FedInvent™ Patent Applications
Application Details for Thursday, December 29, 2022
This page was updated on Saturday, December 31, 2022 at 05:43 PM GMT
Department of Health and Human Services (HHS)
| US 20220409166 | Kim et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Kang Kim (Pittsburgh, Pennsylvania); Ahmed M. Mahmoud (Giza, Egypt); Debaditya Dutta (Pittsburgh, Pennsylvania) |
| ABSTRACT | A method for quantifying an amount of fat contained in a liver or other tissue of a subject in vivo includes varying the temperature of a target area in a subject, imaging thermal strain of the target area using an ultrasound scanner, and quantifying the amount of fat in the targeted area based on the thermal strain imaging. In some embodiments, the thermal strain imaging is performed using high-resolution, phase-sensitive speckle tracking to differentiate between fat-based tissue and water-based tissue. |
| FILED | Thursday, September 01, 2022 |
| APPL NO | 17/929080 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0095 (20130101) A61B 5/4872 (20130101) A61B 8/08 (20130101) Original (OR) Class A61B 8/48 (20130101) A61B 8/485 (20130101) A61B 8/4416 (20130101) A61B 8/5223 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220409404 | Yang et al. |
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| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhi Yang (Minneapolis, Minnesota); Anh Tuan Nguyen (Minneapolis, Minnesota); Diu Khue Luu (Minneapolis, Minnesota) |
| ABSTRACT | A neurostimulator incorporating a novel chip design that uses the principle of redundant signal crossfiring to overcome electronic component mismatch error in general and transistor mismatch error in particular, to yield superior quality neurostimulation signal generation, useful in enhancing the bidirectional human-machine interface in prosthesis operation for the restoration of somatosensation for an amputee. |
| FILED | Friday, June 24, 2022 |
| APPL NO | 17/849534 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/72 (20130101) Original (OR) Class A61F 2/583 (20130101) A61F 2002/5061 (20130101) Systems for Regulating Electric or Magnetic Variables G05F 3/262 (20130101) Coding; Decoding; Code Conversion in General H03M 1/66 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220409527 | SFEIR |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania) |
| INVENTOR(S) | Charles S. SFEIR (Wexford, Pennsylvania) |
| ABSTRACT | The present invention relates to systems and methods for the treatment of conditions of chronic inflammation, such as periodontitis, that includes the use of sustained release microparticles to locally deliver a compound or agent to reduce inflammation of tissue, such as periodontal tissue, and/or inflammatory mediators. The microparticles are loaded with a compound or agent selected from the group consisting of C-C motif chemokine ligand 2 (CCL2), interleukin 4 (IL-4), anti-interleukin 17 (IL17 antibody), and mixtures or blends thereof |
| FILED | Thursday, January 21, 2021 |
| APPL NO | 17/787672 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0063 (20130101) Original (OR) Class A61K 9/1647 (20130101) A61K 38/195 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/02 (20180101) Peptides C07K 16/244 (20130101) C07K 16/247 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220409535 | Batrakova et al. |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
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| INVENTOR(S) | Elena V. Batrakova (Durham, North Carolina); Alexander V. Kabanov (Chapel Hill, North Carolina); Marina Sokolsky (Chapel Hill, North Carolina); Matthew J. Haney (Chapel Hill, North Carolina); Dongfen Yuan (Chapel Hill, North Carolina); Myung Soo Kim (Chapel Hill, North Carolina) |
| ABSTRACT | The present invention relates to compositions comprising exosomes and biological agents and methods of using the compositions for the delivery of biological agents to cells and to subjects. |
| FILED | Tuesday, August 23, 2022 |
| APPL NO | 17/821576 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/127 (20130101) Original (OR) Class A61K 31/337 (20130101) A61K 31/7088 (20130101) A61K 45/06 (20130101) A61K 47/65 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220409539 | Gala et al. |
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| FUNDED BY |
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| APPLICANT(S) | Fraunhofer USA Inc. (Newark, Delaware) |
| ASSIGNEE(S) | Fraunhofer USA Inc. (Newark, Delaware) |
| INVENTOR(S) | Rikhav Praful Gala (Newark, Delaware); Robert Mark Jones (Springfield, Pennsylvania); Konstantin Musiychuk (Hockessin, Delaware); Kevin Lawrence Stecca (Middletown, Delaware); Stephen John Streatfield (Kennett Square, Pennsylvania) |
| ABSTRACT | Particles offering multiple doses of an active agent to a subject via a single administration of the active agent to the subject are provided. The particles comprise multiple layers, including two dosing layers each having the active agent and an intervening layer that separates the two dosing layers, and provide a first dose of the active agent from the dosing layer covering the intervening layer upon exposure to an aqueous environment after the particles are administered to the subject, and later a second dose of the active agent from the dosing layer covered by the intervening layer after the intervening layer degrades in the body of the subject. Methods for preparing the particles are also provided. Methods for treating or preventing a disease or disorder in a subject in need thereof with two or more doses of an active agent via a single administration to the subject are further provided. |
| FILED | Wednesday, December 30, 2020 |
| APPL NO | 17/778505 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/167 (20130101) Original (OR) Class A61K 39/07 (20130101) A61K 39/39 (20130101) A61K 2039/55577 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220409559 | WAN et al. |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| INVENTOR(S) | Derrick C. WAN (Stanford, California); Michael T. LONGAKER (Stanford, California); Geoffrey C. GURTNER (Stanford, California) |
| ABSTRACT | Methods of reducing skin fibrosis by prophylactically treating skin prior to radiation therapy are described herein. The methods include applying an effective amount of DFO to skin that may be subjected to radiation, e.g., during treatment for cancer at a treatment site. The DFO may be administered transdermally. |
| FILED | Tuesday, October 20, 2020 |
| APPL NO | 17/778802 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) A61K 31/16 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220409564 | SNODGRASS et al. |
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| APPLICANT(S) | VISTAGEN THERAPUETICS, INC. (South San Francisco, California) |
