FedInvent™ Patent Applications
Application Details for Thursday, November 24, 2022
This page was updated on Wednesday, November 30, 2022 at 12:38 PM GMT
Department of Health and Human Services (HHS)
| US 20220369610 | Wiles et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Jackson Laboratory (Bar Harbor, Maine) |
| ASSIGNEE(S) | The Jackson Laboratory (Bar Harbor, Maine) |
| INVENTOR(S) | Michael V. Wiles (Bar Harbor, Maine); Benjamin E. Low (Bar Harbor, Maine) |
| ABSTRACT | The present disclosure provides methods and compositions for high frequency mouse transgenesis using, for example, a Bxb1 landing pad. |
| FILED | Thursday, October 08, 2020 |
| APPL NO | 17/767311 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0278 (20130101) Original (OR) Class A01K 2207/15 (20130101) A01K 2217/072 (20130101) A01K 2227/105 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/907 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220369933 | Wang et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas D. Wang (Ann Arbor, Michigan); Xiyu Duan (San Jose, California); Haijun LI (Ann Arbor, Michigan) |
| ABSTRACT | An optical probe assembly as a confocal endomicroscope includes an optical focusing stage that focuses an output beam onto a sample and a mirror scanning stage that is movable for scanning the output beam in both a lateral two dimensional plane and an axial direction, using a side-view configuration. The side-view configuration allows for output beam illumination and fluorescent imaging of the sample with greater imaging resolution and improved access to hard to reach tissue within a subject. |
| FILED | Tuesday, July 24, 2018 |
| APPL NO | 16/633483 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/07 (20130101) A61B 1/043 (20130101) A61B 1/00096 (20130101) A61B 1/00172 (20130101) A61B 1/00177 (20130101) A61B 1/00193 (20130101) A61B 1/0623 (20130101) A61B 1/0638 (20130101) A61B 5/0068 (20130101) Original (OR) Class A61B 5/0071 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220369997 | Kraus et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois); Trustees of Dartmouth College (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nina Kraus (Evanston, Illinois); Jay C. Buckey (Hanover, New Hampshire); Abigail M. Fellows (Hanover, New Hampshire); Jennifer L. Krizman (Glencoe, Illinois); Trent G. Nicol (Libertyville, Illinois); Catherine C. Rieke (Hanover, New Hampshire); Travis White-Schwoch (Evanston, Illinois) |
| ABSTRACT | Central nervous (“CNS”) health in subjects who have human immunodeficiency virus (“HIV”) or non-human-species analogs thereof is 102 evaluated or otherwise monitored by analyzing frequency following response (“FFR”). In general, one or more components of an FFR are analyzed, The FFR is measured in response to the administration of an acoustic stimulus to the subject. The acoustic stimulus includes a complex sound, which may include a consonant and a consonant-to-vowel transition. An indication of CNS health can be generated by measuring changes in the FFR components (e.g., over time or relative to normative data). |
| FILED | Monday, June 08, 2020 |
| APPL NO | 17/596217 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/38 (20210101) A61B 5/291 (20210101) A61B 5/374 (20210101) A61B 5/4058 (20130101) Original (OR) Class A61B 2503/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370004 | Lue et al. |
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| FUNDED BY |
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| APPLICANT(S) | Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center (Torrance, California); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | YanHe Lue (Torrance, California); Boris Hyle Park (Torrance, California); Ronald Swerdloff (Torrance, California); Jacob Rajfer (Torrance, California); Christina Wang (Torrance, California); Junze Liu (Torrance, California) |
| ABSTRACT | Aspects of the methods include volumetrically imaging testicular tissue by optical coherence tomography to identify a testicular tissue location that is likely to contain sperm; and m-mode scanning using optical coherence tomography the identified testicular location to determine whether sperm are at least likely to be present at the location. Methods may further include harvesting sperm from the location, e.g., for use in in vitro fertilization. Also provided are devices and systems for practicing the methods. |
| FILED | Thursday, February 24, 2022 |
| APPL NO | 17/679516 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0066 (20130101) A61B 5/4387 (20130101) Original (OR) Class A61B 10/0058 (20130101) A61B 17/43 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370017 | DeMazumder et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Cincinnati (Cincinnati, Ohio) |
| ASSIGNEE(S) | University of Cincinnati (Cincinnati, Ohio) |
| INVENTOR(S) | Deeptankar DeMazumder (Baltimore, Maryland); Benjamin Vaughan (Cincinnati, Ohio) |
| ABSTRACT | Provided herein is a method for diagnosing and treating a subject at risk for atrial fibrillation (AF) or related health conditions, the method including: collecting one or more physiological signals from the subject in a sleep state or an awake state; extracting time series data from the one or more physiological signals; performing dynamic analyses of the time series data using artificial intelligence, wherein the artificial intelligence calculates a series of dynamic measurements, said dynamic measurements being indicative of a probability of an onset of an abnormal atrial rhythm; providing an integrated personalized risk score including the dynamic measurements, wherein the integrated personalized risk score is indicative of a probability of an onset of AF in the subject; diagnosing the subject as being at risk for AF when the integrated personalized risk score exceeds a threshold value, wherein the threshold value is calculated by the artificial intelligence based on a library of stored data; and treating the diagnosed subject with an effective therapy to prevent or treat AF or AF-related health conditions. |
| FILED | Monday, May 16, 2022 |
| APPL NO | 17/745690 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0205 (20130101) A61B 5/318 (20210101) A61B 5/02405 (20130101) A61B 5/4806 (20130101) A61B 5/7275 (20130101) Original (OR) Class Preparations for Medical, Dental, or Toilet Purposes A61K 31/7048 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370033 | Klingensmith et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Trustees of Southern Illinois University (Edwardsville, Illinois) |
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| INVENTOR(S) | Jon Klingensmith (Carbondale, Illinois); Colin Gibbons (Glen Carbon, Illinois); Michaela Kulasekara (Glen Carbon, Illinois) |
| ABSTRACT | A system for patient cardiac imaging and tissue modeling. The system includes a patient imaging device that can acquire patient cardiac imaging data. A processor is configured to receive the cardiac imaging data. A user interface and display allow a user to interact with the cardiac imaging data. The processor includes fat identification software conducting operations to interact with a trained learning network to identify fat tissue in the cardiac imaging data and to map fat tissue onto a three-dimensional model of the heart. A preferred system uses an ultrasound imaging device as the patient imaging device. Another preferred system uses an MRI or CT image device as the patient imaging device. |
| FILED | Wednesday, April 27, 2022 |
| APPL NO | 17/730380 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/7275 (20130101) A61B 8/085 (20130101) Original (OR) Class A61B 8/0858 (20130101) A61B 34/10 (20160201) A61B 2034/105 (20160201) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/30048 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370074 | Goldie et al. |
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| FUNDED BY |
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| APPLICANT(S) | Vivonics, Inc. (Bedford, Massachusetts) |
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| INVENTOR(S) | James H. Goldie (Lexington, Massachusetts); Brendan LaBrecque (Middleton, Massachusetts); Anna M. Galea (Stow, Massachusetts); Eric Klem (Lexington, Massachusetts); Thomas Doyle (Brentwood, Tennessee); Ian Cohen (Broomfield, Colorado); Tim Robinson (Sandown, New Hampshire); Dana Janssen (Brentwood, Tennessee); George Nicholson (Nashville, Tennessee) |
| ABSTRACT | A pulmonary artery flow restrictor system includes a funnel shaped membrane with a proximal base, a restrictive distal opening which is stretchable to larger sizes, an internal strut structure, and an external stent structure. |
| FILED | Tuesday, June 07, 2022 |
| APPL NO | 17/834351 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/12036 (20130101) Original (OR) Class A61B 17/12109 (20130101) A61B 17/12172 (20130101) A61B 17/12177 (20130101) A61B 2017/12054 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/82 (20130101) A61F 2002/068 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 29/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370086 | Szafron et al. |
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| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California); The Texas A and M University System (College Statin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason Szafron (Hamden, Connecticut); Duncan Maitland (College Station, Texas); Ward Small, IV (Livermore, California); Patrick R. Buckley (Livermore, California); Andrea D. Muschenborn (Bloomington, Indiana) |
| ABSTRACT | An embolectomy device comprised of an expansion unit and a support unit is disclosed. The expansion unit can be actuated in response to one or more external stimuli, and the support unit, located proximately to the expansion unit, provides a force to hold the expansion unit in place and to further induce the expansion unit's radial expansion. The radial expansion of the expansion unit causes the expansion unit to physically contact a blood clot, enabling the blood clot to be removed. In some embodiments, the expansion unit can be fabricated from a shape memory polymer foam. In some embodiments the support unit can be fabricated from any elastic material including, without limitation, shape memory alloys. |
| FILED | Friday, August 05, 2022 |
| APPL NO | 17/881684 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/22 (20130101) Original (OR) Class A61B 2017/2212 (20130101) A61B 2017/22094 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370154 | KRISHNASWAMY et al. |
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| APPLICANT(S) | THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire) |
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| INVENTOR(S) | Venkataramanan KRISHNASWAMY (Lebanon, New Hampshire); Richard J. BARTH, Jr. (Hanover, New Hampshire); Keith D. PAULSEN (Hanover, New Hampshire) |
| ABSTRACT | A method for guiding resection of local tissue from a patient includes generating at least one image of the patient, automatically determining a plurality of surgical guidance cues indicating three-dimensional spatial properties associated with the local tissue, and generating a visualization of the surgical guidance cues relative to the surface. A system for generating surgical guidance cues for resection of a local tissue from a patient includes a location module for processing at least one image of the patient to determine three-dimensional spatial properties of the local tissue, and a surgical cue generator for generating the surgical guidance cues based upon the three-dimensional spatial properties. A patient-specific locator form for guiding resection of local tissue from a patient includes a locator form surface matching surface of the patient, and a plurality of features indicating a plurality of surgical guidance cues, respectively. |
| FILED | Monday, July 25, 2022 |
| APPL NO | 17/872606 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 34/10 (20160201) A61B 34/20 (20160201) Original (OR) Class A61B 34/25 (20160201) A61B 90/361 (20160201) A61B 2017/008 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 7/33 (20170101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370310 | KELLER et al. |
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| FUNDED BY |
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| APPLICANT(S) | CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
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| INVENTOR(S) | Tobias KELLER (Holziken, Switzerland); Tanja BUDDE (Brittnau, Switzerland); Samuel RENTSCH (Spiegel bei Bern, Switzerland) |
| ABSTRACT | The present application is related to cancer immunotherapy, e.g. stimulation of T cell mediated anti-tumor therapy. Accordingly, described herein are methods of inducing or enhancing an adaptive immune response to a cancer in a subject and methods of treating cancer in a subject. In some embodiments, the methods hyperactivate dendritic cells (DCs), which induce T helper type I (TH1) and cytotoxic T lymphocyte (CTL) responses in the absence of TH2 immunity. |
| FILED | Wednesday, April 22, 2020 |
| APPL NO | 17/605160 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 8/19 (20130101) Original (OR) Class A61K 8/21 (20130101) A61K 8/0241 (20130101) A61K 2800/92 (20130101) Specific Use of Cosmetics or Similar Toilet Preparations A61Q 11/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370325 | MA et al. |
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| FUNDED BY |
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| APPLICANT(S) | OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio) |
| ASSIGNEE(S) | OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio) |
| INVENTOR(S) | Jianjie MA (POWELL, Ohio); Jianjun GUAN (WILDWOOD, Missouri); Haichang LI (DUBLIN, Ohio); Hong NIU (ST. LOUIS, Missouri); Ya GUAN (CLAYTON, Missouri); Tao TAN (COLUMBUS, Ohio) |
| ABSTRACT | Cosmeceutical compositions for and methods of improving the appearance of skin and promoting hair growth are provided. Said compositions comprise at least one ROS-scavenging polymer gel, at least MG53, or a combination thereof. A novel boronate ester-based copolymer forms an aqueous hydrogel exhibiting lower viscosity at cooler temperatures and higher viscosity at higher temperatures is provided. |
| FILED | Friday, July 22, 2022 |
| APPL NO | 17/871412 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 8/27 (20130101) A61K 8/042 (20130101) A61K 8/64 (20130101) Original (OR) Class A61K 8/8129 (20130101) Specific Use of Cosmetics or Similar Toilet Preparations A61Q 7/00 (20130101) A61Q 19/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370371 | Hanes et al. |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
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| INVENTOR(S) | Justin Hanes (Baltimore, Maryland); Barbara S. Slusher (Baltimore, Maryland); Anne Le (Baltimore, Maryland); Jie Fu (Baltimore, Maryland); Qingguo Xu (Baltimore, Maryland); Takashi Tsukamoto (Baltimore, Maryland) |
| ABSTRACT | Currently available glutaminase inhibitors are generally poorly soluble, metabolically unstable, and/or require high doses, which together reduce their efficacy and therapeutic index. These can be formulated into nanoparticles and delivered safely and effectively for treatment of pancreatic cancer and other glutamine addicted cancers. Studies demonstrate that nanoparticle delivery of BPTES, relative to use of BPTES alone, can be safely administered and provides dramatically improved tumor drug exposure, resulting in greater efficacy. GLS inhibitors can be administered in higher concentrations with sub-100 nm nanoparticles, since the nanoparticles package the drug into “soluble” colloidal nanoparticles, and the nanoparticles deliver higher drug exposure selectively to the tumors due to the enhanced permeability and retention (EPR) effect. These factors result in sustained drug levels above the IC50 within the tumors for days, providing significantly enhanced efficacy compared to unencapsulated drug. |
| FILED | Monday, December 06, 2021 |
| APPL NO | 17/543450 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/5146 (20130101) A61K 9/5153 (20130101) Original (OR) Class A61K 31/337 (20130101) A61K 31/433 (20130101) A61K 45/06 (20130101) Heterocyclic Compounds C07D 285/135 (20130101) C07D 417/12 (20130101) C07D 417/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370386 | Chandraratna et al. |
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| APPLICANT(S) | Io Therapeutics, Inc. (Spring, Texas); Trustees of Dartmouth College (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Roshantha A. Chandraratna (San Juan Capistrano, California); Ethan Dmitrovsky (Hanover, New Hampshire); Elizabeth Nowak (West Lebanon, New Hampshire); Randolph Noelle (Plainfield, New Hampshire); Martin E. Sanders (Spring, Texas) |
| ABSTRACT | The present specification provides RXR agonists with both remyelination promotion and immunomodulatory activities, compositions comprising such RXR agonists, and methods using such compounds and compositions to treat a demyelination-related disorder by both promoting remyelination of neurons and modulating the immune system. |
| FILED | Thursday, July 07, 2022 |
| APPL NO | 17/859743 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/47 (20130101) A61K 31/192 (20130101) Original (OR) Class A61K 31/216 (20130101) A61K 31/343 (20130101) A61K 31/353 (20130101) A61K 31/4704 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370388 | Colonna et al. |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marco Colonna (St. Louis, Missouri); Tyler Ulland (St. Louis, Missouri) |
| ABSTRACT | The present disclosure is directed to a method for treating a microglial dysfunction-associated neurodegenerative disease in a subject in need thereof. The method includes administering to the subject a therapeutically effective amount of a composition comprising a microglia receptor agonist that directly activates SYK. |
| FILED | Tuesday, June 14, 2022 |
| APPL NO | 17/840368 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/195 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6827 (20130101) C12Q 1/6883 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370406 | Rush |
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| FUNDED BY |
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| APPLICANT(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Craig R. Rush (Lexington, Kentucky) |
| ABSTRACT | Combinations and methods for treating a subject experiencing or at risk of experiencing an undesired consequence of stimulant use are provided. The combinations include topiramate and phentermine. The methods include administering an effective dose of a combination of topiramate and phentermine to a subject. In some embodiments, the methods include administering an effective dose of a combination of topiramate and phentermine to a subject with cocaine use disorder. |
| FILED | Wednesday, August 03, 2022 |
| APPL NO | 17/880101 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/137 (20130101) A61K 31/357 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370408 | MOR |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ADAM MOR (Cresskill, New Jersey) |
| ABSTRACT | Exemplary methods, compositions, kits and uses thereof for treating neoplasia are provided. For example, a method can be provided for treating neoplasia in a subject, including administering to the subject a VRK2 (vaccinia-related kinase 2) inhibitor, alone or in combination with an inhibitor of Programmed cell death receptor-1 (PD-1). The exemplary methods, compositions and kits may improve cancer immunotherapy. |
| FILED | Thursday, April 21, 2022 |
| APPL NO | 17/726120 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/381 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/136 (20130101) C12Q 2600/158 (20130101) C12Q 2600/178 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370410 | Garcia |
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| FUNDED BY |
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| APPLICANT(S) | The United States Government As Represented By The Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jose M. Garcia (Seattle, Washington) |
| ABSTRACT | Disclosed are methods of treating muscle loss in a subject comprising administering a therapeutically effective amount of a GHSR1a antagonist, a GHSR1a inverse agonist, a ghrelin antagonist, or a decoy ghrelin receptor to a subject in need thereof. Disclosed are methods of inhibiting the binding of ghrelin to GHSR1a (or GHSR1a to ghrelin) in a subject comprising administering a therapeutically effective amount of GHSR1a antagonist, GHSR1a inverse agonist, ghrelin antagonist, or decoy ghrelin receptor to a subject in need thereof. Also disclosed are methods of inhibiting the binding of ghrelin to GHSR1a (or GHSR1a to ghrelin) in a subject comprising mutating GHSR1a. Disclosed are methods of lowering proteasome activity in a subject comprising administering a therapeutically effective amount of a GHSR1a antagonist, a GHSR1a inverse agonist, a ghrelin antagonist, or a decoy ghrelin receptor to a subject in need thereof. Disclosed are methods of enhancing myogenesis in a subject comprising administering a therapeutically effective amount of a GHSR1a antagonist, a GHSR1a inverse agonist, a ghrelin antagonist, or a decoy ghrelin receptor to a subject in need thereof. Disclosed are methods of increasing mitochondrial biogenesis in a subject comprising administering a therapeutically effective amount of a GHSR1a antagonist, a GHSR1a inverse agonist, a ghrelin antagonist, or a decoy ghrelin receptor to a subject in need thereof. |
| FILED | Tuesday, May 24, 2022 |
| APPL NO | 17/752491 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/405 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370416 | Chu et al. |
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| FUNDED BY |
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| APPLICANT(S) | Arvinas Operations, Inc. (New Haven, Connecticut); Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ling Chu (Anhui, China PRC); Craig M. Crews (New Haven, Connecticut); Hanqing Dong (Madison, Connecticut); Keith R. Hornberger (Southbury, Connecticut); Jesus Raul Medina (Gilbertsville, Pennsylvania); Lawrence Snyder (Killingworth, Connecticut); Jing Wang (Milford, Connecticut) |
| ABSTRACT | Bifunctional compounds, which find utility as modulators of Kirsten ras sarcoma protein (KRas or KRAS), are described herein. In particular, the hetero-bifunctional compounds of the present disclosure contain on one end a moiety that binds to the Von Hippel-Lindau E3 ubiquitin ligase and on the other end a moiety which binds KRas, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The hetero-bifunctional compounds of the present disclosure exhibit a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aberrant regulation of the target protein are treated or prevented with compounds and compositions of the present disclosure. |
| FILED | Tuesday, April 06, 2021 |
| APPL NO | 17/223551 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/422 (20130101) A61K 31/427 (20130101) Original (OR) Class A61K 31/4155 (20130101) A61K 45/06 (20130101) A61K 47/545 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370434 | Chen et al. |
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| FUNDED BY |
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| APPLICANT(S) | City of Hope (Duarte, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jianjun Chen (Temple City, California); Rui Su (Monrovia, California); David Horne (Duarte, California); Xiaolan Deng (Temple City, California); Hongzhi Li (Duarte, California); Jun Xie (Duarte, California) |
| ABSTRACT | Provided, inter alia, are methods and compositions for treating FTO-mediated cancer. |
| FILED | Thursday, July 23, 2020 |
| APPL NO | 17/627059 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/47 (20130101) Original (OR) Class A61K 31/473 (20130101) A61K 31/495 (20130101) A61K 31/497 (20130101) A61K 31/704 (20130101) A61K 31/4178 (20130101) A61K 31/7068 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Heterocyclic Compounds C07D 215/52 (20130101) C07D 219/04 (20130101) C07D 233/52 (20130101) C07D 403/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370463 | Park-Min |
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| FUNDED BY |
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| APPLICANT(S) | New York Society for the Relief of the Ruptured and Crippled, Maintaining the Hospital for Special S (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kyung-Hyun Park-Min (Fort Lee, New Jersey) |
| ABSTRACT | Provided herein is a method of treating bone resorption associated with osteoclastic activity in a subject in need thereof. The method includes reducing the level of FMS intracellular fragments (FICDs) in the subject. |
| FILED | Friday, September 18, 2020 |
| APPL NO | 17/761027 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/52 (20130101) Original (OR) Class A61K 31/4439 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6863 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20220370464 — COMPOSITIONS AND METHODS OF TREATING OR PREVENTING OCULAR INFECTIONS WITH FILOCICLOVIR
| US 20220370464 | Hussein et al. |
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| FUNDED BY |
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| APPLICANT(S) | Microbiotix, Inc. (Worcester, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Islam Hussein (Marlboro, Massachusetts); Terry L. Bowlin (Maineville, Ohio); Richard Gauthier (Montreal, Canada) |
| ABSTRACT | The present invention is related to therapeutics and prophylactics for the treatment and/or prevention of ocular viral infections in humans and other mammals. Disclosed are methods of treating or preventing ocular viral infections in mammals, in particular caused by adenoviral infections, by administration of an effective amount of filociclovir (FCV). |
| FILED | Wednesday, June 24, 2020 |
| APPL NO | 17/622613 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/08 (20130101) A61K 9/0048 (20130101) A61K 31/522 (20130101) Original (OR) Class A61K 47/10 (20130101) A61K 47/44 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/12 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370471 | Du |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| INVENTOR(S) | Heng Du (Richardson, Texas) |
| ABSTRACT | Hippocampal lesions, including synaptic failure, are a defining pathology of Alzheimer's disease (AD). However, the molecular mechanisms that underlie hippocampal synaptic injury in this neurodegenerative disorder have yet not been fully elucidated. In Current therapeutic efforts for the treatment of AD are not effective in correcting hippocampal synaptic deficits. It is disclosed that the interaction with amyloid beta (Aβ) induces dysfunction of growth hormone secretagogue receptor 1a (GHSR1α; ghrelin receptor), leading to suppressed GHSR1α regulation of hippocampal dopamine receptor D1 (DRD1) in AD hippocampi. The modulation of DRD1 by GHSR1α impacts hippocampal synaptic plasticity. The simultaneous application of a selective GHSR1α agonist and a selective DRD1 agonist mitigates Aβ-induced hippocampal synaptic injury and improves spatial memory in AD mouse models. These data reveal a novel mechanism of hippocampal vulnerability in AD and that the combined activation of GHSR1α and DRD1 provides a new avenue for the pharmaceutical treatment of AD. |
| FILED | Thursday, August 13, 2020 |
| APPL NO | 17/634850 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/55 (20130101) Original (OR) Class A61K 31/438 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370479 | TONKS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | COLD SPRING HARBOR LABORATORY (Cold Spring Harbor, New York); DEPYMED, INC. (Farmingdalge, New York) |
| ASSIGNEE(S) | COLD SPRING HARBOR LABORATORY (Cold Spring Harbor, New York); DEPYMED, INC. (Farmingdale, New York) |
| INVENTOR(S) | Nicholas TONKS (Cold Spring Harbor, New York); Navasona KRISHNAN (Hawthorn Woods, Illinois); Andreas GRILL (Farmingdale, New York); Howard SARD (Woburn, Massachusetts) |
| ABSTRACT | Provided is a method of forming a copper-containing complex, including contacting a sample containing copper with a compound of Formula I: wherein R is —OH or —O—CH3. Also provided is a method of inhibiting enzymatic activity of a kinase in a sample, including contacting the sample with a compound of Formula I. Further provided is a method of administering to a subject a pharmaceutical composition including a compound of Formula I optionally complexed with copper. Also provided is a pharmaceutical composition including copper complexed with a compound of Formula I. |
| FILED | Monday, July 18, 2022 |
| APPL NO | 17/866724 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/58 (20130101) Original (OR) Class A61K 31/4184 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370486 | Burke et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin D. Burke (Champaign, Illinois); Chad M. Rienstra (Sun Prairie, Wisconsin); Jiabao Zhang (Urbana, Illinois) |
| ABSTRACT | Disclosed are compositions comprising a polyene macrolide antibiotic and an azole antifungal, and packaged pharmaceutical products comprising the disclosed compositions. Also disclosed are methods of treating systemic fungal infections comprising co-administering to a mammal a polyene macrolide antibiotic and an azole antifungal (conjoint administration). The co-administration may be simultaneous (e.g., in a single formulation or in separate formulations), sequential, or staggered. |
| FILED | Friday, August 07, 2020 |
| APPL NO | 17/633327 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/425 (20130101) A61K 31/4164 (20130101) A61K 31/7042 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370488 | Suk et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jung Soo Suk (Baltimore, Maryland); Yoo Chun Kim (Baltimore, Maryland); Justin Hanes (Baltimore, Maryland) |
| ABSTRACT | Mucus penetrating nanoparticles for inducing, increasing, or enhancing an immune response typically include core of a blend of a biodegradable hydrophobic polymer and a hydrophilic polymer, wherein ≥50% of the biodegradable polymer is conjugated to the hydrophilic polymer, and the hydrophilic polymers forms a coating on the particle. The particles encapsulate a cargo, typically an antigen, adjuvant or other immunomodulator, or a nucleic acid encoding the antigen, or combination thereof. Pharmaceutical compositions including an effective amount of particles to induce an immune response in a subject in need thereof are also provided. Methods of inducing an immune response are also provided, and typically include administering to a subject, preferably via the respiratory tract, the pharmaceutical composition. In some embodiments, the subject has cancer or an infection of the lung. |
| FILED | Wednesday, October 21, 2020 |
| APPL NO | 17/770437 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0034 (20130101) A61K 9/0053 (20130101) A61K 9/5107 (20130101) A61K 31/711 (20130101) Original (OR) Class A61K 47/6935 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370490 | Mirkin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chad A. Mirkin (Wilmette, Illinois); Ziyin Huang (Evanston, Illinois); Lisa Cole (Chicago, Illinois); Cassandra Elizabeth Callmann (Evanston, Illinois); Shuya Wang (Evanston, Illinois) |
| ABSTRACT | The present disclosure is generally directed to spherical nucleic acids (SNAs) comprising multiple TLR agonists that enable the simultaneous activation of multiple TLR pathways for maximally synergistic immune activation. In some aspects, the present disclosure provides a spherical nucleic acid (SNA) comprising: (a) a nanoparticle core; (b) one or more toll-like receptor 3 (TLR3) agonists encapsulated in the nanoparticle core; and (c) a shell of oligonucleotides attached to the external surface of the nanoparticle core, the shell of oligonucleotides comprising one or more toll-like receptor 9 (TLR9) agonist oligonucleotides. Methods of using the SNAs are also provided herein. |
| FILED | Friday, May 20, 2022 |
| APPL NO | 17/749977 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1275 (20130101) A61K 31/713 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370507 | YOON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | EMORY UNIVERSITY (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Young-Sup YOON (Atlanta, Georgia); Young-Doug SOHN (Atlanta, Georgia); Sang-Ho LEE (Atlanta, Georgia) |
| ABSTRACT | This disclosure relates to endothelial and smooth muscle like vascular tissue produced from urine cells. In certain embodiments, the disclosure relates to methods of producing endothelial and smooth muscle like vascular tissue by exposing urine derived cells with ETV2 in a first growth media under conditions such that the cells are modified to form a pool of cells expressing increased levels of endothelium surface markers and thereafter exposing the pool of cells to a second growth media under conditions such that the cells are modified to form tissue containing cells expressing increased levels of smooth muscle surface markers in addition to the endothelium surface markers. In certain embodiments, the disclosure relates to using cells and tissues reported herein for the treatment of vascular, cardiac, and wound healing indications. |
| FILED | Friday, July 10, 2020 |
| APPL NO | 17/761876 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/44 (20130101) Original (OR) Class Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/3625 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0691 (20130101) C12N 2500/32 (20130101) C12N 2500/34 (20130101) C12N 2500/38 (20130101) C12N 2500/46 (20130101) C12N 2501/11 (20130101) C12N 2501/39 (20130101) C12N 2501/91 (20130101) C12N 2501/115 (20130101) C12N 2501/165 (20130101) C12N 2506/25 (20130101) C12N 2513/00 (20130101) C12N 2710/10343 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370547 | Pamer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MEMORIAL SLOAN-KETTERING CANCER CENTER (New York, New York) |
| ASSIGNEE(S) | MEMORIAL SLOAN-KETTERING CANCER CENTER (New York, New York) |
| INVENTOR(S) | Eric Pamer (Montclair, New Jersey); Sohn Kim (New York, New York); Peter McKenney (New York, New York); Silvia Caballero (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure relates to novel lantibiotics, lantibiotic pharmaceutical compositions, isolated and recombinant lantibiotic-producing bacteria, bacterial pharmaceutical compositions, methods of producing novel lantibiotics from lantibiotic-producing bacteria, and methods of using such lantibiotics, lantibiotic pharmaceutical compositions, and bacterial pharmaceutical compositions to treat gram-positive bacteria infections, including vancomycin resistant enterococci infections, in patients, and to treat food and other objects to avoid gram-positive bacteria contamination. |
| FILED | Tuesday, December 28, 2021 |
| APPL NO | 17/563772 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/12 (20130101) Original (OR) Class A61K 38/443 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/00 (20130101) Enzymes C12Y 101/0112 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370552 | Bix |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregory J. Bix (Lexington, Kentucky) |
| ABSTRACT | The present invention relates to methods for enhancing recovery after an ischemic injury, including cerebral ischemia and stroke, by administration of therapeutic amounts of Domain V protein. |
| FILED | Friday, July 29, 2022 |
| APPL NO | 17/877378 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 38/1709 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370553 | RONAI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sanford Burnham Prebys Medical Discovery Institute (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ze'ev A. RONAI (Fallbrook, California); Scott PETERSON (Escondido, California); Yan LI (San Diego, California) |
