FedInvent™ Patent Applications
Application Details for Thursday, November 17, 2022
This page was updated on Friday, November 18, 2022 at 06:51 PM GMT
Department of Health and Human Services (HHS)
| US 20220361764 | Sutin et al. |
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| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Jason Sutin (Cambridge, Massachusetts); Maria Angela Franceschini (Winchester, Massachusetts); David Boas (Winchester, Massachusetts) |
| ABSTRACT | A system and method for non-invasively estimating an absolute blood flow of a vascular region in a subject using optical data are provided. In some aspects, the method includes acquiring optical data from the vascular region using one or more optical sensors placed about the subject, and determining, using the optical data, an index of blood flow and a blood volume associated with the vascular region. The method also includes computing a blood inflow and a blood outflow using the index of blood flow and the blood volume, and estimating an absolute blood flow using the blood inflow and blood outflow. The method further includes generating a report indicative of the absolute blood flow of the vascular region. |
| FILED | Tuesday, June 21, 2022 |
| APPL NO | 17/844958 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/021 (20130101) A61B 5/029 (20130101) A61B 5/031 (20130101) Original (OR) Class A61B 5/0075 (20130101) A61B 5/0205 (20130101) A61B 5/0261 (20130101) A61B 5/318 (20210101) A61B 5/369 (20210101) A61B 5/6814 (20130101) A61B 5/7246 (20130101) A61B 5/7278 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220361780 | Erraguntla et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TEXAS A and M UNIVERSITY SYSTEM (College Station, Texas); BAYLOR COLLEGE OF MEDICINE (Houston, Texas) |
| ASSIGNEE(S) | THE TEXAS A and M UNIVERSITY SYSTEM (College Station, Texas); BAYLOR COLLEGE OF MEDICINE (Houston, Texas) |
| INVENTOR(S) | Madhav Erraguntla (College Station, Texas); Darpit K. Dave (College Station, Texas); Balakrishna Haridas (College Station, Texas); Daniel J. DeSalvo (Houston, Texas); Siripoom V. McKay (Houston, Texas); Mark Alan Lawley (College Station, Texas); Achu Geetha Byju (College Station, Texas) |
| ABSTRACT | A method for predicting a hypoglycemic event or a hyperglycemic event includes (a) collecting one or more data streams, wherein at least one of the one or more data streams includes a glucose (GL) data stream corresponding to a user, (b) determining one or more features based on the one or more collected data streams, wherein at least one of the one or more features is distinct from each of the one or more data streams, (c) generating a prediction of whether or not a hypoglycemic event or a hyperglycemic event will occur by a prediction model based on the one or more features determined at (b), and (d) issuing an alert to the user in response to the prediction generated at (c) including a prediction that a hypoglycemic event or a hyperglycemic event will occur. |
| FILED | Friday, October 16, 2020 |
| APPL NO | 17/769883 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/7275 (20130101) A61B 5/7282 (20130101) A61B 5/14532 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220361802 | Voitiuk et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kateryna Voitiuk (Santa Cruz, California); Jinghui Geng (Santa Cruz, California); Robert Currie (Santa Cruz, California); Mircea Teodorescu (Santa Cruz, California) |
| ABSTRACT | An electrophysiological monitoring system includes an electrophysiology amplifier chip configured to couple to a plurality of electrophysiological electrodes and to measure electrophysiological signals. The system also includes a computing device configured to receive and to process the electrophysiological signals. The system further includes an interface device coupled to the electrophysiological amplifier chip and the computing device, the interface device configured to convert communication signals between the computing device and the electrophysiology amplifier chip. |
| FILED | Friday, May 13, 2022 |
| APPL NO | 17/743842 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/384 (20210101) Original (OR) Class A61B 5/386 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220361803 | EVERITT et al. |
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| FUNDED BY |
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| APPLICANT(S) | TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire) |
| ASSIGNEE(S) | TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire) |
| INVENTOR(S) | Alicia EVERITT (West Lebanon, New Hampshire); Ryan HALTER (Lyme, New Hampshire) |
| ABSTRACT | Disclosed is a system for evaluating brain trauma via regional changes in tissue impedance. The present disclosure describes a system for non-invasive intracranial monitoring, comprising two or more affecting electrodes arranged between a conductive location of a cranium of a patient and a location on a scalp of the patient, two or more effected electrodes arranged between the conductive location of the cranium of the patient and the location on the scalp of the patient, and processing circuitry configured to apply an electrical stimulus between the two or more affecting electrodes, measure an electrical stimulus differential between the two or more effected electrodes, calculate, for the two or more effected electrodes, a value of an impedance metric, and identify, based on the calculated value of the impedance metric, a health condition of the patient. |
| FILED | Friday, October 23, 2020 |
| APPL NO | 17/771273 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/053 (20130101) A61B 5/4064 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362153 | Wu |
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| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mei Xiong Wu (Lexington, Massachusetts) |
| ABSTRACT | Compositions and methods comprising Pulmonary Surfactant (PS)-biomimetic nanoparticles are disclosed. Specifically, the disclosure is related to a composition comprising a nanoparticle with an average size of 200-400 nm, including a plurality of pulmonary surfactant biomimetic molecules, wherein the nanoparticle is negatively charged; and one or more cargo molecules that are enveloped by the nanoparticle, wherein the cargo molecule has a molecular weight up to 1200 Da. |
| FILED | Tuesday, October 06, 2020 |
| APPL NO | 17/767140 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1271 (20130101) Original (OR) Class A61K 39/39 (20130101) A61K 39/145 (20130101) A61K 2039/55555 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362159 | COLLIER et al. |
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| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joel COLLIER (Durham, North Carolina); Sean KELLY (Durham, North Carolina) |
| ABSTRACT | The present disclosure provides, in part, peptide self-assemblies that are made into tablet form and methods of making and using the same. In some embodiments, the disclosure provides methods and formulations for a tabletized form of a vaccine, particularly a vaccine comprising self-assembling peptide-polymer nanofibers, an excipient and an adjuvant. Methods of making and using the tablet formulation are also provided. |
| FILED | Monday, September 28, 2020 |
| APPL NO | 17/764406 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0056 (20130101) A61K 9/2018 (20130101) A61K 9/2095 (20130101) Original (OR) Class A61K 47/60 (20170801) A61K 47/6929 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362163 | Wang et al. |
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| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Wang (Durham, North Carolina); Kin Man Au (Carrboro, North Carolina) |
| ABSTRACT | The present invention provides methods and compositions comprising a particle comprising at least one first targeting agent which binds a first target on an NK cell surface, and at least one second targeting agent which binds a second target on a cancer cell surface, wherein the second targeting agent is different from the first targeting agent. |
| FILED | Thursday, October 15, 2020 |
| APPL NO | 17/769917 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/51 (20130101) Original (OR) Class A61K 31/704 (20130101) A61K 39/001104 (20180801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362177 | Kester et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| INVENTOR(S) | Mark Kester (Afton, Virginia); Tye Deering (Charlottesville, Virginia); Thomas P. Loughran, JR. (Charlottesville, Virginia); Todd E. Fox (Charlottesville, Virginia); Pedro Filipe Da Costa Pinheiro (Charlottesville, Virginia); David J. Feith (Palmyra, Virginia) |
| ABSTRACT | Provided are methods for treating diseases, disorders, and conditions associated with undesirable cellular proliferation in subjects in need thereof. In some embodiments, the methods include administering to a subject in need thereof a therapeutically effective amount of a composition comprising, consisting essentially of, or consisting of a chemotherapeutic agent and a short chain ceramide. Also provided are methods for increasing total ceramide levels in cells, for increasing long chain ceramide to a very long chain ceramide ratios in cells, methods for enhancing apoptosis of cells, for prognosing subjects with diseases, disorders, and conditions associated with undesirable cellular proliferation with respect to treatments, for increasing sensitivities of drug-resistant tumor and/or cancer cells to chemotherapeutics, and compositions that have one or more short chain ceramides and one or more chemotherapeutically active agents. |
| FILED | Friday, October 16, 2020 |
| APPL NO | 17/769907 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/53 (20130101) A61K 31/164 (20130101) Original (OR) Class A61K 31/444 (20130101) A61K 31/497 (20130101) A61K 31/553 (20130101) A61K 31/635 (20130101) A61K 31/704 (20130101) A61K 31/706 (20130101) A61K 38/164 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/92 (20130101) G01N 2405/08 (20130101) G01N 2800/22 (20130101) G01N 2800/56 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362217 | TANG et al. |
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| FUNDED BY |
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| APPLICANT(S) | FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (Tallahassee, Florida); The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland); THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | HENGLI TANG (TALLAHASSEE, Florida); EMILY M. LEE (TALLAHASSEE, Florida); WEI ZHENG (ROCKVILLE, Maryland); RUILI HUANG (ROCKVILLE, Maryland); MIAO XU (ROCKVILLE, Maryland); WENWEI HUANG (ROCKVILLE, Maryland); KHALIDA SHAMIM (ROCKVILLE, Maryland); GUOLI MING (PHILADELPHIA, Pennsylvania); HONGJUN SONG (PHILADELPHIA, Pennsylvania) |
| ABSTRACT | The present invention concerns the use of compounds and compositions for the treatment or prevention of Flavivirus infections, such as dengue virus infections and Zika virus infections. Aspects of the invention include methods for treating or preventing Flavivirus virus infection, such as dengue virus and Zika virus infection, by administering a compound or composition of the invention, to a subject in need thereof; methods for inhibiting Flavivirus infections, such as dengue virus and Zika virus infections, in a cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits useful for treating or preventing Flavivirus infections, such as dengue virus and Zika virus infections. |
| FILED | Tuesday, June 28, 2022 |
| APPL NO | 17/809339 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/165 (20130101) A61K 31/245 (20130101) A61K 31/336 (20130101) A61K 31/352 (20130101) A61K 31/422 (20130101) A61K 31/427 (20130101) A61K 31/433 (20130101) A61K 31/506 (20130101) A61K 31/517 (20130101) A61K 31/519 (20130101) A61K 31/554 (20130101) A61K 31/4162 (20130101) A61K 31/4184 (20130101) Original (OR) Class A61K 31/4535 (20130101) A61K 31/4709 (20130101) A61K 31/4741 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362219 | Chen |
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| FUNDED BY |
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| APPLICANT(S) | Baylor College of Medicine (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rui Chen (Houston, Texas) |
| ABSTRACT | Embodiments of the disclosure encompass methods and compositions for the treatment of medical conditions in which cell regeneration is in need, including neural cells. In specific embodiments, the cell are retinal cells and include Müller glial cells. In particular embodiments, an individual with retinal regeneration is provided an effective amount of one or more histone acetylase inhibitors for the purpose of regenerating retinal cells, including retinal neurons. |
| FILED | Friday, December 11, 2020 |
| APPL NO | 17/757058 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/12 (20130101) A61K 31/60 (20130101) A61K 31/122 (20130101) A61K 31/365 (20130101) A61K 31/423 (20130101) Original (OR) Class A61K 31/426 (20130101) A61K 31/437 (20130101) A61K 31/515 (20130101) A61K 31/519 (20130101) A61K 31/4155 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362228 | KAHN et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Brigham And Women's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | The Brigham And Women's Hospital, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Josephine KAHN (Boston, Massachusetts); Siddhartha JAISWAL (Boston, Massachusetts); Benjamin EBERT (Boston, Massachusetts) |
| ABSTRACT | The present invention features methods for increasing sensitivity and/or reversing resistance to chemotherapy, methods for treating or preventing a cancer in a subject, methods for treating clonal hematopoiesis of indeterminate potential in a subject, and methods of identifying resistance or sensitivity to chemotherapy in a subject. In some embodiments, the methods contain the step of administering an agent that inhibits the expression or activity of a Protein phosphatase 1D (PPM1D) polypeptide or polynucleotide. The present invention also features compositions for increasing sensitivity and/or reversing resistance to chemotherapy. |
| FILED | Monday, March 07, 2022 |
| APPL NO | 17/688222 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/381 (20130101) A61K 31/675 (20130101) A61K 31/704 (20130101) A61K 31/4436 (20130101) Original (OR) Class A61K 31/7068 (20130101) A61K 33/243 (20190101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362236 | Trotti et al. |
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| FUNDED BY |
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| APPLICANT(S) | Thomas Jefferson University (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Davide Trotti (Bala Cynwyd, Pennsylvania); Piera Pasinelli (Bala Cynwyd, Pennsylvania); Michael R. Jablonski (Philadelphia, Pennsylvania) |
| ABSTRACT | The present invention provides a method of treating or ameliorating a neurodegenerative disease in a mammal, the method comprising administering to the mammal a therapeutically effective amount of a neurodegenerative disease drug, wherein the drug is a substrate of an ABC transporter inhibitor, wherein the mammal is further administered a therapeutically effective amount of an ARC transporter inhibitor, whereby the neurodegenerative disease is treated in the mammal. In certain embodiments, the neurode generative disease comprises at least one selected from the group consisting of spinal cord injury, Alzheimer's disease, Parkinson's disease, Huntington's disease, prion disease, amyotrophic lateral sclerosis, a tauopathy, and chronic traumatic encephalopathy. |
| FILED | Monday, May 23, 2022 |
| APPL NO | 17/750848 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/55 (20130101) A61K 31/428 (20130101) A61K 31/473 (20130101) Original (OR) Class A61K 31/496 (20130101) A61K 31/4725 (20130101) A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362254 | Mazo et al. |
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| FUNDED BY |
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| APPLICANT(S) | Thomas Jefferson University (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander Mazo (Cherry Hill, New Jersey); Bruno Calabretta (Philadelphia, Pennsylvania); Svetlana Petruk (Voorhees, New Jersey); Patrizia Porazzi (Philadelphia, Pennsylvania); David Deming (Philadelphia, Pennsylvania) |
| ABSTRACT | The present invention relates to methods and compositions for the treatment of cancer in a subject in need thereof by treatments that reprogram the cancer cells. |
| FILED | Friday, August 21, 2020 |
| APPL NO | 17/636997 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/42 (20130101) A61K 31/519 (20130101) A61K 31/573 (20130101) A61K 31/5377 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362297 | MORIARITY et al. |
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| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota); Intima Bioscience, Inc. (New York, New York); The U.S.A., as Represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Branden MORIARITY (Shoreview, Minnesota); Beau WEBBER (Coon Rapids, Minnesota); Modasir CHOUDHRY (New York, New York); Steven A. ROSENBERG (Potomac, Maryland); Douglas C. PALMER (North Bethesda, Maryland); Nicholas P. RESTIFO (Chevy Chase, Maryland) |
| ABSTRACT | Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer. |
| FILED | Thursday, February 17, 2022 |
| APPL NO | 17/674378 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class Peptides C07K 14/4718 (20130101) C07K 14/7051 (20130101) C07K 14/7158 (20130101) C07K 14/70503 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 9/22 (20130101) C12N 9/96 (20130101) C12N 15/87 (20130101) C12N 15/113 (20130101) C12N 15/907 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362310 | O'Toole et al. |
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| FUNDED BY |
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| APPLICANT(S) | Trustees of Dartmouth College (Hanover, New Hampshire); Dartmouth-Hitchcock Clinic (Lebanon, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George A. O'Toole (Hanover, New Hampshire); Juliette C. Madan (Lyme, New Hampshire) |
| ABSTRACT | The present disclosure relates to a method of altering intestinal microbiome in a patient having cystic fibrosis comprising administering at least one of Bifidobacterium and/or Bacteroides to a patient and allowing the Bifidobacterium and/or Bacteroides to alter the intestinal microbiome. |
| FILED | Thursday, May 19, 2022 |
| APPL NO | 17/664156 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/741 (20130101) A61K 35/744 (20130101) A61K 35/745 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) A61P 11/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362317 | SARKAR et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Saumendra N. SARKAR (Wexford, Pennsylvania); Stephen Howard THORNE (Pittsburgh, Pennsylvania) |
| ABSTRACT | The present disclosure provides oncolytic viruses expressing a modulator of interferon regulatory factors (IRFs), and compositions comprising thereof. The present disclosure further provides methods of using said oncolytic viruses and compositions for treating cancer, and for improving a subject's responsiveness to an immunomodulatory agent (e.g., an immune checkpoint inhibitor). |
| FILED | Thursday, July 21, 2022 |
| APPL NO | 17/869943 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/768 (20130101) Original (OR) Class A61K 39/3955 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/4702 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2710/24132 (20130101) C12N 2710/24143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362330 | Cherpes et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas Cherpes (Stanford, California); Rodolfo Vicetti Miguel (Stanford, California); Nirk Quispe Calla (Stanford, California) |
| ABSTRACT | Provided herein, inter alia, are compositions for the modulation of epithelium function, the compositions comprising EphrinA3 protein or EphrinA2 protein, fusions thereof, fragments thereof, or oligonucleotides encoding the same. Also provided are methods for modulating epithelium function, the methods comprising administration of compositions provided herein, including embodiments thereof. |
| FILED | Wednesday, October 07, 2020 |
| APPL NO | 17/767170 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/565 (20130101) A61K 31/7088 (20130101) A61K 35/68 (20130101) A61K 35/74 (20130101) A61K 38/177 (20130101) Original (OR) Class A61K 39/001196 (20180801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362333 | MARTINEZ-HACKERT et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| ASSIGNEE(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| INVENTOR(S) | Erik MARTINEZ-HACKERT (Okemos, Michigan); Monique FLOER (Okemos, Michigan) |
| ABSTRACT | Pharmaceutical compositions comprising a selective TGF-β inhibitor, such as a TGFβRII-Fc, are provided herein to prevent, reverse, reduce the occurrence of and/or treat fatty degeneration of skeletal muscle. Additionally, the selective TGF-β inhibitors may be used to inhibit fibro-adipogenic progenitor cell (FAP) differentiation into adipocytes. |
| FILED | Wednesday, July 22, 2020 |
| APPL NO | 17/628495 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/179 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362334 | MATALON et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE UAB RESEARCH FOUNDATION (Birmingham, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sadis MATALON (Birmingham, Alabama); Saurabh AGGARWALL (Birmingham, Alabama); Tamas JILLING (Birmingham, Alabama); Rakesh PATEL (Birmingham, Alabama) |
| ABSTRACT | Hemopexin, salubrinal, aurothioglucose, and nitrite find uses in treating pulmonary injury from several causes, alone and in combination. Methods of treatment, methods of prevention, and pharmaceutical compositions are provided with those components. |
| FILED | Friday, September 04, 2020 |
| APPL NO | 17/640534 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7135 (20130101) A61K 33/00 (20130101) A61K 38/1709 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362335 | Opal et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Puneet Opal (Evanston, Illinois); Chandrakanth Reddy Edamakanti (Evanston, Illinois) |
| ABSTRACT | Disclosed are compounds, compositions, and methods for treating and/or preventing neurodegenerative diseases and disorders. Particularly disclosed are compounds, compositions, and methods for treating and/or preventing neurodegenerative diseases and disorders such as spinocerebellar ataxia type 1 (SCA1) by administering a JNK inhibitor. |
| FILED | Thursday, May 12, 2022 |
| APPL NO | 17/663028 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362340 | Greenberger et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania); WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joel Greenberger (Sewickley, Pennsylvania); Michael Epperly (Pittsburgh, Pennsylvania); Xichen Zhang (Cheswick, Pennsylvania); Jan Peter Van Pijkeren (Madison, Wisconsin) |
| ABSTRACT | Disclosed herein are gastrointestinal tract (G1) bacteria and methods for treating or preventing an irradiation-induced intestinal damage in a subject, the methods comprising administering a G1 bacterium to the subject, wherein the G1 bacterium comprises a vector that comprises a polynucleotide encoding IL-22 and/or IFN-P, or a functional fragment thereof. |
| FILED | Friday, October 30, 2020 |
| APPL NO | 17/773373 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/341 (20130101) A61K 31/352 (20130101) A61K 31/4178 (20130101) A61K 31/4184 (20130101) A61K 31/4468 (20130101) A61K 35/741 (20130101) A61K 35/747 (20130101) A61K 38/20 (20130101) Original (OR) Class A61K 38/193 (20130101) A61K 38/215 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362358 | Fischbach et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Chan Zuckerberg Biohub, Inc. (San Francisco, California); The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael A. Fischbach (Redwood City, California); Kazuki Nagashima (Palo Alto, California); Yiyin E. Chen (Stanford, California) |
| ABSTRACT | Provided are modified microorganisms, such as live recombinant commensal bacteria, that express a heterologous antigen, and methods of using the modified microorganisms to induce an antigen-specific immune response to the heterologous antigen. The modified microorganism can be used to induce a regulatory T cell immune response to the heterologous antigen to treat an autoimmune disease in a subject in need thereof, or can be used to induce an effector T cell immune response to the heterologous antigen to treat a proliferative disease in a subject in need thereof. |
| FILED | Thursday, June 18, 2020 |
| APPL NO | 17/620633 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0008 (20130101) Original (OR) Class A61K 39/001156 (20180801) A61K 39/001186 (20180801) A61K 39/001188 (20180801) A61K 39/001191 (20180801) A61K 39/001198 (20180801) A61K 2039/54 (20130101) A61K 2039/523 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/06 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 5/0636 (20130101) C12N 15/62 (20130101) C12N 15/74 (20130101) C12N 2502/99 (20130101) C12N 2502/1121 (20130101) C12N 2800/101 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362374 | MATYAS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States, as represented by the Secretary of the Army (Fort Detrick, Maryland); The United States of America, as represented by the Secretary, Department of Health (Bethesda, Maryland) |
| ASSIGNEE(S) | The Government of the United States, as represented by the Secretary of the Army (Fort Detrick, Maryland); The United States of America, as represented by the Secretary, Department of Health (Bethesda, Maryland) |
| INVENTOR(S) | Gary R. MATYAS (Olney, Maryland); Rodell C. BARRIENTOS (Rockville, Maryland); Oscar B. TORRES (Rockville, Maryland); Connor WHALEN (Cranberry Township, Pennsylvania); Therese OERTEL (Silver Spring, Maryland); Kenner C. RICE (Bethesda, Maryland); Arthur E. JACOBSON (Rockville, Maryland); Eric W. BOW (Washington, District of Columbia); Agnieszka SULIMA (Poolesville, Maryland) |
| ABSTRACT | The present disclosure is directed to isolated recombinant antibodies, or antigen-binding fragments thereof, that bind to fentanyl or fentanyl analogs. The novel antibodies or antigen-binding fragments thereof can be used to detect, diagnose, treat, and/or prevent opioid use disorder. |
| FILED | Thursday, April 28, 2022 |
| APPL NO | 17/661160 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0013 (20130101) A61K 39/385 (20130101) Original (OR) Class A61K 47/646 (20170801) A61K 47/6415 (20170801) A61K 2039/505 (20130101) A61K 2039/6012 (20130101) A61K 2039/6037 (20130101) A61K 2039/55505 (20130101) A61K 2039/55572 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/36 (20180101) Peptides C07K 16/44 (20130101) C07K 2317/24 (20130101) C07K 2317/76 (20130101) C07K 2317/565 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362375 | Chang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yung Chang (Tempe, Arizona); Sidney Hecht (Phoenix, Arizona); Joseph Leal (Phoenix, Arizona); Viswanath Arutla (Tempe, Arizona); Xiaowei Liu (Tempe, Arizona); Sriram Sokalingam (Tempe, Arizona) |
| ABSTRACT | Provided herein are methods for rational design of nicotine haptens. More particularly, provided herein are methods for designing, selecting, and synthesizing nicotine haptens and nicotine hapten conjugates. Also provided herein are novel nicotine haptens and methods for using nicotine haptens to treat nicotine addiction. |
| FILED | Thursday, May 12, 2022 |
| APPL NO | 17/743058 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0013 (20130101) A61K 39/385 (20130101) Original (OR) Class A61K 47/646 (20170801) A61K 2039/6012 (20130101) Heterocyclic Compounds C07D 401/14 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/946 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/00 (20190201) G16B 15/30 (20190201) G16B 20/00 (20190201) G16B 20/30 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362389 | MEDINA-KAUWE |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cedars-Sinai Medical Center (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lali K. MEDINA-KAUWE (Porter Ranch, California) |
| ABSTRACT | Disclosed herein are drug delivery molecules that comprise a ligand that targets a cell surface molecule; a membrane penetration domain; and a payload binding domain; and pharmaceutical compositions comprising the same. Also disclosed are methods of treating cancer, inhibiting the progression of cancer, preventing cancer metastasis, and delivering a therapeutic compound to the brain in a subject in need thereof, the methods comprising identifying a subject in need thereof; providing a composition comprising the drug delivery molecule as disclosed herein; and administering an effective amount of the composition to the subject. |
| FILED | Monday, May 23, 2022 |
| APPL NO | 17/751366 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/5169 (20130101) A61K 31/7105 (20130101) A61K 47/64 (20170801) Original (OR) Class A61K 47/6803 (20170801) A61K 47/6851 (20170801) A61K 47/6929 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362409 | Schaffer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David V. Schaffer (Danville, California); John G. Flannery (Berkeley, California); William A. Beltran (Philadelphia, Pennsylvania); Leah C. Byrne (San Francisco, California); Meike Visel (El Cerrito, California) |
| ABSTRACT | The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells compared to wild-type AAV. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease. |
| FILED | Thursday, June 16, 2022 |
| APPL NO | 17/842530 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 48/0075 (20130101) A61K 48/0091 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2750/14121 (20130101) C12N 2750/14122 (20130101) C12N 2750/14143 (20130101) C12N 2750/14145 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362579 | Robinson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Clifford G. Robinson (Chesterfield, Missouri); Phillip S. Cuculich (St. Louis, Missouri) |
| ABSTRACT | A noninvasive system for imaging, planning, and treating cardiac arrhythmia in a subject includes a noninvasive means for imaging a heart and identifying an arrhythmia including an array of body surface electrodes for noninvasively measuring electrical potentials at a plurality of locations to identify the arrhythmia, and a geometry determining device for noninvasively obtaining a heart-torso geometry. An imaging processor computes heart electrical activity data and generates an image of the heart from the electrical potentials and the heart-torso geometry. A treatment planning system for developing a noninvasive treatment plan for the arrhythmia is configured to import an arrhythmia target defined relative to the image of the heart, and register the imported arrhythmia target to a primary planning dataset. A noninvasive means for treating the arrhythmia includes implementing the noninvasive treatment plan developed by the treatment planning system. |
| FILED | Thursday, July 14, 2022 |
