FedInvent™ Patent Applications

Application Details for Thursday, November 24, 2022 

This page was updated on Wednesday, November 30, 2022 at 12:38 PM GMT

Department of Health and Human Services (HHS) 

US 20220369610 Wiles et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
NIH Office of the Director (NIHOD)
APPLICANT(S) The Jackson Laboratory (Bar Harbor, Maine)
ASSIGNEE(S) The Jackson Laboratory (Bar Harbor, Maine)
INVENTOR(S) Michael V. Wiles (Bar Harbor, Maine);  Benjamin E. Low (Bar Harbor, Maine)
ABSTRACT The present disclosure provides methods and compositions for high frequency mouse transgenesis using, for example, a Bxb1 landing pad.
FILED Thursday, October 08, 2020
APPL NO 17/767311
CURRENT CPC
Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals
A01K 67/0278 (20130101) Original (OR) Class
A01K 2207/15 (20130101)
A01K 2217/072 (20130101)
A01K 2227/105 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/907 (20130101)
C12N 2310/20 (20170501)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220369933 Wang et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
ASSIGNEE(S)
INVENTOR(S) Thomas D. Wang (Ann Arbor, Michigan);  Xiyu Duan (San Jose, California);  Haijun LI (Ann Arbor, Michigan)
ABSTRACT An optical probe assembly as a confocal endomicroscope includes an optical focusing stage that focuses an output beam onto a sample and a mirror scanning stage that is movable for scanning the output beam in both a lateral two dimensional plane and an axial direction, using a side-view configuration. The side-view configuration allows for output beam illumination and fluorescent imaging of the sample with greater imaging resolution and improved access to hard to reach tissue within a subject.
FILED Tuesday, July 24, 2018
APPL NO 16/633483
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 1/07 (20130101)
A61B 1/043 (20130101)
A61B 1/00096 (20130101)
A61B 1/00172 (20130101)
A61B 1/00177 (20130101)
A61B 1/00193 (20130101)
A61B 1/0623 (20130101)
A61B 1/0638 (20130101)
A61B 5/0068 (20130101) Original (OR) Class
A61B 5/0071 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220369997 Kraus et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
APPLICANT(S) Northwestern University (Evanston, Illinois);  Trustees of Dartmouth College (Hanover, New Hampshire)
ASSIGNEE(S)
INVENTOR(S) Nina Kraus (Evanston, Illinois);  Jay C. Buckey (Hanover, New Hampshire);  Abigail M. Fellows (Hanover, New Hampshire);  Jennifer L. Krizman (Glencoe, Illinois);  Trent G. Nicol (Libertyville, Illinois);  Catherine C. Rieke (Hanover, New Hampshire);  Travis White-Schwoch (Evanston, Illinois)
ABSTRACT Central nervous (“CNS”) health in subjects who have human immunodeficiency virus (“HIV”) or non-human-species analogs thereof is 102 evaluated or otherwise monitored by analyzing frequency following response (“FFR”). In general, one or more components of an FFR are analyzed, The FFR is measured in response to the administration of an acoustic stimulus to the subject. The acoustic stimulus includes a complex sound, which may include a consonant and a consonant-to-vowel transition. An indication of CNS health can be generated by measuring changes in the FFR components (e.g., over time or relative to normative data).
FILED Monday, June 08, 2020
APPL NO 17/596217
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/38 (20210101)
A61B 5/291 (20210101)
A61B 5/374 (20210101)
A61B 5/4058 (20130101) Original (OR) Class
A61B 2503/40 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370004 Lue et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
APPLICANT(S) Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center (Torrance, California);  The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) YanHe Lue (Torrance, California);  Boris Hyle Park (Torrance, California);  Ronald Swerdloff (Torrance, California);  Jacob Rajfer (Torrance, California);  Christina Wang (Torrance, California);  Junze Liu (Torrance, California)
ABSTRACT Aspects of the methods include volumetrically imaging testicular tissue by optical coherence tomography to identify a testicular tissue location that is likely to contain sperm; and m-mode scanning using optical coherence tomography the identified testicular location to determine whether sperm are at least likely to be present at the location. Methods may further include harvesting sperm from the location, e.g., for use in in vitro fertilization. Also provided are devices and systems for practicing the methods.
FILED Thursday, February 24, 2022
APPL NO 17/679516
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/0066 (20130101)
A61B 5/4387 (20130101) Original (OR) Class
A61B 10/0058 (20130101)
A61B 17/43 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370017 DeMazumder et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Non-Profit Organization (NPO)
American Heart Association (AHA)
APPLICANT(S) University of Cincinnati (Cincinnati, Ohio)
ASSIGNEE(S) University of Cincinnati (Cincinnati, Ohio)
INVENTOR(S) Deeptankar DeMazumder (Baltimore, Maryland);  Benjamin Vaughan (Cincinnati, Ohio)
ABSTRACT Provided herein is a method for diagnosing and treating a subject at risk for atrial fibrillation (AF) or related health conditions, the method including: collecting one or more physiological signals from the subject in a sleep state or an awake state; extracting time series data from the one or more physiological signals; performing dynamic analyses of the time series data using artificial intelligence, wherein the artificial intelligence calculates a series of dynamic measurements, said dynamic measurements being indicative of a probability of an onset of an abnormal atrial rhythm; providing an integrated personalized risk score including the dynamic measurements, wherein the integrated personalized risk score is indicative of a probability of an onset of AF in the subject; diagnosing the subject as being at risk for AF when the integrated personalized risk score exceeds a threshold value, wherein the threshold value is calculated by the artificial intelligence based on a library of stored data; and treating the diagnosed subject with an effective therapy to prevent or treat AF or AF-related health conditions.
FILED Monday, May 16, 2022
APPL NO 17/745690
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/0205 (20130101)
A61B 5/318 (20210101)
A61B 5/02405 (20130101)
A61B 5/4806 (20130101)
A61B 5/7275 (20130101) Original (OR) Class

Preparations for Medical, Dental, or Toilet Purposes
A61K 31/7048 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 9/06 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370033 Klingensmith et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) Board of Trustees of Southern Illinois University (Edwardsville, Illinois)
ASSIGNEE(S)
INVENTOR(S) Jon Klingensmith (Carbondale, Illinois);  Colin Gibbons (Glen Carbon, Illinois);  Michaela Kulasekara (Glen Carbon, Illinois)
ABSTRACT A system for patient cardiac imaging and tissue modeling. The system includes a patient imaging device that can acquire patient cardiac imaging data. A processor is configured to receive the cardiac imaging data. A user interface and display allow a user to interact with the cardiac imaging data. The processor includes fat identification software conducting operations to interact with a trained learning network to identify fat tissue in the cardiac imaging data and to map fat tissue onto a three-dimensional model of the heart. A preferred system uses an ultrasound imaging device as the patient imaging device. Another preferred system uses an MRI or CT image device as the patient imaging device.
FILED Wednesday, April 27, 2022
APPL NO 17/730380
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/7275 (20130101)
A61B 8/085 (20130101) Original (OR) Class
A61B 8/0858 (20130101)
A61B 34/10 (20160201)
A61B 2034/105 (20160201)

Image Data Processing or Generation, in General
G06T 7/0012 (20130101)
G06T 2207/30048 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370074 Goldie et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) Vivonics, Inc. (Bedford, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) James H. Goldie (Lexington, Massachusetts);  Brendan LaBrecque (Middleton, Massachusetts);  Anna M. Galea (Stow, Massachusetts);  Eric Klem (Lexington, Massachusetts);  Thomas Doyle (Brentwood, Tennessee);  Ian Cohen (Broomfield, Colorado);  Tim Robinson (Sandown, New Hampshire);  Dana Janssen (Brentwood, Tennessee);  George Nicholson (Nashville, Tennessee)
ABSTRACT A pulmonary artery flow restrictor system includes a funnel shaped membrane with a proximal base, a restrictive distal opening which is stretchable to larger sizes, an internal strut structure, and an external stent structure.
FILED Tuesday, June 07, 2022
APPL NO 17/834351
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 17/12036 (20130101) Original (OR) Class
A61B 17/12109 (20130101)
A61B 17/12172 (20130101)
A61B 17/12177 (20130101)
A61B 2017/12054 (20130101)

Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits
A61F 2/82 (20130101)
A61F 2002/068 (20130101)

Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor
A61M 29/02 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370086 Szafron et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Lawrence Livermore National Laboratory (LLNL)
Federally Funded Research and Development Center (FFRDC)
Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) Lawrence Livermore National Security, LLC (Livermore, California);  The Texas A and M University System (College Statin, Texas)
ASSIGNEE(S)
INVENTOR(S) Jason Szafron (Hamden, Connecticut);  Duncan Maitland (College Station, Texas);  Ward Small, IV (Livermore, California);  Patrick R. Buckley (Livermore, California);  Andrea D. Muschenborn (Bloomington, Indiana)
ABSTRACT An embolectomy device comprised of an expansion unit and a support unit is disclosed. The expansion unit can be actuated in response to one or more external stimuli, and the support unit, located proximately to the expansion unit, provides a force to hold the expansion unit in place and to further induce the expansion unit's radial expansion. The radial expansion of the expansion unit causes the expansion unit to physically contact a blood clot, enabling the blood clot to be removed. In some embodiments, the expansion unit can be fabricated from a shape memory polymer foam. In some embodiments the support unit can be fabricated from any elastic material including, without limitation, shape memory alloys.
FILED Friday, August 05, 2022
APPL NO 17/881684
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 17/22 (20130101) Original (OR) Class
A61B 2017/2212 (20130101)
A61B 2017/22094 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370154 KRISHNASWAMY et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire)
ASSIGNEE(S)
INVENTOR(S) Venkataramanan KRISHNASWAMY (Lebanon, New Hampshire);  Richard J. BARTH, Jr. (Hanover, New Hampshire);  Keith D. PAULSEN (Hanover, New Hampshire)
ABSTRACT A method for guiding resection of local tissue from a patient includes generating at least one image of the patient, automatically determining a plurality of surgical guidance cues indicating three-dimensional spatial properties associated with the local tissue, and generating a visualization of the surgical guidance cues relative to the surface. A system for generating surgical guidance cues for resection of a local tissue from a patient includes a location module for processing at least one image of the patient to determine three-dimensional spatial properties of the local tissue, and a surgical cue generator for generating the surgical guidance cues based upon the three-dimensional spatial properties. A patient-specific locator form for guiding resection of local tissue from a patient includes a locator form surface matching surface of the patient, and a plurality of features indicating a plurality of surgical guidance cues, respectively.
FILED Monday, July 25, 2022
APPL NO 17/872606
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 34/10 (20160201)
A61B 34/20 (20160201) Original (OR) Class
A61B 34/25 (20160201)
A61B 90/361 (20160201)
A61B 2017/008 (20130101)

Image Data Processing or Generation, in General
G06T 7/0012 (20130101)
G06T 7/33 (20170101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370310 KELLER et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Tobias KELLER (Holziken, Switzerland);  Tanja BUDDE (Brittnau, Switzerland);  Samuel RENTSCH (Spiegel bei Bern, Switzerland)
ABSTRACT The present application is related to cancer immunotherapy, e.g. stimulation of T cell mediated anti-tumor therapy. Accordingly, described herein are methods of inducing or enhancing an adaptive immune response to a cancer in a subject and methods of treating cancer in a subject. In some embodiments, the methods hyperactivate dendritic cells (DCs), which induce T helper type I (TH1) and cytotoxic T lymphocyte (CTL) responses in the absence of TH2 immunity.
FILED Wednesday, April 22, 2020
APPL NO 17/605160
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 8/19 (20130101) Original (OR) Class
A61K 8/21 (20130101)
A61K 8/0241 (20130101)
A61K 2800/92 (20130101)

Specific Use of Cosmetics or Similar Toilet Preparations
A61Q 11/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370325 MA et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio)
ASSIGNEE(S) OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio)
INVENTOR(S) Jianjie MA (POWELL, Ohio);  Jianjun GUAN (WILDWOOD, Missouri);  Haichang LI (DUBLIN, Ohio);  Hong NIU (ST. LOUIS, Missouri);  Ya GUAN (CLAYTON, Missouri);  Tao TAN (COLUMBUS, Ohio)
ABSTRACT Cosmeceutical compositions for and methods of improving the appearance of skin and promoting hair growth are provided. Said compositions comprise at least one ROS-scavenging polymer gel, at least MG53, or a combination thereof. A novel boronate ester-based copolymer forms an aqueous hydrogel exhibiting lower viscosity at cooler temperatures and higher viscosity at higher temperatures is provided.
FILED Friday, July 22, 2022
APPL NO 17/871412
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 8/27 (20130101)
A61K 8/042 (20130101)
A61K 8/64 (20130101) Original (OR) Class
A61K 8/8129 (20130101)

Specific Use of Cosmetics or Similar Toilet Preparations
A61Q 7/00 (20130101)
A61Q 19/005 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370371 Hanes et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute on Drug Abuse (NIDA)
APPLICANT(S) The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S)
INVENTOR(S) Justin Hanes (Baltimore, Maryland);  Barbara S. Slusher (Baltimore, Maryland);  Anne Le (Baltimore, Maryland);  Jie Fu (Baltimore, Maryland);  Qingguo Xu (Baltimore, Maryland);  Takashi Tsukamoto (Baltimore, Maryland)
ABSTRACT Currently available glutaminase inhibitors are generally poorly soluble, metabolically unstable, and/or require high doses, which together reduce their efficacy and therapeutic index. These can be formulated into nanoparticles and delivered safely and effectively for treatment of pancreatic cancer and other glutamine addicted cancers. Studies demonstrate that nanoparticle delivery of BPTES, relative to use of BPTES alone, can be safely administered and provides dramatically improved tumor drug exposure, resulting in greater efficacy. GLS inhibitors can be administered in higher concentrations with sub-100 nm nanoparticles, since the nanoparticles package the drug into “soluble” colloidal nanoparticles, and the nanoparticles deliver higher drug exposure selectively to the tumors due to the enhanced permeability and retention (EPR) effect. These factors result in sustained drug levels above the IC50 within the tumors for days, providing significantly enhanced efficacy compared to unencapsulated drug.
FILED Monday, December 06, 2021
APPL NO 17/543450
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0019 (20130101)
A61K 9/5146 (20130101)
A61K 9/5153 (20130101) Original (OR) Class
A61K 31/337 (20130101)
A61K 31/433 (20130101)
A61K 45/06 (20130101)

Heterocyclic Compounds
C07D 285/135 (20130101)
C07D 417/12 (20130101)
C07D 417/14 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370386 Chandraratna et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Complementary and Integrative Health (NCCIH)
National Cancer Institute (NCI)
APPLICANT(S) Io Therapeutics, Inc. (Spring, Texas);  Trustees of Dartmouth College (Hanover, New Hampshire)
ASSIGNEE(S)
INVENTOR(S) Roshantha A. Chandraratna (San Juan Capistrano, California);  Ethan Dmitrovsky (Hanover, New Hampshire);  Elizabeth Nowak (West Lebanon, New Hampshire);  Randolph Noelle (Plainfield, New Hampshire);  Martin E. Sanders (Spring, Texas)
ABSTRACT The present specification provides RXR agonists with both remyelination promotion and immunomodulatory activities, compositions comprising such RXR agonists, and methods using such compounds and compositions to treat a demyelination-related disorder by both promoting remyelination of neurons and modulating the immune system.
FILED Thursday, July 07, 2022
APPL NO 17/859743
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/47 (20130101)
A61K 31/192 (20130101) Original (OR) Class
A61K 31/216 (20130101)
A61K 31/343 (20130101)
A61K 31/353 (20130101)
A61K 31/4704 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370388 Colonna et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute on Aging (NIA)
APPLICANT(S) Washington University (St. Louis, Missouri)
ASSIGNEE(S)
INVENTOR(S) Marco Colonna (St. Louis, Missouri);  Tyler Ulland (St. Louis, Missouri)
ABSTRACT The present disclosure is directed to a method for treating a microglial dysfunction-associated neurodegenerative disease in a subject in need thereof. The method includes administering to the subject a therapeutically effective amount of a composition comprising a microglia receptor agonist that directly activates SYK.
FILED Tuesday, June 14, 2022
APPL NO 17/840368
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/195 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/28 (20180101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6827 (20130101)
C12Q 1/6883 (20130101)
C12Q 2600/156 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370406 Rush
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Drug Abuse (NIDA)
APPLICANT(S) University of Kentucky Research Foundation (Lexington, Kentucky)
ASSIGNEE(S)
INVENTOR(S) Craig R. Rush (Lexington, Kentucky)
ABSTRACT Combinations and methods for treating a subject experiencing or at risk of experiencing an undesired consequence of stimulant use are provided. The combinations include topiramate and phentermine. The methods include administering an effective dose of a combination of topiramate and phentermine to a subject. In some embodiments, the methods include administering an effective dose of a combination of topiramate and phentermine to a subject with cocaine use disorder.
FILED Wednesday, August 03, 2022
APPL NO 17/880101
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/137 (20130101)
A61K 31/357 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/30 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370408 MOR
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York)
ASSIGNEE(S)
INVENTOR(S) ADAM MOR (Cresskill, New Jersey)
ABSTRACT Exemplary methods, compositions, kits and uses thereof for treating neoplasia are provided. For example, a method can be provided for treating neoplasia in a subject, including administering to the subject a VRK2 (vaccinia-related kinase 2) inhibitor, alone or in combination with an inhibitor of Programmed cell death receptor-1 (PD-1). The exemplary methods, compositions and kits may improve cancer immunotherapy.
FILED Thursday, April 21, 2022
APPL NO 17/726120
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/381 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6886 (20130101)
C12Q 2600/136 (20130101)
C12Q 2600/158 (20130101)
C12Q 2600/178 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370410 Garcia
FUNDED BY
Department of Veterans Affairs (DVA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
APPLICANT(S) The United States Government As Represented By The Department of Veterans Affairs (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Jose M. Garcia (Seattle, Washington)
ABSTRACT Disclosed are methods of treating muscle loss in a subject comprising administering a therapeutically effective amount of a GHSR1a antagonist, a GHSR1a inverse agonist, a ghrelin antagonist, or a decoy ghrelin receptor to a subject in need thereof. Disclosed are methods of inhibiting the binding of ghrelin to GHSR1a (or GHSR1a to ghrelin) in a subject comprising administering a therapeutically effective amount of GHSR1a antagonist, GHSR1a inverse agonist, ghrelin antagonist, or decoy ghrelin receptor to a subject in need thereof. Also disclosed are methods of inhibiting the binding of ghrelin to GHSR1a (or GHSR1a to ghrelin) in a subject comprising mutating GHSR1a. Disclosed are methods of lowering proteasome activity in a subject comprising administering a therapeutically effective amount of a GHSR1a antagonist, a GHSR1a inverse agonist, a ghrelin antagonist, or a decoy ghrelin receptor to a subject in need thereof. Disclosed are methods of enhancing myogenesis in a subject comprising administering a therapeutically effective amount of a GHSR1a antagonist, a GHSR1a inverse agonist, a ghrelin antagonist, or a decoy ghrelin receptor to a subject in need thereof. Disclosed are methods of increasing mitochondrial biogenesis in a subject comprising administering a therapeutically effective amount of a GHSR1a antagonist, a GHSR1a inverse agonist, a ghrelin antagonist, or a decoy ghrelin receptor to a subject in need thereof.
FILED Tuesday, May 24, 2022
APPL NO 17/752491
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/405 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 21/00 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370416 Chu et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Arvinas Operations, Inc. (New Haven, Connecticut);  Yale University (New Haven, Connecticut)
ASSIGNEE(S)
INVENTOR(S) Ling Chu (Anhui, China PRC);  Craig M. Crews (New Haven, Connecticut);  Hanqing Dong (Madison, Connecticut);  Keith R. Hornberger (Southbury, Connecticut);  Jesus Raul Medina (Gilbertsville, Pennsylvania);  Lawrence Snyder (Killingworth, Connecticut);  Jing Wang (Milford, Connecticut)
ABSTRACT Bifunctional compounds, which find utility as modulators of Kirsten ras sarcoma protein (KRas or KRAS), are described herein. In particular, the hetero-bifunctional compounds of the present disclosure contain on one end a moiety that binds to the Von Hippel-Lindau E3 ubiquitin ligase and on the other end a moiety which binds KRas, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The hetero-bifunctional compounds of the present disclosure exhibit a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aberrant regulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.
FILED Tuesday, April 06, 2021
APPL NO 17/223551
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/422 (20130101)
A61K 31/427 (20130101) Original (OR) Class
A61K 31/4155 (20130101)
A61K 45/06 (20130101)
A61K 47/545 (20170801)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370434 Chen et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) City of Hope (Duarte, California)
ASSIGNEE(S)
INVENTOR(S) Jianjun Chen (Temple City, California);  Rui Su (Monrovia, California);  David Horne (Duarte, California);  Xiaolan Deng (Temple City, California);  Hongzhi Li (Duarte, California);  Jun Xie (Duarte, California)
ABSTRACT Provided, inter alia, are methods and compositions for treating FTO-mediated cancer.
FILED Thursday, July 23, 2020
APPL NO 17/627059
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/47 (20130101) Original (OR) Class
A61K 31/473 (20130101)
A61K 31/495 (20130101)
A61K 31/497 (20130101)
A61K 31/704 (20130101)
A61K 31/4178 (20130101)
A61K 31/7068 (20130101)
A61K 45/06 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/02 (20180101)

Heterocyclic Compounds
C07D 215/52 (20130101)
C07D 219/04 (20130101)
C07D 233/52 (20130101)
C07D 403/14 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370463 Park-Min
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S) New York Society for the Relief of the Ruptured and Crippled, Maintaining the Hospital for Special S (New York, New York)
ASSIGNEE(S)
INVENTOR(S) Kyung-Hyun Park-Min (Fort Lee, New Jersey)
ABSTRACT Provided herein is a method of treating bone resorption associated with osteoclastic activity in a subject in need thereof. The method includes reducing the level of FMS intracellular fragments (FICDs) in the subject.
FILED Friday, September 18, 2020
APPL NO 17/761027
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/52 (20130101) Original (OR) Class
A61K 31/4439 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/6863 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370464 Hussein et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) Microbiotix, Inc. (Worcester, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Islam Hussein (Marlboro, Massachusetts);  Terry L. Bowlin (Maineville, Ohio);  Richard Gauthier (Montreal, Canada)
ABSTRACT The present invention is related to therapeutics and prophylactics for the treatment and/or prevention of ocular viral infections in humans and other mammals. Disclosed are methods of treating or preventing ocular viral infections in mammals, in particular caused by adenoviral infections, by administration of an effective amount of filociclovir (FCV).
FILED Wednesday, June 24, 2020
APPL NO 17/622613
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/08 (20130101)
A61K 9/0048 (20130101)
A61K 31/522 (20130101) Original (OR) Class
A61K 47/10 (20130101)
A61K 47/44 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/12 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370471 Du
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
APPLICANT(S) BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
ASSIGNEE(S) BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
INVENTOR(S) Heng Du (Richardson, Texas)
ABSTRACT Hippocampal lesions, including synaptic failure, are a defining pathology of Alzheimer's disease (AD). However, the molecular mechanisms that underlie hippocampal synaptic injury in this neurodegenerative disorder have yet not been fully elucidated. In Current therapeutic efforts for the treatment of AD are not effective in correcting hippocampal synaptic deficits. It is disclosed that the interaction with amyloid beta (Aβ) induces dysfunction of growth hormone secretagogue receptor 1a (GHSR1α; ghrelin receptor), leading to suppressed GHSR1α regulation of hippocampal dopamine receptor D1 (DRD1) in AD hippocampi. The modulation of DRD1 by GHSR1α impacts hippocampal synaptic plasticity. The simultaneous application of a selective GHSR1α agonist and a selective DRD1 agonist mitigates Aβ-induced hippocampal synaptic injury and improves spatial memory in AD mouse models. These data reveal a novel mechanism of hippocampal vulnerability in AD and that the combined activation of GHSR1α and DRD1 provides a new avenue for the pharmaceutical treatment of AD.
FILED Thursday, August 13, 2020
APPL NO 17/634850
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/55 (20130101) Original (OR) Class
A61K 31/438 (20130101)
A61K 45/06 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/28 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370479 TONKS et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) COLD SPRING HARBOR LABORATORY (Cold Spring Harbor, New York);  DEPYMED, INC. (Farmingdalge, New York)
ASSIGNEE(S) COLD SPRING HARBOR LABORATORY (Cold Spring Harbor, New York);  DEPYMED, INC. (Farmingdale, New York)
INVENTOR(S) Nicholas TONKS (Cold Spring Harbor, New York);  Navasona KRISHNAN (Hawthorn Woods, Illinois);  Andreas GRILL (Farmingdale, New York);  Howard SARD (Woburn, Massachusetts)
ABSTRACT Provided is a method of forming a copper-containing complex, including contacting a sample containing copper with a compound of Formula I: wherein R is —OH or —O—CH3. Also provided is a method of inhibiting enzymatic activity of a kinase in a sample, including contacting the sample with a compound of Formula I. Further provided is a method of administering to a subject a pharmaceutical composition including a compound of Formula I optionally complexed with copper. Also provided is a pharmaceutical composition including copper complexed with a compound of Formula I.
FILED Monday, July 18, 2022
APPL NO 17/866724
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/58 (20130101) Original (OR) Class
A61K 31/4184 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370486 Burke et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) The Board of Trustees of the University of Illinois (Urbana, Illinois)
ASSIGNEE(S)
INVENTOR(S) Martin D. Burke (Champaign, Illinois);  Chad M. Rienstra (Sun Prairie, Wisconsin);  Jiabao Zhang (Urbana, Illinois)
ABSTRACT Disclosed are compositions comprising a polyene macrolide antibiotic and an azole antifungal, and packaged pharmaceutical products comprising the disclosed compositions. Also disclosed are methods of treating systemic fungal infections comprising co-administering to a mammal a polyene macrolide antibiotic and an azole antifungal (conjoint administration). The co-administration may be simultaneous (e.g., in a single formulation or in separate formulations), sequential, or staggered.
FILED Friday, August 07, 2020
APPL NO 17/633327
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0019 (20130101)
A61K 31/425 (20130101)
A61K 31/4164 (20130101)
A61K 31/7042 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/10 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370488 Suk et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Eye Institute (NEI)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S)
INVENTOR(S) Jung Soo Suk (Baltimore, Maryland);  Yoo Chun Kim (Baltimore, Maryland);  Justin Hanes (Baltimore, Maryland)
ABSTRACT Mucus penetrating nanoparticles for inducing, increasing, or enhancing an immune response typically include core of a blend of a biodegradable hydrophobic polymer and a hydrophilic polymer, wherein ≥50% of the biodegradable polymer is conjugated to the hydrophilic polymer, and the hydrophilic polymers forms a coating on the particle. The particles encapsulate a cargo, typically an antigen, adjuvant or other immunomodulator, or a nucleic acid encoding the antigen, or combination thereof. Pharmaceutical compositions including an effective amount of particles to induce an immune response in a subject in need thereof are also provided. Methods of inducing an immune response are also provided, and typically include administering to a subject, preferably via the respiratory tract, the pharmaceutical composition. In some embodiments, the subject has cancer or an infection of the lung.
FILED Wednesday, October 21, 2020
APPL NO 17/770437
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0034 (20130101)
A61K 9/0053 (20130101)
A61K 9/5107 (20130101)
A61K 31/711 (20130101) Original (OR) Class
A61K 47/6935 (20170801)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370490 Mirkin et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) NORTHWESTERN UNIVERSITY (Evanston, Illinois)
ASSIGNEE(S)
INVENTOR(S) Chad A. Mirkin (Wilmette, Illinois);  Ziyin Huang (Evanston, Illinois);  Lisa Cole (Chicago, Illinois);  Cassandra Elizabeth Callmann (Evanston, Illinois);  Shuya Wang (Evanston, Illinois)
ABSTRACT The present disclosure is generally directed to spherical nucleic acids (SNAs) comprising multiple TLR agonists that enable the simultaneous activation of multiple TLR pathways for maximally synergistic immune activation. In some aspects, the present disclosure provides a spherical nucleic acid (SNA) comprising: (a) a nanoparticle core; (b) one or more toll-like receptor 3 (TLR3) agonists encapsulated in the nanoparticle core; and (c) a shell of oligonucleotides attached to the external surface of the nanoparticle core, the shell of oligonucleotides comprising one or more toll-like receptor 9 (TLR9) agonist oligonucleotides. Methods of using the SNAs are also provided herein.
FILED Friday, May 20, 2022
APPL NO 17/749977
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/1275 (20130101)
A61K 31/713 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 37/04 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370507 YOON et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) EMORY UNIVERSITY (Atlanta, Georgia)
ASSIGNEE(S)
INVENTOR(S) Young-Sup YOON (Atlanta, Georgia);  Young-Doug SOHN (Atlanta, Georgia);  Sang-Ho LEE (Atlanta, Georgia)
ABSTRACT This disclosure relates to endothelial and smooth muscle like vascular tissue produced from urine cells. In certain embodiments, the disclosure relates to methods of producing endothelial and smooth muscle like vascular tissue by exposing urine derived cells with ETV2 in a first growth media under conditions such that the cells are modified to form a pool of cells expressing increased levels of endothelium surface markers and thereafter exposing the pool of cells to a second growth media under conditions such that the cells are modified to form tissue containing cells expressing increased levels of smooth muscle surface markers in addition to the endothelium surface markers. In certain embodiments, the disclosure relates to using cells and tissues reported herein for the treatment of vascular, cardiac, and wound healing indications.
FILED Friday, July 10, 2020
APPL NO 17/761876
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/44 (20130101) Original (OR) Class

Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 27/3625 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0691 (20130101)
C12N 2500/32 (20130101)
C12N 2500/34 (20130101)
C12N 2500/38 (20130101)
C12N 2500/46 (20130101)
C12N 2501/11 (20130101)
C12N 2501/39 (20130101)
C12N 2501/91 (20130101)
C12N 2501/115 (20130101)
C12N 2501/165 (20130101)
C12N 2506/25 (20130101)
C12N 2513/00 (20130101)
C12N 2710/10343 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370547 Pamer et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) MEMORIAL SLOAN-KETTERING CANCER CENTER (New York, New York)
ASSIGNEE(S) MEMORIAL SLOAN-KETTERING CANCER CENTER (New York, New York)
INVENTOR(S) Eric Pamer (Montclair, New Jersey);  Sohn Kim (New York, New York);  Peter McKenney (New York, New York);  Silvia Caballero (Cambridge, Massachusetts)
ABSTRACT The present disclosure relates to novel lantibiotics, lantibiotic pharmaceutical compositions, isolated and recombinant lantibiotic-producing bacteria, bacterial pharmaceutical compositions, methods of producing novel lantibiotics from lantibiotic-producing bacteria, and methods of using such lantibiotics, lantibiotic pharmaceutical compositions, and bacterial pharmaceutical compositions to treat gram-positive bacteria infections, including vancomycin resistant enterococci infections, in patients, and to treat food and other objects to avoid gram-positive bacteria contamination.
FILED Tuesday, December 28, 2021
APPL NO 17/563772
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/12 (20130101) Original (OR) Class
A61K 38/443 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/04 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 1/20 (20130101)

Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture
C12P 21/00 (20130101)

Enzymes
C12Y 101/0112 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370552 Bix
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) University of Kentucky Research Foundation (Lexington, Kentucky)
ASSIGNEE(S)
INVENTOR(S) Gregory J. Bix (Lexington, Kentucky)
ABSTRACT The present invention relates to methods for enhancing recovery after an ischemic injury, including cerebral ischemia and stroke, by administration of therapeutic amounts of Domain V protein.
FILED Friday, July 29, 2022
APPL NO 17/877378
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0019 (20130101)
A61K 38/1709 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/28 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370553 RONAI et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Sanford Burnham Prebys Medical Discovery Institute (La Jolla, California)
ASSIGNEE(S)
INVENTOR(S) Ze'ev A. RONAI (Fallbrook, California);  Scott PETERSON (Escondido, California);  Yan LI (San Diego, California)
ABSTRACT Described herein are methods and compositions for treating, reducing, or ameliorating cancer in a subject, comprising administering compositions comprising mucin and/or inulin. In some aspects, described herein is a method of enhancing anti-cancer immunity comprising: (a) administering to a subject a composition comprising mucin, wherein the subject has been identified as having a gut microbiome comprising one more microbial taxa that are members of a Clostridium cluster XIVa or an Actinobacteria phylum; and (b) altering the gut microbiome in the subject, wherein administration of the composition causes an enhanced anti-cancer immunity in the subject.
FILED Thursday, July 30, 2020
APPL NO 17/627558
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/733 (20130101)
A61K 38/1735 (20130101) Original (OR) Class
A61K 45/06 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370557 ESPINO et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of General Medical Sciences (NIGMS)
National Institute on Minority Health and Health Disparities (NIMHD)
APPLICANT(S) UNIVERSITY OF PUERTO RICO (San Juan, Puerto Rico)
ASSIGNEE(S)
INVENTOR(S) Ana M. ESPINO (San Juan, Puerto Rico);  Jose J. ROSADO-FRANCO (San Juan, Puerto Rico)
ABSTRACT The present disclosure reports that (1) recombinant Fh15 significantly prevented bacteremia, suppressed LPS levels in plasma and the production of C-reactive protein and procalcitonin, which are key signatures of inflammation and bacterial infection, respectively; (2) reduced the production of pro-inflammatory cytokines; and (3) increased innate immune cell populations in blood, which suggests a role in promoting a prolonged steady state in rhesus macaques even in the presence of inflammatory stimuli. This is the first report demonstrating that a F. hepatica-derived molecule possesses potential as anti-inflammatory drug against sepsis in an NHP-model. Prophylactic effects of rFh15 administered in a non-human preclinical primate model of sepsis support its use as a biotherapeutic.
FILED Thursday, June 16, 2022
APPL NO 17/842599
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/1767 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/04 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370560 Wang et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S) The Regents of the University of Colorado, A Body Corporate (Denver, Colorado)
ASSIGNEE(S)
INVENTOR(S) Xiao-Jing Wang (Greenwood Village, Colorado);  Qinghong Zhang (Englewood, Colorado);  Yosef Refaeli (Denver, Colorado)
ABSTRACT The present technology provides methods and compositions for the treatment of inflammatory and/or tissue damage conditions. In particular, the use of Smad7 compositions delivered locally or systemically to a site of inflammation and/or tissue damage is described. Other specific embodiments concern treatment or prevention of side effects caused by radiation and/or chemotherapy, including but not limited to oral and gastric mucositis. Also provided are codon-optimized nucleic acids encoding for Smad7 fusion proteins.
FILED Friday, April 22, 2022
APPL NO 17/727579
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/18 (20130101) Original (OR) Class
A61K 38/162 (20130101)
A61K 48/005 (20130101)