| ABSTRACT | Described herein are methods and compositions for treating, reducing, or ameliorating cancer in a subject, comprising administering compositions comprising mucin and/or inulin. In some aspects, described herein is a method of enhancing anti-cancer immunity comprising: (a) administering to a subject a composition comprising mucin, wherein the subject has been identified as having a gut microbiome comprising one more microbial taxa that are members of a Clostridium cluster XIVa or an Actinobacteria phylum; and (b) altering the gut microbiome in the subject, wherein administration of the composition causes an enhanced anti-cancer immunity in the subject. |
| FILED | Thursday, July 30, 2020 |
| APPL NO | 17/627558 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/733 (20130101) A61K 38/1735 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370557 | ESPINO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PUERTO RICO (San Juan, Puerto Rico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ana M. ESPINO (San Juan, Puerto Rico); Jose J. ROSADO-FRANCO (San Juan, Puerto Rico) |
| ABSTRACT | The present disclosure reports that (1) recombinant Fh15 significantly prevented bacteremia, suppressed LPS levels in plasma and the production of C-reactive protein and procalcitonin, which are key signatures of inflammation and bacterial infection, respectively; (2) reduced the production of pro-inflammatory cytokines; and (3) increased innate immune cell populations in blood, which suggests a role in promoting a prolonged steady state in rhesus macaques even in the presence of inflammatory stimuli. This is the first report demonstrating that a F. hepatica-derived molecule possesses potential as anti-inflammatory drug against sepsis in an NHP-model. Prophylactic effects of rFh15 administered in a non-human preclinical primate model of sepsis support its use as a biotherapeutic. |
| FILED | Thursday, June 16, 2022 |
| APPL NO | 17/842599 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1767 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370560 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, A Body Corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiao-Jing Wang (Greenwood Village, Colorado); Qinghong Zhang (Englewood, Colorado); Yosef Refaeli (Denver, Colorado) |
| ABSTRACT | The present technology provides methods and compositions for the treatment of inflammatory and/or tissue damage conditions. In particular, the use of Smad7 compositions delivered locally or systemically to a site of inflammation and/or tissue damage is described. Other specific embodiments concern treatment or prevention of side effects caused by radiation and/or chemotherapy, including but not limited to oral and gastric mucositis. Also provided are codon-optimized nucleic acids encoding for Smad7 fusion proteins. |
| FILED | Friday, April 22, 2022 |
| APPL NO | 17/727579 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/18 (20130101) Original (OR) Class A61K 38/162 (20130101) A61K 48/005 (20130101) Peptides C07K 14/005 (20130101) C07K 14/475 (20130101) C07K 14/4702 (20130101) C07K 14/4703 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370566 | Butler et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Saint Louis University (St. Louis, Missouri); U.S.DEPARTMENT OF VETERANS' AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Alistair Butler (St. Louis, Missouri); Susan Farr (St. Louis, Missouri); Clemence Girardet (Paris, France) |
| ABSTRACT | Disclosed are methods and compositions for treating cognitive decline in subjects in need. More specifically, disclosed are methods of administrating exogenous adropin to subjects suffering from, or at risk of, cognitive decline including the aged and those suffering from traumatic brain injury. Also disclosed are subjects who would benefit from such treatment and pharmaceutical acceptable compositions comprising adropin, adropin34-76, and derivatives or variations thereof. |
| FILED | Tuesday, November 12, 2019 |
| APPL NO | 17/614035 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/22 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370591 | WISE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE WISTAR INSTITUTE OF ANATOMY and BIOLOGY (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Megan WISE (Plymouth Meeting, Pennsylvania); Daniel W. KULP (Moorestown, New Jersey); David B. WEINER (Merion, Pennsylvania) |
| ABSTRACT | Disclosed are compositions comprising an expressible nucleic acid sequence comprising a first nucleic acid sequence comprising a leader sequence or a pharmaceutically acceptable salt thereof; and a second nucleic acid sequence comprising a sequence that encodes a trimer of a retroviral envelope or a pharmaceutically acceptable salt thereof. In some embodiments, the expressible nucleic acid sequence further comprises a nucleic acid sequence encoding at least one viral antigen or a pharmaceutically acceptable salt thereof. In some embodiments, the expressible nucleic acid sequence further comprises at least one nucleic acid sequence encoding a linker. Also disclosed are pharmaceutical compositions comprising these compositions and methods of using the disclosed compositions. |
| FILED | Monday, April 06, 2020 |
| APPL NO | 17/601412 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class A61K 47/00 (20130101) A61K 2039/53 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370593 | Balint et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Etubics Corporation (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph P. Balint (Seattle, Washington); Frank R. Jones (Seattle, Washington); Richard B. Gayle, III (Seattle, Washington) |
| ABSTRACT | Methods for generating immune responses using adenovirus vectors that allow multiple vaccinations with the same adenovirus vector and vaccinations in individuals with preexisting immunity to adenovirus are provided. |
| FILED | Thursday, August 04, 2022 |
| APPL NO | 17/881131 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/191 (20130101) A61K 38/193 (20130101) A61K 38/204 (20130101) A61K 38/208 (20130101) A61K 38/217 (20130101) A61K 38/2013 (20130101) A61K 38/2026 (20130101) A61K 38/2033 (20130101) A61K 38/2046 (20130101) A61K 38/2066 (20130101) A61K 39/00 (20130101) A61K 39/0011 (20130101) A61K 39/12 (20130101) Original (OR) Class A61K 39/21 (20130101) A61K 39/235 (20130101) A61K 39/001106 (20180801) A61K 39/001182 (20180801) A61K 2039/54 (20130101) A61K 2039/57 (20130101) A61K 2039/545 (20130101) A61K 2039/575 (20130101) A61K 2039/5256 (20130101) A61K 2039/55555 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/005 (20130101) C07K 14/71 (20130101) C07K 14/70503 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2710/10034 (20130101) C12N 2710/10321 (20130101) C12N 2710/10334 (20130101) C12N 2710/10343 (20130101) C12N 2710/10371 (20130101) C12N 2710/20034 (20130101) C12N 2740/15034 (20130101) C12N 2740/16234 (20130101) C12N 2800/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370627 | KANNER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott KANNER (New York, New York); Henry M. COLECRAFT (New York, New York) |
| ABSTRACT | The present disclosure provides, inter alia, bivalent small molecules and methods for treating or ameliorating the effects of a disease, such as long QT syndrome, or cystic fibrosis, in a subject, using the bivalent small molecules disclosed herein. Also provided are methods of identifying and preparing small molecule binders that target proteins of interest. |
| FILED | Wednesday, July 13, 2022 |
| APPL NO | 17/864382 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/404 (20130101) A61K 47/55 (20170801) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1093 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370639 | Mendell et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NATIONWIDE CHILDREN'S HOSPITAL, INC. (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jerry R. Mendell (Columbus, Ohio); Louis Chicoine (Columbus, Ohio); Louise Rodino-Klapac (Columbus, Ohio); Kelly Reed Clark (Columbus, Ohio); Thomas J. Preston (Columbus, Ohio) |
| ABSTRACT | The present invention relates to recombinant adeno-associated virus (rAAV) delivery of an alpha-sarcoglycan gene. The invention provides rAAV products and methods of using the rAAV in the treatment of limb girdle muscular dystrophies such as LGMD2D. |
| FILED | Tuesday, May 17, 2022 |
| APPL NO | 17/746228 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) A61K 48/005 (20130101) A61K 48/0058 (20130101) Original (OR) Class A61K 48/0066 (20130101) A61K 48/0075 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/3603 (20140204) A61M 5/1408 (20130101) Peptides C07K 14/4707 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370683 | Andarawis-Puri |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nelly Andarawis-Puri (Ithaca, New York) |
| ABSTRACT | Provided are compositions and methods relating to methods and compositions to treat tendon injury. |
| FILED | Monday, May 23, 2022 |
| APPL NO | 17/751399 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/52 (20130101) A61L 27/54 (20130101) A61L 27/3633 (20130101) Original (OR) Class A61L 27/3662 (20130101) A61L 2300/414 (20130101) A61L 2430/10 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370686 | Di Carlo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Dino Di Carlo (Los Angeles, California); Westbrook Weaver (San Diego, California); Tatiana Segura (Durham, North Carolina); Jaekyung Koh (Los Angeles, California); Philip Scumpia (Los Angeles, California); Donald R. Griffin (Charlottesville, Virginia) |
| ABSTRACT | A hydrogel material for use in a human subject or other mammal includes a collection of microgel particles having one or more network cross linker components, wherein the microgel particles, when exposed to an endogenous or exogenous annealing agent, links the microgel particles together in situ to form a covalently-stabilized scaffold of microgel particles having pores formed between the microgel particles wherein the pores are substantially devoid of hydrogel. |
| FILED | Saturday, July 30, 2022 |
| APPL NO | 17/877933 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/1635 (20130101) A61K 9/1641 (20130101) A61K 9/1652 (20130101) A61K 39/39 (20130101) A61K 2039/60 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/52 (20130101) Original (OR) Class A61L 27/54 (20130101) A61L 27/56 (20130101) Derivatives of Natural Macromolecular Compounds C08H 1/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370687 | Lee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | Ki-Bum Lee (Monmouth Junction, New Jersey); Letao Yang (Piscataway, New Jersey) |
| ABSTRACT | A three dimensional scaffold for generating cell or protein assemblies. This degradable scaffold can be applied to various types of cells. Also disclosed are methods of treating a condition by implanting the protein or cell assembly prepared according to the method described herein. |
| FILED | Tuesday, May 24, 2022 |
| APPL NO | 17/664792 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/14 (20130101) A61L 27/025 (20130101) A61L 27/56 (20130101) Original (OR) Class A61L 2400/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370805 | Cogan et al. |
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| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina); New York University (, None); U.S. GOVENMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia); University of Utah Research Foundation (Salt Lake City, Utah); BLACKROCK MICROSYSTEMS, LLC dba (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregory Cogan (Durham, North Carolina); Jonathan Viventi (Durham, North Carolina); Nandan Lad (Durham, North Carolina); Bijan Pesaran (New York, New York); Virginia Woods (Durham, North Carolina); Chia-Han Chiang (Durham, North Carolina); Charles Wang (Durham, North Carolina); Katrina Barth (Durham, North Carolina); Werner Doyle (New York, New York); Patricia Dugan (New York, New York); Orrin Devinsky (New York, New York); Sasha Devore (New York, New York); Daniel Friedman (New York, New York); Amy Orsborn (New York, New York); Florian Solzbacher (Salt Lake City, Utah); Robert Franklin (Salt Lake City, Utah); Sandeep Negi (Salt Lake City, Utah); Saket Mulge (Salt Lake City, None) |
| ABSTRACT | The present disclosure provides systems and methods related to electroencephalography (EEG) electrode arrays. In particular, the present disclosure provides systems and methods relating to the manufacture and use of high-resolution electrocorticography (ECOG) electrode arrays and stereoelectroencephalography (SEEG) electrode arrays having various combinations and arrangements of microelectrodes and macroelectrodes for recording and modulating nervous system activity. |
| FILED | Friday, September 18, 2020 |
| APPL NO | 17/761369 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/36064 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220371009 | He et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaoming He (Bethesda, Maryland); Alisa White (Greenbelt, Maryland) |
| ABSTRACT | A system for selective microcapsule extraction includes a non-planar core-shell microfluidic device. The non-planar core-shell microfluidic device generates microcapsules defining a core-shell configuration. A subset of the microcapsules contain aggregates, tissues, or at least one cell. A camera captures images of the microcapsules. A detection module includes a processor and a memory. The memory includes instructions that when executed by the processor causes the detection module to provide the images of the microcapsules as an input to a machine learning model. The machine learning model identifies microcapsules containing aggregates, tissues, or at least one cell. A force generator generates a force to extract the microcapsules. A microcontroller selectively activates the force generator to generate the force when the detection module identifies a microcapsule containing aggregates, tissues, or at least one cell to extract the microcapsule. |
| FILED | Wednesday, April 20, 2022 |
| APPL NO | 17/725096 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) Original (OR) Class B01L 3/502715 (20130101) Image or Video Recognition or Understanding G06V 20/69 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220371547 | SHIN et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan); THE UNIVERSITY OF COLORADO (Denver, Colorado) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan); THE UNIVERSITY OF COLORADO (Denver, Colorado) |
| INVENTOR(S) | Kang G. SHIN (Ann Arbor, Michigan); Liang HE (Denver, Colorado) |
| ABSTRACT | A driving authentication system is presented for a vehicle. The system includes: a dongle interfaced with a battery of the vehicle and an authenticator configured to receive a discharge current from the battery. The dongle operates to modulate discharge current from the battery with an input code; and the authenticator demodulate the input code from the discharge current, compares the input code to the one or more known authentication codes and, in response to the input code matching one of the one or more known authentication codes, controls power capacity of the battery. |
| FILED | Thursday, March 24, 2022 |
| APPL NO | 17/703346 |
| CURRENT CPC | Vehicles, Vehicle Fittings, or Vehicle Parts, Not Otherwise Provided for B60R 25/04 (20130101) B60R 25/23 (20130101) Original (OR) Class B60R 25/1001 (20130101) Starting of Combustion Engines; Starting Aids for Such Engines, Not Otherwise Provided for F02N 11/087 (20130101) F02N 11/0862 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220371986 | Wang |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lei Wang (San Francisco, California) |
| ABSTRACT | Provided herein are, inter alia, methods of forming chemically reactive amino acids and methods of using same. |
| FILED | Friday, April 03, 2020 |
| APPL NO | 17/599907 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 227/16 (20130101) Original (OR) Class Peptides C07K 2/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 9/93 (20130101) C12N 15/70 (20130101) C12N 2800/101 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/02 (20130101) Enzymes C12Y 601/01026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372014 | Dawson et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland); Rapafusyn Research and Development, Inc. (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ted M. Dawson (Baltimore, Maryland); Valina L. Dawson (Baltimore, Maryland); Jun Liu (Baltimore, Maryland); Hyejin Park (Baltimore, Maryland); Tae-In Kam (Baltimore, Maryland); Hanjing Peng (Baltimore, Maryland); Venkata Subbarao Ayinampudi (Baltimore, Maryland); Sam Hong (Baltimore, Maryland); Brett Ullman (Baltimore, Maryland); Puneet Kumar (Baltimore, Maryland); Magesh Sadagopan (Baltimore, Maryland) |
| ABSTRACT | The present disclosure provides neuroprotective compounds along with their use in treating disease such as Parkinson's disease (PD). The compounds can be used as inhibitors for Parthanatos Associated AIF (apoptosis-inducing factor) Nuclease (PAAN), also known as macrophage migration inhibitor factor (MIF). |
| FILED | Wednesday, September 30, 2020 |
| APPL NO | 17/765418 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Heterocyclic Compounds C07D 401/06 (20130101) Original (OR) Class C07D 401/14 (20130101) C07D 405/14 (20130101) C07D 409/14 (20130101) C07D 413/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372079 | Lai et al. |
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| FUNDED BY |
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| APPLICANT(S) | Jonathan R. Lai (Dobbs Ferry, New York); Julia Frei (Brugg, Switzerland); Olivia Vergnolle (Jackson Heights, New York); Elisabeth Nyakatura (Jersey City, New York); George Georgiev (Bronx, New York); Ariel Wirchnianski (Bronx, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan R. Lai (Dobbs Ferry, New York); Julia Frei (Brugg, Switzerland); Olivia Vergnolle (Jackson Heights, New York); Elisabeth Nyakatura (Jersey City, New York); George Georgiev (Bronx, New York); Ariel Wirchnianski (Bronx, New York) |
| ABSTRACT | Specific resurfaced Dengue virus glycoprotein subunit E DIII variants and their uses in preventing and treating Dengue virus infection are disclosed. Provided herein are specific resurfaced Zika virus glycoprotein subunit E DIII variants and their uses in preventing and treating Zika virus infection. Multivalent vaccines comprising such resurfaced EDIII variants are also described, in addition to nanoparticle conjugated resurfaced EDIII variants. |
| FILED | Wednesday, June 24, 2020 |
| APPL NO | 17/621513 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2770/24122 (20130101) C12N 2770/24134 (20130101) C12N 2770/24171 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372096 | Merchant et al. |
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| FUNDED BY |
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| APPLICANT(S) | Medicenna Therapeutics Inc. (Toronto, Canada); The United States of America, as represented by the Secretary, Department of Health and Human Servic (Silver Spring, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fahar Merchant (Vancouver, Canada); Raj K. Puri (Potomac, Maryland); Joshi H. Bharatkumar (Rockville, Maryland) |
| ABSTRACT | The present invention relates to interleukin-4 receptor-binding fusion proteins. More specifically, the invention provides, in part, fusion proteins that include an interleukin-4 or interleukin-13 protein moiety joined to an anti-apoptotic Bcl-2 family member protein moiety. |
| FILED | Friday, May 06, 2022 |
| APPL NO | 17/738620 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/193 (20130101) A61K 38/1761 (20130101) A61K 38/2026 (20130101) Peptides C07K 14/4747 (20130101) C07K 14/5406 (20130101) Original (OR) Class C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0602 (20130101) C12N 5/0636 (20130101) C12N 15/63 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372101 | ROYBAL et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kole T. ROYBAL (Oakland, California); Raymond LIU (Oakland, California); Iowis ZHU (Oakland, California) |
| ABSTRACT | The present disclosure generally relates to, among other things, a new class of receptors engineered to modulate transcription in a ligand-dependent manner. The new receptors provide a selectable degree of noise, expression level, and signal to noise ratio. The disclosure also provides compositions and methods useful for producing such receptors, nucleic acids encoding same, host cells genetically modified with the nucleic acids, as well as methods for modulating an activity of a cell and/or for the treatment of various health conditions or diseases, such as cancers. |
| FILED | Wednesday, September 23, 2020 |
| APPL NO | 17/763110 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 38/22 (20130101) A61K 38/177 (20130101) A61K 38/1709 (20130101) A61K 38/1774 (20130101) A61K 39/3955 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 35/02 (20180101) Peptides C07K 14/47 (20130101) C07K 14/575 (20130101) C07K 14/705 (20130101) Original (OR) Class C07K 14/70517 (20130101) C07K 16/2803 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372102 | Yang et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Lili Yang (Los Angeles, California); Drake J. Smith (Los Angeles, California) |
| ABSTRACT | Disclosed herein are invariant natural killer T (iNKT) cells engineered using hematopoietic stem and progenitor cells (HSPCs) and methods of making and using thereof. |
| FILED | Wednesday, February 10, 2021 |
| APPL NO | 17/172925 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) A61K 2039/5154 (20130101) Peptides C07K 14/7051 (20130101) Original (OR) Class C07K 14/70503 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0646 (20130101) C12N 2506/11 (20130101) C12N 2510/00 (20130101) C12N 2740/13043 (20130101) C12N 2830/48 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372103 | Hinrichs et al. |
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| FUNDED BY |
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| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Christian S. Hinrichs (Bethesda, Maryland); Steven A. Rosenberg (Potomac, Maryland) |
| ABSTRACT | Disclosed is a synthetic T cell receptor (TCR) having antigenic specificity for an HLA-A2-restricted epitope of human papillomavirus (HPV) 16 E7, E711-19. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells are also provided. Antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention are also provided. Also disclosed are methods of detecting the presence of a condition in a mammal and methods of treating or preventing a condition in a mammal, wherein the condition is cancer, HPV 16 infection, or HPV-positive premalignancy. |
| FILED | Monday, August 01, 2022 |
| APPL NO | 17/816496 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/1774 (20130101) Peptides C07K 14/7051 (20130101) Original (OR) Class C07K 16/2809 (20130101) C07K 2319/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) G01N 33/57484 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372116 | Lai et al. |
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| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Samuel Lai (Carrboro, North Carolina); M. Gregory Forest (Chapel Hill, North Carolina); Christine Henry (Chapel Hill, North Carolina); Timothy Wessler (Durham, North Carolina); Alexander Chen (Glenville, New York); Jennifer Schiller (Chapel Hill, North Carolina); Jay Newby (Carrboro, North Carolina) |
| ABSTRACT | The presently-disclosed subject matter relates to crosslinkers, compositions, and methods for trapping a target of interest on a substrate of interest. The methods may be used to inhibit and treat pathogen infection and provide contraception. The methods may be used to trap or separate particles and other substances. The subject matter further relates to methods of identifying and preparing optimal crosslinkers and methods for manipulating targets of interest. |
| FILED | Friday, March 18, 2022 |
| APPL NO | 17/698645 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/00 (20180101) Peptides C07K 16/44 (20130101) C07K 16/087 (20130101) C07K 16/1045 (20130101) C07K 16/1235 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/557 (20130101) G01N 33/6854 (20130101) G01N 33/54346 (20130101) G01N 33/56983 (20130101) G01N 2333/16 (20130101) G01N 2333/4725 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372164 | Forman et al. |
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| FUNDED BY |
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| APPLICANT(S) | City of Hope (Duarte, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen J. Forman (Duarte, California); Christine E. Brown (Duarte, California); Uma Maheswara Rao Jonnalagadda (Troy, Michigan); Armen Mardiros (Glendale, California) |
| ABSTRACT | Chimeric antigen receptors that include an antigen recognition domain; a spacer domain derived from a modified immunoglobulin Fc region having one or more mutations in its CH2 region resulting in impaired binding to an FcR; and an intracellular signaling domain. |
| FILED | Monday, October 25, 2021 |
| APPL NO | 17/510099 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39558 (20130101) A61K 45/06 (20130101) A61K 2039/5156 (20130101) Peptides C07K 14/71 (20130101) C07K 14/7051 (20130101) C07K 14/70517 (20130101) C07K 14/70521 (20130101) C07K 16/00 (20130101) C07K 16/30 (20130101) Original (OR) Class C07K 16/2803 (20130101) C07K 16/2866 (20130101) C07K 2317/524 (20130101) C07K 2317/622 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372172 | Szeto et al. |
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| FUNDED BY |
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| APPLICANT(S) | Cornell Research Foundation, Inc. (New York, New York) |
| ASSIGNEE(S) | Cornell Research Foundation, Inc. (New York, New York) |
| INVENTOR(S) | Hazel H. Szeto (New York, New York); Kesheng Zhao (Jackson Heights, New York); Hugh Robertson (New York, New York); Alex V. Birk (New York, New York) |
| ABSTRACT | The invention relates to carrier complexes and methods for delivering molecules to cells. The carrier complexes comprises a molecule and an aromatic cationic peptide in accordance with the invention. In one embodiment, the method for delivering a molecule to a cell comprises contacting the cell with a carrier complex. In another embodiment, the method for delivering a molecule to a cell comprises contacting the cell with a molecule and an aromatic cationic peptide. |
| FILED | Monday, November 08, 2021 |
| APPL NO | 17/521425 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) A61K 38/47 (20130101) A61K 47/64 (20170801) A61K 47/645 (20170801) Peptides C07K 5/08 (20130101) C07K 5/1016 (20130101) C07K 5/1019 (20130101) C07K 17/00 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/96 (20130101) C12N 9/2471 (20130101) C12N 15/87 (20130101) C12N 15/113 (20130101) C12N 2310/3513 (20130101) C12N 2320/32 (20130101) Enzymes C12Y 302/01023 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372200 | GIANNESCHI et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | Northwestern University (Evanston, Illinois) |
| INVENTOR(S) | Nathan C. GIANNESCHI (Evanston, Illinois); Hao SUN (Evanston, Illinois) |
| ABSTRACT | Aspects of the invention include a method for synthesizing a peptide brush polymer, the method comprising: exposing a mixture comprising peptide-containing monomers, one or more photoinitiators, and one or more chain transfer agents to a light sufficient to induce photopolymerization, and photopolymerizing the peptide-containing monomers in the mixture; wherein: the resulting peptide brush polymer comprises at least one peptide-containing polymer block; the at least one peptide-containing polymer block is characterized by a degree of polymerization of at least 10 and a peptide graft density of 50% to 100%; and at least one peptide moiety of the at least one peptide-containing polymer block has 5 or more amino acid groups. |
| FILED | Tuesday, September 29, 2020 |
| APPL NO | 17/764746 |
| CURRENT CPC | Peptides C07K 1/1077 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 2/10 (20130101) C08F 2/50 (20130101) C08F 299/022 (20130101) Original (OR) Class C08F 2438/03 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372453 | STAMOS et al. |
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| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jennifer L. STAMOS (Austin, Texas); Alfred M. LENTZSCH (Austin, Texas); Seung Kuk PARK (Austin, Texas); Georg MOHR (Austin, Texas); Alan M. LAMBOWITZ (Austin, Texas) |
| ABSTRACT | A crystal structure of a Non-LTR-retroelement reverse transcriptase and methods of using the same to identify enzymes with improved activity are provided. Mutant reverse transcriptase enzymes and methods of using the same are also provided. |
| FILED | Tuesday, May 10, 2022 |
| APPL NO | 17/741437 |
| CURRENT CPC | Peptides C07K 2299/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1276 (20130101) Original (OR) Class Enzymes C12Y 207/07049 (20130101) Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 29/58 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372467 | Chatterjee et al. |
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| FUNDED BY |
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| APPLICANT(S) | TRUSTEES OF BOSTON COLLEGE (Chestnut Hill, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Abhishek Chatterjee (Lexington, Massachusetts); Rachel E. Kelemen (Newton, Massachusetts); Delilah Jewel (Chestnut Hill, Massachusetts) |
| ABSTRACT | The present invention involves the ability to 1) use a virus assisted directed evolution platform to significantly improve the activity of engineered nonsense-suppressor tRNAs in mammalian cells, 2) provide mutants of archaeal pyrrolysyl and E. coli leucyl tRNAs that show remarkably improved Uaa incorporation efficiency in mammalian cells, and 3) use these tRNAs to express recombinant proteins in mammalian cells incorporating Uaas at significantly improved yields. |
| FILED | Friday, June 19, 2020 |
| APPL NO | 17/620887 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/67 (20130101) C12N 15/86 (20130101) C12N 15/1058 (20130101) Original (OR) Class C12N 2750/14122 (20130101) C12N 2750/14143 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/02 (20130101) Enzymes C12Y 601/01026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372474 | Quijano et al. |
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| FUNDED BY |
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| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elias Quijano (Durham, Connecticut); Stanley Oyaghire (New Haven, Connecticut); W. Mark Saltzman (New Haven, Connecticut); Peter Glazer (Guilford, Connecticut) |
| ABSTRACT | Peptide nucleic acid (PNA) oligomers having one or more hydroxymethyl γ-substitutions, also referred to herein as “serγPNA”, are provided. The hydroxymethyl γ-substitution preserves and amplifies the helical preorganization that is valuable for DNA duplex invasion by the oligomer. serγPNA-containing triplex-forming molecules can be used in combination with a donor DNA fragment to facilitate genome modification in vitro and in vivo. |
| FILED | Monday, June 22, 2020 |
| APPL NO | 17/620358 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/14 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/15 (20130101) C12N 2310/3181 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372476 | Khvorova et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anastasia Khvorova (Westborough, Massachusetts); Bruno Miguel da Cruz Godinho (Worcester, Massachusetts); Matthew Hassler (Worcester, Massachusetts) |
| ABSTRACT | Therapeutic oligonucleotides comprising pharmacokinetic (PK)-modifying anchors are provided. Methods for treating diseases or disorders comprising administering to a subject a therapeutic oligonucleotide comprising one or more PK-modifying anchors are provided. |
| FILED | Wednesday, April 20, 2022 |
| APPL NO | 17/725102 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/14 (20130101) C12N 2310/314 (20130101) C12N 2310/315 (20130101) C12N 2310/321 (20130101) C12N 2310/322 (20130101) C12N 2310/351 (20130101) C12N 2310/531 (20130101) C12N 2310/3181 (20130101) C12N 2310/3231 (20130101) C12N 2310/3513 (20130101) C12N 2310/3515 (20130101) C12N 2320/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372480 | NGUYEN et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for The State University of New York (Amherst, New York); The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Juliane NGUYEN (Buffalo, New York); Scott FERGUSON (North Tonawanda, New York); Emily BONACQUISTI (Chapel Hill, North Carolina) |
| ABSTRACT | Provided are RNA polynucleotide sequences referred to as “EXO-Codes.” The RNA polynucleotides comprise one or more nucleotide sequences that facilitate preferential enrichment of secreted membranous vesicles that contain the EXO-Codes. Nucleotide motifs that contribute to these properties of the EXO-Codes are described. Modified eukaryotic cells comprising EXO-Codes are provided, and include lymphocytes such as T cells. EXO-Codes may comprise a cargo that provides a prophylactic or therapeutic effect. Exosome preparations comprising the EXO-codes are provided. Pharmaceutical compositions comprising EXO-Codes, expression vectors encoding them, and methods of using the pharmaceutical formulations are provided. The pharmaceutical compositions may comprise the EXO-Codes within membranous structures, such as exosomes. Cells that express or otherwise include the EXO-Codes are included, as are method for separating membranous structures that contain the EXO-codes from the cells. |
| FILED | Friday, October 30, 2020 |
| APPL NO | 17/772505 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/10 (20130101) C12N 2310/11 (20130101) C12N 2310/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372490 | ZHANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Health Research, Inc. (Butfalo, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yuesheng ZHANG (Orchard Park, New York); Yun LI (Orchard Park, New York); Lu YANG (Buffalo, New York) |
| ABSTRACT | Provided are methods for prophylaxis or therapy of cancer. The methods are directed to cancers that are characterized by expression of a mutant p53. The mutant p53 may be a loss of function p53 mutant, dominant negative p53 mutant, or a gain of function p53 mutant. The method comprises delivering to cancer cells an agent that can inhibit expression of prolidase (PEPD) or disrupts the association of mutant p53 with PEPD. |
| FILED | Friday, August 28, 2020 |
| APPL NO | 17/638518 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) Original (OR) Class C12N 2310/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372492 | Cruse et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina); The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| ASSIGNEE(S) | North Carolina State University (Raleigh, North Carolina); The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| INVENTOR(S) | Glenn P. Cruse (Apex, North Carolina); Dean D. Metcalfe (Bethesda, Maryland) |
| ABSTRACT | Methods for treating diseases and conditions mediated by the high affinity IgE receptor (FcεRI). Antisense oligomers for modulating splicing of mRNA encoding the FcεRIβ protein, thereby down-regulating cell-surface expression of FcεRI, and uses of the antisense oligomers for inhibiting mast cell degranulation, cytokine release, migration, and proliferation. |
| FILED | Monday, March 07, 2022 |