| APPL NO | 17/812594 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/032 (20130101) A61B 6/503 (20130101) A61B 6/5247 (20130101) A61B 8/5261 (20130101) A61B 18/00 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/10 (20130101) A61N 5/1039 (20130101) Original (OR) Class A61N 5/1068 (20130101) A61N 5/1083 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362765 | Folch et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Albert Folch (Seattle, Washington); Adan Rodriguez (Seattle, Washington); Lisa Horowitz (Seattle, Washington); Allan Sung King Au-Yeung (Seattle, Washington); Priscilla Delgado (Seattle, Washington) |
| ABSTRACT | Devices, systems, and methods for trapping and manipulating portions of tissue are described. In an embodiment, the devices include an array of traps, wherein traps of the array of traps are shaped to trap a tissue sample; and a well is in registry and fluidic communication with a trap of the array of traps. |
| FILED | Friday, September 18, 2020 |
| APPL NO | 17/761552 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) Original (OR) Class B01L 2400/0475 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362769 | Reiserer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ronald S. Reiserer (Nashville, Tennessee); David K. Schaffer (Nashville, Tennessee); Philip C. Samson (Nashville, Tennessee); Dmitry A. Markov (Nashville, Tennessee); Michael Geuy (Nashville, Tennessee); Lisa J. McCawley (Nashville, Tennessee); John P. Wikswo (Brentwood, Tennessee) |
| ABSTRACT | Microfluidic systems, pumps, valves and applications of the same are provided. The microfluidic system may be a pump or a valve having a fluidic chip and an actuator controlling the opening and closing of the fluidic channel in the fluidic chip. The actuator may be disposed to tilt from the fluidic chip, forming a tilted-rotor peristaltic pump. Alternatively, the actuator may be a rolling ball actuator, and different fluidic chips may be used in different applications. For example, the fluidic chip may be a spiral pump chip having spiral channels, a rotary peristaltic pump chip having multiple output channels, or a multi-port valve chip having one port interconnected with multiple different ports. An analytical valve chip may switchably interconnect bioreactor and rinse/calibration input channels to sensor and waste output channels. The actuator of a random-access valve can move from one valve position to another without opening or closing intermediate ones. |
| FILED | Monday, June 29, 2020 |
| APPL NO | 17/623350 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502738 (20130101) Original (OR) Class B01L 2300/123 (20130101) B01L 2300/0627 (20130101) B01L 2400/0644 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362772 | WANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tza-Huei Jeff WANG (Baltimore, Maryland); Christine M. O'KEEFE (Baltimore, Maryland); Aniruddha Mrithinjay KAUSHIK (Baltimore, Maryland) |
| ABSTRACT | Provided herein are microfluidic devices for analyzing samples. In one aspect, the microfluidic device includes a body structure having a droplet compression chamber, a sieve structure in fluid communication with the droplet compression chamber, which sieve structure comprises an array of protrusions that extend from at least one surface of the body structure and define at least a portion of one or more fluidic circuits, and a port at least partially disposed in the body structure. Other aspects include kits, methods, systems, computer readable media, and related aspects for analyzing samples. |
| FILED | Wednesday, July 01, 2020 |
| APPL NO | 17/624440 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) Original (OR) Class B01L 2200/0673 (20130101) B01L 2300/18 (20130101) B01L 2300/0654 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6858 (20130101) C12Q 2600/154 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220363639 | GRENIER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania); VAL-CHUM, LIMITED PARTNERSHIP (Quebec, Canada) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Melissa Carey GRENIER (Philadelphia, Pennsylvania); Amos B. SMITH, III (Merion, Pennsylvania); Andres FINZI (Quebec, Canada); Shilei DING (Quebec, Canada); Jean-Philippe CHAPLEAU (Quebec, Canada) |
| ABSTRACT | Compounds and methods of treating HIV-1 in a human infected with HIV-1 or preventing HIV-1 infection in a human susceptible to infection with HIV-1 are provided. The compounds are of formula (I), (II), and (IA), wherein R1-R7, X, X′, Y, Y′, Z, and n are defined herein, and the methods comprises administering therapeutically effective amounts of these compounds to the human. |
| FILED | Wednesday, July 31, 2019 |
| APPL NO | 17/263590 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Heterocyclic Compounds C07D 207/48 (20130101) C07D 211/56 (20130101) C07D 211/60 (20130101) C07D 211/96 (20130101) Original (OR) Class C07D 215/54 (20130101) C07D 241/04 (20130101) C07D 265/30 (20130101) C07D 309/08 (20130101) C07D 401/12 (20130101) C07D 403/12 (20130101) C07D 413/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220363672 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jun O. Liu (Clarksville, Maryland); Yingjun Li (Baltimore, Maryland); Kalyan Kumar Pasunooti (Singapore, Singapore); Wukun Liu (Baltimore, Maryland); Wei Shi (Fayetteville, Arkansas); Ruojing Li (Baltimore, Maryland); Sarah Head (Baltimore, Maryland) |
| ABSTRACT | Provided herein are Itraconazole analogs. Also provided herein are methods of inhibition of Hedgehog pathway, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, angiogenesis and treatment of disease with Itraconazole analogs. |
| FILED | Friday, April 30, 2021 |
| APPL NO | 17/245875 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/506 (20130101) Heterocyclic Compounds C07D 405/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220363688 | Ghosh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundarion (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arun K. Ghosh (West Lafayette, Indiana); Satish Kovela (West Lafayette, Indiana); Hiroaki Mitsuya (Kumamoto, Japan) |
| ABSTRACT | Various embodiments of the present invention are directed to compounds of the formula (I) or a pharmaceutically acceptable salt, polymorph, prodrug, solvate or clathrate thereof. The compounds disclosed herein are as inhibitors of HIV-1 protease and, as a result, are useful in the treatment of HIV infection. |
| FILED | Wednesday, January 15, 2020 |
| APPL NO | 17/423245 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Heterocyclic Compounds C07D 493/08 (20130101) Original (OR) Class Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/6561 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220363692 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland); Rapafusyn Pharmaceuticals, Inc. (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (, None); Rapafusyn Pharmaceuticals, Inc. (, None) |
| INVENTOR(S) | Jun Liu (Clarksville, Maryland); Sam Hong (Baltimore, Maryland); Brett R. Ullman (Baltimore, Maryland); Joseph E. Semple (Baltimore, Maryland); Kana Yamamoto (Baltimore, Maryland); Puneet Kumar (Baltimore, Maryland); Magesh Sadagopan (Baltimore, Maryland); Jennifer C. Schmitt (Baltimore, Maryland) |
| ABSTRACT | The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocyles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases. |
| FILED | Thursday, May 27, 2021 |
| APPL NO | 17/332331 |
| CURRENT CPC | Heterocyclic Compounds C07D 498/04 (20130101) C07D 498/14 (20130101) Original (OR) Class Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/3258 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220363712 | BOEKE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CDI LABORATORIES, INC. (Mayaquez, None); The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jef D. BOEKE (Baltimore, Maryland); Heng ZHU (Towson, Maryland); Seth BLACKSHAW (Baltimore, Maryland); Daniel J. EICHINGER (Pleasantville, New York); Ignacio PINO (Mayaquez, None) |
| ABSTRACT | Provided herein is a library of antibodies, wherein the library of antibodies can comprise a plurality of monoclonal, monospecific, or immunoprecipitating antibodies. Also provided herein is a method for producing and using the library of antibodies. |
| FILED | Monday, June 06, 2022 |
| APPL NO | 17/833001 |
| CURRENT CPC | Peptides C07K 1/047 (20130101) Original (OR) Class C07K 16/00 (20130101) C07K 2317/33 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6845 (20130101) G01N 33/6854 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220363722 | Pahan |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rush University Medical Center (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kalipada Pahan (Skokie, Illinois) |
| ABSTRACT | Compositions for inhibiting the binding between ACE2 and SARS-CoV-2 spike S1 are disclosed. Methods of treating COVID-19 are disclosed. Methods of making an in vivo model of COVID-19 are also disclosed. |
| FILED | Monday, March 21, 2022 |
| APPL NO | 17/699792 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/162 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/005 (20130101) Original (OR) Class C07K 2319/10 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2770/20022 (20130101) C12N 2770/20033 (20130101) C12N 2770/20071 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220363736 | PALESE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (New York, New York) |
| ASSIGNEE(S) | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (New York, New York) |
| INVENTOR(S) | Peter PALESE (New York, New York); Florian KRAMMER (New York, New York); Teddy John WOHLBOLD (New York, New York); Adolfo GARCIA-SASTRE (New York, New York) |
| ABSTRACT | Provided herein are antibodies that bind to neuraminidase (NA) of different strains of influenza B virus, host cells for producing such antibodies, and kits comprising such antibodies. Also provided herein are compositions comprising antibodies that bind to NA of different strains of influenza B virus and methods of using such antibodies to diagnose, prevent or treat influenza virus disease. |
| FILED | Wednesday, January 05, 2022 |
| APPL NO | 17/569253 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) Peptides C07K 16/1018 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220363737 | Miller et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey S. Miller (Minneapolis, Minnesota); Martin Felices (Minneapolis, Minnesota); Todd Lenvik (Minneapolis, Minnesota); Daniel A. Vallera (Minneapolis, Minnesota) |
| ABSTRACT | This disclosure describes compounds that engage NK cells and methods of using the compounds. Generally, the compound includes an NK engaging domain, a targeting domain that selectively binds to a target cell, and an NK activating domain operably linking the NK engaging domain and the targeting domain. In an illustrative embodiment, the targeting domain selectively binds to an HIV antigen. |
| FILED | Friday, September 25, 2020 |
| APPL NO | 17/762354 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Peptides C07K 14/5443 (20130101) C07K 16/283 (20130101) C07K 16/1045 (20130101) Original (OR) Class C07K 2317/22 (20130101) C07K 2317/569 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220363745 | Michelsen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CEDARS-SINAI MEDICAL CENTER (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kathrin S. Michelsen (Los Angeles, California); Stephan R. Targan (Santa Monica, California) |
| ABSTRACT | The present invention relates to the finding that TL1A enhances differentiation of TH17 cells, and enhance IL17 secretion from TH17 cells. In one embodiment, the present invention provides a method of treating an inflammatory disease comprising determining the presence of a TL1A signaling profile, and treating the disease by administering a composition comprising a therapeutically effective dosage of one or more inhibitors of TL1A or TH17 cell differentiation. In another embodiment, the disease is characterized by TH17 differentiation. |
| FILED | Tuesday, March 22, 2022 |
| APPL NO | 17/701372 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/3955 (20130101) A61K 45/06 (20130101) Peptides C07K 16/241 (20130101) Original (OR) Class C07K 16/244 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) C12Q 1/6883 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/50 (20130101) G01N 33/53 (20130101) G01N 33/68 (20130101) G01N 33/483 (20130101) G01N 33/6863 (20130101) G01N 33/56966 (20130101) G01N 2800/065 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220363766 | WUCHERPFENNIG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kai WUCHERPFENNIG (Brookline, Massachusetts); Lucas FERRARI DE ANDRADE (Alston, Massachusetts); Adrienne LUOMA (Boston, Massachusetts) |
| ABSTRACT | Embodiments described herein are directed to compositions and methods for treating tumors resistant to checkpoint blockade by activating NK cells. |
| FILED | Friday, October 09, 2020 |
| APPL NO | 17/767035 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4045 (20130101) A61K 35/17 (20130101) A61K 38/1774 (20130101) A61K 39/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2833 (20130101) Original (OR) Class C07K 2317/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1138 (20130101) C12N 2310/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220363905 | Choi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts); Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hak Soo Choi (Needham, Massachusetts); Jonghan Kim (Cambridge, Massachusetts); Georges El Fakhri (Brookline, Massachusetts) |
| ABSTRACT | Provided herein are compounds that are able to bind metal ions (e.g., free metal ions or metal ions bound to low affinity ligands) in a sample or subject. Also provided herein are methods of using the compounds for chelating metal ions and for the treatment of diseases associated with abnormal levels of metal ions. Methods of preparing the compounds and pharmaceutical compositions are also provided. |
| FILED | Friday, April 29, 2022 |
| APPL NO | 17/733766 |
| CURRENT CPC | Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 23/0025 (20130101) C09B 23/0033 (20130101) C09B 23/0041 (20130101) C09B 23/0066 (20130101) Original (OR) Class C09B 69/105 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220364047 | He et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaoming He (Bethesda, Maryland); Jiangsheng Xu (Greenbelt, Maryland); James Shamul (Lanham, Maryland) |
| ABSTRACT | Disclosed are microcapsule compositions and methods for encapsulating living cells. The methods include a microencapsulation approach to isolate and culture high-quality stem cells, including human iPSCs, cancer stem cells, cardiac stem cells, and the like. The microencapsulation methods are inspired by the development of blastomeres into a blastocyst within the Zona pellucida of the human female reproductive system. The bioinspired methods include encapsulation of blastomere-like cell clusters in a Zona-like microcapsule including a miniaturized hyaluronic acid-rich core and a semipermeable hydrogel shell. The cell clusters are subsequently cultured to form highly pluripotent spheroids with improved cell quality, homogeneity, and viability. Methods of use of said microcapsules are also disclosed including therapeutic uses related to human iPSC-based personalized medicines. |
| FILED | Friday, May 13, 2022 |
| APPL NO | 17/663372 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0012 (20130101) Original (OR) Class C12N 5/0657 (20130101) C12N 5/0695 (20130101) C12N 5/0696 (20130101) C12N 2506/45 (20130101) C12N 2533/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220364060 | Theunissen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri); Whitehead Institute for Biomedical Research (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thorold Theunissen (St. Louis, Missouri); Shafqat Khan (St. Louis, Missouri); Rudolf Jaenisch (St. Louis, Missouri) |
| ABSTRACT | The present disclosure provides methods and compositions for inducing, maintaining and/or passaging naïve pluripotent stem cell. In some embodiments, the methods are performed in the absence of MEK inhibition which has been shown to result in genomic instability of naïve pluripotent stem cells. |
| FILED | Friday, May 13, 2022 |
| APPL NO | 17/744266 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0606 (20130101) C12N 5/0696 (20130101) Original (OR) Class C12N 2501/999 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220364061 | Lippmann et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ethan S. Lippmann (Nashville, Tennessee); Alejandra I. Romero-Morales (Nashville, Tennessee); Brian J. O'Grady (Nashville, Tennessee); Kylie M. Balotin (Nashville, Tennessee); Leon M. Bellan (Nashville, Tennessee); Vivian Gama (Nashville, Tennessee) |
| ABSTRACT | Bioreactor systems can include a first frame and a second frame, a well plate, a motor plate, a motor, and a controller. The first frame may define a well plate inset and standoff insets for a first set of metal standoffs. The second frame may define a plurality of mounts and a plurality of insets for a second set of metal standoffs. A gear may be positioned in each of the plurality of mounts. A paddle may be coupled to each of the gears. The well plate can be positioned within the well plate inset. The motor plate can be supported by and connected to the first set of metal standoffs and the second set of metal standoffs. The motor can be mounted on the motor plate and operatively connected to one of the plurality of gears. |
| FILED | Sunday, June 28, 2020 |
| APPL NO | 17/623391 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/12 (20130101) C12M 27/06 (20130101) C12M 41/14 (20130101) C12M 41/42 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0697 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220364071 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Feng Zhang (Cambridge, Massachusetts); Ian Slaymaker (Cambridge, Massachusetts); Soumya Kannan (Cambridge, Massachusetts); Jonathan Gootenberg (Cambridge, Massachusetts); Omar Abudayyeh (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides mutated Cas13 proteins and their use in modifying target sequences as well as mutated Cas13 nucleic acid sequences and vectors encoding mutated Cas13 proteins and vector systems or CRISPR-Cas13 systems. |
| FILED | Wednesday, July 31, 2019 |
| APPL NO | 17/264340 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/78 (20130101) Original (OR) Class C12N 15/111 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6823 (20130101) C12Q 1/6851 (20130101) Enzymes C12Y 305/04004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220364073 | Mali et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Prashant Mali (La Jolla, California); Nathan Palmer (La Jolla, California); Aditya Kumar (La Jolla, California); Amanda Suhardjo (La Jolla, California) |
| ABSTRACT | Described herein are methods for engineering proteins and viruses to reduce their immunogenicity, proteins and viruses made by using said methods, including proteins having Cas9 like activity and viruses having AAV5 like activity. |
| FILED | Tuesday, June 28, 2022 |
| APPL NO | 17/851972 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/10 (20130101) Original (OR) Class C12N 15/86 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220364079 | Meyerson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| INVENTOR(S) | Matthew Meyerson (Concord, Massachusetts); Mark N. Lee (Arlington, Massachusetts) |
| ABSTRACT | The present invention relates to a methods for high throughput screening of epitopes that are involved in T cell activation. |
| FILED | Wednesday, September 23, 2020 |
| APPL NO | 17/760532 |
| CURRENT CPC | Peptides C07K 14/70539 (20130101) C07K 16/246 (20130101) C07K 16/249 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1037 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220364083 | Ahangari et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yale University (New Haven, Connecticut); University of Connecticut (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Farida Ahangari (New Haven, Connecticut); Naftali Kaminski (New Haven, Connecticut); Carlos Fernandez-Hernando (New Haven, Connecticut); Raman Bahal (Glastonbury, Connecticut) |
| ABSTRACT | In one aspect, the present disclosure provides a microRNA-33 (miR-33) inhibitor comprising a peptide nucleic acid covalently bound to a pH low insertion peptide. In another aspect, the present disclosure provides a method of treating pulmonary fibrosis in a subject, the method comprising administering to the subject a therapeutically effective amount of the miR-33 inhibitor. In some embodiments, the pulmonary fibrosis is idiopathic pulmonary fibrosis. |
| FILED | Friday, May 13, 2022 |
| APPL NO | 17/663378 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) Original (OR) Class C12N 15/113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220364090 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Cincinnati (Cincinnati, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yigang Wang (Cincinnati, Ohio); Wei Huang (Cincinnati, Ohio) |
| ABSTRACT | Inhibitors of miRNA-128 capable of promoting cardiomyocyte mitotic cell proliferation and methods effective for regeneration of heart tissue. |
| FILED | Tuesday, May 17, 2022 |
| APPL NO | 17/746360 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0657 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/14 (20130101) C12N 2310/141 (20130101) C12N 2310/531 (20130101) C12N 2320/30 (20130101) C12N 2320/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220364095 | Mirkin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chad A. Mirkin (Wilmette, Illinois); Jasper Wilson Dittmar (Evanston, Illinois) |
| ABSTRACT | The disclosure is generally related to spherical nucleic acids (SNAs), structures comprising a nanoparticle core surrounded by a shell of oligonucleotides. In some aspects the disclosure provides a spherical nucleic acid (SNA) comprising: (a) a nanoparticle core; and (b) a shell of oligonucleotides attached to the nanoparticle core, wherein one or more oligonucleotides in the shell of oligonucleotides is attached to the nanoparticle core through a hydrophobic anchor comprising one or more dodecane (C12) subunits. Methods of making and using the SNAs are also provided herein. |
| FILED | Thursday, May 12, 2022 |
| APPL NO | 17/743422 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) A61K 2039/55505 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/117 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220364117 | Rodino-Klapac et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Louise Rodino-Klapac (Columbus, Ohio); Jerry R. Mendell (Columbus, Ohio) |
| ABSTRACT | The invention provides gene therapy vectors, such as adeno-associated virus (AAV) vectors, expressing a miniaturized human micro-dystrophin gene and method of using these vectors to express micro-dystrophin in skeletal muscles including diaphragm and cardiac muscle and to protect muscle fibers from injury, increase muscle strength and reduce and/or prevent fibrosis in subjects suffering from muscular dystrophy. |
| FILED | Friday, June 03, 2022 |
| APPL NO | 17/832325 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0029 (20130101) A61K 38/1709 (20130101) A61K 48/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220364118 | Mouradian et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey); Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey); Emory University (Atlanta, Georgia) |
| INVENTOR(S) | Mary M. Mouradian (Princeton, New Jersey); Stella Papa (Atlanta, Georgia); Jie Zhang (East Brunswick, New Jersey); Goichi Beck (Osaka, Japan) |
| ABSTRACT | Compositions, non-viral vectors, recombinant viruses, and recombinant viral vectors for inhibiting ΔFosB expression or activity in a cell and for treating dyskinesia in a subject (e.g., a human patient having Parkinson's disease and Levodopa-induced dyskinesia) include a nucleic acid sequence encoding a shRNA specific for ΔFosB. Methods of using these compositions, non-viral vectors, recombinant viruses, and recombinant viral vectors are also described herein. These compositions, non-viral vectors, recombinant viruses, and recombinant viral vectors and methods of use provide novel therapies for dyskinesia based on the reduction of ΔFosB expression and/or activity. |
| FILED | Monday, November 02, 2020 |
| APPL NO | 17/755504 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/14 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 15/861 (20130101) Original (OR) Class C12N 2750/14122 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220364119 | Weinberger et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The J. David Gladstone Institutes, a testamentary trust established under the Will of J.David Gladst (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Leor S. Weinberger (San Francisco, California); Elizabeth Tanner (San Francisco, California); Seung-Yong Jung (San Francisco, California) |
| ABSTRACT | The present disclosure provides interfering, conditionally replicating human immunodeficiency virus (HIV) constructs; infectious particles comprising the constructs; and compositions comprising the constructs or the particles. The constructs, particles, and compositions are useful in methods of reducing HIV viral load in an individual, which methods are also provided. |
| FILED | Friday, June 12, 2020 |
| APPL NO | 17/619063 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/76 (20130101) A61K 38/162 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/867 (20130101) Original (OR) Class C12N 2740/16032 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220364125 | Cannon et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paula Cannon (Los Angeles, California); Geoffrey Rogers (Los Angeles, California) |
| ABSTRACT | The disclosure describes a genome engineering strategy that allows for the production of secreted antibody fragments or non-immunoglobulin binding domains and the corresponding cell surface B cell receptor (BCR) from a human immunoglobulin (Ig) locus, and uses thereof. |
| FILED | Thursday, July 28, 2022 |
| APPL NO | 17/815711 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Peptides C07K 16/1045 (20130101) C07K 2317/76 (20130101) C07K 2317/569 (20130101) C07K 2317/622 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/102 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220364130 | Boville et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Christina E. Boville (Pasadena, California); Sabine Brinkmann-Chen (Glendale, California); Andrew R. Buller (Pasadena, California); David K. Romney (Pasadena, California); Christopher K. Prier (Brooklyn, New York); Philipp Koch (Basel, Switzerland); Remkes A. Scheele (Nijeveen, Netherlands) |
| ABSTRACT | The present disclosure provides methods for preparing β-substituted tryptophan compounds. The methods include: combining i) an unsubstituted indole or a substituted indole, ii) a β-substituted serine, and iii) a tryptophan synthase β-subunit (i.e., a TrpB); and maintaining the resulting mixture under conditions sufficient to form the β-substituted tryptophan. The TrpB contains at least one amino acid mutation which promotes formation of an amino-acrylate intermediate. New TrpB variants and new β-substituted tryptophan analogs are also described. |
| FILED | Monday, December 20, 2021 |
| APPL NO | 17/556555 |
| CURRENT CPC | Peptides C07K 14/415 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/88 (20130101) C12N 15/8254 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 13/04 (20130101) C12P 13/005 (20130101) C12P 13/06 (20130101) C12P 13/227 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220364135 | MOHAMADZADEH |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mansour MOHAMADZADEH (San Antonio, Texas) |
| ABSTRACT | The present disclosure is directed to modified Propionibacterium and methods of use (e.g., to produce vitamin B12). Methods of increasing vitamin B12 production in a bacterium comprising a vitamin B12 riboswitch are also contemplated. |
| FILED | Friday, August 28, 2020 |
| APPL NO | 17/637583 |
| CURRENT CPC | Peptides C07K 14/195 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/42 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220364142 | Mahajan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia); UNIVERSITY OF IOWA RESEARCH FOUNDATION (IOWA CITY, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vinit Mahajan (Redwood City, California); Gabriel Velez (Palo Alto, California); Young Joo Sun (Redwood City, California); Kellie A Schaefer (Redwood City, California); Alexander G Bassuk (Iowa City, Iowa) |
| ABSTRACT | Compositions, methods, and kits are provided for assaying calpain-5 activity and inhibition. In particular, novel peptide substrates are provided for detecting calpain-5, measuring calpain-5 activity, and screening for inhibitors of calpain-5 to identify potential therapeutic agents for treating retinal diseases and other diseases associated with calpain-5 hyperactivity. Additionally, novel inhibitors of calpain-5 are also provided. |
| FILED | Friday, October 09, 2020 |
| APPL NO | 17/767280 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) A61K 49/0008 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/37 (20130101) Original (OR) Class Enzymes C12Y 304/22 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2333/96466 (20130101) G01N 2500/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220364143 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Texas Tech University System (Lubbock, Texas); University of North Carolina - Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Degeng Wang (Lubbock, Texas); Leaf Huang (Durham, North Carolina); Hongjun Liang (Lubbock, Texas); Fengqian Chen (Baltimore, Maryland); Weimin Gao (Morgantown, West Virginia) |
| ABSTRACT | The present invention includes method and system for detecting kinase activity in vivo, comprising: providing a cell that comprises one or more mutated kinases, wherein the one or more mutated kinases comprise a mutation that enlarges an ATP binding pocket of the kinase; contacting the cell with an ATP analog-nanoparticle conjugate capable of intracellular delivery of the ATP analog-nanoparticle conjugate, wherein the ATP analog comprises a detectable label; culturing the cells under conditions in which the ATP analog-nanoparticle conjugate contacts the one or more mutated kinases in cellulo, wherein the detectable label is transferred from the ATP analog-nanoparticle conjugate to a substrate of the one or more mutated kinases, wherein the one or more kinases react to transfer the detectable label to the substrate. |
| FILED | Wednesday, May 11, 2022 |
| APPL NO | 17/741518 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/12 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/485 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2500/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220364173 | HE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | The University of Chicago (Chicago, Illinois) |