| ASSIGNEE(S) | VISTAGEN THERAPUETICS, INC. (South San Francisco, California) |
| INVENTOR(S) | H. Ralph SNODGRASS (South San Francisco, California); Allen E. CATO (Durham, North Carolina); Jack S. HICKLIN (San Diego, California) |
| ABSTRACT | Compositions of L-4-chlorokynurenine are provided, as are methods for the treatment of neurological dysfunction. |
| FILED | Tuesday, June 21, 2022 |
| APPL NO | 17/845105 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 31/198 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220409576 | KIM et al. |
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| APPLICANT(S) | KENT STATE UNIVERSITY (Kent, Ohio) |
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| INVENTOR(S) | Min-Ho KIM (Hudson, Ohio); Songping D. HUANG (Kent, Ohio); Bing YU (Stow, Ohio) |
| ABSTRACT | Novel biocompatible Fenton-catalytic nano-particulate composites preferably based on nanoparticle (NP)-based catalysts, one or more reducing agents, and one or more peroxide compounds are formulated to take advantage of their ability to stimulate bactericidal as well as anti-tumor immune response by means of eliciting the generation of reactive oxygen species (ROS) in immune cells, in particular, in macrophages. The therapeutic composition can serve as a treatment for wound infections by, but not limited to, Staphylococcus aureus, Pseudomonas aeruginosa, Staphylococcus epidermidis, Klebsiella pneumoniae, and Acinetobacter baumannii, as a wound/lesion dressing that provide an anti-bacterial immune environment for the accelerated wound healing. In a similar principle, the therapeutic composition can serve as a treatment for solid tumors by providing an anti-tumor immune environment that inhibits tumor growth. |
| FILED | Wednesday, November 18, 2020 |
| APPL NO | 17/765262 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1611 (20130101) A61K 31/365 (20130101) A61K 31/366 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220409602 | Daadi |
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| APPLICANT(S) | TEXAS BIOMEDICAL RESEARCH INSTITUTE (San Antonio, Texas) |
| ASSIGNEE(S) | TEXAS BIOMEDICAL RESEARCH INSTITUTE (San Antonio, Texas) |
| INVENTOR(S) | Marcel M. Daadi (San Antonio, Texas) |
| ABSTRACT | Provided here are arylpiperazine pharmacophore compositions that mitigate levodopa-induced dyskinesia and significantly improve Parkinson's disease-like symptoms. These dopamine D3 receptor ligands have high affinity and selectivity, are orally active, and have desirable drug-like properties. |
| FILED | Tuesday, June 14, 2022 |
| APPL NO | 17/840563 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4535 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220409611 | Brody et al. |
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| APPLICANT(S) | Thomas Jefferson University (Philadelphia, Pennsylvania) |
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| INVENTOR(S) | Jonathan R. Brody (Philadelphia, Pennsylvania); Christopher William Schultz (Riverton, New Jersey) |
| ABSTRACT | Described herein are compositions of pyrvinium salts suitable for oral administration. These compositions are in the form of solutions and demonstrate bioavailability both in blood plasma and in pancreatic tissue. Also described herein are methods of treating, ameliorating, and/or preventing pancreatic cancer, including orally administering a composition comprising pyrvinium pamoate. |
| FILED | Wednesday, October 21, 2020 |
| APPL NO | 17/770515 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4725 (20130101) Original (OR) Class A61K 47/14 (20130101) A61K 47/44 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220409617 | Edinger |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Aimee Edinger (Irvine, California) |
| ABSTRACT | Methods of treatment of metabolic disorders with various compounds are provided. Subjects having a metabolic can be administered a sphingolipid-like compound, an ARF6 antagonist, or a PIKfyve antagonist. Formulations and medicaments are utilized to formulate therapeutics that can be administered to individuals as pharmaceutically effective salt or in pure form, including, but not limited to, formulations for oral, intravenous, or intramuscular administration. |
| FILED | Friday, November 13, 2020 |
| APPL NO | 17/756013 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/40 (20130101) A61K 31/175 (20130101) A61K 31/506 (20130101) Original (OR) Class A61K 31/519 (20130101) A61K 31/4196 (20130101) A61K 31/5377 (20130101) A61K 31/5415 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/04 (20180101) A61P 3/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220409648 | Milbrandt et al. |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey Milbrandt (St. Louis, Missouri); Aaron DiAntonio (St. Louis, Missouri); Tong Wu (St. Louis, Missouri); Amy Strickland (St. Louis, Missouri); Adam Bloom (St. Louis, Missouri); Yo Sasaki (St. Louis, Missouri); Jian Zhu (St. Louis, Missouri); Yurie Yamada (St. Louis, Missouri) |
| ABSTRACT | Among the various aspects of the present disclosure is the provision is the provision of a SARM1 activating agent or prodrug thereof and methods of using same. |
| FILED | Tuesday, June 28, 2022 |
| APPL NO | 17/851954 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/706 (20130101) Original (OR) Class A61K 31/4402 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220409661 | Schmitt et al. |
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| APPLICANT(S) | Fred Hutchinson Cancer Research Center (Seattle, Washington) |
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| INVENTOR(S) | Thomas M. Schmitt (Seattle, Washington); Aude G. Chapuis (Seattle, Washington); Philip D. Greenberg (Mercer Island, Washington) |
| ABSTRACT | The present disclosure provides binding proteins specific for human Wilms tumor protein 1 (WT-1) epitopes, as well as host cells that express the binding proteins. Also provided are polynucleotides that encode a binding protein and vectors that comprise a polynucleotide. Related methods and uses of the presently disclosed compositions are provided for treating diseases or disorders associated with WT-1 expression, such as various cancers. |
| FILED | Wednesday, August 19, 2020 |
| APPL NO | 17/636314 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220409664 | Skinner et al. |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
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| INVENTOR(S) | Pamela J. Skinner (Minneapolis, Minnesota); Mary S. Pampusch (Minneapolis, Minnesota) |
| ABSTRACT | Methods and compositions are described that can be used as a pre-treatment for HIV therapies. |
| FILED | Wednesday, June 29, 2022 |
