FedInvent™ Patent Applications
Application Details for Thursday, October 27, 2022
This page was updated on Friday, October 28, 2022 at 04:04 PM GMT
Department of Health and Human Services (HHS)
| US 20220338465 | Kamm et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Roger Kamm (Cambridge, Massachusetts); Zhengpeng Wan (Cambridge, Massachusetts); Shun Zhang (Cambridge, Massachusetts) |
| ABSTRACT | Microfluidic platforms for forming and culturing perfusable hydrogel vascularized tissues typically include one or more culture chambers. Each culture chamber includes at least two openings overlaid over a gel channel. The gel channel typically includes at least two tissue zones and a trapping or insertion portion positioned between the tissue zones. The trapping or insertion portion permits vascular networks to develop between the two tissue zones containing vascularized tissues and/or vascularized tissue masses. The vascularized tissue masses in the tissue zones of the gel channel are connected indirectly, via the vascular network of the trapping portion. Also described are methods of forming and culturing perfusable vascularized tissue masses directly or indirectly interconnected via vascularized networks. |
| FILED | Monday, April 25, 2022 |
| APPL NO | 17/728642 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/021 (20130101) A01N 1/0247 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220338722 | Eden et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the University of lllinois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | J. Gary Eden (Urbana, Illinois); Peter P. Sun (Urbana, Illinois); Wenyuan Chen (Urbana, Illinois); Thanh H. Nguyen (Urbana, Illinois); Guillermo L. Monroy (Urbana, Illinois); Jungeun Won (Urbana, Illinois); Stephen A. Boppart (Urbana, Illinois) |
| ABSTRACT | A speculum body is configured to attach to the otoscope. An array of radially situated microchannels is within the speculum body and extends to apertures in a distal end of the speculum body. A power electrode array is within the speculum body positioned with respect to the microchannels to excite plasma generation within the microchannels. An optically transparent central portion is in the body to permit viewing of an eardrum by a practitioner. A method of treatment of the middle ear and/or middle ear cavity incudes actuating plasma jets to extend into the ear canal from a speculum attached to the otoscope and continuing the plasma jet treatment for a period of time sufficient to inactivate or kill a bacterial biofilm in the middle ear and/or the middle ear cavity. |
| FILED | Wednesday, June 24, 2020 |
| APPL NO | 17/621803 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/227 (20130101) Original (OR) Class Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/44 (20130101) Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 1/2431 (20210501) H05H 2245/30 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220338750 | ALLEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (Charlottesville, Virginia); VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (Blacksburg, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven P. ALLEN (Charlottesville, Virginia); Craig H. Meyer (Charlottesville, Virginia); Eli VLAISAVLJEVICH (Blacksburg, Virginia); Richey M. DAVIS (Blacksburg, Virginia); Austin D. FERGUSSON (Blacksburg, Virginia); Connor W. EDSALL (Blacksburg, Virginia) |
| ABSTRACT | Disclosed herein are devices, systems, and methods for use in a magnetic resonance imaging (MRI)-guided procedure in which focused energy is applied to an area of interest of a subject. Disclosed herein are coupling baths comprising an aqueous solution comprising a plurality of paramagnetic particles dispersed in water, wherein, when magnetic resonance images are collected from the area of interest of the subject for MRI guidance: the coupling bath is located proximate to the area of interest, and the composition, the average particle size, the shape, the concentration, the presence or absence of the capping layer, the identity of the plurality of ligands when the capping layer is present, the average thickness of the capping layer when the capping layer is present, or a combination thereof is/are selected such that the coupling bath reduces or prevents imaging artifacts in the magnetic resonance images for the MRI guidance. |
| FILED | Saturday, September 19, 2020 |
| APPL NO | 17/642298 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) Original (OR) Class A61B 90/37 (20160201) A61B 2090/374 (20160201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220338786 | Borton et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BROWN UNIVERSITY (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David A. Borton (Pawtucket, Rhode Island); Evan M. Dastin-van Rijn (Silver Spring, Maryland); Matthew T. Harrison (Providence, Rhode Island); Nicole R. Provenza (Providence, Rhode Island); Paula Chen (Storrs, Connecticut); Taewoo Kim (Providence, Rhode Island); Jerome Darbon (Providence, Rhode Island) |
| ABSTRACT | Methods and systems for improved removal of deep brain stimulation artifacts from electrical measurements of brain activity. In one embodiment, a method is provided that includes: receiving, by a computing device having a processor, waveform data caused by a deep brain stimulation of a patient-specific area of interest; determining, by the computing device, a stimulation period relative to a sampling rate; identifying, by the computing device and based on the waveform data and the stimulation period, a stimulation artifact; subtracting, by the computing device, the identified stimulation artifact from the received waveform data; and generating, in real-time, a filtered waveform data indicating an absence of the stimulation artifact. |
| FILED | Monday, April 18, 2022 |
| APPL NO | 17/722903 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/37 (20210101) Original (OR) Class A61B 5/372 (20210101) A61B 5/725 (20130101) A61B 5/7203 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220338819 | STAYMAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Joseph Webster STAYMAN (Baltimore, Maryland); Jianan GANG (Baltimore, Maryland) |
| ABSTRACT | In some implementations, a device may obtain scan information associated with scanning a section of a body that includes an object within tissue of the section. The device may determine a region of the section that is likely to be represented by an artifact in an image obtained using a first scanning type of a medical image device. The device may determine a plurality of scan patterns for scanning the region using a second scanning type. The device may determine, for the plurality of scan patterns, individual scan scores associated with scanning the region. The device may select, based on the individual scan scores, an optimal scan pattern from the plurality of scan patterns. The device may transmit the optimal scan pattern to the medical imaging device to permit the medical imaging device to scan the section to obtain optimized image data associated with the region. |
| FILED | Friday, September 25, 2020 |
| APPL NO | 17/753726 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/032 (20130101) Original (OR) Class A61B 6/54 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220338828 | Slomka et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CEDARS-SINAI MEDICAL CENTER (Los Angeles, California) |
| ASSIGNEE(S) | CEDARS-SINAI MEDICAL CENTER (Los Angeles, California) |
| INVENTOR(S) | Piotr Slomka (Los Angeles, California); Sebastien Cadet (Los Angeles, California); Paul Kavanagh (Santa Monica, California); Tejas Parekh (San Gabriel, California) |
| ABSTRACT | Assessment of transthyretin amyloid cardiomyopathy (ATTR-CM) can be performed by calculating a cardiac pyrophosphate activity (CPA) measurement from single-photon emission computed tomography (SPECT) images. SPECT images obtained using 99mTechnetium-pyrophosphate as a radiotracer can be analyzed to calculate CPA. Scan-specific thresholds for abnormal myocardial activity are identified based on left ventricular blood pool (LVBP) radiotracer counts, then radiotracer activity in regions of the myocardium with abnormal myocardial activity is determined. Finally, a CPA measurement can be calculated as a function of the mean radiotracer counts in such regions over the maximal LVBP radiotracer activity multiplied by the volume of involvement (e.g., the volume of abnormal activity). This CPA measurement can then be used as an assessment of ATTR-CM. |
| FILED | Thursday, April 14, 2022 |
| APPL NO | 17/720764 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/032 (20130101) A61B 6/037 (20130101) A61B 6/469 (20130101) A61B 6/503 (20130101) Original (OR) Class A61B 6/5235 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220339116 | Raimondi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Giorgio Raimondi (Severna Park, Maryland); Julia Patrone (Ellicott City, Maryland); Xiomara Calderon-Colon (Fulton, Maryland); Olivia Tiburzi (Silver Spring, Maryland) |
| ABSTRACT | Lipid nanoparticle compositions for use in immunomodulation and treatment of autoimmune and related diseases such as Type 1 Diabetes are provided along with methods for using same. |
| FILED | Friday, April 03, 2020 |
| APPL NO | 17/600843 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5123 (20130101) Original (OR) Class A61K 31/519 (20130101) A61K 31/541 (20130101) A61K 38/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220339121 | SHULMAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gerald I. SHULMAN (East Haven, Connecticut); Rachel Jamison PERRY (New Haven, Connecticut) |
| ABSTRACT | The present invention includes a low dose and sustained release formulation of a mitochondrial uncoupling agent The compositions of the invention are useful for preventing or treating a disease or disorder, such as non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, insulin resistance and/or diabetes, in a subject in need thereof. |
| FILED | Monday, May 16, 2022 |
| APPL NO | 17/663586 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 9/501 (20130101) A61K 9/5026 (20130101) A61K 9/5042 (20130101) A61K 9/5047 (20130101) A61K 31/06 (20130101) Original (OR) Class A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220339127 | Bharti et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Kapil Bharti (Bethesda, Maryland); Karla Yadira Barbosa Sabanero (Bethesda, Maryland); Justin Ren Yuan Chang (Bethesda, Maryland); Balendu Shekhar Jha (Bethesda, Maryland); Ruchi Sharma (Bethesda, Maryland) |
| ABSTRACT | This invention relates to novel method of treating or ameliorating a retinal disease or disorder or retinal degradation in a subject and a novel method of restoring retinal pigment epithelium cell compromising the administration of a one or more compounds which modulate Nox4, formation of radical oxygen species, serine protease, a dopamine receptor, NF-kB, mTOR, AMPK, RPE epithelial to mesenchymal transition, RPE dedifferentiation, or one or more Rho GTPases; and kits for administration of the methods. |
| FILED | Friday, September 11, 2020 |
| APPL NO | 17/642610 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 31/155 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220339134 | BAZAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ricardo Palacios PELAEZ (Madrid, Spain); Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicolas G. BAZAN (New Orleans, Louisiana); Ricardo Palacios PELAEZ (Madrid, Spain) |
| ABSTRACT | This disclosure relates to methods of use related to omega-3 very-long-chain polyunsaturated fatty acids (n-3 VLC-PUFA) and their hydroxylated derivatives known as elovanoids to alleviate a symptom of, treat, or prevent disease. Furthermore, this invention is directed to compositions and methods for modulating VLC-PUFA bioactivity and availability. |
| FILED | Friday, September 04, 2020 |
| APPL NO | 17/639757 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/202 (20130101) Original (OR) Class A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220339154 | KARP et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (CAMBRIDGE, Massachusetts); THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (BOSTON, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey M. KARP (Brookline, Massachusetts); Robert S. LANGER (Newton, Massachusetts); Xiaolei YIN (Quincy, Massachusetts); Nitin JOSHI (Boston, Massachusetts) |
| ABSTRACT | Method and compositions for inducing the self-renewal of stem/progenitor supporting cells comprised by a cochlear cell population, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells. |
| FILED | Monday, June 27, 2022 |
| APPL NO | 17/809060 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0046 (20130101) A61K 31/19 (20130101) A61K 31/55 (20130101) A61K 31/167 (20130101) A61K 31/422 (20130101) A61K 31/437 (20130101) A61K 31/506 (20130101) Original (OR) Class A61K 31/4709 (20130101) A61K 31/5377 (20130101) A61K 31/5517 (20130101) A61K 33/00 (20130101) A61K 35/36 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/062 (20130101) C12N 5/0627 (20130101) C12N 2501/11 (20130101) C12N 2501/42 (20130101) C12N 2501/105 (20130101) C12N 2501/115 (20130101) C12N 2501/415 (20130101) C12N 2501/727 (20130101) C12N 2501/999 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220339155 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | City of Hope (Duarte, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jianjun Chen (Temple City, California); Xiaolan Deng (Temple City, California); Li Han (Monrovia, California); Hongzhi Li (Diamond Bar, California); Rui Su (Monrovia, California) |
| ABSTRACT | The disclosure provides, inter alia, METTL16 inhibitors and methods of treating cancers that overexpress METTL16. |
| FILED | Thursday, August 20, 2020 |
| APPL NO | 17/632963 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220339184 | Tavazoie et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Rockefeller University (New York, New York) |
| ASSIGNEE(S) | The Rockefeller University (New York, New York) |
| INVENTOR(S) | Sohail Tavazoie (New York, New York); Norihiro Yamaguchi (New York, New York); Kivanc Birsoy (New York, New York) |
| ABSTRACT | The present invention relates to agents and methods for treating gastrointestinal cancer (e.g., metastatic colorectal cancer) in a subject in need thereof. The method includes suppressing the enzymatic activity of DHODH and/or decreasing the level of creatine via suppression of creatine transporter channel SLC6a8 in the subject. In some embodiments, the suppression step can be carried out by administering to the subject a set of small molecule compounds. |
| FILED | Friday, September 25, 2020 |
| APPL NO | 17/762529 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7105 (20130101) Original (OR) Class A61K 38/005 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220339191 | Egwuagu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Charles E. Egwuagu (Silver Spring, Maryland); Jin Kyeong Choi (Busan, South Korea) |
| ABSTRACT | The invention is directed to an isolated population of mammal cells comprising about 75% or higher B-1a regula e PBS-treated tory cells expressing the cell surface inhibitory receptors lympho-cyte-activation gene 3 (LAG-3), programmed cell death protein 1 (PD-1), and C-X-C chemokine receptor type 4 (CXCR4), and secreting interleukin-27 (IL-27). The invention is also directed to methods of preparing and using the cell population to suppress the immune system and/or to treat or prevent diseases. |
| FILED | Thursday, June 18, 2020 |
| APPL NO | 17/620248 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 38/20 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0635 (20130101) C12N 2501/998 (20130101) C12N 2501/2327 (20130101) C12N 2502/1121 (20130101) C12N 2502/1157 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220339195 | Kealey |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Monarch Biosciences, Inc. (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Colin Patrick Kealey (Los Angeles, California) |
| ABSTRACT | Implantable scaffolds that treat solid tumors and escape variants and that provide effective vaccinations against cancer recurrence are described. The scaffolds include genetically-reprogrammed lymphocytes and a lymphocyte-activating moiety. |
| FILED | Wednesday, June 22, 2022 |
| APPL NO | 17/846391 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/70 (20130101) A61K 35/17 (20130101) Original (OR) Class A61K 38/177 (20130101) A61K 38/1774 (20130101) A61K 38/2086 (20130101) A61K 39/0011 (20130101) A61K 45/06 (20130101) A61K 47/34 (20130101) A61K 2039/54 (20130101) A61K 2039/575 (20130101) A61K 2039/5158 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 31/005 (20130101) A61L 31/06 (20130101) A61L 31/16 (20130101) A61L 31/042 (20130101) A61L 31/046 (20130101) A61L 31/146 (20130101) A61L 2300/416 (20130101) A61L 2300/606 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 35/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0638 (20130101) C12N 2501/06 (20130101) C12N 2501/998 (20130101) C12N 2501/999 (20130101) C12N 2510/00 (20130101) C12N 2533/00 (20130101) C12N 2533/74 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220339203 | SADOWSKY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| INVENTOR(S) | Michael J. SADOWSKY (Roseville, Minnesota); Alexander Khoruts (Golden Valley, Minnesota); Alexa R. Weingarden (St. Paul, Minnesota); Matthew J. Hamilton (Burnsville, Minnesota) |
| ABSTRACT | The present invention provides compositions that include an extract of human feces, and methods for using such compositions, including methods for replacing or supplementing or modifying a subject's colon microbiota, and methods for treating a disease, pathological condition, and/or iatrogenic condition of the colon. |
| FILED | Tuesday, June 28, 2022 |
| APPL NO | 17/852314 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/16 (20130101) A61K 9/0053 (20130101) A61K 9/1617 (20130101) A61K 9/1623 (20130101) A61K 35/24 (20130101) A61K 35/37 (20130101) Original (OR) Class A61K 35/74 (20130101) A61K 35/741 (20130101) A61K 35/742 (20130101) A61K 45/06 (20130101) A61K 47/08 (20130101) A61K 47/26 (20130101) A61K 2035/11 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220339221 | DENG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MEMORIAL SLOAN KETTERING CANCER CENTER (New York, New York) |
| ASSIGNEE(S) | MEMORIAL SLOAN KETTERING CANCER CENTER (New York, New York) |
| INVENTOR(S) | Liang DENG (New York, New York); Stewart SHUMAN (New York, New York); Jedd WOLCHOK (New York, New York); Taha MERGHOUB (New York, New York); Weiyi WANG (New York, New York); Peihong DAI (New York, New York); Ning Yang (New York, New York) |
| ABSTRACT | The present invention relates generally to the fields of oncology, virology and immunotherapy. More particularly, it concerns the use of poxviruses, specifically the replication competent attenuated vaccinia virus with deletion of thymidine kinase (VC-TK−) with and without the expression of human Flt3L or GM-CSF as oncolytic and immunotherapy. The foregoing poxviruses can also be used in combination with immune checkpoint blocking agents. The foregoing poxviruses can also be inactivated via Heat or UV-treatment and the inactivated virus can be used as immunotherapy either alone or in combination with immune checkpoint blocking agents. |
| FILED | Friday, August 07, 2020 |
| APPL NO | 16/988137 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/76 (20130101) A61K 35/768 (20130101) Original (OR) Class A61K 39/3955 (20130101) A61K 48/00 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/521 (20130101) C07K 14/535 (20130101) C07K 16/2818 (20130101) C07K 16/2827 (20130101) C07K 2317/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2710/24143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220339223 | Gromeier et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthias Gromeier (Durham, North Carolina); John H. Sampson (Durham, North Carolina); Darell D. Bigner (Mebane, North Carolina); Annick Desjardins (Durham, North Carolina); Henry S. Friedman (Durham, North Carolina) |
| ABSTRACT | Human clinical use of a chimeric poliovirus construct has demonstrated excellent anti-tumor effect. The mechanism of action is believed to involve both viral oncolysis as well as immune recruitment, both of which lead to necrosis in the area of the tumor. No adverse effects have been observed. |
| FILED | Tuesday, July 05, 2022 |
| APPL NO | 17/857534 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0085 (20130101) A61K 35/768 (20130101) Original (OR) Class A61K 41/00 (20130101) A61K 45/06 (20130101) A61K 51/081 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/10 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2770/32611 (20130101) C12N 2770/32632 (20130101) C12N 2770/32671 (20130101) C12N 2770/32733 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220339243 | DINUBILE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BioAegis Therapeutics Inc. (Morristown, New Jersey); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | BioAegis Therapeutics Inc. (Morristown, New Jersey); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Mark J. DINUBILE (Morristown, New Jersey); Susan L. LEVINSON (Morristown, New Jersey); Thomas P. STOSSEL (Morristown, New Jersey); Lester KOBZIK (San Carlos, California) |
| ABSTRACT | The present invention relates to compositions and methods for treating microbial infections in subjects, in particular methods of administering a gelsolin agent and an antimicrobial agent to produce a synergistic therapeutic effect against a microbial infection in a subject. The present invention also relates to methods for treating viral infections in subjects, including methods that include delayed-dosing methods and/or synergistic methods. |
| FILED | Sunday, June 21, 2020 |
| APPL NO | 17/620871 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) Original (OR) Class A61K 45/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) A61P 31/12 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220339244 | Portman |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Seattle Children's Hospital (d/b/a Seattle Children's Research Institute) (Seattle, Washington) |
| ASSIGNEE(S) | Seattle Children's Hospital (d/b/a Seattle Children's Research Institute) (Seattle, Washington) |
| INVENTOR(S) | Michael A. Portman (Seattle, Washington) |
| ABSTRACT | The present invention relates to the discovery that etanercept reduces the rate of resistance to intravenous gamma globulin (IVIG) in subjects with acute Kawasaki disease (KD). In certain embodiments, the co-administration of etanercept and IVIG more effectively treats acute KD in subjects older than 12 months than IVIG alone. In other embodiments, the co-administration of etanercept and IVIG ameliorates coronary artery dilation in high risk subjects. |
| FILED | Tuesday, January 18, 2022 |
| APPL NO | 17/648242 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/05 (20130101) A61K 31/25 (20130101) A61K 31/047 (20130101) A61K 31/60 (20130101) A61K 31/192 (20130101) A61K 31/717 (20130101) A61K 31/718 (20130101) A61K 31/7016 (20130101) A61K 38/1709 (20130101) Original (OR) Class A61K 39/395 (20130101) A61K 39/3955 (20130101) A61K 39/39516 (20130101) A61K 47/02 (20130101) A61K 47/12 (20130101) A61K 47/36 (20130101) A61K 47/183 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/00 (20180101) Peptides C07K 16/06 (20130101) C07K 16/241 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220339246 | ZANGI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lior ZANGI (New York, New York); Keerat KAUR (New York, New York) |
| ABSTRACT | The present disclosure relates to compositions including molecules of modified mRNA encoding GATA Binding Protein 4, modRNA encoding Myocyte Enhancer Factor 2C, modRNA encoding T-box 5, modRNA encoding Heart- and neural crest derivatives-expressed protein 2, modRNA encoding dominant negative transforming growth factor beta, and modRNA encoding domimant negative Wingless-related integration site 8a, wherein said molecules of modRNAs are present in said composition in a ratio. The present disclosure further relates to pharmaceutical compositions, methods for increasing a ratio of a number of cardiomyocytes to a number of non-cardiomyocytes within a population of cells, methods for treating cardiac injury, methods for stimulating vascular regeneration, methods for treating of stroke, and methods for enhancing wound healing. |
| FILED | Friday, September 11, 2020 |
| APPL NO | 17/753660 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) Original (OR) Class A61K 48/005 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/04 (20180101) A61P 9/10 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0657 (20130101) C12N 2501/998 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220339257 | Bertenshaw et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Biomarker Strategies, LLC (Rockville, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Greg P. Bertenshaw (Rockville, Maryland); Meena Chandok (Rockville, Maryland); William Murphy (Rockville, Maryland); Gregory Botting (Rockville, Maryland); Palak Parekh (Rockville, Maryland); Senthamil Selvan (Rockville, Maryland) |