| INVENTOR(S) | Chuan HE (Chicago, Illinois); Lulu HU (Chicago, Illinois) |
| ABSTRACT | Aspects of the present disclosure relate to methods for modification and detection of methylated nucleotides. Embodiments are directed to detection of RNA methylation. Disclosed are methods and compositions for transcriptome-wide detection of N6-methyladenosine in mRNA. In some cases, methods for modifying a methylated nitrogenous base are described. Also disclosed are enzymes and other molecules useful for RNA methylation detection. |
| FILED | Friday, October 09, 2020 |
| APPL NO | 17/754622 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/154 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220364176 | Skinner et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington State University (Pullman, Washington); Seattle Children's Hospital DBA Seattle Children's Research Institute (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael K. Skinner (Pullman, Washington); Margarett Shnorhavorian (Seattle, Washington) |
| ABSTRACT | Provided herein are epigenetic modifications that are associated with prior exposure to chemotherapy agents. In particular, differential DNA methylation regions (DMRs) that are characteristic of, and can thus be used to identify and/or treat, a male subject who has undergone chemotherapy are provided. The DMRs are used to screen for pregnancy complications, infertility, and passage of heritable mutations to an infant. |
| FILED | Friday, July 22, 2022 |
| APPL NO | 17/870886 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/154 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220364179 | Prendergast |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lankenau Institute for Medical Research (Wynnewood, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George C. Prendergast (Penn Valley, Pennsylvania) |
| ABSTRACT | A method of predicting the responsiveness of a subject having a disease to a treatment with an inhibitor of Indoleamine 2,3-dioxygenase 2 (IDO), an inhibitor of tryptophan 2,3-dioxygenase (TDO), or an inhibitor of the IDO/TDO pathway and/or an additional therapy comprises performing a genotype assay to determine the presence, absence or mutation of the Indoleamine 2,3-dioxygenase 2 (ID02) gene at the single nucleotide polymorphism (SNP) site rs4503084 and the SNP site rs10109853. |
| FILED | Monday, September 14, 2020 |
| APPL NO | 17/642108 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220364184 | Carrasco et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| INVENTOR(S) | Ruben D. Carrasco (Waban, Massachusetts); Meng Jiang (Harbin, Heilongjiang, China PRC); Tomasz Sewastianik (Boston, Massachusetts) |
| ABSTRACT | The present invention relates to compositions and methods for diagnosing and treating colorectal cancer. |
| FILED | Thursday, September 24, 2020 |
| APPL NO | 17/761040 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/112 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220364187 | ALISCH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (MADISON, Wisconsin); ALBANY MEDICAL COLLEGE (ALBANY, New York) |
| ASSIGNEE(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (MADISON, Wisconsin); ALBANY MEDICAL COLLEGE (ALBANY, New York) |
| INVENTOR(S) | Reid S. ALISCH (Prairie du Sac, Wisconsin); Kirk J. HOGAN (Madison, Wisconsin); Andy MADRID (Madison, Wisconsin); Ariel JAITOVICH (Albany, New York) |
| ABSTRACT | Methods of detecting, predicting severity of, and/or predicting treatment response to respiratory virus infection in a sample obtained from a subject. The methods include assaying a methylation state of a marker in a sample obtained from a subject and identifying the subject as having respiratory virus infection, a likelihood of severe outcomes of respiratory infection, and/or a likelihood of treatment response depending on the methylation state of the marker. The markers can include bases (DMP) in differentially methylated regions (DMR) as provided herein. |
| FILED | Tuesday, May 17, 2022 |
| APPL NO | 17/746033 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/6888 (20130101) Original (OR) Class C12Q 2600/112 (20130101) C12Q 2600/118 (20130101) C12Q 2600/154 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220364269 | Xie |
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| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jingwei Xie (Omaha, Nebraska) |
| ABSTRACT | Expanded, nanofiber structures are provided as well as methods of use thereof and methods of making. |
| FILED | Tuesday, July 19, 2022 |
| APPL NO | 17/868519 |
| CURRENT CPC | Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/003 (20130101) D01D 5/0007 (20130101) Original (OR) Class D01D 5/0015 (20130101) D01D 5/0023 (20130101) D01D 5/0038 (20130101) D01D 5/0046 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 6/625 (20130101) D01F 8/14 (20130101) Making Textile Fabrics, e.g From Fibres or Filamentary Material; Fabrics Made by Such Processes or Apparatus, e.g Felts, Non-woven Fabrics; Cotton-wool; Wadding D04H 3/011 (20130101) Treatment, Not Provided for Elsewhere in Class D06, of Fibres, Threads, Yarns, Fabrics, Feathers or Fibrous Goods Made From Such Materials D06M 23/10 (20130101) D06M 2101/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220364991 | Wanunu et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Meni Wanunu (Sharon, Massachusetts); Fatemeh Farhangdoust (Allston, Massachusetts) |
| ABSTRACT | A method and system to decode information stored on a polymer sequence, such as a DNA strand, is described herein. The method and system use molecular probes to label sections of the polymer sequence. Each molecular probe includes a fluorophore and a quencher. The fluorophore produces light with a color and wavelength corresponding to the information stored on the section of the polymer sequence the molecular probe labels. The quencher inhibits the production of light by an adjacent fluorophore. When adjacent sections of the polymer sequence are labeled with molecular probes, the fluorophore of the leading molecular probe produces light while the trailing molecular probe's light is quenched. The method and system then sequentially unbind the molecular probes from the sections of the polymer sequence within a waveguide, producing a sequence of observable fluorescence signals. The sequence can be used to determine the information stored on a polymer sequence. |
| FILED | Thursday, March 24, 2022 |
| APPL NO | 17/703933 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) Original (OR) Class G01N 21/6458 (20130101) G01N 2021/6432 (20130101) G01N 2021/6439 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 50/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220365014 | Roussel, JR. et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas J. Roussel, JR. (Louisville, Kentucky); NIchola C. Garbett (Louisville, Kentucky); Alexa M. Melvin (Louisville, Kentucky) |
| ABSTRACT | A differential scanning calorimetry sensor, comprises a substrate; a heater trace comprising a conductive material, on the substrate; an encapsulation layer, on the substrate and on the heater trace; and a sample heating area, which is on the heater trace. The heater trace has a thickness of 50 to 1000 nm, a width of 1 to 100 pm, and a path length of 5 to 500 mm. Also described are a sample holder, a sensor enclosure and a thermal analysis sensor system. |
| FILED | Monday, October 26, 2020 |
| APPL NO | 17/771487 |
| CURRENT CPC | Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 17/006 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 25/4813 (20130101) G01N 25/4866 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220365028 | MEYER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jesse MEYER (Milwaukee, Wisconsin); Joshua COON (Middleton, Wisconsin); Alexander HEBERT (Malvern, Pennsylvania); Caleb CRANNEY (Provo, Utah) |
| ABSTRACT | The present invention provides methods and systems using gas-phase separation with mass spectrometry analysis instead of liquid chromatography, thereby enabling faster peptide, proteome, and multi-omic analysis. Also provided are improved methods and software for data independent acquisition. One embodiment referred to as Direct Infusion—Shotgun Proteome Analysis (DI-SPA) used with data-independent acquisition mass spectrometry (DIA-MS), resulted in targeted quantification of over 500 proteins within minutes of MS data collection (˜3.5 proteins/second). Enabling fast, unbiased protein and proteome quantification without liquid chromatography, DI-SPA offers a new approach to boosting throughput critical to drug and biomarker discovery studies that require analysis of thousands of proteomes. This invention is also able to perform complex multi-omic analysis of proteomes, lipidomes, and metabolomes on a single platform. |
| FILED | Tuesday, May 10, 2022 |
| APPL NO | 17/741277 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/64 (20130101) Original (OR) Class G01N 27/623 (20210101) G01N 27/624 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/0031 (20130101) H01J 49/0036 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220365097 | Lim et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | AmberGen, Inc. (Watertown, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark J. Lim (Reading, Massachusetts); Gargey Yagnik (Hopkinton, Massachusetts); Kenneth J. Rothschild (Newton, Massachusetts) |
| ABSTRACT | The field of this invention relates to immunohistochemistry (IHC) and in situ hybridization (ISH) for the targeted detection and mapping of biomolecules (e.g., proteins and miRNAs) in tissues or cells for example, for research use and for clinical use such by pathologists (e.g., biomarker analyses of a resected tumor or tumor biopsy). In particular, the use of mass spectrometric imaging (MSI) as a mode to detect and map the biomolecules in tissues or cells for example. More specifically, the field of this invention relates to photocleavable mass-tag reagents which are attached to probes such as antibodies and nucleic acids and used to achieve multiplex immunohistochemistry and in situ hybridization, with MSI as the mode of detection/readout. Probe types other than antibodies and nucleic acids are also covered in the field of invention, including but not limited to carbohydrate-binding proteins (e.g., lectins), receptors and ligands. Finally, the field of the invention also encompasses multi-omic MSI procedures, where MSI of photocleavable mass-tag probes is combined with other modes of MSI, such as direct label-free MSI of endogenous biomolecules from the biospecimen (e.g., tissue), whereby said biomolecules can be intact or digested (e.g., chemically digested or by enzyme). |
| FILED | Tuesday, July 12, 2022 |
| APPL NO | 17/862990 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 271/20 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6841 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6851 (20130101) Original (OR) Class G01N 2400/00 (20130101) G01N 2458/15 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220365098 | Lim et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | AmberGen, Inc. (Watertown, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark J. Lim (Reading, Massachusetts); Gargey Yagnik (Hopkinton, Massachusetts); Kenneth J. Rothschild (Newton, Massachusetts) |
| ABSTRACT | The field of this invention relates to immunohistochemistry (IHC) and in situ hybridization (ISH) for the targeted detection and mapping of biomolecules (e.g., proteins and miRNAs) in tissues or cells for example, for research use and for clinical use such by pathologists (e.g., biomarker analyses of a resected tumor or tumor biopsy). In particular, the use of mass spectrometric imaging (MSI) as a mode to detect and map the biomolecules in tissues or cells for example. More specifically, the field of this invention relates to photocleavable mass-tag reagents which are attached to probes such as antibodies and nucleic acids and used to achieve multiplex immunohistochemistry and in situ hybridization, with MSI as the mode of detection/readout. Probe types other than antibodies and nucleic acids are also covered in the field of invention, including but not limited to carbohydrate-binding proteins (e.g., lectins), receptors and ligands. Finally, the field of the invention also encompasses multi-omic MSI procedures, where MSI of photocleavable mass-tag probes is combined with other modes of MSI, such as direct label-free MSI of endogenous biomolecules from the biospecimen (e.g., tissue), whereby said biomolecules can be intact or digested (e.g., chemically digested or by enzyme). |
| FILED | Wednesday, July 13, 2022 |
| APPL NO | 17/863928 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 271/20 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6841 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6851 (20130101) Original (OR) Class G01N 2400/00 (20130101) G01N 2458/15 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220365157 | Saggar |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Manish Saggar (Stanford, California) |
| ABSTRACT | Systems and methods for mapping neuronal circuitry in accordance with embodiments of the invention are illustrated. One embodiment includes a method for generating a neuronal shape graph, including obtaining functional brain imaging data from an imaging device, where the functional brain imaging data includes a time-series of voxels describing neuronal activation over time in a patient's brain, lowering the dimensionality of the functional brain imaging data to a set of points, where each point represents the brain state at a particular time in the timeseries, binning the points into a plurality of bins, clustering the binned points, and generating a shape graph from the clustered points, where nodes in the shape graph represent a brain state and edges between the nodes represent transitions between brain states. |
| FILED | Monday, May 16, 2022 |
| APPL NO | 17/663654 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/16 (20130101) A61B 5/0042 (20130101) A61B 5/055 (20130101) A61B 5/165 (20130101) A61B 5/369 (20210101) A61B 5/743 (20130101) A61B 5/4064 (20130101) A61B 5/7264 (20130101) A61B 2576/026 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/4806 (20130101) Original (OR) Class G01R 33/5608 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6224 (20130101) G06K 9/6297 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 7/50 (20170101) G06T 2207/10088 (20130101) G06T 2207/30016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220365642 | Karp et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SRI International (Menlo Park, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter D. Karp (San Mateo, California); Suzanne M. Paley (Redwood City, California) |
| ABSTRACT | This disclosure describes techniques for generating a visual path through a metabolic network, techniques include receiving reaction data for a starting metabolite, the reaction data comprising one or more potential reaction steps of the starting metabolite with one or more neighbor metabolites, generating from the one or more neighbor metabolites, a precursor metabolite list of precursor metabolites and a successor metabolite list of successor metabolites based on the reaction data, generating a user interface comprising the visual path that includes interactive visual data, the interactive visual data indicating each metabolite from the precursor metabolite list and the successor metabolite list, wherein each metabolite from the precursor metabolite list and the successor metabolite list is selectable and indicates a corresponding potential reaction step of the one or more potential reaction steps of the starting metabolite, and outputting the user interface for display at a display device. |
| FILED | Thursday, April 21, 2022 |
| APPL NO | 17/660158 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/0482 (20130101) G06F 3/0484 (20130101) Original (OR) Class Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) G16B 40/20 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220366313 | Gundlach et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Jens H. Gundlach (Seattle, Washington); Matthew Noakes (Seattle, Washington); Henry D. Brinkerhoff (Seattle, Washington) |
| ABSTRACT | In some embodiments, a computer-implemented method of determining an identity of one or more monomer subunit residues of a polymer analyte is provided, In some embodiments, a raw current signal generated by using a variable voltage to translocate the polymer analyte through a nanopore. In some embodiments, change points are detected in the raw current signal to determine a series of states, In some embodiments, capacitance compensation is performed on the raw current signal for each state to create an ionic current-vs-voltage curve for each state. In some embodiments, the ionic current-vs-voltage curves is converted to conductance-vs-voltage curves. In some embodiments, filtering is performed for the series of states to create a series of filtered states. In some embodiments, the identity of one or more monomer subunit residues of the polymer analyte is determined based on the series of filtered states. |
| FILED | Friday, February 14, 2020 |
| APPL NO | 17/430695 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/48721 (20130101) Computer Systems Based on Specific Computational Models G06N 20/10 (20190101) Original (OR) Class G06N 20/20 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220366803 | Tunik et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University Center for Research Innovation, Northeastern Univ. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eugene Tunik (Windham, New Hampshire); Mathew Yarossi (Medford, Massachusetts); Samuel Berin (Boston, Massachusetts) |
| ABSTRACT | Computer-implemented methods and systems are disclosed for designing and conducting virtual reality experiments. The method includes the steps of: (a) providing a configuration user interface through a computer system enabling a user to design a virtual reality experiment by integrating one or more peripheral sensors in an immersive virtual environment; (b) running the virtual reality experiment configured in step (a) and collecting experiment data from the one or more peripheral sensors; and (c) outputting the experiment data. |
| FILED | Monday, May 16, 2022 |
| APPL NO | 17/745272 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/011 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 5/02 (20130101) Original (OR) Class G09B 19/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220367163 | Krutchinsky et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Rockefeller University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Krutchinsky (New York, New York); Brian Chait (New York, New York) |
| ABSTRACT | A parallel multi-beam mass spectrometer includes an ion trap and a single multi-beam time-of-flight analyzer. The trap has a plurality of alternating electrodes configured to form a plurality of quadrupoles defining a surface of the trap, wherein at least two of the plurality of quadrupoles are configured as mass filters for selective ejection of concurrent parallel beams of ions from the trap in respective predetermined ion mass-to-charge windows. The single multi-beam time-of-flight analyzer has a position sensitive detector or a plurality of individual detectors for simultaneously receiving and analyzing the concurrent parallel beams of ions. |
| FILED | Tuesday, May 24, 2022 |
| APPL NO | 17/752099 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 49/009 (20130101) Original (OR) Class H01J 49/40 (20130101) H01J 49/4225 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20220361782 | Galagan et al. |
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| FUNDED BY |
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| APPLICANT(S) | Trustees of Boston University (Boston, Massachusetts) |
| ASSIGNEE(S) | Trustees of Boston University (Boston, Massachusetts) |
| INVENTOR(S) | James Galagan (Needham, Massachusetts); Uros Kuzmanovic (Brookline, Massachusetts) |
| ABSTRACT | Disclosed is a hormone electrochemical biosensor, e.g. an amperometric biosensor, for the detection of a hormone and measurement of the concentration of a hormone. The disclosed hormone biosensor comprises a hormone-catalyzing enzyme, such as KSDH1. Also described herein are systems comprising an amperometric biosensor, e.g., chronoamperometric biosensor and methods of using the chronoamperometric biosensor. |
| FILED | Saturday, April 30, 2022 |
| APPL NO | 17/734042 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/1451 (20130101) A61B 5/1477 (20130101) A61B 5/1486 (20130101) A61B 5/14517 (20130101) A61B 5/14546 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220361789 | Yeo |
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| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Woon-Hong Yeo (Atlanta, Georgia) |
| ABSTRACT | An exemplary embodiment of the present disclosure provides a method of determining stress levels in a user comprising: receiving galvanic skin response (GSR) measurements by a wearable sensor on the user over a period of time; receiving temperature measurements by the wearable sensor on the user over the period of time; determining changes in the temperature over a predetermined threshold in the temperature measurements over the period of time; calibrating the GSR measurements based on the determined changes in temperature over the predetermined threshold; calculating a stress level of the user based on the calibrated GSR measurements; and generating an output indicative of the calculated stress level. |
| FILED | Monday, June 14, 2021 |
| APPL NO | 17/346778 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/165 (20130101) Original (OR) Class A61B 5/0533 (20130101) A61B 5/681 (20130101) A61B 5/6826 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220361917 | MEENAKSHISUNDARAM |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania) |
| INVENTOR(S) | RAVI SHANKAR MEENAKSHISUNDARAM (ASPINWALL, Pennsylvania) |
| ABSTRACT | An optically transparent actuator apparatus is provided that includes an optically transparent bi-stable member including an optically transparent liquid crystalline polymer layer. The bi-stable member is structured to move from a first state to a second state in response to a first stimulus and from the second state to the first state in response to a second stimulus. Also, a display apparatus includes a plate member and an actuator assembly coupled to the plate member. The actuator assembly includes a number of optically transparent liquid crystalline polymer layers, wherein each of the optically transparent liquid crystalline polymer layers is structured to move from a first state to a second state in response to a first stimulus. |
| FILED | Monday, July 11, 2022 |
| APPL NO | 17/811619 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/00154 (20130101) A61B 17/32 (20130101) A61B 17/34 (20130101) A61B 17/3423 (20130101) A61B 17/3476 (20130101) Original (OR) Class A61B 18/00 (20130101) A61B 18/08 (20130101) A61B 18/12 (20130101) A61B 18/1487 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 19/38 (20130101) C09K 19/0208 (20130101) Electric Digital Data Processing G06F 3/016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362094 | De Rossi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Boston University (Boston, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Trustees of Boston University (Boston, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Stefano Marco Maria De Rossi (Cambridge, Massachusetts); Kathleen E. O'Donnell (Cambridge, Massachusetts); Jaehyun Bae (Cambridge, Massachusetts); Alan Thomas Asbeck (Cambridge, Massachusetts); Kenneth G. Holt (Shutesbury, Massachusetts); Conor J. Walsh (Cambridge, Massachusetts) |
| ABSTRACT | In at least some aspects, the present concepts include a method for configuring an assistive flexible suit including the acts of outfitting a person with an assistive flexible suit, monitoring an output of at least one sensor of the assistive flexible suit as the person moves in a first controlled movement environment, identifying at least one predefined gait event using the output of the at least one sensor, adjusting an actuation profile of the at least one actuator and continuing to perform the acts of monitoring, identifying and adjusting until an actuation profile of the at least one actuator generates a beneficial moment about the at least one joint to promote an improvement in gait. The at least one controller is then set to implement the actuation profile. |
| FILED | Monday, April 04, 2022 |
| APPL NO | 17/712578 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/112 (20130101) A61B 5/4851 (20130101) A61B 5/6811 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/72 (20130101) A61F 5/0102 (20130101) A61F 5/0127 (20130101) A61F 13/08 (20130101) A61F 2005/0155 (20130101) A61F 2005/0158 (20130101) A61F 2005/0179 (20130101) A61F 2005/0188 (20130101) Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 1/024 (20130101) A61H 1/0244 (20130101) A61H 1/0266 (20130101) A61H 3/00 (20130101) Original (OR) Class A61H 2201/14 (20130101) A61H 2201/164 (20130101) A61H 2201/165 (20130101) A61H 2201/169 (20130101) A61H 2201/501 (20130101) A61H 2201/1207 (20130101) A61H 2201/1623 (20130101) A61H 2201/1628 (20130101) A61H 2201/5028 (20130101) A61H 2201/5061 (20130101) A61H 2201/5064 (20130101) A61H 2201/5079 (20130101) A61H 2201/5084 (20130101) A61H 2230/60 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362236 | Trotti et al. |
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| FUNDED BY |
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| APPLICANT(S) | Thomas Jefferson University (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Davide Trotti (Bala Cynwyd, Pennsylvania); Piera Pasinelli (Bala Cynwyd, Pennsylvania); Michael R. Jablonski (Philadelphia, Pennsylvania) |
| ABSTRACT | The present invention provides a method of treating or ameliorating a neurodegenerative disease in a mammal, the method comprising administering to the mammal a therapeutically effective amount of a neurodegenerative disease drug, wherein the drug is a substrate of an ABC transporter inhibitor, wherein the mammal is further administered a therapeutically effective amount of an ARC transporter inhibitor, whereby the neurodegenerative disease is treated in the mammal. In certain embodiments, the neurode generative disease comprises at least one selected from the group consisting of spinal cord injury, Alzheimer's disease, Parkinson's disease, Huntington's disease, prion disease, amyotrophic lateral sclerosis, a tauopathy, and chronic traumatic encephalopathy. |
| FILED | Monday, May 23, 2022 |
| APPL NO | 17/750848 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/55 (20130101) A61K 31/428 (20130101) A61K 31/473 (20130101) Original (OR) Class A61K 31/496 (20130101) A61K 31/4725 (20130101) A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362374 | MATYAS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States, as represented by the Secretary of the Army (Fort Detrick, Maryland); The United States of America, as represented by the Secretary, Department of Health (Bethesda, Maryland) |
| ASSIGNEE(S) | The Government of the United States, as represented by the Secretary of the Army (Fort Detrick, Maryland); The United States of America, as represented by the Secretary, Department of Health (Bethesda, Maryland) |
| INVENTOR(S) | Gary R. MATYAS (Olney, Maryland); Rodell C. BARRIENTOS (Rockville, Maryland); Oscar B. TORRES (Rockville, Maryland); Connor WHALEN (Cranberry Township, Pennsylvania); Therese OERTEL (Silver Spring, Maryland); Kenner C. RICE (Bethesda, Maryland); Arthur E. JACOBSON (Rockville, Maryland); Eric W. BOW (Washington, District of Columbia); Agnieszka SULIMA (Poolesville, Maryland) |
| ABSTRACT | The present disclosure is directed to isolated recombinant antibodies, or antigen-binding fragments thereof, that bind to fentanyl or fentanyl analogs. The novel antibodies or antigen-binding fragments thereof can be used to detect, diagnose, treat, and/or prevent opioid use disorder. |
| FILED | Thursday, April 28, 2022 |
| APPL NO | 17/661160 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0013 (20130101) A61K 39/385 (20130101) Original (OR) Class A61K 47/646 (20170801) A61K 47/6415 (20170801) A61K 2039/505 (20130101) A61K 2039/6012 (20130101) A61K 2039/6037 (20130101) A61K 2039/55505 (20130101) A61K 2039/55572 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/36 (20180101) Peptides C07K 16/44 (20130101) C07K 2317/24 (20130101) C07K 2317/76 (20130101) C07K 2317/565 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362587 | Puleo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Michael Puleo (Niskayuna, New York); Victoria Eugenia Cotero (Troy, New York); Jeffrey Michael Ashe (Gloversville, New York); John Frederick Graf (Ballston Lake, New York) |
| ABSTRACT | Embodiments of the present disclosure relate to techniques for inducing physiological perturbations in a subject via neuromodulation, e.g., peripheral neuromodulation of a region of interest of an organ. The nature and degree of the perturbations may be related to the subject's clinical condition. Accordingly, an assessment of one or more characteristics of the perturbations may be used to determine a clinical condition of the subject. |
| FILED | Wednesday, July 13, 2022 |
| APPL NO | 17/864212 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0536 (20130101) A61N 1/36017 (20130101) A61N 7/00 (20130101) Original (OR) Class A61N 2007/0026 (20130101) A61N 2007/0073 (20130101) A61N 2007/0078 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362767 | Kashkin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Fabrico Technology, Inc. (Georgetown, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alex Kashkin (Cambridge, Massachusetts); Joseph Oleniczak (Austin, Texas); Robert Chin (Austin, Texas) |
| ABSTRACT | A system includes a cartridge and an instrument. The cartridge includes a cartridge body defining an input port aligned with a central axis of the cartridge body, a plurality of channels in fluidic communication with the input port and extending radially to a plurality of reaction chamber connectors, a plurality of reaction chambers disposed at a radial distance from the central axis of the cartridge body and distributed at angles relative to the others of the plurality of reaction chambers. The system further includes an instrument including an incubation block configured to receive the plurality of reaction chambers; a motor and socket to connect with the cartridge; an illumination source having an illumination pathway; and a camera disposed in a signal pathway intersecting the illumination pathway. |
| FILED | Sunday, October 25, 2020 |
| APPL NO | 17/771771 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) Original (OR) Class B01L 2200/16 (20130101) B01L 2200/0684 (20130101) B01L 2300/0832 (20130101) Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/51 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362769 | Reiserer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ronald S. Reiserer (Nashville, Tennessee); David K. Schaffer (Nashville, Tennessee); Philip C. Samson (Nashville, Tennessee); Dmitry A. Markov (Nashville, Tennessee); Michael Geuy (Nashville, Tennessee); Lisa J. McCawley (Nashville, Tennessee); John P. Wikswo (Brentwood, Tennessee) |
