| ABSTRACT | Systems and methods are provided for analyzing a biomechanical property of a medium using stimulated Brillouin scattering microscopy. The method can include a first step of applying a probe beam and pulsed pump beam to a target section of the medium, wherein the pump beam interacts with the probe beam to generate at least one acoustic wave in the medium and at least one Brillouin signal is produced as a result of the generated acoustic wave. The method can also include a second step of receiving the produced Brillouin signal and a third step of determining, using a processor and the |
| FILED | Wednesday, June 03, 2020 |
| APPL NO | 17/615991 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/4412 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/636 (20130101) G01N 2021/638 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/108 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220326215 | Franklin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aaron D. Franklin (Cary, North Carolina); Nicholas X. D. Williams (Washington, District of Columbia); Brittani L. Carroll (Durham, North Carolina); Steven G. Noyce (Durham, North Carolina) |
| ABSTRACT | A fully-printed sensor chip for measuring prothrombin time of a blood sample. The sensor chip includes a pair of electrodes and a pair of contact pads, each electrically coupled to a different one of the electrodes, printed on the surface of the substrate using conductive ink materials. When a blood sample is placed on the sample chip in contact with both electrodes, an impedance of the blood sample is determined based on a measured impedance between the two contact pads. As the blood sample clots, the impedance value changes and the prothrombin time for the blood sample is determined based on a measurement time of a maximum impedance value. A resistive bridge printed on the substrate surface between the contact pads increases a baseline measurement for the sensor chip to a value within a range that is measurable by lower-cost measurement equipment. |
| FILED | Friday, April 08, 2022 |
| APPL NO | 17/716163 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/86 (20130101) G01N 33/4905 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220326216 | YOUNGBLOOD et al. |
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| FUNDED BY |
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| APPLICANT(S) | ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. (Memphis, Tennessee) |
| ASSIGNEE(S) | ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. (Memphis, Tennessee) |
| INVENTOR(S) | Benjamin YOUNGBLOOD (Memphis, Tennessee); Jeremy CRAWFORD (Memphis, Tennessee); Yiping FAN (Memphis, Tennessee); Caitlin ZEBLEY (Memphis, Tennessee); Stephen GOTTSCHALK (Germantown, Tennessee); Giedre KRENCIUTE (Memphis, Tennessee); Christopher PETERSEN (Memphis, Tennessee) |
| ABSTRACT | The application provides T cell gene expression signatures that can be used to predict T cell therapy outcomes. |
| FILED | Wednesday, April 08, 2020 |
| APPL NO | 17/608079 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Peptides C07K 14/705 (20130101) Enzymes C12Y 201/01037 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/505 (20130101) Original (OR) Class G01N 33/5023 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220326217 | Wambre et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Benaroya Research Institute at Virginia Mason (Seattle, Washington) |
| ASSIGNEE(S) | Benaroya Research Institute at Virginia Mason (Seattle, Washington) |
| INVENTOR(S) | Eric E. Wambre (Seattle, Washington); Justine J. Calise (Seattle, Washington) |
| ABSTRACT | Provided are methods and compositions for labeling an allergen-specific pathogenic CD4+ T-cell. The method can comprise contacting a cell population comprising CD4+ T cells with a suspected allergen to provide a challenged cell population, contacting the challenged cell population, or a subpopulation thereof, with a first molecule that specifically binds to a biomarker for an allergen-specific pathogenic T cell, wherein binding of the first molecule to the biomarker on a CD4+ cell indicates the cell is an allergen-specific pathogenic CD4+ T cell, and detecting binding of the first molecule to a CD4+ cell, wherein binding to the cell indicates the cell is an allergen-specific pathogenic CD4+ T cell. The method is applicable to monitoring the presence of allergen-specific pathogenic CD4+ T cells and/or efficacy of immunotherapy for allergies in a subject. |
| FILED | Friday, September 04, 2020 |
| APPL NO | 17/640548 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/08 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/505 (20130101) Original (OR) Class G01N 33/6893 (20130101) G01N 2333/7155 (20130101) G01N 2800/24 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220326218 | Sanchez et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yolanda Sanchez (Orford, New Hampshire); Stephanie Joy Bouley (North Smithfield, Rhode Island) |
| ABSTRACT | Disclosed herein are methods and compositions useful for identification of potential therapeutic agents for the treatment of a NF1- or RAS-associated disorder. Disclosed herein are also methods and compositions useful for the treatment of a NF1- or RAS-associated disorder. |
| FILED | Thursday, September 10, 2020 |
| APPL NO | 17/641877 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/025 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5011 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220326229 | van Rijn et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Richard M. van Rijn (Fremont, California); Alexander R. French (West Lafayette, Indiana); Yazan Jamal Ibrahim Meqbil (West Lafayette, Indiana) |
| ABSTRACT | Assay for real-time simultaneous recruitment of arrestin isoforms (e.g., β-arrestin), to a receptor, such as a G protein-coupled receptor (e.g., DOR); a biosensor; a bioarray; and a kit. |
| FILED | Wednesday, February 02, 2022 |
| APPL NO | 17/591461 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/542 (20130101) Original (OR) Class G01N 33/566 (20130101) G01N 2333/726 (20130101) G01N 2500/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220326233 | DUTTA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Wyoming (Laramie, Wyoming) |
| ASSIGNEE(S) | University of Wyoming (Laramie, Wyoming) |
| INVENTOR(S) | Debashis DUTTA (Laramie, Wyoming); Michael TAYLOR (Laramie, Wyoming); Ravichander Rao PEESARA (Laramie, Wyoming) |
| ABSTRACT | In one embodiment, the present invention includes a system for detecting a target analyte which includes a microfluidic device having least one microfluidic channel with a binding surface positioned in the microfluidic channel with further include a first electrode and a second electrode. The system may further include a detector and a voltage supply. Also included is a method to detect a target analyte using a described microfluidics device, introducing solution with a target analyte to a binding surface, and binding the target analyte to the binding surface by applying an electrical potential between the first and second electrodes during at least a portion of the binding step, which enhances the rate of binding of the target analyte molecules to the binding molecules. The method then includes the steps of detecting a reporter molecule which corresponds to the amount of the bound target analyte molecules, which correlates with the amount of target analyte in the original sample. The method may also include multiple applications of sample to the binding surface prior to the detection step. |
| FILED | Monday, April 18, 2022 |
| APPL NO | 17/722945 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502776 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/76 (20130101) G01N 33/54306 (20130101) G01N 33/54366 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220326236 | Achkar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Albert Einstein College of Medicine (Bronx, New York) |
| ASSIGNEE(S) | Albert Einstein College of Medicine (Bronx, New York) |
| INVENTOR(S) | Jacqueline M. Achkar (Brooklyn, New York); Eustache Paramithiotis (Montreal, Canada) |
| ABSTRACT | This disclosure describes markers that are associated with active tuberculosis (TB) and demonstrates that the disclosed markers can be used as a biomarker for determining whether a subject has or is at risk of having active TB and for the early detection of HIV-associated TB. This disclosure also provides methods of screening subjects who are thought to be at risk for developing active TB, methods of determining the efficacy of therapeutic regimens for preventing or treating active TB, and methods of identifying anti-TB agents. |
| FILED | Friday, October 02, 2020 |
| APPL NO | 17/764693 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5695 (20130101) Original (OR) Class G01N 33/6893 (20130101) G01N 2800/56 (20130101) G01N 2800/60 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220326241 | Ellis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Baylor College of Medicine (Houston, Texas); The Broad Institute, Inc. (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew J. Ellis (Houston, Texas); Bing Zhang (Houston, Texas); Eric Jaehnig (Houston, Texas); Steven Carr (Cambridge, Massachusetts); Shankha Satpathy (Cambridge, Massachusetts); Michael Gillette (Boston, Massachusetts) |
| ABSTRACT | Methods disclosed herein concern cancer proteogenomics, which integrates genomics, transcriptomics and mass spectrometry (MS)-based proteomics to gain insights into cancer biology and treatment efficacy. To promote clinical utility of embodiments herein, proteogenomics approaches were developed for frozen core needle biopsies using tissue-sparing specimen processing with or without a microscaled proteomics workflow. |
| FILED | Wednesday, August 12, 2020 |
| APPL NO | 17/634218 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6848 (20130101) G01N 33/57415 (20130101) Original (OR) Class G01N 2440/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220326495 | Buckland et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | LighTopTech Corp. (West Henrietta, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric L. Buckland (Hickory, North Carolina); Cristina Canavesi (West Henrietta, New York) |
| ABSTRACT | A low-coherence interferometry imaging system for imaging translucent samples, wherein the system includes an optical coherence microscopy (OCM) mode and an optical coherence tomography (OCT) mode, and wherein the system can selectively employ either mode without requiring re-positioning of a sample under test. The system provides for the selective disposition of the OCM mode or the OCT mode in an optical path intermediate a scanning system and an imaging objective. |
| FILED | Monday, August 09, 2021 |
| APPL NO | 17/397557 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 21/0056 (20130101) Original (OR) Class G02B 21/361 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220326502 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Jonathan T.C. Liu (Seattle, Washington); Lindsey A. Barner (Seattle, Washington); Adam K. Glaser (Seattle, Washington) |
| ABSTRACT | Apparatuses, systems, and methods for solid immersion meniscus lenses (STMlenses). An optical system may include a sample holder with a first side which supports a sample, and a second side opposite the first side. The second side of the sample holder may be in contact with an immersion fluid. Light passing between the sample and an objective lens may pass through the sample holder, immersion fluid, and a SIMlens positioned between the immersion fluid and objective. The SIMlens may have a first curved surface and a second curved surface, each of which may be shaped to match a wavefront of the light as it passes through the SIMlens. The immersion fluid, SIMlens, and environment containing the objective may all have different refractive indices. |
| FILED | Thursday, February 24, 2022 |
| APPL NO | 17/680033 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 21/26 (20130101) G02B 21/0032 (20130101) G02B 21/33 (20130101) Original (OR) Class G02B 21/248 (20130101) G02B 21/367 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220327238 | Bi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xuan Bi (Minneapolis, Minnesota); Xiaotong Shen (Minneapolis, None) |
| ABSTRACT | A method includes storing a value in data storage so that a third party is prevented from accessing the value, retrieving the value and applying a first transform to the value to form a transformed value having a uniform distribution. Noise is added to the transformed value to form a sum and a second transform is applied to the sum to form a transformed sum having a uniform distribution. An inverse of the first transform is applied to the transformed sum to form a privatized value and the privatized value is provided to the third party. |
| FILED | Thursday, March 31, 2022 |
| APPL NO | 17/710145 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/6254 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220327693 | Kim et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hyun Kim (Los Angeles, California); Yu Shi (Fremont, California); Jonathan Gerald Goldin (Oakland, California); Weng Kee Wong (Oakland, California) |
| ABSTRACT | A method for training a machine learning algorithm that classifies predictive regions-of interest (“ROI”) of progression of idiopathic pulmonary fibrosis. The method includes acquiring a set of computed tomography (CT) images of a plurality of patients and selecting a plurality of ROIs within the set of images. Each of the ROIs designates a label that indicates progression of pulmonary fibrosis and training a machine learning algorithm by inputting the plurality of ROIs and the associated labels into the algorithm. The algorithm identifies the ROIs in the set of images as indicating regions of pulmonary fibrosis within the set of images based on the features. |
| FILED | Thursday, September 03, 2020 |
| APPL NO | 17/639511 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0037 (20130101) A61B 5/7267 (20130101) A61B 5/7275 (20130101) A61B 6/032 (20130101) A61B 6/5217 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 2207/10081 (20130101) G06T 2207/30101 (20130101) Image or Video Recognition or Understanding G06V 10/25 (20220101) G06V 10/7715 (20220101) G06V 2201/03 (20220101) G06V 2201/07 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220327954 | MARGOLIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Gayla MARGOLIN (Los Angeles, California); Adela C. AHLE (San Francisco, California); Matthew William AHLE (San Francisco, California); Theodora CHASPARI (College Station, California); Shrikanth Sambasivan NARAYANAN (Santa Monica, California) |
| ASSIGNEE(S) | University of Southern California (Los Angeles, California) |
| INVENTOR(S) | Gayla MARGOLIN (Los Angeles, California); Adela C. AHLE (San Francisco, California); Matthew William AHLE (San Francisco, California); Theodora CHASPARI (College Station, California); Shrikanth Sambasivan NARAYANAN (Santa Monica, California) |
| ABSTRACT | A method for promoting interpersonal interactions includes a step of receiving data streams from a plurality of mobile smart devices from a plurality of users, the data streams recording information about users' daily lives. Intervention signals are sent to a user in response to data acquired from two or more individuals and interpreted with respect to user internal states, moods, emotions, predetermined behaviors, and interactions with other users. |
| FILED | Monday, June 27, 2022 |
| APPL NO | 17/849996 |
| CURRENT CPC | Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 19/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220327962 | Moore et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason Z. Moore (State College, Pennsylvania); Scarlett Miller (State College, Pennsylvania); Dailen Brown (State College, Pennsylvania); Haroula Tzamaras (State College, Pennsylvania); Jessica M. González-Vargas (State College, Pennsylvania); E. David C. Han (Hummelstown, Pennsylvania) |
| ABSTRACT | A medical training system is provided having a housing, a phantom tissue simulant surface, an insertion hole, at least one medical instrument with a tip configured to pierce the phantom tissue simulant surface, a passage, at least one sensor, and a microprocessor. The system simulate a medical training procedure and the microprocessor is configured to read and process information from each of the at least one sensor in order to provide feedback to a user. |
| FILED | Friday, April 08, 2022 |
| APPL NO | 17/716543 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 34/25 (20160201) A61B 2562/0223 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 23/30 (20130101) G09B 23/285 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220327963 | Tatum et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Iowa Research Foundation (Iowa City, Iowa) |
| ASSIGNEE(S) | University of Iowa Research Foundation (Iowa City, Iowa) |
| INVENTOR(S) | Marcus Tatum (Iowa City, Iowa); Geb W. Thomas (Iowa City, Iowa) |
| ABSTRACT | A system for simulating surgery includes an electromagnetic tracking system comprising an emitter and a plurality of electromagnetic sensors and a plurality of model bone fragments, each of the model bone fragments operatively connected to one of the plurality of electromagnetic sensors. A method for simulating surgery includes electromagnetically tracking position of a plurality of model bone fragments and a model bone shaft using an electromagnetic tracking system and displaying virtual fluoroscopic images based on sensed position of the model bone fragments and the model bone shaft. |
| FILED | Friday, June 24, 2022 |
| APPL NO | 17/848810 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/0206 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 9/00 (20130101) G09B 23/30 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220328141 | GEDECK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Collaborative Drug Discovery, Inc. (Burlingame, California) |
| ASSIGNEE(S) | Collaborative Drug Discovery, Inc. (Burlingame, California) |
| INVENTOR(S) | Peter GEDECK (Arlington, Virginia); Barry A. BUNIN (Belmont, California); Michael BOWLES (Redwood City, California); Philip CHEUNG (San Diego, California); Alex Michael CLARK (Montreal, Canada) |
| ABSTRACT | A method includes generating a graph of a chemical compound based on at least one of an order-dependent representation of the chemical compound and a molecular graph representation of the chemical compound, encoding the graph based on an adjacency matrix of a graph convolutional neural network (GCN), an activation function of the GCN, and one or more weights of the GCN to generate a latent vector representation of the chemical compound, and decoding the latent vector representation based on a plurality of hidden states of a neural network (NN) to generate a reproduced order-dependent representation of the chemical compound. |
| FILED | Thursday, March 31, 2022 |
| APPL NO | 17/709614 |
| CURRENT CPC | Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 20/70 (20190201) Original (OR) Class G16C 20/80 (20190201) G16C 60/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220328189 | Zhou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zongwei Zhou (Tempe, Arizona); Jianming Liang (Scottsdale, Arizona) |
| ABSTRACT | Embodiments described herein include systems for implementing annotation-efficient deep learning in computer-aided diagnosis. Exemplary embodiments include systems having a processor and a memory specially configured with instructions for learning annotation-efficient deep learning from non-labeled medical images to generate a trained deep-learning model by applying a multi-phase model training process via specially configured instructions for pre-training a model by executing a one-time learning procedure using an initial annotated image dataset; iteratively re-training the model by executing a fine-tuning learning procedure using newly available annotated images without re-using any images from the initial annotated image dataset; selecting a plurality of most representative samples related to images of the initial annotated image dataset and the newly available annotated images by executing an active selection procedure based on the which of a collection of un-annotated images exhibit either a greatest uncertainty or a greatest entropy; extracting generic image features; updating the model using the generic image features extrated; and outputting the model as the trained deep-learning model for use in analyzing a patient medical image. Other related embodiments are disclosed. |
| FILED | Friday, April 08, 2022 |
| APPL NO | 17/716929 |
| CURRENT CPC | Image or Video Recognition or Understanding G06V 10/7753 (20220101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220330050 | Osinski et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | AT and T Intellectual Property I, L.P. (Atlanta, Georgia); AT and T Mobility II LLC (Atlanta, Georgia); Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | AT and T Intellectual Property I, L.P. (Atlanta, Georgia); AT and T Mobility II LLC (Atlanta, Georgia); Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Matthew Osinski (Westfield, New Jersey); JIA WANG (Basking Ridge, New Jersey); Zihui Ge (Madison, New Jersey); Anthony Caracciolo (E.Brunswick, New Jersey); Chandra Thompson (College Park, Georgia); Benjamin Grizzle (Yukon, Oklahoma); Eric Bonitz (Pueblo, Colorado); Hendrik Hofman (Danville, California); Sonia Fahmy (West Lafayette, Indiana); Chunyi Peng (West Lafayette, Indiana); Bruno Ribeiro (West Lafayette, Indiana); Amit Kumar Sheoran (West Lafayette, Indiana) |