| ABSTRACT | This invention relates to methods of increasing the sensitivity of tumors to anti cancer therapies including antibody therapy, chemotherapy, radiotherapy, and therapies targeting cell signaling pathways such as the MAPK and PI3K pathways and receptor tyrosine kinases (e.g. EGFR). By increasing sensitivity of tumors to these agents, this invention will: (a)Prolong response in already responsive subjects; (b) Increase response rates by converting non-responsive patients into responsive patients; (c) Reverse treatment-induced resistance of tumors to anticancer therapy; and (d) Decrease treatment-associated toxicities by decreasing therapy dosages required for response. The invention also describes predictive tests, to identify patients most likely to respond to the combination treatments. |
| FILED | Thursday, September 17, 2020 |
| APPL NO | 17/761461 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/517 (20130101) A61K 38/191 (20130101) A61K 38/204 (20130101) A61K 38/217 (20130101) Original (OR) Class A61K 38/1841 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220339265 | Ozdinler et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | P. Hande Ozdinler (Chicago, Illinois); Javier H. Jara (Chicago, Illinois); Baris Genc (Evanston, Illinois) |
| ABSTRACT | Disclosed are compositions and methods for treating neurological diseases, disorders, and injuries in a subject in need thereof. Particularly disclosed are compositions and methods for treating neurological diseases, disorders, and injuries that are associated with upper motor neurons in a subject in need thereof in which methods expression of ubiquitin carboxyl hydrolase ligase 1 (UCHL1) is modulated in the subject, for example, via gene therapy being administered to the subject in order to express UCHL1 in upper motor neurons of the subject. Also disclosed are expression vectors comprising the UCHL1 promoter operably linked to a nucleic acid encoding a therapeutic gene product. |
| FILED | Monday, June 13, 2022 |
| APPL NO | 17/838428 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/47 (20130101) Original (OR) Class A61K 48/0008 (20130101) A61K 48/0066 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220339266 | WAGNER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| INVENTOR(S) | Denisa D. WAGNER (Dover, Massachusetts); Siu Ling WONG (Singapore, Singapore) |
| ABSTRACT | The disclosure provides a method for treating and/or preventing graft rejection with A Disintegrin And Metalloproteinase with Thrombospondin type 1 motif, member-13 (ADAMTS13). The disclosure provides a method for increasing ADAMTS13-mediated von Willebrand factor (VWF) cleavage in a subject that received a graft by administering ADAMTS13. The disclosure also provides a method of determining the likelihood that a subject will rejection a graft. |
| FILED | Friday, October 02, 2020 |
| APPL NO | 17/765728 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/4886 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/06 (20180101) Enzymes C12Y 304/24082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220339274 | Najibi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Alexander J. Najibi (Cambridge, Massachusetts); Nisarg J. Shah (San Diego, Massachusetts); Hua Wang (Cambridge, Massachusetts); David J. Mooney (Sudbury, Massachusetts); David T. Scadden (Weston, Massachusetts) |
| ABSTRACT | Disclosed herein are vaccine compostions and method to use the same. The compositions and methods disclosed herein provide means to prevent and/or treat a variety of cancers. |
| FILED | Tuesday, March 22, 2022 |
| APPL NO | 17/701270 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7034 (20130101) A61K 39/001153 (20180801) Original (OR) Class A61K 2039/5154 (20130101) A61K 2039/55561 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220339278 | Boyington et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Jeffrey C. Boyington (Clarksburg, Maryland); Barney S. Graham (Smyrna, Georgia); John R. Mascola (Rockville, Maryland); Hadi M. Yassine (Doha, Qatar); Kizzmekia S. Corbett (Wheaton, Maryland); Syed M. Moin (Laurel, Maryland); Lingshu Wang (North Potomac, Maryland); Masaru Kanekiyo (Chevy Chase, Maryland) |
| ABSTRACT | Vaccines that elicit broadly protective anti-influenza antibodies. The vaccines comprise nanoparticles that display HA trimers from Group 2 influenza virus on their surface. The nanoparticles are fusion proteins comprising a monomeric subunit (e.g., ferritin) joined to stabilized stem regions of Group 2 influenza virus HA proteins. The fusion proteins self-assemble to form the HA-displaying nanoparticles. Also provided are fusion proteins, and nucleic acid molecules encoding such proteins, and assays using nanoparticles of the invention to detect anti-influenza antibodies. |
| FILED | Wednesday, May 11, 2022 |
| APPL NO | 17/742201 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/145 (20130101) Original (OR) Class A61K 2039/55555 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) Peptides C07K 14/005 (20130101) C07K 14/195 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220339283 | MEREDITH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Timothy MEREDITH (University Park, Pennsylvania); Gloria KOMAZIN (University Park, Pennsylvania); Michael A. MAYBIN (State College, Pennsylvania) |
| ABSTRACT | The present disclosure provides compositions and methods for enhancing immune response in a subject. In an embodiment, this disclosure provides modified LPS molecules and compositions comprising the modified LPS molecules. The disclosure also provides methods for enhancing an immune response in a subject. |
| FILED | Thursday, September 10, 2020 |
| APPL NO | 17/641760 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) Original (OR) Class A61K 2039/55572 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 13/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220339293 | Santa Maria et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter Luke Santa Maria (Redwood City, California); Laurent Bekale (Redwood City, California) |
| ABSTRACT | Compositions, methods, and kits are provided for treating bacterial infections with nanoparticles comprising a thiol-binding metallic core conjugated to a fluoroquinolone antibiotic. Recalcitrant infections are often difficult to treat because of the presence of persister cells, a subpopulation of bacterial cells that is highly tolerant of traditional antibiotics. Persister cells are dormant, which makes them less susceptible to many antibiotics, which are designed to kill growing cells. Administration of nanoparticles comprising a thiol-binding metallic core conjugated to fluoroquinolone antibiotics was found to be highly efficacious in eradicating persister cells and for treating infections for a broad range of bacterial species, including Gram-positive and Gram-negative bacteria. Such treatment was effective not only in eradicating planktonic bacteria but also bacteria in biofilms. |
| FILED | Wednesday, April 13, 2022 |
| APPL NO | 17/719727 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/60 (20170801) A61K 47/6929 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220339294 | Mandl et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hanna Mandl (New Haven, Connecticut); Elias Quijano (New Haven, Connecticut); W. Mark Saltzman (New Haven, Connecticut); Peter Glazer (New Haven, Connecticut) |
| ABSTRACT | Compositions containing populations of nanoparticles that show selective uptake by tissues and other cell types such as lung cells and/or bone marrow cells are described. The nanoparticles show this uptake by virtue of their size and in the absence of a targeting agent on the surface of the nanoparticles, i.e., passive targeting. The population of nanoparticles contain poly(lactic acid-co-glycolic acid), have a diameter between about 70 nm and about 220 nm, and at least 90% of the nanoparticles have a diameter between about 110 nm and about 129 nm. The nanoparticles are manufactured using a microfluidic system. The compositions can be used to treat lung- and/or blood-related genetic disorders in in vivo gene editing technologies. |
| FILED | Wednesday, September 09, 2020 |
| APPL NO | 17/641516 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/5153 (20130101) A61K 47/6937 (20170801) Original (OR) Class Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220339391 | Gillerman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Third Pole, Inc. (Waltham, Massachusetts) |
| ASSIGNEE(S) | Third Pole, Inc. (Waltham, Massachusetts) |
| INVENTOR(S) | Ian J. Gillerman (Somerville, Massachusetts); Gregory W. Hall (Belmont, Massachusetts); Wolfgang Scholz (Beverly, Massachusetts); David G. Zapol (San Francisco, California) |
| ABSTRACT | Systems and methods for nitric oxide generation are provided. In an embodiment, an NO generation system can include a controller and disposable cartridge that can provide nitric oxide to two different treatments simultaneously. The disposable cartridge has multiple purposes including preparing incoming gases for exposure to the NO generation process, scrubbing exhaust gases for unwanted materials, characterizing the patient inspiratory flow, and removing moisture from sample gases collected. Plasma generation can be done within the cartridge or within the controller. The system has the capability of calibrating NO and NO2 gas analysis sensors without the use of a calibration gas. |
| FILED | Thursday, June 30, 2022 |
| APPL NO | 17/855592 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 33/00 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 16/04 (20130101) A61M 16/12 (20130101) Original (OR) Class A61M 16/022 (20170801) A61M 16/024 (20170801) A61M 16/0057 (20130101) A61M 16/0093 (20140204) A61M 16/101 (20140204) A61M 16/107 (20140204) A61M 16/202 (20140204) A61M 16/0666 (20130101) A61M 2202/0275 (20130101) A61M 2202/0283 (20130101) A61M 2205/05 (20130101) A61M 2205/054 (20130101) A61M 2205/80 (20130101) A61M 2205/125 (20130101) A61M 2205/502 (20130101) A61M 2205/3584 (20130101) A61M 2205/8206 (20130101) A61M 2209/088 (20130101) Non-metallic Elements; Compounds Thereof; C01B 21/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220339601 | Reynolds et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Colorado State University Research Foundation (Fort Collins, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Melissa Reynolds (Fort Collins, Colorado); Jamie Cuchiaro (Fort Collins, Colorado); Nickolas Schaffner (Oskalooska, Iowa); Jon Thai (Fort Collins, Colorado) |
| ABSTRACT | Provided herein is a method for removing uremic toxins from blood is provided. The method includes exposing blood to iron-based metal-organic frameworks; and allowing the metal-organic frameworks to bind a least one uremic toxin in the blood. |
| FILED | Tuesday, April 26, 2022 |
| APPL NO | 17/729940 |
| CURRENT CPC | Separation B01D 15/00 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/226 (20130101) Original (OR) Class B01J 2220/46 (20130101) B01J 2531/842 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/0893 (20130101) G01N 2015/0866 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340516 | Malkas et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | City of Hope (Duarte, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Linda H. Malkas (Duarte, California); David Horne (Altadena, California); Robert J. Hickey (Duarte, California); Long Gu (Duarte, California) |
| ABSTRACT | Described herein, inter alia, are compositions of PCNA modulators and methods for treating or preventing cancer. |
| FILED | Wednesday, April 27, 2022 |
| APPL NO | 17/730948 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/167 (20130101) A61K 31/4409 (20130101) A61K 31/4418 (20130101) A61K 31/4725 (20130101) A61K 33/243 (20190101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 35/02 (20180101) Acyclic or Carbocyclic Compounds C07C 233/76 (20130101) Original (OR) Class C07C 237/22 (20130101) Heterocyclic Compounds C07D 213/68 (20130101) C07D 217/26 (20130101) C07D 401/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340526 | Khan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Clark Atlanta University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shafiq A. Khan (Mableton, Georgia); Silvia Caggia (Decatur, Georgia); Adegboyega K. Oyelere (Marietta, Georgia); Subhasish Tapadar (Atlanta, Georgia) |
| ABSTRACT | The disclosure relates to novel compounds and methods of use of the compounds to maintain the Gαi2 protein in its inactive GDP-bound state. The disclosure describes the knockdown or inhibition of Gαi2 negatively regulated migration of breast and ovarian cancer cell lines. The novel compounds inhibit the migratory behavior of PC3, DU145 and E006AA prostate cancer cell lines. Specifically, the novel compounds block the activation of Gαi2 in oxytocin-stimulated prostate cancer PC3 cells and inhibits the migratory capability of DU145 cells overexpressing constitutively active form of Gαi2, under basal and EGF-stimulated conditions. |
| FILED | Monday, December 20, 2021 |
| APPL NO | 17/556820 |
| CURRENT CPC | Heterocyclic Compounds C07D 209/08 (20130101) C07D 209/36 (20130101) Original (OR) Class C07D 333/54 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340531 | SAFO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VIRGINIA COMMONWEALTH UNIVERSITY (Richmond, Virginia); THE CHILDREN'S HOSPITAL OF PHILADELPHIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin K. SAFO (Richmond, Virginia); Yan ZHANG (Glen Allen, Virginia); Piyusha Pradeep PAGARE (Richmond, Virginia); Guoyan XU (Henrico, Virginia); Mohini GHATGE (Glen Allen, Virginia); Jurgen VENITZ (Richmond, Virginia); Osheiza ABDULMALIK (Wynnewood, Pennsylvania) |
| ABSTRACT | Compounds and methods for preventing and/or treating one or more symptoms of sickle cell diseases (SCD) by administering at least one of the compounds are provided. The compounds are based on vanillin which is chemically modified to increase bioavailability and activity, e.g. so that the compounds bind to the F helix of hemoglobin (Hb) and prevent adhesion of red blood cells (RBCs). |
| FILED | Wednesday, June 22, 2022 |
| APPL NO | 17/846101 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/00 (20180101) Heterocyclic Compounds C07D 213/79 (20130101) C07D 213/80 (20130101) Original (OR) Class C07D 401/04 (20130101) C07D 409/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340533 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Gardner Steel Conference Center (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Beibei Chen (Sewickley, Pennsylvania); Toren Finkel (Pittsburgh, Pennsylvania); Yuan Liu (Sewickley, Pennsylvania) |
| ABSTRACT | This document provides methods and materials for increasing the level of phosphorylated AMPK. For example, compounds (e.g., organic compounds) having the ability to increase the level of phosphorylated AMPK within cells, formulations containing compounds having the ability to increase the level of phosphorylated AMPK within cells, methods for making compounds having the ability to increase the level of phosphorylated AMPK within cells, methods for making formulations containing compounds having the ability to increase the level of phosphorylated AMPK within cells, methods for increasing the level of phosphorylated AMPK within cells, and methods for treating mammals (e.g., humans) having a condition responsive to an increase in the level of phosphorylated AMPK are provided. |
| FILED | Wednesday, September 09, 2020 |
| APPL NO | 17/641606 |
| CURRENT CPC | General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/05 (20130101) Acyclic or Carbocyclic Compounds C07C 217/20 (20130101) C07C 225/10 (20130101) Heterocyclic Compounds C07D 209/08 (20130101) C07D 211/76 (20130101) C07D 213/38 (20130101) C07D 213/71 (20130101) C07D 213/82 (20130101) C07D 215/40 (20130101) C07D 223/18 (20130101) Original (OR) Class C07D 231/12 (20130101) C07D 233/24 (20130101) C07D 239/26 (20130101) C07D 277/28 (20130101) C07D 413/14 (20130101) C07D 417/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340538 | Castor |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trevor Percival Castor (, None) |
| ASSIGNEE(S) | Trevor P. Castor (Woburn, Massachusetts) |
| INVENTOR(S) | Trevor Percival Castor (, None) |
| ABSTRACT | This invention is for improving the manufacturing pharmaceutical grade CBD and other cannabinoids following current Good Manufacturing Practices (cGMP) of the US FDA for use in clinical trials for CNS and other indications by the NIH and other researchers. The major cannabinoids in marijuana (Cannabis) and hemp originate from Cannabigerolic Acid (CBGA) present in the biomass of the plant. Plant enzymes that are specific to different strains of biomass converts CBGA to different carboxylic acids of cannabinoids including Cannabidiolic Acid (CBDA) and Δ9-Tetrahydrocannabinolic Acid (Δ9-THCA). These are relatively stable in the growing and fresh-cut plants. These are converted by thermal decarboxylation to Cannabidiol (CBD) and Δ9-Tetrahydrocannabinol (Δ9-THC), carbon dioxide and water. Cannabinoids can be manufactured by first heating the Cannabis biomass to convert carboxylic acids prior to extraction and purification. Alternatively, and preferably because of manufacturing cost and product stability, the carboxylic acids can be first extracted and purified. They can be utilized in the carboxylic acid form or stored in a stable manner until converted to cannabinoids for use in medicine. This invention provides an efficient method for their conversion utilizing a high-pressure reactor under inert conditions. |
| FILED | Sunday, April 24, 2022 |
| APPL NO | 17/727788 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 3/04 (20130101) Acyclic or Carbocyclic Compounds C07C 37/50 (20130101) C07C 37/74 (20130101) C07C 39/19 (20130101) Heterocyclic Compounds C07D 311/80 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340557 | Tan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Memorial Sloan-Kettering Cancer Center (New York, New York); The Regents of the University of California (Oakland, California); University of Central Florida Research Foundation, Inc. (Orlando, Florida); The Broad Institute, Inc. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Memorial Sloan-Kettering Cancer Center (New York, New York); The Regents of the University of California (Oakland, California); University of Central Florida Research Foundation, Inc. (Orlando, Florida); The Broad Institute, Inc. (Cambridge, Massachusetts) |
| INVENTOR(S) | Derek Shieh Tan (New York, New York); Corinne N. Foley (New York, New York); Gustavo Moura-Letts (New York, New York); James McKerrow (New York, New York); Sivaraman Dandapani (Wakefield, Massachusetts); Rahul Edwankar (New York, New York); Alyssa Verano (New York, New York); Debopam Chakrabarti (Winter Springs, Florida); Bracken Roberts (Oviedo, Florida) |
| ABSTRACT | The present disclosure provides compounds of Formula (I′), Formula (II), and Formula (III). The compounds described herein may useful in treating and/or preventing protozoan infections in a subject in need thereof, treating and/or preventing trypanosomal infections (e.g., Trypanosoma cruzi (T. cruzi) or Trypanosoma brucei infections) and/or plasmodial infections in a subject in need thereof, treating and/or preventing diseases in a subject in need thereof (e.g., Chagas disease, malaria, and/or sleeping sickness), and may be useful in treating and/or preventing infectious diseases in a subject in need thereof. Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including a compound described herein. |
| FILED | Monday, November 22, 2021 |
| APPL NO | 17/532036 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 33/00 (20180101) A61P 33/06 (20180101) Heterocyclic Compounds C07D 471/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340558 | Fuller et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alkermes, Inc. (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nathan Oliver Fuller (Arlington, Massachusetts); John A. Lowe, III (Stonington, Connecticut) |
| ABSTRACT | Provided herein are compounds and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of conditions associated with inhibition of HDAC (e.g., HDAC2). |
| FILED | Wednesday, December 22, 2021 |
| APPL NO | 17/558840 |
| CURRENT CPC | Heterocyclic Compounds C07D 471/04 (20130101) Original (OR) Class C07D 487/04 (20130101) C07D 513/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340560 | Fuller et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alkermes, Inc. (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nathan Oliver Fuller (Arlington, Massachusetts); John A. Lowe, III (Stonington, Connecticut) |
| ABSTRACT | Provided herein are compounds and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of conditions associated with inhibition of HDAC (e.g,. HDAC2). |
| FILED | Wednesday, December 22, 2021 |
| APPL NO | 17/559488 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/437 (20130101) A61K 31/519 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Heterocyclic Compounds C07D 471/04 (20130101) Original (OR) Class C07D 487/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340568 | Feng et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio); Reaction Biology Corporation (Malvern, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yangbo Feng (Malvern, Pennsylvania); Sung Ok Yoon (Columbus, Ohio) |
| ABSTRACT | Described herein are compounds that are kinase inhibitors. The disclosed compounds have improved properties that lead to specific targeting of kinases without inhibiting the activity of related enzymes including, making them useful for therapeutic intervention in a variety of disorders and disease in which inhibition of the kinase can be clinically useful, e.g., Alzheimer's disease and other neurodegenerative diseases. In further aspects, the disclosed compounds can be used in methods of treating a neurodegenerative disease associated with inflammation, such as Alzheimer's disease, Huntington's disease, Parkinson's disease, epilepsy, stroke, amyotrophic lateral sclerosis (ALS), spinal muscular atrophy (SMA), or a disease or disorder such as deafness, glaucoma, organ failure, or cancers, including, but not limited to, those susceptible to combination therapy with epigenetic targets such as those associated with bromodomain (BRD) proteins, histone deacetylases (HDACs), and the like. |
| FILED | Thursday, September 10, 2020 |
| APPL NO | 17/753651 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Heterocyclic Compounds C07D 409/14 (20130101) C07D 471/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340619 | LE NOUEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE USA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (BETHESDA, Maryland); CODAGENIX, INC. (STONY BROOK, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cyril LE NOUEN (Bethesda, Maryland); Ursula J. BUCHHOLZ (Silver Spring, Maryland); Peter L. COLLINS (Silver Spring, Maryland); Steffen MUELLER (Farmingdale, New York) |
| ABSTRACT | Reported herein are presumptively de-attenuating mutations that are useful, either individually or in combinations that may include other known mutations, in producing recombinant strains of human respiratory syncytial virus (RSV) exhibiting attenuation phenotypes. Also described herein is a novel RSV construct, Min_L-NPM2-1(N88K)L, which exhibits an attenuated phenotype, is stable and is as immunogenic as wild type RSV. The recombinant RSV strains described here are suitable for use as live-attenuated RSV vaccines. Exemplary vaccine candidates are described. Also provided are polynucleotide sequences capable of encoding the described viruses, as well as methods for producing and using the viruses. |
| FILED | Tuesday, June 28, 2022 |
| APPL NO | 17/851905 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0043 (20130101) A61K 39/155 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/20 (20180101) Peptides C07K 14/08 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/04 (20130101) C12N 2760/00021 (20130101) C12N 2760/00034 (20130101) C12N 2760/00062 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340629 | Griffin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California); SHANGPHARMA INNOVATION (South San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John H. Griffin (Del Mar, California); Hiroshi Deguchi (San Diego, California); Weijun Shen (San Diego, California); Sam Lear (Del Mar, California); Elsa Pflimlin (Koetzingue, France); Yvonne Marie Angell (San Carlos, California); Mike Lizarzaburu (Pacifica, California) |
| ABSTRACT | The present invention provides myosin derived peptides, variants and derivative compounds that are anti-coagulant. Also provided in the invention are antibodies that specifically target the peptides or epitopes presented thereon. Further provided in the invention are methods directed to using the anti-coagulant compounds described herein in therapeutic applications, e.g., inhibiting myosin-supported prothrombin activation to reduce the risk of acute trauma coagulopathy in post-trauma patients or inhibiting cardiac myosin-supported prothrombin activation to reduce the risk of coronary thrombosis. |
| FILED | Wednesday, May 25, 2022 |