| ABSTRACT | Microfluidic systems, pumps, valves and applications of the same are provided. The microfluidic system may be a pump or a valve having a fluidic chip and an actuator controlling the opening and closing of the fluidic channel in the fluidic chip. The actuator may be disposed to tilt from the fluidic chip, forming a tilted-rotor peristaltic pump. Alternatively, the actuator may be a rolling ball actuator, and different fluidic chips may be used in different applications. For example, the fluidic chip may be a spiral pump chip having spiral channels, a rotary peristaltic pump chip having multiple output channels, or a multi-port valve chip having one port interconnected with multiple different ports. An analytical valve chip may switchably interconnect bioreactor and rinse/calibration input channels to sensor and waste output channels. The actuator of a random-access valve can move from one valve position to another without opening or closing intermediate ones. |
| FILED | Monday, June 29, 2020 |
| APPL NO | 17/623350 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502738 (20130101) Original (OR) Class B01L 2300/123 (20130101) B01L 2300/0627 (20130101) B01L 2400/0644 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362971 | Das et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Suman Das (Atlanta, Georgia); Dajun Yuan (San Diego, California); Anirudh Rudraraju (Hillsboro, Oregon); Paul Cilino (Atlanta, Georgia) |
| ABSTRACT | A system including a container for holding a photosensitive medium adapted to change states upon exposure to a light source, an optical imaging system, configured to move above the container holding the photosensitive medium, and having the light source, and a control system configured to: slice a digital model of a three-dimensional object into a slice having a cross-section, generate a build cross-section by filling a two-dimensional image with one or more copies of the cross-section, add to the build cross-section a conformal lattice to fill space in the build cross-section around the one or more copies of the cross-section, and control movement of the optical imaging system above the container to cure a portion of the photosensitive medium corresponding to the build cross-section to produce a layer of a three-dimensional object. |
| FILED | Monday, March 21, 2022 |
| APPL NO | 17/655782 |
| CURRENT CPC | Foundry Moulding B22C 9/02 (20130101) B22C 9/10 (20130101) B22C 9/24 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 35/0805 (20130101) Original (OR) Class B29C 64/40 (20170801) B29C 64/129 (20170801) B29C 64/135 (20170801) B29C 2035/0827 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 50/02 (20141201) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/70291 (20130101) G03F 7/70416 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 10/25 (20151101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220363572 | Baker |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | U.S. Army Combat Capabilities Development Command, Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David R. Baker (Silver Spring, Maryland) |
| ABSTRACT | Apparatus and method for electrolysis of urea is capable of removing urea from waste-water generated by human urine or agricultural run-off while simultaneously producing cleaner water and hydrogen gas. The apparatus and method employ at least one water reduction electrode located close to at least one urea oxidation electrode. The water reduction electrode operates to generate a locally high pH such that the urea oxidation electrode operates in a locally high pH envelope where it can perform its reaction efficiently to break down the urea with little or no impact on the pH of the bulk solution. |
| FILED | Thursday, May 13, 2021 |
| APPL NO | 17/319203 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/4672 (20130101) C02F 1/46109 (20130101) Original (OR) Class C02F 2001/46133 (20130101) C02F 2101/38 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220363633 | Schiltz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gary E. Schiltz (Naperville, Illinois); Jindan Yu (Evanston, Illinois) |
| ABSTRACT | Disclosed are substituted pyrrolidones and piperidones which may be utilized as EZH2 targeting agents. The substituted pyrrolidones and piperidones may include substituted 2-pyrrolidones and 2-piperidones. The disclosed pyrrolidones and piperidones may be used in pharmaceutical compositions and methods for treating cell proliferative disorders such as cancer. |
| FILED | Friday, April 29, 2022 |
| APPL NO | 17/733513 |
| CURRENT CPC | Heterocyclic Compounds C07D 207/27 (20130101) C07D 207/273 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220364030 | Hinojosa et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher David Hinojosa (Cambridge, Massachusetts); Josiah Sliz (Cambridge, Massachusetts); Daniel Levner (Cambridge, Massachusetts); Guy Thompson (Cambridge, Massachusetts); Hubert Geisler (Cambridge, Massachusetts); Jose Fernandez-Alcon (Cambridge, Massachusetts); Donald E. Ingber (Cambridge, Massachusetts) |
| ABSTRACT | Systems and methods for improved flow properties in fluidic and microfluidic systems are disclosed. The system includes a microfluidic device having a first microchannel, a fluid reservoir having a working fluid and a pressurized gas, a pump in communication with the fluid reservoir to maintain a desired pressure of the pressurized gas, and a fluid-resistance element located within a fluid path between the fluid reservoir and the first microchannel. The fluid-resistance element includes a first fluidic resistance that is substantially larger than a second fluidic resistance associated with the first microchannel. |
| FILED | Thursday, July 28, 2022 |
| APPL NO | 17/876283 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5027 (20130101) B01L 3/50273 (20130101) B01L 3/502715 (20130101) B01L 3/502746 (20130101) B01L 2200/027 (20130101) B01L 2200/0605 (20130101) B01L 2200/0684 (20130101) B01L 2300/14 (20130101) B01L 2300/044 (20130101) B01L 2300/0681 (20130101) B01L 2300/0816 (20130101) B01L 2300/0864 (20130101) B01L 2300/0867 (20130101) B01L 2400/084 (20130101) B01L 2400/0487 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 15/00 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) C12M 23/16 (20130101) Original (OR) Class C12M 33/12 (20130101) C12M 41/00 (20130101) C12M 41/40 (20130101) C12M 41/46 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220364049 | Rizzolo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lawrence Rizzolo (Guilford, Connecticut); Deepti Singh (East Haven, Connecticut) |
| ABSTRACT | The present invention provides a scaffold for culturing retinal tissue comprising an amount of gelatin, an amount of chondroitin sulfate, an amount of hyaluronic acid, wherein the amount of gelatin, chondroitin sulfate, and hyaluronic acid are prepared into a three-dimensional monolith, wherein the monolith is sectioned into planar sheets, and an amount of laminin-521. |
| FILED | Tuesday, June 21, 2022 |
| APPL NO | 17/845461 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/26 (20130101) A61L 27/50 (20130101) A61L 27/54 (20130101) A61L 27/56 (20130101) A61L 27/3604 (20130101) A61L 27/3834 (20130101) A61L 27/3886 (20130101) A61L 27/3891 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0062 (20130101) Original (OR) Class C12N 5/0606 (20130101) C12N 5/0621 (20130101) C12N 5/0696 (20130101) C12N 2513/00 (20130101) C12N 2533/52 (20130101) C12N 2533/54 (20130101) C12N 2533/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220364095 | Mirkin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chad A. Mirkin (Wilmette, Illinois); Jasper Wilson Dittmar (Evanston, Illinois) |
| ABSTRACT | The disclosure is generally related to spherical nucleic acids (SNAs), structures comprising a nanoparticle core surrounded by a shell of oligonucleotides. In some aspects the disclosure provides a spherical nucleic acid (SNA) comprising: (a) a nanoparticle core; and (b) a shell of oligonucleotides attached to the nanoparticle core, wherein one or more oligonucleotides in the shell of oligonucleotides is attached to the nanoparticle core through a hydrophobic anchor comprising one or more dodecane (C12) subunits. Methods of making and using the SNAs are also provided herein. |
| FILED | Thursday, May 12, 2022 |
| APPL NO | 17/743422 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) A61K 2039/55505 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/117 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220364119 | Weinberger et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The J. David Gladstone Institutes, a testamentary trust established under the Will of J.David Gladst (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Leor S. Weinberger (San Francisco, California); Elizabeth Tanner (San Francisco, California); Seung-Yong Jung (San Francisco, California) |
| ABSTRACT | The present disclosure provides interfering, conditionally replicating human immunodeficiency virus (HIV) constructs; infectious particles comprising the constructs; and compositions comprising the constructs or the particles. The constructs, particles, and compositions are useful in methods of reducing HIV viral load in an individual, which methods are also provided. |
| FILED | Friday, June 12, 2020 |
| APPL NO | 17/619063 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/76 (20130101) A61K 38/162 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/867 (20130101) Original (OR) Class C12N 2740/16032 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220364120 | Han et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Texas A and M University System (College Station, Texas); U.S. Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arum Han (College Station, Texas); Jose Wippold (Bryan, Texas); Bryn L. Adams (Silver Spring, Maryland) |
| ABSTRACT | In an embodiment, the present disclosure pertains to a microfluidic platform composed of a droplet generator having an entry point for donor particles and target particles, a first droplet incubation chamber in fluid communication with the droplet generator, a droplet detection functionality to allow for analysis of the inner content of droplets, and a droplet sorting functionality to allow for the separation of droplets based on the analysis of the inner content of droplets. In another embodiment, the present disclosure pertains to a method for cell-to-cell DNA, RNA, or other genetic material transfer through use of a water-in-oil emulsion microdroplet-based microfluidic platform for automation and high throughput identification or screening of genetic transfer outcomes utilizing the microfluidic platforms as disclosed herein. |
| FILED | Monday, May 16, 2022 |
| APPL NO | 17/745488 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502784 (20130101) B01L 2200/16 (20130101) B01L 2200/0673 (20130101) B01L 2300/0636 (20130101) B01L 2400/084 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/88 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220364582 | Hasegawa et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF NOTRE DAME (South Bend, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mitsugu Hasegawa (Notre Dame, Indiana); Hirotaka Sakaue (Notre Dame, Indiana) |
| ABSTRACT | In one aspect of the present disclosure, a streamlined body for passing through a fluid is provided. The streamlined body includes an outer surface defining a leading edge and a trailing edge. The leading edge is oriented to pass through the fluid before the trailing edge during movement of the body through the fluid. The streamlined body further includes a plurality of fibers coupled to the outer surface. Each fiber of the plurality of fibers projects away from the outer surface. |
| FILED | Tuesday, January 08, 2019 |
| APPL NO | 16/960688 |
| CURRENT CPC | Ships or Other Waterborne Vessels; Equipment for Shipping B63B 5/24 (20130101) B63B 2005/242 (20130101) Aeroplanes; Helicopters B64C 1/0009 (20130101) Fluid Dynamics, i.e Methods or Means for Influencing the Flow of Gases or Liquids F15D 1/003 (20130101) Original (OR) Class F15D 1/06 (20130101) F15D 1/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220364727 | Rudrapatna et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | HONEYWELL INTERNATIONAL INC. (Charlotte, North Carolina) |
| ASSIGNEE(S) | HONEYWELL INTERNATIONAL INC. (Charlotte, North Carolina) |
| INVENTOR(S) | Nagaraja Rudrapatna (Phoenix, Arizona); Rodolphe Dudebout (Phoenix, Arizona) |
| ABSTRACT | A coating occlusion resistant effusion cooling hole to form a film of a cooling fluid on a surface of a wall. The cooling hole extends along a longitudinal axis. The cooling hole includes an inlet section defined so as to be spaced apart from the surface. The inlet section is to receive the cooling fluid. The cooling hole includes a metering section fluidly coupled downstream of the inlet section. The cooling hole includes an outlet section fluidly coupled downstream of the metering section. The outlet section includes an overhang portion, a recessed portion, a first sidewall and a second sidewall. The first sidewall and the second sidewall interconnect the overhang portion with the recessed portion along a portion of the outlet section, and the first sidewall and the second sidewall converge and diverge in a plane transverse to the longitudinal axis. |
| FILED | Tuesday, May 11, 2021 |
| APPL NO | 17/317589 |
| CURRENT CPC | Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/18 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2240/35 (20130101) F05D 2260/202 (20130101) F05D 2260/232 (20130101) Generating Combustion Products of High Pressure or High Velocity, e.g Gas-turbine Combustion Chambers F23R 3/002 (20130101) Original (OR) Class F23R 2900/03041 (20130101) F23R 2900/03042 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220364954 | Feirer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of South Carolina (Columbia, South Carolina) |
| ASSIGNEE(S) | University of South Carolina (Columbia, South Carolina) |
| INVENTOR(S) | Brenna Feirer (Columbia, South Carolina); Paul Ziehl (Irmo, South Carolina); Rafal Anay (Columbia, South Carolina) |
| ABSTRACT | Described herein are acoustic emission damage classification methods and systems employing intensity analysis to monitor the state of rotating machinery to classify the damage occurring to a mechanical object. |
| FILED | Tuesday, November 23, 2021 |
| APPL NO | 17/533244 |
| CURRENT CPC | Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 13/045 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220365206 | Rodenbeck et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher T. Rodenbeck (Annandale, Virginia); Joshua B. Beun (Alexandria, Virginia); Ronald D. Lipps (San Diego, California); Raghu G. Raj (Fairfax, Virginia) |
| ABSTRACT | Systems and methods are provided for interrogating a moving acoustic source using radar and processing data using a selection of motion compensation techniques adapted from synthetic aperture radar (SAR) to remove the effects of linear and nonlinear target motion so that the range-Doppler map retains only vibration information in the Doppler dimension. Vibration and sound waveforms can thus be selectively reproduced at specific ranges directly from the radar baseband waveform, without the need for additional complex analysis or audio processing. |
| FILED | Wednesday, August 18, 2021 |
| APPL NO | 17/406040 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 13/89 (20130101) Original (OR) Class G01S 13/582 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220365223 | Kling et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew T. Kling (Burlington, Massachusetts); Daniel Lau (Burlington, Massachusetts); Kenneth Lile Witham (Malden, Massachusetts); Pau Closas (Boston, Massachusetts); Gerald Mycko LaMountain (Malden, Massachusetts) |
| ABSTRACT | In an embodiment, a method monitors, within a global navigation satellite system (GNSS) limited zone, an intra-zone location of a vehicle having a GNSS receiver, the intra-zone location being within the limited zone. The method determines a simulated intra-zone location of the vehicle based on the intra-zone location monitored to calculate a likely location of the vehicle. The method calculates a global location of the vehicle based on the intra-zone location and the location of the GNSS limited zone within a global network of limited zones. The method broadcasts, from a transmitter within the GNSS limited zone, a GNSS signal representing the global location of the vehicle. |
| FILED | Tuesday, May 10, 2022 |
| APPL NO | 17/662822 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 19/03 (20130101) G01S 19/26 (20130101) Original (OR) Class G01S 19/37 (20130101) Wireless Communication Networks H04W 4/021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220365848 | Hornung et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Mcron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bryan Hornung (Plano, Texas); David Patrick (McKinney, Texas) |
| ABSTRACT | Systems, apparatuses, and methods related to chiplets are described. A chiplet-based system may include a memory controller chiplet to control accesses to a storage array, and the memory controller chiplet can facilitate error correction and cache management in a manner to minimize interruptions to a sequence of data reads to write corrected data from a prior read back into the storage array. For example, a read command may be received at a memory controller device of the memory system from a requesting device. Data responsive to the read command may be obtained and determined to include a correctable error. The data may be corrected, transmitted to the requesting device and written to cache of the memory controller device with an indication that data is valid and dirty (e.g., includes an error or corrected error). The data is written back to the memory array in response to a cache eviction event. |
| FILED | Wednesday, July 27, 2022 |
| APPL NO | 17/874483 |
| CURRENT CPC | Electric Digital Data Processing G06F 11/106 (20130101) G06F 11/1068 (20130101) Original (OR) Class G06F 11/3037 (20130101) G06F 12/0246 (20130101) G06F 12/0891 (20130101) G06F 13/1668 (20130101) G06F 2212/7209 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220365862 | Shao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | Yale University (New Haven, Connecticut) |
| INVENTOR(S) | Zhong Shao (Branford, Connecticut); Ronghui Gu (New Haven, Connecticut); Vilhelm Sjoberg (New Haven, Connecticut); Jieung Kim (New Haven, Connecticut); Jeremie Koenig (New Haven, Connecticut) |
| ABSTRACT | Systems and methods for formal verification of programs. The systems and methods provide a new game-theoretical, strategy-based compositional semantic model for concurrency, a set of formal linking theorems for composing multithreaded and multicore concurrent layers, and a compiler that supports certified thread-safe compilation and linking. Verification of an overlay interface can include determining an intermediate strategy for a primitive operation running on an underlay interface and refining that intermediate strategy to a strategy running on the overlay interface by applying a vertical and a horizontal composition rule. The refined strategy can then be composed with compatible strategies running on the overlay interface according to a parallel composition rule. Strategies may be compatible when rely conditions imposed by each strategy satisfy guarantees provided by the other strategies. The system and method of formal verification can be applied to formal verification of smart contracts. |
| FILED | Tuesday, July 12, 2022 |
| APPL NO | 17/862480 |
| CURRENT CPC | Electric Digital Data Processing G06F 11/3608 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220366268 | Thompson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Aerospace Corporation (El Segundo, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Timothy Guy Thompson (Purcellville, Virginia); Ronald Scott Clifton (Leesburg, Virginia) |
| ABSTRACT | Systems and methods are provided for performing multi-objective optimizations with a relatively large number of objectives to which optimization is to be performed. The objectives of the optimization problem may be partitioned to two or more subsets (e.g., overlapping or non-overlapping subsets) of objectives, and partial optimization(s) may be performed using a subset or combination of subsets of the objectives. One or more of the partial optimizations may use one or more pareto-optimized chromosomes from a prior partial optimization. A final full optimization may be performed according to all of the objectives of the optimization problem and may use one or more chromosomes of any preceding partial optimization as a starting point for finding a final solution to the optimization problem. Any variety of processes may be employed to mitigate archive explosion that may be associated with relatively large objective sets. |
| FILED | Thursday, May 26, 2022 |
| APPL NO | 17/804253 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/126 (20130101) Original (OR) Class Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220366598 | AZIMI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Ehsan AZIMI (Baltimore, Maryland); Long QIAN (Baltimore, Maryland); Peter KAZANZIDES (Lutherville, Maryland); Nassir NAVAB (Fairfax, Virginia) |
| ABSTRACT | A calibration platform may obtain measurements for aligning a real-world coordinate system and a display coordinate system. For example, the calibration platform may display, via an optical see-through head-mounted display (OST-HMD), a three-dimensional virtual object and receive, from a positional tracking device, information that relates to a current pose of a three-dimensional real-world object to be aligned with the three-dimensional virtual object. The calibration platform may record a three-dimensional position of a plurality of points on the three-dimensional real-world object based on the current pose of the three-dimensional real-world object, based on an indication that the plurality of points on the three-dimensional real-world object respectively corresponds with a plurality of points on the three-dimensional virtual object. Accordingly, based on the obtained measurements, the calibration platform may generate a transformation function to provide a mapping between three-dimensional points in the real-world coordinate system and three-dimensional points in the display coordinate system. |
| FILED | Friday, July 08, 2022 |
| APPL NO | 17/811349 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/33 (20170101) G06T 7/73 (20170101) Original (OR) Class G06T 7/246 (20170101) G06T 19/006 (20130101) G06T 2207/30204 (20130101) Arrangements or Circuits for Control of Indicating Devices Using Static Means to Present Variable Information G09G 3/003 (20130101) G09G 2320/0693 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220366955 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Binbin Wang (Columbus, Ohio); David McComb (Columbus, Ohio) |
| ABSTRACT | Aspects herein are directed to nucleating skyrmions in spintronic materials by dynamic manipulation of an in-plane magnetic field and related design of prototype devices for spintronic memory and processing. Different from conventional phase transition methods, nucleating and manipulating skyrmion using in-plane fields and spin current pulses is described. For example, in a material with rotatable anisotropy and asymmetry geometric confinement, a skyrmion can be nucleated by switching the in-plane fields. This has been experimentally confirmed in a centrosymmetric magnet, Fe3Sn2, with an engineered thickness gradient. |
| FILED | Monday, March 14, 2022 |
| APPL NO | 17/693551 |
| CURRENT CPC | Static Stores G11C 11/18 (20130101) G11C 11/161 (20130101) G11C 11/1675 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220367695 | SMITH, Jr. et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CREE, INC. (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas J. SMITH, Jr. (Raleigh, North Carolina); Saptharishi SRIRAM (Cary, North Carolina) |
| ABSTRACT | An apparatus for reducing lag includes a substrate; a group III-Nitride barrier layer; a source electrically coupled to the group III-Nitride barrier layer; a gate on the group III-Nitride barrier layer; a drain electrically coupled to the group III-Nitride barrier layer; a p-region being arranged at or below the group III-Nitride barrier layer; and a gate control circuit configured to control a gate voltage of the gate. Additionally, at least a portion of the p-region is arranged vertically below at least one of the following: the source, the gate, and an area between the gate and the drain. |
| FILED | Monday, May 17, 2021 |
| APPL NO | 17/321963 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/205 (20130101) H01L 29/402 (20130101) H01L 29/2003 (20130101) H01L 29/7786 (20130101) Original (OR) Class H01L 29/66462 (20130101) Pulse Technique H03K 17/687 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220367798 | Hennighausen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Zachariah B. Hennighausen (Mount Rainier, Maryland); Kathleen M. McCreary (Washington, District of Columbia); Olaf M.J. van 't Erve (Falls Church, Virginia); Berend T. Jonker (Davidsnville, Maryland) |
| ABSTRACT | A method of laser-writing submicron pixels with tunable circular polarization and write-read-erase-reuse capability on Bi2Se3/WS2 at room temperature, comprising the steps of applying a laser to the Bi2Se3/WS2, writing a submicron pixel, wherein the submicron pixel has a circular polarization, modifying the circular polarization, allowing the circular polarization to be tuned across a range of 39.9%, tuning photoluminescence intensity, and tuning photoluminescence peak position. A method of growing Bi2Se3/WS2 as a nano-material or two-dimensional heterostructure for laser-writing submicron pixels with tunable circular polarization and write-read-erase-reuse capability on the Bi2Se3/WS2 heterostructure at room temperature. |
| FILED | Wednesday, March 09, 2022 |
| APPL NO | 17/690263 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) B82Y 20/00 (20130101) B82Y 40/00 (20130101) Static Stores G11C 7/005 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 45/143 (20130101) H01L 45/145 (20130101) H01L 45/1213 (20130101) Original (OR) Class H01L 45/1286 (20130101) H01L 45/1616 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220367843 | Eskra et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Eskra Technical Products, Inc. (Saukville, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael David Eskra (Saukville, Wisconsin); Paula Margaret Ralston (Frederick, Maryland); Rodney Mortensen LaFollette (South Jordan, Utah); James Bernard Nowakowski (Washburn, Wisconsin) |
| ABSTRACT | A solventless system for fabricating electrodes includes a mechanism for feeding a substrate through the system, a first application region comprised of a first device for applying a first layer to the substrate, wherein the first layer is comprised of an active material mixture and a binder, and the binder includes at least one of a thermoplastic material and a thermoset material, and the system includes a first heater positioned to heat the first layer. |
| FILED | Monday, July 11, 2022 |
| APPL NO | 17/811632 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/0404 (20130101) Original (OR) Class H01M 4/0419 (20130101) H01M 4/622 (20130101) H01M 4/623 (20130101) H01M 4/625 (20130101) H01M 4/1391 (20130101) H01M 4/1393 (20130101) H01M 4/1395 (20130101) H01M 10/0565 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220367884 | Gallant et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Betar Gallant (Cambridge, Massachusetts); Timothy Manning Swager (Newton, Massachusetts); Kosuke Yoshinaga (Cambridge, Massachusetts); Haining Gao (Cambridge, Massachusetts) |
| ABSTRACT | Systems, articles, and methods directed to electrochemical systems (e.g., batteries) and the electrochemical reduction of halogenated compounds are generally described. In certain embodiments, the halogenated compound comprises a haloalkane associated with a conjugated system via at least one alkene linker or alkyne linker. |
| FILED | Wednesday, February 23, 2022 |
| APPL NO | 17/679014 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/381 (20130101) H01M 4/382 (20130101) H01M 4/5835 (20130101) H01M 6/168 (20130101) Original (OR) Class H01M 10/0567 (20130101) H01M 2300/0025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220367885 | Gallant et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Betar Gallant (Cambridge, Massachusetts); Haining Gao (Cambridge, Massachusetts) |
| ABSTRACT | Systems, articles, and methods directed to electrochemical systems (e.g., batteries) and the electrochemical reduction of halogenated compounds are generally described. In certain embodiments, the halogenated compound comprises at least one sulfur pentahalide (e.g., pentafluoride) group associated with a conjugated system. |
| FILED | Wednesday, February 23, 2022 |
| APPL NO | 17/679031 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/133 (20130101) H01M 4/134 (20130101) H01M 6/168 (20130101) Original (OR) Class H01M 10/0567 (20130101) H01M 2004/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220367914 | Buttry et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| INVENTOR(S) | Daniel Buttry (Tempe, Arizona); Joseph Rheinhardt (Phoenix, Arizona) |
| ABSTRACT | Disclosed is a calcium salt, Ca(HMDS)2, where HMDS is the hexamethyldisilazide anion (also known as bis(trimethylsilyl)amide), enables high current densities and high coulombic efficiency for calcium metal deposition and dissolution. These properties facilitate the use of this salt in batteries based on calcium metal. In addition, the salt is significant for batteries based on metal anodes, which have higher specific energies than batteries based on intercalation anodes, such as LiC6. In particular, a calcium based rechargeable battery includes Ca(HMDS)2 salt and at least one solvent, the solvent suitable for calcium battery cycling. The at least one solvent can be diethyl ether, diisopropylether, methyl t-butyl ether (MTBE), 1,3-dioxane, 1,4-dioxane, tetrahydrofuran (THF), tetrahydropyran, glyme, diglyme, triglyme or tetraglyme, or any mixture thereof. |
| FILED | Friday, April 08, 2022 |
| APPL NO | 17/716226 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/44 (20130101) H01M 10/0565 (20130101) H01M 10/0568 (20130101) Original (OR) Class H01M 10/0569 (20130101) H01M 2300/0025 (20130101) H01M 2300/0085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220367974 | Eskra et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Eskra Technical Products, Inc. (Saukville, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael David Eskra (Saukville, Wisconsin); Paula Margaret Ralston (Frederick, Maryland) |