| ABSTRACT | Aspects of the subject disclosure may include, for example, automatically detecting a service issue of a telecommunication system that may impact a customer of a telecommunication service provider of the telecommunication system, predicting, by the processing system, a future customer care interaction by the customer as a result of the service issue, initiating a resolution action of the telecommunication system for the service issue before the customer contacts a customer care agent of the telecommunication service provider, wherein the initiating is responsive to the predicting the future customer care interaction and modifying a component of the telecommunication system to improve efficiency of operation of the telecommunication system by reducing a number of customer care contacts by customers of the telecommunication service provider. Other embodiments are disclosed. |
| FILED | Wednesday, June 22, 2022 |
| APPL NO | 17/846246 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 30/016 (20130101) Telephonic Communication H04M 3/4217 (20130101) H04M 3/5175 (20130101) H04M 15/886 (20130101) Wireless Communication Networks H04W 8/18 (20130101) H04W 24/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20220323083 | FRANKLIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Prytime Medical Devices, Inc. (Boerne, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Curtis J. FRANKLIN (Lakewood, Colorado); Todd J. KRUMMENACHER (Lakewood, Colorado); Jeremy REYNOLDS (Lakewood, Colorado); David SPENCER (Boerne, Texas); Luke William FISHER (Lakewood, Colorado) |
| ABSTRACT | An occlusion catheter system includes an inflation catheter member and an occlusion balloon. The proximal and distal balloon ends are connected to the inflation catheter between the proximal and distal catheter ends. A distal pressure sensor is attached to the inflation catheter member between the proximal balloon end and the atraumatic tip. An inflatable spine is connected to the inflation catheter. The proximal spine end is connected to the inflation catheter near the proximal balloon end and the distal spine end is connected to the inflation catheter near the distal balloon end. The occlusion balloon and the inflatable spine are configured to define blood flow channels with the internal surface and the external balloon surface when the occlusion catheter system is at least partially positioned in the vessel and the occlusion balloon and the inflatable spine are in a partially inflated configuration. |
| FILED | Friday, January 21, 2022 |
| APPL NO | 17/581134 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/12036 (20130101) A61B 17/12109 (20130101) A61B 17/12136 (20130101) Original (OR) Class A61B 2017/22051 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 25/00 (20130101) A61M 25/02 (20130101) A61M 25/10 (20130101) A61M 25/0068 (20130101) A61M 25/104 (20130101) A61M 25/1002 (20130101) A61M 25/1011 (20130101) A61M 25/10184 (20131105) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220323641 | ALVAREZ et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Theradaptive, Inc. (Frederick, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Luis ALVAREZ (Lexington, Massachusetts); Todd HEIL (Lexington, Massachusetts) |
| ABSTRACT | The present disclosure provides devices comprising a therapeutic agent bound to a printed three-dimensional structure. The printed three-dimensional structure comprises about 50% to about 100% by weight ceramic and about 0% to about 50% by weight N polymer. Ink formulations for three-dimensional printing are also disclosed. Additionally, provided herein are methods for manufacturing devices and uses thereof, e.g., in treating a condition in a subject in need thereof. |
| FILED | Wednesday, August 19, 2020 |
| APPL NO | 17/636527 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/08 (20130101) A61K 38/10 (20130101) A61K 38/1709 (20130101) A61K 38/1808 (20130101) A61K 38/1825 (20130101) A61K 38/1858 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/10 (20130101) Original (OR) Class A61L 27/54 (20130101) A61L 27/56 (20130101) A61L 27/425 (20130101) A61L 2300/414 (20130101) A61L 2430/02 (20130101) A61L 2430/38 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220324096 | Penn |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | James Douglass Penn (Cambridge, Mississippi) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Douglass Penn (Cambridge, Mississippi) |
| ABSTRACT | A system and method for a planar positioning system for an output member, the system having a pair of x-coordinate linear carriages and a pair of y-coordinate linear carriages. The system has a guide mechanism for the pair of x-coordinate linear carriages and the pair of y-coordinate linear carriages. The system has a plurality of movement and constraining cables extending from the pair of x-coordinate linear carriages and the pair of y-coordinate linear carriages to the output member for driving the output, wherein the pair of x-coordinate linear carriages and the output member move in sync in the x-direction and the pair of y-coordinate linear carriages and the output member move in sync in the y-direction. A restraint mechanism restrains the output member in an additional degree of freedom besides the x- and y-directions. The restraint can be a cable uptake and release device. |
| FILED | Thursday, April 28, 2022 |
| APPL NO | 17/731705 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/023 (20130101) Original (OR) Class B25J 9/026 (20130101) B25J 9/1045 (20130101) Gearing F16H 2019/069 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 901/21 (20130101) Technical Subjects Covered by Former US Classification Y10T 74/20341 (20150115) Y10T 74/20354 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220324206 | Hockemeyer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Hockemeyer (Saratoga Springs, New York); Jason David Shapiro (Methuen, Massachusetts); K.M.K. Genghis Khan (Niskayuna, New York); James Scott Vartuli (Rexford, New York); Daniel Gene Dunn (Guilderland, New York); Shatil Sinha (Clifton Park, New York); Douglas Decesare (Queensbury, New York); Suresh Subramanian (Mason, Ohio) |
| ABSTRACT | Ceramic matrix composite articles include, for example a first plurality of plies of ceramic fibers in a ceramic matrix defining a first extent, and a local at least one second ply in said ceramic matrix defining a second extent on and/or in said first plurality of plies with the second extent being less than said first extent. The first plurality of plies has a first property, the at least one second ply has at least one second property, and said first property being different from said at least one second property. The different properties may include one or more different mechanical (stress/strain) properties, one or more different thermal conductivity properties, one or more different electrical conductivity properties, one or more different other properties, and combinations thereof. |
| FILED | Tuesday, June 28, 2022 |
| APPL NO | 17/851241 |
| CURRENT CPC | Shaping Clay or Other Ceramic Compositions; Shaping Slag; Shaping Mixtures Containing Cementitious Material, e.g Plaster B28B 1/522 (20130101) B28B 11/08 (20130101) Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 18/00 (20130101) Original (OR) Class B32B 2262/105 (20130101) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/80 (20130101) C04B 35/565 (20130101) C04B 35/571 (20130101) C04B 35/6267 (20130101) C04B 35/62884 (20130101) C04B 37/001 (20130101) C04B 2235/614 (20130101) C04B 2235/3826 (20130101) C04B 2235/5244 (20130101) C04B 2235/9607 (20130101) C04B 2237/38 (20130101) C04B 2237/584 (20130101) Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/005 (20130101) F01D 5/282 (20130101) F01D 9/02 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2230/31 (20130101) F05D 2300/6033 (20130101) Generating Combustion Products of High Pressure or High Velocity, e.g Gas-turbine Combustion Chambers F23R 3/007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220324557 | Messinger et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | AVX Aircraft Company (Benbrook, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stan Messinger (Hurst, Texas); Clayton Messinger (Grapevine, Texas) |
| ABSTRACT | A shaft assembly (which may be a rotor mast for a rotorcraft) may include a shaft body formed with composite material and one or more metal fittings attached to the shaft body. A metal fitting may include an interior opening with a cross-section having a non-circular perimeter (such as an oval or an ellipse). The interior opening may also include contouring, such as a first tapered section in which the fitting converges toward the longitudinal axis of the shaft body and a second tapered section in which the fitting diverges from the longitudinal axis. |
| FILED | Thursday, January 20, 2022 |
| APPL NO | 17/580392 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 27/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220324562 | Kleveland et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rockwell Collins, Inc. (Cedar Rapids, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Kleveland (Marion, Iowa); Korey Breger (Coralville, Iowa) |
| ABSTRACT | A computer apparatus includes a touchscreen display. The computer apparatus generates a graphical user interface on the touchscreen display and receive user inputs via the touchscreen display. The graphical user interface includes symbology representing multiple unmanned teamed assets, a primary command and control asset currently controlling the unmanned teamed assets, and one or more secondary command and control assets not currently controlling the unmanned teamed asset. By the touchscreen display, an operator selects one of the secondary command and control assets for transferring control. The computer apparatus may be coupled with either the primary or the secondary command and control asset. The computer apparatus may initiate the transfer request. Similarly, the computer apparatus may receive the transfer request and confirm transfer. |
| FILED | Tuesday, April 13, 2021 |
| APPL NO | 17/229456 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 39/022 (20130101) B64C 39/024 (20130101) Original (OR) Class B64C 2201/146 (20130101) Electric Digital Data Processing G06F 3/04817 (20130101) G06F 3/04886 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220324758 | PETERS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam B. PETERS (Baltimore, Maryland); Michael C. BRUPBACHER (Catonsville, Maryland); Dajie ZHANG (Baltimore, Maryland); Dennis NAGLE (Ellicott City, Maryland) |
| ABSTRACT | A composite precursor powder, including one or more metals or metalloids, and one or more oxides, wherein a molar ratio of the one or more metals or metalloids to the one or more oxides is from about 1:0.01 to about 1:4, and wherein the molar ratio of the one or more metals or metalloids to the one or more oxides is configured according to a desired volumetric change of the composite precursor powder when converted to a non-oxide ceramic. |
| FILED | Thursday, October 01, 2020 |
| APPL NO | 17/765313 |
| CURRENT CPC | Shaping Clay or Other Ceramic Compositions; Shaping Slag; Shaping Mixtures Containing Cementitious Material, e.g Plaster B28B 1/001 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/10 (20200101) B33Y 80/00 (20141201) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/65 (20130101) C04B 35/5607 (20130101) C04B 35/5611 (20130101) Original (OR) Class C04B 2235/404 (20130101) C04B 2235/3232 (20130101) C04B 2235/3241 (20130101) C04B 2235/3839 (20130101) C04B 2235/3843 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220324902 | MCCALL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ReveraGen BioPharma, Inc. (Rockville, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John M. MCCALL (Boca Grande, Florida); Eric HOFFMAN (Rockville, Maryland); Kanneboyina NAGARAJU (Highland, Maryland); Jesse DAMSKER (Alexandria, Virginia) |
| ABSTRACT | The present invention relates to compounds and methods which may be useful as treatments of diseases. |
| FILED | Friday, December 10, 2021 |
| APPL NO | 17/548030 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/58 (20130101) A61K 31/573 (20130101) Steroids C07J 7/003 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220325129 | Fortman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PRC-Desoto International, Inc. (Sylmar, California) |
| ASSIGNEE(S) | PRC-Desoto International, Inc. (Sylmar, California) |
| INVENTOR(S) | David J. Fortman (Pittsburgh, Pennsylvania); Marvin M. Pollum, Jr. (Pittsburgh, Pennsylvania); Joseph P. Kriley (Valencia, Pennsylvania); Brian K. Rearick (Allison Park, Pennsylvania); Maria S. French (Canfield, Ohio); Masayuki Nakajima (Wexford, Pennsylvania) |
| ABSTRACT | The present invention is directed to compositions comprising a first component, a second component, and elastomeric particles. The first component comprises an epoxy-containing compound. The second component comprises a diamine comprising a cyclic ring and/or a polyamine comprising a cyclic ring. The diamine may chemically react with the epoxy-containing compound. Optionally, the cyclic ring of the diamine and/or the polyamine has at least one carbon positioned between the amino functional groups and the cyclic ring structure. Optionally, at least 50% by weight of the elastomeric particles comprise a styrene butadiene core based on total weight of the elastomeric particles. The present invention is also directed to methods of making the compositions, methods of coating a substrate, and coated substrates. |
| FILED | Tuesday, June 23, 2020 |
| APPL NO | 17/753146 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 70/00 (20141201) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 59/5033 (20130101) Compositions of Macromolecular Compounds C08L 63/00 (20130101) C08L 2205/03 (20130101) C08L 2205/025 (20130101) C08L 2207/04 (20130101) C08L 2207/53 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 163/00 (20130101) Original (OR) Class Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 163/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220325273 | FUNKNER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CureVac Real Estate GmbH (Tübingen, Germany) |
| ASSIGNEE(S) | CureVac Real Estate GmbH (Tübingen, Germany) |
| INVENTOR(S) | Andreas FUNKNER (Tübingen, Germany); Stefanie DORNER (Tübingen, Germany); Stefanie SEWING (Tübingen, Germany); Johannes KAMM (Tübingen, Germany); Norbert BROGHAMMER (Tübingen, Germany); Thomas KETTERER (Gomaringen, Germany); Thorsten MUTZKE (Reutlingen, Germany) |
| ABSTRACT | The present invention relates to method for producing and purifying RNA comprising the steps of providing DNA encoding the RNA; transcription of the DNA into RNA; and conditioning and/or purifying of the solution comprising transcribed RNA by one or more steps of tangential flow filtration (TFF). |
| FILED | Thursday, February 03, 2022 |
| APPL NO | 17/591978 |
| CURRENT CPC | Separation B01D 61/145 (20130101) B01D 71/12 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1017 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/02 (20130101) G01N 2030/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220325303 | HORWITZ et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | AMYRIS, INC. (Emeryville, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew HORWITZ (Emeryville, California); Kristy Michelle HAWKINS (Emeryville, California); Max SCHUBERT (Emeryville, California); Wayne SZETO (Emeryville, California) |
| ABSTRACT | Provided herein are methods of integrating one or more exogenous nucleic acids into one or more selected target sites of a host cell genome. In certain embodiments, the methods comprise contacting the host cell genome with one or more integration polynucleotides comprising an exogenous nucleic acid to be integrated into a genomic target site, a nuclease capable of causing a break at the genomic target site, and a linear nucleic acid capable of homologous recombination with itself or with one or more additional linear nucleic acids contacted with the population of cells, whereupon said homologous recombination results in formation of a circular extrachromosomal nucleic acid comprising a coding sequence for a selectable marker. In some embodiments, the methods further comprise selecting a host cell that expresses the selectable marker. |
| FILED | Tuesday, June 14, 2022 |
| APPL NO | 17/840369 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) C12N 15/902 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2310/20 (20170501) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6897 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220325314 | UNAL |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TRITON SYSTEMS, INC. (Chelmsford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Baris UNAL (Lowell, Massachusetts) |
| ABSTRACT | Described herein is a system for detecting microbial contamination in a liquid storage container, such as a fuel storage tank or a water storage tank. The system can include one or more impedance sensor arrays positioned within the fuel storage container and a computer system coupled to the impedance sensor arrays. The computer system configured to detect microbial growth within the fuel storage container based on changes in impedance across the impedance sensor array. The system can be embodied as a standalone system or can be incorporated into the fuel tank's existing systems. |
| FILED | Wednesday, January 26, 2022 |
| APPL NO | 17/584779 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/04 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/028 (20130101) G01N 33/2835 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220325432 | Jariwala et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Deep Jariwala (Philadelphia, Pennsylvania); Eric Andrew Stach (Swarthmore, Pennsylvania); Pawan Kumar (Philadelphia, Pennsylvania) |
| ABSTRACT | Provided are novel transition metal dichalcogenides having a platelet structure and comprising a 2H phase region and/or a 3R phase region. The platelets exhibit a narrow size distribution and comparatively high surface area and edge area, which characteristics render the platelets especially suitable for catalysis applications, as well as use in electronic devices. Also provided are methods of synthesizing the disclosed transition metal dichalcogenide platelets. |
| FILED | Friday, February 18, 2022 |
| APPL NO | 17/674964 |
| CURRENT CPC | Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 39/00 (20130101) Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 1/023 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220325489 | Miller et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Colt T. Miller (Bloomington, Indiana); Sean P Gish (Bedford, Indiana) |
| ABSTRACT | Provided is a flood barrier for use with HAZMAT materials. The barrier includes a first wall and a second wall joined together at a first end, tape for securing the barrier to a surface to prevent leaks, multiple flexible ribs attached between the first wall and second walls, one or more holes for filling, and a rod that separates an open end of the first and second wall to form a chamber with an open end. Several insulating floats are evenly spaced between the ribs on a bottom surface of the first wall to prevent overflow. A gap filler, such as uncured silicone and tape is used in the transition from a terminal rib to an exposed corner of the barrier. The barrier can withstand high heat for a sustained period of time, is leak-proof, and includes an improved method of sealing corners. |
| FILED | Wednesday, January 19, 2022 |
| APPL NO | 17/578657 |
| CURRENT CPC | Hydraulic Engineering E02B 3/106 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220325890 | Dai et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Raytheon Technologies Corporation (Farmington, Connecticut) |
| ASSIGNEE(S) | Raytheon Technologies Corporation (Farmington, Connecticut) |
| INVENTOR(S) | Zhongtao Dai (West Hartford, Connecticut); Peter AT Cocks (South Glastonbury, Connecticut) |
| ABSTRACT | A combustor for a rotating detonation engine includes a radially outer wall extending along an axis (A); a radially inner wall extending along the axis (A), wherein the radially inner wall is positioned within the radially outer wall to define an annular detonation chamber having an inlet for fuel and oxidant and an outlet; a first passage for feeding at least one of the fuel and the oxidant along a first passage axis (a1) to the inlet; a second passage for feeding at least one of the fuel and the oxidant along a second passage axis (a2) to the inlet, wherein the second passage axis is arranged at an angle (α) relative to the first passage axis whereby mixing of flow from the first passage and the second passage is induced. |
| FILED | Thursday, April 08, 2021 |
| APPL NO | 17/225500 |
| CURRENT CPC | Generating Combustion Products of High Pressure or High Velocity, e.g Gas-turbine Combustion Chambers F23R 3/06 (20130101) Original (OR) Class F23R 3/50 (20130101) F23R 3/56 (20130101) F23R 3/286 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220325973 | Peters et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Boeing Company (Chicago, Illinois) |
| ASSIGNEE(S) | The Boeing Company (Chicago, Illinois) |
| INVENTOR(S) | Garrett B. Peters (St. Louis, Missouri); Lucian Woods (Florissant, Missouri); Robert R. Johnson (Kirkwood, Missouri); Daniel E. Pulcher (St. Charles, Missouri); Anthony C. Roberts (St. Paul, Missouri) |
| ABSTRACT | A plug for insertion into a blast-tube exit cavity of a gun-blast diffuser comprises a plug front surface, a plug rear surface, a plug side surface that extends between the plug front surface and the plug rear surface, a body, comprising a polyurethane foam, and a substrate, coupled to the body and comprising a conductive nonwoven fabric, impregnated with a polyurethane matrix. The plug front surface of the plug is formed by the substrate. The plug rear surface of the plug is formed by the body. The plug side surface of the plug is formed by the substrate and the body. |