| APPL NO | 17/824186 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1719 (20130101) A61K 47/543 (20170801) Peptides C07K 14/4716 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340636 | MENTING et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF UTAH RESEARCH FOUNDATION (Salt Lake City, Utah); THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (Parkville, Australia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Gerbrandt Tasman MENTING (Bulleen, Australia); Brian SMITH (Bundoora, Australia); Danny Hung-Chieh CHOU (Salt Lake City, Utah); Helena SAFAVI-HEMAMI (Salt Lake City, Utah); Michael Colin LAWRENCE (Newport, Australia); Baldomero M. OLIVERA (Salt Lake City, Utah) |
| ABSTRACT | The present invention relates to insulin analogs, particularly insulin analogs having shortened B chains. The present invention also relates to the crystal structure of insulin from the venom of cone snails and to methods of using the crystal and related structural information to screen for and design insulin analogs that interact with or modulate the insulin receptor. The present invention also relates to therapeutic and prophylactic methods using insulin analogs. |
| FILED | Tuesday, January 04, 2022 |
| APPL NO | 17/568698 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/62 (20130101) Original (OR) Class C07K 14/43509 (20130101) Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 7/02 (20130101) C30B 29/58 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340637 | ROYBAL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kole T. ROYBAL (San Francisco, California); Raymond LIU (San Francisco, California); Iowis ZHU (San Francisco, California) |
| ABSTRACT | The present disclosure generally relates to, inter alia, a new class of receptors engineered to modulate transcriptional regulation in a ligand-dependent manner. Particularly, the new receptors, even though derived from Notch, do not require the Notch negative regulatory regions previously believed to be essential for the functioning of the receptors. In addition, the new receptors described herein incorporate a flexible polypeptide connector region disposed between the extracellular ligand-binding domain (ECD) and the transmembrane domain (TMD) which facilitates optimizing the stiffness/flexibility of the chimeric polypeptides to achieve a desired activity. The disclosure also provides compositions and methods useful for producing such receptors, nucleic acids encoding same, host cells genetically modified with the nucleic acids, as well as methods for modulating an activity of a cell and/or for the treatment of various health conditions such as diseases (e.g., cancers). |
| FILED | Wednesday, September 23, 2020 |
| APPL NO | 17/762685 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 38/1774 (20130101) A61K 39/39558 (20130101) A61K 45/06 (20130101) A61K 2039/5156 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Peptides C07K 14/705 (20130101) Original (OR) Class C07K 16/2803 (20130101) C07K 2317/76 (20130101) C07K 2317/622 (20130101) C07K 2319/03 (20130101) C07K 2319/33 (20130101) C07K 2319/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340643 | Yurchenco et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter D. Yurchenco (New Brunswick, New Jersey); Karen K. McKee (New Brunswick, New Jersey) |
| ABSTRACT | The present invention relates to recombinant laminin adeno-associated viral vector (AAV) constructs and related methods for restoring laminin expression in deficient mammals, or in mammals with basement membrane instability. |
| FILED | Friday, September 11, 2020 |
| APPL NO | 17/642399 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) Peptides C07K 14/78 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340663 | Chan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Memorial Sloan Kettering Cancer Center (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Timothy A. Chan (Cortlandt Manor, New York); Diego Chowell Puente (New York, New York); Robert M. Samstein (New York, New York); Luc Morris (New York, New York) |
| ABSTRACT | The present invention encompasses the discovery that the likelihood of a favorable response to cancer immunotherapy for a wide range of different cancers can be predicted through definition of a tumor mutational load threshold for the tumor (and/or the relevant immunotherapy). |
| FILED | Monday, November 29, 2021 |
| APPL NO | 17/536715 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/395 (20130101) A61K 2039/876 (20180801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2818 (20130101) C07K 16/2827 (20130101) Original (OR) Class C07K 16/2896 (20130101) C07K 2317/76 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6827 (20130101) C12Q 1/6881 (20130101) C12Q 1/6886 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340670 | Banchereau et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BAYLOR RESEARCH INSTITUTE (Dallas, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jacques F. Banchereau (Montclair, New Jersey); Gerard Zurawski (Midlothian, Texas); Sandra Zurawski (Midlothian, Texas); SangKon Oh (Baltimore, Maryland) |
| ABSTRACT | The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccine and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies. |
| FILED | Monday, March 07, 2022 |
| APPL NO | 17/687971 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/00 (20130101) Peptides C07K 14/005 (20130101) C07K 16/2878 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340849 | Pediaditakis et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | EMULATE, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Iosif Pediaditakis (Boston, Massachusetts); William R. Tien-Street (Burtonsville, Maryland); S. Jordan Kerns (Reading, Massachusetts); Geraldine Hamilton (Boston, Massachusetts); Daniel Levner (Brookline, Massachusetts) |
| ABSTRACT | The invention relates to modeling brain neuronal disease in a microfluidic device, comprising a co-culture of iPS-derived brain endothelial cells; iPS-derived dopaminergic neurons; primary microglia; and primary astrocytes, a Blood-Brain-Barrier (BBB)-Chip and a Brain-Chip. In particular, cross-talk between glial cells (e.g. microglia and astrocytes) with neuronal cells, in further contact with endothelial cells is contemplated for use for identifying drug targets under conditions for inducing in vivo relevant neuronal inflammation, neurodegeneration and neuronal death. Thus, in one embodiment, a microfluidic Brain-Chip comprising a co-culture of brain cells is exposed to α-synuclein preformed fibrils (PFF), a type of pathogenic form of α-synuclein. Such α-synuclein PFF exposure demonstrates an in vivo relevant disease pathogenesis on a microfluidic device as a concentration- and time-controlled manner that may be used for preclinical drug evaluation for diseases related to neuronal inflammation, e.g. Parkinson's disease (PD). In some embodiments, modulation of complement in the presence of neuronal inflammation is contemplated. In some embodiments, drug delivery to brain cells across the BBB is contemplated for preclinical testing of drug efficacy for slowing or stopping neuronal inflammation and degeneration. |
| FILED | Wednesday, April 13, 2022 |
| APPL NO | 17/719627 |
| CURRENT CPC | Peptides C07K 14/47 (20130101) Apparatus for Enzymology or Microbiology; C12M 23/16 (20130101) Original (OR) Class C12M 25/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0075 (20130101) C12N 5/0618 (20130101) C12N 2502/086 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5058 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340876 | Birnbaum et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Michael Birnbaum (Somerville, Massachusetts); Connor Dobson (Somerville, Massachusetts); Stephanie Gaglione (Cambridge, Massachusetts); Kole Roybal (San Francisco, California); Cassandra Burnett (San Francisco, California) |
| ABSTRACT | Disclosed herein are compositions of retroviruses and methods of using the same for gene delivery to a hematopoietic stem cell (HSC), wherein the retroviruses comprise a viral envelope protein comprising at least one mutation that diminishes its native function, a non-viral membrane-bound protein comprising a membrane-bound domain and an extracellular targeting domain. |
| FILED | Saturday, April 16, 2022 |
| APPL NO | 17/722312 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0647 (20130101) Original (OR) Class C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/86 (20130101) C12N 15/625 (20130101) C12N 2310/20 (20170501) C12N 2740/15022 (20130101) C12N 2740/15023 (20130101) C12N 2740/15042 (20130101) C12N 2740/15044 (20130101) C12N 2740/15045 (20130101) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340892 | Awasthi |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Regents of The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sanjay Awasthi (Lubbock, Texas) |
| ABSTRACT | Partial depletion of RLIP76 in p53 deficient living subject has shown many health benefits. In one embodiment, partical Rlip depletion is used to prevent or treat cancer in p53 deficient living subjects. In another embodiment, partial Rlip depletion is used for reversion of DNA-methylation abnormalities caused by the lack of p53 to normal in p53 deficient living subjects. In yet another embodiment, partial Rlip depletion is used in reduction of blood glucose, insulin-resistance, hyperlipidemina, or any combination thereof in p53 deficient living subjects. Methods of using liposome containing anti-sense nucleic acid or double stranded siRNA to partially deplete RLIP76 and thus treat p53 deficient subject are disclosed. The approaches described herein can be especially helpful in preventing cancer in Li-Fraumeni patients. |
| FILED | Wednesday, June 01, 2022 |
| APPL NO | 17/830027 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/40 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0693 (20130101) C12N 9/00 (20130101) C12N 11/18 (20130101) C12N 15/11 (20130101) C12N 15/113 (20130101) C12N 15/1024 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340898 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sidi Chen (Milford, Connecticut); Lupeng Ye (New Haven, Connecticut); Jonathan Park (Scott AFB, Illinois); Matthew Dong (San Francisco, California); Ryan D. Chow (San Jose, California) |
| ABSTRACT | The present invention includes compositions and methods for identification of membrane targets for enhancement of T cell activity against a disease, disorder or condition, and/or enhancing T cell anti-tumor activity in a subject in need thereof. In some embodiments, the disease is cancer. In further embodiments, the cancer is glioblastoma (GBM) or breast cancer. |
| FILED | Wednesday, July 31, 2019 |
| APPL NO | 17/264691 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/90 (20130101) C12N 15/111 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2800/90 (20130101) Enzymes C12Y 204/01155 (20130101) C12Y 503/04001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340902 | Pyle et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anna Marie Pyle (Guilford, Connecticut); Akiko Iwasaki (Guilford, Connecticut); Tianyang Mao (New Haven, Connecticut) |
| ABSTRACT | The present disclosure provides small hairpin nucleic acid molecules capable of stimulating interferon production. The nucleic acid molecules of the present disclosure has a double-stranded section of less than 19 base pairs and at least one blunt end. In certain embodiments, the molecule comprises at least one 5′-triphosphate and/or at least one 5′-diphosphate. In certain embodiments, compounds and/or compositions of the disclosure are useful for treating, ameliorating, and/or preventing SARS-CoV-2 viral infection, and/or ameliorating, minimizing, reversing, and/or preventing persistent SARS-CoV-2 viral infection, and/or minimizing or preventing SARS-CoV-2 viral infection-derived mortality and/or lethality, in a subject. In certain embodiments, compounds and/or compositions of the disclosure are useful for treating, ameliorating, and/or preventing SARS-CoV-2 viral infection in a tumor-bearing subject. In certain embodiments, compounds and/or compositions of the disclosure are useful for treating, ameliorating, and/or preventing SARS-CoV-2 viral infection in an immune-compromised and/or immunodeficient subject. |
| FILED | Wednesday, March 30, 2022 |
| APPL NO | 17/709282 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/531 (20130101) C12N 2320/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340903 | Bach et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Massachusetts (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ingolf Bach (Framingham, Massachusetts); Feng Wang (Shrewsbury, Massachusetts); Anastasia Khvorova (Westborough, Massachusetts); Chantal Ferguson (Worcester, Massachusetts) |
| ABSTRACT | Methods for the treatment of weight-related disorders, including obesity and disorders associated with obesity, as well as underweight and disorders associated with underweight, by modulating Rlim levels. |
| FILED | Friday, September 25, 2020 |
| APPL NO | 17/760504 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/312 (20130101) C12N 2310/315 (20130101) C12N 2310/3515 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340906 | LIEBERMAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| INVENTOR(S) | Judy LIEBERMAN (Brookline, Massachusetts); Ying ZHANG (Boston, Massachusetts) |
| ABSTRACT | The technology described herein is directed to improved chimeric molecules for, e.g, the treatment of cancer. As described herein, the inventors have developed novel chimeric aptamer-siRNA molecules (AsiCs) which demonstrate improved efficacy over existing AsiCs and which can successfully synergize in treating cancer. These AsiC's target cancer cell markers to direct therapeutic siRNA molecules specifically to cancer cells, increasing delivery efficacy and therapeutic effectiveness while reducing the potential for side effects. |
| FILED | Thursday, June 18, 2020 |
| APPL NO | 17/619712 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/00 (20130101) A61K 47/10 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/115 (20130101) Original (OR) Class C12N 15/1138 (20130101) C12N 2310/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340908 | Haynes et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cole Haynes (Holden, Massachusetts); Qiyuan Yang (Shrewsbury, Massachusetts) |
| ABSTRACT | Methods and compositions to deplete deleterious mitochondrial genomes (ΔmtDNAs), resulting in a compensatory increase in WT mtDNAs, by inhibition of LONP1, e.g., by inhibitory nucleic acids (including RNAi); inducing mutations that prevent the protease from binding mtDNA; or administering an inhibitor, e.g., the clinically relevant compound CDDO-Me (Bardoxolone), all of which result in the preferential loss of ΔmtDNAs. |
| FILED | Friday, September 25, 2020 |
| APPL NO | 17/642986 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/36 (20130101) A61K 31/277 (20130101) A61K 31/365 (20130101) A61K 31/496 (20130101) A61K 38/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 43/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/14 (20130101) C12N 2310/3231 (20130101) C12N 2310/3513 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340936 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| INVENTOR(S) | Feng Zhang (Cambridge, Massachusetts); Jonathan Schmid-Burgk (Cambridge, Massachusetts); Suchita Nety (Cambridge, Massachusetts) |
| ABSTRACT | An engineered system for modulating a nucleic acid molecule. In some examples, the system comprises a programmable inducer of DNA damage; one or more functional domain such as a reverse transcriptase domain, topoisomerase domain and/or polymerase domain; a recombination enhancer domain; and an RNA template encoding a donor polynucleotide and capable of forming a complex with the RT domain. |
| FILED | Monday, September 28, 2020 |
| APPL NO | 17/763907 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) C12N 15/102 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340952 | Kirby et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | James E. Kirby (Weston, Massachusetts); Ramy Arnaout (Chestnut Hill, Massachusetts); Kenneth P. Smith (Somerville, Massachusetts); Matthew Ware (Merrimack, Massachusetts) |
| ABSTRACT | Embodiments allow for rapid antimicrobial susceptibility testing (AST) at a low cost. Embodiments may use changes in the pixel intensity from reflected light to determine microorganism growth and antimicrobial resistance. Dilutions of an antimicrobial are added to a standard well plate or other array. A pathogen or other microorganism may be added to the dilutions in the well plate. The well plate may be incubated for a time period less than 3 hours. The well plate may then be imaged and the resulting image data may be analyzed. Wells where the microorganism is able to grow may appear darker than wells where the microorganism did not grow. Differences pixel intensity of the wells is used to determine the susceptibility or resistance of the microorganism to the antimicrobial. The image data may be used to determine the minimum inhibitory concentration (MIC), the lowest dilution concentration of antimicrobial that inhibits growth. |
| FILED | Monday, September 28, 2020 |
| APPL NO | 17/765328 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/18 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 35/10 (20130101) G01N 35/028 (20130101) G01N 2035/00356 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/20081 (20130101) G06T 2207/30072 (20130101) Pictorial Communication, e.g Television H04N 5/2256 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340972 | MONAGHAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rhode Island Hospital (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sean F. MONAGHAN (East Greenwich, Rhode Island); Gerard J. NAU (Sharon, Massachusetts); Alger M. FREDERICKS (East Providence, Rhode Island) |
| ABSTRACT | Deep RNA sequencing is a technology that provides an initial diagnostic for sepsis that can also monitor the indicia of treatment and recovery (bacterial counts reduce, physiology returns to steady-state). The invention can be used for many other hospital conditions, particularly those needing an intensive care unit stay with the attendant risk of bacterial infection, such as trauma, stroke, myocardial infarction, or major surgery. |
| FILED | Monday, April 18, 2022 |
| APPL NO | 17/723271 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) C12Q 1/701 (20130101) C12Q 1/6883 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340977 | Willey et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of Toledo (Toledo, Ohio) |
| ASSIGNEE(S) | The University of Toledo (Toledo, Ohio) |
| INVENTOR(S) | James C. Willey (Toledo, Ohio); Daniel J. Craig (Toledo, Ohio); Thomas M. Blomquist (Toledo, Ohio); Erin L. Crawford (Toledo, Ohio); Ji-Youn Yeo (Toledo, Ohio) |
| ABSTRACT | Kits and methods for diagnosing risk of developing lung cancers and uses thereof are described. In a first aspect, described herein are lung cancer risk test kits that include reagents for measurement of multiple low VAF (defined as VAF<1%) mutants in a set of lung cancer driver genes; and, instructions therefor. |
| FILED | Tuesday, September 08, 2020 |
| APPL NO | 17/640610 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/16 (20130101) C12Q 2600/118 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340980 | Kurtz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | David M. Kurtz (San Francisco, California); Maximilian Diehn (San Carlos, California); Arash Ash Alizadeh (San Mateo, California) |
| ABSTRACT | Processes and materials to detect cancer from a biopsy are described. In some cases, cell-free nucleic acids can be sequenced, and the sequencing result can be utilized to detect sequences derived from a neoplasm. Detection of somatic variants occurring in phase can indicate the presence of cancer in a diagnostic scan and a clinical intervention can be performed. |
| FILED | Monday, May 02, 2022 |
| APPL NO | 17/661730 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1089 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) C12Q 1/6874 (20130101) C12Q 1/6886 (20130101) Original (OR) Class Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/10 (20190201) G16B 20/20 (20190201) G16B 30/00 (20190201) G16B 30/10 (20190201) G16B 35/20 (20190201) G16B 40/00 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/40 (20180101) G16H 10/60 (20180101) G16H 20/10 (20180101) G16H 50/20 (20180101) G16H 50/30 (20180101) G16H 50/70 (20180101) G16H 70/60 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220341540 | Andrews et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BRIGHAM YOUNG UNIVERSITY (Provo, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David W. Andrews (Provo, Utah); Spencer P. Magleby (Provo, Utah); Larry L. Howell (Orem, Utah) |
| ABSTRACT | An example deployable structure includes at least one base member, at least one first articulable member, at least one second articulable member, and at least one interference member. The deployable structure must include at least one base member, at least one first articulable member, at least one second articulable member, and at least one interference member otherwise the deployable structure may not be switchable between the compact and deployed states thereof. The base member is articulably connected to the first articulable member using a first hinge, the first articulable member is articulably connected to the second articulable member using a second hinge, and the interference member is articulably connected to the second articulable member using a third hinge. The interference member is also attached to the base member, for example, using a fourth hinge. The deployable structure is configured to switch from at least a compact state to a deployed state. |
| FILED | Thursday, April 21, 2022 |
| APPL NO | 17/726282 |
| CURRENT CPC | Frames, Casings or Beds of Engines, Machines or Apparatus, Not Specific to Engines, Machines or Apparatus Provided for Elsewhere; Stands; Supports F16M 13/022 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220341915 | Tata et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | DUKE UNIVERSITY (Durham, North Carolina) |
| ASSIGNEE(S) | DUKE UNIVERSITY (Durham, North Carolina) |
| INVENTOR(S) | Purushothama Rao Tata (Durham, North Carolina); Aleksandra Tata (Durham, North Carolina); Arvind Konkimalla (Durham, North Carolina); Yoshihiko Kobayashi (Durham, North Carolina) |
| ABSTRACT | The present disclosure provides a newly-identified transitional cell state in alveolar regeneration, models to ablate lung alveolar type-1 cells that leads to lung fibrosis and emphysema, a scalable, an ex vivo lung fibrosis model that uses co-cultured lung fibroblasts and pre-alveolar type-1 transitional cell state (PATS) for the use of disease modeling and drug screening, and methods of using same. |
| FILED | Monday, September 28, 2020 |
| APPL NO | 17/763991 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0688 (20130101) C12N 2501/135 (20130101) C12N 2502/27 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5023 (20130101) Original (OR) Class G01N 33/5088 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220341935 | OSTRER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MORGAN AND MENDEL GENOMICS, INC. (New York, New York); ALBERT EINSTEIN COLLEGE OF MEDICINE (Bronx, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Harry OSTRER (New York, New York); Johnny C. LOKE (Valley Cottage, New York); Ishraq ALIM (New York, New York) |
| ABSTRACT | Heritable pathogenic variants in the mismatch repair (MMR) pathway, also known as Lynch Syndrome (LS), can lead to the development of colon cancer and other cancers. Following mismatch, a complex of proteins consisting of MLH1, MSH2, MSH6 and PMS2 translocate into the nucleus to signal recruitment of repair mechanisms. Flow cytometry-based, functional variant assays (FVAs), were developed to determine whether variants in these MMR repair genes and/or other related genes would augment the nuclear translocation of MLH1 and MSH2 and downstream nuclear phosphorylation of ATM and ATR in response to DNA mismatches. Each assay distinguished pathogenic variants in MMR repair genes (MLH1, MSH2, PMS2 and MSH6) from benign controls. The combination of multiple assays provided robust separation between heterozygous pathogenic variant carriers and benign controls. The ability to produce distinct molecular phenotypes by these assays suggest FVA assays of MMR pathways could be used to identify LS and associated risk of colon and other cancers and could act as an adjunct to MMR gene sequencing panels in categorizing variants. |
| FILED | Thursday, May 19, 2022 |
| APPL NO | 17/748522 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6804 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57419 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220342021 | Sun |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Phillip Zhe Sun (Atlanta, Georgia) |
