FedInvent™ Patent Applications
Application Details for Thursday, December 01, 2022
This page was updated on Friday, December 02, 2022 at 12:45 PM GMT
Department of Health and Human Services (HHS)
| US 20220378334 | Ghiasi et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Soheil Ghiasi (Davis, California); Daniel Fong (Davis, California); Kourosh Vali (Davis, California); Begum Kasap (Davis, California); Weitai Qian (Davis, California) |
| ABSTRACT | This disclosure provides a fetal-blood-oxygen-saturation estimation technique using a deep neural network without performing explicit fetal signal extraction from mixed maternal-fetal photoplethysmogram (PPG) signals. In one aspect, the disclosed fetal-blood-oxygen-saturation estimation technique receives multiple channels of PPG signals from two or more photodetectors detecting transabdominal diffused light from two or more light sources emitting two or more distinct wavelengths, wherein the photodetectors and light sources are positioned on a maternal abdomen. Note that each channel of the multiple channels of PPG signals includes mixed maternal-fetal PPG signals. Next, the disclosed estimation technique processes the received PPG signals using a trained deep neural network to directly estimate fetal-blood-oxygen-saturation by: tagging the PPG signals with a set of signal-quality levels; feeding the tagged PPG signals as inputs to the deep neural network; and directly inferring, by the deep neural network, fetal-blood-oxygen-saturation estimations and associated confidence levels based on the tagged PPG signals. |
| FILED | Friday, May 27, 2022 |
| APPL NO | 17/827628 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0205 (20130101) A61B 5/1464 (20130101) Original (OR) Class A61B 5/7267 (20130101) A61B 5/14551 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220378342 | Gao et al. |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Wei Gao (Pasadena, California); Minqiang Wang (Pasadena, California); Yiran Yang (Pasadena, California); Jihong Min (Pasadena, California) |
| ABSTRACT | Systems and methods for a microfluidic biosensor patch and health monitoring system may include an iontophoresis module, a multi-inlet microfluidic sweat collection and sampling module, and a molecularly imprinted polymer (MIP) organic compound sensor module. An iontophoresis module may provide for stimulation of a biofluid sample. A biofluid may be a sweat sample. Stimulation may be achieved via electrostimulation and/or application of hydrogel. A microfluidic sweat collection and sample module may include several adhesive layers with carefully designed inlets, channels, a reservoir, and an outlet for the efficiently collection and sampling of biofluid. A MIP sensor module may quickly and accurately identify concentrations of key metabolites present in a biofluid sample which may indicate certain health conditions. |
| FILED | Wednesday, May 25, 2022 |
| APPL NO | 17/824798 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0002 (20130101) A61B 5/681 (20130101) A61B 5/1477 (20130101) A61B 5/4866 (20130101) A61B 5/14521 (20130101) A61B 5/14532 (20130101) A61B 5/14546 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220378360 | STEDMAN et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George Quintin STEDMAN (Mountain View, California); Kamyar FIROUZI (Palo Alto, California); Butrus T. KHURI-YAKUB (Palo Alto, California); Luis DE LECEA (Stanford, California); Keith Richard MURPHY (Pacifica, California) |
| ABSTRACT | Devices and methods are disclosed related to combined ultrasonic stimulation and photometry. A device can include an ultrasonic transducer and an optical delivery element integrated with the ultrasonic transducer. The ultrasonic transducer can deliver ultrasound energy at a tip of the optical delivery element. In certain embodiments, the optical delivery element can be an optical fiber. A detector can generate an indication of a cell response associated with the delivered ultrasound energy. |
| FILED | Thursday, November 12, 2020 |
| APPL NO | 17/755138 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0071 (20130101) A61B 5/4064 (20130101) Original (OR) Class Sound-producing Devices; Methods or Devices for Protecting Against, or for Damping, Noise or Other Acoustic Waves in General; Acoustics Not Otherwise Provided for G10K 11/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220378500 | Wang et al. |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
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| INVENTOR(S) | Paul J. Wang (Saratoga, California); Meghedi Babakhanian (Sunland, California) |
| ABSTRACT | In certain examples, aspects are directed to an ablation tool or other procedure-specific tool to treat or assess biological tissue (e.g., ablate cardiac tissue) having a first tissue side and a second, opposite tissue side at which a magnetic-draw element is to be located. In a specific example, a first magnetic element is associated with or coupled to a catheter tool having an expandable portion to transition from a first state towards a second state for providing an expanded girth, so that the expandable portion surrounds the first magnetic element and moves the procedure-specific tool, in part by the first magnetic element moving via magnetic attraction. While the first magnetic element and the magnetic-draw element align on either side of the biological tissue, the procedure-specific tool may be used for the procedure. |
| FILED | Monday, November 02, 2020 |
| APPL NO | 17/772422 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 18/1492 (20130101) Original (OR) Class A61B 2018/00577 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220378614 | Keller |
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| APPLICANT(S) | Centricity Vision, Inc. (Carlsbad, California) |
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| INVENTOR(S) | Christopher Guild Keller (El Cerrito, California) |
| ABSTRACT | A surgical device and procedure are provided for smoothly and easily accessing tissue to perform microsurgery, including a capsulotomy of a lens capsule of an eye. The device includes a handpiece with a tip for insertion into an incision in the cornea of the eye. A sliding element is disposed within the handpiece and a suction cup is mounted to the sliding element. The sliding element can be translated to move the suction cup into and out of the handpiece. A compression mechanism associated with the suction cup and the handpiece compresses the suction cup for deployment through the tip of the handpiece. The suction cup can expand inside the anterior chamber into a cutting position on the lens capsule. A cutting element mounted to the suction cup is used to cut a portion of the lens capsule and to remove the portion from the eye. The cutting element may be mounted to a cutting element support structure in a way that prevents heating of the device. |
| FILED | Tuesday, August 09, 2022 |
| APPL NO | 17/883993 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 18/14 (20130101) A61B 18/1402 (20130101) A61B 2018/00291 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 9/0017 (20130101) A61F 9/00754 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220378700 | Mitchell et al. |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
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| INVENTOR(S) | Michael Mitchell (Philadelphia, Pennsylvania); Margaret Billingsley (Hockessin, Delaware); Nathan Singh (St. Louis, Missouri); Carl H. June (Merion Station, Pennsylvania) |
| ABSTRACT | The present invention relates to lipid nanoparticles (LNP) or compositions thereof for delivery of mRNA molecules encoding CAR, nucleic acid molecule, and/or therapeutic agents to selected targets, such as cells. Thus, in various aspects, the present invention also provides methods of preventing or treating diseases or disorders in a subject in need thereof using the said LNPs or compositions thereof. |
| FILED | Monday, October 19, 2020 |
| APPL NO | 17/769893 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1272 (20130101) Original (OR) Class A61K 31/711 (20130101) A61K 39/39 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/87 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220378721 | SRIDHAR et al. |
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| APPLICANT(S) | Xavier University of Louisiana (New Orleans, Louisiana) |
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| INVENTOR(S) | Jayalakshmi SRIDHAR (New Orleans, Louisiana); Melyssa BRATTON (New Orleans, Louisiana); Navneet GOYAL (New Orleans, Louisiana); Vishwajeet JHA (Bihar, India); Richard SCHROEDER (Boston, Massachusetts) |
| ABSTRACT | The present disclosure relates to compounds that act as protein kinase inhibitors, especially CK1δ and/or CK1ε inhibitors, which can be used to treat a serine threonine kinase-dependent disease and condition, such as neurodegenerative diseases like Alzheimer's Disease, and the synthesis of the same. Further, the present disclosure teaches the utilization of such compounds in a treatment for neurodegenerative diseases, including Alzheimer's disease. |
| FILED | Thursday, October 22, 2020 |
| APPL NO | 17/771391 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/122 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220378753 | Sahin et al. |
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| APPLICANT(S) | University of South Carolina (Columbia, South Carolina) |
| ASSIGNEE(S) | University of South Carolina (Columbia, South Carolina) |
| INVENTOR(S) | Ozgur Sahin (Lexington, South Carolina); Campbell Mclnnes (Irmo, South Carolina); Ozge Saatci (Columbia, South Carolina); Chad Beneker (Irmo, South Carolina); Abdol-Hossein Rezaeian (Lexington, South Carolina); Metin Cetin (Columbia, South Carolina) |
| ABSTRACT | Described herein are novel compounds that block the activity of LOX family members having good IC50 values, no cellular toxicity below 10 μM, induce sensitization of the cells to doxorubicin, strong activity in a recombinant LOX/LOXL2 activity, and a chemical structure that is drug-like and does not have a PAINS flag, as well as, methods of treatment using the compounds with respect to cancer, organ fibrosis, neurodegenerative and cardiovascular diseases. |
| FILED | Sunday, March 13, 2022 |
| APPL NO | 17/693371 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/427 (20130101) Original (OR) Class A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220378757 | Cullis et al. |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
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| INVENTOR(S) | Courtney A. Cullis (Bedford, Massachusetts); Krista E. Gipson (Medford, Massachusetts); Yongbo Hu (Winchester, Massachusetts); Shih-Chung Huang (Lexington, Massachusetts); Nathanael S. Gray (Jamaica Plain, Massachusetts); David A. Scott (Newton, Massachusetts); Thomas Gero (Stow, Massachusetts); David Heppner (Brookline, Massachusetts); Tyler Beyett (Brookline, Massachusetts); Ciric To (Medford, Massachusetts); Michael Eck (Brookline, Massachusetts) |
| ABSTRACT | The disclosure relates to a compound of Formula (I), which acts as an allosteric inhibitor of epidermal growth factor receptor (EGFR); pharmaceutical compositions comprising the compound; and methods of treating or preventing kinase-mediated disorders, including cancer and other proliferation diseases. |
| FILED | Friday, June 19, 2020 |
| APPL NO | 17/596720 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/437 (20130101) Original (OR) Class A61K 31/444 (20130101) A61K 31/496 (20130101) A61K 31/506 (20130101) A61K 39/3955 (20130101) Heterocyclic Compounds C07D 471/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220378761 | Parker et al. |
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| APPLICANT(S) | The Regents of The University of Colorado, A Body Corporate (Denver, Colorado); Washington University in St. Louis (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Roy R. Parker (Boulder, Colorado); Siddharth Shukla (Boulder, Colorado); Luis Francisco Zirnberger Batista (St. Louis, Missouri); Hochang Jeong (St. Louis, Missouri) |
| ABSTRACT | The present invention includes the novel therapeutic strategies, systems., and compositions for the treatment of telomere-associated disease or disorder through the inhibition of PAPD5/7. the present invention includes the novel therapeutic application of PAPD5 inhibitors for the treatment of disease conditions that implicate reduced telomerase RNA levels. In particular, the present invention includes the novel therapeutic application of PAPD5 inhibitors for the treatment of dyskeratosis congenita, aplastic anemia, and myelodysplastic syndrome. In one preferred embodiment, the present invention includes the novel therapeutic application of RG7834 for the treatment of disease conditions that implicate reduced telomerase RNA levels. In particular, the present invention includes the novel therapeutic application of RG7834 for the treatment of dyskeratosis congenita, aplastic anemia, and myelodysplastic syndrome. |
| FILED | Thursday, November 05, 2020 |
| APPL NO | 17/775133 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4375 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220378777 | Rodd |
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| APPLICANT(S) | THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Indiana) |
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| INVENTOR(S) | Zachary A. Rodd (Indianapolis, Indiana) |
| ABSTRACT | Various aspects and embodiments disclosed herein relate generally to treating an alcohol use disorder or neuroadaptations. Embodiments include compositions and methods for modelling, treatment, reducing resistance to the treatment, prevention, and diagnosis of a condition/disease associated with alcohol use disorders, or a related clinical condition thereof. Other embodiments include methods and compositions for reducing the effects of adolescent alcohol drinking. |
| FILED | Friday, October 30, 2020 |
| APPL NO | 17/771985 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/135 (20130101) A61K 31/4375 (20130101) A61K 31/4725 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/32 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220378782 | Jaenisch et al. |
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| APPLICANT(S) | Whitehead Institute for Biomedical Research (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Whitehead Institute for Biomedical Research (Cambridge, Massachusetts) |
| INVENTOR(S) | Rudolf Jaenisch (Brookline, Massachusetts); Xin Tang (Quincy, Massachusetts) |
| ABSTRACT | Potassium chloride cotransporter-2 (KCC2) plays a critical role in brain function, and deficiency in KCC2 has been linked to neurological diseases, psychiatric disorders, and central nervous system injuries. In particular, Rett syndrome (RTT), a severe neurodevelopmental disorder caused by mutations in the X-linked gene Methyl CpG binding Protein 2 (MECP2), has been linked to deficits in KCC2. The disclosure reports the use of CRISPR/Cas9 genome-editing technology to generate stem cell-derived, genetically defined KCC2 reporter human neurons for large-scale compound screening. This screening platform has been utilized to identify a number of small molecule compounds that are capable of enhancing KCC2 expression in both wild-type and RTT neurons, as well as organotypical brain slices cultured from wild-type mice. These first-in class compounds may be applied as a novel therapeutic approach to restore the impaired balance between excitation and inhibition observed in neurological diseases, psychiatric disorders, and central nervous system injuries. |
| FILED | Tuesday, April 05, 2022 |
| APPL NO | 17/713880 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/05 (20130101) A61K 31/47 (20130101) A61K 31/404 (20130101) A61K 31/496 (20130101) Original (OR) Class A61K 31/519 (20130101) A61K 31/4525 (20130101) A61K 31/4709 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220378832 | Lim et al. |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
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| INVENTOR(S) | Wendell A. Lim (San Francisco, California); Milos Simic (San Francisco, California); Hideho Okada (San Francisco, California); Kole T. Roybal (San Francisco, California); Joseph H. Choe (San Francisco, California); Payal B. Watchmaker (San Francisco, California) |
| ABSTRACT | A method for treating a subject for glioblastoma is provided. In some embodiments, the method may comprise administering to a subject a molecular circuit that includes a binding triggered transcriptional switch (BTTS) that, when bound to MOG, induces one or more encoded therapeutics specific for one or more antigens expressed by the GBM. Nucleic acids containing sequences encoding all or portions of such circuits are also provided, as well as cells, expression cassettes and vectors that contain such nucleic acids. Also provided are kits for practicing the described methods. |
| FILED | Friday, November 06, 2020 |
| APPL NO | 17/769712 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 38/179 (20130101) A61K 38/1774 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220378841 | MILLAY et al. |
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| APPLICANT(S) | CHILDREN'S HOSPITAL MEDICAL CENTER (Cincinnati, Ohio) |
| ASSIGNEE(S) | CHILDREN'S HOSPITAL MEDICAL CENTER (Cincinnati, Ohio) |
| INVENTOR(S) | Douglas MILLAY (Park Hills, Kentucky); Yasuyuki MITANI (Shinagawa-ku, Tokyo, Japan) |
| ABSTRACT | Some embodiments of the invention include modified cells. Certain embodiments of the invention include methods of using modified cells. Other embodiments of the invention include methods of administering modified cells. Further embodiments of the invention include methods of administering modified cells to treat diseases. Additional embodiments of the invention are also discussed herein. |
| FILED | Thursday, July 09, 2020 |
| APPL NO | 17/597359 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) Original (OR) Class A61K 35/33 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220378852 | SAHA et al. |
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| APPLICANT(S) | BIOMED VALLEY DISCOVERIES, INC. (Kansas City, Missouri); THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Saurabh SAHA (Wellesley Hills, Massachusetts); Shibin Zhou (Owings Mills, Maryland); Bert Vogelstein (Baltimore, Maryland); Kenneth W. Kinzler (Bel Air, Maryland) |
| ABSTRACT | The present invention provides, inter alia, methods for treating or ameliorating an effect of a solid tumor present in a human. These methods include administering intratumorally to the human a unit dose of C. novyi, preferably C. novyi NT, colony forming units (CFUs), which contains about 1×103-1×107 CFUs suspended in a pharmaceutically acceptable carrier or solution. Methods for debulking a solid tumor present in a human, methods for ablating a solid tumor present in a human, a method for microscopically precise excision of tumor cells in a human, methods for treating or ameliorating an effect of a solid tumor that has metastasized to one or more sites in a human, unit doses of C. novyi, preferably C. novyi NT, CFUs, and kits for treating or ameliorating an effect of a solid tumor present in a human are also provided. |
| FILED | Tuesday, August 02, 2022 |
| APPL NO | 17/816924 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/65 (20130101) A61K 35/74 (20130101) Original (OR) Class A61K 35/742 (20130101) A61K 45/06 (20130101) A61K 2035/11 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220378877 | Petri, JR. et al. |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
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| INVENTOR(S) | William A. Petri, JR. (Charlottesville, Virginia); Alexandra N. Donlan (Charlottesville, Virginia) |
| ABSTRACT | Methods and compositions for treating or preventing C. difficile infections, particularly recurring C. difficile infections are described. The compositions for use in treating C. difficile include at least one agent that enhances a biological activity of interleukin-13 (IL-13), such as a recombinant IL-13 peptide or an agent that neutralizes the interleukin-13 (IL-13) decoy receptor, interleukin-13 receptor subunit alpha-2 (IL-13Ra2). Additionally or alternatively, the compositions can include a interleukin-4 (IL-4) peptide. The methods can result in more rapid recovery from CDI and decreased weight loss, e.g., than treatment without the neutralizing agent. |
| FILED | Friday, November 13, 2020 |
| APPL NO | 17/776524 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/426 (20130101) A61K 31/437 (20130101) A61K 31/4164 (20130101) A61K 31/7048 (20130101) A61K 38/14 (20130101) A61K 38/20 (20130101) A61K 38/2026 (20130101) A61K 38/2086 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 16/2866 (20130101) C07K 2317/76 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220378907 | PASARE et al. |
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| APPLICANT(S) | CHILDREN'S HOSPITAL MEDICAL CENTER (Cincinnati, Ohio) |
| ASSIGNEE(S) | CHILDREN'S HOSPITAL MEDICAL CENTER (Cincinnati, Ohio) |
| INVENTOR(S) | Chandrashekhar PASARE (Cincinnati, Ohio); Aakanksha JAIN (Boston, Massachusetts) |
| ABSTRACT | Some embodiments of the invention include methods for treating an animal for a disease comprising one or more administrations of one or more compositions comprising (a) a TNF signaling inhibitor, (b) a CD40 inhibitor, a FAS signaling inhibitor, or both, and (c) optionally, a caspase 8 inhibitor. Other embodiments include methods for treating the disease comprising one or h more administrations of one or more compositions comprising (a) the TNF signaling inhibitor and (b) the CD40 inhibitor. Certain embodiments include methods for treating the disease comprising one or more administrations of one or more compositions comprising (a) the TNF signaling inhibitor, (b) the FAS signaling inhibitor, and (c) optionally, the caspase 8 inhibitor. Still other embodiments include methods for treating a human for autoimmune disease, T cell mediated autoimmune disease, IL-1β mediated autoimmune disease, or cytokine release syndrome. Additional embodiments of the invention are also discussed herein. |
| FILED | Thursday, November 12, 2020 |
| APPL NO | 17/755787 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/05 (20130101) A61K 31/12 (20130101) A61K 31/48 (20130101) A61K 31/135 (20130101) A61K 31/137 (20130101) A61K 31/197 (20130101) A61K 31/353 (20130101) A61K 31/454 (20130101) A61K 31/522 (20130101) A61K 38/1793 (20130101) A61K 39/3955 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220378919 | Gray et al. |
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| FUNDED BY |
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| APPLICANT(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| INVENTOR(S) | Nathanael S. Gray (Stanford, California); Jinhua Wang (Winchester, Massachusetts); Fleur Marcia Ferguson (Boston, Massachusetts); Jie Jiang (Brookline, Massachusetts); Inchul You (Boston, Massachusetts) |
| ABSTRACT | Disclosed are bispecific compounds (degraders) that target ERK5 for degradation. Also disclosed are pharmaceutical compositions containing the degraders and methods of using the compounds to treat cancer and inflammatory diseases. |
| FILED | Thursday, September 24, 2020 |
| APPL NO | 17/761096 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/55 (20170801) A61K 47/545 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220378936 | HUANG et al. |
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| APPLICANT(S) | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Leaf HUANG (Durham, North Carolina); Jianfeng GUO (Chapel Hill, North Carolina) |
| ABSTRACT | Provided herein are methods and compositions for the delivery of a combination of oxiplatin and folinic acid to a cell, tissue, or physiological site. The compositions comprise delivery system complexes comprising liposomes encapsulating dihydrate(1,2-diaminocyclohexane)platinum(II)-folinic acid or delivery system complexes comprising a 5-fluorouracil active metabolite. Also provided herein are methods for the treatment of cancer, wherein the methods comprise administering the delivery system complexes comprising dihydrate(1,2-diaminocyclohexane)platinum(II)-folinic acid or delivery system complexes comprising a 5-fluorouracil active metabolite that have therapeutic activity against the cancer. |
| FILED | Tuesday, October 13, 2020 |
| APPL NO | 17/767816 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/555 (20130101) A61K 47/543 (20170801) A61K 47/6803 (20170801) A61K 47/6911 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220378947 | Maguire et al. |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Casey A. Maguire (Arlington, Massachusetts); David P. Corey (Newton, Massachusetts); Bence Gyorgy (Stoneham, Massachusetts) |
| ABSTRACT | Methods for introducing a gene into a cell of the inner ear, e.g., a cochlear or vestibular cell, e.g., a hair cell, e.g., for therapy, that include the use of exosomes associated with one or more adeno-associated viral (AAV) particles. |
| FILED | Thursday, June 23, 2022 |
| APPL NO | 17/848047 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0046 (20130101) A61K 48/0058 (20130101) A61K 48/0075 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220378950 | ACHILEFU et al. |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Samuel ACHILEFU (St. Louis, Missouri); Kexian LIANG (St. Louis, Missouri); Rui TANG (St. Louis, Missouri) |
| ABSTRACT | The present invention provides compounds that have motifs that target the compounds to cells that express integrins. In particular, the compounds have peptides with one or more RD motifs conjugated to an agent selected from an imaging agent and a targeting agent. The compounds may be used to detect, monitor, and treat a variety of disorders mediated by integrins. |
| FILED | Wednesday, July 06, 2022 |
| APPL NO | 17/811006 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 49/0032 (20130101) A61K 49/0054 (20130101) A61K 49/0056 (20130101) Original (OR) Class A61K 51/088 (20130101) Peptides C07K 7/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57438 (20130101) G01N 33/57492 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220378952 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qiu Wang (Durham, North Carolina); Hyejin Park (Durham, North Carolina) |
| ABSTRACT | Provided are molecular probes for hyperpolarized 15N magnetic resonance spectroscopic imaging (MRSI) and their use for detecting reactive species (e.g., hydrogen peroxide) and imaging of oxidative stress. In particular, 15N-boronobenzyl-4-cyanopyridinium (15N-BBCP) demonstrated highly favorable physicochemical and hyperpolarization properties, including long spin-lattice relaxation time (T1) and distinguishable 15N chemical shift signals, that make it an effective reaction-based sensing probe for non-invasive, real-time detection of H2O2. |
| FILED | Friday, May 13, 2022 |
| APPL NO | 17/744128 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/106 (20130101) Original (OR) Class Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220378975 | Sheikhi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, Canada) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Amir Sheikhi (State College, Pennsylvania); Maryam Tavafoghi (Los Angeles, California); Alireza Khademhosseini (Los Angeles, California) |
| ABSTRACT | The invention provides injectable, tough hydrogels that can be crosslinked in situ on demand using minimally-invasive methods, such as visible light exposure is an unmet medical challenge. Among the emerging biopolymers for tissue sealing, gelatin methacryloyl (GelMA), a naturally-derived biopolymer obtained from denatured collagen, has secured a promising role as a result of its excellent bioadhesion, biodegradation, and biocompatibility. To overcome one of the main shortcomings of GelMA, i.e., brittleness, we hybridized it using methacrylate-modified alginate (AlgMA) to impart ion-induced reversible crosslinking that can dissipate energy under strain. The hybrid GelMA-AlgMA hydrogels provide a photocrosslinkable, injectable, and adhesive platform with an excellent toughness that can be engineered using divalent cations, such as calcium. This class of novel hybrid biopolymers with more than 600% improved toughness may set the stage for durable, mechanically-resilient, and cost-effective tissue sealants in minimally invasive procedure, especially for stretchable tissues. |
| FILED | Wednesday, November 18, 2020 |
| APPL NO | 17/772399 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 24/0015 (20130101) A61L 24/043 (20130101) Original (OR) Class A61L 2400/04 (20130101) Compositions of Macromolecular Compounds C08L 5/04 (20130101) C08L 89/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220379033 | Ryan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Windgap Medical, Inc. (Watertown, Massachusetts) |
| ASSIGNEE(S) | Windgap Medical, Inc. (Watertown, Massachusetts) |
| INVENTOR(S) | Andrew John Ryan (Boston, Massachusetts); Jeffrey Thomas Chagnon (Watertown, Massachusetts); Phillip A. Soucy (Arlington, Virginia) |
| ABSTRACT | A reciprocating medicament mixing and injector system, where the energy provided to transfer medicament components back and forth between containers or cartridges can be redirected to deliver the mixed medicament components. In one embodiment the energy source is a pressurized gas chamber, in another, it is constant force spring, and in another it is a compression spring. |
| FILED | Tuesday, May 31, 2022 |
| APPL NO | 17/829346 |
| CURRENT CPC | Containers Specially Adapted for Medical or Pharmaceutical Purposes; Devices or Methods Specially Adapted for Bringing Pharmaceutical Products into Particular Physical or Administering Forms; Devices for Administering Food or Medicines Orally; Baby Comforters; Devices for Receiving Spittle A61J 1/2027 (20150501) A61J 1/2037 (20150501) A61J 1/2075 (20150501) A61J 1/2089 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/2046 (20130101) A61M 5/2066 (20130101) Original (OR) Class A61M 5/31596 (20130101) A61M 2005/206 (20130101) A61M 2005/2013 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220379109 | Bagwell et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Actuated Medical, Inc. (Bellefonte, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Roger B. Bagwell (Bellefonte, Pennsylvania); Alanoud S. Alsubhi (State College, Pennsylvania); Ryan S. Clement (State College, Pennsylvania); Jenna K. Greaser (State College, Pennsylvania); Eric M. Steffan (Karthaus, Pennsylvania); Natasha N. Tirko (State College, Pennsylvania) |