| ABSTRACT | A system and method for providing a ceramic-based separator onto an electrode is disclosed. A separator is formed on the electrode via a dry, solvent-free application of a ceramic-based separator to the electrode. An electrode is provided to an application area via a feed mechanism and a separator layer is then applied to the electrode that is comprised of a binder including at least one of a thermoplastic material and a thermoset material and an electrically non-conductive separator material, with the separator layer being applied to the electrode via a dry dispersion application. |
| FILED | Monday, July 11, 2022 |
| APPL NO | 17/811634 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/052 (20130101) H01M 50/46 (20210101) Original (OR) Class H01M 50/403 (20210101) H01M 50/446 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220367981 | McCoy |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CAMX Power LLC (Lexington, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher H. McCoy (Sherborn, Massachusetts) |
| ABSTRACT | Provided is a battery cell assembly that continues to operate near normal parameters following a fault in a cell. The battery cell assembly includes a plurality of repeating cell units. Each of the cell units is connected in parallel with another cell unit. Additionally, each of the cell units is connected in series with another cell unit. Each of the cell units includes n cells connected in series, the n cells having a voltage range tolerance of z % greater than a nominal operational voltage range. The n cells comprise a first end cell, a second end cell, and n−2 middle cells interposed between the first end cell and the second end cell. The middle cells are absent a parallel connection. In each of the cell units, n≥3 and z(n−1)≥100. Also provided is a method of compensating for a voltage loss from a shorted cell. |
| FILED | Monday, March 14, 2022 |
| APPL NO | 17/693669 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/485 (20130101) H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 10/0525 (20130101) H01M 50/51 (20210101) H01M 50/512 (20210101) Original (OR) Class H01M 2004/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220367998 | Page et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael R Page (Powell, Ohio); Piyush J Shah (West Chester, Ohio); Derek A Bas (Dayton, Ohio) |
| ABSTRACT | A nonreciprocal microwave transmission device includes a substrate, a transducer on a surface of the substrate and configured to reciprocally convert between electrical signals to acoustic waves, a first piezoelectric material configured to generates and transports acoustic waves from a signal applied to the transducer, and a thin film magnetic material configured to couple to acoustic waves through magnetoelastic coupling so as to have non-reciprocal magnetoelastic coupled acoustic wave transport. Transmission of acoustic waves through the thin film magnetic material is in a direction toward the transducer has a first magnitude and transmission of acoustic waves through the thin film magnetic material in a direction away from the transducer has a second magnitude, the first and second magnitude being significantly different. |
| FILED | Monday, April 11, 2022 |
| APPL NO | 17/717264 |
| CURRENT CPC | Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 1/32 (20130101) Original (OR) Class Impedance Networks, e.g Resonant Circuits; Resonators H03H 9/25 (20130101) H03H 9/145 (20130101) H03H 9/02559 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220368028 | Govoni et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | U.S. Army DEVCOM Army Research Laboratory (Aldelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark A. Govoni (Abingdon, Maryland); Seth A. McCormick (Arlington, Virginia) |
| ABSTRACT | A stacked patch antenna array includes: a conductive ground plane configured to connect to a plurality of electrical transmission lines for transmitting and/or receiving electrical signals; a driven layer adjacent to the conductive ground plane formed of a dielectric material and comprising a plurality of first resonant circular patches, each electrically connecting to a respective electrical transmission line such that a received electrical signal excites and generates an electromagnetic signal and/or a received electromagnetic signal excites and generates an electrical signal; an electrically insulating spacer adjacent to the driven layer; and a coupled layer adjacent to the electrically insulating spacer formed of a dielectric material and comprising a plurality of second resonant circular patches which are symmetrically positioned with respect to the first circular resonant patches of the driven layer and excited by the electromagnetic waves generated by the first resonant circular patches, wherein the electrically insulating spacer electrically separates the driven layer and the coupled layer having a thickness such that the resonances of the first and second resonant circular patches constructively combine. |
| FILED | Monday, May 17, 2021 |
| APPL NO | 17/322317 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 1/38 (20130101) H01Q 1/422 (20130101) H01Q 9/0414 (20130101) H01Q 21/065 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220368109 | ZHU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CLEMSON UNIVERSITY (CLEMSON, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | LIN ZHU (CLEMSON, South Carolina); XIAOLEI ZHAO (CLEMSON, South Carolina); YEYU ZHU (CLEMSON, South Carolina); SIWEI ZENG (CLEMSON, South Carolina) |
| ABSTRACT | To achieve high-power single transverse mode laser, we here propose a supersymmetry (SUSY)-based triple-ridge waveguide semiconductor laser structure, which is composed of an electrically pumped main broad-ridge waveguide located in the middle and a pair of lossy auxiliary partner waveguides. The auxiliary partner waveguides are designed to provide dissipative modes that can phase match and couple with the higher-order modes in the main waveguide. By appropriately manipulating the gain-loss discrimination of the modes in the laser cavity, one can effectively suppress all the undesired higher-order transverse modes while keeping the fundamental one almost unaffected, thereby ensuring stable single-mode operation with a larger emitting aperture and accordingly a higher output power than a conventional single-transverse-mode ridge waveguide diode laser. |
| FILED | Monday, May 02, 2022 |
| APPL NO | 17/734894 |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/22 (20130101) Original (OR) Class H01S 5/0655 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220368777 | Mulligan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Flashback Technologies, Inc. (Boulder, Colorado); The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Isobel Jane Mulligan (Niwot, Colorado); Gregory Zlatko Grudic (Niwot, Colorado); Steven L. Moulton (Littleton, Colorado) |
| ABSTRACT | Novel tools and techniques for assessing, predicting and/or estimating effectiveness of fluid resuscitation of a patient and/or an amount of fluid needed for effective resuscitation of the patient, in some cases, noninvasively. |
| FILED | Tuesday, July 26, 2022 |
| APPL NO | 17/873691 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/289 (20190101) Transmission of Digital Information, e.g Telegraphic Communication H04L 67/01 (20220501) H04L 67/10 (20130101) H04L 67/1008 (20130101) H04L 67/5683 (20220501) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220369465 | Petelik et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas Petelik (Alexandria, Virginia); Steven Bode (Alexandria, Virginia); Matthew Anderson (Hanover, Maryland) |
| ABSTRACT | An apparatus for interfacing with an RF/microwave subsystem is provided. The apparatus includes a printed circuit board that includes: a controller, and a connector constructed to provide control signals and power signals to a subsystem in accordance with instructions from the controller, and a mechanical interface constructed to provide a mechanical connection between the subsystem and the printed circuit board. |
| FILED | Tuesday, August 02, 2022 |
| APPL NO | 17/879484 |
| CURRENT CPC | Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors H01R 12/716 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/181 (20130101) Original (OR) Class H05K 2201/10189 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220369470 | Yuen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan D. Yuen (Washington, District of Columbia); Joyce C. Breger (Greenbelt, Maryland); David A. Stenger (Annapolis, Maryland) |
| ABSTRACT | Described herein are ultra-thin nanocellulose flexible electronic device on which SU-8, an epoxy material which can become highly stressed upon UV exposure, is printed on desired areas. Upon UV exposure and then release from the surface it is anchored on, the nanocellulose device will spontaneously self-mold into a desired form due to stress differences between the SU-8 and the nanocellulose sheet. The flexible electronics can be manufactured using standard printed circuit board processing techniques, including electroless metallization and soldering of surface mount components. |
| FILED | Friday, May 06, 2022 |
| APPL NO | 17/738122 |
| CURRENT CPC | Compositions of Macromolecular Compounds C08L 1/02 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/118 (20130101) H05K 1/0393 (20130101) H05K 3/125 (20130101) Original (OR) Class H05K 3/181 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20220361460 | Deng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Z. Daniel Deng (Richland, Washington); Jun Lu (Richland, Washington); Huidong Li (Richland, Washington); Jayson J. Martinez (Kennewick, Washington) |
| ABSTRACT | Organism monitoring systems and devices and associated monitoring methods are described. According to one aspect, an organism monitoring device configured to be associated with an organism to be monitored includes a housing, a battery coupled with the housing, wherein the battery is configured to store electrical energy, a transmitter coupled with the housing and the battery, wherein the transmitter is configured to emit a wireless signal externally of the organism monitoring device and the organism being monitored, sensor circuitry coupled with the housing and the battery, wherein the sensor circuitry is configured to monitor an environment of the organism monitoring device, and control circuitry coupled with the housing, the sensor circuitry and the battery, and wherein the control circuitry is configured to adjust an operation of the organism monitoring device as a result of monitoring of the environment of the organism monitoring device by the sensor circuitry. |
| FILED | Monday, May 17, 2021 |
| APPL NO | 17/322287 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 61/90 (20170101) Original (OR) Class Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 1/725 (20130101) Transmission Systems for Measured Values, Control or Similar Signals G08C 23/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362683 | Abbasi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Oregon State University (Corvallis, Oregon) |
| ASSIGNEE(S) | Oregon State University (Corvallis, Oregon) |
| INVENTOR(S) | Bahman Abbasi (Bend, Oregon); Xiang Zhang (Bend, Oregon); Mohammed Abbas Elhashimi Khalifa (Corvallis, Oregon); Deepak Sharma (Corvallis, Oregon) |
| ABSTRACT | This disclosure concerns a system and a method for removing dissolved solids from liquids. Specific implementations concern desalinating water. The system may comprise a blower, such as a thermal fan/compressor, configured to atomize a solid-bearing liquid to produce a hot, humid gas containing dissolved solids; a gas-solid separator configured to receive hot, humid gas containing entrained dissolved solids from the blower to separate the solids from the humid gas and to transmit the humid gas with solids removed through an exit port; a heater configured to heat the hot, humid gas received from the exit port of the gas-solid separator; and a condenser configured to receive heated humid gas from the heater and to condense solids-free liquid therefrom. The thermal fan/compressor may comprise a plurality of nozzles with outlets positioned adjacent atomization apertures across which a solid-bearing liquid flows and through which gas exiting the nozzles passes. |
| FILED | Wednesday, June 08, 2022 |
| APPL NO | 17/835137 |
| CURRENT CPC | Separation B01D 1/14 (20130101) B01D 1/16 (20130101) B01D 1/30 (20130101) Original (OR) Class B01D 1/0035 (20130101) B01D 5/006 (20130101) B01D 45/16 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/10 (20130101) C02F 1/14 (20130101) C02F 1/043 (20130101) C02F 2101/10 (20130101) Pumping of Fluid by Direct Contact of Another Fluid or by Using Inertia of Fluid to be Pumped; Siphons F04F 5/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362708 | Voskian et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Sahag Voskian (Cambridge, Massachusetts); Trevor Alan Hatton (Sudbury, Massachusetts) |
| ABSTRACT | The present disclosure generally relates to apparatuses, systems, and methods for separating a target species (e.g., CO2) from a gas mixture (e.g., gas stream) via an electrochemical process. |
| FILED | Monday, July 18, 2022 |
| APPL NO | 17/867454 |
| CURRENT CPC | Separation B01D 53/326 (20130101) Original (OR) Class B01D 2257/504 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362731 | Skoptsov et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | H QUEST VANGUARD, INC. (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George L. Skoptsov (Pittsburgh, Pennsylvania); Aayush Mantri (Pittsburgh, Pennsylvania); Vignesh Viswanathan (Pittsburgh, Pennsylvania); Preet K. Jain (Pittsburgh, Pennsylvania) |
| ABSTRACT | System and methods for plasma treatment of a fluidized bed of particles are disclosed. The systems include an energy coupling zone configured to generate a plasma from microwave radiation and an interface element configured to propagate the plasma from the energy coupling zone to a reaction zone. The reaction zone is configured to receive the plasma, receive a plurality of reactant particles in a fluidization plane direction from a fluidization assembly positioned below the reaction zone, and form a product in presence of the plasma. The fluidization plane is substantially perpendicular to the propagated plasma. |
| FILED | Tuesday, May 17, 2022 |
| APPL NO | 17/663821 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 8/388 (20130101) B01J 8/1836 (20130101) B01J 8/1872 (20130101) Original (OR) Class B01J 19/126 (20130101) B01J 2208/00442 (20130101) B01J 2208/00548 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362747 | Debusk et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Melanie M. Debusk (Oak Ridge, Tennessee); Sreshtha Sinha Majumdar (Oak Ridge, Tennessee); Josh A. Pihl (Oak Ridge, Tennessee) |
| ABSTRACT | A method of manufacturing a methane oxidation catalyst and methane oxidation catalysts formed by the method are provided. The method includes providing a palladium (Pd)-based catalyst including Pd dispersed onto a support. A magnesium (Mg) precursor is introduced to the Pd-based catalyst by one of ion exchange or incipient wetness impregnation. After introducing the magnesium precursor to the Pd-based catalyst, the catalyst is dried and subjected to a final heat treatment that includes hydrothermal calcination. A method of methane oxidation in a lean exhaust environment via the methane oxidation catalyst is also provided. |
| FILED | Monday, May 09, 2022 |
| APPL NO | 17/739263 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/10 (20130101) B01J 23/44 (20130101) Original (OR) Class B01J 29/7015 (20130101) B01J 35/04 (20130101) B01J 35/1014 (20130101) B01J 37/08 (20130101) B01J 37/0207 (20130101) Non-metallic Elements; Compounds Thereof; C01B 39/48 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2006/12 (20130101) C01P 2006/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362769 | Reiserer et al. |
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| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ronald S. Reiserer (Nashville, Tennessee); David K. Schaffer (Nashville, Tennessee); Philip C. Samson (Nashville, Tennessee); Dmitry A. Markov (Nashville, Tennessee); Michael Geuy (Nashville, Tennessee); Lisa J. McCawley (Nashville, Tennessee); John P. Wikswo (Brentwood, Tennessee) |
| ABSTRACT | Microfluidic systems, pumps, valves and applications of the same are provided. The microfluidic system may be a pump or a valve having a fluidic chip and an actuator controlling the opening and closing of the fluidic channel in the fluidic chip. The actuator may be disposed to tilt from the fluidic chip, forming a tilted-rotor peristaltic pump. Alternatively, the actuator may be a rolling ball actuator, and different fluidic chips may be used in different applications. For example, the fluidic chip may be a spiral pump chip having spiral channels, a rotary peristaltic pump chip having multiple output channels, or a multi-port valve chip having one port interconnected with multiple different ports. An analytical valve chip may switchably interconnect bioreactor and rinse/calibration input channels to sensor and waste output channels. The actuator of a random-access valve can move from one valve position to another without opening or closing intermediate ones. |
| FILED | Monday, June 29, 2020 |
| APPL NO | 17/623350 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502738 (20130101) Original (OR) Class B01L 2300/123 (20130101) B01L 2300/0627 (20130101) B01L 2400/0644 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362802 | Mahaffey et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jacob Thomas Mahaffey (Albuquerque, New Mexico); Kathryn N. Gabet Hoffmeister (Albuquerque, New Mexico); Andrew Vackel (Albuquerque, New Mexico); Wendy Flores-Brito (Pittsburgh, Pennsylvania); Deidre Hirschfeld (Tijeras, New Mexico) |
| ABSTRACT | Aerosol-deposited thermographic phosphors can be used for non-contact, two-dimensional temperature sensing in extreme environments. The fast response time and thermal/environmental stability of doped ceramic powders allow for temperature measurements up to the melting point of the phosphor on hot surfaces, such as rapidly rotating turbine components and combustors. |
| FILED | Thursday, May 26, 2022 |
| APPL NO | 17/825165 |
| CURRENT CPC | Spraying Apparatus; Atomising Apparatus; Nozzles B05B 7/1463 (20130101) Processes for Applying Fluent Materials to Surfaces, in General B05D 1/12 (20130101) Original (OR) Class Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/7701 (20130101) C09K 11/7707 (20130101) Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 11/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20220362829 — TOOLING ASSEMBLY AND METHOD FOR EXPLOSIVELY FORMING FEATURES IN A THIN-WALLED CYLINDER
| US 20220362829 | EBERL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SAVANNAH RIVER NUCLEAR SOLUTIONS, LLC (Aiken, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | KURT R. EBERL (AIKEN, South Carolina); WILLIAM M. HOUSLEY (AIKEN, South Carolina); JAMES M. SHULER (GERMANTOWN, Maryland); PAUL S. BLANTON (AIKEN, South Carolina); JOSHUA P. FLACH (AIKEN, South Carolina) |
| ABSTRACT | The present invention provides a method of explosively forming a helical tube from at least one thin-walled cylinder using a tooling assembly. The method includes inserting the at least one thin-walled cylinder into a die of the tooling assembly. The die surrounds the at least one thin-walled cylinder and includes an interior surface that defines a helical thread pattern. The method further includes surrounding the at least one thin-walled cylinder and the die with a casing of the tooling assembly. A cavity is defined by the casing and the thin-walled cylinder. The method further includes positioning an explosive charge within the cavity. The method additionally includes at least partially submerging the tooling assembly. The method further includes detonating the explosive charge. As a result, the at least one thin-walled cylinder is formed into a helical tube that corresponds with helical thread pattern of the interior surface of the die. |
| FILED | Friday, May 14, 2021 |
| APPL NO | 17/320523 |
| CURRENT CPC | Working or Processing of Sheet Metal or Metal Tubes, Rods or Profiles Without Essentially Removing Material; Punching Metal B21D 26/08 (20130101) Original (OR) Class B21D 51/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220363049 | Vernon |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| INVENTOR(S) | Gregory John Vernon (Kansas City, Missouri) |
| ABSTRACT | A system for creating an internal formation of a tubular structure having an inner surface via additive manufacturing. The system broadly includes a computer modeling system and an additive manufacturing system. The computer modeling system may include a processor for generating a lattice cellular component via computer-aided design software according to inputs received from a user. The processor may also generate an internal formation lattice structure based on the lattice cellular component and modify the lattice structure to follow and/or conform to the curvature of the inner surface of the outer wall of the tubular structure. The additive manufacturing system may be configured to produce the lattice structure and the tubular structure via additive manufacturing material deposited layer by layer according to the lattice structure. |
| FILED | Wednesday, July 27, 2022 |
| APPL NO | 17/874874 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/118 (20170801) B29C 64/386 (20170801) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2023/00 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220363238 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cummins Inc. (Columbus, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ke Li (Columbus, Indiana); Kenneth M. Follen (Greenwood, Indiana); Anant Puri (Columbus, Indiana); John P. Kresse, III (Columbus, Indiana); Apurva Arvind Chunodkar (Greenwood, Indiana) |
| ABSTRACT | Methods and systems for a powertrain power management in a vehicle with an electric motor, and an engine are disclosed. The methods and systems involve a powertrain that is operatively coupled to the engine and the electric motor, and an optimizer module operatively coupled to the powertrain. The optimizer module receives an operator information to travel a route from a remote management module, receives current route information for the route from a mapping application in response to the operator information, measures current vehicle status information for the hybrid vehicle, and decides a power management strategy for the vehicle based on the current route information and the current vehicle status information. |
| FILED | Wednesday, November 06, 2019 |
| APPL NO | 17/770598 |
| CURRENT CPC | Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 10/06 (20130101) B60W 10/08 (20130101) B60W 10/26 (20130101) B60W 20/15 (20160101) Original (OR) Class B60W 40/04 (20130101) B60W 40/076 (20130101) B60W 50/0205 (20130101) B60W 2510/242 (20130101) B60W 2552/15 (20200201) B60W 2555/20 (20200201) B60W 2555/60 (20200201) B60W 2556/10 (20200201) B60W 2556/50 (20200201) Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/3889 (20200801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220363552 | SHARMA |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jaswinder K. SHARMA (Oak Ridge, Tennessee) |
| ABSTRACT | A method for producing hollow silica particles, comprising: (i) producing a first batch of core-shell particles in which each core-shell particle contains a sacrificial core coated with a silica shell, by adding a tetrahydrocarbyl orthosilicate and hydroxide base to a suspension of sacrificial core particles in a solvent-water mixture, wherein the resulting suspension has a pH of at least 10, and wherein the foregoing steps result in a coating of silica on the sacrificial core particles to produce the first batch of core-shell particles; (ii) separating the first batch of core-shell particles from the solvent-water mixture; (iii) producing a second batch of core-shell particles in the first-stage recovered solvent-water; (iv) separating the second batch of core-shell particles from the first-stage recovered solvent-water mixture; and (v) subjecting the dry first and second batches of core-shell particles to a core removal process to produce the hollow silica particles. |
| FILED | Tuesday, June 23, 2020 |
| APPL NO | 17/621517 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 33/18 (20130101) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2004/34 (20130101) C01P 2004/61 (20130101) C01P 2004/62 (20130101) C01P 2004/64 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220363553 | Wiesner et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CORNELL UNIVERSITY (lthaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ulrich B. Wiesner (Ithaca, New York); Kai Ma (Belle Mead, New Jersey); Tangi Aubert (Gent, Belgium) |
| ABSTRACT | Porous compositions and methods of making and using same. The compositions may be one or more layer(s) of mesoporous inorganic materials. The mesoporous inorganic material(s) may be a plurality of inorganic nanocages, which may be microporous. A composition may include homostacks of layers of the same inorganic mesoporous materials. A composition may include heterostacks of layers of inorganic mesoporous materials, where at least two of the layers are different. The compositions may be surface functionalized. The compositions may be formed in a reaction mixture including one or more precursor(s), one or more surfactant(s), water, and one or more organic solvent(s). The compositions may be formed at the liquid-liquid interface between the water and the one or more organic solvent(s). A composition may be used as a catalyst, in a catalytic method, as a separation medium, in a separation method, in nanomedicine applications, or the like. |
| FILED | Monday, October 05, 2020 |
| APPL NO | 17/765766 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 33/18 (20130101) Original (OR) Class C01B 33/26 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/01 (20130101) C01P 2002/30 (20130101) C01P 2006/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220363784 | Leguizamon et al. |
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| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sanda, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Samuel Leguizamon (Albuquerque, New Mexico); Leah Appelhans (Tijeras, New Mexico) |
| ABSTRACT | Recent progress in photoinitiated ring-opening metathesis polymerization (photo-ROMP) has enabled the lithographic production of patterned films from olefinic resins. The use of a latent ruthenium catalyst (e.g., HeatMet) in combination with a photosensitizer (e.g., 2-isopropylthioxanthone) to rapidly photopolymerize metathesis-monomers (e.g., dicyclopentadiene (DCPD)) upon irradiation with UV light has previously been demonstrated. See U.S. application Ser. No. 17/677,558. In addition to the exemplary catalysts and photosensitizers described in that work, a variety of alternative catalysts and photosensitizers are commercially available that allows for tuning of thermomechanical properties, potlifes, activation rates, and irradiation wavelengths. As an example, fourteen catalysts and eight photosensitizers were surveyed for the photo-ROMP of DCPD and the structure-activity relationships of the catalysts examined. Properties relevant to photopolymerization-based additive manufacturing—potlifes, printing irradiation dose, conversion—were characterized to develop catalyst and photosensitizer libraries. Two optimized catalyst/photosensitizer systems were demonstrated in the rapid stereolithographic printing of complex, multidimensional pDCPD structures with microscale features under ambient conditions. |
| FILED | Thursday, June 02, 2022 |
| APPL NO | 17/830632 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 2/50 (20130101) Original (OR) Class C08F 4/80 (20130101) C08F 32/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220363904 | CHUNG et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| INVENTOR(S) | Tze-Chiang CHUNG (State College, Pennsylvania); Houxiang LI (University Park, Pennsylvania) |
| ABSTRACT | A new class of cost-effective carbon fiber precursors that comprise both hydrocarbon polymer and Pitch structural features in the same polymer structure to exhibit complementary advantages of both PAN- and Pitch-based carbon fiber precursors. The new class of carbon fiber precursors comprise a polymeric pitch copolymer, wherein the polymeric pitch copolymer includes a polymer chain and several pitch polycyclic aromatic hydrocarbon (PAH) molecules grafted or chemically bonded to the polymer chain. Method and processes for the creation of the new class of carbon fiber precursors are also presented, wherein said methods may comprise a thermally-induced coupling and extrusion step. |
| FILED | Tuesday, August 04, 2020 |
| APPL NO | 17/633465 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/05 (20170801) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 10/02 (20130101) C08F 38/02 (20130101) Compositions of Macromolecular Compounds C08L 95/00 (20130101) Original (OR) Class C08L 2203/12 (20130101) Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/06 (20130101) D01D 5/08 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 6/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220364189 | Tyagi |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of the District of Columbia (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pawan Tyagi (Derwood, Maryland) |
| ABSTRACT | A detection method and sensors are provided for the rapid detection of chemicals, biological and non-biological, and a wide range of viruses using magnetic tunnel junction-based molecular spintronics devices (MTJMSD) that produce unique magnetic resonance signals before and after interacting with target chemical, biochemical, viral, and other molecular agents. |
| FILED | Thursday, May 12, 2022 |
| APPL NO | 17/742775 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/70 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 10/3254 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220364254 | PALCZEWSKI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | JEFFERSON SCIENCE ASSOCIATES, LLC (NEWPORT NEWS, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ARI D. PALCZEWSKI (Westport, Connecticut); ERIC M. LECHNER (Newport News, Virginia); CHARLES E. REECE (Yorktown, Virginia) |
| ABSTRACT | A method for vacuum heat treating Nb, such as is used in superconducting radio frequency cavities, to engineer the interstitial oxygen profile with depth into the surface to conveniently optimize the low-temperature rf surface resistance of the material. An example application is heating of 1.3 GHz accelerating structures between 250-400° C. to achieve a very high quality factor of 5×1010 at 2.0 K. With data supplied by secondary ion mass spectrometry measurements, application of oxide decomposition and oxygen diffusion theory was applied to quantify previously unknown parameters crucial in achieving the oxygen alloy concentration profiles required to optimize the rf surface resistance. RF measurements of vacuum heat treated Nb superconducting radio frequency cavities confirmed the minimized surface resistance (higher Q0) previously expected only from 800° C. diffusive alloying with nitrogen. |