| FILED | Monday, September 27, 2021 |
| APPL NO | 17/485791 |
| CURRENT CPC | Functional Features or Details Common to Both Smallarms and Ordnance, e.g Cannons; Mountings for Smallarms or Ordnance F41A 21/38 (20130101) Original (OR) Class F41A 23/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220326069 | HAN |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| ASSIGNEE(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| INVENTOR(S) | Ming HAN (Okemos, Michigan) |
| ABSTRACT | A system, apparatus, and method for demodulation of a fiber optic sensor is provided. An aspect of the system provides an optical fiber, a laser, a phase modulator configured to be coupled to the optical fiber, and a sensor. The laser emits a laser beam into the optical fiber. The phase modulator receives the laser beam from the laser and directs the laser beam to the sensor. The sensor includes a coiled portion of the optical fiber, uncoiled segments adjacent the coiled portion, and at least two fiber Bragg gratings configured to be coupled to opposite uncoiled segments adjacent the coiled portion of the optical fiber. The sensor system may further include a photodetector configured to receive a reflected portion of the laser beam from the sensor. The reflected portion is divided into at least two paths where at least two sub-outputs are generated for demodulation and sensing. |
| FILED | Wednesday, March 23, 2022 |
| APPL NO | 17/702130 |
| CURRENT CPC | Measuring Not Specially Adapted for a Specific Variable; Arrangements for Measuring Two or More Variables Not Covered in a Single Other Subclass; Tariff Metering Apparatus; Measuring or Testing Not Otherwise Provided for G01D 5/35306 (20130101) Measurement of Mechanical Vibrations or Ultrasonic, Sonic or Infrasonic Waves G01H 9/004 (20130101) Original (OR) Class Optical Elements, Systems, or Apparatus G02B 6/4215 (20130101) Transmission H04B 10/564 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220326071 | Lal |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amit Lal (Ithaca, New York) |
| ABSTRACT | A device configured for low-energy ultrasonic 2D Fourier transform analysis, comprising: (i) a first layer comprising an array of piezoelectric pixels; (ii) a second layer comprising an array of piezoelectric pixels; (iii) a third layer, positioned between the first and second layers, comprising a bulk ultrasonic transmission medium; wherein the second layer of array of piezoelectric pixels is in the Fourier plane of an input signal of the first layer array of piezoelectric pixels. |
| FILED | Friday, April 15, 2022 |
| APPL NO | 17/721882 |
| CURRENT CPC | Measurement of Mechanical Vibrations or Ultrasonic, Sonic or Infrasonic Waves G01H 11/08 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/46 (20130101) G01N 2291/0426 (20130101) Electric Digital Data Processing G06F 17/142 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 41/18 (20130101) H01L 41/083 (20130101) Transmission H04B 11/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220326086 | Bloom |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Systems and Technology Research, LLC (Woburn, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott Bloom (Encinitas, California) |
| ABSTRACT | An interferometer for use in remote sensing systems includes a beam splitter that separates an input wave into a reflected wave, which travels along a first optical path within an upper interferometer arm, and a transmitted wave, which travels along a second optical path within a lower interferometer arm. The reflected and transmitted waves are subsequently recombined by the beam splitter for imaging onto a sensor. A highly dispersive element is incorporated into at least one of the pair of interferometer arms. Due to anomalous dispersion, a frequency shift in a wave transmitted through a dispersive element changes the optical path length within its corresponding arm. As a result, the recombined wave produces an interference pattern with a measurable phase change that can be utilized to calculate the original frequency shift in the input wave with great precision and potential sub-Hertz sensitivity. |
| FILED | Wednesday, March 23, 2022 |
| APPL NO | 17/701847 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 9/0246 (20130101) Original (OR) Class G01J 2009/0226 (20130101) G01J 2009/0253 (20130101) Optical Elements, Systems, or Apparatus G02B 5/3083 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220326175 | Azoulay et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Jason Azoulay (Hattiesburg, Mississippi); Joshua Tropp (Hattiesburg, Mississippi); Vikash Kaphle (Hattiesburg, Mississippi); Anthony Benasco (Hattiesburg, Mississippi); Amar Flood (Bloomington, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason Azoulay (Hattiesburg, Mississippi); Joshua Tropp (Hattiesburg, Mississippi); Vikash Kaphle (Hattiesburg, Mississippi); Anthony Benasco (Hattiesburg, Mississippi); Amar Flood (Bloomington, Indiana) |
| ABSTRACT | A semiconductor sensor device for detecting an analyte including a semiconducting layer, one or more organic molecules in the semiconducting layer, and one or more receptor molecules, comprising a poly-cyanostilbene macrocycle, wherein the one or more receptors is embedded within or onto the semiconducting layer of the semiconductor sensor device. Also disclosed is a method of preparing the semiconductor sensor device including a step of coupling the one or more receptor molecules into or onto the semiconducting layer of the semiconductor sensor device, a dielectric surface, or an electrode surface. Also described is chemical sensing device including the semiconductor sensor device and other elements of a sensing device. |
| FILED | Thursday, November 04, 2021 |
| APPL NO | 17/519083 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/414 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/05 (20130101) H01L 51/0036 (20130101) H01L 51/0043 (20130101) H01L 51/0056 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220326180 | Cooks et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Graham Cooks (West Lafayette, Indiana); Nicolás M. Morato (West Lafayette, Indiana); Dylan T. Holden (West Lafayette, Indiana) |
| ABSTRACT | The invention generally relates to high-throughput label-free enzymatic bioassays using desorption electrospray ionization-mass spectrometry (DESI-MS). |
| FILED | Wednesday, June 22, 2022 |
| APPL NO | 17/846923 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/64 (20130101) G01N 27/622 (20130101) Original (OR) Class G01N 27/626 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/0409 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220326244 | Fantl et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Boardof Trustees of the Leland Stanford Junort University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wendy Fantl (Emeryville, California); Veronica D. Gonzalez (Stanford, California) |
| ABSTRACT | Acquisition of CD9 protein on the cell surface of NK cells confers an immunosuppressive phenotype to the NK cells, making them less effective in immunotherapy. CD9 can be transferred from tumor cells to NK cells present in the tumor environment through the process of trogocyotosis. Methods of enhancing NK cell anti-tumor activity can include evaluating NK receptor ligand expression within the tumor microenvironment(s) for patients eligible to receive NK cell immunotherapy. |
| FILED | Thursday, August 13, 2020 |
| APPL NO | 17/640283 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5047 (20130101) G01N 33/57449 (20130101) Original (OR) Class G01N 2333/70596 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220326257 | MUELLER |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. (Bethesda, Maryland) |
| ASSIGNEE(S) | THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. (Bethesda, Maryland) |
| INVENTOR(S) | Gregory P. MUELLER (Silver Spring, Maryland) |
| ABSTRACT | Described herein are deiminated proteins that are deiminated in response to oxygen-deprivation brain injury (ODBI) and/or oxygen-deprivation causing injury (ODCI). Also described are related methods and devices for detecting, diagnosing, and monitoring ODBI or ODCI, and methods for treating ODBI or ODCI. |
| FILED | Tuesday, April 30, 2019 |
| APPL NO | 17/051857 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/533 (20130101) G01N 33/6896 (20130101) Original (OR) Class G01N 2800/52 (20130101) G01N 2800/2871 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220326289 | Anderson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rydberg Technologies Inc. (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David A. Anderson (Ann Arbor, Michigan); Georg A. Raithel (Ann Arbor, Michigan); Eric G. Paradis (Ann Arbor, Michigan); Rachel E. Sapiro (Ann Arbor, Michigan) |
| ABSTRACT | Methods and apparatus for sensing or measuring an electromagnetic field. The method entails excitation into a distribution of Rydberg states of atoms of a gas occupying a test volume coextensive with the electromagnetic field. Transmission along a path traversing the test volume of at least one probe beam of electromagnetic radiation is measured at one or more frequencies overlapping a spectral feature, and a physical characteristic of the electromagnetic field is derived on the basis of variation of the spectral feature. In various embodiments, the electromagnetic field may be place in interferometric relation with another electromagnetic field. Time-varying electric field amplitude, frequency, phase and noise spectral distribution may be measured, and thus AM and FM modulated fields, as well as magnetic fields of about 1 Tesla. The apparatus for measuring the electromagnetic field may be unilaterally coupled to a probe field and detector or array of detectors. |
| FILED | Monday, June 13, 2022 |
| APPL NO | 17/838954 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 29/0878 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220326356 | Nootz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Gero Nootz (Slidell, Louisiana); Walter Britton (Lox, Florida); Fraser Dalgleish (Vero Beach, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gero Nootz (Slidell, Louisiana); Walter Britton (Lox, Florida); Fraser Dalgleish (Vero Beach, Florida) |
| ABSTRACT | An omnidirectional imaging system includes a housing have at least one transparent portion, a light source configured to produce emitted light, a transmitter configured to direct the emitted light outward of the housing through the at least one transparent portion at a 360 degree scanning angle range measured about an axis, and a receiver configured to receive the emitted light. The receiver is configured to receive the emitted light and generate a cylindrical 3D point cloud centered along a path of motion of the housing, wherein the housing moves along the axis of rotation of the emitted light. |
| FILED | Friday, April 08, 2022 |
| APPL NO | 17/716871 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/4813 (20130101) G01S 7/4817 (20130101) Original (OR) Class G01S 17/42 (20130101) G01S 17/894 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220326383 | Crouch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BLACKMORE SENSORS and ANALYTICS, LLC (Palo Alto, California) |
| ASSIGNEE(S) | BLACKMORE SENSORS and ANALYTICS, LLC (Palo Alto, California) |
| INVENTOR(S) | Stephen C. Crouch (McFarland, Wisconsin); Randy R. Reibel (Bozeman, Montana); James Curry (Bozeman, Montana); Trenton Berg (Manhattan, Montana) |
| ABSTRACT | Techniques for automatic adaptive scanning with a laser scanner include obtaining range measurements at a coarse angular resolution and forming a horizontally sorted range gate subset and a characteristic range. A fine angular resolution is determined automatically based on the characteristic range and a target spatial resolution. If the fine angular resolution is finer than the coarse angular resolution, then a minimum and maximum vertical angle is automatically determined in each horizontal slice extending a bin size from any previous horizontal slice. A set of adaptive minimum and maximum vertical angles is determined automatically by dilating and interpolating the minimum and maximum vertical angles of all the slices to the second horizontal angular resolution. A horizontal start angle, and the set of adaptive minimum and maximum vertical angles are sent to cause the ranging system to obtain measurements at the second angular resolution. |
| FILED | Thursday, January 27, 2022 |
| APPL NO | 17/586523 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 13/18 (20130101) G01S 13/343 (20130101) G01S 13/428 (20130101) G01S 13/526 (20130101) G01S 13/582 (20130101) G01S 17/42 (20130101) Original (OR) Class G01S 17/89 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220326502 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Jonathan T.C. Liu (Seattle, Washington); Lindsey A. Barner (Seattle, Washington); Adam K. Glaser (Seattle, Washington) |
| ABSTRACT | Apparatuses, systems, and methods for solid immersion meniscus lenses (STMlenses). An optical system may include a sample holder with a first side which supports a sample, and a second side opposite the first side. The second side of the sample holder may be in contact with an immersion fluid. Light passing between the sample and an objective lens may pass through the sample holder, immersion fluid, and a SIMlens positioned between the immersion fluid and objective. The SIMlens may have a first curved surface and a second curved surface, each of which may be shaped to match a wavefront of the light as it passes through the SIMlens. The immersion fluid, SIMlens, and environment containing the objective may all have different refractive indices. |
| FILED | Thursday, February 24, 2022 |
| APPL NO | 17/680033 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 21/26 (20130101) G02B 21/0032 (20130101) G02B 21/33 (20130101) Original (OR) Class G02B 21/248 (20130101) G02B 21/367 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220326821 | Kleveland et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rockwell Collins, Inc. (Cedar Rapids, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Kleveland (Marion, Iowa); Korey Breger (Coralville, Iowa) |
| ABSTRACT | A computer apparatus includes a touchscreen display. The computer apparatus generates a graphical user interface on the touchscreen display and receive user inputs via the touchscreen display. The graphical user interface includes symbology representing a flight path of multiple unmanned teamed assets from a current position to a current objective. The graphical user interface also includes symbology representing a card associated with each of the unmanned teamed assets. By the touchscreen display, an operator selects one of the unmanned teamed assets, for emphasis of the flight path. The flight paths of the non-selected unmanned teamed assets remain displayed when the selected flight path is emphasized. The operator may select the unmanned teamed asset by the flight path or by the unmanned teamed asset card. |
| FILED | Tuesday, April 13, 2021 |
| APPL NO | 17/229585 |
| CURRENT CPC | Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 43/00 (20130101) Electric Digital Data Processing G06F 3/0482 (20130101) G06F 3/0484 (20130101) Original (OR) Class G06F 3/0488 (20130101) Traffic Control Systems G08G 5/0069 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220328256 | Cordova |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ADA Technologies, Inc. (Littleton, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen Cordova (Colorado Springs, Colorado) |
| ABSTRACT | An electrolyte is introduced into an electrochemical device, passed, via a first corrugation feature, through a first electrode of the electrochemical device, passed through an ion permeable separator, and contacted with a second electrode. The first or second electrode comprises a second corrugation feature in fluid communication with the first corrugation feature to contact the electrolyte across a portion of an active surface of the first or second electrode. |
| FILED | Monday, April 25, 2022 |
| APPL NO | 17/728031 |
| CURRENT CPC | Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/10 (20130101) Original (OR) Class H01G 11/12 (20130101) H01G 11/26 (20130101) H01G 11/50 (20130101) H01G 11/52 (20130101) H01G 11/58 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/13 (20130101) H01M 10/05 (20130101) H01M 50/60 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220328311 | Kim et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Jeehwan Kim (Cambridge, Massachusetts); Yunjo Kim (Cambridge, Massachusetts); Sanghoon Bae (Cambridge, Massachusetts) |
| ABSTRACT | Epitaxial growth of materials, and related systems and articles, are generally described. |
| FILED | Thursday, September 03, 2020 |
| APPL NO | 17/639951 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/26 (20130101) C23C 16/56 (20130101) Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 23/04 (20130101) C30B 25/04 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/02392 (20130101) H01L 21/02444 (20130101) H01L 21/02461 (20130101) H01L 21/02463 (20130101) H01L 21/02505 (20130101) H01L 21/02543 (20130101) Original (OR) Class H01L 21/02642 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220328322 | Boris et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | David R. Boris (Silver Spring, Maryland); Scott G. Walton (Fairfax, Virginia) |
| ABSTRACT | Methods and apparatuses for the production of HF in an electron-beam generated plasma. A gas containing fluorine, hydrogen, and an inert gas such as argon, e.g., Ar/SF6/H2O or Ar/SF6/NH3 flows into a plasma treatment chamber to produce a low pressure gas in the chamber. An electron beam directed into the gas forms a plasma from the gas, with energy from the electron beam dissociating the F-containing molecules, which react with H-containing gas to produce HF in the plasma. Although the concentration of the gas phase HF in the plasma is a very small fraction of the total gas in the chamber, due to its highly reactive nature, the low concentration of HF produced by the method of the present invention is enough to modify the surfaces of materials, performing the same function as aqueous HF solutions to remove oxygen from an exposed material. |
| FILED | Tuesday, June 28, 2022 |
| APPL NO | 17/851203 |
| CURRENT CPC | Cleaning in General; Prevention of Fouling in General B08B 7/00 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 37/321 (20130101) H01J 37/3233 (20130101) H01J 37/3244 (20130101) H01J 2237/335 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/02049 (20130101) H01L 21/31116 (20130101) Original (OR) Class H01L 21/67069 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220328757 | Pereira de Sousa et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Duarte José Pereira de Sousa (Saint Paul, Minnesota); Cesar Octavio Ascencio (Falcon Heights, Minnesota); Jian-Ping Wang (Shoreview, Minnesota); Tony Low (Woodbury, Minnesota) |
| ABSTRACT | In some examples, a device includes a magnetic tunnel junction including a first Weyl semimetal layer, a second Weyl semimetal layer, and a dielectric layer positioned between the first and second Weyl semimetal layers. The magnetic tunnel junction may have a large tunnel magnetoresistance ratio, which may be greater than five hundred percent or even greater than one thousand percent. |
| FILED | Thursday, April 08, 2021 |
| APPL NO | 17/225785 |
| CURRENT CPC | Static Stores G11C 11/18 (20130101) G11C 11/161 (20130101) G11C 11/1675 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/222 (20130101) H01L 43/04 (20130101) Original (OR) Class H01L 43/06 (20130101) H01L 43/10 (20130101) H01L 43/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220328824 | Durstock et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States as represented by the Secretary of the Air Force (Wright Patterson AFB, Ohio) |
| ASSIGNEE(S) | Government of the United States as represented by the Secretary of the Air Force (Wright Patterson AFB, Ohio) |
| INVENTOR(S) | Michael F. Durstock (West Chester, Ohio); Ryan R. Kohlmeyer (Dayton, Ohio); Aaron J. Blake (Huber Heights, Ohio) |
| ABSTRACT | A method forming a composite electrolyte by preparing a suspension. The suspension includes a solvent (comprising 90 wt % to 95 wt % of a total weight of liquids); a non-solvent (comprising 5 wt % to 50 wt % of a total weight of liquids); a binder (comprising 20 wt % to 50 wt % of a total weight of the composite electrolyte) and selected from the group consisting of PVDF, PVDF-HFP, PFTE, PEO, PMMA, PAN, CNC, SBR, and combinations thereof; and a ceramic filler (comprising 50 wt % to 80 wt % of the total weight of the composite electrolyte) having a cross-section diameter ranging from 50 nm to 150 nm and being selected from the group consisting of Al2O3, SiO2, TiO2, MgO, Li2O, LiAlO2, BaTiO3, LaGP, LATP, LLTO, and combinations thereof. The suspension is cast or printed and dried. |
| FILED | Wednesday, April 20, 2022 |
| APPL NO | 17/725101 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/66 (20130101) H01M 4/0409 (20130101) H01M 4/485 (20130101) H01M 4/525 (20130101) Original (OR) Class H01M 4/622 (20130101) H01M 4/623 (20130101) H01M 4/624 (20130101) H01M 4/625 (20130101) H01M 4/5825 (20130101) H01M 10/056 (20130101) H01M 10/0568 (20130101) H01M 10/0569 (20130101) H01M 50/116 (20210101) H01M 50/446 (20210101) H01M 2004/027 (20130101) H01M 2220/30 (20130101) H01M 2300/0037 (20130101) H01M 2300/0065 (20130101) H01M 2300/0091 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220329063 | Zhang |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Di Zhang (Carmel, California) |