| APPL NO | 17/688618 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) C12N 15/1138 (20130101) Original (OR) Class C12N 2310/11 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372493 | GUO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peixuan GUO (Columbus, Ohio); Satheesh ELLIPILLI (Columbus, Ohio); Hongzhi WANG (Columbus, Ohio); Congcong XU (Columbus, Ohio); Xin LI (Columbus, Ohio) |
| ABSTRACT | Disclosed herein are compositions and methods for targeted treatment of liver cancers with Paclitaxel and miR-122. The disclosed composition comprises RNA nanostructure conjugated to a hepatocyte targeting ligand, paclitaxel, and miR-122 for use in intracellular drug delivery to liver cancer cells. The RNA nanoparticle can involve three or more self-assembled synthetic RNA oligonucleotides that form a central core domain and at least three double-stranded arms arranged around the core domain and extending away from the central core domain. |
| FILED | Thursday, December 17, 2020 |
| APPL NO | 17/757303 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/549 (20170801) A61K 47/6929 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) C12N 15/1138 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372511 | Tidball et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James G. Tidball (Los Angeles, California); Michelle Webhling-Henricks (Los Angeles, California); Steven Welc (Los Angeles, California) |
| ABSTRACT | Provided herein are polynucleotide constructs comprising a CD11b promoter operably linked to a nucleic acid encoding one or more therapeutic polypeptides, to vectors, cells, and/or compositions comprising the same, and to methods of their use. |
| FILED | Friday, June 12, 2020 |
| APPL NO | 17/618292 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) A61K 38/00 (20130101) Peptides C07K 14/715 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 2750/14143 (20130101) C12N 2830/008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372517 | STANKEY et al. |
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| FUNDED BY |
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| APPLICANT(S) | TERRA BIOWORKS, INC. (Middleton, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Joseph STANKEY (MADISON, Wisconsin); DAVID MEAD (MIDDLETON, Wisconsin) |
| ABSTRACT | Disclosed herein are recombinant methods of activating expression of one or more biosynthetic gene clusters comprising more than one gene, the method comprising a recombinant DNA expression vector that possess two opposable inducible promoters that drives expression of a biosynthetic gene cluster exogenously from outside of the cluster to produce polyketides or non-ribosomal peptides in a heterologous host. |
| FILED | Monday, July 18, 2022 |
| APPL NO | 17/813088 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/52 (20130101) C12N 15/70 (20130101) C12N 15/86 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372525 | Severinov et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts); Rutgers, The State University of New Jersey (New Brunswick, New Jersey); Skolkovo Institute of Science and Technology (Moscow Region, Russian Federation); The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Konstantin Severinov (New Brunswick, New Jersey); Feng Zhang (Cambridge, Massachusetts); Yuri I. Wolf (Bethesda, Maryland); Sergey Shmakov (Moscow, Russian Federation); Ekaterina Semenova (New Brunswick, New Jersey); Leonid Minakhin (New Brunswick, New Jersey); Kira S. Makarova (Bethesda, Maryland); Eugene Koonin (Bethesda, Maryland); Silvana Konermann (Cambridge, Massachusetts); Julia Joung (Cambridge, Massachusetts); Jonathan S. Gootenberg (Cambridge, Massachusetts); Omar O. Abudayyeh (Cambridge, Massachusetts); Eric S. Lander (Cambridge, Massachusetts) |
| ABSTRACT | The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA. |
| FILED | Friday, June 24, 2022 |
| APPL NO | 17/848563 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/63 (20130101) C12N 15/85 (20130101) C12N 15/102 (20130101) C12N 15/111 (20130101) C12N 15/113 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 15/8201 (20130101) C12N 2310/20 (20170501) C12N 2310/111 (20130101) C12N 2800/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372544 | M'KOMA |
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| FUNDED BY |
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| APPLICANT(S) | Meharry Medical College (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amosy M'KOMA (Antioch, Tennessee) |
| ABSTRACT | Methods and materials are disclosed for testing biomarkers in a subject suffering from inflammatory bowel disease (IBD) are described herein. Such detection can be useful for diagnosing and treating ulcerative colitis (UC) and Crohn's disease (CD), two forms of IBD that are otherwise difficult to distinguish. The method includes measuring the level of one or more of several biomarkers, including HD5 or MMP-7, which are expressed differentially in patents with UC and CD. A treatment may be based on the determination of whether the subject has ulcerative colitis or Crohn's disease. |
| FILED | Monday, July 25, 2022 |
| APPL NO | 17/872674 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/37 (20130101) Original (OR) Class C12Q 1/6837 (20130101) C12Q 1/6876 (20130101) C12Q 1/6883 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/60 (20130101) G01N 33/68 (20130101) G01N 33/582 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372551 | Setliff et al. |
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| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marion Francis Setliff (Nashville, Tennessee); Ivelin Stefanov Georgiev (Brentwood, Tennessee); Andrea Shiakolas (Nashville, Tennessee); Kelsey PILEWSKI (Nashville, Tennessee); Rohit VENKAT (Nashville, Tennessee) |
| ABSTRACT | The present disclosure relates to high-throughput systems and methods for the detection of ligand-blocking antibodies and for determining antibody potency. |
| FILED | Thursday, July 22, 2021 |
| APPL NO | 17/795104 |
| CURRENT CPC | Peptides C07K 16/1063 (20130101) C07K 2317/76 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/703 (20130101) C12Q 1/6806 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372553 | Madrid et al. |
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| FUNDED BY |
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| APPLICANT(S) | Andy Madrid (Madison, Wisconsin); Reid Spencer Alisch (Prairie du Sac, Wisconsin); Kirk Jeffrey Hogan (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andy Madrid (Madison, Wisconsin); Reid Spencer Alisch (Prairie du Sac, Wisconsin); Kirk Jeffrey Hogan (Madison, Wisconsin) |
| ABSTRACT | Provided herein is technology for Alzheimer's disease testing and particularly, but not exclusively, methods, compositions, and related uses for detecting the presence of Alzheimer's disease. |
| FILED | Friday, July 15, 2022 |
| APPL NO | 17/866284 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) Original (OR) Class C12Q 2600/154 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372576 | Quake et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen R. Quake (Stanford, California); Thomas M. Snyder (Palo Alto, California); Hannah Valantine (Stanford, California) |
| ABSTRACT | The invention provides methods, devices, compositions and kits for diagnosing or predicting transplant status or outcome in a subject who has received a transplant. |
| FILED | Thursday, June 09, 2022 |
| APPL NO | 17/836671 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6858 (20130101) C12Q 1/6883 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372582 | |
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| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Mingzhao Xing (Clarksville, Maryland) |
| ABSTRACT | The present invention relates to the field of cancer. More specifically, the present invention provides methods and compositions related to certain promoter mutations in cancer. In one embodiment, a method for treating a subject having thyroid cancer comprises the steps of (a) obtaining a biological sample from the subject (b) performing an assay on the sample obtained from the subject to identify a mutation at 1 295 228 C>T (C228T) and 1 295 250 C>T (C250T), corresponding to −124 C>T and −146 C>T from the translation start site in the promoter of the telomerase reverse transcriptase (TERT) gene; (c) identifying the subject as having or likely to develop aggressive thyroid cancer if the C228T and/or C250T mutation is identified; and (d) treating the subject with one or more treatment modalities appropriate for a subject having or likely to develop aggressive thyroid cancer. |
| FILED | Friday, June 03, 2022 |
| APPL NO | 17/831814 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/112 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372585 | Moon et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Tae Seok Moon (St. Louis, Missouri); Hyojeong Yi (St. Louis, Missouri); Matthew Amrofell (St. Louis, Missouri); Chenggang Xi (St. Louis, Missouri); Austin Rottinghaus (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Tae Seok Moon (St. Louis, Missouri); Hyojeong Yi (St. Louis, Missouri); Matthew Amrofell (St. Louis, Missouri); Chenggang Xi (St. Louis, Missouri); Austin Rottinghaus (St. Louis, Missouri) |
| ABSTRACT | Among the various aspects of the present disclosure is the provision of molecular sensors, microbial sensors, constructs, systems, and methods for selectively detecting aromatic compounds. |
| FILED | Wednesday, April 27, 2022 |
| APPL NO | 17/731195 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/02 (20130101) C12Q 1/6897 (20130101) Original (OR) Class Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/19 (20210501) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/9406 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372586 | Green et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander Green (Boston, Massachusetts); Fan Hong (Mesa, Arizona); Soma Chaudhary (Tempe, Arizona); Anli Tang (Gilbert, Arizona); Hao Yan (Chandler, Arizona) |
| ABSTRACT | Ultraspecific, programmable nucleic acid sensors capable of detecting and preferentially amplifying target DNA molecules comprising a particular SNP or mutation are provided. In some cases, the ultraspecific programmable nucleic acid sensors are useful for detecting SNP-containing DNA molecules indicative of cancer such as cell-free DNA circulating in the blood or indicative of organ transplant rejection Also provided are methods for construction of such ultraspecific nucleic acid sensors and methods for preferential amplification of target DNA molecules containing a mutation of interest, as well as testing systems for early cancer screening and routine monitoring of circulating cancer DNA using liquid biological samples such as serum, plasma, or saliva. |
| FILED | Wednesday, August 03, 2022 |
| APPL NO | 17/879871 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6858 (20130101) C12Q 1/6897 (20130101) Original (OR) Class C12Q 2525/301 (20130101) C12Q 2527/101 (20130101) C12Q 2531/101 (20130101) C12Q 2537/1373 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220373537 | XU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts); THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts); THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts) |
| INVENTOR(S) | Ke XU (Cambridge, Massachusetts); Marc E. LENBURG (Brookline, Massachusetts); Ehab BILLATOS (Milton, Massachusetts); Alejandro A. DIAZ (Boston, Massachusetts) |
| ABSTRACT | Described herein are methods relating to the diagnosis, prognosis, and treatment of airway dysfunction, e.g., bronchiectasis by detecting gene expression in a sample obtained from a subject. Exemplary samples include a bronchial brushing, nasal brushing, sputum, or peripheral blood sample. |
| FILED | Thursday, May 19, 2022 |
| APPL NO | 17/748404 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 2539/10 (20130101) C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5023 (20130101) Original (OR) Class G01N 2800/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220373548 | LaBaer et al. |
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| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joshua LaBaer (Chandler, Arizona); Lusheng Song (Tempe, Arizona); Ji Qiu (Chandler, Arizona); Yunro Chung (Chandler, Arizona) |
| ABSTRACT | Provided herein are methods, compositions, kits, and systems for detecting Epstein Barr virus infection (EBV) in gastric cancer (GC) patients. In particular, provided herein are methods, composition, kits, and systems for diagnosing and treating EBV-positive gastric cancer (EBV+ GC) in a biological sample of an individual based on the presence and level of antibodies against particular Epstein Barr virus proteins. EBV+ GC is a distinct subtype of gastric cancer and is associated with unique molecular profiles. Also provided herein are methods for providing more personalized therapy for each of these distinct cancer subtypes and methods for determining an Epstein Barr virus-positive gastric cancer antibody signature, and kits comprising components and protocols for performing the methods of this disclosure. |
| FILED | Friday, October 23, 2020 |
| APPL NO | 17/771595 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56994 (20130101) Original (OR) Class G01N 33/57446 (20130101) G01N 2333/05 (20130101) G01N 2474/10 (20210801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220373559 | Ranum et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| INVENTOR(S) | Laura Ranum (Gainesville, Florida); Lauren A. Laboissonniere (Gainesville, Florida); Lien Nguyen (Gainesville, Florida) |
| ABSTRACT | Aspects of the disclosure relate to methods and compositions (e.g., kits) for detecting anti-repeat-associated non-ATG (RAN) protein antibodies in a subject (e.g., a subject that has been administered a therapeutic anti-RAN protein antibody or a vaccine against a disease or disorder associated with RAN protein expression, translation, and/or accumulation, for example amyotrophic lateral sclerosis (ALS) and/or frontotemporal dementia (FTD)). In some embodiments, methods described by the disclosure comprise detecting one or more anti-RAN protein antibodies in a biological sample obtained from a subject by an electrochemiluminescence-based immunoassay using one or more target di-amino acid repeat peptides. In some embodiments, the disclosure relates to kits comprising one or more di-amino acid repeat peptides and an electrochemiluminescence-based immunoassay plate and/or reagents. |
| FILED | Friday, September 18, 2020 |
| APPL NO | 17/761764 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/66 (20130101) G01N 33/6854 (20130101) Original (OR) Class G01N 33/54366 (20130101) G01N 2458/30 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220373561 | JOHNSTON |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen Albert JOHNSTON (Tempe, Arizona) |
| ABSTRACT | A method of producing a set of high affinity peptides for detecting one or more antibodies associated with a disease or condition of interest. The method including identifying a set of informative peptides correlated to the disease or condition of interest and translating the set of informative peptides to one or more high affinity peptides for an antibody of interest, wherein the presence of the antibody of interest identifies a subject as having the disease or condition of interest. A diagnostic peptide array produced from the one or more high affinity. A method of detecting an antibody associated with a disease of condition, including: contacting a biological sample with a diagnostic peptide array; and detecting the binding of one or more antibodies to a peptide that is associated with a disease or condition of interest, thereby detecting the antibody associated with a disease of condition. |
| FILED | Monday, August 01, 2022 |
| APPL NO | 17/816637 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6845 (20130101) G01N 33/6854 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220373627 | Wang et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| INVENTOR(S) | Zhixing Wang (Charlottesville, Virginia); Steven P. Allen (Charlottesville, Virginia); Xue Feng (Zion Crossroads, Virginia); John P. Mugler, III (Charlottesville, Virginia); Craig H. Meyer (Charlottesville, Virginia) |
| ABSTRACT | Methods, computing devices, and magnetic resonance imaging systems that improve image quality in turbo spiral echo (TSE) imaging are disclosed. With this technology, a TSE pulse sequence is generated that includes a series of radio frequency (RF) refocusing pulses to produce a corresponding series of nuclear magnetic resonance (NMR) spin echo signals. A gradient waveform including a plurality of segments is generated. The plurality of segments collectively comprise a spiral ring retraced in-out trajectory. During an interval adjacent to each of the series of RF refocusing pulses, a first gradient pulse is generated according to the gradient waveform. The first gradient pulses encode the NMR spin echo signals. An image is then constructed from digitized samples of the NMR spin echo signals obtained based at least in part on the encoding. |
| FILED | Thursday, April 28, 2022 |
| APPL NO | 17/732181 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/482 (20130101) Original (OR) Class G01R 33/543 (20130101) G01R 33/5608 (20130101) G01R 33/5617 (20130101) G01R 33/56509 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220373630 | Dou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Quan Dou (Charlottesville, Virginia); Zhixing Wang (Charlottesville, Virginia); Xue Feng (Zion Crossroads, Virginia); John P. Mugler, III (Charlottesville, Virginia); Craig H. Meyer (Charlottesville, Virginia) |
| ABSTRACT | Training a neural network to correct motion-induced artifacts in magnetic resonance images includes acquiring motion-free magnetic resonance image (MRI) data of a target object and applying a spatial transformation matrix to the motion-free MRI data. Multiple frames of MRI data are produced having respective motion states. A Non-uniform Fast Fourier Transform (NUFFT) can be applied to generate respective k-space data sets corresponding to each of the multiple frames of MRI; the respective k-space data sets can be combined to produce a motion-corrupted k-space data set and an adjoint NUFFT can be applied to the motion-corrupted k-space data set. Updated frames of motion-corrupted MRI data can be formed. Using the updated frames of motion corrupted MRI data, a neural network can be trained that generates output frames of motion free MRI data; and the neural network can be saved. |
| FILED | Friday, April 29, 2022 |
| APPL NO | 17/733967 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/5608 (20130101) Original (OR) Class G01R 33/5611 (20130101) Image Data Processing or Generation, in General G06T 2207/10088 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220375082 | Chatterjee et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE UNIVERSITY OF CHICAGO (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aritrick Chatterjee (Chicago, Illinois); Gregory S. Karczmar (Crete, Illinois); Aytekin Oto (Chicago, Illinois); Xiaobing Fan (Darien, Illinois) |
| ABSTRACT | A diagnostic system to analyze imaging data includes a memory configured to store hybrid imaging data of a tissue sample. The system also includes a processor operatively coupled to the memory and configured to generate a four quadrant plot based on the hybrid imaging data. Each point in the four quadrant plot corresponds to an image voxel of the tissue sample. The processor is also configured to determine one or more angle values and one or more distance values for image voxels in the four quadrant plot. The processor is further configured to identify one or more characteristics of the tissue sample based at least in part on the one or more angle values and the one or more distance values. The processor is further configured to perform a matrix analysis of the data, which can be used to identify the one or more characteristics of the tissue sample. |
| FILED | Wednesday, November 11, 2020 |
| APPL NO | 17/771957 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/5602 (20130101) G01R 33/56341 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 2207/10088 (20130101) G06T 2207/30096 (20130101) Image or Video Recognition or Understanding G06V 10/76 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220375141 | Sandino et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Michael Sandino (Menlo Park, California); Shreyas S. Vasanawala (Stanford, California); Frank Ong (Palo Alto, California) |
| ABSTRACT | A method for MR imaging includes acquiring with an MR imaging apparatus undersampled k-space imaging data having one or more temporal dimensions and two or more spatial dimensions; transforming the undersampled k-space imaging data to image space data using zero-filled or sliding window reconstruction and sensitivity maps; decomposing the image space data into a compressed representation comprising a product of spatial and temporal parts, where the spatial part comprises spatial basis functions and the temporal part comprises temporal basis functions; processing the spatial basis functions and temporal basis functions to produce reconstructed spatial basis functions and reconstructed temporal basis functions, wherein the processing iteratively applies conjugate gradient and convolutional neural network updates using 2D or 3D spatial and 1D temporal networks; and decompressing the reconstructed spatial basis functions and reconstructed temporal basis functions to produce a reconstructed MRI image having one or more temporal dimensions and two or more spatial dimensions. |
| FILED | Thursday, May 13, 2021 |
| APPL NO | 17/319316 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/7264 (20130101) Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 11/006 (20130101) Original (OR) Class G06T 2207/10088 (20130101) G06T 2207/20021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220375142 | Xie et al. |
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| FUNDED BY |
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| APPLICANT(S) | Huidong Xie (Troy, New York); Ge Wang (Loudonville, New York); Hongming Shan (Troy, New York); Wenxiang Cong (Albany, New York) |
| ASSIGNEE(S) | RENSSELAER POLYTECHNIC INSTITUTE (TROY, New York) |
| INVENTOR(S) | Huidong Xie (Troy, New York); Ge Wang (Loudonville, New York); Hongming Shan (Troy, New York); Wenxiang Cong (Albany, New York) |
| ABSTRACT | A system for few-view computed tomography (CT) image reconstruction is described. The system includes a preprocessing module, a first generator network, and a discriminator network. The preprocessing module is configured to apply a ramp filter to an input sinogram to yield a filtered sinogram. The first generator network is configured to receive the filtered sinogram, to learn a filtered back-projection operation and to provide a first reconstructed image as output. The first reconstructed image corresponds to the input sinogram. The discriminator network is configured to determine whether a received image corresponds to the first reconstructed image or a corresponding ground truth image. The generator network and the discriminator network correspond to a Wasserstein generative adversarial network (WGAN). The WGAN is optimized using an objective function based, at least in part, on a Wasserstein distance and based, at least in part, on a gradient penalty. |
| FILED | Monday, September 14, 2020 |
| APPL NO | 17/642725 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 11/005 (20130101) G06T 11/006 (20130101) Original (OR) Class G06T 2211/421 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220375540 | Chabon et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Jacob J. Chabon (Arvad, Colorado); David M. Kurtz (San Carlos, California); Maximilian Diehn (San Carlos, California); Arash Ash Alizadeh (San Mateo, California) |
| ABSTRACT | Processes and materials to detect cancer, transplant rejection, or fetal genetic abnormalities from a biopsy are described. In some cases, nucleic acid molecules, such as cell-free nucleic acids, can be sequenced, and the sequencing result can be utilized to detect sequences indicative of a neoplasm, transplant rejection, or fetal genetic abnormality. Detection of somatic variants occurring in phase and/or insertions and deletions (indels) can indicate the presence of cancer, transplant rejection, or fetal genetic abnormalities in a diagnostic scan, and a clinical intervention can be performed. |
| FILED | Wednesday, April 27, 2022 |
| APPL NO | 17/661034 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) C12Q 1/6886 (20130101) C12Q 2600/156 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/20 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220375542 | Grant |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam David Grant (Tucson, Arizona) |
| ABSTRACT | Systems and methods are described for genetic analysis. In certain embodiments, the system reads a plurality of input parameters, where the input parameters include a file-path to a mutation input file and storing the mutation input file. The mutation input file is comprised of a mutated genetic sequence, and the sorting mutations in the mutation input file are based on starting position. The computer then receives data identifying chromosome location, start position, reference allele and mutated allele for each mutation within the mutation input file and loads a standardized reference genome. In certain embodiments, the GTF file identifies the location of mutated genes in the input standardized reference genome. The system then compares the mutation input file to the standardized reference genome and generates a mutation index file. The mutation index file identifies mutated nucleotides in the customized reference genome and can be used to quantify allelic expression to diagnose a genetic condition like cancer and improve therapeutic options for cancer patients. |
| FILED | Wednesday, May 18, 2022 |
| APPL NO | 17/747796 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/50 (20190201) Original (OR) Class G16B 30/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220375545 | Grant |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Arizona, Tech Transfer Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam David Grant (Tucson, Arizona) |
| ABSTRACT | Systems and methods are described for genetic analysis. In certain embodiments, the system reads a plurality of input parameters, where the input parameters comprise a path to a gene fusion input file and stores the gene fusion input file. The gene fusion input file is comprised of break points of genetic sequences for one or more gene fusion events. The computer then receives data identifying chromosome location, start position, end position, and strand for each gene in the gene fusion input file and loads a standardized reference genome. The computer then compares the gene fusion input file to the standardized reference genome and generates a gene fusion index file. The gene fusion index file identifies gene fusion events in the customized reference genome and can be used to quantify the number or next generation sequencing reads aligned to the wild type allele and fused allele. Allelic expression of tumor fusions can be used to diagnose a genetic condition and enhance therapeutic options for cancer patients. |
| FILED | Wednesday, May 18, 2022 |
| APPL NO | 17/747817 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/20 (20190201) G16B 30/10 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220375609 | Guo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NemaMetrix, Inc (Eugene, Oregon) |
| ASSIGNEE(S) | NemaMetrix, Inc. (Eugene, Oregon) |
| INVENTOR(S) | Lan Guo (Eugene, Oregon); Stephen Turner (Eugene, Oregon); Trisha Brock (Eugene, Oregon); Chris HOPKINS (Corvallis, Oregon) |
| ABSTRACT | Disclosed herein are classifier models, computer implemented systems, machine learning systems and methods thereof for classifying clinical variants of unknown or uncertain significance into a pathogenicity category using measured phenotype features extracted from phenotype assays of transgenic organism expressing the human clinical variant. Embodiments of the present invention relate generally to methods for generating classifier models using machine learning and use of those classifier models to predict the pathogenicity of a clinical variant for a specific human disease (e.g. genetic disease), assigning a patient clinical variant to a pathogenicity category (e.g. pathogenic or benign) for the specific human disease to determine whether that patient should be followed up with additional, more invasive diagnostic testing, or treatment. |
| FILED | Thursday, October 15, 2020 |
| APPL NO | 17/769727 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/40 (20190201) G16B 40/20 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) Original (OR) Class G16H 70/60 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220377560 | ZENG |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTH CAROLINA (Columbia, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | QIANG ZENG (WEST COLUMBIA, South Carolina) |
| ABSTRACT | Secure pairing is key to trustworthy deployment and application of Internet of Things (IoT) devices. However, IoT devices lack conventional user interfaces, such as keyboards and displays, which make many traditional pairing approaches inapplicable. Proximity-based pairing approaches are very usable, but can be exploited by co-located malicious devices. Approaches based on a user's physical operations on IoT devices are more secure, but typically require inertial sensors, while many devices do not satisfy this requirement. A secure and usable pairing approach that can be applied to heterogeneous IoT devices still does not exist. We develop a technique, Universal Operation Sensing, which allows an IoT device to sense the user's physical operations on it without requiring inertial sensors. With this technique, a user holding a smartphone or wearing a wristband can finish pairing in seconds through some very simple operations, e.g., pressing a button or twisting a knob. Moreover, we reveal an inaccuracy issue in original fuzzy commitment and propose faithful fuzzy commitment to resolve it. We design a pairing protocol using faithful fuzzy commitment, and build a prototype system named Touch-to-Pair (T2Pair, for short). The comprehensive evaluation shows that it is secure and usable. |
| FILED | Thursday, March 10, 2022 |
| APPL NO | 17/691697 |
| CURRENT CPC | Wireless Communication Networks H04W 12/06 (20130101) H04W 12/50 (20210101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20220370553 | RONAI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sanford Burnham Prebys Medical Discovery Institute (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ze'ev A. RONAI (Fallbrook, California); Scott PETERSON (Escondido, California); Yan LI (San Diego, California) |
| ABSTRACT | Described herein are methods and compositions for treating, reducing, or ameliorating cancer in a subject, comprising administering compositions comprising mucin and/or inulin. In some aspects, described herein is a method of enhancing anti-cancer immunity comprising: (a) administering to a subject a composition comprising mucin, wherein the subject has been identified as having a gut microbiome comprising one more microbial taxa that are members of a Clostridium cluster XIVa or an Actinobacteria phylum; and (b) altering the gut microbiome in the subject, wherein administration of the composition causes an enhanced anti-cancer immunity in the subject. |
| FILED | Thursday, July 30, 2020 |
| APPL NO | 17/627558 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/733 (20130101) A61K 38/1735 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370780 | Donaldson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Critical Innovations, LLC (Lawndale, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ross I. Donaldson (Lawndale, California); Oliver Buchanan (Lawndale, California); Tim Fisher (Lawndale, California); Jon Armstrong (Lawndale, California); John Cambridge (Lawndale, California) |
| ABSTRACT | An improved method and device are provided for forming and/or maintaining a percutaneous access pathway. The device generally comprises an access pathway and attachment device. The provided assembly substantially reduces the possibility of iatrogenic infection while accessing and/or re-accessing a body space. |
| FILED | Thursday, August 04, 2022 |
| APPL NO | 17/881298 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/34 (20130101) A61B 17/3415 (20130101) A61B 17/3423 (20130101) A61B 17/3498 (20130101) A61B 90/40 (20160201) A61B 2017/00809 (20130101) A61B 2017/3492 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 39/0247 (20130101) Original (OR) Class A61M 2210/101 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370804 | Welle et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cristin Welle (Denver, Colorado); Ethan Hughes (Denver, Colorado); Rongchen Huang (Fort Collins, Colorado) |
| ABSTRACT | Embodiments of the instant invention relate to applying motor learning to promote remyelination following demyelination in a subject having a condition or disease. In certain embodiments, applying motor learning alone or in combination with vagus nerve stimulation (VNS) induces the production of new and preserves surviving oligodendrocytes. In accordance with certain embodiments of the disclosure, motor learning, when properly timed, enhances oligodendrogenesis after injury and recruits mature oligodendrocytes to participate in remyelination through the generation of new myelin sheaths. In other aspects of the disclosure, VNS paired with motor learning enhances remyelination following demyelination. |
| FILED | Friday, January 21, 2022 |
| APPL NO | 17/581307 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 29/005 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/3606 (20130101) A61N 1/36025 (20130101) A61N 1/36034 (20170801) A61N 1/36053 (20130101) Original (OR) Class A61N 1/36157 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370978 | Long et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Jeffrey W. Long (Alexandria, Virginia); Christopher N. Chervin (Washington, District of Columbia); Robert B. Balow (Mount Ranier, Maryland); Jeffrey C. Owrutsky (Silver Spring, Maryland); Debra R. Rolison (Arlington, Virginia); Kenan O. Fears (Alexandria, Virginia) |
| ABSTRACT | Disclosed is a method of decontamination by exposing a zirconium oxy(hydroxide) aerogel to a liquid, vapor, or gaseous sample suspected of containing a phosphonate compound. The aerogel may be doped with Fe3+ ions, Ce3+ ions, or SO42− ions. The aerogel may be made by: providing a solution of ZrCl4; FeCl3, CeCl3, or Zr(SO4)2; and a solvent; adding a cyclic ether to the solution to form a gel; infiltrating the gel with liquid carbon dioxide; applying a temperature and pressure to form supercritical fluid carbon dioxide; and removing the carbon dioxide for form an aerogel. |
| FILED | Thursday, August 04, 2022 |
| APPL NO | 17/817477 |
| CURRENT CPC | Chemical Means for Extinguishing Fires or for Combating or Protecting Against Harmful Chemical Agents; Chemical Materials for Use in Breathing Apparatus A62D 3/33 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/06 (20130101) Original (OR) Class B01J 20/0207 (20130101) B01J 20/0229 (20130101) B01J 20/0281 (20130101) B01J 20/28047 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370991 | Emdadi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | U.S. Army DEVCOM Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Laleh Emdadi (Centreville, Virginia); Dat T. Tran (Clarksville, Maryland); Sampath Gunukula (Beltsville, Maryland) |