| FILED | Tuesday, May 03, 2022 |
| APPL NO | 17/735172 |
| CURRENT CPC | Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 11/26 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220364257 | PALCZEWSKI |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | JEFFERSON SCIENCE ASSOCIATES, LLC (NEWPORT NEWS, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ARI D. PALCZEWSKI (Westport, Connecticut) |
| ABSTRACT | An improved method of removing furnace contamination on niobium cavities to increase the quality factor (Q0) and the accelerating gradient (Eacc) of SRF accelerator cavities. Performing a nitric soak at or below 70% concentration removes contamination which can't be removed by conventional sulfuric/HF EP, HF soaking, which in turn can improve both Q0 and RF accelerating gradients in niobium. The chemical soak can also remove contamination from a niobium surface without removing the native oxide or bulk niobium removals, such as after infusion or mid-T baking. |
| FILED | Saturday, May 07, 2022 |
| APPL NO | 17/739097 |
| CURRENT CPC | Processes for the Electrolytic Removal of Materials From Objects; Apparatus Therefor C25F 3/26 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220364265 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Haiyan Wang (West Lafayette, Indiana); Robynn-Lynne Paldi (Albuquerque, New Mexico); Aleem Siddiqui (Albuquerque, New Mexico) |
| ABSTRACT | A method for making LNO film, including the steps of identifying a substrate, identifying a deposition target, placing the substrate and deposition target in a deposition environment, evolving target material into the deposition environment, and depositing evolved target material onto the substrate to yield an LNO film. The deposition environment defines a temperature of between 500 degrees Celsius and 750 degrees Celsius and a pressure of about 10−6 Torr. A seed or buffer layer may be first deposited onto the substrate, wherein the seed layer is about 30 mole percent gold and about 70 LiNbO3. |
| FILED | Monday, December 20, 2021 |
| APPL NO | 17/555660 |
| CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 25/06 (20130101) C30B 25/18 (20130101) C30B 29/30 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220364773 | Bahar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | FFI IONIX IP, INC. (Wilmington, Delaware) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bamdad Bahar (Georgetown, Delaware); William D. Parmelee (Seaford, Pennsylvania) |
| ABSTRACT | An electrochemical heat transfer device utilizes an electrochemical hydrogen compressor to pump hydrogen into and out of a reservoir having a metal hydride forming alloy therein. The absorption of hydrogen by the metal hydride forming alloy is exothermic, produces heat, and the desorption of the hydrogen from the metal hydride forming alloy is endothermic and draws heat in. An electrochemical hydrogen compressor may be configured between to reservoirs and pump hydrogen back and forth to form a heat transfer device. A heat exchange device may be coupled with the reservoir or may comprise the outer surface of the reservoir to transfer heat to an object or to the surroundings. A closed loop may be configured having two reservoirs and one or two electrochemical hydrogen compressors to pump the hydrogen in a loop around the system. |
| FILED | Monday, May 30, 2022 |
| APPL NO | 17/827923 |
| CURRENT CPC | Vessels for Containing or Storing Compressed, Liquefied or Solidified Gases; Fixed-capacity Gas-holders; Filling Vessels With, or Discharging From Vessels, Compressed, Liquefied, or Solidified Gases F17C 11/005 (20130101) Refrigeration Machines, Plants or Systems; Combined Heating and Refrigeration Systems; Heat-pump Systems F25B 17/12 (20130101) Original (OR) Class F25B 25/02 (20130101) F25B 35/04 (20130101) F25B 2500/18 (20130101) Technologies for Adaptation to Climate Change Y02A 30/27 (20180101) Climate Change Mitigation Technologies Related to Buildings, e.g Housing, House Appliances or Related End-user Applications Y02B 30/62 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220364919 | RINALDI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matteo RINALDI (Boston, Massachusetts); Vageeswar RAJARAM (Boston, Massachusetts); Zhenyun QIAN (Boston, Massachusetts); Sungho (Ryan) KANG (Cambridge, Massachusetts); Sila Deniz CALISGAN (Boston, Massachusetts); Antea RISSO (Cambridge, Massachusetts) |
| ABSTRACT | Ultra-low power methods and sensor devices are provided for determining the presence and magnitude of electromagnetic radiation or other signals. The sensor devices and methods provide both qualitative and quantitative analyses and can be deployed in remote locations for continuous monitoring over years without requiring a replacement power supply. |
| FILED | Tuesday, April 26, 2022 |
| APPL NO | 17/729214 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/42 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220365000 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Brookhaven Science Associates, LLC (Upton, New York); The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mingzhao Liu (Syosset, New York); Justine E. Haupt (Mattituck, New York); Connie-Rose Mai Deane (Moriches, New York); Oleg Gang (Setauket, New York) |
| ABSTRACT | An apparatus includes a main body, circuit assembly, lens, and clamping assembly. The main body includes an aperture that receives a wafer configured to receive a sample under study. The main body is configured to support the circuit assembly, which includes illumination sources that emit light of different colors such that total internal reflection is generated in the wafer. The main body is configured to provide support for the lens, and the clamping assembly mechanically coupled to the main body such that the lens is selectively positionable with respect to a camera lens. A microscopy imaging apparatus includes an illumination source, wafer, and charge-coupled device. The illumination source is configured to emit white light such that total internal reflection is generated in the wafer. The sample under study is disposed between the wafer and the charge coupled device, and the charge coupled device is configured to obtain an image of the sample under study upon illumination of the wafer by the illumination source. |
| FILED | Monday, May 16, 2022 |
| APPL NO | 17/745506 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/8806 (20130101) G01N 21/9501 (20130101) Original (OR) Class G01N 21/95684 (20130101) G01N 2021/8822 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220367073 | Callaway et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NuScale Power, LLC (Portland, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Allyson Callaway (Corvallis, Oregon); Ben Bristol (Philomath, Oregon); Kenneth Rooks (Corvallis, Oregon); Larry Linik (Corvallis, Oregon) |
| ABSTRACT | A nuclear power system includes a reactor vessel that includes a reactor core mounted, the reactor core including nuclear fuel assemblies configured to generate a nuclear fission reaction; a riser positioned above the reactor core; a primary coolant flow path that extends from a bottom portion of the volume below the reactor core, through the reactor core, within the riser, and through an annulus between the riser and the reactor vessel back to the bottom portion of the volume; a primary coolant that circulates through the primary coolant flow path to receive heat from the nuclear fission reaction and release the received heat to generate electric power in a power generation system fluidly or thermally coupled to the primary coolant flow path; and a control system communicably coupled to the power generation system and configured to control a power output of the nuclear fission reaction independent of any control rod assemblies during the normal operation. |
| FILED | Thursday, June 02, 2022 |
| APPL NO | 17/831083 |
| CURRENT CPC | Methods of Steam Generation; Steam Boilers F22B 35/004 (20130101) Nuclear Reactors G21C 7/22 (20130101) G21C 9/02 (20130101) Original (OR) Class G21C 9/022 (20130101) G21C 9/027 (20130101) G21C 9/033 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220367075 | Malloy, III et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BWXT mPower, Inc. (Charlotte, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John D. Malloy, III (Goode, Virginia); Billy E. Bingham (Lynchburg, Virginia); Ronald C. Watson (Forest, Virginia); Jason G. Williams (Concord, Virginia); Matthew W. Ales (Puyallup, Washington); James B. Inman (Forest, Virginia); Sean M. Boyle (Charlotte, North Carolina) |
| ABSTRACT | In a pressurized water reactor (PWR), emergency core cooling (ECC) responds to depressurization due to a vessel penetration break at the top of the pressure vessel by draining water from a body of water through an injection line into the pressure vessel. A barrier operates concurrently with the ECC to suppress flow of liquid water from the pressure vessel out the vessel penetration break. The barrier may comprise one or more of: (1) an injection line extension passing through the central riser to drain water into the central riser; (2) openings in a lower portion of a central riser to shunt some upward flow from the central riser into a lower portion of the downcomer annulus; and (3) a surge line providing fluid communication between a pressurizer volume at the top of the pressure vessel and the remainder of the pressure vessel which directs water outboard toward the downcomer annulus. |
| FILED | Thursday, June 02, 2022 |
| APPL NO | 17/831043 |
| CURRENT CPC | Nuclear Reactors G21C 1/09 (20130101) G21C 1/32 (20130101) G21C 1/322 (20130101) G21C 15/18 (20130101) Original (OR) Class G21C 15/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220367164 | Blain et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew G. Blain (Albuquerque, New Mexico); Christopher Nordquist (Albuquerque, New Mexico); Peter Lukas Wilhelm Maunz (Albuquerque, New Mexico) |
| ABSTRACT | In an ion trap chip, an RF electrode for producing a radio-frequency ion-trapping electric field is formed in one of a plurality of metallization layers formed on a substrate and separated from each other by intermetal dielectric. At least two spans of the RF electrode are suspended between support pillars over a void defined within one or more layers of intermetal dielectric. For each span that is suspended between a first and a second support pillar, an area ATotal and an area ASupported are defined. ATotal is the total electrode area from an initial edge of the first support pillar to an initial edge of the second support pillar. ASupported is the electrode area directly underlain by the first support pillar. In each span that is suspended from a first support pillar to a second support pillar, ASupported is not more than one-half of ATotal. |
| FILED | Thursday, July 21, 2022 |
| APPL NO | 17/870465 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Electric Discharge Tubes or Discharge Lamps H01J 3/40 (20130101) H01J 49/0018 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220367184 | Eom et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chang-Beom Eom (Madison, Wisconsin); Jungwoo Lee (Madison, Wisconsin) |
| ABSTRACT | Methods and systems for forming complex oxide films are provided. Also provided are complex oxide films and heterostructures made using the methods and electronic devices incorporating the complex oxide films and heterostructures. In the methods pulsed laser deposition is conducted in an atmosphere containing a metal-organic precursor to form highly stoichiometric complex oxides. |
| FILED | Monday, July 25, 2022 |
| APPL NO | 17/814565 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/28 (20130101) C23C 14/088 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/02414 (20130101) H01L 21/02565 (20130101) Original (OR) Class H01L 21/02631 (20130101) H01L 29/24 (20130101) H01L 29/778 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220367738 | Sewell et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SunPower Corporation (San Jose, California); Total Marketing Services (Puteaux, France) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard Hamilton Sewell (Los Altos, California); Robert Woehl (San Jose, California); Jens Dirk Moschner (Heverlee, Belgium); Nils-Peter Harder (San Jose, California) |
| ABSTRACT | Approaches for fabricating wire-based metallization for solar cells, and the resulting solar cells, are described. In an example, a solar cell includes a substrate having a back surface and an opposing light-receiving surface. A plurality of alternating N-type and P-type semiconductor regions is disposed in or above the back surface of the substrate. A conductive contact structure is disposed on the plurality of alternating N-type and P-type semiconductor regions. The conductive contact structure includes a plurality of metal wires. Each metal wire of the plurality of metal wires is parallel along a first direction to form a one-dimensional layout of a metallization layer for the solar cell. |
| FILED | Thursday, June 09, 2022 |
| APPL NO | 17/836822 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/0682 (20130101) H01L 31/022441 (20130101) Original (OR) Class Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/547 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220367739 | BUSH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin Alexander BUSH (Stanford, California); Axel F. PALMSTROM (Santa Barbara, California); Michael David MC GEHEE (Palo Alto, California); Stacey F. BENT (Stanford, California) |
| ABSTRACT | A perovskite-based solar cell comprising a transparent electrode disposed on a buffer layer that protects the perovskite from damage during the deposition of the electrode is disclosed. The buffer material is deposited using either low-temperature atomic-layer deposition, chemical-vapor deposition, or pulsed chemical-vapor deposition. In some embodiments, the perovskite material is operative as an absorption layer in a multi-cell solar-cell structure. In some embodiments, the perovskite material is operative as an absorption layer in a single-junction solar cell structure. |
| FILED | Thursday, March 24, 2022 |
| APPL NO | 17/703446 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/302 (20130101) H01L 31/03923 (20130101) H01L 31/03925 (20130101) H01L 31/022475 (20130101) Original (OR) Class H01L 31/022483 (20130101) H01L 51/442 (20130101) H01L 51/4273 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/549 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220367777 | REN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Houston System (Houston, Texas) |
| ASSIGNEE(S) | University of Houston System (Houston, Texas) |
| INVENTOR(S) | Zhifeng REN (Pearland, Texas); Hangtian ZHU (Houston, Texas) |
| ABSTRACT | A method of thermoelectric power generation by converting heat to electricity via the use of a ZrCoBi-based thermoelectric material, wherein a thermoelectric conversion efficiency of the ZrCoBi-based thermoelectric material is greater than or equal to 7% at a temperature difference of up to 800 K. |
| FILED | Thursday, June 09, 2022 |
| APPL NO | 17/836072 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 35/02 (20130101) H01L 35/18 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220367836 | QU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yue QU (Ann Arbor, Michigan); Xiaheng Huang (Ann Arbor, Michigan); Stephen R. Forrest (Ann Arbor, Michigan) |
| ABSTRACT | A method of fabricating a light emitting device comprises providing a mold having an unpolished surface with an arithmetic mean roughness Ra in a range from 0.1 μm to 10 μm, depositing a thin polymer film over the surface of the mold, wherein the film has a thickness in a range from 1 μm to 100 μm, positioning a light emitting body onto the thin polymer film, wherein the light emitting body includes an anode, a cathode, and a light emitting layer positioned between the anode and the cathode, and separating the thin polymer film with the light emitting body from the mold. A light emitting device is also described. |
| FILED | Friday, May 27, 2022 |
| APPL NO | 17/826722 |
| CURRENT CPC | Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2031/3475 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/003 (20130101) H01L 51/56 (20130101) H01L 51/0097 (20130101) H01L 51/5016 (20130101) H01L 51/5268 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220367895 | Strasser et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Giner, Inc. (Newton, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Derek J. Strasser (Marlborough, Massachusetts); Hui Xu (Acton, Massachusetts) |
| ABSTRACT | Membrane electrode assembly and method for fabricating the same. In one embodiment, the method may involve providing an anion exchange membrane and then applying catalyst coatings to opposing surfaces of the anion exchange membrane, whereby a membrane electrode assembly may be formed. Next, the membrane electrode assembly may be subjected to a two-part treatment process. In a first part of the process, the membrane electrode assembly may be swelled, at room temperature, by exposure to an aqueous ethanol solution vapor while being retained under tension in a frame. The aqueous ethanol solution vapor may be, for example, 80:20 by volume ethanol and water. In a second part of the process, the swollen membrane electrode assembly may be removed from the frame and then pressed, at room temperature, between two plates. A layer of rubber and a layer polytetrafluoroethylene may be placed between each plate and the swollen membrane electrolyte assembly. |
| FILED | Thursday, May 12, 2022 |
| APPL NO | 17/743303 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/1004 (20130101) Original (OR) Class H01M 8/1055 (20130101) H01M 2008/1095 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220367897 | BENICEWICZ et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF SOUTH CAROLINA (COLUMBIA, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | BRIAN C. BENICEWICZ (COLUMBIA, South Carolina); LAURA MURDOCK (COLUMBIA, South Carolina); LIHUI WANG (WEST COLUMBIA, South Carolina); FEI HUANG (WEST COLUMBIA, South Carolina); ANDREW PINGITORE (COLUMBIA, South Carolina) |
| ABSTRACT | Disclosed are redox flow battery membranes, redox flow batteries incorporating the membranes, and methods of forming the membranes. The membranes include a polybenzimidazole gel membrane that is capable of incorporating a high liquid content without loss of structure that is formed according to a process that includes in situ hydrolysis of a polyphosphoric acid solvent. The membranes are imbibed with a redox flow battery supporting electrolyte such as sulfuric acid and can operate at very high ionic conductivities of about 100 mS/cm or greater. Redox flow batteries incorporating the PBI-based membranes can operate at high current densities of about 100 mA/cm2 or greater. |
| FILED | Friday, March 04, 2022 |
| APPL NO | 17/686631 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/92 (20130101) H01M 4/8605 (20130101) H01M 4/8828 (20130101) H01M 8/1027 (20130101) Original (OR) Class H01M 8/1032 (20130101) H01M 8/1044 (20130101) H01M 8/1048 (20130101) H01M 8/1067 (20130101) H01M 8/1081 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220368020 | Byers et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| INVENTOR(S) | Kyle J. Byers (Kansas City, Missouri); Brian C. Rutherford (Stilwell, Kansas); Matt Clewell (Kansas City, Missouri) |
| ABSTRACT | An antenna system comprises a substrate, an antenna positioned on the substrate, and a circuit component positioned on the substrate. The antenna is positioned on a first surface of the substrate and operable to emit a radiation pattern. The circuit component is positioned on the substrate in a null region of the radiation pattern. The thickness of portions of the substrate are modified to achieve a desired performance characteristic of the antenna. |
| FILED | Friday, July 15, 2022 |
| APPL NO | 17/865685 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 1/2283 (20130101) H01Q 11/083 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220368249 | Moheimani et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Seyed Omid Reza Moheimani (Allen, Texas); Afshin Alipour (Richardson, Texas); Mustafa Bulut Coskun (Pasadena, California) |
| ABSTRACT | A microelectromechanical (MEMS) device is provided. The MEMS device comprises a substrate and a movable structure flexurally connected to the substrate, capable of moving in relation to the substrate, wherein the movable structure further comprising two or more segments having at least one mechanical connection between said segments to provide structural integrity of the moving structure; and wherein the at least one mechanical connection electrically isolates at least two segments |
| FILED | Monday, December 20, 2021 |
| APPL NO | 17/645229 |
| CURRENT CPC | Scanning-probe Techniques or Apparatus; Applications of Scanning-probe Techniques, e.g Scanning Probe Microscopy [SPM] G01Q 60/16 (20130101) Electric Machines Not Otherwise Provided for H02N 1/006 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20220361802 | Voitiuk et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kateryna Voitiuk (Santa Cruz, California); Jinghui Geng (Santa Cruz, California); Robert Currie (Santa Cruz, California); Mircea Teodorescu (Santa Cruz, California) |
| ABSTRACT | An electrophysiological monitoring system includes an electrophysiology amplifier chip configured to couple to a plurality of electrophysiological electrodes and to measure electrophysiological signals. The system also includes a computing device configured to receive and to process the electrophysiological signals. The system further includes an interface device coupled to the electrophysiological amplifier chip and the computing device, the interface device configured to convert communication signals between the computing device and the electrophysiology amplifier chip. |
| FILED | Friday, May 13, 2022 |
| APPL NO | 17/743842 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/384 (20210101) Original (OR) Class A61B 5/386 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220361917 | MEENAKSHISUNDARAM |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania) |
| INVENTOR(S) | RAVI SHANKAR MEENAKSHISUNDARAM (ASPINWALL, Pennsylvania) |
| ABSTRACT | An optically transparent actuator apparatus is provided that includes an optically transparent bi-stable member including an optically transparent liquid crystalline polymer layer. The bi-stable member is structured to move from a first state to a second state in response to a first stimulus and from the second state to the first state in response to a second stimulus. Also, a display apparatus includes a plate member and an actuator assembly coupled to the plate member. The actuator assembly includes a number of optically transparent liquid crystalline polymer layers, wherein each of the optically transparent liquid crystalline polymer layers is structured to move from a first state to a second state in response to a first stimulus. |
| FILED | Monday, July 11, 2022 |
| APPL NO | 17/811619 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/00154 (20130101) A61B 17/32 (20130101) A61B 17/34 (20130101) A61B 17/3423 (20130101) A61B 17/3476 (20130101) Original (OR) Class A61B 18/00 (20130101) A61B 18/08 (20130101) A61B 18/12 (20130101) A61B 18/1487 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 19/38 (20130101) C09K 19/0208 (20130101) Electric Digital Data Processing G06F 3/016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362159 | COLLIER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joel COLLIER (Durham, North Carolina); Sean KELLY (Durham, North Carolina) |
| ABSTRACT | The present disclosure provides, in part, peptide self-assemblies that are made into tablet form and methods of making and using the same. In some embodiments, the disclosure provides methods and formulations for a tabletized form of a vaccine, particularly a vaccine comprising self-assembling peptide-polymer nanofibers, an excipient and an adjuvant. Methods of making and using the tablet formulation are also provided. |
| FILED | Monday, September 28, 2020 |
| APPL NO | 17/764406 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0056 (20130101) A61K 9/2018 (20130101) A61K 9/2095 (20130101) Original (OR) Class A61K 47/60 (20170801) A61K 47/6929 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362334 | MATALON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE UAB RESEARCH FOUNDATION (Birmingham, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sadis MATALON (Birmingham, Alabama); Saurabh AGGARWALL (Birmingham, Alabama); Tamas JILLING (Birmingham, Alabama); Rakesh PATEL (Birmingham, Alabama) |
| ABSTRACT | Hemopexin, salubrinal, aurothioglucose, and nitrite find uses in treating pulmonary injury from several causes, alone and in combination. Methods of treatment, methods of prevention, and pharmaceutical compositions are provided with those components. |
| FILED | Friday, September 04, 2020 |
| APPL NO | 17/640534 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7135 (20130101) A61K 33/00 (20130101) A61K 38/1709 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362733 | STEFIK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTH CAROLINA (Columbia, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | MORGAN STEFIK (COLUMBIA, South Carolina); TAYLOR LARISON (CAYCE, South Carolina) |
| ABSTRACT | A method of forming persistent micelles is described. Particularly, methods disclosed herein include dissolving a block copolymer in a first solvent to form a dispersion containing unimers or dynamic micelles. Further, a method includes contacting the dispersion with a second solvent forming the persistent micelles. The persistent micelles formed by the method of the present disclosure can be used for controlled delivery of dispersions in organic electronic coatings, paint, or drug delivery applications and can also be used to control the pore size of films that include an oxide, a nitride, a carbide, a metal, or a carbon material. |
| FILED | Thursday, March 17, 2022 |
| APPL NO | 17/697148 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/185 (20130101) Original (OR) Class Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 220/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362767 | Kashkin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Fabrico Technology, Inc. (Georgetown, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alex Kashkin (Cambridge, Massachusetts); Joseph Oleniczak (Austin, Texas); Robert Chin (Austin, Texas) |
| ABSTRACT | A system includes a cartridge and an instrument. The cartridge includes a cartridge body defining an input port aligned with a central axis of the cartridge body, a plurality of channels in fluidic communication with the input port and extending radially to a plurality of reaction chamber connectors, a plurality of reaction chambers disposed at a radial distance from the central axis of the cartridge body and distributed at angles relative to the others of the plurality of reaction chambers. The system further includes an instrument including an incubation block configured to receive the plurality of reaction chambers; a motor and socket to connect with the cartridge; an illumination source having an illumination pathway; and a camera disposed in a signal pathway intersecting the illumination pathway. |
| FILED | Sunday, October 25, 2020 |
| APPL NO | 17/771771 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) Original (OR) Class B01L 2200/16 (20130101) B01L 2200/0684 (20130101) B01L 2300/0832 (20130101) Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/51 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362776 | Seitter et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cerillo, LLC (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin Seitter (Charlottesville, Virginia); Kristin Schmidt (Charlottesville, Virginia); Thomas Moutinho, Jr. (Charlottesville, Virginia) |
| ABSTRACT | The present invention generally relates to a solid-state, multi-well plate reader including an emitter assembly having a plurality of emitters and a receptor assembly having a plurality of receptors, where the positions of these assemblies are not fixed relative to each other but are temporarily aligned for measurement by way of two alignment trays. |
| FILED | Monday, October 18, 2021 |
| APPL NO | 17/451162 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 3/502784 (20130101) Original (OR) Class B01L 2200/10 (20130101) B01L 2200/12 (20130101) B01L 2300/041 (20130101) B01L 2300/0654 (20130101) B01L 2300/0819 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/3563 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220363415 | Conn |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Orbital AI LLC (Detroit, Michigan) |
| ASSIGNEE(S) | Orbital AI LLC (Detroit, Michigan) |
| INVENTOR(S) | Tracie Renea Conn (Grosse Pointe Woods, Michigan) |
| ABSTRACT | The present disclosure provides a method for controlling orbital trajectories of a plurality of spacecraft in a multi-spacecraft swarm. In one aspect, the method includes deploying a DRL agent including a plurality of trajectory control models to the multi-spacecraft swarm, the trajectory control models corresponding to swarm configurations of the multi-spacecraft swarm; determining a state vector of said plurality of spacecraft in the multi-spacecraft swarm; transmitting a collective command to the multi-spacecraft swarm, such that said plurality of spacecraft in the multi-spacecraft swarm are to be distributed in one of the swarm configurations; determining actions of said plurality of spacecraft based on the state vector and the collective command; and maneuvering the multi-spacecraft swarm in accordance with the actions. |
| FILED | Wednesday, May 12, 2021 |
| APPL NO | 17/318390 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/242 (20130101) Original (OR) Class B64G 2001/245 (20130101) B64G 2001/247 (20130101) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 13/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220363547 | Chien |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Wyoming (Laramie, Wyoming) |
| ASSIGNEE(S) | University of Wyoming (Laramie, Wyoming); University of Wyoming (Laramie, Wyoming) |
| INVENTOR(S) | TeYu Chien (Laramie, Wyoming) |