Peptides
C07K 14/005 (20130101)
C07K 14/475 (20130101)
C07K 14/4702 (20130101)
C07K 14/4703 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 7/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370566 Butler et al.
FUNDED BY
Department of Veterans Affairs (DVA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) Saint Louis University (St. Louis, Missouri);  U.S.DEPARTMENT OF VETERANS' AFFAIRS (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Andrew Alistair Butler (St. Louis, Missouri);  Susan Farr (St. Louis, Missouri);  Clemence Girardet (Paris, France)
ABSTRACT Disclosed are methods and compositions for treating cognitive decline in subjects in need. More specifically, disclosed are methods of administrating exogenous adropin to subjects suffering from, or at risk of, cognitive decline including the aged and those suffering from traumatic brain injury. Also disclosed are subjects who would benefit from such treatment and pharmaceutical acceptable compositions comprising adropin, adropin34-76, and derivatives or variations thereof.
FILED Tuesday, November 12, 2019
APPL NO 17/614035
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/22 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/28 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370591 WISE et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) THE WISTAR INSTITUTE OF ANATOMY and BIOLOGY (Philadelphia, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Megan WISE (Plymouth Meeting, Pennsylvania);  Daniel W. KULP (Moorestown, New Jersey);  David B. WEINER (Merion, Pennsylvania)
ABSTRACT Disclosed are compositions comprising an expressible nucleic acid sequence comprising a first nucleic acid sequence comprising a leader sequence or a pharmaceutically acceptable salt thereof; and a second nucleic acid sequence comprising a sequence that encodes a trimer of a retroviral envelope or a pharmaceutically acceptable salt thereof. In some embodiments, the expressible nucleic acid sequence further comprises a nucleic acid sequence encoding at least one viral antigen or a pharmaceutically acceptable salt thereof. In some embodiments, the expressible nucleic acid sequence further comprises at least one nucleic acid sequence encoding a linker. Also disclosed are pharmaceutical compositions comprising these compositions and methods of using the disclosed compositions.
FILED Monday, April 06, 2020
APPL NO 17/601412
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/12 (20130101) Original (OR) Class
A61K 47/00 (20130101)
A61K 2039/53 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/18 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370593 Balint et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) Etubics Corporation (Seattle, Washington)
ASSIGNEE(S)
INVENTOR(S) Joseph P. Balint (Seattle, Washington);  Frank R. Jones (Seattle, Washington);  Richard B. Gayle, III (Seattle, Washington)
ABSTRACT Methods for generating immune responses using adenovirus vectors that allow multiple vaccinations with the same adenovirus vector and vaccinations in individuals with preexisting immunity to adenovirus are provided.
FILED Thursday, August 04, 2022
APPL NO 17/881131
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/191 (20130101)
A61K 38/193 (20130101)
A61K 38/204 (20130101)
A61K 38/208 (20130101)
A61K 38/217 (20130101)
A61K 38/2013 (20130101)
A61K 38/2026 (20130101)
A61K 38/2033 (20130101)
A61K 38/2046 (20130101)
A61K 38/2066 (20130101)
A61K 39/00 (20130101)
A61K 39/0011 (20130101)
A61K 39/12 (20130101) Original (OR) Class
A61K 39/21 (20130101)
A61K 39/235 (20130101)
A61K 39/001106 (20180801)
A61K 39/001182 (20180801)
A61K 2039/54 (20130101)
A61K 2039/57 (20130101)
A61K 2039/545 (20130101)
A61K 2039/575 (20130101)
A61K 2039/5256 (20130101)
A61K 2039/55555 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Peptides
C07K 14/005 (20130101)
C07K 14/71 (20130101)
C07K 14/70503 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/86 (20130101)
C12N 2710/10034 (20130101)
C12N 2710/10321 (20130101)
C12N 2710/10334 (20130101)
C12N 2710/10343 (20130101)
C12N 2710/10371 (20130101)
C12N 2710/20034 (20130101)
C12N 2740/15034 (20130101)
C12N 2740/16234 (20130101)
C12N 2800/24 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370627 KANNER et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York)
ASSIGNEE(S)
INVENTOR(S) Scott KANNER (New York, New York);  Henry M. COLECRAFT (New York, New York)
ABSTRACT The present disclosure provides, inter alia, bivalent small molecules and methods for treating or ameliorating the effects of a disease, such as long QT syndrome, or cystic fibrosis, in a subject, using the bivalent small molecules disclosed herein. Also provided are methods of identifying and preparing small molecule binders that target proteins of interest.
FILED Wednesday, July 13, 2022
APPL NO 17/864382
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/404 (20130101)
A61K 47/55 (20170801) Original (OR) Class

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/1093 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6869 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370639 Mendell et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) NATIONWIDE CHILDREN'S HOSPITAL, INC. (Columbus, Ohio)
ASSIGNEE(S)
INVENTOR(S) Jerry R. Mendell (Columbus, Ohio);  Louis Chicoine (Columbus, Ohio);  Louise Rodino-Klapac (Columbus, Ohio);  Kelly Reed Clark (Columbus, Ohio);  Thomas J. Preston (Columbus, Ohio)
ABSTRACT The present invention relates to recombinant adeno-associated virus (rAAV) delivery of an alpha-sarcoglycan gene. The invention provides rAAV products and methods of using the rAAV in the treatment of limb girdle muscular dystrophies such as LGMD2D.
FILED Tuesday, May 17, 2022
APPL NO 17/746228
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/1709 (20130101)
A61K 48/005 (20130101)
A61K 48/0058 (20130101) Original (OR) Class
A61K 48/0066 (20130101)
A61K 48/0075 (20130101)

Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor
A61M 1/3603 (20140204)
A61M 5/1408 (20130101)

Peptides
C07K 14/4707 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 7/00 (20130101)
C12N 2750/14143 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370683 Andarawis-Puri
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S) CORNELL UNIVERSITY (Ithaca, New York)
ASSIGNEE(S)
INVENTOR(S) Nelly Andarawis-Puri (Ithaca, New York)
ABSTRACT Provided are compositions and methods relating to methods and compositions to treat tendon injury.
FILED Monday, May 23, 2022
APPL NO 17/751399
CURRENT CPC
Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 27/52 (20130101)
A61L 27/54 (20130101)
A61L 27/3633 (20130101) Original (OR) Class
A61L 27/3662 (20130101)
A61L 2300/414 (20130101)
A61L 2430/10 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 19/04 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370686 Di Carlo et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S) Dino Di Carlo (Los Angeles, California);  Westbrook Weaver (San Diego, California);  Tatiana Segura (Durham, North Carolina);  Jaekyung Koh (Los Angeles, California);  Philip Scumpia (Los Angeles, California);  Donald R. Griffin (Charlottesville, Virginia)
ABSTRACT A hydrogel material for use in a human subject or other mammal includes a collection of microgel particles having one or more network cross linker components, wherein the microgel particles, when exposed to an endogenous or exogenous annealing agent, links the microgel particles together in situ to form a covalently-stabilized scaffold of microgel particles having pores formed between the microgel particles wherein the pores are substantially devoid of hydrogel.
FILED Saturday, July 30, 2022
APPL NO 17/877933
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0019 (20130101)
A61K 9/1635 (20130101)
A61K 9/1641 (20130101)
A61K 9/1652 (20130101)
A61K 39/39 (20130101)
A61K 2039/60 (20130101)

Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 27/52 (20130101) Original (OR) Class
A61L 27/54 (20130101)
A61L 27/56 (20130101)

Derivatives of Natural Macromolecular Compounds
C08H 1/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370687 Lee et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
NIH Office of the Director (NIHOD)
National Institute of Neurological Disorders and Stroke (NINDS)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) Rutgers, The State University of New Jersey (New Brunswick, New Jersey)
ASSIGNEE(S) Rutgers, The State University of New Jersey (New Brunswick, New Jersey)
INVENTOR(S) Ki-Bum Lee (Monmouth Junction, New Jersey);  Letao Yang (Piscataway, New Jersey)
ABSTRACT A three dimensional scaffold for generating cell or protein assemblies. This degradable scaffold can be applied to various types of cells. Also disclosed are methods of treating a condition by implanting the protein or cell assembly prepared according to the method described herein.
FILED Tuesday, May 24, 2022
APPL NO 17/664792
CURRENT CPC
Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 27/14 (20130101)
A61L 27/025 (20130101)
A61L 27/56 (20130101) Original (OR) Class
A61L 2400/12 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370805 Cogan et al.
FUNDED BY
Department of Veterans Affairs (DVA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) Duke University (Durham, North Carolina);  New York University (, None);  U.S. GOVENMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia);  University of Utah Research Foundation (Salt Lake City, Utah);  BLACKROCK MICROSYSTEMS, LLC dba (Salt Lake City, Utah)
ASSIGNEE(S)
INVENTOR(S) Gregory Cogan (Durham, North Carolina);  Jonathan Viventi (Durham, North Carolina);  Nandan Lad (Durham, North Carolina);  Bijan Pesaran (New York, New York);  Virginia Woods (Durham, North Carolina);  Chia-Han Chiang (Durham, North Carolina);  Charles Wang (Durham, North Carolina);  Katrina Barth (Durham, North Carolina);  Werner Doyle (New York, New York);  Patricia Dugan (New York, New York);  Orrin Devinsky (New York, New York);  Sasha Devore (New York, New York);  Daniel Friedman (New York, New York);  Amy Orsborn (New York, New York);  Florian Solzbacher (Salt Lake City, Utah);  Robert Franklin (Salt Lake City, Utah);  Sandeep Negi (Salt Lake City, Utah);  Saket Mulge (Salt Lake City, None)
ABSTRACT The present disclosure provides systems and methods related to electroencephalography (EEG) electrode arrays. In particular, the present disclosure provides systems and methods relating to the manufacture and use of high-resolution electrocorticography (ECOG) electrode arrays and stereoelectroencephalography (SEEG) electrode arrays having various combinations and arrangements of microelectrodes and macroelectrodes for recording and modulating nervous system activity.
FILED Friday, September 18, 2020
APPL NO 17/761369
CURRENT CPC
Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 1/36064 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220371009 He et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
APPLICANT(S) University of Maryland, College Park (College Park, Maryland)
ASSIGNEE(S)
INVENTOR(S) Xiaoming He (Bethesda, Maryland);  Alisa White (Greenbelt, Maryland)
ABSTRACT A system for selective microcapsule extraction includes a non-planar core-shell microfluidic device. The non-planar core-shell microfluidic device generates microcapsules defining a core-shell configuration. A subset of the microcapsules contain aggregates, tissues, or at least one cell. A camera captures images of the microcapsules. A detection module includes a processor and a memory. The memory includes instructions that when executed by the processor causes the detection module to provide the images of the microcapsules as an input to a machine learning model. The machine learning model identifies microcapsules containing aggregates, tissues, or at least one cell. A force generator generates a force to extract the microcapsules. A microcontroller selectively activates the force generator to generate the force when the detection module identifies a microcapsule containing aggregates, tissues, or at least one cell to extract the microcapsule.
FILED Wednesday, April 20, 2022
APPL NO 17/725096
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 3/50273 (20130101) Original (OR) Class
B01L 3/502715 (20130101)

Image or Video Recognition or Understanding
G06V 20/69 (20220101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220371547 SHIN et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computer and Network Systems (CNS)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan);  THE UNIVERSITY OF COLORADO (Denver, Colorado)
ASSIGNEE(S) THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan);  THE UNIVERSITY OF COLORADO (Denver, Colorado)
INVENTOR(S) Kang G. SHIN (Ann Arbor, Michigan);  Liang HE (Denver, Colorado)
ABSTRACT A driving authentication system is presented for a vehicle. The system includes: a dongle interfaced with a battery of the vehicle and an authenticator configured to receive a discharge current from the battery. The dongle operates to modulate discharge current from the battery with an input code; and the authenticator demodulate the input code from the discharge current, compares the input code to the one or more known authentication codes and, in response to the input code matching one of the one or more known authentication codes, controls power capacity of the battery.
FILED Thursday, March 24, 2022
APPL NO 17/703346
CURRENT CPC
Vehicles, Vehicle Fittings, or Vehicle Parts, Not Otherwise Provided for
B60R 25/04 (20130101)
B60R 25/23 (20130101) Original (OR) Class
B60R 25/1001 (20130101)

Starting of Combustion Engines; Starting Aids for Such Engines, Not Otherwise Provided for
F02N 11/087 (20130101)
F02N 11/0862 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220371986 Wang
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Lei Wang (San Francisco, California)
ABSTRACT Provided herein are, inter alia, methods of forming chemically reactive amino acids and methods of using same.
FILED Friday, April 03, 2020
APPL NO 17/599907
CURRENT CPC
Acyclic or Carbocyclic Compounds
C07C 227/16 (20130101) Original (OR) Class

Peptides
C07K 2/00 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 1/20 (20130101)
C12N 9/93 (20130101)
C12N 15/70 (20130101)
C12N 2800/101 (20130101)

Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture
C12P 21/02 (20130101)

Enzymes
C12Y 601/01026 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372014 Dawson et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) The Johns Hopkins University (Baltimore, Maryland);  Rapafusyn Research and Development, Inc. (Baltimore, Maryland)
ASSIGNEE(S)
INVENTOR(S) Ted M. Dawson (Baltimore, Maryland);  Valina L. Dawson (Baltimore, Maryland);  Jun Liu (Baltimore, Maryland);  Hyejin Park (Baltimore, Maryland);  Tae-In Kam (Baltimore, Maryland);  Hanjing Peng (Baltimore, Maryland);  Venkata Subbarao Ayinampudi (Baltimore, Maryland);  Sam Hong (Baltimore, Maryland);  Brett Ullman (Baltimore, Maryland);  Puneet Kumar (Baltimore, Maryland);  Magesh Sadagopan (Baltimore, Maryland)
ABSTRACT The present disclosure provides neuroprotective compounds along with their use in treating disease such as Parkinson's disease (PD). The compounds can be used as inhibitors for Parthanatos Associated AIF (apoptosis-inducing factor) Nuclease (PAAN), also known as macrophage migration inhibitor factor (MIF).
FILED Wednesday, September 30, 2020
APPL NO 17/765418
CURRENT CPC
Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/28 (20180101)

Heterocyclic Compounds
C07D 401/06 (20130101) Original (OR) Class
C07D 401/14 (20130101)
C07D 405/14 (20130101)
C07D 409/14 (20130101)
C07D 413/14 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372079 Lai et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) Jonathan R. Lai (Dobbs Ferry, New York);  Julia Frei (Brugg, Switzerland);  Olivia Vergnolle (Jackson Heights, New York);  Elisabeth Nyakatura (Jersey City, New York);  George Georgiev (Bronx, New York);  Ariel Wirchnianski (Bronx, New York)
ASSIGNEE(S)
INVENTOR(S) Jonathan R. Lai (Dobbs Ferry, New York);  Julia Frei (Brugg, Switzerland);  Olivia Vergnolle (Jackson Heights, New York);  Elisabeth Nyakatura (Jersey City, New York);  George Georgiev (Bronx, New York);  Ariel Wirchnianski (Bronx, New York)
ABSTRACT Specific resurfaced Dengue virus glycoprotein subunit E DIII variants and their uses in preventing and treating Dengue virus infection are disclosed. Provided herein are specific resurfaced Zika virus glycoprotein subunit E DIII variants and their uses in preventing and treating Zika virus infection. Multivalent vaccines comprising such resurfaced EDIII variants are also described, in addition to nanoparticle conjugated resurfaced EDIII variants.
FILED Wednesday, June 24, 2020
APPL NO 17/621513
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/12 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/14 (20180101)

Peptides
C07K 14/005 (20130101) Original (OR) Class

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 7/00 (20130101)
C12N 2770/24122 (20130101)
C12N 2770/24134 (20130101)
C12N 2770/24171 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372096 Merchant et al.
FUNDED BY
Department of Health and Human Services (HHS)
APPLICANT(S) Medicenna Therapeutics Inc. (Toronto, Canada);  The United States of America, as represented by the Secretary, Department of Health and Human Servic (Silver Spring, Maryland)
ASSIGNEE(S)
INVENTOR(S) Fahar Merchant (Vancouver, Canada);  Raj K. Puri (Potomac, Maryland);  Joshi H. Bharatkumar (Rockville, Maryland)
ABSTRACT The present invention relates to interleukin-4 receptor-binding fusion proteins. More specifically, the invention provides, in part, fusion proteins that include an interleukin-4 or interleukin-13 protein moiety joined to an anti-apoptotic Bcl-2 family member protein moiety.
FILED Friday, May 06, 2022
APPL NO 17/738620
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)
A61K 38/193 (20130101)
A61K 38/1761 (20130101)
A61K 38/2026 (20130101)

Peptides
C07K 14/4747 (20130101)
C07K 14/5406 (20130101) Original (OR) Class
C07K 2319/00 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0602 (20130101)
C12N 5/0636 (20130101)
C12N 15/63 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372101 ROYBAL et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
NIH Office of the Director (NIHOD)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Kole T. ROYBAL (Oakland, California);  Raymond LIU (Oakland, California);  Iowis ZHU (Oakland, California)
ABSTRACT The present disclosure generally relates to, among other things, a new class of receptors engineered to modulate transcription in a ligand-dependent manner. The new receptors provide a selectable degree of noise, expression level, and signal to noise ratio. The disclosure also provides compositions and methods useful for producing such receptors, nucleic acids encoding same, host cells genetically modified with the nucleic acids, as well as methods for modulating an activity of a cell and/or for the treatment of various health conditions or diseases, such as cancers.
FILED Wednesday, September 23, 2020
APPL NO 17/763110
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/17 (20130101)
A61K 38/22 (20130101)
A61K 38/177 (20130101)
A61K 38/1709 (20130101)
A61K 38/1774 (20130101)
A61K 39/3955 (20130101)
A61K 45/06 (20130101)
A61K 2039/505 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)
A61P 35/02 (20180101)

Peptides
C07K 14/47 (20130101)
C07K 14/575 (20130101)
C07K 14/705 (20130101) Original (OR) Class
C07K 14/70517 (20130101)
C07K 16/2803 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372102 Yang et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) The Regents of the University of California (Oakland, California)
INVENTOR(S) Lili Yang (Los Angeles, California);  Drake J. Smith (Los Angeles, California)
ABSTRACT Disclosed herein are invariant natural killer T (iNKT) cells engineered using hematopoietic stem and progenitor cells (HSPCs) and methods of making and using thereof.
FILED Wednesday, February 10, 2021
APPL NO 17/172925
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 48/00 (20130101)
A61K 2039/5154 (20130101)

Peptides
C07K 14/7051 (20130101) Original (OR) Class
C07K 14/70503 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0646 (20130101)
C12N 2506/11 (20130101)
C12N 2510/00 (20130101)
C12N 2740/13043 (20130101)
C12N 2830/48 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372103 Hinrichs et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland)
ASSIGNEE(S) The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland)
INVENTOR(S) Christian S. Hinrichs (Bethesda, Maryland);  Steven A. Rosenberg (Potomac, Maryland)
ABSTRACT Disclosed is a synthetic T cell receptor (TCR) having antigenic specificity for an HLA-A2-restricted epitope of human papillomavirus (HPV) 16 E7, E711-19. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells are also provided. Antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention are also provided. Also disclosed are methods of detecting the presence of a condition in a mammal and methods of treating or preventing a condition in a mammal, wherein the condition is cancer, HPV 16 infection, or HPV-positive premalignancy.
FILED Monday, August 01, 2022
APPL NO 17/816496
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)
A61K 38/1774 (20130101)

Peptides
C07K 14/7051 (20130101) Original (OR) Class
C07K 16/2809 (20130101)
C07K 2319/00 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/56983 (20130101)
G01N 33/57484 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372116 Lai et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina)
ASSIGNEE(S)
INVENTOR(S) Samuel Lai (Carrboro, North Carolina);  M. Gregory Forest (Chapel Hill, North Carolina);  Christine Henry (Chapel Hill, North Carolina);  Timothy Wessler (Durham, North Carolina);  Alexander Chen (Glenville, New York);  Jennifer Schiller (Chapel Hill, North Carolina);  Jay Newby (Carrboro, North Carolina)
ABSTRACT The presently-disclosed subject matter relates to crosslinkers, compositions, and methods for trapping a target of interest on a substrate of interest. The methods may be used to inhibit and treat pathogen infection and provide contraception. The methods may be used to trap or separate particles and other substances. The subject matter further relates to methods of identifying and preparing optimal crosslinkers and methods for manipulating targets of interest.
FILED Friday, March 18, 2022
APPL NO 17/698645
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/00 (20180101)

Peptides
C07K 16/44 (20130101)
C07K 16/087 (20130101)
C07K 16/1045 (20130101)
C07K 16/1235 (20130101) Original (OR) Class

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/557 (20130101)
G01N 33/6854 (20130101)
G01N 33/54346 (20130101)
G01N 33/56983 (20130101)
G01N 2333/16 (20130101)
G01N 2333/4725 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372164 Forman et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) City of Hope (Duarte, California)
ASSIGNEE(S)
INVENTOR(S) Stephen J. Forman (Duarte, California);  Christine E. Brown (Duarte, California);  Uma Maheswara Rao Jonnalagadda (Troy, Michigan);  Armen Mardiros (Glendale, California)
ABSTRACT Chimeric antigen receptors that include an antigen recognition domain; a spacer domain derived from a modified immunoglobulin Fc region having one or more mutations in its CH2 region resulting in impaired binding to an FcR; and an intracellular signaling domain.
FILED Monday, October 25, 2021
APPL NO 17/510099
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/39558 (20130101)
A61K 45/06 (20130101)
A61K 2039/5156 (20130101)

Peptides
C07K 14/71 (20130101)
C07K 14/7051 (20130101)
C07K 14/70517 (20130101)
C07K 14/70521 (20130101)
C07K 16/00 (20130101)
C07K 16/30 (20130101) Original (OR) Class
C07K 16/2803 (20130101)
C07K 16/2866 (20130101)
C07K 2317/524 (20130101)
C07K 2317/622 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372172 Szeto et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Drug Abuse (NIDA)
APPLICANT(S) Cornell Research Foundation, Inc. (New York, New York)
ASSIGNEE(S) Cornell Research Foundation, Inc. (New York, New York)
INVENTOR(S) Hazel H. Szeto (New York, New York);  Kesheng Zhao (Jackson Heights, New York);  Hugh Robertson (New York, New York);  Alex V. Birk (New York, New York)
ABSTRACT The invention relates to carrier complexes and methods for delivering molecules to cells. The carrier complexes comprises a molecule and an aromatic cationic peptide in accordance with the invention. In one embodiment, the method for delivering a molecule to a cell comprises contacting the cell with a carrier complex. In another embodiment, the method for delivering a molecule to a cell comprises contacting the cell with a molecule and an aromatic cationic peptide.
FILED Monday, November 08, 2021
APPL NO 17/521425
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/713 (20130101)
A61K 38/47 (20130101)
A61K 47/64 (20170801)
A61K 47/645 (20170801)

Peptides
C07K 5/08 (20130101)
C07K 5/1016 (20130101)
C07K 5/1019 (20130101)
C07K 17/00 (20130101) Original (OR) Class

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/96 (20130101)
C12N 9/2471 (20130101)
C12N 15/87 (20130101)
C12N 15/113 (20130101)
C12N 2310/3513 (20130101)
C12N 2320/32 (20130101)

Enzymes
C12Y 302/01023 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372200 GIANNESCHI et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) Northwestern University (Evanston, Illinois)
ASSIGNEE(S) Northwestern University (Evanston, Illinois)
INVENTOR(S) Nathan C. GIANNESCHI (Evanston, Illinois);  Hao SUN (Evanston, Illinois)
ABSTRACT Aspects of the invention include a method for synthesizing a peptide brush polymer, the method comprising: exposing a mixture comprising peptide-containing monomers, one or more photoinitiators, and one or more chain transfer agents to a light sufficient to induce photopolymerization, and photopolymerizing the peptide-containing monomers in the mixture; wherein: the resulting peptide brush polymer comprises at least one peptide-containing polymer block; the at least one peptide-containing polymer block is characterized by a degree of polymerization of at least 10 and a peptide graft density of 50% to 100%; and at least one peptide moiety of the at least one peptide-containing polymer block has 5 or more amino acid groups.
FILED Tuesday, September 29, 2020
APPL NO 17/764746
CURRENT CPC
Peptides
C07K 1/1077 (20130101)

Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds
C08F 2/10 (20130101)
C08F 2/50 (20130101)
C08F 299/022 (20130101) Original (OR) Class
C08F 2438/03 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372453 STAMOS et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
ASSIGNEE(S)
INVENTOR(S) Jennifer L. STAMOS (Austin, Texas);  Alfred M. LENTZSCH (Austin, Texas);  Seung Kuk PARK (Austin, Texas);  Georg MOHR (Austin, Texas);  Alan M. LAMBOWITZ (Austin, Texas)
ABSTRACT A crystal structure of a Non-LTR-retroelement reverse transcriptase and methods of using the same to identify enzymes with improved activity are provided. Mutant reverse transcriptase enzymes and methods of using the same are also provided.
FILED Tuesday, May 10, 2022
APPL NO 17/741437
CURRENT CPC
Peptides
C07K 2299/00 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/1276 (20130101) Original (OR) Class

Enzymes
C12Y 207/07049 (20130101)

Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor
C30B 29/58 (20130101)

Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology
G16B 15/00 (20190201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372467 Chatterjee et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) TRUSTEES OF BOSTON COLLEGE (Chestnut Hill, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Abhishek Chatterjee (Lexington, Massachusetts);  Rachel E. Kelemen (Newton, Massachusetts);  Delilah Jewel (Chestnut Hill, Massachusetts)
ABSTRACT The present invention involves the ability to 1) use a virus assisted directed evolution platform to significantly improve the activity of engineered nonsense-suppressor tRNAs in mammalian cells, 2) provide mutants of archaeal pyrrolysyl and E. coli leucyl tRNAs that show remarkably improved Uaa incorporation efficiency in mammalian cells, and 3) use these tRNAs to express recombinant proteins in mammalian cells incorporating Uaas at significantly improved yields.
FILED Friday, June 19, 2020
APPL NO 17/620887
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/67 (20130101)
C12N 15/86 (20130101)
C12N 15/1058 (20130101) Original (OR) Class
C12N 2750/14122 (20130101)
C12N 2750/14143 (20130101)

Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture
C12P 21/02 (20130101)

Enzymes
C12Y 601/01026 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372474 Quijano et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) Yale University (New Haven, Connecticut)
ASSIGNEE(S)
INVENTOR(S) Elias Quijano (Durham, Connecticut);  Stanley Oyaghire (New Haven, Connecticut);  W. Mark Saltzman (New Haven, Connecticut);  Peter Glazer (Guilford, Connecticut)
ABSTRACT Peptide nucleic acid (PNA) oligomers having one or more hydroxymethyl γ-substitutions, also referred to herein as “serγPNA”, are provided. The hydroxymethyl γ-substitution preserves and amplifies the helical preorganization that is valuable for DNA duplex invasion by the oligomer. serγPNA-containing triplex-forming molecules can be used in combination with a donor DNA fragment to facilitate genome modification in vitro and in vivo.
FILED Monday, June 22, 2020
APPL NO 17/620358
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/14 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/113 (20130101) Original (OR) Class
C12N 2310/15 (20130101)
C12N 2310/3181 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372476 Khvorova et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Child Health and Human Development (NICHD)
NIH Office of the Director (NIHOD)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Anastasia Khvorova (Westborough, Massachusetts);  Bruno Miguel da Cruz Godinho (Worcester, Massachusetts);  Matthew Hassler (Worcester, Massachusetts)
ABSTRACT Therapeutic oligonucleotides comprising pharmacokinetic (PK)-modifying anchors are provided. Methods for treating diseases or disorders comprising administering to a subject a therapeutic oligonucleotide comprising one or more PK-modifying anchors are provided.
FILED Wednesday, April 20, 2022
APPL NO 17/725102
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/113 (20130101) Original (OR) Class
C12N 2310/11 (20130101)
C12N 2310/14 (20130101)
C12N 2310/314 (20130101)
C12N 2310/315 (20130101)
C12N 2310/321 (20130101)
C12N 2310/322 (20130101)
C12N 2310/351 (20130101)
C12N 2310/531 (20130101)
C12N 2310/3181 (20130101)
C12N 2310/3231 (20130101)
C12N 2310/3513 (20130101)
C12N 2310/3515 (20130101)
C12N 2320/32 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372480 NGUYEN et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) The Research Foundation for The State University of New York (Amherst, New York);  The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina)
ASSIGNEE(S)
INVENTOR(S) Juliane NGUYEN (Buffalo, New York);  Scott FERGUSON (North Tonawanda, New York);  Emily BONACQUISTI (Chapel Hill, North Carolina)
ABSTRACT Provided are RNA polynucleotide sequences referred to as “EXO-Codes.” The RNA polynucleotides comprise one or more nucleotide sequences that facilitate preferential enrichment of secreted membranous vesicles that contain the EXO-Codes. Nucleotide motifs that contribute to these properties of the EXO-Codes are described. Modified eukaryotic cells comprising EXO-Codes are provided, and include lymphocytes such as T cells. EXO-Codes may comprise a cargo that provides a prophylactic or therapeutic effect. Exosome preparations comprising the EXO-codes are provided. Pharmaceutical compositions comprising EXO-Codes, expression vectors encoding them, and methods of using the pharmaceutical formulations are provided. The pharmaceutical compositions may comprise the EXO-Codes within membranous structures, such as exosomes. Cells that express or otherwise include the EXO-Codes are included, as are method for separating membranous structures that contain the EXO-codes from the cells.
FILED Friday, October 30, 2020
APPL NO 17/772505
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/111 (20130101)
C12N 15/113 (20130101) Original (OR) Class
C12N 2310/10 (20130101)
C12N 2310/11 (20130101)
C12N 2310/14 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372490 ZHANG et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Health Research, Inc. (Butfalo, New York)
ASSIGNEE(S)
INVENTOR(S) Yuesheng ZHANG (Orchard Park, New York);  Yun LI (Orchard Park, New York);  Lu YANG (Buffalo, New York)
ABSTRACT Provided are methods for prophylaxis or therapy of cancer. The methods are directed to cancers that are characterized by expression of a mutant p53. The mutant p53 may be a loss of function p53 mutant, dominant negative p53 mutant, or a gain of function p53 mutant. The method comprises delivering to cancer cells an agent that can inhibit expression of prolidase (PEPD) or disrupts the association of mutant p53 with PEPD.
FILED Friday, August 28, 2020
APPL NO 17/638518
CURRENT CPC
Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/1137 (20130101) Original (OR) Class
C12N 2310/14 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372492 Cruse et al.
FUNDED BY
Department of Health and Human Services (HHS)
APPLICANT(S) North Carolina State University (Raleigh, North Carolina);  The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland)
ASSIGNEE(S) North Carolina State University (Raleigh, North Carolina);  The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland)
INVENTOR(S) Glenn P. Cruse (Apex, North Carolina);  Dean D. Metcalfe (Bethesda, Maryland)
ABSTRACT Methods for treating diseases and conditions mediated by the high affinity IgE receptor (FcεRI). Antisense oligomers for modulating splicing of mRNA encoding the FcεRIβ protein, thereby down-regulating cell-surface expression of FcεRI, and uses of the antisense oligomers for inhibiting mast cell degranulation, cytokine release, migration, and proliferation.
FILED Monday, March 07, 2022
APPL NO 17/688618
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/7088 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 29/00 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/11 (20130101)
C12N 15/1138 (20130101) Original (OR) Class
C12N 2310/11 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372493 GUO et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio)
ASSIGNEE(S)
INVENTOR(S) Peixuan GUO (Columbus, Ohio);  Satheesh ELLIPILLI (Columbus, Ohio);  Hongzhi WANG (Columbus, Ohio);  Congcong XU (Columbus, Ohio);  Xin LI (Columbus, Ohio)
ABSTRACT Disclosed herein are compositions and methods for targeted treatment of liver cancers with Paclitaxel and miR-122. The disclosed composition comprises RNA nanostructure conjugated to a hepatocyte targeting ligand, paclitaxel, and miR-122 for use in intracellular drug delivery to liver cancer cells. The RNA nanoparticle can involve three or more self-assembled synthetic RNA oligonucleotides that form a central core domain and at least three double-stranded arms arranged around the core domain and extending away from the central core domain.
FILED Thursday, December 17, 2020
APPL NO 17/757303
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 47/549 (20170801)
A61K 47/6929 (20170801)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 5/00 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/111 (20130101)
C12N 15/1138 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372511 Tidball et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) James G. Tidball (Los Angeles, California);  Michelle Webhling-Henricks (Los Angeles, California);  Steven Welc (Los Angeles, California)
ABSTRACT Provided herein are polynucleotide constructs comprising a CD11b promoter operably linked to a nucleic acid encoding one or more therapeutic polypeptides, to vectors, cells, and/or compositions comprising the same, and to methods of their use.
FILED Friday, June 12, 2020
APPL NO 17/618292
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/28 (20130101)
A61K 38/00 (20130101)

