FedInvent™ Patent Applications
Application Details for Thursday, November 03, 2022
This page was updated on Saturday, November 05, 2022 at 05:09 PM GMT
Department of Health and Human Services (HHS)
| US 20220346659 | Ma et al. |
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| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dan Ma (Solon, Ohio); Chaitra Badve (Moreland Hills, Ohio); Charit Tippareddy (Cleveland, Ohio); Walter Zhao (Cleveland Heights, Ohio) |
| ABSTRACT | Radiomic analysis of multiparametric magnetic resonance imaging (“MRI”) and magnetic resonance fingerprinting (“MRF”) data enhances delineation and mapping of tumor regions. Radiomic features are extracted from MRI and MRF tumor images. Distinct tumor regions, including but not limited to necrotic core, enhancing tumor, and peritumoral white matter, are segmented and mapped. Whole tumor as well as tumor region characteristics are evaluated. Tumors can also be differentiated and classified by pathology, grading, staging, and so on. Tumor infiltration into peritumoral white matter regions can also be mapped for recurrence prediction |
| FILED | Monday, May 02, 2022 |
| APPL NO | 17/661656 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) Original (OR) Class A61B 5/7282 (20130101) A61B 2576/00 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/5601 (20130101) G01R 33/5608 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 15/00 (20180101) G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220346760 | GRACIAS et al. |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
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| INVENTOR(S) | David GRACIAS (Baltimore, Maryland); Kate MALACHOWSKI (Silver Spring, Maryland) |
| ABSTRACT | Microgrippers adapted to capture, manipulate, and contain single cells in both in vitro and in vivo cell applications are disclosed. The energy required to actuate these microgrippers is derived from the release of residual stress and does not require any wires, tethers, or batteries. Because the microgrippers are made from biocompatible and biosorbable materials, they do not accumulate in tissue. Accordingly, they can be used for in vivo applications, such as for gripping single cells in tissue biopsies. |
| FILED | Monday, May 16, 2022 |
| APPL NO | 17/745044 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 10/04 (20130101) A61B 10/0233 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220346956 | Criscione et al. |
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| APPLICANT(S) | THE TEXAS A and M UNIVERSITY SYSTEM (College Station, Texas); CORINNOVA INCORPORATED (Houston, Texas) |
| ASSIGNEE(S) | THE TEXAS A and M UNIVERSITY SYSTEM (College Station, Texas); CORINNOVA INCORPORATED (Houston, Texas) |
| INVENTOR(S) | John C. Criscione (College Station, Texas); Lewis D. Harrison (Flower Mound, Texas); Michael R. Moreno (College Station, Texas); Christina M. Bolch (Houston, Texas); Dennis I. Robbins (Richardson, Texas); Saurabh Biswas (College Station, Texas); Boris Leschinsky (Mahwah, New Jersey) |
| ABSTRACT | The present invention provides methods, systems, kits, and cardiac compression devices that have both passive chambers and active chambers to improve heart function. |
| FILED | Monday, July 11, 2022 |
| APPL NO | 17/861581 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/2481 (20130101) Original (OR) Class Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 60/148 (20210101) A61M 60/191 (20210101) A61M 60/289 (20210101) A61M 60/468 (20210101) A61M 60/839 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220347113 | Du et al. |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
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| INVENTOR(S) | Xiaoping Du (Willowbrook, Illinois); Ni Cheng (Urbana, Illinois) |
| ABSTRACT | The present disclosure provides peptides that inhibit a binding interaction between a β integrin and a G protein subunit, as well as compositions, e.g., pharmaceutical compositions, particularly nanoparticle compositions, comprising the same and to methods of using the peptides to treat atherosclerosis, thrombosis, stroke, heart attack, inflammation, acute respiratory distress syndrome (ARDS), autoimmune diseases, AV Fistula for hemodialysis or organ transplantation. |
| FILED | Monday, November 09, 2020 |
| APPL NO | 17/773882 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5123 (20130101) Original (OR) Class A61K 9/5146 (20130101) A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/02 (20180101) A61P 29/00 (20180101) Peptides C07K 14/70557 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220347115 | Wang et al. |
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| APPLICANT(S) | DUKE UNIVERSITY (Durham, North Carolina); OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio) |
| ASSIGNEE(S) | DUKE UNIVERSITY (Durham, North Carolina); OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio) |
| INVENTOR(S) | Qianben Wang (Durham, North Carolina); Zhifen Cui (Durham, North Carolina); Yizhou Dong (Columbus, Ohio) |
| ABSTRACT | The present application relates to nanoparticles for the targeted delivery of CRISPR/Cas13 systems, and their therapeutic use to treat diseases and disorders such as prostate cancer and COVID-19. |
| FILED | Monday, July 13, 2020 |
| APPL NO | 17/626482 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5153 (20130101) Original (OR) Class A61K 31/7105 (20130101) A61K 38/465 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 13/08 (20180101) A61P 31/14 (20180101) A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220347141 | BERGWITZ et al. |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut); THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Indiana); BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
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| INVENTOR(S) | Clemens BERGWITZ (New Haven, Connecticut); Lynda BONEWALD (Indianapolis, Indiana); Marco BROTTO (Austin, Texas) |
| ABSTRACT | Provided herein are methods and compositions for treating nephropathic conditions such as chronic kidney disease, as well as phosphate concentration disorders and myopathy related to phosphate concentration disorders. The methods and compositions include administering a therapeutically effective amount of L-BAIBA ((S)-β-aminoisobutyric acid) to a subject in need thereof. |
| FILED | Thursday, September 17, 2020 |
| APPL NO | 17/761020 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/197 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/12 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220347144 | Fox et al. |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| INVENTOR(S) | Todd E. Fox (Charlottesville, None); Mark Kester (Afton, None) |
| ABSTRACT | Provided are methods for preventing and/or reducing weight gain in subjects. In some embodiments, the methods include administering an effective amount of a composition that includes a long chain fatty acid of at least 22 carbons and/or a derivative thereof to prevent and/or reduce weight gain in the subject. In some embodiments, the long chain fatty acid is a monounsaturated omega 9 fatty acid, which in some embodiments is nervonic acid or a derivative thereof. Also provided are methods for preventing and/or reducing the development of obesity in subjects, for inhibiting reduction of very-long chain sphingolipids in subjects, for increasing content of one or more ceramides while simultaneously decreasing content of one or more C20-C26 ceramides in subjects, and for reducing blood glucose levels resulting from consumption of high fat diets in subjects. |
| FILED | Monday, September 28, 2020 |
| APPL NO | 17/763798 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/201 (20130101) Original (OR) Class A61K 31/231 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/04 (20180101) A61P 3/06 (20180101) A61P 3/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220347159 | Ehrlich |
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| APPLICANT(S) | YALE UNIVERSITY (NEW HAVEN, Connecticut) |
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| INVENTOR(S) | Barbara Ehrlich (New Haven, Connecticut) |
| ABSTRACT | The present invention is directed to a novel treatment for Wolfram Syndrome or heterozygous wolframin, to methods of treatment in order to delay, inhibit, ameliorate and/or reduce the likelihood of symptomology of a patient with Wolfram Syndrome or heterozygous wolframin. |
| FILED | Tuesday, May 26, 2020 |
| APPL NO | 17/610041 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4162 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) A61P 7/12 (20180101) A61P 27/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220347161 | Cassis et al. |
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| APPLICANT(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lisa Cassis (Nicholasville, Kentucky); Sean Thatcher (Lexington, Kentucky); Yasir Alsiraj (Lexington, Kentucky); Mark Ensor (Lexington, Kentucky); Eric Blalock (Lexington, Kentucky) |
| ABSTRACT | Methods of treating or reducing risk of aneurysm, reducing cardiovascular risk, reducing serum cholesterol, reducing serum triglycerides, and/or reducing atherosclerotic plague in a subject involve administering to the subject an effective amount of a 5HT3R antagonist. |
| FILED | Monday, May 02, 2022 |
| APPL NO | 17/734571 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/46 (20130101) A61K 31/439 (20130101) Original (OR) Class A61K 31/4178 (20130101) A61K 31/4184 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/06 (20180101) A61P 9/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220347163 | GUDAS et al. |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York); ALBERT EINSTEIN COLLEGE OF MEDICINE (Bronx, New York) |
| ASSIGNEE(S) | CORNELL UNIVERSITY (Ithaca, New York); ALBERT EINSTEIN COLLEGE OF MEDICINE (Bronx, New York) |
| INVENTOR(S) | Lorraine J. GUDAS (New York, New York); Xiao-Han Tang (Staten Island, New York); Roberto Levi (New York, New York); Jessica Gambardella (Bronx, New York); Gaetano Santulli (New York, New York) |
| ABSTRACT | The invention provides compositions and methods for providing a cardioprotective effect in a subject. Specifically, the invention relates to compositions and methods for treating cardiovascular ailments, such as compositions and methods for attenuating or ameliorating the development of cardiac contractile dysfunction, myocardial fibrosis or maladaptive remodeling in a subject having or having had a myocardial infarction (MI) or at risk of having a myocardial infarction by administering a retinoic acid receptor-beta (RARβ) agonist. |
| FILED | Thursday, June 30, 2022 |
| APPL NO | 17/855772 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/192 (20130101) A61K 31/426 (20130101) A61K 31/4436 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/06 (20180101) A61P 9/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220347167 | Liu |
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| APPLICANT(S) | The Schepens Eye Research Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yang Liu (Winchester, Massachusetts) |
| ABSTRACT | The invention provides compositions and methods for reducing oxygen concentration in the environment of or promoting the expression or function of at least one hypoxia inducible factor (HIF) in one or more dysfunctional meibomian glands (MGs), utilizing a low oxygen mimetic agent capable of promoting the expression or function of at least one HIF and mimicking a low oxygen environment, or a combination thereof, to improve MG functions. |
| FILED | Friday, October 02, 2020 |
| APPL NO | 17/766029 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0051 (20130101) A61K 31/16 (20130101) A61K 31/22 (20130101) A61K 31/47 (20130101) Original (OR) Class A61K 33/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220347182 | Bhutani et al. |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
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| INVENTOR(S) | Nidhi Bhutani (Stanford, California); Fiorella Carla Grande (Stanford, California) |
| ABSTRACT | Provided herein are methods and compositions for reducing inflammation and/or treating osteoarthritis in a patient in need thereof. The methods include administering to the patient an inhibitor of an inflammation amplifying (Inf-A) population of chondrocytes and an activator of an inflammation dampening (Inf-D) population of chondrocytes. The methods include exposing the osteoarthritic chondrocytes to a composition including an effective amount of an ALK5 inhibitor, a JNK kinase inhibitor, a TNFR II receptor inhibitor, and/or IL1R1 receptor inhibitor and an effective amount of a CD24 activator. |
| FILED | Friday, October 02, 2020 |
| APPL NO | 17/765086 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/522 (20130101) Original (OR) Class A61K 31/4439 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220347212 | McCully et al. |
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| APPLICANT(S) | Children`s Medical Center Corporation (Boston, Massachusetts) |
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| INVENTOR(S) | James D. McCully (Marblehead, Massachusetts); Pedro J. del Nido (Lexington, Massachusetts) |
| ABSTRACT | The disclosure relates to compositions comprising isolated mitochondria or combined mitochondrial agents, and methods of treating or preventing disorders or damage associated with ischemia-reperfusion injury (IRI) using such compositions. |
| FILED | Wednesday, October 30, 2019 |
| APPL NO | 17/607975 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/504 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 35/12 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220347222 | PAREKH et al. |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); Children's Hospital Los Angeles (Los Angeles, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California); Children's Hospital Los Angeles (Los Angeles, California) |
| INVENTOR(S) | Chintan PAREKH (Los Angeles, California); Gay CROOKS (Los Angeles, California); Christopher SEETS (Los Angeles, California); Amelie Montel-Hagen (Los Angeles, California) |
| ABSTRACT | Methods of treating a subject using a T cell therapy are disclosed herein. The methods include increasing BCL11B expression in hematopoietic stem and progenitor cells (HSPCs), pluripotent stem cells, or mature T cells to form modified cells and administering a therapeutically effective amount of the modified cells to the subject for the T cell therapy. BCL11B expression in the HSPCs, pluripotent stem cells, or mature T cells increases production and/or proliferation of T cells from the HSPCs and/or the pluripotent stem cells, and/or increases proliferation of the T cells. |
| FILED | Wednesday, June 24, 2020 |
| APPL NO | 17/620603 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 35/28 (20130101) Original (OR) Class A61K 35/545 (20130101) A61K 38/177 (20130101) A61K 38/1774 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220347267 | Bertenshaw et al. |
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| APPLICANT(S) | Biomarker Strategies, LLC (Rockville, Maryland) |
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| INVENTOR(S) | Greg P. Bertenshaw (Rockville, Maryland); Marika Magdelena Smith (Rockville, Maryland); Meena Chandok (Rockville, Maryland); Senthamil Selvan (Rockville, Maryland); William Murphy (Rockville, Maryland); Palak Parekh (Rockville, Maryland) |
| ABSTRACT | The present invention provides methods to improve a cancer patient's response to immune checkpoint inhibitor (ICI) therapy, and functional test to predict likelihood of response. Specifically, the invention provides methods to improve patient's response to immune checkpoint inhibitors using modulators and to predict response to the combination of immune checkpoint inhibitors and modulators. |
| FILED | Thursday, September 17, 2020 |
| APPL NO | 17/761077 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/19 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/02 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57484 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220347282 | McNeel et al. |
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| APPLICANT(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin) |
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| INVENTOR(S) | Douglas McNeel (Madison, Wisconsin); Christopher D. Zahm (Madison, Wisconsin); Jena Moseman (Madison, Wisconsin) |
| ABSTRACT | The present invention provides combination therapies and methods of treating cancer, including, cancers that are resistant to PD-1 therapy. The combination therapies described herein comprise a DNA vaccine to a tumor antigen, anti-PD-1 therapy, and an anti-LAG-3 therapy, which provides an increased T cell response against the cancer. |
| FILED | Thursday, April 28, 2022 |
| APPL NO | 17/732237 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/001102 (20180801) A61K 39/001106 (20180801) A61K 39/001184 (20180801) Original (OR) Class A61K 39/001193 (20180801) A61K 39/001194 (20180801) A61K 39/3955 (20130101) A61K 2039/53 (20130101) A61K 2039/505 (20130101) A61K 2039/545 (20130101) A61K 2039/572 (20130101) A61K 2039/868 (20180801) A61K 2039/884 (20180801) A61K 2039/892 (20180801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 37/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220347295 | Harn et al. |
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| APPLICANT(S) | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (Athens, Georgia) |
| ASSIGNEE(S) | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (Athens, Georgia) |
| INVENTOR(S) | Donald A. Harn (Athens, Georgia); Rafaella Queiroz (Minas Gerais, Brazil); Lisa Shollenberger (Norfolk, Virginia); Emily-Joy Farrah Samli (Athens, Georgia) |
| ABSTRACT | A vaccine delivery method is presented that includes a composition including as one component a slurry matrix that is a liquid at room temperature and a gel at physiological pH, physiological salt concentrations and/or physiological temperatures and as a second component one or more antigens. Also included are methods of inducing an immune response in a subject and vaccinating a subject by administering such compositions. |
| FILED | Monday, June 13, 2022 |
| APPL NO | 17/838890 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/0019 (20130101) A61K 39/00 (20130101) A61K 39/0003 (20130101) A61K 39/04 (20130101) A61K 39/05 (20130101) A61K 39/08 (20130101) A61K 39/012 (20130101) A61K 39/12 (20130101) A61K 39/15 (20130101) A61K 39/17 (20130101) A61K 39/29 (20130101) A61K 39/39 (20130101) Original (OR) Class A61K 39/085 (20130101) A61K 39/092 (20130101) A61K 39/099 (20130101) A61K 39/102 (20130101) A61K 39/104 (20130101) A61K 39/145 (20130101) A61K 39/155 (20130101) A61K 39/0208 (20130101) A61K 39/215 (20130101) A61K 39/255 (20130101) A61K 39/0258 (20130101) A61K 39/265 (20130101) A61K 39/0275 (20130101) A61K 39/292 (20130101) A61K 39/1045 (20130101) A61K 47/42 (20130101) A61K 2039/53 (20130101) A61K 2039/54 (20130101) A61K 2039/545 (20130101) A61K 2039/552 (20130101) A61K 2039/575 (20130101) A61K 2039/5252 (20130101) A61K 2039/55505 (20130101) A61K 2039/55516 (20130101) A61K 2039/55555 (20130101) A61K 2039/55561 (20130101) A61K 2039/55566 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2710/16334 (20130101) C12N 2710/16734 (20130101) C12N 2710/24034 (20130101) C12N 2720/10034 (20130101) C12N 2720/12334 (20130101) C12N 2730/10134 (20130101) C12N 2750/10034 (20130101) C12N 2750/14334 (20130101) C12N 2760/16134 (20130101) C12N 2760/16171 (20130101) C12N 2760/18034 (20130101) C12N 2760/18134 (20130101) C12N 2770/10034 (20130101) C12N 2770/20034 (20130101) C12N 2770/24334 (20130101) C12N 2770/32334 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220347297 | Byrne et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| INVENTOR(S) | Barry John Byrne (Gainesville, Florida); Darin Falk (Gainesville, Florida); Manuela Corti (Alachua, Florida) |
| ABSTRACT | Provided herein are compositions, kits and methods related to permitting a human or non-human primate subject to receive multiple doses of recombinant adeno-associate virus (rAAV) vectors. In some aspects, provided herein are methods comprising administering an anti-CD20 antibody, optionally in combination with an mTOR inhibitor, to the subject to permit multiple doses of an rAAV vector to be administered. |
| FILED | Friday, March 04, 2022 |
| APPL NO | 17/686624 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/436 (20130101) A61K 38/47 (20130101) A61K 39/3955 (20130101) Original (OR) Class A61K 39/39558 (20130101) A61K 48/0083 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/06 (20130101) C07K 16/2887 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220347315 | Li et al. |
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| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina); TEXAS TECH UNIVERSITY SYSTEM (Lubbock, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chengwen Li (Chapel Hill, North Carolina); R. Bryan Sutton (Lubbock, Texas) |
| ABSTRACT | The invention relates to methods and compositions for increasing introduction (e.g., transduction) efficiency. In particular, the invention relates to methods of increasing introduction (e.g., transduction) efficiency by contacting a host cell with a heterologous agent in the presence of a cell membrane fusion protein or a functional fragment or derivative thereof. The invention further relates to compositions that include a heterologous agent and a cell membrane fusion protein or a functional fragment or derivative thereof. |
| FILED | Friday, November 20, 2020 |
| APPL NO | 17/756273 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/0008 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20220347316 — CD25 PRE-SELECTIVE COMBINATION ANTI-HIV VECTORS, TARGETING VECTORS, AND METHODS OF USE
| US 20220347316 | Anderson |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph Anderson (Davis, California) |
| ABSTRACT | Recombinant vectors containing at least: a backbone comprising essential sequences for integration into a target cell genome; a nucleic acid encoding a CCR5 RNAi operatively linked to a a first expression control element that regulates expression of the nucleic acid encoding the RNAi of the CCR5; a nucleic acid encoding at least the extracellular domain of CD25 operatively linked to a second expression control element that regulates expression of the nucleic acid encoding at least the extracellular domain of CD25 are provided by this disclosure. In an alternative aspect, the vector also contains polynucleotides encoding TRIM5alpha and HIV TAR decoy sequences along with gene expression regulation elements such as promoters operatively linked to the polynucleotides. The vectors are combined with packaging plasmid and envelope plasmids and optionally conjugated to cell-specific targeting antibodies. Diagnostic and therapeutic methods for using the compositions are further provided herein. |
| FILED | Thursday, December 02, 2021 |
| APPL NO | 17/541018 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) A61K 47/6901 (20170801) A61K 48/005 (20130101) A61K 48/0058 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0647 (20130101) C12N 7/00 (20130101) C12N 15/86 (20130101) C12N 15/1138 (20130101) C12N 2310/14 (20130101) C12N 2510/02 (20130101) C12N 2740/15042 (20130101) C12N 2740/15043 (20130101) C12N 2740/15045 (20130101) C12N 2740/15052 (20130101) C12N 2810/859 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220347318 | Hartnett et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Utah Research Foundation (Salt Lake City, Utah); University of Florida (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mary Elizabeth Hartnett (Salt Lake City, Utah); Haibo Wang (Salt Lake City, Utah); William Hauswirth (Knoxville, Tennessee); Vince Chiodo (Gainesville, Florida) |
| ABSTRACT | Disclosed are nucleic acid constructs comprising a nucleic acid sequence encoding a vitelliform macular dystrophy-2 (VMD2) promoter operably linked to a nucleic acid sequence encoding Rap1a. Disclosed are vectors comprising the nucleic acid constructs disclosed herein. Disclosed are compositions comprising the disclosed nucleic acid constructs or vectors. Also disclosed are methods of treating a subject having age-related macular degeneration comprising administering one or more of the disclosed nucleic acid constructs, vectors, or compositions to a subject in need thereof. |
| FILED | Friday, September 25, 2020 |