| ABSTRACT | Incorporating a bimetal to a lamellar MFI zeolite structure includes providing a bimetallic-incorporated lamellar zeolite catalyst including a sodium source, aluminum source, silicon source, surfactant, sulfuric acid, deionized water, metal source, and molecular template; dissolving the sodium source in the deionized water creating a basic solution; adding the sulfuric acid, aluminum source, molecular template, and silicon source to the basic solution creating a mixture and adding the metal source to the mixture; dissolving the surfactant in the deionized water creating a surfactant solution; combining the surfactant solution and basic solution; heating the combined surfactant solution and basic solution in a rotating autoclave creating a metal-containing zeolite including the surfactant and molecular template in a structure of the metal-containing zeolite; removing a synthesized zeolite from the autoclave; drying the synthesized zeolite and creating a dry zeolite powder; calcining the dry zeolite powder creating a bimetal-containing lamellar MFI zeolite for chemical activation. |
| FILED | Tuesday, May 18, 2021 |
| APPL NO | 17/323448 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 29/76 (20130101) B01J 29/78 (20130101) Original (OR) Class B01J 35/026 (20130101) B01J 35/1057 (20130101) B01J 35/1061 (20130101) B01J 37/04 (20130101) B01J 37/06 (20130101) B01J 37/08 (20130101) B01J 37/009 (20130101) B01J 37/10 (20130101) B01J 37/0018 (20130101) B01J 37/30 (20130101) B01J 2229/26 (20130101) B01J 2229/183 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220371006 | Yager et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Paul Yager (Seattle, Washington); Steven Bennett (Seattle, Washington); Sujatha Kumar (Seattle, Washington); Kamal Girish Shah (Seattle, Washington); Erin K. Heiniger (Seattle, Washington) |
| ABSTRACT | An apparatus, system, and method for filtering and assaying a fluid sample are described. In an embodiment, the apparatus includes a filtration unit comprising: a filter bracket shaped to removably couple with a fluid sample cup and a vacuum container; and a filter housing cooperatively couplable to the filter bracket and comprising a filter configured to filter fluid passing through the filter bracket; and an assay device shaped to cooperatively couple with the filter housing and comprising a porous matrix positioned to be in fluidic communication with the filter when the filter housing is cooperatively coupled with the assay device. |
| FILED | Thursday, October 01, 2020 |
| APPL NO | 17/761138 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5023 (20130101) Original (OR) Class B01L 3/5635 (20130101) B01L 2300/042 (20130101) B01L 2300/0681 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/14 (20130101) G01N 2001/4088 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220371719 | Henry et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | U.S. Army DEVCOM Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Todd C. Henry (Aberdeen, Maryland); John T. Hrynuk (Joppa, Maryland); Christopher M. Kroninger (Wallingford, Pennsylvania); Michael R. Dorothy (Aberdeen, Maryland); Robert A. Haynes (Yorktown, Virginia) |
| ABSTRACT | A yaw alleviation device for an aircraft containing rotatable wing roots attached to wings. The device includes a spring configured to operatively connect to a wing; and a buckling member to operatively connect to the wing. The spring is configured to extend from an original unstrained position upon the buckling member undergoing buckling from an original unbuckled position to cause rotation of one or both wings in rotationally opposite directions. The buckling member may be positioned parallel and at an offset distance to the spring. |
| FILED | Friday, May 21, 2021 |
| APPL NO | 17/326911 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 3/40 (20130101) Original (OR) Class Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 25/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220371725 | Rubin |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America, as represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stuart H. Rubin (San Diego, California) |
| ABSTRACT | A vehicle includes a surface for contacting a fluid medium through which the vehicle is propelled. The vehicle also includes an array of transducers and a controller. The transducers in the array are arranged across the vehicle's surface for generating pressure waves in the fluid medium. Each transducer in the array is arranged to vibrate for generating a respective pressure wave, which propagates away from the surface in the fluid medium. The controller vibrates the transducers in the array so that the pressure waves control the drag of the vehicle from the fluid medium. |
| FILED | Tuesday, August 02, 2022 |
| APPL NO | 17/879128 |
| CURRENT CPC | Ships or Other Waterborne Vessels; Equipment for Shipping B63B 1/34 (20130101) Aeroplanes; Helicopters B64C 23/005 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220371750 | Garber et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Busek Co. Inc. (Natick, Massachusetts) |
| ASSIGNEE(S) | Busek Co. Inc. (Natick, Massachusetts) |
| INVENTOR(S) | Darren D. Garber (Rancho Palos Verdes, California); Vlad Hruby (Newton, Massachusetts); Andrew DeNucci (South Boston, Massachusetts); Matthew Averill (Charlestown, Massachusetts); Anthony Naccarato (Southborough, Massachusetts) |
| ABSTRACT | An apparatus includes a primary device, a secondary device, and an umbilical system. The umbilical system comprises an umbilical linking the primary device and the secondary device, and a control system configured alter a directionality of the umbilical during deployment of the secondary device away from the primary device by at least controlling a configuration of a shape memory material comprising the umbilical. |
| FILED | Thursday, May 19, 2022 |
| APPL NO | 17/748147 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/222 (20130101) Original (OR) Class B64G 1/646 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220371909 | Long et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Jeffrey W. Long (Alexandria, Virginia); Christopher N. Chervin (Washington, District of Columbia); Robert B. Balow (Mount Ranier, Maryland); Jeffrey C. Owrutsky (Silver Spring, Maryland); Debra R. Rolison (Arlington, Virginia); Kenan O. Fears (Alexandria, Virginia) |
| ABSTRACT | Disclosed is a method of decontamination by exposing a zirconium oxy(hydroxide) aerogel to a liquid, vapor, or gaseous sample suspected of containing a phosphonate compound. The aerogel may be doped with Fe3+ ions, Ce3+ ions, or SO42− ions. The aerogel may be made by: providing a solution of ZrCl4; FeCl3, CeCl3, or Zr(SO4)2; and a solvent; adding a cyclic ether to the solution to form a gel; infiltrating the gel with liquid carbon dioxide; applying a temperature and pressure to form supercritical fluid carbon dioxide; and removing the carbon dioxide for form an aerogel. |
| FILED | Thursday, August 04, 2022 |
| APPL NO | 17/817485 |
| CURRENT CPC | Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 25/02 (20130101) Original (OR) Class C01G 25/003 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2006/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220371946 | SHEIK-BAHAE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mansoor SHEIK-BAHAE (Albuquerque, New Mexico); Arash MAFI (Albuquerque, New Mexico); Mostafa PEYSOKHAN (Albuquerque, New Mexico); Esmaeil MOBINI SOUCHELMAEI (Albuquerque, New Mexico); Saeid ROSTAMI (Albuquerque, New Mexico) |
| ABSTRACT | A system, device, and method for laser cooling rare earth doped silica glass using anti-Stokes fluorescence is disclosed. The system includes a rare earth doped and codoped with one or more codopants silica glass; a laser that provides radiation to a first surface and through a body of the rare earth doped silica glass, wherein the laser is tuned from a first wavelength to a second wavelength; and a thermally sensitive device that captures images of the rare earth doped silica glass as the laser is tuned and determines a third wavelength between the first wavelength and the second wavelength where the rare earth doped silica glass is maximumly or near maximumly cooled. |
| FILED | Tuesday, October 20, 2020 |
| APPL NO | 17/770678 |
| CURRENT CPC | Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials C03C 13/045 (20130101) Original (OR) Class C03C 2201/36 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/176 (20130101) H01S 3/0408 (20130101) H01S 3/1618 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220371953 | Srubar, III et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| INVENTOR(S) | Wilfred V. Srubar, III (Boulder, Colorado); Sarah Lynn Williams (Boulder, Colorado); Jeffrey Cameron (Erie, Colorado); Mija Hubler (Boulder, Colorado); Sherri Cook (Boulder, Colorado); Aparna Nagarajan (Denver, Colorado); Chelsea Heveran (Denver, Colorado) |
| ABSTRACT | Methods of forming cement pastes, methods of forming concrete, and methods of forming other compositions using mineral particles formed from the one or more of biomineralizing microorganisms and biomineralizing microorganisms. Desired features, such as size and morphology, can be controlled by controlling growth parameters of the biomineralizing microorganisms and biomineralizing microorganisms. |
| FILED | Friday, October 30, 2020 |
| APPL NO | 17/773448 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 14/06 (20130101) C04B 14/08 (20130101) Original (OR) Class C04B 14/28 (20130101) C04B 28/04 (20130101) C04B 2103/0001 (20130101) Treatment of Inorganic Materials, Other Than Fibrous Fillers, to Enhance Their Pigmenting or Filling Properties; Preparation of Carbon Black; C09C 1/021 (20130101) C09C 1/3018 (20130101) C09C 1/3027 (20130101) C09C 3/006 (20130101) C09C 3/041 (20130101) C09C 3/043 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/12 (20130101) C12N 1/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372039 | Schiltz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gary E. Schiltz (Naperville, Illinois); Jindan Yu (Evanston, Illinois) |
| ABSTRACT | Disclosed are compounds that bind to embryonic ectoderm development (EED) protein and proteolysis-targeting chimeric (PROTAC) derivatives thereof that induce degradation of EED. The disclosed compounds may be characterized as substituted [1,2,4]triazolo[4,3-c]pyrimidin-5-amine compounds. The disclosed PROTAC derivatives thereof typically include a first targeting moiety that binds to EED (MEED) which may be derived from the disclosed [1,2,4]triazolo [4,3-c]pyrimidin-5-amine compounds that bind to EED. The first targeting moiety typically is linked via a bond or a linker (L) to a second targeting moiety that binds to an E3 ubiquitin ligase (ME3). As such, the disclosed PROTACS may be described as having a formula MEED-L-ME3 or ME3-L-MEED. |
| FILED | Friday, April 29, 2022 |
| APPL NO | 17/733752 |
| CURRENT CPC | Heterocyclic Compounds C07D 487/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372062 | Mirkin et al. |
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| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chad A. Mirkin (Wilmette, Illinois); Oliver G. Hayes (Evanston, Illinois); Benjamin Edward Partridge (Chicago, Illinois) |
| ABSTRACT | Provided herein are hierarchical protein structures comprising two or more proteins extending in one or more dimensions, the hierarchical protein structure comprising: a first protein comprising: (i) a patch A comprising one or more polynucleotides conjugated to the surface of the first protein; and (ii) a patch B comprising one or more polynucleotides conjugated to the surface of the first protein; and a second protein comprising: (i) a patch A′ comprising one or more polynucleotides conjugated to the surface of the second protein; and (ii) a patch B′ comprising one or more polynucleotides conjugated to the surface of the second protein; wherein the one or more polynucleotides of the patch A hybridizes to the one or more polynucleotides of the patch A′, and/or the one or more polynucleotides of the patch B hybridizes to the one or more polynucleotides of the patch B′ to form the hierarchical protein structure. Also provided are methods of making the hierarchical protein structures. |
| FILED | Tuesday, May 24, 2022 |
| APPL NO | 17/752407 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372077 | Pfeilsticker et al. |
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| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jessica A. Pfeilsticker (Pasadena, California); Aiko Umeda (Pasadena, California); James R Heath (Pasadena, California) |
| ABSTRACT | The present application provides stable peptide-based antibody capture agents and methods of use as detection and diagnosis agents. The application further provides methods of manufacturing antibody capture agents using iterative on-bead in situ click chemistry. |
| FILED | Monday, June 20, 2022 |
| APPL NO | 17/844509 |
| CURRENT CPC | Peptides C07K 7/08 (20130101) C07K 9/00 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56988 (20130101) G01N 2333/162 (20130101) G01N 2469/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372200 | GIANNESCHI et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | Northwestern University (Evanston, Illinois) |
| INVENTOR(S) | Nathan C. GIANNESCHI (Evanston, Illinois); Hao SUN (Evanston, Illinois) |
| ABSTRACT | Aspects of the invention include a method for synthesizing a peptide brush polymer, the method comprising: exposing a mixture comprising peptide-containing monomers, one or more photoinitiators, and one or more chain transfer agents to a light sufficient to induce photopolymerization, and photopolymerizing the peptide-containing monomers in the mixture; wherein: the resulting peptide brush polymer comprises at least one peptide-containing polymer block; the at least one peptide-containing polymer block is characterized by a degree of polymerization of at least 10 and a peptide graft density of 50% to 100%; and at least one peptide moiety of the at least one peptide-containing polymer block has 5 or more amino acid groups. |
| FILED | Tuesday, September 29, 2020 |
| APPL NO | 17/764746 |
| CURRENT CPC | Peptides C07K 1/1077 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 2/10 (20130101) C08F 2/50 (20130101) C08F 299/022 (20130101) Original (OR) Class C08F 2438/03 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372207 | Kriley et al. |
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| FUNDED BY |
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| APPLICANT(S) | PPG Industries Ohio, Inc. (Cleveland, Ohio) |
| ASSIGNEE(S) | PPG Industries Ohio, Inc. (Cleveland, Ohio) |
| INVENTOR(S) | Joseph P. Kriley (Valencia, Pennsylvania); Marvin M. Pollum, Jr. (Pittsburgh, Pennsylvania); Masayuki Nakajima (Wexford, Pennsylvania); David J. Fortman (Pittsburgh, Pennsylvania) |
| ABSTRACT | The present invention is directed to a curable composition including: an isocyanate-functional prepolymer; an epoxy-containing component present in an amount of at least 10 percent by weight of the composition; and a latent curing agent having an ability to react with at least one of the isocyanate-functional prepolymer and the epoxy-containing component upon exposure to an external energy source. The present invention is also directed to methods of making the compositions, methods of coating a substrate, methods of adhering substrates and coated substrates. |
| FILED | Wednesday, July 22, 2020 |
| APPL NO | 17/753976 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 5/022 (20130101) B32B 5/024 (20130101) B32B 5/26 (20130101) B32B 7/12 (20130101) B32B 15/00 (20130101) B32B 37/1207 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/10 (20130101) C08G 18/58 (20130101) Original (OR) Class C08G 18/755 (20130101) C08G 18/4854 (20130101) C08G 59/188 (20130101) C08G 59/4021 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 163/00 (20130101) C09D 175/04 (20130101) Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 163/00 (20130101) C09J 175/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372272 | ZHAO et al. |
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| FUNDED BY |
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| APPLICANT(S) | OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio); GEORGIA TECH RESEARCH CORPORATION (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ruike ZHAO (Columbus, Ohio); Xiao KUANG (Atlanta, Georgia); Hang QI (Atlanta, Georgia); Qiji ZE (Columbus, Ohio); Shuai WU (Columbus, Ohio) |
| ABSTRACT | Disclosed magnetic shape-memory compositions that comprise a polymer matrix and a population of hard-magnetic particles dispersed within the polymer matrix. In some embodiments, the magnetic shape-memory compositions can further comprise a population of auxiliary magnetic particles (e.g., ferrite particles) dispersed within the polymer matrix. The compositions can exhibit 1) reversible, fast, and controllable transforming deformation, 2) shape-locking, and 3) reprogramming capabilities. |
| FILED | Friday, June 19, 2020 |
| APPL NO | 17/621150 |
| CURRENT CPC | Compositions of Macromolecular Compounds C08L 63/00 (20130101) Original (OR) Class C08L 2201/12 (20130101) C08L 2203/02 (20130101) C08L 2207/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372423 | Ingber et al. |
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| FUNDED BY |
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| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Donald E. Ingber (Boston, Massachusetts); Daniel LEVNER (Boston, Massachusetts); Guy THOMPSON, III (Watertown, Massachusetts); Jose FERNANDEZ-ALCON (Cambridge, Massachusetts); Christopher David HINOJOSA (Cambridge, Massachusetts) |
| ABSTRACT | Systems and methods interconnect cell culture devices and/or fluidic devices by transferring discrete volumes of fluid between devices. A liquid-handling system collects a volume of fluid from at least one source device and deposits the fluid into at least one destination device. In some embodiments, a liquid-handling robot actuates the movement and operation of a fluid collection device in an automated manner to transfer the fluid between the at least one source device and the at least one destination device. In some cases, the at least one source device and the at least one destination device are cell culture devices. The at least one source device and the at least one destination device may be microfluidic or non-microfluidic devices. In some cases, the cell culture devices may be microfluidic cell culture devices. In further cases, the microfluidic cell culture devices may include organ-chips. |
| FILED | Friday, July 22, 2022 |
| APPL NO | 17/871054 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/0293 (20130101) B01L 3/502715 (20130101) B01L 2200/027 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) C12M 23/16 (20130101) C12M 23/38 (20130101) C12M 23/58 (20130101) C12M 29/00 (20130101) C12M 29/10 (20130101) Original (OR) Class C12M 29/20 (20130101) C12M 37/04 (20130101) C12M 41/48 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372585 | Moon et al. |
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| FUNDED BY |
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| APPLICANT(S) | Tae Seok Moon (St. Louis, Missouri); Hyojeong Yi (St. Louis, Missouri); Matthew Amrofell (St. Louis, Missouri); Chenggang Xi (St. Louis, Missouri); Austin Rottinghaus (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Tae Seok Moon (St. Louis, Missouri); Hyojeong Yi (St. Louis, Missouri); Matthew Amrofell (St. Louis, Missouri); Chenggang Xi (St. Louis, Missouri); Austin Rottinghaus (St. Louis, Missouri) |
| ABSTRACT | Among the various aspects of the present disclosure is the provision of molecular sensors, microbial sensors, constructs, systems, and methods for selectively detecting aromatic compounds. |
| FILED | Wednesday, April 27, 2022 |
| APPL NO | 17/731195 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/02 (20130101) C12Q 1/6897 (20130101) Original (OR) Class Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/19 (20210501) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/9406 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372887 | Dyer et al. |
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| FUNDED BY |
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| APPLICANT(S) | Raytheon Technologies Corporation (Farmington, Connecticut) |
| ASSIGNEE(S) | Raytheon Technologies Corporation (Farmington, Connecticut) |
| INVENTOR(S) | Timothy R. Dyer (North Haven, Connecticut); Abhijeet Shrestha (Newington, Connecticut) |
| ABSTRACT | A machine has: an outer member; an inner member mounted for rotation about an axis relative to the outer member; and a seal system. The seal system has: a seal housing mounted to the outer member; one or more seal rings held by the seal housing and having an inner diameter surface; and a seal runner mounted to the inner member and having a first outer diameter surface portion contacting or facing the inner diameter surface of the one or more seal rings. The seal runner has a circumferential array of mounting features. One or more weights are mounted to one or more of the mounting features. |
| FILED | Wednesday, August 03, 2022 |
| APPL NO | 17/880074 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/027 (20130101) F01D 11/003 (20130101) Original (OR) Class Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/28 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2230/60 (20130101) F05D 2240/55 (20130101) F05D 2260/15 (20130101) F05D 2260/30 (20130101) F05D 2300/226 (20130101) F05D 2300/611 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220373271 | Miljkovic et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nenad Miljkovic (Urbana, Illinois); Nithin Vinod Upot (Urbana, Illinois); Kazi Fazle Rabbi (Urbana, Illinois); Anthony M. Jacobi (Mahomet, Illinois); Allison J. Mahvi (Lakewood, Colorado) |
| ABSTRACT | A method of achieving high heat transfer during cooling includes providing an aluminum body having an inner surface enclosing a channel, where the inner surface comprises microscale roughness features and microcavities configured to enhance nucleation site density during flow boiling. A refrigerant is transported through the channel. During the transport, the refrigerant absorbs heat from a thermal load and undergoes flow boiling. The heat is transferred to the refrigerant at an average heat transfer coefficient of at least about 10 kW/(m2·K) at a mass flux of about 300 kg/(m2·s). |
| FILED | Wednesday, April 27, 2022 |
| APPL NO | 17/730502 |
| CURRENT CPC | Refrigeration Machines, Plants or Systems; Combined Heating and Refrigeration Systems; Heat-pump Systems F25B 9/006 (20130101) F25B 41/40 (20210101) Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 1/40 (20130101) Original (OR) Class F28F 21/084 (20130101) F28F 2260/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220373299 | Dwyer et al. |
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| FUNDED BY |
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| APPLICANT(S) | AimLock Inc. (Littleton, Colorado) |
| ASSIGNEE(S) | AimLock Inc. (Littleton, Colorado) |
| INVENTOR(S) | Benjamin Dwyer (Littleton, Colorado); Bryan Sterling Bockmon (Littleton, Colorado); Raymond Keeney (Littleton, Colorado); Jason R. Gallia (Littleton, Colorado); Shane Korthuis (Littleton, Colorado); Dusty Terry (Littleton, Colorado); Marc Hanchak (Littleton, Colorado) |
| ABSTRACT | A weapon mount for controlling targeting of a weapon includes a base, an arm that extends from the base, and an attachment component that is rotatably coupled with the arm. The base is attachable to a platform and is rotatable to control a yaw of the weapon relative to the platform. The attachment component is configured to couple with the weapon and is rotatable to control a pitch of the weapon relative to the platform. The arm is positioned relative to the base so that a recoil vector of the weapon is within 0.5 inches radially of an axis of rotation of the base. |
| FILED | Friday, March 11, 2022 |
| APPL NO | 17/693091 |
| CURRENT CPC | Functional Features or Details Common to Both Smallarms and Ordnance, e.g Cannons; Mountings for Smallarms or Ordnance F41A 23/06 (20130101) F41A 23/52 (20130101) Weapon Sights; Aiming F41G 3/165 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220373325 | Ferro et al. |
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| FUNDED BY |
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| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Frank Ferro (West Chester, Ohio); Peter Coomes (Middletown, Ohio) |
| ABSTRACT | A system for imaging a component defining a negative space is provided comprising a component imaging assembly, a bolus insert, and an imaging device. The bolus insert is positionable in the component's negative space when the component is positioned within an imaging device imaging field to produce a component image. A method is provided comprising positioning a bolus insert within a component's negative space and scanning the component having the bolus insert to create an image of the component. A component imaging assembly is provided comprising a component including a first portion having a first thickness that is greater than a second thickness of a second portion; and a bolus insert positioned adjacent the second portion that has a bolus thickness substantially similar to a difference between the first and second thicknesses. The bolus insert has a bolus material density within fifteen percent (15%) of a component material density. |
| FILED | Friday, May 21, 2021 |
| APPL NO | 17/326778 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 15/04 (20130101) Original (OR) Class Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 13/00 (20130101) G01M 15/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220373395 | Wilson et al. |
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| FUNDED BY |
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| APPLICANT(S) | U.S. Army Combat Capabilities Development Command, Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam A. Wilson (Columbia, Maryland); Dennis L. Waldron (Chesapeake Beach, Maryland); Cory R. Knick (Troy, Ohio); Darin J. Sharar (Silver Spring, Maryland) |
| ABSTRACT | Sensor interconnects and supports and methods of making them utilize phonon disruptors for increased thermal resistance while maintaining acceptable electrical signal quality in materials. Phonon disruptors include the use of an electrically conductive alloy material or intermetallic material of at least two or more elements to promote scattering of phonons. These materials are selected to scatter heat carriers while allowing electrons to pass through the material. |
| FILED | Tuesday, May 10, 2022 |
| APPL NO | 17/741185 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 5/20 (20130101) Original (OR) Class G01J 2005/0077 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220373409 | Kolacz et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jakub Kolacz (Washington, District of Columbia); Peter Finkel (Washington, District of Columbia); Julia Pavlova (Washington, District of Columbia); Christopher M. Spillmann (Washington, District of Columbia) |
| ABSTRACT | Piezo-optic transducers convert variations in mechanical stress to a change in optical properties by coupling electro-optic and piezo-electric elements in a format suited to a single composite device without needing on-board electronics. |
| FILED | Tuesday, May 03, 2022 |
| APPL NO | 17/735613 |
| CURRENT CPC | Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/16 (20130101) Original (OR) Class Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/11 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 41/1132 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220373458 | YOUSSEF et al. |
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| FUNDED BY |
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| APPLICANT(S) | San Diego State University (SDSU) Fourndation, dba San Diego State University Research Foundation (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George YOUSSEF (Solana Beach, California); Nha Uyen HUYNH (La Jolla, California) |
| ABSTRACT | A testing apparatus for dynamic characterization of a sample of a material under test. A terahertz (THz) time-domain spectroscopy system is configured and arranged to generate and detect terahertz waves to interrogate the sample. A shock wave loading system is configured and arranged to produce a shock wave in the sample concurrently with said THz spectroscopy device interrogating the sample. The sample undergoes changes in an index of refraction in response to the produced ultrafast shock wave in the sample that are detected by the terahertz spectroscopy system. |
| FILED | Friday, October 30, 2020 |
| APPL NO | 17/770277 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/41 (20130101) G01N 21/3586 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220373463 | KELLEY et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTH CAROLINA (COLUMBIA, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | MATHEW L. KELLEY (COLUMBIA, South Carolina); ANDREW B. GREYTAK (COLUMBIA, South Carolina); MVS CHANDRASHEKHAR (COLUMBIA, South Carolina) |
| ABSTRACT | Spatially resolved Fourier Transform Impedance Spectroscopy (FTIS) is disclosed to spatially map and quickly build the frequency response of optoelectronic devices using optical probes. The transfer function of a linear system is the Fourier transform of its impulse response, which may be obtained from transient photocurrent measurements of devices such as photodetectors and solar cells. We apply FTIS to a PbS colloidal quantum dot (QD)/SiC heterojunction photodiode and corroborate results using intensity-modulated photocurrent spectroscopy. The cutoff frequencies of the QD/SiC devices were as high as ˜10 kHz, demonstrating their utility in advanced flexible and thin film electronics. The practical frequencies for FTIS lie in the mHz-kHz range, ideal for composite or novel materials such as QD films that are dominated by interfacial trap states. |
| FILED | Monday, March 07, 2022 |
| APPL NO | 17/688230 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6452 (20130101) Original (OR) Class G01N 21/6456 (20130101) G01N 2021/6423 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220373473 | Steffan et al. |
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| FUNDED BY |
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| APPLICANT(S) | NOVI LLC (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott Steffan (Hamburg, New York); Constantine Papageorgiou (Needham, Massachusetts); Amit Mehra (Arlington, Virginia) |
| ABSTRACT | A system for taking high-resolution photographs from a vehicle-mounted camera, forming orthomosaics from video and/or multiple high-resolution photographs, and using artificial intelligence to detect and classify pavement flaws and defects in the imagery. Detection also includes the ability to capture quantifiable metrics for the defects and/or a region of interest. Three-dimensional imagery is produced from the same images as the orthomosaics. Surface and terrain map products made from the same source images capture additional details such as depth and volume. The highlighted orthomosaics and three-dimensional imagery can then be used as a basis to determine the pavement surface condition and subsequently support maintenance orders and manage pavement repairs. Further, metadata such as latitude, longitude, and altitude geo-location coordinates and sampling time can also be transferred to the output products to create a digital time history and enable analysis for preventative maintenance planning. Alternatively-sourced imagery may also be analyzed. |
| FILED | Monday, October 04, 2021 |
| APPL NO | 17/493342 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/8851 (20130101) Original (OR) Class G01N 2021/888 (20130101) G01N 2021/889 (20130101) G01N 2021/8861 (20130101) G01N 2021/8874 (20130101) G01N 2021/8877 (20130101) Image Data Processing or Generation, in General G06T 7/0002 (20130101) G06T 2207/10004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220373529 | Seifu |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Morgan State University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dereje Seifu (Towson, Maryland) |
| ABSTRACT | Sensor and method for detecting, monitoring and/or removing trace amounts of heavy metal in a liquid. The sensor including magnetic nanoparticle composites of carbon nanotubes intercalated with CoFe2O4; the method including contacting a sample of liquid with the magnetic nanoparticle composites and measuring the X-ray diffraction and magnetic properties of the magnetic nanoparticle composite, where a statistical difference in the X-ray diffraction or magnetic properties of the magnetic nanoparticle composite before and after contact between said sample of said liquid and said magnetic nanoparticle composite indicates the presence of a heavy metal in said liquid. |
| FILED | Friday, April 29, 2022 |
| APPL NO | 17/732975 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/62 (20130101) C02F 1/288 (20130101) C02F 2101/22 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/085 (20180201) G01N 23/202 (20130101) G01N 33/1813 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220373537 | XU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts); THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts); THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts) |
| INVENTOR(S) | Ke XU (Cambridge, Massachusetts); Marc E. LENBURG (Brookline, Massachusetts); Ehab BILLATOS (Milton, Massachusetts); Alejandro A. DIAZ (Boston, Massachusetts) |
| ABSTRACT | Described herein are methods relating to the diagnosis, prognosis, and treatment of airway dysfunction, e.g., bronchiectasis by detecting gene expression in a sample obtained from a subject. Exemplary samples include a bronchial brushing, nasal brushing, sputum, or peripheral blood sample. |
| FILED | Thursday, May 19, 2022 |
| APPL NO | 17/748404 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 2539/10 (20130101) C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5023 (20130101) Original (OR) Class G01N 2800/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220373543 | Gopinath et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ashwin Gopinath (Pasadena, California); Paul W.K. Rothemund (Pasadena, California) |
| ABSTRACT | Bistable devices are constructed using a polynucleotide platform for sensing molecular events such as binding or conformational changes of target molecules. Uses include measurement of target concentration, measuring the effect of environmental condition (such as heat, light, or pH) on the target, or screening a library for molecules that bind the target or modulate its biological function. Devices comprise three regions: a top lid, bottom lid, and flexible linker or hinge between them. A device has an open configuration in which the top and bottom lid are separated, and a closed configuration they are bound close together. Binding domains or variations of the target molecule are fixed to a device so that when the molecular event occurs, the device switches from open to closed, or vice versa, which generates a signal. Optimal device design is determined by the signal modality (optical or electronic) used to measure closure of surface-immobilized devices. |
| FILED | Thursday, June 02, 2022 |
| APPL NO | 17/830901 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) C12N 2310/20 (20170501) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/47 (20130101) G01N 21/553 (20130101) G01N 21/6428 (20130101) G01N 33/544 (20130101) G01N 33/54373 (20130101) Original (OR) Class G01N 2021/6439 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220373735 | Safavi-Naeini et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amir H. Safavi-Naeini (Palo Alto, California); Timothy Patrick McKenna (San Francisco, California); Hubert S. Stokowski (Stanford, California) |