Peptides
C07K 14/715 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/86 (20130101) Original (OR) Class
C12N 2750/14143 (20130101)
C12N 2830/008 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372517 STANKEY et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Complementary and Integrative Health (NCCIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) TERRA BIOWORKS, INC. (Middleton, Wisconsin)
ASSIGNEE(S)
INVENTOR(S) Robert Joseph STANKEY (MADISON, Wisconsin);  DAVID MEAD (MIDDLETON, Wisconsin)
ABSTRACT Disclosed herein are recombinant methods of activating expression of one or more biosynthetic gene clusters comprising more than one gene, the method comprising a recombinant DNA expression vector that possess two opposable inducible promoters that drives expression of a biosynthetic gene cluster exogenously from outside of the cluster to produce polyketides or non-ribosomal peptides in a heterologous host.
FILED Monday, July 18, 2022
APPL NO 17/813088
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/52 (20130101)
C12N 15/70 (20130101)
C12N 15/86 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372525 Severinov et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
National Institute of General Medical Sciences (NIGMS)
National Institute of Mental Health (NIMH)
APPLICANT(S) The Broad Institute, Inc. (Cambridge, Massachusetts);  Massachusetts Institute of Technology (Cambridge, Massachusetts);  President and Fellows of Harvard College (Cambridge, Massachusetts);  Rutgers, The State University of New Jersey (New Brunswick, New Jersey);  Skolkovo Institute of Science and Technology (Moscow Region, Russian Federation);  The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland)
ASSIGNEE(S)
INVENTOR(S) Konstantin Severinov (New Brunswick, New Jersey);  Feng Zhang (Cambridge, Massachusetts);  Yuri I. Wolf (Bethesda, Maryland);  Sergey Shmakov (Moscow, Russian Federation);  Ekaterina Semenova (New Brunswick, New Jersey);  Leonid Minakhin (New Brunswick, New Jersey);  Kira S. Makarova (Bethesda, Maryland);  Eugene Koonin (Bethesda, Maryland);  Silvana Konermann (Cambridge, Massachusetts);  Julia Joung (Cambridge, Massachusetts);  Jonathan S. Gootenberg (Cambridge, Massachusetts);  Omar O. Abudayyeh (Cambridge, Massachusetts);  Eric S. Lander (Cambridge, Massachusetts)
ABSTRACT The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.
FILED Friday, June 24, 2022
APPL NO 17/848563
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/22 (20130101)
C12N 15/63 (20130101)
C12N 15/85 (20130101)
C12N 15/102 (20130101)
C12N 15/111 (20130101)
C12N 15/113 (20130101)
C12N 15/907 (20130101) Original (OR) Class
C12N 15/8201 (20130101)
C12N 2310/20 (20170501)
C12N 2310/111 (20130101)
C12N 2800/22 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372544 M'KOMA
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
National Cancer Institute (NCI)
National Center for Research Resources (NCRR)
National Institute on Drug Abuse (NIDA)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
National Institute on Minority Health and Health Disparities (NIMHD)
APPLICANT(S) Meharry Medical College (Nashville, Tennessee)
ASSIGNEE(S)
INVENTOR(S) Amosy M'KOMA (Antioch, Tennessee)
ABSTRACT Methods and materials are disclosed for testing biomarkers in a subject suffering from inflammatory bowel disease (IBD) are described herein. Such detection can be useful for diagnosing and treating ulcerative colitis (UC) and Crohn's disease (CD), two forms of IBD that are otherwise difficult to distinguish. The method includes measuring the level of one or more of several biomarkers, including HD5 or MMP-7, which are expressed differentially in patents with UC and CD. A treatment may be based on the determination of whether the subject has ulcerative colitis or Crohn's disease.
FILED Monday, July 25, 2022
APPL NO 17/872674
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 45/06 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/37 (20130101) Original (OR) Class
C12Q 1/6837 (20130101)
C12Q 1/6876 (20130101)
C12Q 1/6883 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/60 (20130101)
G01N 33/68 (20130101)
G01N 33/582 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372551 Setliff et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) Vanderbilt University (Nashville, Tennessee)
ASSIGNEE(S)
INVENTOR(S) Marion Francis Setliff (Nashville, Tennessee);  Ivelin Stefanov Georgiev (Brentwood, Tennessee);  Andrea Shiakolas (Nashville, Tennessee);  Kelsey PILEWSKI (Nashville, Tennessee);  Rohit VENKAT (Nashville, Tennessee)
ABSTRACT The present disclosure relates to high-throughput systems and methods for the detection of ligand-blocking antibodies and for determining antibody potency.
FILED Thursday, July 22, 2021
APPL NO 17/795104
CURRENT CPC
Peptides
C07K 16/1063 (20130101)
C07K 2317/76 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/703 (20130101)
C12Q 1/6806 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372553 Madrid et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
National Science Foundation (NSF)
Directorate for Education and Human Resources (EHR)
Division of Human Resource Development (HRD)
APPLICANT(S) Andy Madrid (Madison, Wisconsin);  Reid Spencer Alisch (Prairie du Sac, Wisconsin);  Kirk Jeffrey Hogan (Madison, Wisconsin)
ASSIGNEE(S)
INVENTOR(S) Andy Madrid (Madison, Wisconsin);  Reid Spencer Alisch (Prairie du Sac, Wisconsin);  Kirk Jeffrey Hogan (Madison, Wisconsin)
ABSTRACT Provided herein is technology for Alzheimer's disease testing and particularly, but not exclusively, methods, compositions, and related uses for detecting the presence of Alzheimer's disease.
FILED Friday, July 15, 2022
APPL NO 17/866284
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/686 (20130101) Original (OR) Class
C12Q 2600/154 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372576 Quake et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
NIH Office of the Director (NIHOD)
APPLICANT(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)
INVENTOR(S) Stephen R. Quake (Stanford, California);  Thomas M. Snyder (Palo Alto, California);  Hannah Valantine (Stanford, California)
ABSTRACT The invention provides methods, devices, compositions and kits for diagnosing or predicting transplant status or outcome in a subject who has received a transplant.
FILED Thursday, June 09, 2022
APPL NO 17/836671
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6858 (20130101)
C12Q 1/6883 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372582 Xing
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland)
ASSIGNEE(S)
INVENTOR(S) Michael Mingzhao Xing (Clarksville, Maryland)
ABSTRACT The present invention relates to the field of cancer. More specifically, the present invention provides methods and compositions related to certain promoter mutations in cancer. In one embodiment, a method for treating a subject having thyroid cancer comprises the steps of (a) obtaining a biological sample from the subject (b) performing an assay on the sample obtained from the subject to identify a mutation at 1 295 228 C>T (C228T) and 1 295 250 C>T (C250T), corresponding to −124 C>T and −146 C>T from the translation start site in the promoter of the telomerase reverse transcriptase (TERT) gene; (c) identifying the subject as having or likely to develop aggressive thyroid cancer if the C228T and/or C250T mutation is identified; and (d) treating the subject with one or more treatment modalities appropriate for a subject having or likely to develop aggressive thyroid cancer.
FILED Friday, June 03, 2022
APPL NO 17/831814
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6886 (20130101) Original (OR) Class
C12Q 2600/106 (20130101)
C12Q 2600/112 (20130101)
C12Q 2600/156 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372585 Moon et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Complementary and Integrative Health (NCCIH)
National Science Foundation (NSF)
Directorate for Education and Human Resources (EHR)
Division of Graduate Education (DGE)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
Department of Agriculture (USDA)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) Tae Seok Moon (St. Louis, Missouri);  Hyojeong Yi (St. Louis, Missouri);  Matthew Amrofell (St. Louis, Missouri);  Chenggang Xi (St. Louis, Missouri);  Austin Rottinghaus (St. Louis, Missouri)
ASSIGNEE(S) Washington University (St. Louis, Missouri)
INVENTOR(S) Tae Seok Moon (St. Louis, Missouri);  Hyojeong Yi (St. Louis, Missouri);  Matthew Amrofell (St. Louis, Missouri);  Chenggang Xi (St. Louis, Missouri);  Austin Rottinghaus (St. Louis, Missouri)
ABSTRACT Among the various aspects of the present disclosure is the provision of molecular sensors, microbial sensors, constructs, systems, and methods for selectively detecting aromatic compounds.
FILED Wednesday, April 27, 2022
APPL NO 17/731195
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/02 (20130101)
C12Q 1/6897 (20130101) Original (OR) Class

Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms
C12R 2001/19 (20210501)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/9406 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372586 Green et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona)
ASSIGNEE(S)
INVENTOR(S) Alexander Green (Boston, Massachusetts);  Fan Hong (Mesa, Arizona);  Soma Chaudhary (Tempe, Arizona);  Anli Tang (Gilbert, Arizona);  Hao Yan (Chandler, Arizona)
ABSTRACT Ultraspecific, programmable nucleic acid sensors capable of detecting and preferentially amplifying target DNA molecules comprising a particular SNP or mutation are provided. In some cases, the ultraspecific programmable nucleic acid sensors are useful for detecting SNP-containing DNA molecules indicative of cancer such as cell-free DNA circulating in the blood or indicative of organ transplant rejection Also provided are methods for construction of such ultraspecific nucleic acid sensors and methods for preferential amplification of target DNA molecules containing a mutation of interest, as well as testing systems for early cancer screening and routine monitoring of circulating cancer DNA using liquid biological samples such as serum, plasma, or saliva.
FILED Wednesday, August 03, 2022
APPL NO 17/879871
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6858 (20130101)
C12Q 1/6897 (20130101) Original (OR) Class
C12Q 2525/301 (20130101)
C12Q 2527/101 (20130101)
C12Q 2531/101 (20130101)
C12Q 2537/1373 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220373537 XU et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts);  THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts)
ASSIGNEE(S) TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts);  THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts)
INVENTOR(S) Ke XU (Cambridge, Massachusetts);  Marc E. LENBURG (Brookline, Massachusetts);  Ehab BILLATOS (Milton, Massachusetts);  Alejandro A. DIAZ (Boston, Massachusetts)
ABSTRACT Described herein are methods relating to the diagnosis, prognosis, and treatment of airway dysfunction, e.g., bronchiectasis by detecting gene expression in a sample obtained from a subject. Exemplary samples include a bronchial brushing, nasal brushing, sputum, or peripheral blood sample.
FILED Thursday, May 19, 2022
APPL NO 17/748404
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6883 (20130101)
C12Q 2539/10 (20130101)
C12Q 2600/118 (20130101)
C12Q 2600/158 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5023 (20130101) Original (OR) Class
G01N 2800/50 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220373548 LaBaer et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona)
ASSIGNEE(S)
INVENTOR(S) Joshua LaBaer (Chandler, Arizona);  Lusheng Song (Tempe, Arizona);  Ji Qiu (Chandler, Arizona);  Yunro Chung (Chandler, Arizona)
ABSTRACT Provided herein are methods, compositions, kits, and systems for detecting Epstein Barr virus infection (EBV) in gastric cancer (GC) patients. In particular, provided herein are methods, composition, kits, and systems for diagnosing and treating EBV-positive gastric cancer (EBV+ GC) in a biological sample of an individual based on the presence and level of antibodies against particular Epstein Barr virus proteins. EBV+ GC is a distinct subtype of gastric cancer and is associated with unique molecular profiles. Also provided herein are methods for providing more personalized therapy for each of these distinct cancer subtypes and methods for determining an Epstein Barr virus-positive gastric cancer antibody signature, and kits comprising components and protocols for performing the methods of this disclosure.
FILED Friday, October 23, 2020
APPL NO 17/771595
CURRENT CPC
Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/56994 (20130101) Original (OR) Class
G01N 33/57446 (20130101)
G01N 2333/05 (20130101)
G01N 2474/10 (20210801)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220373559 Ranum et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) University of Florida Research Foundation, Incorporated (Gainesville, Florida)
ASSIGNEE(S) University of Florida Research Foundation, Incorporated (Gainesville, Florida)
INVENTOR(S) Laura Ranum (Gainesville, Florida);  Lauren A. Laboissonniere (Gainesville, Florida);  Lien Nguyen (Gainesville, Florida)
ABSTRACT Aspects of the disclosure relate to methods and compositions (e.g., kits) for detecting anti-repeat-associated non-ATG (RAN) protein antibodies in a subject (e.g., a subject that has been administered a therapeutic anti-RAN protein antibody or a vaccine against a disease or disorder associated with RAN protein expression, translation, and/or accumulation, for example amyotrophic lateral sclerosis (ALS) and/or frontotemporal dementia (FTD)). In some embodiments, methods described by the disclosure comprise detecting one or more anti-RAN protein antibodies in a biological sample obtained from a subject by an electrochemiluminescence-based immunoassay using one or more target di-amino acid repeat peptides. In some embodiments, the disclosure relates to kits comprising one or more di-amino acid repeat peptides and an electrochemiluminescence-based immunoassay plate and/or reagents.
FILED Friday, September 18, 2020
APPL NO 17/761764
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/66 (20130101)
G01N 33/6854 (20130101) Original (OR) Class
G01N 33/54366 (20130101)
G01N 2458/30 (20130101)
G01N 2800/52 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220373561 JOHNSTON
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Arizona Board of Regents on Behalf of Arizona State University (Scottsdale, Arizona)
ASSIGNEE(S)
INVENTOR(S) Stephen Albert JOHNSTON (Tempe, Arizona)
ABSTRACT A method of producing a set of high affinity peptides for detecting one or more antibodies associated with a disease or condition of interest. The method including identifying a set of informative peptides correlated to the disease or condition of interest and translating the set of informative peptides to one or more high affinity peptides for an antibody of interest, wherein the presence of the antibody of interest identifies a subject as having the disease or condition of interest. A diagnostic peptide array produced from the one or more high affinity. A method of detecting an antibody associated with a disease of condition, including: contacting a biological sample with a diagnostic peptide array; and detecting the binding of one or more antibodies to a peptide that is associated with a disease or condition of interest, thereby detecting the antibody associated with a disease of condition.
FILED Monday, August 01, 2022
APPL NO 17/816637
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/6845 (20130101)
G01N 33/6854 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220373627 Wang et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) University of Virginia Patent Foundation (Charlottesville, Virginia)
ASSIGNEE(S) University of Virginia Patent Foundation (Charlottesville, Virginia)
INVENTOR(S) Zhixing Wang (Charlottesville, Virginia);  Steven P. Allen (Charlottesville, Virginia);  Xue Feng (Zion Crossroads, Virginia);  John P. Mugler, III (Charlottesville, Virginia);  Craig H. Meyer (Charlottesville, Virginia)
ABSTRACT Methods, computing devices, and magnetic resonance imaging systems that improve image quality in turbo spiral echo (TSE) imaging are disclosed. With this technology, a TSE pulse sequence is generated that includes a series of radio frequency (RF) refocusing pulses to produce a corresponding series of nuclear magnetic resonance (NMR) spin echo signals. A gradient waveform including a plurality of segments is generated. The plurality of segments collectively comprise a spiral ring retraced in-out trajectory. During an interval adjacent to each of the series of RF refocusing pulses, a first gradient pulse is generated according to the gradient waveform. The first gradient pulses encode the NMR spin echo signals. An image is then constructed from digitized samples of the NMR spin echo signals obtained based at least in part on the encoding.
FILED Thursday, April 28, 2022
APPL NO 17/732181
CURRENT CPC
Measuring Electric Variables; Measuring Magnetic Variables
G01R 33/482 (20130101) Original (OR) Class
G01R 33/543 (20130101)
G01R 33/5608 (20130101)
G01R 33/5617 (20130101)
G01R 33/56509 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220373630 Dou et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) University of Virginia Patent Foundation (Charlottesville, Virginia)
ASSIGNEE(S)
INVENTOR(S) Quan Dou (Charlottesville, Virginia);  Zhixing Wang (Charlottesville, Virginia);  Xue Feng (Zion Crossroads, Virginia);  John P. Mugler, III (Charlottesville, Virginia);  Craig H. Meyer (Charlottesville, Virginia)
ABSTRACT Training a neural network to correct motion-induced artifacts in magnetic resonance images includes acquiring motion-free magnetic resonance image (MRI) data of a target object and applying a spatial transformation matrix to the motion-free MRI data. Multiple frames of MRI data are produced having respective motion states. A Non-uniform Fast Fourier Transform (NUFFT) can be applied to generate respective k-space data sets corresponding to each of the multiple frames of MRI; the respective k-space data sets can be combined to produce a motion-corrupted k-space data set and an adjoint NUFFT can be applied to the motion-corrupted k-space data set. Updated frames of motion-corrupted MRI data can be formed. Using the updated frames of motion corrupted MRI data, a neural network can be trained that generates output frames of motion free MRI data; and the neural network can be saved.
FILED Friday, April 29, 2022
APPL NO 17/733967
CURRENT CPC
Measuring Electric Variables; Measuring Magnetic Variables
G01R 33/5608 (20130101) Original (OR) Class
G01R 33/5611 (20130101)

Image Data Processing or Generation, in General
G06T 2207/10088 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220375082 Chatterjee et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) THE UNIVERSITY OF CHICAGO (Chicago, Illinois)
ASSIGNEE(S)
INVENTOR(S) Aritrick Chatterjee (Chicago, Illinois);  Gregory S. Karczmar (Crete, Illinois);  Aytekin Oto (Chicago, Illinois);  Xiaobing Fan (Darien, Illinois)
ABSTRACT A diagnostic system to analyze imaging data includes a memory configured to store hybrid imaging data of a tissue sample. The system also includes a processor operatively coupled to the memory and configured to generate a four quadrant plot based on the hybrid imaging data. Each point in the four quadrant plot corresponds to an image voxel of the tissue sample. The processor is also configured to determine one or more angle values and one or more distance values for image voxels in the four quadrant plot. The processor is further configured to identify one or more characteristics of the tissue sample based at least in part on the one or more angle values and the one or more distance values. The processor is further configured to perform a matrix analysis of the data, which can be used to identify the one or more characteristics of the tissue sample.
FILED Wednesday, November 11, 2020
APPL NO 17/771957
CURRENT CPC
Measuring Electric Variables; Measuring Magnetic Variables
G01R 33/5602 (20130101)
G01R 33/56341 (20130101)

Image Data Processing or Generation, in General
G06T 7/0012 (20130101) Original (OR) Class
G06T 2207/10088 (20130101)
G06T 2207/30096 (20130101)

Image or Video Recognition or Understanding
G06V 10/76 (20220101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220375141 Sandino et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)
INVENTOR(S) Christopher Michael Sandino (Menlo Park, California);  Shreyas S. Vasanawala (Stanford, California);  Frank Ong (Palo Alto, California)
ABSTRACT A method for MR imaging includes acquiring with an MR imaging apparatus undersampled k-space imaging data having one or more temporal dimensions and two or more spatial dimensions; transforming the undersampled k-space imaging data to image space data using zero-filled or sliding window reconstruction and sensitivity maps; decomposing the image space data into a compressed representation comprising a product of spatial and temporal parts, where the spatial part comprises spatial basis functions and the temporal part comprises temporal basis functions; processing the spatial basis functions and temporal basis functions to produce reconstructed spatial basis functions and reconstructed temporal basis functions, wherein the processing iteratively applies conjugate gradient and convolutional neural network updates using 2D or 3D spatial and 1D temporal networks; and decompressing the reconstructed spatial basis functions and reconstructed temporal basis functions to produce a reconstructed MRI image having one or more temporal dimensions and two or more spatial dimensions.
FILED Thursday, May 13, 2021
APPL NO 17/319316
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/055 (20130101)
A61B 5/7264 (20130101)

Image Data Processing or Generation, in General
G06T 7/11 (20170101)
G06T 11/006 (20130101) Original (OR) Class
G06T 2207/10088 (20130101)
G06T 2207/20021 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220375142 Xie et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) Huidong Xie (Troy, New York);  Ge Wang (Loudonville, New York);  Hongming Shan (Troy, New York);  Wenxiang Cong (Albany, New York)
ASSIGNEE(S) RENSSELAER POLYTECHNIC INSTITUTE (TROY, New York)
INVENTOR(S) Huidong Xie (Troy, New York);  Ge Wang (Loudonville, New York);  Hongming Shan (Troy, New York);  Wenxiang Cong (Albany, New York)
ABSTRACT A system for few-view computed tomography (CT) image reconstruction is described. The system includes a preprocessing module, a first generator network, and a discriminator network. The preprocessing module is configured to apply a ramp filter to an input sinogram to yield a filtered sinogram. The first generator network is configured to receive the filtered sinogram, to learn a filtered back-projection operation and to provide a first reconstructed image as output. The first reconstructed image corresponds to the input sinogram. The discriminator network is configured to determine whether a received image corresponds to the first reconstructed image or a corresponding ground truth image. The generator network and the discriminator network correspond to a Wasserstein generative adversarial network (WGAN). The WGAN is optimized using an objective function based, at least in part, on a Wasserstein distance and based, at least in part, on a gradient penalty.
FILED Monday, September 14, 2020
APPL NO 17/642725
CURRENT CPC
Image Data Processing or Generation, in General
G06T 11/005 (20130101)
G06T 11/006 (20130101) Original (OR) Class
G06T 2211/421 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220375540 Chabon et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
INVENTOR(S) Jacob J. Chabon (Arvad, Colorado);  David M. Kurtz (San Carlos, California);  Maximilian Diehn (San Carlos, California);  Arash Ash Alizadeh (San Mateo, California)
ABSTRACT Processes and materials to detect cancer, transplant rejection, or fetal genetic abnormalities from a biopsy are described. In some cases, nucleic acid molecules, such as cell-free nucleic acids, can be sequenced, and the sequencing result can be utilized to detect sequences indicative of a neoplasm, transplant rejection, or fetal genetic abnormality. Detection of somatic variants occurring in phase and/or insertions and deletions (indels) can indicate the presence of cancer, transplant rejection, or fetal genetic abnormalities in a diagnostic scan, and a clinical intervention can be performed.
FILED Wednesday, April 27, 2022
APPL NO 17/661034
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6869 (20130101)
C12Q 1/6886 (20130101)
C12Q 2600/156 (20130101)

Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology
G16B 20/20 (20190201) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220375542 Grant
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona)
ASSIGNEE(S)
INVENTOR(S) Adam David Grant (Tucson, Arizona)
ABSTRACT Systems and methods are described for genetic analysis. In certain embodiments, the system reads a plurality of input parameters, where the input parameters include a file-path to a mutation input file and storing the mutation input file. The mutation input file is comprised of a mutated genetic sequence, and the sorting mutations in the mutation input file are based on starting position. The computer then receives data identifying chromosome location, start position, reference allele and mutated allele for each mutation within the mutation input file and loads a standardized reference genome. In certain embodiments, the GTF file identifies the location of mutated genes in the input standardized reference genome. The system then compares the mutation input file to the standardized reference genome and generates a mutation index file. The mutation index file identifies mutated nucleotides in the customized reference genome and can be used to quantify allelic expression to diagnose a genetic condition like cancer and improve therapeutic options for cancer patients.
FILED Wednesday, May 18, 2022
APPL NO 17/747796
CURRENT CPC
Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology
G16B 20/50 (20190201) Original (OR) Class
G16B 30/00 (20190201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220375545 Grant
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Arizona Board of Arizona, Tech Transfer Arizona (Tucson, Arizona)
ASSIGNEE(S)
INVENTOR(S) Adam David Grant (Tucson, Arizona)
ABSTRACT Systems and methods are described for genetic analysis. In certain embodiments, the system reads a plurality of input parameters, where the input parameters comprise a path to a gene fusion input file and stores the gene fusion input file. The gene fusion input file is comprised of break points of genetic sequences for one or more gene fusion events. The computer then receives data identifying chromosome location, start position, end position, and strand for each gene in the gene fusion input file and loads a standardized reference genome. The computer then compares the gene fusion input file to the standardized reference genome and generates a gene fusion index file. The gene fusion index file identifies gene fusion events in the customized reference genome and can be used to quantify the number or next generation sequencing reads aligned to the wild type allele and fused allele. Allelic expression of tumor fusions can be used to diagnose a genetic condition and enhance therapeutic options for cancer patients.
FILED Wednesday, May 18, 2022
APPL NO 17/747817
CURRENT CPC
Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology
G16B 20/20 (20190201)
G16B 30/10 (20190201) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220375609 Guo et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) NemaMetrix, Inc (Eugene, Oregon)
ASSIGNEE(S) NemaMetrix, Inc. (Eugene, Oregon)
INVENTOR(S) Lan Guo (Eugene, Oregon);  Stephen Turner (Eugene, Oregon);  Trisha Brock (Eugene, Oregon);  Chris HOPKINS (Corvallis, Oregon)
ABSTRACT Disclosed herein are classifier models, computer implemented systems, machine learning systems and methods thereof for classifying clinical variants of unknown or uncertain significance into a pathogenicity category using measured phenotype features extracted from phenotype assays of transgenic organism expressing the human clinical variant. Embodiments of the present invention relate generally to methods for generating classifier models using machine learning and use of those classifier models to predict the pathogenicity of a clinical variant for a specific human disease (e.g. genetic disease), assigning a patient clinical variant to a pathogenicity category (e.g. pathogenic or benign) for the specific human disease to determine whether that patient should be followed up with additional, more invasive diagnostic testing, or treatment.
FILED Thursday, October 15, 2020
APPL NO 17/769727
CURRENT CPC
Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology
G16B 20/40 (20190201)
G16B 40/20 (20190201)

Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 50/20 (20180101) Original (OR) Class
G16H 70/60 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220377560 ZENG
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computer and Network Systems (CNS)
APPLICANT(S) UNIVERSITY OF SOUTH CAROLINA (Columbia, South Carolina)
ASSIGNEE(S)
INVENTOR(S) QIANG ZENG (WEST COLUMBIA, South Carolina)
ABSTRACT Secure pairing is key to trustworthy deployment and application of Internet of Things (IoT) devices. However, IoT devices lack conventional user interfaces, such as keyboards and displays, which make many traditional pairing approaches inapplicable. Proximity-based pairing approaches are very usable, but can be exploited by co-located malicious devices. Approaches based on a user's physical operations on IoT devices are more secure, but typically require inertial sensors, while many devices do not satisfy this requirement. A secure and usable pairing approach that can be applied to heterogeneous IoT devices still does not exist. We develop a technique, Universal Operation Sensing, which allows an IoT device to sense the user's physical operations on it without requiring inertial sensors. With this technique, a user holding a smartphone or wearing a wristband can finish pairing in seconds through some very simple operations, e.g., pressing a button or twisting a knob. Moreover, we reveal an inaccuracy issue in original fuzzy commitment and propose faithful fuzzy commitment to resolve it. We design a pairing protocol using faithful fuzzy commitment, and build a prototype system named Touch-to-Pair (T2Pair, for short). The comprehensive evaluation shows that it is secure and usable.
FILED Thursday, March 10, 2022
APPL NO 17/691697
CURRENT CPC
Wireless Communication Networks
H04W 12/06 (20130101)
H04W 12/50 (20210101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Defense (DOD) 

US 20220370553 RONAI et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Sanford Burnham Prebys Medical Discovery Institute (La Jolla, California)
ASSIGNEE(S)
INVENTOR(S) Ze'ev A. RONAI (Fallbrook, California);  Scott PETERSON (Escondido, California);  Yan LI (San Diego, California)
ABSTRACT Described herein are methods and compositions for treating, reducing, or ameliorating cancer in a subject, comprising administering compositions comprising mucin and/or inulin. In some aspects, described herein is a method of enhancing anti-cancer immunity comprising: (a) administering to a subject a composition comprising mucin, wherein the subject has been identified as having a gut microbiome comprising one more microbial taxa that are members of a Clostridium cluster XIVa or an Actinobacteria phylum; and (b) altering the gut microbiome in the subject, wherein administration of the composition causes an enhanced anti-cancer immunity in the subject.
FILED Thursday, July 30, 2020
APPL NO 17/627558
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/733 (20130101)
A61K 38/1735 (20130101) Original (OR) Class
A61K 45/06 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370780 Donaldson et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Army Medical Research Acquisition Activity (USAMRAA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
APPLICANT(S) Critical Innovations, LLC (Lawndale, California)
ASSIGNEE(S)
INVENTOR(S) Ross I. Donaldson (Lawndale, California);  Oliver Buchanan (Lawndale, California);  Tim Fisher (Lawndale, California);  Jon Armstrong (Lawndale, California);  John Cambridge (Lawndale, California)
ABSTRACT An improved method and device are provided for forming and/or maintaining a percutaneous access pathway. The device generally comprises an access pathway and attachment device. The provided assembly substantially reduces the possibility of iatrogenic infection while accessing and/or re-accessing a body space.
FILED Thursday, August 04, 2022
APPL NO 17/881298
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 17/34 (20130101)
A61B 17/3415 (20130101)
A61B 17/3423 (20130101)
A61B 17/3498 (20130101)
A61B 90/40 (20160201)
A61B 2017/00809 (20130101)
A61B 2017/3492 (20130101)

Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor
A61M 39/0247 (20130101) Original (OR) Class
A61M 2210/101 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370804 Welle et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (Denver, Colorado)
ASSIGNEE(S)
INVENTOR(S) Cristin Welle (Denver, Colorado);  Ethan Hughes (Denver, Colorado);  Rongchen Huang (Fort Collins, Colorado)
ABSTRACT Embodiments of the instant invention relate to applying motor learning to promote remyelination following demyelination in a subject having a condition or disease. In certain embodiments, applying motor learning alone or in combination with vagus nerve stimulation (VNS) induces the production of new and preserves surviving oligodendrocytes. In accordance with certain embodiments of the disclosure, motor learning, when properly timed, enhances oligodendrogenesis after injury and recruits mature oligodendrocytes to participate in remyelination through the generation of new myelin sheaths. In other aspects of the disclosure, VNS paired with motor learning enhances remyelination following demyelination.
FILED Friday, January 21, 2022
APPL NO 17/581307
CURRENT CPC
Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals
A01K 29/005 (20130101)

Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 1/3606 (20130101)
A61N 1/36025 (20130101)
A61N 1/36034 (20170801)
A61N 1/36053 (20130101) Original (OR) Class
A61N 1/36157 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370978 Long et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
APPLICANT(S) The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
ASSIGNEE(S) The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
INVENTOR(S) Jeffrey W. Long (Alexandria, Virginia);  Christopher N. Chervin (Washington, District of Columbia);  Robert B. Balow (Mount Ranier, Maryland);  Jeffrey C. Owrutsky (Silver Spring, Maryland);  Debra R. Rolison (Arlington, Virginia);  Kenan O. Fears (Alexandria, Virginia)
ABSTRACT Disclosed is a method of decontamination by exposing a zirconium oxy(hydroxide) aerogel to a liquid, vapor, or gaseous sample suspected of containing a phosphonate compound. The aerogel may be doped with Fe3+ ions, Ce3+ ions, or SO42− ions. The aerogel may be made by: providing a solution of ZrCl4; FeCl3, CeCl3, or Zr(SO4)2; and a solvent; adding a cyclic ether to the solution to form a gel; infiltrating the gel with liquid carbon dioxide; applying a temperature and pressure to form supercritical fluid carbon dioxide; and removing the carbon dioxide for form an aerogel.
FILED Thursday, August 04, 2022
APPL NO 17/817477
CURRENT CPC
Chemical Means for Extinguishing Fires or for Combating or Protecting Against Harmful Chemical Agents; Chemical Materials for Use in Breathing Apparatus
A62D 3/33 (20130101)

Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 20/06 (20130101) Original (OR) Class
B01J 20/0207 (20130101)
B01J 20/0229 (20130101)
B01J 20/0281 (20130101)
B01J 20/28047 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370991 Emdadi et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
APPLICANT(S) U.S. Army DEVCOM Army Research Laboratory (Adelphi, Maryland)
ASSIGNEE(S)
INVENTOR(S) Laleh Emdadi (Centreville, Virginia);  Dat T. Tran (Clarksville, Maryland);  Sampath Gunukula (Beltsville, Maryland)
ABSTRACT Incorporating a bimetal to a lamellar MFI zeolite structure includes providing a bimetallic-incorporated lamellar zeolite catalyst including a sodium source, aluminum source, silicon source, surfactant, sulfuric acid, deionized water, metal source, and molecular template; dissolving the sodium source in the deionized water creating a basic solution; adding the sulfuric acid, aluminum source, molecular template, and silicon source to the basic solution creating a mixture and adding the metal source to the mixture; dissolving the surfactant in the deionized water creating a surfactant solution; combining the surfactant solution and basic solution; heating the combined surfactant solution and basic solution in a rotating autoclave creating a metal-containing zeolite including the surfactant and molecular template in a structure of the metal-containing zeolite; removing a synthesized zeolite from the autoclave; drying the synthesized zeolite and creating a dry zeolite powder; calcining the dry zeolite powder creating a bimetal-containing lamellar MFI zeolite for chemical activation.
FILED Tuesday, May 18, 2021
APPL NO 17/323448
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 29/76 (20130101)
B01J 29/78 (20130101) Original (OR) Class
B01J 35/026 (20130101)
B01J 35/1057 (20130101)
B01J 35/1061 (20130101)
B01J 37/04 (20130101)
B01J 37/06 (20130101)
B01J 37/08 (20130101)
B01J 37/009 (20130101)
B01J 37/10 (20130101)
B01J 37/0018 (20130101)
B01J 37/30 (20130101)
B01J 2229/26 (20130101)
B01J 2229/183 (20130101)
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US 20220371006 Yager et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
APPLICANT(S) University of Washington (Seattle, Washington)
ASSIGNEE(S) University of Washington (Seattle, Washington)
INVENTOR(S) Paul Yager (Seattle, Washington);  Steven Bennett (Seattle, Washington);  Sujatha Kumar (Seattle, Washington);  Kamal Girish Shah (Seattle, Washington);  Erin K. Heiniger (Seattle, Washington)
ABSTRACT An apparatus, system, and method for filtering and assaying a fluid sample are described. In an embodiment, the apparatus includes a filtration unit comprising: a filter bracket shaped to removably couple with a fluid sample cup and a vacuum container; and a filter housing cooperatively couplable to the filter bracket and comprising a filter configured to filter fluid passing through the filter bracket; and an assay device shaped to cooperatively couple with the filter housing and comprising a porous matrix positioned to be in fluidic communication with the filter when the filter housing is cooperatively coupled with the assay device.
FILED Thursday, October 01, 2020
APPL NO 17/761138
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 3/5023 (20130101) Original (OR) Class
B01L 3/5635 (20130101)
B01L 2300/042 (20130101)
B01L 2300/0681 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 1/14 (20130101)
G01N 2001/4088 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220371719 Henry et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
APPLICANT(S) U.S. Army DEVCOM Army Research Laboratory (Adelphi, Maryland)
ASSIGNEE(S)
INVENTOR(S) Todd C. Henry (Aberdeen, Maryland);  John T. Hrynuk (Joppa, Maryland);  Christopher M. Kroninger (Wallingford, Pennsylvania);  Michael R. Dorothy (Aberdeen, Maryland);  Robert A. Haynes (Yorktown, Virginia)
ABSTRACT A yaw alleviation device for an aircraft containing rotatable wing roots attached to wings. The device includes a spring configured to operatively connect to a wing; and a buckling member to operatively connect to the wing. The spring is configured to extend from an original unstrained position upon the buckling member undergoing buckling from an original unbuckled position to cause rotation of one or both wings in rotationally opposite directions. The buckling member may be positioned parallel and at an offset distance to the spring.
FILED Friday, May 21, 2021
APPL NO 17/326911
CURRENT CPC
Aeroplanes; Helicopters
B64C 3/40 (20130101) Original (OR) Class

Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft
B64D 25/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220371725 Rubin
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Naval Information Warfare Center (NIWC)
Naval Information Warfare Center Pacific (NIWCPACIFIC)
APPLICANT(S) United States of America, as represented by the Secretary of the Navy (San Diego, California)
ASSIGNEE(S)
INVENTOR(S) Stuart H. Rubin (San Diego, California)
ABSTRACT A vehicle includes a surface for contacting a fluid medium through which the vehicle is propelled. The vehicle also includes an array of transducers and a controller. The transducers in the array are arranged across the vehicle's surface for generating pressure waves in the fluid medium. Each transducer in the array is arranged to vibrate for generating a respective pressure wave, which propagates away from the surface in the fluid medium. The controller vibrates the transducers in the array so that the pressure waves control the drag of the vehicle from the fluid medium.
FILED Tuesday, August 02, 2022
APPL NO 17/879128
CURRENT CPC
Ships or Other Waterborne Vessels; Equipment for Shipping
B63B 1/34 (20130101)

Aeroplanes; Helicopters
B64C 23/005 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220371750 Garber et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
APPLICANT(S) Busek Co. Inc. (Natick, Massachusetts)
ASSIGNEE(S) Busek Co. Inc. (Natick, Massachusetts)
INVENTOR(S) Darren D. Garber (Rancho Palos Verdes, California);  Vlad Hruby (Newton, Massachusetts);  Andrew DeNucci (South Boston, Massachusetts);  Matthew Averill (Charlestown, Massachusetts);  Anthony Naccarato (Southborough, Massachusetts)
ABSTRACT An apparatus includes a primary device, a secondary device, and an umbilical system. The umbilical system comprises an umbilical linking the primary device and the secondary device, and a control system configured alter a directionality of the umbilical during deployment of the secondary device away from the primary device by at least controlling a configuration of a shape memory material comprising the umbilical.
FILED Thursday, May 19, 2022
APPL NO 17/748147
CURRENT CPC
Cosmonautics; Vehicles or Equipment Therefor
B64G 1/222 (20130101) Original (OR) Class
B64G 1/646 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220371909 Long et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
APPLICANT(S) The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
ASSIGNEE(S) The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
INVENTOR(S) Jeffrey W. Long (Alexandria, Virginia);  Christopher N. Chervin (Washington, District of Columbia);  Robert B. Balow (Mount Ranier, Maryland);  Jeffrey C. Owrutsky (Silver Spring, Maryland);  Debra R. Rolison (Arlington, Virginia);  Kenan O. Fears (Alexandria, Virginia)
ABSTRACT Disclosed is a method of decontamination by exposing a zirconium oxy(hydroxide) aerogel to a liquid, vapor, or gaseous sample suspected of containing a phosphonate compound. The aerogel may be doped with Fe3+ ions, Ce3+ ions, or SO42− ions. The aerogel may be made by: providing a solution of ZrCl4; FeCl3, CeCl3, or Zr(SO4)2; and a solvent; adding a cyclic ether to the solution to form a gel; infiltrating the gel with liquid carbon dioxide; applying a temperature and pressure to form supercritical fluid carbon dioxide; and removing the carbon dioxide for form an aerogel.
FILED Thursday, August 04, 2022
APPL NO 17/817485
CURRENT CPC
Compounds Containing Metals Not Covered by Subclasses C01D or C01F
C01G 25/02 (20130101) Original (OR) Class
C01G 25/003 (20130101)

Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds
C01P 2006/80 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220371946 SHEIK-BAHAE et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
APPLICANT(S) UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico)
ASSIGNEE(S)
INVENTOR(S) Mansoor SHEIK-BAHAE (Albuquerque, New Mexico);  Arash MAFI (Albuquerque, New Mexico);  Mostafa PEYSOKHAN (Albuquerque, New Mexico);  Esmaeil MOBINI SOUCHELMAEI (Albuquerque, New Mexico);  Saeid ROSTAMI (Albuquerque, New Mexico)
ABSTRACT A system, device, and method for laser cooling rare earth doped silica glass using anti-Stokes fluorescence is disclosed. The system includes a rare earth doped and codoped with one or more codopants silica glass; a laser that provides radiation to a first surface and through a body of the rare earth doped silica glass, wherein the laser is tuned from a first wavelength to a second wavelength; and a thermally sensitive device that captures images of the rare earth doped silica glass as the laser is tuned and determines a third wavelength between the first wavelength and the second wavelength where the rare earth doped silica glass is maximumly or near maximumly cooled.
FILED Tuesday, October 20, 2020
APPL NO 17/770678
CURRENT CPC
Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials
C03C 13/045 (20130101) Original (OR) Class
C03C 2201/36 (20130101)

Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical
H01S 3/176 (20130101)
H01S 3/0408 (20130101)
H01S 3/1618 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220371953 Srubar, III et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) The Regents of the University of Colorado, a body corporate (Denver, Colorado)
ASSIGNEE(S) The Regents of the University of Colorado, a body corporate (Denver, Colorado)
INVENTOR(S) Wilfred V. Srubar, III (Boulder, Colorado);  Sarah Lynn Williams (Boulder, Colorado);  Jeffrey Cameron (Erie, Colorado);  Mija Hubler (Boulder, Colorado);  Sherri Cook (Boulder, Colorado);  Aparna Nagarajan (Denver, Colorado);  Chelsea Heveran (Denver, Colorado)
ABSTRACT Methods of forming cement pastes, methods of forming concrete, and methods of forming other compositions using mineral particles formed from the one or more of biomineralizing microorganisms and biomineralizing microorganisms. Desired features, such as size and morphology, can be controlled by controlling growth parameters of the biomineralizing microorganisms and biomineralizing microorganisms.
FILED Friday, October 30, 2020
APPL NO 17/773448
CURRENT CPC
Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone
C04B 14/06 (20130101)
C04B 14/08 (20130101) Original (OR) Class
C04B 14/28 (20130101)
C04B 28/04 (20130101)
C04B 2103/0001 (20130101)

Treatment of Inorganic Materials, Other Than Fibrous Fillers, to Enhance Their Pigmenting or Filling Properties; Preparation of Carbon Black;
C09C 1/021 (20130101)
C09C 1/3018 (20130101)
C09C 1/3027 (20130101)
C09C 3/006 (20130101)
C09C 3/041 (20130101)
C09C 3/043 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 1/12 (20130101)
C12N 1/20 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372039 Schiltz et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Development Command (USAMRDC)
U.S. Army Medical Research and Materiel Command (USAMRMC)
APPLICANT(S) Northwestern University (Evanston, Illinois)
ASSIGNEE(S)
INVENTOR(S) Gary E. Schiltz (Naperville, Illinois);  Jindan Yu (Evanston, Illinois)
ABSTRACT Disclosed are compounds that bind to embryonic ectoderm development (EED) protein and proteolysis-targeting chimeric (PROTAC) derivatives thereof that induce degradation of EED. The disclosed compounds may be characterized as substituted [1,2,4]triazolo[4,3-c]pyrimidin-5-amine compounds. The disclosed PROTAC derivatives thereof typically include a first targeting moiety that binds to EED (MEED) which may be derived from the disclosed [1,2,4]triazolo [4,3-c]pyrimidin-5-amine compounds that bind to EED. The first targeting moiety typically is linked via a bond or a linker (L) to a second targeting moiety that binds to an E3 ubiquitin ligase (ME3). As such, the disclosed PROTACS may be described as having a formula MEED-L-ME3 or ME3-L-MEED.
FILED Friday, April 29, 2022
APPL NO 17/733752
CURRENT CPC
Heterocyclic Compounds
C07D 487/04 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372062 Mirkin et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) NORTHWESTERN UNIVERSITY (Evanston, Illinois)
ASSIGNEE(S)
INVENTOR(S) Chad A. Mirkin (Wilmette, Illinois);  Oliver G. Hayes (Evanston, Illinois);  Benjamin Edward Partridge (Chicago, Illinois)
ABSTRACT Provided herein are hierarchical protein structures comprising two or more proteins extending in one or more dimensions, the hierarchical protein structure comprising: a first protein comprising: (i) a patch A comprising one or more polynucleotides conjugated to the surface of the first protein; and (ii) a patch B comprising one or more polynucleotides conjugated to the surface of the first protein; and a second protein comprising: (i) a patch A′ comprising one or more polynucleotides conjugated to the surface of the second protein; and (ii) a patch B′ comprising one or more polynucleotides conjugated to the surface of the second protein; wherein the one or more polynucleotides of the patch A hybridizes to the one or more polynucleotides of the patch A′, and/or the one or more polynucleotides of the patch B hybridizes to the one or more polynucleotides of the patch B′ to form the hierarchical protein structure. Also provided are methods of making the hierarchical protein structures.
FILED Tuesday, May 24, 2022
APPL NO 17/752407
CURRENT CPC
Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids
C07H 21/00 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372077 Pfeilsticker et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
APPLICANT(S) California Institute of Technology (Pasadena, California)
ASSIGNEE(S)
INVENTOR(S) Jessica A. Pfeilsticker (Pasadena, California);  Aiko Umeda (Pasadena, California);  James R Heath (Pasadena, California)
ABSTRACT The present application provides stable peptide-based antibody capture agents and methods of use as detection and diagnosis agents. The application further provides methods of manufacturing antibody capture agents using iterative on-bead in situ click chemistry.
FILED Monday, June 20, 2022
APPL NO 17/844509
CURRENT CPC
Peptides
C07K 7/08 (20130101)
C07K 9/00 (20130101) Original (OR) Class

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/56988 (20130101)
G01N 2333/162 (20130101)
G01N 2469/20 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372200 GIANNESCHI et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) Northwestern University (Evanston, Illinois)
ASSIGNEE(S) Northwestern University (Evanston, Illinois)
INVENTOR(S) Nathan C. GIANNESCHI (Evanston, Illinois);  Hao SUN (Evanston, Illinois)
ABSTRACT Aspects of the invention include a method for synthesizing a peptide brush polymer, the method comprising: exposing a mixture comprising peptide-containing monomers, one or more photoinitiators, and one or more chain transfer agents to a light sufficient to induce photopolymerization, and photopolymerizing the peptide-containing monomers in the mixture; wherein: the resulting peptide brush polymer comprises at least one peptide-containing polymer block; the at least one peptide-containing polymer block is characterized by a degree of polymerization of at least 10 and a peptide graft density of 50% to 100%; and at least one peptide moiety of the at least one peptide-containing polymer block has 5 or more amino acid groups.
FILED Tuesday, September 29, 2020
APPL NO 17/764746
CURRENT CPC
Peptides
C07K 1/1077 (20130101)

Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds
C08F 2/10 (20130101)
C08F 2/50 (20130101)
C08F 299/022 (20130101) Original (OR) Class
C08F 2438/03 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372207 Kriley et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Tank Automotive Research, Development and Engineering Center (TARDEC)
APPLICANT(S) PPG Industries Ohio, Inc. (Cleveland, Ohio)
ASSIGNEE(S) PPG Industries Ohio, Inc. (Cleveland, Ohio)
INVENTOR(S) Joseph P. Kriley (Valencia, Pennsylvania);  Marvin M. Pollum, Jr. (Pittsburgh, Pennsylvania);  Masayuki Nakajima (Wexford, Pennsylvania);  David J. Fortman (Pittsburgh, Pennsylvania)
ABSTRACT The present invention is directed to a curable composition including: an isocyanate-functional prepolymer; an epoxy-containing component present in an amount of at least 10 percent by weight of the composition; and a latent curing agent having an ability to react with at least one of the isocyanate-functional prepolymer and the epoxy-containing component upon exposure to an external energy source. The present invention is also directed to methods of making the compositions, methods of coating a substrate, methods of adhering substrates and coated substrates.
FILED Wednesday, July 22, 2020
APPL NO 17/753976
CURRENT CPC
Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form
B32B 5/022 (20130101)
B32B 5/024 (20130101)
B32B 5/26 (20130101)
B32B 7/12 (20130101)
B32B 15/00 (20130101)
B32B 37/1207 (20130101)

Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds
C08G 18/10 (20130101)
C08G 18/58 (20130101) Original (OR) Class
C08G 18/755 (20130101)
C08G 18/4854 (20130101)
C08G 59/188 (20130101)
C08G 59/4021 (20130101)

Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor
C09D 163/00 (20130101)
C09D 175/04 (20130101)

Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives
C09J 163/00 (20130101)
C09J 175/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372272 ZHAO et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S) OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio);  GEORGIA TECH RESEARCH CORPORATION (Atlanta, Georgia)
ASSIGNEE(S)
INVENTOR(S) Ruike ZHAO (Columbus, Ohio);  Xiao KUANG (Atlanta, Georgia);  Hang QI (Atlanta, Georgia);  Qiji ZE (Columbus, Ohio);  Shuai WU (Columbus, Ohio)
ABSTRACT Disclosed magnetic shape-memory compositions that comprise a polymer matrix and a population of hard-magnetic particles dispersed within the polymer matrix. In some embodiments, the magnetic shape-memory compositions can further comprise a population of auxiliary magnetic particles (e.g., ferrite particles) dispersed within the polymer matrix. The compositions can exhibit 1) reversible, fast, and controllable transforming deformation, 2) shape-locking, and 3) reprogramming capabilities.
FILED Friday, June 19, 2020
APPL NO 17/621150
CURRENT CPC
Compositions of Macromolecular Compounds
C08L 63/00 (20130101) Original (OR) Class
C08L 2201/12 (20130101)
C08L 2203/02 (20130101)
C08L 2207/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372423 Ingber et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
APPLICANT(S) PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts)
ASSIGNEE(S) PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts)
INVENTOR(S) Donald E. Ingber (Boston, Massachusetts);  Daniel LEVNER (Boston, Massachusetts);  Guy THOMPSON, III (Watertown, Massachusetts);  Jose FERNANDEZ-ALCON (Cambridge, Massachusetts);  Christopher David HINOJOSA (Cambridge, Massachusetts)
ABSTRACT Systems and methods interconnect cell culture devices and/or fluidic devices by transferring discrete volumes of fluid between devices. A liquid-handling system collects a volume of fluid from at least one source device and deposits the fluid into at least one destination device. In some embodiments, a liquid-handling robot actuates the movement and operation of a fluid collection device in an automated manner to transfer the fluid between the at least one source device and the at least one destination device. In some cases, the at least one source device and the at least one destination device are cell culture devices. The at least one source device and the at least one destination device may be microfluidic or non-microfluidic devices. In some cases, the cell culture devices may be microfluidic cell culture devices. In further cases, the microfluidic cell culture devices may include organ-chips.
FILED Friday, July 22, 2022
APPL NO 17/871054
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 3/0293 (20130101)
B01L 3/502715 (20130101)
B01L 2200/027 (20130101)

Apparatus for Enzymology or Microbiology;
C12M 21/08 (20130101)
C12M 23/16 (20130101)
C12M 23/38 (20130101)
C12M 23/58 (20130101)
C12M 29/00 (20130101)
C12M 29/10 (20130101) Original (OR) Class
C12M 29/20 (20130101)
C12M 37/04 (20130101)
C12M 41/48 (20130101)
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US 20220372585 Moon et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Complementary and Integrative Health (NCCIH)
National Science Foundation (NSF)
Directorate for Education and Human Resources (EHR)
Division of Graduate Education (DGE)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
Department of Agriculture (USDA)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) Tae Seok Moon (St. Louis, Missouri);  Hyojeong Yi (St. Louis, Missouri);  Matthew Amrofell (St. Louis, Missouri);  Chenggang Xi (St. Louis, Missouri);  Austin Rottinghaus (St. Louis, Missouri)
ASSIGNEE(S) Washington University (St. Louis, Missouri)
INVENTOR(S) Tae Seok Moon (St. Louis, Missouri);  Hyojeong Yi (St. Louis, Missouri);  Matthew Amrofell (St. Louis, Missouri);  Chenggang Xi (St. Louis, Missouri);  Austin Rottinghaus (St. Louis, Missouri)
ABSTRACT Among the various aspects of the present disclosure is the provision of molecular sensors, microbial sensors, constructs, systems, and methods for selectively detecting aromatic compounds.
FILED Wednesday, April 27, 2022
APPL NO 17/731195
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/02 (20130101)
C12Q 1/6897 (20130101) Original (OR) Class

Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms
C12R 2001/19 (20210501)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/9406 (20130101)
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US 20220372887 Dyer et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
APPLICANT(S) Raytheon Technologies Corporation (Farmington, Connecticut)
ASSIGNEE(S) Raytheon Technologies Corporation (Farmington, Connecticut)
INVENTOR(S) Timothy R. Dyer (North Haven, Connecticut);  Abhijeet Shrestha (Newington, Connecticut)
ABSTRACT A machine has: an outer member; an inner member mounted for rotation about an axis relative to the outer member; and a seal system. The seal system has: a seal housing mounted to the outer member; one or more seal rings held by the seal housing and having an inner diameter surface; and a seal runner mounted to the inner member and having a first outer diameter surface portion contacting or facing the inner diameter surface of the one or more seal rings. The seal runner has a circumferential array of mounting features. One or more weights are mounted to one or more of the mounting features.
FILED Wednesday, August 03, 2022
APPL NO 17/880074
CURRENT CPC
Non-positive Displacement Machines or Engines, e.g Steam Turbines
F01D 5/027 (20130101)
F01D 11/003 (20130101) Original (OR) Class

Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants
F02C 7/28 (20130101)

Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants
F05D 2230/60 (20130101)
F05D 2240/55 (20130101)
F05D 2260/15 (20130101)
F05D 2260/30 (20130101)
F05D 2300/226 (20130101)
F05D 2300/611 (20130101)
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US 20220373271 Miljkovic et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) The Board of Trustees of the University of Illinois (Urbana, Illinois)
ASSIGNEE(S)
INVENTOR(S) Nenad Miljkovic (Urbana, Illinois);  Nithin Vinod Upot (Urbana, Illinois);  Kazi Fazle Rabbi (Urbana, Illinois);  Anthony M. Jacobi (Mahomet, Illinois);  Allison J. Mahvi (Lakewood, Colorado)
ABSTRACT A method of achieving high heat transfer during cooling includes providing an aluminum body having an inner surface enclosing a channel, where the inner surface comprises microscale roughness features and microcavities configured to enhance nucleation site density during flow boiling. A refrigerant is transported through the channel. During the transport, the refrigerant absorbs heat from a thermal load and undergoes flow boiling. The heat is transferred to the refrigerant at an average heat transfer coefficient of at least about 10 kW/(m2·K) at a mass flux of about 300 kg/(m2·s).
FILED Wednesday, April 27, 2022
APPL NO 17/730502
CURRENT CPC
Refrigeration Machines, Plants or Systems; Combined Heating and Refrigeration Systems; Heat-pump Systems
F25B 9/006 (20130101)
F25B 41/40 (20210101)

Details of Heat-exchange and Heat-transfer Apparatus, of General Application
F28F 1/40 (20130101) Original (OR) Class
F28F 21/084 (20130101)
F28F 2260/02 (20130101)
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US 20220373299 Dwyer et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
APPLICANT(S) AimLock Inc. (Littleton, Colorado)
ASSIGNEE(S) AimLock Inc. (Littleton, Colorado)
INVENTOR(S) Benjamin Dwyer (Littleton, Colorado);  Bryan Sterling Bockmon (Littleton, Colorado);  Raymond Keeney (Littleton, Colorado);  Jason R. Gallia (Littleton, Colorado);  Shane Korthuis (Littleton, Colorado);  Dusty Terry (Littleton, Colorado);  Marc Hanchak (Littleton, Colorado)
ABSTRACT A weapon mount for controlling targeting of a weapon includes a base, an arm that extends from the base, and an attachment component that is rotatably coupled with the arm. The base is attachable to a platform and is rotatable to control a yaw of the weapon relative to the platform. The attachment component is configured to couple with the weapon and is rotatable to control a pitch of the weapon relative to the platform. The arm is positioned relative to the base so that a recoil vector of the weapon is within 0.5 inches radially of an axis of rotation of the base.
FILED Friday, March 11, 2022
APPL NO 17/693091
CURRENT CPC
Functional Features or Details Common to Both Smallarms and Ordnance, e.g Cannons; Mountings for Smallarms or Ordnance
F41A 23/06 (20130101)
F41A 23/52 (20130101)

Weapon Sights; Aiming
F41G 3/165 (20130101) Original (OR) Class
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US 20220373325 Ferro et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
APPLICANT(S) General Electric Company (Schenectady, New York)
ASSIGNEE(S)
INVENTOR(S) Andrew Frank Ferro (West Chester, Ohio);  Peter Coomes (Middletown, Ohio)
ABSTRACT A system for imaging a component defining a negative space is provided comprising a component imaging assembly, a bolus insert, and an imaging device. The bolus insert is positionable in the component's negative space when the component is positioned within an imaging device imaging field to produce a component image. A method is provided comprising positioning a bolus insert within a component's negative space and scanning the component having the bolus insert to create an image of the component. A component imaging assembly is provided comprising a component including a first portion having a first thickness that is greater than a second thickness of a second portion; and a bolus insert positioned adjacent the second portion that has a bolus thickness substantially similar to a difference between the first and second thicknesses. The bolus insert has a bolus material density within fifteen percent (15%) of a component material density.
FILED Friday, May 21, 2021
APPL NO 17/326778
CURRENT CPC
Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours
G01B 15/04 (20130101) Original (OR) Class

Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for
G01M 13/00 (20130101)
G01M 15/14 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220373395 Wilson et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
APPLICANT(S) U.S. Army Combat Capabilities Development Command, Army Research Laboratory (Adelphi, Maryland)
ASSIGNEE(S)
INVENTOR(S) Adam A. Wilson (Columbia, Maryland);  Dennis L. Waldron (Chesapeake Beach, Maryland);  Cory R. Knick (Troy, Ohio);  Darin J. Sharar (Silver Spring, Maryland)
ABSTRACT Sensor interconnects and supports and methods of making them utilize phonon disruptors for increased thermal resistance while maintaining acceptable electrical signal quality in materials. Phonon disruptors include the use of an electrically conductive alloy material or intermetallic material of at least two or more elements to promote scattering of phonons. These materials are selected to scatter heat carriers while allowing electrons to pass through the material.
FILED Tuesday, May 10, 2022
APPL NO 17/741185
CURRENT CPC
Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry
G01J 5/20 (20130101) Original (OR) Class
G01J 2005/0077 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220373409 Kolacz et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Naval Research Laboratory (NRL)
APPLICANT(S) The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
ASSIGNEE(S)
INVENTOR(S) Jakub Kolacz (Washington, District of Columbia);  Peter Finkel (Washington, District of Columbia);  Julia Pavlova (Washington, District of Columbia);  Christopher M. Spillmann (Washington, District of Columbia)
ABSTRACT Piezo-optic transducers convert variations in mechanical stress to a change in optical properties by coupling electro-optic and piezo-electric elements in a format suited to a single composite device without needing on-board electronics.
FILED Tuesday, May 03, 2022
APPL NO 17/735613
CURRENT CPC
Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure
G01L 1/16 (20130101) Original (OR) Class

Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters
G02F 1/11 (20130101)

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 41/1132 (20130101)
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US 20220373458 YOUSSEF et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
National Science Foundation (NSF)
APPLICANT(S) San Diego State University (SDSU) Fourndation, dba San Diego State University Research Foundation (San Diego, California)
ASSIGNEE(S)
INVENTOR(S) George YOUSSEF (Solana Beach, California);  Nha Uyen HUYNH (La Jolla, California)
ABSTRACT A testing apparatus for dynamic characterization of a sample of a material under test. A terahertz (THz) time-domain spectroscopy system is configured and arranged to generate and detect terahertz waves to interrogate the sample. A shock wave loading system is configured and arranged to produce a shock wave in the sample concurrently with said THz spectroscopy device interrogating the sample. The sample undergoes changes in an index of refraction in response to the produced ultrafast shock wave in the sample that are detected by the terahertz spectroscopy system.
FILED Friday, October 30, 2020
APPL NO 17/770277
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/41 (20130101)
G01N 21/3586 (20130101) Original (OR) Class
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US 20220373463 KELLEY et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Army Research Office (CCDC ARO)
National Science Foundation (NSF)
APPLICANT(S) UNIVERSITY OF SOUTH CAROLINA (COLUMBIA, South Carolina)
ASSIGNEE(S)
INVENTOR(S) MATHEW L. KELLEY (COLUMBIA, South Carolina);  ANDREW B. GREYTAK (COLUMBIA, South Carolina);  MVS CHANDRASHEKHAR (COLUMBIA, South Carolina)
ABSTRACT Spatially resolved Fourier Transform Impedance Spectroscopy (FTIS) is disclosed to spatially map and quickly build the frequency response of optoelectronic devices using optical probes. The transfer function of a linear system is the Fourier transform of its impulse response, which may be obtained from transient photocurrent measurements of devices such as photodetectors and solar cells. We apply FTIS to a PbS colloidal quantum dot (QD)/SiC heterojunction photodiode and corroborate results using intensity-modulated photocurrent spectroscopy. The cutoff frequencies of the QD/SiC devices were as high as ˜10 kHz, demonstrating their utility in advanced flexible and thin film electronics. The practical frequencies for FTIS lie in the mHz-kHz range, ideal for composite or novel materials such as QD films that are dominated by interfacial trap states.
FILED Monday, March 07, 2022
APPL NO 17/688230
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/6452 (20130101) Original (OR) Class
G01N 21/6456 (20130101)
G01N 2021/6423 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220373473 Steffan et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
APPLICANT(S) NOVI LLC (Arlington, Virginia)
ASSIGNEE(S)
INVENTOR(S) Scott Steffan (Hamburg, New York);  Constantine Papageorgiou (Needham, Massachusetts);  Amit Mehra (Arlington, Virginia)
ABSTRACT A system for taking high-resolution photographs from a vehicle-mounted camera, forming orthomosaics from video and/or multiple high-resolution photographs, and using artificial intelligence to detect and classify pavement flaws and defects in the imagery. Detection also includes the ability to capture quantifiable metrics for the defects and/or a region of interest. Three-dimensional imagery is produced from the same images as the orthomosaics. Surface and terrain map products made from the same source images capture additional details such as depth and volume. The highlighted orthomosaics and three-dimensional imagery can then be used as a basis to determine the pavement surface condition and subsequently support maintenance orders and manage pavement repairs. Further, metadata such as latitude, longitude, and altitude geo-location coordinates and sampling time can also be transferred to the output products to create a digital time history and enable analysis for preventative maintenance planning. Alternatively-sourced imagery may also be analyzed.
FILED Monday, October 04, 2021
APPL NO 17/493342
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/8851 (20130101) Original (OR) Class
G01N 2021/888 (20130101)
G01N 2021/889 (20130101)
G01N 2021/8861 (20130101)
G01N 2021/8874 (20130101)
G01N 2021/8877 (20130101)

Image Data Processing or Generation, in General
G06T 7/0002 (20130101)
G06T 2207/10004 (20130101)
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US 20220373529 Seifu
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
APPLICANT(S) Morgan State University (Baltimore, Maryland)
ASSIGNEE(S)
INVENTOR(S) Dereje Seifu (Towson, Maryland)
ABSTRACT Sensor and method for detecting, monitoring and/or removing trace amounts of heavy metal in a liquid. The sensor including magnetic nanoparticle composites of carbon nanotubes intercalated with CoFe2O4; the method including contacting a sample of liquid with the magnetic nanoparticle composites and measuring the X-ray diffraction and magnetic properties of the magnetic nanoparticle composite, where a statistical difference in the X-ray diffraction or magnetic properties of the magnetic nanoparticle composite before and after contact between said sample of said liquid and said magnetic nanoparticle composite indicates the presence of a heavy metal in said liquid.
FILED Friday, April 29, 2022
APPL NO 17/732975
CURRENT CPC
Treatment of Water, Waste Water, Sewage, or Sludge
C02F 1/62 (20130101)
C02F 1/288 (20130101)
C02F 2101/22 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 23/085 (20180201)
G01N 23/202 (20130101)
G01N 33/1813 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220373537 XU et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts);  THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts)
ASSIGNEE(S) TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts);  THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts)
INVENTOR(S) Ke XU (Cambridge, Massachusetts);  Marc E. LENBURG (Brookline, Massachusetts);  Ehab BILLATOS (Milton, Massachusetts);  Alejandro A. DIAZ (Boston, Massachusetts)
ABSTRACT Described herein are methods relating to the diagnosis, prognosis, and treatment of airway dysfunction, e.g., bronchiectasis by detecting gene expression in a sample obtained from a subject. Exemplary samples include a bronchial brushing, nasal brushing, sputum, or peripheral blood sample.
FILED Thursday, May 19, 2022
APPL NO 17/748404
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6883 (20130101)
C12Q 2539/10 (20130101)
C12Q 2600/118 (20130101)
C12Q 2600/158 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5023 (20130101) Original (OR) Class
G01N 2800/50 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220373543 Gopinath et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S) CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
ASSIGNEE(S)
INVENTOR(S) Ashwin Gopinath (Pasadena, California);  Paul W.K. Rothemund (Pasadena, California)
ABSTRACT Bistable devices are constructed using a polynucleotide platform for sensing molecular events such as binding or conformational changes of target molecules. Uses include measurement of target concentration, measuring the effect of environmental condition (such as heat, light, or pH) on the target, or screening a library for molecules that bind the target or modulate its biological function. Devices comprise three regions: a top lid, bottom lid, and flexible linker or hinge between them. A device has an open configuration in which the top and bottom lid are separated, and a closed configuration they are bound close together. Binding domains or variations of the target molecule are fixed to a device so that when the molecular event occurs, the device switches from open to closed, or vice versa, which generates a signal. Optimal device design is determined by the signal modality (optical or electronic) used to measure closure of surface-immobilized devices.
FILED Thursday, June 02, 2022
APPL NO 17/830901
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/11 (20130101)
C12N 2310/20 (20170501)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/47 (20130101)
G01N 21/553 (20130101)
G01N 21/6428 (20130101)
G01N 33/544 (20130101)
G01N 33/54373 (20130101) Original (OR) Class
G01N 2021/6439 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220373735 Safavi-Naeini et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
Defense Advanced Research Projects Agency (DARPA)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
APPLICANT(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)
INVENTOR(S) Amir H. Safavi-Naeini (Palo Alto, California);  Timothy Patrick McKenna (San Francisco, California);  Hubert S. Stokowski (Stanford, California)
ABSTRACT In an integrated optical device, squeezed light is used internally to effectively increase an optical modulation effect. One exemplary device operates by squeezing the light at the input, then sending it through an electro-optic stage where its phase picks up the signal of interest, and finally anti-squeezing it to obtain a displaced coherent state. Thus the displacement is amplified by the level of squeezing that is achieved inside the device and it is thereby less sensitive to loss. Since this device behaves simply as an electro-optic modulator, albeit one with an exponentially enhanced sensitivity, no extra considerations are needed to integrate the modulator into a system. Such devices can be operated as modulators or as sensors, and can make use of optical phase shift effects other than the electro-optic effect.
FILED Monday, May 09, 2022
APPL NO 17/740027
CURRENT CPC
Optical Elements, Systems, or Apparatus
G02B 6/12004 (20130101) Original (OR) Class
G02B 6/12007 (20130101)
G02B 6/29344 (20130101)
G02B 2006/1204 (20130101)
G02B 2006/12138 (20130101)
G02B 2006/12142 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220373747 Galvan
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Naval Surface Warfare Center (NSWC)
APPLICANT(S) The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
ASSIGNEE(S) The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
INVENTOR(S) Jaime Galvan (Bloomington, Indiana)
ABSTRACT Provided is a secure quick communication system disconnect switch box that enables remote verification of communication path connection or disconnection status. The box utilizes a lid having an affixed jumper circuit/assembly bridging or coupling at least two network connections. When the lid to the switch box is attached, the at least two computers/networks are connected via the jumper circuit/assembly. When the lid is removed from the switch box, the jumper circuit/assembly is disconnected from the at least two computer/networks, thereby disconnecting and isolating the otherwise coupled computers/networks. Removal of the lid additionally exposes network maintenance/access ports to provide access to one or more of the computers/network. When the lid is closed, the network maintenance/access ports are inaccessible to the user.
FILED Tuesday, May 17, 2022
APPL NO 17/746222
CURRENT CPC
Optical Elements, Systems, or Apparatus
G02B 6/3834 (20130101)
G02B 6/3897 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220373751 MAITI et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Army Research Office (CCDC ARO)
APPLICANT(S) The George Washington University (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Rishi MAITI (Washington, District of Columbia);  Volker SORGER (Alexandria, Virginia)
ABSTRACT A photonic device that includes two electrodes and a two-dimensional (2D) material electrically connecting the two electrodes. The 2D material may be molybdenum ditelluride. Strain may be induced in the 2D material (e.g., by placing the 2D material on a waveguide) to reduce the band gap of the 2D material and increase the efficiency of the photodetector. The photonic device may be a photodetector with 2D material that absorbs light energy and converts it into a photocurrent in a circuit that includes the two electrodes. The photonic device may be an emitter with 2D material that emits light energy in response to an electric field across the two electrodes. The photonic device may be a modulator with 2D material that modulates a property of an optical signal (e.g., the amplitude or phase) by modulating the amount of strain induced in the 2D material.
FILED Friday, November 20, 2020
APPL NO 17/771763
CURRENT CPC
Optical Elements, Systems, or Apparatus
G02B 6/4295 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220373763 Paranto et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) Applied Research Associates, Inc. (Albuquerque, New Mexico)
ASSIGNEE(S)
INVENTOR(S) Joseph N. Paranto (Albuquerque, New Mexico);  Michael E. Meline (Albuquerque, New Mexico);  Devin M.J. Todd (Orlando, Florida);  Matthew Flint Kepler (Austin, Texas);  Martin William Slack (Edgewood, New Mexico)
ABSTRACT Configurations and compositions for frameworks supporting optics such as lenses are described that provide an invariant structure regardless of temperature swings, thereby maintaining alignment and focus. Frameworks may comprise tiered structures of materials having multiple distinct coefficients of thermal expansion. An optical framework includes a first framework portion coupled to a first lens and a second framework portion coupled to a second lens. The first framework portion and second framework portion comprise materials having a coefficient of thermal expansion such that expansion of the first framework portion in one direction is offset by expansion of the second framework portion in an opposite direction.
FILED Thursday, May 20, 2021
APPL NO 17/325982
CURRENT CPC
Optical Elements, Systems, or Apparatus
G02B 7/008 (20130101)
G02B 7/021 (20130101)
G02B 7/028 (20130101) Original (OR) Class