| ABSTRACT | A solid state circuit breaker that may include a metal oxide varistor (MOV) that is connected in series to a thyristor, the MOV to clamp voltage of current flowing through the solid state circuit breaker; the thyristor including a gate to control flow of the current to the MOV along a first path to the MOV; a breakover diode to activate at a target voltage level to allow the current to flow to the MOV along a second path; and a Zener diode to close the gate and allow current to flow along the first path in response to the current on the second path. |
| FILED | Tuesday, March 01, 2022 |
| APPL NO | 17/684335 |
| CURRENT CPC | Resistors H01C 7/12 (20130101) H01C 7/108 (20130101) Electric Switches; Relays; Selectors; Emergency Protective Devices H01H 2009/543 (20130101) Emergency Protective Circuit Arrangements H02H 9/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220329417 | Farinholt et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jacob M. Farinholt (Bowie, Maryland); James E. Troupe (Austin, Texas) |
| ASSIGNEE(S) | United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Jacob M. Farinholt (Bowie, Maryland); James E. Troupe (Austin, Texas) |
| ABSTRACT | A quantum key distribution (QKD) receiver is provided for communicating with a transmitter that produces a plurality of entangled photon qubit pairs to send one qubit from each pair randomly alternating between basis states. The receiver includes a first polarized beam splitter, an orthogonal pair of photon detectors, a weak measurement apparatus, a broadcaster, an error rate estimator, and a post-processor. The first splitter receives the one qubit for passage or reflection. The photon detector pair measures the one qubit from passage or reflection. The apparatus performs a weak measurement on the one qubit and includes an impedance device to induce time delay, a pair of mirrors flanking the impedance device, and second and third polarized beam splitters for alternatively passing the one qubit to each other and to the pair of mirrors. The broadcaster for sending weak measurement results from the detectors to the transmitter. The error rate estimator determines whether the weak measurement satisfies a bit error threshold. The post-processor corrects the weak measurement from one of the basis states in response to a shared random key from the transmitter. |
| FILED | Thursday, April 09, 2020 |
| APPL NO | 16/844404 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0858 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220329736 | Schlaerth |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John B. Schlaerth (Redondo Beach, California) |
| ABSTRACT | A system and method of operating a focal plane array of a camera assembly for a space vehicle in orbit includes scanning across a scene containing a target surface using the focal plane array, generating a plurality of sampled signals for the scene using a plurality of detectors of the focal plane array, co-adding the sampled signals to produce an output having a constant spatial resolution, and correcting a temporal shift in a line-of-sight of the focal plane array by rotating the space vehicle or the camera assembly to null relative motion at a center point of a scan. |
| FILED | Monday, April 12, 2021 |
| APPL NO | 17/227997 |
| CURRENT CPC | Pictorial Communication, e.g Television H04N 5/23212 (20130101) H04N 5/23299 (20180801) Original (OR) Class H04N 2005/2255 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20220322668 | Ghiladi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Reza Arman Ghiladi (Raleigh, North Carolina); Richard John Spontak (Raleigh, North Carolina); Frank Scholle (Raleigh, North Carolina) |
| ABSTRACT | In one aspect, the disclosure relates to antimicrobial compositions containing a photosensitizer, a crosslinkable polymer, and a solvent; methods of applying the same to surfaces; methods of using the same to impart antimicrobial properties to surfaces; and surfaces treated using the same. In one aspect, the compositions are effective against a wide range of viruses and bacteria, stable in ambient room lighting, and effective for a period of up to four weeks or longer after a single application. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure. |
| FILED | Monday, April 11, 2022 |
| APPL NO | 17/658663 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 25/10 (20130101) A01N 43/84 (20130101) A01N 43/90 (20130101) Original (OR) Class Biocidal, Pest Repellant, Pest Attractant or Plant Growth Regulatory Activity of Chemical Compounds or Preparations A01P 1/00 (20210801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220322916 | Bagwell et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Actuated Medical, Inc. (Bellefonte, Pennsylvania) |
| ASSIGNEE(S) | Actuated Medical, Inc. (Bellefonte, Pennsylvania) |
| INVENTOR(S) | Roger B. Bagwell (Bellefonte, Pennsylvania); Eric J. Hopkins (Bellefonte, Pennsylvania); Casey A. Scruggs (Bellefonte, Pennsylvania); Kevin A. Snook (State College, Pennsylvania) |
| ABSTRACT | A medical instrument having integrated arms extending from a proximal end to a distal end, and a handpiece with actuators to control movement of the arms. The instrument includes an insertion tube having arm channel(s) for receiving an arm therethrough. Each arm includes an engagement member at the distal end of resilient material with a natural non-linear configuration when deployed but deforming when retracted into the arm channel when retracted. Arm channels may be located at different radial distances from one another in the insertion tube so the engagement members may be at radial angles relative to one another when deployed. Arms and engagement members are movable between at least a first position and second position relative to one another by rotation and/or translational motion of the corresponding actuator, to contact tissue or deflect a tool extended through the working channel of the endoscope. |
| FILED | Tuesday, June 14, 2022 |
| APPL NO | 17/839989 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/0014 (20130101) A61B 1/00087 (20130101) Original (OR) Class A61B 1/00094 (20130101) A61B 17/29 (20130101) A61B 2017/00818 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220322999 | Clifford et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Emory University (Atlanta, Georgia); Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gari Clifford (Decatur, Georgia); Ayse Cakmak (Atlanta, Georgia); Christopher Rozell (Decatur, Georgia); Adam Willats (Atlanta, Georgia) |
| ABSTRACT | The present disclosure relates to systems and methods for detecting sleep-wake activity of a subject using change-point events determined from physiological and/or movement measures. In one implementation, the method may include obtaining at least one set of sensor data generated by one or more sensors for a period of time. The method may also include generating at least two measures from the at least one set of sensor data. The method may further include determining a series of change point events for each measure for the period of time. The method may include determining a sleep stage for each interval of the period of time from at least two sleep stages by processing the series of change point events for each measure using a sleep stage classifier. The sleep stage classifier may include a set of parameters for each measure. |
| FILED | Friday, September 04, 2020 |
| APPL NO | 17/640405 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0205 (20130101) A61B 5/1118 (20130101) A61B 5/02416 (20130101) A61B 5/4809 (20130101) Original (OR) Class A61B 5/4812 (20130101) A61B 5/7275 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 40/67 (20180101) G16H 50/70 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220323911 | DIALLO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (PASADENA, California); KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY (DAEJEON, South Korea) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mamadou S. DIALLO (PASADENA, California); Madhusudhana Rao KOTTE (DAEJEON, South Korea); Alex KUVAREGA (DAEJEON, South Korea) |
| ABSTRACT | Described herein are mixed matrix filtration membranes and related, dendrimers, dendrimer particles, compositions, methods and systems and in particular mixed matrix filtration membranes with an embedded dendrimer particles and related compositions, methods, and systems wherein each dendrimer particle comprises at least two dendrimers each having at least two core chemical moieties having a core multiplicity Nc; branch cell units attached to the core chemical moiety or one to another, with the branch cell units attached one to another having a branch cells multiplicity Nb; and a number of surface functional groups Z presented on terminal branch cell units, wherein NcNbG with G≤3. |
| FILED | Thursday, November 11, 2021 |
| APPL NO | 17/524572 |
| CURRENT CPC | Separation B01D 61/025 (20130101) B01D 61/145 (20130101) B01D 67/0006 (20130101) B01D 67/0009 (20130101) B01D 67/0011 (20130101) B01D 69/12 (20130101) B01D 69/125 (20130101) B01D 69/141 (20130101) Original (OR) Class B01D 71/60 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/285 (20130101) C02F 1/444 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220323913 | Jeong et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hae-Kwon Jeong (College Station, Texas); Yinying Hua (College Station, Texas); Sung-Hwan Park (College Station, Texas) |
| ASSIGNEE(S) | Texas A and M University (College Station, Texas) |
| INVENTOR(S) | Hae-Kwon Jeong (College Station, Texas); Yinying Hua (College Station, Texas); Sung-Hwan Park (College Station, Texas) |
| ABSTRACT | Provided herein are one-step methods for fabricating an asymmetric mixed-matrix membrane and the asymmetric mixed matrix membrane so fabricated. In the one step method an asymmetric polymer film is formed from a liquid polymer solution and a ligand precursor simultaneously with the formation of metal-organic framework filler particles therein. Also provided is a method for separating a mixture of gases or of liquids by flowing the mixture through the asymmetric mixed matrix membrane. |
| FILED | Tuesday, April 12, 2022 |
| APPL NO | 17/719143 |
| CURRENT CPC | Separation B01D 67/0079 (20130101) B01D 69/125 (20130101) B01D 69/148 (20130101) Original (OR) Class B01D 71/028 (20130101) B01D 71/64 (20130101) B01D 2323/21 (20130101) B01D 2325/022 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220323914 | Mitra et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | New Jersey Institute of Technology (Newark, New Jersey) |
| ASSIGNEE(S) | New Jersey Institute of Technology (Newark, New Jersey) |
| INVENTOR(S) | Somenath Mitra (Bridgewater, New Jersey); Sagar Roy (Newark, New Jersey); Sumona Paul (Harrison, New Jersey) |
| ABSTRACT | A nanocarbon immobilized membrane (NCIM) is disclosed. The nanocarbon immobilized membrane is sized to purify different organic-water mixtures. The nanocarbon immobilized membrane can be used to purify solvents, fuels, and other organic compounds. Data using heptane-water, octane-water, fuel-water, and paint thinner-water show 99.9% separation efficiency. High organic flux is also seen at relatively low pressure. This approach has numerous applications, including fuel purification, oil spills clean-up, separation of commercial emulsions, and solvent purification. |
| FILED | Friday, March 25, 2022 |
| APPL NO | 17/704613 |
| CURRENT CPC | Separation B01D 17/02 (20130101) B01D 17/085 (20130101) B01D 67/0093 (20130101) B01D 69/02 (20130101) B01D 71/021 (20130101) Original (OR) Class B01D 71/34 (20130101) B01D 71/36 (20130101) B01D 71/70 (20130101) B01D 2325/38 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/44 (20130101) C02F 2101/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220323928 | Andriolo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jessica M. Andriolo (Butte, Montana); M. Katie Hailer (Butte, Montana); Jack L. Skinner (Butte, Montana); Jerome P. Downey (Butte, Montana); David L. Hutchins (Butte, Montana); Teagan Leitzke (Butte, Montana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jessica M. Andriolo (Butte, Montana); M. Katie Hailer (Butte, Montana); Jack L. Skinner (Butte, Montana); Jerome P. Downey (Butte, Montana); David L. Hutchins (Butte, Montana); Teagan Leitzke (Butte, Montana) |
| ABSTRACT | Fresh water contamination by heavy metals results from a variety of sources and can be damaging to wildlife, alter landscapes, and impact human health. metals removal form water sources is desirable for improving water quality and preventing adverse effects, but also for metals collection and recycling. Adsorption is a desirable metals extraction technique due to economic feasibility. Nanoscale materials exhibit high surface-area-to-volume ratio that lends to high adsorption and reactivity, making them ideal candidates for adsorptive metals extraction processes. Despite these properties, nanomaterials have elicited safety concerns. The extraordinarily small dimensions of these materials allow them to maneuver biological systems, tissues, and even cells, and combined with high reactivity, this translocation can result in toxic effects. It is therefore imperative that safety of nanomaterials for metals extraction be evaluated in addition to adsorptive properties. The current invention describes nanoparticles composed of magnetite, coated in hydroxyapatite, and functionalized for adsorption with titanium dioxide (TiHAMNPs). This material is safe, provides significant adsorption of metals, and allows efficient collection in magnetic systems. |
| FILED | Friday, April 08, 2022 |
| APPL NO | 17/716739 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/048 (20130101) Original (OR) Class B01J 20/3085 (20130101) B01J 20/3295 (20130101) B01J 20/28016 (20130101) B01J 2220/42 (20130101) Reclamation of Contaminated Soil B09C 1/08 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/48 (20130101) C02F 1/281 (20130101) C02F 1/288 (20130101) C02F 2101/20 (20130101) C02F 2305/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220323960 | Baday et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Murat Baday (Menlo Park, California); Naside Gozde Durmus (Palo Alto, California); Semih Calamak (Palo Alto, California); Utkan Demirci (Stanford, California); Ronald W. Davis (Palo Alto, California); Lars Steinmetz (San Francisco, California); Jaeyoung Yang (Palo Alto, California); Thiruppathiraja Chinnasamy (Mountain View, California); Alessandro Tocchio (San Francisco, California) |
| ABSTRACT | A heterogeneous population of cells are separated and collected according to a method. The heterogeneous population of cells in a paramagnetic medium are placed in a fluidic channel in which the fluidic channel comprises two or more outlets. The heterogeneous population of cells in the fluidic channel are separated based on differences in magnetic susceptibility and density of the heterogeneous population of cells. Fluid comprising the separated cells is withdrawn from the two or more outlets using variable flow rates by fluidic pumps at respective ones of the two or more outlets simultaneously to fractionalize the fluid comprising the separated cells across the two or more outlets by manipulation of the variable flow rates relative to one another. |
| FILED | Wednesday, April 20, 2022 |
| APPL NO | 17/724729 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) Original (OR) Class B01L 3/502784 (20130101) B01L 2200/0652 (20130101) B01L 2300/0864 (20130101) B01L 2400/043 (20130101) Magnetic or Electrostatic Separation of Solid Materials From Solid Materials or Fluids; Separation by High-voltage Electric Fields B03C 1/32 (20130101) B03C 1/288 (20130101) B03C 2201/18 (20130101) B03C 2201/26 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/14 (20130101) G01N 33/574 (20130101) G01N 33/4875 (20130101) G01N 33/54366 (20130101) G01N 33/56966 (20130101) G01N 2015/1486 (20130101) Image Data Processing or Generation, in General G06T 7/0016 (20130101) G06T 2207/30101 (20130101) G06T 2207/30242 (20130101) G06T 2211/428 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220324707 | ZHOU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Wyoming (Laramie, Wyoming) |
| ASSIGNEE(S) | University of Wyoming (Laramie, Wyoming) |
| INVENTOR(S) | Jing ZHOU (Laramie, Wyoming); Joseph HOLLES (Laramie, Wyoming); Richard HORNER (Laramie, Wyoming); Jintao MIAO (Laramie, Wyoming); Daniel BRAEDT (Laramie, Wyoming) |
| ABSTRACT | Provided herein are catalyst materials and processes for processing hydrocarbons. For example, doped ceria-supported metal catalysts are provided exhibiting good activity and stability for commercially relevant dry reforming of methane as well as mixed hydrocarbon feedstocks under process conditions including low temperature and long term operation. Useful doped ceria-supported metal catalysts include nickel dispersed over Ti-doped ceria. |
| FILED | Friday, April 01, 2022 |
| APPL NO | 17/711365 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/002 (20130101) B01J 23/10 (20130101) B01J 23/83 (20130101) B01J 23/755 (20130101) B01J 35/023 (20130101) Non-metallic Elements; Compounds Thereof; C01B 3/38 (20130101) Original (OR) Class C01B 2203/0238 (20130101) C01B 2203/1614 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220324779 | Ebikade et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Elvis O. Ebikade (Washington, District of Columbia); Eric R. Gottlieb (Newark, Delaware); Robert M. O'Dea (Newark, Delaware); Thomas H. Epps, III (Bear, Delaware); Dionisios Vlachos (Newark, Delaware) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elvis O. Ebikade (Washington, District of Columbia); Eric R. Gottlieb (Newark, Delaware); Robert M. O'Dea (Newark, Delaware); Thomas H. Epps, III (Bear, Delaware); Dionisios Vlachos (Newark, Delaware) |
| ABSTRACT | Disclosed herein are systems and methods of depolymerizing a lignin component of a lignin-containing material. The method comprising contacting the lignin-containing material with a solvent and optionally a catalyst at a temperature in the range of 180-300° C. and at a maximum operating pressure of less than 10 barG during the depolymerization of the lignin component of the material and collecting at least one volatile stream comprising one or more depolymerized lignin products. In an embodiment, the step of contacting is carried out in a reactive distillation reactor, and the step of collecting comprises concurrently collecting at least one volatile stream via distillation apparatus connected to the reactive distillation reactor, at least one of the one or more depolymerized lignin products comprises a substituted phenol having the following general formula: (I) wherein R1 is H, methyl, ethyl, n-propyl, propenyl, or allyl, and R2 and R3 are independently selected from H or methoxy group. |
| FILED | Friday, August 14, 2020 |
| APPL NO | 17/634271 |
| CURRENT CPC | Separation B01D 3/009 (20130101) B01D 36/00 (20130101) Acyclic or Carbocyclic Compounds C07C 37/004 (20130101) Original (OR) Class C07C 41/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220325136 | Wynne et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VIRGINIA COMMONWEALTH UNIVERSITY (Richmond, Virginia) |
| ASSIGNEE(S) | VIRGINIA COMMONWEALTH UNIVERSITY (Richmond, Virginia) |
| INVENTOR(S) | Kenneth J. Wynne (Midlothian, Virginia); Chenyu Wang (Midlothian, Virginia) |
| ABSTRACT | A composition and uses thereof are provided, comprising a polymerization product of a reactant composition, the reactant composition comprising: (a) vinyldimethylsiloxy-terminated polydimethylsiloxane, as monomer (MVIDMVI); (b) 45-55% poly(methylhydro-co-dimethylsiloxane), α, Ω-trimethylsiloxy terminated, as crosslinker (MVIDMVI); (c) platinum-divinyltetram-CA ethyl-disiloxane complex, as catalyst; (d) 2,4,6,8-tetramethyl-2,4,6,8-tetravinylcyclotetrasiloxane, as inhibitor; and (e) a filler-like resin composition comprising one or more of dimethylvinylated silica, trimethylated silica, and tetra(trimethylsiloxy) silane, as active ingredient, and one or more of xylene, ethylbenzene and toluene (MQ-R resin). |
| FILED | Friday, August 28, 2020 |
| APPL NO | 17/639291 |
| CURRENT CPC | Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/013 (20180101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 7/62 (20180101) C09D 183/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220325235 | YOON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Seongkyu YOON (Lowell, Massachusetts); Bingyu KUANG (Worcester, Massachusetts); Shaun GALBRAITH (Lowell, Massachusetts) |
| ABSTRACT | A method of cell culture includes (i) culturing cells in a cell culture medium, and (ii) maintaining at least one metabolite selected from aconitic acid (AA), leucinic acid (HICA), cytidine monophosphate (CMP), methylsuccinic acid (MSA), trigonelline (TRI) and N-acetylputrescinium (NAP) below an inhibitory concentration in the cell culture medium for the at least one metabolite. |
| FILED | Friday, August 14, 2020 |
| APPL NO | 17/635144 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0018 (20130101) Original (OR) Class C12N 2500/32 (20130101) Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/44 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/7206 (20130101) G01N 2030/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220325267 | Wijesinghe |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wijesinghe Mudiyanselage Hiran Shanaka Wijesinghe (Old Bridge, New Jersey) |
| ABSTRACT | Flagellated magnetotactic bacteria (MTB), specifically AMB-1 bacteria, are provided as a system of microrobots, and the heterogeneity of their hydrodynamic interactions with a solid-liquid boundary wall is systematically exploited to control multiple microrobots using a global magnetic field. A method comprises providing a plurality of a microrobots and controlling the microrobots using a global magnetic field. |
| FILED | Tuesday, February 08, 2022 |