| ABSTRACT | The devices, systems, and methods can improve magnetic resonance imaging (MRI), MR spectroscopy (MRS), MR spectroscopic imaging (MRSI) measurement(s), thereby providing more reliable quantification. The method may include a method for correcting MR image(s)/spectrum. The method may include providing an inhomogeneity field/response map of a region of interest; and providing MR image(s)/spectrum of the region of interest. The method may include determining an intravoxel/voxel inhomogeneity correction coefficient for each voxel of at least one subregion of the region of the interest using the inhomogeneity field/response map. The method may include correcting each voxel of the MR image(s)/spectrum of the region of interest using the intravoxel/voxel inhomogeneity correction coefficient. The MR image(s)/spectrum may include chemical exchange saturation transfer (CEST)/magnetization transfer (MT) imaging with Z-spectrum, CEST/MT imaging without Z-spectrum, CEST spectroscopy, CEST MRS, MRS, MRSI, or any combination thereof. |
| FILED | Tuesday, June 30, 2020 |
| APPL NO | 17/639276 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/445 (20130101) G01R 33/483 (20130101) G01R 33/5605 (20130101) G01R 33/5608 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220342095 | OLCOTT et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | RefleXion Medical, Inc. (Hayward, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter Demetri OLCOTT (Los Gatos, California); Matthew Francis BIENIOSEK (Danville, California); Brent HARPER (New Glarus, Wisconsin) |
| ABSTRACT | Disclosed herein are methods and devices for the acquisition of positron emission (or PET) data in the presence of ionizing radiation that causes afterglow of PET detectors. In one variation, the method comprises adjusting a coincidence trigger threshold of the PET detectors during a therapy session. In one variation, the method comprises adjusting a gain factor used in positron emission data acquisition (e.g., a gain factor used to multiply and/or shift the output(s) of a PET detector(s)) during a therapy session. In some variations, a method for acquiring positron emission data during a radiation therapy session comprises suspending communication between the PET detectors and a signal processor of a controller for a predetermined period of time after a radiation pulse has been emitted by the linac. |
| FILED | Thursday, March 17, 2022 |
| APPL NO | 17/697828 |
| CURRENT CPC | Measurement of Nuclear or X-radiation G01T 1/172 (20130101) G01T 1/208 (20130101) G01T 1/2023 (20130101) G01T 1/2985 (20130101) Original (OR) Class G01T 7/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220342233 | GAWNE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE UAB RESEARCH FOUNDATION (Birmingham, Alabama) |
| ASSIGNEE(S) | THE UAB RESEARCH FOUNDATION (Birmingham, Alabama) |
| INVENTOR(S) | Timothy Jerner GAWNE (Birmingham, Alabama); Thomas Tolles NORTON (Birmingham, Alabama) |
| ABSTRACT | A method of improving emmetropization or slowing myopia development in an eye is provided that involves adjusting the vision in the eye to achieve one or both of increase the distance between the long-wavelength focal plane and the short wavelength focal plane; and position the short wavelength focal plane closer to the cornea than it would normally be located. Multi-spectral devices (e.g., lenses and spectacles) are provided that are useful to improve emmetropization or preventing or reducing the development of myopia, which are optionally multi-focal as well. |
| FILED | Monday, August 31, 2020 |
| APPL NO | 17/761806 |
| CURRENT CPC | Spectacles; Sunglasses or Goggles Insofar as They Have the Same Features as Spectacles; Contact Lenses G02C 7/06 (20130101) G02C 7/022 (20130101) Original (OR) Class G02C 7/044 (20130101) G02C 2202/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220343564 | Hosseini et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Siemens Healthcare GmbH (Erlangen, Germany); The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zahra Hosseini (Atlanta, Georgia); Bryan Clifford (Malden, Massachusetts); Thorsten Feiweier (Poxdorf, Germany); Stephan Kannengiesser (Wuppertal, Germany); Marcel Dominik Nickel (Herzogenaurach, Germany); Stephen Farman Cauley (Somerville, Massachusetts) |
| ABSTRACT | The present disclosure is generally directed to systems and methods for generating de-noised MR images that are reconstructed from a hybridization of two separate image reconstruction pipelines, at least one of which includes the use of a neural network. Further, the amount of influence that the neural network reconstruction has on the hybrid reconstructed image is controlled via a regularization parameter that is selected based on an estimated noise level associated with the initial image acquisition, which can be calculated from pre-scan data. |
| FILED | Wednesday, March 16, 2022 |
| APPL NO | 17/655013 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/7264 (20130101) A61B 2576/00 (20130101) Image Data Processing or Generation, in General G06T 11/005 (20130101) Original (OR) Class G06T 2207/10088 (20130101) G06T 2207/20084 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220344002 | JAMES et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Oklahoma Medical Research Foundation (Oaklahoma City, Oklahoma) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Judith Ann JAMES (Edmond, Oklahoma); Melissa E. MUNROE (Edmond, Oklahoma) |
| ABSTRACT | Systemic Lupus Erythematosus is marked by altered immune regulation linked to waxing and waning clinical disease. Embodiments described herein identify sets of biomarkers/mediators and their use for informing and/or predicting a future SLE disease activity event such as an impending SLE flare or SLE-related organ inflammation. Such an approach can be beneficial in the management of lupus. |
| FILED | Friday, September 18, 2020 |
| APPL NO | 17/762281 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/564 (20130101) G01N 2800/54 (20130101) G01N 2800/60 (20130101) G01N 2800/104 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 25/10 (20190201) Original (OR) Class G16B 40/20 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220344060 | KRISTAL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bruce S. KRISTAL (Cohasset, Massachusetts); Matthew J. SNIATYNSKI (Somerville, Massachusetts); Derbiau Frank HSU (Weston, Massachusetts) |
| ABSTRACT | An improved patient monitoring system can include a processor device, a display, a first sensor in communication with the processor device, the first sensor being at least one of an electrocardiogram sensor, a pressure sensor, a blood oxygenation sensor, an image sensor, an impedance sensor, or a physiological sensor. The system can include a second sensor in communication with the processor device, the second sensor being a physiological sensor. The processor device can be configured to utilize the first accuracy, the second accuracy, the first correlation, the second correlation to determine a recommendation for fusing the first data model with the second data model. |
| FILED | Friday, September 04, 2020 |
| APPL NO | 17/640729 |
| CURRENT CPC | Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 40/63 (20180101) G16H 50/50 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220344145 | JARROLD et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin F. JARROLD (Bloomington, Indiana); Aaron A. TODD (Bloomington, Indiana) |
| ABSTRACT | A charge detection mass spectrometer includes an ion trap configured to receive and store ions therein and to selectively release stored ions therefrom, and an electrostatic linear ion trap (ELIT) spaced apart from the ion trap, the ELIT including first and second ion mirrors and a charge detection cylinder positioned therebetween, and means for selectively controlling the ion trap to release at least some of the stored ions therefrom to travel toward and into the ELIT, and for controlling the first and second ion mirrors in a manner which traps in the ELIT a single one of the ions traveling therein and causes the trapped ion to oscillate back and forth between the first and second ion mirrors each time passing through and inducing a corresponding charge on the charge detection cylinder. |
| FILED | Tuesday, September 22, 2020 |
| APPL NO | 17/760501 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 49/406 (20130101) H01J 49/4245 (20130101) Original (OR) Class H01J 49/4265 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20220338454 | SMANSKI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Joseph SMANSKI (Falcon Heights, Minnesota); Siba DAS (Falcon Heights, Minnesota); Maciej MASELKO (Sydney, Australia); Nathan Robert FELTMAN (Lauderdale, Minnesota); Ambuj UPADHYAY (Falcon Heights, Minnesota) |
| ABSTRACT | An engineered genetic incompatibility (EGI) strain of a wild-type organism is designed to include a haplosufficient lethal allele and a haploinsufficient resistance allele. In another aspect, a biocontainment system generally includes a polynucleotide that encodes a coding region whose expression causes infertility or death, a transcription regulatory region operably linked upstream of the coding region and containing a silent mutation, and a polynucleotide that encodes a programmable transcription activator. The programmable transcription activator is engineered to bind to the transcription regulatory region in the absence of the silent mutation, thereby expressing the coding region in the absence of the silent mutation, but does not initiate expression of the coding region when the transcription regulatory region comprises the silent mutation. |
| FILED | Friday, October 30, 2020 |
| APPL NO | 17/763870 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0339 (20130101) Original (OR) Class A01K 2217/05 (20130101) A01K 2227/706 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/113 (20130101) C12N 15/8509 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) C12N 2800/105 (20130101) C12N 2830/001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220338722 | Eden et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the University of lllinois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | J. Gary Eden (Urbana, Illinois); Peter P. Sun (Urbana, Illinois); Wenyuan Chen (Urbana, Illinois); Thanh H. Nguyen (Urbana, Illinois); Guillermo L. Monroy (Urbana, Illinois); Jungeun Won (Urbana, Illinois); Stephen A. Boppart (Urbana, Illinois) |
| ABSTRACT | A speculum body is configured to attach to the otoscope. An array of radially situated microchannels is within the speculum body and extends to apertures in a distal end of the speculum body. A power electrode array is within the speculum body positioned with respect to the microchannels to excite plasma generation within the microchannels. An optically transparent central portion is in the body to permit viewing of an eardrum by a practitioner. A method of treatment of the middle ear and/or middle ear cavity incudes actuating plasma jets to extend into the ear canal from a speculum attached to the otoscope and continuing the plasma jet treatment for a period of time sufficient to inactivate or kill a bacterial biofilm in the middle ear and/or the middle ear cavity. |
| FILED | Wednesday, June 24, 2020 |
| APPL NO | 17/621803 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/227 (20130101) Original (OR) Class Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/44 (20130101) Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 1/2431 (20210501) H05H 2245/30 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220338734 | Hu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University Of Maryland, Baltimore (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fu-Ming Hu (Ellicott City, Maryland); Lynn G. Stansbury (Seattle, Washington); Colin F. Mackenzie (Pasadena, Maryland); Thomas M. Scalea (Baltimore, Maryland); Deborah M. Stein (Owings Mills, Maryland); Shiming Yang (Halethorpe, Maryland) |
| ABSTRACT | A method and apparatus for monitoring collection of subject condition data is provided. The method includes receiving a value of a parameter of subject condition data and a value of a sample time, for each of a plurality of sample times. The method also includes storing the subject condition data in a data structure including a first field for holding data indicating a current sample time and a second field for holding data indicating the value of the parameter. The method also includes determining a time gap defined by a duration between the current sample time and a most recent sample time and determining whether the time gap exceeds a time gap threshold and causing an apparatus to perform remedial action. A method for presenting the subject condition data on a display is also provided. |
| FILED | Monday, February 21, 2022 |
| APPL NO | 17/676657 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0006 (20130101) A61B 5/0008 (20130101) A61B 5/0022 (20130101) Original (OR) Class A61B 5/1113 (20130101) A61B 5/02055 (20130101) A61B 5/02405 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/40 (20180101) G16H 10/60 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220339860 | Knoth |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Dayton Research Institute (Dayton, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Samantha Knoth (Niceville, Florida) |
| ABSTRACT | A process for curing an ultraviolet curable material comprises setting initial conditions, such as an emitted irradiance of an ultraviolet source, an initial value for an exposure time, an initial value for a break time, a stopping condition, combinations thereof, etc. The process repeatedly performs an ultraviolet cure sequence to cure a material until the stopping condition is met, where each iteration in the ultraviolet cure sequence comprises irradiating the material with the ultraviolet source at the emitted irradiance for the exposure time, and resting for the break time with no irradiation applied to the material. In some embodiments, the process adjusts a value of at least one of the emitted irradiance, the exposure time, or the break time in at least one iteration of the ultraviolet cure sequence. For instance, in some embodiments, the exposure time is adjusted, e.g., by a fixed amount, according to a gradient, etc. |
| FILED | Thursday, April 21, 2022 |
| APPL NO | 17/725851 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/129 (20170801) Original (OR) Class B29C 64/264 (20170801) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2031/753 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340252 | MacDonald et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Boeing Company (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elaine MacDonald (Wildwood, Missouri); Jeremy Nicholas O'Hara (University City, Missouri); Daniel Edward Driemeyer (St. Louis, Missouri); Grant G. Gvozdich (Columbia, Illinois); Justin L'Hote (St. Peters, Missouri); Ali Yousefiani (Tustin, California); Nicholas B. Segobiano (St. Louis, Missouri) |
| ABSTRACT | An envelope portion of an airborne craft comprises a metallic outer wall and a metallic inner wall arranged interior to the outer wall. The outer and inner walls delimit an inter-wall volume configured to support a flow of coolant to cool the outer wall during atmospheric heating of the outer wall. |
| FILED | Friday, February 11, 2022 |
| APPL NO | 17/650771 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 1/38 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340516 | Malkas et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | City of Hope (Duarte, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Linda H. Malkas (Duarte, California); David Horne (Altadena, California); Robert J. Hickey (Duarte, California); Long Gu (Duarte, California) |
| ABSTRACT | Described herein, inter alia, are compositions of PCNA modulators and methods for treating or preventing cancer. |
| FILED | Wednesday, April 27, 2022 |
| APPL NO | 17/730948 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/167 (20130101) A61K 31/4409 (20130101) A61K 31/4418 (20130101) A61K 31/4725 (20130101) A61K 33/243 (20190101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 35/02 (20180101) Acyclic or Carbocyclic Compounds C07C 233/76 (20130101) Original (OR) Class C07C 237/22 (20130101) Heterocyclic Compounds C07D 213/68 (20130101) C07D 217/26 (20130101) C07D 401/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340622 | JONES et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Justin A. JONES (Nibley, Utah); Randolph V. Lewis (Nibley, Utah); Dong Chen (Logan, Utah); Paula F. Oliveira (Logan, Utah); Thomas Ian Harris (Logan, Utah); Brianne Eileen Bell (Nibley, Utah) |
| ASSIGNEE(S) | Utah State University (Logan, Utah) |
| INVENTOR(S) | Justin A. JONES (Nibley, Utah); Randolph V. Lewis (Nibley, Utah); Dong Chen (Logan, Utah); Paula F. Oliveira (Logan, Utah); Thomas Ian Harris (Logan, Utah); Brianne Eileen Bell (Nibley, Utah) |
| ABSTRACT | The present application provides fibers made from recombinant hagfish intermediate filament proteins. Methods of expressing and purifying the proteins, and methods of creating the fibers, are likewise disclosed. The method of purifying protein yields larger quantities of hagfish protein than have been previously achieved, and the fibers have the highest mechanical properties yet recorded for recombinant hagfish protein fibers. |
| FILED | Monday, February 14, 2022 |
| APPL NO | 17/651020 |
| CURRENT CPC | Peptides C07K 14/461 (20130101) Original (OR) Class Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 4/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340644 | EASTERHOFF et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David EASTERHOFF (Durham, North Carolina); Gregory SEMPOWSKI (Durham, North Carolina) |
| ABSTRACT | The invention relates to human antibodies binding to and neutralizing Influenza (flu) virus and their uses. |
| FILED | Friday, September 18, 2020 |
| APPL NO | 17/761960 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) Peptides C07K 16/1018 (20130101) Original (OR) Class C07K 2317/52 (20130101) C07K 2317/55 (20130101) C07K 2317/565 (20130101) C07K 2317/622 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340731 | Xu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Ting Xu (Berkeley, California); Christopher DelRe (Berkeley, California); Junpyo Kwon (Berkeley, California) |
| ABSTRACT | Nanoscopic dispersion of trace enzymes and random heteropolymers in plastics provides to fully functional plastics with eco-friendly microplastic elimination and programmable degradation. |
| FILED | Sunday, June 19, 2022 |
| APPL NO | 17/844026 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 11/105 (20130101) Original (OR) Class C08J 2367/04 (20130101) Compositions of Macromolecular Compounds C08L 67/04 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 17/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340898 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sidi Chen (Milford, Connecticut); Lupeng Ye (New Haven, Connecticut); Jonathan Park (Scott AFB, Illinois); Matthew Dong (San Francisco, California); Ryan D. Chow (San Jose, California) |
| ABSTRACT | The present invention includes compositions and methods for identification of membrane targets for enhancement of T cell activity against a disease, disorder or condition, and/or enhancing T cell anti-tumor activity in a subject in need thereof. In some embodiments, the disease is cancer. In further embodiments, the cancer is glioblastoma (GBM) or breast cancer. |
| FILED | Wednesday, July 31, 2019 |
| APPL NO | 17/264691 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/90 (20130101) C12N 15/111 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2800/90 (20130101) Enzymes C12Y 204/01155 (20130101) C12Y 503/04001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220341468 | Kopanski |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | LOCKHEED MARTIN CORPORATION (Bethesda, Maryland) |
| ASSIGNEE(S) | LOCKHEED MARTIN CORPORATION (Bethesda, Maryland) |
| INVENTOR(S) | Krzysztof D. Kopanski (Stratford, Connecticut) |
| ABSTRACT | A system includes a first structure having an upper surface coupled to a second structure by a fastener assembly including a bushing positioned within an opening in the upper surface of the first structure. An inner opening of the bushing defines an inner diameter, and a fastener is at least partially positioned within the bushing. An outer surface of the fastener defines an outer diameter of the fastener. The bushing and the fastener are configured such that a space between the outer surface of the fastener and the inner opening of the bushing defines a gap which increases in size in a direction extending from the upper surface to the lower surface of the first structure. |
| FILED | Friday, April 23, 2021 |
| APPL NO | 17/238575 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 27/48 (20130101) Shafts; Flexible Shafts; Elements or Crankshaft Mechanisms; Rotary Bodies Other Than Gearing Elements; Bearings F16C 17/02 (20130101) F16C 35/02 (20130101) Original (OR) Class F16C 2326/43 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220341540 | Andrews et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BRIGHAM YOUNG UNIVERSITY (Provo, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David W. Andrews (Provo, Utah); Spencer P. Magleby (Provo, Utah); Larry L. Howell (Orem, Utah) |
| ABSTRACT | An example deployable structure includes at least one base member, at least one first articulable member, at least one second articulable member, and at least one interference member. The deployable structure must include at least one base member, at least one first articulable member, at least one second articulable member, and at least one interference member otherwise the deployable structure may not be switchable between the compact and deployed states thereof. The base member is articulably connected to the first articulable member using a first hinge, the first articulable member is articulably connected to the second articulable member using a second hinge, and the interference member is articulably connected to the second articulable member using a third hinge. The interference member is also attached to the base member, for example, using a fourth hinge. The deployable structure is configured to switch from at least a compact state to a deployed state. |
| FILED | Thursday, April 21, 2022 |
| APPL NO | 17/726282 |
| CURRENT CPC | Frames, Casings or Beds of Engines, Machines or Apparatus, Not Specific to Engines, Machines or Apparatus Provided for Elsewhere; Stands; Supports F16M 13/022 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220341689 | Ayotte et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Textron Systems Corporation (Hunt Valley, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin Michael Ayotte (Acworth, Georgia); Benjamin Tyler Cole (Baltimore, Maryland); Leonard Terrence Katilas (Essex, Maryland) |
| ABSTRACT | A belt-fed weapon includes an upper part defining a feed tray cavity, and a feed tray in the feed tray cavity, wherein the feed tray and feed-tray cavity are co-configured for lateral sliding insertion and removal of the feed tray to and from an installed position in the feed tray cavity. The arrangement enables insertion and removal of the feed tray without interference with an installed scope or similar optic, enabling maintenance or field stripping without requiring removal or re-sighting of the scope. |
| FILED | Thursday, March 10, 2022 |
| APPL NO | 17/691571 |
| CURRENT CPC | Functional Features or Details Common to Both Smallarms and Ordnance, e.g Cannons; Mountings for Smallarms or Ordnance F41A 3/66 (20130101) F41A 9/29 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220341713 | Mechinus et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Jesse R. Mechinus (Bloomington, Indiana); Gerald Miller (Bloomington, Indiana); James Stewart (Bloomington, Indiana) |
| ABSTRACT | Provided is a an active shooter monitoring and incapacitation system that can augment active security forces control during emergencies at schools, churches, military, and government institutions. The system includes one or more cameras that are controlled remotely by an operator. If a hostile person or active shooter is located, a warning system, such as an audio/visual alert and laser dazzler is activated to alert nearby people of the threat to vacate and to notify the active shooter that he/she is required to halt any hostile actions. If the hostile person does not cease his activities, one or more stun guns contained within the system are then utilized to incapacitate the active shooter with a large electric shock, thereby incapacitating the person until the authorities arrive. |
| FILED | Tuesday, April 26, 2022 |
| APPL NO | 17/729543 |
| CURRENT CPC | Armour; Armoured Turrets; Armoured or Armed Vehicles; Means of Attack or Defence, e.g Camouflage, in General F41H 11/00 (20130101) Original (OR) Class F41H 13/0012 (20130101) F41H 13/0087 (20130101) Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 21/02 (20130101) Pictorial Communication, e.g Television H04N 5/23203 (20130101) H04N 5/23299 (20180801) H04N 7/181 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220341851 | Marder et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois); Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Seth R. Marder (Atlanta, Georgia); William R. Dichtel (Wilmette, Illinois); Samik Jhulki (Atlanta, Georgia); Stephen Barlow (Atlanta, Georgia); Austin M. Evans (Evanston, Illinois) |