| ABSTRACT | In an integrated optical device, squeezed light is used internally to effectively increase an optical modulation effect. One exemplary device operates by squeezing the light at the input, then sending it through an electro-optic stage where its phase picks up the signal of interest, and finally anti-squeezing it to obtain a displaced coherent state. Thus the displacement is amplified by the level of squeezing that is achieved inside the device and it is thereby less sensitive to loss. Since this device behaves simply as an electro-optic modulator, albeit one with an exponentially enhanced sensitivity, no extra considerations are needed to integrate the modulator into a system. Such devices can be operated as modulators or as sensors, and can make use of optical phase shift effects other than the electro-optic effect. |
| FILED | Monday, May 09, 2022 |
| APPL NO | 17/740027 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/12004 (20130101) Original (OR) Class G02B 6/12007 (20130101) G02B 6/29344 (20130101) G02B 2006/1204 (20130101) G02B 2006/12138 (20130101) G02B 2006/12142 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220373747 | Galvan |
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| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Jaime Galvan (Bloomington, Indiana) |
| ABSTRACT | Provided is a secure quick communication system disconnect switch box that enables remote verification of communication path connection or disconnection status. The box utilizes a lid having an affixed jumper circuit/assembly bridging or coupling at least two network connections. When the lid to the switch box is attached, the at least two computers/networks are connected via the jumper circuit/assembly. When the lid is removed from the switch box, the jumper circuit/assembly is disconnected from the at least two computer/networks, thereby disconnecting and isolating the otherwise coupled computers/networks. Removal of the lid additionally exposes network maintenance/access ports to provide access to one or more of the computers/network. When the lid is closed, the network maintenance/access ports are inaccessible to the user. |
| FILED | Tuesday, May 17, 2022 |
| APPL NO | 17/746222 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/3834 (20130101) G02B 6/3897 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220373751 | MAITI et al. |
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| FUNDED BY |
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| APPLICANT(S) | The George Washington University (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rishi MAITI (Washington, District of Columbia); Volker SORGER (Alexandria, Virginia) |
| ABSTRACT | A photonic device that includes two electrodes and a two-dimensional (2D) material electrically connecting the two electrodes. The 2D material may be molybdenum ditelluride. Strain may be induced in the 2D material (e.g., by placing the 2D material on a waveguide) to reduce the band gap of the 2D material and increase the efficiency of the photodetector. The photonic device may be a photodetector with 2D material that absorbs light energy and converts it into a photocurrent in a circuit that includes the two electrodes. The photonic device may be an emitter with 2D material that emits light energy in response to an electric field across the two electrodes. The photonic device may be a modulator with 2D material that modulates a property of an optical signal (e.g., the amplitude or phase) by modulating the amount of strain induced in the 2D material. |
| FILED | Friday, November 20, 2020 |
| APPL NO | 17/771763 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/4295 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220373763 | Paranto et al. |
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| FUNDED BY |
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| APPLICANT(S) | Applied Research Associates, Inc. (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph N. Paranto (Albuquerque, New Mexico); Michael E. Meline (Albuquerque, New Mexico); Devin M.J. Todd (Orlando, Florida); Matthew Flint Kepler (Austin, Texas); Martin William Slack (Edgewood, New Mexico) |
| ABSTRACT | Configurations and compositions for frameworks supporting optics such as lenses are described that provide an invariant structure regardless of temperature swings, thereby maintaining alignment and focus. Frameworks may comprise tiered structures of materials having multiple distinct coefficients of thermal expansion. An optical framework includes a first framework portion coupled to a first lens and a second framework portion coupled to a second lens. The first framework portion and second framework portion comprise materials having a coefficient of thermal expansion such that expansion of the first framework portion in one direction is offset by expansion of the second framework portion in an opposite direction. |
| FILED | Thursday, May 20, 2021 |
| APPL NO | 17/325982 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 7/008 (20130101) G02B 7/021 (20130101) G02B 7/028 (20130101) Original (OR) Class Pictorial Communication, e.g Television H04N 5/2254 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20220373789 — FOCUSING DEVICE COMPRISING A PLURALITY OF SCATTERERS AND BEAM SCANNER AND SCOPE DEVICE
| US 20220373789 | ARBABI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Samsung Electronics Co., Ltd. (Suwon-si, South Korea); California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | Samsung Electronics Co., Ltd. (Suwon-si, South Korea); California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Amir ARBABI (Pasadena, California); Seunghoon Han (Seoul, South Korea); Andrei Faraon (Pasadena, California) |
| ABSTRACT | A focusing device includes a substrate and a plurality of scatterers provided at both sides of the substrate. The scatterers on the both sides of the focusing device may correct geometric aberration, and thus, a field of view (FOV) of the focusing device may be widened. |
| FILED | Tuesday, July 26, 2022 |
| APPL NO | 17/874004 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 3/0087 (20130101) G02B 5/0263 (20130101) G02B 5/0294 (20130101) G02B 5/1876 (20130101) G02B 5/3083 (20130101) G02B 23/00 (20130101) G02B 27/005 (20130101) G02B 27/0031 (20130101) Original (OR) Class G02B 27/0927 (20130101) G02B 27/0955 (20130101) G02B 27/4216 (20130101) G02B 27/4272 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220373855 | Yousefzadeh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Kent State University (Kent, Ohio); Government of the United States as Represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | Kent State University (Kent, Ohio); Government of the United States as Represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| INVENTOR(S) | Comrun Yousefzadeh (Kent, Ohio); Philip Bos (Hudson, Ohio); Andre Van Rynbach (Dayton, Ohio) |
| ABSTRACT | Optical phase control elements are based on the Pancharatnam phase. Tunable liquid crystal devices containing the optical phase control elements may include a liquid crystal cell between a pair of substrates, a first plurality of electrodes, and a second plurality of electrodes. Each individual phase control element is defined by one electrode from the first plurality and one electrode from the second plurality. |
| FILED | Tuesday, February 22, 2022 |
| APPL NO | 17/651925 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/4817 (20130101) Optical Elements, Systems, or Apparatus G02B 26/08 (20130101) G02B 27/283 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/29 (20130101) Original (OR) Class G02F 2203/24 (20130101) G02F 2203/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220374234 | Imani |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mohsen Imani (Irvine, California) |
| ABSTRACT | Stochastic hyperdimensional arithmetic computing is provided. Hyperdimensional computing (HDC) is a neurally-inspired computation model working based on the observation that the human brain operates on high-dimensional representations of data, called hypervectors. Although HDC is powerful in reasoning and association of the abstract information, it is weak on feature extraction from complex data. Consequently, most existing HDC solutions rely on expensive pre-processing algorithms for feature extraction. This disclosure proposes StocHD, a novel end-to-end hyperdimensional system that supports accurate, efficient, and robust learning over raw data. StocHD expands HDC functionality to the computing area by mathematically defining stochastic arithmetic over HDC hypervectors. StocHD enables an entire learning application (including feature extractor) to process using HDC data representation, enabling uniform, efficient, robust, and highly parallel computation. This disclosure further provides a novel fully digital and scalable processing in-memory (PIM) architecture that exploits the HDC memory-centric nature to support extensively parallel computation. |
| FILED | Friday, May 13, 2022 |
| APPL NO | 17/744371 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/3001 (20130101) G06F 9/3555 (20130101) G06F 9/30036 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220374403 | WANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NVIDIA CORPORATION (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hanrui WANG (Cambridge, Massachusetts); James Michael O'CONNOR (Austin, Texas); Donghyuk LEE (Cedar Park, Texas) |
| ABSTRACT | One embodiment sets forth a technique for generating a tree structure within a computer memory for storing sparse data. The technique includes dividing a matrix into a first plurality of equally sized regions. The technique also includes dividing at least one region in the first plurality of regions into a second plurality of regions, where the second plurality of regions includes a first region and one or more second regions that have a substantially equal number of nonzero matrix values and are formed within the first region. The technique further includes creating the tree structure within the computer memory by generating a first plurality of nodes representing the first plurality of regions, generating a second plurality of nodes representing the second plurality of regions, and grouping, under a first node representing the first region, one or more second nodes representing the one or more second regions. |
| FILED | Wednesday, May 19, 2021 |
| APPL NO | 17/325133 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/2237 (20190101) Original (OR) Class G06F 16/2246 (20190101) G06F 16/2272 (20190101) G06F 17/16 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6244 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220374496 | WANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NVIDIA CORPORATION (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hanrui WANG (Cambridge, Massachusetts); James Michael O'CONNOR (Austin, Texas); Donghyuk LEE (Cedar Park, Texas) |
| ABSTRACT | One embodiment sets forth a technique for performing one or more matrix multiplication operations based on a first matrix and a second matrix. The technique includes receiving data associated with the first matrix from a first traversal engine that accesses nonzero elements included in the first matrix via a first tree structure. The technique also includes performing one or more computations on the data associated with the first matrix and the data associated with the second matrix to produce a plurality of partial results. The technique further includes combining the plurality of partial results into one or more intermediate results and storing the one or more intermediate results in a first buffer memory. |
| FILED | Wednesday, May 19, 2021 |
| APPL NO | 17/325120 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/5072 (20130101) G06F 16/9027 (20190101) G06F 17/16 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220374606 | Mosallanezhad et al. |
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| FUNDED BY |
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| APPLICANT(S) | Ahmadreza Mosallanezhad (Tempe, Arizona); Ghazaleh Beigi (Tempe, Arizona); Huan Liu (Tempe, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on Behalf of Arizona State University (Tempe, Arizona) |
| INVENTOR(S) | Ahmadreza Mosallanezhad (Tempe, Arizona); Ghazaleh Beigi (Tempe, Arizona); Huan Liu (Tempe, Arizona) |
| ABSTRACT | Various embodiments of a system and associated method for anonymization of text without losing semantic utility of text by extracting a latent embedding representation of content with respect to a given task and by learning an optimal strategy for text embedding manipulation to satisfy both privacy and utility requirements are disclosed herein. In particular, the system balances private attribute obfuscation with retained semantic utility. |
| FILED | Tuesday, November 16, 2021 |
| APPL NO | 17/527632 |
| CURRENT CPC | Electric Digital Data Processing G06F 40/30 (20200101) Original (OR) Class Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6262 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220374679 | Bazhenov et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Maksim Bazhenov (San Diego, California); Giri Prashanth Krishnan (San Diego, California); Timothy Tadros (San Diego, California) |
| ABSTRACT | Systems and methods for generating Artificial Neural Networks (ANNs) based on the principles of biological sleep are disclosed. Namely, the systems and methods can be configured to apply a sleep-like phase to ANNs which enables training to be generalized, performance to be improved, and catastrophic forgetting for sequential multi-task training to be prevented. Various implementations of these systems and methods can be configured to: (i) train an ANN using backpropagation algorithm, (ii) convert the architecture of the ANN to an equivalent Spiking Neural Network (SNN) and simulate a sleep phase in the SNN while using plasticity rules to modify synaptic weights, and (iii) convert the modified synaptic weights associated with the simulated sleep phase of the SNN back into the ANN. This transformation from ANN to SNN to ANN effectively emulates learning mechanisms actuated during biological sleep and, as such, overcomes limitations commonly associated with machine learning. |
| FILED | Friday, July 17, 2020 |
| APPL NO | 17/627092 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/049 (20130101) Original (OR) Class G06N 3/084 (20130101) G06N 3/0481 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220374759 | Barnes et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (Blacksburg, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edwin Barnes (Blacksburg, Virginia); Junkai Zeng (Blacksburg, Virginia) |
| ABSTRACT | Aspects of generating error-resistant quantum control pulses from geometrical curves are described. In some embodiments, a closed space curve is parameterized for a target gate operation of a quantum computing device. The closed space curve corresponds to an evolution operator of a time-dependent Schrödinger equation associated with the target gate operation. A control field definition is identified for the target gate operation based at least in part on a geometrical analysis of the evolution operator of the time-dependent Schrödinger equation. The target gate operation is implemented for the quantum computing device based on the control field definition. |
| FILED | Friday, October 02, 2020 |
| APPL NO | 17/765875 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/60 (20220101) Original (OR) Class Pulse Technique H03K 17/92 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220374961 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NVIDIA CORPORATION (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hanrui Wang (Cambridge, Massachusetts); James Michael O'Connor (Austin, Texas); Donghyuk Lee (Cedar Park, Texas) |
| ABSTRACT | One embodiment sets forth a technique for performing matrix operations. The technique includes traversing a tree structure to access one or more non-empty regions within a matrix. The tree structure includes a first plurality of nodes and a second plurality of nodes corresponding to non-empty regions in the matrix. The first plurality of nodes includes a first node representing a first region and one or more second nodes that are children of the first node and represent second region(s) with an equal size formed within the first region. The second plurality of nodes include a third node representing a third region and one or more fourth nodes that are children of the third node and represent fourth region(s) with substantially equal numbers of non-zero matrix values formed within the third region. The technique also includes performing matrix operation(s) based on the non-empty region(s) to generate a matrix operation result. |
| FILED | Wednesday, May 19, 2021 |
| APPL NO | 17/325116 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/9027 (20190101) G06F 17/16 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 30/0631 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220375034 | Bashkansky et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Mark Bashkansky (Alexandria, Virginia); Samuel Park (McLean, Virginia); John F. Reintjes (Alexandria, Virginia) |
| ABSTRACT | A method for using a single-pixel camera to reconstruct images of objects obscured by fog or other dynamic scattering media. A pseudo-random phase or intensity pattern is imposed on illumination beams directed at a target. The beam with the imposed pattern forms a pseudo random pattern on the target. Information regarding the pattern imposed on each pulse is entered into a data processor/controller. The illumination beams with the pseudo random patterns are reflected off the target, collected by receiving optics and a bucket detector and converted into electronic signals fed into the data processor/controller. The data processor/controller applies a high-pass filter to remove slower signal variations produced by dynamic changes in the scattering medium over time. The filtered bucket values are then used together with their corresponding speckle patterns to generate the images using any appropriate reconstruction algorithm such as CGI or CSI. |
| FILED | Thursday, March 10, 2022 |
| APPL NO | 17/691172 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 5/001 (20130101) Original (OR) Class G06T 5/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220375102 | Grauman et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kristen Grauman (Austin, Texas); Suyog Dutt Jain (Boston, Massachusetts); Bo Xiong (Austin, Texas) |
| ABSTRACT | A method, system and computer program product for segmenting generic foreground objects in images and videos. For segmenting generic foreground objects in videos, an appearance stream of an image in a video frame is processed using a first deep neural network. Furthermore, a motion stream of an optical flow image in the video frame is processed using a second deep neural network. The appearance and motion streams are then joined to combine complementary appearance and motion information to perform segmentation of generic objects in the video frame. Generic foreground objects are segmented in images by training a convolutional deep neural network to estimate a likelihood that a pixel in an image belongs to a foreground object. After receiving the image, the likelihood that the pixel in the image is part of the foreground object as opposed to background is then determined using the trained convolutional deep neural network. |
| FILED | Tuesday, August 02, 2022 |
| APPL NO | 17/879124 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/0454 (20130101) Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/143 (20170101) G06T 7/194 (20170101) Original (OR) Class G06T 7/215 (20170101) G06T 2207/10016 (20130101) G06T 2207/20076 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) Image or Video Recognition or Understanding G06V 10/82 (20220101) G06V 20/49 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220375214 | Caulfield et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cyan Systems (Santa Barbara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Caulfield (Santa Barbara, California); Jon Paul Curzan (Arroyo Grande, California); Kenton Veeder (Goleta, California) |
| ABSTRACT | A mechanism for radiation detection is disclosed. An integrated circuit usable in detecting radiation includes a plurality of readout circuits is described. A readout circuit of the plurality of readout circuits includes an integration capacitor and an averaging capacitor. The integration capacitor is coupled with a pixel of a photodetector pixel array. The pixel has a pixel area. An available area less than the pixel area is usable for layout of the integration capacitor. The integration capacitor has a capacitor area less than the available area. The averaging capacitor has an averaging capacitance greater than the integration capacitance of the integration capacitor. In some aspects, the integrated circuit further includes at least one cascaded averaging circuit coupled with the averaging capacitor. |
| FILED | Thursday, July 28, 2022 |
| APPL NO | 17/876265 |
| CURRENT CPC | Image or Video Recognition or Understanding G06V 10/94 (20220101) Original (OR) Class G06V 10/7515 (20220101) Pictorial Communication, e.g Television H04N 5/33 (20130101) H04N 5/341 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220375237 | LIU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| ASSIGNEE(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| INVENTOR(S) | Xiaoming LIU (Okemos, Michigan); Abhinav KUMAR (East Lansing, Michigan); Garrick BRAZIL (East Lansing, Michigan) |
| ABSTRACT | An end-to-end trainable grouped mathematically differentiable non-maximal suppression (NMS) technique is presented for monocular 3D object detection. First, formulate NMS as a matrix operation and then group and mask the boxes in an unsupervised manner to obtain a simple closed-form expression of the NMS. This technique addresses the mismatch between training and inference pipelines and, therefore, forces the network to select the best 3D box in a differentiable manner. As a result, the proposed technique achieves state-of-the-art monocular 3D object detection results on the KITTI benchmark dataset performing comparably to monocular video-based methods. |
| FILED | Tuesday, February 22, 2022 |
| APPL NO | 17/677193 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/73 (20170101) Image or Video Recognition or Understanding G06V 10/26 (20220101) G06V 10/82 (20220101) G06V 10/763 (20220101) G06V 10/764 (20220101) G06V 10/776 (20220101) G06V 20/64 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220375754 | Taylor et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | U.S. Army DEVCOM, Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Patrick J. Taylor (Oakton, Virginia); George J. de Coster (Vienna, Virginia) |
| ABSTRACT | A topological material includes a lattice crystalline structure; and a material defect in the lattice crystalline structure that is treatable by hydrogen passivation that chemically mitigates an electronic charge associated with the material defect. The lattice crystalline structure includes dangling bonds in an atomic arrangement of the material defect of the lattice crystalline structure, and the hydrogen passivation may apply hydrogen to chemically passivate the dangling bonds of the material defect. The hydrogen passivation may be achieved by diffusing hydrogen into common materials of the lattice crystalline structure. The hydrogen passivation may chemically and/or electrostatically neutralize an electronic activity associated with the material defect. |
| FILED | Tuesday, May 18, 2021 |
| APPL NO | 17/323305 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/3003 (20130101) Original (OR) Class H01L 29/04 (20130101) H01L 43/02 (20130101) H01L 43/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220376105 | Guo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wolfspeed, Inc. (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jia Guo (Apex, North Carolina); Saptharishi Sriram (Cary, North Carolina); Scott Sheppard (Chapel Hill, North Carolina) |
| ABSTRACT | A transistor device according to some embodiments includes a channel layer, a barrier layer on the channel layer, and source and drain contacts on the barrier layer, and a gate contact on the barrier layer between the source and drain contacts. The channel layer includes a sub-layer having an increased doping concentration level relative to a remaining portion of the channel layer. The presence of the sub-layer may reduce drain lag without substantially increasing gate lag. |
| FILED | Thursday, May 20, 2021 |
| APPL NO | 17/325610 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/765 (20130101) H01L 21/7605 (20130101) H01L 29/404 (20130101) H01L 29/2003 (20130101) H01L 29/7787 (20130101) Original (OR) Class H01L 29/66462 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220376157 | Fish |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | U.S. Army DEVCOM, Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael C. Fish (Arlington, Virginia) |
| ABSTRACT | A thermal energy storage (TES) device includes a thermoelectric cooler; and a metallic phase change material (PCM) within the thermoelectric cooler. The PCM may include any of gallium or its alloys, low temperature fusible alloys, and solid metal shape memory alloys. A thermoelectric effect within the PCM is to transport heat in the thermoelectric cooler. The TES device may include a graded oxide layer adjacent to the PCM to serve as a distributed electrical junction in the thermoelectric cooler to create a hot side thermoelectric junction in a bulk volume of the PCM. The graded oxide layer may include α-IGZO. The TES device may include a high-thermopower corrugated metal foil layer comprising barrier oxides patterned therein. The high-thermopower metal foil layer may be adjacent to the graded oxide layer. The TES device may include a dielectric layer adjacent to the high-thermopower corrugated metal foil layer. |
| FILED | Thursday, December 09, 2021 |
| APPL NO | 17/546246 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 35/30 (20130101) Original (OR) Class H01L 35/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220376315 | Hammond et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Christopher J. Hammond (Bloomington, Indiana); Alexander M. Potter (Bloomington, Indiana) |
| ABSTRACT | Provided is a battery grid pellet adhesion/cohesion strength tester that can accurately determine the push-out strength of a battery grid pellet by measuring the binding of the active material to the battery grid during the pasting and curing process. A programmable test stand and force gage are used with a selectable active material punching tool fixture and a set of selectable set of grid location pins. Active material from a lead-acid battery is forced out of the battery grid at a programmed feed rate with the force gage reporting precise force measurements for each battery grid pellets adhesion/cohesion strength. The inventive device can be utilized as a quality control measure following the battery pasting and curing process, which will ensure that consistent and uniform adhesion/cohesion has occurred during battery manufacture, thereby avoiding battery premature performance failure. |
| FILED | Wednesday, May 18, 2022 |
| APPL NO | 17/747267 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 19/04 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/4285 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220376725 | MEDARD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); National University of Ireland, Maynooth (Maynooth, Ireland) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); National University of Ireland, Maynooth (Maynooth, Ireland) |
| INVENTOR(S) | Muriel MEDARD (Belmont, Massachusetts); Kenneth R. DUFFY (Burke, Virginia); Amit SOLOMON (Cambridge, Massachusetts); Alejandro COHEN (Brookline, Massachusetts) |
| ABSTRACT | Described are concepts, systems, devices and methods that enhance decoding performance of channels subject to correlated noise. The concepts, systems, devices and methods can be used with any combination of codes, code-rates and decoding techniques. In embodiments, a continuous realization of effective noise is estimated from a lead channel by subtracting its decoded output from its received signal. This estimate is then used to improve the accuracy of decoding of an otherwise orthogonal channel that is experiencing correlated effective noise. In this approach, channels aid each other through the post-decoding provision of estimates of effective noise. In some embodiments, the lead channel is not pre-determined, but is chosen dynamically based on which of a plurality of decoders completes first, or using soft information including an estimate of effective noise that is least energetic or most likely to have occurred. |
| FILED | Friday, July 22, 2022 |
| APPL NO | 17/814349 |
| CURRENT CPC | Transmission H04B 1/123 (20130101) Original (OR) Class H04B 1/1027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220376821 | Hunter |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Aerospace Corporation (El Segundo, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Thomas Hunter (Ashburn, Virginia) |
| ABSTRACT | System and methods are disclosed that comprise receiving at least one signal via a receiver. The at least one signal is extracted for data via a processor coupled to the receiver, wherein the data includes at least one message and a set of parameters related to the message. A signal output is generated using the at least one message and the set of parameters such that the signal output includes a first portion and a second portion. At least one error is identified in the signal output and corrected using the first portion and the second portion. An output is generated that is used to perform at least one task related to the at least one signal. |
| FILED | Friday, May 21, 2021 |
| APPL NO | 17/327493 |
| CURRENT CPC | Coding; Decoding; Code Conversion in General H03M 13/2957 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 1/0005 (20130101) H04L 1/0055 (20130101) Original (OR) Class Wireless Communication Networks H04W 4/90 (20180201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220377084 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fan Zhang (New York, New York); Sai Krishna Deepak Maram (New York, New York); Harjasleen Malvai (Ithaca, New York); Steven Goldfeder (Spring Valley, New York); Ari Juels (New York, New York) |
| ABSTRACT | A verifier device in one embodiment is configured to communicate over one or more networks with a client device and a server device. The verifier device participates in a three-party handshake protocol with the client device and the server device in which the verifier device and the client device obtain respective shares of a session key of a secure session with the server device. The verifier device receives from the client device a commitment relating to the secure session with the server device, and responsive to receipt of the commitment, releases to the client device additional information relating to the secure session that was not previously accessible to the client device. The verifier device verifies correctness of at least one characterization of data obtained by the client device from the server device as part of the secure session, based at least in part on the commitment and the additional information. |
| FILED | Friday, August 28, 2020 |
| APPL NO | 17/636402 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 63/126 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20220370086 | Szafron et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California); The Texas A and M University System (College Statin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason Szafron (Hamden, Connecticut); Duncan Maitland (College Station, Texas); Ward Small, IV (Livermore, California); Patrick R. Buckley (Livermore, California); Andrea D. Muschenborn (Bloomington, Indiana) |
| ABSTRACT | An embolectomy device comprised of an expansion unit and a support unit is disclosed. The expansion unit can be actuated in response to one or more external stimuli, and the support unit, located proximately to the expansion unit, provides a force to hold the expansion unit in place and to further induce the expansion unit's radial expansion. The radial expansion of the expansion unit causes the expansion unit to physically contact a blood clot, enabling the blood clot to be removed. In some embodiments, the expansion unit can be fabricated from a shape memory polymer foam. In some embodiments the support unit can be fabricated from any elastic material including, without limitation, shape memory alloys. |
| FILED | Friday, August 05, 2022 |
| APPL NO | 17/881684 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/22 (20130101) Original (OR) Class A61B 2017/2212 (20130101) A61B 2017/22094 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370960 | Nair et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sankar Nair (Atlanta, Georgia); Chen Ma (Atlanta, Georgia); Meisha Shofner (Atlanta, Georgia); Scott Sinquefield (Atlanta, Georgia); Zhongzhen Wang (Atlanta, Georgia) |
| ABSTRACT | Disclosed herein are membranes comprising: porous substrate; and two or more graphene oxide (GO) sheets disposed on the porous substrate, each GO layer comprising a plurality of GO flakes, each GO flake comprising a planar graphene structure with oxygen moieties extending therefrom, wherein the membrane, when a pressure from 10 bar to 50 bar of transmembrane pressure is applied from 1 hour to 48 hours, has an aqueous flux wherein the aqueous flux changes by 5% or less while the pressure is applied. The membranes can also include an intercalating agent disposed between the two or more GO sheets, the intercalating agent interacting with each GO sheet, wherein the intercalating agent provides a non-covalent stabilization of the two or more GO sheets. Also disclosed herein are methods of making and using the same and systems for implementing the same. |
| FILED | Friday, May 22, 2020 |
| APPL NO | 17/612530 |
| CURRENT CPC | Separation B01D 67/00416 (20220801) Original (OR) Class B01D 69/10 (20130101) B01D 69/1213 (20220801) B01D 71/0211 (20220801) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/44 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220371057 | Kumar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sortera Alloys, Inc. (Fort Worth, Texas) |
| ASSIGNEE(S) | Sortera Alloys, Inc. (Fort Worth, Texas) |
| INVENTOR(S) | Nalin Kumar (Fort Worth, Texas); Manuel Gerardo Garcia, JR. (Fort Wayne, Indiana) |
| ABSTRACT | A system classifies materials utilizing a vision system that implements an artificial intelligence system in order to identify or classify and then remove automotive airbag modules from a scrap stream, which may have been produced from a shredding of end-of-life vehicles. The sorting process may be designed so that live airbag modules are not activated, which may cause damage to equipment or persons. |
| FILED | Friday, August 05, 2022 |
| APPL NO | 17/882506 |
| CURRENT CPC | Postal Sorting; Sorting Individual Articles, or Bulk Material Fit to be Sorted Piece-meal, e.g by Picking B07C 5/12 (20130101) B07C 5/3422 (20130101) Original (OR) Class B07C 2501/0036 (20130101) B07C 2501/0054 (20130101) Image Data Processing or Generation, in General G06T 7/0004 (20130101) G06T 7/10 (20170101) G06T 2207/20084 (20130101) Image or Video Recognition or Understanding G06V 10/82 (20220101) G06V 10/765 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220371067 | Whalen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Scott A. Whalen (West Richland, Washington); Darrell R. Herling (Kennewick, Washington); Xiao Li (Richland, Washington); MD. Reza-E-Rabby (Richland, Washington); Brandon Scott Taysom (West Richland, Washington); Glenn J. Grant (Benton City, Washington) |