| APPL NO | 17/667058 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 13/00 (20130101) Original (OR) Class Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 1/42 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220325432 | Jariwala et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Deep Jariwala (Philadelphia, Pennsylvania); Eric Andrew Stach (Swarthmore, Pennsylvania); Pawan Kumar (Philadelphia, Pennsylvania) |
| ABSTRACT | Provided are novel transition metal dichalcogenides having a platelet structure and comprising a 2H phase region and/or a 3R phase region. The platelets exhibit a narrow size distribution and comparatively high surface area and edge area, which characteristics render the platelets especially suitable for catalysis applications, as well as use in electronic devices. Also provided are methods of synthesizing the disclosed transition metal dichalcogenide platelets. |
| FILED | Friday, February 18, 2022 |
| APPL NO | 17/674964 |
| CURRENT CPC | Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 39/00 (20130101) Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 1/023 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220325439 | PHELAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William A. PHELAN (Baltimore, Maryland); Tanya BERRY (Baltimore, Maryland); Mekhola SINHA (Baltimore, Maryland); Tyrel Matthew MCQUEEN (Baltimore, Maryland) |
| ABSTRACT | Metal oxides and method for forming the method oxides are provided. The disclosed functional metal oxides are single crystalline or polycrystalline metal oxides, such as, for example, SrVO3, and have dimensions, phase purity, and crystalline quality previously unachievable. The disclosed methods include a combination of a gas atmosphere, vacuum sintering, and laser-based directional solidification of a seed rod in contact with a feed rod that is scalable for production quantities. |
| FILED | Friday, September 04, 2020 |
| APPL NO | 17/639805 |
| CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 13/16 (20130101) C30B 29/30 (20130101) Original (OR) Class Electric Discharge Tubes or Discharge Lamps H01J 1/144 (20130101) H01J 2201/2817 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220326171 | SCHUMANN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Todd R. SCHUMANN (Longmont, Colorado); Yong-Kyu YOON (Gainesville, Florida); Renuka BOWROTHU (Gainesville, Florida); Kyoung Tae KIM (Woodinville, Washington) |
| ABSTRACT | Various examples are provided related to electrochemical phosphate/pH (P/pH) sensors, systems and related methods. In one example, a P/pH sensor includes a substrate and collocated phosphate (P) electrode and pH electrode formed on a surface of the substrate. The P electrode includes a cobalt (Co) sensing window disposed on a first copper (Cu) sensor pad; and the pH electrode includes an antimony (Sb) sensing window disposed on a second Cu sensor pad. The P/pH sensor can include a reference electrode, and may also include other sensor electrodes such as, e.g., a nitrate electrode. |
| FILED | Friday, September 11, 2020 |
| APPL NO | 17/642555 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/302 (20130101) Original (OR) Class G01N 27/4035 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220326175 | Azoulay et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Jason Azoulay (Hattiesburg, Mississippi); Joshua Tropp (Hattiesburg, Mississippi); Vikash Kaphle (Hattiesburg, Mississippi); Anthony Benasco (Hattiesburg, Mississippi); Amar Flood (Bloomington, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason Azoulay (Hattiesburg, Mississippi); Joshua Tropp (Hattiesburg, Mississippi); Vikash Kaphle (Hattiesburg, Mississippi); Anthony Benasco (Hattiesburg, Mississippi); Amar Flood (Bloomington, Indiana) |
| ABSTRACT | A semiconductor sensor device for detecting an analyte including a semiconducting layer, one or more organic molecules in the semiconducting layer, and one or more receptor molecules, comprising a poly-cyanostilbene macrocycle, wherein the one or more receptors is embedded within or onto the semiconducting layer of the semiconductor sensor device. Also disclosed is a method of preparing the semiconductor sensor device including a step of coupling the one or more receptor molecules into or onto the semiconducting layer of the semiconductor sensor device, a dielectric surface, or an electrode surface. Also described is chemical sensing device including the semiconductor sensor device and other elements of a sensing device. |
| FILED | Thursday, November 04, 2021 |
| APPL NO | 17/519083 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/414 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/05 (20130101) H01L 51/0036 (20130101) H01L 51/0043 (20130101) H01L 51/0056 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220326188 | Ozevin |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board Of Trustees Of The University Of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Didem Ozevin (Chicago, Illinois) |
| ABSTRACT | A MEMS AE transducer system is provided that takes advantage of the low power consumption and lightweight characteristics of MEMS AE transducers, while also achieving higher sensing sensitivity. To address the problem of low sensitivity typically associated with MEMS AE transducers, electrical responses of multiple MEMS AE transducers operating at different frequency ranges are combined to increase the bandwidth and sensitivity of the MEMS AE transducer system. As the frequencies are constructive, the combined response on a single channel is the actual summation of two signals with an improved signal to noise ratio. Additionally, each frequency can be decomposed because they are well separated from each other due to the super narrowband response and high Quality factor of MEMS AE transducers. |
| FILED | Thursday, July 23, 2020 |
| APPL NO | 17/628999 |
| CURRENT CPC | Microstructural Devices or Systems, e.g Micromechanical Devices B81B 3/0021 (20130101) B81B 7/0032 (20130101) B81B 2201/0271 (20130101) B81B 2203/04 (20130101) B81B 2203/0118 (20130101) B81B 2203/0127 (20130101) B81B 2207/01 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/14 (20130101) Original (OR) Class Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 1/24 (20130101) H04R 2201/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220326233 | DUTTA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Wyoming (Laramie, Wyoming) |
| ASSIGNEE(S) | University of Wyoming (Laramie, Wyoming) |
| INVENTOR(S) | Debashis DUTTA (Laramie, Wyoming); Michael TAYLOR (Laramie, Wyoming); Ravichander Rao PEESARA (Laramie, Wyoming) |
| ABSTRACT | In one embodiment, the present invention includes a system for detecting a target analyte which includes a microfluidic device having least one microfluidic channel with a binding surface positioned in the microfluidic channel with further include a first electrode and a second electrode. The system may further include a detector and a voltage supply. Also included is a method to detect a target analyte using a described microfluidics device, introducing solution with a target analyte to a binding surface, and binding the target analyte to the binding surface by applying an electrical potential between the first and second electrodes during at least a portion of the binding step, which enhances the rate of binding of the target analyte molecules to the binding molecules. The method then includes the steps of detecting a reporter molecule which corresponds to the amount of the bound target analyte molecules, which correlates with the amount of target analyte in the original sample. The method may also include multiple applications of sample to the binding surface prior to the detection step. |
| FILED | Monday, April 18, 2022 |
| APPL NO | 17/722945 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502776 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/76 (20130101) G01N 33/54306 (20130101) G01N 33/54366 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220326502 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Jonathan T.C. Liu (Seattle, Washington); Lindsey A. Barner (Seattle, Washington); Adam K. Glaser (Seattle, Washington) |
| ABSTRACT | Apparatuses, systems, and methods for solid immersion meniscus lenses (STMlenses). An optical system may include a sample holder with a first side which supports a sample, and a second side opposite the first side. The second side of the sample holder may be in contact with an immersion fluid. Light passing between the sample and an objective lens may pass through the sample holder, immersion fluid, and a SIMlens positioned between the immersion fluid and objective. The SIMlens may have a first curved surface and a second curved surface, each of which may be shaped to match a wavefront of the light as it passes through the SIMlens. The immersion fluid, SIMlens, and environment containing the objective may all have different refractive indices. |
| FILED | Thursday, February 24, 2022 |
| APPL NO | 17/680033 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 21/26 (20130101) G02B 21/0032 (20130101) G02B 21/33 (20130101) Original (OR) Class G02B 21/248 (20130101) G02B 21/367 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220326610 | Kim et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mingu Kim (Atlanta, Georgia); Oliver Brand (Atlanta, Georgia); Devin K. Brown (Atlanta, Georgia) |
| ABSTRACT | In a method making a flexible electrical conductor, a mask layer (216) is applied to a substrate (210). A portion of the mask layer (216) is removed to expose the substrate (210) in an exposed shape (220) corresponding to the conductor. A liquid phase conductor (232) is applied to the portion of the substrate (210). The mask layer (216) is dissolved with a solvent (238) to leave a shaped liquid phase conductor (234) corresponding to the exposed shape on the substrate (210). A primary elastomer layer (240) is applied onto the substrate (210) and the shaped liquid phase conductor (234). The primary elastomer layer (240) and the shaped liquid phase conductor (234) are removed from the substrate (210). A secondary elastomer layer (242) is applied to the shaped liquid phase conductor (234) and the primary elastomer layer (240) to seal the shaped liquid phase conductor (234) therein. |
| FILED | Tuesday, June 21, 2022 |
| APPL NO | 17/845393 |
| CURRENT CPC | Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/0002 (20130101) Original (OR) Class Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/16 (20130101) H01B 1/22 (20130101) H01B 7/0027 (20130101) H01B 13/0026 (20130101) H01B 13/322 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220326803 | Do et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian H. Do (Plant City, Florida); Allison M. Okamura (Mountain View, California); Laura H. Blumenschein (Lafayette, Indiana) |
| ABSTRACT | A macro-mini actuation mechanism for pneumatic pouches is provided which involves stacking smaller proximal pouches (proximal layer) underneath larger distal pouches (distal layer). The proximal layer of smaller pouches is the contact area with e.g. a (human) body. Macro-mini pneumatic actuation of pouches for wearable haptic displays allows for the control of contact area of pneumatic pouches and the ability to cover large areas while maintaining a fast-dynamic response and higher spatial resolutions. This stacked pouch concept allows for pressure/force feedback to a user—something which cannot be rendered by vibrotactile actuators alone. Control of effective pouch height may also allow a potential wearable haptic display to better conform to the human body. A pressure-based display with stacked pouches could allow for larger tolerances between the display and the human body without sacrificing contact area, allowing better fit across users. |
| FILED | Monday, April 11, 2022 |
| APPL NO | 17/718043 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/016 (20130101) G06F 3/0416 (20130101) Original (OR) Class Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 6/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220326958 | Ganguly et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Amlan Ganguly (W. Henrietta, New York); Sai Manoj Pudukotai Dinakarrao (Falls Church, Virginia); Mark Connolly (Newfane, New York); Purab Ranjan Sutradhar (Rochester, New York); Sathwika Bavikadi (Fairfax, Virginia); Mark Allen Indovina (Rochester, New York) |
| ASSIGNEE(S) | Rochester Institute of Technology (Rochester, New York) |
| INVENTOR(S) | Amlan Ganguly (W. Henrietta, New York); Sai Manoj Pudukotai Dinakarrao (Falls Church, Virginia); Mark Connolly (Newfane, New York); Purab Ranjan Sutradhar (Rochester, New York); Sathwika Bavikadi (Fairfax, Virginia); Mark Allen Indovina (Rochester, New York) |
| ABSTRACT | A processing element includes a PIM cluster configured to read data from and write data to an adjacent DRAM subarray, wherein the PIM cluster has a plurality of processing cores, each processing core of the plurality of processing cores containing a look-up table, and a router connected to each processing core, wherein the router is configured to communicate data among each processing core; and a controller unit configured to communicate with the router, wherein the controller unit contains an executable program of operational decomposition algorithms. The look-up tables can be programmable. A DRAM chip including a plurality of DRAM banks, each DRAM bank having a plurality of interleaved DRAM subarrays and a plurality of the PIM clusters configured to read data from and write data to an adjacent DRAM subarray is disclosed. |
| FILED | Monday, April 11, 2022 |
| APPL NO | 17/717947 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/3001 (20130101) G06F 9/3887 (20130101) Original (OR) Class G06F 9/5072 (20130101) G06F 12/0851 (20130101) Computer Systems Based on Specific Computational Models G06N 3/063 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220327238 | Bi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xuan Bi (Minneapolis, Minnesota); Xiaotong Shen (Minneapolis, None) |
| ABSTRACT | A method includes storing a value in data storage so that a third party is prevented from accessing the value, retrieving the value and applying a first transform to the value to form a transformed value having a uniform distribution. Noise is added to the transformed value to form a sum and a second transform is applied to the sum to form a transformed sum having a uniform distribution. An inverse of the first transform is applied to the transformed sum to form a privatized value and the privatized value is provided to the third party. |
| FILED | Thursday, March 31, 2022 |
| APPL NO | 17/710145 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/6254 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220327826 | Chaterji et al. |
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| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Somali Chaterji (West Lafayette, Indiana); Saurabh Bagchi (West Lafayette, Indiana); Ran Xu (West Lafayette, Indiana) |
| ABSTRACT | System and methods for content- and contention-aware object detection are provided. A system may receive video information and perform object detection and object tracking based on an execution configuration. The system may approximate an optimized execution configuration. To approximate the optimized execution configuration, the system may identify, based on the video information, a plurality of content features. The system may further measure a contention level of a computer resource or multiple resources. The system may approximate, based on the content features and the utilization metric, latency metrics, for a plurality of execution configuration sets, respectively. The system may also approximate, based on the content features, accuracy metrics for the execution configuration sets, respectively. The system may select the optimized execution configuration set in response to satisfaction of a performance criterion. The system may perform object detection and object tracking based on the optimized execution configuration set. |
| FILED | Thursday, March 31, 2022 |
| APPL NO | 17/710233 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 3/40 (20130101) G06T 7/50 (20170101) G06T 7/248 (20170101) G06T 2207/10016 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) Image or Video Recognition or Understanding G06V 10/82 (20220101) G06V 10/764 (20220101) G06V 10/7747 (20220101) G06V 20/41 (20220101) Original (OR) Class G06V 20/46 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220327954 | MARGOLIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Gayla MARGOLIN (Los Angeles, California); Adela C. AHLE (San Francisco, California); Matthew William AHLE (San Francisco, California); Theodora CHASPARI (College Station, California); Shrikanth Sambasivan NARAYANAN (Santa Monica, California) |
| ASSIGNEE(S) | University of Southern California (Los Angeles, California) |
| INVENTOR(S) | Gayla MARGOLIN (Los Angeles, California); Adela C. AHLE (San Francisco, California); Matthew William AHLE (San Francisco, California); Theodora CHASPARI (College Station, California); Shrikanth Sambasivan NARAYANAN (Santa Monica, California) |
| ABSTRACT | A method for promoting interpersonal interactions includes a step of receiving data streams from a plurality of mobile smart devices from a plurality of users, the data streams recording information about users' daily lives. Intervention signals are sent to a user in response to data acquired from two or more individuals and interpreted with respect to user internal states, moods, emotions, predetermined behaviors, and interactions with other users. |
| FILED | Monday, June 27, 2022 |
| APPL NO | 17/849996 |
| CURRENT CPC | Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 19/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220328764 | Taylor et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NEW YORK UNIVERSITY (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | André D. Taylor (Brooklyn, New York); Jaemin Kong (Gyeongsangnam-do, South Korea); Jason Alexander Rohr (Brooklyn, New York) |
| ABSTRACT | A doped organic semiconductor is produced using the method of providing an organic semiconductor solution, contacting the organic semiconductor solution with CO2; and irradiating the organic semiconductor solution with ultraviolet light. A composition is described, the composition comprising an organic semiconductor; and a metal salt having the formula M+X− wherein X− is a monoanionic species; and wherein the ratio of M+ to X− in the hole transport material is less than about 1.00. An additional composition is described, the composition comprising an organic semiconductor; a metal salt having the formula M+X− wherein X− is a monoanionic species; and a metal carbonate; wherein the total metal content of the composition is approximately equal to the X− content of the composition. |
| FILED | Thursday, March 31, 2022 |
| APPL NO | 17/709522 |
| CURRENT CPC | Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 9/2009 (20130101) H01G 9/2018 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/005 (20130101) H01L 51/006 (20130101) Original (OR) Class H01L 51/0056 (20130101) H01L 51/4253 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220328802 | Watkins et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James J. Watkins (South Hadley, Massachusetts); Wenhao Li (Sunderland, Massachusetts) |
| ABSTRACT | Various embodiments disclosed relate to novel methods of fabricating 3-D Li ion batteries using direct nanoimprint lithography. The present invention includes methods of fabricating high surface area electrodes, including imprint patterning of high aspect ratio parallel grating style electrodes. The method includes coating a substrate with an ink containing nanoparticles and subsequently annealing the ink into a desired pattern. |
| FILED | Wednesday, June 22, 2022 |
| APPL NO | 17/808229 |
| CURRENT CPC | Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/0002 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/131 (20130101) H01M 4/366 (20130101) H01M 4/0404 (20130101) H01M 4/0433 (20130101) Original (OR) Class H01M 4/0471 (20130101) H01M 4/505 (20130101) H01M 4/622 (20130101) H01M 4/1391 (20130101) H01M 10/058 (20130101) H01M 10/0525 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220329988 | Zhu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Research Foundation of the City University of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhigang Zhu (Princeton, New York); Jin Chen (New York, New York); Hao Tang (New York, New York); Arber Ruci (Ridgewood, New York) |
| ABSTRACT | An indoor navigation system comprises a modeling subsystem that processes multimodal data regarding a location, individually generates a model of each of a plurality of overlapping local regions subdivided from the location, and maps the model of each region and a coordinate system of the model aligned with a floor plan of the location, and a navigation subsystem that processes the model to plot a path at the location for navigating a user along the path in real-time. |
| FILED | Wednesday, August 11, 2021 |
| APPL NO | 17/399457 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/206 (20130101) Wireless Communication Networks H04W 4/029 (20180201) H04W 4/33 (20180201) Original (OR) Class H04W 4/80 (20180201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220330050 | Osinski et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | AT and T Intellectual Property I, L.P. (Atlanta, Georgia); AT and T Mobility II LLC (Atlanta, Georgia); Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | AT and T Intellectual Property I, L.P. (Atlanta, Georgia); AT and T Mobility II LLC (Atlanta, Georgia); Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Matthew Osinski (Westfield, New Jersey); JIA WANG (Basking Ridge, New Jersey); Zihui Ge (Madison, New Jersey); Anthony Caracciolo (E.Brunswick, New Jersey); Chandra Thompson (College Park, Georgia); Benjamin Grizzle (Yukon, Oklahoma); Eric Bonitz (Pueblo, Colorado); Hendrik Hofman (Danville, California); Sonia Fahmy (West Lafayette, Indiana); Chunyi Peng (West Lafayette, Indiana); Bruno Ribeiro (West Lafayette, Indiana); Amit Kumar Sheoran (West Lafayette, Indiana) |