| ABSTRACT | Disclosed herein are sensors comprising a covalent organic framework (COF). The COF comprising a tautomerically active subunits (TAS) capable of reversible iminol-to-ketoenamine tautomerism between a first tautomer and a second tautomer and a inking group. Methods of detecting analytes with the sensors are also disclosed. |
| FILED | Tuesday, September 08, 2020 |
| APPL NO | 17/753517 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/81 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220341875 | Chaplan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | JENTEK Sensors, Inc. (Marlborough, Massachusetts) |
| ASSIGNEE(S) | JENTEK Sensors, Inc. (Marlborough, Massachusetts) |
| INVENTOR(S) | Stuart Chaplan (Marlborough, Massachusetts); Neil Goldfine (Cocoa Beach, Florida); Zachary M. Thomas (Pittsburgh, Pennsylvania) |
| ABSTRACT | A system and method are provided for performing a hole inspection performance study. Specimens for the performance study are made from a reconfigurable set of inspection plates. Each plate includes multiple test holes which are located symmetrically. The plates may be of various thicknesses and materials. Each test hole may or may not have a feature such as a crack or machining notch. Such features may be located at various positions of the hole, such as at an edge, within the bore, and at various circumferential positions. A specimen is formed by stacking two or more plates and securing the stack together with an alignment tool. A variety of specimens may be formed by using different combinations of inspection plates and flipping and rotating the member plates. A hole inspection system is disclosed as well as an inspection procedure and data processing algorithm for inspecting each hole. |
| FILED | Wednesday, April 27, 2022 |
| APPL NO | 17/660979 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/902 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220342023 | Charlot et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | OHIO STATE INNOVATION FOUNDATION (Calumbus, Ohio); Potomac Research LLC (Alexandria, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Noeloikeau Charlot (Columbus, Ohio); Daniel Gauthier (Columbus, Ohio); Andrew Pomerance (Alexandria, Virginia) |
| ABSTRACT | A waveform capture device (WCD) is a flexible measurement system capable of recording complex digital signals on trillionth-of-a-second (ps) time scales. The WCD may be implemented via modular code on an off-the-shelf field-programmable gate-array (FPGA), and incorporates both time-to-digital converter (TDC) and digital storage oscilloscope (DSO) functionality. The device captures a waveform by taking snapshots of a signal as it propagates down an ultra-fast transmission line known as a carry chain (CC). It may be calibrated via a dynamic phase-shifting (DPS) method that requires substantially less data and resources than conventional techniques. |
| FILED | Monday, February 21, 2022 |
| APPL NO | 17/676340 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 13/02 (20130101) G01R 35/005 (20130101) Original (OR) Class Time-interval Measuring G04F 10/005 (20130101) Pulse Technique H03K 19/173 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220342032 | Fleizach et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregory Knowles Fleizach (San Diego, California); Christopher C. Pelham (Chula Vista, California); Mark William Owen (San Diego, California) |
| ABSTRACT | An apparatus and method identify emitters. The apparatus includes a receiver, a parameter estimator, a database, and a correlator. The receiver receives an electromagnetic signal from an emitter and measures actual values of observed parameters of the electromagnetic signal. The parameter estimator surmises surmised values of unobserved parameters from the actual values of the observed parameters. The actual values of the observed parameters and the surmised values of the unobserved parameters characterize the emitter. The database stores one or more entries for each emitter. Each entry specifies an identifier of an emitter and exemplary values of the observed and unobserved parameters. The correlator matches the actual values of the observed parameters and the surmised values of the unobserved parameters with the exemplary values of one of the entries of the emitter from which the receiver receives the electromagnetic signal. The correlator outputs the identifier from this entry in the database. |
| FILED | Wednesday, April 21, 2021 |
| APPL NO | 17/236016 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/021 (20130101) Original (OR) Class G01S 7/027 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220342189 | Oskotsky et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BAE SYSTEMS Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| ASSIGNEE(S) | BAE SYSTEMS Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| INVENTOR(S) | Mark Oskotsky (Mamaroneck, New York); Daniel Engheben (Commack, New York); Vincent Lipari (Whitestone, New York); Michael Russo, JR. (Roslyn, New York) |
| ABSTRACT | A mid-wave infrared (MWIR) discrete zoom lens for use with remote surveillance and identification having a dual focal length of 9 and 6.39 inches and F #2.8 and F #2, respectively. In one case, a full field of view is about 30.8 degrees for a 9 inch focal length configuration and about 43 degrees for a 6.39 inch focal length configuration. The lens is corrected for monochromatic and chromatic aberrations over the wavelength range 5100 nm-3300 nm. The focal plane may constitute a pixel array consisting of MWIR sensitive material (e.g. InSb, HgCdTe, nBn, SLS, etc.) for use in high-resolution, wide-area imaging applications. |
| FILED | Friday, April 23, 2021 |
| APPL NO | 17/238813 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 15/02 (20130101) Original (OR) Class G02B 26/10 (20130101) G02B 26/0816 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220342227 | Kokubun et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| ASSIGNEE(S) | BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| INVENTOR(S) | Daniel N. Kokubun (Waipahu, Hawaii); Mark S. Branham (Oro Valley, Arizona); Sidney Pang (Kaneohe, Hawaii); Mark Segawa (Wahiawa, Hawaii) |
| ABSTRACT | Techniques are provided for laser illumination employing closely spaced laser beams. A system implementing the techniques according to an embodiment includes a semi-cylindrical optical block comprising a curved surface and a planar surface. A first laser source to generate a first laser beam directed to the planar surface, wherein the first laser beam enters the optical block at a first angle that exceeds a critical angle, relative to the planar surface, the critical angle causing total internal reflection, such that the first laser beam is refracted through and exits the optical block. A second laser source to generate a second laser beam directed to the curved surface, wherein the second laser beam enters the optical block at a second angle that exceeds the critical angle, relative to the planar surface, such that the second laser beam is reflected off the planar surface and exits the optical block parallel to the first laser beam exiting from the optical block, the separation based on a location of the entry of the first laser beam into the optical block. The separation of the exiting first and second laser beams is controlled by the selected translation distance. |
| FILED | Friday, June 17, 2022 |
| APPL NO | 17/842913 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 27/48 (20130101) G02B 27/108 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220342583 | Scott et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Alicia Scott (Bloomington, Indiana); Eli Phillips (Springville, Indiana); Logan Hedge (Bloomington, Indiana); Joseph Cesena (Norco, California); James Michael McDonough (Ventura, California); Stephanie Pham (Norco, California); Nathalie Jesenia Huerta (Santa Clara, California); Jared Sarabia (Thousand Oaks, California) |
| ABSTRACT | Methods, apparatus, and/or computer program products for data preprocessing are provided. The invention utilizes selective modular processes that automate data cleaning tasks and provide an initial analysis of datasets using, among other things, Natural Language Processing and Machine Learning methods. The apparatus and methods preprocess text data, clean database data with minimal human intervention, and provide automatic analytical results that include basic data cleaning, spell check, clustering, outlier detection, and natural language processing. Each modular process can be selectively switched on or off based on user input, preprogrammed instructions, or AI inputs. Additionally, any data format may be input as the apparatus and methods are data agnostic and, therefore, are not designed specifically for one type of data or theme of data. The inventive apparatus and methods dramatically reduce preparation time on the front end of data projects. |
| FILED | Tuesday, April 26, 2022 |
| APPL NO | 17/729707 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/0604 (20130101) G06F 3/0652 (20130101) Original (OR) Class G06F 3/0673 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220343126 | Swager et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Timothy Manning Swager (Newton, Massachusetts); Joseph Michael Azzarelli (Cambridge, Massachusetts); Rong Zhu (Waltham, Massachusetts) |
| ABSTRACT | A wireless sensor platform design and a single walled carbon nanotube/ionic liquid-based chemidosimeter system can incorporated into a highly sensitive and selective chemical hazard badge that can dosimetrically detect an analyte down to a sub parts-per-million concentration. |
| FILED | Wednesday, December 01, 2021 |
| APPL NO | 17/539803 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/082 (20130101) A61B 5/4845 (20130101) A61B 2562/029 (20130101) A61B 2562/0285 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/122 (20130101) G01N 27/127 (20130101) G01N 27/4146 (20130101) G01N 33/0057 (20130101) G01N 33/0075 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 19/0717 (20130101) Original (OR) Class Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 50/265 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220343161 | Restuccia et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northeastern University (Boston, None) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Francesco Restuccia (Boston, Massachusetts); Tommaso Melodia (Newton, Massachusetts) |
| ABSTRACT | A networking device, such as an Internet of Things (IoT) device, implements an operative neural network (ONN) to optimize an internal wireless transceiver based on detected radio frequency (RF) spectrum conditions. The wireless transceiver detects the RF spectrum conditions local to the networking device and generates a representation of the RF spectrum conditions. The ONN determines transceiver parameters based on the RF spectrum conditions. A controller causes the representation of the RF spectrum conditions to be transmitted to a network node. Independent of the networking device, a training neural network (TNN) is trained based on the representation of the RF spectrum conditions, and neural network (NN) parameters are generated via the training a function of the representation of the RF spectrum conditions. The controller then reconfigures the ONN based on the NN parameters. |
| FILED | Friday, September 18, 2020 |
| APPL NO | 17/753670 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Original (OR) Class G06N 3/063 (20130101) G06N 3/0454 (20130101) Information and Communication Technology Specially Adapted for the Internet of Things [IOT] G16Y 40/10 (20200101) Wireless Communication Networks H04W 4/70 (20180201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220343701 | KRESGE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Keith F. KRESGE (Columbus, Ohio); Robert D. WARD (Fairfax, Virginia); Jonathan COYLE (Dublin, Ohio) |
| ABSTRACT | The present disclosure provides a system for terrain classification and vehicle suspension sub-system health status indication. The system includes run-time terrain classification circuitry to determine a first terrain classification, for a vehicle travelling on a terrain segment, based on comparing a trained model to suspension sub-system sensor data and vehicle speed data; model accuracy determination circuitry to determine a second terrain classification, for the vehicle travelling on the terrain segment, based on the suspension sub-system sensor data and vehicle speed data and independent of the trained model; and sub-system health determination circuitry to determine a health indication of the suspension sub-system by comparing a difference between the first and second terrain classifications to at least one health threshold. |
| FILED | Wednesday, April 27, 2022 |
| APPL NO | 17/730486 |
| CURRENT CPC | Time or Attendance Registers; Registering or Indicating the Working of Machines; Generating Random Numbers; Voting or Lottery Apparatus; Arrangements, Systems or Apparatus for Checking Not Provided for Elsewhere G07C 5/02 (20130101) Original (OR) Class G07C 5/008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220343917 | TANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhenyu TANG (Greenbelt, Maryland); Dinesh MANOCHA (Bethesda, Maryland) |
| ABSTRACT | Methods and systems for far-field speech recognition are disclosed. The methods and systems include receiving multiple noisy speech samples at a target scene; generating multiple labeled vectors and multiple intermediate samples based on the multiple labeled vectors; and determining multiple pair-wise distances between each intermediate sample and each vector of a full set of acoustic impulse responses (AIRs). In some instances, such methods may further include selecting a subset of the full set of AIRs based on the multiple pair-wise distances; and training a deep learning model based on the subset of the full set of AIRs. In other instances, such methods may further include obtaining a deep-learning model trained with a dataset having similar acoustic characteristics to the noisy speech samples; and performing speech recognition of the noisy speech samples based on the trained deep-learning model. Other aspects, embodiments, and features are also claimed and described. |
| FILED | Monday, April 18, 2022 |
| APPL NO | 17/723339 |
| CURRENT CPC | Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 15/16 (20130101) G10L 15/32 (20130101) Original (OR) Class G10L 15/063 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220344902 | Jacobs et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Intraband LLC (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven A. Jacobs (Madison, Wisconsin); Robert A. Marsland (Madison, Wisconsin) |
| ABSTRACT | A semiconductor laser including a waveguide having a core, a confinement layer to bury the core, and a metallization layer. The core includes an active core region. The confinement layer surrounds the core and includes a first confinement layer between the core and the semiconductor substrate below the core, a second confinement layer above the core, and a third confinement layer to either or both sides of the core. The metallization layer is located above the confinement layers and include a first metallization layer and a second metallization layer. The first metallization layer is in direct contact with the second confinement layer and the third confinement layer, while the second metallization layer is disposed above the first layer. The first metallization layer is tuned to have a plasmon resonance corresponding to a higher order mode with high loss. |
| FILED | Friday, April 22, 2022 |
| APPL NO | 17/727018 |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/0653 (20130101) Original (OR) Class H01S 5/2206 (20130101) H01S 5/3402 (20130101) H01S 5/34313 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220345154 | Sample |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | John T. Sample (Pearl River, Louisiana) |
| ABSTRACT | Systems and methods are provided for reducing error in data compression and decompression when data is transmitted over low bandwidth communication links, such as satellite links. Embodiments of the present disclosure provide systems and methods for variable block size compression for gridded data, efficiently storing null values in gridded data, and eliminating growth of error in compressed time series data. |
| FILED | Tuesday, July 12, 2022 |
| APPL NO | 17/863017 |
| CURRENT CPC | Electric Digital Data Processing G06F 11/076 (20130101) G06F 11/0709 (20130101) Coding; Decoding; Code Conversion in General H03M 7/6041 (20130101) Original (OR) Class Transmission H04B 7/185 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220345165 | Buckwalter et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James F. Buckwalter (Santa Barbara, California); Hussam Alshammary (Goleta, California) |
| ABSTRACT | A method for carrier aggregation receives a signal with multiple non-contiguous carrier bands. Frequency converting of the signal to a compressed single intermediate frequency band with a pseudonoise code applied to a local oscillation of each of the multiple non-contiguous carrier bands while maintaining separation of the multiple non-contiguous carrier bands permits reduced complexity digital signal processing to detect spectral power density and demodulate waveforms across multiple channels A receiver includes a pseudorandom noise generator applying a pseudo noise code to the local oscillator generator to produce a unique set of spectral tones in the output signal that sample-specific channels over the multiple non-contiguous carrier bands. |
| FILED | Thursday, September 03, 2020 |
| APPL NO | 17/640691 |
| CURRENT CPC | Transmission H04B 1/10 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 5/001 (20130101) H04L 5/0041 (20130101) H04L 27/0014 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220345340 | KIM et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hun-Seok KIM (Ann Arbor, Michigan); Chin-Wei HSU (Ann Arbor, Michigan); David T. BLAAUW (Ann Arbor, Michigan); Benjamin KEMPKE (Ann Arbor, Michigan) |
| ABSTRACT | When the ultra-low power mm-scale sensor node does not have a crystal oscillator and phase-lock loop, it inevitably exhibits significant carrier frequency offset (CFO) and sampling frequency offset (SFO) with respect to the reference frequencies in the gateway. This disclosure enables efficient real-time calculation of accurate SFO and CFO at the gateway, thus the ultra-low power mm-scale sensor node can be realized without a costly and bulky clock reference crystal and also power-hungry phase lock loop. In the proposed system, the crystal-less sensor starts transmission with repetitive RF pulses with a constant interval, followed by the data payload using pulse-position modulation (PPM). A proposed algorithm uses a two-dimensional (2D) fast Fourier transform (FFT) based process that identifies the SFO and CFO at the same time to establish successful wireless communication between the gateway and crystal-less sensor nodes. |
| FILED | Friday, January 29, 2021 |
| APPL NO | 17/162056 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 27/0014 (20130101) Original (OR) Class H04L 2027/0016 (20130101) H04L 2027/0018 (20130101) H04L 2027/0065 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20220338692 | Chichester et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David L. Chichester (Idaho Falls, Idaho); Alexander K. May (Idaho Falls, Idaho); Kevin P. Carney (Idaho Falls, Idaho) |
| ABSTRACT | A modular particle collection system includes a hollow lower member, a hollow upper member separably attached to the hollow lower member, a collection container separably attached to a longitudinal end of the hollow lower member opposite the hollow upper member, an inlet portion extending radially from the hollow lower member and configured to be fitted to a first portion of a vacuum system, a particulate filter, and an outlet portion extending radially outward from the hollow upper member and configured to be fitted to a second portion of vacuum system. Additional modular particle collection systems and a method of making a modular collection system are also disclosed. |
| FILED | Wednesday, April 20, 2022 |
| APPL NO | 17/659935 |
| CURRENT CPC | Domestic Washing or Cleaning; Suction Cleaners in General A47L 5/24 (20130101) A47L 9/104 (20130101) A47L 9/1625 (20130101) A47L 9/1666 (20130101) A47L 9/1683 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220339579 | Voskian et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Verdox, Inc (Woburn, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sahag Voskian (Boston, Massachusetts); Alexander Reath (Melrose, Massachusetts); Cameron Rogers (Malden, Massachusetts); Alexander Murray (Arlington, Massachusetts); Seokjoon Oh (Malden, Massachusetts) |
| ABSTRACT | A method for separating a Lewis acid gas from a fluid mixture, comprising contacting the fluid mixture with a reduced electroactive species; a non-aqueous electrolyte; and a stabilizing additive to form an anion adduct between the Lewis acid gas and the reduced electroactive species, wherein the electroactive species comprises an oxidized state, and at least one reduced state that bonds with the Lewis acid gas to form the anion adduct, wherein the stabilizing additive comprises a cationic Lewis acid, a hydrogen-bond donor, or a combination thereof, and the stabilizing additive is present in an effective amount to kinetically favor the forming of the anion adduct from the reduced electroactive species and thermodynamically favor the forming of the anion adduct in the thermodynamic equilibrium between the anion adduct and the reduced electroactive species. |
| FILED | Monday, February 07, 2022 |
| APPL NO | 17/665815 |
| CURRENT CPC | Separation B01D 53/326 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220339609 | HU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | WEST VIRGINIA UNIVERSITY (Morgantown, West Virginia); BATTELLE MEMORIAL INSTITUTE (Richland, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jianli HU (Morgantown, West Virginia); I-Wen WANG (Morgantown, West Virginia); Lili LI (Zhoukou, Henan, China PRC); Robert Alexander DAGLE (Richland, Washington); Juan A. LOPEZ-RUIZ (Richland, Washington); Mengze XU (Richland, Washington); Stephen deLemos DAVIDSON (Richland, Washington) |
| ABSTRACT | In one aspect, the disclosure relates to relates to CO2-free methods of co-producing hydrogen and solid forms of carbon via methane decomposition. The methods are efficient, self-sustaining, and environmentally sound. In a further aspect, the disclosure relates to recyclable and recoverable catalysts supported by solid forms of carbon and methods for recycling the catalysts. In some aspects, the disclosure relates to catalysts that do not require support by solid forms of carbon. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure. |
| FILED | Friday, October 30, 2020 |
| APPL NO | 17/772967 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/185 (20130101) B01J 23/892 (20130101) Original (OR) Class B01J 37/08 (20130101) Non-metallic Elements; Compounds Thereof; C01B 3/26 (20130101) C01B 3/50 (20130101) C01B 2203/1058 (20130101) C01B 2203/1064 (20130101) C01B 2203/1082 (20130101) C01B 2203/1241 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220339877 | MORAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bryan D. MORAN (Pleasanton, California); Brian J. BAUMAN (Pleasanton, California) |
| ABSTRACT | The present disclosure relates to a system for performing scanning projection stereolithography. The system uses a light projector which is configured to generate a polymerizing optical signal to initiate polymerization of a photopolymerizable resin or material at a build plane. An optics subsystem collimates and focuses the polymerizing optical signal. The optics subsystem is movable relative to the build plane to optimize focus of the polymerizing optical signal at the build plane. A light scanning subsystem directs the polymerizing optical signal received from the optics subsystem to selected X axis and Y axis locations on the build plane. A positioning subsystem positions the optics subsystem at a selected location relative to the build plane, where the selected location is chosen to optimize focusing of the polymerizing optical signal at a specific, selected X/Y location on the build plane. |
| FILED | Tuesday, April 26, 2022 |
| APPL NO | 17/729140 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/135 (20170801) B29C 64/268 (20170801) B29C 64/386 (20170801) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 50/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220339883 | MORAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California); 3D SYSTEMS, INC. (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bryan D. MORAN (Livermore, California); Brian J. BAUMAN (Livermore, California); Matthew Kenneth GELBER (Houston, Texas); Jordan MILLER (Houston, Texas) |