| APPL NO | 17/809742 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 35/17 (20130101) Original (OR) Class A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Peptides C07K 16/2803 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220409666 | Lim et al. |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); The Trustees of Princeton University (Princeton, New Jersey); The Simons Foundation, Inc. (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wendell A. Lim (San Francisco, California); Olga G. Troyanskaya (Princeton, New Jersey); Benjamin VanderSluis (New York, New York); Ruth Dannenfelser (Princeton, New Jersey) |
| ABSTRACT | The present disclosure provides an immune cell genetically modified to produce two antigen triggered polypeptides, each recognizing a different cell surface antigen. The present disclosure provides a system two antigen-triggered polypeptides, each recognizing a different cell surface antigen. The present disclosure provides a method of killing a target cancer cell, using a genetically modified immune cell or a system of the present disclosure. The present disclosure provides a computational method to identify target N antigen pairs on a cancer cell. |
| FILED | Thursday, June 23, 2022 |
| APPL NO | 17/848313 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 38/177 (20130101) A61K 38/1774 (20130101) A61K 38/1793 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/705 (20130101) C07K 14/7051 (20130101) C07K 16/28 (20130101) C07K 2317/73 (20130101) C07K 2317/622 (20130101) C07K 2319/01 (20130101) C07K 2319/03 (20130101) C07K 2319/30 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 5/0638 (20130101) C12N 2501/42 (20130101) C12N 2510/00 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/20 (20190201) Information and Communication Technology [ICT] Specially Adapted for Specific Application Fields, Not Otherwise Provided for G16Z 99/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220409674 | Caballero |
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| APPLICANT(S) | Vedanta Biosciences, Inc. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Vedanta Biosciences, Inc. (Cambridge, Massachusetts) |
| INVENTOR(S) | Silvia Caballero (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein are compositions and methods for suppressing pathogenic organisms. Also provided herein are compositions and methods for inducing regulatory T-cells in response to pathogenic organisms and methods of treating a disease or disorder associated with bacterial colonization. Also provided herein are methods of suppressing colonization of the intestine of a subject with oral microbiome bacteria. |
| FILED | Friday, August 07, 2020 |
| APPL NO | 17/633930 |
| CURRENT CPC | Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 33/135 (20160801) Preparations for Medical, Dental, or Toilet Purposes A61K 35/741 (20130101) Original (OR) Class A61K 35/742 (20130101) A61K 35/745 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220409692 | Pritchard, Jr. et al. |
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| APPLICANT(S) | The Medical College of Wisconsin (Milwaukee, Wisconsin); Reneurogen LLC (Elm Grove, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kirkwood Arthur Pritchard, Jr. (Elm Grove, Wisconsin); Dustin Paul Martin (Sturtevant, Wisconsin); Stephen Naylor (Elm Grove, Wisconsin) |
| ABSTRACT | As new class of drugs designated systems chemico-pharmacology drugs (SCPD) is disclosed. SCPDs work by targeting a druggable biomolecular site (the first target), resulting in a significant change in the properties of the first target. In the process, the SCPD itself is chemically modified. Subsequently, the resulting modified SCPD interacts with a second target, which is also modified in a manner that is beneficial for the patient. |
| FILED | Wednesday, November 11, 2020 |
| APPL NO | 17/775473 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220409695 | Popova et al. |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Antonia Popova (Ann Arbor, Michigan); Tracy Xiao Cui (Ann Arbor, Michigan) |
| ABSTRACT | The present disclosure provides methods, uses, and pharmaceutical compositions with utility in the treatment of acute lung injuries or chronic lung diseases including, bronchopulmonary dysplasia and exacerbations of bronchopulmonary dysplasia. |
| FILED | Friday, November 20, 2020 |
| APPL NO | 17/778634 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220409702 | BALU-IYER et al. |
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| APPLICANT(S) | The Research Foundation for The State University of New York (Amherst, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sathy V. BALU-IYER (Amherst, New York); Vincent CHAK (Amherst, New York) |
| ABSTRACT | Provided are methods for preventing, treating, suppressing type 1 diabetes, or reversing one or more symptoms of T1D, or delaying the onset of T1D comprising administration to a subject a composition comprising liposomes and insulin intercalated in the bilayer of the liposomes, wherein the bilayer comprises lyso-PS. |
| FILED | Monday, November 23, 2020 |
| APPL NO | 17/779072 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1271 (20130101) A61K 38/28 (20130101) Original (OR) Class A61K 47/544 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220409714 | Lowry et al. |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher A. Lowry (Boulder, Colorado); Matthew G. Frank (Lousville, Colorado); Laura Fonken (Austin, Texas); Steven F. Maier (Boulder, Colorado) |
| ABSTRACT | Methods of treating or preventing stress, anxiety, or postoperative cognitive dysfunction. Also provided are methods of improving resilience in a subject by administering a therapeutically effective amount of isolated mycobacterium. |
| FILED | Monday, August 22, 2022 |
| APPL NO | 17/821354 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/741 (20130101) A61K 39/04 (20130101) Original (OR) Class A61K 2039/521 (20130101) Peptides C07K 14/35 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220409716 | Keller et al. |
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| FUNDED BY |
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| APPLICANT(S) | Children's National Medical Center (Washington, District of Columbia); The United States of America, as represented by the Secretary, Dept. of Health and Human Service (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Keller (Laurel, Maryland); Catherine Mary Bollard (Bethesda, Maryland); Ryo Hanajiri (Bethesda, Maryland); Gelina Sani (Washington, District of Columbia); Lisbeth Kim Green (Olney, Maryland); Jeff Cohen (Silver Spring, Maryland); Stanislav V. Sosnovtsev (North Potomac, Maryland) |