| ABSTRACT | Shear-assisted extrusion processes for forming extrusions of a desired composition from a feedstock material are provided. The processes can include applying a rotational shearing force and an axial extrusion to the same location on the feedstock material. Devices for this can include a die tool defined by a die face extending from a rim of the die face inwardly at an angle greater than zero in relation to a sidewall of the die tool in at least one cross section; and/or a die tool defining an opening configured to receive feedstock material for extrusion and further defining a die face defining a recess within the die face and contiguous with the opening. Shear-assisted extrusion processes are also provided that can mix different portions of the feedstock material within a recess about the opening prior to feedstock material entering the opening; and extruding the mixed portions. |
| FILED | Tuesday, July 26, 2022 |
| APPL NO | 17/874140 |
| CURRENT CPC | Manufacture of Metal Sheets, Wire, Rods, Tubes or Profiles, Otherwise Than by Rolling; Auxiliary Operations Used in Connection With Metal-working Without Essentially Removing Material B21C 23/085 (20130101) B21C 25/02 (20130101) Original (OR) Class B21C 25/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220371094 | Bhattad et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Carl Zeiss Industrial Metrology, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| INVENTOR(S) | Pradeep Bhattad (Knoxville, Tennessee); Paul Brackman (Knoxville, Tennessee); Curtis Frederick (Knoxville, Tennessee); Marcin B. Bauza (Plymouth, Minnesota); Edson Costa Santos (Oberkochen, Germany); Ryan Dehoff (Knoxville, Tennessee); Alex Plotkowski (Knoxville, Tennessee); Aleksandr Lisovich (Plymouth, Minnesota); Jason James Tenboer (Elk River, Minnesota) |
| ABSTRACT | An apparatus includes a control system that defines a test part having multiple features of multiple feature types. The control system controls an additive manufacturing (AM) machine to print multiple copies of the test part, with each copy being printed according to a respective set of values used as printing parameters. A measurement system obtains a computed tomography (CT) image of each of the copies of the test part. An analysis system, for each of the plurality of feature types, analyzes the CT images to identify a selected set of values for the printing parameters. The analysis system identifies a portion of the CT image related to a first feature and assesses its density based on an average grayscale value. The AM machine is then controlled to print production parts according to, for each feature type of the production parts, the selected set of values for the printing parameters. |
| FILED | Wednesday, November 18, 2020 |
| APPL NO | 17/777598 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/28 (20210101) B22F 10/85 (20210101) Original (OR) Class B22F 12/90 (20210101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 50/02 (20141201) Image Data Processing or Generation, in General G06T 7/0006 (20130101) G06T 7/337 (20170101) G06T 11/005 (20130101) G06T 2207/30144 (20130101) Image or Video Recognition or Understanding G06V 10/44 (20220101) G06V 30/18019 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220371266 | Huang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jen-Yu Huang (Ithaca, New York); Tangi Aubert (Ithaca, New York); Tobias Hanrath (Ithaca, New York); Ulrich B. Wiesner (Ithaca, New York) |
| ABSTRACT | Provided are compositions that may be referred to as photoreactive compositions or inks. The compositions may have a plurality of reactive components, which are silica nanocages with one or more photoreactive ligand(s). Also provided are methods of making an article of manufacture. Also provided are articles of manufacture and uses thereof. The article of manufacture may be formed from a composition of the present disclosure. |
| FILED | Monday, November 02, 2020 |
| APPL NO | 17/772178 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/153 (20170801) Original (OR) Class Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2509/00 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) B33Y 80/00 (20141201) Non-metallic Elements; Compounds Thereof; C01B 33/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220371280 | Barocio et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Eduardo Barocio (West Lafayette, Indiana); Jorge A. Ramirez (West Lafayette, Indiana); Miguel Angel Ramirez (Lafayette, Indiana); Bastian Brenken (Nottensdorf, Germany); Robert Byron Pipes (Lafayette, Indiana) |
| ABSTRACT | A method of depositing a multiphase material. The method includes providing a Continuous Multifunctional Composite (CMC) phase containing at least one continuous element in a polymeric matrix, passing the CMC phase through a feeding system containing a cutting system, producing a predetermined length of the CMC phase, providing a flow a molten polymer such that the molten polymer and the CMC phase are merged into a continuous co-extrusion nozzle so as to produce a co-extruded multiphase material, and depositing the co-extruded multiphase material onto a surface. An apparatus for depositing a multiphase material. The apparatus contains a co-extrusion nozzle, a means to introduce a CMC phase and a molten polymer into the co-extrusion nozzle, such that the molten polymer and the CMC phase are co-extruded and deposited on a surface. An article containing a CMC phase containing continuous elements embedded in a polymer resin forming a multiphase structure. |
| FILED | Sunday, January 02, 2022 |
| APPL NO | 17/567141 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/118 (20170801) B29C 64/209 (20170801) B29C 64/336 (20170801) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 40/00 (20141201) B33Y 70/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220371281 | Barocio et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Eduardo Barocio (West Lafayette, Indiana); Jorge A. Ramirez (West Lafayette, Indiana); Miguel Angel Ramirez (Lafayette, Indiana); Bastian Brenken (Nottensdorf, Germany); Robert Byron Pipes (Lafayette, Indiana) |
| ABSTRACT | A method of depositing a multiphase material. The method includes providing a Continuous Multifunctional Composite (CMC) phase containing at least one continuous element in a polymeric matrix, passing the CMC phase through a feeding system containing a cutting system, producing a predetermined length of the CMC phase, providing a flow a molten polymer such that the molten polymer and the CMC phase are merged into a continuous co-extrusion nozzle so as to produce a co-extruded multiphase material, and depositing the co-extruded multiphase material onto a surface. An apparatus for depositing a multiphase material. The apparatus contains a co-extrusion nozzle, a means to introduce a CMC phase and a molten polymer into the co-extrusion nozzle, such that the molten polymer and the CMC phase are co-extruded and deposited on a surface. An article containing a CMC phase containing continuous elements embedded in a polymer resin forming a multiphase structure. |
| FILED | Sunday, January 02, 2022 |
| APPL NO | 17/567143 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/118 (20170801) B29C 64/209 (20170801) B29C 64/336 (20170801) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 40/00 (20141201) B33Y 70/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220371282 | Barocio et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Eduardo Barocio (West Lafayette, Indiana); Jorge A. Ramirez (West Lafayette, Indiana); Miguel Angel Ramirez (Lafayette, Indiana); Bastian Brenken (Nottensdorf, Germany); Robert Byron Pipes (Lafayette, Indiana) |
| ABSTRACT | A method of depositing a multiphase material. The method includes providing a Continuous Multifunctional Composite (CMC) phase containing at least one continuous element in a polymeric matrix, passing the CMC phase through a feeding system containing a cutting system, producing a predetermined length of the CMC phase, providing a flow a molten polymer such that the molten polymer and the CMC phase are merged into a continuous co-extrusion nozzle so as to produce a co-extruded multiphase material, and depositing the co-extruded multiphase material onto a surface. An apparatus for depositing a multiphase material. The apparatus contains a co-extrusion nozzle, a means to introduce a CMC phase and a molten polymer into the co-extrusion nozzle, such that the molten polymer and the CMC phase are co-extruded and deposited on a surface. An article containing a CMC phase containing continuous elements embedded in a polymer resin forming a multiphase structure. |
| FILED | Sunday, January 02, 2022 |
| APPL NO | 17/567146 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/118 (20170801) B29C 64/209 (20170801) B29C 64/336 (20170801) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 40/00 (20141201) B33Y 70/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220371896 | Zeller et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | H QUEST VANGUARD, INC. (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kurt W. Zeller (Pittsburgh, Pennsylvania); George L. Skoptsov (Pittsburgh, Pennsylvania); Evan T. Musselman (Pittsburgh, Pennsylvania) |
| ABSTRACT | Systems and methods for plasma based synthesis of graphitic materials. The system includes a plasma forming zone configured to generate a plasma from radio-frequency radiation, an interface element configured to transmit the plasma from the plasma forming zone to a reaction zone, and the reaction zone configured to receive the plasma. The reaction zone is further configured to receive feedstock material comprising a carbon containing species, and convert the feedstock material to a product comprising the graphitic materials in presence of the plasma. |
| FILED | Monday, June 13, 2022 |
| APPL NO | 17/806619 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/088 (20130101) B01J 19/126 (20130101) B01J 19/129 (20130101) B01J 2219/0875 (20130101) B01J 2219/0894 (20130101) B01J 2219/0896 (20130101) B01J 2219/0898 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/184 (20170801) Original (OR) Class Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 1/30 (20130101) H05H 1/4622 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220371918 | Shabgard et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of the University of Oklahoma (Norman, Oklahoma) |
| ASSIGNEE(S) | The Board of Regents of the University of Oklahoma (Norman, Oklahoma) |
| INVENTOR(S) | Hamidreza Shabgard (Norman, Oklahoma); Ramkumar Parthasarathy (Norman, Oklahoma); Jie Cai (Norman, Oklahoma); Reza Kaviani (Norman, Oklahoma); Aly Elhefny (Norman, Oklahoma) |
| ABSTRACT | A water treatment system is configured to remove salt from a feed brine. The water treatment system includes a primary freezing chamber configured to receive the feed brine and a source of cooled intermediate cold liquid connected to the primary freezing chamber. The cooled intermediate cold liquid and feed brine are mixed within the primary freezing chamber, where ice particles are formed. The water treatment system includes a rotary separator connected to a discharge from the primary freezing chamber. The rotary separator is configured to separate solid ice particles from liquid components in the discharge from the primary freezing chamber. In some embodiments, the rotary separator includes a mesh inner filter tube that is configured for rotation within a solid outer filter tube, where the mesh inner filter tube allows liquid components to drain into the outer filter tube while conveying solid ice particles to an ice recovery tank. |
| FILED | Friday, May 20, 2022 |
| APPL NO | 17/750113 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/001 (20130101) C02F 1/22 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220371970 | Bukovsky et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric V. Bukovsky (Livermore, California); Karl Thomas Lorenz (Livermore, California); Robert V. Reeves (Livermore, California); Harry K. Springer (Pleasanton, California) |
| ABSTRACT | An explosive with reduced detonation performance that includes an explosive powder that detonates with a reaction velocity of less than 5000 feet per second, a polymer resin, and an inert filler. |
| FILED | Friday, May 21, 2021 |
| APPL NO | 17/326863 |
| CURRENT CPC | Explosives or Thermic Compositions; Manufacture Thereof; Use of Single Substances as Explosives C06B 21/0058 (20130101) C06B 25/00 (20130101) C06B 25/32 (20130101) C06B 25/34 (20130101) C06B 45/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220371971 | VARDON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Derek Richard VARDON (Lakewood, Colorado); Xiangchen HUO (Golden, Colorado); Nabila HUQ (Golden, Colorado); Huong Thi Thanh NGUYEN (Arvada, Colorado) |
| ABSTRACT | The present disclosure relates to a method that includes a first treating of a first mixture that includes a carboxylic acid having between 2 and 12 carbon atoms, inclusively, to form a second mixture that includes a ketone having between 2 and 25 carbon atoms, inclusively, and a second treating of at least a first portion of the second mixture to form a first product that includes a paraffin having 8 or more carbon atoms. |
| FILED | Tuesday, July 12, 2022 |
| APPL NO | 17/862542 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 1/22 (20130101) Original (OR) Class C07C 9/15 (20130101) C07C 9/16 (20130101) C07C 45/41 (20130101) C07C 45/68 (20130101) Fuels Not Otherwise Provided for; Natural Gas; Synthetic Natural Gas Obtained by Processes Not Covered by Subclasses C10G, C10K; Liquefied Petroleum Gas; Adding Materials to Fuels or Fires to Reduce Smoke or Undesirable Deposits or to Facilitate Soot Removal; Firelighters C10L 1/04 (20130101) C10L 2200/0469 (20130101) C10L 2270/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372373 | Elliott et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Douglas C. Elliott (Richland, Washington); Gary G. Neuenschwander (Burbank, Washington); Todd R. Hart (Kennewick, Washington) |
| ABSTRACT | A combined hydrothermal liquefaction (HTL) and catalytic hydrothermal gasification (CHG) system and process are described that convert various biomass-containing sources into separable bio-oils and aqueous effluents that contain residual organics. Bio-oils may be converted to useful bio-based fuels and other chemical feedstocks. Residual organics in HTL aqueous effluents may be gasified and converted into medium-BTU product gases and directly used for process heating or to provide energy. |
| FILED | Wednesday, July 27, 2022 |
| APPL NO | 17/875269 |
| CURRENT CPC | Destructive Distillation of Carbonageous Materials for Production of Gas, Coke, Tar, or Similar Materials C10B 49/16 (20130101) Original (OR) Class Cracking Hydrocarbon Oils; Production of Liquid Hydrocarbon Mixtures, e.g by Destructive Hydrogenation, Oligomerisation, Polymerisation; Recovery of Hydrocarbon Oils From Oil-shale, Oil-sand, or Gases; Refining Mixtures Mainly Consisting of Hydrocarbons; Reforming of Naphtha; Mineral Waxes C10G 1/06 (20130101) C10G 1/065 (20130101) C10G 3/40 (20130101) C10G 3/50 (20130101) Production of Producer Gas, Water-gas, Synthesis Gas From Solid Carbonaceous Material, or Mixtures Containing These Gases; Carburetting Air or Other Gases C10J 3/00 (20130101) C10J 2200/06 (20130101) C10J 2300/0916 (20130101) C10J 2300/0973 (20130101) C10J 2300/1681 (20130101) Fuels Not Otherwise Provided for; Natural Gas; Synthetic Natural Gas Obtained by Processes Not Covered by Subclasses C10G, C10K; Liquefied Petroleum Gas; Adding Materials to Fuels or Fires to Reduce Smoke or Undesirable Deposits or to Facilitate Soot Removal; Firelighters C10L 3/08 (20130101) C10L 9/08 (20130101) C10L 9/086 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 50/10 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 20/145 (20151101) Y02P 30/20 (20151101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372429 | Pinowska et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Global Algae Technology, LLC (Santee, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Agnieszka Pinowska (San Diego, California); Rodney Corpuz (Lihue, Hawaii); David A. Hazlebeck (El Cajon, California) |
| ABSTRACT | A method of autotrophic cultivation of algae includes cultivating algae in the presence of cultivation media and at least one growth nutrient to produce an algal biomass; and harvesting the algal biomass by separating the algal biomass from the cultivation media and the at least one growth nutrient. The algal biomass comprises at least 35% fatty acid lipid content and at least 30% protein content on an ash-free dry weight basis |
| FILED | Tuesday, May 17, 2022 |
| APPL NO | 17/746448 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/02 (20130101) C12N 1/12 (20130101) Original (OR) Class C12N 1/38 (20130101) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/89 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372526 | Hamberger et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Björn Hamberger (Okemos, Michigan); Sean Johnson (Bedford, Massachusetts); Wajid Waheed Bhat (Srinagar, J&K, India) |
| ABSTRACT | Enzymes and methods are described herein for manufacturing terpenes, including terpenes. |
| FILED | Friday, August 02, 2019 |
| APPL NO | 17/265482 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1022 (20130101) C12N 9/1085 (20130101) C12N 15/8243 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 5/002 (20130101) Original (OR) Class C12P 17/02 (20130101) C12P 17/06 (20130101) Enzymes C12Y 202/01007 (20130101) C12Y 205/01029 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372630 | Jordan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of Connecticut (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric Jordan (Storrs, Connecticut); Maurice Gell (Somerset, New Jersey); Rishi Kumar (Ashford, Connecticut); Chen Jiang (Willimantic, Connecticut) |
| ABSTRACT | A coating on a substrate is disclosed having layers including yttrium aluminum garnet (YAG) and yttrium aluminum monoclinic (YAM). |
| FILED | Monday, August 01, 2022 |
| APPL NO | 17/878868 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 28/042 (20130101) C23C 28/044 (20130101) C23C 28/3455 (20130101) Original (OR) Class Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/288 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2230/90 (20130101) F05D 2260/95 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372638 | He et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ting He (Idaho Falls, Idaho); Dong Ding (Idaho Falls, Idaho); Chenlin Li (Idaho Falls, Idaho) |
| ABSTRACT | A method of carbon dioxide hydrogenation comprises introducing gaseous water to a positive electrode of an electrolysis cell comprising the positive electrode, a negative electrode, and a proton-conducting membrane between the positive electrode and the negative electrode. The proton-conducting membrane comprises an electrolyte material having an ionic conductivity greater than or equal to about 10−2 S/cm at one or more temperatures within a range of from about 150° C. to about 650° C. Carbon dioxide is introduced to the negative electrode of the electrolysis cell. A potential difference is applied between the positive electrode and the negative electrode of the electrolysis cell to generate hydrogen ions from the gaseous water that diffuses through the proton-conducting membrane and hydrogenates the carbon dioxide at the negative electrode. A carbon dioxide hydrogenation system is also described. |
| FILED | Wednesday, July 27, 2022 |
| APPL NO | 17/815504 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 3/045 (20130101) C01B 2203/067 (20130101) C01B 2203/0272 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 3/25 (20210101) Original (OR) Class C25B 9/23 (20210101) C25B 11/04 (20130101) C25B 13/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372642 | REN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Houston System (Houston, Texas) |
| ASSIGNEE(S) | University of Houston System (Houston, Texas) |
| INVENTOR(S) | Zhifeng REN (Pearland, Texas); Fang YU (Houston, Texas); Haiqing ZHOU (Houston, Texas); Shuo CHEN (Houston, Texas) |
| ABSTRACT | A method of manufacturing a bifunctional electrocatalyst for overall water splitting comprising oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) by growing electrocatalyst comprising primarily metallic phosphides on three-dimensional substrate by: immersing the substrate in an iron nitrate solution to form a once disposed substrate; subjecting the once disposed substrate to thermal phosphidation with phosphorus powder under inert gas to grow metal phosphides thereupon and form a once subjected substrate; cooling the once subjected substrate to form a cooled, once subjected substrate; immersing the cooled, once subjected substrate in an iron nitrate solution to form a twice disposed substrate; and subjecting the twice disposed substrate to thermal phosphidation with phosphorus powder under inert gas to provide an electrode comprising the bifunctional electrocatalyst on the three-dimensional substrate. An electrode for overall water splitting having a substrate and a bifunctional electrocatalyst comprising primarily metallic phosphides on a surface of the substrate. |
| FILED | Tuesday, May 31, 2022 |
| APPL NO | 17/828172 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/18 (20130101) C23C 16/30 (20130101) C23C 16/045 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/04 (20130101) C25B 11/061 (20210101) C25B 11/075 (20210101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220373137 | Elgowainy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UChicago Argonne, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amgad A. Elgowainy (Lisle, Illinois); Krishna R. Reddi (Bolingbrook, Illinois) |
| ABSTRACT | A method and a precooling system are provided for precooling gaseous fuel supplied for fueling pressurized gaseous vehicle onboard storage tank systems. The precooling system is used in pressurized gaseous fueling stations with source fuels in cryogenic state, such as liquid hydrogen (LH2) and liquefied nature gas (LNG). A thermal buffer heat exchanger includes a heat exchanger medium, and a cold loop and a warm loop contained in the heat exchanger medium. A control unit is configured for controlling cryogenic fuel supplied to the cold loop for cooling the thermal buffer heat exchanger. The thermal buffer heat exchanger enables precooling high pressure gaseous fuel to a preset temperature supplied to a dispenser supplying high pressure gaseous fuel to refuel a vehicle onboard storage tank system. |
| FILED | Thursday, May 20, 2021 |
| APPL NO | 17/325819 |
| CURRENT CPC | Vessels for Containing or Storing Compressed, Liquefied or Solidified Gases; Fixed-capacity Gas-holders; Filling Vessels With, or Discharging From Vessels, Compressed, Liquefied, or Solidified Gases F17C 7/04 (20130101) Original (OR) Class F17C 2221/012 (20130101) F17C 2221/033 (20130101) F17C 2223/0161 (20130101) F17C 2225/0123 (20130101) F17C 2227/0135 (20130101) F17C 2227/0323 (20130101) F17C 2227/0355 (20130101) F17C 2250/032 (20130101) F17C 2250/0636 (20130101) F17C 2265/065 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220373229 | MCKINION et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Helical Solar Solutions, LLC (Austin, Texas) |
| ASSIGNEE(S) | Helical Solar Solutions, LLC (Austin, Texas) |
| INVENTOR(S) | JAMES MCKINION (AUSTIN, Texas); KEITH BECKER (CEDAR PARK, Texas) |
| ABSTRACT | A load support system includes an elongate support member having a first diameter and a first end and a second end. The elongate support member includes, toward the first end, a first portion for direct earth burial and further includes, toward the second end, a second portion to which the load can be coupled. The first portion has a first length. The system additionally includes a lateral support having a second diameter greater than the first diameter and a second length less than the first length. The lateral support is mounted about the first portion of the elongate support member. The lateral support includes a first opening formed therein at a first location relative to a long axis of the elongate support member and a second opening formed therein at a different second location relative to the long axis in order to support a range of embedment depths. |
| FILED | Tuesday, April 26, 2022 |
| APPL NO | 17/729879 |
| CURRENT CPC | Solar Heat Collectors; Solar Heat Systems F24S 25/12 (20180501) Original (OR) Class F24S 25/617 (20180501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220373397 | Gopinath et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Juliet T. Gopinath (Boulder, Colorado); Greg Krueper (Boulder, Colorado); Lior Cohen (Denver, Colorado) |
| ABSTRACT | An entanglement-enhanced interferometry system includes a source of correlated photons configured to two-mode squeezed vacuum (TMSV), a polarizing splitter or off-axis polarizing coupler configured to separate the correlated photons into two paths, a polarization control device configured to rotate polarization of photons on one of the two paths relative to the photons on the other of the two paths in order to make photons indistinguishable, a coupler configured to entangle the indistinguishable photons, and a polarization maintaining fiber-based interferometer configured to use the entangled photons as the input state. The source of correlated photons might be a nonlinear element such as a periodically poled element such as a lithium niobate bulk crystal or waveguide. The interferometer might be a Mach-Zehnder or a common path configuration. The coupler might be a 50:50 coupler or a polarizing coupler 45 degrees off-axis. |
| FILED | Wednesday, May 11, 2022 |
| APPL NO | 17/742277 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 9/02 (20130101) Original (OR) Class G01J 2009/0226 (20130101) G01J 2009/0261 (20130101) G01J 2009/0288 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/365 (20130101) G02F 1/395 (20130101) G02F 1/3503 (20210101) G02F 1/3536 (20130101) G02F 1/3558 (20130101) G02F 2202/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220373521 | Van Berkel |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-BATTELLE, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gary J. Van Berkel (Oak Ridge, Tennessee) |
| ABSTRACT | A system for sampling a sample material includes a probe which can have an outer probe housing with an open end. A liquid supply conduit within the housing has an outlet positioned to deliver liquid to the open end of the housing. The liquid supply conduit can be connectable to a liquid supply for delivering liquid at a first volumetric flow rate to the open end of the housing. A liquid exhaust conduit within the housing is provided for removing liquid from the open end of the housing. A liquid exhaust system can be provided for removing liquid from the liquid exhaust conduit at a second volumetric flow rate. A droplet dispenser can dispense drops of a sample or a sample-containing solvent into the open end of the housing. A sensor and a processor can be provided to monitor and maintain a liquid dome present at the open end. |
| FILED | Tuesday, April 26, 2022 |
| APPL NO | 17/729701 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/443 (20130101) A61B 10/02 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/00 (20130101) G01N 1/20 (20130101) G01N 30/7233 (20130101) Original (OR) Class G01N 35/1095 (20130101) G01N 2030/027 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/0404 (20130101) H01J 49/0431 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220373555 | Pallares et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Roger Molto Pallares (Berkeley, California); Rebecca J. Abergel (Kensington, California) |
| ABSTRACT | The present invention provides for a method to detect and/or quantify a gadolinium-based contrast agents (GBCA) in a sample, the method comprising: (a) providing a sample, (b) contacting the sample with a luminescent agent so that luminescent agent chelates a Gd3+ cation of the GBCA, and (c) measuring quenching of a luminescence emission within a range of wavelength; wherein the quenching of the luminescence emission corresponds to the amount of luminescent agent chelating a Gd3+ cation. |
| FILED | Thursday, April 28, 2022 |
| APPL NO | 17/731313 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/76 (20130101) G01N 21/6428 (20130101) G01N 33/582 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220374036 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RAYTHEON TECHNOLOGIES CORPORATION (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kaiyu Wang (Round Rock, Texas); Vladimir Blasko (Avon, Connecticut); William A. Veronesi (Hartford, Connecticut); Moon C. Kim (Glastonbury, Connecticut); Robert K. Thornton (Coventry, Connecticut) |
| ABSTRACT | An energy storage assembly includes an energy storage unit. A supervisor is operable to determine a power reference set point based upon a cost function. A storage unit controller is configured to control the energy storage unit to provide electric energy to at least one load based upon a power reference input that is based upon the power reference set point and at least one dynamically changing power profile from the at least one load. |
| FILED | Monday, May 02, 2022 |
| APPL NO | 17/734390 |
| CURRENT CPC | Elevators; Escalators or Moving Walkways B66B 1/24 (20130101) B66B 1/302 (20130101) Systems for Regulating Electric or Magnetic Variables G05F 1/66 (20130101) Original (OR) Class Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/003 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220374515 | Bridges et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert A. Bridges (Oak Ridge, Tennessee); Kiren E. Verma (Oak Ridge, Tennessee); Michael Iannacone (Oak Ridge, Tennessee); Samuel C. Hollifield (Oak Ridge, Tennessee); Pablo Moriano (Oak Ridge, Tennessee); Jordan Sosnowski (Oak Ridge, Tennessee) |
| ABSTRACT | A system and method for intrusion detection on automotive controller area networks. The system and method can detect various CAN attacks, such as attacks that cause unintended acceleration, deactivation of vehicle's brakes, or steering the vehicle. The system and method detects changes in nuanced correlations of CAN timeseries signals and how they cluster together. The system reverse engineers CAN signals and detect masquerade attacks by analyzing timeseries extracted from raw CAN frames. Specifically, anomalies in the CAN data can be detected by computing timeseries clustering similarity using hierarchical clustering on the vehicle's CAN signals and comparing the clustering similarity across CAN captures with and without attacks. |
| FILED | Thursday, April 21, 2022 |
| APPL NO | 17/725774 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/552 (20130101) G06F 21/554 (20130101) G06F 21/556 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 12/40026 (20130101) H04L 2012/40215 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220375684 | Wolf |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph Ambrose Wolf (Olathe, Kansas) |
| ABSTRACT | Systems and methods of additively manufacturing passive electronic components are provided. An additive manufacturing device may deposit a material to create a passive electronic component. A sensor may continuously measure an electrical property of the passive electronic component across two electrical contacts as the material is deposited during manufacturing. The sensor may transmit the measured electrical property to a processor whereby the processor may adjust a material deposition rate of the additive manufacturing device. The continuous measurement of the electrical property and adjustment of the material deposition rate as the passive electronic component is produced allows for passive electronic components to be manufactured to a high degree of accuracy of the electrical property. |
| FILED | Friday, March 18, 2022 |
| APPL NO | 17/698326 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/85 (20210101) B22F 12/90 (20210101) Shaping Clay or Other Ceramic Compositions; Shaping Slag; Shaping Mixtures Containing Cementitious Material, e.g Plaster B28B 1/001 (20130101) B28B 17/0081 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/393 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 50/02 (20141201) B33Y 80/00 (20141201) Resistors H01C 17/065 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 41/043 (20130101) Original (OR) Class Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 4/33 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/162 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220375691 | Chowdhury et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shajjad Chowdhury (Oak Ridge, Tennessee); Raj Sahu (Mountain View, California); Emre Gurpinar (Knoxville, Tennessee); Burak Ozpineci (Oak Ridge, Tennessee) |
| ABSTRACT | A capacitor packaging having a central termination and three or more capacitors (or groups of capacitors) arranged about the central termination. The electrical flow paths between the termination and the capacitors or groups of capacitors are of substantially the same length. The capacitors or groups of capacitors may be arranged in a generally circular pattern with the termination centered on the center. The termination may include first and second terminals. The capacitors may be mounted to a printed circuit board (“PCB”) with traces on opposite surfaces of the PCB providing electrical flow paths from the terminals to opposite legs of the capacitors. The capacitor packaging may include a primary PCB with a first circular arrangement of capacitors and a secondary PCB with a second circular arrangement of capacitors. The capacitors may be sandwiched between the PCBs with the second arrangement of capacitors disposed concentrically inwardly of the first arrangement. |
| FILED | Thursday, May 12, 2022 |
| APPL NO | 17/742690 |
| CURRENT CPC | Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 4/38 (20130101) Original (OR) Class H01G 4/232 (20130101) H01G 4/1245 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/162 (20130101) H05K 2201/09227 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220376190 | Li et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jian Li (Tempe, Arizona); Yunlong Ji (Mesa, Arizona) |
| ABSTRACT | Metal-assisted delayed fluorescent emitters employing benzo-imidazo-phenanthridine and analogues for full color displays and lighting applications. |
| FILED | Thursday, May 27, 2021 |
| APPL NO | 17/332100 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 15/006 (20130101) C07F 15/0033 (20130101) C07F 15/0086 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) C09K 2211/1074 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0084 (20130101) Original (OR) Class H01L 51/0085 (20130101) H01L 51/0087 (20130101) H01L 51/5016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220376223 | YADAV et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gautam G. YADAV (New York, New York); Xia WEI (New York, New York); Michael NYCE (New York, New York); Sanjoy BANERJEE (New York, New York) |
| ABSTRACT | A system and method for forming a metallic ion intercalated layered structure can include a housing, an electrolyte disposed in the housing, a counter-electrode disposed in the housing, and a working electrode disposed in the housing. The working electrode comprises a metallic support; and an electrode paste. The electrode paste can include an active material and a binder. The system can be used to form a layered structure having metallic ions from the metallic support intercalated into the layered structure based on cycling the working electrode. |