| ABSTRACT | Provided herein is a system for producing a product. The system generally comprises a large-area micro-stereolithography system, an optical imaging system, and a controller in communication with the large-area micro-stereolithography system and the optical imaging system. The large-area micro-stereolithography system is capable of generating the product by optically polymerizing successive layers of a curable resin at a build plane. The controller is capable of analyzing a focus level of the reference target based on the captured image; and based on the analyzing, adjusting a focus property of the projected image beam of the stereolithography system. |
| FILED | Tuesday, April 26, 2022 |
| APPL NO | 17/729077 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/124 (20170801) B29C 64/393 (20170801) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 50/02 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340429 | Yi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BATTELLE MEMORIAL INSTITUTE (Richland, Washington) |
| ASSIGNEE(S) | BATTELLE MEMORIAL INSTITUTE (Richland, Washington) |
| INVENTOR(S) | Ran Yi (Richland, Washington); Ji-Guang Zhang (Richland, Washington) |
| ABSTRACT | A method for etching materials in which organic solvents are added to the etching mixture and combined in a mixing arrangement. When agitated organic materials mix with the etching agent and interact with the underlying material to form a shield around the etched areas that prevents the additional interaction of water with the newly etched areas and enables the etching of silicon oxides (SiOx) but does not oxidize Si. This method leads to milder reactions with less heat generation and avoids the safety hazards associated with conventional etching methods. |
| FILED | Tuesday, April 27, 2021 |
| APPL NO | 17/241743 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 33/023 (20130101) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2004/61 (20130101) Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials C03C 15/00 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 13/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340438 | Paranthaman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | M. Parans Paranthaman (Knoxville, Tennessee); Bruce A. Moyer (Oak Ridge, Tennessee); Tej Nath Lamichhane (Melrose, Massachusetts) |
| ABSTRACT | A method of selectively extracting lithium from a lithium sulfate aqueous solution, the method comprising: (i) mixing an aluminum-containing sorbent material into the lithium sulfate aqueous solution to form a precursor mixture, wherein the aluminum-containing sorbent material is an aluminum hydroxide, aluminum oxide, or combination thereof; and (ii) heating the precursor mixture to a temperature of 50-200° C. to result in selective formation of a solid lithium-aluminum complex and mother liquor; and wherein the method may further comprise: (iii) recovering isolated lithium salt from the solid lithium-aluminum complex by heating the solid lithium-aluminum complex in water or aqueous solution at a temperature of 50-100° C. to result in delithiation of the solid lithium-aluminum complex with transfer of the lithium salt from the solid lithium-aluminum complex to the water or aqueous solution, along with production of aluminum hydroxide solid. |
| FILED | Thursday, April 21, 2022 |
| APPL NO | 17/725902 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/08 (20130101) Compounds of Alkali Metals, i.e Lithium, Sodium, Potassium, Rubidium, Caesium, or Francium C01D 15/02 (20130101) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/72 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340706 | Anthamatten |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Rochester (Rochester, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mitchell Anthamatten (Rochester, New York) |
| ABSTRACT | A shape-memory polymer that is melt-recyclable with high processability and little performance loss, in contrast to known Crosslinked semicrystalline shape-memory networks that are capable of storing large amounts of elastic energy with negligible plastic deformation but as thermosets are not easily melt-processed or recycled. In examples herein, catalyst-free isocyanate chemistry is used to prepare two linear poly(caprolactone)s with bisurea hydrogen bonding groups periodically positioned along the main chain. Compared to an entangled poly(caprolactone) homopolymer of similar molecular weight, the segmented poly(bisurea)s exhibit minimal stress relaxation when elastically strained at identical conditions. Furthermore, the materials' single relaxation times indicate chain reptation, and at sufficient temperatures, disentanglement occurs rapidly enough to perform melt-processing. The polymers show excellent shape fixity and recovery before and after shredding, melt-pressing, and annealing into a reprocessed film. |
| FILED | Thursday, February 24, 2022 |
| APPL NO | 17/679806 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340731 | Xu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Ting Xu (Berkeley, California); Christopher DelRe (Berkeley, California); Junpyo Kwon (Berkeley, California) |
| ABSTRACT | Nanoscopic dispersion of trace enzymes and random heteropolymers in plastics provides to fully functional plastics with eco-friendly microplastic elimination and programmable degradation. |
| FILED | Sunday, June 19, 2022 |
| APPL NO | 17/844026 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 11/105 (20130101) Original (OR) Class C08J 2367/04 (20130101) Compositions of Macromolecular Compounds C08L 67/04 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 17/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340937 | Kramer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert A. Kramer (Crown Point, Indiana); Libbie S.W. Pelter (Schererville, Indiana); John A. Patterson (West Lafayette, Indiana) |
| ABSTRACT | Processes and systems for biologically producing hydrogen gas from organic waste, including food waste. Such a process includes biologically producing hydrogen gas from organic waste by anaerobic fermentation of the organic waste with at least one strain of yeast. |
| FILED | Friday, September 25, 2020 |
| APPL NO | 17/763761 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/18 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 3/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340987 | Huang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shenyan Huang (Niskayuna, New York); Min Zou (Niskayuna, New York); Steve John Buresh (Latham, New York); Wanming Zhang (Clifton Park, New York); Pazhayannur Ramanathan Subramanian (Clifton Park, New York) |
| ABSTRACT | Methods for forming a dual-phase magnetic component from an initial component comprising a non-magnetic austenite composition are provided. The method may include: forming a coating on a portion of the surface of the initial component to form a masked area while leaving an unmasked area thereon. Thereafter the initial component may be heated to a treatment temperature such that nitrogen diffuses out of the unmasked area of the initial component to transform the non-magnetic austenite composition to a magnetic phase in the unmasked area. Thereafter, the initial component may be cooled from the treatment temperature to form a dual-phase magnetic component having a magnetic region corresponding to the unmasked area and a non-magnetic region corresponding to the masked area. |
| FILED | Wednesday, April 21, 2021 |
| APPL NO | 17/236322 |
| CURRENT CPC | Modifying the Physical Structure of Ferrous Metals; General Devices for Heat Treatment of Ferrous or Non-ferrous Metals or Alloys; Making Metal Malleable, e.g by Decarburisation or Tempering C21D 3/08 (20130101) Original (OR) Class C21D 2211/001 (20130101) Dynamo-electric Machines H02K 15/02 (20130101) H02K 15/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340997 | ZIEMKIEWICZ et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | West Virginia University (Morgantown, West Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul F. ZIEMKIEWICZ (Morgantown, West Virginia); James CONSTANT (Foster, West Virginia); David K. HOFFMAN, JR. (Waltersburg, Pennsylvania); John D. QUARANTA (Morgantown, West Virginia) |
| ABSTRACT | The present disclosure relates to processes for treating a coal associated material, e.g., acid mine drainage, while simultaneously recovering a high-grade rare earth preconcentrate suitable for extraction of commercially valuable rare earth oxides. Disclosed herein are methods for preparing a hydraulic pre-concentrate enriched in rare earth elements and critical minerals. Also disclosed herein are methods for preparing a pregnant leach solution from the disclosed hydraulic pre-concentrates. The present disclosure also relates to systems and plants for carrying out the disclosed processes. Also disclosed are compositions produced by the process disclosed herein in which the compositions comprise rare earth elements. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure. |
| FILED | Monday, March 28, 2022 |
| APPL NO | 17/706584 |
| CURRENT CPC | Production and Refining of Metals; Pretreatment of Raw Materials C22B 3/20 (20130101) C22B 3/065 (20130101) Original (OR) Class C22B 59/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220341006 | LUO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aihua LUO (Westerville, Ohio); Renhai SHI (Beijing, China PRC) |
| ABSTRACT | Disclosed herein are magnesium alloys and methods of making and use thereof. The magnesium alloys comprise: from 1 to 1.5 wt % Zn, from 1 to 1.4 wt. % Al, from 0.2 to 0.7 wt % Ca, from 0.2 to 0.4 wt % Ce, from 0.1 to 0.8 wt % Mn, and the balance comprising Mg. |
| FILED | Monday, September 28, 2020 |
| APPL NO | 17/764389 |
| CURRENT CPC | Alloys C22C 23/00 (20130101) C22C 23/02 (20130101) C22C 23/04 (20130101) Original (OR) Class Changing the Physical Structure of Non-ferrous Metals and Non-ferrous Alloys C22F 1/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220341582 | Baerga |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | EATON INTELLIGENT POWER LIMITED (Dublin, Ireland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeremy M. Santiago Baerga (Southfield, Michigan) |
| ABSTRACT | A luminaire includes a core made up of a first material and an LED lighting arrangement mounted to the core. The luminaire further includes a housing made up of a second material. The second material is different from the first material. The housing including a recess in which the core is received. The housing further includes a finned part. |
| FILED | Thursday, April 21, 2022 |
| APPL NO | 17/726054 |
| CURRENT CPC | Non-electric Light Sources Using Luminescence; Light Sources Using Electrochemiluminescence; Light Sources Using Charges of Combustible Material; Light Sources Using Semiconductor Devices as Light-generating Elements; Light Sources Not Otherwise Provided for F21K 9/90 (20130101) Functional Features or Details of Lighting Devices or Systems Thereof; Structural Combinations of Lighting Devices With Other Articles, Not Otherwise Provided for F21V 29/87 (20150115) Original (OR) Class F21V 29/777 (20150115) Indexing Scheme Associated With Subclasses F21K, F21L, F21S and F21V, Relating to the Form or the Kind of the Light Sources or of the Colour of the Light Emitted F21Y 2115/10 (20160801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220341849 | Doughty et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin L. Doughty (Knoxville, Tennessee); Yingzhong Ma (Oak Ridge, Tennessee); Uvinduni Premadasa (Oak Ridge, Tennessee) |
| ABSTRACT | A system for multimodal nonlinear optical imaging is provided. Each mode uses a high NA objective to cause total internal reflection excitation at a sample-substrate interface. The system has a femtosecond oscillator to generate pulses used for two beams. The objective receives at least one beam, redirects the received at least one beam through a dielectric substrate to cause the TIR and produces corresponding evanescent waves in a portion of the sample adjacent to the sample-substrate interface, and collects a backward-propagating beam of pulses of responsive light. The portion of the sample illuminated by the evanescent waves emits responsive light. Different modes or combinations of the distinct modalities may be selected to access complementary chemical and structural information for various chemical species near the sample-substrate interface. Each mode may have mode-specific control such as selective beam blocking, power ratios and filtering. |
| FILED | Friday, April 22, 2022 |
| APPL NO | 17/726906 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/65 (20130101) G01N 21/552 (20130101) G01N 21/648 (20130101) Original (OR) Class G01N 2021/653 (20130101) G01N 2201/06113 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/3532 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/0057 (20130101) H01S 3/0092 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220341861 | Chen |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Texas Tech University System (Lubbock, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chau-Chyun Chen (Lubbock, Texas) |
| ABSTRACT | The present invention includes a method for thermodynamic formulation of a Langmuir isotherm comprising: (1), (1′) (1), (1′) where ni is the adsorption amount of gas component i; (1′) is the adsorption maximum amount; P is the gas vapor pressure, and K is the apparent adsorption equilibrium constant in which adsorption and desorption rates are proportional to a concentrations of vacant sites and occupied sites; and substituting the concentration of both a vacant site and an occupied site with site activities, wherein a reference state for the vacant sites is at zero surface coverage while the reference state for the occupied sites is at full surface coverage. |
| FILED | Monday, August 10, 2020 |
| APPL NO | 17/616287 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 25/4806 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220341902 | Lu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Department of Energy (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fei Lu (Lubbock, Texas); Ruishu Feng Wright (Pittsburgh, None); Paul R. Ohodnicki, JR. (Allison Park, Pennsylvania); Ping Lu (West Hartford, Connecticut) |
| ABSTRACT | A system for determining pH of a fluid and a method to determine the pH of a fluid contacting a sensor, the method having the steps of: providing the sensor to an environment such that the sensor is in contact with the fluid, wherein the sensor features a fiber extending between a first end and a second end along a longitudinal axis, wherein the fiber further features a medial portion positioned between the first and second ends, wherein the sensor further features a pH sensitive coating on the medial portion of the fiber, and wherein the pH sensitive material features a metal oxide including but not limited to SiO2, TiO2, ZrO2, Ta2O5, A2O3, and combinations thereof; interrogating the sensor with an optical signal; collecting a modified optical signal after the sensor has been interrogated; and determining the pH of the fluid contacting the pH sensor using the modified optical signal. |
| FILED | Tuesday, April 26, 2022 |
| APPL NO | 17/729511 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 33/12 (20130101) Compounds of the Metals Beryllium, Magnesium, Aluminium, Calcium, Strontium, Barium, Radium, Thorium, or of the Rare-earth Metals C01F 7/02 (20130101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 23/047 (20130101) C01G 25/02 (20130101) C01G 35/00 (20130101) Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 11/025 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/80 (20130101) G01N 31/22 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220342225 | Rushford et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael C. Rushford (Livermore, California); Brian Bauman (Livermore, California); Tiziana C. Bond (Livermore, California); Matthew Medd Roberts (Livermore, California) |
| ABSTRACT | In various implementations, a sample cell for optical analysis can include a housing configured to confine a sample to be analyzed. The cell can include at least one planar reflector and at least one concave reflector. The at least one planar reflector can be disposed in the housing to receive light from a light source. The at least one concave reflector can be disposed in the housing with respect to the at least one planar reflector to receive light reflected from the at least one planar reflector and to reflect at least of portion of the light back to the at least one planar reflector. The at least one planar reflector can be configured to reflect at least a portion of the light away from said at least one planar reflector to be analyzed. |
| FILED | Tuesday, April 26, 2022 |
| APPL NO | 17/730092 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 27/0983 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220342761 | HUKERIKAR et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NVIDIA CORPORATION (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Saurabh HUKERIKAR (Santa Clara, California); Nirmal Raj SAXENA (Los Altos Hills, California) |
| ABSTRACT | In various embodiments, a software program uses hardware features of a parallel processor to checkpoint a context associated with an execution of a software application on the parallel processor. The software program uses a preemption feature of the parallel processor to cause the parallel processor to stop executing instructions in accordance with the context. The software program then causes the parallel processor to collect state data associated with the context. After generating a checkpoint based on the state data, the software program causes the parallel processor to resume executing instructions in accordance with the context. |
| FILED | Thursday, April 22, 2021 |
| APPL NO | 17/237376 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/3861 (20130101) G06F 9/30101 (20130101) G06F 11/0772 (20130101) G06F 11/1407 (20130101) Original (OR) Class G06F 11/1438 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220343126 | Swager et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Timothy Manning Swager (Newton, Massachusetts); Joseph Michael Azzarelli (Cambridge, Massachusetts); Rong Zhu (Waltham, Massachusetts) |
| ABSTRACT | A wireless sensor platform design and a single walled carbon nanotube/ionic liquid-based chemidosimeter system can incorporated into a highly sensitive and selective chemical hazard badge that can dosimetrically detect an analyte down to a sub parts-per-million concentration. |
| FILED | Wednesday, December 01, 2021 |
| APPL NO | 17/539803 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/082 (20130101) A61B 5/4845 (20130101) A61B 2562/029 (20130101) A61B 2562/0285 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/122 (20130101) G01N 27/127 (20130101) G01N 27/4146 (20130101) G01N 33/0057 (20130101) G01N 33/0075 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 19/0717 (20130101) Original (OR) Class Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 50/265 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220344067 | Ales et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BWXT Nuclear Energy, Inc. (Lynchburg, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew W. Ales (Puyallup, Washington); Emily D. Fleming (Forest, Virginia); Ted L. Thome (Cuyahoga Falls, Ohio) |
| ABSTRACT | An aft plenum assembly for use with a nuclear thermal reactor including a pressure vessel and a nozzle assembly having a top plenum plate disposed within the pressure vessel, the top plenum plate defining a first plurality of fuel flow apertures, a bottom plenum plate disposed within the pressure vessel, the bottom plenum plate being parallel to the top plenum plate thereby defining a plenum space therebetween, the bottom plenum plate defining a second plurality of fuel flow apertures, and a plurality of tubular connections extending between the first plurality of fuel flow apertures of the top plenum plate and the second plurality of fuel flow apertures of the bottom plenum plate, wherein the aft plenum assembly is disposed between the pressure vessel and the nozzle assembly. |
| FILED | Wednesday, April 27, 2022 |
| APPL NO | 17/731003 |
| CURRENT CPC | Nuclear Reactors G21C 1/322 (20130101) G21C 1/324 (20130101) G21C 15/253 (20130101) Original (OR) Class Nuclear Power Plant G21D 5/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220344106 | YU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona); The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhengshan YU (Gilbert, Arizona); Zachary HOLMAN (Phoenix, Arizona); Bo CHEN (Chapel Hill, North Carolina); Jinsong HUANG (Chapel Hill, North Carolina) |
| ABSTRACT | A tandem photovoltaic device includes a silicon photovoltaic cell having a silicon layer, a perovskite photovoltaic cell having a perovskite layer, and an intermediate layer between a rear side of the perovskite photovoltaic cell and a front (sunward) side of the silicon photovoltaic cell. The front side of the silicon layer has a textured surface, with a peak-to-valley height of structures in the textured surface of less than 1 μm or less than 2 μm. The textured surface is planarized by the intermediate layer or a layer of the perovskite photovoltaic cell. Forming the tandem photovoltaic device includes texturing a silicon containing layer of a silicon photovoltaic cell and operatively coupling a perovskite photovoltaic cell comprising a perovskite layer to the silicon photovoltaic cell, thereby forming a tandem photovoltaic device and planarizing the textured surface of the silicon containing layer of the silicon photovoltaic cell. |
| FILED | Wednesday, August 12, 2020 |
| APPL NO | 17/634788 |
| CURRENT CPC | Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 9/0036 (20130101) H01G 9/2009 (20130101) H01G 9/2072 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/286 (20130101) H01L 27/302 (20130101) H01L 31/028 (20130101) H01L 31/1804 (20130101) H01L 31/02363 (20130101) H01L 51/448 (20130101) H01L 51/4253 (20130101) H01L 51/4293 (20130101) H01L 2031/0344 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220344138 | Fedorov et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrei G. Fedorov (Atlanta, Georgia); Peter Arthur Kottke (Atlanta, Georgia) |
| ABSTRACT | Disclosed herein are specimen imaging systems, comprising: a sample stage in a vacuum environment, the sample stage configured to support a specimen; an electron beam generator configured to focus an electron beam on a first predetermined location on the specimen; a nanospray dispenser configured to dispense a nanospray onto a second predetermined location on the specimen; a mass spectrometer; and an extraction conduit configured to extract a plume of charged particles generated as a result of contact between the nanospray and the specimen and deliver the charged particles to the mass spectrometer. The system can create a topological and chemical map of the specimen by analyzing at least a portion of the specimen with a mass spectrometer to determine a chemical composition of the specimen at the second predetermined location and analyzing at least a portion of the specimen with the electron beam to determine a surface topology. |
| FILED | Friday, October 02, 2020 |
| APPL NO | 17/763294 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 37/20 (20130101) H01J 37/26 (20130101) H01J 49/0004 (20130101) Original (OR) Class H01J 49/147 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220344665 | Hersam et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark C. Hersam (Wilmette, Illinois); Norman S. Luu (Chicago, Illinois); Jin-Myoung Lim (Coppell, Texas) |
| ABSTRACT | A composite material and a method for fabricating the same. The composite material includes graphene and active material particles. Each surface of the active material particles is conformally coated with said graphene. The method includes forming a mixture containing an active material, graphene, ethyl cellulose (EC) polymer and multiwalled carbon nanotubes, and thermally annealing the mixture at an annealing temperature in an oxidizing environment to decompose the majority of EC, thereby resulting in the composite material having each active material particle coated with a conformal graphene coating. |
| FILED | Tuesday, April 05, 2022 |
| APPL NO | 17/713373 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/364 (20130101) H01M 4/525 (20130101) H01M 4/583 (20130101) H01M 4/622 (20130101) H01M 4/625 (20130101) Original (OR) Class H01M 10/0525 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220344700 | XIAO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GM GLOBAL TECHNOLOGY OPERATIONS LLC (Detroit, Michigan) |
| ASSIGNEE(S) | GM GLOBAL TECHNOLOGY OPERATIONS LLC (Detroit, Michigan) |
| INVENTOR(S) | Xingcheng XIAO (Troy, Michigan); Mengyuan CHEN (Madison Heights, Michigan) |