| ABSTRACT | The present disclosure provides adoptive T-cell compositions, therapies, and processes of manufacture that are tailored for treatment or prevention of a subject with a norovirus infection, and, in some embodiments, for those subjects who are candidates for hematopoietic stem cell treatments, subjects who have undergone hematopoietic stem cell treatments, and subjects that have, are diagnosed with or suspected of having primary immunodeficiency disorders. |
| FILED | Thursday, September 24, 2020 |
| APPL NO | 17/763548 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class A61K 2039/572 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220409722 | Pravetoni et al. |
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| FUNDED BY |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota); HENNEPIN HEALTHCARE RESEARCH INSTITUTE (Minneapolis, Minnesota); RTI INTERNATIONAL (Research Park, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marco Pravetoni (Minneapolis, Minnesota); Scott Runyon (Research Park, North Carolina) |
| ABSTRACT | This disclosure describes a fentanyl hapten, a fentanyl hapten-carrier conjugate, methods of making the fentanyl hapten and the fentanyl hapten-carrier conjugate, and methods of using the fentanyl hapten and the fentanyl hapten-carrier conjugate. The fentanyl hapten-carrier conjugate may be used, for example, as a prophylactic vaccine to counteract toxicity from exposure to fentanyl and its analogues. In some embodiments, the fentanyl hapten-carrier conjugate or a composition including the fentanyl hapten-carrier conjugate may be used in an anti-opioid vaccine. |
| FILED | Friday, November 06, 2020 |
| APPL NO | 17/774906 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0013 (20130101) A61K 39/385 (20130101) Original (OR) Class A61K 2039/6081 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 39/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220409731 | Gray et al. |
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| FUNDED BY |
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| APPLICANT(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| INVENTOR(S) | Nathanael S. Gray (Boston, Massachusetts); John M. Hatcher (Boston, Massachusetts); Chelsea E. Powell (Brookline, Massachusetts); Pasi A. Janne (Needham, Massachusetts) |
| ABSTRACT | Disclosed are bispecific compounds (degraders) that target ALK for degradation. Also disclosed are pharmaceutical compositions containing the degraders and methods of using the compounds to treat diseases and disorders characterized or mediated by aberrant ALK activity |
| FILED | Thursday, September 26, 2019 |
| APPL NO | 17/278093 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/55 (20170801) A61K 47/555 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220409746 | Segura et al. |
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| FUNDED BY |
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| APPLICANT(S) | DUKE UNIVERSITY (Durham, North Carolina) |
| ASSIGNEE(S) | DUKE UNIVERSITY (Durham, North Carolina) |
| INVENTOR(S) | Tatiana Segura (Durham, North Carolina); Evan Kurt (Durham, North Carolina) |
| ABSTRACT | The present disclosure provides, in part, nucleic acid loaded flowable hydrogels and compositions, systems and methods related thereto, to effectively deliver nucleic acids to cells that contact the flowable hydrogels. |
| FILED | Wednesday, July 15, 2020 |
| APPL NO | 17/627440 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5036 (20130101) A61K 48/0041 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/85 (20130101) C12N 2830/48 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220409750 | Matsunaga et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Terry O. Matsunaga (Tucson, Arizona); Pedro Alcaraz (Tucson, Arizona); Russell S. Witte (Tucson, Arizona) |
| ABSTRACT | The present disclosure provides novel modified nanodroplets with a layerby-layer (LBL) assembly formulation (“LBLnNDs”). The LBLnNDs of the present disclosure comprise gaseous perfluorocarbon core, polymer shell, and multiple alternating positively and negatively charged biopolymer layers dispersed layerby-layer onto the shell of the LBLnNDs. Methods of making and use of the LBLnNDs are also provided. |
| FILED | Friday, November 20, 2020 |
| APPL NO | 17/778733 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/227 (20130101) Original (OR) Class Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220409772 | Guelcher et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott A. Guelcher (Nashville, Tennessee); Sichang Lu (Nashville, Tennessee); Madison A.P. McGough (Nashville, Tennessee); Katarzyna J. Zienkiewicz (Nashville, Tennessee) |
| ABSTRACT | A hybrid composite and method for producing a polymer network are provided. The hybrid composite includes nanocrystalline hydroxyapatite (nHA) and polyurethane. The method for producing a polymer network includes reacting nanocrystalline hydroxyapatite (nHA) particles with lysine derived triisocyanate (LTI) to form a nHA/LTI hybrid prepolymer and reacting the prepolymer with a thioketal (TK) diol to form a nHA/poly(thioketal urethane) (PTKUR) hybrid polymer network. |
| FILED | Thursday, April 07, 2022 |
| APPL NO | 17/715829 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 2207/20 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/10 (20130101) A61L 27/18 (20130101) A61L 27/20 (20130101) A61L 27/26 (20130101) A61L 27/46 (20130101) A61L 27/48 (20130101) Original (OR) Class A61L 27/54 (20130101) A61L 27/56 (20130101) A61L 27/58 (20130101) A61L 2300/404 (20130101) A61L 2300/412 (20130101) A61L 2300/604 (20130101) A61L 2400/06 (20130101) A61L 2400/12 (20130101) A61L 2430/02 (20130101) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 26/16 (20130101) C04B 2111/00836 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/10 (20130101) C08G 18/771 (20130101) C08G 18/3868 (20130101) C08G 18/4833 (20130101) C08G 18/8061 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220409773 | SHIMODA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MOCHIDA PHARMACEUTICAL CO., LTD. (Tokyo, Japan); NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE (Tokyo, Japan) |
| ASSIGNEE(S) | MOCHIDA PHARMACEUTICAL CO., LTD. (Tokyo, Japan); NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE (Tokyo, Japan) |
| INVENTOR(S) | Masayuki SHIMODA (Tokyo, Japan); Kumiko AJIMA (Tokyo, Japan); Shoji FURUSAKO (Tokyo, Japan) |
| ABSTRACT | Provided is a transplantation device comprising a hydrogel in which insulin-secreting cells or pancreatic islets are enclosed, wherein the hydrogel is prepared by gelatinizing an alginic acid derivative by a chemical crosslinkage. Thus, a novel transplantation device is provided. |
| FILED | Friday, June 26, 2020 |
| APPL NO | 17/620918 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/20 (20130101) A61L 27/52 (20130101) Original (OR) Class A61L 27/3804 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220409774 | Manto et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kristen Manto (Hummelstown, Pennsylvania); John Elfar (Hummelstown, Pennsylvania) |