| ABSTRACT | Aspects of the subject disclosure may include, for example, automatically detecting a service issue of a telecommunication system that may impact a customer of a telecommunication service provider of the telecommunication system, predicting, by the processing system, a future customer care interaction by the customer as a result of the service issue, initiating a resolution action of the telecommunication system for the service issue before the customer contacts a customer care agent of the telecommunication service provider, wherein the initiating is responsive to the predicting the future customer care interaction and modifying a component of the telecommunication system to improve efficiency of operation of the telecommunication system by reducing a number of customer care contacts by customers of the telecommunication service provider. Other embodiments are disclosed. |
| FILED | Wednesday, June 22, 2022 |
| APPL NO | 17/846246 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 30/016 (20130101) Telephonic Communication H04M 3/4217 (20130101) H04M 3/5175 (20130101) H04M 15/886 (20130101) Wireless Communication Networks H04W 8/18 (20130101) H04W 24/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220330259 | Jamieson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Mohammad Mazaheri (Waterloo, Canada); Omid Abari (Los Angeles, California); The Trustees of Princeton University (Princeton, New Jersey); University of Massachusetts (Hadley, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kyle Jamieson (Princeton, New Jersey); Kun Woo Cho (Princeton, New Jersey); Mohammad Mazaheri (Waterloo, Canada); Jeremy Gummeson (Belchertown, Massachusetts); Omid Abari (Los Angeles, California) |
| ABSTRACT | Use of high frequency waves, such a millimeter waves, in many circumstances is prevented due to their inability to diffract around common obstacles. Disclosed herein is a system and method for transforming an incident high frequency wave. The system includes meta-atom pairs that define a surface. The meta-atom pairs generate an electro-magnetic response by interacting with an incident wave. This electro-magnetic response can be modulated by applying voltage to the meta-atom pairs. The electro-magnetic response transforms the incident wave into an emitted wave based on its controlled properties. The system and method are able to, by changing the voltage applied, steer the emitted wave a full 360 degrees as wells as transmit it through the surface without significant power loss. Embodiments enable the transmission through or around many obstacles that would normally interfere with high frequency waves. |
| FILED | Thursday, March 31, 2022 |
| APPL NO | 17/710772 |
| CURRENT CPC | Transmission H04B 17/13 (20150115) H04B 17/391 (20150115) Wireless Communication Networks H04W 72/046 (20130101) H04W 72/085 (20130101) Original (OR) Class H04W 72/0453 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20220324024 | van Rooyen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Isabella J. van Rooyen (Idaho Falls, Idaho); Piyush Sabharwal (Idaho Falls, Idaho) |
| ABSTRACT | A method of forming at least a component of a heat exchanger comprises introducing a feed material comprising a first portion including a matrix material and a second portion including a sacrificial material on a surface of a substrate, exposing at least the first portion to energy to form bonds between particles of the matrix material and form a first thickness of a structure, introducing additional feed material comprising the first portion over the first thickness of the structure, exposing the additional feed material to energy to form a second thickness of the structure, and removing the sacrificial material from the structure to form at least one channel in the structure. Related heat exchangers and components, and related methods are disclosed. |
| FILED | Tuesday, June 14, 2022 |
| APPL NO | 17/806916 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/20 (20210101) Original (OR) Class Metal-working Not Otherwise Provided For; Combined Operations; Universal Machine Tools B23P 15/26 (20130101) Shaping Clay or Other Ceramic Compositions; Shaping Slag; Shaping Mixtures Containing Cementitious Material, e.g Plaster B28B 1/001 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) B33Y 80/00 (20141201) Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 21/04 (20130101) F28F 21/081 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220324779 | Ebikade et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Elvis O. Ebikade (Washington, District of Columbia); Eric R. Gottlieb (Newark, Delaware); Robert M. O'Dea (Newark, Delaware); Thomas H. Epps, III (Bear, Delaware); Dionisios Vlachos (Newark, Delaware) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elvis O. Ebikade (Washington, District of Columbia); Eric R. Gottlieb (Newark, Delaware); Robert M. O'Dea (Newark, Delaware); Thomas H. Epps, III (Bear, Delaware); Dionisios Vlachos (Newark, Delaware) |
| ABSTRACT | Disclosed herein are systems and methods of depolymerizing a lignin component of a lignin-containing material. The method comprising contacting the lignin-containing material with a solvent and optionally a catalyst at a temperature in the range of 180-300° C. and at a maximum operating pressure of less than 10 barG during the depolymerization of the lignin component of the material and collecting at least one volatile stream comprising one or more depolymerized lignin products. In an embodiment, the step of contacting is carried out in a reactive distillation reactor, and the step of collecting comprises concurrently collecting at least one volatile stream via distillation apparatus connected to the reactive distillation reactor, at least one of the one or more depolymerized lignin products comprises a substituted phenol having the following general formula: (I) wherein R1 is H, methyl, ethyl, n-propyl, propenyl, or allyl, and R2 and R3 are independently selected from H or methoxy group. |
| FILED | Friday, August 14, 2020 |
| APPL NO | 17/634271 |
| CURRENT CPC | Separation B01D 3/009 (20130101) B01D 36/00 (20130101) Acyclic or Carbocyclic Compounds C07C 37/004 (20130101) Original (OR) Class C07C 41/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220325501 | KOCI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Caterpillar Inc. (Peoria, Illinois) |
| ASSIGNEE(S) | Caterpillar Inc. (Peoria, Illinois) |
| INVENTOR(S) | Chad KOCI (Washington, Illinois); Jay R. STEFFEN (Washington, Illinois); Fang GUO (Dunlap, Illinois); Richard W. KRUISWYK (Dunlap, Illinois); Gaurav VASUDEVA (Dunlap, Illinois); Robert Michael MCDAVID (Dunlap, Illinois); Timothy Adam BAZYN (Chilicothe, Illinois) |
| ABSTRACT | A power system may include a high-speed flywheel connected to an engine of a machine; a battery; a motor-generator unit (MGU) connected to the engine and the battery; and a turbocharger connected to the engine. One or more of the high-speed flywheel, the battery and the MGU, or the turbocharger may be configured to provide supplemental power to power provided by the engine to operate the machine, or provide replacement power when no power is provided by the engine to operate the machine. |
| FILED | Friday, April 09, 2021 |
| APPL NO | 17/301651 |
| CURRENT CPC | Dredging; Soil-shifting E02F 9/202 (20130101) E02F 9/2075 (20130101) Original (OR) Class E02F 9/2091 (20130101) E02F 9/2095 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220325658 | Koci et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Caterpillar Inc. (Peoria, Illinois) |
| ASSIGNEE(S) | Caterpillar Inc. (Peoria, Illinois) |
| INVENTOR(S) | Chad Palmer Koci (Washington, Illinois); Yongli Qi (Peoria, Illinois); Jason Jon Rasmussen (Hopewell, Illinois); Daniel J. Sordelet (Peoria, Illinois) |
| ABSTRACT | Operating an engine includes moving a piston in a combustion chamber between a bottom dead center position and a top dead center position in an engine cycle. A fuel is injected into the combustion chamber through a plurality of sets of nozzle outlets varied set-to-set with respect to outlet size and spray angle. Spray jets of the injected fuel are propagated in an impingement-limiting fuel spray pattern that is based on the set-to-set variation in outlet size and spray angle so as to limit dissipation of heat from combustion of the injected fuel to material of the engine by way of a thermal barrier coating (TBC) upon a surface of the combustion chamber. |
| FILED | Tuesday, April 13, 2021 |
| APPL NO | 17/229446 |
| CURRENT CPC | Internal-combustion Piston Engines; Combustion Engines in General F02B 23/0651 (20130101) Original (OR) Class F02B 23/0669 (20130101) F02B 23/0696 (20130101) F02B 2275/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220325671 | Yun et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GM Global Technology Operations LLC (Detroit, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hanho Yun (Oakland Twp, Michigan); Jun-mo Kang (Ann Arbor, Michigan) |
| ABSTRACT | A method of transient control for enrichment operation in a low-temperature combustion engine. The method includes determining if a current mode of the low-temperature combustion (LTC) engine is a positive valve overlap (PVO) mode. Determining if a previous mode of the LTC engine was also the PVO mode when the current mode is the PVO mode, wherein the previous mode is immediately prior to the current mode. Determining if the previous mode of the LTC engine was a negative valve overlap (NVO) mode when the previous mode was not the PVO mode. Initiating a predetermined enrichment PVO mode for the LTC engine based on the previous mode of the LTC engine. The predetermined enrichment PVO mode includes initiating a deep enrichment PVO mode, when the previous mode of the LTC engine was the NVO mode, and initiating a shallow enrichment PVO mode, when the previous mode of the LTC engine was not the NVO mode. |
| FILED | Tuesday, April 13, 2021 |
| APPL NO | 17/229418 |
| CURRENT CPC | Controlling Combustion Engines F02D 13/0261 (20130101) Original (OR) Class F02D 41/0235 (20130101) F02D 41/1475 (20130101) F02D 2200/08 (20130101) F02D 2200/1002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220325688 | Duquette et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | LITTORAL POWER SYSTEMS, INC. (New Bedford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David J. Duquette (Fairhaven, Massachusetts); Kimbal Anderson Hall (Princeton, Massachusetts) |
| ABSTRACT | Systems and method for a hydrokinetic energy device. A hydrokinetic energy device includes a main body including two main wing-shaped spars mounted upon a rotating central hub, and rotatable spar tip turbines mounted at or near an end of each of the main wing-shaped spars, the main wing-shaped spars driving the rotatable spar tip turbines through water, each of the rotatable spar tip turbines including a direct-drive generator and power conversion system that transfers power from a rotating rotatable spar tip turbine to the central hub where the voltage is stepped up and amperage is reduced. |
| FILED | Thursday, June 16, 2022 |
| APPL NO | 17/842468 |
| CURRENT CPC | Machines or Engines for Liquids F03B 3/121 (20130101) Original (OR) Class F03B 11/02 (20130101) F03B 11/06 (20130101) Indexing Scheme Relating to Wind, Spring, Weight, Inertia or Like Motors, to Machines or Engines for Liquids Covered by Subclasses F03B, F03D and F03G F05B 2220/706 (20130101) F05B 2240/917 (20130101) F05B 2260/90 (20130101) Dynamo-electric Machines H02K 7/1823 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220326082 | BEARD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Craig BEARD (Arvada, Colorado); Jeffrey Lee BLACKBURN (Golden, Colorado); Ji HAO (Santa Clara, California); Haipeng LU (Hong Kong, China PRC) |
| ABSTRACT | The present disclosure relates to a composition that includes a first layer having a first molecule that includes a metal and a halogen, a second layer that includes the first molecule, and a third layer that includes a chiral molecule, where the third layer is positioned between the first layer and the second layer, and the first layer, the second layer, and the third layer form a crystalline structure. |
| FILED | Friday, March 04, 2022 |
| APPL NO | 17/653470 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 4/04 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0035 (20130101) H01L 51/0048 (20130101) H01L 51/0091 (20130101) H01L 51/424 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220326147 | MALLERY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | REBELLION PHOTONICS, INC. (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan MALLERY (Houston, Texas); Ohad Israel BALILA (Friendswood, Texas); Robert Timothy KESTER (Friendswood, Texas) |
| ABSTRACT | An infrared (IR) imaging system for determining a concentration of a target species in an object is disclosed. The imaging system can include an optical system including a focal plane array (FPA) unit behind an optical window. The optical system can have components defining at least two optical channels thereof, said at least two optical channels being spatially and spectrally different from one another. Each of the at least two optical channels can be positioned to transfer IR radiation incident on the optical system towards the optical FPA. The system can include a processing unit containing a processor that can be configured to acquire multispectral optical data representing said target species from the IR radiation received at the optical FPA. One or more of the optical channels may be used in detecting objects on or near the optical window, to avoid false detections of said target species. |
| FILED | Wednesday, June 22, 2022 |
| APPL NO | 17/808273 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 5/0806 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/314 (20130101) G01N 21/3504 (20130101) Original (OR) Class Pictorial Communication, e.g Television H04N 5/33 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220326150 | McCartt et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel McCartt (Johnson City, Tennessee); Jun Jiang (Fremont, California) |
| ABSTRACT | In one aspect, a method of detecting a trace gas is disclosed. The method includes containing the trace gas in an optical cavity. The method further includes injecting a first laser light from a first laser into the optical cavity causing the trace gas to transition from an energy state lower that a first excited energy state to the first excited energy state, and injecting a second laser light from a second laser into the optical cavity causing the trace gas to transition from the first excited energy state to a second excited energy state. The method includes measuring, by a detector, a first cavity ringdown intensity as a function of time after turning off the second laser with the first laser on, and a second cavity ringdown intensity as a function of time after turning off the second laser with the first laser off. |
| FILED | Wednesday, March 30, 2022 |
| APPL NO | 17/709222 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/42 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/39 (20130101) Original (OR) Class G01N 2021/391 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220326399 | BRODSKY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason Philip BRODSKY (Livermore, California); Nathaniel Sean BOWDEN (Livermore, California) |
| ABSTRACT | The present disclosure relates to a method for detecting incoming radiation having a plurality of differing properties including at least one of differing types, differing energies or differing incoming directions. The method involves using a scintillator structure formed from first and second dissimilar scintillator materials, where the first and second dissimilar scintillator materials emit first and second different colors of light in response to the incoming radiation. A first light detector is used for detecting light having the first color, and a second light detector is used for detecting light having the second color. A first output signal is generated in response to the detection of light having the first color, and a second output signal is generated in response to detecting light having the second color. The first and second output signals are then analyzed to determine at least one property of the incoming radiation. |
| FILED | Tuesday, June 21, 2022 |
| APPL NO | 17/845322 |
| CURRENT CPC | Measurement of Nuclear or X-radiation G01T 1/201 (20130101) G01T 1/2002 (20130101) G01T 1/2006 (20130101) Original (OR) Class G01T 1/2033 (20130101) G01T 3/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220326499 | Wiederrecht et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Gary P. Wiederrecht (Elmhurst, Illinois); Stephen K. Gray (Wheaton, Illinois); Xiewen Wen (Willowbrook, Illinois); Sushovit Adhikari (Westmont, Illinois); Cristian Leonardo Cortes (Chicago, Illinois); David J. Gosztola (Naperville, Illinois) |
| ABSTRACT | A system and methods for ghost imaging second harmonic generation microscopy. Imaging data is collected in parallel, providing faster imagine reconstruction and enabling reconstruction in scattering environments. Ghost imaging, split light beam interacting with a target and a second light beam unimpeded and not required to pass through the same background. A second harmonic generation image is reconstructed from the detected photons. |
| FILED | Friday, April 09, 2021 |
| APPL NO | 17/226734 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/2823 (20130101) Optical Elements, Systems, or Apparatus G02B 21/18 (20130101) Original (OR) Class Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/37 (20130101) Image Data Processing or Generation, in General G06T 5/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220326722 | KISHORE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ravi Anant KISHORE (Lakewood, Colorado); Sampath KOMMANDUR (Golden, Colorado); Charles William BOOTEN (Arvada, Colorado); Lance Michael WHEELER (Wheat Ridge, Colorado); Shuang CUI (Dallas, Texas) |
| ABSTRACT | The present disclosure relates to a directional heat transfer using thermal control devices, including a dual phase change thermal diode and an active contact-based thermal switch. The thermal diode includes a positive temperature coefficient switching material and a negative temperature coefficient switching material arranged in series. The thermal switch includes two thermally conducting surfaces which may be moved to contact (i.e., having a distance between them of substantially zero) creating minimal thermal contact resistance. Both thermal control devices may be used to control heat flow into and/or out of a building. |
| FILED | Thursday, April 07, 2022 |
| APPL NO | 17/715144 |
| CURRENT CPC | Systems for Controlling or Regulating Non-electric Variables G05D 23/121 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220327204 | ABBASZADEH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Masoud ABBASZADEH (Clifton Park, New York); Weizhong YAN (Clifton Park, New York); Justin Varkey JOHN (Cohoes, New York); Matthew Christian NIELSEN (Soctia, New York) |
| ABSTRACT | According to some embodiments, a system, method and non-transitory computer readable medium are provided comprising a plurality of real-time monitoring nodes to receive streams of monitoring node signal values over time that represent a current operation of the cyber physical system; a local status determination module comprising an ensemble of local agents, the module adapted to determine an anomaly status for one or more nodes; a global status determination module comprising an ensemble of global agents, the module adapted to determine an anomaly status for the cyber physical system; a threat detection computer platform comprising a memory and a computer processor, the threat detection computer platform coupled to the plurality of real-time monitoring nodes and adapted to: receive the monitoring node signal values, generate feature vectors from the received monitoring node signal values; compare via the local status determination module the feature vectors with at least one decision boundary associated with a local abnormal detection model; compare via the global status determination module the feature vectors with at least one decision boundary associated with a global abnormal detection model; and transmit an abnormal alert signal from the local status determination module and the global status determination module based on a result of each comparison. Numerous other aspects are provided. |
| FILED | Monday, April 12, 2021 |
| APPL NO | 17/228162 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/554 (20130101) Original (OR) Class G06F 2221/034 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220327949 | Bertolli |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Avrio Analytics LLC (Knoxville, Tennessee) |
| ASSIGNEE(S) | Avrio Analytics LLC (Knoxville, Tennessee) |
| INVENTOR(S) | Michael G. Bertolli (Knoxville, Tennessee) |
| ABSTRACT | A method for providing task load-optimized computer-generated training experiences to a user of a training system that includes: a display, a training simulator, a prediction program (ML1), and a training optimization program (ML2). In response to receiving a predicted optimal task load, ML2 provides a first training experience recommendation related to the training content and/or training conditions that, if utilized in providing a training experience to the user, is predicted to result in the predicted actual task load of the user equaling the predicted optimal task load. In response to receiving biometric information or performance metric information, ML1 determines the predicted actual task load. If the predicted actual task load does not match the predicted optimal task load, ML2 provides a second training experience recommendation and a second training experience is provided where at least one of the training content or the training conditions is changed. |