| ABSTRACT | An implant insertion device includes a vibrational actuator generating axial vibrations, a coupler interconnected to the actuator and selectively retaining an implant with penetrating electrodes. The coupler has a distal end cavity at one end dimensioned to receive and retain at least a portion of the implant. Vibrations are transferred to the electrodes during insertion. A vacuum assembly connects to the coupler and provides a negative pressure, or suction force, when a vacuum source is attached and activated. This suction force is sufficient to hold the implant to the distal end of the coupler. Deactivation of the vacuum source removes the suction force, causing the implant to detach from the coupler without perturbation of position. The insertion device may then be removed. A system to coordinate the operation of the actuator and movement of the device and/or tissue relative to one another for delivery of the implant is also provided. |
| FILED | Friday, March 25, 2022 |
| APPL NO | 17/704698 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 90/08 (20160201) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0534 (20130101) Original (OR) Class A61N 1/0558 (20130101) A61N 1/36007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380236 | Timperman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aaron T. Timperman (Urbana, Illinois); Dayi Chen (Urbana, Illinois); Jin-Tae Kim (Savoy, Illinois); Leonardo P. Chamorro (Mahomet, Illinois) |
| ABSTRACT | An electrodialysis fluid purification device includes a fluid output from an upper part of a first fluid reservoir. One or more ion permselective elements at a surface on or near the bottom of the first reservoir are arranged to provide one or more small area points or lines. A fluid connection to a second fluid reservoir is on an opposite side of the one or more ion permselective elements. Electrodes and a power supply create a voltage differential across the one or more ion permselective elements. Another fluid purification device includes a first reservoir with which an ion permselective element interfaces directly in a 2D to 3D relationship. A method employs small area ion permselective element interfaces at a surface on or near the bottom of the first reservoir such that ion transport creates a depleted zone that extends into the first fluid reservoir. |
| FILED | Monday, May 23, 2022 |
| APPL NO | 17/750712 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/42 (20130101) C02F 1/4693 (20130101) Original (OR) Class C02F 2201/4616 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380298 | Rettig et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); The United States Government represented by the Department of Veteran Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Rettig (Los Angeles, California); Michael E. Jung (Los Angeles, California); D. Elshan Nakath G. Ralalage (Los Angeles, California); Jiabin An (Los Angeles, California) |
| ABSTRACT | The present disclosure provides compounds and methods for inhibiting or degrading the N-terminal domain of the androgen receptor, as well as methods for treating cancers such as prostate cancer. |
| FILED | Thursday, January 13, 2022 |
| APPL NO | 17/575027 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Acyclic or Carbocyclic Compounds C07C 33/486 (20130101) C07C 49/223 (20130101) C07C 225/16 (20130101) Original (OR) Class C07C 235/34 (20130101) C07C 235/78 (20130101) C07C 321/20 (20130101) Heterocyclic Compounds C07D 207/08 (20130101) C07D 211/32 (20130101) C07D 241/04 (20130101) C07D 265/30 (20130101) C07D 303/32 (20130101) C07D 303/40 (20130101) C07D 307/52 (20130101) C07D 333/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380337 | ZHAO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Crinetics Pharmaceuticals, Inc. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jian ZHAO (San Diego, California); Sangdon HAN (San Diego, California); Sun Hee KIM (San Diego, California); Shimiao WANG (San Diego, California); Yunfei ZHU (San Diego, California) |
| ABSTRACT | Described herein are compounds that are somatostatin modulators, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders that would benefit from modulation of somatostatin activity. |
| FILED | Friday, July 01, 2022 |
| APPL NO | 17/810497 |
| CURRENT CPC | Heterocyclic Compounds C07D 401/04 (20130101) Original (OR) Class C07D 401/14 (20130101) C07D 405/14 (20130101) C07D 413/14 (20130101) C07D 471/04 (20130101) C07D 498/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380341 | Smithgall et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); Fox Chase Chemical Development Center, Inc. (Doylestown, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); Fox Chase Chemical Development Center, Inc. (Doylestown, Pennsylvania) |
| INVENTOR(S) | Thomas Smithgall (Wexford, Pennsylvania); Allen Reitz (Doylestown, Pennsylvania); Jay Wrobel (Doylestown, Pennsylvania); Colin Tice (Doylestown, Pennsylvania); Thomas Haimowitz (Doylestown, Pennsylvania); Marianne Carlsen (Doylestown, Pennsylvania); Marie Loughran (Doylestown, Pennsylvania); Hong Ye (Doylestown, Pennsylvania) |
| ABSTRACT | A compound of formula I, or a stereoisomer, tautomer, or pharmaceutically acceptable salt thereof: wherein X1 is benzimidazolyl, substituted benzimidazolyl, azabenzimidazolyl, substituted azabenzimidazolyl, pyrazolyl, or substituted pyrazolyl; X2 is aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, cycloalkyl, substituted cycloalkyl, (cycloalkyl)alkyl, substituted (cycloalkyl)alkyl, heterocycloalkyl, substituted heterocycloalkyl, (heterocycloalkyl)alkyl, substituted (heterocycloalkyl)alkyl, alkyl, substituted alkyl, alkoxycarbonyl, substituted alkoxycarbonyl, dialkylaminocarbonyl, substituted dialkylaminocarbonyl, (heterocycloalkyl)carbonyl, or substituted (heterocycloalkyl)carbonyl; X3 is alkyl, substituted alkyl, alkenyl, substituted alkenyl, heterocycloalkyl, substituted heterocycloalkyl, (heterocycloalkyl)alkyl, substituted (heterocycloalkyl)alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, cycloalkyl, substituted cycloalkyl, (cycloalkyl)alkyl, or substituted (cycloalkyl)alkyl; and X4 is hydroxy, amino, alkyl, or hydrogen. |
| FILED | Thursday, October 17, 2019 |
| APPL NO | 17/285389 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Heterocyclic Compounds C07D 401/14 (20130101) Original (OR) Class C07D 403/04 (20130101) C07D 405/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380359 | Kamenecka et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | AstraZeneca AB (Sodertalje, Sweden); EOLAS THERAPEUTICS, INC. (Carlsbad, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Theodore M. Kamenecka (Palm Beach Gardens, Florida); Jörg Holenz (Bolton, Massachusetts); Steven Wesolowski (Natick, Massachusetts); Yuanjun He (Palm Beach Gardens, Florida); Roland Bürli (Hertfordshire, United Kingdom) |
| ABSTRACT | The present application relates to certain halo-substituted piperidine compounds, pharmaceutical compositions containing them, and methods of using them, including methods for treating substance addiction, panic disorder, anxiety, post-traumatic stress disorder, pain, depression, seasonal affective disorder, an eating disorder, or hypertension. |
| FILED | Wednesday, July 20, 2022 |
| APPL NO | 17/868856 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/34 (20180101) Heterocyclic Compounds C07D 401/14 (20130101) C07D 409/14 (20130101) C07D 413/14 (20130101) C07D 417/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380367 | STELLA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington); THE UNIVERSITY OF MONTANA (Missoula, Montana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nephi STELLA (Seattle, Washington); Philippe DIAZ (Missoula, Montana) |
| ABSTRACT | This disclosure relates to compounds that target microtubules, pharmaceutical compositions comprising them, and methods of using the compounds and compositions for treating diseases. More particularly, this disclosure relates to modified carbazole compounds and pharmaceutical compositions thereof, methods of targeting microtubules with these compounds, and methods of treating diseases affected by microtubule disruption. |
| FILED | Monday, July 18, 2022 |
| APPL NO | 17/813318 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Heterocyclic Compounds C07D 471/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380368 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shaomeng Wang (Superior Township, Michigan); Xin Han (Ann Arbor, Michigan); Weiguo Xiang (Ypsilanti, Michigan); Bukeyan Miao (Ann Arbor, Michigan); Chong Qin (Ann Arbor, Michigan); Lijie Zhao (Ann Arbor, Michigan); Jianfeng Lu (Ann Arbor, Michigan); Tianfeng Xu (Ypsilanti, Michigan); Chao-Yie Yang (Ann Arbor, Michigan) |
| ABSTRACT | The present disclosure provides compounds represented by Formula (I) and the salts or solvates thereof, wherein R3a, E, L, A1, B1, X1, X2, Z1, and Z2 are as defined in the specification. Compounds having Formula (I) are androgen receptor degraders useful for the treatment of cancer and other diseases. |
| FILED | Friday, September 18, 2020 |
| APPL NO | 17/760786 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 13/08 (20180101) A61P 35/00 (20180101) Heterocyclic Compounds C07D 471/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380408 | Johnstone et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, None) |
| INVENTOR(S) | Scott R. Johnstone (Roanoke, Virginia); Brant E. Isakson (Charlottesville, None) |
| ABSTRACT | Provided are peptides that based on the amino acid sequences LDPAKDCGDQKYAY (SEQ ID NO: 1) and LDPSKDCGDPKYAY (SEQ ID NO: 2), optionally wherein the peptide includes an N-terminal stearate modification. Also provided are method for using the disclosed peptides for inhibiting neointima formation in mammals, methods for inhibiting division and/or proliferation of vascular smooth muscle cells, and uses of the disclosed peptides for treating cardiovascular diseases and/or disorder associated with undesirable vascular SMC proliferation, which in some embodiments can re-late to inhibiting neointima formation in a mammal. |
| FILED | Monday, July 27, 2020 |
| APPL NO | 17/630106 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) A61P 35/00 (20180101) Peptides C07K 7/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380409 | Heath et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James R. Heath (Pasadena, California); Rosemary Dyane Rohde (Pasadena, California); Arundhati Nag (Pasadena, California); Samir Das (Pasadena, California); Aiko Umeda (Pasadena, California) |
| ABSTRACT | Peptides having activity as protein binding agents are disclosed. The peptides have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R, R1, L1, L2, G, M, Y1 Y2 and SEQ are as defined herein. Methods associated with preparation and use of such peptides, as well as pharmaceutical compositions comprising such peptides, are also disclosed. |
| FILED | Monday, June 20, 2022 |
| APPL NO | 17/844456 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/0032 (20130101) A61K 49/0041 (20130101) A61K 49/0043 (20130101) A61K 51/08 (20130101) A61K 51/088 (20130101) Peptides C07K 1/047 (20130101) C07K 5/06 (20130101) C07K 5/08 (20130101) C07K 5/10 (20130101) C07K 7/56 (20130101) C07K 7/64 (20130101) Original (OR) Class C07K 14/001 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/573 (20130101) G01N 33/6842 (20130101) G01N 2333/912 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380412 | SAUNDERS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina); Triad National Security, LLC (Los Alamos, New Mexico); The Trustees of The University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin O. SAUNDERS (Durham, North Carolina); Barton F. HAYNES (Durham, North Carolina); Bette T. KORBER (Los Alamos, New Mexico); Kshitij G. WAGH (Los Alamos, New Mexico); Beatrice H. HAHN (Philadelphia, Pennsylvania); Ronnie M. RUSSELL (Philadelphia, Pennsylvania) |
| ABSTRACT | In certain aspects the invention provides HIV-1 immunogens, including HIV-1 envelopes with optimized V2 loop for antibody induction. |
| FILED | Friday, October 23, 2020 |
| APPL NO | 17/771349 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Peptides C07K 14/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2740/16022 (20130101) C12N 2740/16034 (20130101) C12N 2740/16134 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380413 | Kay et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark A. Kay (Los Altos, California); Ren Song (Redwood City, California) |
| ABSTRACT | The present disclosure provides variant adeno-associated virus (AAV) capsid polypeptides that provide an AAV particle with the ability to traverse the human blood brain barrier (BBB) and transduce cells of the CNS. In some embodiment, a subject variant AAV capsid protein includes an amino acid sequence having 95% or more sequence identity (e.g., 96% or more, 97% or more, 98% or more, 99% or more, 99.5% or more, or 100% sequence identity) with the amino acid sequence set forth in any one of SEQ ID NOs: 1-27. Also provided are nucleic acids, AAV vectors, viral particles, cells, kits, and methods. |
| FILED | Wednesday, August 26, 2020 |
| APPL NO | 17/638509 |
| CURRENT CPC | Peptides C07K 14/075 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2750/14122 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380414 | FINZI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CENTRE HOSPITALIER DE L'UNIVERSITÉ DE MONTRÉAL (Montreal, Canada); THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania); THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrés FINZI (St-Bruno-de-Montarville, Canada); Jérémie PRÉVOST (Mirabel, Canada); Marzena PAZGIER (Derwood, Maryland); Amos B. SMITH, III (Merion Station, Pennsylvania) |
| ABSTRACT | Compositions and methods based on the use of mutated HIV-1 gp120 polypeptides having amino acid substitutions at positions 61, 105, 108, 375, 474, 475 and 476 are described. These mutated HIV-1 gp120 polypeptides, which make the HIV env protein more amenable to adopt specific conformations when contacted with gp120 ligands, may be useful as vaccines or tools to identify and characterize agents modulating HIV infection. |
| FILED | Wednesday, September 23, 2020 |
| APPL NO | 17/762333 |
| CURRENT CPC | Heterocyclic Compounds C07D 285/14 (20130101) C07D 333/38 (20130101) Peptides C07K 14/162 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56988 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380415 | Link et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | A. James Link (Belle Mead, New Jersey); Wai Ling Cheung-Lee (Voorhees, New Jersey) |
| ABSTRACT | The present disclosure provides ubonodin peptides, pharmaceutical formulations comprising ubonodin peptides and nucleic acids encoding ubonodin peptides. The disclosure also provides methods of treating Burkholderia infections in a subject in need thereof utilizing the described ubonodin peptides and pharmaceutical formulations. |
| FILED | Friday, August 07, 2020 |
| APPL NO | 17/597987 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 14/195 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380416 | Barber et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Matthew Barber (Eugene, Oregon); Caitlin Kowalski (Eugene, Oregon) |
| ASSIGNEE(S) | University of Oregon (Eugene, Oregon) |
| INVENTOR(S) | Matthew Barber (Eugene, Oregon); Caitlin Kowalski (Eugene, Oregon) |
| ABSTRACT | Compositions including an antibiotic factor from Malassezia are provided. In some examples, the compositions include a Malassezia exoproduct, a Malassezia cell-free supernatant, or a Malassezia cell and a pharmaceutically acceptable carrier. Methods of treating an infection in a subject, such as a Staphylococcus infection are also provided. |
| FILED | Friday, May 27, 2022 |
| APPL NO | 17/827244 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 14/37 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380421 | Bondy-Denomy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph Bondy-Denomy (Oakland, California); Caroline Mahendra (Oakland, California) |
| ABSTRACT | The present disclosure provides Cas9-inhibiting polypeptides and polynucleotides, and methods of using the same to inhibit Cas9 in cells. |
| FILED | Monday, May 02, 2022 |
| APPL NO | 17/734775 |
| CURRENT CPC | Peptides C07K 14/195 (20130101) C07K 14/4703 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/85 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380430 | Srinivasan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Worcester Polytechnic Institute (Worcester, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jagan Srinivasan (Shrewsbury, Massachusetts); Douglas Reilly (Marlborough, Massachusetts); Elizabeth DiLoreto (Jefferson, Massachusetts) |
| ABSTRACT | Kits and methods for rescuing at least one neuropeptide in a subject are described herein, including identifying at least one neuropeptide and recombining a nucleic acid sequence of the neuropeptide to obtain a recombinant nucleic acid neuropeptide; cloning the recombinant nucleic acid neuropeptide into a plasmid to obtain a recombinant neuropeptide plasmid and transforming the recombinant neuropeptide plasmid into a bacterial cell to obtain a transformed neuropeptide bacterial feed; and feeding the bacterial feed to the subject thereby rescuing the neuropeptide in the subject. |
| FILED | Friday, May 20, 2022 |
| APPL NO | 17/749555 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7105 (20130101) A61K 35/74 (20130101) A61K 38/00 (20130101) Peptides C07K 14/57545 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/70 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/68 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380431 | Polt et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robin L. Polt (Tucson, Arizona); Christopher Apostol (Tucson, Arizona); Michael L. Heien (Tucson, Arizona); Chenxi Liu (Tucson, Arizona); John M. Streicher (Tucson, Arizona); Lajos Z. Szabo (Tucson, Arizona); Torsten Falk (Tucson, Arizona) |
| ABSTRACT | Glycopeptide analogs of secretin family peptides, including PACAP and VIP, are described herein. These glycopeptides analogs can have neuroprotective properties and enhanced ability to cross the blood brain barrier (BBB) and/or enhanced stability. These glycosylated peptides can be used as drugs for treatment of CNS disorders, such as Parkinson's disease. |
| FILED | Thursday, August 09, 2018 |
| APPL NO | 16/637702 |
| CURRENT CPC | Peptides C07K 14/72 (20130101) C07K 14/57563 (20130101) Original (OR) Class C07K 2317/41 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380442 | CROWE, Jr. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | Vanderbilt University (Nashville, Tennessee) |
| INVENTOR(S) | James E. CROWE, Jr. (Nashville, Tennessee) |
| ABSTRACT | The present disclosure is directed to antibodies binding to and neutralizing hantavirus and methods for use thereof. |
| FILED | Tuesday, November 10, 2020 |
| APPL NO | 17/775942 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380454 | Zou et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yimin Zou (La Jolla, California); Bo Feng (La Jolla, California); Runyi Tian (La Jolla, California); Andiara Freitas (La Jolla, California) |
| ABSTRACT | Provided herein are methods and agents for modulating the signaling pathway and components thereof that are responsible for assembly and disassembly of synapses in neurons, including amyloid beta (Aβ) mediated synaptotoxicity and synapse loss. Also provided herein are methods for screening and identifying candidate agents capable of modulating synapse formation and (Aβ) mediated synaptotoxicity. |
| FILED | Tuesday, June 23, 2020 |
| APPL NO | 17/623192 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/177 (20130101) Peptides C07K 16/18 (20130101) C07K 16/28 (20130101) Original (OR) Class C07K 2317/76 (20130101) C07K 2319/30 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5041 (20130101) G01N 33/5058 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380457 | CALIGIURI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | City of Hope (Duarte, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael A. CALIGIURI (Pasadena, California); Hongsheng DAI (Monrovia, California); Tongwen ZHANG (Monrovia, California) |
| ABSTRACT | Provided herein are antibodies, recombinant proteins, and methods of use thereof including, for example, immunoglobulin G (IgG) antibodies and recombinant proteins including a Fab region and an Fc region connected through a hinge region, where the hinge region is resistant to cleavage by a protease. Also, provided herein, inter alia, are immunoglobulin G (IgG) antibodies and recombinant proteins including a Fab region and an Fc region connected through a hinge region, and where the Fc region has higher affinity for a ligand compared to a wildtype Fc. |
| FILED | Monday, August 24, 2020 |
| APPL NO | 17/637433 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2803 (20130101) Original (OR) Class C07K 2317/53 (20130101) C07K 2317/72 (20130101) C07K 2317/94 (20130101) C07K 2319/03 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380468 | WARE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sanford Burnham Prebys Medical Discovery Institute (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carl F. WARE (La Jolla, California); John SEDY (La Jolla, California); Paula NORRIS (La Jolla, California) |
| ABSTRACT | The present invention relates to the seminal discovery that BTLA agonist antibodies modulate the immune system. Specifically, the present invention provides antibodies which bind BTLA in the activated state enhancing BTLA signaling. The present invention further provides methods of treating immune and inflammatory diseases and disorders with a BTLA agonist antibody. |
| FILED | Monday, May 16, 2022 |
| APPL NO | 17/745459 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) A61P 37/00 (20180101) Peptides C07K 14/7151 (20130101) C07K 16/2818 (20130101) Original (OR) Class C07K 2317/34 (20130101) C07K 2317/75 (20130101) C07K 2319/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380471 | Ho et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Mitchell Ho (Urbana, Maryland); Ruixue Wang (Bethesda, Maryland); Brad St. Croix (Frederick, Maryland); Dan Li (Rockville, Maryland) |
| ABSTRACT | Single-domain monoclonal antibodies that specifically bind B7H3 (also known as CD276) are described. The single-domain antibodies include camel VHH and rabbit VH domain nanobodies selected from phage display libraries. Chimeric antigen receptors (CARs) and other antibody conjugates targeted to B7H3 are also described. The single-domain antibodies and conjugates thereof can be used for the diagnosis and treatment of B7H3 expressing solid tumors. |
| FILED | Wednesday, October 21, 2020 |
| APPL NO | 17/770940 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2827 (20130101) Original (OR) Class C07K 2317/22 (20130101) C07K 2317/24 (20130101) C07K 2317/565 (20130101) C07K 2317/569 (20130101) C07K 2319/03 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380474 | FitzGerald et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| ASSIGNEE(S) | THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| INVENTOR(S) | David Joseph FitzGerald (Rockville, Maryland); Eric Chun Hei Ho (Rockville, Maryland); Antonella Antignani (Potomac, Maryland); Robert Joseph Sarnovsky (Phoenix, Maryland) |
| ABSTRACT | Disclosed are monoclonal antibodies and antigen binding fragments that specifically bind epidermal growth factor receptor (EGFR) variant (v) III, conjugates thereof, and chimeric antigen receptors. Nucleic acid molecules encoding the heavy and light chain domains of the antibodies, and the chimeric antigen receptors (CARs), are also disclosed, as are host cells expressing the nucleic acid molecules. In addition, disclosed is the use of these monoclonal antibodies, antigen binding fragments, conjugates, and T cells expressing the CARs, such as for the treatment of a tumor expressing EGFRvIII. Also disclosed are methods for detecting a tumor that expresses EGFRvIII. |
| FILED | Wednesday, July 01, 2020 |
| APPL NO | 17/623370 |
| CURRENT CPC | Peptides C07K 14/21 (20130101) C07K 16/2809 (20130101) C07K 16/2863 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/51 (20130101) C07K 2317/55 (20130101) C07K 2317/94 (20130101) C07K 2317/515 (20130101) C07K 2317/565 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380534 | GAO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | The Board of Regents of The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Jinming GAO (Dallas, Texas); Xu WANG (Dallas, Texas); Houliang TANG (Dallas, Texas); Wei LI (Dallas, Texas); Jonathan WILHELM (Dallas, Texas); Baran SUMER (Dallas, Texas) |
| ABSTRACT | The present disclosure relates to degradable polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and have backbones which are capable of undergoing degradation in vivo. In some aspects, the disclosure also provides methods of using these degradable polymers for the delivery of a drug. |
| FILED | Monday, June 22, 2020 |
| APPL NO | 17/620570 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/107 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 65/3332 (20130101) Original (OR) Class C08G 65/3342 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380728 | Wilkinson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | East Carolina University (Greenville, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Stephen Wilkinson (Charlotte, North Carolina); Mark D. Mannie (Greenville, North Carolina) |
| ABSTRACT | FOXP3+ regulatory T cells (Tregs) can represent powerful adoptive immunotherapies for autoimmune diseases, metabolic diseases, and other chronic inflammatory diseases. The present invention is related to the ability to maintain and expand stable Treg lines and can provide insight into FOXP3+ Treg physiology and can enable feasible strategies of Treg-based immunotherapy. |
| FILED | Thursday, June 09, 2022 |
| APPL NO | 17/836176 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 2035/122 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/06 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0637 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380729 | Meyer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior Universty (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Everett Hurteau Meyer (Belmont, California); Robert S. Negrin (Stanford, California) |
| ABSTRACT | The disclosure provides methods for improved hematopoietic stem cell transplantations, including methods to enhance protection from graft versus host disease while maintaining effective immune responses such as graft versus tumor immune responses. The disclosure provides methods for administering, for example, hematopoietic stem and progenitor cells, regulatory T cells, and conventional T cells, wherein the conventional T cells are administered after the hematopoietic stem and progenitor cells and regulatory T cells. The disclosure also provides methods for administering, for example, hematopoietic stem and progenitor cells, regulatory T cells, and conventional T cells, wherein the regulatory T cells have not been cryopreserved prior to administration. |
| FILED | Friday, August 12, 2022 |
| APPL NO | 17/819463 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/436 (20130101) A61K 31/445 (20130101) A61K 35/17 (20130101) A61K 35/28 (20130101) A61K 39/001 (20130101) A61K 2035/122 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) A61P 37/06 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0637 (20130101) C12N 5/0647 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380734 | Tata et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DUKE UNIVERSITY (Durham, North Carolina) |
| ASSIGNEE(S) | DUKE UNIVERSITY (Durham, North Carolina) |
| INVENTOR(S) | Purushothama Rao Tata (Durham, North Carolina); Brigid Hogan (Durham, North Carolina); Hiroaki Katsura (Durham, North Carolina) |
| ABSTRACT | The present disclosure provides systems for growing and, modeling lung cells in organoid cultures and methods of using same. |
| FILED | Monday, September 28, 2020 |
| APPL NO | 17/764040 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0037 (20130101) C12N 5/0068 (20130101) C12N 5/0688 (20130101) Original (OR) Class C12N 2500/90 (20130101) C12N 2533/90 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380757 | BAUER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, None) |
| ASSIGNEE(S) | THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| INVENTOR(S) | Daniel E. BAUER (Cambridge, Massachusetts); Jing ZENG (Brookline, Massachusetts) |
| ABSTRACT | Provided herein are 2′-O-methyl 3′phosphorothioate (MS)-modified synthetic nucleic acid molecules (single guide RNAs (sgRNAs)) in combination with a base editor as a ribonucleoprotein (RNP) complex for an electroporation-based ex vivo targeted gene disruption of the BCL11A erythroid enhancer's +55, +58, or +62, functional regions. Also provided herein are methods relating to the treatment of hemoglobinopathies by reinduction of fetal hemoglobin levels. |
| FILED | Tuesday, September 29, 2020 |
| APPL NO | 17/764413 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) Original (OR) Class C12N 15/907 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380758 | Saito et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| INVENTOR(S) | Makoto Saito (Cambridge, Massachusetts); Feng Zhang (Cambridge, Massachusetts); Guilhem Faure (Cambridge, Massachusetts) |
| ABSTRACT | Systems and methods for targeted gene modification, targeted insertion, perturbation of gene transcripts, and nucleic acid editing. Novel nucleic acid targeting systems comprise components of CRISPR systems and transposable elements. |
| FILED | Friday, October 30, 2020 |
| APPL NO | 17/773104 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) Original (OR) Class C12N 15/63 (20130101) C12N 15/102 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380764 | Brown et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SRI International (Menlo Park, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kathlynn C. Brown (Menlo Park, California); Michael McGuire (Menlo Park, California); Shunzi Li (Menlo Park, California); Indu Venugopal (Menlo Park, California); Curtis Allred (Menlo Park, California) |
| ABSTRACT | Disclosed are compositions comprising a nucleic acid sequence conjugated to one or more MGS peptides. Disclosed are methods of modifying gene expression of a gene of interest comprising administering to a cell a composition comprising a nucleic acid sequence conjugated to one or more MGS peptides, wherein the nucleic acid sequence binds to the RNA transcribed from the gene of interest, the gene of interest or a sequence upstream of the gene of interest. Disclosed are methods of targeting a gene of interest in an intracellular target comprising administering to a cell a composition comprising a nucleic acid sequence conjugated to one or more MGS peptides, wherein the MGS peptide targets the intracellular target, wherein the nucleic acid sequence binds to the RNA transcribed from the gene interest in an intracellular target. |
| FILED | Friday, July 31, 2020 |
| APPL NO | 17/766109 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/711 (20130101) A61K 31/7105 (20130101) A61K 47/64 (20170801) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380765 | HEYMACH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | John V. HEYMACH (Houston, Texas); Jayanthi GUDIKOTE (Houston, Texas); Tina CASCONE (Houston, Texas) |
| ABSTRACT | The present disclosure provides methods of treating cancer in a patient determined to have a p53 mutation by administering an inhibitor of nonsense mediated decay. The patient may be further administered an inhibitor of mRNA splicing and/or an inhibitor of MDM. |
| FILED | Monday, November 02, 2020 |
| APPL NO | 17/773682 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/12 (20130101) A61K 31/122 (20130101) A61K 31/155 (20130101) A61K 31/235 (20130101) A61K 31/365 (20130101) A61K 31/366 (20130101) A61K 31/428 (20130101) A61K 31/496 (20130101) A61K 31/522 (20130101) A61K 31/704 (20130101) A61K 31/706 (20130101) A61K 31/4545 (20130101) A61K 31/4745 (20130101) A61K 31/7036 (20130101) A61K 31/7048 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/14 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380766 | LOPEZ-BERESTEIN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM AKA (Austin, Texas); Consiglio Nazionale delle Ricerche (Roma, Italy) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas); Consiglio Nazionale delle Ricerche (Roma, Italy) |
| INVENTOR(S) | Gabriel LOPEZ-BERESTEIN (Houston, Texas); Paola AMERO (Houston, Texas); Cristian RODRIGUEZ-AGUAYO (Houston, Texas); Rahul MITRA (Houston, Texas); Anil K. SOOD (Houston, Texas); Vittorio DE FRANCISCIS (Naples, Italy); David VOLK (Houston, Texas); Lokesh Ganesh L. RAO (Houston, Texas) |
| ABSTRACT | Provided herein are DNA aptamers targeting AXL receptor kinase. The DNA aptamers may comprise a thiophosphate backbone and be chemically modified. Further provided herein are methods of use thereof for the treatment of a disease or disorder, such as cancer. |
| FILED | Monday, December 16, 2019 |
| APPL NO | 17/413550 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/337 (20130101) A61K 33/243 (20190101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/115 (20130101) Original (OR) Class C12N 2310/16 (20130101) C12N 2310/313 (20130101) C12N 2310/322 (20130101) C12N 2310/351 (20130101) C12N 2310/531 (20130101) C12N 2320/31 (20130101) C12N 2320/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380776 | Humbert et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Fred Hutchinson Cancer Center (Seattle, Washington); University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | Fred Hutchinson Cancer Center (Seattle, Washington); University of Washington (Seattle, Washington) |
| INVENTOR(S) | Olivier Humbert (Seattle, Washington); Hans-Peter Kiem (Seattle, Washington); Roland B. Walter (Seattle, Washington); Andre Lieber (Seattle, Washington); Chang Li (Seattle, Washington) |
| ABSTRACT | Systems and methods to selectively protect therapeutic cells by reducing CD33 expression in the therapeutic cells using base editors and targeting non-therapeutic cells with an anti-CD33 therapy are described. The selective protection results in the enrichment of the therapeutic cells while simultaneously targeting any diseased, malignant and/or non-therapeutic CD33 expressing cells within a subject. |
| FILED | Thursday, October 22, 2020 |
| APPL NO | 17/771128 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0087 (20130101) C12N 5/0647 (20130101) C12N 9/22 (20130101) C12N 15/1138 (20130101) Original (OR) Class C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380777 | Cruse |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | North Carolina State University (Raleigh, North Carolina) |
| INVENTOR(S) | Glenn P. Cruse (Apex, North Carolina) |
| ABSTRACT | Compositions and methods for treating diseases and conditions mediated by the high affinity IgE receptor (FcεRI) are provided. Also provided are antisense oligomers for modulating splicing of mRNA encoding a MS4A6A protein, optionally in addition to antisense oligomers for modulating splicing of mRNA encoding the FcεRIβ protein, thereby down-regulating cell-surface expression of FcεRI, and uses of the antisense oligomers for inhibiting mast cell degranulation, cytokine release, migration, and proliferation; for inhibiting anaphylaxis reactions in individuals, for treating allergic conditions in individuals, for reducing the incidence of allergic reactions in individuals, for treating individuals at risk of developing anaphylactic reactions, and for treating mast cell-related diseases in individuals. |
| FILED | Monday, November 09, 2020 |
| APPL NO | 17/775136 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1138 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/3233 (20130101) C12N 2320/31 (20130101) C12N 2320/33 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380806 | Xu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pin-Xian Xu (New York, New York); Jun Li (New York, New York); Jinshu Xu (New York, New York) |
| ABSTRACT | Provided herein are compositions and methods for treating and preventing hearing loss, for treating and preventing a disorder associated with loss, damage, or absence of sensory auditory hair cells, and/or for improving auditory function in a subject in need thereof. Also provided are compositions and methods for the generation of auditory hair cells that allow perception of stimuli in a subject in need thereof. |
| FILED | Wednesday, November 25, 2020 |
| APPL NO | 17/773675 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/16 (20180101) Peptides C07K 14/4703 (20130101) C07K 14/4705 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380808 | Bloom et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida); Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida); Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| INVENTOR(S) | David C. Bloom (Gainesville, Florida); Alfred S. Lewin (Gainesville, Florida); Donna M. Newmann (Monona, Wisconsin); Zachary L. Watson (Gainesville, Florida); Sonal Sanjeev Tuli (Gainesville, Florida); Gregory Scott Schultz (Gainesville, Florida) |
| ABSTRACT | Aspects of the application relate to methods and compositions for delivering therapeutic nucleic acids to neural cells or tissue in a subject. Additional aspects of the application relate to therapeutic nucleic acids, for example therapeutic ribozymes, that are useful for inhibiting viral reactivation in a subject. |
| FILED | Friday, May 06, 2022 |
| APPL NO | 17/738987 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/22 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/861 (20130101) Original (OR) Class C12N 2750/14143 (20130101) C12N 2830/008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380841 | Willey et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Toledo (Toledo, Ohio) |
| ASSIGNEE(S) | The University of Toledo (Toledo, Ohio) |
| INVENTOR(S) | James C. Willey (Toledo, Ohio); Erin L. Crawford (Toledo, Ohio) |
| ABSTRACT | Described herein are kits and methods for quantifying the amount of at least one nucleic acid of interest in a sample. The kits include a mixture of synthetic spike-in internal standards (IS) reagents, where the spike-in IS reagents comprise a complexity calibration ladder (CCL) that includes synthetic internal standard competitors for at least one target gene. |
| FILED | Friday, November 13, 2020 |
| APPL NO | 17/775932 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) Original (OR) Class C12Q 2600/156 (20130101) C12Q 2600/166 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380944 | MA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cornell University (lthaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Minglin MA (Ithaca, New York); Qingsheng LIU (Ithaca, New York); Xi WANG (Ithaca, New York); James A. FLANDERS (Ithaca, New York) |
| ABSTRACT | The present application relates to fibers having a diameter of 1 nm to 10,000 nm, of one or more biocompatible polymers, wherein the polymers have a backbone which includes a positively charged component from a zwitterionic moiety. Additionally, this application discloses an implantable therapeutic delivery system and its method of formation, comprising a housing defining a chamber, wherein said housing is porous and formed from the fibers. Inside of the housing includes a preparation of cells which release a therapeutic agent from the chamber. The implantable therapeutic delivery system can be used in the treatment of diabetes. |
| FILED | Thursday, April 30, 2020 |
| APPL NO | 17/607896 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 17/005 (20130101) A61L 17/10 (20130101) A61L 17/145 (20130101) A61L 27/18 (20130101) A61L 27/52 (20130101) A61L 27/54 (20130101) A61L 27/56 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 6/70 (20130101) Original (OR) Class D01F 6/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220381734 | Aksimentiev et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois); Technische Universiteit Delft (Delft, Netherlands) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois); Technische Universiteit Delft (Delft, Netherlands) |
| INVENTOR(S) | Aleksei Aksimentiev (Urbana, Illinois); Cornelis Dekker (Den Haag, Netherlands) |
| ABSTRACT | Aspects of the subject disclosure may include, for example, an apparatus comprising: a membrane having a first side and a second side, wherein the membrane has first and second pores disposed therein, a processing system; and a memory that stores executable instructions that, when executed by the processing system, facilitate performance of operations comprising: setting a first physical characteristic in a vicinity of the first pore to cause a first end of a molecule having the first end and a second end to be moved through the first pore; setting a second physical characteristic in a vicinity of the second pore to cause the second end of the molecule to be moved through the second pore; and adjusting the first physical characteristic to cause the molecule to be tightened, with a first given amount of force, between the first pore and the second pore. Additional embodiments are disclosed. |
| FILED | Thursday, May 12, 2022 |
| APPL NO | 17/743190 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/44791 (20130101) Original (OR) Class G01N 33/48721 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220381774 | Bergo |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Adeptrix Corp. (Beverly, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vladislav B. Bergo (Boston, Massachusetts) |
| ABSTRACT | Bead arrays suitable for analysis by mass spectrometry are disclosed. In an embodiment, a bead array includes multiple reactive sites, each of the reactive sites being capable of binding multiple distinct target analytes. |
| FILED | Monday, June 13, 2022 |
| APPL NO | 17/838666 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/745 (20130101) G01N 33/6845 (20130101) G01N 33/6848 (20130101) G01N 33/6854 (20130101) G01N 33/54306 (20130101) Original (OR) Class G01N 33/54313 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220381780 | WOHLSTADTER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Meso Scale Technologies, LLC. (Rockville, Maryland); The United States of America,as represented by the Secretary,Department of Health and Human Services (Rockville, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jacob N. WOHLSTADTER (Palm Beach Gardens, Florida); George SIGAL (Rockville, Maryland); James WILBUR (Germantown, Maryland); Jeffery DEBAD (Ijamsville, Maryland); Hans BIEBUYCK (Potomac, Maryland); Priscilla KRAI (Germantown, Maryland); Alan KISHBAUGH (Rockville, Maryland); Leonid DZANTIEV (Ellicott City, Maryland); Christopher SHELBURNE (Rockville, Maryland); Christopher CAMPBELL (Columbia, Maryland); Anastasia AKSYUK (Rockville, Maryland); Adrian MCDERMOTT (Bethesda, Maryland); Sarah O'CONNELL (Bethesda, Maryland); Sandeep NARPALA (Bethesda, Maryland); Chien Li LIN (Gaithersburg, Maryland) |
| ABSTRACT | The invention relates to methods and kits for determining a SARS-CoV-2 strain in a sample. The invention further provides methods and kits for detecting a single nucleotide polymorphism (SNP) in a target nucleic acid, wherein the target nucleic acid is a SARS-CoV-2 nucleic acid. The invention further provides methods and kits for detecting one or more antibody biomarkers in a sample. |
| FILED | Friday, May 20, 2022 |
| APPL NO | 17/749721 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/582 (20130101) G01N 33/5438 (20130101) G01N 33/56983 (20130101) Original (OR) Class G01N 2333/165 (20130101) G01N 2458/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220381781 | KWONG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GEORGIA TECH RESEARCH CORPORATION (ATLANTA, Georgia) |
| ASSIGNEE(S) | GEORGIA TECH RESEARCH CORPORATION (ATLANTA, Georgia) |
| INVENTOR(S) | Gabriel A. KWONG (Atlanta, Georgia); Shreyas DAHOTRE (Atlanta, Georgia); Yun Min CHANG (Atlanta, Georgia); Adrian HARRIS (Atlanta, Georgia); Fang-Yi SU (Atlanta, Georgia) |
| ABSTRACT | CRISPR-based diagnostic methods and compositions are provided. One embodiment provides the use of DNA-barcoded antibodies or peptide-MHC (pMHC) tetramers (e.g., Kb-OVA257-264, Db-GP10025-33, Db-GP33-41) and CRISPR-Cas protein, and a guided DNA endonuclease, to achieve ultrasensitive detection of soluble and cell surface proteins. The disclosed embodiments can use type V: Cas12a; type VI: Cas13a, or Cas13b. Combining DNA encoding with CRISPR-Cas protein recognition is a sensitive system because barcodes can be isothermally amplified and Cas, for example Cas12a, enzymatically cleaves DNA reporters upon barcode detection, providing two rounds of amplification and enabling measurement of protein concentration by sample fluorescence or using by paper-based assays. This platform enables monitoring of protein and cellular biomarkers and further expands the toolbox of CRISPR/Cas-based technologies |
| FILED | Friday, October 16, 2020 |
| APPL NO | 17/769940 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6804 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/54388 (20210801) G01N 33/56983 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220381784 | CRAIK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles S. CRAIK (San Francisco, California); Sam L. IVRY (San Francisco, California) |
| ABSTRACT | Diagnostic platforms for the detection of mucinous and high grade cysts in the pancreas of subjects are provided. The disclosure provides a system comprising enzyme specific substrate, that are specific for detection and/or quantification of serine protease TPP-1, the value of which corresponding to a determination of whether a mucinous cyst in the pancreas is malignant or benign. The disclosure also provides for a two-step method, in which a sample from a pancreatic cyst is determined mucinous by detection and/or quantification of aspartyl protease expression, and then the same cyst is determined high grade dysplasia or malignant by detection and/or quantification of serine protease expression. |
| FILED | Monday, June 08, 2020 |
| APPL NO | 17/617285 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/37 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57438 (20130101) Original (OR) Class G01N 2333/96411 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220381787 | Gabrilovich et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Wistar Institute of Anatomy and Biology (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dmitry I. Gabrilovich (Villanova, Pennsylvania); Kar Muthumani (Cherry Hill, New Jersey) |
| ABSTRACT | Provided herein is a recombinant antibody or an epitope binding fragment thereof that specifically binds to a lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (LOX-1) epitope, as well as compositions and methods using these antibodies and fragments for therapeutic and diagnostic protocols. |
| FILED | Wednesday, August 12, 2020 |
| APPL NO | 17/634968 |
| CURRENT CPC | Peptides C07K 16/28 (20130101) C07K 2317/31 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57492 (20130101) Original (OR) Class G01N 2333/705 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220381789 | Aspinwall et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona, a body corporate (Tucson, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on Behalf of the University of Arizona, a body corporate (Tucson, Arizona) |
| INVENTOR(S) | Craig A. Aspinwall (Tucson, Arizona); Zeinab Mohktari (Tucson, Arizona); Jon T. Njardarson (Tucson, Arizona); Colleen M. Janczak (Tucson, Arizona); Kevin Scott (Tucson, Arizona) |
| ABSTRACT | The present invention provides compositions and methods for determining a saccharide level in a sample. In particular, compositions and methods of the invention include a boronic acid moiety that forms a complex with a saccharide. |
| FILED | Monday, May 10, 2021 |
| APPL NO | 17/315688 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/66 (20130101) Original (OR) Class G01N 2400/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220381790 | Lysiak et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey J. Lysiak (Crozet, None); Kodimangalam S. Ravichandran (Earlysville, None) |
| ABSTRACT | The presently disclosed subject matter relates to compositions and methods useful for assessing fertilization competency in male and female gametes. In some embodiments, methods, kits, and compositions for identifying, selecting, and functionally evaluating fertilization competent sperm cells are provided, wherein the methods, kits, and compositions employ a reagent that selectively binds phosphatidylserine (PS). |
| FILED | Tuesday, February 11, 2020 |
| APPL NO | 17/429745 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0612 (20130101) C12N 2500/36 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/689 (20130101) Original (OR) Class G01N 2405/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220381863 | Oscanoa Aida et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Julio A. Oscanoa Aida (Stanford, California); Frank Ong (Palo Alto, California); Mert Pilanci (Palo Alto, California) |
| ABSTRACT | In a method for magnetic resonance imaging pseudorandomly undersampled k- space imaging data is acquired with multiple receiver coils of an MRI imaging apparatus. MR image reconstruction is performed to produce a reconstructed MR image from the k-space imaging data by iteratively solving sketched approximations of an original reconstruction problem. The sketched approximations use a sketched model matrix As that is a lower-dimensional version of an original model matrix A of the original reconstruction problem. The sketched model matrix As preserves the Fourier structure of the MR reconstruction problem and reduces the number of coils actively used during reconstruction. |
| FILED | Friday, May 13, 2022 |
| APPL NO | 17/744299 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/543 (20130101) G01R 33/5611 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 11/006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220382538 | Jain et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VigNet Incorporated (Fairfax, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Praduman Jain (Fairfax, Virginia); Dave Klein (Oakton, Virginia); Neeta Jain (Fairfax, Virginia); Yue Cao (Vienna, Virginia) |
| ABSTRACT | In some implementations, a user interface for designing a health management module is provided by a server system. The user interface identifies a plurality of health management templates. The server system initially receives data indicating a user input received through the user interface that selects one of the plurality of module templates. The server system also receives customization parameters that customize the selected module template for a particular organization. The server system then generates a customized health management module for the particular organization based on the selected template and the customization parameters. The server system finally publishes the customized health management module for the particular organization that includes instructions configuring an application provided by a third-party application store. |
| FILED | Monday, August 08, 2022 |
| APPL NO | 17/882697 |
| CURRENT CPC | Electric Digital Data Processing G06F 8/70 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220383464 | BUCKLER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| INVENTOR(S) | Andrew J. BUCKLER (Boston, Massachusetts); Changguo Ji (Lexington, Massachusetts); Murali Ayyapillai (Acton, Massachusetts) |
| ABSTRACT | Systems and methods for improving soft tissue contrast, characterizing tissue, classifying phenotype, stratifying risk, and performing multi-scale modeling aided by multiple energy or contrast excitation and evaluation are provided. The systems and methods can include single and multi-phase acquisitions and broad and local spectrum imaging to assess atherosclerotic plaque tissues in the vessel wall and perivascular space. |
| FILED | Wednesday, July 27, 2022 |
| APPL NO | 17/874617 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/463 (20130101) A61B 6/482 (20130101) A61B 6/504 (20130101) A61B 6/4241 (20130101) A61B 6/5247 (20130101) Image Data Processing or Generation, in General G06T 5/50 (20130101) Original (OR) Class G06T 7/0012 (20130101) G06T 7/174 (20170101) G06T 2207/10081 (20130101) G06T 2207/10088 (20130101) G06T 2207/10132 (20130101) G06T 2207/20216 (20130101) G06T 2207/20224 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220383612 | Udupa et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of The University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jayaram K. Udupa (Philadelphia, Pennsylvania); Dewey Odhner (Horsham, Pennsylvania); Drew A. Torigian (Philadelphia, Pennsylvania); Yubing Tong (Springfield, Pennsylvania) |
| ABSTRACT | A computerized method of providing automatic anatomy recognition (AAR) includes gathering image data from patient image sets, formulating precise definitions of each body region and organ and delineating them following the definitions, building hierarchical fuzzy anatomy models of organs for each body region, recognizing and locating organs in given images by employing the hierarchical models, and delineating the organs following the hierarchy. The method may be applied, for example, to body regions including the thorax, abdomen and neck regions to identify organs. |
| FILED | Thursday, January 06, 2022 |
| APPL NO | 17/569920 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/103 (20130101) A61N 5/1039 (20130101) Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/0012 (20130101) G06T 7/70 (20170101) G06T 7/136 (20170101) G06T 7/143 (20170101) G06T 2207/10081 (20130101) G06T 2207/10088 (20130101) G06T 2207/20016 (20130101) G06T 2207/20128 (20130101) G06T 2207/30004 (20130101) Image or Video Recognition or Understanding G06V 10/457 (20220101) Original (OR) Class G06V 2201/031 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220383986 | Popescu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gabriel Popescu (Urbana, Illinois); Mark A. Anastasio (Champaign, Illinois); Chenfei Hu (Urbana, Illinois); Shenghua He (Urbana, Illinois); Yuchen He (Urbana, Illinois) |
| ABSTRACT | Methods, apparatus, and storage medium for determining a condition of a biostructure by a neural network based on quantitative imaging data (QID) corresponding to an image of the biostructure. The method includes obtaining specific quantitative imaging data (QID) corresponding to an image of a biostructure; determining a context spectrum selection from context spectrum including a range of selectable values by: applying the specific QID to an input layer of a context-spectrum neural network, wherein the context-spectrum neural network is trained, according to a combination of focal loss and dice loss, based on previous QID and constructed context spectrum data associated with the previous QID; mapping the context spectrum selection to the image to generate a context spectrum mask for the image; and determining a condition of the biostructure based on the context spectrum mask. |
| FILED | Friday, May 27, 2022 |
| APPL NO | 17/826392 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/10056 (20130101) G06T 2207/30024 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 40/10 (20190201) G16B 45/00 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20220378334 | Ghiasi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Soheil Ghiasi (Davis, California); Daniel Fong (Davis, California); Kourosh Vali (Davis, California); Begum Kasap (Davis, California); Weitai Qian (Davis, California) |
| ABSTRACT | This disclosure provides a fetal-blood-oxygen-saturation estimation technique using a deep neural network without performing explicit fetal signal extraction from mixed maternal-fetal photoplethysmogram (PPG) signals. In one aspect, the disclosed fetal-blood-oxygen-saturation estimation technique receives multiple channels of PPG signals from two or more photodetectors detecting transabdominal diffused light from two or more light sources emitting two or more distinct wavelengths, wherein the photodetectors and light sources are positioned on a maternal abdomen. Note that each channel of the multiple channels of PPG signals includes mixed maternal-fetal PPG signals. Next, the disclosed estimation technique processes the received PPG signals using a trained deep neural network to directly estimate fetal-blood-oxygen-saturation by: tagging the PPG signals with a set of signal-quality levels; feeding the tagged PPG signals as inputs to the deep neural network; and directly inferring, by the deep neural network, fetal-blood-oxygen-saturation estimations and associated confidence levels based on the tagged PPG signals. |
| FILED | Friday, May 27, 2022 |
| APPL NO | 17/827628 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0205 (20130101) A61B 5/1464 (20130101) Original (OR) Class A61B 5/7267 (20130101) A61B 5/14551 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220378335 | Emaminejad et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Sam Emaminejad (Los Angeles, California); Shuyu Lin (Los Angeles, California); Bo Wang (Los Angeles, California) |
| ABSTRACT | Example implementations also include a method of sensing the presence and quantity of a biochemical by applying a current across a biochemical sensing electrode and a reference electrode, contacting a hydrogel layer to a biological surface, absorbing a biofluid from the biological surface into the hydrogel layer, obtaining, at a processor coupled to the biochemical sensing electrode and the reference electrode, a change in current across the biochemical sensing electrode and the reference electrode, and generating, at the processor, a quantitative biochemical response. Example implementations further include obtaining a biometric encryption key based on the biological surface, and encrypting the quantitative response based on a biometric encryption key. Example implementations further include contacting a fingerprint scanner to the biological surface, and obtaining a fingerprint pattern from the biological surface at the fingerprint scanner, where the biometric encryption key is based on the fingerprint pattern. |
| FILED | Wednesday, October 21, 2020 |
| APPL NO | 17/771003 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/1172 (20130101) A61B 5/1477 (20130101) Original (OR) Class A61B 5/6826 (20130101) A61B 5/14517 (20130101) A61B 5/14546 (20130101) A61B 2562/125 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0866 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20220378377 — AUGMENTED ARTIFICIAL INTELLIGENCE SYSTEM AND METHODS FOR PHYSIOLOGICAL DATA PROCESSING
| US 20220378377 | Au et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Strados Labs, Inc. (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | Strados Labs, Inc. (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Yu Kan Au (West Hartford, Connecticut); Richard Michael Powers (Smyrna, Georgia); Jason Mark Kroh (Locust Grove, Georgia); Nicholas Shane Delmonico (Wilmington, Delaware); Tanziyah Muqeem (Cary, North Carolina) |
| ABSTRACT | In various embodiments, a system for cleaning, marking, and/or interpreting physiological data is disclosed. The system includes a memory having instructions stored thereon, and a processor configured to read the instructions to: receive a training data set comprising physiological data including labeled events corresponding to a predetermined portion of the physiological data, generate a trained artificial intelligence (AI) model configured to identify events within device data, and identify at least one physiological event within a target device data set based on the trained AI model. The trained AI model is generated using an iterative training process based on the training data set. |
| FILED | Monday, March 28, 2022 |
| APPL NO | 17/705585 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/08 (20130101) A61B 5/6801 (20130101) A61B 5/7203 (20130101) Original (OR) Class A61B 5/7267 (20130101) A61B 2560/0242 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220378529 | Frederick et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tom Frederick (Lincoln, Nebraska); Eric Markvicka (Brush, Colorado); Shane Farritor (Lincoln, Nebraska); Dmitry Oleynikov (Omaha, Nebraska) |
| ABSTRACT | The embodiments disclosed herein relate to various robotic and/or in vivo medical devices having compact joint configurations. Other embodiments relate to various medical device components, including forearms having grasper or cautery end effectors, that can be incorporated into certain robotic and/or in vivo medical devices. |
| FILED | Thursday, August 04, 2022 |
| APPL NO | 17/880823 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 18/14 (20130101) A61B 18/1445 (20130101) A61B 34/30 (20160201) Original (OR) Class A61B 2018/1253 (20130101) A61B 2034/305 (20160201) A61B 2217/005 (20130101) A61B 2217/007 (20130101) Manipulators; Chambers Provided With Manipulation Devices B25J 9/046 (20130101) B25J 9/0087 (20130101) B25J 9/102 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220378940 | Kamata et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Neha Prashant Kamata (Evanston, Illinois); Justin Alexander Peruzzi (Evanston, Illinois); Timothy Quang Vu (Evanston, Illinois) |
| ABSTRACT | The present invention provides compositions comprising phase separated nanoparticles, as well as methods of making the nanoparticles and uses thereof. The nanoparticles can be conjugated to therapeutics and used to treat diseases or to screen compounds. |
| FILED | Friday, May 27, 2022 |
| APPL NO | 17/827325 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/1272 (20130101) A61K 47/6811 (20170801) A61K 47/6911 (20170801) A61K 48/0025 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220379124 | Babakhani et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Aydin Babakhani (Los Angeles, California); Hongming Lyu (Los Angeles, California) |
| ABSTRACT | Wirelessly powered implantable pulse generators (IPG) are described. In an embodiment, a wirelessly powered stimulator, includes an implantable pulse generator (IPG), including: an Rx antenna that receives a radio frequency (RF) signal from an external Tx antenna; a rectifier; an energy storage capacitor CSTOR, where the RF signal coupled to the Rx antenna is rectified by the rectifier to generate VDD and charges the CSTOR; a demodulator; an output voltage regulator that generates a stable voltage to activate the demodulator; and where the demodulator outputs a stimulation that releases the energy stored in the CSTOR on an electrode based on detecting amplitude modulation in the received RF signal; and a Tx antenna that generates the RF signal that wirelessly powers the IPG and that controls timing of output stimulations of the IPG, where amplitude modulation is applied to the RF signal to control the timing of the output stimulations. |
| FILED | Wednesday, August 26, 2020 |
| APPL NO | 17/753930 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/3787 (20130101) Original (OR) Class A61N 1/36192 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 50/12 (20160201) H02J 50/27 (20160201) H02J 2207/50 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220379235 | Glezer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ari Glezer (Atlanta, Georgia); Thomas M. Crittenden (Atlanta, Georgia); Sourabh Kumar Jha (Atlanta, Georgia); Pablo Hidalgo (Atlanta, Georgia) |
| ABSTRACT | Low Reynolds number forced convection heat transport within the fin channels enhanced by deliberate formation of unsteady, small-scale vortical motions using elastically fluttering thin-film reeds. The vortical motions substantially increase the local heat transfer coefficient at the channel walls and mixing between the wall thermal boundary layers and the cooler core flow. The flow mechanisms associated with production, advection and dissipation of these small-scale motions are investigated in a modular, high aspect ratio channel using micro-PIV, video imaging of the reed motion, and hot-wire anemometry. The global heat transfer enhancement in a modular heat sink prototype shows that the reed-induced small scale motions increase the turbulent kinetic energy of the flow even when the base flow undergoes transition to turbulence, leading to an increase in the local and global Nusselt number that is sustained at higher Re and a minor relative increase in losses. |
| FILED | Wednesday, September 23, 2020 |
| APPL NO | 17/762177 |
| CURRENT CPC | Separation B01D 5/0033 (20130101) Original (OR) Class Refrigeration Machines, Plants or Systems; Combined Heating and Refrigeration Systems; Heat-pump Systems F25B 39/04 (20130101) Refrigerators; Cold Rooms; Ice-boxes; Cooling or Freezing Apparatus Not Otherwise Provided for F25D 23/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220379309 | Emaminejad et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Sam Emaminejad (Los Angeles, California); Dino Di Carlo (Los Angeles, California); Wenzhuo Yu (Los Angeles, California); Haisong Lin (Los Angeles, California); Yilian Wang (Los Angeles, California) |
| ABSTRACT | An electronically-controlled digital ferrofluidic device is disclosed which employs a network of individually addressable coils in conjunction with one or more movable permanent magnets, where each moveable permanent magnet delivers the designated fluid manipulation-based tasks. The underlying mechanism facilitating fluidic operations is realized by addressable electromagnetic actuation of miniaturized mobile magnets that exert localized magnetic body forces on droplets filled with magnetic nanoparticles. The reconfigurable, contactless, and non-interfering magnetic-field operation properties of the underlying actuation mechanism allow for the integration of passive and active components to implement advanced and diverse operations with high efficiency (e.g., droplet sorting, dispensing, generation, merging, mixing, filtering, and analysis). |
| FILED | Wednesday, October 21, 2020 |
| APPL NO | 17/770959 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) B01L 3/502761 (20130101) Original (OR) Class B01L 2200/0652 (20130101) B01L 2300/0645 (20130101) B01L 2300/0654 (20130101) B01L 2300/0819 (20130101) B01L 2400/043 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1031 (20130101) G01N 15/1404 (20130101) G01N 15/1463 (20130101) G01N 15/1484 (20130101) G01N 2015/149 (20130101) G01N 2015/1006 (20130101) G01N 2015/1422 (20130101) G01N 2015/1493 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220379493 | Rentschler et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark Rentschler (Boulder, Colorado); Vani Sundaram (Boulder, Colorado); Khoi Ly (Boulder, Colorado); Jatin Mayekar (Boulder, Colorado); Nikolaus Correll (Boulder, Colorado) |
| ABSTRACT | A magnetic sensing approach for determining a positioning characteristic of a soft robotic actuator. A magnetic field or a change in magnetic field of a magnetic member may be measured as it undergoes concurrent displacement with a soft actuator. Additionally, an example rolling robotic wheel is illustrated. The robotic wheel may utilize magnetic sensing as described herein. |
| FILED | Tuesday, May 17, 2022 |
| APPL NO | 17/746427 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 15/0085 (20130101) Original (OR) Class Electric Machines Not Otherwise Provided for H02N 1/002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380039 | Bargatin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Igor Bargatin (Wynnewood, Pennsylvania); Zhipeng Lu (Philadelphia, Pennsylvania); Mohsen Azadi (Philadelphia, Pennsylvania) |
| ABSTRACT | Systems and methods for achieving levitation via a photophoretic effect are provided. In certain embodiments, a structure of ultralight materials is provided, for example a BoPET film and carbon nanotubes and has a top and bottom side, made of two separate materials. When the bottom side is illuminated by light at certain intensity, it can result in an upward lift force being applied to the entire structure, causing the structure to levitate. |
| FILED | Thursday, May 12, 2022 |
| APPL NO | 17/742887 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 39/00 (20130101) Original (OR) Class Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/18 (20130101) C08J 2367/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380042 | Chakravarthy |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Animesh Chakravarthy (Arlington, Texas) |
| ABSTRACT | The present disclosure addresses the problem of UAVs pursuing a swarm of target UAVs. The target UAVs are flying together as a flock that are initially modeled as a circle having a time-varying radius or an arbitrarily-shaped swarm that may change in size. Guidance of the pursuing UAVs is developed based on a collision cone framework, wherein the pursuing UAVs cooperatively steer the velocity vector of any point in their convex hull, to intercept the target. Also, the problem of capturing a swarm of intruder UAVs using a net manipulated by a team of defense UAVs is disclosed. The intruder UAV swarm may be stationary, in motion, and even maneuver. Collision cones in 3-dimensional space are used to determine the strategy used by the net carrying UAVs to maneuver or manipulate the net in space in order to capture the intruders. |
| FILED | Thursday, May 06, 2021 |
| APPL NO | 17/313410 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 39/024 (20130101) Original (OR) Class B64C 2201/12 (20130101) B64C 2201/182 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/0022 (20130101) G05D 1/0027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380284 | Holman et al. |
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| FUNDED BY |
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| APPLICANT(S) | Georgetown University (Washington, District of Columbia) |
| ASSIGNEE(S) | Georgetown University (Washington, District of Columbia) |
| INVENTOR(S) | K. Travis Holman (McLean, Virginia); Prashant K. Pandey (Washington, District of Columbia) |
| ABSTRACT | A composition comprising a compound of formula I: wherein n is 5, and R is methyl; and the composition is in an essentially guest-free solid form. |
| FILED | Friday, May 27, 2022 |
| APPL NO | 17/827102 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/22 (20130101) B01J 20/3085 (20130101) General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/13 (20130101) Acyclic or Carbocyclic Compounds C07C 43/205 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380394 | McNally et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (Fort Collins, Colorado) |
| ASSIGNEE(S) | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (Fort Collins, Colorado) |
| INVENTOR(S) | Andrew McNally (Fort Collins, Colorado); Kyle NOTTINGHAM (Fort Collins, Colorado); Chirag PATEL (Fort Collins, Colorado); Jeffrey LEVY (Fort Collins, Colorado); Xuan ZHANG (Fort Collins, Colorado) |
| ABSTRACT | A new set of bench-stable fluoroalkylphosphines that directly convert C—H bonds in pyridine building blocks, drug-like fragments, and pharmaceuticals, into fluoroalkyl derivatives. No pre-installed functional groups or directing motifs are required. The reaction tolerates a variety of sterically and electronically distinct pyridines and is exclusively selective for the 4-position in most cases. The reaction proceeds via initial phosphonium salt formation followed by sp2-sp3 phosphorus ligand-coupling, an underdeveloped manifold for C—C bond formation. |
| FILED | Wednesday, October 20, 2021 |
| APPL NO | 17/634140 |
| CURRENT CPC | General Methods of Organic Chemistry; Apparatus Therefor C07B 47/00 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/572 (20130101) Original (OR) Class C07F 9/5022 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380395 | WOLF et al. |
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| FUNDED BY |
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| APPLICANT(S) | GEORGETOWN UNIVERSITY (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christian WOLF (Arlington, Virginia); Fathima Yushra THANZEEL (Washington, District of Columbia); Kaluvu BALARAMAN (Arlington, Virginia) |
| ABSTRACT | The present invention relates to an analytical method that includes providing a sample potentially containing a chiral analyte that can exist in stereoisomeric forms, and providing a probe selected from the group consisting of coumarin-derived Michael acceptors, dinitrofluoroarenes and analogs thereof, arylsulfonyl chlorides and analogs thereof, arylchlorophosphines and analogs thereof, aryl halophosphites, and halodiazaphosphites. The sample is contacted with the probe under conditions to permit covalent binding of the probe to the analyte, if present in the sample; and, based on any binding that occurs, the absolute configuration of the analyte in the sample, and/or the concentration of the analyte in the sample, and/or the enantiomeric composition of the analyte in the sample is/are determined. The probe may be a coumarin-derived Michael acceptor, a di nitrofluoroarene or analog thereof, an arylsulfonyl chloride or analog thereof, an arylchlorophosphine or analog thereof, an aryl halophosphite, or a halodiazaphosphite. |
| FILED | Tuesday, July 30, 2019 |
| APPL NO | 17/265147 |
| CURRENT CPC | Heterocyclic Compounds C07D 311/18 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/52 (20130101) C07F 9/65744 (20130101) C07F 9/65848 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/33 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380431 | Polt et al. |
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| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robin L. Polt (Tucson, Arizona); Christopher Apostol (Tucson, Arizona); Michael L. Heien (Tucson, Arizona); Chenxi Liu (Tucson, Arizona); John M. Streicher (Tucson, Arizona); Lajos Z. Szabo (Tucson, Arizona); Torsten Falk (Tucson, Arizona) |
| ABSTRACT | Glycopeptide analogs of secretin family peptides, including PACAP and VIP, are described herein. These glycopeptides analogs can have neuroprotective properties and enhanced ability to cross the blood brain barrier (BBB) and/or enhanced stability. These glycosylated peptides can be used as drugs for treatment of CNS disorders, such as Parkinson's disease. |
| FILED | Thursday, August 09, 2018 |
| APPL NO | 16/637702 |
| CURRENT CPC | Peptides C07K 14/72 (20130101) C07K 14/57563 (20130101) Original (OR) Class C07K 2317/41 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380500 | Elder et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Delwin Elder (Seattle, Washington); Huajun Xu (Seattle, Washington); Bruce H. Robinson (Seattle, Washington); Larry R. Dalton (Seattle, Washington) |
| ABSTRACT | Crosslinked films having electro-optic activity, compositions and compounds for making the films, methods for making the films, and devices that include the films are disclosed. |
| FILED | Wednesday, July 01, 2020 |
| APPL NO | 17/624519 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 220/14 (20130101) Original (OR) Class Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/24 (20130101) C08J 5/18 (20130101) C08J 2333/12 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/3617 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380556 | GAO et al. |
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| FUNDED BY |
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| APPLICANT(S) | ARYTHA BIOSCIENCES, LLC (San Diego, California) |
| ASSIGNEE(S) | ARYTHA BIOSCIENCES, LLC (San Diego, California) |
| INVENTOR(S) | Weiwei GAO (La Jolla, California); Che-Ming Jack HU (Taipei City, Taiwan) |
| ABSTRACT | The present invention relates to processes and systems for preparing nanoparticles, cellular or viral membranes and/or cellular or viral membrane coated nanoparticles using or comprising, inter alia, a multi-inlet vortexing reactor, tangential flow filtration (TFF) and/or a high shear fluid processor such as a microfluidizer (or a microfluidizer processor). The present invention also relates to the nanoparticles, cellular or viral membranes and/or cellular or viral membrane coated nanoparticles prepared by the present processes and systems, and the uses and/or applications of the nanoparticles, cellular or viral membranes and/or cellular or viral membrane coated nanoparticles. |
| FILED | Thursday, June 09, 2022 |
| APPL NO | 17/836571 |
| CURRENT CPC | Separation B01D 61/146 (20220801) B01D 2315/16 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/12 (20130101) Original (OR) Class C08J 2367/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380601 | Delcamp et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Mississippi (University, Mississippi) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jared Heath Delcamp (Oxford, Mississippi); Roberta Ramalho Rodrigues (Oxford, Mississippi); Adithya Peddapuram (Oxford, Mississippi); Hammad Arshad Cheema (Lahore, Pakistan); Christine Curiac (Oxford, Mississippi) |
| ABSTRACT | Provided herein are dyes, dye-sensitized solar cells, and sequential series multijunction dye-sensitized solar cell devices. The dyes include an electron deficient acceptor moiety, a medium electron density π-bridge moiety, and an electron rich donor moiety comprising a biaryl, a substituted biaryl, or an R1, R2, R3 substituted phenyl where each of R1, R2, and R3 independently comprises H, aryl, multiaryl, alkyl substituted aryl, alkoxy substituted aryl, alkyl substituted multiaryl, alkoxy substituted multiaryl, OR4, N(R5)2, or a combination thereof, each R4 independently comprises H, alkyl, aryl, alkyl substituted aryl, alkoxy substituted aryl, or a combination thereof; and each R5 independently comprises aryl, multiaryl, alkyl substituted aryl, alkoxy substituted aryl, alkyl substituted multiaryl, alkoxy substituted multiaryl, or a combination thereof. The solar cells include a glass substrate, a dye-sensitized active layer, and a redox shuttle. The devices include at least two dye-sensitized solar cells connected in series. |
| FILED | Wednesday, June 22, 2022 |
| APPL NO | 17/808246 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 15/065 (20130101) Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 23/0058 (20130101) Original (OR) Class Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 9/2018 (20130101) H01G 9/2059 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0064 (20130101) H01L 51/0096 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380779 | DIETRICH et al. |
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| FUNDED BY |
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| APPLICANT(S) | LYGOS, INC. (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey DIETRICH (Berkeley, California); Andrew CONLEY (Berkeley, California); Christine CARLE (Berkeley, California); Nathan MIH (Berkeley, California); Chang-ting CHEN (Berkeley, California); Shuchi DESAI (Berkeley, California); Ee-been GOH (Berkeley, California); Poh TENG (Berkeley, California) |
| ABSTRACT | Provided herein are systems and methods for the production of malonic acid or a salt thereof in recombinant host cells. |
| FILED | Monday, August 31, 2020 |
| APPL NO | 17/753249 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/16 (20130101) C12N 15/52 (20130101) Original (OR) Class Enzymes C12Y 102/01004 (20130101) C12Y 301/02004 (20130101) C12Y 401/01001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380783 | Zhang et al. |
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| FUNDED BY |
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| APPLICANT(S) | Rong Zhang (Chandler, Arizona); Hanah Goetz (Tempe, Arizona); Juan Melendez-Alvarez (Tempe, Arizona); Xiao Wang (Chandler, Arizona); Xiaojun Tian (Chandler, Arizona) |
| ASSIGNEE(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| INVENTOR(S) | Rong Zhang (Chandler, Arizona); Hanah Goetz (Tempe, Arizona); Juan Melendez-Alvarez (Tempe, Arizona); Xiao Wang (Chandler, Arizona); Xiaojun Tian (Chandler, Arizona) |
| ABSTRACT | Described herein are a synthetic cascading bistable switches (Syn-CBS) circuit. In some aspects, the SynCBS circuit is single-strain circuit with two coupled self-activation modules to achieve two successive cell fate transitions. In other aspects, the SynCBS circuit is a two-strain circuit where the self-activation modules are divided in two cells instead of being expressed in a single cell. Also described are plasmids encoding the Syn-CBS circuits. |
| FILED | Friday, May 06, 2022 |
| APPL NO | 17/738333 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/635 (20130101) Original (OR) Class C12N 2830/002 (20130101) C12N 2830/15 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380811 | Church et al. |
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| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George M. Church (Brookline, Massachusetts); James Dicarlo (Boston, Massachusetts) |
| ABSTRACT | Methods of multiplex genome engineering in cells using Cas9 is provided which includes a cycle of steps of introducing into the cell a first foreign nucleic acid encoding one or more RNAs complementary to the target DNA and which guide the enzyme to the target DNA, wherein the one or more RNAs and the enzyme are members of a co-localization complex for the target DNA, and introducing into the cell a second foreign nucleic acid encoding one or more donor nucleic acid sequences, and wherein the cycle is repeated a desired number of times to multiplex DNA engineering in cells. |
| FILED | Friday, June 10, 2022 |
| APPL NO | 17/837089 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) C12N 15/902 (20130101) Original (OR) Class C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380839 | Eun et al. |
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| FUNDED BY |
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| APPLICANT(S) | BIOO Scientific Corporation (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Suk Ho Eun (Austin, Texas); Adam R. Morris (Austin, Texas) |
| ABSTRACT | Methods and kits for depleting amplicons that correspond to undesired RNA species present in a sample are provided. The disclosed methods and kits employ a blocker that anneals with at least a portion of the undesired RNA, resulting in a duplex that is not a suitable substrate for ligating an adapter to the end of the undesired RNA. |
| FILED | Thursday, August 11, 2022 |
| APPL NO | 17/886126 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/6806 (20130101) C12Q 1/6811 (20130101) C12Q 1/6832 (20130101) C12Q 1/6848 (20130101) Original (OR) Class C12Q 1/6855 (20130101) C12Q 1/6874 (20130101) C12Q 1/6888 (20130101) C12Q 2600/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380893 | CHANG et al. |
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| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christina M. CHANG (Cambridge, Massachusetts); Luke M. DAVIS (Cambridge, Massachusetts); Roy Gerald GORDON (Cambridge, Massachusetts) |
| ABSTRACT | Articles are described including a substrate and a copper halide layer on the substrate, where the interfacial free energy between the substrate and the copper halide layer allows the copper halide layer to form continuously, wherein the copper halide layer conforms to the shape of the substrate. The articles may further include an adhesion layer disposed in-between the substrate and the copper halide layer, where the surface free energy between the adhesion layer and the copper halide layer allows the copper halide layer to form continuously, wherein the copper halide layer or the adhesion layer conform to the shape of the substrate. Also described are methods of forming an article using chemical vapor deposition. |
| FILED | Friday, June 12, 2020 |
| APPL NO | 17/618217 |
| CURRENT CPC | Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 3/05 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/30 (20130101) Original (OR) Class C23C 16/0272 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/4293 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380909 | Houchins et al. |
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| FUNDED BY |
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| APPLICANT(S) | CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregory Houchins (Pittsburgh, Pennsylvania); Venkatasubramanian Viswanathan (Pittsburgh, Pennsylvania) |
| ABSTRACT | In some aspects, the present disclosure pertains to methods for the electrochemical production of calcium silicate compounds in an electrochemical cell that comprises (a) a Ca-based electrode that comprises calcium metal or an inorganic calcium material, (b) an SiOx-based electrode that comprises a SiOx material, where x ranges from 1 to 2, and (c) a liquid electrolyte disposed between the Ca-based electrode and the SiOx-based electrode. In these methods, the electrochemical cell is operated under conditions such that calcium cations are produced at the Ca-based electrode and one or more calcium silicate (Ca—Si-oxide) compounds are produced at the SiOx-based electrode. In other aspects, the present disclosure pertains to systems for the electrochemical production of calcium silicate compounds. |
| FILED | Wednesday, October 28, 2020 |
| APPL NO | 17/771197 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/18 (20130101) Original (OR) Class C25B 9/19 (20210101) C25B 11/042 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380918 | PHAM et al. |
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| FUNDED BY |
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| APPLICANT(S) | ELECTRASTEEL, INC. (Boulder, Colorado) |
| ASSIGNEE(S) | ELECTRASTEEL, INC. (Boulder, Colorado) |
| INVENTOR(S) | Ai Quoc PHAM (Boulder, Colorado); Sandeep NIJHAWAN (Boulder, Colorado); Adolfredo ALVAREZ (Boulder, Colorado); Steven FATUR (Boulder, Colorado) |
| ABSTRACT | Methods and systems for dissolving an iron-containing ore are disclosed. For example, a method of processing and dissolving an iron-containing ore comprises: thermally reducing one or more non-magnetite iron oxide materials in the iron-containing ore to form magnetite in the presence of a reductant, thereby forming thermally-reduced ore; and dissolving at least a portion of the thermally-reduced ore using an acid to form an acidic iron-salt solution; wherein the acidic iron-salt solution comprises protons electrochemically generated in an electrochemical cell. |
| FILED | Tuesday, August 09, 2022 |
| APPL NO | 17/884198 |
| CURRENT CPC | Production and Refining of Metals; Pretreatment of Raw Materials C22B 5/00 (20130101) Processes for the Electrolytic Production, Recovery or Refining of Metals; Apparatus Therefor C25C 1/06 (20130101) Original (OR) Class C25C 7/02 (20130101) C25C 7/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380919 | PHAM et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ELECTRASTEEL, INC. (Boulder, Colorado) |
| ASSIGNEE(S) | ELECTRASTEEL, INC. (Boulder, Colorado) |
| INVENTOR(S) | Ai Quoc PHAM (Boulder, Colorado); Sandeep NIJHAWAN (Boulder, Colorado); Adolfredo ALVAREZ (Boulder, Colorado); Colleen WALLACE (Boulder, Colorado); Steven FATUR (Boulder, Colorado) |
| ABSTRACT | Methods and systems for producing are disclosed. A method for producing iron, for example, comprises: providing an iron-containing ore to a dissolution subsystem comprising a first electrochemical cell; wherein the first anolyte has a different composition than the first catholyte; dissolving at least a portion of the iron-containing ore using an acid to form an acidic iron-salt solution having dissolved first Fe3+ ions; providing at least a portion of the acidic iron-salt solution to the first cathodic chamber; first electrochemically reducing said first Fe3+ ions in the first catholyte to form Fe2+ ions; transferring the formed Fe2+ ions from the dissolution subsystem to an iron-plating subsystem having a second electrochemical cell; second electrochemically reducing a first portion of the transferred formed Fe2+ ions to Fe metal at a second cathode of the second electrochemical cell; and removing the Fe metal. |
| FILED | Tuesday, August 09, 2022 |
| APPL NO | 17/884260 |
| CURRENT CPC | Processes for the Electrolytic Production, Recovery or Refining of Metals; Apparatus Therefor C25C 1/06 (20130101) Original (OR) Class C25C 7/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380922 | Takshi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arash Takshi (Tampa, Florida); Sabrina Marie Rosa-Ortiz (Tampa, Florida) |
| ABSTRACT | A hydrogen evolution assisted electroplating nozzle includes a nozzle tip configured to interface with a portion of a substructure. The nozzle also includes an inner coaxial tube connected to a reservoir containing an electrolyte and an anode, the inner coaxial tube configured to dispense the electrolyte through the nozzle tip onto the portion of the substructure. The nozzle also includes an outer coaxial tube encompassing the inner coaxial tube, the outer coaxial tube configured to extract the electrolyte from the portion of the substructure. The nozzle also includes at least one contact pin configured to make electrical contact with a conductive track on the substrate. |
| FILED | Tuesday, January 04, 2022 |
| APPL NO | 17/568621 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 5/02 (20130101) C25D 5/003 (20130101) Original (OR) Class C25D 5/54 (20130101) C25D 17/005 (20130101) C25D 17/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380943 | Gonzalez et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Grant Michael Gonzalez (Somerville, Massachusetts); John F. Zimmerman (Boston, Massachusetts); Kevin Kit Parker (Cambridge, Massachusetts) |
| ABSTRACT | System, devices and methods for the fabrication of polymeric fibers, as well as resulting polymeric fibers, polymeric fiber materials and uses thereof are described. The polymeric fibers include poly(para-phenylene terephthalamide) (PPTA) fibers having an average fiber diameter in a range of 300 nm to 3 μm, and having an average Young's modulus in a range of 1 GPa to 100 GPa. Some materials including a plurality of the polymeric fibers have a thermal conductivity (k) in a range of 0.005 W/(m·K) to 10 W/(m·K) as measured perpendicular to a plane of the material. |
| FILED | Friday, October 30, 2020 |
| APPL NO | 17/771530 |
| CURRENT CPC | Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/06 (20130101) D01D 5/18 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 6/605 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220381774 | Bergo |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Adeptrix Corp. (Beverly, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vladislav B. Bergo (Boston, Massachusetts) |
| ABSTRACT | Bead arrays suitable for analysis by mass spectrometry are disclosed. In an embodiment, a bead array includes multiple reactive sites, each of the reactive sites being capable of binding multiple distinct target analytes. |
| FILED | Monday, June 13, 2022 |
| APPL NO | 17/838666 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/745 (20130101) G01N 33/6845 (20130101) G01N 33/6848 (20130101) G01N 33/6854 (20130101) G01N 33/54306 (20130101) Original (OR) Class G01N 33/54313 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220381789 | Aspinwall et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona, a body corporate (Tucson, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on Behalf of the University of Arizona, a body corporate (Tucson, Arizona) |
| INVENTOR(S) | Craig A. Aspinwall (Tucson, Arizona); Zeinab Mohktari (Tucson, Arizona); Jon T. Njardarson (Tucson, Arizona); Colleen M. Janczak (Tucson, Arizona); Kevin Scott (Tucson, Arizona) |
| ABSTRACT | The present invention provides compositions and methods for determining a saccharide level in a sample. In particular, compositions and methods of the invention include a boronic acid moiety that forms a complex with a saccharide. |
| FILED | Monday, May 10, 2021 |
| APPL NO | 17/315688 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/66 (20130101) Original (OR) Class G01N 2400/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220381854 | Jaroszynski et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Florida State University Research Foundation, Inc. (Tallahassee, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jan J. Jaroszynski (Tallahassee, Florida); George Miller (Tallahassee, Florida); David Larbalestier (Tallahassee, Florida); Anca-Monia Constantinescu (Tallahassee, Florida) |
| ABSTRACT | This disclosure presents systems, devices, and methods that use magnetometers to measure large magnetic moments with strong magnetic anisotropy. A torque magnetometer may include an actuator driven by a motor, a load cell coupled to the actuator, a rotatable spool having a platform configured to hold a sample of a superconductor material, where the rotatable spool is coupled to the load cell by a first line, a pulley, and a second line extending between the rotatable spool and a counterweight, where the second line is positioned on the pulley. Movement of the actuator may cause the rotatable spool to rotate an angle of the platform relative to a magnetic field about the rotatable spool, and the load cell is capable of measuring the tension on the first line. |
| FILED | Thursday, May 26, 2022 |
| APPL NO | 17/804297 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/096 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 43/02 (20130101) H01L 43/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220381863 | Oscanoa Aida et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Julio A. Oscanoa Aida (Stanford, California); Frank Ong (Palo Alto, California); Mert Pilanci (Palo Alto, California) |
| ABSTRACT | In a method for magnetic resonance imaging pseudorandomly undersampled k- space imaging data is acquired with multiple receiver coils of an MRI imaging apparatus. MR image reconstruction is performed to produce a reconstructed MR image from the k-space imaging data by iteratively solving sketched approximations of an original reconstruction problem. The sketched approximations use a sketched model matrix As that is a lower-dimensional version of an original model matrix A of the original reconstruction problem. The sketched model matrix As preserves the Fourier structure of the MR reconstruction problem and reduces the number of coils actively used during reconstruction. |
| FILED | Friday, May 13, 2022 |
| APPL NO | 17/744299 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/543 (20130101) G01R 33/5611 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 11/006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220382574 | Gopalan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for The State University of New York (Binghamton, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kartik Gopalan (Vestal, New York); Ping Yang (Vestal, New York); Dinuni K. Fernando (Hapugoda, Sri Lanka); Jonathan Terner (Beacon, New York) |
| ABSTRACT | Post-copy is one of the two key techniques (besides pre-copy) for live migration of virtual machines in data centers. Post-copy provides deterministic total migration time and low downtime for write-intensive VMs. However, if post-copy migration fails for any reason, the migrating VM is lost because the VM's latest consistent state is split between the source and destination nodes during migration. PostCopyFT provides a new approach to recover a VM after a destination or network failure during post-copy live migration using an efficient reverse incremental checkpointing mechanism. PostCopyFT was implemented and evaluated in the KVM/QEMU platform. Experimental results show that the total migration time of post-copy remains unchanged while maintaining low failover time, downtime, and application performance overhead. |
| FILED | Monday, August 08, 2022 |
| APPL NO | 17/818234 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/45558 (20130101) Original (OR) Class G06F 11/1451 (20130101) G06F 2009/4557 (20130101) G06F 2009/45583 (20130101) G06F 2201/84 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220382851 | Chakrabartty et al. |
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| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shantanu Chakrabartty (St. Louis, Missouri); Mustafizur Rahman (St. Louis, Missouri) |
| ABSTRACT | A one-time self-powered timer circuit whose state can be measured only once, after which the timer will de-synchronize itself. In this manner, the timers can only be used for one-pad authentication. The security of the public-key distribution algorithms that will exploit the synchronization between billions of hardware-software timers, time reversibility of software timer and time irre-versibility of hardware timers and one-time read-out to deliver classical and quantum-like benefits. System-on-chip and circuit imple-mentation of the self-powered timer array, read-out, programming and initialization modules that implements the proposed public-key distribution algorithms. |
| FILED | Friday, November 06, 2020 |
| APPL NO | 17/755692 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/42 (20130101) G06F 21/44 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 9/3006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220383205 | Dillavou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Samuel Dillavou (Philadelphia, Pennsylvania); Douglas Durian (Swarthmore, Pennsylvania); Andrea J. Liu (Philadelphia, Pennsylvania); Menachem Stern (Philadelphia, Pennsylvania); Marc Z. Miskin (Media, Pennsylvania) |
| ABSTRACT | A system for physics-based learning and computation including two networks, each having a plurality of identical edges and feedback circuitry to compare the voltage drop at a given edge of the first network with the voltage drop at the corresponding edge of the second network. In both networks, at least one corresponding node is designated for input and at least one corresponding node is designated for output. In the first network, the at least one output node remains free and produces output voltage in response to the input voltage(s). In the second network, the at least one output node is clamped at voltage(s) closer to the desired value for the specified input voltage(s). Feedback circuitry compares voltages across corresponding edges and adjusts their effective resistances in order to learn. |
| FILED | Friday, May 20, 2022 |
| APPL NO | 17/750072 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 20/20 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220383478 | Catbas et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fikret Necati Catbas (Oviedo, Florida); Chuanzhi Dong (Orlando, Florida) |
| ABSTRACT | A computer vision-based system provides for load distribution estimation and load rating and vibration serviceability assessment of structures. The system integrates evaluates the structural load carrying capacity, the diagnosis and prognosis of performance and safety, and vibration serviceability. Cameras record images of a structure, and regions of interest are monitored in those images for their displacement and velocity as loading varies. Where the displacement determined exceeds a predetermined threshold, or where the acceleration determined exceeds predetermined limits, or where the distribution of displacements of parts of the structure deviates substantially from an estimated displacement distribution, an output indicating potential problems with the structure is output. |
| FILED | Friday, April 01, 2022 |
| APPL NO | 17/712038 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/0002 (20130101) Original (OR) Class G06T 7/74 (20170101) Image or Video Recognition or Understanding G06V 10/225 (20220101) Pictorial Communication, e.g Television H04N 5/247 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220383732 | TABKHIVAYGHAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University Of North Carolina At Charlotte (Charlotte, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hamed TABKHIVAYGHAN (Charlotte, North Carolina); Omidreza SHOGHLI (Charlotte, North Carolina) |
| ABSTRACT | An edge device for monitoring safety of a highway work zone is disclosed. The edge device includes at least one camera, one or more processors, and memory. The at least one camera is configured to capture images in sequence. The memory stores computer-executable instructions that, when executed, cause the one or more processors to: perform vehicle detection over an input of a data stream of the images, from the at least one camera, utilizing just-in-time processing; determine a level of safety by tracking vehicles detected and performing a time sequence analysis of the vehicles; and send a signal to one or more assisted reality devices indicating the level of safety thereto. |
| FILED | Thursday, March 03, 2022 |
| APPL NO | 17/685605 |
| CURRENT CPC | Image or Video Recognition or Understanding G06V 10/82 (20220101) G06V 20/54 (20220101) G06V 2201/08 (20220101) Traffic Control Systems G08G 1/005 (20130101) Original (OR) Class Pictorial Communication, e.g Television H04N 7/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220383976 | Veneziano et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Remi Veneziano (Allston, Massachusetts); Sakul Ratanalert (Cambridge, Massachusetts); Tyson Shepherd (Arlington, Massachusetts); Hyungmin Jun (Arlington, Massachusetts); Mark Bathe (Cambridge, Massachusetts) |
| ABSTRACT | Methods for the top-down design of nucleic acid nanostructures of arbitrary geometry based on target shape of spherical or non-spherical topology are described. The methods facilitate 3D molecular programming of lipids, proteins, sugars, and RNAs based on a DNA scaffold of arbitrary 2D or 3D shape. Geometric objects are rendered as node-edge networks of parallel nucleic acid duplexes, and a nucleic acid scaffold routed throughout the network using a spanning tree formula. Nucleic acid nanostructures produced according to top-down design methods are also described. In some embodiments, the nanostructures include single-stranded nucleic acid scaffold, DX crossovers, and staple strands. In other embodiments, the nanostructures include single-stranded nucleic acid scaffold, PX crossovers and no staples. Modified nanostructures include chemically modified nucleotides and conjugated to other molecules are described. |
| FILED | Tuesday, August 02, 2022 |
| APPL NO | 17/816883 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/26 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/10 (20130101) C12N 15/11 (20130101) C12N 2320/32 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/00 (20190201) Original (OR) Class G16B 15/10 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220384727 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA (Tuscaloosa, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dawen Li (Tuscaloosa, Alabama); Zhongliang Ouyang (Tuscaloosa, Alabama) |
| ABSTRACT | Disclosed herein are methods of annealing a perovskite layer, comprising irradiating the perovskite layer with a light source, wherein the light source is a UV light emitting diode or array of UV-LEDs for rapid and large-area exposure without scanning over the perovskite film, wherein the light source emits radiation consisting essentially of wavelengths within 50 nm of the wavelength of maximum absorbance (λmax) of the perovskite layer, thereby annealing the perovskite layer. Also disclosed herein are semiconducting devices and articles of manufacture comprising an annealed perovskite layer made by any of the methods described herein, such as solar cells, light-emitting diodes, photodetectors, thin-film transistors, laser diodes, and combinations thereof. |
| FILED | Thursday, August 04, 2022 |
| APPL NO | 17/880843 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0026 (20130101) Original (OR) Class H01L 51/0037 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220385362 | Enhos et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kerem Enhos (Boston, Massachusetts); Emrecan Demirors (Boston, Massachusetts); Tommaso Melodia (Newton, Massachusetts) |
| ABSTRACT | A visible light communication (VLC) system transmits and receives visible light signals across a VLC channel that includes an air-water interface. A transmitter may be configured generates and transmits a visible light signal across the VLC channel to a remote device, and a signal modulator controls the transmitter to generate the visible light signal from a digital transmission signal in accordance with a modulation setting. A receiver processes a remote visible light signal received across the VLC channel from the remote device. A signal demodulator converts the remote visible light signal to a received digital signal. |
| FILED | Friday, May 27, 2022 |
| APPL NO | 17/804443 |
| CURRENT CPC | Transmission H04B 10/116 (20130101) Original (OR) Class H04B 10/516 (20130101) H04B 10/676 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220385479 | HOFFSTEIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BROWN UNIVERSITY (Providence, Rhode Island); WORCESTER POLYTECHNIC INSTITUTE (Worcester, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey HOFFSTEIN (Providence, Rhode Island); Joseph SILVERMAN (Needham, Massachusetts); Berk SUNAR (Boylston, Massachusetts); Yarkin DOROZ (Worcester, Massachusetts) |
| ABSTRACT | A PQ signature scheme MMSAT that is capable of aggregating and compressing unrelated messages signed individually by different parties. The scheme extends the notion of multi-signatures, which are signatures that support aggregation of signatures on a single message signed by multiple parties. |
| FILED | Friday, September 11, 2020 |
| APPL NO | 17/642647 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/008 (20130101) H04L 9/3255 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220385484 | Behnia et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rouzbeh Behnia (Tampa, Florida); Attila Altay Yavuz (Tampa, Florida) |
| ABSTRACT | A method, system, or apparatus for generating and/or verifying a signature on a message is provided. The method, system, or apparatus at a signer may include receiving a message, generating a security parameter, generating at least two seeds corresponding to at least two servers based on the security parameter, transmitting the at least two seeds to each server of the at least two servers, determine a private key based on the security parameter or the at least two seeds, and generating, on the message, a signature based on the private key. The method, system, or apparatus at a verifier may include receiving, from a signer, a signature on a message, obtaining at least two partial public keys, determining a full public key based on the at least two partial public keys, and authenticating the signature on the message based on the full public key. Other aspects, embodiments, and features are also claimed and described. |
| FILED | Friday, May 06, 2022 |
| APPL NO | 17/739036 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/321 (20130101) H04L 9/0869 (20130101) H04L 9/3236 (20130101) H04L 9/3268 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220385798 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhiwen Liu (State College, Pennsylvania); Christine D. Keating (State College, Pennsylvania); Cheng-Yu Wang (State College, Pennsylvania); Jennifer R. Miller (University Park, Pennsylvania) |
| ABSTRACT | An imaging system includes a scattering assembly with a scattering medium positioned a first distance from an object to be imaged. The scattering medium includes a plurality of particles suspended in a suspension medium and at least one field source generating an electromagnetic field to manipulate an orientation, concentration, spatial distribution, and/or other properties of the plurality of particles. The imaging system further includes a detector including a plurality of detector elements positioned a second distance from the scattering medium and an image processing system configured to reconstruct an image of the object from an object image signal detected by the detector using object light scattered by the scattering medium and incident on the detector. |
| FILED | Friday, August 21, 2020 |
| APPL NO | 17/636078 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 5/0242 (20130101) Pictorial Communication, e.g Television H04N 5/2256 (20130101) H04N 5/2351 (20130101) H04N 5/2352 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20220378046 | Pietri |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | South Dakota Board of Regents (Pierre, South Dakota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jose Pietri (Sioux Falls, South Dakota) |
| ABSTRACT | Treatment compositions for controlling bed bugs and methods of use, including reducing bed bug resistance to a biological control agent are disclosed. The treatment compositions can include both a NF-kB signaling inhibitor and biological control agent, such as, an entomopathogenic bacteria, to improve the treatment composition efficacy against bed bugs. Provisioning of a small molecule inhibitor of NF-kB signaling can increase the rate of bed bug mortality during infection with a bacterial entomopathogen. Increased mortality can be independent of direct effects of the inhibitor on bacterial growth and can be instead the result of a reduced ability of bed bugs to clear the infection when treated with the inhibitor. |
| FILED | Wednesday, March 30, 2022 |
| APPL NO | 17/708829 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 25/006 (20130101) A01N 43/54 (20130101) Original (OR) Class A01N 63/27 (20200101) Biocidal, Pest Repellant, Pest Attractant or Plant Growth Regulatory Activity of Chemical Compounds or Preparations A01P 7/04 (20210801) A01P 19/00 (20210801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220378529 | Frederick et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tom Frederick (Lincoln, Nebraska); Eric Markvicka (Brush, Colorado); Shane Farritor (Lincoln, Nebraska); Dmitry Oleynikov (Omaha, Nebraska) |
| ABSTRACT | The embodiments disclosed herein relate to various robotic and/or in vivo medical devices having compact joint configurations. Other embodiments relate to various medical device components, including forearms having grasper or cautery end effectors, that can be incorporated into certain robotic and/or in vivo medical devices. |
| FILED | Thursday, August 04, 2022 |
| APPL NO | 17/880823 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 18/14 (20130101) A61B 18/1445 (20130101) A61B 34/30 (20160201) Original (OR) Class A61B 2018/1253 (20130101) A61B 2034/305 (20160201) A61B 2217/005 (20130101) A61B 2217/007 (20130101) Manipulators; Chambers Provided With Manipulation Devices B25J 9/046 (20130101) B25J 9/0087 (20130101) B25J 9/102 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220379235 | Glezer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ari Glezer (Atlanta, Georgia); Thomas M. Crittenden (Atlanta, Georgia); Sourabh Kumar Jha (Atlanta, Georgia); Pablo Hidalgo (Atlanta, Georgia) |
| ABSTRACT | Low Reynolds number forced convection heat transport within the fin channels enhanced by deliberate formation of unsteady, small-scale vortical motions using elastically fluttering thin-film reeds. The vortical motions substantially increase the local heat transfer coefficient at the channel walls and mixing between the wall thermal boundary layers and the cooler core flow. The flow mechanisms associated with production, advection and dissipation of these small-scale motions are investigated in a modular, high aspect ratio channel using micro-PIV, video imaging of the reed motion, and hot-wire anemometry. The global heat transfer enhancement in a modular heat sink prototype shows that the reed-induced small scale motions increase the turbulent kinetic energy of the flow even when the base flow undergoes transition to turbulence, leading to an increase in the local and global Nusselt number that is sustained at higher Re and a minor relative increase in losses. |
| FILED | Wednesday, September 23, 2020 |
| APPL NO | 17/762177 |
| CURRENT CPC | Separation B01D 5/0033 (20130101) Original (OR) Class Refrigeration Machines, Plants or Systems; Combined Heating and Refrigeration Systems; Heat-pump Systems F25B 39/04 (20130101) Refrigerators; Cold Rooms; Ice-boxes; Cooling or Freezing Apparatus Not Otherwise Provided for F25D 23/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220379792 | Wehner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Stratom, Inc. (Boulder, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ross Wehner (Boulder, Colorado); Ryan Marsini (Frederick, Colorado); Ryan Delgizzi (Arvada, Colorado); Mark Gordon (Lafayette, Colorado); Thomas Steen (Davidson, North Carolina); Jesse Weifenbach (Thornton, Colorado); Gregory Engleman (Loveland, Colorado); David Regan (Arvada, Colorado); Broc Sommermeyer (Windsor, Colorado) |
| ABSTRACT | A cargo transport system is provided that has an ability to move cargo in an autonomous or semi-autonomous manner, using a compact lift vehicle capable of lifting relatively heavy objects. The system includes a cargo loading system, a sensor suite coupled with a controller, dunnage detection, cross-decking capability, cargo stacking capability, autonomous navigation, tip detection and prevention, or any combinations thereof. The system may include a fork assembly coupled with a mast and movable in a vertical direction relative to the mast. Further, the mast may be coupled with a platform or deck and movable in a horizontal direction relative to the platform, to allow the fork assembly to be lowered below a top plane of the platform when the mast is at a forward location relative to the platform. The controller and sensor suite and may provide for autonomous or semi-autonomous control and movement of the cargo transport system. |
| FILED | Tuesday, May 24, 2022 |
| APPL NO | 17/752655 |
| CURRENT CPC | Vehicles Adapted for Load Transportation or to Transport, to Carry, or to Comprise Special Loads or Objects B60P 1/36 (20130101) Original (OR) Class Servicing, Cleaning, Repairing, Supporting, Lifting, or Manoeuvring of Vehicles, Not Otherwise Provided for B60S 9/10 (20130101) Motor Vehicles; Trailers B62D 55/065 (20130101) Hoisting, Lifting, Hauling or Pushing, Not Otherwise Provided For, e.g Devices Which Apply a Lifting or Pushing Force Directly to the Surface of a Load B66F 9/063 (20130101) B66F 9/195 (20130101) B66F 9/07559 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380023 | Takahashi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | USA as represented by the Secretary of the Army (Washington, District of Columbia) |
| ASSIGNEE(S) | USA as represented by the Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | Marc D. Takahashi (Cupertino, California); Brian T. Fujizawa (Santa Rosa, California); Jeffery A. Lusardi (Woodland, Washington) |
| ABSTRACT | This disclosure provides a means to implement an autonomous guidance and flight control system on a partial authority aircraft. One embodiment of the disclosure includes receiving a control command result, filtering the control command result into a low frequency component and a high frequency component, directing the low frequency component to at least one trim servomechanism and directing the high frequency component to at least one stability augmentation stabilizer servomechanism, linking outputs from the trim servomechanism and the stability augmentation stabilizer servomechanism for actuating a pilot control configured to control rotors, and actuating at least one rotor. The low frequency component includes frequencies below a break frequency and the high frequency component includes frequencies above the break frequency. The break frequency is established by rate and position of the at least one servomechanism. |
| FILED | Wednesday, April 13, 2022 |
| APPL NO | 17/719967 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 13/503 (20130101) Original (OR) Class Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 43/00 (20130101) Traffic Control Systems G08G 5/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380237 | Arnett et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States of America as Represented by The Secretary of the Army (Alexandria, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Clint M Arnett (Mahomet, Illinois); Martin A Page (Urbana, Illinois); Donald M Cropek (Champaign, Illinois); Ashley N Boyd (Champaign, Illinois); Justin Lange (Mahomet, Illinois) |
| ABSTRACT | A recombinant Moringa oleifera coagulant protein (MO) produced and secreted by Bacillus has coagulation/flocculation activity. The MO protein and the Bacillus host cells expressing the MO protein can be used in compositions and methods for treating contaminated water, such as drinking water or waste water. The MO protein can coagulate or flocculate suspended solid impurities in the water, which can then be removed. |
| FILED | Monday, March 21, 2022 |
| APPL NO | 17/700461 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/5263 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380409 | Heath et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James R. Heath (Pasadena, California); Rosemary Dyane Rohde (Pasadena, California); Arundhati Nag (Pasadena, California); Samir Das (Pasadena, California); Aiko Umeda (Pasadena, California) |
| ABSTRACT | Peptides having activity as protein binding agents are disclosed. The peptides have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R, R1, L1, L2, G, M, Y1 Y2 and SEQ are as defined herein. Methods associated with preparation and use of such peptides, as well as pharmaceutical compositions comprising such peptides, are also disclosed. |
| FILED | Monday, June 20, 2022 |
| APPL NO | 17/844456 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/0032 (20130101) A61K 49/0041 (20130101) A61K 49/0043 (20130101) A61K 51/08 (20130101) A61K 51/088 (20130101) Peptides C07K 1/047 (20130101) C07K 5/06 (20130101) C07K 5/08 (20130101) C07K 5/10 (20130101) C07K 7/56 (20130101) C07K 7/64 (20130101) Original (OR) Class C07K 14/001 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/573 (20130101) G01N 33/6842 (20130101) G01N 2333/912 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380414 | FINZI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CENTRE HOSPITALIER DE L'UNIVERSITÉ DE MONTRÉAL (Montreal, Canada); THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania); THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrés FINZI (St-Bruno-de-Montarville, Canada); Jérémie PRÉVOST (Mirabel, Canada); Marzena PAZGIER (Derwood, Maryland); Amos B. SMITH, III (Merion Station, Pennsylvania) |
| ABSTRACT | Compositions and methods based on the use of mutated HIV-1 gp120 polypeptides having amino acid substitutions at positions 61, 105, 108, 375, 474, 475 and 476 are described. These mutated HIV-1 gp120 polypeptides, which make the HIV env protein more amenable to adopt specific conformations when contacted with gp120 ligands, may be useful as vaccines or tools to identify and characterize agents modulating HIV infection. |
| FILED | Wednesday, September 23, 2020 |
| APPL NO | 17/762333 |
| CURRENT CPC | Heterocyclic Compounds C07D 285/14 (20130101) C07D 333/38 (20130101) Peptides C07K 14/162 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56988 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380421 | Bondy-Denomy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph Bondy-Denomy (Oakland, California); Caroline Mahendra (Oakland, California) |
| ABSTRACT | The present disclosure provides Cas9-inhibiting polypeptides and polynucleotides, and methods of using the same to inhibit Cas9 in cells. |
| FILED | Monday, May 02, 2022 |
| APPL NO | 17/734775 |
| CURRENT CPC | Peptides C07K 14/195 (20130101) C07K 14/4703 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/85 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380500 | Elder et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Delwin Elder (Seattle, Washington); Huajun Xu (Seattle, Washington); Bruce H. Robinson (Seattle, Washington); Larry R. Dalton (Seattle, Washington) |
| ABSTRACT | Crosslinked films having electro-optic activity, compositions and compounds for making the films, methods for making the films, and devices that include the films are disclosed. |
| FILED | Wednesday, July 01, 2020 |
| APPL NO | 17/624519 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 220/14 (20130101) Original (OR) Class Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/24 (20130101) C08J 5/18 (20130101) C08J 2333/12 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/3617 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380764 | Brown et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SRI International (Menlo Park, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kathlynn C. Brown (Menlo Park, California); Michael McGuire (Menlo Park, California); Shunzi Li (Menlo Park, California); Indu Venugopal (Menlo Park, California); Curtis Allred (Menlo Park, California) |
| ABSTRACT | Disclosed are compositions comprising a nucleic acid sequence conjugated to one or more MGS peptides. Disclosed are methods of modifying gene expression of a gene of interest comprising administering to a cell a composition comprising a nucleic acid sequence conjugated to one or more MGS peptides, wherein the nucleic acid sequence binds to the RNA transcribed from the gene of interest, the gene of interest or a sequence upstream of the gene of interest. Disclosed are methods of targeting a gene of interest in an intracellular target comprising administering to a cell a composition comprising a nucleic acid sequence conjugated to one or more MGS peptides, wherein the MGS peptide targets the intracellular target, wherein the nucleic acid sequence binds to the RNA transcribed from the gene interest in an intracellular target. |
| FILED | Friday, July 31, 2020 |
| APPL NO | 17/766109 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/711 (20130101) A61K 31/7105 (20130101) A61K 47/64 (20170801) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380826 | Jewett et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael C. Jewett (Evanston, Illinois); Jasmine M. Hershewe (Evanston, Illinois); Katherine F. Warfel (Evanston, Illinois) |
| ABSTRACT | Disclosed are protocols for preparing cell-free extracts preparation protocols that are enriched in membrane vesicles and use of the disclosed extract in cell-free glycoprotein synthesis methods and platforms for increasing glycoprotein yields. |
| FILED | Monday, October 26, 2020 |
| APPL NO | 17/771590 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1081 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/005 (20130101) Original (OR) Class Enzymes C12Y 204/99019 (20150701) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380893 | CHANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christina M. CHANG (Cambridge, Massachusetts); Luke M. DAVIS (Cambridge, Massachusetts); Roy Gerald GORDON (Cambridge, Massachusetts) |
| ABSTRACT | Articles are described including a substrate and a copper halide layer on the substrate, where the interfacial free energy between the substrate and the copper halide layer allows the copper halide layer to form continuously, wherein the copper halide layer conforms to the shape of the substrate. The articles may further include an adhesion layer disposed in-between the substrate and the copper halide layer, where the surface free energy between the adhesion layer and the copper halide layer allows the copper halide layer to form continuously, wherein the copper halide layer or the adhesion layer conform to the shape of the substrate. Also described are methods of forming an article using chemical vapor deposition. |
| FILED | Friday, June 12, 2020 |
| APPL NO | 17/618217 |
| CURRENT CPC | Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 3/05 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/30 (20130101) Original (OR) Class C23C 16/0272 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/4293 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380969 | Limpaecher et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); United States Marine Corps (Washington, District of Columbia) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); United States Marine Corps (Washington, District of Columbia) |
| INVENTOR(S) | Erik Limpaecher (Concord, Massachusetts); Jacob Clayton (Cambridge, Massachusetts); Douglas Baker (Cambridge, Massachusetts); William Homsby (Fort Belvoir, Virginia) |
| ABSTRACT | Devices and methods related to drying absorbent articles with water reactive materials are generally described. |
| FILED | Friday, May 28, 2021 |
| APPL NO | 17/334017 |
| CURRENT CPC | Domestic Washing or Cleaning; Suction Cleaners in General A47L 23/20 (20130101) Laundering, Drying, Ironing, Pressing or Folding Textile Articles D06F 60/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220381168 | Sperry |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cummins Inc. (Columbus, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert G. Sperry (Columbus, Indiana) |
| ABSTRACT | A storage reservoir for an internal combustion engine is provided that includes a plurality of vents connected to an air compartment that outlets air from the storage reservoir. The storage reservoir can remain vented to supply of lubrication fluid even if the internal combustion engine is inclined due to operation along severe grades. |
| FILED | Tuesday, June 01, 2021 |
| APPL NO | 17/335712 |
| CURRENT CPC | Lubricating of Machines or Engines in General; Lubricating Internal Combustion Engines; Crankcase Ventilating F01M 11/0004 (20130101) Original (OR) Class F01M 2011/0041 (20130101) F01M 2011/0066 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220381582 | Scheuerman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Jaelle P. Scheuerman (Metairie, Louisiana); Christopher J. Michael (Covington, Louisiana); Elias Z. Loup (New Orleans, Louisiana); Dina M. Acklin (New Orleans, Louisiana); Jason L. Harman (Baton Rouge, Louisiana); Brent A. Barre (Covington, Louisiana); Bradley M. Landreneau (Mandeville, Louisiana) |
| ABSTRACT | A method including receiving a request associated with one or more map views associated with a map, transmitting a first set of one or more map views, generating a display of at least one of the first set of one or more map views, receiving a user input associated with the display of the at least one of the first set of one or more map views, and receiving a message associated with the user input. The method may include deter mining a mapping context function based on the received message, the mapping context function being based on one or more user actions associated with one or more features on at least one previously accessed map, determining whether to modify a second set of one or more map views based on the mapping context function, and transmitting the second set of one or more map views. |
| FILED | Tuesday, May 24, 2022 |
| APPL NO | 17/751945 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/36 (20130101) G01C 21/3811 (20200801) G01C 21/3889 (20200801) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220381623 | Wilson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | U.S. Army Combat Capabilities Development Command, Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam A. Wilson (Columbia, Maryland); Darin J. Sharar (Silver Spring, Maryland); Gabriel L. Smith (Ellicott City, Maryland); Cory R. Knick (Troy, Ohio) |
| ABSTRACT | Sensor interconnects and supports and methods of making them utilize phonon disruptors for increased thermal resistance while maintaining acceptable electrical signal quality in materials. Phonon disruptors include, but are not limited to, structural features such as interfaces, grain boundaries, and point scattering sites, for example, that are designed to scatter heat carriers while allowing electrons to pass through the material. Some embodiments herein involve designing selected stacks of alternating or sequential material pairs within sensor interconnects. |
| FILED | Tuesday, May 11, 2021 |
| APPL NO | 17/317211 |
| CURRENT CPC | Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 7/16 (20130101) Original (OR) Class G01K 7/42 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220381705 | MAKEEV et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew MAKEEV (Dallas, Texas); Yuriy NIKISHKOV (Dallas, Texas) |
| ABSTRACT | A variable zoom X-ray CT method can significantly improve resolution for structures with large in-plane dimensions, for example to detect complex structural damage due to low-velocity impact in large thin composite laminate panels. The variable zoom method comprises emitting an X-ray beam from an X-ray source to project a region of interest (ROI) of a specimen within a field of view (FOV) onto a detector. Projections of the ROI are scanned with the detector while rotating the specimen about a rotational axis of a specimen stage and translating the specimen stage along an acquisition trajectory between the X-ray source and the detector. The acquisition trajectory specifies a source-to-object distance (SOD) between the X-ray source and the rotational axis of the specimen stage at each rotation angle of the specimen stage. A reconstruction computer reconstructs a three-dimensional volume of the specimen from the projections scanned by the detector. |
| FILED | Friday, October 09, 2020 |
| APPL NO | 17/766637 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/032 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/046 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220381950 | Alù et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Research Foundation of the City University of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrea Alù (Tenafly, New Jersey); Adam C. Overvig (Bronx, New York); Sander A. Mann (Brooklyn, New York); Ryan Nolen (New York, New York) |
| ABSTRACT | A thermal metasurface that provides a planar optical source based on thermal radiation or photoluminescence. The thermal metasurface provides dual perturbative control of both radiative and non-radiative lifetimes of a q-BIC via geometric and material perturbation of monomeric and dimeric pillars. |
| FILED | Monday, May 23, 2022 |
| APPL NO | 17/751078 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 1/002 (20130101) Original (OR) Class G02B 5/3033 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220381974 | COOLBAUGH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for The State University of New York (Albany, New York) |
| ASSIGNEE(S) | The Research Foundation for The State University of New York (Albany, New York) |
| INVENTOR(S) | Douglas COOLBAUGH (Albany, New York); Douglas LA TULIPE (Albany, New York); Gerald LEAKE (Albany, New York) |
| ABSTRACT | There is set forth herein an optoelectrical device, comprising: a substrate; an interposer dielectric stack formed on the substrate, the interposer dielectric stack including a base interposer dielectric stack, a photonics device dielectric stack, and a bond layer that integrally bonds the photonics device dielectric stack to the base interposer dielectric stack. There is set forth herein a method comprising building an interposer base structure on a first wafer having a first substrate, including fabricating a plurality of through vias in the first substrate and fabricating within an interposer base dielectric stack formed on the first substrate one or more metallization layers; and building a photonics structure on a second wafer having a second substrate, including fabricating one or more photonics devices within a photonics device dielectric stack formed on the second substrate. |
| FILED | Friday, July 29, 2022 |
| APPL NO | 17/815962 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/12 (20130101) G02B 6/43 (20130101) G02B 6/131 (20130101) G02B 6/4232 (20130101) G02B 6/12002 (20130101) Original (OR) Class G02B 6/12004 (20130101) G02B 2006/121 (20130101) G02B 2006/12038 (20130101) G02B 2006/12061 (20130101) G02B 2006/12138 (20130101) G02B 2006/12147 (20130101) G02B 2006/12176 (20130101) G02B 2006/12178 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/187 (20130101) H01L 21/486 (20130101) H01L 21/7624 (20130101) H01L 23/49838 (20130101) H01L 24/92 (20130101) H01L 27/1266 (20130101) H01L 31/02002 (20130101) H01L 31/02016 (20130101) H01L 31/02327 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220381976 | Sandhu |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gurtej Sandhu (Boise, Idaho) |
| ABSTRACT | The disclosed embodiments relate to an integrated circuit structure and methods of forming them in which photonic devices are formed on the back end of fabricating a CMOS semiconductor structure containing electronic devices. Doped regions associated with the photonic devices are formed using microwave annealing for dopant activation. |
| FILED | Friday, July 29, 2022 |
| APPL NO | 17/816336 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/12004 (20130101) Original (OR) Class G02B 2006/12061 (20130101) G02B 2006/12142 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220382557 | Walker et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dean E. Walker (Allen, Texas); Tony Brewer (Plano, Texas); Chris Baronne (Allen, Texas) |
| ABSTRACT | Devices and techniques for on-demand programmable atomic kernel loading are described herein. A programmable atomic unit (PAU) of a memory controller can receive an invocation of a programmable atomic operator by the memory controller. The PAU can then perform a verification on a programmable atomic operator partition for the programmable atomic operator. Here, the programmable atomic operator partition is located in a memory of the PAU. The PAU can then signal a trap in response to the verification indicating that the programmable atomic operator partition is not prepared. |
| FILED | Wednesday, August 03, 2022 |
| APPL NO | 17/880230 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/4403 (20130101) Original (OR) Class G06F 12/1458 (20130101) G06F 2212/1052 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220382977 | PARRISH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The MITRE Coporation (McLean, Virginia) |
| ASSIGNEE(S) | The MITRE Coporation (McLean, Virginia) |
| INVENTOR(S) | Brian PARRISH (Smithville, Missouri); Adam ZAKARIA (Cambridge, Massachusetts); Xuan CHAU (Lexington, Massachusetts); David MCCREIGHT (Vienna, Virginia); Connor SMEDLEY (Colorado Springs, Colorado); Paul BUTLER (New Smyrna Beach, Florida); Pete CARLISLE (Orlando, Florida) |
| ABSTRACT | Methods and systems are described that use artificial intelligence (AI)-based natural language processing (NLP) techniques to rapidly analyze, merge, and/or identify relationships between systems engineering artifacts (e.g., system requirements, system architecture descriptions, research requirements, risk assessments, etc.) to accelerate systems engineering program management, technical capability development, and acquisition initiatives associated with systems engineering projects. |
| FILED | Thursday, May 26, 2022 |
| APPL NO | 17/824979 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/0482 (20130101) G06F 40/279 (20200101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 5/022 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220383107 | Simons et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TELEDYNE SCIENTIFIC and IMAGING, LLC (Thousand Oaks, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen B. Simons (Raleigh, North Carolina); Mark Alan Peot (Chapel Hill, North Carolina); Thomas Stephens (Durham, North Carolina); Jon Cafaro (Raleigh, North Carolina); Ryan MacRae (Raleigh, North Carolina) |
| ABSTRACT | A method for stabilizing disrupted neural signals received by a brain-computer interface (BCI), where a translation model is trained on a clean and disrupted dataset and is used to translate a disrupted signal to a clean signal. The clean dataset is based on the data that is received the same day the BCI is calibrated and the disrupted dataset is based on data received the same day that the model is trained. Based on the variation in daily signal disruption, the training model is retrained each day and a new translation model is applied to a disrupted dataset. |
| FILED | Thursday, May 12, 2022 |
| APPL NO | 17/663031 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/015 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220383166 | GRIFFITH et al. |
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| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aaron GRIFFITH (Reynoldsburg, Ohio); Daniel GAUTHIER (Hilliard, Ohio) |
| ABSTRACT | A method of optimizing a topology for reservoir computing comprises optimizing a plurality of reservoir computer (RC) hyperparameters to generate a topology, and creating a reservoir as a network of interacting nodes with the topology. Optimizing the RC hyperparameters uses a Bayesian technique. The RC hyperparameters comprise: γ, which sets a characteristic time scale of the reservoir, σ, which determines a probability a node is connected to a reservoir input, ρin, which sets a scale of input weights, k, a recurrent in-degree of the network, and ρr, a spectral radius of the network. |
| FILED | Wednesday, September 30, 2020 |
| APPL NO | 17/765895 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 7/005 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220383524 | Menozzi et al. |
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| FUNDED BY |
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| APPLICANT(S) | Applied Research Associates, Inc. (Albuquerque, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alberico Menozzi (Raleigh, North Carolina); Chris F. Argenta (Cary, North Carolina); James B. Cook (Apex, North Carolina) |
| ABSTRACT | The described technology regards an augmented reality system and method for estimating a position of a location of interest relative to the position and orientation of a display, including receiving and selectively filtering a plurality of measurement vectors from a rate-gyroscope. Systems of the described technology include including a plurality of sensors, a processing module or other computation means, and a database. Methods of the described technology use data from the sensor package useful to accurately render graphical user interface information on a display. |
| FILED | Monday, June 06, 2022 |
| APPL NO | 17/833196 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/165 (20130101) Optical Elements, Systems, or Apparatus G02B 27/017 (20130101) G02B 27/0093 (20130101) G02B 2027/0138 (20130101) G02B 2027/0141 (20130101) G02B 2027/0181 (20130101) Electric Digital Data Processing G06F 1/163 (20130101) G06F 3/01 (20130101) G06F 3/011 (20130101) G06F 3/04817 (20130101) G06F 11/00 (20130101) Image Data Processing or Generation, in General G06T 5/20 (20130101) G06T 7/33 (20170101) Original (OR) Class G06T 11/00 (20130101) G06T 19/006 (20130101) G06T 2200/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220383764 | Bose-Pillai et al. |
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| FUNDED BY |
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| APPLICANT(S) | US Gov't as represented by Sec'y of Air Force (, None) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Santasri Bose-Pillai (Beavercreek, Ohio); Jack McRae (Bellbrook, Ohio); Christopher Rice (Cedarville, Ohio); Steven Fiorino (Beavercreek, Ohio) |
| ABSTRACT | A system and method provide improved remote turbulence measurement. The system includes an image capturing device that captures time-lapse images of a distant target anywhere from a km to more than a 100 km away. A processor of the system tracks relative motion due to atmospheric turbulence of some number of patches of definite size on each of these images using a subpixel accurate correlation technique. The processor computes differential tilt variances between every pair of patches from the image collection and evaluates the theoretical weighting functions between turbulence along the path and differential tilt variances. The processor determines weights to linearly combine the weighting functions such that the combined weighting function closely resembles the weighting function corresponding to a turbulence parameter of interest. The processor then combines the differential tilt variances using the determined weights to obtain the desired turbulence parameter. |
| FILED | Friday, March 25, 2022 |
| APPL NO | 17/704558 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/80 (20170101) G06T 2207/10048 (20130101) G06T 2207/30192 (20130101) Traffic Control Systems G08G 5/0091 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220383976 | Veneziano et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Remi Veneziano (Allston, Massachusetts); Sakul Ratanalert (Cambridge, Massachusetts); Tyson Shepherd (Arlington, Massachusetts); Hyungmin Jun (Arlington, Massachusetts); Mark Bathe (Cambridge, Massachusetts) |
| ABSTRACT | Methods for the top-down design of nucleic acid nanostructures of arbitrary geometry based on target shape of spherical or non-spherical topology are described. The methods facilitate 3D molecular programming of lipids, proteins, sugars, and RNAs based on a DNA scaffold of arbitrary 2D or 3D shape. Geometric objects are rendered as node-edge networks of parallel nucleic acid duplexes, and a nucleic acid scaffold routed throughout the network using a spanning tree formula. Nucleic acid nanostructures produced according to top-down design methods are also described. In some embodiments, the nanostructures include single-stranded nucleic acid scaffold, DX crossovers, and staple strands. In other embodiments, the nanostructures include single-stranded nucleic acid scaffold, PX crossovers and no staples. Modified nanostructures include chemically modified nucleotides and conjugated to other molecules are described. |
| FILED | Tuesday, August 02, 2022 |
| APPL NO | 17/816883 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/26 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/10 (20130101) C12N 15/11 (20130101) C12N 2320/32 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/00 (20190201) Original (OR) Class G16B 15/10 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220384043 | Poteet et al. |
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| FUNDED BY |
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| APPLICANT(S) | Lightsense Technology, Inc. (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wade Martin Poteet (Vail, Arizona); Terje A. Skotheim (Tucson, Arizona) |
| ABSTRACT | Embodiments of this invention relate generally to a method for detection of pathogens, biomarkers, or any compound using data fusion and machine learning. The method includes generating, with a first miniature UV absorption spectrometer of a multi-spectral optical device, a first absorption spectral output based on receiving an absorbance light channel from a sample, generating, with a second miniature UV fluorescence spectrometer of the multi-spectral optical device, a second emission spectral output based on receiving an emission light channel from the sample and performing, with the multi-spectral optical device, data fusion between the first absorption spectral output and the second emission spectral output to generate fused data. |
| FILED | Thursday, May 26, 2022 |
| APPL NO | 17/825983 |
| CURRENT CPC | Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220384625 | Cooper et al. |
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| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | James Albert Cooper (Santa Fe, New Mexico); Dallas Todd Morisette (Lafayette, Indiana); Madankumar Sampath (West Lafayette, Indiana) |
| ABSTRACT | A silicon carbide (SiC) metal oxide semiconductor (MOS) power device is disclosed which includes an SiC drain semiconductor region, an SiC drift semiconductor region coupled to the SiC drain semiconductor region, an SiC base semiconductor region coupled to the SiC drift semiconductor region, an SiC source semiconductor region coupled to the SiC base semiconductor region, a source electrode coupled to the SiC source semiconductor region, a drain electrode coupled to the SiC drain semiconductor region, a gate electrode, wherein voltage of the gate electrode with respect to the SiC base semiconductor region is less than or equal to about 12 V and thickness of the dielectric material is such that the electric field in the dielectric material is about 4 MV/cm when said gate voltage is about 12 V. |
| FILED | Friday, July 22, 2022 |
| APPL NO | 17/871844 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/7397 (20130101) Original (OR) Class H01L 29/7816 (20130101) Pulse Technique H03K 17/08 (20130101) H03K 17/60 (20130101) H03K 17/687 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220384833 | LI et al. |
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| FUNDED BY |
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| APPLICANT(S) | BETTERGY CORP. (PEEKSKILL, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | LIN-FENG LI (CROTON ON HUDSON, New York); SHIXUAN ZENG (CROTON ON HUDSON, New York); CAIHONG LIU (NEW CITY, New York); HYE YOUNG JUNG (CHAPPAQUA, New York) |
| ABSTRACT | Systems, methods, and membranes involving ion exchange membranes are disclosed. In an embodiment of the present invention, an ultrathin laminar layer made of inorganic nanosheets may be coated on one side or both sides of a polymeric anion exchange membrane (AEM), forming a composite AEM. Oxidation stability measurements may indicate that composite AEM provide superior oxidation resistance to exemplary polymeric AEMs and to commercial polymeric AEMs. |
| FILED | Monday, January 03, 2022 |
| APPL NO | 17/567468 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 9/19 (20210101) C25B 13/02 (20130101) C25B 13/05 (20210101) C25B 13/08 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/1053 (20130101) H01M 8/1055 (20130101) Original (OR) Class H01M 2008/1095 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220384935 | Wilson et al. |
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| FUNDED BY |
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| APPLICANT(S) | Matsing, Inc. (Irvine, California); APG Technologies, Inc. (Orange, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Stewart Wilson (Huntington Beach, California); Igor Timofeev (Dallas, Texas) |
| ABSTRACT | The inventive subject matter provides apparatus, systems and methods in which a high port count base station antenna uses an array of spherical lenses with multiple ports per frequency band, containing multiple frequency bands, and capable of multiple beam operation. In a preferred embodiment, the antenna system comprises a plurality of spherical, dielectric lenses, stacked vertically, where each lens is surrounded by four or more lower frequency radiating elements, or one circular element. The circular element can have multiple sub-elements, along with feed gaps. |
| FILED | Friday, May 28, 2021 |
| APPL NO | 17/334225 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 3/0075 (20130101) Antennas, i.e Radio Aerials H01Q 1/246 (20130101) Original (OR) Class H01Q 3/46 (20130101) H01Q 5/30 (20150115) H01Q 19/104 (20130101) H01Q 25/001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220385107 | Assawaworrarit et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sid Assawaworrarit (Redwood City, California); Shanhui Fan (Stanford, California) |
| ABSTRACT | In certain examples, methods and semiconductor structures are directed to an apparatus including source circuitry configured to provide power to other circuitry, with the source circuitry including amplification circuitry (e.g., with a power-switching output) and a source resonator. The amplification circuitry is to provide power to the source resonator with a gain that is dependent on a coupling rate between the source circuitry and other external-receiving circuitry. The source circuitry is also to offset phase delay caused by the amplifier. In operation, the source resonator generates a magnetic field in response to the power, for highly-efficient wirelessly transfer of the power to the other circuitry. |
| FILED | Friday, October 23, 2020 |
| APPL NO | 17/771296 |
| CURRENT CPC | Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 50/05 (20160201) H02J 50/12 (20160201) Original (OR) Class H02J 50/40 (20160201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220385261 | Hickle |
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| FUNDED BY |
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| APPLICANT(S) | BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| ASSIGNEE(S) | BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| INVENTOR(S) | Mark D. Hickle (Merrimack, New Hampshire) |
| ABSTRACT | Techniques are provided for a broadband microwave/millimeter-wave balanced-to-unbalanced transformer (balun). A balun implementing the techniques according to an embodiment includes a first impedance matching network configured to reduce insertion and return losses of a single-ended signal at a first port of the balun. The balun also includes a first planar bifilar coupled transmission line coupled to the first impedance matching network and configured to transform the single-ended signal into a differential signal. The balun further includes a second planar bifilar coupled transmission line coupled to the first bifilar coupled transmission line and configured to compensate for amplitude and phase imbalance induced on the differential signal by the first bifilar coupled transmission line. The balun further includes a second impedance matching network coupled to both planar bifilar coupled transmission lines and configured to reduce insertion and return losses of the differential signal at second and third ports of the balun. |
| FILED | Friday, May 28, 2021 |
| APPL NO | 17/333163 |
| CURRENT CPC | Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 5/16 (20130101) Impedance Networks, e.g Resonant Circuits; Resonators H03H 7/42 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220385276 | Doynov et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Curators of the University of Missouri (Columbia, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Plamen Doynov (Kansas City, Missouri); Anthony Caruso (Kansas City, Missouri) |
| ABSTRACT | A class of design topologies in the field of nonlinear networks (NLN) or nonlinear transmission lines (NLTL) that re-utilize direct current (DC) and low-frequency (LF) signal content reflected from a load or an output filter to yield increased pulse to radio frequency conversion efficiency and increased overall system efficiency. A nonlinear transmission line topology comprises a plurality of series inductive elements and a plurality of nonlinear capacitive elements. The inductive elements and the capacitive elements are arranged in a periodic structure forming a nonlinear network. An output coupling circuit connected across an output of the nonlinear network is configured to transmit high-frequency content to a load and to reflect back direct current and low-frequency content into the nonlinear network. |
| FILED | Tuesday, November 16, 2021 |
| APPL NO | 17/455026 |
| CURRENT CPC | Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 1/00 (20130101) Impedance Networks, e.g Resonant Circuits; Resonators H03H 11/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220385375 | Rekhi et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Angad Singh Rekhi (Stanford, California); Mohammad Amin Arbabian (Stanford, California); Chun-Ming Ernest So (Stanford, California); Albert Gural (Clifton, Virginia) |
| ABSTRACT | In some example embodiments, there is provided a tag. The tag may include an antenna configured to receive a first radio frequency signal and to reradiate a second radio frequency signal; and an ultrasonic transducer coupled to the antenna, wherein an ultrasound signal received by the ultrasonic transducer causes a variation of at least one property of the ultrasonic transducer, wherein the variation of the at least one property imparts a modulation onto at least a portion of the first radio frequency signal, and wherein the modulated first radio frequency signal is reradiated by the antenna as the second radio frequency signal. Related system, methods, and articles of manufacture are also disclosed. |
| FILED | Friday, November 13, 2020 |
| APPL NO | 17/776193 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 13/862 (20130101) G01S 13/878 (20130101) Impedance Networks, e.g Resonant Circuits; Resonators H03H 7/38 (20130101) Transmission H04B 11/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220386090 | Temkin et al. |
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| FUNDED BY |
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| APPLICANT(S) | Pleiotek (Bethesda, Maryland) |
| ASSIGNEE(S) | Pleiotek (Bethesda, Maryland) |
| INVENTOR(S) | Joshua Michael Temkin (Bethesda, Maryland); Melissa Greenfield Temkin (Bethesda, Maryland) |
| ABSTRACT | A portable data processing device for forming a wireless network includes a chamber configured within a housing; a microprocessor; a power supply; a sensor communicatively coupled to the microprocessor; and data storage media; and a wireless communication module. The microprocessor is configured to broadcast, by the wireless communication module, a device identification signal; listen for an external device identification signal; transmit device capability data; receive external device capability data. The microprocessor is further configured to receive an internal measurement from the sensor; transmit the internal measurement; receive an external measurement from the external device; analyze the internal measurement and the external measurement to determine an analysis result; and transmit the analysis result. |
| FILED | Monday, August 08, 2022 |
| APPL NO | 17/883353 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/011 (20130101) Wireless Communication Networks H04W 4/38 (20180201) Original (OR) Class H04W 4/80 (20180201) H04W 52/0261 (20130101) H04W 76/10 (20180201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220386457 | Gupte et al. |
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| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia); Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Omkar Gupte (Atlanta, Georgia); Vanessa Smet (Atlanta, Georgia); Gregorio R. Murtagian (Phoenix, Arizona) |
| ABSTRACT | An electronic device carrier structure can include a substrate including a plurality of electrical contacts spaced apart on the substrate, a plurality of electrically conductive balls, each of the electrically conductive balls being on a respective one of the plurality of electrical contacts, solder attaching each of the electrically conductive balls to respective ones of the electrical contacts to form an attachment boundary where the solder ends on a surface of each of the plurality of electrically conductive balls, and a polymer layer extending on the substrate onto the plurality of electrically conductive balls to form a surface of the polymer layer at a contact point on the plurality of electrically conductive balls that is above the attachment boundary and below an apex of each of the plurality of electrically conductive balls. |
| FILED | Saturday, May 21, 2022 |
| APPL NO | 17/664408 |
| CURRENT CPC | Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/09 (20130101) H05K 1/0296 (20130101) Original (OR) Class H05K 3/22 (20130101) H05K 2201/10734 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20220379259 | Liu et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kunlei Liu (Lexington, Kentucky); Heather Nikolic (Lexington, Kentucky); Fan Zhen (St. Clair, Michigan); Jesse Thompson (Lexington, Kentucky); Amanda Warriner (Lexington, Kentucky) |
| ABSTRACT | An apparatus includes an absorber having a first packing section, a second packing section and a third packing section. The first packing segment includes a first structured packing, having a first specific surface area SA1, the second packing segment includes a second structured packing, having a second specific surface area SA2, and the third packing segment includes a third structured packing, having a third specific surface area SA3 where SA1<SA2<SA3. The structured packing in the various packing segment may be periodically interrupted with one or more layers of random packing. |
| FILED | Monday, August 08, 2022 |
| APPL NO | 17/883482 |
| CURRENT CPC | Separation B01D 53/185 (20130101) B01D 53/1418 (20130101) B01D 53/1475 (20130101) Original (OR) Class B01D 2257/504 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220379260 | MAJUMDAR |
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| FUNDED BY |
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| APPLICANT(S) | COMPACT MEMBRANE SYSTEMS INC. (Newport, Delaware) |
| ASSIGNEE(S) | |
| INVENTOR(S) | SUDIPTO MAJUMDAR (Newark, Delaware) |
| ABSTRACT | A humidification and selective permeation module in which humidification of a gaseous feed stream and selective permeation of components in the gaseous feed stream using a facilitated-transport membrane occurs within the same unit operation is disclosed. A process for separation of components in a gaseous feed stream using the humidification and permeation module combines continuous humidification of the feed stream and selective permeation using the facilitated-transport membrane. |
| FILED | Tuesday, June 16, 2020 |
| APPL NO | 17/772247 |
| CURRENT CPC | Separation B01D 53/228 (20130101) Original (OR) Class B01D 63/02 (20130101) B01D 69/02 (20130101) B01D 2053/224 (20130101) B01D 2325/16 (20130101) B01D 2325/02833 (20220801) Acyclic or Carbocyclic Compounds C07C 7/144 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380237 | Arnett et al. |
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| FUNDED BY |
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| APPLICANT(S) | United States of America as Represented by The Secretary of the Army (Alexandria, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Clint M Arnett (Mahomet, Illinois); Martin A Page (Urbana, Illinois); Donald M Cropek (Champaign, Illinois); Ashley N Boyd (Champaign, Illinois); Justin Lange (Mahomet, Illinois) |
| ABSTRACT | A recombinant Moringa oleifera coagulant protein (MO) produced and secreted by Bacillus has coagulation/flocculation activity. The MO protein and the Bacillus host cells expressing the MO protein can be used in compositions and methods for treating contaminated water, such as drinking water or waste water. The MO protein can coagulate or flocculate suspended solid impurities in the water, which can then be removed. |
| FILED | Monday, March 21, 2022 |
| APPL NO | 17/700461 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/5263 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380265 | Sant et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gaurav Sant (Los Angeles, California); Iman Mehdipour (Los Angeles, California); Gabriel D. Falzone (Los Angeles, California) |
| ABSTRACT | Provided herein are compositions and methods of carbonation processing for the fabrication of cementitious materials and concrete products. Embodiments include manufacturing processes of a low-carbon concrete product comprising: forming a cementitious slurry including portlandite; shaping the cementitious slurry into a structural component; and exposing the structural component to a CO2 waste stream, thereby enabling manufacture of the low-carbon concrete product. |
| FILED | Wednesday, June 15, 2022 |
| APPL NO | 17/840809 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 2/02 (20130101) C04B 40/0231 (20130101) Original (OR) Class C04B 40/0263 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380412 | SAUNDERS et al. |
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| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina); Triad National Security, LLC (Los Alamos, New Mexico); The Trustees of The University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin O. SAUNDERS (Durham, North Carolina); Barton F. HAYNES (Durham, North Carolina); Bette T. KORBER (Los Alamos, New Mexico); Kshitij G. WAGH (Los Alamos, New Mexico); Beatrice H. HAHN (Philadelphia, Pennsylvania); Ronnie M. RUSSELL (Philadelphia, Pennsylvania) |
| ABSTRACT | In certain aspects the invention provides HIV-1 immunogens, including HIV-1 envelopes with optimized V2 loop for antibody induction. |
| FILED | Friday, October 23, 2020 |
| APPL NO | 17/771349 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Peptides C07K 14/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2740/16022 (20130101) C12N 2740/16034 (20130101) C12N 2740/16134 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380601 | Delcamp et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Mississippi (University, Mississippi) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jared Heath Delcamp (Oxford, Mississippi); Roberta Ramalho Rodrigues (Oxford, Mississippi); Adithya Peddapuram (Oxford, Mississippi); Hammad Arshad Cheema (Lahore, Pakistan); Christine Curiac (Oxford, Mississippi) |
| ABSTRACT | Provided herein are dyes, dye-sensitized solar cells, and sequential series multijunction dye-sensitized solar cell devices. The dyes include an electron deficient acceptor moiety, a medium electron density π-bridge moiety, and an electron rich donor moiety comprising a biaryl, a substituted biaryl, or an R1, R2, R3 substituted phenyl where each of R1, R2, and R3 independently comprises H, aryl, multiaryl, alkyl substituted aryl, alkoxy substituted aryl, alkyl substituted multiaryl, alkoxy substituted multiaryl, OR4, N(R5)2, or a combination thereof, each R4 independently comprises H, alkyl, aryl, alkyl substituted aryl, alkoxy substituted aryl, or a combination thereof; and each R5 independently comprises aryl, multiaryl, alkyl substituted aryl, alkoxy substituted aryl, alkyl substituted multiaryl, alkoxy substituted multiaryl, or a combination thereof. The solar cells include a glass substrate, a dye-sensitized active layer, and a redox shuttle. The devices include at least two dye-sensitized solar cells connected in series. |
| FILED | Wednesday, June 22, 2022 |
| APPL NO | 17/808246 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 15/065 (20130101) Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 23/0058 (20130101) Original (OR) Class Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 9/2018 (20130101) H01G 9/2059 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0064 (20130101) H01L 51/0096 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380779 | DIETRICH et al. |
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| FUNDED BY |
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| APPLICANT(S) | LYGOS, INC. (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey DIETRICH (Berkeley, California); Andrew CONLEY (Berkeley, California); Christine CARLE (Berkeley, California); Nathan MIH (Berkeley, California); Chang-ting CHEN (Berkeley, California); Shuchi DESAI (Berkeley, California); Ee-been GOH (Berkeley, California); Poh TENG (Berkeley, California) |
| ABSTRACT | Provided herein are systems and methods for the production of malonic acid or a salt thereof in recombinant host cells. |
| FILED | Monday, August 31, 2020 |
| APPL NO | 17/753249 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/16 (20130101) C12N 15/52 (20130101) Original (OR) Class Enzymes C12Y 102/01004 (20130101) C12Y 301/02004 (20130101) C12Y 401/01001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380790 | Loque et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dominique Loque (Vernier, Switzerland); Henrik Vibe Scheller (Millbrae, California) |
| ABSTRACT | The invention provides methods of engineering plants having lignin deposition or xylan deposition that is substantially localized to the vessels of xylem tissue in the plant. The invention also provides methods of engineering plants to increase production of a desired biosynthetic product, e.g., to have increased secondary cell wall deposition or increased wax/cutin accumulation. The engineered plants of the present invention have use in bioenergy production, e.g., by improving the density and the digestibility of biomass derived from the plant and to improve water usage requirements. |
| FILED | Wednesday, April 06, 2022 |
| APPL NO | 17/714931 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8255 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380811 | Church et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George M. Church (Brookline, Massachusetts); James Dicarlo (Boston, Massachusetts) |
| ABSTRACT | Methods of multiplex genome engineering in cells using Cas9 is provided which includes a cycle of steps of introducing into the cell a first foreign nucleic acid encoding one or more RNAs complementary to the target DNA and which guide the enzyme to the target DNA, wherein the one or more RNAs and the enzyme are members of a co-localization complex for the target DNA, and introducing into the cell a second foreign nucleic acid encoding one or more donor nucleic acid sequences, and wherein the cycle is repeated a desired number of times to multiplex DNA engineering in cells. |
| FILED | Friday, June 10, 2022 |
| APPL NO | 17/837089 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) C12N 15/902 (20130101) Original (OR) Class C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380868 | Ott et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa); UT-Battelle, LLC (Oak Ridge, Tennessee); University of Tennessee Research Foundation (Knoxville, Tennessee); Fok Industries, Inc. (Manitowoc, Wisconsin); Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan T. Ott (Ames, Iowa); Orlando Rios (Oak Ridge, Tennessee); Zachary C. Sims (Knoxville, Tennessee); David Weiss (Manitowoc, Wisconsin); Michael G. Kesler (Oak Ridge, Tennessee); Fanqiang Meng (Zhuhai, China PRC); Scott K. McCall (Livermore, California); Hunter B. Henderson (Livermore, California) |
| ABSTRACT | Production of a bulk Al-RE alloy body (product) using cast billets/ingots (cooling rates <100 C/s) or rapidly solidified Al-RE particulates (cooling rates 102-106° C./second) that have beneficial microstructural refinements that are further refined by subsequent consolidation to produce a consolidated bulk alloy product having excellent mechanical properties over a wide temperature range such as up to and above 230° C. |
| FILED | Wednesday, May 25, 2022 |
| APPL NO | 17/803369 |
| CURRENT CPC | Manufacture of Metal Sheets, Wire, Rods, Tubes or Profiles, Otherwise Than by Rolling; Auxiliary Operations Used in Connection With Metal-working Without Essentially Removing Material B21C 23/14 (20130101) Alloys C22C 1/026 (20130101) C22C 21/00 (20130101) Original (OR) Class Changing the Physical Structure of Non-ferrous Metals and Non-ferrous Alloys C22F 1/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380870 | Henderson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California); Eck Industries, Inc. (Manitowoc, Wisconsin); Iowa State University Research Foundation, Inc. (Ames, Iowa); University of Tennessee Research Foundation (Knoxville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hunter Bryant Henderson (Livermore, California); David Weiss (Manitowoc, Wisconsin); Ryan T. Ott (Ames, Iowa); Orlando Rios (Knoxville, Tennessee) |
| ABSTRACT | A product includes a material having aluminum and at least one rare earth element (REE). The material includes the following microstructure features: at least 1 volume % particles of a phase of an aluminum-rare earth element alloy, the particles comprise at least 5 weight % of the at least one rare earth element, the particles have an average aspect ratio less than or equal to 5, and an average interparticle spacing between the particles is less than or equal to 1 μm. A method includes forming a base material, the base material having aluminum and at least one rare earth element (REE), and working the base material to form a product. |
| FILED | Tuesday, June 01, 2021 |
| APPL NO | 17/335274 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/0011 (20130101) B22F 2301/052 (20130101) Alloys C22C 21/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380911 | Han et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhiji Han (Pasadena, California); Ruud Kortlever (Pasadena, California); Hsiang-Yun Chen (Pasadena, California); Jonas C. Peters (Pasadena, California); Theodor Agapie (Pasadena, California); Jorge A. Rosas Hernandez (Pasadena, California); Arnaud A. Thevenon (Pasadena, California) |
| ABSTRACT | A CO2 reduction system has a cathode in contact with a catholyte. The cathode includes a selectivity-determining layer on an electron conductor. The selectivity-determining layer includes a selectivity-determining component that includes a substituted heterocycle. |
| FILED | Thursday, June 09, 2022 |
| APPL NO | 17/836449 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 1/12 (20130101) Cracking Hydrocarbon Oils; Production of Liquid Hydrocarbon Mixtures, e.g by Destructive Hydrogenation, Oligomerisation, Polymerisation; Recovery of Hydrocarbon Oils From Oil-shale, Oil-sand, or Gases; Refining Mixtures Mainly Consisting of Hydrocarbons; Reforming of Naphtha; Mineral Waxes C10G 2/50 (20130101) Purifying or Modifying the Chemical Composition of Combustible Gases Containing Carbon Monoxide C10K 3/00 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 3/25 (20210101) Original (OR) Class C25B 11/051 (20210101) C25B 11/057 (20210101) C25B 11/075 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220381470 | Song et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of the University of Oklahoma (Norman, Oklahoma) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Li Song (Norman, Oklahoma); Choon Y. Tang (Norman, Oklahoma); Junke Wang (Norman, Oklahoma); Yilin Jiang (Norman, Oklahoma) |
| ABSTRACT | Heating, ventilation and air conditioning (HVAC) systems and methods of use are described. The HVAC system includes at least one internal surface temperature sensor configured to provide an interior wall surface temperature measurement. The internal surface temperature sensor is positioned on an interior surface of an external wall of the residential house. The HVAC system also includes a control system in communication over a network with the internal surface temperature sensor. The control system is configured to obtain the interior wall surface temperature measurement and apply a home heat transfer model to determine a predicted space air temperature. The home heat transfer model is based on thermal dynamics of space air and building structure using the interior wall surface temperature measurement. |
| FILED | Wednesday, May 18, 2022 |
| APPL NO | 17/747688 |
| CURRENT CPC | Air-conditioning; Air-humidification; Ventilation; Use of Air Currents for Screening F24F 11/63 (20180101) Original (OR) Class Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/042 (20130101) G05B 2219/2614 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220381719 | KLEIN, JR. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Walter Ellis KLEIN, JR. (Greybull, Wyoming) |
| ABSTRACT | The present disclosure provides methods for determining impedance of an electrochemical device by electrically connecting a variable impedance in parallel with the electrochemical device; electrically connecting a power supply to the electrochemical device, the power supply generating a power supply current; modulating a current through the variable impedance; measuring a stack current flowing through the electrochemical device; measuring, at the electrochemical device, a voltage across at least a portion of the electrochemical device; and calculating, based on the measured stack current and the measured voltage, the impedance of the electrochemical device. Systems for performing such methods are also provided. |
| FILED | Monday, May 23, 2022 |
| APPL NO | 17/750517 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/045 (20130101) Original (OR) Class Measuring Electric Variables; Measuring Magnetic Variables G01R 31/396 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220382121 | PANAS et al. |
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| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California); Bright Silicon Technologies, Inc. (San Francisco, California); General Atomics (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Matthew PANAS (Dublin, California); Robert MCHENRY (San Francisco, California); David Brent MARQUAND (San Diego, California); Eric Peter MCNAUL (San Diego, California) |
| ABSTRACT | The present disclosure relates to a coherent aperture array system for steering an optical source beam. The system may have a plurality of spaced apart, steerable emitters each being able to be mechanically aimed at a remote target location to steer portions of the source beam toward the target location. Each steerable emitter has a subaperture controllable independently of a remaining reflective surface of its associated steerable emitter, to receive and reflect a subportion of the source beam portion. The subportion forms a sense beam which is reflected toward a phase imaging system. A separate reference beam is created from the portion of the source beam travelling toward each steerable emitter. Each sense beam and each reference beam are thus associated uniquely with one of the steerable emitters. A phase imaging system is responsive to each of the reference beams and the sense beams, and determines phase differences between the portions of the source beam being transmitted from each steerable emitter. |
| FILED | Thursday, May 27, 2021 |
| APPL NO | 17/332602 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/292 (20130101) Original (OR) Class G02F 2203/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220382316 | PANAS et al. |
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| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Matthew PANAS (Dublin, California); Frederick SUN (Livermore, California) |
| ABSTRACT | The present disclosure relates to a mechanical AND-gate logic system that may make use of a first and second lever arms, a first pivot linkage coupling the lever arms, an output member, and a second pivot linkage coupling the second lever arm to the output member. The first lever arm has first and second spaced apart ends for independently receiving separate logic level 1 or logic level 0 input signals thereon, and an output end spaced apart from the first and second input ends. The output end is disposed generally equidistant from the first and second spaced apart ends. The second lever arm has an input end and an output end and can move in both pivoting and translating movements. The first pivot linkage couples the output end of the first lever arm to the input end of the second lever arm such that both the input end and the output end of the second lever arm are able to either pivot and or to translate. The second lever arm is only able to translate and apply a logic 1 level input signal to the output member, to thus generate a logic 1 level output signal, when a logic level 1 input signal is applied simultaneously to both of the first and second input ends of the first lever arm. |
| FILED | Wednesday, May 26, 2021 |
| APPL NO | 17/331107 |
| CURRENT CPC | Gearing F16H 21/02 (20130101) F16H 21/44 (20130101) Control Devices or Systems Insofar as Characterised by Mechanical Features Only G05G 11/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220383205 | Dillavou et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Samuel Dillavou (Philadelphia, Pennsylvania); Douglas Durian (Swarthmore, Pennsylvania); Andrea J. Liu (Philadelphia, Pennsylvania); Menachem Stern (Philadelphia, Pennsylvania); Marc Z. Miskin (Media, Pennsylvania) |
| ABSTRACT | A system for physics-based learning and computation including two networks, each having a plurality of identical edges and feedback circuitry to compare the voltage drop at a given edge of the first network with the voltage drop at the corresponding edge of the second network. In both networks, at least one corresponding node is designated for input and at least one corresponding node is designated for output. In the first network, the at least one output node remains free and produces output voltage in response to the input voltage(s). In the second network, the at least one output node is clamped at voltage(s) closer to the desired value for the specified input voltage(s). Feedback circuitry compares voltages across corresponding edges and adjusts their effective resistances in order to learn. |
| FILED | Friday, May 20, 2022 |
| APPL NO | 17/750072 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 20/20 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220383334 | Abramson et al. |
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| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexis Abramson (Cleveland Heights, Ohio); Roger French (Shaker Heights, Ohio); Ethan Pickering (Cleveland, Ohio); Mohammad Hossain (Cleveland, Ohio); Arash Khalilnejad (Cleveland, Ohio); Rojiar Haddadian (Cleveland, Ohio) |
| ABSTRACT | A system may provide virtual energy audits of one or more target buildings. The system may retrieve weather data and energy usage data specific to a given target building from a weather server and a utility server, respectively. The system may store predefined building characteristics corresponding to the given target building in local memory. Based on the weather data, energy usage data, and/or predefined building characteristics, the system may generate one or more building markers that characterize the energy usage and efficiency of the given target building. Building efficiency diagnostics and energy conservation prognostics may be generated based on the building markers and may be sent by the system to be displayed via a user interface of a client device. The energy conservation prognostics may include one or more energy conservation measure recommendations and corresponding predicted cost/energy savings. |
| FILED | Wednesday, July 27, 2022 |
| APPL NO | 17/815563 |
| CURRENT CPC | Electric Digital Data Processing G06F 7/24 (20130101) G06F 17/18 (20130101) Computer Systems Based on Specific Computational Models G06N 5/04 (20130101) G06N 5/027 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/06315 (20130101) G06Q 30/018 (20130101) Original (OR) Class G06Q 50/163 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 90/82 (20151101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220383541 | Al Rashdan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Energy Alliance, LlC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ahmad Y. Al Rashdan (Ammon, Idaho); Michael L. Wheeler (Greenwood, Indiana); Roger Lew (Moscow, Idaho); Dakota Roberson (Shelley, Idaho); Lloyd M. Griffel (Idaho Falls, Idaho); Roger Boza (Miami, Florida); Michael W. Thompson (Bokeelia, Florida) |
| ABSTRACT | Various embodiments relate to unmanned vehicle navigation. A navigation system may include one or more processors configured to communicatively couple with an unmanned vehicle. The one or more processors may be configured to receive an image from the unmanned vehicle and detect a feature within the image. The one or more processors may be further be configured to determine a location of the unmanned vehicle based on the feature and convey one or more commands to the unmanned vehicle based on the location of the unmanned vehicle. Associated methods and computer-readable medium are also disclosed. |
| FILED | Friday, November 13, 2020 |
| APPL NO | 17/755878 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 39/024 (20130101) B64C 2201/127 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/101 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 7/1413 (20130101) G06K 7/1417 (20130101) Image Data Processing or Generation, in General G06T 7/50 (20170101) G06T 7/73 (20170101) Original (OR) Class G06T 2207/10032 (20130101) G06T 2207/20081 (20130101) G06T 2207/30204 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220384074 | Hu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hong Hu (Bothell, Washington); Matthew Kasa (New Lenox, Illinois); Ethan Anliker (Oswego, Illinois); Yury Ivanyushenkov (Darien, Illinois); Yuko Shiroyanagi (Darien, Illinois); Ibrahim Kesgin (Naperville, Illinois); Quentin B. Hasse (Oswego, Illinois) |
| ABSTRACT | Superconducting undulators (SCUs) require thermal control of large heat loads for proper operation and to provide high radiation output powers. A conduction cooling apparatus for an SCU device includes a beam chamber having a hollow core inside of the beam chamber along a length of the beam chamber. The hollow core allows charged particles to pass through the hollow core of the beam chamber to generate output radiation. A beam chamber holder is physically and thermally coupled to the beam chamber to maintain a position, and control a temperature of, the beam chamber. At least one magnet is configured to provide a magnetic field to the hollow core, and at least one cooling bar is physically and thermally coupled to the magnet. A cooling source is thermally coupled to both the beam chamber holder and the cooling bar to provide cooling capacity to the beam chamber and the magnet. |
| FILED | Thursday, May 27, 2021 |
| APPL NO | 17/332633 |
| CURRENT CPC | Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 6/04 (20130101) Original (OR) Class Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/0903 (20130101) Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 7/04 (20130101) H05H 2007/041 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220384833 | LI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BETTERGY CORP. (PEEKSKILL, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | LIN-FENG LI (CROTON ON HUDSON, New York); SHIXUAN ZENG (CROTON ON HUDSON, New York); CAIHONG LIU (NEW CITY, New York); HYE YOUNG JUNG (CHAPPAQUA, New York) |
| ABSTRACT | Systems, methods, and membranes involving ion exchange membranes are disclosed. In an embodiment of the present invention, an ultrathin laminar layer made of inorganic nanosheets may be coated on one side or both sides of a polymeric anion exchange membrane (AEM), forming a composite AEM. Oxidation stability measurements may indicate that composite AEM provide superior oxidation resistance to exemplary polymeric AEMs and to commercial polymeric AEMs. |
| FILED | Monday, January 03, 2022 |
| APPL NO | 17/567468 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 9/19 (20210101) C25B 13/02 (20130101) C25B 13/05 (20210101) C25B 13/08 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/1053 (20130101) H01M 8/1055 (20130101) Original (OR) Class H01M 2008/1095 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220384856 | YADAV et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gautam G. YADAV (New York, New York); Xia WEI (New York, New York); Michael NYCE (New York, New York); Sanjoy BANERJEE (New York, New York) |
| ABSTRACT | A battery includes a housing, an electrolyte disposed in the housing, an anode disposed in the housing, and an electrode disposed in the housing and comprising an electrode material comprising manganese dioxide, and a conductive carbon coated with a metallic layer. The use of the conductive carbon coated with the metallic layer can help to control the effects of other ions such as zincate on the manganese dioxide during discharge or cycling of the battery. |
| FILED | Friday, October 30, 2020 |
| APPL NO | 17/772577 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/74 (20130101) H01M 4/364 (20130101) H01M 4/366 (20130101) H01M 4/0404 (20130101) H01M 4/485 (20130101) H01M 4/505 (20130101) H01M 4/583 (20130101) H01M 4/623 (20130101) H01M 4/662 (20130101) H01M 10/26 (20130101) Original (OR) Class H01M 2004/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220385081 | Yu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wensong Yu (Raleigh, North Carolina); Dakai Wang (Raleigh, North Carolina); Srdjan Miodrag Lukic (Raleigh, North Carolina) |
| ABSTRACT | Various examples are provided for high voltage isolation. The isolation can be provided for discrete non-isolated devices using an electrically isolating substrate that is thermally conductive. In one example, a module includes a plurality of switching devices connected in series; one or more rubber buffer disposed between switching device pairs of the plurality of switching devices; and thermal interfaces disposed between switching devices of the switching device pairs and cooling surfaces of the module, the thermal interfaces electrically isolating the switching devices from the cooling surface. In another example, an extreme fast charger (EFC) station includes an active front end (AFE) module that includes at least one module, where the module is a half-bridge power module. The EFC station can include a dual-active-bridge (DAB) high voltage (HV) module that includes at least one module, where the module is a half-bridge power module. |
| FILED | Tuesday, May 31, 2022 |
| APPL NO | 17/828477 |
| CURRENT CPC | Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 7/0042 (20130101) Original (OR) Class H02J 7/00309 (20200101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 7/209 (20130101) H05K 7/20409 (20130101) H05K 7/20481 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220385115 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battetle Energy Alliance, LLC (ldaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bo Zhang (Salt Lake City, Utah); Richard W. Carlson (Rigby, Idaho) |
| ABSTRACT | Electromagnetic shields, vehicles, wireless charging systems, and related methods are disclosed. An electromagnetic shield includes a shield member including a coil side to face one or more inductive coils. The electromagnetic shield also includes one or more perimeter shield members configured in a loop proximate to a perimeter of the coil side of the shield member. The shield member and the one or more perimeter shield members are configured to shield electromagnetic radiation emitted by the one or more inductive coils. |
| FILED | Thursday, September 03, 2020 |
| APPL NO | 17/753536 |
| CURRENT CPC | Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 53/12 (20190201) B60L 53/30 (20190201) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 27/36 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 50/005 (20200101) H02J 50/10 (20160201) H02J 50/40 (20160201) H02J 50/70 (20160201) Original (OR) Class H02J 2310/48 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220385193 | Lai et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (Blacksburg, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jih-Sheng Lai (Blacksburg, Virginia); Chih-Shen Yeh (Blacksburg, Virginia) |
| ABSTRACT | Aspects of hybrid modulation control for DC-to-AC converters are described. In one embodiment, a hybrid modulation pattern is generated. The hybrid modulation pattern separates switch gating control into multiple control regions for a half cycle of the waveform. A first control region modulates according to a first modulation technique and a second control region modulates according to a second modulation technique. The switches of a resonant converter are controlled according to the hybrid modulation pattern to generate the waveform. |
| FILED | Wednesday, September 30, 2020 |
| APPL NO | 17/765611 |
| CURRENT CPC | Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/08 (20130101) H02M 1/0058 (20210501) H02M 3/01 (20210501) H02M 3/33573 (20210501) Original (OR) Class H02M 3/33576 (20130101) H02M 7/5387 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220386509 | Zhou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TOYOTA MOTOR ENGINEERING and MANUFACTURING NORTH AMERICA, INC. (PLANO, Texas); University of Colorado Boulder (Boulder, Colorado) |
| ASSIGNEE(S) | TOYOTA MOTOR ENGINEERING and MANUFACTURING NORTH AMERICA, INC. (PLANO, Texas); University of Colorado Boulder (Boulder, Colorado) |
| INVENTOR(S) | Feng Zhou (Ann Arbor, Michigan); Yuqing Zhou (Ann Arbor, Michigan); Ercan Mehmet Dede (Ann Arbor, Michigan); Robert Erickson (Boulder, Colorado); Dragan Maksimovic (Boulder, Colorado); Vivek Sankaranarayanan (Boulder, Colorado); Yucheng Gao (Boulder, Colorado) |
| ABSTRACT | A double-sided cold plate includes a manifold comprising openings extending from a first surface of the manifold through the manifold to a second surface of the manifold forming recesses within the manifold and an inlet channel and an outlet channel fluidly coupled to the recesses within the manifold, a plurality of first heat sinks coupled to the first surface of the manifold enclosing the openings on the first surface, and a plurality of second heat sinks positioned adjacent each other along a length of the manifold and coupled to the second surface of the manifold, enclosing the openings on the second surface, a width of the plurality of second heat sinks is greater than a width of the manifold thereby forming an overhanging portion on each lengthwise side of the manifold, the overhanging portion configured to mechanically support a plurality of electrical components positioned around a perimeter of the manifold. |
| FILED | Tuesday, May 25, 2021 |
| APPL NO | 17/329727 |
| CURRENT CPC | Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 7/209 (20130101) H05K 7/20509 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20220378363 | Lu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); Trustees of Boston University (Boston, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); Trustees of Boston University (Boston, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Timothy Kuan-Ta Lu (Cambridge, Massachusetts); Rabia Tugce Yazicigil Kirby (Newton, Massachusetts); Carlo Giovanni Traverso (Newton, Massachusetts); Jenna Ahn (Stanford, California); Maria Eugenia Inda (Cambridge, Massachusetts); Miguel Jimenez (Malden, Massachusetts); Qijun Liu (Allston, Massachusetts); Phillip Nadeau (Cambridge, Massachusetts); Christoph Winfried Johannes Steiger (Berlin, Germany); Adam Wentworth (East Boston, Massachusetts) |
| ABSTRACT | Transient molecules in the gastrointestinal (GI) tract, such as nitric oxide and hydrogen sulfide, are important signals and mediators of inflammatory bowel disease (IBD). Because these molecules may be short-lived in the body, they are difficult to detect. To track these reactive molecules in the GI tract, a miniaturized device has been developed that integrates genetically engineered probiotic biosensors with a custom-designed photodetector and readout chip. Leveraging the molecular specificity of living sensors, bacteria were genetically encoded to respond to IBD-associated molecules by luminescing. Low-power electronic readout circuits (e.g., using nanowatt power) integrated into the device convert the light from just 1 μL of bacterial culture into a wireless signal. Biosensor monitoring was demonstrated in the GI tract of small and large animal models and integration of all components into a sub-1.4 cm3 ingestible form factor capable of supporting wireless communication. The wireless detection of short-lived, disease-associated molecules may support earlier diagnosis of disease than is currently possible, more accurate tracking of disease progression, and more timely communication between patient and their care team supporting remote personalized care. |
| FILED | Tuesday, April 26, 2022 |
| APPL NO | 17/730075 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/1459 (20130101) A61B 5/4255 (20130101) Original (OR) Class A61B 5/6861 (20130101) A61B 5/14507 (20130101) A61B 5/14546 (20130101) A61B 2560/04 (20130101) A61B 2562/028 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6897 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220378529 | Frederick et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tom Frederick (Lincoln, Nebraska); Eric Markvicka (Brush, Colorado); Shane Farritor (Lincoln, Nebraska); Dmitry Oleynikov (Omaha, Nebraska) |
| ABSTRACT | The embodiments disclosed herein relate to various robotic and/or in vivo medical devices having compact joint configurations. Other embodiments relate to various medical device components, including forearms having grasper or cautery end effectors, that can be incorporated into certain robotic and/or in vivo medical devices. |
| FILED | Thursday, August 04, 2022 |
| APPL NO | 17/880823 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 18/14 (20130101) A61B 18/1445 (20130101) A61B 34/30 (20160201) Original (OR) Class A61B 2018/1253 (20130101) A61B 2034/305 (20160201) A61B 2217/005 (20130101) A61B 2217/007 (20130101) Manipulators; Chambers Provided With Manipulation Devices B25J 9/046 (20130101) B25J 9/0087 (20130101) B25J 9/102 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220379252 | Cognata et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Paragon Space Development Corporation (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas Cognata (Houston, Texas); Brittany Lynn Zimmerman (Tucson, Arizona) |
| ABSTRACT | This disclosure provides a two-phase separator device for separating condensate or particulate from a gas stream. In some implementations, the separator device removes water from air and may operate under micro-gravity conditions. The gas stream flows through the two-phase separator device and passes through a rotatable vane assembly along a flow path without being redirected in another flow path. Condensate or particulate in the gas stream is impacted by a plurality of vanes of the rotatable vane assembly, and the condensate is captured by features formed within the plurality of vanes. The captured condensate is accelerated radially outwardly along the each of the plurality of vanes towards a sloped inner wall, and further moved along the sloped inner wall in a direction against the flow path of the gas stream during rotation. |
| FILED | Tuesday, August 02, 2022 |
| APPL NO | 17/816863 |
| CURRENT CPC | Separation B01D 45/04 (20130101) B01D 45/14 (20130101) Original (OR) Class B01D 45/18 (20130101) B01D 47/06 (20130101) B01D 50/40 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380060 | Burt |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States of America as representedby the Administrator of NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan M. Burt (Cleveland, Ohio) |
| ABSTRACT | An engine exhaust nozzle for a jet engine offers a controllable variable mixing of engine exhaust and the surrounding airflow. The engine exhaust nozzle includes a nozzle, slots at the downstream end of the nozzle, curved vanes extending radially inward from the inner surface of the nozzle and adjacent to the slots, and a cover connected to the outside of the nozzle and movable with respect to the nozzle so as to open and close the slots. When the slots are opened, near-field mixing is enhanced between the jet exhaust and the surrounding air, thus reducing mixing further downstream and the noise associated therewith, thus reducing the overall noise transmitted to the ground. When the slots are closed, the nozzle propulsive efficiency improves at the expense of increased noise. |
| FILED | Tuesday, May 31, 2022 |
| APPL NO | 17/804636 |
| CURRENT CPC | Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 33/06 (20130101) Original (OR) Class Jet-propulsion Plants F02K 1/386 (20130101) F02K 1/827 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20220379486 | Fry |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Mark A. Fry (Marco Island, Florida) |
| ABSTRACT | Systems and methods are described, and an example system includes a transport bin configured to carry a baggage item and having spatial reference frame marking detectable by electromagnetic scan and by machine vision. The system includes a robotic arm apparatus at an inspection area, and includes a switched path baggage conveyor that, responsive to electromagnetic scan detection of an object-of-interest (OOI) within the baggage item, conveys the transport bin to the inspection area. The electromagnetic scan generates OOI geometric position information indicating geometric position of the OOI relative to the spatial reference frame marking. The robotic arm apparatus, responsive to receiving the transport bin, uses machine vision to detect orientation of the spatial reference frame marking, then translates OOI geometric position information to local reference frame, for robotic opening of the baggage item, and robotic accessing and contact swab testing on the OOI. |
| FILED | Tuesday, August 09, 2022 |
| APPL NO | 17/884318 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/043 (20130101) B25J 9/1612 (20130101) B25J 9/1697 (20130101) Original (OR) Class B25J 13/087 (20130101) B25J 19/023 (20130101) B25J 19/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220381941 | Fortune et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | John Fortune (Clifton, Virginia); Brian Lewis (Washington, District of Columbia); Michelle Weinberger (Fairfax, Virginia); Frank Cartwright (Rockville, Maryland) |
| ABSTRACT | A method includes receiving distributed sensing information on one or more characteristics associated with a subject from sensors distributed between a starting location spaced from a resolution location and the resolution location, the resolution location including a targeted screening area, the characteristics being obtained from the sensors observing a plurality of candidate subjects including the subject; determining, based on the information on the characteristics, which category of a plurality of categories is to be associated with the subject for a targeted screening process to be performed in which respective categories correspond to different thresholds applied in the targeted screening process; and electronically communicating information for the category associated with the subject to an electronic device, to direct the subject to a location of the targeted screening area which corresponds to the category, for performing the targeted screening process of the subject corresponding to a threshold associated with the category. |
| FILED | Tuesday, April 26, 2022 |
| APPL NO | 17/729763 |
| CURRENT CPC | Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags G01V 5/0016 (20130101) Original (OR) Class Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 50/265 (20130101) Image or Video Recognition or Understanding G06V 20/52 (20220101) G06V 2201/05 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220383438 | Vemury |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Arun Vemury (North Bethesda, Maryland) |
| ABSTRACT | Embodiments are described in which information from multiple devices is merged through the exchange of linking information. For example, a two dimensional barcode is used associate information originating from different devices. In embodiments, information is associated with various levels of trust based on a variety of factors to quantify whether or not and to what extent collected information can be relied upon to be accurate. In embodiments, information from multiple sources is merged into a common transaction record that can be accessed through use of the linking information so the information can be efficiently retrieved even though it originated, or was captured, by different devices. |
| FILED | Thursday, February 03, 2022 |
| APPL NO | 17/592218 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/22 (20190101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 7/1095 (20130101) G06K 19/06037 (20130101) G06K 19/06112 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 50/30 (20130101) G06Q 50/265 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20220378711 | Banerjee et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sushanta K. Banerjee (Kansas City, Missouri); Snigdha Banerjee (Kansas City, Missouri); Mohiuddin Quadir (Fargo, North Dakota); Priyanka Ray (Fargo, North Dakota) |
| ABSTRACT | Disclosed are nanoparticles comprising a polymer carrier formed from a poly(ethylene glycol) and a poly(carbonate) copolymer which encapsulates a cargo entity such as an ERK inhibitor and/or chemotherapeutic agent. Therapeutic uses of the nanoparticles are also described, including methods of treating a cancer such as pancreatic cancer. |
| FILED | Tuesday, November 23, 2021 |
| APPL NO | 17/534427 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/4816 (20130101) A61K 9/5123 (20130101) Original (OR) Class A61K 31/506 (20130101) A61K 31/7068 (20130101) A61K 47/42 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380298 | Rettig et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); The United States Government represented by the Department of Veteran Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Rettig (Los Angeles, California); Michael E. Jung (Los Angeles, California); D. Elshan Nakath G. Ralalage (Los Angeles, California); Jiabin An (Los Angeles, California) |
| ABSTRACT | The present disclosure provides compounds and methods for inhibiting or degrading the N-terminal domain of the androgen receptor, as well as methods for treating cancers such as prostate cancer. |
| FILED | Thursday, January 13, 2022 |
| APPL NO | 17/575027 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Acyclic or Carbocyclic Compounds C07C 33/486 (20130101) C07C 49/223 (20130101) C07C 225/16 (20130101) Original (OR) Class C07C 235/34 (20130101) C07C 235/78 (20130101) C07C 321/20 (20130101) Heterocyclic Compounds C07D 207/08 (20130101) C07D 211/32 (20130101) C07D 241/04 (20130101) C07D 265/30 (20130101) C07D 303/32 (20130101) C07D 303/40 (20130101) C07D 307/52 (20130101) C07D 333/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220380332 | Uhl et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George Richard Uhl (Albuquerque, New Mexico); Ian M. Henderson (Sandia Park, New Mexico); Wei Wang (Tucson, Arizona); Thomas Prisinzano (Lexington, Kentucky) |
| ABSTRACT | Disclosed are small molecule PTPRD inhibitors and uses thereof. Methods of using the PTPRD inhibitors include methods of treating, preventing, or delaying the progression of a disorder responsive to PTPRD inhibition, including for example nicotine dependence, addiction, obesity, metabolic syndrome, and substance-use disorders such as stimulant-use disorders and opioid-use disorders. |
| FILED | Monday, May 02, 2022 |
| APPL NO | 17/734897 |
| CURRENT CPC | Heterocyclic Compounds C07D 311/54 (20130101) Original (OR) Class C07D 405/12 (20130101) C07D 409/12 (20130101) C07D 417/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20220378713 | Hsieh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents Of The University Of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | You-Lo Hsieh (Oakland, California); Xingchen Chen (Oakland, California) |
| ABSTRACT | The present invention provides compositions of soy protein gel fibers, soy protein fiber membranes, and soy protein films. The present invention also provides methods of making the soy protein compositions and also uses of the compositions. |
| FILED | Thursday, October 01, 2020 |
| APPL NO | 17/765386 |
| CURRENT CPC | Edible Oils or Fats, e.g Margarines, Shortenings, Cooking Oils A23D 7/0053 (20130101) Protein Compositions for Foodstuffs; Working-up Proteins for Foodstuffs; Phosphatide Compositions for Foodstuffs A23J 3/16 (20130101) A23J 3/28 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/7007 (20130101) Original (OR) Class A61K 31/5415 (20130101) A61K 47/42 (20130101) Separation B01D 67/0004 (20130101) B01D 67/0083 (20130101) B01D 71/74 (20130101) B01D 2323/12 (20130101) B01D 2323/39 (20130101) B01D 2323/081 (20220801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20220380043 | Mulligan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HYDRONALIX, INC. (Green Valley, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anthony C. Mulligan (Sahuarita, Arizona); Jaime Lara-Martinez (Tucson, Arizona); Drey Platt (Sahuarita, Arizona); Dylan Gutierrez (Tucson, Arizona); Eva Huie (Tucson, Arizona) |
| ABSTRACT | An unmanned aerial system includes an unmanned aerial vehicle having a body and a primary propulsion system coupled to the body. The primary propulsion system includes at least one propeller and at least one motor coupled to the at least one propeller. The unmanned aerial system also includes a pair of landing gears coupled to the body of the unmanned aerial vehicle. Each landing gear of the pair of landing gears includes a buoyant elongated float. The unmanned aerial system also includes a SONAR device coupled to the unmanned aerial vehicle. |
| FILED | Tuesday, May 25, 2021 |
| APPL NO | 17/329965 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 39/024 (20130101) Original (OR) Class B64C 2201/123 (20130101) B64C 2201/127 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 47/08 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 15/8902 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 20220383758 | BAKER, JR. et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The MITRE Corporation (McLean, Virginia) |
| ASSIGNEE(S) | The MITRE Corporation (McLean, Virginia) |
| INVENTOR(S) | David E. BAKER, JR. (Westford, Massachusetts); John A. MAURER (Burlington, Massachusetts) |
| ABSTRACT | Presented herein are systems and methods for simulating translated aircraft terminal procedures and comparing them to detect for errors in the translation of the terminal procedures. In one or more examples, one or more regulatory agency's routes and procedures for a given airspace are translated into one or more instructions that can be read by a flight computer that is configured to assist a pilot during a flight to adhere to those agency's procedures. A given terminal procedure can have multiple translations associated with it. In order to determine the accuracy of the translation process, in one or more examples, the translations provided by those vendors can be simulated by a computer that is configured to simulate an aircraft's traversal of an airspace using the instructions loaded on to the flight computer. The data generated by the simulations can be used to compare the translations to detect errors in the translation process. |
| FILED | Tuesday, June 01, 2021 |
| APPL NO | 17/335949 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/28 (20130101) Electric Digital Data Processing G06F 30/20 (20200101) Traffic Control Systems G08G 5/0017 (20130101) G08G 5/0039 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Non-Profit Organization (NPO)
| US 20220383976 | Veneziano et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Remi Veneziano (Allston, Massachusetts); Sakul Ratanalert (Cambridge, Massachusetts); Tyson Shepherd (Arlington, Massachusetts); Hyungmin Jun (Arlington, Massachusetts); Mark Bathe (Cambridge, Massachusetts) |
| ABSTRACT | Methods for the top-down design of nucleic acid nanostructures of arbitrary geometry based on target shape of spherical or non-spherical topology are described. The methods facilitate 3D molecular programming of lipids, proteins, sugars, and RNAs based on a DNA scaffold of arbitrary 2D or 3D shape. Geometric objects are rendered as node-edge networks of parallel nucleic acid duplexes, and a nucleic acid scaffold routed throughout the network using a spanning tree formula. Nucleic acid nanostructures produced according to top-down design methods are also described. In some embodiments, the nanostructures include single-stranded nucleic acid scaffold, DX crossovers, and staple strands. In other embodiments, the nanostructures include single-stranded nucleic acid scaffold, PX crossovers and no staples. Modified nanostructures include chemically modified nucleotides and conjugated to other molecules are described. |
| FILED | Tuesday, August 02, 2022 |
| APPL NO | 17/816883 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/26 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/10 (20130101) C12N 15/11 (20130101) C12N 2320/32 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/00 (20190201) Original (OR) Class G16B 15/10 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20220379792 | Wehner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Stratom, Inc. (Boulder, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ross Wehner (Boulder, Colorado); Ryan Marsini (Frederick, Colorado); Ryan Delgizzi (Arvada, Colorado); Mark Gordon (Lafayette, Colorado); Thomas Steen (Davidson, North Carolina); Jesse Weifenbach (Thornton, Colorado); Gregory Engleman (Loveland, Colorado); David Regan (Arvada, Colorado); Broc Sommermeyer (Windsor, Colorado) |
| ABSTRACT | A cargo transport system is provided that has an ability to move cargo in an autonomous or semi-autonomous manner, using a compact lift vehicle capable of lifting relatively heavy objects. The system includes a cargo loading system, a sensor suite coupled with a controller, dunnage detection, cross-decking capability, cargo stacking capability, autonomous navigation, tip detection and prevention, or any combinations thereof. The system may include a fork assembly coupled with a mast and movable in a vertical direction relative to the mast. Further, the mast may be coupled with a platform or deck and movable in a horizontal direction relative to the platform, to allow the fork assembly to be lowered below a top plane of the platform when the mast is at a forward location relative to the platform. The controller and sensor suite and may provide for autonomous or semi-autonomous control and movement of the cargo transport system. |
| FILED | Tuesday, May 24, 2022 |
| APPL NO | 17/752655 |
| CURRENT CPC | Vehicles Adapted for Load Transportation or to Transport, to Carry, or to Comprise Special Loads or Objects B60P 1/36 (20130101) Original (OR) Class Servicing, Cleaning, Repairing, Supporting, Lifting, or Manoeuvring of Vehicles, Not Otherwise Provided for B60S 9/10 (20130101) Motor Vehicles; Trailers B62D 55/065 (20130101) Hoisting, Lifting, Hauling or Pushing, Not Otherwise Provided For, e.g Devices Which Apply a Lifting or Pushing Force Directly to the Surface of a Load B66F 9/063 (20130101) B66F 9/195 (20130101) B66F 9/07559 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20220381320 | Hoffman |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BAE SYSTEMS Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| ASSIGNEE(S) | BAE SYSTEMS Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| INVENTOR(S) | Jonathan E. Hoffman (Nashua, New Hampshire) |
| ABSTRACT | An isolator, the isolator comprising an isolator comprising a lower isolator post and an upper isolator post; an isolator compression disk configured to be secured to the upper isolator post; and at least three gaskets configured to be retained, in use, between an upper face of the isolator and a lower face of the isolator compression disk, wherein the lower isolator post, in use, is configured to be affixed to a first apparatus, wherein the upper isolator post is configured to be inserted through an aperture of a second apparatus, wherein the isolator compression disk is configured to retain the second apparatus against the isolator, and wherein the at least three gaskets are configured to prevent any direct contact between the isolator and the second apparatus. |
| FILED | Wednesday, May 26, 2021 |
| APPL NO | 17/330748 |
| CURRENT CPC | Springs; Shock-absorbers; Means for Damping Vibration F16F 15/08 (20130101) Original (OR) Class Frames, Casings or Beds of Engines, Machines or Apparatus, Not Specific to Engines, Machines or Apparatus Provided for Elsewhere; Stands; Supports F16M 13/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220384988 | Feng et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Siemens Aktiengesellschaft (München, Germany) |
| ASSIGNEE(S) | Siemens Aktiengesellschaft (München, Germany) |
| INVENTOR(S) | Hai Qiao Feng (Nanjing, China PRC); Xiao Hui Zhang (Nanjing, China PRC); Guo Qing Huang (Nanjing, China PRC); Jian Wen Yang (Nanjing, China PRC); Wen Qi Zhang (Nanjing, China PRC); Qi Wu (Nanjing, China PRC); Qing Song Tang (Nanjing, China PRC); Yi Yin Yao (Nanjing, China PRC) |
| ABSTRACT | Various embodiments of the teachings herein include a signal cable connection device comprising: a cable with a sleeve and multiple loose wires extending out from an extremity of the sleeve; a conductive metal ring crimped at the extremity so the ring and the sleeve are fixed to each other, one end of the conductive metal ring having an outward-turned flange, and a shielding wire connected to the conductive metal ring; and a housing with a cable channel defining an outer opening located at an outer side of the housing and an inner opening located at an inner side of the housing, and a threaded hole at an edge of the inner opening. When a screw is screwed into the threaded hole, the outward-turned flange of the conductive metal ring is clamped between a head of the screw and a sidewall of the inner opening. |
| FILED | Friday, October 16, 2020 |
| APPL NO | 17/770473 |
| CURRENT CPC | Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors H01R 13/5205 (20130101) H01R 13/5808 (20130101) Original (OR) Class H01R 13/5816 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
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Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, December 01, 2022.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20221201.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page