| ABSTRACT | This document relates to compositions containing one or more erythropoietin (EPO) polypeptides. For example, this document provides thermoresponsive compositions containing one or more EPO polypeptides and methods for using such thermoresponsive compositions as a delivery system to deliver one or more EPO polypeptides to desired tissue (e.g., to treat a nerve injury and/or a wound). In some cases, thermoresponsive compositions containing one or more EPO polypeptides can be administered (e.g., locally administered) to a mammal having a nerve injury to treat the nerve injury (e.g., to promote wound healing). In some cases, thermoresponsive compositions containing one or more EPO polypeptides can be administered (e.g., locally administered) to a mammal having a wound to treat the wound (e.g., to promote wound healing). |
| FILED | Monday, April 25, 2022 |
| APPL NO | 17/728582 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/52 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/02 (20180101) Peptides C07K 14/575 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411366 | Sheppard et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); ShangPharma Innovation Inc. (South San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dean Sheppard (Oakland, California); William F. DeGrado (San Francisco, California); Aparna Sundaram (San Francisco, California); Hyunil Jo (Lafayette, California); Richard Beresis (San Francisco, California); Marc Adler (Orinda, California) |
| ABSTRACT | Disclosed herein, inter alia, are inhibitors of alpha 2 beta 1 integrin and methods of using the same. |
| FILED | Friday, April 30, 2021 |
| APPL NO | 17/246014 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/06 (20180101) Acyclic or Carbocyclic Compounds C07C 275/24 (20130101) C07C 275/26 (20130101) Original (OR) Class Heterocyclic Compounds C07D 205/04 (20130101) C07D 213/73 (20130101) C07D 217/02 (20130101) C07D 217/06 (20130101) C07D 239/84 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411377 | Silverman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard B. Silverman (Winnetka, Illinois); Maris A. Cinelli (Evanston, Illinois); Cory T. Reidl (Northfield, Illinois) |
| ABSTRACT | Disclosed are 7-phenyl-2-aminoquinoline compounds that are shown to inhibit the biological activity of neuronal nitric oxide synthases (nNOSs). Also disclosed are pharmaceutical compositions comprising the compounds, and methods of using the compounds and pharmaceutical compositions for treating a subject in need thereof. Because the disclosed compounds are shown to inhibit the activity of neuronal nitric oxide synthases (nNOSs), the disclosed compounds and pharmaceutical compositions may be utilized in methods for treating a subject having or at risk for developing a disease or disorder that is associated with nNOS activity including neurological diseases and disorders. |
| FILED | Monday, October 26, 2020 |
| APPL NO | 17/770352 |
| CURRENT CPC | Heterocyclic Compounds C07D 215/38 (20130101) Original (OR) Class C07D 401/04 (20130101) C07D 401/12 (20130101) C07D 413/12 (20130101) C07D 417/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411378 | COX et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (Atlanta, Georgia); ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert COX (Decatur, Georgia); Richard PLEMPER (Decatur, Georgia); Benhur LEE (New York, New York) |
| ABSTRACT | Disclosed herein are compounds using for inhibiting RNA polymerase, especially viral RNA polymerase. The compounds are effective for the treatment of viruses in Paramyxoviridae family, especially measles and human parainfluenza virus. |
| FILED | Tuesday, September 15, 2020 |
| APPL NO | 17/776934 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Heterocyclic Compounds C07D 217/02 (20130101) Original (OR) Class C07D 217/14 (20130101) C07D 239/88 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411390 | BLACKWELL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Helen E. BLACKWELL (Middleton, Wisconsin); Grant D. GESKE (Madison, Wisconsin); Jennifer C. CAMPBELL BUTLER (Wayland, Wisconsin) |
| ABSTRACT | The present invention provides compounds and methods for modulation of the quorum sensing of bacteria. In an embodiment, the compounds of the present invention are able to act as replacements for naturally occurring bacterial quorum sensing ligands in a ligand-protein binding system; that is, they imitate the effect of natural ligands and produce an agonistic effect. In another embodiment, the compounds of the present invention are able to act in a manner which disturbs or inhibits the naturally occurring ligand-protein binding system in quorum sensing bacteria; that is, they produce an antagonistic effect. The compounds of the present invention comprise N-acylated-homoserine lactones (AHLs) comprised of a wide range of acyl groups. |
| FILED | Monday, January 24, 2022 |
| APPL NO | 17/582858 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/365 (20130101) Heterocyclic Compounds C07D 307/32 (20130101) C07D 307/33 (20130101) Original (OR) Class C07D 309/30 (20130101) C07D 333/32 (20130101) C07D 405/12 (20130101) C07D 407/12 (20130101) C07D 409/12 (20130101) C07D 413/12 (20130101) C07D 417/12 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/36 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411396 | Renslo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam Robert Renslo (Oakland, California); Brian Richard Blank (Daly City, California); Ryan Keith Muir (Colma, California); Michael John Evans (South San Francisco, California); Poulami Talukder (Cambridge, Massachusetts) |
| ABSTRACT | Disclosed herein, inter alia, are trioxolane compounds and methods of using the same for treatment and detection of diseases. |
| FILED | Friday, February 25, 2022 |
| APPL NO | 17/680825 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 33/06 (20180101) Heterocyclic Compounds C07D 323/02 (20130101) Original (OR) Class C07D 405/12 (20130101) C07D 407/12 (20130101) C07D 413/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411401 | Ghosh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arun K. Ghosh (West Lafayette, Indiana); Hiroaki Mitsuya (Kumamoto, Japan); Andrew Mesecar (West Lafayette, Indiana); Dana Shahabi (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arun K. Ghosh (West Lafayette, Indiana); Hiroaki Mitsuya (Kumamoto, Japan); Andrew Mesecar (West Lafayette, Indiana); Dana Shahabi (West Lafayette, Indiana) |
| ABSTRACT | Bis-amide inhibitors of SARS-CoV-2 (COVID); pharmaceutical compositions comprising same; and methods of treating a severe acute respiratory syndrome. |
| FILED | Monday, May 23, 2022 |