| FILED | Friday, October 30, 2020 |
| APPL NO | 17/772578 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/50 (20130101) H01M 4/52 (20130101) H01M 4/0445 (20130101) H01M 4/0459 (20130101) Original (OR) Class H01M 4/661 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220376232 | KUMTA |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania) |
| INVENTOR(S) | Prashant N. KUMTA (Pittsburgh, Pennsylvania) |
| ABSTRACT | The inventive concepts include at least an electrode architecture including a composite structure that includes engineered carbon nanofibers, a lithium-impervious elastic polymer, a copper collector and a lithium-containing cathode; dendrite-free, lithium metal-plated anode that includes the electrode architecture; and a lithium metal-based lithium ion battery that includes the lithium metal-plated anode, liquid and solid electrolytes and a lithium-free cathode. |
| FILED | Wednesday, November 04, 2020 |
| APPL NO | 17/773725 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/366 (20130101) Original (OR) Class H01M 4/0471 (20130101) H01M 4/625 (20130101) H01M 4/661 (20130101) H01M 10/0525 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220376240 | Luo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Huimin Luo (Knoxville, Tennessee); Sheng Dai (Knoxville, Tennessee); Tao Wang (Knoxville, Tennessee); Ilias Belharouak (Knoxville, Tennessee); Jianlin Li (Knoxville, Tennessee); Yaocai Bai (Knoxville, Tennessee) |
| ABSTRACT | A method for relithiating cathode material from spent lithium-based batteries, the method comprising: (i) mixing delithiated cathode material and a lithium salt with an ionic liquid in which the lithium salt is at least partially soluble to form an initial mixture; (ii) heating the initial mixture to a temperature of 100° C. to 300° C. to result in relithiation of the delithiated cathode material; and (iii) separating the ionic liquid from the relithiated cathode material; wherein, in embodiments, the cathode material is a lithium metal oxide, wherein the metal is selected from the group consisting of Ni, Co, Fe, Mn, Al, Zr, Ti, Nb, and combinations thereof, or wherein the cathode material has the formula LiNixMnyCozO2, wherein x>0, y>0, z>0, and x+y+z=1; wherein, in some embodiments, the ionic liquid has a nitrogen-containing cationic portion, such as an imidazolium ionic liquid. |
| FILED | Wednesday, May 04, 2022 |
| APPL NO | 17/736426 |
| CURRENT CPC | Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 53/50 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/04 (20130101) H01M 4/505 (20130101) H01M 4/525 (20130101) Original (OR) Class H01M 2004/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220376246 | Anderson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John S. Anderson (Chicago, Illinois); Noah E. Horwitz (Chicago, Illinois); Jiaze Xie (Chicago, Illinois) |
| ABSTRACT | A lamellar transition metal sulfide composition having layers of an amorphous transition metal sulfide with cations interspersed between the layers is described. Also described are methods of synthesizing the lamellar transition metal sulfides and the use of the lamellar transition metal sulfides in electrodes, e.g., in metal-ion batteries, metal-ion/sulfur batteries, and capacitors. |
| FILED | Tuesday, September 29, 2020 |
| APPL NO | 17/765176 |
| CURRENT CPC | Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 9/042 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/58 (20130101) Original (OR) Class H01M 4/136 (20130101) H01M 4/366 (20130101) H01M 4/622 (20130101) H01M 4/623 (20130101) H01M 4/663 (20130101) H01M 10/0525 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220376312 | CHEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zheng CHEN (San Diego, California); Yang SHI (San Diego, California); Panpan XU (San Diego, California) |
| ABSTRACT | Regeneration of degraded cathode particles in lithium-ion batteries is achieved using a combination of hydrothermal treatment of cycled electrode particles followed by short thermal annealing. The methods provide for direct regeneration of Li-ion cathode materials including LiCoO2, LiMn2O4, LiFePO4, and LixNiy Mnz Co1−y−zO2, in an economical and environmentally-friendly process. |
| FILED | Thursday, March 17, 2022 |
| APPL NO | 17/697889 |
| CURRENT CPC | Compounds of Alkali Metals, i.e Lithium, Sodium, Potassium, Rubidium, Caesium, or Francium C01D 15/08 (20130101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 45/1228 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 4/5825 (20130101) H01M 10/0525 (20130101) H01M 10/4242 (20130101) Original (OR) Class H01M 2004/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220376453 | Edwards et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Reid Edwards (Livermore, California); Pierre Michel (Oakland, California) |
| ABSTRACT | A diffractive optical element, such as a plasma grating, can be made by directing two laser beams so that they overlap in a nonlinear material to form an interference pattern in the nonlinear material. The interference pattern can modify the index of refraction in the nonlinear material to produce the diffractive optical element. A chirped pulse amplification system can stretch, amplify, and then compress a laser pulse, and the plasma grating can be used to compress the laser pulse since the plasma optic can withstand the high light intensity of the compressed pulse. |
| FILED | Monday, May 09, 2022 |
| APPL NO | 17/740105 |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/0057 (20130101) Original (OR) Class H01S 3/2308 (20130101) H01S 3/08009 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220377845 | Baset et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho); University of Utah Research Foundation (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aniqua Z. Baset (Salt Lake City, Utah); Christopher D. Becker (Aitkin, Minnesota); Samuel Ramirez (Shelley, Idaho); Sneha K. Kasera (Salt Lake City, Utah); Kurt W. Derr (Idaho Falls, Idaho) |
| ABSTRACT | Processing flows and related systems and methods are disclosed. A computing system includes one or more data interfaces, one or more other components, and a controller. The one or more data interfaces are configured to provide an interface to a data source. The one or more other components include one or more controller plugins, one or more processing nodes, or both the one or more controller plugins and the one or more processing nodes. The controller is configured to manage interactions between the one or more data interfaces and the one or more other components and enable a user to chain together the one or more data interfaces and the one or more other components according to one or more flows. The one or more controller plugins are configured to provide results of the one or more flows to one of a user interface and a system interface. |
| FILED | Friday, October 30, 2020 |
| APPL NO | 17/755299 |
| CURRENT CPC | Wireless Communication Networks H04W 24/08 (20130101) H04W 24/10 (20130101) H04W 88/12 (20130101) Original (OR) Class H04W 88/085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220377882 | Diamond |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| INVENTOR(S) | Louis Diamond (Kansas City, Missouri) |
| ABSTRACT | A blank package for mimicking an electronic component package comprises a body and a plurality of conductive pads. The body is formed from generally transparent electrically insulating material and has a top surface, a bottom surface, and a plurality of side surfaces. The bottom surface has a shape and dimensions that are similar to a bottom surface of the electronic component package. The conductive pads are formed from electrically conductive material and attached to the body, with each conductive pad corresponding to a successive one of the conductive pads of the electronic component package. Each conductive pad has features that are similar to features of the corresponding conductive pad of the electronic component package. |
| FILED | Wednesday, July 06, 2022 |
| APPL NO | 17/858336 |
| CURRENT CPC | Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/09 (20130101) H05K 1/111 (20130101) H05K 1/0274 (20130101) Original (OR) Class H05K 1/0306 (20130101) H05K 2201/0108 (20130101) H05K 2201/0338 (20130101) H05K 2201/0344 (20130101) H05K 2201/09418 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220377888 | Diamond |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| INVENTOR(S) | Louis Diamond (Kansas City, Missouri) |
| ABSTRACT | A blank package for mimicking an electronic component package comprises a body and a plurality of conductive pads. The body is formed from generally transparent electrically insulating material and has a top surface, a bottom surface, and a plurality of side surfaces. The bottom surface has a shape and dimensions that are similar to a bottom surface of the electronic component package. The conductive pads are formed from electrically conductive material and attached to the body, with each conductive pad corresponding to a successive one of the conductive pads of the electronic component package. Each conductive pad has features that are similar to features of the corresponding conductive pad of the electronic component package. |
| FILED | Thursday, January 20, 2022 |
| APPL NO | 17/579974 |
| CURRENT CPC | Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/09 (20130101) H05K 1/11 (20130101) Original (OR) Class H05K 1/0274 (20130101) H05K 1/0306 (20130101) H05K 2201/0108 (20130101) H05K 2201/0338 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20220370641 | Delcamp et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF MISSISSIPPI (Oxford, Mississippi) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jared Heath Delcamp (Oxford, Mississippi); David Ndaleh Dodah Nghombui (Oxford, Mississippi); William Edward Meador (Oxford, Mississippi) |
| ABSTRACT | Described herein are new silicone-based compounds that have short wavelength infrared (SWIR) absorption and emission. The silicone-based compounds are readily accessible and obtainable on large scale with high purity through simple purification procedures. In one aspect, the silicone-based compounds have an absorption extending into the SWIR region and an emission maximum in the SWIR region which is promising for biological imaging applications. |
| FILED | Monday, May 09, 2022 |
| APPL NO | 17/662574 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/0021 (20130101) Original (OR) Class Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 57/00 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) C09K 2211/1007 (20130101) C09K 2211/1018 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370643 | Yap et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Michigan Technological University (Houghton, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yoke Khin Yap (Houghton, Michigan); Dongyan Zhang (Houghton, Michigan); Nazmiye Yapici (South Lyon, Michigan); Xiuling Liu (Ann Arbor, Michigan) |
| ABSTRACT | A compound includes a first linker having a first end connected to the carrier, a second linker having a first end connected to the carrier, a third linker having a first end connected to the carrier, a first fluorescent entity connected to a second end of the first linker, a second fluorescent entity different from the first fluorescent entity connected to a second end of the second linker, and a biomolecule connected to a second end of the third linker. The biomolecule is configured to connect to a biomarker. A method of detecting biomarkers is also disclosed. |
| FILED | Wednesday, September 30, 2020 |
| APPL NO | 17/765310 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/0054 (20130101) Original (OR) Class Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/533 (20130101) G01N 33/54353 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370679 | Vatankhan-Varnosfaderani et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mohammad Vatankhan-Varnosfaderani (San Diego, California); Sergei Sheiko (Chapel Hill, North Carolina); Erfan Dashtimoghadam (Chapel Hill, North Carolina) |
| ABSTRACT | Materials and methods related to elastomers are disclosed. The disclosed elastomers are useful in implants mimicking soft tissue. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| FILED | Friday, October 02, 2020 |
| APPL NO | 17/765546 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 24/06 (20130101) Original (OR) Class A61L 24/046 (20130101) A61L 27/16 (20130101) A61L 27/18 (20130101) A61L 2400/06 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/19 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370687 | Lee et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | Ki-Bum Lee (Monmouth Junction, New Jersey); Letao Yang (Piscataway, New Jersey) |
| ABSTRACT | A three dimensional scaffold for generating cell or protein assemblies. This degradable scaffold can be applied to various types of cells. Also disclosed are methods of treating a condition by implanting the protein or cell assembly prepared according to the method described herein. |
| FILED | Tuesday, May 24, 2022 |
| APPL NO | 17/664792 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/14 (20130101) A61L 27/025 (20130101) A61L 27/56 (20130101) Original (OR) Class A61L 2400/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220371056 | Horowitz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AMP Robotics Corporation (Louisville, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matanya B. Horowitz (Golden, Colorado); James A. Bailey (Boulder, Colorado); John C. McCoy, JR. (Thornton, Colorado) |
| ABSTRACT | Systems and methods for sorting recyclable items and other materials are provided. In one embodiment, a system for sorting objects comprises: at least one imaging sensor; a controller comprising a processor and memory storage, wherein the controller receives image data captured by the image sensor; and at least one pusher device coupled to the controller, wherein the at least one pusher device is configured to receive an actuation signal from the controller. The processor is configured to detect objects travelling on a conveyor device and recognize at least one target item traveling on a conveyor device by processing the image data and to determine an expected time when the at least one target item will be located within a diversion path of the pusher device. The controller selectively generates the actuation signal based on whether a sensed object detected in the image data comprise the at least one target item. |
| FILED | Monday, June 20, 2022 |
| APPL NO | 17/844591 |
| CURRENT CPC | Postal Sorting; Sorting Individual Articles, or Bulk Material Fit to be Sorted Piece-meal, e.g by Picking B07C 1/04 (20130101) B07C 5/36 (20130101) B07C 5/367 (20130101) B07C 5/368 (20130101) B07C 5/3422 (20130101) Original (OR) Class B07C 2501/0054 (20130101) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 13/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220371181 | Ben-Tzvi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (Blacksburg, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pinhas Ben-Tzvi (Blacksburg, Virginia); Vinaykarthik Kamidi (Blacksburg, Virginia) |
| ABSTRACT | The present invention concerns a novel leg mechanism for quadrupedal locomotion. This design engages a linkage to couple assembly that only requires a single degree of actuation. The topological arrangement of the system produces a foot trajectory that is well-suited for dynamic gaits including trot-running, bounding, and galloping. |
| FILED | Wednesday, July 20, 2022 |
| APPL NO | 17/813772 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/1065 (20130101) Original (OR) Class B25J 9/1664 (20130101) B25J 17/00 (20130101) B25J 19/0091 (20130101) Motor Vehicles; Trailers B62D 57/032 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220371188 | Bhatia et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ankit Bhatia (Pittsburgh, Pennsylvania); Aaron Johnson (Pittsburgh, Pennsylvania); Matthew T. Mason (Pittsburgh, Pennsylvania) |
| ABSTRACT | A gripper includes at least one movable finger. Each movable finger includes a first motor, a second motor, a first motor link having a first end coupled to a rotor of the first motor, a second motor link having a first end coupled to a rotor of the second motor, a finger link having a first end in pivotal connection with a second end of the second motor link and a gripper pad, and a connecting link having a first end in pivotal connection with a second end of the first motor link and a second end in pivotal connection with the finger link. The gripper further includes at least one controller programmed or configured to actuate the first motor and the second motor of each of the at least one movable finger. |
| FILED | Friday, May 21, 2021 |
| APPL NO | 17/326719 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/12 (20130101) B25J 9/1612 (20130101) Original (OR) Class B25J 9/1633 (20130101) B25J 13/088 (20130101) B25J 15/0009 (20130101) B25J 15/0028 (20130101) Control or Regulation of Electric Motors, Electric Generators or Dynamo-electric Converters; Controlling Transformers, Reactors or Choke Coils H02P 29/64 (20160201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220371193 | CHU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Diligent Robotics, Inc. (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vivian Yaw-Wen CHU (Austin, Texas); Shuai LI (Sammamish, Washington); Forrest GREEN (Austin, Texas); Peter WORSNOP (Bethesda, Maryland); Andrea Lockerd THOMAZ (Austin, Texas) |
| ABSTRACT | Systems, apparatus, and methods are described for robotic learning and execution of skills. A robotic apparatus can include a memory, a processor, sensors, and one or more movable components (e.g., a manipulating element and/or a transport element). The processor can be operatively coupled to the memory, the movable elements, and the sensors, and configured to obtain information of an environment, including one or more objects located within the environment. In some embodiments, the processor can be configured to learn skills through demonstration, exploration, user inputs, etc. In some embodiments, the processor can be configured to execute skills and/or arbitrate between different behaviors and/or actions. In some embodiments, the processor can be configured to learn an environmental constraint. In some embodiments, the processor can be configured to learn using a general model of a skill. |
| FILED | Wednesday, March 09, 2022 |
| APPL NO | 17/690197 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 5/00 (20130101) B25J 9/06 (20130101) B25J 9/0081 (20130101) B25J 9/163 (20130101) B25J 9/1661 (20130101) Original (OR) Class B25J 9/1694 (20130101) B25J 11/0005 (20130101) B25J 15/00 (20130101) B25J 19/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220371219 | YADAMA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington State University (Pullman, Washington); UNIVERSITY OF MINNESOTA DULUTH (Duluth, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vikram YADAMA (Pullman, Washington); Ruben A. JERVES (Pullman, Washington); Matthew ARO (Duluth, Minnesota) |
| ABSTRACT | Improved wood strand panels suitable for construction are produced by first thermally modifying a plurality of wood strands that are thin in terms of thickness. Then, wood veneers are constructed from the thermally modified wood strands, at least some of which partially overlap one another. The wood veneers are on the order of 0.125 to 0.25 inches thick. Finally, the wood veneers, constructed from the thermally modified wood strands, are stacked on top of one another and connected using adhesive, pressure and temperature similar to plywood or LVL manufacture. The thermal modification and use of thin strands, followed by veneer formation, prior to manufacture of the composite results in a composite with uniform density, high-strength, resistance to decay, resistance to water sorption, and other benefits. |
| FILED | Monday, May 16, 2022 |
| APPL NO | 17/745174 |
| CURRENT CPC | Working Veneer or Plywood B27D 1/04 (20130101) Original (OR) Class Manufacture by Dry Processes of Articles, With or Without Organic Binding Agents, Made From Particles or Fibres Consisting of Wood or Other Lignocellulosic or Like Organic Material B27N 1/00 (20130101) B27N 3/04 (20130101) Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 21/13 (20130101) B32B 21/14 (20130101) B32B 37/12 (20130101) B32B 2260/026 (20130101) B32B 2309/12 (20130101) B32B 2309/025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220371266 | Huang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jen-Yu Huang (Ithaca, New York); Tangi Aubert (Ithaca, New York); Tobias Hanrath (Ithaca, New York); Ulrich B. Wiesner (Ithaca, New York) |
| ABSTRACT | Provided are compositions that may be referred to as photoreactive compositions or inks. The compositions may have a plurality of reactive components, which are silica nanocages with one or more photoreactive ligand(s). Also provided are methods of making an article of manufacture. Also provided are articles of manufacture and uses thereof. The article of manufacture may be formed from a composition of the present disclosure. |
| FILED | Monday, November 02, 2020 |
| APPL NO | 17/772178 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/153 (20170801) Original (OR) Class Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2509/00 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) B33Y 80/00 (20141201) Non-metallic Elements; Compounds Thereof; C01B 33/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220371272 | Pearlson |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Igneous IP Holdings, LLC (Wales, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew N. Pearlson (Wales, Wisconsin) |
| ABSTRACT | An additive manufacturing technique uses digital mask-based illumination and a polar-based build environment for increased throughput. In one embodiment, the build environment comprises a rotating element having a surface. A coater is configured to deposit photopolymer material on the rotating element at a given flow rate. As the element rotates and the coater deposits the photopolymer material, a radiation source of an image scanning system projects an array of point sources (an image) onto the photopolymer material for an exposure time to cure a given layer. As the photopolymer material is deposited layer-upon-layer, and for each layer, a control system adjusts a relative position of the coater with respect to the surface, adjusts a speed of rotation of the rotating element, and maintains the flow rate and the exposure time constant. |
| FILED | Friday, May 20, 2022 |
| APPL NO | 17/749315 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/124 (20170801) B29C 64/245 (20170801) Original (OR) Class B29C 64/277 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 40/20 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220371284 | Feng et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NEW YORK UNIVERSITY (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chen Feng (New York, New York); Xuchu Xu (Brooklyn, New York) |
| ABSTRACT | A display guided robotic navigation and control system comprises a display system including a display surface and a display device configured to display an image including a visual pattern onto the display surface, a robotic system including a mobile robotic device and an optical sensor attached to the mobile robotic device, and a computing system communicatively connected to the display system and the robotic system. Related methods are also disclosed. |
| FILED | Friday, May 06, 2022 |
| APPL NO | 17/738164 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/163 (20130101) B25J 9/1607 (20130101) B25J 9/1664 (20130101) B25J 9/1692 (20130101) B25J 9/1697 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/209 (20170801) B29C 64/227 (20170801) B29C 64/393 (20170801) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 30/00 (20141201) B33Y 50/02 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220371547 | SHIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan); THE UNIVERSITY OF COLORADO (Denver, Colorado) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan); THE UNIVERSITY OF COLORADO (Denver, Colorado) |
| INVENTOR(S) | Kang G. SHIN (Ann Arbor, Michigan); Liang HE (Denver, Colorado) |
| ABSTRACT | A driving authentication system is presented for a vehicle. The system includes: a dongle interfaced with a battery of the vehicle and an authenticator configured to receive a discharge current from the battery. The dongle operates to modulate discharge current from the battery with an input code; and the authenticator demodulate the input code from the discharge current, compares the input code to the one or more known authentication codes and, in response to the input code matching one of the one or more known authentication codes, controls power capacity of the battery. |
| FILED | Thursday, March 24, 2022 |
| APPL NO | 17/703346 |
| CURRENT CPC | Vehicles, Vehicle Fittings, or Vehicle Parts, Not Otherwise Provided for B60R 25/04 (20130101) B60R 25/23 (20130101) Original (OR) Class B60R 25/1001 (20130101) Starting of Combustion Engines; Starting Aids for Such Engines, Not Otherwise Provided for F02N 11/087 (20130101) F02N 11/0862 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372009 | WEBSTER et al. |
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| FUNDED BY |
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| APPLICANT(S) | NDSU RSEARCH FOUNDATION (Fargo, North Dakota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dean C. WEBSTER (Fargo, North Dakota); Mukund P. SIBI (Fargo, North Dakota); Catherine A. SUTTON (Fargo, North Dakota); Deep J. KALITA (Fargo, North Dakota); Eric M. SERUM (Eau Claire, Wisconsin) |
| ABSTRACT | The invention relates to diols derived from 5-hydroxymethyl furfural, diformyl furan, or derivatives thereof. The invention further relates to diglycidyl ethers derived from the diols of the invention, curable coating compositions containing the diglycidyl ethers, and objects coated with the curable coating compositions. The invention also relates to composites, composites, adhesives, and films containing the diglycidyl ethers of the invention. The invention also relates to methods of making the diols, diglycidyl ethers, and curable coating compositions. |
| FILED | Monday, July 06, 2020 |
| APPL NO | 17/623405 |
| CURRENT CPC | Heterocyclic Compounds C07D 307/42 (20130101) Original (OR) Class C07D 407/14 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 163/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372116 | Lai et al. |
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| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Samuel Lai (Carrboro, North Carolina); M. Gregory Forest (Chapel Hill, North Carolina); Christine Henry (Chapel Hill, North Carolina); Timothy Wessler (Durham, North Carolina); Alexander Chen (Glenville, New York); Jennifer Schiller (Chapel Hill, North Carolina); Jay Newby (Carrboro, North Carolina) |
| ABSTRACT | The presently-disclosed subject matter relates to crosslinkers, compositions, and methods for trapping a target of interest on a substrate of interest. The methods may be used to inhibit and treat pathogen infection and provide contraception. The methods may be used to trap or separate particles and other substances. The subject matter further relates to methods of identifying and preparing optimal crosslinkers and methods for manipulating targets of interest. |
| FILED | Friday, March 18, 2022 |
| APPL NO | 17/698645 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/00 (20180101) Peptides C07K 16/44 (20130101) C07K 16/087 (20130101) C07K 16/1045 (20130101) C07K 16/1235 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/557 (20130101) G01N 33/6854 (20130101) G01N 33/54346 (20130101) G01N 33/56983 (20130101) G01N 2333/16 (20130101) G01N 2333/4725 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372200 | GIANNESCHI et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | Northwestern University (Evanston, Illinois) |
| INVENTOR(S) | Nathan C. GIANNESCHI (Evanston, Illinois); Hao SUN (Evanston, Illinois) |
| ABSTRACT | Aspects of the invention include a method for synthesizing a peptide brush polymer, the method comprising: exposing a mixture comprising peptide-containing monomers, one or more photoinitiators, and one or more chain transfer agents to a light sufficient to induce photopolymerization, and photopolymerizing the peptide-containing monomers in the mixture; wherein: the resulting peptide brush polymer comprises at least one peptide-containing polymer block; the at least one peptide-containing polymer block is characterized by a degree of polymerization of at least 10 and a peptide graft density of 50% to 100%; and at least one peptide moiety of the at least one peptide-containing polymer block has 5 or more amino acid groups. |
| FILED | Tuesday, September 29, 2020 |
| APPL NO | 17/764746 |
| CURRENT CPC | Peptides C07K 1/1077 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 2/10 (20130101) C08F 2/50 (20130101) C08F 299/022 (20130101) Original (OR) Class C08F 2438/03 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372234 | GAO et al. |
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| FUNDED BY |
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| APPLICANT(S) | ARYTHA BIOSCIENCES, LLC (San Diego, California) |
| ASSIGNEE(S) | ARYTHA BIOSCIENCES, LLC (San Diego, California) |
| INVENTOR(S) | Weiwei GAO (La Jolla, California); Che-Ming Jack HU (Taipei City, Taiwan) |
| ABSTRACT | The present invention relates to processes and systems for preparing nanoparticles, cellular or viral membranes and/or cellular or viral membrane coated nanoparticles using or comprising, inter alia, a multi-inlet vortexing reactor, tangential flow filtration (TFF) and/or a high shear fluid processor such as a microfluidizer (or a microfluidizer processor). The present invention also relates to the nanoparticles, cellular or viral membranes and/or cellular or viral membrane coated nanoparticles prepared by the present processes and systems, and the uses and/or applications of the nanoparticles, cellular or viral membranes and/or cellular or viral membrane coated nanoparticles. |
| FILED | Monday, May 23, 2022 |
| APPL NO | 17/751052 |
| CURRENT CPC | Separation B01D 61/146 (20220801) B01D 63/02 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/12 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0006 (20130101) C12N 5/0087 (20130101) C12N 5/0641 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372272 | ZHAO et al. |
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| FUNDED BY |
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| APPLICANT(S) | OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio); GEORGIA TECH RESEARCH CORPORATION (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ruike ZHAO (Columbus, Ohio); Xiao KUANG (Atlanta, Georgia); Hang QI (Atlanta, Georgia); Qiji ZE (Columbus, Ohio); Shuai WU (Columbus, Ohio) |
| ABSTRACT | Disclosed magnetic shape-memory compositions that comprise a polymer matrix and a population of hard-magnetic particles dispersed within the polymer matrix. In some embodiments, the magnetic shape-memory compositions can further comprise a population of auxiliary magnetic particles (e.g., ferrite particles) dispersed within the polymer matrix. The compositions can exhibit 1) reversible, fast, and controllable transforming deformation, 2) shape-locking, and 3) reprogramming capabilities. |
| FILED | Friday, June 19, 2020 |
| APPL NO | 17/621150 |
| CURRENT CPC | Compositions of Macromolecular Compounds C08L 63/00 (20130101) Original (OR) Class C08L 2201/12 (20130101) C08L 2203/02 (20130101) C08L 2207/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372441 | Papoutsakis et al. |
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| FUNDED BY |
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| APPLICANT(S) | Eleftherios Papoutsakis (Newark, Delaware); Chen-Yuan Kao (Newark, Delaware); Jinlin Jiang (Rockville, Maryland) |
| ASSIGNEE(S) | University of Delaware (Newark, Delaware) |
| INVENTOR(S) | Eleftherios Papoutsakis (Newark, Delaware); Chen-Yuan Kao (Newark, Delaware); Jinlin Jiang (Rockville, Maryland) |
| ABSTRACT | The present invention relates to a method for inducing megakaryocytic differentiation of hematopoietic stem/progenitor cells (HSPCs). The method comprises transferring into the HSPCs an effective amount of small RNAs. The HSPCs may differentiate into megakaryocytes in the absence of thrombopoietin (TPO) and/or without using megakaryocytic microparticles (MkMPs). The small RNAs may be micro RNAs (miRs) selected from the group consisting of miR-486, miR-22, miR-191, miR-181, miR-378, miR-26, let-7, miR-92, miR-126, miR-92, miR-21, miR-146, miR-181, and combinations thereof. For example, the small RNAs are miR-486 and miR-22. The small RNAs may be synthetic or isolated from cells. Also provided is a method for enhancing megakaryocytic differentiation of HSPCs cultured with megakaryocytic microparticles MkMPs in the presence of an effective amount of one or more exogenous small RNAs (e.g., miR-486). |
| FILED | Wednesday, October 21, 2020 |
| APPL NO | 17/770433 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0644 (20130101) Original (OR) Class C12N 15/113 (20130101) C12N 2310/141 (20130101) C12N 2501/65 (20130101) C12N 2506/11 (20130101) C12N 2527/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372451 | Eiteman et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Georgia Research Foundation, Inc. (Athens, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark Andrew Eiteman (Athens, Georgia); William Chris Moxley (Athens, Georgia) |
| ABSTRACT | Modified bacterial strains are provided. The strains can generate a desired product such as pyruvate and products derived from pyruvate. Methods of generating pyruvate and products derived from pyruvate are also provided. The modified bacterial strains have at least one mutation in a gene coding for proteins in a pyruvate dehydrogenase complex such that the mutation allows a cell to accumulate pyruvate and/or products derived from pyruvate. |
| FILED | Tuesday, April 26, 2022 |
| APPL NO | 17/729120 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0008 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372467 | Chatterjee et al. |
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| FUNDED BY |
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| APPLICANT(S) | TRUSTEES OF BOSTON COLLEGE (Chestnut Hill, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Abhishek Chatterjee (Lexington, Massachusetts); Rachel E. Kelemen (Newton, Massachusetts); Delilah Jewel (Chestnut Hill, Massachusetts) |
| ABSTRACT | The present invention involves the ability to 1) use a virus assisted directed evolution platform to significantly improve the activity of engineered nonsense-suppressor tRNAs in mammalian cells, 2) provide mutants of archaeal pyrrolysyl and E. coli leucyl tRNAs that show remarkably improved Uaa incorporation efficiency in mammalian cells, and 3) use these tRNAs to express recombinant proteins in mammalian cells incorporating Uaas at significantly improved yields. |
| FILED | Friday, June 19, 2020 |
| APPL NO | 17/620887 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/67 (20130101) C12N 15/86 (20130101) C12N 15/1058 (20130101) Original (OR) Class C12N 2750/14122 (20130101) C12N 2750/14143 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/02 (20130101) Enzymes C12Y 601/01026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372526 | Hamberger et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Björn Hamberger (Okemos, Michigan); Sean Johnson (Bedford, Massachusetts); Wajid Waheed Bhat (Srinagar, J&K, India) |
| ABSTRACT | Enzymes and methods are described herein for manufacturing terpenes, including terpenes. |