Pictorial Communication, e.g Television
H04N 5/2254 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220373789 ARBABI et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
APPLICANT(S) Samsung Electronics Co., Ltd. (Suwon-si, South Korea);  California Institute of Technology (Pasadena, California)
ASSIGNEE(S) Samsung Electronics Co., Ltd. (Suwon-si, South Korea);  California Institute of Technology (Pasadena, California)
INVENTOR(S) Amir ARBABI (Pasadena, California);  Seunghoon Han (Seoul, South Korea);  Andrei Faraon (Pasadena, California)
ABSTRACT A focusing device includes a substrate and a plurality of scatterers provided at both sides of the substrate. The scatterers on the both sides of the focusing device may correct geometric aberration, and thus, a field of view (FOV) of the focusing device may be widened.
FILED Tuesday, July 26, 2022
APPL NO 17/874004
CURRENT CPC
Optical Elements, Systems, or Apparatus
G02B 3/0087 (20130101)
G02B 5/0263 (20130101)
G02B 5/0294 (20130101)
G02B 5/1876 (20130101)
G02B 5/3083 (20130101)
G02B 23/00 (20130101)
G02B 27/005 (20130101)
G02B 27/0031 (20130101) Original (OR) Class
G02B 27/0927 (20130101)
G02B 27/0955 (20130101)
G02B 27/4216 (20130101)
G02B 27/4272 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220373855 Yousefzadeh et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Research Laboratory (AFRL)
APPLICANT(S) Kent State University (Kent, Ohio);  Government of the United States as Represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
ASSIGNEE(S) Kent State University (Kent, Ohio);  Government of the United States as Represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
INVENTOR(S) Comrun Yousefzadeh (Kent, Ohio);  Philip Bos (Hudson, Ohio);  Andre Van Rynbach (Dayton, Ohio)
ABSTRACT Optical phase control elements are based on the Pancharatnam phase. Tunable liquid crystal devices containing the optical phase control elements may include a liquid crystal cell between a pair of substrates, a first plurality of electrodes, and a second plurality of electrodes. Each individual phase control element is defined by one electrode from the first plurality and one electrode from the second plurality.
FILED Tuesday, February 22, 2022
APPL NO 17/651925
CURRENT CPC
Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves
G01S 7/4817 (20130101)

Optical Elements, Systems, or Apparatus
G02B 26/08 (20130101)
G02B 27/283 (20130101)

Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters
G02F 1/29 (20130101) Original (OR) Class
G02F 2203/24 (20130101)
G02F 2203/50 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220374234 Imani
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Mohsen Imani (Irvine, California)
ABSTRACT Stochastic hyperdimensional arithmetic computing is provided. Hyperdimensional computing (HDC) is a neurally-inspired computation model working based on the observation that the human brain operates on high-dimensional representations of data, called hypervectors. Although HDC is powerful in reasoning and association of the abstract information, it is weak on feature extraction from complex data. Consequently, most existing HDC solutions rely on expensive pre-processing algorithms for feature extraction. This disclosure proposes StocHD, a novel end-to-end hyperdimensional system that supports accurate, efficient, and robust learning over raw data. StocHD expands HDC functionality to the computing area by mathematically defining stochastic arithmetic over HDC hypervectors. StocHD enables an entire learning application (including feature extractor) to process using HDC data representation, enabling uniform, efficient, robust, and highly parallel computation. This disclosure further provides a novel fully digital and scalable processing in-memory (PIM) architecture that exploits the HDC memory-centric nature to support extensively parallel computation.
FILED Friday, May 13, 2022
APPL NO 17/744371
CURRENT CPC
Electric Digital Data Processing
G06F 9/3001 (20130101)
G06F 9/3555 (20130101)
G06F 9/30036 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220374403 WANG et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) NVIDIA CORPORATION (Santa Clara, California)
ASSIGNEE(S)
INVENTOR(S) Hanrui WANG (Cambridge, Massachusetts);  James Michael O'CONNOR (Austin, Texas);  Donghyuk LEE (Cedar Park, Texas)
ABSTRACT One embodiment sets forth a technique for generating a tree structure within a computer memory for storing sparse data. The technique includes dividing a matrix into a first plurality of equally sized regions. The technique also includes dividing at least one region in the first plurality of regions into a second plurality of regions, where the second plurality of regions includes a first region and one or more second regions that have a substantially equal number of nonzero matrix values and are formed within the first region. The technique further includes creating the tree structure within the computer memory by generating a first plurality of nodes representing the first plurality of regions, generating a second plurality of nodes representing the second plurality of regions, and grouping, under a first node representing the first region, one or more second nodes representing the one or more second regions.
FILED Wednesday, May 19, 2021
APPL NO 17/325133
CURRENT CPC
Electric Digital Data Processing
G06F 16/2237 (20190101) Original (OR) Class
G06F 16/2246 (20190101)
G06F 16/2272 (20190101)
G06F 17/16 (20130101)

Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 9/6244 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220374496 WANG et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) NVIDIA CORPORATION (Santa Clara, California)
ASSIGNEE(S)
INVENTOR(S) Hanrui WANG (Cambridge, Massachusetts);  James Michael O'CONNOR (Austin, Texas);  Donghyuk LEE (Cedar Park, Texas)
ABSTRACT One embodiment sets forth a technique for performing one or more matrix multiplication operations based on a first matrix and a second matrix. The technique includes receiving data associated with the first matrix from a first traversal engine that accesses nonzero elements included in the first matrix via a first tree structure. The technique also includes performing one or more computations on the data associated with the first matrix and the data associated with the second matrix to produce a plurality of partial results. The technique further includes combining the plurality of partial results into one or more intermediate results and storing the one or more intermediate results in a first buffer memory.
FILED Wednesday, May 19, 2021
APPL NO 17/325120
CURRENT CPC
Electric Digital Data Processing
G06F 9/5072 (20130101)
G06F 16/9027 (20190101)
G06F 17/16 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220374606 Mosallanezhad et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Army Research Office (CCDC ARO)
Department of the Navy (DON)
Office of Naval Research (ONR)
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Information and Intelligent Systems (IIS)
APPLICANT(S) Ahmadreza Mosallanezhad (Tempe, Arizona);  Ghazaleh Beigi (Tempe, Arizona);  Huan Liu (Tempe, Arizona)
ASSIGNEE(S) Arizona Board of Regents on Behalf of Arizona State University (Tempe, Arizona)
INVENTOR(S) Ahmadreza Mosallanezhad (Tempe, Arizona);  Ghazaleh Beigi (Tempe, Arizona);  Huan Liu (Tempe, Arizona)
ABSTRACT Various embodiments of a system and associated method for anonymization of text without losing semantic utility of text by extracting a latent embedding representation of content with respect to a given task and by learning an optimal strategy for text embedding manipulation to satisfy both privacy and utility requirements are disclosed herein. In particular, the system balances private attribute obfuscation with retained semantic utility.
FILED Tuesday, November 16, 2021
APPL NO 17/527632
CURRENT CPC
Electric Digital Data Processing
G06F 40/30 (20200101) Original (OR) Class

Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 9/6262 (20130101)

Computer Systems Based on Specific Computational Models
G06N 20/00 (20190101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220374679 Bazhenov et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Maksim Bazhenov (San Diego, California);  Giri Prashanth Krishnan (San Diego, California);  Timothy Tadros (San Diego, California)
ABSTRACT Systems and methods for generating Artificial Neural Networks (ANNs) based on the principles of biological sleep are disclosed. Namely, the systems and methods can be configured to apply a sleep-like phase to ANNs which enables training to be generalized, performance to be improved, and catastrophic forgetting for sequential multi-task training to be prevented. Various implementations of these systems and methods can be configured to: (i) train an ANN using backpropagation algorithm, (ii) convert the architecture of the ANN to an equivalent Spiking Neural Network (SNN) and simulate a sleep phase in the SNN while using plasticity rules to modify synaptic weights, and (iii) convert the modified synaptic weights associated with the simulated sleep phase of the SNN back into the ANN. This transformation from ANN to SNN to ANN effectively emulates learning mechanisms actuated during biological sleep and, as such, overcomes limitations commonly associated with machine learning.
FILED Friday, July 17, 2020
APPL NO 17/627092
CURRENT CPC
Computer Systems Based on Specific Computational Models
G06N 3/049 (20130101) Original (OR) Class
G06N 3/084 (20130101)
G06N 3/0481 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220374759 Barnes et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Army Research Office (CCDC ARO)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (Blacksburg, Virginia)
ASSIGNEE(S)
INVENTOR(S) Edwin Barnes (Blacksburg, Virginia);  Junkai Zeng (Blacksburg, Virginia)
ABSTRACT Aspects of generating error-resistant quantum control pulses from geometrical curves are described. In some embodiments, a closed space curve is parameterized for a target gate operation of a quantum computing device. The closed space curve corresponds to an evolution operator of a time-dependent Schrödinger equation associated with the target gate operation. A control field definition is identified for the target gate operation based at least in part on a geometrical analysis of the evolution operator of the time-dependent Schrödinger equation. The target gate operation is implemented for the quantum computing device based on the control field definition.
FILED Friday, October 02, 2020
APPL NO 17/765875
CURRENT CPC
Computer Systems Based on Specific Computational Models
G06N 10/60 (20220101) Original (OR) Class

Pulse Technique
H03K 17/92 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220374961 Wang et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) NVIDIA CORPORATION (Santa Clara, California)
ASSIGNEE(S)
INVENTOR(S) Hanrui Wang (Cambridge, Massachusetts);  James Michael O'Connor (Austin, Texas);  Donghyuk Lee (Cedar Park, Texas)
ABSTRACT One embodiment sets forth a technique for performing matrix operations. The technique includes traversing a tree structure to access one or more non-empty regions within a matrix. The tree structure includes a first plurality of nodes and a second plurality of nodes corresponding to non-empty regions in the matrix. The first plurality of nodes includes a first node representing a first region and one or more second nodes that are children of the first node and represent second region(s) with an equal size formed within the first region. The second plurality of nodes include a third node representing a third region and one or more fourth nodes that are children of the third node and represent fourth region(s) with substantially equal numbers of non-zero matrix values formed within the third region. The technique also includes performing matrix operation(s) based on the non-empty region(s) to generate a matrix operation result.
FILED Wednesday, May 19, 2021
APPL NO 17/325116
CURRENT CPC
Electric Digital Data Processing
G06F 16/9027 (20190101)
G06F 17/16 (20130101)

Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for
G06Q 30/0631 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220375034 Bashkansky et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Naval Research Laboratory (NRL)
APPLICANT(S) The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
ASSIGNEE(S) The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
INVENTOR(S) Mark Bashkansky (Alexandria, Virginia);  Samuel Park (McLean, Virginia);  John F. Reintjes (Alexandria, Virginia)
ABSTRACT A method for using a single-pixel camera to reconstruct images of objects obscured by fog or other dynamic scattering media. A pseudo-random phase or intensity pattern is imposed on illumination beams directed at a target. The beam with the imposed pattern forms a pseudo random pattern on the target. Information regarding the pattern imposed on each pulse is entered into a data processor/controller. The illumination beams with the pseudo random patterns are reflected off the target, collected by receiving optics and a bucket detector and converted into electronic signals fed into the data processor/controller. The data processor/controller applies a high-pass filter to remove slower signal variations produced by dynamic changes in the scattering medium over time. The filtered bucket values are then used together with their corresponding speckle patterns to generate the images using any appropriate reconstruction algorithm such as CGI or CSI.
FILED Thursday, March 10, 2022
APPL NO 17/691172
CURRENT CPC
Image Data Processing or Generation, in General
G06T 5/001 (20130101) Original (OR) Class
G06T 5/10 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220375102 Grauman et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) Board of Regents, The University of Texas System (Austin, Texas)
ASSIGNEE(S)
INVENTOR(S) Kristen Grauman (Austin, Texas);  Suyog Dutt Jain (Boston, Massachusetts);  Bo Xiong (Austin, Texas)
ABSTRACT A method, system and computer program product for segmenting generic foreground objects in images and videos. For segmenting generic foreground objects in videos, an appearance stream of an image in a video frame is processed using a first deep neural network. Furthermore, a motion stream of an optical flow image in the video frame is processed using a second deep neural network. The appearance and motion streams are then joined to combine complementary appearance and motion information to perform segmentation of generic objects in the video frame. Generic foreground objects are segmented in images by training a convolutional deep neural network to estimate a likelihood that a pixel in an image belongs to a foreground object. After receiving the image, the likelihood that the pixel in the image is part of the foreground object as opposed to background is then determined using the trained convolutional deep neural network.
FILED Tuesday, August 02, 2022
APPL NO 17/879124
CURRENT CPC
Computer Systems Based on Specific Computational Models
G06N 3/0454 (20130101)

Image Data Processing or Generation, in General
G06T 7/11 (20170101)
G06T 7/143 (20170101)
G06T 7/194 (20170101) Original (OR) Class
G06T 7/215 (20170101)
G06T 2207/10016 (20130101)
G06T 2207/20076 (20130101)
G06T 2207/20081 (20130101)
G06T 2207/20084 (20130101)

Image or Video Recognition or Understanding
G06V 10/82 (20220101)
G06V 20/49 (20220101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220375214 Caulfield et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Research Laboratory (AFRL)
APPLICANT(S) Cyan Systems (Santa Barbara, California)
ASSIGNEE(S)
INVENTOR(S) John Caulfield (Santa Barbara, California);  Jon Paul Curzan (Arroyo Grande, California);  Kenton Veeder (Goleta, California)
ABSTRACT A mechanism for radiation detection is disclosed. An integrated circuit usable in detecting radiation includes a plurality of readout circuits is described. A readout circuit of the plurality of readout circuits includes an integration capacitor and an averaging capacitor. The integration capacitor is coupled with a pixel of a photodetector pixel array. The pixel has a pixel area. An available area less than the pixel area is usable for layout of the integration capacitor. The integration capacitor has a capacitor area less than the available area. The averaging capacitor has an averaging capacitance greater than the integration capacitance of the integration capacitor. In some aspects, the integrated circuit further includes at least one cascaded averaging circuit coupled with the averaging capacitor.
FILED Thursday, July 28, 2022
APPL NO 17/876265
CURRENT CPC
Image or Video Recognition or Understanding
G06V 10/94 (20220101) Original (OR) Class
G06V 10/7515 (20220101)

Pictorial Communication, e.g Television
H04N 5/33 (20130101)
H04N 5/341 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220375237 LIU et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
APPLICANT(S) Board of Trustees of Michigan State University (East Lansing, Michigan)
ASSIGNEE(S) Board of Trustees of Michigan State University (East Lansing, Michigan)
INVENTOR(S) Xiaoming LIU (Okemos, Michigan);  Abhinav KUMAR (East Lansing, Michigan);  Garrick BRAZIL (East Lansing, Michigan)
ABSTRACT An end-to-end trainable grouped mathematically differentiable non-maximal suppression (NMS) technique is presented for monocular 3D object detection. First, formulate NMS as a matrix operation and then group and mask the boxes in an unsupervised manner to obtain a simple closed-form expression of the NMS. This technique addresses the mismatch between training and inference pipelines and, therefore, forces the network to select the best 3D box in a differentiable manner. As a result, the proposed technique achieves state-of-the-art monocular 3D object detection results on the KITTI benchmark dataset performing comparably to monocular video-based methods.
FILED Tuesday, February 22, 2022
APPL NO 17/677193
CURRENT CPC
Image Data Processing or Generation, in General
G06T 7/73 (20170101)

Image or Video Recognition or Understanding
G06V 10/26 (20220101)
G06V 10/82 (20220101)
G06V 10/763 (20220101)
G06V 10/764 (20220101)
G06V 10/776 (20220101)
G06V 20/64 (20220101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220375754 Taylor et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
APPLICANT(S) U.S. Army DEVCOM, Army Research Laboratory (Adelphi, Maryland)
ASSIGNEE(S)
INVENTOR(S) Patrick J. Taylor (Oakton, Virginia);  George J. de Coster (Vienna, Virginia)
ABSTRACT A topological material includes a lattice crystalline structure; and a material defect in the lattice crystalline structure that is treatable by hydrogen passivation that chemically mitigates an electronic charge associated with the material defect. The lattice crystalline structure includes dangling bonds in an atomic arrangement of the material defect of the lattice crystalline structure, and the hydrogen passivation may apply hydrogen to chemically passivate the dangling bonds of the material defect. The hydrogen passivation may be achieved by diffusing hydrogen into common materials of the lattice crystalline structure. The hydrogen passivation may chemically and/or electrostatically neutralize an electronic activity associated with the material defect.
FILED Tuesday, May 18, 2021
APPL NO 17/323305
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 21/3003 (20130101) Original (OR) Class
H01L 29/04 (20130101)
H01L 43/02 (20130101)
H01L 43/12 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220376105 Guo et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
APPLICANT(S) Wolfspeed, Inc. (Durham, North Carolina)
ASSIGNEE(S)
INVENTOR(S) Jia Guo (Apex, North Carolina);  Saptharishi Sriram (Cary, North Carolina);  Scott Sheppard (Chapel Hill, North Carolina)
ABSTRACT A transistor device according to some embodiments includes a channel layer, a barrier layer on the channel layer, and source and drain contacts on the barrier layer, and a gate contact on the barrier layer between the source and drain contacts. The channel layer includes a sub-layer having an increased doping concentration level relative to a remaining portion of the channel layer. The presence of the sub-layer may reduce drain lag without substantially increasing gate lag.
FILED Thursday, May 20, 2021
APPL NO 17/325610
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 21/765 (20130101)
H01L 21/7605 (20130101)
H01L 29/404 (20130101)
H01L 29/2003 (20130101)
H01L 29/7787 (20130101) Original (OR) Class
H01L 29/66462 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220376157 Fish
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
APPLICANT(S) U.S. Army DEVCOM, Army Research Laboratory (Adelphi, Maryland)
ASSIGNEE(S)
INVENTOR(S) Michael C. Fish (Arlington, Virginia)
ABSTRACT A thermal energy storage (TES) device includes a thermoelectric cooler; and a metallic phase change material (PCM) within the thermoelectric cooler. The PCM may include any of gallium or its alloys, low temperature fusible alloys, and solid metal shape memory alloys. A thermoelectric effect within the PCM is to transport heat in the thermoelectric cooler. The TES device may include a graded oxide layer adjacent to the PCM to serve as a distributed electrical junction in the thermoelectric cooler to create a hot side thermoelectric junction in a bulk volume of the PCM. The graded oxide layer may include α-IGZO. The TES device may include a high-thermopower corrugated metal foil layer comprising barrier oxides patterned therein. The high-thermopower metal foil layer may be adjacent to the graded oxide layer. The TES device may include a dielectric layer adjacent to the high-thermopower corrugated metal foil layer.
FILED Thursday, December 09, 2021
APPL NO 17/546246
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 35/30 (20130101) Original (OR) Class
H01L 35/32 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220376315 Hammond et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Naval Surface Warfare Center (NSWC)
APPLICANT(S) The United States of America, as represented by the Secretary of the Navy (Crane, Indiana)
ASSIGNEE(S) The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
INVENTOR(S) Christopher J. Hammond (Bloomington, Indiana);  Alexander M. Potter (Bloomington, Indiana)
ABSTRACT Provided is a battery grid pellet adhesion/cohesion strength tester that can accurately determine the push-out strength of a battery grid pellet by measuring the binding of the active material to the battery grid during the pasting and curing process. A programmable test stand and force gage are used with a selectable active material punching tool fixture and a set of selectable set of grid location pins. Active material from a lead-acid battery is forced out of the battery grid at a programmed feed rate with the force gage reporting precise force measurements for each battery grid pellets adhesion/cohesion strength. The inventive device can be utilized as a quality control measure following the battery pasting and curing process, which will ensure that consistent and uniform adhesion/cohesion has occurred during battery manufacture, thereby avoiding battery premature performance failure.
FILED Wednesday, May 18, 2022
APPL NO 17/747267
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 19/04 (20130101)

Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 10/4285 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220376725 MEDARD et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts);  National University of Ireland, Maynooth (Maynooth, Ireland)
ASSIGNEE(S) Massachusetts Institute of Technology (Cambridge, Massachusetts);  National University of Ireland, Maynooth (Maynooth, Ireland)
INVENTOR(S) Muriel MEDARD (Belmont, Massachusetts);  Kenneth R. DUFFY (Burke, Virginia);  Amit SOLOMON (Cambridge, Massachusetts);  Alejandro COHEN (Brookline, Massachusetts)
ABSTRACT Described are concepts, systems, devices and methods that enhance decoding performance of channels subject to correlated noise. The concepts, systems, devices and methods can be used with any combination of codes, code-rates and decoding techniques. In embodiments, a continuous realization of effective noise is estimated from a lead channel by subtracting its decoded output from its received signal. This estimate is then used to improve the accuracy of decoding of an otherwise orthogonal channel that is experiencing correlated effective noise. In this approach, channels aid each other through the post-decoding provision of estimates of effective noise. In some embodiments, the lead channel is not pre-determined, but is chosen dynamically based on which of a plurality of decoders completes first, or using soft information including an estimate of effective noise that is least energetic or most likely to have occurred.
FILED Friday, July 22, 2022
APPL NO 17/814349
CURRENT CPC
Transmission
H04B 1/123 (20130101) Original (OR) Class
H04B 1/1027 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220376821 Hunter
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
The Aerospace Corporation (AEROSPACE)
Federally Funded Research and Development Center (FFRDC)
Operated by The Aerospace Corporation (AEROSPACE) at El Segundo, CA
APPLICANT(S) The Aerospace Corporation (El Segundo, California)
ASSIGNEE(S)
INVENTOR(S) Matthew Thomas Hunter (Ashburn, Virginia)
ABSTRACT System and methods are disclosed that comprise receiving at least one signal via a receiver. The at least one signal is extracted for data via a processor coupled to the receiver, wherein the data includes at least one message and a set of parameters related to the message. A signal output is generated using the at least one message and the set of parameters such that the signal output includes a first portion and a second portion. At least one error is identified in the signal output and corrected using the first portion and the second portion. An output is generated that is used to perform at least one task related to the at least one signal.
FILED Friday, May 21, 2021
APPL NO 17/327493
CURRENT CPC
Coding; Decoding; Code Conversion in General
H03M 13/2957 (20130101)

Transmission of Digital Information, e.g Telegraphic Communication
H04L 1/0005 (20130101)
H04L 1/0055 (20130101) Original (OR) Class

Wireless Communication Networks
H04W 4/90 (20180201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220377084 Zhang et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Army Research Office (CCDC ARO)
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computer and Network Systems (CNS)
APPLICANT(S) Cornell University (Ithaca, New York)
ASSIGNEE(S)
INVENTOR(S) Fan Zhang (New York, New York);  Sai Krishna Deepak Maram (New York, New York);  Harjasleen Malvai (Ithaca, New York);  Steven Goldfeder (Spring Valley, New York);  Ari Juels (New York, New York)
ABSTRACT A verifier device in one embodiment is configured to communicate over one or more networks with a client device and a server device. The verifier device participates in a three-party handshake protocol with the client device and the server device in which the verifier device and the client device obtain respective shares of a session key of a secure session with the server device. The verifier device receives from the client device a commitment relating to the secure session with the server device, and responsive to receipt of the commitment, releases to the client device additional information relating to the secure session that was not previously accessible to the client device. The verifier device verifies correctness of at least one characterization of data obtained by the client device from the server device as part of the secure session, based at least in part on the commitment and the additional information.
FILED Friday, August 28, 2020
APPL NO 17/636402
CURRENT CPC
Transmission of Digital Information, e.g Telegraphic Communication
H04L 63/126 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Energy (DOE) 

US 20220370086 Szafron et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Lawrence Livermore National Laboratory (LLNL)
Federally Funded Research and Development Center (FFRDC)
Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) Lawrence Livermore National Security, LLC (Livermore, California);  The Texas A and M University System (College Statin, Texas)
ASSIGNEE(S)
INVENTOR(S) Jason Szafron (Hamden, Connecticut);  Duncan Maitland (College Station, Texas);  Ward Small, IV (Livermore, California);  Patrick R. Buckley (Livermore, California);  Andrea D. Muschenborn (Bloomington, Indiana)
ABSTRACT An embolectomy device comprised of an expansion unit and a support unit is disclosed. The expansion unit can be actuated in response to one or more external stimuli, and the support unit, located proximately to the expansion unit, provides a force to hold the expansion unit in place and to further induce the expansion unit's radial expansion. The radial expansion of the expansion unit causes the expansion unit to physically contact a blood clot, enabling the blood clot to be removed. In some embodiments, the expansion unit can be fabricated from a shape memory polymer foam. In some embodiments the support unit can be fabricated from any elastic material including, without limitation, shape memory alloys.
FILED Friday, August 05, 2022
APPL NO 17/881684
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 17/22 (20130101) Original (OR) Class
A61B 2017/2212 (20130101)
A61B 2017/22094 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370960 Nair et al.
FUNDED BY
Department of Energy (DOE)
APPLICANT(S) Georgia Tech Research Corporation (Atlanta, Georgia)
ASSIGNEE(S)
INVENTOR(S) Sankar Nair (Atlanta, Georgia);  Chen Ma (Atlanta, Georgia);  Meisha Shofner (Atlanta, Georgia);  Scott Sinquefield (Atlanta, Georgia);  Zhongzhen Wang (Atlanta, Georgia)
ABSTRACT Disclosed herein are membranes comprising: porous substrate; and two or more graphene oxide (GO) sheets disposed on the porous substrate, each GO layer comprising a plurality of GO flakes, each GO flake comprising a planar graphene structure with oxygen moieties extending therefrom, wherein the membrane, when a pressure from 10 bar to 50 bar of transmembrane pressure is applied from 1 hour to 48 hours, has an aqueous flux wherein the aqueous flux changes by 5% or less while the pressure is applied. The membranes can also include an intercalating agent disposed between the two or more GO sheets, the intercalating agent interacting with each GO sheet, wherein the intercalating agent provides a non-covalent stabilization of the two or more GO sheets. Also disclosed herein are methods of making and using the same and systems for implementing the same.
FILED Friday, May 22, 2020
APPL NO 17/612530
CURRENT CPC
Separation
B01D 67/00416 (20220801) Original (OR) Class
B01D 69/10 (20130101)
B01D 69/1213 (20220801)
B01D 71/0211 (20220801)

Treatment of Water, Waste Water, Sewage, or Sludge
C02F 1/44 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220371057 Kumar et al.
FUNDED BY
Department of Energy (DOE)
Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S) Sortera Alloys, Inc. (Fort Worth, Texas)
ASSIGNEE(S) Sortera Alloys, Inc. (Fort Worth, Texas)
INVENTOR(S) Nalin Kumar (Fort Worth, Texas);  Manuel Gerardo Garcia, JR. (Fort Wayne, Indiana)
ABSTRACT A system classifies materials utilizing a vision system that implements an artificial intelligence system in order to identify or classify and then remove automotive airbag modules from a scrap stream, which may have been produced from a shredding of end-of-life vehicles. The sorting process may be designed so that live airbag modules are not activated, which may cause damage to equipment or persons.
FILED Friday, August 05, 2022
APPL NO 17/882506
CURRENT CPC
Postal Sorting; Sorting Individual Articles, or Bulk Material Fit to be Sorted Piece-meal, e.g by Picking
B07C 5/12 (20130101)
B07C 5/3422 (20130101) Original (OR) Class
B07C 2501/0036 (20130101)
B07C 2501/0054 (20130101)

Image Data Processing or Generation, in General
G06T 7/0004 (20130101)
G06T 7/10 (20170101)
G06T 2207/20084 (20130101)

Image or Video Recognition or Understanding
G06V 10/82 (20220101)
G06V 10/765 (20220101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220371067 Whalen et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Pacific Northwest National Laboratory (PNNL)
Federally Funded Research and Development Center (FFRDC)
Operated by Battelle Memorial Institute (BMI) at Richland, WA
APPLICANT(S) Battelle Memorial Institute (Richland, Washington)
ASSIGNEE(S) Battelle Memorial Institute (Richland, Washington)
INVENTOR(S) Scott A. Whalen (West Richland, Washington);  Darrell R. Herling (Kennewick, Washington);  Xiao Li (Richland, Washington);  MD. Reza-E-Rabby (Richland, Washington);  Brandon Scott Taysom (West Richland, Washington);  Glenn J. Grant (Benton City, Washington)
ABSTRACT Shear-assisted extrusion processes for forming extrusions of a desired composition from a feedstock material are provided. The processes can include applying a rotational shearing force and an axial extrusion to the same location on the feedstock material. Devices for this can include a die tool defined by a die face extending from a rim of the die face inwardly at an angle greater than zero in relation to a sidewall of the die tool in at least one cross section; and/or a die tool defining an opening configured to receive feedstock material for extrusion and further defining a die face defining a recess within the die face and contiguous with the opening. Shear-assisted extrusion processes are also provided that can mix different portions of the feedstock material within a recess about the opening prior to feedstock material entering the opening; and extruding the mixed portions.
FILED Tuesday, July 26, 2022
APPL NO 17/874140
CURRENT CPC
Manufacture of Metal Sheets, Wire, Rods, Tubes or Profiles, Otherwise Than by Rolling; Auxiliary Operations Used in Connection With Metal-working Without Essentially Removing Material
B21C 23/085 (20130101)
B21C 25/02 (20130101) Original (OR) Class
B21C 25/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220371094 Bhattad et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Oak Ridge National Laboratory (ORNL)
Federally Funded Research and Development Center (FFRDC)
Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S) Carl Zeiss Industrial Metrology, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S) UT-Battelle, LLC (Oak Ridge, Tennessee)
INVENTOR(S) Pradeep Bhattad (Knoxville, Tennessee);  Paul Brackman (Knoxville, Tennessee);  Curtis Frederick (Knoxville, Tennessee);  Marcin B. Bauza (Plymouth, Minnesota);  Edson Costa Santos (Oberkochen, Germany);  Ryan Dehoff (Knoxville, Tennessee);  Alex Plotkowski (Knoxville, Tennessee);  Aleksandr Lisovich (Plymouth, Minnesota);  Jason James Tenboer (Elk River, Minnesota)
ABSTRACT An apparatus includes a control system that defines a test part having multiple features of multiple feature types. The control system controls an additive manufacturing (AM) machine to print multiple copies of the test part, with each copy being printed according to a respective set of values used as printing parameters. A measurement system obtains a computed tomography (CT) image of each of the copies of the test part. An analysis system, for each of the plurality of feature types, analyzes the CT images to identify a selected set of values for the printing parameters. The analysis system identifies a portion of the CT image related to a first feature and assesses its density based on an average grayscale value. The AM machine is then controlled to print production parts according to, for each feature type of the production parts, the selected set of values for the printing parameters.
FILED Wednesday, November 18, 2020
APPL NO 17/777598
CURRENT CPC
Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder
B22F 10/28 (20210101)
B22F 10/85 (20210101) Original (OR) Class
B22F 12/90 (20210101)

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 10/00 (20141201)
B33Y 30/00 (20141201)
B33Y 50/02 (20141201)

Image Data Processing or Generation, in General
G06T 7/0006 (20130101)
G06T 7/337 (20170101)
G06T 11/005 (20130101)
G06T 2207/30144 (20130101)

Image or Video Recognition or Understanding
G06V 10/44 (20220101)
G06V 30/18019 (20220101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220371266 Huang et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S) CORNELL UNIVERSITY (Ithaca, New York)
ASSIGNEE(S)
INVENTOR(S) Jen-Yu Huang (Ithaca, New York);  Tangi Aubert (Ithaca, New York);  Tobias Hanrath (Ithaca, New York);  Ulrich B. Wiesner (Ithaca, New York)
ABSTRACT Provided are compositions that may be referred to as photoreactive compositions or inks. The compositions may have a plurality of reactive components, which are silica nanocages with one or more photoreactive ligand(s). Also provided are methods of making an article of manufacture. Also provided are articles of manufacture and uses thereof. The article of manufacture may be formed from a composition of the present disclosure.
FILED Monday, November 02, 2020
APPL NO 17/772178
CURRENT CPC
Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 64/153 (20170801) Original (OR) Class

Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts
B29K 2509/00 (20130101)

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 10/00 (20141201)
B33Y 70/00 (20141201)
B33Y 80/00 (20141201)

Non-metallic Elements; Compounds Thereof;
C01B 33/12 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220371280 Barocio et al.
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S) Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S) Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S) Eduardo Barocio (West Lafayette, Indiana);  Jorge A. Ramirez (West Lafayette, Indiana);  Miguel Angel Ramirez (Lafayette, Indiana);  Bastian Brenken (Nottensdorf, Germany);  Robert Byron Pipes (Lafayette, Indiana)
ABSTRACT A method of depositing a multiphase material. The method includes providing a Continuous Multifunctional Composite (CMC) phase containing at least one continuous element in a polymeric matrix, passing the CMC phase through a feeding system containing a cutting system, producing a predetermined length of the CMC phase, providing a flow a molten polymer such that the molten polymer and the CMC phase are merged into a continuous co-extrusion nozzle so as to produce a co-extruded multiphase material, and depositing the co-extruded multiphase material onto a surface. An apparatus for depositing a multiphase material. The apparatus contains a co-extrusion nozzle, a means to introduce a CMC phase and a molten polymer into the co-extrusion nozzle, such that the molten polymer and the CMC phase are co-extruded and deposited on a surface. An article containing a CMC phase containing continuous elements embedded in a polymer resin forming a multiphase structure.
FILED Sunday, January 02, 2022
APPL NO 17/567141
CURRENT CPC
Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 64/118 (20170801)
B29C 64/209 (20170801)
B29C 64/336 (20170801) Original (OR) Class