| APPL NO | 17/751659 |
| CURRENT CPC | Heterocyclic Compounds C07D 401/12 (20130101) Original (OR) Class C07D 401/14 (20130101) C07D 413/12 (20130101) C07D 413/14 (20130101) C07D 417/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411404 | Scott et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David A. Scott (Newton, Massachusetts); David Heppner (Brookline, Massachusetts); Thomas Gero (Stow, Massachusetts); Courtney A. Cullis (Bedford, Massachusetts); Ciric To (Medford, Massachusetts); Shih-Chung Huang (Lexington, Massachusetts); Yongbo Hu (Winchester, Massachusetts); Steve Stroud (Cambridge, Massachusetts); Tyler Beyett (Brookline, Massachusetts); Michael Eck (Brookline, Massachusetts); Nathanael S. Gray (Jamaica Plain, Massachusetts) |
| ABSTRACT | The disclosure relates to compounds that act as allosteric inhibitors of epidermal growth factor receptor (EGFR); pharmaceutical compositions comprising the compounds; and methods of treating or preventing kinase-mediated disorders, including cancer and other proliferation diseases. |
| FILED | Tuesday, May 10, 2022 |
| APPL NO | 17/741206 |
| CURRENT CPC | Heterocyclic Compounds C07D 401/14 (20130101) Original (OR) Class C07D 471/04 (20130101) C07D 473/00 (20130101) C07D 495/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411407 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaodong Wang (Chapel Hill, North Carolina); Yubai Zhou (Cary, North Carolina); Ransheng Ding (Binhai New District, China PRC); Deyu Kong (Chapel Hill, North Carolina); Stephen Frye (Chapel Hill, North Carolina) |
| ABSTRACT | Aminopyrimidine containing compounds that inhibit both Mer tyrosine kinase (MerTK) activity and Tyro3 kinase activity are disclosed herein. Additionally disclosed are methods of synthesis and use of the aminopyrimidine containing compounds as anti-cancer agents, immunostimulatory and immunomodulatory agents, anti-platelet agents, anti-infective agents, and as adjunctive agents. |
| FILED | Friday, November 13, 2020 |
| APPL NO | 17/755908 |
| CURRENT CPC | Heterocyclic Compounds C07D 401/04 (20130101) C07D 401/14 (20130101) Original (OR) Class C07D 405/14 (20130101) C07D 413/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411419 | LAMA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RetroVirox, Inc. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Juan LAMA (San Diego, California); Robert I. HIGUCHI (Solana Beach, California); Richard MARTIN (San Diego, California); Maria Isabel CISNEROS (San Diego, California) |
| ABSTRACT | The invention disclosed herein are embodiments of compounds capable of treating a viral infection. For example, the compounds are capable of inhibiting viral downmodulation of major histocompatibility complex I (MHC-I), such as by acting as immunomodulators of the immune system to treat, cure or eradicate a viral infection (e.g., HIV infection). More particularly, the present disclosure relates to the use of a heteroaryl compound or salts or analogs thereof, in the treatment of patients infected with a virus. The disclosed compounds may be used alone or in combination with other pharmacologically active agents to treat, cure or eradicate the virus, particularly in patients with persistent, latent viral infection. In some embodiments, the disclosed compounds can be used alone or in combination with other pharmacologically active agents to promote reactivation of viral production in latent cells and eradication of such cells. |
| FILED | Wednesday, May 01, 2019 |
| APPL NO | 17/052930 |
| CURRENT CPC | Heterocyclic Compounds C07D 277/60 (20130101) C07D 405/12 (20130101) C07D 405/14 (20130101) C07D 417/12 (20130101) C07D 417/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411426 | Maianti et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Juan Pablo Maianti (Cambridge, Massachusetts); David R. Liu (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein are compounds of Formulae (RL), (I), (II), (HI), (IV), and (V), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, prodrugs, and isotopically labeled derivatives thereof. Also provided are pharmaceutical compositions, kits, and methods involving the inventive compounds for the treatment of metabolic disorders (e.g., diabetes, hyperglycemia, impaired glucose tolerance, insulin resistance, obesity). The compound are useful as substrate selective inhibitors of insulin-degrading enzyme (IDE). |
| FILED | Wednesday, May 12, 2021 |
| APPL NO | 17/318672 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/00 (20180101) Acyclic or Carbocyclic Compounds C07C 311/16 (20130101) Heterocyclic Compounds C07D 205/04 (20130101) C07D 211/14 (20130101) C07D 211/16 (20130101) C07D 211/96 (20130101) C07D 241/44 (20130101) C07D 295/26 (20130101) C07D 295/185 (20130101) C07D 401/06 (20130101) C07D 401/12 (20130101) C07D 405/06 (20130101) C07D 405/12 (20130101) C07D 413/06 (20130101) C07D 413/12 (20130101) C07D 487/04 (20130101) Original (OR) Class C07D 487/08 (20130101) C07D 493/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411472 | Stoddard et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Fred Hutchinson Cancer Center (Seattle, Washington) |
| ASSIGNEE(S) | Fred Hutchinson Cancer Center (Seattle, Washington) |
| INVENTOR(S) | Barry L. Stoddard (Seattle, Washington); Philip Bradley (Seattle, Washington); Colin E. Correnti (Seattle, Washington) |
| ABSTRACT | Circular handed alpha-helical repeat proteins are described. The repeat proteins have a number of uses as scaffolds for geometrically precise, arrayed presentation of cell-signaling or immune-related protein and peptide epitopes, as well as numerous other therapeutic, diagnostic, and nanotechnological uses. |
| FILED | Thursday, July 02, 2020 |
| APPL NO | 17/624208 |
| CURRENT CPC | Peptides C07K 7/08 (20130101) C07K 14/001 (20130101) Original (OR) Class C07K 2319/60 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411475 | MILICH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VLP Biotech, Inc. (San Diego, California) |
| ASSIGNEE(S) | VLP Biotech, Inc. (San Diego, California) |
| INVENTOR(S) | David R. MILICH (San Diego, California); David C. WHITACRE (San Diego, California) |
| ABSTRACT | The present disclosure relates to hybrid hepadnavirus core antigens including one or more epitopes of a human hepatitis B vims (HBV) antigen. More specifically, the present disclosure relates to hybrid hepadnavirus core antigens in the form of fusion proteins containing a fragment of the PreS1 region of the HBV surface antigen inserted in a woodchuck hepadnavirus core antigen. The present disclosure further relates to hybrid hepadnavirus core antigens in the form of fusions proteins containing a truncated HBV core antigen and woodchuck hepadnavirus core antigen. Also provided are nucleic acids encoding the hybrid core antigens, and the use of the hybrid core antigens and nucleic acids for treating HBV-infected individuals. |