| ABSTRACT | A metal-assisted microwave treatment that converting raw coal powders into nano-graphite is presented. Specifically, four major factors are identified for successful conversion: (1) high temperature; (2) reducing environment; (3) catalyst; and (4) microwave radiation. Specifically, it is determined that the combination of the carbon sources (raw coal powders), the high temperature (microwave induced electric sparking), the reducing environment (the Ar/H2 mixture), the catalyst (Cu foil), with the microwave radiations can generate nano-graphite. This novel approach utilizes the sparking induced by the microwave radiation on the fork-shape metal foils to generate high temperature (>1000° C.) within few seconds. The small thermal load makes this method cost effective and has potential for higher temperature using metals with higher melting temperature. Refinement of this technique is possible to yield a higher quality and quantity of nano-graphite materials for a wider range of applications. |
| FILED | Monday, May 16, 2022 |
| APPL NO | 17/745643 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 6/008 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/205 (20170801) Original (OR) Class Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 3/02 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/82 (20130101) C01P 2004/03 (20130101) C01P 2004/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220363604 | Maria et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jon-Paul Maria (State College, Pennsylvania); Sarah Lowum (State College, Pennsylvania); Richard Floyd (State College, Pennsylvania) |
| ABSTRACT | Embodiments relate to an improved hydroflux assisted densification process that introduces a transport phase (formed by the introduction of water during the process to suppress melting temperatures) for sintering, the transport phase being a non-aqueous solution. The process can facilitate sintering at low temperature ranges (at or below 300° C.) to yield densification>90% without the need for additional post-processing steps that otherwise would be needed if conventional processes were used. Control of the pressures and water content used during the process can enhance densification mechanisms related to dissolution-reprecipitation, allowing for a greater range of compositional spectra of materials that can be densified, a reduction of the amount of transport phase needed, a reduction of impurities and an improvement of properties in the densified material. Certain hydrated acetate powders can be used to generate a hydroxide mixture flux that is better for the low-temperature densification process. |
| FILED | Thursday, October 01, 2020 |
| APPL NO | 17/765469 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/016 (20130101) C04B 35/45 (20130101) C04B 35/64 (20130101) C04B 35/453 (20130101) C04B 35/495 (20130101) C04B 35/653 (20130101) C04B 35/2658 (20130101) C04B 35/6303 (20130101) Original (OR) Class C04B 35/6325 (20130101) C04B 2235/48 (20130101) C04B 2235/604 (20130101) C04B 2235/3201 (20130101) C04B 2235/3255 (20130101) C04B 2235/3258 (20130101) C04B 2235/3262 (20130101) C04B 2235/3274 (20130101) C04B 2235/3281 (20130101) C04B 2235/3284 (20130101) C04B 2235/3298 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220363612 | WACHSMAN et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric D. WACHSMAN (Fulton, Maryland); Dongxia LIU (Clarksville, Maryland); Mann SAKBODIN (Bangkok, Thailand) |
| ABSTRACT | In a first stage of a methane conversion system, at least some methane (CH4) in an input gas flow stream can be converted into C2 hydrocarbons, hydrogen gas (H2), and aromatics to provide a first processed stream. The conversion can be direct non-oxidative methane conversion (DNMC). At least some of the aromatics can be removed from the first processed stream to provide a second processed stream. In a second stage of the methane conversion system, at least some of the H2 can be removed from the second processed stream to provide a recycle stream. The recycle stream can be returned to the first stage of the methane conversion system for further conversion of methane and removal of aromatics and H2 products. |
| FILED | Tuesday, May 17, 2022 |
| APPL NO | 17/746229 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 10/00 (20130101) B01J 19/0053 (20130101) B01J 19/1893 (20130101) B01J 21/08 (20130101) B01J 23/745 (20130101) Acyclic or Carbocyclic Compounds C07C 2/84 (20130101) Original (OR) Class C07C 2521/08 (20130101) C07C 2523/745 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220363931 | Das et al. |
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| FUNDED BY |
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| APPLICANT(S) | Kansas State University Research Foundation (Manhattan, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Suprem R. Das (Manhattan, Kansas); Wenjun Xiang (Manhattan, Kansas); Anand P.S. Gaur (Manhattan, Kansas) |
| ABSTRACT | Electrically conductive ink compositions are provided that comprise at carbon nanomaterials of one-dimensional, two-dimensional, and quasi-three-dimensional nanostructures and/or their combinations, and/or doping with elements such as nitrogen, boron, sulfur, in certain ratios. The carbon nanomaterials are selected from the group consisting of graphene and graphene oxide particles, carbon nanotubes, and graphene aerosol gels. |
| FILED | Thursday, June 25, 2020 |
| APPL NO | 17/621762 |
| CURRENT CPC | Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/36 (20130101) C09D 11/38 (20130101) C09D 11/52 (20130101) Original (OR) Class Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 4/252 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220364047 | He et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaoming He (Bethesda, Maryland); Jiangsheng Xu (Greenbelt, Maryland); James Shamul (Lanham, Maryland) |
| ABSTRACT | Disclosed are microcapsule compositions and methods for encapsulating living cells. The methods include a microencapsulation approach to isolate and culture high-quality stem cells, including human iPSCs, cancer stem cells, cardiac stem cells, and the like. The microencapsulation methods are inspired by the development of blastomeres into a blastocyst within the Zona pellucida of the human female reproductive system. The bioinspired methods include encapsulation of blastomere-like cell clusters in a Zona-like microcapsule including a miniaturized hyaluronic acid-rich core and a semipermeable hydrogel shell. The cell clusters are subsequently cultured to form highly pluripotent spheroids with improved cell quality, homogeneity, and viability. Methods of use of said microcapsules are also disclosed including therapeutic uses related to human iPSC-based personalized medicines. |
| FILED | Friday, May 13, 2022 |
| APPL NO | 17/663372 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0012 (20130101) Original (OR) Class C12N 5/0657 (20130101) C12N 5/0695 (20130101) C12N 5/0696 (20130101) C12N 2506/45 (20130101) C12N 2533/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20220364100 — OLIGONUCLEOTIDE COMPOUNDS FOR TREATMENT OF PREECLAMPSIA AND OTHER ANGIOGENIC DISORDERS
| US 20220364100 | Khvorova et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts); BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anastasia Khvorova (Westborough, Massachusetts); Melissa Moore (Chestnut Hill, Massachusetts); Anton A. Turanov (Boston, Massachusetts); Ananth Karumanchi (Chestnut Hill, Massachusetts) |
| ABSTRACT | This disclosure relates to novel targets for angiogenic disorders. Novel oligonucleotides are also provided. Methods of using the novel oligonucleotides for the treatment of angiogenic disorders (e.g., preeclampsia) are also provided. |
| FILED | Tuesday, April 12, 2022 |
| APPL NO | 17/718918 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) C12N 15/1138 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/50 (20130101) C12N 2310/315 (20130101) C12N 2310/321 (20130101) C12N 2310/322 (20130101) C12N 2310/344 (20130101) C12N 2310/346 (20130101) C12N 2310/351 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220364189 | Tyagi |
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| FUNDED BY |
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| APPLICANT(S) | University of the District of Columbia (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pawan Tyagi (Derwood, Maryland) |
| ABSTRACT | A detection method and sensors are provided for the rapid detection of chemicals, biological and non-biological, and a wide range of viruses using magnetic tunnel junction-based molecular spintronics devices (MTJMSD) that produce unique magnetic resonance signals before and after interacting with target chemical, biochemical, viral, and other molecular agents. |
| FILED | Thursday, May 12, 2022 |
| APPL NO | 17/742775 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/70 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 10/3254 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220365034 | NEOGI et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of North Texas (Dallas, Texas); ECHONOVUS INC. (Denton, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arup NEOGI (Dallas, Texas); Ezekiel WALKER (Denton, Texas); Jin YUQI (Dallas, Texas); Tae-Youl CHOI (Dallas, Texas); Arkadii KROKHIN (Dallas, Texas) |
| ABSTRACT | A method of non-destructive evaluation of mechanical properties of a material using ultrasonic waves in a monostatic configuration is disclosed. The method comprises remotely scanning a sample of the material without directly contacting the sample, measuring an acoustic impedance of the scanned sample, and calculating mechanical properties of the material using the acoustic impedance. |
| FILED | Friday, May 22, 2020 |
| APPL NO | 17/612193 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/587 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/07 (20130101) G01N 29/09 (20130101) Original (OR) Class G01N 29/28 (20130101) G01N 29/043 (20130101) G01N 29/0645 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220365044 | JONES et al. |
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| FUNDED BY |
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| APPLICANT(S) | Activated Research Company, LLC (Eden Prairie, Minnesota) |
| ASSIGNEE(S) | Activated Research Company, LLC (Eden Prairie, Minnesota) |
| INVENTOR(S) | Andrew JONES (Minneapolis, Minnesota); Tommy Saunders (St. Louis Park, Minnesota); Mike Hofflander (Edina, Minnesota) |
| ABSTRACT | In the present system and method, a conduit from a LC device continuously transports solvent, buffers, and analytes to the inlet of a solvent removal and analyte conversion device which evaporates the solvents, leaving non-volatile analytes for detection. The device comprises a rotating disk. The liquid chromatograph device can be any device using liquid chromatography to separate molecules. The solvents in the LC effluent can include, but are not limited to, water, methanol, acetonitrile, tetrahydrofuran, and acetone. After removal of the volatile components, the non-volatile analytes are converted with a concentrated energy source so that they may be detectable. |
| FILED | Wednesday, July 20, 2022 |
| APPL NO | 17/869244 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/38 (20130101) G01N 30/64 (20130101) Original (OR) Class G01N 2030/347 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220365065 | Nouri et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Reza Nouri (State College, Pennsylvania); Yuqian Jiang (State College, Pennsylvania); Xiaojun Lance Lian (State College, Pennsylvania); Weihua Guan (State College, Pennsylvania) |
| ABSTRACT | Methods of detecting a target nucleic acid sequence analyte are provided in which a crRNA and Cas12 or Cas13 enzyme are contacted to form a non-activated RNP. The non-activated RNP is contacted with a sample containing or suspected of containing the target nucleic acid sequence, and the target nucleic acid sequence and non-activated RNP specifically bind to each other if the target nucleic acid is present in the sample, thereby forming an activated RNP. A reporter nucleic acid is contacted with the activated RNP, and the activated RNP indiscriminately cleaves the reporter nucleic acid, reducing passage of intact, non-cleaved reporter nucleic acid through a nanopore in of a nanopore counting device such that a reduction of resistive pulses is produced which provides a signal representative of presence of the target nucleic acid sequence in the sample. |
| FILED | Friday, July 17, 2020 |
| APPL NO | 17/627372 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6825 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/48721 (20130101) Original (OR) Class G01N 2333/922 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220365148 | MOLDWIN et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark B. MOLDWIN (Ann Arbor, Michigan); Lauro V. OJEDA (Ann Arbor, Michigan) |
| ABSTRACT | A magneto-inductive DC magnetometer is provided that is operable to output fluxgate quality measurements in a low mass, volume, power and cost package. The magnetometer enables constellation-class missions not only due to its low-resource requirements, but also due to its potential for commercial integrated circuit fabrication. In addition, the magnetometer will be part of a ground-based Space Weather Underground Citizen Science instrument package that enables dense arrays of space weather-relevant observations at mid-latitudes. The magneto-inductive operating principle is based on a simple resistance-inductor (RL) circuit and involves measurement of the time it takes to charge and discharge the inductor between an upper and lower threshold by means of a Schmitt trigger oscillator. This time is proportional to the inductance that in turn is proportional to the field strength. |
| FILED | Wednesday, May 11, 2022 |
| APPL NO | 17/741723 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/24 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/0206 (20130101) Original (OR) Class Meteorology G01W 1/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220365243 | Makin, III et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF WESTERN MICHIGAN UNIVERSITY (Kalamazoo, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Allen Makin, III (Kalamazoo, Michigan); Steven Michael Durbin (Kalamazoo, Michigan) |
| ABSTRACT | A method for quantifying disorder and extracting a corresponding numerical value of an order parameter from contrast analysis applied to optical images acquired of the solar photosphere. Temporal variation of the order parameter may be utilized to predict events such as solar flares, which have the ability to disrupt both communication systems and satellite orbits. The degree of order of the photosphere may be monitored to predict solar flares and other solar events. The method may utilize a spin-based (Ising/Potts) model of disorder. |
| FILED | Tuesday, May 03, 2022 |
| APPL NO | 17/735729 |
| CURRENT CPC | Meteorology G01W 1/10 (20130101) Original (OR) Class Image or Video Recognition or Understanding G06V 10/25 (20220101) G06V 10/507 (20220101) G06V 20/46 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220365429 | Meyers et al. |
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| FUNDED BY |
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| APPLICANT(S) | Inrpia Corporation (Corvallis, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen T. Meyers (Corvallis, Oregon); Douglas A. Keszler (Corvallis, Oregon); Kai Jiang (Corvallis, Oregon); Jeremy T. Anderson (Corvallis, Oregon); Andrew Grenville (Corvallis, Oregon) |
| ABSTRACT | Organometallic solutions have been found to provide high resolution radiation based patterning using thin coatings. The patterning can involve irradiation of the coated surface with a selected pattern and developing the pattern with a developing agent to form the developed image. The patternable coatings may be susceptible to positive-tone patterning or negative-tone patterning based on the use of an organic developing agent or an aqueous acid or base developing agent. The radiation sensitive coatings can comprise a metal oxo/hydroxo network with organic ligands. A precursor solution can comprise an organic liquid and metal polynuclear oxo-hydroxo cations with organic ligands having metal carbon bonds and/or metal carboxylate bonds. |
| FILED | Thursday, June 02, 2022 |
| APPL NO | 17/830535 |
| CURRENT CPC | Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/09 (20130101) G03F 7/20 (20130101) G03F 7/30 (20130101) G03F 7/32 (20130101) G03F 7/0042 (20130101) Original (OR) Class G03F 7/0043 (20130101) G03F 7/322 (20130101) G03F 7/325 (20130101) G03F 7/2002 (20130101) G03F 7/2037 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220365512 | HAN et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sang Eon HAN (Albuquerque, New Mexico); Sang M. HAN (Albuquerque, New Mexico); Bokyung PARK (Albuquerque, New Mexico); Bryan KAEHR (Albuquerque, New Mexico); Andrew P. SHREVE (Albuquerque, New Mexico) |
| ABSTRACT | A method for developing an evolved structure by artificial evolution includes: obtaining one or more properties of a biological structure; computationally evolve the biological structure to obtain an evolved descriptor; inverse-mapping the evolved description to real space to form an evolved structure design; and constructing the evolved structure. The evolved structure comprises stronger performance across the properties than the biological structure. In an example aspect, a method for constructing an evolved structure includes: removing sericin from a cocoon; forming a first solution from the cocoon with removed sericin; forming a silk fibroin powder from the first solution; dissolving the silk fibroin powder to form a second solution; and electro spinning the second solution based on the evolved structure design. |
| FILED | Friday, October 23, 2020 |
| APPL NO | 17/771382 |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/4099 (20130101) Original (OR) Class G05B 2219/49023 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220365862 | Shao et al. |
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| FUNDED BY |
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| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | Yale University (New Haven, Connecticut) |
| INVENTOR(S) | Zhong Shao (Branford, Connecticut); Ronghui Gu (New Haven, Connecticut); Vilhelm Sjoberg (New Haven, Connecticut); Jieung Kim (New Haven, Connecticut); Jeremie Koenig (New Haven, Connecticut) |
| ABSTRACT | Systems and methods for formal verification of programs. The systems and methods provide a new game-theoretical, strategy-based compositional semantic model for concurrency, a set of formal linking theorems for composing multithreaded and multicore concurrent layers, and a compiler that supports certified thread-safe compilation and linking. Verification of an overlay interface can include determining an intermediate strategy for a primitive operation running on an underlay interface and refining that intermediate strategy to a strategy running on the overlay interface by applying a vertical and a horizontal composition rule. The refined strategy can then be composed with compatible strategies running on the overlay interface according to a parallel composition rule. Strategies may be compatible when rely conditions imposed by each strategy satisfy guarantees provided by the other strategies. The system and method of formal verification can be applied to formal verification of smart contracts. |
| FILED | Tuesday, July 12, 2022 |
| APPL NO | 17/862480 |
| CURRENT CPC | Electric Digital Data Processing G06F 11/3608 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220366009 | SHAH et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Devavrat D. SHAH (Waban, Massachusetts); Anish AGARWAL (Newton, Massachusetts); Muhammad AMJAD (Cambridge, Massachusetts); Dennis SHEN (Irvine, California) |
| ABSTRACT | A system and method model a time series from missing data by imputing missing values, denoising measured but noisy values, and forecasting future values of a single time series. A time series of potentially noisy, partially-measured values of a physical process is represented as a non-overlapping matrix. For several classes of common model functions, it can be proved that the resulting matrix has a low rank or approximately low rank, allowing a matrix estimation technique, for example singular value thresholding, to be efficiently applied. Applying such a technique produces a mean matrix that estimates latent values, of the physical process at times or intervals corresponding to measurements, with less error than previously known methods. These latent values have been denoised (if noisy) and imputed (if missing). Linear regression of the estimated latent values permits forecasting with an error that decreases as more measurements are made. |
| FILED | Thursday, July 07, 2022 |
| APPL NO | 17/811112 |
| CURRENT CPC | Measuring Not Specially Adapted for a Specific Variable; Arrangements for Measuring Two or More Variables Not Covered in a Single Other Subclass; Tariff Metering Apparatus; Measuring or Testing Not Otherwise Provided for G01D 1/14 (20130101) Electric Digital Data Processing G06F 17/16 (20130101) Original (OR) Class G06F 17/18 (20130101) Computer Systems Based on Specific Computational Models G06N 7/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220366223 | Fathallah-Shaykh et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE UAB RESEARCH FOUNDATION (Birmingham, Alabama); ROWAN UNIVERSITY (Glassboro, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hassan Fathallah-Shaykh (Vestavia Hills, Alabama); Nidhal Bouaynaya (Voorhees, New Jersey); Ghulam Rasool (Mickleton, New Jersey); Dimah Dera (Glassboro, New Jersey) |
| ABSTRACT | Disclosed are various approaches for estimating uncertainty in deep neural networks. A respective tensor normal distribution can be applied to each of a plurality of convolutional kernels of a convolutional neural network, wherein the respective tensor normal distribution captures a correlation and a variance heterogeneity of each of the plurality of convolutional kernels. Then, the mean and covariance of each respective tensor normal distribution passing through the non-linear activation function of each nonlinear perceptron can be approximated. Next, a max-pool operation can be performed on a plurality of outputs of the plurality of non-linear perceptrons to generate an output tensor. Then, the output tensor can be vectorized to create an input vector for a fully-connected layer of the convolutional neural network. Subsequently, an output vector can be generated using the fully-connected layer. Then, a mean matrix and a covariance matrix for the output vector can be computed. |
| FILED | Wednesday, September 30, 2020 |
| APPL NO | 17/764133 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/0481 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220366709 | Robles et al. |
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| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Francisco E. Robles (Atlanta, Georgia); Ashkan Ojaghi (Atlanta, Georgia) |
| ABSTRACT | A deep-ultraviolet microscopy system includes a light source for outputting a light beam for illuminating a biological sample, the light beam being inclusive of ultraviolet wavelengths; a reception space for reception of a biological sample for illumination by the light beam; an ultraviolet microscope objective for collecting and relaying light that interacts with the biological sample to an image capture device; and an ultraviolet sensitive image capture device for capturing images of the biological sample, with the microscopy system configured to capture multiple images of the biological sample at one or more ultraviolet wavelengths. A method of processing ultraviolet images of biological samples includes receiving a plurality of multi-spectral ultraviolet images of a biological sample; normalizing and scaling the images; and assigning each image to a channel in the RGB color-space based on wavelength. |
| FILED | Tuesday, October 13, 2020 |
| APPL NO | 17/767328 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/33 (20130101) G01N 33/49 (20130101) G01N 2201/0621 (20130101) Optical Elements, Systems, or Apparatus G02B 21/16 (20130101) G02B 21/365 (20130101) Image Data Processing or Generation, in General G06T 3/40 (20130101) Image or Video Recognition or Understanding G06V 10/70 (20220101) G06V 20/693 (20220101) G06V 20/695 (20220101) G06V 20/698 (20220101) Original (OR) Class Pictorial Communication, e.g Television H04N 5/2256 (20130101) H04N 9/64 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220366803 | Tunik et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University Center for Research Innovation, Northeastern Univ. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eugene Tunik (Windham, New Hampshire); Mathew Yarossi (Medford, Massachusetts); Samuel Berin (Boston, Massachusetts) |
| ABSTRACT | Computer-implemented methods and systems are disclosed for designing and conducting virtual reality experiments. The method includes the steps of: (a) providing a configuration user interface through a computer system enabling a user to design a virtual reality experiment by integrating one or more peripheral sensors in an immersive virtual environment; (b) running the virtual reality experiment configured in step (a) and collecting experiment data from the one or more peripheral sensors; and (c) outputting the experiment data. |
| FILED | Monday, May 16, 2022 |
| APPL NO | 17/745272 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/011 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 5/02 (20130101) Original (OR) Class G09B 19/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220367090 | Pixley et al. |
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| FUNDED BY |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | Jedediah Pixley (Highland Park, New Jersey); Nicodemos Varnava (Highland Park, New Jersey); David Vanderbilt (Princeton, New Jersey); Justin Wilson (Highland Park, New Jersey) |
| ABSTRACT | Various embodiments include an electrical device comprising an antiferromagnetic topological insulator having a surface comprising a bulk domain wall configured to support a first type of 1D chiral channel, a surface step configured to support a second 1D chiral channel and intersecting the bulk domain wall to form thereat a quantum point junction. |
| FILED | Wednesday, March 09, 2022 |
| APPL NO | 17/690627 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/072 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/212 (20210101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 1/0072 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 43/04 (20130101) H01L 43/06 (20130101) H01L 43/10 (20130101) H01L 43/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220367141 | CAMERON et al. |
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| FUNDED BY |
|
| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Duncan CAMERON (Ithaca, New York); Jared MAXSON (Ithaca, New York); David MULLER (Ithaca, New York) |
| ABSTRACT | The present invention relates to a monochromator device. The monochromator device includes a first radiofrequency cavity positioned to receive an output beam from an electron source. A second radiofrequency cavity is positioned to receive the output beam from the first radiofrequency cavity. The first radiofrequency cavity and the second radiofrequency cavity are configured to, in combination, in combination, correct one or more energy deviations in time and space of the output beam. |
| FILED | Thursday, September 03, 2020 |
| APPL NO | 17/639903 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 37/26 (20130101) H01J 37/141 (20130101) H01J 37/147 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220367865 | XIONG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BOISE STATE UNIVERSITY (Boise, Idaho) |
| ASSIGNEE(S) | Boise State University (Boise, Idaho); The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | HUI XIONG (Boise, Idaho); Pete Barnes (Boise, Idaho); SHYE PING ONG (Menlo Park, California); YUNXING ZUO (San Diego, California) |
| ABSTRACT | Systems and methods are disclosed for a rock-salt structure formed from an electrochemically-driven amorphous-to-crystalline (a-to-c) transformation of nanostructured Nb2O5, the rock-salt structure including, upon cycling with lithium ions (Li+), an insertion of lithium ions (Li+) into Nb2O5 to form the rock-salt structure (RS—Nb2O5). |
| FILED | Monday, May 16, 2022 |
| APPL NO | 17/663487 |
| CURRENT CPC | Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 33/00 (20130101) Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 11/26 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/485 (20130101) Original (OR) Class H01M 10/0525 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220367884 | Gallant et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Betar Gallant (Cambridge, Massachusetts); Timothy Manning Swager (Newton, Massachusetts); Kosuke Yoshinaga (Cambridge, Massachusetts); Haining Gao (Cambridge, Massachusetts) |
| ABSTRACT | Systems, articles, and methods directed to electrochemical systems (e.g., batteries) and the electrochemical reduction of halogenated compounds are generally described. In certain embodiments, the halogenated compound comprises a haloalkane associated with a conjugated system via at least one alkene linker or alkyne linker. |
| FILED | Wednesday, February 23, 2022 |
| APPL NO | 17/679014 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/381 (20130101) H01M 4/382 (20130101) H01M 4/5835 (20130101) H01M 6/168 (20130101) Original (OR) Class H01M 10/0567 (20130101) H01M 2300/0025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220368514 | Fei et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yunsi Fei (Needham, Massachusetts); Zhen Jiang (Tampa, Florida) |
| ABSTRACT | Embodiments protect against memory-based side-channel attacks by efficiently shuffling data. In an example implementation, in response to a data access request by an encryption methodology regarding a first data element from amongst a plurality of data elements stored in memory, a storage address of a second data element of the plurality is determined. This storage address is determined using (i) an address of the first data element in the memory, (ii) a permutation function, and (iii) a random number. In turn, the first data element is stored at the determined storage address of the second data element and the second data element is stored at the address of the first data element. In this way, embodiments protect encryption methodologies from memory-based side-channel attacks. |
| FILED | Tuesday, April 19, 2022 |
| APPL NO | 17/723711 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/005 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220368777 | Mulligan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Flashback Technologies, Inc. (Boulder, Colorado); The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Isobel Jane Mulligan (Niwot, Colorado); Gregory Zlatko Grudic (Niwot, Colorado); Steven L. Moulton (Littleton, Colorado) |
| ABSTRACT | Novel tools and techniques for assessing, predicting and/or estimating effectiveness of fluid resuscitation of a patient and/or an amount of fluid needed for effective resuscitation of the patient, in some cases, noninvasively. |