| FILED | Monday, February 07, 2022 |
| APPL NO | 17/666228 |
| CURRENT CPC | Fire-fighting A62C 99/0081 (20130101) Computer Systems Based on Specific Computational Models G06N 5/04 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 9/00 (20130101) Original (OR) Class G09B 19/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220328375 | Schultz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark D. Schultz (Ossining, New York); Fuad Elias Doany (Katonah, New York); Benjamin Giles Lee (Ridgefield, Connecticut); Daniel M. Kuchta (Patterson, New York); Christian Wilhelmus Baks (Pleasant Valley, New York) |
| ABSTRACT | An optical module includes an optoelectronic assembly and a heat spreader. The optoelectronic assembly includes a flat, rigid substrate, an array of electrical contacts positioned on a first portion of the substrate, and an optoelectronics assemblage that is electrically connected to the array of contacts and is positioned apart from the array of electrical contacts. The heat spreader is comprised of a thermally conductive material and comprises a second portion that is structurally connected to the first portion and a third portion that is thermally connected to the optoelectronics assemblage. |
| FILED | Wednesday, April 07, 2021 |
| APPL NO | 17/225075 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/4269 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/3675 (20130101) Original (OR) Class H01L 23/49833 (20130101) H01L 25/167 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220328764 | Taylor et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NEW YORK UNIVERSITY (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | André D. Taylor (Brooklyn, New York); Jaemin Kong (Gyeongsangnam-do, South Korea); Jason Alexander Rohr (Brooklyn, New York) |
| ABSTRACT | A doped organic semiconductor is produced using the method of providing an organic semiconductor solution, contacting the organic semiconductor solution with CO2; and irradiating the organic semiconductor solution with ultraviolet light. A composition is described, the composition comprising an organic semiconductor; and a metal salt having the formula M+X− wherein X− is a monoanionic species; and wherein the ratio of M+ to X− in the hole transport material is less than about 1.00. An additional composition is described, the composition comprising an organic semiconductor; a metal salt having the formula M+X− wherein X− is a monoanionic species; and a metal carbonate; wherein the total metal content of the composition is approximately equal to the X− content of the composition. |
| FILED | Thursday, March 31, 2022 |
| APPL NO | 17/709522 |
| CURRENT CPC | Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 9/2009 (20130101) H01G 9/2018 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/005 (20130101) H01L 51/006 (20130101) Original (OR) Class H01L 51/0056 (20130101) H01L 51/4253 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220328800 | Belharouak et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ilias Belharouak (Oak Ridge, Tennessee); Yaocai Bai (Oak Ridge, Tennessee); Rachid Essehli (Oak Ridge, Tennessee); Jianlin Li (Oak Ridge, Tennessee) |
| ABSTRACT | A method for the regeneration of cathode material from spent lithium-ion batteries is provided. The method includes dissolving a lithium precursor in a polyhydric alcohol to form a solution. Degraded cathode material containing lithium metal oxides are dispersed into the solution under mechanical stirring, forming a mixture. The mixture is heat treated within a reactor vessel or microwave oven. During this heat treatment, lithium is intercalated into the degraded cathode material. The relithiated electrode material is collected by filtration, washing with solvents, and drying. The relithiated electrode material is then ground with a lithium precursor and thermally treated at a relatively low temperature for a predetermined time period to obtain regenerated cathode material. |
| FILED | Wednesday, June 30, 2021 |
| APPL NO | 17/363272 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/049 (20130101) Original (OR) Class H01M 4/0471 (20130101) H01M 10/0525 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220328865 | Visco et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PolyPlus Battery Company (Berkeley, California) |
| ASSIGNEE(S) | PolyPlus Battery Company (Berkeley, California) |
| INVENTOR(S) | Steven J. Visco (Berkeley, California); Yevgeniy S. Nimon (Danville, California); Lutgard C. De Jonghe (Lafayette, California); Bruce D. Katz (Moraga, California); Vitaliy Nimon (San Francisco, California) |
| ABSTRACT | A lithium ion-conductive solid electrolyte including a freestanding inorganic vitreous sheet of sulfide-based lithium ion conducting glass is capable of high performance in a lithium metal battery by providing a high degree of lithium ion conductivity while being highly resistant to the initiation and/or propagation of lithium dendrites. Such an electrolyte is also itself manufacturable, and readily adaptable for battery cell and cell component manufacture, in a cost-effective, scalable manner. An automated machine based system, apparatus and methods assessing and inspecting the quality of such vitreous solid electrolyte sheets, electrode sub-assemblies and lithium electrode assemblies can be based on spectrophotometry and can be performed inline with fabricating the sheet or web (e.g., inline with drawing of the vitreous Li ion conducting glass) and/or with the manufacturing of associated electrode sub-assemblies and lithium electrode assemblies and battery cells. |
| FILED | Monday, March 14, 2022 |
| APPL NO | 17/654648 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/31 (20130101) G01N 21/896 (20130101) G01N 21/8422 (20130101) G01N 21/8914 (20130101) G01N 2021/8967 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/134 (20130101) H01M 4/0407 (20130101) H01M 4/1395 (20130101) H01M 10/0525 (20130101) H01M 10/0562 (20130101) Original (OR) Class H01M 10/0566 (20130101) H01M 50/46 (20210101) H01M 50/403 (20210101) H01M 50/431 (20210101) H01M 2300/0068 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220328866 | Visco et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PolyPlus Battery Company (Berkeley, California) |
| ASSIGNEE(S) | PolyPlus Battery Company (Berkeley, California) |
| INVENTOR(S) | Steven J. Visco (Berkeley, California); Yevgeniy S. Nimon (Danville, California); Bruce D. Katz (Moraga, California) |
| ABSTRACT | An intermediary solid electrolyte structure having a Li ion conducting solid electrolyte layer with a thin phosphorus nitride film covering provides protection of the solid electrolyte surfaces against reaction with moisture during sulfide glass solid electrolyte storage, transportation, and cell assembly in a dry room atmosphere. |
| FILED | Friday, April 08, 2022 |
| APPL NO | 17/658639 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/382 (20130101) H01M 4/0407 (20130101) H01M 10/0562 (20130101) Original (OR) Class H01M 2300/0068 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220328881 | Takeuchi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States Department of Energy (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Esther S. Takeuchi (South Setauket, New York); Kenneth J. Takeuchi (South Setauket, New York); Amy C. Marschilok (Stony Brook, New York); David C. Bock (Shoreham, New York) |
| ABSTRACT | One or more embodiments relates to a solvent that includes a first fluorinated ester, a diluent, a salt. One or more embodiments may include a film-forming additive. The diluent may include a second fluorinated ester or a fluorinated ether. Further, the solvent to diluent ratio is from about 1:0.2 to about 1:10. |
| FILED | Tuesday, April 12, 2022 |
| APPL NO | 17/718512 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0525 (20130101) H01M 10/0567 (20130101) H01M 10/0568 (20130101) H01M 10/0569 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220329048 | KOTOVSKY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California); Colorado State University Research Foundation (Fort Collins, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jack KOTOVSKY (Alameda, California); Salmaan H. BAXAMUSA (Livermore, California); Clint D. FRYE (Livermore, California); Ian Seth LADNER (Livermore, California); Thomas M. SPINKA (Livermore, California); Devin Joseph FUNARO (Livermore, California); David Ryan HOBBY (Wellington, Colorado); Caleb Del ANDERSON (Fort Collins, Colorado); Todd BANDHAUER (Fort Collins, Colorado) |
| ABSTRACT | The present disclosure relates to a laser diode system. The system may have at least one laser diode emitter having a substrate, at least one laser diode supported on the substrate, and a facet which a laser beam generated by the laser diode is emitted. A cooling subsystem is included which is disposed in contact with the substrate of the laser diode emitter. The cooling subsystem includes a plurality of cooling fins forming a plurality of elongated channels for circulating a cooling fluid therethrough to cool the laser diode emitter. The cooling fluid also flows over the facet of the laser diode emitter. |
| FILED | Friday, April 09, 2021 |
| APPL NO | 17/227132 |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/02423 (20130101) H01S 5/4025 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220329521 | Roweth et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Hewlett Packard Enterprise Development LP (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Duncan Roweth (Bristol Avon, United Kingdom); Joseph G. Kopnick (Chippewa Falls, Wisconsin); Andrew S. Kopser (Seattle, Washington); Edwin L. Froese (Burnaby British Columbia, Canada) |
| ABSTRACT | Systems and methods are provided for performing routing in a switch network or fabric. Switches can be configured in a hierarchical topology having a plurality of groups, where switches in a group are connected to one another, and groups are connected to other groups. Routing can be performed by maintaining per-group group load information. A packet can be routed between at least two groups using the per-group group load information to effect a set of routing decisions. The set of routing decisions can be biased towards or away one or more paths. |
| FILED | Monday, March 23, 2020 |
| APPL NO | 17/594609 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 43/0876 (20130101) H04L 45/46 (20130101) H04L 45/70 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220329613 | ABBASZADEH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Masoud ABBASZADEH (Clifton Park, New York); Matthew Christian NIELSEN (Scotia, New York); Weizhong YAN (Clifton Park, New York); Justin Varkey JOHN (Cohoes, New York) |
| ABSTRACT | According to some embodiments, a system, method, and non-transitory computer readable medium are provided comprising a plurality of real-time monitoring nodes to receive streams of monitoring node signal values over time that represent a current operation of the cyber physical system; and a threat detection computer platform, coupled to the plurality of real-time monitoring nodes, to: receive the monitoring node signal values; compute an anomaly score; compare the anomaly score with an adaptive threshold; and detect that one of a particular monitoring node and a system is outside a decision boundary based on the comparison, and classify that particular monitoring node or system as anomalous. Numerous other aspects are provided. |
| FILED | Monday, April 12, 2021 |
| APPL NO | 17/228191 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 63/1416 (20130101) H04L 63/1425 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20220322647 | Lauth et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Center for Aquaculture Technologies, Inc. (San Diego, California) |
| ASSIGNEE(S) | Center for Aquaculture Technologies, Inc. (San Diego, California) |
| INVENTOR(S) | Xavier Christophe Lauth (San Diego, California); John Terrell Buchanan (San Diego, California) |
| ABSTRACT | The disclosure provides a method of generating a sterile fish, crustacean, or mollusk. The method comprises breeding (i) a fertile hemizygous mutated female fish, crustacean, or mollusk with (ii) a fertile hemizygous mutated male fish, crustacean, or mollusk, selecting a female progenitor that is homozygous by genotypic selection, and breeding the homozygous female progenitor to produce the sterile fish, crustacean, or mollusk. The mutation disrupts the maternal-effect of a primordial germ cell (PGC) development gene and does not impair the viability, sex determination, fertility, or a combination thereof, of a homozygous progenitor. The disclosure also provides methods of making broodstock freshwater and seawater organisms for use in producing sterilized freshwater and seawater organisms, as well as the broodstock itself. |
| FILED | Friday, July 19, 2019 |
| APPL NO | 17/261280 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0275 (20130101) Original (OR) Class A01K 67/0334 (20130101) A01K 67/0338 (20130101) A01K 2217/15 (20130101) A01K 2217/058 (20130101) A01K 2217/075 (20130101) A01K 2227/40 (20130101) A01K 2227/70 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220322693 | Harte et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Federico Miguel Harte (Port Matilda, Pennsylvania); Michelle Tran (Winnipeg, Canada); John Coupland (State College, Pennsylvania); Robert Roberts (State College, Pennsylvania); Greg Ziegler (State College, Pennsylvania) |
| ABSTRACT | Compositions and methods that relate to improved chocolate milk are provided. The chocolate milk may be shelf stable and k-carrageenan free. The chocolate milk does not undergo visually detectable phase separation for at least 7 days. The chocolate milk that does not undergo the visually detectable phase separation contains from 1%-10% micellar casein w/v. Methods for preparing shelf stable k-carrageenan free chocolate milk are also provided and include mixing cocoa powder, sugar, milk, and micellar casein to obtain a mixture, and optionally heating and homogenizing the mixture, and subsequently subjecting the mixture to High Pressure Jet Processing (HPJ) or high pressure homogenization of at least 300 MPa, thereby producing the shelf table k-carrageenan free chocolate milk. The shelf stable k-carrageenan free chocolate milk of produced using such a method may be refrigerated temperature for at least 14 days, and does not undergo detectable phase separation for at least 14 days. |
| FILED | Friday, June 17, 2022 |
| APPL NO | 17/807696 |
| CURRENT CPC | Cocoa; Cocoa Products, e.g Chocolate; Substitutes for Cocoa or Cocoa Products; Confectionery; Chewing Gum; Ice-cream; Preparation Thereof A23G 1/46 (20130101) A23G 1/56 (20130101) Original (OR) Class Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) A23V 2250/60 (20130101) A23V 2250/54246 (20130101) A23V 2300/24 (20130101) A23V 2300/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220322719 | Mastaloudis et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NSE Products, Inc. (Provo, Utah) |
| ASSIGNEE(S) | NSE Products, Inc. (Provo, Utah) |
| INVENTOR(S) | Angela Mastaloudis (Holladay, Utah); Steven M. Wood (Santaquin, Utah); Shelly Hester (Draper, Utah); Mark Bartlett (Orem, Utah) |
| ABSTRACT | Compositions for promoting intestinal health are disclosed and described. In one example, the composition can include a combination of cyanidins and delphinidins, in an amount sufficient to treat intestinal hyperpermeability. In a further example, the composition can further comprise a prebiotic blend and fructooligosaccharides. Further presented herein, is a method of treating a condition or disorder related to gastrointestinal health in a subject. In one example, the method can include maximizing tight junction integrity in epithelial cells of gastrointestinal tract of the subject. |
| FILED | Tuesday, March 15, 2022 |
| APPL NO | 17/695574 |
| CURRENT CPC | Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 33/127 (20160801) A23L 33/135 (20160801) Original (OR) Class Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) Indexing Scheme Relating to Lactic or Propionic Acid Bacteria Used in Foodstuffs or Food Preparation A23Y 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/14 (20180101) A61P 5/50 (20180101) A61P 9/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220323634 | Edwards et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia); H and H Medical Corporation (Williamsburg, Virginia); Virginia Commonwealth University (Richmond, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Judson V. Edwards (Abita Springs, Louisiana); Nicolette T. Prevost (Prairieville, Louisiana); Elena E. Graves (METAIRIE, Louisiana); Joseph Dacorta (King George, Virginia); Dorne Yager (Mechanicsville, Virginia) |
| ABSTRACT | The invention relates to fabric compositions with improved hemostatic properties comprising attached a zeolite, a zeolite/pectin complex, or a mixture thereof, and methods of preparing such fabric compositions. |
| FILED | Tuesday, April 05, 2022 |
| APPL NO | 17/713803 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 15/40 (20130101) A61L 15/44 (20130101) Original (OR) Class A61L 2300/102 (20130101) A61L 2400/04 (20130101) Treatment, Not Provided for Elsewhere in Class D06, of Fibres, Threads, Yarns, Fabrics, Feathers or Fibrous Goods Made From Such Materials D06M 10/06 (20130101) D06M 10/10 (20130101) D06M 11/45 (20130101) D06M 11/77 (20130101) D06M 15/03 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220323635 | Edwards et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia); H and H Medical Corporation (Williamsburg, Virginia); Virginia Commonwealth University (Richmond, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Judson V. Edwards (Abita Springs, Louisiana); Nicolette T. Prevost (Prairieville, Louisiana); Elena E. Graves (METAIRIE, Louisiana); Joseph Dacorta (King George, Virginia); Dorne Yager (Mechanicsville, Virginia) |
| ABSTRACT | The invention relates to antimicrobial and/or antiviral fabric compositions comprising ascorbic acid, citric acid, sodium hypophosphite, or a mixture thereof. The ascorbic acid may be covalently attached to at least one cellulosic portion of the fabric composition. The invention also relates to methods for preparing such fabric compositions. |
| FILED | Tuesday, April 05, 2022 |
| APPL NO | 17/713871 |
| CURRENT CPC | Outerwear; Protective Garments; Accessories A41D 13/1192 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 15/40 (20130101) A61L 15/44 (20130101) Original (OR) Class A61L 2300/21 (20130101) A61L 2300/112 (20130101) A61L 2300/216 (20130101) A61L 2300/404 (20130101) A61L 2300/408 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220325329 | ARMSTRONG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | CHERYL M. ARMSTRONG (ABINGTON, Pennsylvania); JOSEPH A. CAPOBIANCO, JR. (MARLTON, New Jersey); ANDREW G. GEHRING (RESHER, Pennsylvania); JOSEPH LEE (FLEMINGTON, New Jersey) |
| ABSTRACT | A flow-through electrochemical detection system determines if a target nucleic acid polymer is present in a sample. This system contains, at a minimum, an assay reaction chamber that contains a porous working electrode to which target nucleic acid polymer capturing molecules are bound. As a sample passes through the working electrode, any target nucleic acid polymer present in the sample binds to the target nucleic acid polymer capturing molecules. After the sample passes through the flow-through electrochemical detection system, target nucleic acid polymer detectors are placed inside the assay reaction chamber and bind to any target nucleic acid polymer present. The target nucleic acid polymer detectors contain a means for generating an electric current when exposed to a chemical or an enzyme. A potentiostat connected to the working electrode measures the generated current, thereby detecting the presence and quantity of the target nucleic acid polymer in the sample. |
| FILED | Tuesday, March 30, 2021 |
| APPL NO | 17/217495 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) B01L 3/502738 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) C12Q 1/6825 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220325937 | Powell-Palm et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Matthew J. Powell-Palm (Berkeley, California); Boris Rubinsky (Berkeley, California) |
| ABSTRACT | Supercooled water or solutions can be destabilized by the nucleation of ice, which can be triggered by a wide range of different mechanisms. Constraining water in a constant-volume (isochoric) container minimizes the effects of many of these mechanisms through thermodynamic, kinetic, and fluid dynamic means, significantly enhancing supercooling stability. This invention describes methods and devices for high-stability and optionally transportable supercooling of aqueous solutions or suspensions, and the stable and long-term preservation of biological matter that may be stored therein. |
| FILED | Tuesday, June 21, 2022 |
| APPL NO | 17/845114 |
| CURRENT CPC | Refrigerators; Cold Rooms; Ice-boxes; Cooling or Freezing Apparatus Not Otherwise Provided for F25D 3/08 (20130101) Original (OR) Class F25D 2303/084 (20130101) F25D 2331/8014 (20130101) F25D 2700/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220326408 | CHIN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AUBURN UNIVERSITY (Auburn, Alabama); THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bryan A. CHIN (Auburn, Alabama); Henry Allen TORBERT, III (Opelika, Alabama); Galina N. YAKUBOVA (Auburn, Alabama); Aleksandr KAVETSKIY (Auburn, Alabama); Nikolay SARGSYAN (Auburn, Alabama) |
| ABSTRACT | A system for analyzing soil content of a field includes a data acquisition unit configured to detect gamma spectra of each of a plurality of soil samples, wherein a surface area of the field is divided into a plurality of portions and the plurality of soil samples comprises at least one soil sample from each of the plurality of portions, a navigation unit configured to detect geographic coordinates of each of the plurality of soil samples, a data analysis unit configured to associate the detected gamma spectra of each of the plurality of soil samples with the geographic coordinates of the soil sample and determine a weight percent of at least one element within each of the soil samples based on the detected gamma spectra, and an element content map unit configured to generate a map indicating concentration of the at least one element within the soil of the field. |
| FILED | Thursday, June 16, 2022 |
| APPL NO | 17/841952 |
| CURRENT CPC | Planting; Sowing; Fertilising A01C 21/007 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/22 (20130101) G01N 23/221 (20130101) G01N 23/222 (20130101) G01N 23/223 (20130101) G01N 2223/0745 (20130101) Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags G01V 5/0016 (20130101) G01V 5/0066 (20130101) G01V 5/0069 (20161101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20220323005 | Majerus et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steve JA Majerus (University Heights, Ohio); Jeremy Dunning (Cleveland Heights, Ohio); Katherine M. Bogie (Cleveland, Ohio); Joseph A. Potkay (Plymouth, Michigan) |
| ABSTRACT | A sensor apparatus includes at least one substrate layer of an elastically deformable material, the substrate layer extending longitudinally between spaced apart ends thereof. A conductive layer is attached to and extends longitudinally between the spaced apart ends of the at least one substrate layer. The conductive layer includes an electrically conductive material adapted to form a strain gauge having an electrical resistance that varies based on deformation of the conductive layer in at least one direction. |
| FILED | Wednesday, June 24, 2020 |
| APPL NO | 16/910740 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/026 (20130101) A61B 5/683 (20130101) Original (OR) Class A61B 5/02141 (20130101) A61B 5/02444 (20130101) A61B 5/6876 (20130101) A61B 2562/12 (20130101) Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 9/0052 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220323467 | Mohapatra et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of South Florida (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Subhra Mohapatra (Lutz, Florida); Shyam S. Mohapatra (Lutz, Florida); Rinku Dutta (Tampa, Florida); Waise Quarni (Tampa, Florida) |
| ABSTRACT | The present application is directed to pharmaceutical combinations comprising mithramycin and immunotherapy to target cancer initiating stem cells (CSCs). The present application also discloses methods of treating cancer comprising administering mithramycin and immunotherapy to a subject in need thereof. |
| FILED | Tuesday, October 06, 2020 |
| APPL NO | 17/642566 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/704 (20130101) Original (OR) Class A61K 39/3955 (20130101) A61K 2039/54 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 35/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220324956 | Leung et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board Of Trustees Of The Leland Stanford Junior University (Stanford, California); The U.S. Government as represented by the Department of Veterans Affairs (Washinhton, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lawrence L.K. Leung (Hillsborough, California); Michael J. Morser (San Francisco, California); Timothy Myles (Sunnyvale, California) |
| ABSTRACT | Therapeutic antibodies specific for osteopontin and methods of using them for treating osteopontin-associated disorders are provided. In particular, antibodies, or antigen-binding fragments thereof, that inhibit thrombin-cleavage of osteopontin or block the activity of thrombin cleavage fragments of osteopontin are provided. Additionally, antibody conjugates and pharmaceutical compositions or formulations comprising the antibodies or antibody conjugates as well as kits including the antibodies, conjugates, or formulations are also provided. |
| FILED | Friday, August 07, 2020 |
| APPL NO | 17/633797 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/397 (20130101) A61K 31/519 (20130101) A61K 31/4184 (20130101) A61K 47/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/24 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220324998 | O'Bryan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MUSC Foundation for Research Development (Charleston, South Carolina); New York University (New York, New York); The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John O'Bryan (Charleston, South Carolina); Shohei Koide (New York, New York); Akiko Koide (New York, New York) |
| ABSTRACT | The invention provides compositions and methods for binding Ras in a nucleotide free state (apo RAS) and inhibiting Ras signaling. In one embodiment, the invention provides monobodies that specifically bind apo RAS and methods of use. Thus, in diseases and conditions where a reduction of Ras signaling is beneficial, such inhibitory compositions act as therapeutics. |
| FILED | Thursday, June 18, 2020 |
| APPL NO | 17/620395 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39558 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/32 (20130101) Original (OR) Class C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/569 (20130101) C07K 2319/30 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5748 (20130101) G01N 2333/914 (20130101) G01N 2500/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20220326190 | Bingham et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Boeing Company (Chicago, Illinois) |
| ASSIGNEE(S) | The Boeing Company (Chicago, Illinois) |
| INVENTOR(S) | Jill P. Bingham (Seattle, Washington); Barry A. Fetzer (Renton, Washington); Gary E. Georgeson (Tacoma, Washington); Samuel R. Goertz (Issaquah, Washington) |
| ABSTRACT | A system for inspecting a structure includes a laser ultrasound device configured to direct laser light onto a surface of the structure that generates ultrasonic waves within the structure and to generate an array of ultrasound data representative of the ultrasonic waves. The system includes a robotic arm configured to move the laser light across the surface. The system includes a multiplex controller configured to trigger generation of the ultrasonic waves within the structure at an inspection location and to receive the array of ultrasound data for the inspection location. The system includes a computer system that includes a motion-control module configured to control movement of the laser light relative to the surface of the structure, a motion-tracking module configured determine when the laser light is at the inspection location, and an inspection module configured to process the array of ultrasound data to inspect the structure at the inspection location. |
| FILED | Friday, January 14, 2022 |
| APPL NO | 17/575777 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/1605 (20130101) B25J 9/1664 (20130101) B25J 9/1692 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/04 (20130101) G01N 29/225 (20130101) G01N 29/265 (20130101) G01N 29/2418 (20130101) Original (OR) Class G01N 35/0099 (20130101) G01N 2291/103 (20130101) G01N 2291/0231 (20130101) G01N 2291/2694 (20130101) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 2219/40613 (20130101) G05B 2219/49007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220328274 | GUERRERO VELA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pedro P. GUERRERO VELA (Pasadena, California); James E. POLK (Pasadena, California) |
| ABSTRACT | Aspects include a method for treating a polycrystalline material, the method comprising: exposing a surface of the polycrystalline material to a plasma thereby changing the surface of the polycrystalline material from being characterized by a starting condition to being characterized by a treated condition; wherein: the surface comprises a plurality of crystallites each having the composition MB6, M being a metal element; the plasma comprises ions, the ions being characterized by an average ion flux selected from the range of 1.5 to 100 A/cm2 and an average ion energy that is less than a sputtering threshold energy; the starting condition of the surface is characterized by a first average work function and the treated condition of the surface is characterized by a second average work function; and the second average work function is less than the first average work function. |
| FILED | Friday, April 02, 2021 |
| APPL NO | 17/221170 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 41/009 (20130101) C04B 41/0054 (20130101) C04B 41/91 (20130101) C04B 2235/3804 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 1/025 (20130101) H01J 1/146 (20130101) Original (OR) Class H01J 9/042 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20220325332 | Balijepalli et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arvind Kumar Balijepalli (Washington, District of Columbia); Jacob Michael Majikes (Gaithersburg, Maryland); Alokik Kanwal (Gaithersburg, Maryland); Peter Michael Vallone (Potomac, Maryland); Kevin Michael Kiesler (Rockville, Maryland); Erica Lee Romsos (Ijamsville, Maryland); Anthony José Kearsley (Hanover, Maryland) |
| ABSTRACT | An agile nucleic acid sensor includes: a DNA switch; an analysis substrate in electrostatic communication with the DNA switch and that produces a biomarker electrical signal; a transduction member that receives the biomarker electrical signal and produces a transduction signal; a sensor counter electrode in electrical communication with and capacitively coupled to the analysis substrate and that receives a counter electrode voltage; a sensor reference electrode in electrical communication and capacitively coupled to the analysis substrate and that produces a feedback signal based on electrical interactions with a composition that is in fluid contact with the feedback signal and the analysis substrate; and a voltage follower in electrical communication with the sensor counter electrode and the sensor reference electrode and that receives the feedback signal from the sensor reference electrode and produces the counter electrode voltage for the sensor counter electrode based on the feedback signal. |
| FILED | Tuesday, June 21, 2022 |
| APPL NO | 17/845682 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6825 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20220323297 | Oaks et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Tristan Oaks (Arlington, Virginia); Wesley Russell (Dubois, Pennsylvania); Sadie Simons (Ware, Massachusetts); Breanna Wood (Somerset, Massachusetts); Michael Plumley (New London, Connecticut); Ronald Adrezin (East Lyme, Connecticut) |
| ABSTRACT | An improvement to portable cardiopulmonary resuscitation (CPR), includes a first module hub housing, an inflation actuated soft gripper configured to receive an inflation gas in response, to change form to a deployed grip state that accommodates and grips a human torso. Improvements include the inflatable gripper not requiring lifting the patient. Improvements also include modularity for in-the-field reconfigurability, in which a second module hub housing attaches to the first module hub housing, carrying a CPR pressure applicator configured to receive an actuator power and control signal causing, concurrent with the deployed grip state, cyclic extension and retraction of a pressure applicator along an axis aligned with a sternum of the human torso. |
| FILED | Tuesday, February 08, 2022 |
| APPL NO | 17/667325 |
| CURRENT CPC | Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 31/006 (20130101) Original (OR) Class A61H 2201/0103 (20130101) A61H 2201/0107 (20130101) A61H 2201/0157 (20130101) A61H 2201/1215 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Security Agency (NSA)
| US 20220329521 | Roweth et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hewlett Packard Enterprise Development LP (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Duncan Roweth (Bristol Avon, United Kingdom); Joseph G. Kopnick (Chippewa Falls, Wisconsin); Andrew S. Kopser (Seattle, Washington); Edwin L. Froese (Burnaby British Columbia, Canada) |
| ABSTRACT | Systems and methods are provided for performing routing in a switch network or fabric. Switches can be configured in a hierarchical topology having a plurality of groups, where switches in a group are connected to one another, and groups are connected to other groups. Routing can be performed by maintaining per-group group load information. A packet can be routed between at least two groups using the per-group group load information to effect a set of routing decisions. The set of routing decisions can be biased towards or away one or more paths. |
| FILED | Monday, March 23, 2020 |
| APPL NO | 17/594609 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 43/0876 (20130101) H04L 45/46 (20130101) H04L 45/70 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Office of the Director of National Intelligence (ODNI)
| US 20220326071 | Lal |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amit Lal (Ithaca, New York) |
| ABSTRACT | A device configured for low-energy ultrasonic 2D Fourier transform analysis, comprising: (i) a first layer comprising an array of piezoelectric pixels; (ii) a second layer comprising an array of piezoelectric pixels; (iii) a third layer, positioned between the first and second layers, comprising a bulk ultrasonic transmission medium; wherein the second layer of array of piezoelectric pixels is in the Fourier plane of an input signal of the first layer array of piezoelectric pixels. |
| FILED | Friday, April 15, 2022 |
| APPL NO | 17/721882 |
| CURRENT CPC | Measurement of Mechanical Vibrations or Ultrasonic, Sonic or Infrasonic Waves G01H 11/08 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/46 (20130101) G01N 2291/0426 (20130101) Electric Digital Data Processing G06F 17/142 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 41/18 (20130101) H01L 41/083 (20130101) Transmission H04B 11/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20220323562 | WU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Protein Potential, LLC (Rockville, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yun WU (Rockville, Maryland); Dennis J. KOPECKO (Silver Spring, Maryland); B. Kim Lee SIM (Gaithersburg, Maryland); Stephen L. HOFFMAN (Gaithersburg, Maryland) |
| ABSTRACT | Disclosed is the attenuated Salmonella typhi vaccine Ty21a utilized as a vector for Shigella and/or enterotoxogenic E. coli genes stably integrated in the Ty21a chromosome. These genes include a heterologous Shigella sonnei O-antigen biosynthetic gene region that comprises the wzz gene and expresses Shigella sonnei form 1 O-antigen, as well as a heterologous acid resistance biosynthetic gene system comprising a YbaS gene, which enables increased stability of the Ty21a vector at pH 2.5 relative to Ty21a without the integrated acid resistance biosynthetic gene system. |
| FILED | Monday, April 25, 2022 |
| APPL NO | 17/660558 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0275 (20130101) A61K 39/0283 (20130101) Original (OR) Class A61K 2039/522 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20220323493 | Poznansky et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark C. Poznansky (Newton, Massachusetts); Jeffrey A. Gelfand (Cambridge, Massachusetts) |
| ABSTRACT | This disclosure is directed to methods of preparing dendritic cells or other CD40 bearing antigen-presenting cells and methods of treating cancer by using the dendritic cells or other antigen-presenting cells in combination with anti-chemorepellant agents. This disclosure is further directed to methods of preparing T cells and methods of treating cancer, by activated T cells optionally in combination with anti-chemorepellant agents. The antigen presenting cells of the disclosure are activated by incubation with cancer cells and fusion proteins. The T cells of the disclosures are activated by incubation with activated antigen-presenting cells that were activated by incubation with cancer cells and a fusion protein. In particular, the fusion protein comprises an antigen-binding domain, e.g., an antibody or antibody fragment, and a stress protein domain. |
| FILED | Friday, June 17, 2022 |
| APPL NO | 17/843643 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/15 (20130101) Original (OR) Class A61K 39/001168 (20180801) A61K 45/06 (20130101) A61K 2039/892 (20180801) A61K 2039/6043 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/47 (20130101) C07K 16/3069 (20130101) C07K 2319/30 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0639 (20130101) C12N 2501/07 (20130101) C12N 2501/998 (20130101) C12N 2502/30 (20130101) C12N 2502/1121 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220324066 | ARGENTINE |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BWXT Nuclear Operations Group, Inc. (Lynchburg, Virginia) |
| ASSIGNEE(S) | BWXT Nuclear Operations Group, Inc. (Lynchburg, Virginia) |
| INVENTOR(S) | Frank A. ARGENTINE (Copley, Ohio) |
| ABSTRACT | Properties and performance of weld material between metals in a weldment is controlled by modifying one or more of the nitrogen content and the carbon content to produce carbide (e.g. MC-type), nitride and/or complex carbide/nitride (e.g. MX-type) type precipitates. Fusion welding includes (i) adjusting shield gas composition to increase nitrogen/carbon gas and nitride/carbide species, (ii) adjusting composition of nitrogen/carbon in materials that participate in molten welding processes, (iii) direct addition of nitrides/carbides (e.g. powder form), controlled addition of nitride/carbide forming elements (e.g. Ti, Al), or addition of elements that increase/impede solubility of nitrogen/carbon or nitride/carbide promoting elements (e.g. Mn), and (iv) other processes, such as use of fluxes and additive materials. Weld materials have improved resistance to different cracking mechanisms (e.g., hot cracking mechanisms and solid state cracking mechanisms) and improved tensile related mechanical properties. |
| FILED | Thursday, June 23, 2022 |
| APPL NO | 17/847715 |
| CURRENT CPC | Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 9/23 (20130101) B23K 9/167 (20130101) B23K 9/173 (20130101) B23K 9/0286 (20130101) B23K 35/304 (20130101) Original (OR) Class B23K 35/383 (20130101) B23K 2103/18 (20180801) Alloys C22C 19/055 (20130101) C22C 19/056 (20130101) C22C 19/058 (20130101) Devices for Fastening or Securing Constructional Elements or Machine Parts Together, e.g Nails, Bolts, Circlips, Clamps, Clips, Wedges, Joints or Jointing F16B 5/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220325633 | Davis et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | RAYTHEON TECHNOLOGIES CORPORATION (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Todd A. Davis (Tolland, Connecticut); Christopher M. Valva (Manchester, Connecticut) |
| ABSTRACT | A gas turbine engine includes a first bearing compartment and a seal assembly within the first bearing compartment that includes a rotatable seal seat, a gutter radially outward of the seal seat and fixed against rotation. The gutter includes a channel on its radially inner face. A second bearing compartment is also included. A scavenge pump is in communication with a first supply line configured to supply the first bearing compartment and a second supply line configured to supply the second bearing compartment. The gutter is in communication with the scavenge pump through a gutter scavenge line. |
| FILED | Tuesday, June 28, 2022 |
| APPL NO | 17/851412 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 25/20 (20130101) F01D 25/186 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2260/98 (20130101) Shafts; Flexible Shafts; Elements or Crankshaft Mechanisms; Rotary Bodies Other Than Gearing Elements; Bearings F16C 33/76 (20130101) F16C 33/6637 (20130101) F16C 2360/23 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220327659 | Moore et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jerry O. Moore (Wylie, Texas); Matthew A. Schaefer (Rowlett, Texas) |
| ABSTRACT | A system mitigates transitions among pixels a mosaic image. The system uses two balancing adjustments and an easing transition adjustment. The first balancing adjustment uses a histogram to remap the pixels in the mosaic to a normal distribution. The second balancing adjustment minimizes transitions between adjacent individual images in the mosaic based on pixels positions of edge pixels and intensity differences between edge pixels in the adjacent images. The easing transitions adjustment modifies the intensity of a target pixel as a function of a radius from the target pixel, the distance between the target pixel and a nearest neighbor pixel, and an intensity difference between the nearest neighbor pixel and a pixel adjacent to the nearest neighbor pixel. A revised mosaic image is created as a function of the first balancing adjustment, the second balancing adjustment, and the easing transition adjustment. |
| FILED | Thursday, April 08, 2021 |
| APPL NO | 17/225566 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 3/4038 (20130101) Original (OR) Class G06T 5/40 (20130101) G06T 7/70 (20170101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, October 13, 2022.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20221013.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page