| FILED | Friday, November 13, 2020 |
| APPL NO | 17/777589 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 2039/5258 (20130101) Peptides C07K 14/02 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/74 (20130101) C12N 15/79 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411478 | Maus et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Marcela V. Maus (Lexington, Massachusetts); Mark Leick (Boston, Massachusetts) |
| ABSTRACT | Provided herein are CD70 targeting chimeric antigen receptors and engineered immune cells (e.g., T cells) comprising such CAR. Method of treating a cancer expressing CD70 using such engineered immune cells are also provided. In some embodiments, the method of treating cancer further comprising using an agent that enhances CD70 expression in the cancer (e.g., azacitidine) in combination with the engineered immune cells comprising the CD70-targeting CAR. |
| FILED | Wednesday, September 16, 2020 |
| APPL NO | 17/761131 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Peptides C07K 14/7051 (20130101) Original (OR) Class C07K 16/2875 (20130101) C07K 16/2878 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8645 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411485 | Holtzman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri); Denali Therapeutics Inc. (South San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Holtzman (St. Louis, Missouri); Hong Jiang (St. Louis, Missouri); Fan Liao (St. Louis, Missouri); Thu Nga Bien-Ly (South San Francisco, California); Mark S. Dennis (South San Francisco, California); Jing Guo (South San Francisco, California); Adam P. Silverman (South San Francisco, California); Ryan J. Watts (South San Francisco, California); Yin Zhang (South San Francisco, California) |
| ABSTRACT | The present disclosure encompasses compositions and methods for effectively treating at least one symptom or sign of Aß plaque or cerebral amyloid angiopathy (CAA) associated symptoms, or for decreasing amyloid plaque load or CAA load. The method comprises administering an effective amount of an anti-ApoE antibody to a mammalian subject, such as to a human. |
| FILED | Tuesday, August 24, 2021 |
| APPL NO | 17/410686 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0085 (20130101) A61K 9/127 (20130101) A61K 31/192 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Peptides C07K 16/18 (20130101) Original (OR) Class C07K 2317/33 (20130101) C07K 2317/90 (20130101) C07K 2317/92 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411490 | Hotamisligil et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (, None) |
| INVENTOR(S) | Gokhan S. Hotamisligil (Weston, Massachusetts); Kosei Eguchi (Brookline, Massachusetts) |
| ABSTRACT | Provided herein are compounds, compositions, and methods of identifying compounds that neutralize the ability of the cannabinoid receptor type-1 (CB1) agonist 2-arachidonylglycerol (2-AG) in complex with its obligate binding partner adipocyte lipid binding protein (aP2) from agonizing CB1 signaling in peripheral tissues. Further provided herein are methods of treating a disorder associated with dysregulated or abnormal hepatic de novo lipogenesis and/or hepatic selective insulin resistance by inhibiting cannabinoid receptor type-1 (CB1) agonist 2-arachidonylglycerol (2-AG) in complex with its obligate binding partner adipocyte lipid binding protein (aP2) from binding and agonizing CB1. |
| FILED | Thursday, May 26, 2022 |
| APPL NO | 17/825697 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) A61P 3/04 (20180101) A61P 3/10 (20180101) Peptides C07K 16/18 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411496 | Krummel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Matthew Krummel (San Francisco, California); Miranda Broz (San Francisco, California); Denise Wolf (San Francisco, California); Joshua Pollack (San Francisco, California); Mikhail Binnewies (San Francisco, California) |
| ABSTRACT | Provided herein are methods and compositions for enhancing an immune response and/or for the treatment of an immune-related condition in an individual, e.g., cancer, comprising killing, disabling, or depleting non-stimulatory myeloid cells using an antigen binding protein such as an antibody or antigen binding fragment thereof. |
| FILED | Tuesday, April 05, 2022 |
| APPL NO | 17/714051 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Peptides C07K 16/30 (20130101) C07K 16/243 (20130101) C07K 16/2803 (20130101) Original (OR) Class C07K 16/2818 (20130101) C07K 16/2863 (20130101) C07K 16/3046 (20130101) C07K 16/3053 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0626 (20130101) C12N 5/0639 (20130101) C12N 5/0645 (20130101) C12N 5/0693 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56966 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411500 | Wernig |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gerlinde Wernig (Woodside, California) |
| ABSTRACT | Compositions and methods are provided for reducing fibrosis in a mammal by administering a therapeutic dose of a combination of agents to block interleukin-6 (IL-6), and an immune checkpoint inhibitor; wherein the checkpoint inhibitor comprising an agent that blocks programmed cell death protein 1 (PD1), blocks PD1 ligand 1 (PDL1), or blocks CD47/SIRPa pathway. |
| FILED | Wednesday, November 18, 2020 |
| APPL NO | 17/776201 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/03 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/04 (20180101) Peptides C07K 16/248 (20130101) C07K 16/2803 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411508 | LIU et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bin LIU (San Francisco, California); Shanshan LANG (San Francisco, California); Yang SU (San Francisco, California); Scott BIDLINGMAIER (San Francisco, California); Nam-Kyung LEE (San Francisco, California) |
| ABSTRACT | The present disclosure relates generally to compositions and methods useful for the production of engineered antibodies having (i) multiple antigen-binding specificities and (ii) Fc regions that have been modified to promote heterodimer formation between heavy chains from antibodies with different specificities. Also provided are recombinant cells, recombinant nucleic acids encoding such engineered antibodies, as well as pharmaceutical compositions containing same. |
| FILED | Wednesday, September 09, 2020 |
| APPL NO | 17/639225 |
| CURRENT CPC | Peptides C07K 16/2818 (20130101) Original (OR) Class C07K 16/2827 (20130101) C07K 16/2896 (20130101) C07K 2317/21 (20130101) C07K 2317/55 (20130101) C07K 2317/92 (20130101) C07K 2317/526 (20130101) C07K 2319/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411518 | JULIA et al. |