| ABSTRACT | The present disclosure provides a method for forming an ionically conductive polymer composite interlayer. The method may include forming a precursor layer between a first surface of an electroactive material layer and a first surface of a solid-state electrolyte layer and converting the precursor layer to the ionically conductive polymer composite interlayer. The at least one of the electroactive material layer or solid-state electrolyte may include lithium. The first surface of the electroactive material layer and the first surface of the solid-state electrolyte layer may be substantially parallel. The precursor layer may include one or more fluoropolymers comprising carbon and fluorine. The ionically conductive polymer composite layer may have an ionic conductivity greater than or equal to about 1.0×10−8 S·cm−1 to less than or equal to about 1.0 S·cm−1 and may include a lithium fluoride embedded in a carbonaceous matrix. |
| FILED | Wednesday, April 14, 2021 |
| APPL NO | 17/230788 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/362 (20130101) H01M 4/382 (20130101) H01M 4/0471 (20130101) H01M 4/583 (20130101) H01M 4/623 (20130101) H01M 10/0562 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220344737 | Belharouak et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ilias Belharouak (Oak Ridge, Tennessee); Yaocai Bai (Oak Ridge, Tennessee) |
| ABSTRACT | A method of recycling lithium-ion battery materials is provided. The method includes isolating a composite electrode that includes an electrode material adhered to a current collector. The composite electrode is combined with an aqueous buffer solution to form a mixture. The electrode material is delaminated from the current collector in the mixture to give a free electrode material and a free current collector. Each of the free electrode material and the free current collector is recovered from the mixture. Combining the composite electrode with the aqueous buffer solution occurs before delaminating the electrode material from the current collector. The step of delaminating optionally may include adding a surfactant to the mixture. |
| FILED | Tuesday, March 29, 2022 |
| APPL NO | 17/706981 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/54 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220344775 | Carlson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | LG Energy Solution, Ltd. (Seoul, South Korea) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven A. Carlson (Cambridge, Massachusetts); Benjamin Sloan (Exeter, New Hampshire); David W. Avison (Boxborough, Massachusetts) |
| ABSTRACT | Provided is a lithium battery, wherein the battery comprises an anode, a cathode, wherein the cathode comprises one or more transition metals, an electrolyte, and a porous separator interposed between the cathode and anode, wherein the separator comprises an anionic compound. Also provided are methods of manufacturing such batteries. |
| FILED | Friday, June 03, 2022 |
| APPL NO | 17/831964 |
| CURRENT CPC | Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/20 (20130101) H01G 11/50 (20130101) H01G 11/52 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/505 (20130101) H01M 10/052 (20130101) H01M 10/0525 (20130101) H01M 10/0585 (20130101) H01M 50/46 (20210101) H01M 50/446 (20210101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220344886 | Galvanauskas et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Almantas Galvanauskas (Ann Arbor, Michigan); Theodore Mathew Whittlesey (St. Clair, Michigan) |
| ABSTRACT | A laser system includes a signal source configured to generate input pulses, a diffraction grating module configured to stretch and split the input pulses into a plurality of spectral channels, a set of phase control devices, each phase control device being configured for spectral phase control of a respective spectral channel of the plurality of spectral channels, a power amplifier array of amplifier modules, each amplifier module of the power amplifier array being configured to amplify a respective spectral channel of the plurality of spectral channels, a spectral combiner configured to spectrally combine the plurality of spectral channels via diffraction grating-based pulse compression, and a feedback controller coupled to the spectral combiner to provide feedback to the set of phase control devices for pulse shaping. |
| FILED | Tuesday, October 06, 2020 |
| APPL NO | 17/765787 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 27/1086 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/0057 (20130101) Original (OR) Class H01S 3/1307 (20130101) H01S 3/06754 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20220338497 | CHU |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cross Cultured Foods PBC (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nathaniel CHU (Berkeley, California) |
| ABSTRACT | Cultured plant-based cheese compositions are formed from a plant-based emulsion made from legume material, seed material, or a combination thereof; coagulated into curds using a coagulating agent; and combined with one or more microbial cultures and proteolytic enzymes, which serve to develop flavor and texture during aging. Whey is then driven from the curds using a mechanical process to exert pressure on the curds. The cultured plant-based cheese composition may further include plant fats; sugars that serve to support the growth and fermentation of the microbial cultures; other ingredients that contribute to flavor development such as citrate or citric acid; or any combination thereof. Further flavor development occurs during aging, where the curds are maintained at temperatures of 0-16° C. for up to two years or more. In preferred variations, the cultured plant-based cheese composition does not comprise nuts. |
| FILED | Thursday, April 21, 2022 |
| APPL NO | 17/726446 |
| CURRENT CPC | Dairy Products, e.g Milk, Butter, Cheese; Milk or Cheese Substitutes; Making Thereof A23C 20/025 (20130101) Original (OR) Class A23C 2220/20 (20130101) Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 29/06 (20160801) A23L 29/065 (20160801) A23L 29/206 (20160801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220338734 | Hu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University Of Maryland, Baltimore (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fu-Ming Hu (Ellicott City, Maryland); Lynn G. Stansbury (Seattle, Washington); Colin F. Mackenzie (Pasadena, Maryland); Thomas M. Scalea (Baltimore, Maryland); Deborah M. Stein (Owings Mills, Maryland); Shiming Yang (Halethorpe, Maryland) |
| ABSTRACT | A method and apparatus for monitoring collection of subject condition data is provided. The method includes receiving a value of a parameter of subject condition data and a value of a sample time, for each of a plurality of sample times. The method also includes storing the subject condition data in a data structure including a first field for holding data indicating a current sample time and a second field for holding data indicating the value of the parameter. The method also includes determining a time gap defined by a duration between the current sample time and a most recent sample time and determining whether the time gap exceeds a time gap threshold and causing an apparatus to perform remedial action. A method for presenting the subject condition data on a display is also provided. |
| FILED | Monday, February 21, 2022 |
| APPL NO | 17/676657 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0006 (20130101) A61B 5/0008 (20130101) A61B 5/0022 (20130101) Original (OR) Class A61B 5/1113 (20130101) A61B 5/02055 (20130101) A61B 5/02405 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/40 (20180101) G16H 10/60 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220339017 | Shih et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Albert J. Shih (Ann Arbor, Michigan); Robert Chisena (Ann Arbor, Michigan); Ryan Posh (Ann Arbor, Michigan); Miguel Funes (Ann Arbor, Michigan); Darren Bolger (Ann Arbor, Michigan); Jeff Wensman (Ann Arbor, Michigan) |
| ABSTRACT | An additively manufactured ankle-foot orthosis. The ankle-foot orthosis includes an additively manufactured footplate and a calf cuff separate from the additively manufactured footplate. A pre-fabricated strut connects the additively manufactured footplate to the additively manufactured calf cuff and includes thickness and width adapted to define a patient-specific stiffness about an ankle joint of a patient. The stiffness of the pre-fabricated strut is suited to one or more of a gait need or a gait requirement of each patient, and the additively manufactured footplate has a portion with a shape complementary to a shape of a portion of the pre-fabricated strut. So configured, a collective shape and volume of the additively manufactured footplate and the pre-fabricated strut together are adapted to fit inside a shoe of the patient. |
| FILED | Thursday, September 17, 2020 |
| APPL NO | 17/761914 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 5/0111 (20130101) Original (OR) Class Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/393 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 50/02 (20141201) B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340177 | Khayatian et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents on Behalf of Arizona State University (Tempe, Arizona) |
| ASSIGNEE(S) | National Taiwan University (Taipei City, Taiwan) |
| INVENTOR(S) | Mohammad Khayatian (Tempe, Arizona); Mohammadreza Mehrabian (Tempe, Arizona); Harshith Allamsetti (Milpitas, California); Kai- Wei Liu (Taipei City, Taiwan); Po-Yu Huang (Taipei City, Taiwan); Chung-Wei Lin (Taipei City, Taiwan); Aviral Shrivastava (Phoenix, Arizona) |
| ABSTRACT | Various embodiments for systems and methods for cooperative driving of connected autonomous vehicles using responsibility-sensitive safety (RSS) rules are disclosed herein. The CAV system integrates proposed RSS rules with CAV's motion planning algorithm to enable cooperative driving of CAVs. The CAV system further integrates a deadlock detection and resolution system for resolving traffic deadlocks between CAVs. The CAV system reduces redundant calculation of dependency graphs. |
| FILED | Wednesday, March 16, 2022 |
| APPL NO | 17/696450 |
| CURRENT CPC | Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 30/18109 (20130101) B60W 60/00272 (20200201) Original (OR) Class B60W 60/00274 (20200201) B60W 2554/4041 (20200201) B60W 2554/4049 (20200201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340487 | Srubar, III et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | The Regents of the University of Colorado, a body cor (Denver, Colorado) |
| INVENTOR(S) | Wilfred V. Srubar, III (Boulder, Colorado); Juan Pablo Gevaudan (Austin, Texas) |
| ABSTRACT | Acid-resistant composite materials and methods of forming acid resistant composite materials are disclosed. The acid resistant composite materials can include one or more monovalent, divalent, or polyvalent cationic metals. The acid resistant composite materials can be used, for example, in the formation of concreate or as a coating for concrete. |
| FILED | Tuesday, August 11, 2020 |
| APPL NO | 17/635320 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 12/005 (20130101) Original (OR) Class C04B 2111/00215 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340494 | Singh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Kansas State University Research Foundation (Manhattan, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gurpreet Singh (Manhattan, Kansas); Zhongkan Ren (Manhattan, Kansas) |
| ABSTRACT | Ceramic matrix composite (CMC) materials are a desired solution for lightweight and high temperature applications. CMC materials can be reinforced with polymer-derived ceramic (PDC) fibers, which advantageously possess intrinsic thermal stability and high mechanical strength. Carbon-rich SiOC and SiOCN fibers were synthesized via hand-drawing and electrospinning polymer pyrolysis of a hybrid precursor materials with the aid of a spinning reagent. The prepared fibers are crosslinked and pyrolyzed for polymer-to-ceramic conversion. |
| FILED | Thursday, September 10, 2020 |
| APPL NO | 17/642326 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/64 (20130101) C04B 35/5603 (20130101) Original (OR) Class C04B 35/62281 (20130101) C04B 2235/483 (20130101) C04B 2235/5244 (20130101) C04B 2235/5248 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 1/02 (20130101) D01F 6/94 (20130101) D01F 11/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340612 | Guo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhongwu Guo (Gainesville, Florida); Qingjiang Li (Gainesville, Florida) |
| ABSTRACT | Provided are methods of synthesizing glycolipids. The methods combine chemical and enzymatic transformations to rapidly provide diverse natural and functionalized glycolipids in a high convergent matter. Stepwise enzymatic elongation of a carbohydrate chain of a common glycolipid precursor, compound (1), provides glycan intermediates of Formula (II), using sugar-nucleotides as glycosyl donors and glycosyltransferases as enzymes. Also provided are glycan intermediates of Formula (II) and alkene intermediates of Formula (IV) and methods of preparing same. |
| FILED | Thursday, September 17, 2020 |
| APPL NO | 17/761109 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 15/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340706 | Anthamatten |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Rochester (Rochester, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mitchell Anthamatten (Rochester, New York) |
| ABSTRACT | A shape-memory polymer that is melt-recyclable with high processability and little performance loss, in contrast to known Crosslinked semicrystalline shape-memory networks that are capable of storing large amounts of elastic energy with negligible plastic deformation but as thermosets are not easily melt-processed or recycled. In examples herein, catalyst-free isocyanate chemistry is used to prepare two linear poly(caprolactone)s with bisurea hydrogen bonding groups periodically positioned along the main chain. Compared to an entangled poly(caprolactone) homopolymer of similar molecular weight, the segmented poly(bisurea)s exhibit minimal stress relaxation when elastically strained at identical conditions. Furthermore, the materials' single relaxation times indicate chain reptation, and at sufficient temperatures, disentanglement occurs rapidly enough to perform melt-processing. The polymers show excellent shape fixity and recovery before and after shredding, melt-pressing, and annealing into a reprocessed film. |
| FILED | Thursday, February 24, 2022 |
| APPL NO | 17/679806 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
20220340726 — GAS PERMEABLE, ULTRATHIN, STRETCHABLE EPIDERMAL ELECTRONIC DEVICES AND RELATED METHODS
| US 20220340726 | Zhu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yong Zhu (Apex, North Carolina); Weixin Zhou (Nanjing, China PRC); Shanshan Yao (Coram, New York) |
| ABSTRACT | Presented herein are gas permeable, ultrathin, stretchable epidermal electronic devices and related methods enabled by self-assembled porous substrates and conductive nanostructures. Efficient and scalable breath figure method is employed to introduce the porous skeleton and then silver nanowires (AgNWs) are dip-coated and heat-pressed to offer electric conductivity. The resulting film has a transmittance of 61%, sheet resistance of 7.3 Ω/sq, and water vapor permeability of 23 mg cm−2 h−1. With AgNWs embedded below the surface of the polymer, the electrode exhibits excellent stability with the presence of sweat and after long-term wear. The present subject matter demonstrates the potential of the electrode for wearable applications—skin-mountable biopotential sensing for healthcare and textile-integrated touch sensing for human-machine interfaces. The electrode can form conformal contact with human skin, leading to low skin-electrode impedance and high-quality biopotential signals. In addition, the textile electrode can be used in a self-capacitance wireless touch sensing system. |
| FILED | Monday, April 25, 2022 |
| APPL NO | 17/728182 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/6802 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 7/0427 (20200101) Original (OR) Class Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/08 (20130101) Compositions of Macromolecular Compounds C08L 75/04 (20130101) Electric Digital Data Processing G06F 3/0416 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/02 (20130101) H01B 5/14 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/02603 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340850 | Kozbial |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | FLASKWORKS, LLC (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Kozbial (East Boston, Massachusetts) |
| ABSTRACT | A cell culture cartridge is provided comprising a plurality of zones geometrically configured to provide for symmetrical fluid flow with each of the plurality of zones to avoid dead areas in flow within each of the plurality of zones. In certain embodiments, at least eight inlets are provided, with an inlet positioned at each corner of the cell culture cartridge. In certain embodiments, a shared outlet is positioned on a top surface of the cell culture cartridge. |
| FILED | Wednesday, May 04, 2022 |
| APPL NO | 17/736467 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/20 (20130101) C12M 23/22 (20130101) C12M 23/34 (20130101) Original (OR) Class C12M 23/38 (20130101) C12M 25/14 (20130101) C12M 29/10 (20130101) C12M 41/00 (20130101) C12M 41/48 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0639 (20130101) C12N 2506/115 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220341540 | Andrews et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BRIGHAM YOUNG UNIVERSITY (Provo, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David W. Andrews (Provo, Utah); Spencer P. Magleby (Provo, Utah); Larry L. Howell (Orem, Utah) |
| ABSTRACT | An example deployable structure includes at least one base member, at least one first articulable member, at least one second articulable member, and at least one interference member. The deployable structure must include at least one base member, at least one first articulable member, at least one second articulable member, and at least one interference member otherwise the deployable structure may not be switchable between the compact and deployed states thereof. The base member is articulably connected to the first articulable member using a first hinge, the first articulable member is articulably connected to the second articulable member using a second hinge, and the interference member is articulably connected to the second articulable member using a third hinge. The interference member is also attached to the base member, for example, using a fourth hinge. The deployable structure is configured to switch from at least a compact state to a deployed state. |
| FILED | Thursday, April 21, 2022 |
| APPL NO | 17/726282 |
| CURRENT CPC | Frames, Casings or Beds of Engines, Machines or Apparatus, Not Specific to Engines, Machines or Apparatus Provided for Elsewhere; Stands; Supports F16M 13/022 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220341859 | Alexeenko et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Alina Alexeenko (West Lafayette, Indiana); Andrew Strongrich (Saginaw, Michigan) |
| ABSTRACT | A microelectromechanical (MEMS) gas sensor operating based on Knudsen thermal force is disclosed. The sensor includes a substrate, at least one stationary assembly that is fixedly coupled to the substrate, and at least one moveable assembly that is positioned above the substrate which is biased to move substantially according to a main axis and juxtaposed with the at least one stationary assembly. |
| FILED | Wednesday, December 26, 2018 |
| APPL NO | 16/233023 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 25/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220344138 | Fedorov et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrei G. Fedorov (Atlanta, Georgia); Peter Arthur Kottke (Atlanta, Georgia) |
| ABSTRACT | Disclosed herein are specimen imaging systems, comprising: a sample stage in a vacuum environment, the sample stage configured to support a specimen; an electron beam generator configured to focus an electron beam on a first predetermined location on the specimen; a nanospray dispenser configured to dispense a nanospray onto a second predetermined location on the specimen; a mass spectrometer; and an extraction conduit configured to extract a plume of charged particles generated as a result of contact between the nanospray and the specimen and deliver the charged particles to the mass spectrometer. The system can create a topological and chemical map of the specimen by analyzing at least a portion of the specimen with a mass spectrometer to determine a chemical composition of the specimen at the second predetermined location and analyzing at least a portion of the specimen with the electron beam to determine a surface topology. |
| FILED | Friday, October 02, 2020 |
| APPL NO | 17/763294 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 37/20 (20130101) H01J 37/26 (20130101) H01J 49/0004 (20130101) Original (OR) Class H01J 49/147 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220344539 | Reshchikov et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Virginia Commonwealth University (Richmond, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael A. Reshchikov (Henrico, Virginia); Denis O. Demchenko (Henrico, Virginia) |
| ABSTRACT | Exemplary devices such as ultraviolet light emitting diodes (UV LEDs) are disclosed which include conductive Be-doped p-type material with greatly improved efficiency over UV LEDs employing other dopants such as Mg. Exemplary processes for producing Be-doped p-type regions in semiconductor devices are also described. |
| FILED | Monday, April 25, 2022 |
| APPL NO | 17/660529 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 33/007 (20130101) H01L 33/0095 (20130101) H01L 33/325 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220344665 | Hersam et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark C. Hersam (Wilmette, Illinois); Norman S. Luu (Chicago, Illinois); Jin-Myoung Lim (Coppell, Texas) |
| ABSTRACT | A composite material and a method for fabricating the same. The composite material includes graphene and active material particles. Each surface of the active material particles is conformally coated with said graphene. The method includes forming a mixture containing an active material, graphene, ethyl cellulose (EC) polymer and multiwalled carbon nanotubes, and thermally annealing the mixture at an annealing temperature in an oxidizing environment to decompose the majority of EC, thereby resulting in the composite material having each active material particle coated with a conformal graphene coating. |
| FILED | Tuesday, April 05, 2022 |
| APPL NO | 17/713373 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/364 (20130101) H01M 4/525 (20130101) H01M 4/583 (20130101) H01M 4/622 (20130101) H01M 4/625 (20130101) Original (OR) Class H01M 10/0525 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220344826 | CHOWDHURY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kaushik CHOWDHURY (Needham, Massachusetts); Yousof NADERI (Brookline, Massachusetts); Ufuk MUNCUK (Waltham, Massachusetts) |
| ABSTRACT | Provided herein are systems and methods for implementing an over-the-air neural network (OANN) including by receiving, at a relay receiver of a relay node, a signal of interest from a transmitter, directionally re-transmitting the signal of interest from each of a plurality of relay transmitters of the relay node to a corresponding one of a plurality of programmable reconfigurable intelligent surfaces (RIS), reflecting, by each of the plurality of RIS, the corresponding re-transmitted signal of interest, and adjusting, by a neural network controller, a reflection angle of each of the plurality of RIS to direct the reflected signals of interest to combine in a deterministic manner at the relay receiver. |
| FILED | Friday, April 15, 2022 |
| APPL NO | 17/721409 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Antennas, i.e Radio Aerials H01Q 15/147 (20130101) Original (OR) Class H01Q 19/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220345076 | Nickerson |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Portable Solar Inc. (Pinecrest, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dennis Nickerson (Pinecrest, Florida) |
| ABSTRACT | A portable system for mounting a solar panel includes a modular base defining a set of interconnecting components that assemble via a set of intra-assembly features into a portable base for a solar panel. The modular base includes lower and upper relief to provide passive ventilation to the interior of the modular base and recesses to accommodate a user's appendages during assembly, and ballast volumes to retain a non-rigid ballast to weight the module base holding it in place. The modular base includes adjustable panel retention structures to constrain solar panels of a range of dimensions and configured to carry moisture away from the solar panel. The modular base includes a set of latches and corresponding latch receivers to fix adjacent modular bases together at a fixed distance less than the width of a human hand to form an array. |
| FILED | Tuesday, April 26, 2022 |
| APPL NO | 17/729362 |
| CURRENT CPC | Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 20/30 (20141201) Original (OR) Class H02S 40/34 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220345306 | Sahin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Drexel University (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cem Sahin (Philadelphia, Pennsylvania); Kapil R. Dandekar (Philadelphia, Pennsylvania) |
| ABSTRACT | Symmetric keys are generated by an algorithm that uses the randomness from the wireless PHY layer to extract the keys. When used with reconfigurable antennas, the algorithm yields longer keys. By using the randomness from the wireless PHY layer, the algorithm solves the issue of secure information leakage to the wireless channel during key establishment phase. The algorithm also omits transmitting anything secure during this phase and prevents any intruder from obtaining information related to the key. This approach can automatically secure the communications over open wireless networks (those without authentication or encryption) or closed wireless networks using other methods of authentication. |
| FILED | Thursday, April 14, 2022 |
| APPL NO | 17/720610 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/14 (20130101) H04L 9/0875 (20130101) Original (OR) Class H04L 2209/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20220338497 | CHU |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cross Cultured Foods PBC (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nathaniel CHU (Berkeley, California) |
| ABSTRACT | Cultured plant-based cheese compositions are formed from a plant-based emulsion made from legume material, seed material, or a combination thereof; coagulated into curds using a coagulating agent; and combined with one or more microbial cultures and proteolytic enzymes, which serve to develop flavor and texture during aging. Whey is then driven from the curds using a mechanical process to exert pressure on the curds. The cultured plant-based cheese composition may further include plant fats; sugars that serve to support the growth and fermentation of the microbial cultures; other ingredients that contribute to flavor development such as citrate or citric acid; or any combination thereof. Further flavor development occurs during aging, where the curds are maintained at temperatures of 0-16° C. for up to two years or more. In preferred variations, the cultured plant-based cheese composition does not comprise nuts. |
| FILED | Thursday, April 21, 2022 |
| APPL NO | 17/726446 |
| CURRENT CPC | Dairy Products, e.g Milk, Butter, Cheese; Milk or Cheese Substitutes; Making Thereof A23C 20/025 (20130101) Original (OR) Class A23C 2220/20 (20130101) Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 29/06 (20160801) A23L 29/065 (20160801) A23L 29/206 (20160801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340558 | Fuller et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alkermes, Inc. (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nathan Oliver Fuller (Arlington, Massachusetts); John A. Lowe, III (Stonington, Connecticut) |
| ABSTRACT | Provided herein are compounds and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of conditions associated with inhibition of HDAC (e.g., HDAC2). |
| FILED | Wednesday, December 22, 2021 |
| APPL NO | 17/558840 |
| CURRENT CPC | Heterocyclic Compounds C07D 471/04 (20130101) Original (OR) Class C07D 487/04 (20130101) C07D 513/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340560 | Fuller et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alkermes, Inc. (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nathan Oliver Fuller (Arlington, Massachusetts); John A. Lowe, III (Stonington, Connecticut) |
| ABSTRACT | Provided herein are compounds and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of conditions associated with inhibition of HDAC (e.g,. HDAC2). |
| FILED | Wednesday, December 22, 2021 |
| APPL NO | 17/559488 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/437 (20130101) A61K 31/519 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Heterocyclic Compounds C07D 471/04 (20130101) Original (OR) Class C07D 487/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220341826 | Adolphson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | INNOVAPREP LLC (Drexel, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alec D. Adolphson (Raymore, Missouri); Andrew E. Page (Smithton, Missouri); John D. Birkenholz (Kansas City, Missouri); David Goad (Stillwater, Oklahoma) |
| ABSTRACT | Devices, systems and methods are disclosed which relate to a prefiltration device that can be used with the concentrating pipette instruments and other devices which draw a sample in through one opening and dispense a concentrated or eluted sample out through the same opening. The device allows the sample to be passed through a prefilter when entering the opening and then bypassed the prefilter when being dispensed through the same opening. |
| FILED | Friday, April 22, 2022 |
| APPL NO | 17/726625 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502753 (20130101) B01L 2300/0681 (20130101) B01L 2300/0832 (20130101) B01L 2400/0683 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/34 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220344902 | Jacobs et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Intraband LLC (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven A. Jacobs (Madison, Wisconsin); Robert A. Marsland (Madison, Wisconsin) |
| ABSTRACT | A semiconductor laser including a waveguide having a core, a confinement layer to bury the core, and a metallization layer. The core includes an active core region. The confinement layer surrounds the core and includes a first confinement layer between the core and the semiconductor substrate below the core, a second confinement layer above the core, and a third confinement layer to either or both sides of the core. The metallization layer is located above the confinement layers and include a first metallization layer and a second metallization layer. The first metallization layer is in direct contact with the second confinement layer and the third confinement layer, while the second metallization layer is disposed above the first layer. The first metallization layer is tuned to have a plasmon resonance corresponding to a higher order mode with high loss. |
| FILED | Friday, April 22, 2022 |
| APPL NO | 17/727018 |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/0653 (20130101) Original (OR) Class H01S 5/2206 (20130101) H01S 5/3402 (20130101) H01S 5/34313 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20220338754 | LUCAS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | BRIAN P. LUCAS (Norwich, Vermont); GARRETT G. GRINDLE (Pittsburgh, Pennsylvania) |
| ABSTRACT | Devices and methods for standardizing breathing effort in subjects are disclosed. An exemplary device has an exhaust housing having a proximal portion that defines a port and an opposed distal portion that defines inspiration and expiration pathways. The distal portion has a distal end surface, and the inspiration and expiration pathways are in fluid communication with the port and extend, respectively, to inlet and outlet openings defined in the distal end surface. An airflow adjustment plate, which defines openings having varying sizes, is rotatably coupled to the distal portion of the exhaust housing. Rotation of the airflow adjustment plate relative to the exhaust housing among a plurality of rotational positions, with a respective opening of the airflow adjustment plate being positioned in alignment with the inlet opening at each position, thereby increasing or decreasing resistance to air flow through the inlet opening. |
| FILED | Friday, September 18, 2020 |
| APPL NO | 17/761321 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/08 (20130101) Original (OR) Class Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 16/208 (20130101) A61M 16/0866 (20140204) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220339136 | Cao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government As Represented By The Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Feng Cao (St. Louis, Missouri); Xinggou Cheng (San Antonio, Texas) |
| ABSTRACT | The present disclosure is concerned with liposomal formulations comprising troponoid compounds and methods of using same in the treatment of, for example, viral infections, antimicrobial infections, cancer, inflammatory diseases, and cardiovascular diseases. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| FILED | Friday, August 28, 2020 |
| APPL NO | 17/639265 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1271 (20130101) A61K 31/122 (20130101) A61K 31/185 (20130101) A61K 31/192 (20130101) A61K 31/235 (20130101) A61K 31/265 (20130101) Original (OR) Class A61K 31/355 (20130101) A61K 31/381 (20130101) A61K 31/546 (20130101) A61K 31/575 (20130101) A61K 31/7036 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220339457 | Arvanian et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIR (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Victor Arvanian (Northpoint, New York); Hayk Petrosyan (Northpoint, New York); Magda Fahmy (Northpoint, New York); Asrat Tesfa (Northpoint, New York); Joseph Fasano (Northpoint, New York) |
| ABSTRACT | Devices, systems, and methods for treating lower back pain (e.g., chronic lower back pain) with electromagnetic stimulation are disclosed. A device for treating lower back pain can have a seat portion, a backrest portion, and an electromagnetic stimulation coil operatively associated with the backrest portion. The electromagnetic stimulation coil can be positioned to apply electromagnetic stimulation to a spine of a patient while the patient is seated on the seat portion. |
| FILED | Friday, August 21, 2020 |
| APPL NO | 17/636627 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 2/02 (20130101) A61N 2/006 (20130101) A61N 2/008 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220340614 | Marx et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duke University (Durham, North Carolina); Department of Veterans Affairs (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christine Marx (Durham, North Carolina); Robert Mook (Durham, North Carolina) |
| ABSTRACT | The present disclosure provides modified neuroactive steroids. The modified neuroactive steroids may comprise, consist of, or consist essentially of a therapeutic agent and/or a modifying moiety. The modified neuroactive steroid can have modified characteristics as compared to native neuroactive steroids that do not include a modifying moiety and/or therapeutic agent. The modified neuroactive steroid may be, for example, modified pregnenolone, pregnenolone metabolites, allopregnanolone, and/or allopregnanolone metabolites. The modified neuroactive steroids can be used to treat, prevent and/or ameliorating a phenotypic state of interest in a subject. |
| FILED | Tuesday, June 21, 2022 |
| APPL NO | 17/807891 |
| CURRENT CPC | Steroids C07J 7/001 (20130101) Original (OR) Class C07J 7/007 (20130101) C07J 7/0045 (20130101) C07J 13/007 (20130101) C07J 31/006 (20130101) C07J 41/0005 (20130101) C07J 41/005 (20130101) C07J 43/003 (20130101) C07J 51/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20220341856 | YUEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Max YUEN (San Francisco, California); Yao-Te CHENG (Sunnyvale, California); Paul Christopher HANSEN (Palo Alto, California); Lambertus HESSELINK (Atherton, California) |
| ABSTRACT | In accordance with the invention, an X-ray amplitude analyzer grating adapted for use in an interferometric imaging system, the interferometric imaging system comprising an X-ray source and an X-ray detector with an X-ray fringe plane between the X-ray source and the X-ray detector, wherein an X-ray fringe pattern is formed at the X-ray fringe plane, wherein the X-ray amplitude analyzer grating is provided. The X-ray amplitude analyzer grating comprises a plurality of grating pixels across two dimensions of the X-ray amplitude analyzer grating, wherein each grating pixels of the plurality of grating pixels has a different pattern with respect to all adjacent grating pixels to the grating pixel so that all adjacent grating pixels do not have a same pattern as the grating pixel. |
| FILED | Friday, September 04, 2020 |
| APPL NO | 17/639558 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/041 (20180201) Original (OR) Class G01N 23/046 (20130101) G01N 23/083 (20130101) G01N 2223/04 (20130101) G01N 2223/30 (20130101) G01N 2223/401 (20130101) G01N 2223/419 (20130101) Image Data Processing or Generation, in General G06T 11/008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220341930 | JOHNSTON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents on Behalf of Arizona state University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen JOHNSTON (Tempe, Arizona); Lu Wang (Tempe, Arizona) |
| ABSTRACT | Assays, arrays, and methods for distinguishing a bacterial infection from a viral infection are disclosed. The antibiotic crisis is in part driven by over prescription of antibiotics. There is a tendency, particular in pediatrics, to give an antibiotic even for viral infections. Thus, embodiments herein are directed to the problem of distinguishing a bacterial infection from a viral infection to reduce unnecessary antibiotic usage. |
| FILED | Thursday, June 09, 2022 |
| APPL NO | 17/806242 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56911 (20130101) Original (OR) Class G01N 33/56983 (20130101) G01N 2469/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220344886 | Galvanauskas et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Almantas Galvanauskas (Ann Arbor, Michigan); Theodore Mathew Whittlesey (St. Clair, Michigan) |
| ABSTRACT | A laser system includes a signal source configured to generate input pulses, a diffraction grating module configured to stretch and split the input pulses into a plurality of spectral channels, a set of phase control devices, each phase control device being configured for spectral phase control of a respective spectral channel of the plurality of spectral channels, a power amplifier array of amplifier modules, each amplifier module of the power amplifier array being configured to amplify a respective spectral channel of the plurality of spectral channels, a spectral combiner configured to spectrally combine the plurality of spectral channels via diffraction grating-based pulse compression, and a feedback controller coupled to the spectral combiner to provide feedback to the set of phase control devices for pulse shaping. |
| FILED | Tuesday, October 06, 2020 |
| APPL NO | 17/765787 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 27/1086 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/0057 (20130101) Original (OR) Class H01S 3/1307 (20130101) H01S 3/06754 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20220338453 | Dunham et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AUBURN UNIVERSITY (Auburn, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rex A. Dunham (Auburn, Alabama); Michael Coogan (Auburn, Alabama); Michael Cone (Ann Arbor, Michigan); Veronica Alston (Auburn, Illinois) |
| ABSTRACT | Descried in certain example embodiments herein are engineered fish, particularly engineered catfish, that are engineered to contain modified myostatin, melanocortin-4 receptor, and/or one or more n-3 fatty acid biosynthesis pathway genes and/or gene products. |
| FILED | Monday, April 18, 2022 |
| APPL NO | 17/723159 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0276 (20130101) Original (OR) Class A01K 2217/054 (20130101) A01K 2227/40 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220338471 | Park et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Kansas State University Research Foundation (Manhattan, Kansas); The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia); Board of Regents of The University of Nebraska (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yoonseong Park (Manhattan, Kansas); Ronald Nachman (College Station, Texas); Troy Anderson (Lincoln, Nebraska) |
| ABSTRACT | Described herein are bee-safe acaricides that target the varroa mite-specific neuropeptidergic system regulated by proctolin, and methods of use. The acaricides comprise a peptide analog or peptidomimetic of varroa mite proctolin for selective targeting of this pest in a bee colony. The compounds are also effective against other pests, such as ticks. The peptide analog or peptidomimetic generally comprises one or two amino acid residue substitutions or insertions. Also described herein are methods of screening compounds for activity on a proctolin receptor. |
| FILED | Wednesday, September 23, 2020 |
| APPL NO | 17/762994 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 25/02 (20130101) A01N 25/12 (20130101) A01N 25/32 (20130101) Original (OR) Class Biocidal, Pest Repellant, Pest Attractant or Plant Growth Regulatory Activity of Chemical Compounds or Preparations A01P 7/00 (20210801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20220340177 | Khayatian et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents on Behalf of Arizona State University (Tempe, Arizona) |
| ASSIGNEE(S) | National Taiwan University (Taipei City, Taiwan) |
| INVENTOR(S) | Mohammad Khayatian (Tempe, Arizona); Mohammadreza Mehrabian (Tempe, Arizona); Harshith Allamsetti (Milpitas, California); Kai- Wei Liu (Taipei City, Taiwan); Po-Yu Huang (Taipei City, Taiwan); Chung-Wei Lin (Taipei City, Taiwan); Aviral Shrivastava (Phoenix, Arizona) |
| ABSTRACT | Various embodiments for systems and methods for cooperative driving of connected autonomous vehicles using responsibility-sensitive safety (RSS) rules are disclosed herein. The CAV system integrates proposed RSS rules with CAV's motion planning algorithm to enable cooperative driving of CAVs. The CAV system further integrates a deadlock detection and resolution system for resolving traffic deadlocks between CAVs. The CAV system reduces redundant calculation of dependency graphs. |
| FILED | Wednesday, March 16, 2022 |
| APPL NO | 17/696450 |
| CURRENT CPC | Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 30/18109 (20130101) B60W 60/00272 (20200201) Original (OR) Class B60W 60/00274 (20200201) B60W 2554/4041 (20200201) B60W 2554/4049 (20200201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220341826 | Adolphson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | INNOVAPREP LLC (Drexel, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alec D. Adolphson (Raymore, Missouri); Andrew E. Page (Smithton, Missouri); John D. Birkenholz (Kansas City, Missouri); David Goad (Stillwater, Oklahoma) |
| ABSTRACT | Devices, systems and methods are disclosed which relate to a prefiltration device that can be used with the concentrating pipette instruments and other devices which draw a sample in through one opening and dispense a concentrated or eluted sample out through the same opening. The device allows the sample to be passed through a prefilter when entering the opening and then bypassed the prefilter when being dispensed through the same opening. |
| FILED | Friday, April 22, 2022 |
| APPL NO | 17/726625 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502753 (20130101) B01L 2300/0681 (20130101) B01L 2300/0832 (20130101) B01L 2400/0683 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/34 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20220340308 | Moses et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA (WASHINGTON, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert W. Moses (Poquoson, Virginia); Foy M. Cheatwood (Norfolk, Virginia); Christopher O. Johnston (Yorktown, Virginia); Sergey Macheret (West Lafayette, Indiana); Bernard Parent (Tucson, American Samoa); Justin Little (Seattle, Washington) |
| ABSTRACT | A magnetohydrodynamic (MHD) flow control mechanism is described which substantially improves the existing processes in that smaller magnetic fields, requiring far less mass, are placed away from the forebody of the spacecraft to produce Lorentz forces that augment the lift and the drag forces for guidance, navigation, and control of the spacecraft. |
| FILED | Friday, April 22, 2022 |
| APPL NO | 17/727009 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/32 (20130101) Original (OR) Class Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 7/02 (20130101) H01F 7/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220344067 | Ales et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BWXT Nuclear Energy, Inc. (Lynchburg, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew W. Ales (Puyallup, Washington); Emily D. Fleming (Forest, Virginia); Ted L. Thome (Cuyahoga Falls, Ohio) |
| ABSTRACT | An aft plenum assembly for use with a nuclear thermal reactor including a pressure vessel and a nozzle assembly having a top plenum plate disposed within the pressure vessel, the top plenum plate defining a first plurality of fuel flow apertures, a bottom plenum plate disposed within the pressure vessel, the bottom plenum plate being parallel to the top plenum plate thereby defining a plenum space therebetween, the bottom plenum plate defining a second plurality of fuel flow apertures, and a plurality of tubular connections extending between the first plurality of fuel flow apertures of the top plenum plate and the second plurality of fuel flow apertures of the bottom plenum plate, wherein the aft plenum assembly is disposed between the pressure vessel and the nozzle assembly. |
| FILED | Wednesday, April 27, 2022 |
| APPL NO | 17/731003 |
| CURRENT CPC | Nuclear Reactors G21C 1/322 (20130101) G21C 1/324 (20130101) G21C 15/253 (20130101) Original (OR) Class Nuclear Power Plant G21D 5/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20220343273 | BRIGGMAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chandra A. BRIGGMAN (Springfield, Virginia); Jane Elizabeth QUENK (Washington, District of Columbia); Timothy M. MORAN (National Harbor, Maryland); Thomas J. FOTI (Annandale, Virginia); Robert E. DIXON, JR. (Washington, District of Columbia) |
| ABSTRACT | A method, electronic device, and computer-readable storage medium for delivering supplemental physical and/or electronic content in association with a physical delivery item. Various embodiments include operations for receiving tracking data regarding a delivery item, determining, based on the tracking data, whether supplemental content is associated with the delivery item, and automatically scheduling delivery of the supplemental content when supplemental content is associated with the delivery item. Others embodiments include operations for obtaining tracking data regarding a delivery item; identifying, based on the tracking data, supplemental content associated with the delivery item; generating an electronic command to schedule delivery of the supplemental content at a delivery point of a user, the scheduled delivery being associated with a corresponding delivery date; and generating an electronic command to present, within a user interface, at least one of the electronic items of supplemental content to the user on the corresponding delivery date. |
| FILED | Thursday, July 07, 2022 |
| APPL NO | 17/859166 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/10 (20130101) G06Q 10/083 (20130101) G06Q 10/0833 (20130101) Original (OR) Class G06Q 10/1093 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 51/42 (20220501) H04L 51/214 (20220501) H04L 51/234 (20220501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20220341342 | Nauss et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Nauss (Cincinnati, Ohio); Eric Alan Ford (Fort Thomas, Kentucky); Hans R. Wagner (Liberty Township, Ohio) |
| ABSTRACT | A variable vane apparatus includes: a case including two or more spaced-apart case pivots; a bellcrank pivotally connected to each case pivot, each of the bellcranks having an input arm and an output arm; a master rod including two or more segments pivotally connected to each other at rod pivots; and wherein the input arm of each of the bellcranks is pivotally connected to one of the rod pivots. |
| FILED | Wednesday, April 21, 2021 |
| APPL NO | 17/236105 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 9/041 (20130101) F01D 17/162 (20130101) Original (OR) Class Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 9/22 (20130101) Jet-propulsion Plants F02K 3/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220342568 | Roberts |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Andrew Roberts (Wellesley, Massachusetts) |
| ABSTRACT | Various embodiments provide for one or more processor instructions and memory instructions that enable a memory sub-system to copy, move, or swap data across (e.g., between) different memory tiers of the memory sub-system, where each of the memory tiers is associated with different memory locations (e.g., different physical memory locations) on one or more memory devices of the memory sub-system. |
| FILED | Friday, April 23, 2021 |
| APPL NO | 17/238791 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/0605 (20130101) G06F 3/0631 (20130101) Original (OR) Class G06F 3/0647 (20130101) G06F 3/0653 (20130101) G06F 3/0659 (20130101) G06F 3/0679 (20130101) G06F 12/0238 (20130101) G06F 12/0292 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, October 27, 2022.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20221027.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page