| FILED | Friday, August 02, 2019 |
| APPL NO | 17/265482 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1022 (20130101) C12N 9/1085 (20130101) C12N 15/8243 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 5/002 (20130101) Original (OR) Class C12P 17/02 (20130101) C12P 17/06 (20130101) Enzymes C12Y 202/01007 (20130101) C12Y 205/01029 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372553 | Madrid et al. |
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| FUNDED BY |
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| APPLICANT(S) | Andy Madrid (Madison, Wisconsin); Reid Spencer Alisch (Prairie du Sac, Wisconsin); Kirk Jeffrey Hogan (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andy Madrid (Madison, Wisconsin); Reid Spencer Alisch (Prairie du Sac, Wisconsin); Kirk Jeffrey Hogan (Madison, Wisconsin) |
| ABSTRACT | Provided herein is technology for Alzheimer's disease testing and particularly, but not exclusively, methods, compositions, and related uses for detecting the presence of Alzheimer's disease. |
| FILED | Friday, July 15, 2022 |
| APPL NO | 17/866284 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) Original (OR) Class C12Q 2600/154 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372585 | Moon et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Tae Seok Moon (St. Louis, Missouri); Hyojeong Yi (St. Louis, Missouri); Matthew Amrofell (St. Louis, Missouri); Chenggang Xi (St. Louis, Missouri); Austin Rottinghaus (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Tae Seok Moon (St. Louis, Missouri); Hyojeong Yi (St. Louis, Missouri); Matthew Amrofell (St. Louis, Missouri); Chenggang Xi (St. Louis, Missouri); Austin Rottinghaus (St. Louis, Missouri) |
| ABSTRACT | Among the various aspects of the present disclosure is the provision of molecular sensors, microbial sensors, constructs, systems, and methods for selectively detecting aromatic compounds. |
| FILED | Wednesday, April 27, 2022 |
| APPL NO | 17/731195 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/02 (20130101) C12Q 1/6897 (20130101) Original (OR) Class Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/19 (20210501) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/9406 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220373061 | Varenberg et al. |
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| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Varenberg (Atlanta, Georgia); Michael Leamy (Atlanta, Georgia); Yingdan Wu (Atlanta, Georgia) |
| ABSTRACT | A pulley belt (100) for transmitting force from a first pulley (12) to a second pulley (14) includes a belt member (110) having a contact surface (120) configured to be in contact with the first pulley (12) and the second pulley (14). A plurality of projections (122) extends from the contact surface (120). The projections have a predetermined height/diameter aspect ratio. In a method of making a pulley belt, an uncured elastomer (316) is placed in a mold (310) having a shape of a belt member (320) with an inner surface from which patterned projections (312) extend inwardly. The uncured elastomer is cured to form a cured belt member (320), which is removed from the mold (310). |
| FILED | Saturday, October 17, 2020 |
| APPL NO | 17/764171 |
| CURRENT CPC | Producing Particular Articles From Plastics or From Substances in a Plastic State B29D 29/00 (20130101) Belts, Cables, or Ropes, Predominantly Used for Driving Purposes; Chains; Fittings Predominantly Used Therefor F16G 1/10 (20130101) F16G 1/12 (20130101) F16G 1/28 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220373458 | YOUSSEF et al. |
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| FUNDED BY |
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| APPLICANT(S) | San Diego State University (SDSU) Fourndation, dba San Diego State University Research Foundation (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George YOUSSEF (Solana Beach, California); Nha Uyen HUYNH (La Jolla, California) |
| ABSTRACT | A testing apparatus for dynamic characterization of a sample of a material under test. A terahertz (THz) time-domain spectroscopy system is configured and arranged to generate and detect terahertz waves to interrogate the sample. A shock wave loading system is configured and arranged to produce a shock wave in the sample concurrently with said THz spectroscopy device interrogating the sample. The sample undergoes changes in an index of refraction in response to the produced ultrafast shock wave in the sample that are detected by the terahertz spectroscopy system. |
| FILED | Friday, October 30, 2020 |
| APPL NO | 17/770277 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/41 (20130101) G01N 21/3586 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220373463 | KELLEY et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTH CAROLINA (COLUMBIA, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | MATHEW L. KELLEY (COLUMBIA, South Carolina); ANDREW B. GREYTAK (COLUMBIA, South Carolina); MVS CHANDRASHEKHAR (COLUMBIA, South Carolina) |
| ABSTRACT | Spatially resolved Fourier Transform Impedance Spectroscopy (FTIS) is disclosed to spatially map and quickly build the frequency response of optoelectronic devices using optical probes. The transfer function of a linear system is the Fourier transform of its impulse response, which may be obtained from transient photocurrent measurements of devices such as photodetectors and solar cells. We apply FTIS to a PbS colloidal quantum dot (QD)/SiC heterojunction photodiode and corroborate results using intensity-modulated photocurrent spectroscopy. The cutoff frequencies of the QD/SiC devices were as high as ˜10 kHz, demonstrating their utility in advanced flexible and thin film electronics. The practical frequencies for FTIS lie in the mHz-kHz range, ideal for composite or novel materials such as QD films that are dominated by interfacial trap states. |
| FILED | Monday, March 07, 2022 |
| APPL NO | 17/688230 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6452 (20130101) Original (OR) Class G01N 21/6456 (20130101) G01N 2021/6423 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220373533 | Wanunu et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts); University of York (Heslington, United Kingdom) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Meni Wanunu (Needham, Massachusetts); Alfred Antson (Fulford, United Kingdom); Sandra Greive (York, United Kingdom); Benjamin Cressiot (Montlignon, France) |
| ABSTRACT | Hybrid nanopores, comprising a protein pore supported within a solid-state membrane, which combine the robust nature of solid-state membranes with the easily tunable and precise engineering of protein nanopores. In an embodiment, a lipid-free hybrid nanopore comprises a water soluble and stable, modified portal protein of the Thermus thermophilus bacteriophage G20c, electrokinetically inserted into a larger nanopore in a solid-state membrane. The hybrid pore is stable and easy to fabricate, and exhibits low peripheral leakage, allowing sensing and discrimination among different types of biomolecules. |
| FILED | Wednesday, June 29, 2022 |
| APPL NO | 17/809705 |
| CURRENT CPC | Microstructural Devices or Systems, e.g Micromechanical Devices B81B 1/002 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 15/00 (20130101) Peptides C07K 14/005 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/48721 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220373543 | Gopinath et al. |
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| FUNDED BY |
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| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ashwin Gopinath (Pasadena, California); Paul W.K. Rothemund (Pasadena, California) |
| ABSTRACT | Bistable devices are constructed using a polynucleotide platform for sensing molecular events such as binding or conformational changes of target molecules. Uses include measurement of target concentration, measuring the effect of environmental condition (such as heat, light, or pH) on the target, or screening a library for molecules that bind the target or modulate its biological function. Devices comprise three regions: a top lid, bottom lid, and flexible linker or hinge between them. A device has an open configuration in which the top and bottom lid are separated, and a closed configuration they are bound close together. Binding domains or variations of the target molecule are fixed to a device so that when the molecular event occurs, the device switches from open to closed, or vice versa, which generates a signal. Optimal device design is determined by the signal modality (optical or electronic) used to measure closure of surface-immobilized devices. |
| FILED | Thursday, June 02, 2022 |
| APPL NO | 17/830901 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) C12N 2310/20 (20170501) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/47 (20130101) G01N 21/553 (20130101) G01N 21/6428 (20130101) G01N 33/544 (20130101) G01N 33/54373 (20130101) Original (OR) Class G01N 2021/6439 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220373679 | Shahrestani |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MINNOWTECH (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Suzan Shahrestani (Baltimore, Maryland) |
| ABSTRACT | The invention relates to the use of sonar acoustic pulses to provide information about the status and composition of aquaculture farming tanks or ponds. In particular, the invention is directed to processes and systems comprising: a acoustic pulse transducer configured to transmit a acoustic pulse into an aquaculture farming tank or pond, a network of underwater sonar signal receivers; a computer connected to the network of underwater sonar signal receivers, said computer having a processor and memory, said memory having computer programming instructions saved thereon and executable on the processor, said computer programming instructions configured for receiving and comparing a signal difference between the acoustic pulse and the scattered return signal and for using the signal difference to output a signal difference data point related to a calculated shrimp biomass and distribution in the aquaculture farming tank or pond; a computer display connected to the computer and configured to display the signal difference data point related the calculated shrimp biomass and distribution. |
| FILED | Thursday, May 20, 2021 |
| APPL NO | 17/325219 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 79/00 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 15/10 (20130101) G01S 15/66 (20130101) G01S 15/96 (20130101) Original (OR) Class Electric Digital Data Processing G06F 21/44 (20130101) G06F 21/602 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 40/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220374390 | CHONG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE UNIVERSITY OF CHICAGO (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Frederic T. CHONG (Chicago, Illinois); Pranav GOKHALE (Chicago, Illinois); Yongshan DING (Chicago, Illinois); Thomas PROPSON (Chicago, Illinois) |
| ABSTRACT | A computing system includes a quantum processor with qubits, a classical memory including a quantum program defining a plurality of instructions in a source language, and a classical processor configured to: (i) receive a circuit of gates representing a quantum program for a variational algorithm in which computation is interleaved with compilation; (ii) identify a plurality of blocks, each block includes a subcircuit of gates, leaving one or more remainder subcircuits of the circuit of gates outside of the plurality of blocks; (iii) pre-compile each block of the plurality of blocks with a pulse generation program to generate a plurality of pre-compiled blocks including control pulses configured to perform the associated block on the quantum processor; and (iv) iteratively execute the quantum program using the pre-compiled blocks as static during runtime and recompiling the one or more remainder subcircuits on the classical processor at each iteration of execution. |
| FILED | Wednesday, September 09, 2020 |
| APPL NO | 17/641036 |
| CURRENT CPC | Electric Digital Data Processing G06F 15/82 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 10/40 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220374606 | Mosallanezhad et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ahmadreza Mosallanezhad (Tempe, Arizona); Ghazaleh Beigi (Tempe, Arizona); Huan Liu (Tempe, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on Behalf of Arizona State University (Tempe, Arizona) |
| INVENTOR(S) | Ahmadreza Mosallanezhad (Tempe, Arizona); Ghazaleh Beigi (Tempe, Arizona); Huan Liu (Tempe, Arizona) |
| ABSTRACT | Various embodiments of a system and associated method for anonymization of text without losing semantic utility of text by extracting a latent embedding representation of content with respect to a given task and by learning an optimal strategy for text embedding manipulation to satisfy both privacy and utility requirements are disclosed herein. In particular, the system balances private attribute obfuscation with retained semantic utility. |
| FILED | Tuesday, November 16, 2021 |
| APPL NO | 17/527632 |
| CURRENT CPC | Electric Digital Data Processing G06F 40/30 (20200101) Original (OR) Class Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6262 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220376120 | Meng et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Little Rock, Arkansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiangbo Meng (Fayetteville, Arkansas); Rohith Allaparthi (Fayetteville, Arkansas); Mirsaeid Sarollahi (Fayetteville, Arkansas); Pijush Kanti Ghosh (Dallas, Texas); Morgan Ware (Fayetteville, Arkansas) |
| ABSTRACT | A capacitor is provided for high temperature systems. The capacitor includes: a substrate formed from silicon carbide material; a dielectric stack layer, including a first layer deposited on the substrate and a second layer deposited on the first layer; a Schottky contact layer deposited on the second layer; and an Ohmic contact layer deposited on the substrate. The first layer is formed with aluminum nitride (AlN) epitaxially, and the second layer is formed with aluminum oxide (Al2O3). AlN and Al2O3 are ultrawide band gap materials, and as a result, they can be use as the dielectric in the capacitor, allowing the capacitance changes to be less than 10% between −250° C. and 600° C., which is very effective for the high temperature systems. |
| FILED | Tuesday, May 17, 2022 |
| APPL NO | 17/746027 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/45 (20130101) H01L 29/94 (20130101) Original (OR) Class H01L 29/511 (20130101) H01L 29/518 (20130101) H01L 29/6606 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220376304 | Bolton |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Onas Bolton (Pepper Pike, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Onas Bolton (Pepper Pike, Ohio) |
| ABSTRACT | An electrolyte additive is provided. The additive is a quaternary ammonium or phosphonium salt effective to suppress hydrogen evolution and metal dendrite formation during operation of a zinc electrochemical cell such as a zinc-air battery. A zinc battery cell is also provided, which contains an effective amount of the electrolyte additive. |
| FILED | Thursday, July 14, 2022 |
| APPL NO | 17/864544 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/133 (20130101) H01M 4/244 (20130101) H01M 10/0567 (20130101) Original (OR) Class H01M 12/06 (20130101) H01M 2300/0025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220377084 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fan Zhang (New York, New York); Sai Krishna Deepak Maram (New York, New York); Harjasleen Malvai (Ithaca, New York); Steven Goldfeder (Spring Valley, New York); Ari Juels (New York, New York) |
| ABSTRACT | A verifier device in one embodiment is configured to communicate over one or more networks with a client device and a server device. The verifier device participates in a three-party handshake protocol with the client device and the server device in which the verifier device and the client device obtain respective shares of a session key of a secure session with the server device. The verifier device receives from the client device a commitment relating to the secure session with the server device, and responsive to receipt of the commitment, releases to the client device additional information relating to the secure session that was not previously accessible to the client device. The verifier device verifies correctness of at least one characterization of data obtained by the client device from the server device as part of the secure session, based at least in part on the commitment and the additional information. |
| FILED | Friday, August 28, 2020 |
| APPL NO | 17/636402 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 63/126 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220377560 | ZENG |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF SOUTH CAROLINA (Columbia, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | QIANG ZENG (WEST COLUMBIA, South Carolina) |
| ABSTRACT | Secure pairing is key to trustworthy deployment and application of Internet of Things (IoT) devices. However, IoT devices lack conventional user interfaces, such as keyboards and displays, which make many traditional pairing approaches inapplicable. Proximity-based pairing approaches are very usable, but can be exploited by co-located malicious devices. Approaches based on a user's physical operations on IoT devices are more secure, but typically require inertial sensors, while many devices do not satisfy this requirement. A secure and usable pairing approach that can be applied to heterogeneous IoT devices still does not exist. We develop a technique, Universal Operation Sensing, which allows an IoT device to sense the user's physical operations on it without requiring inertial sensors. With this technique, a user holding a smartphone or wearing a wristband can finish pairing in seconds through some very simple operations, e.g., pressing a button or twisting a knob. Moreover, we reveal an inaccuracy issue in original fuzzy commitment and propose faithful fuzzy commitment to resolve it. We design a pairing protocol using faithful fuzzy commitment, and build a prototype system named Touch-to-Pair (T2Pair, for short). The comprehensive evaluation shows that it is secure and usable. |
| FILED | Thursday, March 10, 2022 |
| APPL NO | 17/691697 |
| CURRENT CPC | Wireless Communication Networks H04W 12/06 (20130101) H04W 12/50 (20210101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20220369664 | KOZUBAL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Fynder Group, Inc. (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark A. KOZUBAL (Bozeman, Montana); Richard E. MACUR (Manhattan, Montana); Yuval C. AVNIEL (Missoula, Montana); Maximilian DeVane HAMILTON (Bozeman, Montana) |
| ABSTRACT | Methods of production of edible filamentous fungal biomat formulations are provided as standalone protein sources and/or protein ingredients in foodstuffs as well as a one-time use or repeated use self-contained biofilm-biomat reactor comprising a container with at least one compartment and placed within the compartment(s), a feedstock, a fungal inoculum, a gas-permeable membrane, and optionally a liquid nutrient medium. |
| FILED | Friday, August 05, 2022 |
| APPL NO | 17/882490 |
| CURRENT CPC | Protein Compositions for Foodstuffs; Working-up Proteins for Foodstuffs; Phosphatide Compositions for Foodstuffs A23J 3/20 (20130101) Original (OR) Class A23J 3/227 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220371718 | Zubrin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Pioneer Astronautics (Lakewood, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Zubrin (Lakewood, Colorado); Mark Berggren (Lakewood, Colorado) |
| ABSTRACT | Gas Replacement System (GRS) produces lighter than air lift gas from ammonia to enable balloon launch and/or to extend the flight durations of balloons. The GRS produces lighter than air lift gas by dissociating all or part of an ammonia supply into a mixture of nitrogen and hydrogen. The GRS can be used to launch balloons from the ground and/or produce gas for airborne balloons to extend their flight duration. In one embodiment, a GRS includes a tank containing ammonia (e.g., liquid ammonia), a reactor, and a controller operable to direct a release of the ammonia from the tank to the reactor. The controller is also operable to direct the reactor to dissociate at least a portion of the ammonia into a lift gas and exhaust the lift gas from the reactor into the balloon for inflation, the lift gas comprising nitrogen and hydrogen. |
| FILED | Friday, May 20, 2022 |
| APPL NO | 17/750120 |
| CURRENT CPC | Lighter-than Air Aircraft B64B 1/40 (20130101) B64B 1/62 (20130101) Original (OR) Class B64B 1/64 (20130101) B64B 1/70 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220375356 | Bateman |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Barron Associates, Inc. (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alec Jacob Devine Bateman (Charlottesville, Virginia) |
| ABSTRACT | Embodiments of a system, device and method improve weather modeling approaches for use by air vehicles to mitigate weather hazards and/or optimize air vehicle operations. Various embodiments collect a set of independent measurements of atmospheric parameters of interest, collect a set of onboard measurements from one or more non-traditional atmospheric sensors onboard an air vehicle, process the collected measurements to identify values of selected atmospheric parameters and generate a model for relating raw sensor outputs from the non-traditional atmospheric sensors to the atmospheric parameters of interest. |
| FILED | Tuesday, May 11, 2021 |
| APPL NO | 17/316914 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 39/024 (20130101) B64C 2201/125 (20130101) Traffic Control Systems G08G 5/0034 (20130101) G08G 5/0039 (20130101) G08G 5/0091 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220375641 | Venneri et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ultra Safe Nuclear Corporation (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paolo Francesco Venneri (Seattle, Washington); Michael John Eades (Seattle, Washington) |
| ABSTRACT | Passive reactivity control technologies that enable reactivity control of a nuclear thermal propulsion (NTP) system with little to no active mechanical movement of circumferential control drums. By minimizing or eliminating the need for mechanical movement of the circumferential control drums during an NTP burn, the reactivity control technologies simplify controlling an NTP reactor and increase the overall performance of the NTP system. The reactivity control technologies mitigate and counteract the effects of xenon, the dominant fission product contributing to reactivity transients. Examples of reactivity control technologies include, employing burnable neutron poisons, tuning hydrogen pressure, adjusting wait time between burn cycles or merging burn cycles, and enhancement of temperature feedback mechanisms. The reactivity control technologies are applicable to low-enriched uranium NTP systems, including graphite composite fueled and tungsten ceramic and metal matrix (CERMET), or any moderated NTP system, such as highly-enriched uranium graphite composite NTP systems. |
| FILED | Tuesday, July 19, 2022 |
| APPL NO | 17/868302 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/408 (20130101) Nuclear Reactors G21C 3/62 (20130101) G21C 5/02 (20130101) G21C 15/08 (20130101) Nuclear Power Plant G21D 5/02 (20130101) Original (OR) Class Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 30/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220376777 | BODE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ATLAS Space Operations, Inc. (Traverse City, Michigan) |
| ASSIGNEE(S) | ATLAS Space Operations, Inc. (Traverse City, Michigan) |
| INVENTOR(S) | Brad Arnold BODE (Pacific Palisades, California); Kyle Stephen POLICH (Los Angeles, California) |
| ABSTRACT | Described herein are systems, methods, media, and devices for generating a satellite program for contacting satellites. In some embodiments, data including one or more targets for accessing a satellite constellation is obtained. Based on the data, a set of representations may be generated and candidate satellite constellation access programs may be determined based on the set of representations. For each program, a first score may be computed for each target to obtain a first set of scores, and a second score may be computed for each first score of the first set of scores to obtain a second set of scores. A satellite constellation access program may be selected from the candidate satellite access programs based on the second set of second scores. |
| FILED | Friday, May 21, 2021 |
| APPL NO | 17/327068 |
| CURRENT CPC | Transmission H04B 7/18513 (20130101) H04B 7/18519 (20130101) H04B 7/18526 (20130101) H04B 7/18539 (20130101) H04B 7/18547 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20220372451 | Eiteman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Georgia Research Foundation, Inc. (Athens, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark Andrew Eiteman (Athens, Georgia); William Chris Moxley (Athens, Georgia) |
| ABSTRACT | Modified bacterial strains are provided. The strains can generate a desired product such as pyruvate and products derived from pyruvate. Methods of generating pyruvate and products derived from pyruvate are also provided. The modified bacterial strains have at least one mutation in a gene coding for proteins in a pyruvate dehydrogenase complex such that the mutation allows a cell to accumulate pyruvate and/or products derived from pyruvate. |
| FILED | Tuesday, April 26, 2022 |
| APPL NO | 17/729120 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0008 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372509 | THOLL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY (Blacksburg, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dorothea THOLL (Blacksburg, Virginia); JASON LANCASTER (Blacksburg, Virginia) |
| ABSTRACT | Described herein are engineered polynucleotides and vectors capable of encoding one or more engineered harlequin and/or brown marmorated stink bug pheromone synthesis enzymes. Also described herein are engineered harlequin and/or brown marmorated stink bug pheromone synthesis enzymes. Also described herein are methods of making modified plants capable of expressing one or more harlequin and/or brown marmorated stink bug pheromone synthesis enzymes. |
| FILED | Friday, August 21, 2020 |
| APPL NO | 17/637627 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0081 (20130101) C12N 9/88 (20130101) C12N 9/90 (20130101) C12N 15/8286 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220372585 | Moon et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Tae Seok Moon (St. Louis, Missouri); Hyojeong Yi (St. Louis, Missouri); Matthew Amrofell (St. Louis, Missouri); Chenggang Xi (St. Louis, Missouri); Austin Rottinghaus (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Tae Seok Moon (St. Louis, Missouri); Hyojeong Yi (St. Louis, Missouri); Matthew Amrofell (St. Louis, Missouri); Chenggang Xi (St. Louis, Missouri); Austin Rottinghaus (St. Louis, Missouri) |
| ABSTRACT | Among the various aspects of the present disclosure is the provision of molecular sensors, microbial sensors, constructs, systems, and methods for selectively detecting aromatic compounds. |
| FILED | Wednesday, April 27, 2022 |
| APPL NO | 17/731195 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/02 (20130101) C12Q 1/6897 (20130101) Original (OR) Class Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/19 (20210501) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/9406 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220374026 | Vougioukas et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Stavros Vougioukas (Davis, California); Chen Peng (Davis, California); Dennis L. Sadowski (Davis, California) |
| ABSTRACT | A system, apparatus and method are provided for robotically assisting the harvest of a crop. Instrumented picker carts include sensors for detecting amounts of harvested crop (e.g., fill ratios) of containers carried by the carts, communication modules for communicating their locations and detected crop amounts to a field computer, and components for signaling for robotic service. The field computer predicts when a cart that requests service will have a full container and where it will be located at that time, then decides whether to approve the request. If the request is approved, a robot is assigned and is given (or generates) a path to the cart's predicted location, and begins moving toward the location so as to arrive near (and preferably before) the predicted time. Robots include means for moving (e.g., wheels, motors, steering components, power sources), navigation modules, computing components for controlling their movement, and communication modules. |
| FILED | Tuesday, May 24, 2022 |
| APPL NO | 17/752335 |
| CURRENT CPC | Harvesting; Mowing A01D 90/16 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/0274 (20130101) G05D 1/0297 (20130101) Original (OR) Class G05D 2201/0201 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/06316 (20130101) G06Q 50/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20220370410 | Garcia |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States Government As Represented By The Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jose M. Garcia (Seattle, Washington) |
| ABSTRACT | Disclosed are methods of treating muscle loss in a subject comprising administering a therapeutically effective amount of a GHSR1a antagonist, a GHSR1a inverse agonist, a ghrelin antagonist, or a decoy ghrelin receptor to a subject in need thereof. Disclosed are methods of inhibiting the binding of ghrelin to GHSR1a (or GHSR1a to ghrelin) in a subject comprising administering a therapeutically effective amount of GHSR1a antagonist, GHSR1a inverse agonist, ghrelin antagonist, or decoy ghrelin receptor to a subject in need thereof. Also disclosed are methods of inhibiting the binding of ghrelin to GHSR1a (or GHSR1a to ghrelin) in a subject comprising mutating GHSR1a. Disclosed are methods of lowering proteasome activity in a subject comprising administering a therapeutically effective amount of a GHSR1a antagonist, a GHSR1a inverse agonist, a ghrelin antagonist, or a decoy ghrelin receptor to a subject in need thereof. Disclosed are methods of enhancing myogenesis in a subject comprising administering a therapeutically effective amount of a GHSR1a antagonist, a GHSR1a inverse agonist, a ghrelin antagonist, or a decoy ghrelin receptor to a subject in need thereof. Disclosed are methods of increasing mitochondrial biogenesis in a subject comprising administering a therapeutically effective amount of a GHSR1a antagonist, a GHSR1a inverse agonist, a ghrelin antagonist, or a decoy ghrelin receptor to a subject in need thereof. |
| FILED | Tuesday, May 24, 2022 |
| APPL NO | 17/752491 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/405 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370415 | Eisner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Kembi Therapeutics Pty Ltd (Carlton, Australia); The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | Kembi Therapeutics Pty Ltd (Carlton, Australia); The Regents of the University of Michigan (Ann Arbor, Michigan); The United States Government as represented by The Department of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | Joel Eisner (Chapel Flill, North Carolina); Daniel Wahl (Ann Arbor, Michigan); Corey Speers (Ann Arbor, Michigan) |
| ABSTRACT | The instant invention describes pharmaceutical compositions and dosing regimens comprising radiation therapy and seviteronel with or without dexamethasone, and methods of treating diseases, disorders or symptoms thereof. |
| FILED | Friday, October 11, 2019 |
| APPL NO | 17/284200 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/573 (20130101) A61K 31/4192 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370566 | Butler et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Saint Louis University (St. Louis, Missouri); U.S.DEPARTMENT OF VETERANS' AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Alistair Butler (St. Louis, Missouri); Susan Farr (St. Louis, Missouri); Clemence Girardet (Paris, France) |
| ABSTRACT | Disclosed are methods and compositions for treating cognitive decline in subjects in need. More specifically, disclosed are methods of administrating exogenous adropin to subjects suffering from, or at risk of, cognitive decline including the aged and those suffering from traumatic brain injury. Also disclosed are subjects who would benefit from such treatment and pharmaceutical acceptable compositions comprising adropin, adropin34-76, and derivatives or variations thereof. |
| FILED | Tuesday, November 12, 2019 |
| APPL NO | 17/614035 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/22 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220370805 | Cogan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duke University (Durham, North Carolina); New York University (, None); U.S. GOVENMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia); University of Utah Research Foundation (Salt Lake City, Utah); BLACKROCK MICROSYSTEMS, LLC dba (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregory Cogan (Durham, North Carolina); Jonathan Viventi (Durham, North Carolina); Nandan Lad (Durham, North Carolina); Bijan Pesaran (New York, New York); Virginia Woods (Durham, North Carolina); Chia-Han Chiang (Durham, North Carolina); Charles Wang (Durham, North Carolina); Katrina Barth (Durham, North Carolina); Werner Doyle (New York, New York); Patricia Dugan (New York, New York); Orrin Devinsky (New York, New York); Sasha Devore (New York, New York); Daniel Friedman (New York, New York); Amy Orsborn (New York, New York); Florian Solzbacher (Salt Lake City, Utah); Robert Franklin (Salt Lake City, Utah); Sandeep Negi (Salt Lake City, Utah); Saket Mulge (Salt Lake City, None) |
| ABSTRACT | The present disclosure provides systems and methods related to electroencephalography (EEG) electrode arrays. In particular, the present disclosure provides systems and methods relating to the manufacture and use of high-resolution electrocorticography (ECOG) electrode arrays and stereoelectroencephalography (SEEG) electrode arrays having various combinations and arrangements of microelectrodes and macroelectrodes for recording and modulating nervous system activity. |
| FILED | Friday, September 18, 2020 |
| APPL NO | 17/761369 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/36064 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20220369664 | KOZUBAL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Fynder Group, Inc. (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark A. KOZUBAL (Bozeman, Montana); Richard E. MACUR (Manhattan, Montana); Yuval C. AVNIEL (Missoula, Montana); Maximilian DeVane HAMILTON (Bozeman, Montana) |
| ABSTRACT | Methods of production of edible filamentous fungal biomat formulations are provided as standalone protein sources and/or protein ingredients in foodstuffs as well as a one-time use or repeated use self-contained biofilm-biomat reactor comprising a container with at least one compartment and placed within the compartment(s), a feedstock, a fungal inoculum, a gas-permeable membrane, and optionally a liquid nutrient medium. |
| FILED | Friday, August 05, 2022 |
| APPL NO | 17/882490 |
| CURRENT CPC | Protein Compositions for Foodstuffs; Working-up Proteins for Foodstuffs; Phosphatide Compositions for Foodstuffs A23J 3/20 (20130101) Original (OR) Class |