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 10/00 (20141201)
B33Y 30/00 (20141201)
B33Y 40/00 (20141201)
B33Y 70/00 (20141201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220371281 Barocio et al.
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S) Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S) Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S) Eduardo Barocio (West Lafayette, Indiana);  Jorge A. Ramirez (West Lafayette, Indiana);  Miguel Angel Ramirez (Lafayette, Indiana);  Bastian Brenken (Nottensdorf, Germany);  Robert Byron Pipes (Lafayette, Indiana)
ABSTRACT A method of depositing a multiphase material. The method includes providing a Continuous Multifunctional Composite (CMC) phase containing at least one continuous element in a polymeric matrix, passing the CMC phase through a feeding system containing a cutting system, producing a predetermined length of the CMC phase, providing a flow a molten polymer such that the molten polymer and the CMC phase are merged into a continuous co-extrusion nozzle so as to produce a co-extruded multiphase material, and depositing the co-extruded multiphase material onto a surface. An apparatus for depositing a multiphase material. The apparatus contains a co-extrusion nozzle, a means to introduce a CMC phase and a molten polymer into the co-extrusion nozzle, such that the molten polymer and the CMC phase are co-extruded and deposited on a surface. An article containing a CMC phase containing continuous elements embedded in a polymer resin forming a multiphase structure.
FILED Sunday, January 02, 2022
APPL NO 17/567143
CURRENT CPC
Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 64/118 (20170801)
B29C 64/209 (20170801)
B29C 64/336 (20170801) Original (OR) Class

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 10/00 (20141201)
B33Y 30/00 (20141201)
B33Y 40/00 (20141201)
B33Y 70/00 (20141201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220371282 Barocio et al.
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S) Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S) Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S) Eduardo Barocio (West Lafayette, Indiana);  Jorge A. Ramirez (West Lafayette, Indiana);  Miguel Angel Ramirez (Lafayette, Indiana);  Bastian Brenken (Nottensdorf, Germany);  Robert Byron Pipes (Lafayette, Indiana)
ABSTRACT A method of depositing a multiphase material. The method includes providing a Continuous Multifunctional Composite (CMC) phase containing at least one continuous element in a polymeric matrix, passing the CMC phase through a feeding system containing a cutting system, producing a predetermined length of the CMC phase, providing a flow a molten polymer such that the molten polymer and the CMC phase are merged into a continuous co-extrusion nozzle so as to produce a co-extruded multiphase material, and depositing the co-extruded multiphase material onto a surface. An apparatus for depositing a multiphase material. The apparatus contains a co-extrusion nozzle, a means to introduce a CMC phase and a molten polymer into the co-extrusion nozzle, such that the molten polymer and the CMC phase are co-extruded and deposited on a surface. An article containing a CMC phase containing continuous elements embedded in a polymer resin forming a multiphase structure.
FILED Sunday, January 02, 2022
APPL NO 17/567146
CURRENT CPC
Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 64/118 (20170801)
B29C 64/209 (20170801)
B29C 64/336 (20170801) Original (OR) Class

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 10/00 (20141201)
B33Y 30/00 (20141201)
B33Y 40/00 (20141201)
B33Y 70/00 (20141201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220371896 Zeller et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) H QUEST VANGUARD, INC. (Pittsburgh, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Kurt W. Zeller (Pittsburgh, Pennsylvania);  George L. Skoptsov (Pittsburgh, Pennsylvania);  Evan T. Musselman (Pittsburgh, Pennsylvania)
ABSTRACT Systems and methods for plasma based synthesis of graphitic materials. The system includes a plasma forming zone configured to generate a plasma from radio-frequency radiation, an interface element configured to transmit the plasma from the plasma forming zone to a reaction zone, and the reaction zone configured to receive the plasma. The reaction zone is further configured to receive feedstock material comprising a carbon containing species, and convert the feedstock material to a product comprising the graphitic materials in presence of the plasma.
FILED Monday, June 13, 2022
APPL NO 17/806619
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 19/088 (20130101)
B01J 19/126 (20130101)
B01J 19/129 (20130101)
B01J 2219/0875 (20130101)
B01J 2219/0894 (20130101)
B01J 2219/0896 (20130101)
B01J 2219/0898 (20130101)

Non-metallic Elements; Compounds Thereof;
C01B 32/184 (20170801) Original (OR) Class

Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams
H05H 1/30 (20130101)
H05H 1/4622 (20210501)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220371918 Shabgard et al.
FUNDED BY
Department of Energy (DOE)
Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S) The Board of Regents of the University of Oklahoma (Norman, Oklahoma)
ASSIGNEE(S) The Board of Regents of the University of Oklahoma (Norman, Oklahoma)
INVENTOR(S) Hamidreza Shabgard (Norman, Oklahoma);  Ramkumar Parthasarathy (Norman, Oklahoma);  Jie Cai (Norman, Oklahoma);  Reza Kaviani (Norman, Oklahoma);  Aly Elhefny (Norman, Oklahoma)
ABSTRACT A water treatment system is configured to remove salt from a feed brine. The water treatment system includes a primary freezing chamber configured to receive the feed brine and a source of cooled intermediate cold liquid connected to the primary freezing chamber. The cooled intermediate cold liquid and feed brine are mixed within the primary freezing chamber, where ice particles are formed. The water treatment system includes a rotary separator connected to a discharge from the primary freezing chamber. The rotary separator is configured to separate solid ice particles from liquid components in the discharge from the primary freezing chamber. In some embodiments, the rotary separator includes a mesh inner filter tube that is configured for rotation within a solid outer filter tube, where the mesh inner filter tube allows liquid components to drain into the outer filter tube while conveying solid ice particles to an ice recovery tank.
FILED Friday, May 20, 2022
APPL NO 17/750113
CURRENT CPC
Treatment of Water, Waste Water, Sewage, or Sludge
C02F 1/001 (20130101)
C02F 1/22 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220371970 Bukovsky et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Lawrence Livermore National Laboratory (LLNL)
Federally Funded Research and Development Center (FFRDC)
Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S) LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California)
ASSIGNEE(S)
INVENTOR(S) Eric V. Bukovsky (Livermore, California);  Karl Thomas Lorenz (Livermore, California);  Robert V. Reeves (Livermore, California);  Harry K. Springer (Pleasanton, California)
ABSTRACT An explosive with reduced detonation performance that includes an explosive powder that detonates with a reaction velocity of less than 5000 feet per second, a polymer resin, and an inert filler.
FILED Friday, May 21, 2021
APPL NO 17/326863
CURRENT CPC
Explosives or Thermic Compositions; Manufacture Thereof; Use of Single Substances as Explosives
C06B 21/0058 (20130101)
C06B 25/00 (20130101)
C06B 25/32 (20130101)
C06B 25/34 (20130101)
C06B 45/10 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220371971 VARDON et al.
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
National Renewable Energy Laboratory (NREL)
Federally Funded Research and Development Center (FFRDC)
Operated by Alliance for Sustainable Energy, LLC (ASE) at Golden, CO
APPLICANT(S) Alliance for Sustainable Energy, LLC (Golden, Colorado)
ASSIGNEE(S)
INVENTOR(S) Derek Richard VARDON (Lakewood, Colorado);  Xiangchen HUO (Golden, Colorado);  Nabila HUQ (Golden, Colorado);  Huong Thi Thanh NGUYEN (Arvada, Colorado)
ABSTRACT The present disclosure relates to a method that includes a first treating of a first mixture that includes a carboxylic acid having between 2 and 12 carbon atoms, inclusively, to form a second mixture that includes a ketone having between 2 and 25 carbon atoms, inclusively, and a second treating of at least a first portion of the second mixture to form a first product that includes a paraffin having 8 or more carbon atoms.
FILED Tuesday, July 12, 2022
APPL NO 17/862542
CURRENT CPC
Acyclic or Carbocyclic Compounds
C07C 1/22 (20130101) Original (OR) Class
C07C 9/15 (20130101)
C07C 9/16 (20130101)
C07C 45/41 (20130101)
C07C 45/68 (20130101)

Fuels Not Otherwise Provided for; Natural Gas; Synthetic Natural Gas Obtained by Processes Not Covered by Subclasses C10G, C10K; Liquefied Petroleum Gas; Adding Materials to Fuels or Fires to Reduce Smoke or Undesirable Deposits or to Facilitate Soot Removal; Firelighters
C10L 1/04 (20130101)
C10L 2200/0469 (20130101)
C10L 2270/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372373 Elliott et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Pacific Northwest National Laboratory (PNNL)
Federally Funded Research and Development Center (FFRDC)
Operated by Battelle Memorial Institute (BMI) at Richland, WA
APPLICANT(S) Battelle Memorial Institute (Richland, Washington)
ASSIGNEE(S) Battelle Memorial Institute (Richland, Washington)
INVENTOR(S) Douglas C. Elliott (Richland, Washington);  Gary G. Neuenschwander (Burbank, Washington);  Todd R. Hart (Kennewick, Washington)
ABSTRACT A combined hydrothermal liquefaction (HTL) and catalytic hydrothermal gasification (CHG) system and process are described that convert various biomass-containing sources into separable bio-oils and aqueous effluents that contain residual organics. Bio-oils may be converted to useful bio-based fuels and other chemical feedstocks. Residual organics in HTL aqueous effluents may be gasified and converted into medium-BTU product gases and directly used for process heating or to provide energy.
FILED Wednesday, July 27, 2022
APPL NO 17/875269
CURRENT CPC
Destructive Distillation of Carbonageous Materials for Production of Gas, Coke, Tar, or Similar Materials
C10B 49/16 (20130101) Original (OR) Class

Cracking Hydrocarbon Oils; Production of Liquid Hydrocarbon Mixtures, e.g by Destructive Hydrogenation, Oligomerisation, Polymerisation; Recovery of Hydrocarbon Oils From Oil-shale, Oil-sand, or Gases; Refining Mixtures Mainly Consisting of Hydrocarbons; Reforming of Naphtha; Mineral Waxes
C10G 1/06 (20130101)
C10G 1/065 (20130101)
C10G 3/40 (20130101)
C10G 3/50 (20130101)

Production of Producer Gas, Water-gas, Synthesis Gas From Solid Carbonaceous Material, or Mixtures Containing These Gases; Carburetting Air or Other Gases
C10J 3/00 (20130101)
C10J 2200/06 (20130101)
C10J 2300/0916 (20130101)
C10J 2300/0973 (20130101)
C10J 2300/1681 (20130101)

Fuels Not Otherwise Provided for; Natural Gas; Synthetic Natural Gas Obtained by Processes Not Covered by Subclasses C10G, C10K; Liquefied Petroleum Gas; Adding Materials to Fuels or Fires to Reduce Smoke or Undesirable Deposits or to Facilitate Soot Removal; Firelighters
C10L 3/08 (20130101)
C10L 9/08 (20130101)
C10L 9/086 (20130101)

Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution
Y02E 50/10 (20130101)

Climate Change Mitigation Technologies in the Production or Processing of Goods
Y02P 20/145 (20151101)
Y02P 30/20 (20151101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372429 Pinowska et al.
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S) Global Algae Technology, LLC (Santee, California)
ASSIGNEE(S)
INVENTOR(S) Agnieszka Pinowska (San Diego, California);  Rodney Corpuz (Lihue, Hawaii);  David A. Hazlebeck (El Cajon, California)
ABSTRACT A method of autotrophic cultivation of algae includes cultivating algae in the presence of cultivation media and at least one growth nutrient to produce an algal biomass; and harvesting the algal biomass by separating the algal biomass from the cultivation media and the at least one growth nutrient. The algal biomass comprises at least 35% fatty acid lipid content and at least 30% protein content on an ash-free dry weight basis
FILED Tuesday, May 17, 2022
APPL NO 17/746448
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 1/02 (20130101)
C12N 1/12 (20130101) Original (OR) Class
C12N 1/38 (20130101)

Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms
C12R 2001/89 (20210501)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372526 Hamberger et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
National Science Foundation (NSF)
Directorate for Biological Sciences (BIO)
Division of Environmental Biology (DEB)
APPLICANT(S) Board of Trustees of Michigan State University (East Lansing, Michigan)
ASSIGNEE(S)
INVENTOR(S) Björn Hamberger (Okemos, Michigan);  Sean Johnson (Bedford, Massachusetts);  Wajid Waheed Bhat (Srinagar, J&K, India)
ABSTRACT Enzymes and methods are described herein for manufacturing terpenes, including terpenes.
FILED Friday, August 02, 2019
APPL NO 17/265482
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/1022 (20130101)
C12N 9/1085 (20130101)
C12N 15/8243 (20130101)

Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture
C12P 5/002 (20130101) Original (OR) Class
C12P 17/02 (20130101)
C12P 17/06 (20130101)

Enzymes
C12Y 202/01007 (20130101)
C12Y 205/01029 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372630 Jordan et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
APPLICANT(S) The University of Connecticut (Farmington, Connecticut)
ASSIGNEE(S)
INVENTOR(S) Eric Jordan (Storrs, Connecticut);  Maurice Gell (Somerset, New Jersey);  Rishi Kumar (Ashford, Connecticut);  Chen Jiang (Willimantic, Connecticut)
ABSTRACT A coating on a substrate is disclosed having layers including yttrium aluminum garnet (YAG) and yttrium aluminum monoclinic (YAM).
FILED Monday, August 01, 2022
APPL NO 17/878868
CURRENT CPC
Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General
C23C 28/042 (20130101)
C23C 28/044 (20130101)
C23C 28/3455 (20130101) Original (OR) Class

Non-positive Displacement Machines or Engines, e.g Steam Turbines
F01D 5/288 (20130101)

Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants
F05D 2230/90 (20130101)
F05D 2260/95 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372638 He et al.
FUNDED BY
Department of Energy (DOE)
Office of Nuclear Energy (DOE-NE)
Idaho National Laboratory (INL)
Federally Funded Research and Development Center (FFRDC)
Operated by Battelle Energy Alliance, LLC (BEA) at Idaho Falls, ID
APPLICANT(S) Battelle Energy Alliance, LLC (Idaho Falls, Idaho)
ASSIGNEE(S)
INVENTOR(S) Ting He (Idaho Falls, Idaho);  Dong Ding (Idaho Falls, Idaho);  Chenlin Li (Idaho Falls, Idaho)
ABSTRACT A method of carbon dioxide hydrogenation comprises introducing gaseous water to a positive electrode of an electrolysis cell comprising the positive electrode, a negative electrode, and a proton-conducting membrane between the positive electrode and the negative electrode. The proton-conducting membrane comprises an electrolyte material having an ionic conductivity greater than or equal to about 10−2 S/cm at one or more temperatures within a range of from about 150° C. to about 650° C. Carbon dioxide is introduced to the negative electrode of the electrolysis cell. A potential difference is applied between the positive electrode and the negative electrode of the electrolysis cell to generate hydrogen ions from the gaseous water that diffuses through the proton-conducting membrane and hydrogenates the carbon dioxide at the negative electrode. A carbon dioxide hydrogenation system is also described.
FILED Wednesday, July 27, 2022
APPL NO 17/815504
CURRENT CPC
Non-metallic Elements; Compounds Thereof;
C01B 3/045 (20130101)
C01B 2203/067 (20130101)
C01B 2203/0272 (20130101)

Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor
C25B 3/25 (20210101) Original (OR) Class
C25B 9/23 (20210101)
C25B 11/04 (20130101)
C25B 13/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372642 REN et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
APPLICANT(S) University of Houston System (Houston, Texas)
ASSIGNEE(S) University of Houston System (Houston, Texas)
INVENTOR(S) Zhifeng REN (Pearland, Texas);  Fang YU (Houston, Texas);  Haiqing ZHOU (Houston, Texas);  Shuo CHEN (Houston, Texas)
ABSTRACT A method of manufacturing a bifunctional electrocatalyst for overall water splitting comprising oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) by growing electrocatalyst comprising primarily metallic phosphides on three-dimensional substrate by: immersing the substrate in an iron nitrate solution to form a once disposed substrate; subjecting the once disposed substrate to thermal phosphidation with phosphorus powder under inert gas to grow metal phosphides thereupon and form a once subjected substrate; cooling the once subjected substrate to form a cooled, once subjected substrate; immersing the cooled, once subjected substrate in an iron nitrate solution to form a twice disposed substrate; and subjecting the twice disposed substrate to thermal phosphidation with phosphorus powder under inert gas to provide an electrode comprising the bifunctional electrocatalyst on the three-dimensional substrate. An electrode for overall water splitting having a substrate and a bifunctional electrocatalyst comprising primarily metallic phosphides on a surface of the substrate.
FILED Tuesday, May 31, 2022
APPL NO 17/828172
CURRENT CPC
Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General
C23C 16/18 (20130101)
C23C 16/30 (20130101)
C23C 16/045 (20130101)

Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor
C25B 1/04 (20130101)
C25B 11/061 (20210101)
C25B 11/075 (20210101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220373137 Elgowainy et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Argonne National Laboratory (ANL)
Federally Funded Research and Development Center (FFRDC)
Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
APPLICANT(S) UChicago Argonne, LLC (Chicago, Illinois)
ASSIGNEE(S)
INVENTOR(S) Amgad A. Elgowainy (Lisle, Illinois);  Krishna R. Reddi (Bolingbrook, Illinois)
ABSTRACT A method and a precooling system are provided for precooling gaseous fuel supplied for fueling pressurized gaseous vehicle onboard storage tank systems. The precooling system is used in pressurized gaseous fueling stations with source fuels in cryogenic state, such as liquid hydrogen (LH2) and liquefied nature gas (LNG). A thermal buffer heat exchanger includes a heat exchanger medium, and a cold loop and a warm loop contained in the heat exchanger medium. A control unit is configured for controlling cryogenic fuel supplied to the cold loop for cooling the thermal buffer heat exchanger. The thermal buffer heat exchanger enables precooling high pressure gaseous fuel to a preset temperature supplied to a dispenser supplying high pressure gaseous fuel to refuel a vehicle onboard storage tank system.
FILED Thursday, May 20, 2021
APPL NO 17/325819
CURRENT CPC
Vessels for Containing or Storing Compressed, Liquefied or Solidified Gases; Fixed-capacity Gas-holders; Filling Vessels With, or Discharging From Vessels, Compressed, Liquefied, or Solidified Gases
F17C 7/04 (20130101) Original (OR) Class
F17C 2221/012 (20130101)
F17C 2221/033 (20130101)
F17C 2223/0161 (20130101)
F17C 2225/0123 (20130101)
F17C 2227/0135 (20130101)
F17C 2227/0323 (20130101)
F17C 2227/0355 (20130101)
F17C 2250/032 (20130101)
F17C 2250/0636 (20130101)
F17C 2265/065 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220373229 MCKINION et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
APPLICANT(S) Helical Solar Solutions, LLC (Austin, Texas)
ASSIGNEE(S) Helical Solar Solutions, LLC (Austin, Texas)
INVENTOR(S) JAMES MCKINION (AUSTIN, Texas);  KEITH BECKER (CEDAR PARK, Texas)
ABSTRACT A load support system includes an elongate support member having a first diameter and a first end and a second end. The elongate support member includes, toward the first end, a first portion for direct earth burial and further includes, toward the second end, a second portion to which the load can be coupled. The first portion has a first length. The system additionally includes a lateral support having a second diameter greater than the first diameter and a second length less than the first length. The lateral support is mounted about the first portion of the elongate support member. The lateral support includes a first opening formed therein at a first location relative to a long axis of the elongate support member and a second opening formed therein at a different second location relative to the long axis in order to support a range of embedment depths.
FILED Tuesday, April 26, 2022
APPL NO 17/729879
CURRENT CPC
Solar Heat Collectors; Solar Heat Systems
F24S 25/12 (20180501) Original (OR) Class
F24S 25/617 (20180501)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220373397 Gopinath et al.
FUNDED BY
Department of Energy (DOE)
Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S) The Regents of the University of Colorado, a body corporate (Denver, Colorado)
ASSIGNEE(S)
INVENTOR(S) Juliet T. Gopinath (Boulder, Colorado);  Greg Krueper (Boulder, Colorado);  Lior Cohen (Denver, Colorado)
ABSTRACT An entanglement-enhanced interferometry system includes a source of correlated photons configured to two-mode squeezed vacuum (TMSV), a polarizing splitter or off-axis polarizing coupler configured to separate the correlated photons into two paths, a polarization control device configured to rotate polarization of photons on one of the two paths relative to the photons on the other of the two paths in order to make photons indistinguishable, a coupler configured to entangle the indistinguishable photons, and a polarization maintaining fiber-based interferometer configured to use the entangled photons as the input state. The source of correlated photons might be a nonlinear element such as a periodically poled element such as a lithium niobate bulk crystal or waveguide. The interferometer might be a Mach-Zehnder or a common path configuration. The coupler might be a 50:50 coupler or a polarizing coupler 45 degrees off-axis.
FILED Wednesday, May 11, 2022
APPL NO 17/742277
CURRENT CPC
Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry
G01J 9/02 (20130101) Original (OR) Class
G01J 2009/0226 (20130101)
G01J 2009/0261 (20130101)
G01J 2009/0288 (20130101)

Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters
G02F 1/365 (20130101)
G02F 1/395 (20130101)
G02F 1/3503 (20210101)
G02F 1/3536 (20130101)
G02F 1/3558 (20130101)
G02F 2202/20 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220373521 Van Berkel
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Oak Ridge National Laboratory (ORNL)
Federally Funded Research and Development Center (FFRDC)
Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S) UT-BATTELLE, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)
INVENTOR(S) Gary J. Van Berkel (Oak Ridge, Tennessee)
ABSTRACT A system for sampling a sample material includes a probe which can have an outer probe housing with an open end. A liquid supply conduit within the housing has an outlet positioned to deliver liquid to the open end of the housing. The liquid supply conduit can be connectable to a liquid supply for delivering liquid at a first volumetric flow rate to the open end of the housing. A liquid exhaust conduit within the housing is provided for removing liquid from the open end of the housing. A liquid exhaust system can be provided for removing liquid from the liquid exhaust conduit at a second volumetric flow rate. A droplet dispenser can dispense drops of a sample or a sample-containing solvent into the open end of the housing. A sensor and a processor can be provided to monitor and maintain a liquid dome present at the open end.
FILED Tuesday, April 26, 2022
APPL NO 17/729701
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/443 (20130101)
A61B 10/02 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 1/00 (20130101)
G01N 1/20 (20130101)
G01N 30/7233 (20130101) Original (OR) Class
G01N 35/1095 (20130101)
G01N 2030/027 (20130101)

Electric Discharge Tubes or Discharge Lamps
H01J 49/0404 (20130101)
H01J 49/0431 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220373555 Pallares et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Lawrence Berkeley National Laboratory (LBNL)
Federally Funded Research and Development Center (FFRDC)
Operated by University of California (UC BERKELEY) at Berkeley, CA
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S) Roger Molto Pallares (Berkeley, California);  Rebecca J. Abergel (Kensington, California)
ABSTRACT The present invention provides for a method to detect and/or quantify a gadolinium-based contrast agents (GBCA) in a sample, the method comprising: (a) providing a sample, (b) contacting the sample with a luminescent agent so that luminescent agent chelates a Gd3+ cation of the GBCA, and (c) measuring quenching of a luminescence emission within a range of wavelength; wherein the quenching of the luminescence emission corresponds to the amount of luminescent agent chelating a Gd3+ cation.
FILED Thursday, April 28, 2022
APPL NO 17/731313
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/76 (20130101)
G01N 21/6428 (20130101)
G01N 33/582 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220374036 Wang et al.
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S) RAYTHEON TECHNOLOGIES CORPORATION (Waltham, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Kaiyu Wang (Round Rock, Texas);  Vladimir Blasko (Avon, Connecticut);  William A. Veronesi (Hartford, Connecticut);  Moon C. Kim (Glastonbury, Connecticut);  Robert K. Thornton (Coventry, Connecticut)
ABSTRACT An energy storage assembly includes an energy storage unit. A supervisor is operable to determine a power reference set point based upon a cost function. A storage unit controller is configured to control the energy storage unit to provide electric energy to at least one load based upon a power reference input that is based upon the power reference set point and at least one dynamically changing power profile from the at least one load.
FILED Monday, May 02, 2022
APPL NO 17/734390
CURRENT CPC
Elevators; Escalators or Moving Walkways
B66B 1/24 (20130101)
B66B 1/302 (20130101)

Systems for Regulating Electric or Magnetic Variables
G05F 1/66 (20130101) Original (OR) Class

Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy
H02J 3/003 (20200101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220374515 Bridges et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Oak Ridge National Laboratory (ORNL)
Federally Funded Research and Development Center (FFRDC)
Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S) UT-Battelle, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)
INVENTOR(S) Robert A. Bridges (Oak Ridge, Tennessee);  Kiren E. Verma (Oak Ridge, Tennessee);  Michael Iannacone (Oak Ridge, Tennessee);  Samuel C. Hollifield (Oak Ridge, Tennessee);  Pablo Moriano (Oak Ridge, Tennessee);  Jordan Sosnowski (Oak Ridge, Tennessee)
ABSTRACT A system and method for intrusion detection on automotive controller area networks. The system and method can detect various CAN attacks, such as attacks that cause unintended acceleration, deactivation of vehicle's brakes, or steering the vehicle. The system and method detects changes in nuanced correlations of CAN timeseries signals and how they cluster together. The system reverse engineers CAN signals and detect masquerade attacks by analyzing timeseries extracted from raw CAN frames. Specifically, anomalies in the CAN data can be detected by computing timeseries clustering similarity using hierarchical clustering on the vehicle's CAN signals and comparing the clustering similarity across CAN captures with and without attacks.
FILED Thursday, April 21, 2022
APPL NO 17/725774
CURRENT CPC
Electric Digital Data Processing
G06F 21/552 (20130101)
G06F 21/554 (20130101)
G06F 21/556 (20130101) Original (OR) Class

Transmission of Digital Information, e.g Telegraphic Communication
H04L 12/40026 (20130101)
H04L 2012/40215 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220375684 Wolf
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Kansas City National Security Campus (KCNSC)
NNSA Critical Mission Site
Operated by Honeywell Federal Manufacturing and Technologies, LLC (FM&T) at Kansas City, MO
APPLICANT(S) Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri)
ASSIGNEE(S)
INVENTOR(S) Joseph Ambrose Wolf (Olathe, Kansas)
ABSTRACT Systems and methods of additively manufacturing passive electronic components are provided. An additive manufacturing device may deposit a material to create a passive electronic component. A sensor may continuously measure an electrical property of the passive electronic component across two electrical contacts as the material is deposited during manufacturing. The sensor may transmit the measured electrical property to a processor whereby the processor may adjust a material deposition rate of the additive manufacturing device. The continuous measurement of the electrical property and adjustment of the material deposition rate as the passive electronic component is produced allows for passive electronic components to be manufactured to a high degree of accuracy of the electrical property.
FILED Friday, March 18, 2022
APPL NO 17/698326
CURRENT CPC
Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder
B22F 10/85 (20210101)
B22F 12/90 (20210101)

Shaping Clay or Other Ceramic Compositions; Shaping Slag; Shaping Mixtures Containing Cementitious Material, e.g Plaster
B28B 1/001 (20130101)
B28B 17/0081 (20130101)

Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 64/393 (20170801)

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 10/00 (20141201)
B33Y 30/00 (20141201)
B33Y 50/02 (20141201)
B33Y 80/00 (20141201)

Resistors
H01C 17/065 (20130101)

Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties
H01F 41/043 (20130101) Original (OR) Class

Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type
H01G 4/33 (20130101)

Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components
H05K 1/162 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220375691 Chowdhury et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Oak Ridge National Laboratory (ORNL)
Federally Funded Research and Development Center (FFRDC)
Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S) UT-Battelle, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)
INVENTOR(S) Shajjad Chowdhury (Oak Ridge, Tennessee);  Raj Sahu (Mountain View, California);  Emre Gurpinar (Knoxville, Tennessee);  Burak Ozpineci (Oak Ridge, Tennessee)
ABSTRACT A capacitor packaging having a central termination and three or more capacitors (or groups of capacitors) arranged about the central termination. The electrical flow paths between the termination and the capacitors or groups of capacitors are of substantially the same length. The capacitors or groups of capacitors may be arranged in a generally circular pattern with the termination centered on the center. The termination may include first and second terminals. The capacitors may be mounted to a printed circuit board (“PCB”) with traces on opposite surfaces of the PCB providing electrical flow paths from the terminals to opposite legs of the capacitors. The capacitor packaging may include a primary PCB with a first circular arrangement of capacitors and a secondary PCB with a second circular arrangement of capacitors. The capacitors may be sandwiched between the PCBs with the second arrangement of capacitors disposed concentrically inwardly of the first arrangement.
FILED Thursday, May 12, 2022
APPL NO 17/742690
CURRENT CPC
Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type
H01G 4/38 (20130101) Original (OR) Class
H01G 4/232 (20130101)
H01G 4/1245 (20130101)

Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components
H05K 1/162 (20130101)
H05K 2201/09227 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220376190 Li et al.
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S) Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona)
ASSIGNEE(S)
INVENTOR(S) Jian Li (Tempe, Arizona);  Yunlong Ji (Mesa, Arizona)
ABSTRACT Metal-assisted delayed fluorescent emitters employing benzo-imidazo-phenanthridine and analogues for full color displays and lighting applications.
FILED Thursday, May 27, 2021
APPL NO 17/332100
CURRENT CPC
Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium
C07F 15/006 (20130101)
C07F 15/0033 (20130101)
C07F 15/0086 (20130101)

Materials for Miscellaneous Applications, Not Provided for Elsewhere
C09K 11/06 (20130101)
C09K 2211/1074 (20130101)

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 51/0084 (20130101) Original (OR) Class
H01L 51/0085 (20130101)
H01L 51/0087 (20130101)
H01L 51/5016 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220376223 YADAV et al.
FUNDED BY
Department of Energy (DOE)
Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S) RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK (New York, New York)
ASSIGNEE(S)
INVENTOR(S) Gautam G. YADAV (New York, New York);  Xia WEI (New York, New York);  Michael NYCE (New York, New York);  Sanjoy BANERJEE (New York, New York)
ABSTRACT A system and method for forming a metallic ion intercalated layered structure can include a housing, an electrolyte disposed in the housing, a counter-electrode disposed in the housing, and a working electrode disposed in the housing. The working electrode comprises a metallic support; and an electrode paste. The electrode paste can include an active material and a binder. The system can be used to form a layered structure having metallic ions from the metallic support intercalated into the layered structure based on cycling the working electrode.
FILED Friday, October 30, 2020
APPL NO 17/772578
CURRENT CPC
Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/50 (20130101)
H01M 4/52 (20130101)
H01M 4/0445 (20130101)
H01M 4/0459 (20130101) Original (OR) Class
H01M 4/661 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220376232 KUMTA
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S) UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania)
ASSIGNEE(S) UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania)
INVENTOR(S) Prashant N. KUMTA (Pittsburgh, Pennsylvania)
ABSTRACT The inventive concepts include at least an electrode architecture including a composite structure that includes engineered carbon nanofibers, a lithium-impervious elastic polymer, a copper collector and a lithium-containing cathode; dendrite-free, lithium metal-plated anode that includes the electrode architecture; and a lithium metal-based lithium ion battery that includes the lithium metal-plated anode, liquid and solid electrolytes and a lithium-free cathode.
FILED Wednesday, November 04, 2020
APPL NO 17/773725
CURRENT CPC
Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/366 (20130101) Original (OR) Class
H01M 4/0471 (20130101)
H01M 4/625 (20130101)
H01M 4/661 (20130101)
H01M 10/0525 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220376240 Luo et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Oak Ridge National Laboratory (ORNL)
Federally Funded Research and Development Center (FFRDC)
Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S) UT-Battelle, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)
INVENTOR(S) Huimin Luo (Knoxville, Tennessee);  Sheng Dai (Knoxville, Tennessee);  Tao Wang (Knoxville, Tennessee);  Ilias Belharouak (Knoxville, Tennessee);  Jianlin Li (Knoxville, Tennessee);  Yaocai Bai (Knoxville, Tennessee)
ABSTRACT A method for relithiating cathode material from spent lithium-based batteries, the method comprising: (i) mixing delithiated cathode material and a lithium salt with an ionic liquid in which the lithium salt is at least partially soluble to form an initial mixture; (ii) heating the initial mixture to a temperature of 100° C. to 300° C. to result in relithiation of the delithiated cathode material; and (iii) separating the ionic liquid from the relithiated cathode material; wherein, in embodiments, the cathode material is a lithium metal oxide, wherein the metal is selected from the group consisting of Ni, Co, Fe, Mn, Al, Zr, Ti, Nb, and combinations thereof, or wherein the cathode material has the formula LiNixMnyCozO2, wherein x>0, y>0, z>0, and x+y+z=1; wherein, in some embodiments, the ionic liquid has a nitrogen-containing cationic portion, such as an imidazolium ionic liquid.
FILED Wednesday, May 04, 2022
APPL NO 17/736426
CURRENT CPC
Compounds Containing Metals Not Covered by Subclasses C01D or C01F
C01G 53/50 (20130101)

Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/04 (20130101)
H01M 4/505 (20130101)
H01M 4/525 (20130101) Original (OR) Class
H01M 2004/028 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220376246 Anderson et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
APPLICANT(S) The University of Chicago (Chicago, Illinois)
ASSIGNEE(S)
INVENTOR(S) John S. Anderson (Chicago, Illinois);  Noah E. Horwitz (Chicago, Illinois);  Jiaze Xie (Chicago, Illinois)
ABSTRACT A lamellar transition metal sulfide composition having layers of an amorphous transition metal sulfide with cations interspersed between the layers is described. Also described are methods of synthesizing the lamellar transition metal sulfides and the use of the lamellar transition metal sulfides in electrodes, e.g., in metal-ion batteries, metal-ion/sulfur batteries, and capacitors.
FILED Tuesday, September 29, 2020
APPL NO 17/765176
CURRENT CPC
Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type
H01G 9/042 (20130101)

Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/58 (20130101) Original (OR) Class
H01M 4/136 (20130101)
H01M 4/366 (20130101)
H01M 4/622 (20130101)
H01M 4/623 (20130101)
H01M 4/663 (20130101)
H01M 10/0525 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220376312 CHEN et al.
FUNDED BY
Department of Energy (DOE)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Zheng CHEN (San Diego, California);  Yang SHI (San Diego, California);  Panpan XU (San Diego, California)
ABSTRACT Regeneration of degraded cathode particles in lithium-ion batteries is achieved using a combination of hydrothermal treatment of cycled electrode particles followed by short thermal annealing. The methods provide for direct regeneration of Li-ion cathode materials including LiCoO2, LiMn2O4, LiFePO4, and LixNiy Mnz Co1−y−zO2, in an economical and environmentally-friendly process.
FILED Thursday, March 17, 2022
APPL NO 17/697889
CURRENT CPC
Compounds of Alkali Metals, i.e Lithium, Sodium, Potassium, Rubidium, Caesium, or Francium
C01D 15/08 (20130101)

Compounds Containing Metals Not Covered by Subclasses C01D or C01F
C01G 45/1228 (20130101)

Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/505 (20130101)
H01M 4/525 (20130101)
H01M 4/5825 (20130101)
H01M 10/0525 (20130101)
H01M 10/4242 (20130101) Original (OR) Class
H01M 2004/028 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220376453 Edwards et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Lawrence Livermore National Laboratory (LLNL)
Federally Funded Research and Development Center (FFRDC)
Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S) Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S)
INVENTOR(S) Matthew Reid Edwards (Livermore, California);  Pierre Michel (Oakland, California)
ABSTRACT A diffractive optical element, such as a plasma grating, can be made by directing two laser beams so that they overlap in a nonlinear material to form an interference pattern in the nonlinear material. The interference pattern can modify the index of refraction in the nonlinear material to produce the diffractive optical element. A chirped pulse amplification system can stretch, amplify, and then compress a laser pulse, and the plasma grating can be used to compress the laser pulse since the plasma optic can withstand the high light intensity of the compressed pulse.
FILED Monday, May 09, 2022
APPL NO 17/740105
CURRENT CPC
Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical
H01S 3/0057 (20130101) Original (OR) Class
H01S 3/2308 (20130101)
H01S 3/08009 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220377845 Baset et al.
FUNDED BY
Department of Energy (DOE)
Office of Nuclear Energy (DOE-NE)
Idaho National Laboratory (INL)
Federally Funded Research and Development Center (FFRDC)
Operated by Battelle Energy Alliance, LLC (BEA) at Idaho Falls, ID
APPLICANT(S) Battelle Energy Alliance, LLC (Idaho Falls, Idaho);  University of Utah Research Foundation (Salt Lake City, Utah)
ASSIGNEE(S)
INVENTOR(S) Aniqua Z. Baset (Salt Lake City, Utah);  Christopher D. Becker (Aitkin, Minnesota);  Samuel Ramirez (Shelley, Idaho);  Sneha K. Kasera (Salt Lake City, Utah);  Kurt W. Derr (Idaho Falls, Idaho)
ABSTRACT Processing flows and related systems and methods are disclosed. A computing system includes one or more data interfaces, one or more other components, and a controller. The one or more data interfaces are configured to provide an interface to a data source. The one or more other components include one or more controller plugins, one or more processing nodes, or both the one or more controller plugins and the one or more processing nodes. The controller is configured to manage interactions between the one or more data interfaces and the one or more other components and enable a user to chain together the one or more data interfaces and the one or more other components according to one or more flows. The one or more controller plugins are configured to provide results of the one or more flows to one of a user interface and a system interface.
FILED Friday, October 30, 2020
APPL NO 17/755299
CURRENT CPC
Wireless Communication Networks
H04W 24/08 (20130101)
H04W 24/10 (20130101)
H04W 88/12 (20130101) Original (OR) Class
H04W 88/085 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220377882 Diamond
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Kansas City National Security Campus (KCNSC)
NNSA Critical Mission Site
Operated by Honeywell Federal Manufacturing and Technologies, LLC (FM&T) at Kansas City, MO
APPLICANT(S) Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri)
ASSIGNEE(S) Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri)
INVENTOR(S) Louis Diamond (Kansas City, Missouri)
ABSTRACT A blank package for mimicking an electronic component package comprises a body and a plurality of conductive pads. The body is formed from generally transparent electrically insulating material and has a top surface, a bottom surface, and a plurality of side surfaces. The bottom surface has a shape and dimensions that are similar to a bottom surface of the electronic component package. The conductive pads are formed from electrically conductive material and attached to the body, with each conductive pad corresponding to a successive one of the conductive pads of the electronic component package. Each conductive pad has features that are similar to features of the corresponding conductive pad of the electronic component package.
FILED Wednesday, July 06, 2022
APPL NO 17/858336
CURRENT CPC
Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components
H05K 1/09 (20130101)
H05K 1/111 (20130101)
H05K 1/0274 (20130101) Original (OR) Class
H05K 1/0306 (20130101)
H05K 2201/0108 (20130101)
H05K 2201/0338 (20130101)
H05K 2201/0344 (20130101)
H05K 2201/09418 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220377888 Diamond
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Kansas City National Security Campus (KCNSC)
NNSA Critical Mission Site
Operated by Honeywell Federal Manufacturing and Technologies, LLC (FM&T) at Kansas City, MO
APPLICANT(S) Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri)
ASSIGNEE(S) Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri)
INVENTOR(S) Louis Diamond (Kansas City, Missouri)
ABSTRACT A blank package for mimicking an electronic component package comprises a body and a plurality of conductive pads. The body is formed from generally transparent electrically insulating material and has a top surface, a bottom surface, and a plurality of side surfaces. The bottom surface has a shape and dimensions that are similar to a bottom surface of the electronic component package. The conductive pads are formed from electrically conductive material and attached to the body, with each conductive pad corresponding to a successive one of the conductive pads of the electronic component package. Each conductive pad has features that are similar to features of the corresponding conductive pad of the electronic component package.
FILED Thursday, January 20, 2022
APPL NO 17/579974
CURRENT CPC
Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components
H05K 1/09 (20130101)
H05K 1/11 (20130101) Original (OR) Class
H05K 1/0274 (20130101)
H05K 1/0306 (20130101)
H05K 2201/0108 (20130101)
H05K 2201/0338 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

National Science Foundation (NSF) 

US 20220370641 Delcamp et al.
FUNDED BY
National Science Foundation (NSF)
Office of The Director (OD)
Office of Integrative Activities (OIA)
APPLICANT(S) UNIVERSITY OF MISSISSIPPI (Oxford, Mississippi)
ASSIGNEE(S)
INVENTOR(S) Jared Heath Delcamp (Oxford, Mississippi);  David Ndaleh Dodah Nghombui (Oxford, Mississippi);  William Edward Meador (Oxford, Mississippi)
ABSTRACT Described herein are new silicone-based compounds that have short wavelength infrared (SWIR) absorption and emission. The silicone-based compounds are readily accessible and obtainable on large scale with high purity through simple purification procedures. In one aspect, the silicone-based compounds have an absorption extending into the SWIR region and an emission maximum in the SWIR region which is promising for biological imaging applications.
FILED Monday, May 09, 2022
APPL NO 17/662574
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 49/0021 (20130101) Original (OR) Class

Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes
C09B 57/00 (20130101)

Materials for Miscellaneous Applications, Not Provided for Elsewhere
C09K 11/06 (20130101)
C09K 2211/1007 (20130101)
C09K 2211/1018 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370643 Yap et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
Directorate of Technology, Innovation and Partnerships (TIP)
Translational Impacts (TI)
APPLICANT(S) Michigan Technological University (Houghton, Michigan)
ASSIGNEE(S)
INVENTOR(S) Yoke Khin Yap (Houghton, Michigan);  Dongyan Zhang (Houghton, Michigan);  Nazmiye Yapici (South Lyon, Michigan);  Xiuling Liu (Ann Arbor, Michigan)
ABSTRACT A compound includes a first linker having a first end connected to the carrier, a second linker having a first end connected to the carrier, a third linker having a first end connected to the carrier, a first fluorescent entity connected to a second end of the first linker, a second fluorescent entity different from the first fluorescent entity connected to a second end of the second linker, and a biomolecule connected to a second end of the third linker. The biomolecule is configured to connect to a biomarker. A method of detecting biomarkers is also disclosed.
FILED Wednesday, September 30, 2020
APPL NO 17/765310
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 49/0054 (20130101) Original (OR) Class

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 30/00 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/533 (20130101)
G01N 33/54353 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370679 Vatankhan-Varnosfaderani et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (Chapel Hill, North Carolina)
ASSIGNEE(S)
INVENTOR(S) Mohammad Vatankhan-Varnosfaderani (San Diego, California);  Sergei Sheiko (Chapel Hill, North Carolina);  Erfan Dashtimoghadam (Chapel Hill, North Carolina)
ABSTRACT Materials and methods related to elastomers are disclosed. The disclosed elastomers are useful in implants mimicking soft tissue. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
FILED Friday, October 02, 2020
APPL NO 17/765546
CURRENT CPC
Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 24/06 (20130101) Original (OR) Class
A61L 24/046 (20130101)
A61L 27/16 (20130101)
A61L 27/18 (20130101)
A61L 2400/06 (20130101)

Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor
A61M 5/19 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370687 Lee et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
NIH Office of the Director (NIHOD)
National Institute of Neurological Disorders and Stroke (NINDS)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) Rutgers, The State University of New Jersey (New Brunswick, New Jersey)
ASSIGNEE(S) Rutgers, The State University of New Jersey (New Brunswick, New Jersey)
INVENTOR(S) Ki-Bum Lee (Monmouth Junction, New Jersey);  Letao Yang (Piscataway, New Jersey)
ABSTRACT A three dimensional scaffold for generating cell or protein assemblies. This degradable scaffold can be applied to various types of cells. Also disclosed are methods of treating a condition by implanting the protein or cell assembly prepared according to the method described herein.
FILED Tuesday, May 24, 2022
APPL NO 17/664792
CURRENT CPC
Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 27/14 (20130101)
A61L 27/025 (20130101)
A61L 27/56 (20130101) Original (OR) Class
A61L 2400/12 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220371056 Horowitz et al.
FUNDED BY
National Science Foundation (NSF)
Directorate of Technology, Innovation and Partnerships (TIP)
Translational Impacts (TI)
APPLICANT(S) AMP Robotics Corporation (Louisville, Colorado)
ASSIGNEE(S)
INVENTOR(S) Matanya B. Horowitz (Golden, Colorado);  James A. Bailey (Boulder, Colorado);  John C. McCoy, JR. (Thornton, Colorado)
ABSTRACT Systems and methods for sorting recyclable items and other materials are provided. In one embodiment, a system for sorting objects comprises: at least one imaging sensor; a controller comprising a processor and memory storage, wherein the controller receives image data captured by the image sensor; and at least one pusher device coupled to the controller, wherein the at least one pusher device is configured to receive an actuation signal from the controller. The processor is configured to detect objects travelling on a conveyor device and recognize at least one target item traveling on a conveyor device by processing the image data and to determine an expected time when the at least one target item will be located within a diversion path of the pusher device. The controller selectively generates the actuation signal based on whether a sensed object detected in the image data comprise the at least one target item.
FILED Monday, June 20, 2022
APPL NO 17/844591
CURRENT CPC
Postal Sorting; Sorting Individual Articles, or Bulk Material Fit to be Sorted Piece-meal, e.g by Picking
B07C 1/04 (20130101)
B07C 5/36 (20130101)
B07C 5/367 (20130101)
B07C 5/368 (20130101)
B07C 5/3422 (20130101) Original (OR) Class
B07C 2501/0054 (20130101)

Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements
G05B 13/027 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220371181 Ben-Tzvi et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S) VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (Blacksburg, Virginia)
ASSIGNEE(S)
INVENTOR(S) Pinhas Ben-Tzvi (Blacksburg, Virginia);  Vinaykarthik Kamidi (Blacksburg, Virginia)
ABSTRACT The present invention concerns a novel leg mechanism for quadrupedal locomotion. This design engages a linkage to couple assembly that only requires a single degree of actuation. The topological arrangement of the system produces a foot trajectory that is well-suited for dynamic gaits including trot-running, bounding, and galloping.
FILED Wednesday, July 20, 2022
APPL NO 17/813772
CURRENT CPC
Manipulators; Chambers Provided With Manipulation Devices
B25J 9/1065 (20130101) Original (OR) Class
B25J 9/1664 (20130101)
B25J 17/00 (20130101)
B25J 19/0091 (20130101)

Motor Vehicles; Trailers
B62D 57/032 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220371188 Bhatia et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) Carnegie Mellon University (Pittsburgh, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Ankit Bhatia (Pittsburgh, Pennsylvania);  Aaron Johnson (Pittsburgh, Pennsylvania);  Matthew T. Mason (Pittsburgh, Pennsylvania)
ABSTRACT A gripper includes at least one movable finger. Each movable finger includes a first motor, a second motor, a first motor link having a first end coupled to a rotor of the first motor, a second motor link having a first end coupled to a rotor of the second motor, a finger link having a first end in pivotal connection with a second end of the second motor link and a gripper pad, and a connecting link having a first end in pivotal connection with a second end of the first motor link and a second end in pivotal connection with the finger link. The gripper further includes at least one controller programmed or configured to actuate the first motor and the second motor of each of the at least one movable finger.
FILED Friday, May 21, 2021
APPL NO 17/326719
CURRENT CPC
Manipulators; Chambers Provided With Manipulation Devices
B25J 9/12 (20130101)
B25J 9/1612 (20130101) Original (OR) Class
B25J 9/1633 (20130101)
B25J 13/088 (20130101)
B25J 15/0009 (20130101)
B25J 15/0028 (20130101)

Control or Regulation of Electric Motors, Electric Generators or Dynamo-electric Converters; Controlling Transformers, Reactors or Choke Coils
H02P 29/64 (20160201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220371193 CHU et al.
FUNDED BY
National Science Foundation (NSF)
Directorate of Technology, Innovation and Partnerships (TIP)
Translational Impacts (TI)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Diligent Robotics, Inc. (Austin, Texas)
ASSIGNEE(S)
INVENTOR(S) Vivian Yaw-Wen CHU (Austin, Texas);  Shuai LI (Sammamish, Washington);  Forrest GREEN (Austin, Texas);  Peter WORSNOP (Bethesda, Maryland);  Andrea Lockerd THOMAZ (Austin, Texas)
ABSTRACT Systems, apparatus, and methods are described for robotic learning and execution of skills. A robotic apparatus can include a memory, a processor, sensors, and one or more movable components (e.g., a manipulating element and/or a transport element). The processor can be operatively coupled to the memory, the movable elements, and the sensors, and configured to obtain information of an environment, including one or more objects located within the environment. In some embodiments, the processor can be configured to learn skills through demonstration, exploration, user inputs, etc. In some embodiments, the processor can be configured to execute skills and/or arbitrate between different behaviors and/or actions. In some embodiments, the processor can be configured to learn an environmental constraint. In some embodiments, the processor can be configured to learn using a general model of a skill.
FILED Wednesday, March 09, 2022
APPL NO 17/690197
CURRENT CPC
Manipulators; Chambers Provided With Manipulation Devices
B25J 5/00 (20130101)
B25J 9/06 (20130101)
B25J 9/0081 (20130101)
B25J 9/163 (20130101)
B25J 9/1661 (20130101) Original (OR) Class
B25J 9/1694 (20130101)
B25J 11/0005 (20130101)
B25J 15/00 (20130101)
B25J 19/02 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220371219 YADAMA et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) Washington State University (Pullman, Washington);  UNIVERSITY OF MINNESOTA DULUTH (Duluth, Minnesota)
ASSIGNEE(S)
INVENTOR(S) Vikram YADAMA (Pullman, Washington);  Ruben A. JERVES (Pullman, Washington);  Matthew ARO (Duluth, Minnesota)
ABSTRACT Improved wood strand panels suitable for construction are produced by first thermally modifying a plurality of wood strands that are thin in terms of thickness. Then, wood veneers are constructed from the thermally modified wood strands, at least some of which partially overlap one another. The wood veneers are on the order of 0.125 to 0.25 inches thick. Finally, the wood veneers, constructed from the thermally modified wood strands, are stacked on top of one another and connected using adhesive, pressure and temperature similar to plywood or LVL manufacture. The thermal modification and use of thin strands, followed by veneer formation, prior to manufacture of the composite results in a composite with uniform density, high-strength, resistance to decay, resistance to water sorption, and other benefits.
FILED Monday, May 16, 2022
APPL NO 17/745174
CURRENT CPC
Working Veneer or Plywood
B27D 1/04 (20130101) Original (OR) Class

Manufacture by Dry Processes of Articles, With or Without Organic Binding Agents, Made From Particles or Fibres Consisting of Wood or Other Lignocellulosic or Like Organic Material
B27N 1/00 (20130101)
B27N 3/04 (20130101)

Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form
B32B 21/13 (20130101)
B32B 21/14 (20130101)
B32B 37/12 (20130101)
B32B 2260/026 (20130101)
B32B 2309/12 (20130101)
B32B 2309/025 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220371266 Huang et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S) CORNELL UNIVERSITY (Ithaca, New York)
ASSIGNEE(S)
INVENTOR(S) Jen-Yu Huang (Ithaca, New York);  Tangi Aubert (Ithaca, New York);  Tobias Hanrath (Ithaca, New York);  Ulrich B. Wiesner (Ithaca, New York)
ABSTRACT Provided are compositions that may be referred to as photoreactive compositions or inks. The compositions may have a plurality of reactive components, which are silica nanocages with one or more photoreactive ligand(s). Also provided are methods of making an article of manufacture. Also provided are articles of manufacture and uses thereof. The article of manufacture may be formed from a composition of the present disclosure.
FILED Monday, November 02, 2020
APPL NO 17/772178
CURRENT CPC
Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 64/153 (20170801) Original (OR) Class

Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts
B29K 2509/00 (20130101)

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 10/00 (20141201)
B33Y 70/00 (20141201)
B33Y 80/00 (20141201)

Non-metallic Elements; Compounds Thereof;
C01B 33/12 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220371272 Pearlson
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) Igneous IP Holdings, LLC (Wales, Wisconsin)
ASSIGNEE(S)
INVENTOR(S) Matthew N. Pearlson (Wales, Wisconsin)
ABSTRACT An additive manufacturing technique uses digital mask-based illumination and a polar-based build environment for increased throughput. In one embodiment, the build environment comprises a rotating element having a surface. A coater is configured to deposit photopolymer material on the rotating element at a given flow rate. As the element rotates and the coater deposits the photopolymer material, a radiation source of an image scanning system projects an array of point sources (an image) onto the photopolymer material for an exposure time to cure a given layer. As the photopolymer material is deposited layer-upon-layer, and for each layer, a control system adjusts a relative position of the coater with respect to the surface, adjusts a speed of rotation of the rotating element, and maintains the flow rate and the exposure time constant.
FILED Friday, May 20, 2022
APPL NO 17/749315
CURRENT CPC
Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 64/124 (20170801)
B29C 64/245 (20170801) Original (OR) Class
B29C 64/277 (20170801)

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 10/00 (20141201)
B33Y 30/00 (20141201)
B33Y 40/20 (20200101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220371284 Feng et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S) NEW YORK UNIVERSITY (New York, New York)
ASSIGNEE(S)
INVENTOR(S) Chen Feng (New York, New York);  Xuchu Xu (Brooklyn, New York)
ABSTRACT A display guided robotic navigation and control system comprises a display system including a display surface and a display device configured to display an image including a visual pattern onto the display surface, a robotic system including a mobile robotic device and an optical sensor attached to the mobile robotic device, and a computing system communicatively connected to the display system and the robotic system. Related methods are also disclosed.
FILED Friday, May 06, 2022
APPL NO 17/738164
CURRENT CPC
Manipulators; Chambers Provided With Manipulation Devices
B25J 9/163 (20130101)
B25J 9/1607 (20130101)
B25J 9/1664 (20130101)
B25J 9/1692 (20130101)
B25J 9/1697 (20130101)

Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 64/209 (20170801)
B29C 64/227 (20170801)
B29C 64/393 (20170801) Original (OR) Class

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 30/00 (20141201)
B33Y 50/02 (20141201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220371547 SHIN et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computer and Network Systems (CNS)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan);  THE UNIVERSITY OF COLORADO (Denver, Colorado)
ASSIGNEE(S) THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan);  THE UNIVERSITY OF COLORADO (Denver, Colorado)
INVENTOR(S) Kang G. SHIN (Ann Arbor, Michigan);  Liang HE (Denver, Colorado)
ABSTRACT A driving authentication system is presented for a vehicle. The system includes: a dongle interfaced with a battery of the vehicle and an authenticator configured to receive a discharge current from the battery. The dongle operates to modulate discharge current from the battery with an input code; and the authenticator demodulate the input code from the discharge current, compares the input code to the one or more known authentication codes and, in response to the input code matching one of the one or more known authentication codes, controls power capacity of the battery.
FILED Thursday, March 24, 2022
APPL NO 17/703346
CURRENT CPC
Vehicles, Vehicle Fittings, or Vehicle Parts, Not Otherwise Provided for
B60R 25/04 (20130101)
B60R 25/23 (20130101) Original (OR) Class
B60R 25/1001 (20130101)

Starting of Combustion Engines; Starting Aids for Such Engines, Not Otherwise Provided for
F02N 11/087 (20130101)
F02N 11/0862 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372009 WEBSTER et al.
FUNDED BY
National Science Foundation (NSF)
Office of The Director (OD)
Office of Integrative Activities (OIA)
APPLICANT(S) NDSU RSEARCH FOUNDATION (Fargo, North Dakota)
ASSIGNEE(S)
INVENTOR(S) Dean C. WEBSTER (Fargo, North Dakota);  Mukund P. SIBI (Fargo, North Dakota);  Catherine A. SUTTON (Fargo, North Dakota);  Deep J. KALITA (Fargo, North Dakota);  Eric M. SERUM (Eau Claire, Wisconsin)
ABSTRACT The invention relates to diols derived from 5-hydroxymethyl furfural, diformyl furan, or derivatives thereof. The invention further relates to diglycidyl ethers derived from the diols of the invention, curable coating compositions containing the diglycidyl ethers, and objects coated with the curable coating compositions. The invention also relates to composites, composites, adhesives, and films containing the diglycidyl ethers of the invention. The invention also relates to methods of making the diols, diglycidyl ethers, and curable coating compositions.
FILED Monday, July 06, 2020
APPL NO 17/623405
CURRENT CPC
Heterocyclic Compounds
C07D 307/42 (20130101) Original (OR) Class
C07D 407/14 (20130101)

Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor
C09D 163/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372116 Lai et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina)
ASSIGNEE(S)
INVENTOR(S) Samuel Lai (Carrboro, North Carolina);  M. Gregory Forest (Chapel Hill, North Carolina);  Christine Henry (Chapel Hill, North Carolina);  Timothy Wessler (Durham, North Carolina);  Alexander Chen (Glenville, New York);  Jennifer Schiller (Chapel Hill, North Carolina);  Jay Newby (Carrboro, North Carolina)
ABSTRACT The presently-disclosed subject matter relates to crosslinkers, compositions, and methods for trapping a target of interest on a substrate of interest. The methods may be used to inhibit and treat pathogen infection and provide contraception. The methods may be used to trap or separate particles and other substances. The subject matter further relates to methods of identifying and preparing optimal crosslinkers and methods for manipulating targets of interest.
FILED Friday, March 18, 2022
APPL NO 17/698645
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/00 (20180101)

Peptides
C07K 16/44 (20130101)
C07K 16/087 (20130101)
C07K 16/1045 (20130101)
C07K 16/1235 (20130101) Original (OR) Class

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/557 (20130101)
G01N 33/6854 (20130101)
G01N 33/54346 (20130101)
G01N 33/56983 (20130101)
G01N 2333/16 (20130101)
G01N 2333/4725 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372200 GIANNESCHI et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) Northwestern University (Evanston, Illinois)
ASSIGNEE(S) Northwestern University (Evanston, Illinois)
INVENTOR(S) Nathan C. GIANNESCHI (Evanston, Illinois);  Hao SUN (Evanston, Illinois)
ABSTRACT Aspects of the invention include a method for synthesizing a peptide brush polymer, the method comprising: exposing a mixture comprising peptide-containing monomers, one or more photoinitiators, and one or more chain transfer agents to a light sufficient to induce photopolymerization, and photopolymerizing the peptide-containing monomers in the mixture; wherein: the resulting peptide brush polymer comprises at least one peptide-containing polymer block; the at least one peptide-containing polymer block is characterized by a degree of polymerization of at least 10 and a peptide graft density of 50% to 100%; and at least one peptide moiety of the at least one peptide-containing polymer block has 5 or more amino acid groups.
FILED Tuesday, September 29, 2020
APPL NO 17/764746
CURRENT CPC
Peptides
C07K 1/1077 (20130101)

Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds
C08F 2/10 (20130101)
C08F 2/50 (20130101)
C08F 299/022 (20130101) Original (OR) Class
C08F 2438/03 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372234 GAO et al.
FUNDED BY
National Science Foundation (NSF)
Directorate of Technology, Innovation and Partnerships (TIP)
Translational Impacts (TI)
APPLICANT(S) ARYTHA BIOSCIENCES, LLC (San Diego, California)
ASSIGNEE(S) ARYTHA BIOSCIENCES, LLC (San Diego, California)
INVENTOR(S) Weiwei GAO (La Jolla, California);  Che-Ming Jack HU (Taipei City, Taiwan)
ABSTRACT The present invention relates to processes and systems for preparing nanoparticles, cellular or viral membranes and/or cellular or viral membrane coated nanoparticles using or comprising, inter alia, a multi-inlet vortexing reactor, tangential flow filtration (TFF) and/or a high shear fluid processor such as a microfluidizer (or a microfluidizer processor). The present invention also relates to the nanoparticles, cellular or viral membranes and/or cellular or viral membrane coated nanoparticles prepared by the present processes and systems, and the uses and/or applications of the nanoparticles, cellular or viral membranes and/or cellular or viral membrane coated nanoparticles.
FILED Monday, May 23, 2022
APPL NO 17/751052
CURRENT CPC
Separation
B01D 61/146 (20220801)
B01D 63/02 (20130101)

Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H
C08J 3/12 (20130101) Original (OR) Class

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0006 (20130101)
C12N 5/0087 (20130101)
C12N 5/0641 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372272 ZHAO et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S) OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio);  GEORGIA TECH RESEARCH CORPORATION (Atlanta, Georgia)
ASSIGNEE(S)
INVENTOR(S) Ruike ZHAO (Columbus, Ohio);  Xiao KUANG (Atlanta, Georgia);  Hang QI (Atlanta, Georgia);  Qiji ZE (Columbus, Ohio);  Shuai WU (Columbus, Ohio)
ABSTRACT Disclosed magnetic shape-memory compositions that comprise a polymer matrix and a population of hard-magnetic particles dispersed within the polymer matrix. In some embodiments, the magnetic shape-memory compositions can further comprise a population of auxiliary magnetic particles (e.g., ferrite particles) dispersed within the polymer matrix. The compositions can exhibit 1) reversible, fast, and controllable transforming deformation, 2) shape-locking, and 3) reprogramming capabilities.
FILED Friday, June 19, 2020
APPL NO 17/621150
CURRENT CPC
Compositions of Macromolecular Compounds
C08L 63/00 (20130101) Original (OR) Class
C08L 2201/12 (20130101)
C08L 2203/02 (20130101)
C08L 2207/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372441 Papoutsakis et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) Eleftherios Papoutsakis (Newark, Delaware);  Chen-Yuan Kao (Newark, Delaware);  Jinlin Jiang (Rockville, Maryland)
ASSIGNEE(S) University of Delaware (Newark, Delaware)
INVENTOR(S) Eleftherios Papoutsakis (Newark, Delaware);  Chen-Yuan Kao (Newark, Delaware);  Jinlin Jiang (Rockville, Maryland)
ABSTRACT The present invention relates to a method for inducing megakaryocytic differentiation of hematopoietic stem/progenitor cells (HSPCs). The method comprises transferring into the HSPCs an effective amount of small RNAs. The HSPCs may differentiate into megakaryocytes in the absence of thrombopoietin (TPO) and/or without using megakaryocytic microparticles (MkMPs). The small RNAs may be micro RNAs (miRs) selected from the group consisting of miR-486, miR-22, miR-191, miR-181, miR-378, miR-26, let-7, miR-92, miR-126, miR-92, miR-21, miR-146, miR-181, and combinations thereof. For example, the small RNAs are miR-486 and miR-22. The small RNAs may be synthetic or isolated from cells. Also provided is a method for enhancing megakaryocytic differentiation of HSPCs cultured with megakaryocytic microparticles MkMPs in the presence of an effective amount of one or more exogenous small RNAs (e.g., miR-486).
FILED Wednesday, October 21, 2020
APPL NO 17/770433
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0644 (20130101) Original (OR) Class
C12N 15/113 (20130101)
C12N 2310/141 (20130101)
C12N 2501/65 (20130101)
C12N 2506/11 (20130101)
C12N 2527/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372451 Eiteman et al.
FUNDED BY
National Science Foundation (NSF)
Department of Agriculture (USDA)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) University of Georgia Research Foundation, Inc. (Athens, Georgia)
ASSIGNEE(S)
INVENTOR(S) Mark Andrew Eiteman (Athens, Georgia);  William Chris Moxley (Athens, Georgia)
ABSTRACT Modified bacterial strains are provided. The strains can generate a desired product such as pyruvate and products derived from pyruvate. Methods of generating pyruvate and products derived from pyruvate are also provided. The modified bacterial strains have at least one mutation in a gene coding for proteins in a pyruvate dehydrogenase complex such that the mutation allows a cell to accumulate pyruvate and/or products derived from pyruvate.
FILED Tuesday, April 26, 2022
APPL NO 17/729120
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/0008 (20130101) Original (OR) Class

Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture
C12P 7/24 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372467 Chatterjee et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) TRUSTEES OF BOSTON COLLEGE (Chestnut Hill, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Abhishek Chatterjee (Lexington, Massachusetts);  Rachel E. Kelemen (Newton, Massachusetts);  Delilah Jewel (Chestnut Hill, Massachusetts)
ABSTRACT The present invention involves the ability to 1) use a virus assisted directed evolution platform to significantly improve the activity of engineered nonsense-suppressor tRNAs in mammalian cells, 2) provide mutants of archaeal pyrrolysyl and E. coli leucyl tRNAs that show remarkably improved Uaa incorporation efficiency in mammalian cells, and 3) use these tRNAs to express recombinant proteins in mammalian cells incorporating Uaas at significantly improved yields.
FILED Friday, June 19, 2020
APPL NO 17/620887
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/67 (20130101)
C12N 15/86 (20130101)
C12N 15/1058 (20130101) Original (OR) Class
C12N 2750/14122 (20130101)
C12N 2750/14143 (20130101)

Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture
C12P 21/02 (20130101)

Enzymes
C12Y 601/01026 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372526 Hamberger et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
National Science Foundation (NSF)
Directorate for Biological Sciences (BIO)
Division of Environmental Biology (DEB)
APPLICANT(S) Board of Trustees of Michigan State University (East Lansing, Michigan)
ASSIGNEE(S)
INVENTOR(S) Björn Hamberger (Okemos, Michigan);  Sean Johnson (Bedford, Massachusetts);  Wajid Waheed Bhat (Srinagar, J&K, India)
ABSTRACT Enzymes and methods are described herein for manufacturing terpenes, including terpenes.
FILED Friday, August 02, 2019
APPL NO 17/265482
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/1022 (20130101)
C12N 9/1085 (20130101)
C12N 15/8243 (20130101)

Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture
C12P 5/002 (20130101) Original (OR) Class
C12P 17/02 (20130101)
C12P 17/06 (20130101)

Enzymes
C12Y 202/01007 (20130101)
C12Y 205/01029 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372553 Madrid et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
National Science Foundation (NSF)
Directorate for Education and Human Resources (EHR)
Division of Human Resource Development (HRD)
APPLICANT(S) Andy Madrid (Madison, Wisconsin);  Reid Spencer Alisch (Prairie du Sac, Wisconsin);  Kirk Jeffrey Hogan (Madison, Wisconsin)
ASSIGNEE(S)
INVENTOR(S) Andy Madrid (Madison, Wisconsin);  Reid Spencer Alisch (Prairie du Sac, Wisconsin);  Kirk Jeffrey Hogan (Madison, Wisconsin)
ABSTRACT Provided herein is technology for Alzheimer's disease testing and particularly, but not exclusively, methods, compositions, and related uses for detecting the presence of Alzheimer's disease.
FILED Friday, July 15, 2022
APPL NO 17/866284
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/686 (20130101) Original (OR) Class
C12Q 2600/154 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372585 Moon et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Complementary and Integrative Health (NCCIH)
National Science Foundation (NSF)
Directorate for Education and Human Resources (EHR)
Division of Graduate Education (DGE)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
Department of Agriculture (USDA)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) Tae Seok Moon (St. Louis, Missouri);  Hyojeong Yi (St. Louis, Missouri);  Matthew Amrofell (St. Louis, Missouri);  Chenggang Xi (St. Louis, Missouri);  Austin Rottinghaus (St. Louis, Missouri)
ASSIGNEE(S) Washington University (St. Louis, Missouri)
INVENTOR(S) Tae Seok Moon (St. Louis, Missouri);  Hyojeong Yi (St. Louis, Missouri);  Matthew Amrofell (St. Louis, Missouri);  Chenggang Xi (St. Louis, Missouri);  Austin Rottinghaus (St. Louis, Missouri)
ABSTRACT Among the various aspects of the present disclosure is the provision of molecular sensors, microbial sensors, constructs, systems, and methods for selectively detecting aromatic compounds.
FILED Wednesday, April 27, 2022
APPL NO 17/731195
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/02 (20130101)
C12Q 1/6897 (20130101) Original (OR) Class

Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms
C12R 2001/19 (20210501)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/9406 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220373061 Varenberg et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) Georgia Tech Research Corporation (Atlanta, Georgia)
ASSIGNEE(S)
INVENTOR(S) Michael Varenberg (Atlanta, Georgia);  Michael Leamy (Atlanta, Georgia);  Yingdan Wu (Atlanta, Georgia)
ABSTRACT A pulley belt (100) for transmitting force from a first pulley (12) to a second pulley (14) includes a belt member (110) having a contact surface (120) configured to be in contact with the first pulley (12) and the second pulley (14). A plurality of projections (122) extends from the contact surface (120). The projections have a predetermined height/diameter aspect ratio. In a method of making a pulley belt, an uncured elastomer (316) is placed in a mold (310) having a shape of a belt member (320) with an inner surface from which patterned projections (312) extend inwardly. The uncured elastomer is cured to form a cured belt member (320), which is removed from the mold (310).
FILED Saturday, October 17, 2020
APPL NO 17/764171
CURRENT CPC
Producing Particular Articles From Plastics or From Substances in a Plastic State
B29D 29/00 (20130101)