| FILED | Tuesday, July 26, 2022 |
| APPL NO | 17/873691 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/289 (20190101) Transmission of Digital Information, e.g Telegraphic Communication H04L 67/01 (20220501) H04L 67/10 (20130101) H04L 67/1008 (20130101) H04L 67/5683 (20220501) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20220361461 | Mirsaeidi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mehdi Mirsaeidi (Miami, Florida); Chongxu Zhang (Miami, Florida) |
| ABSTRACT | The disclosure relates to a sarcoidosis animal model and methods of inducing sarcoidosis in an animal. The disclosure also relates to methods of producing an in vitro granuloma, and methods of using the sarcoidosis animal model. Disclosed herein are animals comprising one or more granulomas, wherein the one or more granulomas comprise Mycobacterium abscessus cell wall microparticles. |
| FILED | Friday, June 26, 2020 |
| APPL NO | 17/623382 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/02 (20130101) Original (OR) Class A01K 2207/10 (20130101) A01K 2227/105 (20130101) A01K 2267/0331 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362407 | Mahajan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); The United States Govemment as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vinit Mahajan (Palo Alto, California); Katherine J. Wert (Dallas, Texas) |
| ABSTRACT | A construct comprising a promoter specific for non-pigmented ciliary epithelial cells (NPCECs) is provided. In particular, the construct comprises a BEST2 minimal promoter that confers NPCEC-specific expression. The BEST2 minimal promoter may be operably linked to an expressible sequence such as a gene encoding a polypeptide of interest, a regulatory RNA sequence, a reporter gene, and the like. Such constructs may be provided in an expression vector, for example, with the BEST2 minimal promoter operably linked to an expressible sequence or in a host cell genetically modified with such an expression vector. |
| FILED | Thursday, September 24, 2020 |
| APPL NO | 17/762591 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) A61K 38/465 (20130101) A61K 48/0058 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0621 (20130101) C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/86 (20130101) C12N 2310/20 (20170501) C12N 2740/15043 (20130101) C12N 2740/15045 (20130101) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220363722 | Pahan |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rush University Medical Center (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kalipada Pahan (Skokie, Illinois) |
| ABSTRACT | Compositions for inhibiting the binding between ACE2 and SARS-CoV-2 spike S1 are disclosed. Methods of treating COVID-19 are disclosed. Methods of making an in vivo model of COVID-19 are also disclosed. |
| FILED | Monday, March 21, 2022 |
| APPL NO | 17/699792 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/162 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/005 (20130101) Original (OR) Class C07K 2319/10 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2770/20022 (20130101) C12N 2770/20033 (20130101) C12N 2770/20071 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220364142 | Mahajan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia); UNIVERSITY OF IOWA RESEARCH FOUNDATION (IOWA CITY, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vinit Mahajan (Redwood City, California); Gabriel Velez (Palo Alto, California); Young Joo Sun (Redwood City, California); Kellie A Schaefer (Redwood City, California); Alexander G Bassuk (Iowa City, Iowa) |
| ABSTRACT | Compositions, methods, and kits are provided for assaying calpain-5 activity and inhibition. In particular, novel peptide substrates are provided for detecting calpain-5, measuring calpain-5 activity, and screening for inhibitors of calpain-5 to identify potential therapeutic agents for treating retinal diseases and other diseases associated with calpain-5 hyperactivity. Additionally, novel inhibitors of calpain-5 are also provided. |
| FILED | Friday, October 09, 2020 |
| APPL NO | 17/767280 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) A61K 49/0008 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/37 (20130101) Original (OR) Class Enzymes C12Y 304/22 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2333/96466 (20130101) G01N 2500/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20220363865 | Markvicka et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric Markvicka (Lincoln, Nebraska); Ethan Krings (Lincoln, Nebraska) |
| ABSTRACT | A lightweight liquid metal composition and a method for producing a lightweight liquid metal composition. The composition includes: a liquid metal inclusion; a low-density phase including a plurality of particles; and an elastic polymer. The method includes: combining a low-density phase with a liquid metal to produce a multiphase liquid metal (LM), the low-density phase including a material having a density less than a density of the LM; mixing the multiphase LM with an elastomer to produce an emulsion; and curing the emulsion to produce a lightweight LM composition. |
| FILED | Friday, February 25, 2022 |
| APPL NO | 17/681541 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/314 (20170801) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2083/00 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 40/10 (20200101) B33Y 70/10 (20200101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 77/04 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/08 (20130101) Original (OR) Class C08K 7/26 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/023 (20130101) C09D 11/037 (20130101) C09D 11/102 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220364512 | Underwood et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rolls-Royce North American Technologies Inc. (Indianapolis, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David S. Underwood (San Jose, California); Geoffrey O. Campbell (Broomfield, Colorado) |
| ABSTRACT | Fuel injectors having a fuel-air heat exchange system and methods thereof for use in a gas turbine engine. The fuel-air heat exchanger allows heat transfer between a flow of cooling air used to cool components of the engine and a flow of fuel used to drive the engine to transfer heat to the flow of fuel and cool the cooling air. |
| FILED | Tuesday, May 11, 2021 |
| APPL NO | 17/317415 |
| CURRENT CPC | Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/224 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2240/35 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220365233 | First et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Phillip Neal First (Atlanta, Georgia); Zhigang Jiang (Atlanta, Georgia); Thomas Michael Orlando (Atlanta, Georgia); Elliot Christian Frey (Atlanta, Georgia) |
| ABSTRACT | A radiation detector (100) includes an insulating substrate (110), which includes a material that undergoes a change in an electrical property when subjected to ionizing radiation. A conductive film (112) is disposed in relation to a surface of the substrate. The conductive film (112) has a resistance that is a function of a state of the electrical property. A resistance measuring device measures resistance across the conductive film (112). The resistance measured by the resistance measuring device indicates an amount of ionizing radiation to which the substrate (110) has been subjected. In a method of determining exposure to a type of radiation, a boron nitride substrate is exposed to a radiation environment. A resistance is measured across a conductive film disposed in relation to the boron nitride substrate. Radiation exposure is calculated as a function of the resistance. |
| FILED | Friday, July 10, 2020 |
| APPL NO | 17/625206 |
| CURRENT CPC | Measurement of Nuclear or X-radiation G01T 1/26 (20130101) Original (OR) Class G01T 3/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220366798 | Dill et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Evan T. Dill (Poquoson, Virginia); Kyle M. Smalling (Newport News, Virginia); Steven D. Young (Poquoson, Virginia); Cuong C. Quach (Hampton, Virginia); Kelly J. Hayhurst (Seaford, Virginia); Anthony J. Narkawicz (Yorktown, Virginia); Russell V. Gilabert (Lewis Center, Ohio) |
| ABSTRACT | A geo-containment system includes at least one unmanned vehicle and an enforcement system that is onboard the unmanned vehicle and configured to limit travel of the unmanned vehicle based, at least in part, on predefined geospatial operational boundaries. Such boundaries may include a primary boundary and at least one secondary boundary that is spaced apart from the primary boundary a minimum safe distance. The minimum safe distance is determined while the unmanned vehicle is traveling. The minimum safe distance is determined using state information of the unmanned vehicle and/or dynamics of the unmanned vehicle. The state information includes at least position and velocity of the unmanned vehicle. The enforcement system is configured to alter and/or terminate operation of the unmanned vehicle if the unmanned vehicle violates the primary geospatial operational boundary and/or the secondary geospatial boundary. The enforcement system may inter-relate with the unmanned vehicle through an onboard vehicle control system. |
| FILED | Friday, July 15, 2022 |
| APPL NO | 17/865980 |
| CURRENT CPC | Traffic Control Systems G08G 5/006 (20130101) G08G 5/0069 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20220362810 | Bombaugh |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott R. Bombaugh (Burke, Virginia) |
| ABSTRACT | Embodiments of a system and method for sorting and sequencing articles in a processing facility are disclosed. Delivery endpoints are divided and grouped into stop groups. A first sorter sorts items according to stop group and outputs the items to trays. The output trays from the first sorter are loaded to a second sorter in stop group order. The second sorter sorts items for each stop group into separate lanes. Each lane can then be sorted into output bins in delivery sequence order. |
| FILED | Friday, May 27, 2022 |
| APPL NO | 17/804444 |
| CURRENT CPC | Postal Sorting; Sorting Individual Articles, or Bulk Material Fit to be Sorted Piece-meal, e.g by Picking B07C 1/025 (20130101) B07C 3/02 (20130101) Original (OR) Class B07C 3/08 (20130101) B07C 3/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220366163 | Simpson |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan J. Simpson (Vienna, Virginia) |
| ABSTRACT | The present disclosure relates to a system for reading a barcode independently of image resolution or scale of a captured barcode image. In one embodiment, the system includes an optical sensor and a processor. The optical scanner can scan a barcode, including a plurality of bars and spaces, into a scanned image. The processor can convert the scanned image into binary data. The processor can also calculate numbers of ones (1s) between zeros (0s) in the binary data and determine widths of one of i) each of the bars and ii) each of the spaces based on the calculated numbers of ones (1s). The processor can further calculate numbers of zeros (0s) between ones (1s) in the binary data and determine widths of the other one of i) each of the bars and ii) each of the spaces based on the calculated numbers of zeros (0s). |
| FILED | Wednesday, July 27, 2022 |
| APPL NO | 17/815533 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 7/1413 (20130101) G06K 7/10722 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220366367 | Dearing |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen M. Dearing (Herndon, Virginia) |
| ABSTRACT | A system and method for accurately sort items for delivery and track the delivery of items in an item distribution network using a purpose built confidence event recorder. Items can then be tracked while out for delivery through the use of confidence data recorded by a confidence event recorder carried by an item carrier. Confidence data can be used to accurately record when and where item carriers deliver items and can be used for generating and transmitting an expected delivery window. |
| FILED | Thursday, July 28, 2022 |
| APPL NO | 17/815813 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 7/1413 (20130101) G06K 7/10861 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/0833 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220368778 | Worner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Roger Worner (Saint Peters, Missouri); Jason Alan Tamayo (St. Augustine, Florida) |
| ABSTRACT | A content management system for customizing and controlling data distribution is disclosed. Data items can be customized and dispersed to disparate reception terminals according to various control mechanisms where they can convey relevant information to local or remote stakeholders. Data items can be integrated into existing data distribution structures in real time according to applicable control mechanisms and distribution protocols. Data resources can be efficiently used in distributing data under predefined and configurable conditions. Control mechanisms and distribution protocols can be determined based on an interested user's recognized status within the system. Design of the distribution system allows for informed delivery of essential information in a controlled and automated fashion such that users can interact with the system in receiving or distributing current and relevant information across the distribution network for others to access. |
| FILED | Monday, August 01, 2022 |
| APPL NO | 17/816588 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/1454 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Transmission of Digital Information, e.g Telegraphic Communication H04L 43/16 (20130101) H04L 67/10 (20130101) H04L 67/60 (20220501) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Environmental Protection Agency (EPA)
| US 20220362310 | O'Toole et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trustees of Dartmouth College (Hanover, New Hampshire); Dartmouth-Hitchcock Clinic (Lebanon, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George A. O'Toole (Hanover, New Hampshire); Juliette C. Madan (Lyme, New Hampshire) |
| ABSTRACT | The present disclosure relates to a method of altering intestinal microbiome in a patient having cystic fibrosis comprising administering at least one of Bifidobacterium and/or Bacteroides to a patient and allowing the Bifidobacterium and/or Bacteroides to alter the intestinal microbiome. |
| FILED | Thursday, May 19, 2022 |
| APPL NO | 17/664156 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/741 (20130101) A61K 35/744 (20130101) A61K 35/745 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) A61P 11/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362763 | Cromwell et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Protein Fluidics, Inc. (Burlingame, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Evan Francis Cromwell (Redwood City, California); Wilson Toy (San Francisco, California); Liran Yosef Haller (Berkeley, California); Ori Hoxha (San Francisco, California); Braxton Dunstone (San Francisco, California); Hong Jiao (Santa Clara, California) |
| ABSTRACT | Provided are valveless microfluidic flowchips comprising fluid flow barrier structures or configurations. Further provided are systems and methods having increased fluid transfer control in a valveless microfluidic flowchip. The systems and methods can be used in the present valveless microfluidic flowchips as well as in currently available valveless microfluidic flowchips. |
| FILED | Monday, May 23, 2022 |
| APPL NO | 17/664594 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/567 (20130101) B01L 3/50273 (20130101) Original (OR) Class B01L 3/502746 (20130101) B01L 3/502753 (20130101) B01L 3/502761 (20130101) B01L 2200/027 (20130101) B01L 2200/0647 (20130101) B01L 2200/0684 (20130101) B01L 2300/14 (20130101) B01L 2300/048 (20130101) B01L 2300/165 (20130101) B01L 2300/0636 (20130101) B01L 2300/0883 (20130101) B01L 2400/06 (20130101) B01L 2400/049 (20130101) B01L 2400/086 (20130101) B01L 2400/088 (20130101) B01L 2400/0487 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5304 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220362769 | Reiserer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ronald S. Reiserer (Nashville, Tennessee); David K. Schaffer (Nashville, Tennessee); Philip C. Samson (Nashville, Tennessee); Dmitry A. Markov (Nashville, Tennessee); Michael Geuy (Nashville, Tennessee); Lisa J. McCawley (Nashville, Tennessee); John P. Wikswo (Brentwood, Tennessee) |
| ABSTRACT | Microfluidic systems, pumps, valves and applications of the same are provided. The microfluidic system may be a pump or a valve having a fluidic chip and an actuator controlling the opening and closing of the fluidic channel in the fluidic chip. The actuator may be disposed to tilt from the fluidic chip, forming a tilted-rotor peristaltic pump. Alternatively, the actuator may be a rolling ball actuator, and different fluidic chips may be used in different applications. For example, the fluidic chip may be a spiral pump chip having spiral channels, a rotary peristaltic pump chip having multiple output channels, or a multi-port valve chip having one port interconnected with multiple different ports. An analytical valve chip may switchably interconnect bioreactor and rinse/calibration input channels to sensor and waste output channels. The actuator of a random-access valve can move from one valve position to another without opening or closing intermediate ones. |
| FILED | Monday, June 29, 2020 |
| APPL NO | 17/623350 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502738 (20130101) Original (OR) Class B01L 2300/123 (20130101) B01L 2300/0627 (20130101) B01L 2400/0644 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20220362776 | Seitter et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cerillo, LLC (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin Seitter (Charlottesville, Virginia); Kristin Schmidt (Charlottesville, Virginia); Thomas Moutinho, Jr. (Charlottesville, Virginia) |
| ABSTRACT | The present invention generally relates to a solid-state, multi-well plate reader including an emitter assembly having a plurality of emitters and a receptor assembly having a plurality of receptors, where the positions of these assemblies are not fixed relative to each other but are temporarily aligned for measurement by way of two alignment trays. |
| FILED | Monday, October 18, 2021 |
| APPL NO | 17/451162 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 3/502784 (20130101) Original (OR) Class B01L 2200/10 (20130101) B01L 2200/12 (20130101) B01L 2300/041 (20130101) B01L 2300/0654 (20130101) B01L 2300/0819 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/3563 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220363415 | Conn |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Orbital AI LLC (Detroit, Michigan) |
| ASSIGNEE(S) | Orbital AI LLC (Detroit, Michigan) |
| INVENTOR(S) | Tracie Renea Conn (Grosse Pointe Woods, Michigan) |
| ABSTRACT | The present disclosure provides a method for controlling orbital trajectories of a plurality of spacecraft in a multi-spacecraft swarm. In one aspect, the method includes deploying a DRL agent including a plurality of trajectory control models to the multi-spacecraft swarm, the trajectory control models corresponding to swarm configurations of the multi-spacecraft swarm; determining a state vector of said plurality of spacecraft in the multi-spacecraft swarm; transmitting a collective command to the multi-spacecraft swarm, such that said plurality of spacecraft in the multi-spacecraft swarm are to be distributed in one of the swarm configurations; determining actions of said plurality of spacecraft based on the state vector and the collective command; and maneuvering the multi-spacecraft swarm in accordance with the actions. |
| FILED | Wednesday, May 12, 2021 |
| APPL NO | 17/318390 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/242 (20130101) Original (OR) Class B64G 2001/245 (20130101) B64G 2001/247 (20130101) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 13/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Classified Government Agency
| US 20220365162 | Owen, III et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| ASSIGNEE(S) | BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| INVENTOR(S) | Joseph M. Owen, III (Merrimack, New Hampshire); Jeffrey L. Jew (Brookline, New Hampshire); Ian B. Murray (Amherst, New Hampshire) |
| ABSTRACT | A bi-static optical system utilizing a separate transmit and receive optical train that are identically steerable in azimuth-over-elevation fashion while accommodating an autoboresight technique and function. Further provided may be a common elevation assembly with two opposite-facing elevation fold mirrors on either side that are controlled by the same motor assembly allowing for common elevation control without overlapping or combining the apertures. |
| FILED | Tuesday, May 11, 2021 |
| APPL NO | 17/317436 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 3/7864 (20130101) Original (OR) Class Optical Elements, Systems, or Apparatus G02B 26/10 (20130101) G02B 26/0816 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20220361471 | Patch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE PENN STATE RESEARCH FOUNDATION (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Harland Patch (University Park, Pennsylvania); Nelson Daniel Troncoso Aldas (University Park, Pennsylvania); Eric Homan (University Park, Pennsylvania); Vijaykrishnan Narayanan (University Park, Pennsylvania); Codey Mathis (University Park, Pennsylvania); Chonghan Lee (University Park, Pennsylvania); Christina Grozinger (University Park, Pennsylvania) |
| ABSTRACT | An intelligent insect trap and identification system is disclosed. The intelligent insect trap and identification system can include an insect imaging chamber and identification system. The chamber can include a first cell for accepting insects, a second cell, a first reflector in the second cell, and a first imaging device in the second cell for recording one or more first visual images of the one or more insects in the first cell. Based on the image, the insect imaging chamber can detect and identify the insects. Other aspects, embodiments, and features are also claimed and described. |
| FILED | Wednesday, May 11, 2022 |
| APPL NO | 17/742350 |
| CURRENT CPC | Catching, Trapping or Scaring of Animals; Apparatus for the Destruction of Noxious Animals or Noxious Plants A01M 1/026 (20130101) Original (OR) Class Image or Video Recognition or Understanding G06V 10/25 (20220101) G06V 10/764 (20220101) G06V 40/10 (20220101) Pictorial Communication, e.g Television H04N 5/247 (20130101) H04N 7/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20220364144 | Polyakov et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States of America, as represented by Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sergey Vladimirovich Polyakov (Gaithersburg, Maryland); Ralph Jimenez (Boulder, Colorado) |
| ABSTRACT | A bioluminescent single photon bioreactor for performing absolute quantification of light-producing activity by enzymes includes: a bioreactor that produces a bio-electronic signal; an electronic sensor that receives the bio-electronic signal and produces an electrical transduction signal; and an analyzer that receives the electrical transduction signal and absolutely quantifies light-producing activity by enzymes from the electrical transduction signal, such that the absolute quantification is accomplished quantum mechanically by determination of a second order autocorrelation function. |
| FILED | Monday, November 01, 2021 |
| APPL NO | 17/515832 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502 (20130101) B01L 3/508 (20130101) B01L 2200/026 (20130101) B01L 2300/023 (20130101) B01L 2300/0654 (20130101) B01L 2300/0663 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 11/14 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/66 (20130101) Original (OR) Class Enzymes C12Y 113/12013 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/763 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 20220365033 | Poudel |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Transportation Technology Center, Inc. (Pueblo, Colorado) |
| ASSIGNEE(S) | Transportation Technology Center, Inc. (Pueblo, Colorado) |
| INVENTOR(S) | Anish Poudel (Oak Park, California) |
| ABSTRACT | A method for detecting breaks or defects in railroad spikes transmits an ultrasonic signal that propagates along the body of the spike and detects the resulting reflected ultrasonic signal. The reflected signal is then analyzed to automatically detect the presence of a break or defect in the spike based on the time delay between the reflected signal and the transmitted signal. |
| FILED | Tuesday, April 26, 2022 |
| APPL NO | 17/729595 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/07 (20130101) Original (OR) Class G01N 29/44 (20130101) G01N 29/048 (20130101) G01N 29/343 (20130101) G01N 2291/0234 (20130101) G01N 2291/2626 (20130101) Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 21/187 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Office of the Director of National Intelligence (ODNI)
| US 20220362769 | Reiserer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ronald S. Reiserer (Nashville, Tennessee); David K. Schaffer (Nashville, Tennessee); Philip C. Samson (Nashville, Tennessee); Dmitry A. Markov (Nashville, Tennessee); Michael Geuy (Nashville, Tennessee); Lisa J. McCawley (Nashville, Tennessee); John P. Wikswo (Brentwood, Tennessee) |
| ABSTRACT | Microfluidic systems, pumps, valves and applications of the same are provided. The microfluidic system may be a pump or a valve having a fluidic chip and an actuator controlling the opening and closing of the fluidic channel in the fluidic chip. The actuator may be disposed to tilt from the fluidic chip, forming a tilted-rotor peristaltic pump. Alternatively, the actuator may be a rolling ball actuator, and different fluidic chips may be used in different applications. For example, the fluidic chip may be a spiral pump chip having spiral channels, a rotary peristaltic pump chip having multiple output channels, or a multi-port valve chip having one port interconnected with multiple different ports. An analytical valve chip may switchably interconnect bioreactor and rinse/calibration input channels to sensor and waste output channels. The actuator of a random-access valve can move from one valve position to another without opening or closing intermediate ones. |
| FILED | Monday, June 29, 2020 |
| APPL NO | 17/623350 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502738 (20130101) Original (OR) Class B01L 2300/123 (20130101) B01L 2300/0627 (20130101) B01L 2400/0644 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20220361765 | CIMA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael J. CIMA (Winchester, Massachusetts); Matthew LI (Somerville, Massachusetts); Christophoros C. VASSILIOU (El Cerrito, California); Negar TAVASSOLIAN (Hoboken, New Jersey); Lina Avancini COLUCCI (Lexington, Massachusetts) |
| ABSTRACT | The invention features methods for detecting the hydration state or vascular volume of a subject using a device capable of nuclear magnetic resonance (NMR) measurement. The methods involve exposing a portion of a tissue of the subject in vivo to a magnetic field and RF pulse from the device to excite hydrogen nuclei of water within the tissue portion, and measuring a relaxation parameter of the hydrogen nuclei in the tissue portion, the relaxation parameter being a quantitative measure of the hydration state or vascular volume of the subject as a whole. The invention also features devices and computer-readable storage media for performing the methods of the invention. |
| FILED | Monday, May 02, 2022 |
| APPL NO | 17/734768 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/02 (20130101) A61B 5/055 (20130101) Original (OR) Class A61B 5/443 (20130101) A61B 5/4875 (20130101) A61B 5/6826 (20130101) A61B 5/14535 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/50 (20130101) G01R 33/383 (20130101) G01R 33/448 (20130101) G01R 33/4608 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220364585 | Griffin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | Raytheon Company (, None) |
| INVENTOR(S) | Eric J. Griffin (Rancho Palos Verdes, California); Aryan Blourchian (Mission Viejo, California) |
| ABSTRACT | An eccentric bushing assembly comprises an outer eccentric bushing configured to be disposed in an opening of a panel comprising a central axis. The outer eccentric bushing is operable to float axially, rotate circumferentially, and to move radially with respect to the central axis. The eccentric bushing assembly further comprises an inner eccentric bushing disposed radially inward from the outer eccentric bushing and interfacing with the outer eccentric bushing, the inner eccentric bushing is operable to rotate relative to the outer eccentric bushing. The eccentric bushing assembly further comprises a spherical bushing comprising a through hole operable to receive a connecting pin therein and to rotate in at least one degree of freedom. The rotation of the spherical bushing can facilitate alignment of an axis of the pin with the through hole. |
| FILED | Monday, May 17, 2021 |
| APPL NO | 17/322831 |
| CURRENT CPC | Finishing Work on Buildings, e.g Stairs, Floors E04F 13/0833 (20130101) Devices for Fastening or Securing Constructional Elements or Machine Parts Together, e.g Nails, Bolts, Circlips, Clamps, Clips, Wedges, Joints or Jointing F16B 12/2009 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220365215 | Greenberg et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | RAYTHEON COMPANY (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam Hodge Greenberg (Los Angeles, California); Eran Marcus (Culver City, California) |
| ABSTRACT | A target acquisition system includes a transmitter configured to emit a plurality of pulses at a plurality of transmit times toward a target, a receiver configured to detect a plurality of photon arrival events at a plurality of receive times, and a processor configured to determine a range of the target and a range-rate of the target by identifying a subset of the receive times and a subset of the transmit times, generating scaled transmit times based on the subset of the transmit times and a plurality of trial target velocities relative to the receiver, cross-correlating the scaled transmit times and the subset of the received times to generate a plurality of cross-correlation power values, and calculating the range and the range-rate of the target based on the plurality of cross-correlation power values. |
| FILED | Thursday, April 30, 2020 |
| APPL NO | 16/863064 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/4865 (20130101) G01S 17/58 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, November 17, 2022.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20221117.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page