| APPL NO | 17/763767 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0048 (20130101) A61K 38/46 (20130101) A61K 38/177 (20130101) A61K 45/06 (20130101) A61K 48/0066 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) Peptides C07K 14/705 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/14 (20130101) C12N 15/86 (20130101) C12N 2780/00043 (20130101) C12N 2780/00071 (20130101) Enzymes C12Y 306/05002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220347319 | BANKIEWICZ et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Krystof BANKIEWICZ (Oakland, California); Adrian P. KELLS (San Francisco, California) |
| ABSTRACT | The invention provides methods for treating neurological disorders, which involve administering therapeutic agents to the thalamus by convection enhanced delivery. |
| FILED | Thursday, March 17, 2022 |
| APPL NO | 17/697841 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/0075 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220347321 | Anderson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David J. Anderson (Altadena, California); Moriel Zelikowsky (Pasadena, California) |
| ABSTRACT | Methods of expressing a neuropeptide in a neuron of a subject are described. Methods of altering a behavior in a subject in need thereof are described. Kits are described. Vectors are described. |
| FILED | Tuesday, June 28, 2022 |
| APPL NO | 17/809376 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/5513 (20130101) A61K 48/0083 (20130101) Original (OR) Class Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 2005/0663 (20130101) Peptides C07K 14/47 (20130101) C07K 14/70571 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220347322 | Wang |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rong Wang (San Francisco, California) |
| ABSTRACT | The disclosure provides a mouse model of arteriovenous malformation, such as found in Hereditary Hemorrhagic Telangiectasia, that accurately and persistently models the disease progression in various organisms, including humans. The disclosure further provides a mouse comprising a mutant Ephrin pathway gene, such as Alk1, in brain endothelial cells only, and methods of screening for therapeutically useful modulators of Ephrin pathway gene expression or gene product activity useful in treating or ameliorating a symptom of arteriovenous malformation, such as Hereditary Hemorrhagic Telangiectasia or hemorrhagic stroke. |
| FILED | Wednesday, September 30, 2020 |
| APPL NO | 17/764892 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/0008 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5041 (20130101) G01N 2800/7033 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220347323 | Shackelford et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Shackelford (Rancho Palos Verdes, California); Saman Sadeghi (Sherman Oaks, California); Milica Momcilovic (Los Angeles, California) |
| ABSTRACT | A method for detecting or ruling out non-small cell lung cancer (NS-CLC) in a patient comprises: (a) administering to a patient a detectable amount of a compound of formula (I): Formula (I) wherein the compound is targeted to any NSCLC tumor in the patient; and (b) acquiring an image to detect the presence or absence of any NSCLC tumor in the patient, wherein at least one of the atoms in formula (I) is replaced with 11C, 13N, 15O, 18F, 34mCI, 38K, 45Ti, 51Mn, 52Mn, 52Fe, 55Co, 60CU, 61Cu, 62Cu, 64Cu, 66Ga, 68Ga, 71As, 72As, 74As, 75Br, 75Br, 76Br, 82Rb, 86Y, 89Zr, 90Nb, 94mTc, 110mIn, 118Sb, 120I, 121I, 122I, and 124I. |
| FILED | Friday, September 18, 2020 |
| APPL NO | 17/760846 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/032 (20130101) A61B 6/037 (20130101) A61B 6/50 (20130101) A61B 6/5235 (20130101) A61B 6/5247 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/155 (20130101) A61K 31/352 (20130101) A61K 31/454 (20130101) A61K 51/04 (20130101) Original (OR) Class A61K 51/0491 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220347362 | WU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, Maryland); BREETHE, INC. (Halethorpe, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhongjun WU (Marriottsville, Maryland); Bartley P. GRIFFITH (Gibson Island, Maryland); Jiafeng ZHANG (Silver Spring, Maryland); Steven J. ORWIG (Bowie, Maryland) |
| ABSTRACT | The device of the present invention includes a dual chamber gas exchanger that is configured for increased flexibility and scalability for many clinical applications. The dual chamber oxygenator can be configured and used in various applications, such as in a heart-lung machine for cardiopulmonary support during cardiothoracic surgery, in an extracorporeal membrane oxygenation (ECMO) circuitry, as a respiratory assist device for patients with lung failure, and the like. The dual chamber gas exchanger features two sweep gas flow paths and two gas exchange membrane bundles enclosed in a housing structure with various blood flow distribution and gas distribution mechanisms. The gas exchanger includes an outer housing, an intermediate housing, two gas exchange fiber bundles, a blood inlet, a blood outlet, two gas inlets, two gas outlets, two gas distribution chambers and an optional heat exchanger. |
| FILED | Thursday, July 07, 2022 |
| APPL NO | 17/859144 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/1629 (20140204) A61M 1/1698 (20130101) Original (OR) Class A61M 1/3607 (20140204) A61M 60/113 (20210101) A61M 2202/0225 (20130101) A61M 2206/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220347492 | Gach et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | H. Michael Gach (St. Louis, Missouri); Austen Curcuru (St. Louis, Missouri); Taeho Kim (St. Louis, Missouri); Umberto Villa (St. Louis, Missouri) |
| ABSTRACT | Devices, systems, and methods for enhancing MRI image quality and tracking accuracy in MR-guided treatment systems are described. |
| FILED | Tuesday, May 03, 2022 |
| APPL NO | 17/736088 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/1049 (20130101) Original (OR) Class A61N 2005/1055 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/565 (20130101) G01R 33/5608 (20130101) Image Data Processing or Generation, in General G06T 11/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220347677 | Delmenico et al. |
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| FUNDED BY |
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| APPLICANT(S) | Haemonetics Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | Haemonetics Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Peter Delmenico (Melbourne, Australia); Carlos G. Lopez-Espina (Evanston, Illinois); Gabriel Raviv (Glenview, Illinois) |
| ABSTRACT | A sample testing cartridge is usable to perform a variety of tests on a visco-elastic sample, such hemostasis testing on a whole blood or blood component sample. The cartridge includes a sample processing portion that is in fluid communication with a sample retention structure. A suspension, such as a beam, arm, cantilever or similar structure supports or suspends the sample retention portion relative to the sample processing portion in a unitary structure. In this manner, the sample retention portion may be placed into dynamic excitation responsive to excitation of the cartridge and correspondingly dynamic, resonant excitation of the sample contained within the sample retention portion, while the sample processing portion remains fixed. Observation of the excited sample yields data indicative of hemostasis. The data may correspond to hemostasis parameters such as time to initial clot formation, rate of clot formation, maximum clot strength and degree of clot lysis. |
| FILED | Thursday, June 30, 2022 |
| APPL NO | 17/855634 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502 (20130101) B01L 3/50273 (20130101) Original (OR) Class B01L 3/502753 (20130101) B01L 2300/165 (20130101) B01L 2300/0663 (20130101) B01L 2300/0816 (20130101) B01L 2300/0877 (20130101) B01L 2400/0433 (20130101) B01L 2400/0481 (20130101) B01L 2400/0487 (20130101) B01L 2400/0638 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 11/16 (20130101) G01N 29/032 (20130101) G01N 29/036 (20130101) G01N 29/2418 (20130101) G01N 33/4905 (20130101) G01N 2291/0251 (20130101) G01N 2291/0427 (20130101) G01N 2291/02466 (20130101) G01N 2291/02818 (20130101) G01N 2291/02827 (20130101) G01N 2800/224 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220347686 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Notre Dame du Lac (South Bend, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ceming Wang (South Bend, Indiana); Hsueh-Chia Chang (South Bend, Indiana) |
| ABSTRACT | Described herein is a size-based asymmetric nanopore membrane (ANM) filtration technology for high-efficiency exosome isolation, concentration, and fractionation. The ANM design prevents exosome deformation, lysing, and fusion due to the strong external force and thus significant increases the yield (up to 92%) while preserving other advantages of size-based ultrafiltration. It also offers a unique feature of being able to flush the contaminating proteins from the exosomes. It offers higher throughput, yield, sample purity, concentration factor, and more precise size fractionation than current approaches. |
| FILED | Tuesday, September 15, 2020 |
| APPL NO | 17/760531 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502753 (20130101) Original (OR) Class B01L 2300/0896 (20130101) B01L 2400/086 (20130101) B01L 2400/0409 (20130101) B01L 2400/0418 (20130101) B01L 2400/0487 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220347688 | Burns et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark A. Burns (Ann Arbor, Michigan); Alyse D. Krausz (Ann Arbor, Michigan); Sarah Elizabeth Mena (Ann Arbor, Michigan); Martin Patrick De Beer (Ann Arbor, Michigan); Kevin R. Ward (Superior Township, Michigan); Frederick Korley (Ann Arbor, Michigan) |
| ABSTRACT | A microfluidic device system includes a channel having an entrance and an exit, a height at the entrance being greater than a height at the exit. The height of the channel may decrease continuously from the height at the entrance to the height at the exit. Cells or particles or beads traveling through the channel become trapped based on their size and/or deformability. A visual sensor captures images of the trapped cells or particles or beads, and image software analyzes the captured images to provide size and/or deformability and/or fluorescence information. A method of fabricating such a microfluidic device includes introducing a glass wafer to an etching solution at a specific rate such that a first end of the glass wafer is etched longer than other portions of the glass wafer. |
| FILED | Thursday, July 07, 2022 |
| APPL NO | 17/859400 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502707 (20130101) B01L 3/502715 (20130101) B01L 3/502761 (20130101) Original (OR) Class B01L 2200/12 (20130101) B01L 2200/0668 (20130101) B01L 2300/0627 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/28 (20130101) G01N 15/1475 (20130101) G01N 21/6428 (20130101) G01N 33/6803 (20130101) G01N 33/54366 (20130101) G01N 2015/1493 (20130101) G01N 2021/6439 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348546 | TAVIS et al. |
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| FUNDED BY |
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| APPLICANT(S) | Saint Louis University (St. Louis, Missouri); Research Foundation of the City University of New York (New York, New York) |
| ASSIGNEE(S) | Saint Louis University (St. Louis, Missouri); Research Foundation of the City University of New York (New York, New York) |
| INVENTOR(S) | John Edwin TAVIS (Kirkwood, Missouri); Lynda Anne MORRISON (Webster Groves, Missouri); Maureen Jeanette DONLIN (Kirkwood, Missouri); Ryan P. MURELLI (Belleville, New Jersey) |
| ABSTRACT | The present disclosure provides inhibitors of microorganisms including viruses and fungi of the formula (I) or (II) wherein the variables are defined herein. Also provided are methods of treatment using these agents in the treatment of infections of microorganisms such as viruses and fungi. |
| FILED | Sunday, May 03, 2020 |
| APPL NO | 17/608256 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/12 (20180101) Acyclic or Carbocyclic Compounds C07C 233/58 (20130101) C07C 233/60 (20130101) C07C 233/63 (20130101) C07C 271/22 (20130101) C07C 311/18 (20130101) C07C 317/24 (20130101) C07C 2601/18 (20170501) Heterocyclic Compounds C07D 209/20 (20130101) C07D 211/26 (20130101) C07D 213/75 (20130101) C07D 229/02 (20130101) Original (OR) Class C07D 239/42 (20130101) C07D 271/12 (20130101) C07D 277/22 (20130101) C07D 295/185 (20130101) C07D 307/68 (20130101) C07D 317/28 (20130101) C07D 319/20 (20130101) C07D 333/20 (20130101) C07D 333/34 (20130101) C07D 413/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348558 | Golden et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jennifer Elizabeth Golden (Waunakee, Wisconsin); Xufeng Cao (West Lafayette, Wisconsin); Donghoon Chung (Prospect, Kentucky); Colleen Beth Jonsson (Knoxville, Tennessee); Xiaoyu Li (Madison, Wisconsin); Michael Ryan (Madison, Wisconsin); Jongwoo Son (Saha-gu, Busan, South Korea) |
| ABSTRACT | Compounds of Formula I and Formula II: pharmaceutical compositions containing them, and use of the compounds as active ingredients to treat infection with alphavirus. |
| FILED | Friday, September 04, 2020 |
| APPL NO | 17/639615 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Heterocyclic Compounds C07D 239/90 (20130101) C07D 401/14 (20130101) C07D 403/04 (20130101) Original (OR) Class C07D 403/14 (20130101) C07D 405/14 (20130101) C07D 413/14 (20130101) C07D 487/08 (20130101) C07D 491/107 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348581 | Blass et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Temple University-Of the Commonwealth System of Higher Education (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin E. Blass (Eagleville, Pennsylvania); Daniel J. Canney (Ambler, Pennsylvania); Kevin M. Blattner (Folsom, Pennsylvania) |
| ABSTRACT | Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity. |
| FILED | Friday, December 03, 2021 |
| APPL NO | 17/541682 |
| CURRENT CPC | Heterocyclic Compounds C07D 487/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348588 | SPEERSCHNEIDER et al. |
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| FUNDED BY |
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| APPLICANT(S) | Trevena, Inc. (Chesterbrook, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aimee CROMBIE SPEERSCHNEIDER (Chesterbrook, Pennsylvania); Dennis SHINJI YAMASHITA (Chesterbrook, Pennsylvania); Philip Michael PITIS (Chesterbrook, Pennsylvania); Michael John HAWKINS (Chesterbrook, Pennsylvania); Guodong Liu (Chesterbrook, Pennsylvania); Tamara Ann MISKOWSKI DAUBERT (Chesterbrook, Pennsylvania); Catherine C.K. YUAN (Chesterbrook, Pennsylvania); Robert BORBO KARGBO (Chesterbrook, Pennsylvania); Robert Jason HERR (Chesterbrook, Pennsylvania); Donna ROMERO (Chesterbrook, Pennsylvania) |
| ABSTRACT | The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof. |
| FILED | Monday, November 22, 2021 |
| APPL NO | 17/532413 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 23/00 (20180101) A61P 25/22 (20180101) A61P 25/24 (20180101) Heterocyclic Compounds C07D 223/04 (20130101) C07D 403/12 (20130101) C07D 403/14 (20130101) C07D 405/14 (20130101) C07D 417/14 (20130101) C07D 487/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348609 | Roy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington); CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anindya Roy (Seattle, Washington); Lei Shi (Seattle, Washington); Xianchi Dong (Boston, Massachusetts); Jing Li (Boston, Massachusetts); Timothy Springer (Boston, Massachusetts); David Baker (Seattle, Washington) |
| ABSTRACT | Alpha(v) beta (6) integrin (avb6) binding polypeptides are disclosed herein, and their use in treating and detecting tumors, and their use in treating pulmonary fibrosis. |
| FILED | Friday, October 23, 2020 |
| APPL NO | 17/763772 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 7/00 (20130101) Original (OR) Class C07K 14/495 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348617 | LUCA et al. |
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| FUNDED BY |
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| APPLICANT(S) | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vincent LUCA (Tampa, Florida); David Gonzalez Perez (Tampa, Florida) |
| ABSTRACT | Disclosed are compositions and methods for engineered DLL4 proteins. In one aspect, disclosed herein are engineered DLL4 proteins comprising a conservative amino acid substitution at a residue corresponding to residues 28, 107, 143, 194, and 206 as set forth in SEQ ID NO: 1 and further comprising at least one conservative amino acid substitution at residues 256, 257, 271, 280, 301, and 305 as set forth in SEQ ID NO: 1. |
| FILED | Friday, May 01, 2020 |
| APPL NO | 17/608013 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/47 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1037 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348620 | Altieri et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Wistar Institute of Anatomy and Biology (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dario Altieri (Philadelphia, Pennsylvania); Young Chan Chae (Philadelphia, Pennsylvania); Jae Ho Seo (Philadelphia, Pennsylvania) |
| ABSTRACT | The present invention relates to Mitochondrial Fission Factor (MFF)-derived peptides or peptide mimetics and to methods of making MFF-derived peptides or peptide mimetics. Also provided are methods of treating a disease in a subject in need thereof, comprising administering to the subject an effective amount of a MFF-derived peptide or peptide mimetic. |
| FILED | Wednesday, September 09, 2020 |
| APPL NO | 17/641346 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/00 (20130101) A61K 38/1761 (20130101) Peptides C07K 14/4747 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348627 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF DARTMOUTH COLLEGE (HANOVER, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tong Zhang (Beijing, China PRC); Charles L. Sentman (West Lebanon, New Hampshire) |
| ABSTRACT | The present invention relates to chimeric immune receptor molecules for reducing or eliminating tumors. The chimeric receptors are composed a C-type lectin-like natural killer cell receptor, or a protein associated therewith, fused to an immune signaling receptor containing an immunoreceptor tyrosine-based activation motif. Methods for using the chimeric receptors are further provided. |
| FILED | Thursday, May 19, 2022 |
| APPL NO | 17/748683 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 38/10 (20130101) A61K 45/06 (20130101) Peptides C07K 14/705 (20130101) Original (OR) Class C07K 14/715 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348628 | ROYBAL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kole T. ROYBAL (San Francisco, California); Raymond LIU (San Francisco, California); Iowis ZHU (San Francisco, California) |
| ABSTRACT | The present disclosure generally relates to, among other things, a new class of receptors engineered to modulate transcriptional regulation in a ligand-dependent manner Particularly, the new receptors, even though derived from Notch and Robo, do not require the Notch or Robo regulatory regions previously believed to be necessary for the functioning of the receptors. The disclosure also provides compositions and methods useful for producing such receptors, nucleic acids encoding same, host cells genetically modified with the nucleic acids, as well as methods for modulating an activity of a cell and/or for the treatment of various health conditions such as diseases (e.g., cancers). |
| FILED | Wednesday, September 23, 2020 |
| APPL NO | 17/762687 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 38/00 (20130101) A61K 45/06 (20130101) Peptides C07K 14/705 (20130101) Original (OR) Class C07K 16/22 (20130101) C07K 16/28 (20130101) C07K 16/30 (20130101) C07K 16/2803 (20130101) C07K 16/2851 (20130101) C07K 16/2866 (20130101) C07K 16/2878 (20130101) C07K 16/3069 (20130101) C07K 16/3084 (20130101) C07K 16/3092 (20130101) C07K 2317/622 (20130101) C07K 2319/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348638 | Huang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The J. David Gladstone Institutes, a testamentary trust estabilished under the Will of J. David Glad (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yadong Huang (Danville, California); Kelly Zalocusky (Mountain View, California) |
| ABSTRACT | A method for reducing neuronal and synaptic degeneration or loss in a population of neuronal cells is provided as well as a method of treating an individual with a neurocognitive disorder. Aspects of the methods include modulating the level and/or activity of apolipoprotein E (apoE) in a population of neuronal cells where the modulating reduces the level and/or activity of an MHC pathway polypeptide in the population of neuronal cells. |
| FILED | Thursday, September 24, 2020 |
| APPL NO | 17/763424 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Peptides C07K 14/775 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348642 | Nussenzweig et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Rockefeller University (New York, New York); California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | The Rockefeller University (New York, New York); California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Michel Nussenzweig (New York, New York); Natalia T. Freund (New York, New York); Pamela J. Bjorkman (Altadena, California); Louise Scharf (Porter Ranch, California) |
| ABSTRACT | This invention relates to broadly neutralizing and potent anti-HIV-1 antibodies, kits, and methods of use thereof. |
| FILED | Wednesday, March 30, 2022 |
| APPL NO | 17/708763 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 39/21 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Peptides C07K 16/1045 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348644 | DELISA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew DELISA (Ithaca, New York); Jeffrey VARNER (Ithaca, New York); Alyse PORTNOFF (Ithaca, New York) |
| ABSTRACT | The present invention relates to an isolated chimeric molecule comprising a degradation domain including a eukaryotic U-box motif and a targeting domain capable of immunospecifically directing the degradation domain to a substrate where the targeting domain is heterologous to the degradation domain. A linker couples the degradation domain to the targeting domain. Also disclosed are compositions as well as methods of treating a disease, substrate silencing, screening agents for therapeutic efficacy against a disease, and methods of screening for disease biomarkers. |
| FILED | Tuesday, November 23, 2021 |
| APPL NO | 17/534048 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 16/00 (20130101) C07K 16/18 (20130101) Original (OR) Class C07K 2319/00 (20130101) C07K 2319/50 (20130101) C07K 2319/95 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/93 (20130101) Enzymes C12Y 603/02019 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348645 | LU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kun Ping LU (Newton, Massachusetts); Xiao Zhen ZHOU (Newton, Massachusetts) |
| ABSTRACT | Described are conformation-specific antibodies or antigen-binding fragments that specifically bind to the trans conformation of phosphorylated-Threonine254-Proline (pThr254-Pro) of the p65 subunit of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). Also described are related pharmaceutical compositions, polynucleotides, peptides, vectors, host cells, methods of production, methods of treatment, diagnostic methods, and kits. |
| FILED | Thursday, October 01, 2020 |
| APPL NO | 17/765514 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/3955 (20130101) A61K 45/06 (20130101) A61K 47/6803 (20170801) A61K 47/6843 (20170801) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 16/18 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) G01N 2333/4703 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348648 | POIRIER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Memorial Sloan Kettering Cancer Center (New York, New York); TRI-INSTITUTIONAL THERAPEUTICS DISCOVERY INSTITUTE (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John T. POIRIER (New York, New York); Charles RUDIN (New York, New York); Jason LEWIS (New York, New York); Abdul KHAN (New York, New York); David ANDREW (New York, New York); Xinlei CHEN (New York, New York); Ivo LORENZ (New York, New York) |
| ABSTRACT | The present disclosure relates generally to immunoglobulin-related compositions (e.g., antibodies or antigen binding fragments thereof) that can bind to delta-like protein 3 (DLL3). The antibodies of the present technology are useful in methods for detecting and treating a DLL3-associated cancer in a subject in need thereof. |
| FILED | Wednesday, July 08, 2020 |
| APPL NO | 17/622404 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/28 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/51 (20130101) C07K 2317/55 (20130101) C07K 2317/515 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348656 | SCHWABE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alector LLC (South San Francisco, California) |
| ASSIGNEE(S) | Alector LLC (South San Francisco, California) |
| INVENTOR(S) | Tina SCHWABE (San Francisco, California); Michael KURNELLAS (San Francisco, California); Arnon ROSENTHAL (Woodside, California); Robert PEJCHAL (Lebanon, New Hampshire); Anthony B. COOPER (White River Junction, Vermont) |
| ABSTRACT | The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, affinity-matured, humanized antibodies, antibody fragments, etc., that specifically bind a Sortilin protein, e.g., human Sortilin or mammalian Sortilin, and have improved and/or enhanced functional characteristics, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof. |
| FILED | Thursday, June 09, 2022 |
| APPL NO | 17/836707 |
| CURRENT CPC | Peptides C07K 16/286 (20130101) Original (OR) Class C07K 2317/31 (20130101) C07K 2317/52 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/94 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348677 | ROYBAL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kole T. ROYBAL (Oakland, California); Raymond LIU (Oakland, California); Iowis ZHU (Oakland, California) |
| ABSTRACT | The present disclosure generally relates to, among other things, a new class of receptors engineered to modulate transcriptional regulation in a ligand-dependent manner. In particular, the new receptors contain a heterologous transmembrane domain comprising at least one γ-secretase site. The disclosure also provides compositions and methods useful for producing such receptors, nucleic acids encoding same, host cells genetically modified with the nucleic acids, as well as methods for modulating an activity of a cell and/or for the treatment of various health conditions or diseases, such as cancers. |
| FILED | Wednesday, September 23, 2020 |
| APPL NO | 17/763116 |
| CURRENT CPC | Peptides C07K 14/4705 (20130101) C07K 16/2896 (20130101) Original (OR) Class C07K 2317/622 (20130101) C07K 2319/03 (20130101) C07K 2319/035 (20130101) C07K 2319/71 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348680 | Pasqualini et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Renata Pasqualini (New Brunswick, New Jersey); Wadih Arap (New Brunswick, New Jersey); Fernanda Iamassaki Staquicini (New Brunswick, New Jersey); Fortunato Ferrara (Santa Fe, New Mexico); Sara D'Angelo (Santa Fe, New Mexico); Andrew R.M. Bradbury (Santa Fe, New Mexico) |
| ABSTRACT | Isolated or recombinant EphA5 or GRP78 targeting antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer. A method of rapidly identifying antibodies or antibody fragments for the treatment of cancer using a combination of in vitro and in vivo methodologies is also provided. |
| FILED | Friday, June 10, 2022 |
| APPL NO | 17/837888 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/07 (20130101) A61K 39/3955 (20130101) A61K 39/39558 (20130101) A61K 47/6803 (20170801) A61K 47/6817 (20170801) A61K 47/6843 (20170801) A61K 47/6849 (20170801) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/18 (20130101) C07K 16/28 (20130101) C07K 16/30 (20130101) Original (OR) Class C07K 16/2866 (20130101) C07K 16/3023 (20130101) C07K 2317/21 (20130101) C07K 2317/35 (20130101) C07K 2317/55 (20130101) C07K 2317/73 (20130101) C07K 2317/77 (20130101) C07K 2317/622 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1037 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57423 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348689 | MA |
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| FUNDED BY |
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| APPLICANT(S) | THE NEMOURS FOUNDATION (Jacksonville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhengyu MA (Garnet Valley, Pennsylvania) |
| ABSTRACT | A chimeric antigen receptor specific for the extracellular membrane-proximal domain (EMPD) of membrane-bound IgE (mIgE) is provided. The EMPD-specific chimeric antigen receptor comprises an extracellular ligand binding domain capable of binding EMPD, a transmembrane domain, and an intracellular domain that mediates T cell activation upon EMPD binding. Nucleic acids and vectors encoding the EMPD-specific chimeric antigen receptor are provided. T cells transduced with such vectors find use in chimeric antigen receptor -based adoptive T-cell therapy for targeting IgE-expressing B cells and treating IgE-mediated allergic diseases. |
| FILED | Monday, July 11, 2022 |
| APPL NO | 17/811657 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/08 (20180101) Peptides C07K 16/28 (20130101) C07K 16/4291 (20130101) Original (OR) Class Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/09 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348869 | Gabrilovich |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Wistar Institute of Anatomy and Biology (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dmitry I. Gabrilovich (Villanova, Pennsylvania) |
| ABSTRACT | Provided herein are methods of generating MDSCs ex vivo. The methods include culturing blood cells with an LRP2 agonist. |
| FILED | Wednesday, July 01, 2020 |
| APPL NO | 17/623978 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/14 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0634 (20130101) Original (OR) Class C12N 2500/24 (20130101) C12N 2501/22 (20130101) C12N 2501/385 (20130101) C12N 2501/2306 (20130101) C12N 2506/1353 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348870 | Blazar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota); Regents of the University of Michigan (Ann Arbor, Michigan); The Ohio State University (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bruce R. Blazar (Golden Valley, Minnesota); Keli Hippen (Minneapolis, Minnesota); Pavan Reddy (Ann Arbor, Michigan); Yaping Sun (Ann Arbor, Michigan); Ramiro Garzon (Columbus, Ohio) |
| ABSTRACT | This disclosure provides miRNA/mRNA pairs that can be used to increase the efficacy of T cells or to down-modulate T cell efficacy and restore equilibrium. |
| FILED | Wednesday, July 13, 2022 |
| APPL NO | 17/863558 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/06 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) Original (OR) Class C12N 5/0637 (20130101) C12N 15/113 (20130101) C12N 2310/113 (20130101) C12N 2320/32 (20130101) C12N 2501/65 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348877 | Wu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph C. Wu (Stanford, California); Hao Zhang (Stanford, California) |
| ABSTRACT | Human cardiac fibroblasts obtained from induced pluripotent stem cells (iPS cells) are provided for use in analysis, screening programs, and the like. |
| FILED | Friday, June 26, 2020 |
| APPL NO | 17/621453 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0656 (20130101) Original (OR) Class C12N 5/0657 (20130101) C12N 2501/15 (20130101) C12N 2501/115 (20130101) C12N 2503/02 (20130101) C12N 2506/45 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348888 | Estes et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Baylor College of Medicine (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mary K. Estes (Houston, Texas); David Graham (Houston, Texas); Robert Legare Atmar (Houston, Texas); Sue Ellen Crawford (Conroe, Texas); Khalil Ettayebi (Pearland, Texas); Kosuke Murakami (Houston, Texas) |
| ABSTRACT | Embodiments of the disclosure concern systems, methods, and/or compositions for cultivation of mammalian viruses, including at least human noroviruses and sapoviruses within the Caliciviridae family of viruses. The ex vivo culture systems include intestinal enteroids in combination with bile or a functionally active fraction or component thereof. In specific embodiments, the culture system is utilized to test inactivation compounds for therapeutic or environmental efficacy and to test contaminated comestibles and/or environmental entities for determination of the presence of infectious virus. Furthermore, antiviral compositions may be tested using systems of the disclosure, including drugs, small molecule inhibitors, and biologics such as neutralizing monoclonal antibodies. |
| FILED | Friday, July 08, 2022 |
| APPL NO | 17/811479 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/575 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0018 (20130101) C12N 5/0679 (20130101) C12N 7/00 (20130101) C12N 7/02 (20130101) Original (OR) Class C12N 2770/16051 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/569 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348906 | HARKINS KINCAID et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Claret Bioscience, LLC (Santa Cruz, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kelly M. HARKINS KINCAID (Santa Cruz, California); Colin Patrick NAUGHTON (Santa Cruz, California); Varsha RAO (Santa Cruz, California); Christopher J. TROLL (Santa Cruz, California); Joshua D. KAPP (Santa Cruz, California) |
| ABSTRACT | The technology relates in part to methods and compositions for analyzing nucleic acid. In some aspects, the technology relates to methods and compositions for preparing a nucleic acid library from single-stranded nucleic acid fragments. |
| FILED | Thursday, April 02, 2020 |
| APPL NO | 17/440386 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1068 (20130101) C12N 15/1093 (20130101) Original (OR) Class C12N 2330/31 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6869 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348912 | MELLO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Craig MELLO (Barrington, Rhode Island); Krishna Sumanth GHANTA (Grafton, Massachusetts) |
| ABSTRACT | The disclosure provides novel methods and compositions for gene editing. In particular, the disclosure relates to compositions and methods of making nucleic acid donor templates for highly efficient and precise gene editing. |
| FILED | Friday, June 19, 2020 |
| APPL NO | 17/620437 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/111 (20130101) Original (OR) Class C12N 15/902 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348921 | Patel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Baylor College of Medicine (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vivekkumar B. Patel (Houston, Texas); Hongran Wang (Houston, Texas); Vivek P. Singh (Houston, Texas); Erin Lynn Reineke (Houston, Texas); Megumi Mathison (Houston, Texas); Austin J. Cooney (Houston, Texas); Todd Rosengart (Houston, Texas) |
| ABSTRACT | Embodiments of the disclosure include methods and compositions for in situ cardiac cell regeneration, including transdifferentiation of cardiac cells to cardiomyocytes. In particular embodiments, in situ cardiac cell regeneration encompasses delivery of p63 shRNA and one or both of Hand2 and myocardin, and in specific embodiments further includes one or more of Gata4, Mef2c, and Tbx5. In specific aspects of the disclosure, adult cardiac fibroblasts are reprogrammed into cardiomyocytes using viral vectors that harbor p63 shRNA and one or both of the transcription factors Hand2 and myocardin. |
| FILED | Tuesday, July 19, 2022 |
| APPL NO | 17/813493 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/47 (20130101) A61K 31/713 (20130101) A61K 38/1709 (20130101) A61K 48/0058 (20130101) Peptides C07K 14/82 (20130101) C07K 14/4702 (20130101) C07K 14/4746 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0657 (20130101) C12N 15/86 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 15/1135 (20130101) C12N 2310/14 (20130101) C12N 2310/531 (20130101) C12N 2320/31 (20130101) C12N 2501/60 (20130101) C12N 2710/10043 (20130101) C12N 2740/15043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348930 | HECZEY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Baylor College of Medicine (Houston, Texas) |
| ASSIGNEE(S) | Baylor College of Medicine (Houston, Texas) |
| INVENTOR(S) | Andras HECZEY (Houston, Texas); Bin LIU (Richmond, Texas); Leonid METELITSA (Sugar Land, Texas) |
| ABSTRACT | The present disclosure provides methods and compositions related to Natural Killer T cells that are engineered to knock down the expression of one or more endogenous major histocompatibility complex (MHC) gene. The present disclosure also provides engineered CAR NKT cells that resist rejection by allogeneic immune cells both in vitro and in vivo. |
| FILED | Friday, April 22, 2022 |
| APPL NO | 17/727528 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 37/06 (20180101) Peptides C07K 14/55 (20130101) C07K 14/5443 (20130101) C07K 16/303 (20130101) C07K 16/2803 (20130101) C07K 16/3084 (20130101) C07K 2317/76 (20130101) C07K 2319/33 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0646 (20130101) C12N 15/1138 (20130101) Original (OR) Class C12N 2310/122 (20130101) C12N 2310/141 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348957 | Chien et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America as represented by the Secretary, Department of health and Human Svcs, (Rockville, Maryland); The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | The United States of America as represented by the Secretary, Department of health and Human Svcs. (Rockville, Maryland); The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Wade W. Chien (Bethesda, Maryland); Jean Bennett (Philadelphia, Pennsylvania) |
| ABSTRACT | Provided herein are adeno-associated viruses and methods for using same to treat or prevent disorders that affect the inner ear of a subject. |
| FILED | Friday, January 22, 2021 |
| APPL NO | 17/435365 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/16 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 2750/14122 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348959 | Balachandran et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Institute For Cancer Research d/b/a The Research Institute Of Fox Chase Cancer Center (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Siddharth Balachandran (Philadelphia, Pennsylvania); Roshan Thapa (Philadelphia, Pennsylvania) |
| ABSTRACT | RNA virus vectors comprising a gene encoding the DNA-dependent activator of interferon-regulatory factors (DAI) protein, and optionally further comprising a gene encoding the receptor-interacting serine; threonine-protein kinase 3 (RIPK3) may be used therapeutically to induce cell death, as well as an inflammatory immune response, against tumors and virally-infected cells. |
| FILED | Monday, April 18, 2022 |
| APPL NO | 17/723119 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) A61K 2039/585 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/04 (20180101) Peptides C07K 14/47 (20130101) C07K 14/4705 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/12 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 2760/16121 (20130101) C12N 2760/16132 (20130101) C12N 2760/16143 (20130101) Enzymes C12Y 207/11001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348966 | AVALOS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey); Massachusetts Institute of Technology (Cambridge, Massachusetts); Whitehead Institute for Biomedical Research (Cambridge, Massachusetts); Kyoto University (Kyoto, Japan) |
| ASSIGNEE(S) | The Trustees of Princeton University (Princeton, New Jersey); Massachusetts Institute of Technology (Cambridge, Massachusetts); Whitehead Institute for Biomedical Research (Cambridge, Massachusetts); Kyoto University (Kyoto, Japan) |
| INVENTOR(S) | José L. AVALOS (Princeton, New Jersey); Sarah K. HAMMER (Philadelphia, Pennsylvania); Kouichi KURODA (Kyoto, Japan); Gerald R. FINK (Cambridge, Massachusetts); Gregory STEPHANOPOULOS (Winchester, Massachusetts) |
| ABSTRACT | A method for producing metabolites that are heavy alcohols, and particularly branched-chain alcohols is provided, involving contacting a suitable substrate with recombinant microorganisms. The microorganisms contain at least one deletion, disruptions, or mutations from the GLN gene family, VPS gene family, GNP gene family, AVT gene family, GCN gene family, or YDR391C, and combinations thereof, and overproduce the heavy alcohol as compared to a wild-type yeast strain. |
| FILED | Friday, September 25, 2020 |
| APPL NO | 17/763773 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/185 (20210501) C12N 15/81 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/04 (20130101) Original (OR) Class C12P 7/22 (20130101) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/865 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348974 | ALMO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ALBERT EINSTEIN COLLEGE OF MEDICINE (Bronx, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven C. ALMO (Pelham, New York); Tyler GROVE (Bronx, New York) |
| ABSTRACT | A recombinant microorganism includes a transgene encoding a polypeptide of a Type II biotin synthase, wherein a holo-protein of the Type II biotin synthase comprises per polypeptide chain a first [4Fe—4S] cluster (radical SAM (RS) cluster) coordinated to a CxxxCxxC motif in the polypeptide chain and a second [4Fe—4S] cluster. The Type II biotin synthase contains a serine to cysteine swap in its holo-protein amino acid sequence, that is the amino acid at the position corresponding to Ser-43 in the E. coli K12 Type I biotin synthase holo-protein is a Cysteine and the amino acid corresponding to Cys-97 in the E. coli K12 Type I biotin synthase holo-protein is a Serine. A method for producing biotin includes cultivating the recombinant microorganism in a growth medium to produce a culture; and recovering biotin from the culture. |
| FILED | Friday, September 04, 2020 |
| APPL NO | 17/641319 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/13 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 17/186 (20130101) Original (OR) Class Enzymes C12Y 208/01006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348981 | Gelb et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Michael H. Gelb (Seattle, Washington); Xinying Hong (Seattle, Washington) |
| ABSTRACT | Methods, reagents, and kits for assaying for arylsulfatase A activity for diagnosing conditions associated with arylsulfatase A deficiency, such as multiple sulfatase deficiency (MSD) and metachromatic leukodystrophy (MILD). |
| FILED | Friday, September 18, 2020 |
| APPL NO | 17/762324 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/44 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2800/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348985 | Mirkin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chad A. Mirkin (Wilmette, Illinois); Sasha B. Ebrahimi (Dekalb, Illinois); Devleena Samanta (Evanston, Illinois); Ho Fung Cheng (Evanston, Illinois) |
| ABSTRACT | The present disclosure is directed to aptamers comprising a detectable marker situated at an internal location within the aptamer, use of the aptamers to, e.g., detect target analytes, and methods of making the aptamers. In exemplary embodiments, methods of the disclosure comprise contacting the target analyte with an aptamer comprising a detectable marker situated at an internal location within the aptamer, wherein the contacting results in binding of the target analyte to the aptamer, wherein target analyte binding to the aptamer results in restriction of internal rotation of the marker, resulting in a detectable change in the marker. |
| FILED | Friday, June 19, 2020 |
| APPL NO | 17/621088 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6804 (20130101) Original (OR) Class C12Q 1/6816 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348990 | Kishi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Jocelyn Yoshiko Kishi (Cambridge, Massachusetts); Thomas E. Schaus (Cambridge, Massachusetts); Peng Yin (Cambridge, Massachusetts); Feng Xuan (Cambridge, Massachusetts); Nikhil Gopalkrishnan (Cambridge, Massachusetts); Sungwook Woo (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure provides, in some aspects, nucleic acid-based molecular tools that enable the recording of molecular structure and soluble signals as well as the programmed assembly of molecular structures. |
| FILED | Thursday, February 03, 2022 |
| APPL NO | 17/592435 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/64 (20130101) C12N 15/113 (20130101) C12N 2310/122 (20130101) C12N 2310/127 (20130101) C12N 2330/50 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6809 (20130101) C12Q 1/6811 (20130101) Original (OR) Class C12Q 1/6825 (20130101) C12Q 1/6853 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348995 | Rao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Children's Medical Center Corporation (Boston, Massachusetts); The United States of America, As Represented by the Secretary, Department of Health and Human Services (Bethesda, Massachusetts) |
| ASSIGNEE(S) | The Children's Medical Center Corporation (Boston, Massachusetts); The United States of America, As Represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Anjana Rao (La Jolla, California); Mamta Tahiliani (New York, New York); Kian Peng Koh (Jamaica Plain, Massachusetts); Suneet Agarwal (Belmont, Massachusetts); Aravind Iyer (Bethesda, Maryland) |
| ABSTRACT | The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation. |
| FILED | Friday, February 18, 2022 |
| APPL NO | 17/675502 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1007 (20130101) C12N 2501/70 (20130101) C12N 2501/71 (20130101) C12N 2501/724 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/26 (20130101) C12Q 1/6806 (20130101) C12Q 1/6827 (20130101) Original (OR) Class C12Q 1/6869 (20130101) C12Q 2521/531 (20130101) C12Q 2522/10 (20130101) C12Q 2537/164 (20130101) C12Q 2600/154 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5308 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220349599 | Hematti et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peiman Hematti (Middleton, Wisconsin); John A. Kink (Madison, Wisconsin); Christian Capitini (Madison, Wisconsin) |
| ABSTRACT | The disclosure relates to an ex vivo generated population of educated macrophages specific to LPS and methods of making and using such macrophages. |
| FILED | Tuesday, July 12, 2022 |
| APPL NO | 17/863363 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0645 (20130101) C12N 5/0656 (20130101) C12N 5/0663 (20130101) Air-conditioning; Air-humidification; Ventilation; Use of Air Currents for Screening F24F 11/30 (20180101) Original (OR) Class F24F 11/50 (20180101) F24F 2110/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220349792 | FERRACANE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | OREGON HEALTH and SCIENCE UNIVERSITY (Portland, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jack FERRACANE (Portland, Oregon); Carmem PFEIFER (Portland, Oregon); Rafael Tiago PATZLAFF (Luzerna-Santa Catarina, Brazil) |
| ABSTRACT | A compact material testing system is configured to expose multiple samples housed within separate sample chambers to simulated fluid, thermal, and mechanical loading conditions. The system includes multiple independent load actuators positioned to extend actuator rods into corresponding sample chambers to apply mechanical loading to the test sample within. A fluid control system is included to bathe each test sample in a fluid medium and replenish the fluid medium within its sample chamber as needed. Each sample chamber includes a gas inlet and gas outlet to provide non-turbulent circulation and control of atmospheric composition above the fluid medium inside the chamber. A logic programmable controller is provided for input of test parameters and automated simultaneous control of mechanical loading, fluid flow, and temperature in the sample chambers. |
| FILED | Thursday, April 21, 2022 |
| APPL NO | 17/660204 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 3/12 (20130101) Original (OR) Class G01N 2203/0044 (20130101) G01N 2203/0208 (20130101) G01N 2203/0226 (20130101) G01N 2203/0242 (20130101) G01N 2203/0676 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220349880 | Li et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Kansas State University Research Foundation (Manhattan, Kansas); United States of America as Represented by the Administrator of NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jun Li (Manhattan, Kansas); Duy H. Hua (Manhattan, Kansas); Morgan James Anderson (Moffett Field, California); Jessica Erin Koehne (Moffett Field, California); Meyya Meyyappan (Moffett Field, California) |
| ABSTRACT | An electrochemical method for measuring the activity of biomarkers using microelectrode arrays functionalized with peptide consensus sequences and redox reporter moieties. Contact of the arrays with a biological sample containing one or more target biomarkers results in cleavage of the peptides and changes the electric current across the array in a quantifiable manner indicating not just the presence of the target biomarker in the sample, but its activity. |
| FILED | Tuesday, April 26, 2022 |
| APPL NO | 17/729494 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5438 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220349890 | Cance |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William G. Cance (Phoenix, Arizona) |
| ABSTRACT | The present invention relates to a method of using Focal Adhesion Kinase (FAX) as a predictive marker to identify patients with early-stage colorectal cancer (CRC) at risk for recurrence. In particular, the present invention is a prognostic assay using FAK protein expression to predict those CRC patients with Stage I disease who may recur. The present invention will allow for quantitative measurement of the expression of FAK in tumor tissue of patients with early-stage CRC. As patients with stage I CRC are typically only treated with surgical resection, the present invention will uniquely facilitate the identification of those early-stage CRC patients who are at risk of recurrence and who may benefit from adjuvant therapy after resection of the primary cancer. This invention is not limited to patients with CRC and may be utilized for any condition that is caused by or causes FAK overexpression or dysfunction. |
| FILED | Thursday, June 18, 2020 |
| APPL NO | 17/621123 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/68 (20130101) G01N 33/57419 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220349891 | Sun |
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| FUNDED BY |
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| APPLICANT(S) | Dali Sun (West Fargo, China PRC) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dali Sun (West Fargo, China PRC) |
| ABSTRACT | Provided are methods for identifying tumor-derived extracellular vesicles. The methods can include combining an antibody and a sample under conditions suitable for formation of antigen-antibody complexes with tumor-derived extracellular vesicles. The methods also include exposing the tumor-derived extracellular vesicles to a compound that binds beta-sheet structures, and determining if there is a change in binding of the compound to the extracellular vesicles compared to one or more controls. |
| FILED | Tuesday, May 03, 2022 |
| APPL NO | 17/735253 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1434 (20130101) G01N 33/57484 (20130101) Original (OR) Class G01N 2015/0065 (20130101) G01N 2333/705 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220349893 | ZHANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Wistar Institute of Anatomy and Biology (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | The Wistar Institute of Anatomy and Biology (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Rugang ZHANG (Philadelphia, Pennsylvania); Shuai WU (Philadelphia, Pennsylvania) |
| ABSTRACT | The present disclosure is directed to the use of inhibitors of glutamate metabolism to treat cancers that have mutations in ARID1A. Thus, in accordance with the present disclosure, there is provided a method of treating a subject determined to have an ARIDIA-mutated cancer, pre-cancer or benign tumor comprising administering to said subject at least one inhibitor of glutamate metabolism. |
| FILED | Friday, September 11, 2020 |
| APPL NO | 17/642512 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/155 (20130101) A61K 31/501 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57496 (20130101) Original (OR) Class G01N 2333/4703 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220349971 | Ma et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio); University College Cardiff Consultants Limited (Cardiff, United Kingdom) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dan Ma (Solon, Ohio); Mark A. Griswold (Shaker Heights, Ohio); Derek Jones (Cardiff, United Kingdom); Maryam Afzall (Cardiff, United Kingdom); Lars Mueller (Cardiff, United Kingdom) |
| ABSTRACT | A method for multi-dimensional, relaxation-diffusion magnetic resonance fingerprinting (MRF) includes performing, using a magnetic resonance imaging (MRI) system, a pulse sequence that integrates free-waveform b-tensor diffusion encoding into a magnet resonance fingerprinting pulse sequence to perform a multi-dimensional, relaxation-diffusion encoding while acquiring MRF signal evolutions, processing, using a processor, the acquired MRF signal evolutions to determine at least one relaxation parameter and at least one diffusivity parameter, and generating, using the processor, a report including at least one of the at least one relaxation parameter and the at least diffusivity parameter. |
| FILED | Monday, May 02, 2022 |
| APPL NO | 17/661736 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/50 (20130101) Original (OR) Class G01R 33/5608 (20130101) G01R 33/56341 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220349972 | Ma et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dan Ma (Solon, Ohio); Chaitra Badve (Moreland Hills, Ohio); Walter Zhao (Cleveland Heights, Ohio) |
| ABSTRACT | Automated processing and radiomic analysis of magnetic resonance imaging (“MRI”), such as multi-contrast MR images, and magnetic resonance fingerprinting (“MRF”) data, such as quantitative parameter maps, are integrated into a single workflow. |
| FILED | Monday, May 02, 2022 |
| APPL NO | 17/661661 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/5601 (20130101) G01R 33/5608 (20130101) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 15/00 (20180101) G16H 30/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220350137 | Chung et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Jae-Hyun Chung (Seattle, Washington); Vigneshwar Sakthivelpathi (Seattle, Washington); Sang-gyeun Ahn (Seattle, Washington) |
| ABSTRACT | An eye-tracking system, including at least one vertical capacitance sensor, configured to measure the vertical position of a cornea of a user's eye by sensing a position of an eyelid of the user; and at least one horizontal capacitance sensor, configured to measure the horizontal position of the cornea of the user's eye by sensing a position of the user's eyeball. |
| FILED | Friday, April 22, 2022 |
| APPL NO | 17/727644 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/113 (20130101) Optical Elements, Systems, or Apparatus G02B 27/0093 (20130101) Original (OR) Class G02B 27/0101 (20130101) G02B 2027/0132 (20130101) G02B 2027/0187 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220351829 | XIA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE METHODIST HOSPITAL SYSTEM (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Jiong XIA (Houston, Texas); Jaime GATENO (Bellaire, Texas); Peng YUAN (Princeton, New Jersey); Han DENG (Houston, Texas) |
| ABSTRACT | Methods and systems for establishing dental occlusion are described herein. These systems and methods can be used for 1-, 2-, or 3-piece maxillary orthognathic surgeries. An example computer-implemented method includes receiving a maxillary dental model and a mandibular dental model, identifying a plurality of dental landmarks in each of the maxillary and mandibular dental models, and extracting a plurality of points-of-interest from each of the maxillary and mandibular dental models. The dental landmarks include a plurality of maxillary dental landmarks and a plurality of mandibular dental landmarks. The method further includes aligning the maxillary and mandibular points-of-interest, and fine tuning the alignment of the maxillary and mandibular dental models to achieve maximum contact with a collision constraint. |
| FILED | Monday, October 12, 2020 |
| APPL NO | 17/765880 |
| CURRENT CPC | Dentistry; Apparatus or Methods for Oral or Dental Hygiene A61C 13/34 (20130101) A61C 19/05 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/40 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20220346717 | Nguyen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Quan Nguyen (Pomona, California); Avery Lee Goss (Pelham, New Hampshire); Conor Lee Evans (Charlestown, Pennsylvania); Lilian Witthauer (Flueh, Switzerland); Matthias Muller (Bonndorf, Germany) |
| ABSTRACT | Systems and methods for tourniquet monitoring and control is provided. A system includes at least one sensor, a housing, a processor, and a user communication module. The at least one sensor is configured to monitor at least one of deployment or operation of the tourniquet. The housing is configured to removably engage the tourniquet to position the at least one sensor to monitor the at least one of deployment or operation of the tourniquet. The processor is configured to receive feedback from the at least one sensor, compare the feedback to at least one of deployment or operation parameters for the tourniquet, and generate a user report. The user communication module is configured to communicate the user report. |
| FILED | Friday, August 07, 2020 |
| APPL NO | 17/633521 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/01 (20130101) A61B 5/685 (20130101) A61B 5/746 (20130101) A61B 5/6831 (20130101) A61B 5/6843 (20130101) Original (OR) Class A61B 5/14551 (20130101) A61B 2505/01 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220346818 | Faleris et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Axogen Corporation (Alachua, Florida) |
| ASSIGNEE(S) | Axogen Corporation (Alachua, Florida) |
| INVENTOR(S) | Jennifer Faleris (Alachua, Florida); Anne Engemann (Alachua, Florida); Curt Deister (Alachua, Florida) |
| ABSTRACT | A capture-tool for manipulation of tissue utilizes vacuum to hold the tissue in place. An extension attached to a vacuum source at one end and a vacuum arm at another end creates a vacuum force through the extension and vacuum arm. The vacuum arm has a support surface with ports therein at which low pressure areas are formed by the vacuum force. The low pressure areas draw tissue against the supporting surface to hold it in place, as long as the vacuum force is active. |
| FILED | Thursday, July 07, 2022 |
| APPL NO | 17/811108 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/30 (20130101) Original (OR) Class A61B 17/1128 (20130101) A61B 2017/308 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220347281 | PEOPLES et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George E. PEOPLES (Spring Branch, Texas); Sathibalan PONNIAH (Columbia, Maryland) |
| ABSTRACT | The invention features methods to induce and maintain a protective cytotoxic T-lymphocyte response to a peptide of the HER2/neu oncogene, E75, with the effect of inducing and maintaining protective or therapeutic immunity against breast cancer in a patient in clinical remission. The methods comprise administering to the patient an effective amount of a vaccine composition comprising a pharmaceutically acceptable carrier, an adjuvant such as recombinant human GM-CSF, and the E75 peptide at an optimized dose and schedule. The methods further comprise administering an annual or semi-annual booster vaccine dose due to declining E75-specific T cell immunity. The invention also features vaccine compositions for use in the methods. |
| FILED | Wednesday, October 21, 2020 |
| APPL NO | 17/076635 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 38/179 (20130101) A61K 38/193 (20130101) A61K 39/00 (20130101) A61K 39/39 (20130101) A61K 39/001106 (20180801) Original (OR) Class A61K 2039/545 (20130101) A61K 2039/55522 (20130101) Peptides C07K 14/71 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220347286 | THOMAS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States, as Represented by the Secretary of the Army (Fort Detrick, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen J. THOMAS (Rockville, Maryland); Kenneth H. ECKELS (Rockville, Maryland); Joseph R. PUTNAK (Silver Spring, Maryland); Richard G. JARMAN, III (Frederick, Maryland); Rafael Antonio DE LA BARRERA (Washington, District of Columbia) |
| ABSTRACT | The disclosure generally provides a purified inactivated chikungunya virus (CHIKV), methods for producing the purified inactivated CHIKV, immunogenic compositions and vaccines comprising the purified inactivated CHIKV and methods for the prevention and/or treatment of infection by CHIKV. |
| FILED | Tuesday, June 28, 2022 |
| APPL NO | 17/851813 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class A61K 2039/5254 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2770/36134 (20130101) C12N 2770/36163 (20130101) C12N 2770/36164 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220347988 | Hodzic et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | USA as represented by the Secretary of the Army (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alma Hodzic (Sheffield, United Kingdom); Patrick James Smith (Chinley, United Kingdom) |
| ABSTRACT | A composite which comprises a first layer of a fibre reinforced polymer and a second layer of a fibre reinforced polymer, between which is an intervening layer comprising an array of thermoplastic islands. |
| FILED | Wednesday, June 29, 2022 |
| APPL NO | 17/853656 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 37/0025 (20130101) B29C 70/30 (20130101) B29C 70/34 (20130101) B29C 70/0035 (20210501) B29C 70/40 (20130101) B29C 70/42 (20130101) B29C 70/88 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2033/12 (20130101) Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 3/10 (20130101) B32B 5/00 (20130101) B32B 7/12 (20130101) B32B 27/28 (20130101) B32B 27/34 (20130101) B32B 27/36 (20130101) B32B 27/38 (20130101) B32B 27/285 (20130101) Original (OR) Class B32B 37/0076 (20130101) B32B 37/1292 (20130101) B32B 2255/10 (20130101) B32B 2255/26 (20130101) B32B 2260/023 (20130101) B32B 2260/046 (20130101) B32B 2262/02 (20130101) B32B 2262/10 (20130101) B32B 2262/065 (20130101) B32B 2262/067 (20130101) B32B 2262/101 (20130101) B32B 2262/106 (20130101) B32B 2262/0261 (20130101) B32B 2305/076 (20130101) B32B 2307/50 (20130101) B32B 2307/542 (20130101) B32B 2307/546 (20130101) B32B 2307/762 (20130101) B32B 2605/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348696 | Hancock et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Akita Innovations LLC (Billerica, Massachusetts) |
| ASSIGNEE(S) | Akita Innovations LLC (Billerica, Massachusetts) |
| INVENTOR(S) | Lawrence F. Hancock (North Andover, Massachusetts); Richard A. Minns (Arlington, Massachusetts) |
| ABSTRACT | Articles and methods related to the manufacture of polymers containing labile crosslinking moieties are generally described. |
| FILED | Wednesday, April 20, 2022 |
| APPL NO | 17/725280 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 8/50 (20130101) Original (OR) Class C08F 130/08 (20130101) C08F 228/02 (20130101) C08F 230/08 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 77/38 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348854 | Luro et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott Luro (Cambridge, Massachusetts); Burak Okumus (Cambridge, Massachusetts); Johan Paulsson (Cambridge, Massachusetts) |
| ABSTRACT | A microfluidic device comprises a cell flow layer and a control layer. The cell flow layer includes a growth channel, a collection channel, a plurality of bridge channels connecting the growth channel and the collection channel, a plurality of bridge valve portions, and a plurality of cell growth trenches coupled to the growth channel. The growth channel includes an inlet valve portion and an outlet valve portion controlling flow into and out of the growth channel. The collection channel includes an inlet valve portion and an outlet valve controlling flow into and out of the collection channel. The bridge valve portions control flow between the growth channel and the collection channel. The control layer includes a first control channel actuating the bridge valve portions and a second control channel actuating the inlet valve portions and the outlet valve portions of the growth channel and the collection channel. |
| FILED | Monday, June 22, 2020 |
| APPL NO | 17/620636 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/16 (20130101) Original (OR) Class C12M 47/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348859 | Whitener et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Keith E. Whitener (Alexandria, Virginia); Dhanya Haridas (Ashburn, Virginia); Jillian N. Lanese (Webster, New York); Woo-Kyung Lee (Vienna, Virginia) |
| ABSTRACT | A method of lithographic masking for spatially localized biochemical stimulus delivery, comprising the steps of providing a group of cells on a substrate, coating a layer of gelatin on a portion of the cells, creating a mask layer on a portion of the layer of gelatin on a portion of the cells, and creating an area of masked cells and an area of unmasked cells. Further, the method can include delivering a biochemical signal to the area of unmasked cells, removing the mask layer, and allowing the cells with the biochemical signal and the cells without the biochemical signal to interact freely. |
| FILED | Wednesday, April 06, 2022 |
| APPL NO | 17/714224 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/04 (20130101) C12M 23/20 (20130101) C12M 23/22 (20130101) C12M 23/38 (20130101) C12M 25/06 (20130101) C12M 35/02 (20130101) Original (OR) Class C12M 47/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348909 | Hochrein et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lisa Hochrein (Pasadena, California); Mikhail H. Hanewich-Hollatz (Pasadena, California); Zhewei Chen (Pasadena, California); Heyun Li (Pasadena, California); Shashank Gandhi (Pasadena, California); Marianne Bronner (Pasadena, California); Niles A. Pierce (Pasadena, California) |
| ABSTRACT | Programmable guide RNAs (gRNAs) play a central role in the CRISPR revolution sweeping biology and medicine by directing the function of a Cas protein effector to a target gene of choice. To achieve programmable control over regulatory scope, the activity of a conditional guide RNA (cgRNA) depends on the presence or absence of an RNA trigger, allowing for cell-selective regulation of CRISPR/Cas function. Unlike a standard gRNA, a cgRNA is programmable at multiple levels, with the target-binding sequence controlling the target of Cas activity (edit, silence, induce, or bind a gene of choice) and the trigger binding sequence controlling the scope of Cas activity. cgRNA mechanisms that are allosteric allow for independent design of the target and trigger sequences, providing the flexibility to select the regulatory target and scope independently. Disclosed herein are allosteric cgRNA mechanisms for both ON→OFF logic (conditional inactivation by an RNA trigger) and OFF→ON logic (conditional activation by an RNA trigger). Allosteric cgRNAs enable restriction of CRISPR/Cas function to a desired cell type, tissue, organ, or disease state. Allosteric cgRNAs provide a versatile platform for cell-selective and tissue-selective research tools, biotechnologies, diagnostics, and therapeutics. |
| FILED | Tuesday, January 25, 2022 |
| APPL NO | 17/584237 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) Original (OR) Class C12N 2310/15 (20130101) C12N 2310/20 (20170501) C12N 2310/344 (20130101) C12N 2310/531 (20130101) C12N 2310/532 (20130101) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348924 | LIU |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC. (Augusta, Georgia) |
| ASSIGNEE(S) | AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC. (Augusta, Georgia) |
| INVENTOR(S) | Hongyan LIU (Martinez, Georgia) |
| ABSTRACT | Bispecific aptamers having a first end that specifically binds to a first tumor specific marker, tumor antigen, or viral protein and a second end that specifically binds to a second tumor specific marker, tumor antigen, or viral protein are provide. The bispecific aptamers can be used to treat cancer or virally infected cells. Generally, the bispecific aptamers bind to two surface proteins, preferably different proteins, on the same cell. In a preferred embodiment the bispecific aptamers bind to two different tumor markers, tumor antigens, tumor specific proteins and combinations thereof. |
| FILED | Tuesday, April 12, 2022 |
| APPL NO | 17/719189 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/115 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348985 | Mirkin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chad A. Mirkin (Wilmette, Illinois); Sasha B. Ebrahimi (Dekalb, Illinois); Devleena Samanta (Evanston, Illinois); Ho Fung Cheng (Evanston, Illinois) |
| ABSTRACT | The present disclosure is directed to aptamers comprising a detectable marker situated at an internal location within the aptamer, use of the aptamers to, e.g., detect target analytes, and methods of making the aptamers. In exemplary embodiments, methods of the disclosure comprise contacting the target analyte with an aptamer comprising a detectable marker situated at an internal location within the aptamer, wherein the contacting results in binding of the target analyte to the aptamer, wherein target analyte binding to the aptamer results in restriction of internal rotation of the marker, resulting in a detectable change in the marker. |
| FILED | Friday, June 19, 2020 |
| APPL NO | 17/621088 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6804 (20130101) Original (OR) Class C12Q 1/6816 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348990 | Kishi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Jocelyn Yoshiko Kishi (Cambridge, Massachusetts); Thomas E. Schaus (Cambridge, Massachusetts); Peng Yin (Cambridge, Massachusetts); Feng Xuan (Cambridge, Massachusetts); Nikhil Gopalkrishnan (Cambridge, Massachusetts); Sungwook Woo (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure provides, in some aspects, nucleic acid-based molecular tools that enable the recording of molecular structure and soluble signals as well as the programmed assembly of molecular structures. |
| FILED | Thursday, February 03, 2022 |
| APPL NO | 17/592435 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/64 (20130101) C12N 15/113 (20130101) C12N 2310/122 (20130101) C12N 2310/127 (20130101) C12N 2330/50 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6809 (20130101) C12Q 1/6811 (20130101) Original (OR) Class C12Q 1/6825 (20130101) C12Q 1/6853 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220349005 | Mirkin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chad A. Mirkin (Wilmette, Illinois); Charles A. Figg (Evanston, Illinois) |
| ABSTRACT | The present disclosure is generally directed to methods for controlling the polymerization of metastable oligonucleotide hairpins using the hybridization chain reaction (HCR) by introducing one or more base pair mismatches in the hairpins. Control was achieved through the introduction of a base-pair mismatch in the duplex of the hairpins. The mismatch modification allows one to energetically differentiate initiation versus propagation events, leading to DNA oligomers up to 10-mers with degree of polymerization (DP) dispersity between 1.3 and 1.6. |
| FILED | Wednesday, August 19, 2020 |
| APPL NO | 17/634908 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6818 (20130101) C12Q 1/6876 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220349172 | LITTLEFIELD et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Woods Hole Oceanographic Institution (Woods Hole, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robin LITTLEFIELD (Falmouth, Massachusetts); Jeffrey Kaeli (Woods Hole, Massachusetts) |
| ABSTRACT | A stowable generator device including a housing defining at least one storage chamber having an opening. A closure element is configured to selectively cover and uncover the opening. Support structure is disposed within the storage chamber in a collapsed position and is selectively extendable through the opening into an expanded position when the closure element is moved away from the opening. At least one energy generating unit is connected to the support structure. The support structure and the generating unit are configured to reversibly stow inside the housing in the collapsed position. |
| FILED | Monday, May 02, 2022 |
| APPL NO | 17/734183 |
| CURRENT CPC | Containers for Storage or Transport of Articles or Materials, e.g Bags, Barrels, Bottles, Boxes, Cans, Cartons, Crates, Drums, Jars, Tanks, Hoppers, Forwarding Containers; Accessories, Closures, or Fittings Therefor; Packaging Elements; Packages B65D 85/68 (20130101) B65D 88/121 (20130101) General Building Constructions; Walls, e.g Partitions; Roofs; Floors; Ceilings; Insulation or Other Protection of Buildings E04B 1/344 (20130101) Original (OR) Class Wind Motors F03D 13/20 (20160501) Indexing Scheme Relating to Wind, Spring, Weight, Inertia or Like Motors, to Machines or Engines for Liquids Covered by Subclasses F03B, F03D and F03G F05B 2240/91 (20130101) Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 10/12 (20141201) H02S 30/20 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220349312 | Strock et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Technologies Corporation (Farmington, Connecticut) |
| ASSIGNEE(S) | Raytheon Technologies Corporation (Farmington, Connecticut) |
| INVENTOR(S) | Christopher W. Strock (Boothbay Harbor, Maine); Kevin W. Schlichting (South Glastonbury, Connecticut) |
| ABSTRACT | An article has a metallic substrate having a plurality of recesses. A first coating is at least at the recesses and has: a splatted layer; and a columnar layer atop the splatted layer. A second coating is away from the recesses and has: a columnar layer atop the substrate without an intervening splatted layer. |
| FILED | Monday, June 06, 2022 |
| APPL NO | 17/832853 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 4/01 (20160101) C23C 4/02 (20130101) C23C 4/11 (20160101) C23C 4/18 (20130101) C23C 4/073 (20160101) C23C 4/123 (20160101) C23C 4/129 (20160101) C23C 4/134 (20160101) C23C 4/137 (20160101) C23C 14/024 (20130101) C23C 14/30 (20130101) C23C 14/042 (20130101) C23C 14/083 (20130101) C23C 28/042 (20130101) C23C 28/3215 (20130101) Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/288 (20130101) Original (OR) Class F01D 9/02 (20130101) F01D 11/08 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/30 (20130101) F05D 2230/90 (20130101) F05D 2230/312 (20130101) F05D 2230/313 (20130101) F05D 2300/17 (20130101) F05D 2300/5023 (20130101) Generating Combustion Products of High Pressure or High Velocity, e.g Gas-turbine Combustion Chambers F23R 3/002 (20130101) F23R 3/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220349373 | Son et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Steven Son (West Lafayette, Indiana); Kyle Uhlenhake (Lafayette, Indiana); Diane Collard (West Lafayette, Indiana); Mateo Gomez (West Lafayette, Indiana) |
| ABSTRACT | An igniter system and method for igniting a propellant by an optical energy source. The igniter system including an igniter composite and a propellant. The igniter composite including a reactive component and a fluoropolymer. The propellant is coupled to the igniter composite. The igniter composite has a composition including nano-aluminum at ideal stoichiometry in polyvinylidene fluoride. The igniter composite is configured to achieve a sustained ignition from a wavelength emitted from the optical energy source. The wavelength is between around 250 nanometers to around 1100 nanometers. |
| FILED | Monday, February 28, 2022 |
| APPL NO | 17/682026 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Jet-propulsion Plants F02K 9/95 (20130101) Ignition, Other Than Compression Ignition, for Internal-combustion Engines; Testing of Ignition Timing in Compression-ignition Engines F02P 23/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220349417 | LINDERMAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States as represented by the Secretary of the Air Force (Rome, New York) |
| ASSIGNEE(S) | Government of the United States as represented by the Secretary of the Air Force (Rome, New York) |
| INVENTOR(S) | Mark H. LINDERMAN (Rome, New York); Qing WU (Manlius, New York); Dennis FITZGERALD (Sauquoit, New York) |
| ABSTRACT | An apparatus for a microprocessor computer system and method for configuring the same where said microprocessor computer system comprises a processor core and at least one hardware buffer FIFO with memory-mapped head and tail that handles data movement among the processor cores, networks, raw data input and outputs, and memory. The method for configuring said microprocessor computer system comprises utilizing a FIFO auxiliary processor to process said data traversing said hardware FIFO; utilizing said hardware FIFOs to efficiently pipe data through functional blocks; and utilizing a FIFO controller to perform DMA operations that include non-unit-stride access patterns and transfers among processor cores, networks, raw data input and outputs, memory, and other memory-mapped hardware FIFOs. |
| FILED | Monday, July 18, 2022 |
| APPL NO | 17/813123 |
| CURRENT CPC | Non-positive-displacement Pumps F04D 13/06 (20130101) F04D 29/10 (20130101) F04D 29/12 (20130101) F04D 29/046 (20130101) F04D 29/106 (20130101) F04D 29/108 (20130101) Original (OR) Class F04D 29/126 (20130101) F04D 29/128 (20130101) Indexing Scheme Relating to Wind, Spring, Weight, Inertia or Like Motors, to Machines or Engines for Liquids Covered by Subclasses F03B, F03D and F03G F05B 2240/50 (20130101) F05B 2240/57 (20130101) Shafts; Flexible Shafts; Elements or Crankshaft Mechanisms; Rotary Bodies Other Than Gearing Elements; Bearings F16C 33/741 (20130101) F16C 33/743 (20130101) Pistons; Cylinders; Sealings F16J 15/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220349498 | Donatelli et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | APG Vision LLC (Allison Park, Pennsylvania) |
| ASSIGNEE(S) | APG Vision LLC (Allison Park, Pennsylvania) |
| INVENTOR(S) | Gregory M. Donatelli (Hatboro, Pennsylvania); Christopher C. McGeary (Gibsonia, Pennsylvania); David M. McMeekin (Butler, Pennsylvania); Tyler William Dulaney (Greenville, Pennsylvania) |
| ABSTRACT | A ball mount assembly comprising a ball mount including a body having an opening and a base, the ball mount having an internal passage extending through the opening of the body in an axial direction of the ball mount; a compression fitting secured to the ball mount; and a sealing insert disposed in the internal passage of the ball mount, wherein the sealing insert is interposed between the compression fitting and the ball mount in the internal passage, and wherein the internal passage of the ball mount is defined by a first sidewall and a second sidewall. |
| FILED | Tuesday, April 26, 2022 |
| APPL NO | 17/729513 |
| CURRENT CPC | Pipes; Joints or Fittings for Pipes; Supports for Pipes, Cables or Protective Tubing; Means for Thermal Insulation in General F16L 3/16 (20130101) Original (OR) Class Installation of Electric Cables or Lines, or of Combined Optical and Electric Cables or Lines H02G 15/013 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220349687 | Thompson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Clayton A. Thompson (FOUNTAIN VALLEY, California); Paul Faucheux (Stafford, Virginia) |
| ABSTRACT | Provided is a blast-free alternative tool for breaching operations for the intended purpose of cutting metal, including rebar, steel cables, I-beams, thin walled containers, welding doors, and the like. The apparatus includes a flexible and cuttable tube containing metal oxide/metal (thermite) mixture, capable of being formed around a target material and of NONEL ignition. The apparatus can be used to cut, weld, or ignite target material. Protective caps are included with provisions to insert shock tube or time fuse to transmit ignition to first fire mix. A fire proof or flame retardant flexible outerwrap with adhesive (such as hydrogel) or malleable retention wires covers the cutting ribbon for heat and slag retention. In the preferred embodiment, the apparatus is issued/manufactured in rolls or precut lengths. |
| FILED | Friday, April 29, 2022 |
| APPL NO | 17/733081 |
| CURRENT CPC | Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 3/22 (20130101) Original (OR) Class F42B 3/087 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220349695 | Hellebrekers et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Tess Hellebrekers (Pittsburgh, Pennsylvania); Carmel Majidi (Pittsburgh, Pennsylvania) |
| ABSTRACT | A soft magnetic sensor comprising a soft material containing randomly distributed magnetic microparticles and a magnetometer that can estimate force and localize contact over a continuous area. A reference magnetometer can be used to filter motion and ambient noise. Methods for locating contact and determining force comprise data analysis of the magnetometer output. In some embodiments, the sensor can localize an object prior to contact. |
| FILED | Monday, June 22, 2020 |
| APPL NO | 17/621646 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 7/24 (20130101) Original (OR) Class Measuring Not Specially Adapted for a Specific Variable; Arrangements for Measuring Two or More Variables Not Covered in a Single Other Subclass; Tariff Metering Apparatus; Measuring or Testing Not Otherwise Provided for G01D 5/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220349991 | Owen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Kansas (Lawrence, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan William Owen (Lawrence, Kansas); Gerald Brandon Ravenscroft (Gardner, Kansas); Shannon D. Blunt (Shawnee, Kansas) |
| ABSTRACT | An ad hoc approach denoted as devoid clutter capture and filling (DeCCaF) that addresses the nonstationarity effects that arise when input radar waveform returns exhibiting dynamic spectra variations are processed to combat dynamic RFI is disclosed. Portions of the spectra of each input waveform return of a set of input radar waveform returns processed during the CPI may be filled with clutter information borrowed from other waveform returns of the set of waveform returns. DeCCaF may combined with an appropriate filter (e.g., a matched filter, a mismatched filter) to achieve results that are nearly indistinguishable from input radar waveform returns in which no spectral variation are present. |
| FILED | Monday, September 21, 2020 |
| APPL NO | 17/761391 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/0232 (20210501) Original (OR) Class G01S 7/288 (20130101) G01S 13/582 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220350009 | Sahin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Kansas (Lawrence, Kansas); Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cenk Sahin (Oakwood, Ohio); Patrick M. McCormick (Fairborn, Ohio); Justin G. Metcalf (Norman, Oklahoma); John Jakabosky (Alexandria, Virginia); Shannon David Biunt (Shawnee, Kansas); Erik S. Perrins (Lawrence, Kansas) |
| ABSTRACT | Systems, methods, and computer-readable storage media for generating and utilizing radar signals with embedded data are disclosed. Data is encoded onto a CPM waveform, which is then combined with a base radar waveform to produce a radar-embedded communication (REC) waveform. Both the CPM waveform and the base radar waveform may have a continuous phase and constant envelope, resulting in the REC waveform having a continuous phase and constant envelope. The changing (e.g., on a pulse-to-pulse basis) nature of the REC waveform causes RSM of clutter which may result in residual clutter after clutter cancellation, decreasing target detection performance of the radar system. In an aspect, various parameters may be utilized to dynamically adjust the performance of the radar system for a particular operating scenario, such as to enhance radar signal processing or enhance data communication capabilities. |
| FILED | Friday, September 18, 2020 |
| APPL NO | 17/761326 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/006 (20130101) G01S 13/325 (20130101) Original (OR) Class G01S 2013/9316 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220350031 | Lewis |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | US Gov't as represented by Sec'y of Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven Lewis (Colorado Springs, Colorado) |
| ABSTRACT | A transceiver system and methodology generate, monitor and detect changes in Global Navigation Satellite System (GNSS) interferometric reflectometry signatures as to provide defensive security for GNSS signals used for positioning, navigating, and timing applications. |
| FILED | Thursday, February 24, 2022 |
| APPL NO | 17/679657 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 19/20 (20130101) G01S 19/215 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220350054 | Korenstein et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | RAYTHEON COMPANY (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ralph Korenstein (Natick, Massachusetts); Christopher S. Nordahl (Chelmsford, Massachusetts) |
| ABSTRACT | According to various aspects and embodiments, a system and method for providing an optical element is disclosed. In one example, the optical element includes a substrate formed from a Nanocomposite Optical Ceramic (NCOC) material that includes a first oxide nanograin material dispersed in a second oxide nanograin material, and a compressive layer of the NCOC material formed on a surface of the substrate. |
| FILED | Thursday, July 07, 2022 |
| APPL NO | 17/859196 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/10 (20130101) C23C 14/35 (20130101) C23C 14/081 (20130101) C23C 14/082 (20130101) C23C 14/083 (20130101) C23C 14/086 (20130101) Weapon Sights; Aiming F41G 7/2253 (20130101) F41G 7/2293 (20130101) Optical Elements, Systems, or Apparatus G02B 1/14 (20150115) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220350057 | Guler et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Urcan Guler (Avon, Connecticut); Alberto Naldoni (Torino, Italy); Alexander V. Kildishev (West Lafayette, Indiana); Alexandra Boltasseva (West Lafayette, Indiana); Vladimir M. Shalaev (West Lafayette, Indiana) |
| ABSTRACT | A nanostructured material system for efficient collection of photo-excited carriers is provided. They system comprises a plurality of plasmonic metal nitride core material elements coupled to a plurality of semiconductor material elements. The plasmonic nanostructured elements form ohmic junctions at the surface of the semiconductor material or at close proximity with the semiconductor material elements. A nanostructured material system for efficient collection of photo-excited carriers is also provided, comprising a plurality of plasmonic transparent conducting oxide core material elements coupled to a plurality of semiconductor material elements. The field enhancement, local temperature increase and energized hot carriers produced by nanostructures of these plasmonic material systems play enabling roles in various chemical processes. They induce, enhance, or mediate catalytic activities in the neighborhood when excited near the resonance frequencies. |
| FILED | Thursday, July 07, 2022 |
| APPL NO | 17/859665 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 27/24 (20130101) B01J 35/004 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 20/00 (20130101) Treatment of Inorganic Materials, Other Than Fibrous Fillers, to Enhance Their Pigmenting or Filling Properties; Preparation of Carbon Black; C09C 1/3607 (20130101) Optical Elements, Systems, or Apparatus G02B 5/008 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/5268 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220350076 | COOLBAUGH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Research Foundation for The State University of New York (Albany, New York) |
| ASSIGNEE(S) | The Research Foundation for The State University of New York (Albany, New York) |
| INVENTOR(S) | Douglas COOLBAUGH (Albany, New York); Gerald L. LEAKE, JR. (Albany, New York) |
| ABSTRACT | There is set forth herein a photonics device. The photonics device can comprise a substrate, a conductive material formation, a dielectric stack, and a barrier layer. The photonics device can transmit a light signal. |
| FILED | Wednesday, June 29, 2022 |
| APPL NO | 17/809580 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/122 (20130101) Original (OR) Class G02B 6/136 (20130101) G02B 2006/12061 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/486 (20130101) H01L 21/76202 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220350082 | YANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lan YANG (St. Louis, Missouri); Guangming ZHAO (St. Louis, Missouri); Xuefeng JIANG (St. Louis, Missouri); Yihang LI (St. Louis, Missouri) |
| ABSTRACT | Optical whispering gallery mode (WGM) resonator-based acoustic sensors, imaging systems that make use of the acoustic sensors, and methods of detecting ultrasound waves using the acoustic sensors are disclosed. |
| FILED | Friday, September 18, 2020 |
| APPL NO | 17/761026 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0095 (20130101) A61B 8/565 (20130101) A61B 8/4444 (20130101) A61B 2562/0238 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/0654 (20130101) Optical Elements, Systems, or Apparatus G02B 6/29341 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220350876 | Vasudevan |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Amit Vasudevan (Pittsburgh, Pennsylvania) |
| ABSTRACT | Disclosed herein is a system architecture that structures commodity heterogeneous interconnected computing platforms around universal object abstractions, which are a fundamental system abstraction and building block that provides practical and provable end-to-end guarantees of security, correctness, and timeliness for the platform. |
| FILED | Tuesday, March 01, 2022 |
| APPL NO | 17/683786 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/4812 (20130101) G06F 11/3608 (20130101) G06F 21/44 (20130101) Original (OR) Class G06F 21/602 (20130101) G06F 2221/2141 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220351045 | Nugent |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alex Nugent (Santa Fe, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alex Nugent (Santa Fe, New Mexico) |
| ABSTRACT | Methods, systems and devices for unsupervised learning utilizing at least one kT-RAM. An evaluation can be performed over a group of N AHaH nodes on a spike pattern using a read instruction (FF), and then an increment high (RH) instruction can be applied to the most positive AHaH node among the N AHaH nodes if an ID associated with the most positive AHaH node is not contained in a set, followed by adding a node ID to the set. In addition, an increment low (RL) instruction can be applied to all AHaH nodes that evaluated positive but were not the most positive, contingent on the most-positive AHaH node's ID not being contained in the set. In addition, node ID's can be removed from the set if the set size is equal to the N number of AHaH nodes. |
| FILED | Tuesday, June 05, 2018 |
| APPL NO | 16/000161 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/049 (20130101) G06N 3/088 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220351885 | CUI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | HRL Laboratories, LLC (Malibu, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shanying CUI (Calabasas, California); Xin N. GUAN (Monterey Park, California); Adam F. GROSS (Santa Monica, California); Florian G. HERRAULT (Agoura Hills, California) |
| ABSTRACT | Some variations provide a magnetically anisotropic structure comprising a hexaferrite film disposed on a substrate, wherein the hexaferrite film contains a plurality of discrete and aligned magnetic hexaferrite particles, wherein the hexaferrite film is characterized by an average film thickness from about 1 micron to about 500 microns, and wherein the hexaferrite film contains less than 2 wt % organic matter. The hexaferrite film does not require a binder. Discrete particles are not sintered or annealed together because the maximum processing temperature to fabricate the structure is 500° C. or less, such as 250° C. or less. The magnetic hexaferrite particles may contain barium hexaferrite (BaFe12O19) and/or strontium hexaferrite (SrFe12O19). The hexaferrite film may be characterized by a remanence-to-saturation magnetization ratio of at least 0.7. Methods of making and using the magnetically anisotropic structure are also described. |
| FILED | Monday, February 28, 2022 |
| APPL NO | 17/682478 |
| CURRENT CPC | Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 1/348 (20130101) Original (OR) Class H01F 10/28 (20130101) H01F 10/30 (20130101) H01F 10/205 (20130101) H01F 41/24 (20130101) Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 1/38 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20220351902 — DIELECTRIC NANOLAYER CAPACITOR AND METHOD OF CHARGING A DIELECTRIC NANOLAYER CAPACITOR
| US 20220351902 | Bezryadin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexey Bezryadin (Urbana, Illinois); Eduard Ilin (Champaign, Illinois); Irina Burkova (Champaign, Illinois) |
| ABSTRACT | A dielectric nanolayer capacitor comprises a nanoscale dielectric layer between a cathode layer and an anode layer. When exposed to a high electric field of at least about 0.5 GV/m at a temperature of about 200 K or less, the nanoscale dielectric layer includes an amount of trapped charge sufficient to form a Coulomb barrier for suppressing leakage current. A method of charging a dielectric nanolayer capacitor includes cooling a nanolayer capacitor comprising a nanoscale dielectric layer between a cathode layer and an anode layer to a temperature of about 200 K or less, and applying a high electric field of at least about 0.5 GV/m to the nanolayer capacitor to inject electrons into the nanoscale dielectric layer. While the nanolayer capacitor remains cooled to the temperature, the electrons are trapped in the nanoscale dielectric layer and form a Coulomb barrier to suppress leakage current. |
| FILED | Wednesday, July 14, 2021 |
| APPL NO | 17/375251 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 4/06 (20130101) Original (OR) Class Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 7/345 (20130101) H02J 7/007182 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220352231 | Oskotsky et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BAE SYSTEMS Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| ASSIGNEE(S) | BAE SYSTEMS Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| INVENTOR(S) | Mark L. Oskotsky (Mamaroneck, New York); Thomas Altamura (Hicksville, New York); Daniel Engheben (Commack, New York); Morgan Jolley (Commack, New York); Christopher V. Lipari (Whitestone, New York); Vincent Lipari (Whitestone, New York); Jerry Ma (Flushing, New York); Michael J. Russo, JR. (Roslyn, New York); Yueli Zhang (Saint James, New York) |
| ABSTRACT | A Mid-Wave Infrared (MWIR) objective lens having an F # of 2.64 and a 33.6° angular field of view. It is deployed, with a focal plane and scanning system, on an airborne platform for remote sensing applications. Focal length is 9 inches, and the image is formed on a focal plane constituting CCD or CMOS with micro lenses. The lens has, from object to image, three optical element groups with a cold shield/aperture stop. Group 1 has a positive optical power and three optical elements; Group 2 has a positive optical power and four optical elements; Group 3 has a positive optical power and three optical elements. The objective lens is made of two Germanium and Silicon. The lens is both apochromatic and orthoscopic, and corrected for monochromatic and chromatic aberrations over 3.3 to 5.1 micrometers. |
| FILED | Friday, April 23, 2021 |
| APPL NO | 17/238477 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 3/0037 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/14627 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220352572 | Sloop |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | HULICO LLC (Bend, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven E. Sloop (Bend, Oregon) |
| ABSTRACT | Examples are disclosed of methods to recycle positive-electrode material of a lithium-ion battery. One example provides a method including relithiating the positive-electrode material in a solution comprising lithium ions and an oxidizing agent, and after relithiating, separating the positive-electrode material from the solution. |
| FILED | Monday, July 18, 2022 |
| APPL NO | 17/867472 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/54 (20130101) Original (OR) Class H01M 10/0525 (20130101) H01M 2004/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20220346702 | Bhatnagar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for The State of University New York (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Divya Bhatnagar (Stony Brook, New York); Miriam Rafailovich (Plainview, New York); Raphael Davis (Port Jefferson, New York); Alexander B. Dagum (Stony Brook, New York); Duc T. Bui (Dix Hills, New York) |
| ABSTRACT | The present invention pertains to methods of determining where, on the skin, a diagnostic, therapeutic, or cosmetic agent is likely to be most effectively applied (e.g., injected), and to methods for monitoring a patient after such an agent has been administered. The monitoring can produce information useful in determining whether a diagnostic, therapeutic (e.g., surgical), or cosmetic regime should be initiated, continued, continued in a modified fashion, or terminated (e.g., for a brief or prolonged period of time). The methods can be repeated periodically and use a non-invasive, in vivo form of digital image speckle correlation (DISC) to track deformation of the skin. |
| FILED | Monday, February 28, 2022 |
| APPL NO | 17/682839 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/442 (20130101) Original (OR) Class A61B 5/1107 (20130101) A61B 5/1128 (20130101) A61B 5/4041 (20130101) A61B 5/4839 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220346709 | Mittal et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland); Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rajat Mittal (Vienna, Virginia); Jung Hee Seo (Baltimore, Maryland); Lakshmi Prasad Dasi (Dublin, Ohio); Hoda Hatoum (Columbus, Ohio); Shantanu Bailoor (Baltimore, Maryland) |
| ABSTRACT | The present invention is directed to a system for monitoring the functional status of an implantable heart valve. The system includes wireless pressure sensors that are embedded in the implantable heart valve. An external device receives signal transmitted from the wireless pressure sensors. The external device reads and analyzes these signals and then transmits the data to a healthcare provider. |
| FILED | Monday, June 22, 2020 |
| APPL NO | 17/621531 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4851 (20130101) Original (OR) Class A61B 5/6862 (20130101) A61B 2562/0247 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/2418 (20130101) A61F 2250/0002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220346908 | Vipperman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh-Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); UPMC (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh-Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); UPMC (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Jeffrey S. Vipperman (Pittsburgh, Pennsylvania); Christopher Michael Dumm (Verona, Pennsylvania); Garth Abraham Elias (Pittsburgh, Pennsylvania); Tyler Michael Ferris (Canfield, Ohio); Mark Scaife (Pittsburgh, Pennsylvania); Peter David Allen (Pittsburgh, Pennsylvania) |
| ABSTRACT | Disclosed adjustable retaining arm systems can include a multi-segmented, articulable arm that holds one or more interchangeable tools and can be made relaxed to set a desired position and made rigid to fix the desired position by adjusting tension in a cable running through the arm. The arm can quickly attach and detach from a support structure. The support structure include a cable tensioning system, sensors, control system, power system, etc. A user input device, such as a foot pedal or button on the arm, can be used by a surgeon to change the arm between relaxed and rigid states. The arm and attachable tools can be detachable, disposable and/or sterilizable, while other system components can remain mounted in a fixed location as the arm is removed and replaced. The arm can hold multiple tools in any desired orientation around subject work location. |
| FILED | Monday, July 11, 2022 |
| APPL NO | 17/862078 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/02 (20130101) A61B 17/00234 (20130101) A61B 34/71 (20160201) A61B 90/30 (20160201) A61B 90/35 (20160201) A61B 90/50 (20160201) Original (OR) Class A61B 90/57 (20160201) A61B 90/361 (20160201) A61B 2017/0023 (20130101) A61B 2017/00486 (20130101) A61B 2017/00973 (20130101) A61B 2034/715 (20160201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220346956 | Criscione et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TEXAS A and M UNIVERSITY SYSTEM (College Station, Texas); CORINNOVA INCORPORATED (Houston, Texas) |
| ASSIGNEE(S) | THE TEXAS A and M UNIVERSITY SYSTEM (College Station, Texas); CORINNOVA INCORPORATED (Houston, Texas) |
| INVENTOR(S) | John C. Criscione (College Station, Texas); Lewis D. Harrison (Flower Mound, Texas); Michael R. Moreno (College Station, Texas); Christina M. Bolch (Houston, Texas); Dennis I. Robbins (Richardson, Texas); Saurabh Biswas (College Station, Texas); Boris Leschinsky (Mahwah, New Jersey) |
| ABSTRACT | The present invention provides methods, systems, kits, and cardiac compression devices that have both passive chambers and active chambers to improve heart function. |
| FILED | Monday, July 11, 2022 |
| APPL NO | 17/861581 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/2481 (20130101) Original (OR) Class Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 60/148 (20210101) A61M 60/191 (20210101) A61M 60/289 (20210101) A61M 60/468 (20210101) A61M 60/839 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220347468 | GARCIA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Kytopen Corporation (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paulo Andres GARCIA (Somerville, Massachusetts); Cullen BUIE (Cambridge, Massachusetts); Ross BEIGHLEY (Cambridge, Massachusetts); Rameech MCCORMACK (Cambridge, Massachusetts); James HEMPHILL (Medford, Massachusetts); Jessica SIDO (Alton, Illinois); Bethany GRANT (Scituate, Massachusetts) |
| ABSTRACT | Methods, devices, systems, and kits for electro-mechanical cell transfection are provided. A device includes a first electrode, a second electrode, and an active zone therebetween where an electrical potential difference applied to the first and second electrodes generates an electric field in the active zone sufficient to transfect at least a subset of the cells flowing in the active zone. |
| FILED | Wednesday, April 27, 2022 |
| APPL NO | 17/731112 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/327 (20130101) Original (OR) Class Apparatus for Enzymology or Microbiology; C12M 1/42 (20130101) C12M 35/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 13/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220347610 | Makin, III et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF WESTERN MICHIGAN UNIVERSITY (Kalamazoo, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Allen Makin, III (Kalamazoo, Michigan); Steven Michael Durbin (Kalamazoo, Michigan) |
| ABSTRACT | A process for predicting and adjusting particle removal efficiency of fiber-based filter media based on quantification of disorder. An order parameter may be extracted through Raman spectroscopy or scanning electron microscopy. Production processes may be adjusted to change (e.g., increase) the particle removal efficiency of fiber-based filter media utilizing a predefined correlation between order parameter and particle removal efficiency. The filter media may be utilized in masks, filters, and other applications. |
| FILED | Tuesday, May 03, 2022 |
| APPL NO | 17/735788 |
| CURRENT CPC | Separation B01D 39/1623 (20130101) Original (OR) Class B01D 2239/10 (20130101) B01D 2239/0618 (20130101) B01D 2273/18 (20130101) B01D 2279/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220347655 | Chao |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ecovia Renewables Inc. (Ann Arbor, Michigan) |
| ASSIGNEE(S) | Ecovia Renewables Inc. (Ann Arbor, Michigan) |
| INVENTOR(S) | Peng Chao (Ann Arbor, Michigan) |
| ABSTRACT | Disclosed are methods of preparing a cross-linked polymeric polycarboxylic acid by cross-linking the polymeric polycarboxylic acid with cross-linking agent comprising a polyepoxide and a polyhydrazide. Also disclosed are the cross-linked polymeric polycarboxylic acids made by the process and water-absorbent polymer materials comprising the cross-linked polymeric polycarboxylic acids. |
| FILED | Friday, October 02, 2020 |
| APPL NO | 17/765867 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/267 (20130101) Original (OR) Class B01J 20/3085 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 69/08 (20130101) C08G 69/48 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220347676 | Moon et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hyejin Moon (Austin, Texas); Shubhodeep Paul (Austin, Texas) |
| ABSTRACT | A method and system for performing biomolecule extraction are provided that use liquid-to-liquid extraction (LLE) in combination with an electrowetting on dielectric (EWOD) device to provide a biomolecule extraction solution that has high extraction efficiency and that is less costly and easier to use than current state of the art methods and systems. The system and method are well suited for, but not limited to, extraction of DNA, RNA and protein molecules. |
| FILED | Monday, June 27, 2022 |
| APPL NO | 17/850242 |
| CURRENT CPC | Separation B01D 11/0496 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) Original (OR) Class B01L 3/502784 (20130101) B01L 2400/0427 (20130101) Peptides C07K 1/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220347749 | Subramanian |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arunkumar Subramanian (Chicago, Illinois) |
| ABSTRACT | Atomic-to-Nanoscale Matter Emission/Flow Regulation Devices, Systems and methods are set forth. An exemplary device can include a through-hole that has a top, and a nozzle configured to facilitate atomic-to-nanoscale matter emission/flow regulation formed in an etchable nozzle substrate. The nozzle can be configured at the smallest cross-section of the through-hole. A bottom can be formed in the nozzle substrate or selectively connected to the nozzle. Systems can include matter transportation/flow regulation columns, printing systems, etching systems and the like through which self-aligned nanodroplets or single-to-finite numbered ionic species/gas phase matter can flow under spontaneous or external excitation conditions (such as voltages) at atmospheric as well as regulated pressures. |
| FILED | Monday, May 04, 2020 |
| APPL NO | 17/608020 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/20 (20210101) Original (OR) Class B22F 12/53 (20210101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/6708 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348501 | Rajabipour et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Farshad Rajabipour (State College, Pennsylvania); Gopakumar Kaladharan (State College, Pennsylvania); Tiffany Szeles (Keansburg, New Jersey); Shelley M. Stoffels (State College, Pennsylvania) |
| ABSTRACT | The present invention relates in part to an alkali-silica reaction mitigation admixture comprising an organic or inorganic salt that provides an aluminum, calcium, magnesium, or iron cation. The present invention also relates to a method of mitigating the alkali-silica reaction in a concrete product. The invention is further related to kits comprising the alkali-silica mitigation admixture and an instruction booklet. |
| FILED | Wednesday, September 09, 2020 |
| APPL NO | 17/641188 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 20/10 (20130101) C04B 22/06 (20130101) C04B 22/16 (20130101) C04B 22/085 (20130101) C04B 22/126 (20130101) C04B 22/128 (20130101) C04B 22/142 (20130101) C04B 24/04 (20130101) C04B 24/06 (20130101) C04B 24/10 (20130101) Original (OR) Class C04B 28/04 (20130101) C04B 40/0046 (20130101) C04B 2111/2023 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348854 | Luro et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott Luro (Cambridge, Massachusetts); Burak Okumus (Cambridge, Massachusetts); Johan Paulsson (Cambridge, Massachusetts) |
| ABSTRACT | A microfluidic device comprises a cell flow layer and a control layer. The cell flow layer includes a growth channel, a collection channel, a plurality of bridge channels connecting the growth channel and the collection channel, a plurality of bridge valve portions, and a plurality of cell growth trenches coupled to the growth channel. The growth channel includes an inlet valve portion and an outlet valve portion controlling flow into and out of the growth channel. The collection channel includes an inlet valve portion and an outlet valve controlling flow into and out of the collection channel. The bridge valve portions control flow between the growth channel and the collection channel. The control layer includes a first control channel actuating the bridge valve portions and a second control channel actuating the inlet valve portions and the outlet valve portions of the growth channel and the collection channel. |
| FILED | Monday, June 22, 2020 |
| APPL NO | 17/620636 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/16 (20130101) Original (OR) Class C12M 47/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348966 | AVALOS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey); Massachusetts Institute of Technology (Cambridge, Massachusetts); Whitehead Institute for Biomedical Research (Cambridge, Massachusetts); Kyoto University (Kyoto, Japan) |
| ASSIGNEE(S) | The Trustees of Princeton University (Princeton, New Jersey); Massachusetts Institute of Technology (Cambridge, Massachusetts); Whitehead Institute for Biomedical Research (Cambridge, Massachusetts); Kyoto University (Kyoto, Japan) |
| INVENTOR(S) | José L. AVALOS (Princeton, New Jersey); Sarah K. HAMMER (Philadelphia, Pennsylvania); Kouichi KURODA (Kyoto, Japan); Gerald R. FINK (Cambridge, Massachusetts); Gregory STEPHANOPOULOS (Winchester, Massachusetts) |
| ABSTRACT | A method for producing metabolites that are heavy alcohols, and particularly branched-chain alcohols is provided, involving contacting a suitable substrate with recombinant microorganisms. The microorganisms contain at least one deletion, disruptions, or mutations from the GLN gene family, VPS gene family, GNP gene family, AVT gene family, GCN gene family, or YDR391C, and combinations thereof, and overproduce the heavy alcohol as compared to a wild-type yeast strain. |
| FILED | Friday, September 25, 2020 |
| APPL NO | 17/763773 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/185 (20210501) C12N 15/81 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/04 (20130101) Original (OR) Class C12P 7/22 (20130101) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/865 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348972 | Pfleger et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin) |
| ASSIGNEE(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin) |
| INVENTOR(S) | Brian F Pfleger (Madison, Wisconsin); Nestor Hemandez-Lozada (Jena, Germany); Rung-Yi Lai (Changhua City, Taiwan) |
| ABSTRACT | Mutant thioesterases having enhanced medium chain substrate activity, polynucleotides encoding and configured to express the mutant thioesterases in a transformed host cell, host cells transformed to contain the polynucleotides, and methods of using same. |
| FILED | Tuesday, July 05, 2022 |
| APPL NO | 17/857624 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/16 (20130101) C12N 15/52 (20130101) C12N 15/70 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/6409 (20130101) Original (OR) Class Enzymes C12Y 301/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348990 | Kishi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Jocelyn Yoshiko Kishi (Cambridge, Massachusetts); Thomas E. Schaus (Cambridge, Massachusetts); Peng Yin (Cambridge, Massachusetts); Feng Xuan (Cambridge, Massachusetts); Nikhil Gopalkrishnan (Cambridge, Massachusetts); Sungwook Woo (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure provides, in some aspects, nucleic acid-based molecular tools that enable the recording of molecular structure and soluble signals as well as the programmed assembly of molecular structures. |
| FILED | Thursday, February 03, 2022 |
| APPL NO | 17/592435 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/64 (20130101) C12N 15/113 (20130101) C12N 2310/122 (20130101) C12N 2310/127 (20130101) C12N 2330/50 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6809 (20130101) C12Q 1/6811 (20130101) Original (OR) Class C12Q 1/6825 (20130101) C12Q 1/6853 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220349077 | Camacho Chico et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lucy Mar Camacho Chico (Corpus Christi, Texas); Mohammad U. Shafiq (Montgomery, Texas) |
| ASSIGNEE(S) | Texas A and M University System (College Station, Texas) |
| INVENTOR(S) | Lucy Mar Camacho Chico (Corpus Christi, Texas); Mohammad U. Shafiq (Montgomery, Texas) |
| ABSTRACT | Provided herein is an electrodialysis metathesis system that has at least one stack or quad of compartments arranged so each compartment is in fluid communication with its adjacent compartment via alternating cation—and anion-exchange membranes. The compartments in a stack are a feed compartment, a substitution salt solution compartment, a first concentrated compartment and a second concentrated compartment. Also provided are processes and methods for separating or recovering a metal, for example, a rare earth element, or a salt or a combination thereof from a salt-containing water. Simultaneous metathesis reactions and electrodialysis across the stack recovers one or more metal or salts from the salt-containing water which desalinates the salt-containing water. |
| FILED | Tuesday, July 19, 2022 |
| APPL NO | 17/868060 |
| CURRENT CPC | Processes for the Electrolytic Production, Recovery or Refining of Metals; Apparatus Therefor C25C 1/22 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220349373 | Son et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Steven Son (West Lafayette, Indiana); Kyle Uhlenhake (Lafayette, Indiana); Diane Collard (West Lafayette, Indiana); Mateo Gomez (West Lafayette, Indiana) |
| ABSTRACT | An igniter system and method for igniting a propellant by an optical energy source. The igniter system including an igniter composite and a propellant. The igniter composite including a reactive component and a fluoropolymer. The propellant is coupled to the igniter composite. The igniter composite has a composition including nano-aluminum at ideal stoichiometry in polyvinylidene fluoride. The igniter composite is configured to achieve a sustained ignition from a wavelength emitted from the optical energy source. The wavelength is between around 250 nanometers to around 1100 nanometers. |
| FILED | Monday, February 28, 2022 |
| APPL NO | 17/682026 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Jet-propulsion Plants F02K 9/95 (20130101) Ignition, Other Than Compression Ignition, for Internal-combustion Engines; Testing of Ignition Timing in Compression-ignition Engines F02P 23/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220349805 | JANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Myoseon JANG (Gainesville, Florida); Zechen YU (Gainesville, Florida) |
| ABSTRACT | A method is provided for detecting a composition of airborne particles. The method includes directing, with a pump, gas including particulate matter through a filter including an indicator dye. The method further includes causing a color change in the filter based on the particulate matter binding to the indicator dye. The method further includes transmitting, with an optical source, an optical signal at the filter. The method further includes detecting, with an imaging device, a reflected signal from the filter. The method further includes determining, with a processor, a value of a parameter of the particulate matter based on the color change, wherein the color change is based on the detected reflected signal. |
| FILED | Monday, October 26, 2020 |
| APPL NO | 17/778130 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/0618 (20130101) Original (OR) Class G01N 21/78 (20130101) G01N 21/85 (20130101) G01N 2015/0038 (20130101) Pictorial Communication, e.g Television H04N 13/189 (20180501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220349871 | Lee et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bongmook Lee (Raleigh, North Carolina); Veena Misra (Raleigh, North Carolina) |
| ABSTRACT | The present disclosure presents environmental sensing apparatuses and methods. In one such apparatus, an environmental sensor comprises a substrate and an array of multiple metal oxide materials on the substrate. The multiple metal oxide materials can comprise layers of different metal oxide material, in which the multiple metal oxide materials are deposited on a cross-bar array of heater elements and electrodes and each row in the cross-bar array contains an independently-controlled heater element and each column in the array contains a pair of electrodes. At each crossing of the heater element and the pair of electrodes, one of the multiple metal oxide materials is deposited, and the pair of electrodes and the heater elements are dielectrically isolated from one another at the crossing. |
| FILED | Friday, October 02, 2020 |
| APPL NO | 17/764332 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/497 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220350057 | Guler et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Urcan Guler (Avon, Connecticut); Alberto Naldoni (Torino, Italy); Alexander V. Kildishev (West Lafayette, Indiana); Alexandra Boltasseva (West Lafayette, Indiana); Vladimir M. Shalaev (West Lafayette, Indiana) |
| ABSTRACT | A nanostructured material system for efficient collection of photo-excited carriers is provided. They system comprises a plurality of plasmonic metal nitride core material elements coupled to a plurality of semiconductor material elements. The plasmonic nanostructured elements form ohmic junctions at the surface of the semiconductor material or at close proximity with the semiconductor material elements. A nanostructured material system for efficient collection of photo-excited carriers is also provided, comprising a plurality of plasmonic transparent conducting oxide core material elements coupled to a plurality of semiconductor material elements. The field enhancement, local temperature increase and energized hot carriers produced by nanostructures of these plasmonic material systems play enabling roles in various chemical processes. They induce, enhance, or mediate catalytic activities in the neighborhood when excited near the resonance frequencies. |
| FILED | Thursday, July 07, 2022 |
| APPL NO | 17/859665 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 27/24 (20130101) B01J 35/004 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 20/00 (20130101) Treatment of Inorganic Materials, Other Than Fibrous Fillers, to Enhance Their Pigmenting or Filling Properties; Preparation of Carbon Black; C09C 1/3607 (20130101) Optical Elements, Systems, or Apparatus G02B 5/008 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/5268 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220350137 | Chung et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Jae-Hyun Chung (Seattle, Washington); Vigneshwar Sakthivelpathi (Seattle, Washington); Sang-gyeun Ahn (Seattle, Washington) |
| ABSTRACT | An eye-tracking system, including at least one vertical capacitance sensor, configured to measure the vertical position of a cornea of a user's eye by sensing a position of an eyelid of the user; and at least one horizontal capacitance sensor, configured to measure the horizontal position of the cornea of the user's eye by sensing a position of the user's eyeball. |
| FILED | Friday, April 22, 2022 |
| APPL NO | 17/727644 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/113 (20130101) Optical Elements, Systems, or Apparatus G02B 27/0093 (20130101) Original (OR) Class G02B 27/0101 (20130101) G02B 2027/0132 (20130101) G02B 2027/0187 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220350221 | Moses et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey Moses (Ithaca, New York); Noah FLEMENS (Ithaca, New York); Nicolas SWENSON (Ithaca, New York) |
| ABSTRACT | In one aspect, a device is disclosed that includes one or more input ports structured to receive a pumping light at a pumping wavelength and a signal light at a signal wavelength, and one or more output ports structured to output light including an amplified signal light at the signal wavelength and a second harmonic idler light. The device includes a nonlinear optical material to mix the pumping light and the signal light and to cause nonlinear conversion of the pumping light into the amplified signal light and generate an idler light at an idler wavelength. The nonlinear optical material is further structured to convert the idler light into the second harmonic idler light which eliminates the idler light at the one or more output ports and prevents back-conversion of the amplified signal light and idler light to the pumping wavelength. |
| FILED | Monday, October 05, 2020 |