Belts, Cables, or Ropes, Predominantly Used for Driving Purposes; Chains; Fittings Predominantly Used Therefor
F16G 1/10 (20130101)
F16G 1/12 (20130101)
F16G 1/28 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220373458 YOUSSEF et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
National Science Foundation (NSF)
APPLICANT(S) San Diego State University (SDSU) Fourndation, dba San Diego State University Research Foundation (San Diego, California)
ASSIGNEE(S)
INVENTOR(S) George YOUSSEF (Solana Beach, California);  Nha Uyen HUYNH (La Jolla, California)
ABSTRACT A testing apparatus for dynamic characterization of a sample of a material under test. A terahertz (THz) time-domain spectroscopy system is configured and arranged to generate and detect terahertz waves to interrogate the sample. A shock wave loading system is configured and arranged to produce a shock wave in the sample concurrently with said THz spectroscopy device interrogating the sample. The sample undergoes changes in an index of refraction in response to the produced ultrafast shock wave in the sample that are detected by the terahertz spectroscopy system.
FILED Friday, October 30, 2020
APPL NO 17/770277
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/41 (20130101)
G01N 21/3586 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220373463 KELLEY et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Army Research Office (CCDC ARO)
National Science Foundation (NSF)
APPLICANT(S) UNIVERSITY OF SOUTH CAROLINA (COLUMBIA, South Carolina)
ASSIGNEE(S)
INVENTOR(S) MATHEW L. KELLEY (COLUMBIA, South Carolina);  ANDREW B. GREYTAK (COLUMBIA, South Carolina);  MVS CHANDRASHEKHAR (COLUMBIA, South Carolina)
ABSTRACT Spatially resolved Fourier Transform Impedance Spectroscopy (FTIS) is disclosed to spatially map and quickly build the frequency response of optoelectronic devices using optical probes. The transfer function of a linear system is the Fourier transform of its impulse response, which may be obtained from transient photocurrent measurements of devices such as photodetectors and solar cells. We apply FTIS to a PbS colloidal quantum dot (QD)/SiC heterojunction photodiode and corroborate results using intensity-modulated photocurrent spectroscopy. The cutoff frequencies of the QD/SiC devices were as high as ˜10 kHz, demonstrating their utility in advanced flexible and thin film electronics. The practical frequencies for FTIS lie in the mHz-kHz range, ideal for composite or novel materials such as QD films that are dominated by interfacial trap states.
FILED Monday, March 07, 2022
APPL NO 17/688230
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/6452 (20130101) Original (OR) Class
G01N 21/6456 (20130101)
G01N 2021/6423 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220373533 Wanunu et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Biological Sciences (BIO)
Division of Molecular and Cellular Biosciences (MCB)
APPLICANT(S) Northeastern University (Boston, Massachusetts);  University of York (Heslington, United Kingdom)
ASSIGNEE(S)
INVENTOR(S) Meni Wanunu (Needham, Massachusetts);  Alfred Antson (Fulford, United Kingdom);  Sandra Greive (York, United Kingdom);  Benjamin Cressiot (Montlignon, France)
ABSTRACT Hybrid nanopores, comprising a protein pore supported within a solid-state membrane, which combine the robust nature of solid-state membranes with the easily tunable and precise engineering of protein nanopores. In an embodiment, a lipid-free hybrid nanopore comprises a water soluble and stable, modified portal protein of the Thermus thermophilus bacteriophage G20c, electrokinetically inserted into a larger nanopore in a solid-state membrane. The hybrid pore is stable and easy to fabricate, and exhibits low peripheral leakage, allowing sensing and discrimination among different types of biomolecules.
FILED Wednesday, June 29, 2022
APPL NO 17/809705
CURRENT CPC
Microstructural Devices or Systems, e.g Micromechanical Devices
B81B 1/002 (20130101)

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 15/00 (20130101)

Peptides
C07K 14/005 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6869 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/48721 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220373543 Gopinath et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S) CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
ASSIGNEE(S)
INVENTOR(S) Ashwin Gopinath (Pasadena, California);  Paul W.K. Rothemund (Pasadena, California)
ABSTRACT Bistable devices are constructed using a polynucleotide platform for sensing molecular events such as binding or conformational changes of target molecules. Uses include measurement of target concentration, measuring the effect of environmental condition (such as heat, light, or pH) on the target, or screening a library for molecules that bind the target or modulate its biological function. Devices comprise three regions: a top lid, bottom lid, and flexible linker or hinge between them. A device has an open configuration in which the top and bottom lid are separated, and a closed configuration they are bound close together. Binding domains or variations of the target molecule are fixed to a device so that when the molecular event occurs, the device switches from open to closed, or vice versa, which generates a signal. Optimal device design is determined by the signal modality (optical or electronic) used to measure closure of surface-immobilized devices.
FILED Thursday, June 02, 2022
APPL NO 17/830901
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/11 (20130101)
C12N 2310/20 (20170501)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/47 (20130101)
G01N 21/553 (20130101)
G01N 21/6428 (20130101)
G01N 33/544 (20130101)
G01N 33/54373 (20130101) Original (OR) Class
G01N 2021/6439 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220373679 Shahrestani
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) MINNOWTECH (Baltimore, Maryland)
ASSIGNEE(S)
INVENTOR(S) Suzan Shahrestani (Baltimore, Maryland)
ABSTRACT The invention relates to the use of sonar acoustic pulses to provide information about the status and composition of aquaculture farming tanks or ponds. In particular, the invention is directed to processes and systems comprising: a acoustic pulse transducer configured to transmit a acoustic pulse into an aquaculture farming tank or pond, a network of underwater sonar signal receivers; a computer connected to the network of underwater sonar signal receivers, said computer having a processor and memory, said memory having computer programming instructions saved thereon and executable on the processor, said computer programming instructions configured for receiving and comparing a signal difference between the acoustic pulse and the scattered return signal and for using the signal difference to output a signal difference data point related to a calculated shrimp biomass and distribution in the aquaculture farming tank or pond; a computer display connected to the computer and configured to display the signal difference data point related the calculated shrimp biomass and distribution.
FILED Thursday, May 20, 2021
APPL NO 17/325219
CURRENT CPC
Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals
A01K 79/00 (20130101)

Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves
G01S 15/10 (20130101)
G01S 15/66 (20130101)
G01S 15/96 (20130101) Original (OR) Class

Electric Digital Data Processing
G06F 21/44 (20130101)
G06F 21/602 (20130101)

Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for
G06Q 40/06 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220374390 CHONG et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computing and Communication Foundations (CCF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Physics (PHY)
APPLICANT(S) THE UNIVERSITY OF CHICAGO (Chicago, Illinois)
ASSIGNEE(S)
INVENTOR(S) Frederic T. CHONG (Chicago, Illinois);  Pranav GOKHALE (Chicago, Illinois);  Yongshan DING (Chicago, Illinois);  Thomas PROPSON (Chicago, Illinois)
ABSTRACT A computing system includes a quantum processor with qubits, a classical memory including a quantum program defining a plurality of instructions in a source language, and a classical processor configured to: (i) receive a circuit of gates representing a quantum program for a variational algorithm in which computation is interleaved with compilation; (ii) identify a plurality of blocks, each block includes a subcircuit of gates, leaving one or more remainder subcircuits of the circuit of gates outside of the plurality of blocks; (iii) pre-compile each block of the plurality of blocks with a pulse generation program to generate a plurality of pre-compiled blocks including control pulses configured to perform the associated block on the quantum processor; and (iv) iteratively execute the quantum program using the pre-compiled blocks as static during runtime and recompiling the one or more remainder subcircuits on the classical processor at each iteration of execution.
FILED Wednesday, September 09, 2020
APPL NO 17/641036
CURRENT CPC
Electric Digital Data Processing
G06F 15/82 (20130101) Original (OR) Class

Computer Systems Based on Specific Computational Models
G06N 10/40 (20220101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220374606 Mosallanezhad et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Army Research Office (CCDC ARO)
Department of the Navy (DON)
Office of Naval Research (ONR)
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Information and Intelligent Systems (IIS)
APPLICANT(S) Ahmadreza Mosallanezhad (Tempe, Arizona);  Ghazaleh Beigi (Tempe, Arizona);  Huan Liu (Tempe, Arizona)
ASSIGNEE(S) Arizona Board of Regents on Behalf of Arizona State University (Tempe, Arizona)
INVENTOR(S) Ahmadreza Mosallanezhad (Tempe, Arizona);  Ghazaleh Beigi (Tempe, Arizona);  Huan Liu (Tempe, Arizona)
ABSTRACT Various embodiments of a system and associated method for anonymization of text without losing semantic utility of text by extracting a latent embedding representation of content with respect to a given task and by learning an optimal strategy for text embedding manipulation to satisfy both privacy and utility requirements are disclosed herein. In particular, the system balances private attribute obfuscation with retained semantic utility.
FILED Tuesday, November 16, 2021
APPL NO 17/527632
CURRENT CPC
Electric Digital Data Processing
G06F 40/30 (20200101) Original (OR) Class

Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 9/6262 (20130101)

Computer Systems Based on Specific Computational Models
G06N 20/00 (20190101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220376120 Meng et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Engineering Education and Centers (EEC)
APPLICANT(S) BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Little Rock, Arkansas)
ASSIGNEE(S)
INVENTOR(S) Xiangbo Meng (Fayetteville, Arkansas);  Rohith Allaparthi (Fayetteville, Arkansas);  Mirsaeid Sarollahi (Fayetteville, Arkansas);  Pijush Kanti Ghosh (Dallas, Texas);  Morgan Ware (Fayetteville, Arkansas)
ABSTRACT A capacitor is provided for high temperature systems. The capacitor includes: a substrate formed from silicon carbide material; a dielectric stack layer, including a first layer deposited on the substrate and a second layer deposited on the first layer; a Schottky contact layer deposited on the second layer; and an Ohmic contact layer deposited on the substrate. The first layer is formed with aluminum nitride (AlN) epitaxially, and the second layer is formed with aluminum oxide (Al2O3). AlN and Al2O3 are ultrawide band gap materials, and as a result, they can be use as the dielectric in the capacitor, allowing the capacitance changes to be less than 10% between −250° C. and 600° C., which is very effective for the high temperature systems.
FILED Tuesday, May 17, 2022
APPL NO 17/746027
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 29/45 (20130101)
H01L 29/94 (20130101) Original (OR) Class
H01L 29/511 (20130101)
H01L 29/518 (20130101)
H01L 29/6606 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220376304 Bolton
FUNDED BY
National Science Foundation (NSF)
Directorate of Technology, Innovation and Partnerships (TIP)
Translational Impacts (TI)
APPLICANT(S) Onas Bolton (Pepper Pike, Ohio)
ASSIGNEE(S)
INVENTOR(S) Onas Bolton (Pepper Pike, Ohio)
ABSTRACT An electrolyte additive is provided. The additive is a quaternary ammonium or phosphonium salt effective to suppress hydrogen evolution and metal dendrite formation during operation of a zinc electrochemical cell such as a zinc-air battery. A zinc battery cell is also provided, which contains an effective amount of the electrolyte additive.
FILED Thursday, July 14, 2022
APPL NO 17/864544
CURRENT CPC
Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/133 (20130101)
H01M 4/244 (20130101)
H01M 10/0567 (20130101) Original (OR) Class
H01M 12/06 (20130101)
H01M 2300/0025 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220377084 Zhang et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Army Research Office (CCDC ARO)
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computer and Network Systems (CNS)
APPLICANT(S) Cornell University (Ithaca, New York)
ASSIGNEE(S)
INVENTOR(S) Fan Zhang (New York, New York);  Sai Krishna Deepak Maram (New York, New York);  Harjasleen Malvai (Ithaca, New York);  Steven Goldfeder (Spring Valley, New York);  Ari Juels (New York, New York)
ABSTRACT A verifier device in one embodiment is configured to communicate over one or more networks with a client device and a server device. The verifier device participates in a three-party handshake protocol with the client device and the server device in which the verifier device and the client device obtain respective shares of a session key of a secure session with the server device. The verifier device receives from the client device a commitment relating to the secure session with the server device, and responsive to receipt of the commitment, releases to the client device additional information relating to the secure session that was not previously accessible to the client device. The verifier device verifies correctness of at least one characterization of data obtained by the client device from the server device as part of the secure session, based at least in part on the commitment and the additional information.
FILED Friday, August 28, 2020
APPL NO 17/636402
CURRENT CPC
Transmission of Digital Information, e.g Telegraphic Communication
H04L 63/126 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220377560 ZENG
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computer and Network Systems (CNS)
APPLICANT(S) UNIVERSITY OF SOUTH CAROLINA (Columbia, South Carolina)
ASSIGNEE(S)
INVENTOR(S) QIANG ZENG (WEST COLUMBIA, South Carolina)
ABSTRACT Secure pairing is key to trustworthy deployment and application of Internet of Things (IoT) devices. However, IoT devices lack conventional user interfaces, such as keyboards and displays, which make many traditional pairing approaches inapplicable. Proximity-based pairing approaches are very usable, but can be exploited by co-located malicious devices. Approaches based on a user's physical operations on IoT devices are more secure, but typically require inertial sensors, while many devices do not satisfy this requirement. A secure and usable pairing approach that can be applied to heterogeneous IoT devices still does not exist. We develop a technique, Universal Operation Sensing, which allows an IoT device to sense the user's physical operations on it without requiring inertial sensors. With this technique, a user holding a smartphone or wearing a wristband can finish pairing in seconds through some very simple operations, e.g., pressing a button or twisting a knob. Moreover, we reveal an inaccuracy issue in original fuzzy commitment and propose faithful fuzzy commitment to resolve it. We design a pairing protocol using faithful fuzzy commitment, and build a prototype system named Touch-to-Pair (T2Pair, for short). The comprehensive evaluation shows that it is secure and usable.
FILED Thursday, March 10, 2022
APPL NO 17/691697
CURRENT CPC
Wireless Communication Networks
H04W 12/06 (20130101)
H04W 12/50 (20210101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 

National Aeronautics and Space Administration (NASA) 

US 20220369664 KOZUBAL et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
Small Business Administration (SBA)
Small Business Technology Transfer (STTR)
APPLICANT(S) The Fynder Group, Inc. (Chicago, Illinois)
ASSIGNEE(S)
INVENTOR(S) Mark A. KOZUBAL (Bozeman, Montana);  Richard E. MACUR (Manhattan, Montana);  Yuval C. AVNIEL (Missoula, Montana);  Maximilian DeVane HAMILTON (Bozeman, Montana)
ABSTRACT Methods of production of edible filamentous fungal biomat formulations are provided as standalone protein sources and/or protein ingredients in foodstuffs as well as a one-time use or repeated use self-contained biofilm-biomat reactor comprising a container with at least one compartment and placed within the compartment(s), a feedstock, a fungal inoculum, a gas-permeable membrane, and optionally a liquid nutrient medium.
FILED Friday, August 05, 2022
APPL NO 17/882490
CURRENT CPC
Protein Compositions for Foodstuffs; Working-up Proteins for Foodstuffs; Phosphatide Compositions for Foodstuffs
A23J 3/20 (20130101) Original (OR) Class
A23J 3/227 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220371718 Zubrin et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
APPLICANT(S) Pioneer Astronautics (Lakewood, Colorado)
ASSIGNEE(S)
INVENTOR(S) Robert Zubrin (Lakewood, Colorado);  Mark Berggren (Lakewood, Colorado)
ABSTRACT Gas Replacement System (GRS) produces lighter than air lift gas from ammonia to enable balloon launch and/or to extend the flight durations of balloons. The GRS produces lighter than air lift gas by dissociating all or part of an ammonia supply into a mixture of nitrogen and hydrogen. The GRS can be used to launch balloons from the ground and/or produce gas for airborne balloons to extend their flight duration. In one embodiment, a GRS includes a tank containing ammonia (e.g., liquid ammonia), a reactor, and a controller operable to direct a release of the ammonia from the tank to the reactor. The controller is also operable to direct the reactor to dissociate at least a portion of the ammonia into a lift gas and exhaust the lift gas from the reactor into the balloon for inflation, the lift gas comprising nitrogen and hydrogen.
FILED Friday, May 20, 2022
APPL NO 17/750120
CURRENT CPC
Lighter-than Air Aircraft
B64B 1/40 (20130101)
B64B 1/62 (20130101) Original (OR) Class
B64B 1/64 (20130101)
B64B 1/70 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220375356 Bateman
FUNDED BY
National Aeronautics and Space Administration (NASA)
APPLICANT(S) Barron Associates, Inc. (Charlottesville, Virginia)
ASSIGNEE(S)
INVENTOR(S) Alec Jacob Devine Bateman (Charlottesville, Virginia)
ABSTRACT Embodiments of a system, device and method improve weather modeling approaches for use by air vehicles to mitigate weather hazards and/or optimize air vehicle operations. Various embodiments collect a set of independent measurements of atmospheric parameters of interest, collect a set of onboard measurements from one or more non-traditional atmospheric sensors onboard an air vehicle, process the collected measurements to identify values of selected atmospheric parameters and generate a model for relating raw sensor outputs from the non-traditional atmospheric sensors to the atmospheric parameters of interest.
FILED Tuesday, May 11, 2021
APPL NO 17/316914
CURRENT CPC
Aeroplanes; Helicopters
B64C 39/024 (20130101)
B64C 2201/125 (20130101)

Traffic Control Systems
G08G 5/0034 (20130101)
G08G 5/0039 (20130101)
G08G 5/0091 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220375641 Venneri et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
NASA Shared Services Center (NSSC)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Ultra Safe Nuclear Corporation (Seattle, Washington)
ASSIGNEE(S)
INVENTOR(S) Paolo Francesco Venneri (Seattle, Washington);  Michael John Eades (Seattle, Washington)
ABSTRACT Passive reactivity control technologies that enable reactivity control of a nuclear thermal propulsion (NTP) system with little to no active mechanical movement of circumferential control drums. By minimizing or eliminating the need for mechanical movement of the circumferential control drums during an NTP burn, the reactivity control technologies simplify controlling an NTP reactor and increase the overall performance of the NTP system. The reactivity control technologies mitigate and counteract the effects of xenon, the dominant fission product contributing to reactivity transients. Examples of reactivity control technologies include, employing burnable neutron poisons, tuning hydrogen pressure, adjusting wait time between burn cycles or merging burn cycles, and enhancement of temperature feedback mechanisms. The reactivity control technologies are applicable to low-enriched uranium NTP systems, including graphite composite fueled and tungsten ceramic and metal matrix (CERMET), or any moderated NTP system, such as highly-enriched uranium graphite composite NTP systems.
FILED Tuesday, July 19, 2022
APPL NO 17/868302
CURRENT CPC
Cosmonautics; Vehicles or Equipment Therefor
B64G 1/408 (20130101)

Nuclear Reactors
G21C 3/62 (20130101)
G21C 5/02 (20130101)
G21C 15/08 (20130101)

Nuclear Power Plant
G21D 5/02 (20130101) Original (OR) Class

Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution
Y02E 30/30 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220376777 BODE et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
APPLICANT(S) ATLAS Space Operations, Inc. (Traverse City, Michigan)
ASSIGNEE(S) ATLAS Space Operations, Inc. (Traverse City, Michigan)
INVENTOR(S) Brad Arnold BODE (Pacific Palisades, California);  Kyle Stephen POLICH (Los Angeles, California)
ABSTRACT Described herein are systems, methods, media, and devices for generating a satellite program for contacting satellites. In some embodiments, data including one or more targets for accessing a satellite constellation is obtained. Based on the data, a set of representations may be generated and candidate satellite constellation access programs may be determined based on the set of representations. For each program, a first score may be computed for each target to obtain a first set of scores, and a second score may be computed for each first score of the first set of scores to obtain a second set of scores. A satellite constellation access program may be selected from the candidate satellite access programs based on the second set of second scores.
FILED Friday, May 21, 2021
APPL NO 17/327068
CURRENT CPC
Transmission
H04B 7/18513 (20130101)
H04B 7/18519 (20130101)
H04B 7/18526 (20130101)
H04B 7/18539 (20130101)
H04B 7/18547 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Agriculture (USDA) 

US 20220372451 Eiteman et al.
FUNDED BY
National Science Foundation (NSF)
Department of Agriculture (USDA)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) University of Georgia Research Foundation, Inc. (Athens, Georgia)
ASSIGNEE(S)
INVENTOR(S) Mark Andrew Eiteman (Athens, Georgia);  William Chris Moxley (Athens, Georgia)
ABSTRACT Modified bacterial strains are provided. The strains can generate a desired product such as pyruvate and products derived from pyruvate. Methods of generating pyruvate and products derived from pyruvate are also provided. The modified bacterial strains have at least one mutation in a gene coding for proteins in a pyruvate dehydrogenase complex such that the mutation allows a cell to accumulate pyruvate and/or products derived from pyruvate.
FILED Tuesday, April 26, 2022
APPL NO 17/729120
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/0008 (20130101) Original (OR) Class

Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture
C12P 7/24 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372509 THOLL et al.
FUNDED BY
Department of Agriculture (USDA)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY (Blacksburg, Virginia)
ASSIGNEE(S)
INVENTOR(S) Dorothea THOLL (Blacksburg, Virginia);  JASON LANCASTER (Blacksburg, Virginia)
ABSTRACT Described herein are engineered polynucleotides and vectors capable of encoding one or more engineered harlequin and/or brown marmorated stink bug pheromone synthesis enzymes. Also described herein are engineered harlequin and/or brown marmorated stink bug pheromone synthesis enzymes. Also described herein are methods of making modified plants capable of expressing one or more harlequin and/or brown marmorated stink bug pheromone synthesis enzymes.
FILED Friday, August 21, 2020
APPL NO 17/637627
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/0081 (20130101)
C12N 9/88 (20130101)
C12N 9/90 (20130101)
C12N 15/8286 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220372585 Moon et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Complementary and Integrative Health (NCCIH)
National Science Foundation (NSF)
Directorate for Education and Human Resources (EHR)
Division of Graduate Education (DGE)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
Department of Agriculture (USDA)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) Tae Seok Moon (St. Louis, Missouri);  Hyojeong Yi (St. Louis, Missouri);  Matthew Amrofell (St. Louis, Missouri);  Chenggang Xi (St. Louis, Missouri);  Austin Rottinghaus (St. Louis, Missouri)
ASSIGNEE(S) Washington University (St. Louis, Missouri)
INVENTOR(S) Tae Seok Moon (St. Louis, Missouri);  Hyojeong Yi (St. Louis, Missouri);  Matthew Amrofell (St. Louis, Missouri);  Chenggang Xi (St. Louis, Missouri);  Austin Rottinghaus (St. Louis, Missouri)
ABSTRACT Among the various aspects of the present disclosure is the provision of molecular sensors, microbial sensors, constructs, systems, and methods for selectively detecting aromatic compounds.
FILED Wednesday, April 27, 2022
APPL NO 17/731195
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/02 (20130101)
C12Q 1/6897 (20130101) Original (OR) Class

Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms
C12R 2001/19 (20210501)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/9406 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220374026 Vougioukas et al.
FUNDED BY
Department of Agriculture (USDA)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) The Regents of the University of California (Oakland, California)
INVENTOR(S) Stavros Vougioukas (Davis, California);  Chen Peng (Davis, California);  Dennis L. Sadowski (Davis, California)
ABSTRACT A system, apparatus and method are provided for robotically assisting the harvest of a crop. Instrumented picker carts include sensors for detecting amounts of harvested crop (e.g., fill ratios) of containers carried by the carts, communication modules for communicating their locations and detected crop amounts to a field computer, and components for signaling for robotic service. The field computer predicts when a cart that requests service will have a full container and where it will be located at that time, then decides whether to approve the request. If the request is approved, a robot is assigned and is given (or generates) a path to the cart's predicted location, and begins moving toward the location so as to arrive near (and preferably before) the predicted time. Robots include means for moving (e.g., wheels, motors, steering components, power sources), navigation modules, computing components for controlling their movement, and communication modules.
FILED Tuesday, May 24, 2022
APPL NO 17/752335
CURRENT CPC
Harvesting; Mowing
A01D 90/16 (20130101)

Systems for Controlling or Regulating Non-electric Variables
G05D 1/0274 (20130101)
G05D 1/0297 (20130101) Original (OR) Class
G05D 2201/0201 (20130101)

Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for
G06Q 10/06316 (20130101)
G06Q 50/02 (20130101)
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Department of Veterans Affairs (DVA) 

US 20220370410 Garcia
FUNDED BY
Department of Veterans Affairs (DVA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
APPLICANT(S) The United States Government As Represented By The Department of Veterans Affairs (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Jose M. Garcia (Seattle, Washington)
ABSTRACT Disclosed are methods of treating muscle loss in a subject comprising administering a therapeutically effective amount of a GHSR1a antagonist, a GHSR1a inverse agonist, a ghrelin antagonist, or a decoy ghrelin receptor to a subject in need thereof. Disclosed are methods of inhibiting the binding of ghrelin to GHSR1a (or GHSR1a to ghrelin) in a subject comprising administering a therapeutically effective amount of GHSR1a antagonist, GHSR1a inverse agonist, ghrelin antagonist, or decoy ghrelin receptor to a subject in need thereof. Also disclosed are methods of inhibiting the binding of ghrelin to GHSR1a (or GHSR1a to ghrelin) in a subject comprising mutating GHSR1a. Disclosed are methods of lowering proteasome activity in a subject comprising administering a therapeutically effective amount of a GHSR1a antagonist, a GHSR1a inverse agonist, a ghrelin antagonist, or a decoy ghrelin receptor to a subject in need thereof. Disclosed are methods of enhancing myogenesis in a subject comprising administering a therapeutically effective amount of a GHSR1a antagonist, a GHSR1a inverse agonist, a ghrelin antagonist, or a decoy ghrelin receptor to a subject in need thereof. Disclosed are methods of increasing mitochondrial biogenesis in a subject comprising administering a therapeutically effective amount of a GHSR1a antagonist, a GHSR1a inverse agonist, a ghrelin antagonist, or a decoy ghrelin receptor to a subject in need thereof.
FILED Tuesday, May 24, 2022
APPL NO 17/752491
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/405 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 21/00 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370415 Eisner et al.
FUNDED BY
Department of Veterans Affairs (DVA)
APPLICANT(S) Kembi Therapeutics Pty Ltd (Carlton, Australia);  The Regents of the University of Michigan (Ann Arbor, Michigan)
ASSIGNEE(S) Kembi Therapeutics Pty Ltd (Carlton, Australia);  The Regents of the University of Michigan (Ann Arbor, Michigan);  The United States Government as represented by The Department of Veterans Affairs (Washington, District of Columbia)
INVENTOR(S) Joel Eisner (Chapel Flill, North Carolina);  Daniel Wahl (Ann Arbor, Michigan);  Corey Speers (Ann Arbor, Michigan)
ABSTRACT The instant invention describes pharmaceutical compositions and dosing regimens comprising radiation therapy and seviteronel with or without dexamethasone, and methods of treating diseases, disorders or symptoms thereof.
FILED Friday, October 11, 2019
APPL NO 17/284200
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/573 (20130101)
A61K 31/4192 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370566 Butler et al.
FUNDED BY
Department of Veterans Affairs (DVA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) Saint Louis University (St. Louis, Missouri);  U.S.DEPARTMENT OF VETERANS' AFFAIRS (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Andrew Alistair Butler (St. Louis, Missouri);  Susan Farr (St. Louis, Missouri);  Clemence Girardet (Paris, France)
ABSTRACT Disclosed are methods and compositions for treating cognitive decline in subjects in need. More specifically, disclosed are methods of administrating exogenous adropin to subjects suffering from, or at risk of, cognitive decline including the aged and those suffering from traumatic brain injury. Also disclosed are subjects who would benefit from such treatment and pharmaceutical acceptable compositions comprising adropin, adropin34-76, and derivatives or variations thereof.
FILED Tuesday, November 12, 2019
APPL NO 17/614035
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/22 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/28 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220370805 Cogan et al.
FUNDED BY
Department of Veterans Affairs (DVA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) Duke University (Durham, North Carolina);  New York University (, None);  U.S. GOVENMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia);  University of Utah Research Foundation (Salt Lake City, Utah);  BLACKROCK MICROSYSTEMS, LLC dba (Salt Lake City, Utah)
ASSIGNEE(S)
INVENTOR(S) Gregory Cogan (Durham, North Carolina);  Jonathan Viventi (Durham, North Carolina);  Nandan Lad (Durham, North Carolina);  Bijan Pesaran (New York, New York);  Virginia Woods (Durham, North Carolina);  Chia-Han Chiang (Durham, North Carolina);  Charles Wang (Durham, North Carolina);  Katrina Barth (Durham, North Carolina);  Werner Doyle (New York, New York);  Patricia Dugan (New York, New York);  Orrin Devinsky (New York, New York);  Sasha Devore (New York, New York);  Daniel Friedman (New York, New York);  Amy Orsborn (New York, New York);  Florian Solzbacher (Salt Lake City, Utah);  Robert Franklin (Salt Lake City, Utah);  Sandeep Negi (Salt Lake City, Utah);  Saket Mulge (Salt Lake City, None)
ABSTRACT The present disclosure provides systems and methods related to electroencephalography (EEG) electrode arrays. In particular, the present disclosure provides systems and methods relating to the manufacture and use of high-resolution electrocorticography (ECOG) electrode arrays and stereoelectroencephalography (SEEG) electrode arrays having various combinations and arrangements of microelectrodes and macroelectrodes for recording and modulating nervous system activity.
FILED Friday, September 18, 2020
APPL NO 17/761369
CURRENT CPC
Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 1/36064 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 

Small Business Administration (SBA) 

US 20220369664 KOZUBAL et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
Small Business Administration (SBA)
Small Business Technology Transfer (STTR)
APPLICANT(S) The Fynder Group, Inc. (Chicago, Illinois)
ASSIGNEE(S)
INVENTOR(S) Mark A. KOZUBAL (Bozeman, Montana);  Richard E. MACUR (Manhattan, Montana);  Yuval C. AVNIEL (Missoula, Montana);  Maximilian DeVane HAMILTON (Bozeman, Montana)
ABSTRACT Methods of production of edible filamentous fungal biomat formulations are provided as standalone protein sources and/or protein ingredients in foodstuffs as well as a one-time use or repeated use self-contained biofilm-biomat reactor comprising a container with at least one compartment and placed within the compartment(s), a feedstock, a fungal inoculum, a gas-permeable membrane, and optionally a liquid nutrient medium.
FILED Friday, August 05, 2022
APPL NO 17/882490
CURRENT CPC
Protein Compositions for Foodstuffs; Working-up Proteins for Foodstuffs; Phosphatide Compositions for Foodstuffs
A23J 3/20 (20130101) Original (OR) Class
A23J 3/227 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220371193 CHU et al.
FUNDED BY
National Science Foundation (NSF)
Directorate of Technology, Innovation and Partnerships (TIP)
Translational Impacts (TI)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Diligent Robotics, Inc. (Austin, Texas)
ASSIGNEE(S)
INVENTOR(S) Vivian Yaw-Wen CHU (Austin, Texas);  Shuai LI (Sammamish, Washington);  Forrest GREEN (Austin, Texas);  Peter WORSNOP (Bethesda, Maryland);  Andrea Lockerd THOMAZ (Austin, Texas)
ABSTRACT Systems, apparatus, and methods are described for robotic learning and execution of skills. A robotic apparatus can include a memory, a processor, sensors, and one or more movable components (e.g., a manipulating element and/or a transport element). The processor can be operatively coupled to the memory, the movable elements, and the sensors, and configured to obtain information of an environment, including one or more objects located within the environment. In some embodiments, the processor can be configured to learn skills through demonstration, exploration, user inputs, etc. In some embodiments, the processor can be configured to execute skills and/or arbitrate between different behaviors and/or actions. In some embodiments, the processor can be configured to learn an environmental constraint. In some embodiments, the processor can be configured to learn using a general model of a skill.
FILED Wednesday, March 09, 2022
APPL NO 17/690197
CURRENT CPC
Manipulators; Chambers Provided With Manipulation Devices
B25J 5/00 (20130101)
B25J 9/06 (20130101)
B25J 9/0081 (20130101)
B25J 9/163 (20130101)
B25J 9/1661 (20130101) Original (OR) Class
B25J 9/1694 (20130101)
B25J 11/0005 (20130101)
B25J 15/00 (20130101)
B25J 19/02 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220371896 Zeller et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) H QUEST VANGUARD, INC. (Pittsburgh, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Kurt W. Zeller (Pittsburgh, Pennsylvania);  George L. Skoptsov (Pittsburgh, Pennsylvania);  Evan T. Musselman (Pittsburgh, Pennsylvania)
ABSTRACT Systems and methods for plasma based synthesis of graphitic materials. The system includes a plasma forming zone configured to generate a plasma from radio-frequency radiation, an interface element configured to transmit the plasma from the plasma forming zone to a reaction zone, and the reaction zone configured to receive the plasma. The reaction zone is further configured to receive feedstock material comprising a carbon containing species, and convert the feedstock material to a product comprising the graphitic materials in presence of the plasma.
FILED Monday, June 13, 2022
APPL NO 17/806619
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 19/088 (20130101)
B01J 19/126 (20130101)
B01J 19/129 (20130101)
B01J 2219/0875 (20130101)
B01J 2219/0894 (20130101)
B01J 2219/0896 (20130101)
B01J 2219/0898 (20130101)

Non-metallic Elements; Compounds Thereof;
C01B 32/184 (20170801) Original (OR) Class

Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams
H05H 1/30 (20130101)
H05H 1/4622 (20210501)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220375641 Venneri et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
NASA Shared Services Center (NSSC)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Ultra Safe Nuclear Corporation (Seattle, Washington)
ASSIGNEE(S)
INVENTOR(S) Paolo Francesco Venneri (Seattle, Washington);  Michael John Eades (Seattle, Washington)
ABSTRACT Passive reactivity control technologies that enable reactivity control of a nuclear thermal propulsion (NTP) system with little to no active mechanical movement of circumferential control drums. By minimizing or eliminating the need for mechanical movement of the circumferential control drums during an NTP burn, the reactivity control technologies simplify controlling an NTP reactor and increase the overall performance of the NTP system. The reactivity control technologies mitigate and counteract the effects of xenon, the dominant fission product contributing to reactivity transients. Examples of reactivity control technologies include, employing burnable neutron poisons, tuning hydrogen pressure, adjusting wait time between burn cycles or merging burn cycles, and enhancement of temperature feedback mechanisms. The reactivity control technologies are applicable to low-enriched uranium NTP systems, including graphite composite fueled and tungsten ceramic and metal matrix (CERMET), or any moderated NTP system, such as highly-enriched uranium graphite composite NTP systems.
FILED Tuesday, July 19, 2022
APPL NO 17/868302
CURRENT CPC
Cosmonautics; Vehicles or Equipment Therefor
B64G 1/408 (20130101)

Nuclear Reactors
G21C 3/62 (20130101)
G21C 5/02 (20130101)
G21C 15/08 (20130101)

Nuclear Power Plant
G21D 5/02 (20130101) Original (OR) Class

Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution
Y02E 30/30 (20130101)
VIEW PATENT @ USPTO: