FedInvent™ Patent Applications
Application Details for Thursday, December 22, 2022
This page was updated on Sunday, December 25, 2022 at 06:00 PM GMT
Department of Health and Human Services (HHS)
| US 20220400686 | Song et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jie Song (Shrewsbury, Massachusetts); Ananta Ghimire (Shrewsbury, Massachusetts) |
| ABSTRACT | The invention provides novel compounds and polymers, degradable hydrogel compositions, medical devices and implants, as well as methods thereof, that allow on-demand release and controlled delivery of antimicrobial agents. |
| FILED | Tuesday, November 24, 2020 |
| APPL NO | 17/777386 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 25/10 (20130101) A01N 63/50 (20200101) Original (OR) Class Biocidal, Pest Repellant, Pest Attractant or Plant Growth Regulatory Activity of Chemical Compounds or Preparations A01P 1/00 (20210801) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/06 (20130101) A61L 27/34 (20130101) A61L 27/52 (20130101) A61L 27/54 (20130101) A61L 2300/404 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220400732 | Goncalves et al. |
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| APPLICANT(S) | Cornell University (Ithaca, New York) |
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| INVENTOR(S) | Marcus Goncalves (Garden City, New York); Lewis C. Cantley (Cambridge, Massachusetts); Jihye Yun (Houston, Texas) |
| ABSTRACT | As described herein ingestion of high amounts of sugar, especially fructose, can increase the growth of intestinal tumors. Such cancer growth can be inhibited or prevented by limiting the amounts of sugar and amino acids ingested, by inhibiting ketohexokinase (KHK), fructose transport (via GLUT5), fatty acid synthesis (via FASN), phosphoinositide 3-kinases (PI3K), or by limiting amounts of sugar and amino acids ingested while also receiving KHK inhibitors, GLUT5 inhibitors, FASN inhibitors, PI3K inhibitors, or a combination of such inhibitors. |
| FILED | Friday, March 20, 2020 |
| APPL NO | 17/441416 |
| CURRENT CPC | Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 33/20 (20160801) Original (OR) Class Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220400987 | Khan et al. |
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| APPLICANT(S) | Yale University (New Haven, Connecticut) |
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| INVENTOR(S) | Muhammad Khan (New Haven, Connecticut); Sandeep Kumar Mishra (New Haven, Connecticut); ABM Zakaria (New Haven, Connecticut); Jelena Mihailovic (New Haven, Connecticut); Daniel Coman (New Haven, Connecticut); Fahmeed Hyder (New Haven, Connecticut) |
| ABSTRACT | Paramagnetic sodium NMR biosensors and associated methods are described herein. In one embodiment, a method for detecting sodium ion irregularities in a patient can include administering a volume of metallic biosensors to a region of the patient; and detecting a volume of compartmentalized sodium ions within the region based on the administered volume of metallic biosensors, which comprises a paramagnetic cation (such as, but not limited to, a lanthanide (III) metal ion and/or a transition (II) metal ion) as the core bound to an anionic macrocyclic chelate. In some cases, the volume of compartmentalized sodium ions can further include a volume of intracellular sodium ions, a volume of interstitial sodium ions, a volume of blood sodium ions, or a combination thereof. |
| FILED | Friday, June 10, 2022 |
| APPL NO | 17/806288 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/14546 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401023 | Madabhushi et al. |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio); The United States Govemment as Represented by The Department of Veteran Affairs (Washington, District of Columbia) |
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| INVENTOR(S) | Anant Madabhushi (Shaker Heights, Ohio); Mohammadhadi Khorrami (Cleveland Heights, Ohio); Prantesh Jain (Cleveland, Ohio); Afshin Dowlati (Solon, Ohio) |
| ABSTRACT | Various embodiments of the present disclosure are directed towards a method for predicting a response to treatment of small cell lung cancer (SCLC). The method includes generating a radiomic risk score (RRS) for the patient based on a plurality of radiomic features, wherein the RRS is prognostic of overall survival (OS) of the patient. The RRS is provided to a machine learning classifier that is trained to predict a response of the patient to a SCLC chemotherapy treatment based, at least in part, on the RRS. The machine learning classifier provides a classification of the patient into either a responder group (RG) or a non-responder group (NRG), where the NRG indicates the patient will not respond to the SCLC chemotherapy treatment and the RG indicates that the patient will respond to the SCLC chemotherapy treatment. |
| FILED | Friday, November 19, 2021 |
| APPL NO | 17/530711 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4848 (20130101) Original (OR) Class A61B 5/7267 (20130101) A61B 5/7275 (20130101) A61B 2576/02 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/10081 (20130101) G06T 2207/10116 (20130101) G06T 2207/30061 (20130101) G06T 2207/30096 (20130101) Image or Video Recognition or Understanding G06V 10/44 (20220101) G06V 10/764 (20220101) G06V 10/774 (20220101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/10 (20180101) G16H 30/40 (20180101) G16H 50/20 (20180101) G16H 50/30 (20180101) G16H 50/70 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401073 | KONOFAGOU et al. |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| INVENTOR(S) | Elisa E. KONOFAGOU (New York, New York); Alireza NABAVIZADEHRAFSANJANI (Ann Arbor, Michigan) |
| ABSTRACT | The present subject matter relates to techniques for harmonic motion elastography. The disclosed system can include a focused ultrasound (FUS) transducer for applying a push to a target tissue; an imaging transducer for obtaining radio frequency (RF) signals from the target tissue, and a processor configured to estimate the mechanical properties of the target tissue by extracting a shear wave from the RF signals and estimating a shear wave speed. |
| FILED | Friday, May 06, 2022 |
| APPL NO | 17/738410 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/08 (20130101) A61B 8/48 (20130101) Original (OR) Class A61B 8/5223 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401285 | Murphy et al. |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Patrick Murphy (Cambridge, Massachusetts); Brendan Thomas Quinlivan (Cambridge, Massachusetts); David Christopher Perry (Cambridge, Massachusetts); Asa M. Eckert-Erdheim (Cambridge, Massachusetts); Dorothy Cecile Orzel (Cambridge, Massachusetts); Taylor Beth Greenberg-Goldy (Cambridge, Massachusetts); Conor J. Walsh (Cambridge, Massachusetts) |
| ABSTRACT | In some embodiments, a device for assisting motion of a joint may include a first anchor on a first side of the joint, a second anchor on a second side of the joint, a spring operatively coupled to the first anchor and the second anchor, and an actuator operatively coupled to the first anchor and the second anchor. Actuating the actuator may apply a torque about the joint that is resisted by a reaction torque applied to the joint by the spring. |
| FILED | Tuesday, November 17, 2020 |
| APPL NO | 17/777972 |
| CURRENT CPC | Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 1/024 (20130101) A61H 1/0244 (20130101) A61H 1/0266 (20130101) A61H 3/00 (20130101) Original (OR) Class A61H 2201/149 (20130101) A61H 2201/165 (20130101) A61H 2201/1215 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401367 | Scott et al. |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
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| INVENTOR(S) | Evan Alexander Scott (Evanston, Illinois); Michael Patrick Vincent (Evanston, Illinois); Sharan Kumar Reddy Bobbala (Evanston, Illinois) |
| ABSTRACT | Provided herein are rehydratable powdered formulations of nanocarriers that can be used to encompass hydrophobic or hydrophilic cargo. The formulations can be used for medicinal, agricultural, and research applications. Methods of making the formulations are also provided. |
| FILED | Thursday, June 16, 2022 |
| APPL NO | 17/807372 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1623 (20130101) A61K 9/1641 (20130101) A61K 9/1647 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401374 | Yeo et al. |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Yoon Yeo (West Lafayette, Indiana); Maie S. Taha (Giza, EG, Egypt) |
| ABSTRACT | The present disclosure generally relates to a composition matter and a method for cancer treatment comprising albumin (alb) coated tannic acid-Fe nanoparticles (NPs) with a therapeutic compound, and one or more diluents, excipients or carriers. In particular, the present invention provides a treatment by enhancing antitumor immunity using tannic acid-based nanoparticles containing a therapeutic cancer treatment that can induce immunogenic cell death (ICD). The method disclosed herein provides a potential solution to the immunotoxicity accompanying the ICD cancer immunotherapy by intratumoral or intravenous administration of a nanocapsule formulation of carfilzomib (CFZ), an ICD-inducing proteasome inhibitor, using interfacial supramolecular assembly of tannic acid (TA) and iron, supplemented with albumin coating for better metabolic stability. |
| FILED | Friday, September 11, 2020 |
| APPL NO | 17/641124 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/4858 (20130101) A61K 9/5052 (20130101) Original (OR) Class A61K 38/07 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401391 | APKARIAN |
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| APPLICANT(S) | Apkarian Technologies LLC (Chicago, Illinois) |
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| INVENTOR(S) | A. Vania APKARIAN (Chicago, Illinois) |
| ABSTRACT | The present disclosure features combinations of dopaminergic agents and analgesic agents useful for treating pain. In particular, the combinations feature a low ratio of dopaminergic agent to analgesic agent. The dopaminergic agent can be an agonist of the dopamine receptor D1-like family or the dopamine receptor D2-like family. Such combinations potentiate analgesia to 1) alleviate acute pain, 2) prevent the transition from acute pain to chronic pain, and 3) manage chronic pain. |
| FILED | Friday, May 08, 2020 |
| APPL NO | 17/610025 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/167 (20130101) Original (OR) Class A61K 31/192 (20130101) A61K 31/198 (20130101) A61K 31/425 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401428 | Despa |
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| APPLICANT(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
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| INVENTOR(S) | Florin Despa (Lexington, Kentucky) |
| ABSTRACT | The presently-disclosed subject matter generally relates to methods for treating a subject with Alzheimer's Disease, microhemorrhages, and neurological deficits. The presently-disclosed subject matter also relates to methods for treating a subject with Alzheimer's Disease, microhemorrhages, and neurological deficits with a composition that increases epoxyeicosatrienoic acids. The presently-disclosed subject matter further relates to a method of treating or preventing Alzheimer's Disease comprising administering an agent that increases vascular LRP1 expression. |
| FILED | Thursday, October 01, 2020 |
| APPL NO | 17/764073 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4468 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1138 (20130101) C12N 2310/141 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401437 | Littleton et al. |
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| APPLICANT(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
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| INVENTOR(S) | John M. Littleton (Lexington, Kentucky); Bert Lynn (Lexington, Kentucky); Dennis T. Rogers (Lexington, Kentucky); Greg Gerhardt (Lexington, Kentucky) |
| ABSTRACT | The presently-disclosed subject matter describes Lobinaline N-oxides as modulators of the dopamine transporter. The presently-disclosed subject matter further describes to Lobinaline N-oxides as modulators of the nicotinic acetylcholine receptors. Also described herein are methods for treating substance abuse disorders comprising administering Lobinaline N-oxides to a subject in need thereof. |
| FILED | Wednesday, November 25, 2020 |
| APPL NO | 17/779678 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4725 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/32 (20180101) A61P 25/34 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401452 | Xu et al. |
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| APPLICANT(S) | The Board Of Regents of The University of Texas System (Austin, Texas) |
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| INVENTOR(S) | Kexin Xu (San Antonio, Texas); Chen-Hao Chen (Boston, Massachusetts); Xiaole Shirley Liu (Boston, Massachusetts); Myles Brown (Boston, Massachusetts) |
| ABSTRACT | Described here are methods of assessing response of a patient to an EZH2 inhibitor and methods of treating certain cancers by administering therapeutically effective amounts of an EZH2 inhibitor and a PARP-1 inhibitor. |
| FILED | Friday, June 26, 2020 |
| APPL NO | 17/596967 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/496 (20130101) A61K 31/502 (20130101) A61K 31/5377 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 13/08 (20180101) A61P 35/00 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401460 | Wu et al. |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
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| INVENTOR(S) | Catherine J. Wu (Boston, Massachusetts); Romain Guieze (Boston, Massachusetts) |
| ABSTRACT | This invention relates to compositions and methods for identifying the network that modulates, controls, or otherwise influences BCL-2 pathway inhibition, for example, energy-stress signaling, mitochondrial metabolism, vesicle transport, ribosomal components, and proteolysis. The invention also relates to identifying and modulating target genes and/or target gene products that modulate, control, or otherwise influence BCL-2 pathway inhibition. |
| FILED | Thursday, October 10, 2019 |
| APPL NO | 17/284111 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/145 (20130101) A61K 31/277 (20130101) A61K 31/352 (20130101) A61K 31/444 (20130101) A61K 31/519 (20130101) A61K 31/635 (20130101) Original (OR) Class A61K 31/4178 (20130101) A61K 31/7105 (20130101) A61K 38/50 (20130101) A61K 38/465 (20130101) A61K 39/3955 (20130101) A61K 48/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401478 | Rooney et al. |
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| APPLICANT(S) | Baylor College of Medicine (Houston, Texas) |
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| INVENTOR(S) | Cliona M. Rooney (Bellaire, Texas); Sandhya Sharma (Houston, Texas) |
| ABSTRACT | Methods for generating/expanding populations of immune cells comprising immune cells specific for an Epstein Barr Virus (EBV) lytic antigen are disclosed, the methods comprising stimulating immune cells specific for an EBV lytic antigen by contacting peripheral blood mononuclear cells (PBMCs) with: (i) one or more peptides corresponding to all or part of one or more EBV lytic antigens; or (ii) antigen presenting cells (APCs) presenting one or more peptides corresponding to all or part of one or more EBV lytic antigens. Also disclosed are populations of immune cells comprising immune cells specific for an EBV lytic antigen expanded according to such methods, and uses thereof. |
| FILED | Thursday, April 09, 2020 |
| APPL NO | 17/753875 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/05 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0638 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401490 | BARKER |
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| APPLICANT(S) | MEMORIAL SLOAN-KETTERING CANCER CENTER (New York, New York); MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES (New York, New York); SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (New York, New York) |
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| INVENTOR(S) | Juliet N. BARKER (New York, New York) |
| ABSTRACT | The present disclosure provides methods for treating hematologic malignancies in a recipient subject in need thereof comprising administering to the recipient subject an effective amount of donor myeloid progenitor cells, and an effective amount of donor umbilical cord blood (UCB) cells, wherein the UCB cells and the myeloid progenitor cells are HLA matched. In some embodiments, the donor for the myeloid progenitor cells is not related to the recipient subject and/or the donor for the UCB cells. Also disclosed herein are methods for promoting early myeloid recovery in a recipient subject following UCB transplantation. |
| FILED | Wednesday, June 15, 2022 |
| APPL NO | 17/841089 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) Original (OR) Class A61K 35/51 (20130101) A61K 2035/124 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/06 (20180101) A61P 35/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401535 | Kagan et al. |
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| APPLICANT(S) | Children's Medical Center Corporation (Boston, Massachusetts) |
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| INVENTOR(S) | Jonathan C. Kagan (Brookline, Massachusetts); Dania Zhivaki (Boston, Massachusetts) |
| ABSTRACT | The present application is related to cancer immunotherapy, e.g. stimulation of T cell mediated anti-tumor therapy. |
| FILED | Wednesday, November 18, 2020 |
| APPL NO | 17/777550 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) Original (OR) Class A61K 39/39 (20130101) A61K 45/06 (20130101) A61K 2039/5154 (20130101) A61K 2039/55572 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/064 (20130101) C12N 2500/36 (20130101) C12N 2501/22 (20130101) C12N 2501/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401536 | LEE |
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| FUNDED BY |
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| APPLICANT(S) | Sam LEE (Bellevue, Washington) |
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| INVENTOR(S) | Sam LEE (Bellevue, Washington) |
| ABSTRACT | Provided herein are compositions and methods for treating immune diseases or disorders, including cancer. In some embodiments, the compositions and methods are directed to the use of anti-DD1α antibodies to modulate the immune-regulatory activity of DD1α, thereby promoting anti-tumor immunity. Methods for identifying patients that are likely to respond to anti-DD1α therapy, and for treating such patients with anti-DD1α antibody compositions are also provided. |
| FILED | Thursday, June 16, 2022 |
| APPL NO | 17/842235 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401537 | SALTER et al. |
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| APPLICANT(S) | FRED HUTCHINSON CANCER RESEARCH CENTER (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander SALTER (Seattle, Washington); Stanley R. RIDDELL (Sammamish, Washington); Anusha RAJAN (Woodinville, Washington) |
| ABSTRACT | The present disclosure provides fusion proteins with improved signaling properties. Disclosed embodiments include fusion proteins that comprise an extracellular component comprising a target-binding domain, a transmembrane domain, and an intracellular component comprising a SH2 domain or a functional portion or variant thereof, and have improved signaling in response to antigen-binding, including of solid-tumor antigens with low levels of expression. Recombinant host cells expressing the fusion proteins, and polynucleotides encoding the fusion proteins, are also provided, as are compositions and methods comprising the same. |
| FILED | Tuesday, September 15, 2020 |
| APPL NO | 17/760747 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 39/00 (20130101) A61K 39/001102 (20180801) A61K 39/001112 (20180801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/71 (20130101) C07K 14/705 (20130101) C07K 14/7051 (20130101) C07K 14/70514 (20130101) C07K 14/70517 (20130101) C07K 14/70521 (20130101) C07K 14/70578 (20130101) C07K 14/70596 (20130101) C07K 16/2803 (20130101) C07K 2317/569 (20130101) C07K 2317/622 (20130101) C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 15/86 (20130101) C12N 15/625 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401542 | BAROUCH et al. |
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| FUNDED BY |
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| APPLICANT(S) | Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Dan H. BAROUCH (Newton, Massachusetts); Amanda J. MARTINOT (North Grafton, Massachusetts) |
| ABSTRACT | Disclosed herein are immunogenic compositions (e.g., vaccines) for use in the treatment of mycobacteria infections and biomarkers for monitoring of therapeutic responsiveness to the immunogenic compositions in a subject (e.g., a human). In a first aspect, the disclosure features a pharmaceutical composition containing between 1×10{circumflex over ( )}2 CPU and 1×10{circumflex over ( )}10 CPU of a Mycobacterium tuberculosis strain (Mtb) with one or more mutations that ablate or reduce expression of LprG and Rv1410 (ΔLprG Mtb) in a volume of between 0.05 mL and 3 mL. |
| FILED | Thursday, November 05, 2020 |
| APPL NO | 17/774385 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/04 (20130101) Original (OR) Class A61K 2039/522 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/06 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 1/36 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6869 (20130101) G01N 2333/54 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401546 | Amara et al. |
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| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rama Rao Amara (Atlanta, Georgia); Sailaja Gangadhara (Atlanta, Georgia); Anusmita Sahoo (Atlanta, Georgia); Tiffany Turner-Styles (Atlanta, Georgia) |
| ABSTRACT | This disclosure relates to HIV envelope proteins or envelope protein fragments, or trimeric complexes thereof which have uses in vaccination methods or therapeutic strategies. In certain embodiments, this disclosure relates to HIV envelope proteins or envelope protein fragments, or trimeric complexes thereof, comprising an arginine (R) at position 166, glutamine (Q) at position 170, and an amino acid histidine (H) at position 173. In certain embodiments, this disclosure relates to nucleic acids and recombinant vectors encoding said proteins. |
| FILED | Friday, November 13, 2020 |
| APPL NO | 17/776896 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class A61K 2039/55577 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Peptides C07K 14/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401547 | Zhu et al. |
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| FUNDED BY |
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| APPLICANT(S) | University Of Maryland (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaoping Zhu (Clarksville, Maryland); Weizhong Li (College Park, Maryland) |
| ABSTRACT | Disclosed are peptides comprising a monomeric Fc fragment of an immunoglobulin recognized by a neonatal receptor (FcRn); a modified pre-fusion respiratory syncytia virus (RSV) F protein; and a trimerization domain. Disclosed are nucleic acid sequences capable of encoding peptides comprising a monomeric Fc fragment of an immunoglobulin recognized by a neonatal receptor (FcRn); a modified pre-fusion respiratory syncytia virus (RSV) F protein; and a trimerization domain. Also disclosed are methods for eliciting a protective immune response against RSV comprising administering to a subject an effective amount of a composition comprising a monomeric Fc fragment of an immunoglobulin recognized by FcRn; a modified pre-fusion RSV F protein; and a trimerization domain, wherein the administering is to a mucosal epithelium. |
| FILED | Friday, June 03, 2022 |
| APPL NO | 17/831928 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class A61K 2039/55561 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/005 (20130101) C07K 16/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401554 | AGUILAR-CARRENO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hector AGUILAR-CARRENO (Ithaca, New York); Isaac MONREAL (Ithaca, New York); David BUCHHOLZ (Ithaca, New York) |
| ABSTRACT | The present application relates to method of vaccinating a subject against infection by an enveloped virus. The method includes providing a compound of the Formula (I) as described herein, and contacting the compound of Formula (I) with an isolated enveloped virus, having a membrane, to inactivate the membrane of the isolated enveloped virus. The subject is then treated with the enveloped virus having an inactivated membrane to vaccinate the subject against the enveloped virus. Further disclosed is an ex vivo vaccine composition including the compound of Formula (I) and an enveloped virus. |
| FILED | Friday, November 06, 2020 |
| APPL NO | 17/774632 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/13 (20130101) A61K 31/43 (20130101) A61K 31/65 (20130101) A61K 31/196 (20130101) A61K 31/265 (20130101) A61K 31/351 (20130101) A61K 31/407 (20130101) A61K 31/427 (20130101) A61K 31/496 (20130101) A61K 31/522 (20130101) A61K 31/546 (20130101) A61K 31/575 (20130101) A61K 31/662 (20130101) A61K 31/4164 (20130101) A61K 31/4709 (20130101) A61K 31/4965 (20130101) A61K 31/7048 (20130101) A61K 31/7056 (20130101) A61K 31/7072 (20130101) A61K 31/7076 (20130101) A61K 38/14 (20130101) A61K 38/212 (20130101) A61K 39/12 (20130101) A61K 39/21 (20130101) A61K 39/29 (20130101) Original (OR) Class A61K 39/145 (20130101) A61K 39/155 (20130101) A61K 39/205 (20130101) A61K 39/215 (20130101) A61K 39/245 (20130101) A61K 39/275 (20130101) A61K 2039/55505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) A61P 31/16 (20180101) A61P 31/22 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401562 | Brudno et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yevgeny Brudno (Somerville, Massachusetts); Cathal J. Kearney (Boston, Massachusetts); Eduardo Alexandre Barros E Silva (Davis, California); Michael Aizenberg (Cambridge, Massachusetts); Brian Kwee (Gaithersburg, Maryland); Rajiv Desai (San Diego, California); Neel Satish Joshi (Somerville, Massachusetts); David J. Mooney (Sudbury, Massachusetts) |
| ABSTRACT | The present invention provides refillable drug delivery systems, as well as methods of refilling the systems, and methods of using them to treat diseases. |
| FILED | Thursday, January 06, 2022 |
| APPL NO | 17/569720 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/0024 (20130101) A61K 31/704 (20130101) A61K 47/36 (20130101) A61K 47/549 (20170801) Original (OR) Class A61K 47/555 (20170801) A61K 47/6903 (20170801) A61K 49/0021 (20130101) A61K 49/0054 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2310/113 (20130101) C12N 2310/315 (20130101) C12N 2310/351 (20130101) C12N 2320/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401574 | Villanueva et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Flordeliza S. Villanueva (Pittsburgh, Pennsylvania); Xucai Chen (Glenshaw, Pennsylvania) |
| ABSTRACT | The presently disclosed drug-loaded liposomal conjugated to polymer microbubbles showed: i) increased tumor drug concentration; ii) reduced tumor growth; and ii) increased survival time in a mouse cancer model when exposed to concurrent high and low acoustic pressure ultrasonic pulses as compared to individual high or low acoustic pressure ultrasonic pulses. Notably, when unconjugated drug-loaded liposome were administered with free microbubbles and exposed to concurrent high and low acoustic pressure ultrasonic pulses, a superior tumor growth inhibition was also seen. Three weeks after treatments, DoxLPX+US group showed significantly better left ventricular function indices from echocardiography imaging than the free Dox group. Clinical methods using these liposomal conjugated microbubbles permit an increased therapeutic drug delivery and improved safety profile, respectively due to enhanced, preferential drug accumulation in target tumor tissue and simultaneously reduced drug delivery to non-target tissue. |
| FILED | Friday, November 13, 2020 |
| APPL NO | 17/773974 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1658 (20130101) A61K 41/0028 (20130101) A61K 47/665 (20170801) A61K 47/6925 (20170801) Original (OR) Class A61K 49/223 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401575 | Mao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hai-Quan Mao (Baltimore, Maryland); Yizong Hu (Baltimore, Maryland); Martin Gilbert Pomper (Baltimore, Maryland); Heng-wen Liu (Baltimore, Maryland); Il Minn (Baltimore, Maryland); Christopher Ullman (Baltimore, Maryland); Christine Carrington (Baltimore, Maryland) |
| ABSTRACT | The presently disclosed subject matter provides a kinetically controlled mixing process, referred to herein as “flash nanocomplexation” or “(FNC),” to accelerate the mixing of a polyanion solution, for example, a plasmid DNA solution, with a polycation solution to match the polyelectrolyte complex (PEC) assembly kinetics through turbulent mixing in a microchamber, thus achieving explicit control of the kinetic conditions for nanoparticle assembly as demonstrated by the tunability of nanoparticle size, composition, hydrodynamic size, hydrodynamic density, surface charge, and polyanion payload. |
| FILED | Wednesday, April 29, 2020 |
| APPL NO | 17/606605 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5146 (20130101) A61K 47/6929 (20170801) Original (OR) Class A61K 48/0091 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/88 (20130101) C12N 15/113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401580 | Ambati et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia); University of Utah Research Foundation (Salt Lake City, Utah) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, None); University of Utah Research Foundation (Salt Lake City, Utah) |
| INVENTOR(S) | Jayakrishna Ambati (Charlottesville, None); Bradley David Unti Gelfand (Charlottesville, Virginia); Balamurali K. Ambati (Eugene, None); Hironori Uehara (Salt Lake City, None) |
| ABSTRACT | Provided are nucleotide sequences encoding polypeptides with ribonuclease III activity, wherein the nucleotide sequences have been modified to reduce their regulation by miRNAs. In some embodiments, the nucleotide sequences are at least 50% and as much as 100% identical to SEQ ID NO: 20 or SEQ ID NO: 22, and/or encode polypeptides that are at least 90% percent identical to SEQ ID NO: 23. Also provided are vectors and host cells that include the nucleotide sequences, methods for expressing the nucleotide sequences in cells, tissues, and organs, which in some embodiments can be in the eye of a subject in need thereof, methods for preventing and/or treating development of diseases or disorders and/or for restoring undesirably low DICER1 expression using the nucleotide sequences, and pharmaceutical compositions that have the presently disclosed nucleotide sequences. |
| FILED | Thursday, November 12, 2020 |
| APPL NO | 17/776563 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) Peptides C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/16 (20130101) C12N 2750/14143 (20130101) Enzymes C12Y 301/26003 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) G01N 2800/164 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401592 | Pomper et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin G. Pomper (Baltimore, Maryland); Wojciech Lesniak (Owings Mills, Maryland); Emad Boctor (Ellicott City, Maryland); Sangeeta Banerjee Ray (Ellicott City, Maryland); Srikanth Boinapally (Baltimore, Maryland); Jeeun Kang (Baltimore, Maryland); Yixuan Wu (Baltimore, Maryland) |
| ABSTRACT | Poly(amidoamine) [PAMAM] dendrimers for use as PSMA-targeted contrast agents for optical and photoacoustic imaging (PA) and theranostic agents for treating prostate cancer are disclosed. |
| FILED | Friday, May 13, 2022 |
| APPL NO | 17/744080 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/60 (20170801) A61K 47/547 (20170801) A61K 49/0032 (20130101) A61K 51/0482 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401622 | Bharti et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| ASSIGNEE(S) | THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| INVENTOR(S) | Kapil Bharti (Potomac, Maryland); Min Jae Song (Olney, Maryland); Russell Louis Quinn (Washington, District of Columbia) |
| ABSTRACT | Methods are disclosed for fabricating a three-dimensional engineered blood retinal barrier (BRB) comprising a choroid and retinal pigment epithelial cells. The methods include the use of bioprinting. Also disclosed is a three-dimensional engineered BRB, and its use. Methods are also disclosed for using the three-dimensional engineered BRB, such as for the treatment of retinal degeneration in a subject or screening. A three-dimensional printing insert that is adapted for bioprinting on a culture substrate sheet that is securely retained within and exposed through a printing frame is also disclosed. |
| FILED | Wednesday, August 24, 2022 |
| APPL NO | 17/894773 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) A61L 27/24 (20130101) A61L 27/52 (20130101) A61L 27/56 (20130101) A61L 27/3808 (20130101) A61L 27/3813 (20130101) Original (OR) Class A61L 27/3891 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/069 (20130101) C12N 5/0621 (20130101) C12N 5/0656 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401672 | TRUMBOWER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SPAULDING REHABILITATION HOSPITAL CORPORATION (Charlestown, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Randy D. TRUMBOWER (Charlestown, Massachusetts); Jeremy J. PAPADOPOULOS (Charlestown, Massachusetts); Andrew Q. TAN (Charlestown, Massachusetts); Anthony N. CORSTEN (Charlestown, Massachusetts) |
| ABSTRACT | Systems and methods for hypoxia delivery are provided. An apparatus for providing intermittent normoxia and hypoxia intervals includes a breathing component, a normoxia fluid source, a hypoxia fluid source, a valve, and a control system. The valve is configured to disrupt flow from at least one of the normoxia fluid source and the hypoxia fluid source and the control system is configured to cause the at least one valve to switch between delivery of fluid from the normoxia fluid source and the hypoxia fluid source while maintaining positive pressure at the breathing component. |
| FILED | Monday, October 26, 2020 |
| APPL NO | 17/771328 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 16/06 (20130101) A61M 16/22 (20130101) A61M 16/024 (20170801) Original (OR) Class A61M 16/0045 (20130101) A61M 16/0066 (20130101) A61M 16/0078 (20130101) A61M 16/107 (20140204) A61M 16/125 (20140204) A61M 16/204 (20140204) A61M 16/0833 (20140204) A61M 16/1005 (20140204) A61M 2205/3368 (20130101) A61M 2230/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401679 | Ward et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Rochester (Rochester, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Denham Ward (Pittsford, New York); Suzanne Karan (Rochester, New York) |
| ABSTRACT | The present invention provides a method and apparatus for treating a subject suffering from obstructive sleep apnea (OSA). In one embodiment, the method of the present invention is configured to deliver negative airway pressure to a subject's airway to strengthen the airway muscle tone. |
| FILED | Friday, June 17, 2022 |
| APPL NO | 17/843039 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 16/0605 (20140204) Original (OR) Class A61M 2016/0018 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401746 | Graudejus et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BMSEED LLC (Phoenix, Arizona) |
| ASSIGNEE(S) | BMSEED LLC (Phoenix, Arizona) |
| INVENTOR(S) | Oliver Graudejus (Tempe, Arizona); Cami C. Rowan (Tempe, Arizona); Timothy M. Otchy (Brooklyn, New York) |
| ABSTRACT | A peripheral nerve interface including a microclip having a substantial U-shape and including an upper entry portion for entry of a nerve into the microclip and a lower seating portion for seating the nerve in the lower seating portion of the microclip; a stretchable microelectrode array including a plurality of electrodes, wherein the stretchable microelectrode array has a proximal end portion fixed to the microclip and a portion that is moveable and dragged into the upper entry portion and then the lower entry portion of the microclip in response to the microclip be positioned on the nerve; and an interface connected to a distal end of the stretchable microelectrode array and configured to interface with an external device for applying electrical stimulation to the nerve seated in the lower seating portion and for recording electrical characteristic of the nerve seated in the lower seating portion via the plurality of electrodes in the stretchable microelectrode array. |
| FILED | Tuesday, June 14, 2022 |
| APPL NO | 17/840275 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0556 (20130101) A61N 1/36053 (20130101) A61N 1/37205 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401751 | Lee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jin Hyung Lee (Palo Alto, California); Andrew J. Weitz (Bishop, California); Hyun Joo Lee (Palo Alto, California) |
| ABSTRACT | Provided herein are methods and systems for modulating temporal patterns of neuronal activity in the brain. A method of the present disclosure may include using optogenetics to stimulate a one or more of thalamocortical projections, thalamic relay neurons, cortical projection neurons, cell bodies in a thalamic submedial nucleus, and cell bodies in the VLO in the brain, in conjunction with fMRI of different regions of the brain to directly visualize the global influence of the VLO's afferent and efferent connections, and characterize how different temporal patterns of activity in the VLO circuit affect brain dynamics by driving its input and output at distinct frequencies. |
| FILED | Thursday, September 24, 2020 |
| APPL NO | 17/642632 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/067 (20210801) A61N 5/0622 (20130101) Original (OR) Class A61N 2005/0626 (20130101) A61N 2005/0652 (20130101) A61N 2005/0663 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/4806 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401753 | Greene et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark Greene (Penn Valley, Pennsylvania); Hongtao Zhang (Paoli, Pennsylvania); Hiromichi Tsuchiya (Philadelphia, Pennsylvania); Yasuhiro Nagai (Philadelphia, Pennsylvania); Lian Lam (Philadelphia, Pennsylvania); Aaron Runkle (Philadelphia, Pennsylvania); Jeffrey Drebin (Bryn Mawr, Pennsylvania); Mei Qing Ji (Voorhees, New Jersey) |
| ABSTRACT | Disclosed herein are methods of increasing response to radiation therapy in subjects afflicted with cancer. In some embodiments, the method comprises reducing the ability of an immune suppressor cell (e.g., MDSC) to migrate to the microenvironment of the cancer. In some embodiments, the method further comprises suppressing the migration of the immune suppressor cell to a non-malignant cell and/or suppressing the malignant transformation of the non-malignant cells. |
| FILED | Wednesday, August 10, 2022 |
| APPL NO | 17/818854 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/10 (20130101) Original (OR) Class A61N 2005/1098 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401955 | RAJARAMAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida); The Administrators of the Tulane Educational Fund (New Orleans, Louisiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Swaminathan RAJARAMAN (Winter Park, Florida); Michael J. MOORE (New Orleans, Louisiana); Charles M. DIDIER (Dunedin, Florida); Julia FREITAS ORRICO (Orlando, Florida) |
| ABSTRACT | A three-dimensional (3D) microelectrode array for in vitro electrical and microfluidic interrogation of electrogenic cell constructs includes a substrate having a plurality of micro vias. A hypodermic microneedle is received within each micro via of a first subgroup of the plurality of micro vias and each has a length that exceeds the thickness of the substrate to form a hypodermic microneedle array on the top face of the substrate. Metallic traces are formed on the bottom face and interconnect the hypodermic microneedles. A culturing area is formed in the top face. |
| FILED | Monday, June 06, 2022 |
| APPL NO | 17/805478 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) Original (OR) Class B01L 2300/0636 (20130101) B01L 2300/0672 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401960 | van Dam et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | R. Michael van Dam (Los Angeles, California); Jia Wang (Los Angeles, California); Alejandra Rios (Los Angeles, California); Philip Chao (Los Angeles, California); Jason Jones (Los Angeles, California) |
| ABSTRACT | A radiosynthesis system is disclosed that leverages droplet microfluidic radiosynthesis and its inherent advantages including reduction of reagent consumption and the ability to achieve high molar activity even when using low starting radioactivity. The radiosynthesis system enables the parallel synthesis of radiolabeled compounds using droplet-sized reaction volumes. In some embodiments, a single heater is used to create multiple reaction or synthesis sites. In other embodiments, separate heaters are used to create independently-controlled heating conditions at the multiple reaction or synthesis sites. In one embodiment, a four-heater setup was developed that utilizes a multi-reaction microfluidic chip and was assessed for the suitability with high-throughput radiosynthesis optimization. Replicates of several radiochemical operations including the full synthesis of various PET tracers revealed the platform to have high repeatability (e.g., consistent fluorination efficiency). The system may also be used for synthesis optimization. |
| FILED | Friday, August 07, 2020 |
| APPL NO | 17/622206 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5085 (20130101) B01L 7/00 (20130101) Original (OR) Class B01L 2300/165 (20130101) B01L 2300/0663 (20130101) B01L 2300/0829 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 35/0099 (20130101) G01N 2033/0093 (20130101) G01N 2035/00376 (20130101) G01N 2035/00445 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220402876 | Raines et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ronald T. Raines (Cambridge, Massachusetts); Brian Gold (Albuquerque, New Mexico); Jesus M. Dones (Princeton, New Jersey); Nile S. Abularrage (Boston, Massachusetts); Brian James Graham (Belmont, Massachusetts) |
| ABSTRACT | Provided herein are dibenzocyclooctyne compounds useful as reagents in 1,3-dipolar cycloaddition reactions, and methods for their preparation. |
| FILED | Friday, April 29, 2022 |
| APPL NO | 17/661440 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 13/547 (20130101) C07C 2603/36 (20170501) Heterocyclic Compounds C07D 221/16 (20130101) Original (OR) Class C07D 231/54 (20130101) C07D 249/16 (20130101) C07D 471/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220402880 | ZAWARE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Icahn School of Medicine At Mount Sinai (New York, New York) |
| ASSIGNEE(S) | Icahn School of Medicine At Mount Sinai (New York, New York) |
| INVENTOR(S) | Nilesh ZAWARE (Jamaica, New York); Ming-Ming ZHOU (Old Greenwich, Connecticut); Chunyan REN (Malden, Massachusetts); Claudia KIM (New York, New York); Sudeh IZADMEHR (New York, New York); Matthew GALSKY (New York, New York) |
| ABSTRACT | A genus of bicyclic inhibitors of CBX chromodomains is disclosed. The compounds are of the following genus: The compounds inhibit CBX proteins and, as a consequence, they are useful for treating prostate cancer, ovarian cancer, and B-cell lymphoma. |
| FILED | Wednesday, September 23, 2020 |
| APPL NO | 17/753980 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 209/08 (20130101) C07D 235/30 (20130101) Original (OR) Class C07D 403/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220402899 | SMITH, III et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania); DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amos B. SMITH, III (Merion, Pennsylvania); Althea Erica GAFFNEY (Alexandria, Virginia); Joseph G. SODROSKI (Medford, Massachusetts) |
| ABSTRACT | The present disclosure provides compounds of Formula (I) or pharmaceutically acceptable salts thereof: (I) wherein, R1 to R6 and X are defined herein. Also provided are pharmaceutical compositions comprising these compounds, methods for treating Human Immunodeficiency Virus (HIV-1) in a subject in need thereof using these compounds or pharmaceutical compositions, and methods for stabilizing the state-1 conformation of the HIV-1 envelope glycoproteins using these compounds or pharmaceutical compositions. |
| FILED | Thursday, October 01, 2020 |
| APPL NO | 17/765983 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Heterocyclic Compounds C07D 209/20 (20130101) C07D 403/12 (20130101) C07D 405/04 (20130101) C07D 405/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220402908 | PEDDIBHOTLA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sanford Burnham Prebys Medical Discovery Institute (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Satyamaheshwar PEDDIBHOTLA (Orlando, Florida); Paul M. HERSHBERGER (Satellite Beach, Florida); Richard Jason KIRBY (Newton, Massachusetts); Siobhan MALANY (Orlando, Florida); Layton H. SMITH (Orlando, Florida); Patrick R. MALONEY (Orlando, Florida); Hampton SESSIONS (Orlando, Florida); Daniela DIVLIANSKA (Orlando, Florida); Anthony B. PINKERTON (Rancho Santa Fe, California) |
| ABSTRACT | Provided herein are small molecule inhibitors of CXCR6 receptor, compositions comprising the compounds, and methods of using the compounds and compositions. The compounds are 9-azbicyclo[3.3.1]nonane or 9-diazbicyclo[3.3.1]nonane derivatives, whose synthesis is also described. Also provided are method of treating a disease or condition (such as, cancer) mediated by CXCR6/CXCL16 signaling pathway in a mammal. |
| FILED | Tuesday, July 07, 2020 |
| APPL NO | 17/625192 |
| CURRENT CPC | Heterocyclic Compounds C07D 451/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220402914 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiang Wang (Superior, Colorado); Xinfeng Wang (Boulder, Colorado) |
| ABSTRACT | The present inventions relates to tryptoline-based benzothiazole compounds and their use as both novel resistance modifying agents, and antibiotics. |
| FILED | Thursday, September 03, 2020 |
| APPL NO | 17/639016 |
| CURRENT CPC | Heterocyclic Compounds C07D 471/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220402975 | Belov et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George Belov (Rockville, Maryland); Siba K. Samal (Hyattsville, Maryland); Ekaterina Viktorova (Takoma Park, Maryland) |
| ABSTRACT | Provided are compositions and methods for vaccinating against picornaviruses. The compositions include modified Newcastle Disease viruses (NDVs) that are sufficient to produce virus-like particles (VLPs) in a host recipient. The modified NDVs contain a single stranded negative sense RNA polynucleotide having nucleotide sequences configured in a 3′-5′ direction encoding sequentially NDV nucleocapsid protein (NP), phosphoprotein (P), matrix protein (M), fusion protein (F), hemagglutinin-neuraminidase (HN) and RNA-dependent RNA polymerase (L) protein. A first nucleotide sequence encoding a picornavirus capsid polyprotein precursor is positioned between the between P and M nucleotide sequences. A second nucleotide sequence encoding a picornavirus protease that is capable of processing the capsid polyprotein precursor is positioned between the HN and L nucleotide sequences. Purified, infectious non-pathogenic NDV particles are included, as are methods for using such particles for vaccination against any infectious picornavirus. Kits and articles of manufacture containing and/or for making the NDV particles are also provided. |
| FILED | Thursday, February 03, 2022 |
| APPL NO | 17/592333 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/13 (20130101) A61K 2039/58 (20130101) Peptides C07K 14/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220402981 | Fischer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| INVENTOR(S) | Eric S. Fischer (Chestnut Hill, Massachusetts); Shourya Sonkar Roy Burman (Brookline, Massachusetts); Tyler Faust (Brookline, Massachusetts); Hojong Yoon (Cambridge, Massachusetts); Radoslaw P. Nowak (Boston, Massachusetts) |
| ABSTRACT | Described herein are compositions and methods for modulating protein abundance in a target-specific manner via degron tags. |
| FILED | Thursday, September 17, 2020 |
| APPL NO | 17/642874 |
| CURRENT CPC | Peptides C07K 14/4702 (20130101) Original (OR) Class C07K 2319/85 (20130101) C07K 2319/95 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/62 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220402996 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tong Zhang (Beijing, China PRC); Charles L. Sentman (West Lebanon, New Hampshire) |
| ABSTRACT | The present invention relates to chimeric immune receptor molecules for reducing or eliminating tumors. The chimeric receptors are composed a C-type lectin-like natural killer cell receptor, or a protein associated therewith, fused to an immune signaling receptor containing an immunoreceptor tyrosine-based activation motif. Methods for using the chimeric receptors are further provided. |
| FILED | Wednesday, June 15, 2022 |
| APPL NO | 17/841117 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 38/10 (20130101) A61K 45/06 (20130101) Peptides C07K 14/705 (20130101) Original (OR) Class C07K 14/715 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403005 | George et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE CHILDREN'S HOSPITAL OF PHILADELPHIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lindsey A. George (Haddonfield, New Jersey); Rodney M. Camire (Sicklerville, New Jersey) |
| ABSTRACT | Factor VIII variants and methods of use thereof are disclosed. In accordance with the present invention, compositions and methods for the modulation of hemostasis in patients in need thereof are provided. More specifically. Factor VIII (FVIII) variants which modulate (e.g., increase) hemostasis are provided. In a particular embodiment, the Factor VIII variant comprises at least one mutation at position 336 and/or 562. |
| FILED | Monday, December 07, 2020 |
| APPL NO | 17/777245 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/04 (20180101) Peptides C07K 14/755 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/79 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403014 | Simon et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel I. Simon (Moreland Hills, Ohio); Yunmei Wang (Cleveland, Ohio); Kevin Croce (Cleveland, Ohio); Matthew Bilodeau (Cleveland, Ohio) |
| ABSTRACT | A method of inhibiting hypercoagulation and/or thrombosis in a subject having or at risk of hypercoagulation or thrombosis includes administering to the subject an amount of a composition effective to inhibit MRP-8/14 and/or MRP-14 binding to platelet CD36 and inhibit hypercoagulation and/or thrombosis in the subject. |
| FILED | Wednesday, June 22, 2022 |
| APPL NO | 17/846697 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/177 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/18 (20130101) Original (OR) Class C07K 16/24 (20130101) C07K 16/2896 (20130101) C07K 2317/76 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403026 | BUTTE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Manish J. BUTTE (Los Angeles, California); Mohammad Mahdi HASANI-SADRABADI (Los Angeles, California); Fatemeh S. MAJEDI (Los Angeles, California) |
| ABSTRACT | An implantable or injectable scaffold comprising immunostimulatory compounds and a suppressor of regulatory T cell induction is provided for use in immunotherapy treatments, including the treatment of cancers and other tumors, in particular solid tumors including inoperable tumors, as well as for other applications of immune enhancement and/or suppression. |
| FILED | Friday, September 18, 2020 |
| APPL NO | 17/638519 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/246 (20130101) C07K 16/247 (20130101) C07K 16/248 (20130101) C07K 16/2809 (20130101) Original (OR) Class C07K 16/2818 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403036 | Lowenstein |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE JOHN'S HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles J. Lowenstein (Baltimore, Maryland) |
| ABSTRACT | Provided herein are methods of uses of a P-selectin inhibitor alone or in combination with a Von Willebrand factor (VWF) inhibitor. The methods include the administration of a P-selectin inhibitor alone or in combination with a Von Willebrand factor (VWF) inhibitor for the treatment of COVID-19 associated endothelial injury and/or reducing the risk of thrombosis in a subject of need thereof. |
| FILED | Thursday, June 16, 2022 |
| APPL NO | 17/842580 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) A61K 9/0029 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 13/12 (20180101) Peptides C07K 16/2854 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403051 | POWELL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel J. POWELL (Bala Cynwyd, Pennsylvania); Nicholas MINUTOLO (Philadelphia, Pennsylvania); Michael FARWELL (Wynnewood, Pennsylvania) |
| ABSTRACT | The present invention includes compositions and methods that utilize a Universal Immune Receptor (UnivIR) CAR system comprising a modified T cell comprising a DOTA CAR and a DOTA-conjugated targeting ligand. In certain embodiments, the invention includes methods for treating, ameliorating, and/or preventing cancer. In certain embodiments, the invention provides a set of complementary molecular imaging tools that is applicable to CAR T cell therapy. |
| FILED | Thursday, April 23, 2020 |
| APPL NO | 17/605945 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 47/6803 (20170801) A61K 51/0482 (20130101) A61K 51/1045 (20130101) Heterocyclic Compounds C07D 257/02 (20130101) Peptides C07K 14/7051 (20130101) C07K 16/44 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/622 (20130101) C07K 2319/03 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403091 | Nash et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Landon D. Nash (Sunnyvale, California); Kendal P. Ezell (Tomball, Texas) |
| ABSTRACT | An embodiment includes a system comprising: an iodine containing thermoset open-cell shape memory polymer (SMP) foam that is x-ray visible; wherein (a) the SMP foam is configured to expand from a compressed secondary state to an expanded primary state in response to thermal stimulus, (b) the SMP foam is a poly(urethane-urea-amide). Other embodiments are described herein. |
| FILED | Friday, August 05, 2022 |
| APPL NO | 17/881695 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/73 (20130101) C08G 18/3206 (20130101) C08G 18/3215 (20130101) C08G 18/3275 (20130101) Original (OR) Class C08G 18/3821 (20130101) C08G 18/3897 (20130101) C08G 18/5018 (20130101) C08G 2280/00 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/0066 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403172 | HELGASON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VitroLabs Inc (South San Francisco, California); King's College London (London, United Kingdom) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ingvar HELGASON (South San Francisco, California); Dusko ILIC (London, United Kingdom) |
| ABSTRACT | Disclosed herein are synthetic leathers, artificial epidermal layers, artificial dermal layers, layered structures, products produced therefrom and methods of producing the same. |
| FILED | Monday, May 23, 2022 |
| APPL NO | 17/751440 |
| CURRENT CPC | Compositions of Macromolecular Compounds C08L 89/06 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0625 (20130101) C12N 5/0629 (20130101) C12N 5/0698 (20130101) C12N 11/02 (20130101) C12N 2501/155 (20130101) C12N 2501/385 (20130101) C12N 2502/13 (20130101) C12N 2502/091 (20130101) C12N 2502/094 (20130101) C12N 2506/45 (20130101) C12N 2533/30 (20130101) C12N 2533/54 (20130101) Chemical Treatment of Hides, Skins or Leather, e.g Tanning, Impregnating, Finishing; Apparatus Therefor; Compositions for Tanning C14C 3/02 (20130101) C14C 13/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403344 | Jaenisch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Whitehead Institute for Biomedical Research (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rudolf Jaenisch (Brookline, Massachusetts); Konrad Hochedlinger (Cambridge, Massachusetts) |
| ABSTRACT | The invention provides methods for reprogramming somatic cells to generate multipotent or pluripotent cells. Such methods are useful for a variety of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that reprograms somatic cells to a less differentiated state. |
| FILED | Monday, August 29, 2022 |
| APPL NO | 17/898360 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0273 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0696 (20130101) Original (OR) Class C12N 15/85 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403349 | KORMAN |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | INVIZYNE TECHNOLOGIES, INC. (Monrovia, California) |
| ASSIGNEE(S) | INVIZYNE TECHNOLOGIES, INC. (Monrovia, California) |
| INVENTOR(S) | Tyler P. KORMAN (Sierra Madre, California) |
| ABSTRACT | The present disclosure relates to recombinant prenyltransferase enzymes with increased thermostability and activity and the use of these enzymes in compositions and methods for biosynthesis involving prenylation reactions, including compositions and methods for the preparation of cannabinoids. |
| FILED | Wednesday, May 25, 2022 |
| APPL NO | 17/824118 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1085 (20130101) Original (OR) Class C12N 15/52 (20130101) C12N 15/8243 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/42 (20130101) Enzymes C12Y 203/01206 (20150701) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403357 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| INVENTOR(S) | Feng Zhang (Cambridge, Massachusetts); Soumya Kannan (Cambridge, Massachusetts); Han Altae-Tran (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides small Cas proteins and their use in modifying target sequences. In one aspect, the present disclosure provides a non-naturally occurring or engineered system comprising: a Cas protein that comprises a RuvC domain and a HNH domain, and is less than 850 amino acids in size; and a guide sequence capable of forming a complex with the Cas protein and directing the complex to bind to a target sequence. |
| FILED | Thursday, November 12, 2020 |
| APPL NO | 17/776269 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 9/78 (20130101) C12N 15/11 (20130101) C12N 15/902 (20130101) C12N 15/8213 (20130101) C12N 2310/20 (20170501) Enzymes C12Y 305/04004 (20130101) C12Y 305/04005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403358 | PALESE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (New York, New York) |
| ASSIGNEE(S) | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (New York, New York) |
| INVENTOR(S) | Peter PALESE (New York, New York); Adolfo GARCIA-SASTRE (New York, New York); Florian KRAMMER (New York, New York) |
| ABSTRACT | In one aspect, provided herein are recombinant neuraminidases comprising an ectodomain of influenza virus neuraminidase with amino acid substitutions or insertions of cysteines in the stalk domain to generate a more stable, tetrameric influenza virus neuraminidase. In specific embodiments, the influenza virus neuraminidase further comprises influenza virus neuraminidase transmembrane and cytoplasmic domains. In another aspect, provided herein are recombinant neuraminidase comprising a globular head domain of influenza virus neuraminidase and a tetramerization domain, wherein the recombinant neuraminidase lacks influenza virus neuraminidase stalk, transmembrane and cytoplasmic domains. In another aspect, provided herein are methods of immunizing against influenza virus using such recombinant neuraminidases or compositions thereof. |
| FILED | Wednesday, October 21, 2020 |
| APPL NO | 17/770591 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) C07K 2319/02 (20130101) C07K 2319/03 (20130101) C07K 2319/21 (20130101) C07K 2319/43 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/2402 (20130101) Original (OR) Class C12N 2760/16122 (20130101) Enzymes C12Y 302/01018 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403367 | WANG |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (NEW YORK, New York) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (NEW YORK, New York) |
| INVENTOR(S) | Harris He WANG (New York, New York) |
| ABSTRACT | The present invention relates to utilizing engineered horizontal gene transfer elements and high-throughput selection strategies to tag and retrieve genetically modified native commensal strains from the mammalian gut. In certain aspects, the present invention relates to methods wherein isolated bacteria from the mammalian gut microbiome that were amenable to genetic manipulation were redeployed back into the mammalian subject as host-optimized engineerable probiotics. |
| FILED | Monday, January 13, 2020 |
| APPL NO | 17/422373 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/74 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 15/102 (20130101) Original (OR) Class C12N 15/1086 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403374 | SOUMILLON |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | FLEXOMICS, LLC (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Magali SOUMILLON (Boston, Massachusetts) |
| ABSTRACT | A system and method are provided for simplifying and accelerating the screening and characterization of molecular interactions by high-throughput functional screening and sequencing of single cells. More specifically, a platform is provided which combines a solid support and an innovative method for capturing and barcoding of nucleic acids that allows simultaneous phenotyping and genotyping of >100, 000s of cells. |
| FILED | Monday, September 30, 2019 |
| APPL NO | 17/639819 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 2021/6441 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403378 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yang Liu (Baltimore, Maryland); Roger Zou (Baltimore, Maryland); Bin Wu (Baltimore, Maryland); Taekjip Ha (Baltimore, Maryland) |
| ABSTRACT | A very fast and efficient CRISPR/Cas9 system is provided. Compositions include light-sensitive caged nucleotides at the PAM distal region of guide RNAs (gRNAcaged) to create artificial mismatches as a “roadblock”. Upon light stimulation, the caging group (“roadblock”) is removed and the gRNA fully hybridizes with the target DNA. Thus, the pre-bound inactive Cas9/gRNAcaged is rapidly converted to active Cas9. |
| FILED | Sunday, October 25, 2020 |
| APPL NO | 17/770512 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/111 (20130101) Original (OR) Class C12N 15/902 (20130101) C12N 2310/20 (20170501) C12N 2310/3511 (20130101) C12N 2320/11 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403380 | Lee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeannie T. Lee (Boston, Massachusetts); Michael Rosenberg (Brookline, Massachusetts); Barry Kesner (Charlestown, Massachusetts) |
| ABSTRACT | This invention relates to polycomb-associated RNAs, libraries and fragments of those RNAs, inhibitory nucleic acids and methods and compositions for targeting RNAs, and methods of use thereof. |
| FILED | Wednesday, September 30, 2020 |
| APPL NO | 17/038425 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/113 (20130101) C12N 2310/3231 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6883 (20130101) C12Q 1/6886 (20130101) C12Q 2600/158 (20130101) C12Q 2600/178 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403390 | Kogut et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Igor Kogut (Aurora, Colorado); Dennis R. Roop (Greenwood Village, Colorado); Ganna Bilousova (Aurora, Colorado) |
| ABSTRACT | The present disclosure relates to methods and compositions for reprogramming cells to a pluripotent state. In particular, it relates to an integration- and feeder cell-free method for reprogramming primary human fibroblast cells to induced pluripotent stem cells (iPSCs). |
| FILED | Wednesday, July 20, 2022 |
| APPL NO | 17/869514 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) A61K 35/28 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0652 (20130101) C12N 5/0696 (20130101) C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 15/907 (20130101) C12N 2310/20 (20170501) C12N 2310/141 (20130101) C12N 2330/31 (20130101) C12N 2500/60 (20130101) C12N 2501/65 (20130101) C12N 2501/115 (20130101) C12N 2501/602 (20130101) C12N 2501/603 (20130101) C12N 2501/604 (20130101) C12N 2501/605 (20130101) C12N 2501/606 (20130101) C12N 2501/608 (20130101) C12N 2506/1307 (20130101) C12N 2510/00 (20130101) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403392 | Afonin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Charlotte (Charlotte, North Carolina); The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kirill Afonin (Charlotte, North Carolina); Nikolay Dokholyan (Hummelstown, Pennsylvania) |
| ABSTRACT | This invention relates to nanofibers comprising aptamers, which have increased stability and activity relative to free aptamers. The invention further relates to kill-switch nanofibers which disrupt the aptamer nanofibers. The invention further relates to methods of using the aptamer nanofibers and the kill-switch nanofibers to regulate the activity of extracellular targets recognized by the aptamers. |
| FILED | Friday, July 29, 2022 |
| APPL NO | 17/816273 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/115 (20130101) Original (OR) Class C12N 2310/16 (20130101) C12N 2320/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403417 | Xie et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | University of Massachusetts (Boston, Massachusetts) |
| INVENTOR(S) | Jun Xie (Shrewsbury, Massachusetts); Guangping Gao (Westborough, Massachusetts) |
| ABSTRACT | In some aspects the disclosure provides compositions and methods for promoting expression of functional Thymine Kinase 2 (TK2) protein in a subject. In some embodiments, the disclosure provides methods of treating a subject having TK2 deficiency, for example a subject having mitochondrial DNA depletion syndrome. |
| FILED | Thursday, November 19, 2020 |
| APPL NO | 17/778212 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1211 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403424 | Rullán Lind et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Puerto Rico (San Juan, Puerto Rico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carlos Ralph Rullán Lind (San Juan, Puerto Rico); Abel Juan Baerga Ortiz (San Juan, Puerto Rico) |
| ABSTRACT | The disclosure provides fused dimer constructs that enhance fatty acid production and methods for making the dimer constructs. The fused dimer comprises Fab A and/or FabZ enzymes. |
| FILED | Thursday, March 05, 2020 |
| APPL NO | 17/435709 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/88 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/6409 (20130101) Original (OR) Class Enzymes C12Y 402/01059 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403442 | Matoori et al. |
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| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Simon Sam Matoori (Cambridge, Massachusetts); David J. Mooney (Sudbury, Massachusetts) |
| ABSTRACT | Described herein are compositions that are suitable for use in analyte sensing in biological samples and in medical diagnostics. The compositions include an oxidase capable of oxidizing the analyte of interest to produce hydrogen peroxide, a peroxidase, and a chemical compound, such as a near-infrared fluorescent compound, that is a substrate for the peroxidase. The oxidase, the peroxidase, and the chemical compound are encapsulated by vesicle that includes a lipid or polymeric bilayer, such as liposome and polymersome. The peroxidase catalyzes the oxidation of the chemical compound by hydrogen peroxide. Methods of analyte sensing in biological samples using these compositions, and methods of preparing the compositions are also described. |
| FILED | Tuesday, October 20, 2020 |
| APPL NO | 17/770146 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/28 (20130101) Original (OR) Class C12Q 1/61 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403443 | Lin et al. |
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| FUNDED BY |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hening Lin (Ithaca, New York); Maurine E. Linder (Ithaca, New York); Jun Young Hong (Ithaca, New York) |
| ABSTRACT | A method for determining activity of an acyl transferase enzyme, the method comprising: (i) preparing a reaction mixture comprising: (a) an acyl transferase enzyme, (b) a peptide substrate bound to a fluorophore, wherein the substrate is a cysteine-containing oligopeptide of 5-25 amino acids in length, (c) an acyl-CoA, and (d) a detergent comprising micelles, wherein the acyl transferase enzyme mediates acylation on a cysteine of said peptide substrate to result in association of the peptide with micelles of the detergent with resultant increase in fluorescence polarization; and (ii) measuring fluorescent signal of the reaction mixture; wherein an increase in fluorescence polarization of the reaction mixture compared to fluorescence polarization of a control reaction indicates acyl transferase activity of the acyl transferase enzyme. The above assay method may also be used for screening compounds for their ability to act as inhibitors of an acyl transferase enzyme. |
| FILED | Tuesday, June 14, 2022 |
| APPL NO | 17/840140 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/48 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2333/91051 (20130101) G01N 2500/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403449 | Song et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| INVENTOR(S) | Chunxiao Song (Oxford, United Kingdom); Stephen R. Quake (Stanford, California); Axel Brunger (Stanford, California); Jiajie Diao (Stanford, California) |
| ABSTRACT | Provided herein is a method for analyzing genomic DNA In some embodiments, the method may comprise labeling a genomic sample by adding a capture tag to the ends of the DNA molecules in the sample and labeling molecules that comprise hydroxymethylcytosine with a first fluorophore, immobilizing the labeled DNA molecules on a support, and imaging individual molecules of hydroxymethylated genomic DNA on the support. |
| FILED | Monday, November 29, 2021 |
| APPL NO | 17/537290 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6818 (20130101) Original (OR) Class C12Q 1/6834 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403465 | SIMS et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter A. SIMS (Ardsley, New York); Timothy R. OLSEN (New York, New York) |
| ABSTRACT | Single-cell multi-omics by co-encapsulating a single cell with two beads, the first an RNA barcoding bead having barcoded mRNA capture primer oligonucleotides attached on the bead surface; and the second a DNA barcoding bead having two types of oligonucleotides releasably attached to the surface: (1) barcoded adapter oligonucleotides that are complementary to oligonucleotides bound to the transposase that are eventually incorporated into gDNA fragments and (2) polyadenylated barcoded oligonucleotides containing the same barcode sequence as the adapters. In addition, integrated analysis of RNA and protein, including intracellular protein, from individual cells using similar co-encapsulation of a single cell, an RNA barcoding bead, and with/without a specific or non-specific protein binding bead in a microwell, to avoid protein fixation by first lysing the cell to liberate intracellular contents, and then capturing protein either on a solid surface or in solution with barcoded affinity reagents. |
| FILED | Friday, November 13, 2020 |
| APPL NO | 17/776655 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) C12N 15/1096 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6874 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403469 | Niculescu, III |
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| FUNDED BY |
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| APPLICANT(S) | Indiana University Research and Technology Corporation (Indianapolis, Indiana) |
| ASSIGNEE(S) | United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | Alexander Bogdan Niculescu, III (Indianapolis, Indiana) |
| ABSTRACT | Disclosed are novel compounds for treating and preventing schizophrenia, and more generally psychosis, by bioinformatics drug repurposing using novel genes expression biomarkers involved in psychotic symptoms (delusions, hallucinations); methods for assessing severity, determining future risk, matching with a drug treatment, and measuring response to treatment, for psychosis in a subject; and method of using repurposed drugs and natural compounds to prevent and to treat psychosis. Methods are disclosed using a universal approach, in everybody, as well as personalized approaches by gender. The discovery describes compounds for use in everybody (universal), as well as personalized by gender (males, females). Methods for identifying which subjects should be receiving which treatment, using genes expression biomarkers for patient stratification and measuring response to treatment. The disclosure also relates to algorithms. The algorithms combine biomarkers as well as clinical measures for psychosis, to identify subjects who are at risk of psychosis, and to track responses to treatments. |
| FILED | Thursday, June 17, 2021 |
| APPL NO | 17/351132 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/158 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 25/10 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403470 | GU et al. |
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| FUNDED BY |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| INVENTOR(S) | Zhenglong GU (Ithaca, New York); Xiaoxian GUO (Ithaca, New York); Yiqin WANG (Ithaca, New York); Ruoyu ZHANG (White Plains, None) |
| ABSTRACT | The present disclosure is directed to probe sets for sequencing a mitochondrial genomic DNA, methods of sequencing a mitochondrial DNA using the probe sets, and methods of designing probe sets for sequencing a mitochondrial genomic DNA. |
| FILED | Wednesday, September 16, 2020 |
| APPL NO | 17/760652 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/16 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403474 | SYMMANS et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas); Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas); Yale University (New Haven, Connecticut) |
| INVENTOR(S) | William Fraser SYMMANS (Houston, Texas); Bruno SINN (Berlin, Germany); Christos HATZIS (Guilford, Connecticut); Chunxiao FU (Pearland, Texas); Rosanna LAU (Houston, Texas) |
| ABSTRACT | Provided herein are methods of determining tumoral sensitivity to hormonal (endocrine) therapy based upon an index of estrogen receptor (ER)- and progesterone receptor (PR)-related genes, referred to as the sensitivity to endocrine therapy index (SETER/PR index), and may have additional consideration for the proportion of ER gene (ESR1) RNA transcripts that contain a mutation relative to the value of the SETER/PR index. Further provided are methods of treating breast cancer patients determined to be sensitive to an endocrine therapy by the SETER/PR index. |
| FILED | Thursday, August 25, 2022 |
| APPL NO | 17/822332 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/138 (20130101) A61K 31/566 (20130101) A61K 31/4196 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/112 (20130101) C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 25/10 (20190201) G16B 25/20 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220404334 | GURKAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | UMUT GURKAN (Cleveland, Ohio); ERDEM KUCUKAL (Cleveland, Ohio); UTKU GOREKE (Cleveland, Ohio); YUNCHENG MAN (Cleveland, Ohio) |
| ABSTRACT | A microfluidic system for measuring cell adhesion includes a gas impermeable housing including at least one microchannel defining at least one cell adhesion region, the at least one cell adhesion region being provided with at least one capturing agent that adheres a cell of interest to a surface of the at least one microchannel when a fluid sample containing cells is passed through the at least one microchannel, and an imaging system for measuring the adherence of cells of interest adhered by the at least one capturing agent to the surface of the at least one microchannel when the fluid sample is passed therethrough. |
| FILED | Friday, October 30, 2020 |
| APPL NO | 17/773774 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) B01L 2200/0647 (20130101) B01L 2300/16 (20130101) B01L 2300/0877 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/4915 (20130101) Original (OR) Class G01N 33/5044 (20130101) G01N 2800/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220404339 | Ekser |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF INDIANA UNIVERSITY (Indianapolis, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Burcin Ekser (Indianapolis, Indiana) |
| ABSTRACT | Disclosed is a spheroid liver organoid comprising hepatic lineage cells such as human hepatocytes, hepatic stellate cells, and liver sinusoidal endothelial cells. Also provided are methods of using spheroid liver organoids for applications related to drug screening and toxicity screening. In particular, spheroid liver organoids are useful for high-throughput screens to identify compounds having efficacy for treating liver disease. |
| FILED | Thursday, September 17, 2020 |
| APPL NO | 17/761121 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0671 (20130101) C12N 2501/15 (20130101) C12N 2501/42 (20130101) C12N 2501/415 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5023 (20130101) G01N 33/5082 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220404340 | Mead et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin Mead (Cambridge, Massachusetts); Conner Samuel Kummerlowe (Cambridge, Massachusetts); Alexander K. Shalek (Cambridge, Massachusetts) |
| ABSTRACT | Described in certain example embodiments herein are systems, methods, and uses thereof for high-throughput in vitro evaluating multiple test compounds in parallel for biological or pharmacological functions. In certain embodiments, the system allows the selection of a subset of test compounds from a group of test compounds to form an optimized pool, and methods are provided to use such optimized pool of test compounds to identify and validate therapeutic agents for treating diseases and driving guided differentiation of stem cells into desired types of cells. The systems described herein can provide, for example, a cost-effective and high-quality high-throughput approach for drug screening. |
| FILED | Friday, October 23, 2020 |
| APPL NO | 17/771309 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/502 (20130101) G01N 33/5082 (20130101) Original (OR) Class Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) G16B 40/20 (20190201) Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 20/50 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220404355 | CHATTERJEE et al. |
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| FUNDED BY |
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| APPLICANT(S) | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (Fort Collins, Colorado) |
| ASSIGNEE(S) | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (Fort Collins, Colorado) |
| INVENTOR(S) | Delphi CHATTERJEE (Fort Collins, Colorado); Charles S. HENRY (Fort Collins, Colorado) |
| ABSTRACT | The present invention relates generally to an assay for detecting and differentiating single or multiple analytes, if present, in a fluid sample, including devices and methods of use of the same. |
| FILED | Thursday, June 16, 2022 |
| APPL NO | 17/842210 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) B01L 2300/069 (20130101) B01L 2300/0867 (20130101) B01L 2300/0887 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/525 (20130101) G01N 33/558 (20130101) Original (OR) Class G01N 33/54366 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220404367 | LaBaer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Joshua LaBaer (Chandler, Arizona); Ji Qiu (Chandler, Arizona); Lusheng Song (Tempe, Arizona); Yunro Chung (Chandler, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joshua LaBaer (Chandler, Arizona); Ji Qiu (Chandler, Arizona); Lusheng Song (Tempe, Arizona); Yunro Chung (Chandler, Arizona) |
| ABSTRACT | Provided herein are methods, compositions, kits, and systems for diagnosing, predicting, and treating gastric cancer for a subject based on the presence and level of antibodies against particular H. pylori proteins in a biological sample obtained from the subject. In particular, provided herein are methods for identifying a subject having increased risk of developing gastric cancer, methods for detecting gastric cancer in a subject, methods for determining an H. pylori antibody signature comprising antibodies, contained in a biological sample from a subject, that specifically bind to immobilized H. pylori antigens, and kits comprising components and instructions for performing the methods of this disclosure. |
| FILED | Thursday, September 24, 2020 |
| APPL NO | 17/761653 |
| CURRENT CPC | Peptides C07K 16/121 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/543 (20130101) G01N 33/56922 (20130101) G01N 33/57446 (20130101) Original (OR) Class G01N 2333/205 (20130101) G01N 2469/20 (20130101) G01N 2800/7028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220405918 | Madabhushi et al. |
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| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio); The United States Government as Represented by The Department of Veteran Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anant Madabhushi (Shaker Heights, Ohio); Sepideh Azarianpour Esfahani (Cleveland Heights, Ohio); Haider Mahdi (Wexford, Pennsylvania) |
| ABSTRACT | Various embodiments of the present disclosure are directed towards a method for generating a risk group classification for an African American (AA) patient. The method includes extracting a first plurality of architectural features from a digitized H&E slide image of the AA patient. A risk score for the AA patient is generated based on the first plurality of architectural features, where the risk score is prognostic of overall survival (OS) of the AA patient. The risk group classification is generated for the AA patient, where generating the risk group classification includes classifying the AA patient into either a high risk group or a low risk group based on the risk score, where the high risk group indicates the AA patient will die before a threshold date and the low risk group indicates the AA patient will die after or on the threshold date. |
| FILED | Tuesday, February 15, 2022 |
| APPL NO | 17/671882 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 2207/30024 (20130101) G06T 2207/30096 (20130101) Image or Video Recognition or Understanding G06V 10/764 (20220101) G06V 10/774 (20220101) G06V 20/698 (20220101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220405923 | Pandolfino et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Erik Pandolfino (Wilmette, Illinois); Neelesh Ashok Patankar (Buffalo Grove, Illinois); Sourv Halder (Evanston, Illinois); Shashank Acharya (Evanston, Illinois); Peter James Kahrilas (Chicago, Illinois) |
| ABSTRACT | Flow through tubular organs (e.g., the esophagus) is analyzed based on fluid mechanics analysis of medical images. Using computational fluid dynamics, a reduced-order model is constructed and implemented to predict flow rate and fluid pressure developed inside flexible tubular organs inside the body. As one non-limiting example, the constructed model can be applied to analyze esophageal transport using fluoroscopy image sequences to predict flow rate, pressure, esophagus wall stiffness, and active relaxation. |
| FILED | Monday, November 23, 2020 |
| APPL NO | 17/779124 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 3/40 (20130101) G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 7/20 (20130101) G06T 2207/10064 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30092 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 15/00 (20180101) G16H 30/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220405931 | Madabhushi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anant Madabhushi (Shaker Heights, Ohio); Cheng Lu (Cleveland Heights, Ohio) |
| ABSTRACT | Embodiments include accessing an image of a region of tissue demonstrating cancerous pathology; detecting a plurality of cells represented in the image; segmenting a cellular nucleus of a first member of the plurality of cells and a cellular nucleus of at least one second, different member of the plurality of cells; extracting a set of nuclear morphology features from the plurality of cells; constructing a feature driven local cell graph (FeDeG) based on the set of nuclear morphology features and a spatial relationship between the cellular nuclei using a mean-shift clustering approach; computing a set of FeDeG features based on the FeDeG; providing the FeDeG features to a machine learning classifier; receiving, from the machine learning classifier, a classification of the region of tissue as a long-term or a short-term survivor, based, at least in part, on the set of FeDeG features; and displaying the classification. |
| FILED | Friday, August 26, 2022 |
| APPL NO | 17/896454 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 2207/10056 (20130101) G06T 2207/20081 (20130101) G06T 2207/30024 (20130101) G06T 2207/30061 (20130101) G06T 2207/30096 (20130101) Image or Video Recognition or Understanding G06V 20/698 (20220101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 40/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220405933 | Tajbakhsh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nima Tajbakhsh (Los Angeles, California); Jianming Liang (Scottsdale, Arizona) |
| ABSTRACT | Described herein are means for implementing annotation-efficient deep learning models utilizing sparsely-annotated or annotation-free training, in which trained models are then utilized for the processing of medical imaging. An exemplary system includes at least a processor and a memory to execute instructions for learning anatomical embeddings by forcing embeddings learned from multiple modalities; initiating a training sequence of an AI model by learning dense anatomical embeddings from unlabeled date, then deriving application-specific models to diagnose diseases with a small number of examples; executing collaborative learning to generate pretrained multimodal models; training the AI model using zero-shot or few-shot learning; embedding physiological and anatomical knowledge; embedding known physical principles refining the AI model; and outputting a trained AI model for use in diagnosing diseases and abnormal conditions in medical imaging. Other related embodiments are disclosed. |
| FILED | Friday, June 17, 2022 |
| APPL NO | 17/843817 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/0014 (20130101) Original (OR) Class Image or Video Recognition or Understanding G06V 10/82 (20220101) G06V 10/7747 (20220101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220406435 | Annunziata et al. |
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| FUNDED BY |
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| APPLICANT(S) | St. Jude Children's Research Hospital (Memphis, Tennessee) |
| ASSIGNEE(S) | St. Jude Children's Research Hospital (Memphis, Tennessee) |
| INVENTOR(S) | Ida Annunziata (Memphis, Tennessee); Alessandra D'Azzo (Memphis, Tennessee); Shai White-Gilbertson (North Charleston, South Carolina) |
| ABSTRACT | Methods are provided for the prognosis, diagnosis and treatment of various pathological states, including cancer, chemotherapy resistance and dementia associated with Alzheimer's disease. The methods provided herein are based on the discovery that various proteins with a high level of sialylation are shown herein to be associated with disease states, such as, cancer, chemotherapy resistance and dementia associated with Alzheimer's disease. Such methods provide a lysosomal exocytosis activity profile comprising one or more values representing lysosomal exocytosis activity. Also provided herein, is the discovery that low lysosomal sialidase activity is associated with various pathological states. Thus, the methods also provide a lysosomal sialidase activity profile, comprising one or more values representing lysosomal sialidase activity. A lysosomal sialidase activity profile is one example of a lysosomal exocytosis activity profile. |
| FILED | Thursday, August 18, 2022 |
| APPL NO | 17/820755 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/47 (20130101) A61K 38/48 (20130101) A61K 38/4813 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) General Methods of Organic Chemistry; Apparatus Therefor C07B 59/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/485 (20130101) C12N 9/2402 (20130101) C12N 15/11 (20130101) C12N 15/63 (20130101) C12N 15/86 (20130101) C12N 2320/30 (20130101) C12N 2710/10031 (20130101) C12N 2740/10041 (20130101) C12N 2750/14141 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/34 (20130101) Enzymes C12Y 302/01018 (20130101) C12Y 304/16005 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/573 (20130101) G01N 33/57484 (20130101) G01N 33/57496 (20130101) G01N 2333/924 (20130101) G01N 2800/56 (20130101) G01N 2800/2821 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/00 (20180101) G16H 20/40 (20180101) Original (OR) Class Technologies for Adaptation to Climate Change Y02A 90/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220406450 | Richter et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois); ANN AND ROBERT H. LURIE CHILDREN'S HOSPITAL OF CHICAGO (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Claus-Peter Richter (Skokie, Illinois); Minh Ha Tran (Laramie, Wyoming); Bharat Bhushan (Chicago, Illinois) |
| ABSTRACT | The invention relates to a novel method for scoring sleep stages of a mammal subject, comprising extracting features from polysomnography data using the continuous wavelet transform; grouping the extracted features into clusters that are assigned to different sleep stages; and scoring the sleep stages based on the clusters. The method does not require prior visual knowledge of sleep stages nor supervised training. |
| FILED | Monday, November 23, 2020 |
| APPL NO | 17/774535 |
| CURRENT CPC | Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 40/63 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220406461 | Kroncke |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brett M. Kroncke (Nashville, Tennessee) |
| ABSTRACT | Systems and methods for assessing a probability of a disease occurring in a patient based on an estimation of disease penetrance corresponding to a specific genetic variant of interest. An penetrance estimate is determined based on observed penetrance in patient data for the specific variant of interest and observed penetrance for a plurality of other variants that share some commonality with the specific variant of interest. The penetrance estimate is then refined by applying a recursive regression modeling until the penetrance estimate converges towards a final value. The probability of the disease occurring in a patient that has the specific variant of interest is then determined based on the posterior penetrance estimate as determined by the recursive regression modeling. |
| FILED | Tuesday, June 21, 2022 |
| APPL NO | 17/845492 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 7/08 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) G16H 50/20 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220406587 | MANICKE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas Edward MANICKE (Zionsville, Indiana); Brandon John BILLS (San Jose, California) |
| ABSTRACT | Disclosed herein are mass spectrometry sample substrates. Also disclosed herein are mass spectrometry sample strips and cartridges that include a solid phase extraction (SPE) element. The mass spectrometry sample substrates, sample strips, and cartridges can be used in paper spray mass spectrometry to detect and quantify one or more analytes present in a biological sample. Also disclosed are methods for collecting and concentrating one or more analytes from a biological sample, as well as for storing a biological sample that includes one or more analytes. Methods for analyzing the one or more analytes from the biological sample are also provided. |
| FILED | Friday, November 20, 2020 |
| APPL NO | 17/777191 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/94 (20130101) G01N 2560/00 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/0409 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20220401023 | Madabhushi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio); The United States Govemment as Represented by The Department of Veteran Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anant Madabhushi (Shaker Heights, Ohio); Mohammadhadi Khorrami (Cleveland Heights, Ohio); Prantesh Jain (Cleveland, Ohio); Afshin Dowlati (Solon, Ohio) |
| ABSTRACT | Various embodiments of the present disclosure are directed towards a method for predicting a response to treatment of small cell lung cancer (SCLC). The method includes generating a radiomic risk score (RRS) for the patient based on a plurality of radiomic features, wherein the RRS is prognostic of overall survival (OS) of the patient. The RRS is provided to a machine learning classifier that is trained to predict a response of the patient to a SCLC chemotherapy treatment based, at least in part, on the RRS. The machine learning classifier provides a classification of the patient into either a responder group (RG) or a non-responder group (NRG), where the NRG indicates the patient will not respond to the SCLC chemotherapy treatment and the RG indicates that the patient will respond to the SCLC chemotherapy treatment. |
| FILED | Friday, November 19, 2021 |
| APPL NO | 17/530711 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4848 (20130101) Original (OR) Class A61B 5/7267 (20130101) A61B 5/7275 (20130101) A61B 2576/02 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/10081 (20130101) G06T 2207/10116 (20130101) G06T 2207/30061 (20130101) G06T 2207/30096 (20130101) Image or Video Recognition or Understanding G06V 10/44 (20220101) G06V 10/764 (20220101) G06V 10/774 (20220101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/10 (20180101) G16H 30/40 (20180101) G16H 50/20 (20180101) G16H 50/30 (20180101) G16H 50/70 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401218 | Alghazali et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Little Rock, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karrer M. Alghazali (Little Rock, Arkansas); Viney Saini (Little Rock, Arkansas); Zeid A. Nima (Little Rock, Arkansas); Alexandru S. Biris (Little Rock, Arkansas); Shawn E. Bourdo (Little Rock, Arkansas) |
| ABSTRACT | A biocompatible structure includes a scaffold obtained from a 3D structure. The 3D structure includes base layered structures, each of which includes at least a first layer and a second layer surrounded by the first layer. The first layer includes at least one of first, second and third media. The second layer includes at least another of the first, second and third media. The first medium comprises bone particles. The second medium comprises a polymer dissolvable in a first solvent. The third medium comprises solid particulates dissolvable in a second solvent different than the first solvent. The 3D structure is treated with the second solvent to dissolve the solid particulates so as to form pores at positions of the solid particulates therein, thereby resulting in the scaffold having a porosity adjustable by sizes of the solid particulates and concentration of the solid particulates in the 3D structure. |
| FILED | Tuesday, August 23, 2022 |
| APPL NO | 17/893273 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/28 (20130101) Original (OR) Class A61F 2002/30062 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/56 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401220 | Dunn |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | Michael G. Dunn (Manalapan, New Jersey) |
| ABSTRACT | Artificial meniscal scaffolds characterized by a composite of circumferential polymer fiber network and orthogonal polymer fiber network embedded in an arcuate bioresorbable matrix comprised of collagen and hyaluronic acid. The orthogonal polymer fiber network prevents separation of the circumferential polymer fiber networks. The polymer fiber networks convert axial compressive forces on the scaffolds to tensile loads on the circumferential polymer fibers. The composite scaffold can be anchored to bone by novel anchoring components that protect the polymer fibers and ensure immediate securement of the artificial meniscal scaffold to bone. |
| FILED | Friday, November 06, 2020 |
| APPL NO | 17/755749 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/30749 (20130101) A61F 2/30756 (20130101) Original (OR) Class A61F 2/30965 (20130101) A61F 2002/3008 (20130101) A61F 2002/30056 (20130101) A61F 2002/30062 (20130101) A61F 2002/30131 (20130101) A61F 2002/30677 (20130101) A61F 2002/30766 (20130101) A61F 2310/00011 (20130101) A61F 2310/00359 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401235 | KARTALOV |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Emil Paskalev KARTALOV (Pacific Grove, California) |
| ABSTRACT | A double-helix weave architecture for an artificial muscle is described. The artificial muscle includes a number of microfluidic channels that are arranged into artificial muscles fibers, where each artificial muscle fiber includes two independent mutually-unconnected microfluidic channels that are entwined in a double helix weave and maintained at opposite electrical polarity. |
| FILED | Tuesday, June 21, 2022 |
| APPL NO | 17/845989 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/741 (20210801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401329 | GIANNESCHI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | Northwestern University (Evanston, Illinois) |
| INVENTOR(S) | Nathan C. GIANNESCHI (Wilmette, Illinois); Claudia BATTISTELLA (Evanston, Illinois) |
| ABSTRACT | Aspects of the invention include a method of treating hair of a subject with an artificial melanin material comprises contacting in a solution artificial melanin precursors with an oxidizing agent at a temperature greater than or equal to 30° C. in the presence of the hair of the subject to form the artificial melanin material; wherein the artificial melanin material associates with the hair of the subject, thereby treating the hair of the subject. Optionally, the contacting step results in deposition of the artificial melanin material on the hair of the subject and/or uptake of the artificial melanin material into the hair of the subject. |
| FILED | Thursday, October 29, 2020 |
| APPL NO | 17/775526 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 8/22 (20130101) A61K 8/41 (20130101) A61K 8/66 (20130101) A61K 8/0241 (20130101) A61K 8/347 (20130101) A61K 8/415 (20130101) A61K 8/445 (20130101) Original (OR) Class A61K 2800/30 (20130101) A61K 2800/95 (20130101) A61K 2800/4324 (20130101) Specific Use of Cosmetics or Similar Toilet Preparations A61Q 5/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401404 | Federoff et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); GEORGETOWN UNIVERSITY (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Howard J. Federoff (Irvine, California); Sudhakar Raja Subramaniam (Irvine, California); Massimo S. Fiandaca (Irvine, California); Mark E. Mapstone (Irvine, California); Xiaomin Su (Washington, District of Columbia) |
| ABSTRACT | Described herein are materials and methods for the treatment of neurodegenerative diseases by administering a combination of fenofibrate and kaempferol. |
| FILED | Wednesday, February 05, 2020 |
| APPL NO | 17/428867 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/13 (20130101) A61K 31/27 (20130101) A61K 31/216 (20130101) A61K 31/352 (20130101) Original (OR) Class A61K 31/428 (20130101) A61K 31/4745 (20130101) A61K 36/82 (20130101) A61K 36/185 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401562 | Brudno et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yevgeny Brudno (Somerville, Massachusetts); Cathal J. Kearney (Boston, Massachusetts); Eduardo Alexandre Barros E Silva (Davis, California); Michael Aizenberg (Cambridge, Massachusetts); Brian Kwee (Gaithersburg, Maryland); Rajiv Desai (San Diego, California); Neel Satish Joshi (Somerville, Massachusetts); David J. Mooney (Sudbury, Massachusetts) |
| ABSTRACT | The present invention provides refillable drug delivery systems, as well as methods of refilling the systems, and methods of using them to treat diseases. |
| FILED | Thursday, January 06, 2022 |
| APPL NO | 17/569720 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/0024 (20130101) A61K 31/704 (20130101) A61K 47/36 (20130101) A61K 47/549 (20170801) Original (OR) Class A61K 47/555 (20170801) A61K 47/6903 (20170801) A61K 49/0021 (20130101) A61K 49/0054 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2310/113 (20130101) C12N 2310/315 (20130101) C12N 2310/351 (20130101) C12N 2320/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401592 | Pomper et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin G. Pomper (Baltimore, Maryland); Wojciech Lesniak (Owings Mills, Maryland); Emad Boctor (Ellicott City, Maryland); Sangeeta Banerjee Ray (Ellicott City, Maryland); Srikanth Boinapally (Baltimore, Maryland); Jeeun Kang (Baltimore, Maryland); Yixuan Wu (Baltimore, Maryland) |
| ABSTRACT | Poly(amidoamine) [PAMAM] dendrimers for use as PSMA-targeted contrast agents for optical and photoacoustic imaging (PA) and theranostic agents for treating prostate cancer are disclosed. |
| FILED | Friday, May 13, 2022 |
| APPL NO | 17/744080 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/60 (20170801) A61K 47/547 (20170801) A61K 49/0032 (20130101) A61K 51/0482 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401621 | Cullen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania); The United States of America as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Kacy Cullen (Media, Pennsylvania); Justin C. Burrell (Philadelphia, Pennsylvania); Joseph Cole Maggiore (Pittsburgh, Pennsylvania) |
| ABSTRACT | In various aspects and embodiments, the present invention provides methods for maintaining motor neuron health in the spinal cord and pro-regenerative capacity of a proximal nerve segment subsequent to a nerve injury in a subject in need thereof, the methods comprising transplanting a stretch-grown tissue engineered nerve graft (TENG) into a proximal site contacting the proximal nerve segment. |
| FILED | Wednesday, November 18, 2020 |
| APPL NO | 17/776829 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/383 (20130101) A61L 27/3633 (20130101) A61L 27/3675 (20130101) Original (OR) Class A61L 27/3834 (20130101) A61L 27/3878 (20130101) A61L 2300/62 (20130101) A61L 2430/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401672 | TRUMBOWER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SPAULDING REHABILITATION HOSPITAL CORPORATION (Charlestown, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Randy D. TRUMBOWER (Charlestown, Massachusetts); Jeremy J. PAPADOPOULOS (Charlestown, Massachusetts); Andrew Q. TAN (Charlestown, Massachusetts); Anthony N. CORSTEN (Charlestown, Massachusetts) |
| ABSTRACT | Systems and methods for hypoxia delivery are provided. An apparatus for providing intermittent normoxia and hypoxia intervals includes a breathing component, a normoxia fluid source, a hypoxia fluid source, a valve, and a control system. The valve is configured to disrupt flow from at least one of the normoxia fluid source and the hypoxia fluid source and the control system is configured to cause the at least one valve to switch between delivery of fluid from the normoxia fluid source and the hypoxia fluid source while maintaining positive pressure at the breathing component. |
| FILED | Monday, October 26, 2020 |
| APPL NO | 17/771328 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 16/06 (20130101) A61M 16/22 (20130101) A61M 16/024 (20170801) Original (OR) Class A61M 16/0045 (20130101) A61M 16/0066 (20130101) A61M 16/0078 (20130101) A61M 16/107 (20140204) A61M 16/125 (20140204) A61M 16/204 (20140204) A61M 16/0833 (20140204) A61M 16/1005 (20140204) A61M 2205/3368 (20130101) A61M 2230/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401709 | BEEBY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Certus Critical Care, Inc. (Salt Lake City, Utah); Wake Forest Unitversity Health Sciences (Winston-Salem, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ruth BEEBY (Santa Clara, California); Cheng-wei PEI (Belmont, California); Myra FABRO (San Francisco, California); David POISNER (Carmichael, California); Patrick Ryan KOLBAY (Salt Lake City, Utah); Daniel FONG (Sacramento, California); Melanie MCWADE (Portland, Oregon); Timothy WILLIAMS (Winston-Salem, North Carolina); Lucas NEFF (Winston-Salem, North Carolina); Michael Austin JOHNSON (Holladay, Utah) |
| ABSTRACT | Methods for performing endovascular procedures are described herein. The methods may comprise advancing an expandable member of a blood flow control device to a target location in a blood vessel of a patient, and rotating a circular gear positioned at least partially within a housing of a controller via the controller communicably coupled to the blood flow control device. Rotating the circular gear may translate a linear gear of a syringe pump fluidly coupled to the expandable member thereby adjusting a volume of the expandable member. Various blood flow control devices, control systems, and fluid delivery systems are also described herein. The fluid delivery systems may include a pump configured for manual or automated delivery of fluids, or configured to switch between automated and manual modes of delivery. The pump may be a syringe pump that utilizes a rack and pinion system, a motor, and a sensor to track the position and/or movement of a component of the syringe pump during fluid transfer. Alternatively, the pump may be a pressure differential pump that includes a flow restrictor and a pressure sensor that controls delivery of fluid from a fluid reservoir. Systems and methods including the syringe and pressure differential pumps are also described. |
| FILED | Thursday, June 16, 2022 |
| APPL NO | 17/842755 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/1204 (20130101) A61B 17/12109 (20130101) A61B 17/12136 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 25/10182 (20131105) Original (OR) Class A61M 25/10188 (20131105) A61M 2205/0238 (20130101) A61M 2205/502 (20130101) A61M 2205/3306 (20130101) A61M 2205/3327 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220402081 | Deluca et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Boeing Company (Chicago, Illinois) |
| ASSIGNEE(S) | The Boeing Company (Chicago, Illinois) |
| INVENTOR(S) | Michael J. Deluca (Norristown, Pennsylvania); Matthew H. Cawthorne (Wayne, Pennsylvania); Howard T. Rolleston (Glen Mills, Pennsylvania) |
| ABSTRACT | A method for repairing a crack in a structure includes mounting a manifold to the structure around the crack. The structure has a nonplanar surface contour that surrounds the crack. The manifold has a base portion, a cover portion, and a plug. The base portion has a grip surface configured to conform to the nonplanar surface contour of the structure. The cover portion is connected to the base portion, and has an injection port and a vent port in fluid communication with a channel aligned to the crack. The injection port transfers a bonding material into and out of the channel. The plug closes and opens the vent port. The method includes filling the channel with the bonding material to direct the bonding material into the crack, and draining the bonding material from the manifold. |
| FILED | Tuesday, February 22, 2022 |
| APPL NO | 17/677036 |
| CURRENT CPC | Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 20/002 (20130101) Metal-working Not Otherwise Provided For; Combined Operations; Universal Machine Tools B23P 6/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220402475 | Shukla et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Oshkosh Defense, LLC (Oshkosh, Wisconsin) |
| ASSIGNEE(S) | Oshkosh Defense, LLC (Oshkosh, Wisconsin) |
| INVENTOR(S) | Deepak Shukla (Oshkosh, Wisconsin); Rongjun Zhang (Neenah, Wisconsin); Nader Nasr (Neenah, Wisconsin) |
| ABSTRACT | A vehicle is operable in three modes of operation. The vehicle includes a first electromagnetic device, a second electromagnetic device electrically coupled to the first electromagnetic device, and an engine coupled to the first electromagnetic device and configured to drive the first electromagnetic device to provide electrical energy. In each of the three modes of operation, whenever the engine drives the first electromagnetic device to provide the electrical energy, the first electromagnetic device operates without providing the electrical energy to an energy storage device. |
| FILED | Monday, April 11, 2022 |
| APPL NO | 17/717295 |
| CURRENT CPC | Arrangement or Mounting of Propulsion Units or of Transmissions in Vehicles; Arrangement or Mounting of Plural Diverse Prime-movers in Vehicles; Auxiliary Drives for Vehicles; Instrumentation or Dashboards for Vehicles; Arrangements in Connection With Cooling, Air Intake, Gas Exhaust or Fuel Supply of Propulsion Units in Vehicles B60K 6/26 (20130101) B60K 6/34 (20130101) B60K 6/52 (20130101) B60K 6/365 (20130101) B60K 6/387 (20130101) B60K 6/445 (20130101) B60K 6/543 (20130101) Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 50/11 (20190201) Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 10/02 (20130101) B60W 10/06 (20130101) B60W 10/08 (20130101) B60W 20/10 (20130101) Original (OR) Class B60W 2510/06 (20130101) B60W 2510/08 (20130101) B60W 2510/081 (20130101) B60W 2510/0604 (20130101) B60W 2510/0638 (20130101) B60W 2520/10 (20130101) B60W 2710/06 (20130101) B60W 2710/08 (20130101) B60W 2710/021 (20130101) B60W 2710/083 (20130101) B60W 2710/0644 (20130101) B60W 2710/0677 (20130101) Indexing Scheme Relating to Aspects Cross-cutting Vehicle Technology B60Y 2200/92 (20130101) B60Y 2300/42 (20130101) B60Y 2300/43 (20130101) B60Y 2300/60 (20130101) B60Y 2300/72 (20130101) B60Y 2400/72 (20130101) B60Y 2400/73 (20130101) Gearing F16H 1/28 (20130101) F16H 3/72 (20130101) F16H 3/727 (20130101) F16H 3/728 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 10/62 (20130101) Y02T 10/92 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 903/91 (20130101) Y10S 903/93 (20130101) Y10S 903/906 (20130101) Y10S 903/914 (20130101) Y10S 903/916 (20130101) Y10S 903/918 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403313 | Varone et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Antonio Varone (Newton, Massachusetts); Norman Wen (Newton, Massachusetts); Daniel Levner (Brookline, Massachusetts); Richard Novak (Jamaica Plain, Massachusetts); Lori McPartlin (North Billerica, Massachusetts); Donald E. Ingber (Boston, Massachusetts); Youngjae Choe (Somerville, Massachusetts); Lian Leng (LaSalle, California); Justin K. Nguyen (Medford, Massachusetts) |
| ABSTRACT | A device for simulating a function of a tissue includes a first structure, a second structure, and a membrane. The first structure defines a first chamber. The first chamber includes a matrix disposed therein and an opened region. The second structure defines a second chamber. The membrane is located at an interface region between the first chamber and the second chamber. The membrane includes a first side facing toward the first chamber and a second side facing toward the second chamber. The membrane separates the first chamber from the second chamber. |
| FILED | Tuesday, August 16, 2022 |
| APPL NO | 17/820174 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5027 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) C12M 23/16 (20130101) Original (OR) Class C12M 25/02 (20130101) C12M 25/14 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/069 (20130101) C12N 5/0629 (20130101) C12N 5/0656 (20130101) C12N 5/0679 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403356 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DUKE UNIVERSITY (Durham, North Carolina); BAYLOR COLLEGE OF MEDICINE (Houston, Texas) |
| ASSIGNEE(S) | DUKE UNIVERSITY (Durham, North Carolina); BAYLOR COLLEGE OF MEDICINE (Houston, Texas) |
| INVENTOR(S) | Qianben Wang (Durham, North Carolina); Fuwen Yuan (Durham, North Carolina); Wei Li (Irvine, California) |
| ABSTRACT | The present disclosure provides a 3′UTR CRISPR-dCas13 Engineering System, and methods of using said system, that allows for the manipulation of the length of 3′untranslated regions by using gRNAs to guide catalytically dead Cas13 to sites upstream and/or downstream of the desired poly adenylation sites. One aspect of the disclosure provides a system for modifying the length a 3′ untranslated region (UTR) of an mRNA transcript. |
| FILED | Monday, July 13, 2020 |
| APPL NO | 17/626561 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/11 (20130101) C12N 15/1135 (20130101) C12N 2310/14 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403367 | WANG |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (NEW YORK, New York) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (NEW YORK, New York) |
| INVENTOR(S) | Harris He WANG (New York, New York) |
| ABSTRACT | The present invention relates to utilizing engineered horizontal gene transfer elements and high-throughput selection strategies to tag and retrieve genetically modified native commensal strains from the mammalian gut. In certain aspects, the present invention relates to methods wherein isolated bacteria from the mammalian gut microbiome that were amenable to genetic manipulation were redeployed back into the mammalian subject as host-optimized engineerable probiotics. |
| FILED | Monday, January 13, 2020 |
| APPL NO | 17/422373 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/74 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 15/102 (20130101) Original (OR) Class C12N 15/1086 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403449 | Song et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| INVENTOR(S) | Chunxiao Song (Oxford, United Kingdom); Stephen R. Quake (Stanford, California); Axel Brunger (Stanford, California); Jiajie Diao (Stanford, California) |
| ABSTRACT | Provided herein is a method for analyzing genomic DNA In some embodiments, the method may comprise labeling a genomic sample by adding a capture tag to the ends of the DNA molecules in the sample and labeling molecules that comprise hydroxymethylcytosine with a first fluorophore, immobilizing the labeled DNA molecules on a support, and imaging individual molecules of hydroxymethylated genomic DNA on the support. |
| FILED | Monday, November 29, 2021 |
| APPL NO | 17/537290 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6818 (20130101) Original (OR) Class C12Q 1/6834 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403453 | Minev et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Dionis Minev (Cambridge, Massachusetts); Christopher Wintersinger (Cambridge, Massachusetts); William M. Shih (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein, in some embodiments, are methods, compositions and kits for controlling nucleation and assembly of molecular nanostructures, microstructures and macrostructures. |
| FILED | Friday, January 14, 2022 |
| APPL NO | 17/576550 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 1/00 (20130101) C07H 21/00 (20130101) C07H 21/04 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6811 (20130101) C12Q 1/6837 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403555 | Jao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rowan University (Glassboro, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dave Jao (Glassboro, New Jersey); Vince Beachley (Medford Lakes, New Jersey) |
| ABSTRACT | In one aspect, the present disclosure provides processes and systems for producing multiple fibers simultaneously, or nearly simultaneously. |
| FILED | Monday, June 13, 2022 |
| APPL NO | 17/838948 |
| CURRENT CPC | Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 4/02 (20130101) Original (OR) Class D01D 4/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403973 | Donatelli et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | APG VISION LLC (Allison Park, Pennsylvania) |
| ASSIGNEE(S) | APG VISION LLC (Allison Park, Pennsylvania) |
| INVENTOR(S) | Gregory M. Donatelli (Hatboro, Pennsylvania); Christopher C. McGeary (Gibsonia, Pennsylvania); Tyler William Dulaney (Greenville, Pennsylvania) |
| ABSTRACT | A clamping mechanism configured to be attachable to a mounting base and to support a ball mount between the clamping mechanism and the mounting base. The clamping mechanism comprising a first-end portion configured to be attached to the mounting base, the first-end portion including a tab, a flexible section, a first bottom surface that extends in a first plane, and a first through hole extending through the tab and the first bottom surface; a second-end portion configured such that a bend allowance of the second-end portion is less than a bend allowance of the first-end portion, the second-end portion including a second bottom surface that extends in a second plane, and a second through hole extending through the second bottom surface; and a contoured surface configured to cradle a body portion of the ball mount. |
| FILED | Friday, June 10, 2022 |
| APPL NO | 17/837212 |
| CURRENT CPC | Frames, Casings or Beds of Engines, Machines or Apparatus, Not Specific to Engines, Machines or Apparatus Provided for Elsewhere; Stands; Supports F16M 11/14 (20130101) F16M 13/005 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220404055 | Ginsberg |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America as Represented by The Secretary of The Army (Alexandria, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark D. Ginsberg (Champaign, Illinois) |
| ABSTRACT | In one embodiment, a ventilation control system includes a processor; a memory; a calculation module to calculate an inverse protection factor for a structure using a lumped element model, the inverse protection factor being an inverse of a protection factor which is a ratio of contaminant which the one or more infected individuals exhale in the structure and contaminant which the uninfected individual inhales in the structure; and a ventilation control module to control a ventilation system to modify air flowing in the structure. The inverse protection factor is calculated based on operating parameters of the ventilation system, arrangement of spaces of the structure, and locations and relative positions of the infected and uninfected individuals in the structure with respect to air flowing in the structure and influenced by the ventilation system. The ventilation control module is configured to control the ventilation system based on the calculated inverse protection factor. |
| FILED | Wednesday, June 16, 2021 |
| APPL NO | 17/349475 |
| CURRENT CPC | Air-conditioning; Air-humidification; Ventilation; Use of Air Currents for Screening F24F 11/0001 (20130101) F24F 11/63 (20180101) Original (OR) Class F24F 11/74 (20180101) F24F 2120/12 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220404204 | Hanus et al. |
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| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Riley Hanus (Atlanta, Georgia); Samuel Graham, Jr. (Atlanta, Georgia) |
| ABSTRACT | Disclosed herein are thermoreflectance enhancement coatings and methods of making and use thereof. |
| FILED | Friday, April 15, 2022 |
| APPL NO | 17/721695 |
| CURRENT CPC | Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/26 (20130101) C09D 7/65 (20180101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/0623 (20130101) Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 5/0007 (20130101) Original (OR) Class G01J 5/80 (20220101) G01J 5/0896 (20130101) G01J 2005/0077 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/55 (20130101) G01N 21/1717 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0226 (20130101) H01L 21/02568 (20130101) H01L 21/02617 (20130101) H01L 29/2003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220404305 | Kantack et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas R. Kantack (Cambridge, Massachusetts); Jennifer S. Benzing (Baltimore, Maryland); Tessa B. VanVolkenburg (Ellicott City, Maryland); Zhiyong Xia (Rockville, Maryland); Spencer A. Langevin (Columbia, Maryland); Daniel S. Ayoub (Columbia, Maryland) |
| ABSTRACT | A sensor for measuring ocean water salinity is described. The sensor may include a measurement clock circuit, a control clock circuit, and a comparator circuit. The measurement clock circuit, having an output that varies with salinity of a fluid, may have a first circuit architecture that includes a capacitive gap assembly that permits a fluid to flow into a gap between two electrodes of the capacitive gap assembly. The control clock circuit, having an output that does not vary with salinity of the fluid, may have a second circuit architecture comprising a capacitor. The comparator circuit may be configured to compare the controlled clock output to the measured clock output over a duration of time to determine a salinity measurement of the fluid. The first circuit architecture may differ from the second circuit architecture in that an electrically connected position of the capacitive gap assembly within the first circuit architecture is the electrically connected position of the capacitor within the second circuit architecture. |
| FILED | Tuesday, February 15, 2022 |
| APPL NO | 17/671809 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/226 (20130101) Original (OR) Class G01N 33/18 (20130101) Electric Digital Data Processing G06F 1/10 (20130101) Pulse Technique H03K 5/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220404308 | Mirica et al. |
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| FUNDED BY |
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| APPLICANT(S) | Trustees of Dartmouth College (Hanover, New Hampshire) |
| ASSIGNEE(S) | Trustees of Dartmouth College (Hanover, New Hampshire) |
| INVENTOR(S) | Katherine A. Mirica (Honover, New Hampshire); Lukasz Mendecki (White Rever Juction, Vermont); Priyanshu Chandra (Hanover, New Hampshire) |
| ABSTRACT | Embodiments of the present disclosure pertain to methods of capturing one or more ions from an environment by associating the environment with a composition that includes a metal-organic framework. The association results in the capture of the one or more ions by the metal-organic framework. The metal-organic frameworks may include a plurality of metals and a plurality of triphenylene-based ligands that interconnect the plurality of the metals. The methods of the present disclosure may also include a step of detecting one or more captured ions. Additional embodiments of the present disclosure pertain to the compositions for capturing one or more ions from an environment. |
| FILED | Wednesday, August 17, 2022 |
| APPL NO | 17/889985 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/226 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/333 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220404337 | Nargi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Frances Nargi (Littleton, Massachusetts); Scott Thomas Wick (Ayer, Massachusetts); Deepak Mishra (Cambridge, Massachusetts) |
| ABSTRACT | The invention relates to compositions and methods for making and use of a real-time cellular sensor. Components of a multipart enzyme are sequestered in different cellular compartments and only come together after receptor activation; a pool of substrate is made available in the cell to ensure real-time enzymatic output. |
| FILED | Thursday, April 21, 2022 |
| APPL NO | 17/726326 |
| CURRENT CPC | Peptides C07K 14/66 (20130101) C07K 14/721 (20130101) C07K 14/723 (20130101) C07K 2319/03 (20130101) C07K 2319/09 (20130101) C07K 2319/50 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0071 (20130101) C12N 15/625 (20130101) Enzymes C12Y 114/14003 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5023 (20130101) Original (OR) Class G01N 2333/726 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220404453 | SMITH |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Assured Information Security, Inc. (Rome, New York) |
| ASSIGNEE(S) | Assured Information Security, Inc. (Rome, New York) |
| INVENTOR(S) | Jason Eric SMITH (Oneida, New York) |
| ABSTRACT | Geolocating one or more emitters includes obtaining a set of lines of bearing (LOBs) indicative of location(s) of emitter(s), determining intersections of LOBs of the set and generating clusters informed by those intersections, assigning the LOBs of the set to cluster(s) based on proximity, identifying a cluster having the greatest number of assigned LOBs from the set; determining an emitter location area based on a best point estimate for the cluster, and indicating a location of an emitter as the emitter location area. Additional emitters can be located by removing from the set of LOBs those LOBs assigned to the identified cluster, and repeating aforementioned aspects. Initially, the set of LOBs can be selected from a larger collection as a representative subset thereof. |
| FILED | Thursday, December 10, 2020 |
| APPL NO | 17/281835 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 5/0205 (20130101) G01S 5/0249 (20200501) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220404458 | Ranney et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | U.S. Army Combat Capabilities Development Command, Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenneth I. Ranney (Rockville, Maryland); William J. Diehl (Annandale, Virginia); Kwok Foo Tom (Washington, District of Columbia); Dannielle Tadas (Germantown, Maryland); Neal Tesny (Ellicott City, Maryland); Andre C. Magill (Fairfax, Virginia) |
| ABSTRACT | Method and apparatus for detecting and characterizing a pulse sequence using a finite impulse filter to determine a pulse width (PW) of pulses within the pulse sequence. The method and apparatus may also apply a histogram to the filtered pulses to determine the pulse rate interval (PRI) of pulses in the pulse sequence. |
| FILED | Wednesday, April 06, 2022 |
| APPL NO | 17/714177 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/285 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220404466 | Jones et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Kansas (Lawrence, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christian Curtis Jones (Manhattan, Kansas); Lumumba Harnett (Lawrence, Kansas); Charles Andrew Mohr (Beavercreek, Ohio); Shannon David Blunt (Shawnee, Kansas) |
| ABSTRACT | The present application provides techniques for reducing noise in sensor-based systems, such as radar systems. In particular, techniques referred to background supplemental cancellation (BaSC) and background supplemental loading (BaSL) are disclosed and facilitate improved detection of moving targets in certain types of radar systems, such as radar systems based on Reiterative minimum-mean square error (RMMSE) estimation formulations. The BaSC technique may utilize a hard cancellation, where clutter cancellation is performed prior to estimation, while the BaSL technique may utilize a “soft” cancellation technique whereby clutter cancellation is performed jointly with estimation. The clutter cancellation provided via the BaSC and BaSL techniques improves the accuracy of the radar system with respect to performing target detection. |
| FILED | Monday, February 28, 2022 |
| APPL NO | 17/682973 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/414 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220404485 | Hester et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| INVENTOR(S) | Jimmy Georges Donald Hester (Atlanta, Georgia); Emmanouil M. Tentzeris (Atlanta, Georgia) |
| ABSTRACT | A system for using thin and energy-autonomous backscatter tags and corresponding sensing nodes may operate with 24 GHz backscatter reflectarray tags having low power consumption. A digital beam steering, frequency-modulated continuous wave (FMCW) radar may be used for detection, localization, identification and communications. The tags may include environmental sensors that are used to modulate backscatter waves for data communications directed to a reader or may digitally modulate the backscatter transmissions without sensor data for independent localization of each tag in a network. |
| FILED | Wednesday, August 24, 2022 |
| APPL NO | 17/894610 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/025 (20130101) G01S 13/758 (20130101) Original (OR) Class G01S 13/825 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 7/10168 (20130101) Antennas, i.e Radio Aerials H01Q 3/2647 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220405537 | YANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Robert Bosch GmbH (Stuttgart, Germany) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karren YANG (Medford, Pennsylvania); Wan-Yi LIN (Wexford, Pennsylvania); Manash PRATIM (Pittsburgh, Pennsylvania); Filipe J. CABRITA CONDESSA (Pittsburgh, Pennsylvania); Jeremy KOLTER (Pittsburgh, Pennsylvania) |
| ABSTRACT | A multimodal perception system for an autonomous vehicle includes a first sensor that is one of a video, RADAR, LIDAR, or ultrasound sensor, and a controller. The controller may be configured to, receive a first signal from a first sensor, a second signal from a second sensor, and a third signal from a third sensor, extract a first feature vector from the first signal, extract a second feature vector from the second signal, extract a third feature vector from the third signal, determine an odd-one-out vector from the first, second, and third feature vectors via an odd-one-out network of a machine learning network, based on inconsistent modality prediction, fuse the first, second, and third feature vectors and odd-one-out vector into a fused feature vector, output the fused feature vector, and control the autonomous vehicle based on the fused feature vector. |
| FILED | Wednesday, June 16, 2021 |
| APPL NO | 17/349665 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/629 (20130101) G06K 9/00791 (20130101) G06K 9/6293 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Image Data Processing or Generation, in General G06T 7/246 (20170101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220405648 | LIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Robert Bosch GmbH (Stuttgart, Germany) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wan-Yi LIN (Wexford, Pennsylvania); Leonid BOYTSOV (Pittsburgh, Pennsylvania); Mohammad Sadegh NOROUZZADEH (Pittsburgh, Pennsylvania); Jeremy KOLTER (Pittsburgh, Pennsylvania); Filipe J. CABRITA CONDESSA (Pittsburgh, Pennsylvania) |
| ABSTRACT | A computer-implemented method for training a machine-learning network. The method includes receiving an input data from a sensor, wherein the input data is indicative of image, radar, sonar, or sound information, generating an input data set utilizing the input data, wherein the input data set includes perturbed data, sending the input data set to a robustifier, wherein the robustifier is configured to clean the input data set by removing perturbations associated with the input data set to create a modified input data set, sending the modified input data set to a pretrained machine learning task, training the robustifier to obtain a trained robustifier utilizing the modified input data set, and in response to convergence of the trained robustifier to a first threshold, output the trained robustifier. |
| FILED | Wednesday, June 16, 2021 |
| APPL NO | 17/349645 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6256 (20130101) G06K 9/6262 (20130101) Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/08 (20130101) G06N 20/20 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220405918 | Madabhushi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio); The United States Government as Represented by The Department of Veteran Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anant Madabhushi (Shaker Heights, Ohio); Sepideh Azarianpour Esfahani (Cleveland Heights, Ohio); Haider Mahdi (Wexford, Pennsylvania) |
| ABSTRACT | Various embodiments of the present disclosure are directed towards a method for generating a risk group classification for an African American (AA) patient. The method includes extracting a first plurality of architectural features from a digitized H&E slide image of the AA patient. A risk score for the AA patient is generated based on the first plurality of architectural features, where the risk score is prognostic of overall survival (OS) of the AA patient. The risk group classification is generated for the AA patient, where generating the risk group classification includes classifying the AA patient into either a high risk group or a low risk group based on the risk score, where the high risk group indicates the AA patient will die before a threshold date and the low risk group indicates the AA patient will die after or on the threshold date. |
| FILED | Tuesday, February 15, 2022 |
| APPL NO | 17/671882 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 2207/30024 (20130101) G06T 2207/30096 (20130101) Image or Video Recognition or Understanding G06V 10/764 (20220101) G06V 10/774 (20220101) G06V 20/698 (20220101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220405931 | Madabhushi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anant Madabhushi (Shaker Heights, Ohio); Cheng Lu (Cleveland Heights, Ohio) |
| ABSTRACT | Embodiments include accessing an image of a region of tissue demonstrating cancerous pathology; detecting a plurality of cells represented in the image; segmenting a cellular nucleus of a first member of the plurality of cells and a cellular nucleus of at least one second, different member of the plurality of cells; extracting a set of nuclear morphology features from the plurality of cells; constructing a feature driven local cell graph (FeDeG) based on the set of nuclear morphology features and a spatial relationship between the cellular nuclei using a mean-shift clustering approach; computing a set of FeDeG features based on the FeDeG; providing the FeDeG features to a machine learning classifier; receiving, from the machine learning classifier, a classification of the region of tissue as a long-term or a short-term survivor, based, at least in part, on the set of FeDeG features; and displaying the classification. |
| FILED | Friday, August 26, 2022 |
| APPL NO | 17/896454 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 2207/10056 (20130101) G06T 2207/20081 (20130101) G06T 2207/30024 (20130101) G06T 2207/30061 (20130101) G06T 2207/30096 (20130101) Image or Video Recognition or Understanding G06V 20/698 (20220101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 40/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220406056 | Ewing et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MICHIGAN TECHNOLOGICAL UNIVERSITY (Houghton, Michigan); U.S. Army DEVCOM Ground Vehicle Systems Center (GVSC) (Warren, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jordan Ewing (Warren, Pennsylvania); Thomas Oommen (Houghton, Michigan); Russell Alger (Calumet, Michigan); Paramsothy Jayakumar (Warren, Michigan) |
| ABSTRACT | Methods for characterizing soil stiffness of an area. One example method includes receiving, with an electronic processor, a parameter corresponding to a soil type of the area; receiving, with the electronic processor, a plurality of thermal images of the area; determining, with the electronic processor, an apparent thermal inertia of the area based on the plurality of thermal images; determining, with the electronic processor, a soil gradation of the area based on the parameter; determining, with a machine learning algorithm executed by the electronic processor, an approximate soil stiffness of the area based on the apparent thermal inertia; and outputting, to a display communicatively coupled to the electronic processor, a representation of the approximate soil stiffness. |
| FILED | Thursday, March 17, 2022 |
| APPL NO | 17/697158 |
| CURRENT CPC | Image or Video Recognition or Understanding G06V 10/14 (20220101) G06V 10/766 (20220101) G06V 20/194 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220406213 | Warren et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BETA AIR, LLC (South Burlington, Vermont) |
| ASSIGNEE(S) | BETA AIR, LLC (SOUTH BURLINGTON, Vermont) |
| INVENTOR(S) | Nicholas Granger Warren (Burlington, Vermont); Charles C. Guthrie (Burlington, Vermont); Nicholas Moy (Burlington, Vermont); Alexander Hoekje List (South Burlington, Vermont) |
| ABSTRACT | Aspects relate to augmented reality (AR) methods and systems for simulated operation of an electric vertical take-off and landing (eVTOL) aircraft. An exemplary AR system includes at least an aircraft component of an eVTOL aircraft, a computing device configured to operate a flight simulator to simulate flight in an environment and simulate at least a virtual representation interactive with the flight simulator, where the at least a virtual representation includes an aircraft digital twin of the at least an aircraft component, and a mesh network configured to communicatively connect the at least an aircraft component and the computing device and communicate encrypted data. |
| FILED | Wednesday, June 16, 2021 |
| APPL NO | 17/348916 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 19/006 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 9/24 (20130101) G09B 9/165 (20130101) Original (OR) Class G09B 9/206 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220406407 | RAJAPAKSE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| INVENTOR(S) | Indika RAJAPAKSE (Ann Arbor, Michigan); Stephen LINDSLY (Ann Arbor, Michigan); Can CHEN (Ann Arbor, Michigan) |
| ABSTRACT | A method is presented for analyzing interactions in a human genome. The method includes: receiving a biological sample of a cell from a subject; extracting read data from the biological sample, where the read data includes a set of reads; and constructing, by a computer processor, a hypergraph from the read data, where each node in the hypergraph represents a locus and hyperedges in the hypergraph represent interactions between two or more loci. The hypergraphs may be used for different applications including determining entropy, comparing different biological samples and reporting multi-way contacts in a set of transcription clusters. |
| FILED | Tuesday, June 14, 2022 |
| APPL NO | 17/839937 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/30 (20190201) Original (OR) Class G16B 25/00 (20190201) G16B 45/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220406591 | Nepal et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Neeraj Nepal (Woodbridge, Virginia); Charles R. Eddy, JR. (Columbia, Maryland); Nadeemullah A. Mahadik (Springfield, Virginia); Syed B. Qadri (Fairfax Station, Virginia); Michael J. Mehl (Davidsonville, Maryland) |
| ABSTRACT | Described herein is a method for growing indium nitride (InN) materials by growing hexagonal InN using a pulsed growth method at a temperature lower than 300° C. |
| FILED | Wednesday, August 03, 2022 |
| APPL NO | 17/879825 |
| CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 25/02 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0242 (20130101) H01L 21/0254 (20130101) Original (OR) Class H01L 21/0262 (20130101) H01L 21/02381 (20130101) H01L 21/02433 (20130101) H01L 21/02458 (20130101) H01L 21/02661 (20130101) H01L 29/2003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220406952 | Polly et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Stephen Polly (Rochester, New York); Julia D'Rozario (Rochester, New York); George Nelson (Champaign, Illinois); Seth Hubbard (Pittsford, New York) |
| ASSIGNEE(S) | Rochester Institute of Technology (Rochester, New York) |
| INVENTOR(S) | Stephen Polly (Rochester, New York); Julia D'Rozario (Rochester, New York); George Nelson (Champaign, Illinois); Seth Hubbard (Pittsford, New York) |
| ABSTRACT | A reflector including a substrate and a plurality of alternating layers of two materials having different indices of refraction disposed on the substrate, wherein the reflector exhibits a central peak in reflectance vs wavelength and the reflectance of the high-energy side-lobes is increased in intensity and the reflectance of the low-energy side-lobes is reduced in intensity and method for making the reflector is disclosed. |
| FILED | Friday, June 17, 2022 |
| APPL NO | 17/807549 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/056 (20141201) H01L 31/184 (20130101) H01L 31/0547 (20141201) H01L 31/0693 (20130101) H01L 31/06875 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220406985 | Majkic et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Houston System (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Goran Majkic (Houston, Texas); Venkat Selvamanickam (Houston, Texas) |
| ABSTRACT | A superconductor tape and method for manufacturing, measuring, monitoring, and controlling same are disclosed. Embodiments are directed to a superconductor tape which includes a superconductor film overlying a buffer layer which overlies a substrate. In one embodiment, the superconductor film is defined as having a c-axis lattice constant higher than 11.74 Angstroms. In another embodiment, the superconductor film comprises BaMO3, where M=Zr, Sn, Ta, Nb, Hf, or Ce, and which has a (101) peak of BaMO3 elongated along an axis that is between 60° to 90° from an axis of the (001) peaks of the superconductor film. These and other embodiments achieve well-aligned nanocolumnar defects and thus a high lift factor, which can result in superior critical current performance of the tape in, for example, high magnetic fields. |
| FILED | Friday, July 15, 2022 |
| APPL NO | 17/865763 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 39/126 (20130101) H01L 39/143 (20130101) H01L 39/2441 (20130101) H01L 39/2461 (20130101) Original (OR) Class Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 40/60 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220406986 | Majkic et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Houston System (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Goran Majkic (Houston, Texas); Venkat Selvamanickam (Houston, Texas) |
| ABSTRACT | A superconductor tape and method for manufacturing, measuring, monitoring, and controlling same are disclosed. Embodiments are directed to a superconductor tape which includes a superconductor film overlying a buffer layer which overlies a substrate. In one embodiment, the superconductor film is defined as having a c-axis lattice constant higher than 11.74 Angstroms. In another embodiment, the superconductor film comprises BaMO3, where M=Zr, Sn, Ta, Nb, Hf, or Ce, and which has a (101) peak of BaMO3 elongated along an axis that is between 60° to 90° from an axis of the (001) peaks of the superconductor film. These and other embodiments achieve well-aligned nanocolumnar defects and thus a high lift factor, which can result in superior critical current performance of the tape in, for example, high magnetic fields. |
| FILED | Friday, July 15, 2022 |
| APPL NO | 17/865860 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 39/126 (20130101) H01L 39/143 (20130101) H01L 39/2441 (20130101) H01L 39/2461 (20130101) Original (OR) Class Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 40/60 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20220407001 — Novel Nanocomposite Phase-Change Memory Materials and Design and Selection of the Same
| US 20220407001 | Takeuchi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland); University of Washington (Seattle, Washington); Government of the United States of America as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ichiro Takeuchi (Laurel, Maryland); Heshan Yu (Greenbelt, Maryland); Changming Wu (Seattle, Washington); Mo Li (Seattle, Washington); Aaron Gilad Kusne (Rockville, Maryland) |
| ABSTRACT | Provided herein are novel materials, such as novel phase-change memory materials providing superior characteristics, and methods of discovering/selecting such novel materials via machine learning, such as Bayesian active learning. An exemplary material provided by the inventive concept is the nanocomposite phase-change memory material Ge4Sb6Te7, selected using closed-loop autonomous materials exploration and optimization (CAMEO). |
| FILED | Tuesday, February 22, 2022 |
| APPL NO | 17/651946 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/2472 (20130101) H01L 45/06 (20130101) H01L 45/16 (20130101) H01L 45/144 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220407088 | Sankarasubramanian et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shrihari Sankarasubramanian (St. Louis, Missouri); Zhongyang Wang (St. Louis, Missouri); Vijay K. Ramani (St. Louis, Missouri) |
| ABSTRACT | Described herein are flow field plates comprising a flow field pattern and fuel cells comprising the flow field plates comprising a flow field pattern. The flow field plates and fuel cells are applicable to fuel cells and stacks over a range of sizes and fuel/oxidant combinations as long as the fuel and oxidant are incompressible liquids. |
| FILED | Monday, June 13, 2022 |
| APPL NO | 17/806622 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/22 (20130101) H01M 8/0258 (20130101) Original (OR) Class H01M 2250/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220407221 | Taylor et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America as represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin J. Taylor (Escondido, California); Teresa H. Emery (San Diego, California) |
| ABSTRACT | An antenna comprising; a substrate; a continuous film of yttrium barium copper oxide (YBCO) disposed on the substrate having first and second regions, wherein the first region has a first oxygen doping level and wherein the second region has a second oxygen doping level that is different from the first oxygen doping level; a nano-scale conductive structure, shaped to resonate at a terahertz (THz) frequency, disposed on a boundary between the first and second regions; and a conductive path electrically connected to the first and second regions and to the conductive structure such that induced current in the structure due to incoming THz radiation heats the boundary thereby creating a thermal gradient, which results in the generation of Seebeck effect voltage. |
| FILED | Tuesday, June 22, 2021 |
| APPL NO | 17/355005 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 35/32 (20130101) H01L 39/14 (20130101) Antennas, i.e Radio Aerials H01Q 1/364 (20130101) Original (OR) Class H01Q 23/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220407453 | Bermel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter Andrew Bermel (West Lafayette, Indiana); David Jonathan Kortge (West Lafayette, Indiana); Ze Wang (West Lafayette, Indiana); Zhiguang Zhou (San Jose, California); Jie Zhu (West Lafayette, Indiana) |
| ABSTRACT | A radiatively cooled solar array, including a downwardly-facing solar cell and a mirror positioned below the solar cell and oriented to direct sunlight onto the solar cell. The assembly also includes a heat sink in thermal communication with the solar cell and disposed opposite the mirror. The heat sink is in radiative communication through Earth's atmosphere with outer space. |
| FILED | Wednesday, January 26, 2022 |
| APPL NO | 17/585470 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/052 (20130101) Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 40/22 (20141201) H02S 40/42 (20141201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220407763 | Giannakis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Georgios B. Giannakis (Minnetonka, Minnesota); Xiaoli Ma (Auburn, Alabama) |
| ABSTRACT | Techniques are described for carrier frequency offset (CFO) and channel estimation of orthogonal frequency division multiplexing (OFDM) transmissions over multiple-input multiple-output (MIMO) frequency-selective fading channels. A wireless transmitter forms blocks of symbols by inserting training symbols within two or more blocks of information-bearing symbols. The transmitter applies a hopping code to each of the blocks of symbols to insert a null subcarrier at a different position within each of the blocks of symbols, and a modulator outputs a wireless signal in accordance with the blocks of symbols. A receiver receives the wireless signal and estimates the CFO, and outputs a stream of estimated symbols based on the estimated CFO. |
| FILED | Wednesday, April 06, 2022 |
| APPL NO | 17/714926 |
| CURRENT CPC | Transmission H04B 7/046 (20130101) H04B 7/063 (20130101) H04B 7/066 (20130101) H04B 7/0413 (20130101) Multiplex Communication H04J 11/0063 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 5/0016 (20130101) H04L 25/0202 (20130101) H04L 25/0206 (20130101) H04L 25/0228 (20130101) H04L 25/0242 (20130101) H04L 27/2607 (20130101) H04L 27/2613 (20130101) H04L 27/2626 (20130101) Original (OR) Class H04L 27/2657 (20130101) H04L 27/2671 (20130101) H04L 27/2672 (20130101) H04L 27/2675 (20130101) H04L 27/2692 (20130101) H04L 27/2695 (20130101) H04L 27/26134 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220407780 | Szymanski et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Boleslaw Karol Szymanski (Loudonville, New York); Amr Elsisy (Troy, New York); Aamir Mandviwalla (Troy, New York) |
| ASSIGNEE(S) | Rensselaer Polytechnic Institute (Troy, New York) |
| INVENTOR(S) | Boleslaw Karol Szymanski (Loudonville, New York); Amr Elsisy (Troy, New York); Aamir Mandviwalla (Troy, New York) |
| ABSTRACT | A method of generating a synthetic network includes receiving, by a group structure identification module, anonymized input data related to an original network. The anonymized input data includes an anonymized list of nodes, a list of edges and a list of groups. The method further includes determining, by the group structure identification module, for each pair of nodes, a probability of an edge between the pair of nodes. A resulting list of probabilities corresponds to a summary group structure. The method further includes generating, by a synthetic random network generation module, at least one synthetic random network based, at least in part, on the determined probabilities. |
| FILED | Wednesday, March 30, 2022 |
| APPL NO | 17/708212 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 41/12 (20130101) Original (OR) Class H04L 41/044 (20130101) H04L 41/145 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220407891 | Albanese et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Palo Alto Research Center Incorporated (Palo Alto, California) |
| ASSIGNEE(S) | Palo Alto Research Center Incorporated (Palo Alto, California) |
| INVENTOR(S) | Massimiliano Albanese (Potomac, Maryland); Marc E. Mosko (Santa Cruz, California) |
| ABSTRACT | A system is provided for determining vulnerability metrics for graph-based configuration security. During operation, the system generates a multi-layer graph for a system with a plurality of interconnected components. The system determines, based on the multi-layer subgraph, a model for a multi-step attack on the system by: calculating, based on a first set of variables and a first set of tunable parameters, a likelihood of exploiting a vulnerability in the system; and calculating, based on a second set of variables and a second set of tunable parameters, an exposure factor indicating an impact of exploiting a vulnerability on the utility of an associated component. The system determines, based on the model, a set of attack paths that can be used in the multi-step attack and recommends a configuration change in the system, thereby facilitating optimization of system security to mitigate attacks on the system while preserving system functionality. |
| FILED | Thursday, June 17, 2021 |
| APPL NO | 17/350221 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 63/205 (20130101) Original (OR) Class H04L 63/1433 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220407920 | Dinan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NVIDIA Corporation (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Dinan (Sharon, Massachusetts); Akhil Langer (Savoy, Illinois); Sreeram Potluri (Milpitas, California) |
| ABSTRACT | Apparatuses, systems, and techniques are directed to automatic coalescing of GPU-initiated network communications. In one method, a communication engine receives, from a shared memory application executing on a first graphics processing unit (GPU), a first communication request assigned to or having a second GPU as a destination to be processed. The communication engine determines that the first communication request satisfies a coalescing criterion and stores the first communication request in association with a group of requests that have a common property. The communication engine coalesces the group of requests into a coalesced request and transports the coalesced request to the second GPU over a network. |
| FILED | Thursday, June 17, 2021 |
| APPL NO | 17/351002 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 67/12 (20130101) H04L 67/104 (20130101) H04L 67/141 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220408542 | Hegelich et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bjorn Manuel Hegelich (Austin, Texas); Constantin Aniculaesei (Austin, Texas) |
| ABSTRACT | Disclosed herein are particle-assisted wakefield electron acceleration devices, accelerated electrons generated using said devices, and methods of use thereof. |
| FILED | Tuesday, June 21, 2022 |
| APPL NO | 17/845223 |
| CURRENT CPC | Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 15/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20220401558 | Noy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); UNIVERSIDAD DEL PAÍS VASCO (Leioa, Spain) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aleksandr Noy (San Carlos, California); Jia Geng (Ruzhou, China PRC); Jianfei Zhang (Merced, California); Vadim Frolov (Leioa, Spain) |
| ABSTRACT | Provided herein is a nanopore structure, which in one aspect is a “carbon nanotube porin”, that comprises a short nanotube with an associated lipid coating. Also disclosed are compositions and methods enabling the preparation of such nanotube/lipid complexes. Further disclosed is a method for therapeutics delivery that involves a drug delivery agent comprising a liposome with a NT loaded with a therapeutic agent, introducing the therapeutic agent into a cell or a tissue or an organism; and subsequent release of the therapeutic agents into a cell. |
| FILED | Wednesday, August 17, 2022 |
| APPL NO | 17/890056 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 25/04 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0092 (20130101) A61K 9/1272 (20130101) A61K 47/02 (20130101) Original (OR) Class Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/08 (20130101) B01J 13/20 (20130101) B01J 13/203 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 15/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 21/064 (20130101) C01B 32/17 (20170801) C01B 32/172 (20170801) C01B 32/174 (20170801) C01B 32/176 (20170801) C01B 2202/02 (20130101) C01B 2202/34 (20130101) C01B 2202/36 (20130101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 39/06 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2004/04 (20130101) C01P 2004/13 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6825 (20130101) C12Q 1/6869 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/44791 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401913 | KIM et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Mo-Sci Corporation (Rolla, Missouri); The Curators of the Unieristy of Missouri (Rolla, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cheol-Woon KIM (Rolla, Missouri); Richard K. BROW (Rolla, Missouri); Jen-Hsien HSU (Keller, Texas) |
| ABSTRACT | A silver-doped, nano-porous hydroxyapatite material is provided that can be utilized to capture radioactive iodine, 129I. Methods of using the silver-doped, nano-porous hydroxyapatite material to remove radioactive iodine, and methods of manufacturing the material are also provided. |
| FILED | Tuesday, July 05, 2022 |
| APPL NO | 17/857388 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/048 (20130101) Original (OR) Class B01J 20/2808 (20130101) B01J 20/3021 (20130101) B01J 20/3078 (20130101) B01J 20/3085 (20130101) B01J 20/28004 (20130101) B01J 20/28019 (20130101) Non-metallic Elements; Compounds Thereof; C01B 25/32 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/54 (20130101) C01P 2002/72 (20130101) C01P 2004/02 (20130101) C01P 2004/03 (20130101) C01P 2004/32 (20130101) C01P 2004/61 (20130101) C01P 2006/16 (20130101) Protection Against X-radiation, Gamma Radiation, Corpuscular Radiation or Particle Bombardment; Treating Radioactively Contaminated Material; Decontamination Arrangements Therefor G21F 9/02 (20130101) G21F 9/12 (20130101) G21F 9/16 (20130101) G21F 9/162 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401917 | Ellebracht et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nathan C. Ellebracht (Oakland, California); Sarah E. Baker (Dublin, California); Eric B. Duoss (Dublin, California); Simon Hoching Pang (Fremont, California); Joshuah K. Stolaroff (Oakland, California) |
| ABSTRACT | A porous sorbent ceramic product includes a three-dimensional structure having an electrically conductive ceramic material, wherein the conductive ceramic material has an open cell structure with a plurality of intra-material pores, a sorbent additive primarily present in the intra-material pores of the conductive ceramic material for adsorption of a gas, and at least two electrodes in electrical communication with the conductive ceramic material. |
| FILED | Wednesday, June 16, 2021 |
| APPL NO | 17/349574 |
| CURRENT CPC | Separation B01D 53/62 (20130101) B01D 53/82 (20130101) B01D 53/96 (20130101) B01D 2253/202 (20130101) B01D 2257/504 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/0251 (20130101) B01J 20/262 (20130101) Original (OR) Class B01J 20/3007 (20130101) B01J 20/3078 (20130101) B01J 20/3204 (20130101) B01J 20/3272 (20130101) B01J 20/3293 (20130101) B01J 20/3425 (20130101) B01J 20/3441 (20130101) B01J 20/28011 (20130101) B01J 20/28023 (20130101) B01J 20/28059 (20130101) B01J 20/28061 (20130101) B01J 20/28085 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/50 (20170801) C01B 2210/0007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401941 | Moulton et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Staci A. Moulton (Broomfield, Colorado); Alan W. Weimer (Niwot, Colorado) |
| ABSTRACT | Structures, catalysts, and reactors suitable for use for a variety of applications, including gas-to-liquid and coal-to-liquid processes and methods of forming the structures, catalysts, and reactors are disclosed. The catalyst material can be deposited onto an inner wall of a microtubular reactor and/or onto porous support structures using atomic layer deposition techniques. |
| FILED | Friday, August 19, 2022 |
| APPL NO | 17/891898 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/0093 (20130101) B01J 23/75 (20130101) B01J 35/006 (20130101) B01J 35/0013 (20130101) B01J 35/023 (20130101) B01J 35/1014 (20130101) B01J 37/08 (20130101) B01J 37/34 (20130101) B01J 37/0221 (20130101) Original (OR) Class B01J 2219/00792 (20130101) B01J 2219/00801 (20130101) B01J 2219/00835 (20130101) Cracking Hydrocarbon Oils; Production of Liquid Hydrocarbon Mixtures, e.g by Destructive Hydrogenation, Oligomerisation, Polymerisation; Recovery of Hydrocarbon Oils From Oil-shale, Oil-sand, or Gases; Refining Mixtures Mainly Consisting of Hydrocarbons; Reforming of Naphtha; Mineral Waxes C10G 2/33 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220402027 | KING et al. |
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| FUNDED BY |
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| APPLICANT(S) | Forge Nano, Inc. (Thornton, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David M. KING (Sudbury, Massachusetts); Paul LICHTY (Louisville, Colorado) |
| ABSTRACT | The present invention provides various passive electronic components comprising a layer of coated particles, and methods for producing and using the same. Some of the passive electronic components of the invention include, but are not limited to conductors, resistors, current collectors, capacitors, piezoelectronic devices, inductors and transformers. The present invention also provides energy storage devices and electrode layers for such energy storage devices having passive, electrically-conductive particles coated with one or more thin film materials. |
| FILED | Wednesday, March 02, 2022 |
| APPL NO | 17/685346 |
| CURRENT CPC | Processes for Applying Fluent Materials to Surfaces, in General B05D 1/00 (20130101) Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/16 (20220101) B22F 1/17 (20220101) Original (OR) Class B22F 1/054 (20220101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/34 (20130101) C23C 16/40 (20130101) C23C 16/0236 (20130101) C23C 16/403 (20130101) C23C 16/442 (20130101) C23C 16/4417 (20130101) C23C 16/45525 (20130101) C23C 16/45555 (20130101) C23C 18/1216 (20130101) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 4/008 (20130101) H01G 4/30 (20130101) H01G 4/0085 (20130101) H01G 4/1227 (20130101) H01G 11/24 (20130101) H01G 11/30 (20130101) H01G 11/50 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/62 (20130101) H01M 4/366 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220402194 | Rodriguez et al. |
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| FUNDED BY |
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| APPLICANT(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jennifer Nicole Rodriguez (Fremont, California); Eric B. Duoss (Dublin, California); James Lewicki (Oakland, California); Christopher Spadaccini (Oakland, California); Thomas S. Wilson (Oakland, California); Cheng Zhu (Livermore, California) |
| ABSTRACT | An additive manufacturing apparatus includes an additive manufacturing print head and a nozzle that receives a bio-based shape memory polymer material and a bio-based material. The nozzle extrudes the bio-based shape memory polymer material and the bio-based material onto a substrate to form a bio-based shape memory polymer part or product. |
| FILED | Tuesday, August 16, 2022 |
| APPL NO | 17/820144 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/106 (20170801) Original (OR) Class B29C 64/165 (20170801) B29C 64/209 (20170801) B29C 64/321 (20170801) B29C 64/393 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 70/10 (20200101) B33Y 80/00 (20141201) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/046 (20170501) C08K 7/04 (20130101) Compositions of Macromolecular Compounds C08L 63/00 (20130101) C08L 91/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220402384 | Asa et al. |
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| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Erdem Asa (Oak Ridge, Tennessee); Veda Prakash Galigekere (Oak Ridge, Tennessee); Omer C. Onar (Oak Ridge, Tennessee); Burak Ozpineci (Oak Ridge, Tennessee); Jason L. Pries (Oak Ridge, Tennessee); Gui-Jia Su (Oak Ridge, Tennessee) |
| ABSTRACT | A method for wirelessly or conductively (non-wireless) providing AC or DC power in AC or DC load applications and bidirectional applications. |
| FILED | Monday, August 22, 2022 |
| APPL NO | 17/892401 |
| CURRENT CPC | Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 53/60 (20190201) B60L 53/122 (20190201) Original (OR) Class B60L 2210/20 (20130101) B60L 2210/30 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 7/0047 (20130101) H02J 50/12 (20160201) H02J 50/80 (20160201) H02J 2310/48 (20200101) Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 5/293 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220402754 | Black et al. |
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| FUNDED BY |
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| APPLICANT(S) | Brookhaven Science Associates LLC (Upton, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles T. Black (New York, New York); Atikur Rahman (Ridge, New York); Matthew Eisaman (Port Jefferson, New York); Ahsan Ashraf (Port Jefferson, New York) |
| ABSTRACT | Methods for etching nanostructures in a substrate include depositing a patterned block copolymer on the substrate, the patterned block copolymer including first and second polymer block domains, applying a precursor to the patterned block copolymer to generate an infiltrated block copolymer, the precursor infiltrating into the first polymer block domain and generating a material in the first polymer block domain, applying a removal agent to the infiltrated block copolymer to generate a patterned material, the removal agent removing the first and second polymer block domains from the substrate, and etching the substrate, the patterned material on the substrate masking the substrate to pattern the etching. The etching may be performed under conditions to produce nanostructures in the substrate. |
| FILED | Wednesday, July 06, 2022 |
| APPL NO | 17/858855 |
| CURRENT CPC | Processes or Apparatus Specially Adapted for the Manufacture or Treatment of Microstructural Devices or Systems B81C 1/00031 (20130101) Original (OR) Class B81C 1/00111 (20130101) B81C 2201/0132 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) B82Y 40/00 (20130101) Optical Elements, Systems, or Apparatus G02B 1/118 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/0002 (20130101) G03F 7/405 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0271 (20130101) H01L 21/0273 (20130101) H01L 21/0337 (20130101) H01L 21/3065 (20130101) H01L 21/3086 (20130101) H01L 31/02363 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403235 | Myllenbeck et al. |
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| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas Myllenbeck (Livermore, California); Patrick L. Feng (Livermore, California); Joseph Carlson (Castro Valley, California) |
| ABSTRACT | A plastic scintillator includes a polymeric matrix comprising a primary fluorophore capable of forming an amorphous glass in its pure form. The primary fluorophore is also capable of generating luminescence in the presence of ionizing radiation and includes: a central species including silicon; a luminescent organic group bonded to the central species or to an optional organic linker group, the luminescent organic group including fluorene or an analog thereof; and the optional organic linker group, if present, is bonded to the central species and the luminescent organic group. |
| FILED | Friday, August 05, 2022 |
| APPL NO | 17/881859 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) Original (OR) Class C09K 11/025 (20130101) C09K 2211/1011 (20130101) C09K 2211/1014 (20130101) C09K 2211/1018 (20130101) Measurement of Nuclear or X-radiation G01T 1/2033 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403257 | Singh et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| INVENTOR(S) | Vijay Singh (Savoy, Illinois); Ramkrishna Singh (Urbana, Illinois) |
| ABSTRACT | The disclosure provides various methods for separating and recovering free fatty acids crude oil containing free fatty acids using certain ion-exchange resins to reduce the amount of free fatty acids in the crude oil to 3% or less such that the resultant oil is useable in downstream chemical processes. After separation and removal of the free fatty acids form the crude oil, the ion-exchange resin is reusable in further free fatty acid separation reactions. |
| FILED | Tuesday, May 31, 2022 |
| APPL NO | 17/828955 |
| CURRENT CPC | Cracking Hydrocarbon Oils; Production of Liquid Hydrocarbon Mixtures, e.g by Destructive Hydrogenation, Oligomerisation, Polymerisation; Recovery of Hydrocarbon Oils From Oil-shale, Oil-sand, or Gases; Refining Mixtures Mainly Consisting of Hydrocarbons; Reforming of Naphtha; Mineral Waxes C10G 25/02 (20130101) Original (OR) Class C10G 25/006 (20130101) C10G 25/12 (20130101) C10G 2300/201 (20130101) C10G 2300/1007 (20130101) C10G 2300/4081 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403403 | MALIK et al. |
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| FUNDED BY |
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| APPLICANT(S) | YIELD10 BIOSCIENCE, INC. (Woburn, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Meghna MALIK (Saskatoon, None); Jihong TANG (West Roxbury, Massachusetts); Yuanyuan JI (, None); Kristi D. SNELL (Belmont, Massachusetts) |
| ABSTRACT | A genetically modified plant that exhibits an increase in seed yield relative to a progenitor plant is disclosed. The genetically modified plant includes (a) a first homeolog of the SUGAR-DEPENDENT1 (SDP1) gene being homozygous for a wild-type allele; and (b) a second homeolog of the SDP1 gene being homozygous for a mutant allele. The wild-type allele encodes an active SDP1 triacylglycerol lipase and is identical to an allele of the first homeolog from the progenitor plant. The mutant allele does not encode an active SDP1 triacylglycerol lipase and includes one or more additions, deletions, or substitutions of one or more nucleotides relative to an allele of the second homeolog from the progenitor plant. The genetically modified plant expresses about 20% to 80% of SDP1 triacylglycerol lipase activity in seeds relative to the progenitor. The increase in seed yield is at least 10%. |
| FILED | Wednesday, July 22, 2020 |
| APPL NO | 17/597707 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8213 (20130101) C12N 15/8247 (20130101) C12N 15/8261 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403425 | LIAO et al. |
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| FUNDED BY |
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| APPLICANT(S) | CARGILL, INCORPORATED (Wayzata, Minnesota) |
| ASSIGNEE(S) | CARGILL, INCORPORATED (Wayzata, Minnesota) |
| INVENTOR(S) | Hans H. LIAO (Plymouth, Minnesota); Catherine Bradshaw POOR (Plymouth, Minnesota); Travis Robert WOLTER (Plymouth, Minnesota); Michael Tai Man LOUIE (Plymouth, Minnesota); Erin Kathleen MARASCO (Plymouth, Minnesota); Ana NEGRETE-RAYMOND (Plymouth, Minnesota) |
| ABSTRACT | Genes encoding mutant 3-ketoacyl-CoA synthases are introduced into host cells. Certain of the mutants enhance the production of shorter-chain fatty acids and derivatives by the cell than do the wild-type (unmutated) enzymes. In other cases, the chain length is not significantly affected, but productivity is enhanced. In specific cases, both a shift toward lower chain length and higher productivity is seen. Cells producing the mutant 3-ketoacyl-CoA synthases are especially suitable for producing C6-C10 fatty acids and derivatives. |
| FILED | Monday, May 02, 2022 |
| APPL NO | 17/661613 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 9/1029 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/6409 (20130101) C12P 7/6436 (20130101) Original (OR) Class Enzymes C12Y 203/01199 (20150701) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403523 | Lepro Chavez et al. |
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| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xavier N. Lepro Chavez (Livermore, California); Chantel M. Aracne-Ruddle (Livermore, California); Salmaan H. Baxamusa (Livermore, California); Michael Stadermann (Livermore, California) |
| ABSTRACT | Provided herein is a nanoscale material assembly made up of a plurality of nanoscale structures with a crosslinked polymer thermally deposited on the structures. Also disclosed are methods for preparing the nanoscale material assembly with a deposited crosslinked polymer. Further disclosed are various conditions and materials that when used in the preparation of the nanoscale material assemblies further enhance their mechanical properties. In some embodiments, the nanoscale material assemblies can be either nanoscale yarn assemblies or nanoscale sheet assemblies. |
| FILED | Friday, July 01, 2022 |
| APPL NO | 17/856545 |
| CURRENT CPC | Processes for Applying Fluent Materials to Surfaces, in General B05D 1/60 (20130101) B05D 1/62 (20130101) B05D 3/007 (20130101) B05D 3/067 (20130101) B05D 2203/35 (20130101) B05D 2256/00 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 70/00 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/56 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403811 | BOREN et al. |
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| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Blake Craig BOREN (Corvallis, Oregon); Jochem WEBER (Golden, Colorado) |
| ABSTRACT | Disclosed herein are flexible wave energy converters that actuate electrical generators with dynamic strain (e.g., flexing, stretching, twisting, distension) to convert wave energy to electrical energy. The flexible wave energy converter utilizes flexible electric generators embedded throughout the wave-energy converter's flexible body. |
| FILED | Tuesday, June 28, 2022 |
| APPL NO | 17/851418 |
| CURRENT CPC | Machines or Engines for Liquids F03B 13/188 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403838 | Siebert |
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| FUNDED BY |
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| APPLICANT(S) | United States Department of Energy (Washington, District of Columbia) |
| ASSIGNEE(S) | United States Department of Energy (Washington, District of Columbia) |
| INVENTOR(S) | Brett W. Siebert (Niskayuna, New York) |
| ABSTRACT | Disclosed is a flow device including an inlet, an outlet, and a plurality of fluid flow paths hydraulically connected in parallel to the inlet and the outlet, wherein the plurality of fluid flow paths forms a first ring of fluid flow paths circumferentially arranged at a first radial distance from a centerline of the fluid flow device a second ring of fluid flow patch circumferentially arranged at a second radial distance from the centerline of the fluid flow device, each of the plurality of fluid flow paths has a first hydraulic resistance in a forward flow direction and a second hydraulic resistance in a reverse flow direction, and the second hydraulic resistance is greater than the first hydraulic resistance. |
| FILED | Monday, November 08, 2021 |
| APPL NO | 17/520804 |
| CURRENT CPC | Positive-displacement Machines for Liquids; Pumps F04B 53/1077 (20130101) Original (OR) Class Fluid Dynamics, i.e Methods or Means for Influencing the Flow of Gases or Liquids F15D 1/04 (20130101) Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 51/00 (20130101) Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 2210/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220404212 | PEGNA et al. |
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| FUNDED BY |
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| APPLICANT(S) | FREE FORM FIBERS, LLC (Saratoga Springs, New York) |
| ASSIGNEE(S) | FREE FORM FIBERS, LLC (Saratoga Springs, New York) |
| INVENTOR(S) | Joseph PEGNA (Saratoga Springs, New York); Thomas Philip BUDKA (Niskayuna, New York) |
| ABSTRACT | Methods of fabricating fiber structures with embedded sensors are provided. The method includes obtaining a scaffold fiber and forming, by 1½-D printing using laser induced chemical vapor deposition, circuitry on the scaffold fiber to provide a fiber structure with embedded sensor. The forming includes printing a solid state oscillator about the scaffold fiber, and printing a sensing device about the scaffold fiber electrically coupled to the solid state oscillator to effect, at least in part, oscillations of the solid state oscillator. The forming further includes printing an antenna about the scaffold fiber electrically connected to the solid state oscillator to facilitate in operation wireless transmitting of a signal from the fiber structure with embedded sensor. |
| FILED | Monday, April 11, 2022 |
| APPL NO | 17/658665 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 80/00 (20141201) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/48 (20130101) Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 3/14 (20130101) Original (OR) Class G01K 7/02 (20130101) G01K 17/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220404235 | CADER et al. |
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| FUNDED BY |
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| APPLICANT(S) | HEWLETT PACKARD ENTERPRISE DEVELOPMENT LP (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | TAHIR CADER (Liberty Lake, Washington); SERGEY SEREBRYAKOV (Milpitas, California); TORSTEN WILDE (Berlin, Germany); JEFF HANSON (Houston, Texas) |
| ABSTRACT | Systems and methods are provided for improving statistical and machine learning drift detection models that monitor computing health of a data center environment. For example, the system can receive streams of sensor data from a plurality of sensors in a data center; clean the streams of sensor data; generate, using a machine learning (ML) model, an anomaly score and a dynamic threshold value based on the cleaned streams of sensor data; determine, using the ML model and based on the anomaly score and the dynamic threshold value, a correctness indicator for a first sensor in the plurality of sensors; and using the correctness indicator, correct the first sensor. |
| FILED | Thursday, June 17, 2021 |
| APPL NO | 17/351085 |
| CURRENT CPC | Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 99/005 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220404276 | O'Dowd et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Niall O'Dowd (San Diego, California); Michael Todd (San Diego, California) |
| ABSTRACT | In one aspect, there is provided a system including at least one processor; and at least one memory including program code which when executed by the at least one processor causes operations including capturing an image of at least a portion of a surface of an object; generating, from the captured image, pixel intensity data; in response to generating the pixel intensity data, determining, based on a height error model, height error data, wherein the height error data indicates an uncertainty of at least one height measurement of the object; and determining, based on the height error data, whether the object satisfies a threshold criteria for acceptance of the object. Related system, methods, and articles of manufacture are also disclosed. |
| FILED | Thursday, November 12, 2020 |
| APPL NO | 17/775530 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 11/0616 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/45 (20130101) Original (OR) Class G01N 21/8806 (20130101) G01N 2021/456 (20130101) G01N 2021/8829 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220404287 | Launiere et al. |
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| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Cari A. Launiere (Bolingbrook, Illinois); Nathaniel C. Hoyt (Clarendon Hills, Illinois) |
| ABSTRACT | A flow cell system includes a vessel and a fluid located in the vessel. A fluid surface of the fluid can be vented to a first gas pressure. The fluid surface can have a first cross-sectional area. The flow cell system includes a conduit in fluid communication with the vessel and positioned downstream of the vessel. The conduit can have a region that includes one or more orifices and has a second cross-sectional area. The second cross-sectional area can be less than the first cross-sectional area. The one or more orifices can be vented to a second gas pressure. The second gas pressure can be equal to or greater than the first gas pressure. Methods for analyzing a process fluid can include characterizing the fluid in the conduit. |
| FILED | Thursday, June 17, 2021 |
| APPL NO | 17/351010 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/38 (20130101) G01N 21/31 (20130101) G01N 21/85 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220406408 | Verzi et al. |
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| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen Joseph Verzi (Albuquerque, New Mexico); Craig Michael Vineyard (Cedar Crest, New Mexico); James Bradley Aimone (Keller, Texas) |
| ABSTRACT | Anomaly detection for streaming data is provided. A spiking neural network receives inputs of streaming data, wherein each input is contained within a number of neighborhoods and converts the inputs into phase-coded spikes. A median value of each input is calculated for each size neighborhood containing the input, and an absolute difference of each input from its median value is calculated for each size neighborhood. From the absolute differences, a median absolute difference (MAD) value of each input is calculated for each size neighborhood. It is determined whether the MAD value for any size neighborhood exceeds a respective threshold. If the MAD value exceeds its threshold, an anomaly indication is output for the input. If none of the MAD values for the neighborhoods exceeds its threshold, a normal indication is output for the input. |
| FILED | Thursday, August 18, 2022 |
| APPL NO | 17/890843 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 3/049 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 30/00 (20190201) Original (OR) Class G16B 40/20 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220406480 | MCCLURE |
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| FUNDED BY |
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| APPLICANT(S) | Triiad National Security, LLC (Los Alamos, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Patrick Ray MCCLURE (Los Alamos, New Mexico) |
| ABSTRACT | A mobile heat pipe cooled fast nuclear reactor may be configured for transportation to remote locations and may be able to provide 0.5 to 2 megawatts of power. The mobile heat pipe cooled fast reactor may contain a plurality of heat pipes that are proximate to a plurality of fuel pins inside the reactor. The plurality of heat pipes may extend out of the reactor. The reactor may be configured to be placed in a standard shipping container, and may further be configured to be contained within a cask and attached to a skid for easier transportation. |
| FILED | Thursday, July 14, 2022 |
| APPL NO | 17/864642 |
| CURRENT CPC | Nuclear Reactors G21C 1/02 (20130101) G21C 15/257 (20130101) Original (OR) Class Nuclear Power Plant G21D 5/02 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 30/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220406506 | Hartman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| INVENTOR(S) | Seth Hartman (Kansas City, Missouri); Erik Timpson (Kansas City, Missouri) |
| ABSTRACT | An electromagnetic propulsion system is provided. The system comprises first and second pluralities of stator coils wound about first and second axes, a plurality of support structures, first and second couplers that surround portions of the first and second pluralities of stator coils, and first and second pluralities of sets of rotor coils wound about axes that are parallel to the first and second axes. The stator coils are configured to receive electric current through an outside controller selecting appropriately coupled stator sections or through a sliding electrical contact system or bearing system to induce at least a first magnetic field. The plurality of support structures supports the first and second plurality of stator coils. The first and second couplers include notches and are oriented so that their notches pass over the plurality of support structures when the couplers move along the stator coils. The couplers may have an adjustable segment to close the notch. The sets of rotor coils are equidistantly attached to the couplers and are configured to receive electric current to induce magnetic fields that interact with the magnetic fields of the stator coils so that magnetic forces are applied to the plurality of rotor coils, thereby propelling the couplers along the stator coils. |
| FILED | Thursday, August 18, 2022 |
| APPL NO | 17/890630 |
| CURRENT CPC | Weapons for Projecting Missiles Without Use of Explosive or Combustible Propellant Charge; Weapons Not Otherwise Provided for F41B 6/003 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 7/17 (20130101) H01F 7/064 (20130101) Original (OR) Class Dynamo-electric Machines H02K 1/2786 (20130101) H02K 5/167 (20130101) H02K 7/09 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220406508 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgetown University (Washington, District of Columbia); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gong Chen (EL Cerrito, California); Kai Liu (Falls Church, Virginia); Andreas Schmid (Berkeley, California) |
| ABSTRACT | Embodiments may provide the realization of strong Dzyaloshinskii-Moriya Interaction (DMI) and perpendicular magnetic anisotropy (PMA) induced by chemisorbed species on a ferromagnetic layer. For example, in an embodiment, an apparatus for generating a Dzyaloshinskii-Moriya interaction may comprise a ferromagnet comprising a single layer or multi-layers of materials made of metal, oxide or other types of magnetic films, and a substance chemisorbed on a surface of the ferromagnet to induce the Dzyaloshinskii-Moriya interaction or the perpendicular magnetic anisotropy at the interface between chemisorbed species and ferromagnet. These induced effects may be used to manipulate spin textures such as switching of domain wall chirality and writing/deleting of magnetic skyrmions, which are relevant for spintronics, magneto-ionics as well as gas sensing. |
| FILED | Thursday, August 13, 2020 |
| APPL NO | 17/636963 |
| CURRENT CPC | Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 10/3236 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220406561 | BLOOM et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Integrated Dynamic Electron Solutions, Inc. (Pleasanton, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ruth Shewmon BLOOM (Oakland, California); Bryan Walter REED (San Leandro, California); Daniel Joseph MASIEL (Alamo, California); Sang Tae PARK (Danville, California) |
| ABSTRACT | A device may include an electron source, a detector, and a deflector. The electron source may be directed toward a sample area. The detector may receive an electron signal or an electron-induced signal. A deflector may be positioned between the electron source and the sample. The deflector may modulate an intensity of the electron source directed to the sample area according to an electron dose waveform having a continuously variable temporal profile. |
| FILED | Thursday, May 26, 2022 |
| APPL NO | 17/825261 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 37/28 (20130101) H01J 37/147 (20130101) H01J 37/243 (20130101) Original (OR) Class H01J 37/292 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220406962 | Xu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaohui Xu (Lafayette, Indiana); Zachariah Olson Martin (West Lafayette, Indiana); Demid Sychev (West Lafayette, Indiana); Alexei S. Lagutchev (West Lafayette, Indiana); Yong Chen (West Lafayette, Indiana); Vladimir Michael Shalaev (West Lafayette, Indiana); Alexandra Boltasseva (West Lafayette, Indiana) |
| ABSTRACT | Methods of fabricating single photon emitters (SPEs) including nanoindentation of hexagonal boron nitride (hBN) host materials and annealing thereof, devices formed from such methods, and chips with a single photon emitter. A substrate with a layer of hBN is provided. Nanoindentation is performed on the layer of hBN to produce an array of sub-micron indentations in the layer of hBN. The layer of hBN is annealed to activate SPEs near the indentations. Devices include a substrate with an SPE produced in accordance with the methods. Chips include a substrate, an hBN layer, and an SPE including an indentation on the hBN layer, in which the substrate is not damaged at the indentation. |
| FILED | Tuesday, June 21, 2022 |
| APPL NO | 17/845093 |
| CURRENT CPC | Scanning-probe Techniques or Apparatus; Applications of Scanning-probe Techniques, e.g Scanning Probe Microscopy [SPM] G01Q 60/366 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 33/025 (20130101) Original (OR) Class H01L 33/32 (20130101) H01L 33/0075 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220406984 | Ahmed et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GTI ENERGY (DES PLAINES, Illinois) |
| ASSIGNEE(S) | GTI ENERGY (DES PLAINES, Illinois) |
| INVENTOR(S) | Abdelallah Ahmed (Thousand Oaks, California); John C. VEGA, III (Camarillo, California); Jeffrey A. MAYS (Woodland Hills, California); David E. MORRISON, II (Hesperia, California) |
| ABSTRACT | An integrated combustor-thermoelectric generator and method for producing electrical power and/or for operating a pneumatic or electric device. The apparatus includes a burner tube, a tubular heat exchanger extending along and around the burner tube, a plurality of thermoelectric generators disposed along sides of the heat exchanger, and a heat sink on an opposite side of the thermoelectric generators from the burner and heat exchanger. The thermoelectric generators can be paired with an electric valve or a DC air compressor for operating a pneumatic device by directing heated gases from the combustor through the heat exchanger to thermoelectric couples and/or modules for powering the air compressor. The thermoelectric generator and DC compressor can be installed to a natural gas source at a well pad for operating a pneumatic device at the well pad. |
| FILED | Tuesday, June 21, 2022 |
| APPL NO | 17/845338 |
| CURRENT CPC | Burners F23D 14/10 (20130101) Casings, Linings, Walls or Doors Specially Adapted for Combustion Chambers, e.g Firebridges; Devices for Deflecting Air, Flames or Combustion Products in Combustion Chambers; Safety Arrangements Specially Adapted for Combustion Apparatus; Details of Combustion Chambers, Not Otherwise Provided for F23M 20/00 (20150115) F23M 2900/13003 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 35/30 (20130101) Original (OR) Class H01L 35/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220407051 | Evans et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | TESLA, INC. (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tyler Evans (Broomfield, Colorado); Daniela Molina Piper (Broomfield, Colorado) |
| ABSTRACT | Large-scale anodes containing high weight percentages of silicon suitable for use in lithium-ion energy storage devices and batteries, and methods of manufacturing the same, are described. The anode material described herein can include a film cast on a current collector substrate, with the film including a plurality of active material particles and a conductive polymer membrane coated over the active material particles. In some embodiments, the conductive polymer membrane comprises polyacrylonitrile (PAN). The method of manufacturing the anode material can include preparation of a slurry including the active material particles and the conductive polymer material, casting the slurry on a current collector substrate, and subjecting the composite material to drying and heat treatments. |
| FILED | Wednesday, June 22, 2022 |
| APPL NO | 17/808285 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/133 (20130101) H01M 4/134 (20130101) H01M 4/364 (20130101) Original (OR) Class H01M 4/386 (20130101) H01M 4/0404 (20130101) H01M 4/0471 (20130101) H01M 4/587 (20130101) H01M 4/624 (20130101) H01M 50/411 (20210101) H01M 2004/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220407078 | VISWANATHAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Venkatasubramanian VISWANATHAN (Pittsburgh, Pennsylvania); Vikram PANDE (Pittsburgh, Pennsylvania); Yet-Ming CHIANG (Pittsburgh, Pennsylvania) |
| ABSTRACT | The invention comprises an anode-free lithium metal cell having an anode-side current collector composed of lithium, a lithium alloy or lithium-containing compound or a transition metal having a lithium or lithium alloy or lithium-containing compound surface coating, to provide a specific energy of the cell of 350 Wh/kg or greater. |
| FILED | Wednesday, August 19, 2020 |
| APPL NO | 17/635987 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/0407 (20130101) H01M 4/662 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220407111 | Bayley et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Apple Inc. (Cupertino, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul M. Bayley (Santa Clara, California); Libo Hu (Mountain View, California); Hongli Dai (Los Altos, California); Zhengcheng Zhang (Naperville, Illinois); Qian Liu (Darien, Illinois); Khalil Amine (Oak Brook, Illinois); Mingfu He (Palos Park, Illinois) |
| ABSTRACT | This disclosure relates generally to battery cells, and more particularly, electrolyte additives for use in lithium ion battery cells. |
| FILED | Thursday, June 02, 2022 |
| APPL NO | 17/830951 |
| CURRENT CPC | Heterocyclic Compounds C07D 207/14 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0525 (20130101) H01M 10/0567 (20130101) Original (OR) Class H01M 10/0568 (20130101) H01M 10/0569 (20130101) H01M 2300/0042 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220407112 | Dai et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Apple Inc. (Cupertino, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hongli Dai (Los Altos, California); Libo Hu (Mountain View, California); Paul M. Bayley (Santa Clara, California); Zhengcheng Zhang (Naperville, Illinois); Khalil Amine (Oak Brook, Illinois); Qian Liu (Darien, Illinois); Mingfu He (Palos Park, Illinois) |
| ABSTRACT | This disclosure relates generally to battery cells, and more particularly, electrolyte additives for use in lithium ion battery cells. |
| FILED | Thursday, June 02, 2022 |
| APPL NO | 17/830964 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0525 (20130101) H01M 10/0567 (20130101) Original (OR) Class H01M 10/0568 (20130101) H01M 10/0569 (20130101) H01M 10/0585 (20130101) H01M 2300/0042 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220407283 | McIntyre et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States Department of Energy (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dustin McIntyre (Washington, Pennsylvania); Daniel Hartzler (Westover, West Virginia) |
| ABSTRACT | One or more embodiments relates to a method of growing ultrasmooth and high quantum efficiency CsTe photocathodes. The method includes exposing a substrate of Cs using an alkali source such as an effusion cell; and controlling co-evaporating growth and co-deposition forming a CsTe growth. The method further includes monitoring a stoichiometry of the CsTe growth. |
| FILED | Friday, August 26, 2022 |
| APPL NO | 17/896141 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/31 (20130101) G01N 2201/08 (20130101) G01N 2201/0633 (20130101) G01N 2201/0634 (20130101) G01N 2201/0636 (20130101) G01N 2201/06113 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/11 (20130101) H01S 3/106 (20130101) Original (OR) Class H01S 3/094038 (20130101) H01S 3/094053 (20130101) H01S 3/094096 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220407449 | Lepley et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TECTONICUS CONSTRUCTS, LLC (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin Lepley (Tucson, Arizona); George Cairo (Mesa, Arizona) |
| ABSTRACT | A cross canal support structure for photovoltaic cells is disclosed. The structure includes a major frame having disconnectable and hinged connections to anchors at its corners, on either side of the canal. The major frame carries a plurality of minor frames, which are inclinable at an angle with respect to the major frame with the use of fixed or adjustable mounting plates. The combination of the major frame's tilt and the minor frame tilt enables fabrication of support structures that hold panels at latitude inclination for various portions of a canal. |
| FILED | Wednesday, June 16, 2021 |
| APPL NO | 17/349795 |
| CURRENT CPC | Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 20/30 (20141201) Original (OR) Class H02S 30/10 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220407453 | Bermel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter Andrew Bermel (West Lafayette, Indiana); David Jonathan Kortge (West Lafayette, Indiana); Ze Wang (West Lafayette, Indiana); Zhiguang Zhou (San Jose, California); Jie Zhu (West Lafayette, Indiana) |
| ABSTRACT | A radiatively cooled solar array, including a downwardly-facing solar cell and a mirror positioned below the solar cell and oriented to direct sunlight onto the solar cell. The assembly also includes a heat sink in thermal communication with the solar cell and disposed opposite the mirror. The heat sink is in radiative communication through Earth's atmosphere with outer space. |
| FILED | Wednesday, January 26, 2022 |
| APPL NO | 17/585470 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/052 (20130101) Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 40/22 (20141201) H02S 40/42 (20141201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20220401349 | Jeffries et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Xylome Corporation (Madison, Wisconsin) |
| ASSIGNEE(S) | Xylome Corporation (Madison, Wisconsin) |
| INVENTOR(S) | Thomas W. Jeffries (Madison, Wisconsin); Thomas J. Kelleher (Thousand Oaks, California); David Z. Mokry (Madison, Wisconsin); Richard Taylor (Madison, Wisconsin); Austin Gluth (Stoughton, Wisconsin); Merrill S. Goldenberg (Thousand Oaks, California) |
| ABSTRACT | The invention provides lipid bodies isolated from yeast, compositions comprising the lipid bodies, products made from the lipid bodies, methods of making the lipid bodies, and methods of using the lipid bodies. The lipid bodies of the invention have an exceptionally large size and high internal neutral lipid content, providing a number of advantages for a variety of practical applications. |
| FILED | Friday, November 13, 2020 |
| APPL NO | 17/776485 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 8/553 (20130101) A61K 8/9728 (20170801) Original (OR) Class A61K 2800/56 (20130101) Specific Use of Cosmetics or Similar Toilet Preparations A61Q 19/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401367 | Scott et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Evan Alexander Scott (Evanston, Illinois); Michael Patrick Vincent (Evanston, Illinois); Sharan Kumar Reddy Bobbala (Evanston, Illinois) |
| ABSTRACT | Provided herein are rehydratable powdered formulations of nanocarriers that can be used to encompass hydrophobic or hydrophilic cargo. The formulations can be used for medicinal, agricultural, and research applications. Methods of making the formulations are also provided. |
| FILED | Thursday, June 16, 2022 |
| APPL NO | 17/807372 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1623 (20130101) A61K 9/1641 (20130101) A61K 9/1647 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401736 | Herron et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Jeffrey Andrew Herron (Seattle, Washington); Benjamin Isaac Ferleger (Seattle, Washington); Howard Jay Chizeck (Seattle, Washington); Andrew L. Ko (Seattle, Washington) |
| ABSTRACT | Embodiments of the disclosure are drawn to implantable stimulator with machine learning based classifier. An implantable system includes sensors which provide sensor information to an implantable unit. The implantable unit uses a classifier on the sensor information to select a stimulation procedure which is applied via a stimulation electrode. The classifier may be generated by a trained machine learning model. The classifier may be trained on an external unit which is not implanted in the subject. The classifier may be trained based on sensor information from the implanted sensors as well as symptom information. |
| FILED | Wednesday, March 23, 2022 |
| APPL NO | 17/656156 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0534 (20130101) A61N 1/36139 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401908 | Gonzalez |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lina Gonzalez (Worcester, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lina Gonzalez (Worcester, Massachusetts) |
| ABSTRACT | A material with a scaffold comprising a series of at least partially spaced fibers and gas vesicles locates between fibers. The gas vesicles comprise external anchoring modules that are effective to anchor the gas vesicles to the fibers. |
| FILED | Monday, August 02, 2021 |
| APPL NO | 17/391352 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/0091 (20130101) Original (OR) Class Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 101/08 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/04 (20130101) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/02 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220402024 | Niauzorau et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Stanislau Niauzorau (Gilbert, Arizona); Aliaksandr Sharstniou (Gilbert, Arizona); Amm G. Hasib (Tempe, Arizona); Bruno Azeredo (Tempe, Arizona); Natalya Kublik (Tempe, Arizona); Kenan Song (Gilbert, Arizona); Nikhilesh Chawla (West Lafayette, Indiana); Sridhar Niverty (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stanislau Niauzorau (Gilbert, Arizona); Aliaksandr Sharstniou (Gilbert, Arizona); Amm G. Hasib (Tempe, Arizona); Bruno Azeredo (Tempe, Arizona); Natalya Kublik (Tempe, Arizona); Kenan Song (Gilbert, Arizona); Nikhilesh Chawla (West Lafayette, Indiana); Sridhar Niverty (West Lafayette, Indiana) |
| ABSTRACT | A method of making a metal-polymer composite includes dealloying metallic powder to yield porous metal particles, monitoring a temperature of the mixture, controlling the rate of combining, a maximum temperature of the mixture, or both, and combining the porous metal particles with a polymer to yield a composite. Dealloying includes combining the metallic powder with an etchant to yield a mixture. A metal-polymer composite includes porous metal particles having an average particle size of about 0.2 μm to about 500 μm and a thermoplastic or thermoset polymer. The polymer composite comprises at least 10 vol % of the porous metal particles. A powder mixture includes porous metal particles having an average particle size of about 0.2 μm to about 500 μm and a metal powder. The powder mixture includes about 1 wt % to about 99 wt % of the porous metal particles. |
| FILED | Wednesday, June 15, 2022 |
| APPL NO | 17/841371 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/05 (20220101) B22F 1/10 (20220101) Original (OR) Class B22F 1/145 (20220101) B22F 10/18 (20210101) B22F 2301/10 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 40/10 (20200101) B33Y 70/10 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220402065 | Ramirez et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Antonio Ramirez (Columbus, Ohio); Rafael Arthur Reghine Giorjao (Columbus, Ohio); Bryan Lara (Columbus, Ohio) |
| ABSTRACT | Disclosed herein are compositions, methods, and systems for resistance spot welding or brazing an aluminum member to a steel member using a chromium layer disposed between the aluminum member and the steel member. |
| FILED | Wednesday, June 22, 2022 |
| APPL NO | 17/846159 |
| CURRENT CPC | Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 11/20 (20130101) Original (OR) Class B23K 11/115 (20130101) B23K 11/185 (20130101) B23K 35/3086 (20130101) B23K 2103/05 (20180801) Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 15/012 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220402944 | Schoenfisch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark H. Schoenfisch (Chapel Hill, North Carolina); Robert J. Soto (Durham, North Carolina) |
| ABSTRACT | Nitric oxide-releasing mesoporous silica nanoparticles (MSNs) were prepared using an aminosilane-template surfactant ion exchange reaction. Initially, bare silica particles were synthesized under basic conditions in the presence of cetyltrimethylammonium bromide (CTAB). These particles were functionalized with nitric oxide (NO) donor precursors via the addition of aminosilane directly to the particle sol, and a commensurate ion exchange reaction between the cationic aminosilanes and CTAB. N-diazeniumdiolate NO donors were formed at the secondary amines to yield NO-releasing silica MSNs. Tuning of the ion exchange-based MSN modification approach allowed for the preparation of monodisperse particles ranging from 30 to 1100 nm. Regardless of size, the MSNs stored appreciable levels of NO (0.4-1.5 μmol/mg) with tunable NO-release durations (1-33 h) dependent on the aminosilane modification. The range of MSN sizes and NO release demonstrate the versatility of this strategy. |
| FILED | Monday, August 22, 2022 |
| APPL NO | 17/821371 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 33/00 (20130101) A61K 47/24 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/103 (20130101) B01J 20/3085 (20130101) B01J 20/28007 (20130101) B01J 20/28016 (20130101) B01J 20/28083 (20130101) Non-metallic Elements; Compounds Thereof; C01B 21/24 (20130101) C01B 33/18 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2004/61 (20130101) C01P 2004/62 (20130101) C01P 2004/64 (20130101) C01P 2006/17 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/188 (20130101) Original (OR) Class C07F 7/1804 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403091 | Nash et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Landon D. Nash (Sunnyvale, California); Kendal P. Ezell (Tomball, Texas) |
| ABSTRACT | An embodiment includes a system comprising: an iodine containing thermoset open-cell shape memory polymer (SMP) foam that is x-ray visible; wherein (a) the SMP foam is configured to expand from a compressed secondary state to an expanded primary state in response to thermal stimulus, (b) the SMP foam is a poly(urethane-urea-amide). Other embodiments are described herein. |
| FILED | Friday, August 05, 2022 |
| APPL NO | 17/881695 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/73 (20130101) C08G 18/3206 (20130101) C08G 18/3215 (20130101) C08G 18/3275 (20130101) Original (OR) Class C08G 18/3821 (20130101) C08G 18/3897 (20130101) C08G 18/5018 (20130101) C08G 2280/00 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/0066 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403290 | Lu |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University Of Cincinnati (Cincinnati, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mingming Lu (Mason, Ohio) |
| ABSTRACT | A method of forming a yellow grease is provided. The method includes delivering a FOG lipid extraction agent into a processing tank. The method further includes preheating a waste grease to a temperature of between 35° C. and 95° C. The method further includes mixing the preheated waste grease with the FOG lipid extraction agent in the processing tank to form the yellow grease. |
| FILED | Monday, June 13, 2022 |
| APPL NO | 17/806613 |
| CURRENT CPC | Producing, e.g by Pressing Raw Materials or by Extraction From Waste Materials, Refining or Preserving Fats, Fatty Substances, e.g Lanolin, Fatty Oils or Waxes; Essential Oils; Perfumes C11B 13/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403338 | Lipke et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Auburn University (Auburn, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elizabeth A. Lipke (Auburn, Alabama); Petra Kerscher (Auburn, Alabama); Alexander J. Hodge (Auburn, Alabama) |
| ABSTRACT | The present invention relates to the production of cell cultures and tissues from undifferentiated pluripotent stem cells using three-dimensional biomimetic materials. The resultant cell cultures or tissues can be used in any of a number of protocols including testing chemicals, compounds, and drugs. Further, the methods and compositions of the present invention further provide viable cell sources and novel cell delivery platforms that allow for replacement of diseased tissue and engraftment of new cardiomyocytes from a readily available in vitro source. The present invention includes novel methods required for the successful production of cell cultures and tissues, systems and components used for the same, and methods of using the resultant cell and tissue compositions. |
| FILED | Friday, June 24, 2022 |
| APPL NO | 17/808873 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0657 (20130101) Original (OR) Class C12N 5/0696 (20130101) C12N 2500/46 (20130101) C12N 2500/50 (20130101) C12N 2501/999 (20130101) C12N 2506/45 (20130101) C12N 2513/00 (20130101) C12N 2533/52 (20130101) C12N 2533/54 (20130101) C12N 2537/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403367 | WANG |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (NEW YORK, New York) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (NEW YORK, New York) |
| INVENTOR(S) | Harris He WANG (New York, New York) |
| ABSTRACT | The present invention relates to utilizing engineered horizontal gene transfer elements and high-throughput selection strategies to tag and retrieve genetically modified native commensal strains from the mammalian gut. In certain aspects, the present invention relates to methods wherein isolated bacteria from the mammalian gut microbiome that were amenable to genetic manipulation were redeployed back into the mammalian subject as host-optimized engineerable probiotics. |
| FILED | Monday, January 13, 2020 |
| APPL NO | 17/422373 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/74 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 15/102 (20130101) Original (OR) Class C12N 15/1086 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403378 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yang Liu (Baltimore, Maryland); Roger Zou (Baltimore, Maryland); Bin Wu (Baltimore, Maryland); Taekjip Ha (Baltimore, Maryland) |
| ABSTRACT | A very fast and efficient CRISPR/Cas9 system is provided. Compositions include light-sensitive caged nucleotides at the PAM distal region of guide RNAs (gRNAcaged) to create artificial mismatches as a “roadblock”. Upon light stimulation, the caging group (“roadblock”) is removed and the gRNA fully hybridizes with the target DNA. Thus, the pre-bound inactive Cas9/gRNAcaged is rapidly converted to active Cas9. |
| FILED | Sunday, October 25, 2020 |
| APPL NO | 17/770512 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/111 (20130101) Original (OR) Class C12N 15/902 (20130101) C12N 2310/20 (20170501) C12N 2310/3511 (20130101) C12N 2320/11 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403424 | Rullán Lind et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Puerto Rico (San Juan, Puerto Rico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carlos Ralph Rullán Lind (San Juan, Puerto Rico); Abel Juan Baerga Ortiz (San Juan, Puerto Rico) |
| ABSTRACT | The disclosure provides fused dimer constructs that enhance fatty acid production and methods for making the dimer constructs. The fused dimer comprises Fab A and/or FabZ enzymes. |
| FILED | Thursday, March 05, 2020 |
| APPL NO | 17/435709 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/88 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/6409 (20130101) Original (OR) Class Enzymes C12Y 402/01059 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403453 | Minev et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Dionis Minev (Cambridge, Massachusetts); Christopher Wintersinger (Cambridge, Massachusetts); William M. Shih (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein, in some embodiments, are methods, compositions and kits for controlling nucleation and assembly of molecular nanostructures, microstructures and macrostructures. |
| FILED | Friday, January 14, 2022 |
| APPL NO | 17/576550 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 1/00 (20130101) C07H 21/00 (20130101) C07H 21/04 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6811 (20130101) C12Q 1/6837 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403555 | Jao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rowan University (Glassboro, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dave Jao (Glassboro, New Jersey); Vince Beachley (Medford Lakes, New Jersey) |
| ABSTRACT | In one aspect, the present disclosure provides processes and systems for producing multiple fibers simultaneously, or nearly simultaneously. |
| FILED | Monday, June 13, 2022 |
| APPL NO | 17/838948 |
| CURRENT CPC | Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 4/02 (20130101) Original (OR) Class D01D 4/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403557 | Xu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Weiheng Xu (Chandler, Arizona); Kenan Song (Gilbert, Arizona); Yuxiang Zhu (Gilbert, Arizona); Sayli Jambhulkar (Gilbert, Arizona); Dharneedar Ravichandran (Tempe, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Weiheng Xu (Chandler, Arizona); Kenan Song (Gilbert, Arizona); Yuxiang Zhu (Gilbert, Arizona); Sayli Jambhulkar (Gilbert, Arizona); Dharneedar Ravichandran (Tempe, Arizona) |
| ABSTRACT | Fabricating a multilayered polymer nanocomposite fiber includes injecting a first polymer solution and a second polymer solution to a head of spinneret to yield a two-layered fiber precursor in the spinneret, passing the two-layered fiber precursor through one or more multipliers in the spinneret to yield a multilayered fiber precursor having 2n+1 layers, passing the multilayered fiber precursor through a gap between an exit of the spinneret and into a coagulation bath, and coagulating the multilayered fiber precursor in the coagulation bath to yield a multilayered polymer nanocomposite fiber. The multilayered polymer nanocomposite fiber includes alternating layers of a first polymer formed from the first polymer solution and a second polymer formed from the second polymer solution. The second polymer solution includes carbon nanostructures. |
| FILED | Tuesday, June 14, 2022 |
| APPL NO | 17/839975 |
| CURRENT CPC | Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/04 (20130101) D01D 5/28 (20130101) Original (OR) Class Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 1/10 (20130101) D01F 8/08 (20130101) Making Textile Fabrics, e.g From Fibres or Filamentary Material; Fabrics Made by Such Processes or Apparatus, e.g Felts, Non-woven Fabrics; Cotton-wool; Wadding D04H 3/002 (20130101) D04H 3/005 (20130101) Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles D10B 2101/122 (20130101) D10B 2321/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403766 | MASOUDI et al. |
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| FUNDED BY |
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| APPLICANT(S) | EMISSOL LLC (Mill Creek, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mansour MASOUDI (Mill Creek, Washington); Jacob Roy HENSEL (Mill Creek, Washington); Edward Benjamin TEGELER, IV (Mill Creek, Washington); Nikolai Alex POLIAKOV (Mill Creek, Washington) |
| ABSTRACT | A segmented, heated urea mixer and an exhaust system to control NOx emission from combustion engines comprising a plurality of elements, at least one element independently heatable by an external power source to a temperature above a temperature of another element. A method of using the exhaust gas mixer and an exhaust gas mixer system further comprising a controller is also disclosed. |
| FILED | Tuesday, September 29, 2020 |
| APPL NO | 17/764124 |
| CURRENT CPC | Gas-flow Silencers or Exhaust Apparatus for Machines or Engines in General; Gas-flow Silencers or Exhaust Apparatus for Internal Combustion Engines F01N 3/2013 (20130101) F01N 3/2066 (20130101) F01N 3/2892 (20130101) Original (OR) Class F01N 2240/16 (20130101) F01N 2240/20 (20130101) F01N 2240/25 (20130101) F01N 2570/14 (20130101) F01N 2610/02 (20130101) F01N 2610/102 (20130101) F01N 2610/105 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220404259 | Yanik et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ahmet Ali Yanik (Santa Cruz, California); Xiangchao Zhu (Santa Cruz, California); Yixiang Li (Santa Cruz, California) |
| ABSTRACT | An optofluidic device includes: a housing having an inlet port coupled to an inlet side and an outlet port coupled to an outlet side; and a microlens disposed within the housing between the inlet side and the outlet side. A fluid having a plurality of particles flows from the inlet side through the microlens to the outlet side. The optofluidic device further includes a light source configured to emit a light beam in a direction opposite flow direction of the fluid, the light beam defining an optical axis that is perpendicular to the microlens. |
| FILED | Tuesday, June 14, 2022 |
| APPL NO | 17/839826 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1056 (20130101) Original (OR) Class G01N 2015/1006 (20130101) G01N 2015/1081 (20130101) G01N 2015/1087 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220404309 | Arias et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ana Claudia Arias (Oakland, California); Xiaodong Wu (Oakland, California) |
| ABSTRACT | Potentiometric sensors based on potentiometric mechanosensation and/or thermosensation mechanisms operate by regulating the potential difference between electrodes at two different electrode/electrolyte interfaces. A potentiometric sensor may include at least a first electrode, a second electrode, and a microstructured ionic hydrogel composite electrolyte in contact with the first electrode and the second electrode. Methods of making a potentiometric sensor device may include forming a first electrode on a substrate, forming a second electrode on the substrate, and applying a microstructured ionic hydrogel composite electrolyte structure in contact with both the first and second electrodes. |
| FILED | Monday, May 16, 2022 |
| APPL NO | 17/745383 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/1477 (20130101) Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 7/26 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/413 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220404340 | Mead et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin Mead (Cambridge, Massachusetts); Conner Samuel Kummerlowe (Cambridge, Massachusetts); Alexander K. Shalek (Cambridge, Massachusetts) |
| ABSTRACT | Described in certain example embodiments herein are systems, methods, and uses thereof for high-throughput in vitro evaluating multiple test compounds in parallel for biological or pharmacological functions. In certain embodiments, the system allows the selection of a subset of test compounds from a group of test compounds to form an optimized pool, and methods are provided to use such optimized pool of test compounds to identify and validate therapeutic agents for treating diseases and driving guided differentiation of stem cells into desired types of cells. The systems described herein can provide, for example, a cost-effective and high-quality high-throughput approach for drug screening. |
| FILED | Friday, October 23, 2020 |
| APPL NO | 17/771309 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/502 (20130101) G01N 33/5082 (20130101) Original (OR) Class Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) G16B 40/20 (20190201) Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 20/50 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220404344 | Aspinwall et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Craig A. Aspinwall (Tucson, Arizona); Minhui Han (Tucson, Arizona); Colleen Janczak (Tucson, Arizona) |
| ABSTRACT | The present invention provides silica shell encapsulated polyaromatic-core microparticles and methods for producing and using the same. In particular, the silica shell encapsulated polyaromatic-core microparticles of the invention are hydrophilic microparticle scintillators comprising (i) polyaromatic-core microparticle (1), wherein said polyaromatic-core microparticle (1) is doped with a scintillator material (2); and (ii) a silica-shell portion (3) encapsulating said polyaromatic-core microparticle (1), wherein said silica-shell portion (3) comprises an outer surface (4). The polyaromatic-core portion is formed from an aromatic vinyl compound selected from the group consisting of styrene, vinyl toluene, and a mixture thereof. |
| FILED | Sunday, November 15, 2020 |
| APPL NO | 17/777011 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/533 (20130101) G01N 33/547 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220404357 | HUGHES et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Montana Molecular LLC (Bozeman, Montana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas E. HUGHES (Bozeman, Montana); Paul H. TEWSON (Bozeman, Montana); Anne Marie QUINN (Bozeman, Montana) |
| ABSTRACT | Described herein are novel fluorescent sensors for cyclic adenosine monophosphate (cAMP) that are based on single fluorescent proteins. These sensors use less visible spectrum than FRET-based sensors, produce robust changes in fluorescence, and can be combined with one another, or with other sensors, in a multiplex assay on standard fluorescent plate readers or live cell imaging systems. |
| FILED | Wednesday, May 25, 2022 |
| APPL NO | 17/824643 |
| CURRENT CPC | Peptides C07K 14/00 (20130101) C07K 2319/60 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/542 (20130101) G01N 33/566 (20130101) Original (OR) Class G01N 33/582 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220405663 | Kezunovic et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | The Texas A and M University System (College Station, Texas) |
| INVENTOR(S) | Mladen Kezunovic (College Station, Texas); Tatjana Dokic (College Station, Texas); Zoran Obradovic (College Station, Texas) |
| ABSTRACT | A system for generating a dynamic tree trimming schedule, comprising a network vegetation model system operating on a first processor and configured to receive a network vegetation model and weather forecast data and to generate a real-time tree trimming schedule as a function of the network vegetation model and weather forecast data and a remote user interface operating on a second processor and configured to receive the real-time tree trimming schedule and to generate one or more user interface controls as a function of the real-time tree trimming schedule. |
| FILED | Thursday, June 16, 2022 |
| APPL NO | 17/842244 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/06311 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220405923 | Pandolfino et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Erik Pandolfino (Wilmette, Illinois); Neelesh Ashok Patankar (Buffalo Grove, Illinois); Sourv Halder (Evanston, Illinois); Shashank Acharya (Evanston, Illinois); Peter James Kahrilas (Chicago, Illinois) |
| ABSTRACT | Flow through tubular organs (e.g., the esophagus) is analyzed based on fluid mechanics analysis of medical images. Using computational fluid dynamics, a reduced-order model is constructed and implemented to predict flow rate and fluid pressure developed inside flexible tubular organs inside the body. As one non-limiting example, the constructed model can be applied to analyze esophageal transport using fluoroscopy image sequences to predict flow rate, pressure, esophagus wall stiffness, and active relaxation. |
| FILED | Monday, November 23, 2020 |
| APPL NO | 17/779124 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 3/40 (20130101) G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 7/20 (20130101) G06T 2207/10064 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30092 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 15/00 (20180101) G16H 30/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220406508 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgetown University (Washington, District of Columbia); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gong Chen (EL Cerrito, California); Kai Liu (Falls Church, Virginia); Andreas Schmid (Berkeley, California) |
| ABSTRACT | Embodiments may provide the realization of strong Dzyaloshinskii-Moriya Interaction (DMI) and perpendicular magnetic anisotropy (PMA) induced by chemisorbed species on a ferromagnetic layer. For example, in an embodiment, an apparatus for generating a Dzyaloshinskii-Moriya interaction may comprise a ferromagnet comprising a single layer or multi-layers of materials made of metal, oxide or other types of magnetic films, and a substance chemisorbed on a surface of the ferromagnet to induce the Dzyaloshinskii-Moriya interaction or the perpendicular magnetic anisotropy at the interface between chemisorbed species and ferromagnet. These induced effects may be used to manipulate spin textures such as switching of domain wall chirality and writing/deleting of magnetic skyrmions, which are relevant for spintronics, magneto-ionics as well as gas sensing. |
| FILED | Thursday, August 13, 2020 |
| APPL NO | 17/636963 |
| CURRENT CPC | Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 10/3236 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220406589 | JARROLD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin F. JARROLD (Bloomington, Indiana); Aaron R. TODD (Bloomington, Indiana) |
| ABSTRACT | A system for separating ions may include an ion source configured to generate ions from a sample, at least one ion separation instrument configured to separate the generated ions as a function of at least one molecular characteristic, and an orbitrap in which a rotating and oscillating ion induces charges on inner and outer electrode halves of the orbitrap, and wherein charge detection circuitry is configured to detect the charges induced on each of the inner electrode halves and on each of the outer electrode halves, and to combine the detected charges for each oscillation to produce a measured ion charge signal. |
| FILED | Monday, August 22, 2022 |
| APPL NO | 17/892625 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 49/425 (20130101) Original (OR) Class H01J 49/4255 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220406962 | Xu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaohui Xu (Lafayette, Indiana); Zachariah Olson Martin (West Lafayette, Indiana); Demid Sychev (West Lafayette, Indiana); Alexei S. Lagutchev (West Lafayette, Indiana); Yong Chen (West Lafayette, Indiana); Vladimir Michael Shalaev (West Lafayette, Indiana); Alexandra Boltasseva (West Lafayette, Indiana) |
| ABSTRACT | Methods of fabricating single photon emitters (SPEs) including nanoindentation of hexagonal boron nitride (hBN) host materials and annealing thereof, devices formed from such methods, and chips with a single photon emitter. A substrate with a layer of hBN is provided. Nanoindentation is performed on the layer of hBN to produce an array of sub-micron indentations in the layer of hBN. The layer of hBN is annealed to activate SPEs near the indentations. Devices include a substrate with an SPE produced in accordance with the methods. Chips include a substrate, an hBN layer, and an SPE including an indentation on the hBN layer, in which the substrate is not damaged at the indentation. |
| FILED | Tuesday, June 21, 2022 |
| APPL NO | 17/845093 |
| CURRENT CPC | Scanning-probe Techniques or Apparatus; Applications of Scanning-probe Techniques, e.g Scanning Probe Microscopy [SPM] G01Q 60/366 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 33/025 (20130101) Original (OR) Class H01L 33/32 (20130101) H01L 33/0075 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220407453 | Bermel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter Andrew Bermel (West Lafayette, Indiana); David Jonathan Kortge (West Lafayette, Indiana); Ze Wang (West Lafayette, Indiana); Zhiguang Zhou (San Jose, California); Jie Zhu (West Lafayette, Indiana) |
| ABSTRACT | A radiatively cooled solar array, including a downwardly-facing solar cell and a mirror positioned below the solar cell and oriented to direct sunlight onto the solar cell. The assembly also includes a heat sink in thermal communication with the solar cell and disposed opposite the mirror. The heat sink is in radiative communication through Earth's atmosphere with outer space. |
| FILED | Wednesday, January 26, 2022 |
| APPL NO | 17/585470 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/052 (20130101) Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 40/22 (20141201) H02S 40/42 (20141201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220407763 | Giannakis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Georgios B. Giannakis (Minnetonka, Minnesota); Xiaoli Ma (Auburn, Alabama) |
| ABSTRACT | Techniques are described for carrier frequency offset (CFO) and channel estimation of orthogonal frequency division multiplexing (OFDM) transmissions over multiple-input multiple-output (MIMO) frequency-selective fading channels. A wireless transmitter forms blocks of symbols by inserting training symbols within two or more blocks of information-bearing symbols. The transmitter applies a hopping code to each of the blocks of symbols to insert a null subcarrier at a different position within each of the blocks of symbols, and a modulator outputs a wireless signal in accordance with the blocks of symbols. A receiver receives the wireless signal and estimates the CFO, and outputs a stream of estimated symbols based on the estimated CFO. |
| FILED | Wednesday, April 06, 2022 |
| APPL NO | 17/714926 |
| CURRENT CPC | Transmission H04B 7/046 (20130101) H04B 7/063 (20130101) H04B 7/066 (20130101) H04B 7/0413 (20130101) Multiplex Communication H04J 11/0063 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 5/0016 (20130101) H04L 25/0202 (20130101) H04L 25/0206 (20130101) H04L 25/0228 (20130101) H04L 25/0242 (20130101) H04L 27/2607 (20130101) H04L 27/2613 (20130101) H04L 27/2626 (20130101) Original (OR) Class H04L 27/2657 (20130101) H04L 27/2671 (20130101) H04L 27/2672 (20130101) H04L 27/2675 (20130101) H04L 27/2692 (20130101) H04L 27/2695 (20130101) H04L 27/26134 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20220401023 | Madabhushi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio); The United States Govemment as Represented by The Department of Veteran Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anant Madabhushi (Shaker Heights, Ohio); Mohammadhadi Khorrami (Cleveland Heights, Ohio); Prantesh Jain (Cleveland, Ohio); Afshin Dowlati (Solon, Ohio) |
| ABSTRACT | Various embodiments of the present disclosure are directed towards a method for predicting a response to treatment of small cell lung cancer (SCLC). The method includes generating a radiomic risk score (RRS) for the patient based on a plurality of radiomic features, wherein the RRS is prognostic of overall survival (OS) of the patient. The RRS is provided to a machine learning classifier that is trained to predict a response of the patient to a SCLC chemotherapy treatment based, at least in part, on the RRS. The machine learning classifier provides a classification of the patient into either a responder group (RG) or a non-responder group (NRG), where the NRG indicates the patient will not respond to the SCLC chemotherapy treatment and the RG indicates that the patient will respond to the SCLC chemotherapy treatment. |
| FILED | Friday, November 19, 2021 |
| APPL NO | 17/530711 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4848 (20130101) Original (OR) Class A61B 5/7267 (20130101) A61B 5/7275 (20130101) A61B 2576/02 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/10081 (20130101) G06T 2207/10116 (20130101) G06T 2207/30061 (20130101) G06T 2207/30096 (20130101) Image or Video Recognition or Understanding G06V 10/44 (20220101) G06V 10/764 (20220101) G06V 10/774 (20220101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/10 (20180101) G16H 30/40 (20180101) G16H 50/20 (20180101) G16H 50/30 (20180101) G16H 50/70 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401621 | Cullen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania); The United States of America as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Kacy Cullen (Media, Pennsylvania); Justin C. Burrell (Philadelphia, Pennsylvania); Joseph Cole Maggiore (Pittsburgh, Pennsylvania) |
| ABSTRACT | In various aspects and embodiments, the present invention provides methods for maintaining motor neuron health in the spinal cord and pro-regenerative capacity of a proximal nerve segment subsequent to a nerve injury in a subject in need thereof, the methods comprising transplanting a stretch-grown tissue engineered nerve graft (TENG) into a proximal site contacting the proximal nerve segment. |
| FILED | Wednesday, November 18, 2020 |
| APPL NO | 17/776829 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/383 (20130101) A61L 27/3633 (20130101) A61L 27/3675 (20130101) Original (OR) Class A61L 27/3834 (20130101) A61L 27/3878 (20130101) A61L 2300/62 (20130101) A61L 2430/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403172 | HELGASON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VitroLabs Inc (South San Francisco, California); King's College London (London, United Kingdom) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ingvar HELGASON (South San Francisco, California); Dusko ILIC (London, United Kingdom) |
| ABSTRACT | Disclosed herein are synthetic leathers, artificial epidermal layers, artificial dermal layers, layered structures, products produced therefrom and methods of producing the same. |
| FILED | Monday, May 23, 2022 |
| APPL NO | 17/751440 |
| CURRENT CPC | Compositions of Macromolecular Compounds C08L 89/06 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0625 (20130101) C12N 5/0629 (20130101) C12N 5/0698 (20130101) C12N 11/02 (20130101) C12N 2501/155 (20130101) C12N 2501/385 (20130101) C12N 2502/13 (20130101) C12N 2502/091 (20130101) C12N 2502/094 (20130101) C12N 2506/45 (20130101) C12N 2533/30 (20130101) C12N 2533/54 (20130101) Chemical Treatment of Hides, Skins or Leather, e.g Tanning, Impregnating, Finishing; Apparatus Therefor; Compositions for Tanning C14C 3/02 (20130101) C14C 13/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403469 | Niculescu, III |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Indiana University Research and Technology Corporation (Indianapolis, Indiana) |
| ASSIGNEE(S) | United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | Alexander Bogdan Niculescu, III (Indianapolis, Indiana) |
| ABSTRACT | Disclosed are novel compounds for treating and preventing schizophrenia, and more generally psychosis, by bioinformatics drug repurposing using novel genes expression biomarkers involved in psychotic symptoms (delusions, hallucinations); methods for assessing severity, determining future risk, matching with a drug treatment, and measuring response to treatment, for psychosis in a subject; and method of using repurposed drugs and natural compounds to prevent and to treat psychosis. Methods are disclosed using a universal approach, in everybody, as well as personalized approaches by gender. The discovery describes compounds for use in everybody (universal), as well as personalized by gender (males, females). Methods for identifying which subjects should be receiving which treatment, using genes expression biomarkers for patient stratification and measuring response to treatment. The disclosure also relates to algorithms. The algorithms combine biomarkers as well as clinical measures for psychosis, to identify subjects who are at risk of psychosis, and to track responses to treatments. |
| FILED | Thursday, June 17, 2021 |
| APPL NO | 17/351132 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/158 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 25/10 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220404364 | Madabhushi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio); The United States Government as Represented by The Department of Veteran Affairs (Washington, District of Columbia); The Cleveland Clinic Foundation (Cleveland, Ohio); University Hospitals of Cleveland (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anant Madabhushi (Shaker Heights, Ohio); Nathaniel Braman (Bethel Park, Pennsylvania); Siddharth Kunte (Toledo, Ohio); Alberto Montero (Cleveland, Ohio) |
| ABSTRACT | The present disclosure relates to a method of determining a prognostic outlook for patients having metastatic breast cancer. The method includes receiving imaging data from an image of a patient that is receiving or that is to receive cycline dependent kinase 4 and 6 (CDK 4/6) inhibitor therapy for hormone receptor-positive (HR+) metastatic breast cancer. Radiomic heterogeneity features are extracted from imaging data associated with a metastasis within the imaging. A prognostic marker is determined from the radiomic heterogeneity features. The prognostic marker is indicative of a response of the patient to CDK 4/6 inhibitor therapy for HR+ metastatic breast cancer. |
| FILED | Tuesday, November 23, 2021 |
| APPL NO | 17/533458 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57415 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/30096 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220405917 | Madabhushi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio); The United States Government as Represented by The Department of Veteran Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anant Madabhushi (Shaker Heights, Ohio); Cristian Barrera (Shaker Heights, Ohio); Mohammadhadi Khorrami (Cleveland Heights, Ohio); Prantesh Jain (Cleveland, Ohio); Afshin Dowlati (Solon, Ohio) |
| ABSTRACT | The present disclosure relates to a non-transitory computer-readable medium storing computer-executable instructions that, when executed, cause a processor to perform operations, including generating an imaging data set having both scan data and digitized biopsy data from a patient with small cell lung cancer (SCLC). Scan derived features are extracted from the scan data and biopsy derived features are extracted from the digitized biopsy data. A radiomic-pathomic risk score (RPRS) is calculated from one or more of the scan derived features and one or more of the biopsy derived features. The RPRS is indicative of a prognosis of the patient. |
| FILED | Monday, February 14, 2022 |
| APPL NO | 17/670817 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/7264 (20130101) A61B 5/7275 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 7/40 (20130101) G06T 2207/10081 (20130101) G06T 2207/20081 (20130101) G06T 2207/30024 (20130101) G06T 2207/30061 (20130101) G06T 2207/30096 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/40 (20180101) G16H 30/40 (20180101) G16H 50/20 (20180101) G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220405918 | Madabhushi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio); The United States Government as Represented by The Department of Veteran Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anant Madabhushi (Shaker Heights, Ohio); Sepideh Azarianpour Esfahani (Cleveland Heights, Ohio); Haider Mahdi (Wexford, Pennsylvania) |
| ABSTRACT | Various embodiments of the present disclosure are directed towards a method for generating a risk group classification for an African American (AA) patient. The method includes extracting a first plurality of architectural features from a digitized H&E slide image of the AA patient. A risk score for the AA patient is generated based on the first plurality of architectural features, where the risk score is prognostic of overall survival (OS) of the AA patient. The risk group classification is generated for the AA patient, where generating the risk group classification includes classifying the AA patient into either a high risk group or a low risk group based on the risk score, where the high risk group indicates the AA patient will die before a threshold date and the low risk group indicates the AA patient will die after or on the threshold date. |
| FILED | Tuesday, February 15, 2022 |
| APPL NO | 17/671882 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 2207/30024 (20130101) G06T 2207/30096 (20130101) Image or Video Recognition or Understanding G06V 10/764 (20220101) G06V 10/774 (20220101) G06V 20/698 (20220101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20220400726 | KOZUBAL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Fynder Group, Inc. (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark A. KOZUBAL (Bozeman, Montana); Richard E. MACUR (Manhattan, Montana); Yuval C. AVNIEL (Missoula, Montana); Maximilian DeVane HAMILTON (Bozeman, Montana) |
| ABSTRACT | Methods of production of edible filamentous fungal biomat formulations are provided as standalone protein sources and/or protein ingredients in foodstuffs as well as a one-time use or repeated use self-contained biofilm-biomat reactor comprising a container with at least one compartment and placed within the compartment(s), a feedstock, a fungal inoculum, a gas-permeable membrane, and optionally a liquid nutrient medium. |
| FILED | Friday, August 19, 2022 |
| APPL NO | 17/891857 |
| CURRENT CPC | Dairy Products, e.g Milk, Butter, Cheese; Milk or Cheese Substitutes; Making Thereof A23C 9/1203 (20130101) Cocoa; Cocoa Products, e.g Chocolate; Substitutes for Cocoa or Cocoa Products; Confectionery; Chewing Gum; Ice-cream; Preparation Thereof A23G 9/36 (20130101) Protein Compositions for Foodstuffs; Working-up Proteins for Foodstuffs; Phosphatide Compositions for Foodstuffs A23J 3/20 (20130101) A23J 3/227 (20130101) Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 29/065 (20160801) A23L 31/00 (20160801) Original (OR) Class A23L 33/195 (20160801) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) A23V 2250/208 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/00 (20130101) C12M 23/24 (20130101) C12M 23/34 (20130101) C12M 23/40 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/14 (20130101) C12N 1/145 (20210501) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/77 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220400946 | Mujat et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Physical Sciences, Inc. (Andover, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mircea Mujat (Acton, Massachusetts); Nicusor Iftimia (Windham, New Hampshire) |
| ABSTRACT | A method for determining a calibration factor in Doppler flowmetry velocity measurements in the living eye includes imaging the eye with Doppler flowmetry and processing data to obtain blood velocity, volume, and flow maps using Doppler flowmetry formulas that provide velocity as a mean frequency expressed in Hz, and volume and flow in arbitrary units. A selected blood vessel is probed with Doppler OCT to measure the absolute velocity of blood at that location expressed in mm/s to determine a calibration factor used to convert the velocity measured with Doppler flowmetry expressed in Hz to velocity expressed in mm/s. |
| FILED | Friday, April 15, 2022 |
| APPL NO | 17/721728 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/102 (20130101) Original (OR) Class A61B 3/1025 (20130101) A61B 3/1233 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403774 | Chandler et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Technologies Corporation (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jesse M. Chandler (South Windsor, Connecticut); Gabriel L. Suciu (Glastonbury, Connecticut) |
| ABSTRACT | A gas turbine engine for an aircraft includes a core engine assembly including a compressor section communicating air to a combustor section where the air is mixed with fuel and ignited to generate a high-energy gas flow that is expanded through a turbine section. The turbine section is coupled to drive the compressor section. A free turbine is configured to be driven by gas flow from the core engine. A propulsor section aft of the core engine and is driven by the free turbine. An exhaust duct routes exhaust gases from the core engine to the free turbine. The free turbine is disposed aft of the propulsor section and the exhaust duct includes an outlet aft of the propulsor section communicating gas flow to drive the free turbine. An aircraft is also disclosed. |
| FILED | Friday, April 08, 2022 |
| APPL NO | 17/716290 |
| CURRENT CPC | Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 27/10 (20130101) B64D 33/02 (20130101) B64D 33/04 (20130101) Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 25/30 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 3/10 (20130101) Original (OR) Class F02C 7/36 (20130101) Jet-propulsion Plants F02K 3/12 (20130101) F02K 3/062 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2250/314 (20130101) F05D 2260/40311 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220407200 | Chattopadhyay et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Goutam Chattopadhyay (Pasadena, California); Jacob W. Kooi (Pasadena, California); Choonsup Lee (La Palma, California); Sofia Rahiminejad (Pasadena, California); Subash Khanal (Pasadena, California) |
| ABSTRACT | A waveguide based variable attenuator device including one or more attenuators each including a porous dielectric material; and a metal coating on the top of the dielectric material; and an actuator coupled to the attenuator. The actuator is configured to position, with nanometer resolution, the one or more attenuators in a waveguide configured and dimensioned to guide an electromagnetic wave having a frequency in a range of 100 gigahertz (GHz) to 1 terahertz (THz). The actuator controls at least one of a position or a volume of the one attenuator inserted in the waveguide to achieve a variable or pre-determined attenuation of the electromagnetic wave transmitted through waveguide. |
| FILED | Wednesday, June 22, 2022 |
| APPL NO | 17/846971 |
| CURRENT CPC | Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 1/222 (20130101) Original (OR) Class H01P 11/00 (20130101) Transmission H04B 1/04 (20130101) H04B 1/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20220400726 | KOZUBAL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Fynder Group, Inc. (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark A. KOZUBAL (Bozeman, Montana); Richard E. MACUR (Manhattan, Montana); Yuval C. AVNIEL (Missoula, Montana); Maximilian DeVane HAMILTON (Bozeman, Montana) |
| ABSTRACT | Methods of production of edible filamentous fungal biomat formulations are provided as standalone protein sources and/or protein ingredients in foodstuffs as well as a one-time use or repeated use self-contained biofilm-biomat reactor comprising a container with at least one compartment and placed within the compartment(s), a feedstock, a fungal inoculum, a gas-permeable membrane, and optionally a liquid nutrient medium. |
| FILED | Friday, August 19, 2022 |
| APPL NO | 17/891857 |
| CURRENT CPC | Dairy Products, e.g Milk, Butter, Cheese; Milk or Cheese Substitutes; Making Thereof A23C 9/1203 (20130101) Cocoa; Cocoa Products, e.g Chocolate; Substitutes for Cocoa or Cocoa Products; Confectionery; Chewing Gum; Ice-cream; Preparation Thereof A23G 9/36 (20130101) Protein Compositions for Foodstuffs; Working-up Proteins for Foodstuffs; Phosphatide Compositions for Foodstuffs A23J 3/20 (20130101) A23J 3/227 (20130101) Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 29/065 (20160801) A23L 31/00 (20160801) Original (OR) Class A23L 33/195 (20160801) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) A23V 2250/208 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/00 (20130101) C12M 23/24 (20130101) C12M 23/34 (20130101) C12M 23/40 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/14 (20130101) C12N 1/145 (20210501) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/77 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220401349 | Jeffries et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Xylome Corporation (Madison, Wisconsin) |
| ASSIGNEE(S) | Xylome Corporation (Madison, Wisconsin) |
| INVENTOR(S) | Thomas W. Jeffries (Madison, Wisconsin); Thomas J. Kelleher (Thousand Oaks, California); David Z. Mokry (Madison, Wisconsin); Richard Taylor (Madison, Wisconsin); Austin Gluth (Stoughton, Wisconsin); Merrill S. Goldenberg (Thousand Oaks, California) |
| ABSTRACT | The invention provides lipid bodies isolated from yeast, compositions comprising the lipid bodies, products made from the lipid bodies, methods of making the lipid bodies, and methods of using the lipid bodies. The lipid bodies of the invention have an exceptionally large size and high internal neutral lipid content, providing a number of advantages for a variety of practical applications. |
| FILED | Friday, November 13, 2020 |
| APPL NO | 17/776485 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 8/553 (20130101) A61K 8/9728 (20170801) Original (OR) Class A61K 2800/56 (20130101) Specific Use of Cosmetics or Similar Toilet Preparations A61Q 19/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220403349 | KORMAN |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | INVIZYNE TECHNOLOGIES, INC. (Monrovia, California) |
| ASSIGNEE(S) | INVIZYNE TECHNOLOGIES, INC. (Monrovia, California) |
| INVENTOR(S) | Tyler P. KORMAN (Sierra Madre, California) |
| ABSTRACT | The present disclosure relates to recombinant prenyltransferase enzymes with increased thermostability and activity and the use of these enzymes in compositions and methods for biosynthesis involving prenylation reactions, including compositions and methods for the preparation of cannabinoids. |
| FILED | Wednesday, May 25, 2022 |
| APPL NO | 17/824118 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1085 (20130101) Original (OR) Class C12N 15/52 (20130101) C12N 15/8243 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/42 (20130101) Enzymes C12Y 203/01206 (20150701) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220404357 | HUGHES et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Montana Molecular LLC (Bozeman, Montana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas E. HUGHES (Bozeman, Montana); Paul H. TEWSON (Bozeman, Montana); Anne Marie QUINN (Bozeman, Montana) |
| ABSTRACT | Described herein are novel fluorescent sensors for cyclic adenosine monophosphate (cAMP) that are based on single fluorescent proteins. These sensors use less visible spectrum than FRET-based sensors, produce robust changes in fluorescence, and can be combined with one another, or with other sensors, in a multiplex assay on standard fluorescent plate readers or live cell imaging systems. |
| FILED | Wednesday, May 25, 2022 |
| APPL NO | 17/824643 |
| CURRENT CPC | Peptides C07K 14/00 (20130101) C07K 2319/60 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/542 (20130101) G01N 33/566 (20130101) Original (OR) Class G01N 33/582 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20220406508 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgetown University (Washington, District of Columbia); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gong Chen (EL Cerrito, California); Kai Liu (Falls Church, Virginia); Andreas Schmid (Berkeley, California) |
| ABSTRACT | Embodiments may provide the realization of strong Dzyaloshinskii-Moriya Interaction (DMI) and perpendicular magnetic anisotropy (PMA) induced by chemisorbed species on a ferromagnetic layer. For example, in an embodiment, an apparatus for generating a Dzyaloshinskii-Moriya interaction may comprise a ferromagnet comprising a single layer or multi-layers of materials made of metal, oxide or other types of magnetic films, and a substance chemisorbed on a surface of the ferromagnet to induce the Dzyaloshinskii-Moriya interaction or the perpendicular magnetic anisotropy at the interface between chemisorbed species and ferromagnet. These induced effects may be used to manipulate spin textures such as switching of domain wall chirality and writing/deleting of magnetic skyrmions, which are relevant for spintronics, magneto-ionics as well as gas sensing. |
| FILED | Thursday, August 13, 2020 |
| APPL NO | 17/636963 |
| CURRENT CPC | Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 10/3236 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
20220407001 — Novel Nanocomposite Phase-Change Memory Materials and Design and Selection of the Same
| US 20220407001 | Takeuchi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland); University of Washington (Seattle, Washington); Government of the United States of America as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ichiro Takeuchi (Laurel, Maryland); Heshan Yu (Greenbelt, Maryland); Changming Wu (Seattle, Washington); Mo Li (Seattle, Washington); Aaron Gilad Kusne (Rockville, Maryland) |
| ABSTRACT | Provided herein are novel materials, such as novel phase-change memory materials providing superior characteristics, and methods of discovering/selecting such novel materials via machine learning, such as Bayesian active learning. An exemplary material provided by the inventive concept is the nanocomposite phase-change memory material Ge4Sb6Te7, selected using closed-loop autonomous materials exploration and optimization (CAMEO). |
| FILED | Tuesday, February 22, 2022 |
| APPL NO | 17/651946 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/2472 (20130101) H01L 45/06 (20130101) H01L 45/16 (20130101) H01L 45/144 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Non-Profit Organization (NPO)
| US 20220403172 | HELGASON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VitroLabs Inc (South San Francisco, California); King's College London (London, United Kingdom) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ingvar HELGASON (South San Francisco, California); Dusko ILIC (London, United Kingdom) |
| ABSTRACT | Disclosed herein are synthetic leathers, artificial epidermal layers, artificial dermal layers, layered structures, products produced therefrom and methods of producing the same. |
| FILED | Monday, May 23, 2022 |
| APPL NO | 17/751440 |
| CURRENT CPC | Compositions of Macromolecular Compounds C08L 89/06 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0625 (20130101) C12N 5/0629 (20130101) C12N 5/0698 (20130101) C12N 11/02 (20130101) C12N 2501/155 (20130101) C12N 2501/385 (20130101) C12N 2502/13 (20130101) C12N 2502/091 (20130101) C12N 2502/094 (20130101) C12N 2506/45 (20130101) C12N 2533/30 (20130101) C12N 2533/54 (20130101) Chemical Treatment of Hides, Skins or Leather, e.g Tanning, Impregnating, Finishing; Apparatus Therefor; Compositions for Tanning C14C 3/02 (20130101) C14C 13/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220406508 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgetown University (Washington, District of Columbia); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gong Chen (EL Cerrito, California); Kai Liu (Falls Church, Virginia); Andreas Schmid (Berkeley, California) |
| ABSTRACT | Embodiments may provide the realization of strong Dzyaloshinskii-Moriya Interaction (DMI) and perpendicular magnetic anisotropy (PMA) induced by chemisorbed species on a ferromagnetic layer. For example, in an embodiment, an apparatus for generating a Dzyaloshinskii-Moriya interaction may comprise a ferromagnet comprising a single layer or multi-layers of materials made of metal, oxide or other types of magnetic films, and a substance chemisorbed on a surface of the ferromagnet to induce the Dzyaloshinskii-Moriya interaction or the perpendicular magnetic anisotropy at the interface between chemisorbed species and ferromagnet. These induced effects may be used to manipulate spin textures such as switching of domain wall chirality and writing/deleting of magnetic skyrmions, which are relevant for spintronics, magneto-ionics as well as gas sensing. |
| FILED | Thursday, August 13, 2020 |
| APPL NO | 17/636963 |
| CURRENT CPC | Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 10/3236 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20220402668 | JIN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as Represented by the Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ZHONGLIN T. JIN (North Wales, Pennsylvania); MADHAV P. YADAV (North Wales, Pennsylvania); PHOEBE X QI (Philadelphia, Pennsylvania) |
| ABSTRACT | A composition suitable for making edible films or coatings, the composition comprising a conjugate of bio fiber gum and whey protein isolate and at least one food grade antimicrobial. |
| FILED | Thursday, June 09, 2022 |
| APPL NO | 17/836955 |
| CURRENT CPC | Preparation or Pretreatment of the Material to be Shaped; Making Granules or Preforms; Recovery of Plastics or Other Constituents of Waste Material Containing Plastics B29B 7/74 (20130101) B29B 13/06 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 41/02 (20130101) B29C 41/003 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2089/00 (20130101) B29K 2995/0037 (20130101) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2007/008 (20130101) Containers for Storage or Transport of Articles or Materials, e.g Bags, Barrels, Bottles, Boxes, Cans, Cartons, Crates, Drums, Jars, Tanks, Hoppers, Forwarding Containers; Accessories, Closures, or Fittings Therefor; Packaging Elements; Packages B65D 65/42 (20130101) B65D 65/463 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20220407780 | Szymanski et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Boleslaw Karol Szymanski (Loudonville, New York); Amr Elsisy (Troy, New York); Aamir Mandviwalla (Troy, New York) |
| ASSIGNEE(S) | Rensselaer Polytechnic Institute (Troy, New York) |
| INVENTOR(S) | Boleslaw Karol Szymanski (Loudonville, New York); Amr Elsisy (Troy, New York); Aamir Mandviwalla (Troy, New York) |
| ABSTRACT | A method of generating a synthetic network includes receiving, by a group structure identification module, anonymized input data related to an original network. The anonymized input data includes an anonymized list of nodes, a list of edges and a list of groups. The method further includes determining, by the group structure identification module, for each pair of nodes, a probability of an edge between the pair of nodes. A resulting list of probabilities corresponds to a summary group structure. The method further includes generating, by a synthetic random network generation module, at least one synthetic random network based, at least in part, on the determined probabilities. |
| FILED | Wednesday, March 30, 2022 |
| APPL NO | 17/708212 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 41/12 (20130101) Original (OR) Class H04L 41/044 (20130101) H04L 41/145 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Justice (DOJ)
| US 20220406587 | MANICKE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas Edward MANICKE (Zionsville, Indiana); Brandon John BILLS (San Jose, California) |
| ABSTRACT | Disclosed herein are mass spectrometry sample substrates. Also disclosed herein are mass spectrometry sample strips and cartridges that include a solid phase extraction (SPE) element. The mass spectrometry sample substrates, sample strips, and cartridges can be used in paper spray mass spectrometry to detect and quantify one or more analytes present in a biological sample. Also disclosed are methods for collecting and concentrating one or more analytes from a biological sample, as well as for storing a biological sample that includes one or more analytes. Methods for analyzing the one or more analytes from the biological sample are also provided. |
| FILED | Friday, November 20, 2020 |
| APPL NO | 17/777191 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/94 (20130101) G01N 2560/00 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/0409 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of the Interior (DOI)
| US 20220401883 | Le Henaff et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anne-Claire Elisabeth Marie Le Henaff (Cambridge, Massachusetts); Wei He (Cambridge, Massachusetts); Grace Connors (Cambridge, Massachusetts); Simone Gelmini (Cambridge, Massachusetts); Amos G. Winter (Cambridge, Massachusetts); Jeffrey Dennis Costello (Cambridge, Massachusetts); Ian Marius Peters (Cambridge, Massachusetts); Kameron Conforti (Cambridge, Massachusetts) |
| ABSTRACT | A control system includes one or more levels of control of power and energy. At one level, a first controller optimally divides power between two or more processes, to maximize instantaneous production, for a given amount of currently available power. In the case of EDR desalination, electric power is optimally divided between ion exchange membranes and pumps to maximize instantaneous production of desalinated water for a given amount of available electric power. Optionally, at another level, a second controller divides time-varying power between the processes fed by the first level controller and an energy storage unit, based on a prediction of future power availability and a function. In the EDR case, power generated by a photovoltaic array is divided between the EDR desalination process and a battery, based on a prediction of future PV power availability and a function, to ensure reliable water production in the future. |
| FILED | Wednesday, October 21, 2020 |
| APPL NO | 17/770450 |
| CURRENT CPC | Separation B01D 61/54 (20130101) Original (OR) Class B01D 2313/367 (20220801) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/008 (20130101) C02F 1/4693 (20130101) C02F 2103/06 (20130101) C02F 2201/009 (20130101) C02F 2209/008 (20130101) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 13/048 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of the Treasury (TREASURY)
| US 20220402578 | Ali et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jackson State University (Jackson, Mississippi) |
| ASSIGNEE(S) | Jackson State University (Jackson, Mississippi) |
| INVENTOR(S) | Kamal S. Ali (Jackson, Mississippi); Ali Abu-El Humos (Brandon, Mississippi); James C. Addy (Terry, Mississippi); Michael P. Cameron (Brandon, Mississippi); Md Mohiuddin Hasan (Jackson, Mississippi) |
| ABSTRACT | A magnetic release assembly includes a housing defining a cavity, a permanent electromagnet positioned within the cavity, and a microcontroller electronically coupled with the permanent electromagnet. The microcontroller is configured to selectively provide power to the permanent electromagnet. A timer board is in communication with the microcontroller. A power source is electronically coupled with the microcontroller, the permanent electromagnet, and the timer board. The microcontroller is configured to provide power to the permanent electromagnet in response to an alarm from the timer board. |
| FILED | Tuesday, June 22, 2021 |
| APPL NO | 17/354755 |
| CURRENT CPC | Ships or Other Waterborne Vessels; Equipment for Shipping B63B 22/06 (20130101) Original (OR) Class Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/08 (20130101) G05B 19/0426 (20130101) G05B 2219/23193 (20130101) G05B 2219/23304 (20130101) G05B 2219/24067 (20130101) G05B 2219/25278 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 7/064 (20130101) H01F 7/0231 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Environmental Protection Agency (EPA)
| US 20220404328 | Reisfeld et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Colorado State University Research Foundation (Fort Collins, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bradley Reisfeld (Wellington, Colorado); Steven J Simske (Fort Collins, Colorado); Edward Hall (Fort Collins, Colorado) |
| ABSTRACT | Described herein are systems, methods, and devices for detecting harmful algae blooms. An example system includes autonomous watercraft; and a computing device operably connected to the autonomous watercraft over a network, the computing device including a processor and a memory having computer-executable instructions stored thereon that cause the processor to: surveil a body of water for an algae growth; receive a local condition at the body of water; predict a spread of the algae growth in the body of water based on the local condition; determine a deployment strategy for the autonomous watercraft based on the spread of the algae growth; and transmit one or more control signals to the plurality of autonomous watercraft based on the deployment strategy, where the autonomous watercraft are configured to collect and analyze a plurality of water samples to determine whether the algae growth is a harmful algae bloom. |
| FILED | Tuesday, June 21, 2022 |
| APPL NO | 17/845281 |
| CURRENT CPC | Ships or Other Waterborne Vessels; Equipment for Shipping B63B 35/00 (20130101) B63B 2035/007 (20130101) Aeroplanes; Helicopters B64C 39/024 (20130101) B64C 2201/12 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/1826 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Security Agency (NSA)
| US 20220407920 | Dinan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NVIDIA Corporation (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Dinan (Sharon, Massachusetts); Akhil Langer (Savoy, Illinois); Sreeram Potluri (Milpitas, California) |
| ABSTRACT | Apparatuses, systems, and techniques are directed to automatic coalescing of GPU-initiated network communications. In one method, a communication engine receives, from a shared memory application executing on a first graphics processing unit (GPU), a first communication request assigned to or having a second GPU as a destination to be processed. The communication engine determines that the first communication request satisfies a coalescing criterion and stores the first communication request in association with a group of requests that have a common property. The communication engine coalesces the group of requests into a coalesced request and transports the coalesced request to the second GPU over a network. |
| FILED | Thursday, June 17, 2021 |
| APPL NO | 17/351002 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 67/12 (20130101) H04L 67/104 (20130101) H04L 67/141 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
U.S. Agency for International Development (USAID)
| US 20220401715 | Terry et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgia Tech Research Corporation (Atlant, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard N. Terry (Atlanta, Georgia); Mark R. Prausnitz (Atlanta, Georgia) |
| ABSTRACT | Methods are provided that involve the intentional and controlled precipitation of a drug or active agent, or a reduction of solubility of a polymer or other film-forming component of a formulation, or a combination of both methods, to improve the processes for making microneedles or other objects by casting into molds and the resulting parts produced by casting. The selective reduction in solubility of formulation components solves many problems associated with the casting of polymer formulations into molds. The methods are preferably adapted for making microneedles of biodegradable polymer and drug composites, and may also be used to produce other solid objects formed by casting into molds of compositions containing polymers and active agents. |
| FILED | Thursday, October 22, 2020 |
| APPL NO | 17/770956 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 37/0015 (20130101) Original (OR) Class A61M 2037/0023 (20130101) A61M 2037/0046 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20220403798 | Shealy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Shealy (Cincinnati, Ohio); Donald M. Corsmeier (West Chester, Ohio) |
| ABSTRACT | In some embodiments, apparatuses are provided herein useful to sealing a gap between a movable flap and a stationary structure, such as a gap between a gas turbine engine nozzle flap and a corresponding sidewall. An apparatus for sealing such a gap may be a dynamic skirted leaf seal which may include a flap arm and a wall arm opposite the flap arm. A distal end portion of the flap arm may comprise a first skirt and the distal end portion of the wall arm may comprise a second skirt that engages the first skirt. When positioned in a gap between the movable flap and the stationary structure, the skirted leaf seal may exert a force to urge the flap arm towards the flap and to urge the wall arm towards the structure to seal the gap. |
| FILED | Monday, June 21, 2021 |
| APPL NO | 17/352605 |
| CURRENT CPC | Jet-propulsion Plants F02K 1/805 (20130101) Original (OR) Class F02K 1/1207 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2240/57 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, December 22, 2022.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20221222.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
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