| APPL NO | 17/754475 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/392 (20210101) Original (OR) Class G02F 1/395 (20130101) G02F 1/3548 (20210101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/0092 (20130101) H01S 3/1083 (20130101) H01S 3/1312 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220352572 | Sloop |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HULICO LLC (Bend, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven E. Sloop (Bend, Oregon) |
| ABSTRACT | Examples are disclosed of methods to recycle positive-electrode material of a lithium-ion battery. One example provides a method including relithiating the positive-electrode material in a solution comprising lithium ions and an oxidizing agent, and after relithiating, separating the positive-electrode material from the solution. |
| FILED | Monday, July 18, 2022 |
| APPL NO | 17/867472 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/54 (20130101) Original (OR) Class H01M 10/0525 (20130101) H01M 2004/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20220347654 | GRAY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Department of Energy (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | MCMAHAN L. GRAY (Pittsburgh, Pennsylvania); FAN SHI (Pittsburgh, Pennsylvania); SHOULIANG YI (Pittsburgh, Pennsylvania); WALTER CHRIS WILFONG (Clinton, Pennsylvania); QIUMING WANG (Bridgeville, Pennsylvania) |
| ABSTRACT | One or more embodiments relates to method for generating CHEFS having the steps of generating the CHEFS from a dope. One or more embodiments relates to a method for generating CHEFS having amine functional groups having the steps of generating a dope containing a BIAS with amine groups, at least one polymer, and at least one solvent; and forming CHEFS from the dope, wherein the generated CHEFS have no more than 30% amine loss compared to the BIAS. |
| FILED | Friday, April 30, 2021 |
| APPL NO | 17/245092 |
| CURRENT CPC | Separation B01D 53/62 (20130101) B01D 53/81 (20130101) B01D 2253/202 (20130101) B01D 2257/504 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/103 (20130101) B01J 20/262 (20130101) Original (OR) Class B01J 20/3085 (20130101) B01J 20/28023 (20130101) B01J 2220/46 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348185 | Le et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cummins Inc. (Columbus, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dat Duc Le (Columbus, Indiana); Carlos A. Lana (Columbus, Indiana); Kenneth M. Follen (Greenwood, Indiana) |
| ABSTRACT | A system and method for power management of hybrid electric vehicles is provided. In some implementations, a plug-in series hybrid electric vehicle may include an engine, a motor/generator (MG), a traction motor, an energy storage device, and a controller. The controller is coupled to the engine and the MG to control operation of the engine and the MG such that a state-of-charge (SOC) of the energy storage device tracks a dynamic reference SOC profile during a trip and an average engine power (AEP) is maintained above a threshold. In some instances, maintaining AEP above a threshold supports emission control of the vehicle. |
| FILED | Sunday, May 02, 2021 |
| APPL NO | 17/246678 |
| CURRENT CPC | Arrangement or Mounting of Propulsion Units or of Transmissions in Vehicles; Arrangement or Mounting of Plural Diverse Prime-movers in Vehicles; Auxiliary Drives for Vehicles; Instrumentation or Dashboards for Vehicles; Arrangements in Connection With Cooling, Air Intake, Gas Exhaust or Fuel Supply of Propulsion Units in Vehicles B60K 6/24 (20130101) B60K 6/26 (20130101) B60K 6/28 (20130101) B60K 6/46 (20130101) Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 10/06 (20130101) B60W 10/08 (20130101) B60W 20/13 (20160101) Original (OR) Class B60W 2510/068 (20130101) B60W 2510/244 (20130101) B60W 2510/0619 (20130101) B60W 2510/0666 (20130101) B60W 2510/0676 (20130101) B60W 2520/10 (20130101) B60W 2530/209 (20200201) B60W 2540/10 (20130101) B60W 2555/20 (20200201) B60W 2710/06 (20130101) B60W 2710/08 (20130101) Indexing Scheme Relating to Aspects Cross-cutting Vehicle Technology B60Y 2200/92 (20130101) B60Y 2300/91 (20130101) Time or Attendance Registers; Registering or Indicating the Working of Machines; Generating Random Numbers; Voting or Lottery Apparatus; Arrangements, Systems or Apparatus for Checking Not Provided for Elsewhere G07C 5/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348680 | Pasqualini et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Renata Pasqualini (New Brunswick, New Jersey); Wadih Arap (New Brunswick, New Jersey); Fernanda Iamassaki Staquicini (New Brunswick, New Jersey); Fortunato Ferrara (Santa Fe, New Mexico); Sara D'Angelo (Santa Fe, New Mexico); Andrew R.M. Bradbury (Santa Fe, New Mexico) |
| ABSTRACT | Isolated or recombinant EphA5 or GRP78 targeting antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer. A method of rapidly identifying antibodies or antibody fragments for the treatment of cancer using a combination of in vitro and in vivo methodologies is also provided. |
| FILED | Friday, June 10, 2022 |
| APPL NO | 17/837888 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/07 (20130101) A61K 39/3955 (20130101) A61K 39/39558 (20130101) A61K 47/6803 (20170801) A61K 47/6817 (20170801) A61K 47/6843 (20170801) A61K 47/6849 (20170801) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/18 (20130101) C07K 16/28 (20130101) C07K 16/30 (20130101) Original (OR) Class C07K 16/2866 (20130101) C07K 16/3023 (20130101) C07K 2317/21 (20130101) C07K 2317/35 (20130101) C07K 2317/55 (20130101) C07K 2317/73 (20130101) C07K 2317/77 (20130101) C07K 2317/622 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1037 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57423 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348822 | Li et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jian Li (Tempe, Arizona); Xinqiang Tan (Tempe, Arizona) |
| ABSTRACT | A series of novel donor-acceptor type TADF luminogens have been designed with the aim of developing stable OLEDs with enhanced operational stability and improved color purity. These materials could be found utilization for full color displays and lighting applications. |
| FILED | Wednesday, December 23, 2020 |
| APPL NO | 17/132937 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) Original (OR) Class C09K 2211/1022 (20130101) C09K 2211/1066 (20130101) C09K 2211/1074 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0072 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348966 | AVALOS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey); Massachusetts Institute of Technology (Cambridge, Massachusetts); Whitehead Institute for Biomedical Research (Cambridge, Massachusetts); Kyoto University (Kyoto, Japan) |
| ASSIGNEE(S) | The Trustees of Princeton University (Princeton, New Jersey); Massachusetts Institute of Technology (Cambridge, Massachusetts); Whitehead Institute for Biomedical Research (Cambridge, Massachusetts); Kyoto University (Kyoto, Japan) |
| INVENTOR(S) | José L. AVALOS (Princeton, New Jersey); Sarah K. HAMMER (Philadelphia, Pennsylvania); Kouichi KURODA (Kyoto, Japan); Gerald R. FINK (Cambridge, Massachusetts); Gregory STEPHANOPOULOS (Winchester, Massachusetts) |
| ABSTRACT | A method for producing metabolites that are heavy alcohols, and particularly branched-chain alcohols is provided, involving contacting a suitable substrate with recombinant microorganisms. The microorganisms contain at least one deletion, disruptions, or mutations from the GLN gene family, VPS gene family, GNP gene family, AVT gene family, GCN gene family, or YDR391C, and combinations thereof, and overproduce the heavy alcohol as compared to a wild-type yeast strain. |
| FILED | Friday, September 25, 2020 |
| APPL NO | 17/763773 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/185 (20210501) C12N 15/81 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/04 (20130101) Original (OR) Class C12P 7/22 (20130101) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/865 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348970 | YOSHIKUNI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Yasuo YOSHIKUNI (Orinda, California); Justin B. SIEGEL (Davis, California); Youtian CUI (Davis, California); Wai Shun MAK (Sacramento, California) |
| ABSTRACT | Provided herein, inter alia, are methods, host cells, and vectors for producing 3-hydroxypropionate (3-HP). In some embodiments, the host cells include a recombinant polynucleotide encoding an oxaloacetate decarboxylase (OAADC) and a polynucleotide encoding a 3-hydroxypropionate dehydrogenase (3-HPDH). In some embodiments, the methods include culturing said host cell(s) in a culture medium comprising a substrate under conditions suitable for the recombinant host cell to convert the substrate to 3-HP. Expression of the OAADC and the 3-HPDH results in increased production of 3-HP, as compared to production by a host cell lacking expression of the OAADC and the 3-HPDH. |
| FILED | Monday, February 28, 2022 |
| APPL NO | 17/683101 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/16 (20130101) C12N 1/20 (20130101) C12N 9/0006 (20130101) C12N 9/88 (20130101) C12N 15/70 (20130101) C12N 2510/02 (20130101) C12N 2533/20 (20130101) C12N 2533/70 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/42 (20130101) Original (OR) Class Enzymes C12Y 101/01059 (20130101) C12Y 401/01003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220349493 | Agarwal et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vivek Agarwal (Idaho Falls, Idaho); Robert T. England (Ammon, Idaho); John W. Buttles (Idaho Falls, Idaho); Sasa Kovacevic (Pullman, Washington) |
| ABSTRACT | A device for measuring a state of a valve may include a housing configured to connect to a handle of a valve or a body of a valve, a sensor supported on one of the housing or the valve stem, and an indicator detectable by the sensor. The indicator may be configured to move relative to the sensor in response to movement of a valve stem or valve handle during opening and closing of the valve. The sensor may be configured to detect a position of the indicator to determine a state of the valve. Related systems and methods are also described. |
| FILED | Thursday, June 17, 2021 |
| APPL NO | 17/304314 |
| CURRENT CPC | Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 37/00 (20130101) Original (OR) Class F16K 37/0041 (20130101) F16K 37/0058 (20130101) F16K 37/0066 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220349572 | Choudhuri et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ahsan Choudhuri (El Paso, Texas); Mehrin Chowdhury (El Paso, Texas); Amzad Hossain (El Paso, Texas); Nawshad Arslan Islam (El Paso, Texas); Mohieminul Islam Khan (El Paso, Texas); Ana C. Rios (El Paso, Texas) |
| ABSTRACT | A swirl pintle coal slurry injector including a main body including at least one gas inlet; a pintle coupled to the main body, wherein the pintle comprises at least one coal slurry inlet and at least one slurry outlet, wherein the pintle defines a pintle axis; and a swirler coupled to the main body, wherein the swirler imparts to a gas from the at least one gas inlet of the main body a circular motion around the pintle axis, wherein the swirler surrounds the pintle axis and comprises a swirler number of approximately 1.2. The pintle can include a plurality of orifices of approximately 5 mm diameter. |
| FILED | Friday, April 29, 2022 |
| APPL NO | 17/661411 |
| CURRENT CPC | Burners F23D 1/02 (20130101) Original (OR) Class F23D 1/005 (20130101) F23D 2900/01001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220349650 | SIMPSON |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lin Jay SIMPSON (Lakewood, Colorado) |
| ABSTRACT | Provided herein are systems and methods for the processing of exhaust gases of industrial processes in order to reduce or eliminate emission of pollutants (including carbon dioxide) and store energy in the form of cryogenic liquids. Advantageously, the provided systems and methods utilize advanced heat exchanger systems to reduce or eliminate the net power required for operation. The heat exchangers are used both to reduce effluent gases to liquid temperatures as well as reheat previously cooled and separated gases, which can generate electricity via a turbo generator. The described systems and method may also produce cryogenic liquid products (Argon, Krypton, liquid Oxygen, liquid Nitrogen, etc.). |
| FILED | Monday, March 21, 2022 |
| APPL NO | 17/655613 |
| CURRENT CPC | Liquefaction, Solidification or Separation of Gases or Gaseous Mixtures by Pressure and Cold Treatment F25J 3/062 (20130101) F25J 3/067 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220349948 | KOWALSKI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Titan Advanced Energy Solutions, Inc. (Salem, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey A. KOWALSKI (Somerville, Massachusetts); Steven A. AFRICK (Boston, Massachusetts); Jay F. WHITACRE (Pittsburgh, Pennsylvania); Thomas C. FERREE (Waltham, Massachusetts); Maura APPLEBERRY (Somerville, Massachusetts); Shawn D. MURPHY (Salem, Massachusetts); Sean O'DAY (Boca Raton, Florida) |
| ABSTRACT | An energy storage device management system can include a management portion for charging/discharging an energy storage device and an ultrasound interrogation portion for passing ultrasound energy through the energy storage device during charge/discharge cycles. A memory stores a stream of capture data instances derived from ultrasound energy exiting the energy storage device and baseline ultrasound data instances corresponding with the energy storage device during normal charging/discharging thereof. A processor can compare each capture data instance with the baseline ultrasound data and detect abnormal operating states of the energy storage device. A warning system can issue a notification when abnormal operating states are detected. |
| FILED | Saturday, April 30, 2022 |
| APPL NO | 17/734005 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/367 (20190101) G01R 31/382 (20190101) G01R 31/396 (20190101) Original (OR) Class G01R 31/3646 (20190101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 7/0031 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220350039 | Jarrell et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livemore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joshua Jarrell (Livermore, California); Nerine Cherepy (Piedmont, California); John Winter Murphy (Mountain House, California); Rebecca J. Nikolic (Oakland, California); Erik Lars Swanberg, JR. (Livermore, California) |
| ABSTRACT | A product includes a transparent scintillator material, a beta emitter material having an end-point energy of greater than 225 kiloelectron volts (keV), and a photovoltaic portion configured to convert light emitted by the scintillator material to electricity. A thickness the scintillator material is sufficient to protect the photovoltaic portion from significant radiation damage. |
| FILED | Tuesday, July 12, 2022 |
| APPL NO | 17/863164 |
| CURRENT CPC | Measurement of Nuclear or X-radiation G01T 1/2002 (20130101) G01T 1/2023 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/115 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220351808 | Clyde et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Austin Robert Clyde (Chicago, Illinois); Arvind Ramanathan (Naperville, Illinois); Rick Stevens (Plainfield, Illinois) |
| ABSTRACT | A system can include one or more processors configured to identify a candidate molecule, provide the candidate molecule as an input to a simulation, operate the simulation, monitor at least one parameter of the simulation, modify the candidate molecule based on the at least one parameter, and output the modified candidate molecule responsive to a convergence condition being satisfied. |
| FILED | Thursday, April 29, 2021 |
| APPL NO | 17/244711 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/20 (20190201) G16B 15/30 (20190201) G16B 40/00 (20190201) Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 20/30 (20190201) Original (OR) Class G16C 20/70 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220351928 | Neubauer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Muons, Inc. (Batavia, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael L. Neubauer (San Francisco, California); Alan J. Dudas (Alamo, California); Stephen A. Kahn (Commack, New York) |
| ABSTRACT | An anode structure for a magnetron provides for low eddy currents and efficient water cooling. The anode structure may be made by machining a bimetal blank including an out layer of a first metal and an inner layer of a second metal and formed by explosion bonding. The second metal has a resistivity lower than first metal and a thermal conductivity higher than the first metal. The machining may result in the anode structure with vanes each having a center (tip) portion made of the second metal and the rest made of the first metal. The machined anode structure may be coated with the second metal. |
| FILED | Monday, July 11, 2022 |
| APPL NO | 17/862010 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 9/02 (20130101) H01J 23/02 (20130101) Original (OR) Class H01J 25/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220352498 | NARAYAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (LOS ANGELES, California) |
| ASSIGNEE(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (LOS ANGELES, California) |
| INVENTOR(S) | Sri R. NARAYAN (Arcadia, California); Aswin K. MANOHAR (Los Angeles, California); Chenguang YANG (Arcadia, California); G. K. Surya PRAKASH (Hacienda Heights, California); Robert ANISZFELD (Los Angeles, California) |
| ABSTRACT | A rechargeable battery includes an iron electrode comprising carbonyl iron composition dispersed over a fibrous electrically conductive substrate. The carbonyl iron composition includes carbonyl iron and at least one additive. A counter-electrode is spaced from the iron electrode. An electrolyte is in contact with the iron electrode and the counter-electrode such that during discharge. Iron in the iron electrode is oxidized with reduction occurring at the counter-electrode such that an electric potential develops. During charging, iron oxides and hydroxides in the iron electrode are reduced with oxidation occurring at the counter-electrode (i.e., a nickel electrode or an air electrode). |
| FILED | Friday, July 15, 2022 |
| APPL NO | 17/865447 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/26 (20130101) H01M 4/32 (20130101) H01M 4/043 (20130101) H01M 4/62 (20130101) H01M 4/248 (20130101) Original (OR) Class H01M 4/0471 (20130101) H01M 4/521 (20130101) H01M 10/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220352517 | Sakshaug et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Group14 Technologies, Inc. (Woodinville, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Avery Sakshaug (Snohomish, Washington); Henry R. Costantino (Woodinville, Washington); Aaron M. Feaver (Seattle, Washington); Leah A. Thompkins (Seattle, Washington); Katharine Geramita (Seattle, Washington); Benjamin E. Kron (Seattle, Washington); Sarah Fredrick (Denver, Colorado); Farshid Afkhami (Lake Stevens, Washington); Adam Strong (Lake Forest Park, Washington) |
| ABSTRACT | Composites of silicon and various porous scaffold materials, such as carbon material comprising micro-, meso- and/or macropores, and methods for manufacturing the same are provided. The compositions find utility in various applications, including electrical energy storage electrodes and devices comprising the same. |
| FILED | Thursday, July 07, 2022 |
| APPL NO | 17/860005 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/524 (20130101) C04B 38/0051 (20130101) C04B 38/0064 (20130101) C04B 41/009 (20130101) C04B 41/85 (20130101) C04B 41/5096 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/04 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/133 (20130101) H01M 4/134 (20130101) H01M 4/362 (20130101) H01M 4/364 (20130101) H01M 4/366 (20130101) H01M 4/386 (20130101) H01M 4/0416 (20130101) H01M 4/587 (20130101) Original (OR) Class H01M 4/625 (20130101) H01M 10/0525 (20130101) H01M 2004/021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220352534 | Treger |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CAMX Power LLC (Lexington, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jack Treger (Quincy, Massachusetts) |
| ABSTRACT | Provided are membranes useful for electrochemical or fuel cells. A membrane may be formed of or include a sulfonated polymer whereby the sulfonated polymer is covalently or ionically associated with a multi-nitrogen containing heterocyclic molecule. The resulting membranes possess excellent ion conductivity and selectivity. |
| FILED | Wednesday, July 06, 2022 |
| APPL NO | 17/858482 |
| CURRENT CPC | Separation B01D 67/0006 (20130101) B01D 67/0093 (20130101) B01D 69/10 (20130101) B01D 71/82 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/225 (20130101) C08J 5/2237 (20130101) C08J 2327/12 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/103 (20130101) Original (OR) Class H01M 8/188 (20130101) H01M 8/1011 (20130101) H01M 8/1062 (20130101) H01M 8/1081 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/50 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 70/50 (20151101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220352610 | Pozin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DURACELL U.S. OPERATIONS, INC. (Wilmington, Delaware); NATIONAL TECHNOLOGY and ENGINEERING SOLUTIONS OF SANDIA, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | DURACELL U.S. OPERATIONS, INC. (Wilmington, Delaware); NATIONAL TECHNOLOGY and ENGINEERING SOLUTIONS OF SANDIA, LLC (Albuquerque, New Mexico) |
| INVENTOR(S) | Michael Pozin (Brookfield, Connecticut); Walter Fred Paxton (Albuquerque, New Mexico); Bryan James Kaehr (Albuquerque, New Mexico) |
| ABSTRACT | A battery cell comprising a composite water-responsive safety layer and/or composite water- and pH-responsive safety layer to protect against tissue damage and/or electrolysis, when the battery cell is exposed to aqueous solution or tissue, is provided. The composite water-responsive safety layer and/or composite water- and pH-responsive safety layer is adapted to change from a non-electronically conducting state to an electronically conducting state. |
| FILED | Monday, July 18, 2022 |
| APPL NO | 17/866895 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0427 (20130101) H01M 50/10 (20210101) H01M 50/109 (20210101) H01M 50/116 (20210101) H01M 50/124 (20210101) H01M 50/531 (20210101) H01M 50/543 (20210101) H01M 50/572 (20210101) Original (OR) Class H01M 50/1245 (20210101) H01M 2200/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220352617 | Krueger |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| INVENTOR(S) | Daniel Scott Krueger (Kansas City, Missouri) |
| ABSTRACT | Waveguides and methods for manufacturing a waveguide that include forming a first channel in a first layer of dielectric material, the first channel comprising one or more walls; forming a second channel in a second layer of dielectric material, the second channel comprising one or more walls; depositing electrically conductive material on the one or more walls of the first channel; depositing electrically conductive material on the one or more walls of the second channel; arranging the first layer adjacent to the second layer to form a stack with the first channel axially aligned with and facing the second channel; and heating the stack so that the conductive material on the one or more walls of the first channel and the conductive material on the one or more walls of the second channel connect to form the waveguide. |
| FILED | Wednesday, July 13, 2022 |
| APPL NO | 17/863574 |
| CURRENT CPC | Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 3/16 (20130101) H01P 3/121 (20130101) H01P 11/002 (20130101) Original (OR) Class H01P 11/006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220352889 | Voss et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lars F. Voss (Livermore, California); Adam M. Conway (Livermore, California) |
| ABSTRACT | A high-voltage switch is adapted for use as a medium-voltage direct current circuit breaker, which provides a low-cost, small-footprint device to mitigate system faults. In one example, a method for operating a wideb and optical device includes illuminating the wide bandgap optical device with a light within a first range of wavelengths and a first average intensity, allowing a current to propagate therethrough without substantial absorption of the current, illuminating the wide bandgap optical device with light within the first range of wavelengths and a second average intensity that is lower than the first average intensity to allow a sustained current flow though the wide bandgap optical device, and illuminating the wide bandgap optical device with light within a second range of wavelengths to stop or substantially restrict propagation of the current through the wide gap material. |
| FILED | Tuesday, July 12, 2022 |
| APPL NO | 17/812018 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/09 (20130101) H01L 31/0288 (20130101) H01L 31/03042 (20130101) H01L 31/03044 (20130101) H01L 31/03125 (20130101) Pulse Technique H03K 17/78 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20220348359 | BACKUS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Spencer BACKUS (Pasadena, California); Gregory S. AGNES (Pasadena, California); Russell G. SMITH (Pasadena, California); Eric T. SUNADA (Pasadena, California); Blair J. EMANUEL (Pasadena, California); Rudranarayan M. MUKHERJEE (Pasadena, California); Samantha H. GLASSNER (Pasadena, California); Timothy P. SETTERFIELD (Pasadena, California) |
| ABSTRACT | Pointing interfaces that can be used to assemble/disassemble instruments/payloads from a spacecraft/host are disclosed. The disclosed interfaces provide structural, communications, power, and fluid connections (for thermal control). Such interfaces also provide active and passive vibration isolation capability for precision pointing. They can further act as an interface to the launch vehicle for secondary delivery of the instrument/payload to the spacecraft |
| FILED | Wednesday, April 27, 2022 |
| APPL NO | 17/731071 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/22 (20130101) Original (OR) Class B64G 2001/228 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348362 | Moses et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert W. Moses (Poguoson, Virginia); Foy M. Cheatwood (Norfolk, Virginia); Christopher O. Johnston (Yorktown, Virginia); Sergey Macheret (West Laafayette, Indiana); Bernard Parent (tucson, American Samoa); Justin Little (Seattle, Washington) |
| ABSTRACT | A magnetohydrodynamic (MHD) flow control mechanism is described which substantially improves the existing processes in that smaller magnetic fields, requiring far less mass, may be placed away from the forebody of the spacecraft to produce Lorentz forces that augment the lift and the drag forces for guidance, navigation, and control of the spacecraft. The MHD flow control mechanism may also be configured to provide additional thermal protection of the electrodes therein. |
| FILED | Friday, April 22, 2022 |
| APPL NO | 17/727401 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/62 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348909 | Hochrein et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lisa Hochrein (Pasadena, California); Mikhail H. Hanewich-Hollatz (Pasadena, California); Zhewei Chen (Pasadena, California); Heyun Li (Pasadena, California); Shashank Gandhi (Pasadena, California); Marianne Bronner (Pasadena, California); Niles A. Pierce (Pasadena, California) |
| ABSTRACT | Programmable guide RNAs (gRNAs) play a central role in the CRISPR revolution sweeping biology and medicine by directing the function of a Cas protein effector to a target gene of choice. To achieve programmable control over regulatory scope, the activity of a conditional guide RNA (cgRNA) depends on the presence or absence of an RNA trigger, allowing for cell-selective regulation of CRISPR/Cas function. Unlike a standard gRNA, a cgRNA is programmable at multiple levels, with the target-binding sequence controlling the target of Cas activity (edit, silence, induce, or bind a gene of choice) and the trigger binding sequence controlling the scope of Cas activity. cgRNA mechanisms that are allosteric allow for independent design of the target and trigger sequences, providing the flexibility to select the regulatory target and scope independently. Disclosed herein are allosteric cgRNA mechanisms for both ON→OFF logic (conditional inactivation by an RNA trigger) and OFF→ON logic (conditional activation by an RNA trigger). Allosteric cgRNAs enable restriction of CRISPR/Cas function to a desired cell type, tissue, organ, or disease state. Allosteric cgRNAs provide a versatile platform for cell-selective and tissue-selective research tools, biotechnologies, diagnostics, and therapeutics. |
| FILED | Tuesday, January 25, 2022 |
| APPL NO | 17/584237 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) Original (OR) Class C12N 2310/15 (20130101) C12N 2310/20 (20170501) C12N 2310/344 (20130101) C12N 2310/531 (20130101) C12N 2310/532 (20130101) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20220349351 — DESCENT OPERATION FOR AN AIRCRAFT PARALLEL HYBRID GAS TURBINE ENGINE PROPULSION SYSTEM
| US 20220349351 | Lents et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Raytheon Technologies Corporation (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles E. Lents (Amston, Connecticut); Joseph B. Staubach (Colchester, Connecticut); Larry W. Hardin (East Hartford, Connecticut); Jonathan Rheaume (West Hartford, Connecticut) |
| ABSTRACT | A gas turbine engine includes a core having a compressor section with a first compressor and a second compressor, a turbine section with a first turbine and a second turbine, and a primary flowpath fluidly connecting the compressor section and the turbine section. The first compressor is connected to the first turbine via a first shaft, the second compressor is connected to the second turbine via a second shaft, and a motor is connected to the first shaft such that rotational energy generated by the motor is translated to the first shaft. The gas turbine engine includes a takeoff mode of operation, a top of climb mode of operation, and at least one additional mode of operation. The gas turbine engine is undersized relative to a thrust requirement in at least one of the takeoff mode of operation and the top of climb mode of operation, and a controller is configured to control the mode of operation of the gas turbine engine. |
| FILED | Wednesday, June 15, 2022 |
| APPL NO | 17/840715 |
| CURRENT CPC | Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 27/10 (20130101) B64D 27/24 (20130101) B64D 31/06 (20130101) B64D 2027/026 (20130101) Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 15/10 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 6/14 (20130101) F02C 7/36 (20130101) Original (OR) Class F02C 9/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220349391 | Calkins et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Boeing Company (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Frederick T. Calkins (Renton, Washington); Douglas E. Nicholson (Saint Charles, Missouri); Jordan Kreitzman (Saint Charles, Missouri) |
| ABSTRACT | Variable-porosity panel systems and associated methods. A variable-porosity panel system includes a panel assembly with an exterior layer defining a plurality of exterior layer pores and a sliding layer adjacent to the exterior layer and defining a plurality of sliding layer pores. The variable-porosity panel system additionally includes a shape memory alloy (SMA) actuator configured to translate the sliding layer relative to the exterior layer to modulate a porosity of the panel assembly. The SMA actuator includes an SMA element configured to exert an actuation force on the sliding layer and at least partially received within an SMA element receiver of the sliding layer. The SMA element extends out of the sliding layer only at a sliding layer first end. A method of operating the variable-porosity panel system includes assembling the variable-porosity panel system and/or transitioning the panel assembly of the variable-porosity panel system among the plurality of panel configurations. |
| FILED | Thursday, February 24, 2022 |
| APPL NO | 17/679696 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 23/005 (20130101) Spring, Weight, Inertia or Like Motors; Mechanical-power Producing Devices or Mechanisms, Not Otherwise Provided for or Using Energy Sources Not Otherwise Provided for F03G 7/025 (20210801) F03G 7/0614 (20210801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220349880 | Li et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Kansas State University Research Foundation (Manhattan, Kansas); United States of America as Represented by the Administrator of NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jun Li (Manhattan, Kansas); Duy H. Hua (Manhattan, Kansas); Morgan James Anderson (Moffett Field, California); Jessica Erin Koehne (Moffett Field, California); Meyya Meyyappan (Moffett Field, California) |
| ABSTRACT | An electrochemical method for measuring the activity of biomarkers using microelectrode arrays functionalized with peptide consensus sequences and redox reporter moieties. Contact of the arrays with a biological sample containing one or more target biomarkers results in cleavage of the peptides and changes the electric current across the array in a quantifiable manner indicating not just the presence of the target biomarker in the sample, but its activity. |
| FILED | Tuesday, April 26, 2022 |
| APPL NO | 17/729494 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5438 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20220349201 | Barber |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Jeffrey B. Barber (Vineland, New Jersey) |
| ABSTRACT | A vertical escape structure comprises an escape housing disposed in a vertical orientation and mounted to a ground to maintain structural integrity in the vertical orientation against external flooding. The escape housing includes an interior which is sealed against water entry from exterior flooding and at least one of a staircase, a ladder, an elevator, or a lift disposed in the interior of the escape housing. The vertical escape structure further comprises a connecting walkway to connect the escape housing to a building. The escape housing has a smaller horizontal footprint than the building. The walkway is severable from the building by force without damaging the escape housing to cause water entry from the exterior flooding. |
| FILED | Wednesday, April 27, 2022 |
| APPL NO | 17/731084 |
| CURRENT CPC | Foundations; Excavations; Embankments; Underground or Underwater Structures E02D 27/12 (20130101) General Building Constructions; Walls, e.g Partitions; Roofs; Floors; Ceilings; Insulation or Other Protection of Buildings E04B 7/163 (20130101) Buildings or Like Structures for Particular Purposes; Swimming or Splash Baths or Pools; Masts; Fencing; Tents or Canopies, in General E04H 9/145 (20130101) Original (OR) Class E04H 12/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220350872 | McManus et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Kali McManus (Woodbridge, Virginia); Kristi Harmel (Colorado Springs, Colorado); Gregory Bennett (Colorado Springs, Colorado) |
| ABSTRACT | Examples are directed toward a system and method relating to mobile screening. For example, a mobile screening vehicle includes a passenger scanner that performs security scanning of a passenger on the mobile screening vehicle. The mobile screening vehicle also includes a verification system that verifies, consistent with the security scanning of passengers, that passengers on the mobile screening vehicle are approved to proceed to a secure area of a travel venue. |
| FILED | Thursday, April 28, 2022 |
| APPL NO | 17/731560 |
| CURRENT CPC | Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 40/08 (20130101) B60W 60/00253 (20200201) B60W 2540/043 (20200201) Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/3438 (20130101) G01C 21/3484 (20130101) G01C 21/3617 (20130101) Electric Digital Data Processing G06F 21/32 (20130101) Original (OR) Class G06F 21/44 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/06315 (20130101) G06Q 50/30 (20130101) Image or Video Recognition or Understanding G06V 40/40 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220353676 | Boyd et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Daniel A. Boyd (Arlington, Virginia); Kelli L. Biegger (McLean, Virginia); Chang Ellison (Arlington, Virginia); Brandon P. Gutierrez (Burke, Virginia); Jason Lim (Alexandria, Virginia); William Washington (North Potomac, Maryland) |
| ABSTRACT | A stopped vehicle information remote retrieval method includes an emergency personnel or first responder vehicle (FRV) establishing a vehicle connection between an infotainment system of a stopped vehicle and the FRV. The FRV sends a vehicle information request to the infotainment system of the stopped vehicle, via the vehicle connection, seeking release of vehicle information. The FRV obtains authentication of the vehicle information received in response to the vehicle information request. The FRV determines occupant status based on the vehicle information. The FRV communicates the passenger status to a first responder. |
| FILED | Wednesday, June 29, 2022 |
| APPL NO | 17/852687 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 7/10 (20130101) Wireless Communication Networks H04W 4/46 (20180201) H04W 12/02 (20130101) H04W 12/04 (20130101) Original (OR) Class H04W 12/08 (20130101) H04W 12/033 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20220346352 | Kraayenbrink et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elizabeth Ann Kraayenbrink (Ames, Iowa); Anna Butters-Johnson (Ames, Iowa); Derek Kraayenbrink (Ames, Iowa) |
| ABSTRACT | An apparatus, systems, and methods of providing enrichment to poultry during raising or maintaining of the poultry. One or more light sources project beams to generate laser spots at and around the poultry. A control regimen moves the light spots relative the poultry in generally random fashion during timed sessions for each given time period (e.g. each day). The spot movement is designed to promote benefits to poultry and producer in correlation to experimental data related to animal welfare, health, and commercial value. |
| FILED | Wednesday, June 29, 2022 |
| APPL NO | 17/809649 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 15/027 (20130101) Original (OR) Class A01K 39/01 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348888 | Estes et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Baylor College of Medicine (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mary K. Estes (Houston, Texas); David Graham (Houston, Texas); Robert Legare Atmar (Houston, Texas); Sue Ellen Crawford (Conroe, Texas); Khalil Ettayebi (Pearland, Texas); Kosuke Murakami (Houston, Texas) |
| ABSTRACT | Embodiments of the disclosure concern systems, methods, and/or compositions for cultivation of mammalian viruses, including at least human noroviruses and sapoviruses within the Caliciviridae family of viruses. The ex vivo culture systems include intestinal enteroids in combination with bile or a functionally active fraction or component thereof. In specific embodiments, the culture system is utilized to test inactivation compounds for therapeutic or environmental efficacy and to test contaminated comestibles and/or environmental entities for determination of the presence of infectious virus. Furthermore, antiviral compositions may be tested using systems of the disclosure, including drugs, small molecule inhibitors, and biologics such as neutralizing monoclonal antibodies. |
| FILED | Friday, July 08, 2022 |
| APPL NO | 17/811479 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/575 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0018 (20130101) C12N 5/0679 (20130101) C12N 7/00 (20130101) C12N 7/02 (20130101) Original (OR) Class C12N 2770/16051 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/569 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20220346721 | Johnson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin Johnson (Cincinnati, Ohio); Gregory O. Voss (Apple Valley, Minnesota); Colin G. Kenow (Saint Paul, Minnesota) |
| ABSTRACT | An apparatus having a longitudinal axis and an upper surface for supporting an individual at least partially positioned on a bed or other support structure, such as, for example, a bed within a magnetic resonance imaging (MRI) machine, is disclosed. The individual can have hips, legs and an upper back. The apparatus comprises a bladder that is configured to be positioned beneath the hips of the individual. The bladder has a first end and an opposed second end that is spaced from the first end along the longitudinal axis. The bladder is configured to expand upon receiving air from an air supply in order to elevate the hips of the individual relative to the upper back of the individual. A valve is in fluid communication with the bladder. The valve is configured to selectively allow air from the air supply into the bladder. The apparatus can be nonferrous. |
| FILED | Thursday, April 28, 2022 |
| APPL NO | 17/731839 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/702 (20130101) Original (OR) Class A61B 5/704 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220346981 | Major et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois); U.S. Govt. as rep by the Dept. of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Justin Major (Chicago, Illinois); Riley Marshall Knox (Mill Valley, California); Matthew Lawrence Elwin (Chicago, Illinois) |
| ABSTRACT | A limb activation system includes a sensor configured to monitor movement of a user. The system also includes a processor operatively coupled to the sensor and configured to determine, based on the movement of the user, that the user is engaged in walking or running. The processor is also configured to generate an activation signal responsive to the determination that the user is engaged in walking or running. A data-based model integrates sensor information to drive activation and arm swing of the affected upper limb. |
| FILED | Monday, March 28, 2022 |
| APPL NO | 17/705665 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/70 (20130101) Original (OR) Class A61F 2002/701 (20130101) A61F 2002/704 (20130101) A61F 2002/764 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/30 (20180101) G16H 40/63 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20220347468 | GARCIA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Kytopen Corporation (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paulo Andres GARCIA (Somerville, Massachusetts); Cullen BUIE (Cambridge, Massachusetts); Ross BEIGHLEY (Cambridge, Massachusetts); Rameech MCCORMACK (Cambridge, Massachusetts); James HEMPHILL (Medford, Massachusetts); Jessica SIDO (Alton, Illinois); Bethany GRANT (Scituate, Massachusetts) |
| ABSTRACT | Methods, devices, systems, and kits for electro-mechanical cell transfection are provided. A device includes a first electrode, a second electrode, and an active zone therebetween where an electrical potential difference applied to the first and second electrodes generates an electric field in the active zone sufficient to transfect at least a subset of the cells flowing in the active zone. |
| FILED | Wednesday, April 27, 2022 |
| APPL NO | 17/731112 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/327 (20130101) Original (OR) Class Apparatus for Enzymology or Microbiology; C12M 1/42 (20130101) C12M 35/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 13/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220348696 | Hancock et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Akita Innovations LLC (Billerica, Massachusetts) |
| ASSIGNEE(S) | Akita Innovations LLC (Billerica, Massachusetts) |
| INVENTOR(S) | Lawrence F. Hancock (North Andover, Massachusetts); Richard A. Minns (Arlington, Massachusetts) |
| ABSTRACT | Articles and methods related to the manufacture of polymers containing labile crosslinking moieties are generally described. |
| FILED | Wednesday, April 20, 2022 |
| APPL NO | 17/725280 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 8/50 (20130101) Original (OR) Class C08F 130/08 (20130101) C08F 228/02 (20130101) C08F 230/08 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 77/38 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20220349628 | Kotsubo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | National Institute of Standards and Technology (NIST) (Gaithersburg, Maryland) |
| INVENTOR(S) | Vincent Kotsubo (Superior, Colorado); Joel Ullom (Boulder, Colorado); Sae Woo Nam (Boulder, Colorado) |
| ABSTRACT | A compact, low power cryo-cooler for cryogenic systems capable of cooling gas to at least as low as 2.5 K. The cryo-cooler has a room temperature compressor followed by filtration. Within the cryostat, four counterflow heat exchangers precool the incoming high-pressure gas using the outflowing low-pressure gas. The three warmest heat exchangers are successively heat sunk to three stages of a pulse tube to absorb residual heat from the slight ineffectiveness of the heat exchangers. The pulse tube cold head also absorbs loads from instrumentation leads and radiation loads. The pulse tube stages operate at around 80 K, 25 K, and 10 K. The entire system—cryo-cooler, drive and control electronics, and detector instrumentation, fits in a standard electronics rack mount enclosure, and requires around 300 W or less of power. |
| FILED | Tuesday, July 05, 2022 |
| APPL NO | 17/857778 |
| CURRENT CPC | Refrigeration Machines, Plants or Systems; Combined Heating and Refrigeration Systems; Heat-pump Systems F25B 9/02 (20130101) Original (OR) Class F25B 9/10 (20130101) F25B 9/145 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20220351534 | MILLER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Derek H. MILLER (Alexandria, Virginia); Thomas J. GRAHAM (Chantilly, Virginia) |
| ABSTRACT | Provided herein are processing systems, computer readable media, and methods for processing undeliverable delivery items. A system includes a camera and a hardware processor operably connected to the camera and configured to perform operations that include capturing, using the camera, an image of a delivery item that is undeliverable to an intended recipient or at an intended delivery location, the image including an address of the intended recipient. The operations also include embedding, by the hardware processor, processing data with the image to thereby generate an embedded image as a printable file, the embedded image including the image of the delivery item framed by a template area that includes a reason for the delivery item being undeliverable. The operations also include notifying a sender of the delivery item that the delivery item is undeliverable via a hard copy printout of the embedded image. |
| FILED | Wednesday, July 13, 2022 |
| APPL NO | 17/863812 |
| CURRENT CPC | Postal Sorting; Sorting Individual Articles, or Bulk Material Fit to be Sorted Piece-meal, e.g by Picking B07C 3/00 (20130101) Electric Digital Data Processing G06F 3/12 (20130101) Image or Video Recognition or Understanding G06V 10/40 (20220101) G06V 30/416 (20220101) Original (OR) Class Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 5/22 (20130101) Pictorial Communication, e.g Television H04N 5/232 (20130101) H04N 5/2253 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20220353114 | ROBINSON |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rampart Communications, Inc. (Annapolis, Maryland) |
| ASSIGNEE(S) | Rampart Communications, Inc. (Annapolis, Maryland) |
| INVENTOR(S) | Matthew Brandon ROBINSON (Crownsville, Maryland) |
| ABSTRACT | A system includes first and second sets of communication devices. A processor coupled to the first set of communication devices produces a first encoded vector and transmits the first encoded vector to the second set of communication devices via a communication channel that applies a channel transformation to the first encoded vector during transmission. A processor coupled to the second set of communication devices receives the transformed signal, detects an effective channel thereof, and identifies left and right singular vectors of the effective channel. A precoding matrix is selected from a codebook of unitary matrices based on a message, and a second encoded vector is produced based on a second known vector, the precoding matrix, a complex conjugate of the left singular vectors, and the right singular vectors. The second encoded vector is sent to the first set of communication devices for identification of the message. |
| FILED | Tuesday, June 21, 2022 |
| APPL NO | 17/845965 |
| CURRENT CPC | Transmission H04B 7/0413 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 25/0391 (20130101) Original (OR) Class H04L 27/2602 (20130101) Wireless Communication Networks H04W 12/03 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, November 03, 2022.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20221103.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page