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| FUNDED BY |
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| APPLICANT(S) | GALDERMA HOLDING S.A. (Zug, Switzerland); Chugai Seiyaku Kabushiki Kaisha (Tokyo, Japan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Valerie JULIA (Biot, France); Jayendra Kumar KRISHNASWAMY (Pully, Switzerland); Christophe PIKETTY (Montargis, France); Francois ROUSSEAU (Publier, France) |
| ABSTRACT | Described herein are treatments and preventions for prurigo nodularis (PN), antibodies and pharmaceutical compositions for use in the treatment or prevention of PN, and uses of an anti-IL-31RA antibody (e.g., nemolizumab) in the manufacture of a medicament for the treatment or prevention of PN. Also described herein are biomarkers of PN and methods of altering or improving these biomarkers via treatments with an antibody that binds to IL-31RA (e.g., nemolizumab). |
| FILED | Wednesday, April 06, 2022 |
| APPL NO | 17/714847 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/04 (20180101) Peptides C07K 16/2866 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411527 | PENICHET et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); KLYSS BIOTECH, INC. (Beverly Hills, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); KLYSS BIOTECH, INC. (Beverly Hills, California) |
| INVENTOR(S) | Manuel L. PENICHET (Los Angeles, California); Tracy R. WELLS (Los Angeles, California); Pierre V. CANDELARIA (Los Angeles, California); Juan C. ALMAGRO (Beverly Hills, California) |
| ABSTRACT | Aspects of the disclosure relate to transferrin receptor 1 (TfR1)-binding proteins. In some cases, humanized TfR1-binding proteins are described. Embodiments include methods for treating one or more conditions, for example cancer, using a humanized TfR1-binding protein. In some embodiments, the disclosed methods and compositions involve one or more antibodies that are capable of binding TfR1. Certain aspects relate to humanized antibodies and antibody-like molecules comprising one or more amino acid substitutions (e.g., backmutations). Additional aspects relate to combination treatments with TfR1-binding proteins and one or more additional therapeutics. |
| FILED | Friday, November 06, 2020 |
| APPL NO | 17/775167 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/3955 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2881 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/94 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411751 | Butovsky et al. |
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| FUNDED BY |
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| APPLICANT(S) | Oleg BUTOVSKY (Boston, Massachusetts); Vladimir LITVAK (Holden, Massachusetts); William RALVENIUS (Somerville, Massachusetts); Li-Huei TSAI (Cambridge, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts); University of Massachusetts (Boston, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Oleg Butovsky (Boston, Massachusetts); Vladimir Litvak (Holden, Massachusetts); William Ralvenius (Somerville, Massachusetts); Li-Huei Tsai (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein are methods for obtaining populations of reprogrammed MO-homeostatic tolerogenic microglial cells. The methods include providing an initial population of monocytes, e.g., peripheral blood monocytes (PBMC), from a subject, and reprogramming the cells by maintaining the PBMC in culture ex vivo in the presence of a sufficient amount of transforming growth factor-beta (TGFβ) and interferon-gamma (IFNγ) for a time and under conditions sufficient for the cells to become M0-homeostatic tolerogenic microglia. Also provided are methods of use of these cells, e.g., for the treatment of neurodegenerative diseases associated with inflammation, e.g., Alzheimer's Disease (AD); Multiple Sclerosis (MS), e.g., progressive MS; and Amyotrophic Lateral Sclerosis |
| FILED | Friday, November 20, 2020 |
| APPL NO | 17/778270 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/30 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0622 (20130101) Original (OR) Class C12N 2501/15 (20130101) C12N 2501/24 (20130101) C12N 2506/115 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411757 | Palecek et al. |
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| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sean Palecek (Verona, Wisconsin); Martha Floy (Madison, Wisconsin) |
| ABSTRACT | The disclosure generally relates to methods for generating cardiac fibroblast cells from epicardial cardiac progenitor cells, populations of cardiac fibroblast cells and uses thereof. |
| FILED | Thursday, June 09, 2022 |
| APPL NO | 17/836693 |
| CURRENT CPC | Peptides C07K 14/503 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0656 (20130101) Original (OR) Class C12N 5/0657 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5044 (20130101) G01N 33/48728 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411763 | O'Shea et al. |
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| FUNDED BY |
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| APPLICANT(S) | Salk Institute for Biological Studies (La Jolla, California) |
| ASSIGNEE(S) | Salk Institute for Biological Studies (La Jolla, California) |
| INVENTOR(S) | Clodagh O'Shea (San Diego, California); Colin Powers (San Diego, California) |
| ABSTRACT | Methods of assembling modified adenoviruses, libraries of adenoviral gene modules and compositions thereof are provided herein. |
| FILED | Friday, February 25, 2022 |
| APPL NO | 17/681538 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class C12N 15/86 (20130101) C12N 15/861 (20130101) C12N 2710/10043 (20130101) C12N 2710/10051 (20130101) C12N 2710/10351 (20130101) C12N 2800/30 (20130101) C12N 2800/70 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411777 | Joung et al. |
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| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | J. Keith Joung (Winchester, Massachusetts); Ibrahim Cagri Kurt (Chelsea, Massachusetts); Ronghao Zhou (Charlestown, Massachusetts); Julian Grunewald (Charlestown, Massachusetts) |
| ABSTRACT | Engineered transversion base editors that enable expanded amino acid modifications and methods of using the same. Described herein, for example, are fusion proteins containing cytidine deaminases (e.g. human or rat APOBECs, pmCDA1 or AID) or adenosine deaminases (e.g. E. coli TadAs) or a combination thereof, catalytically impaired CRISPR-Cas proteins (e.g. Cas9, CasX or Cas12 nucleases), linkers, nuclear localization signals (NLSs) and a human or E. coli uracil-n-glycosylase (UNG) and/or REV1 protein that enable the CRISPR-guided programmable introduction of C-to-G and G-to-C transversions in DNA. The UNG may be fused to the deaminase-Cas fusion or not, in which case endogenous UNG may be recruited using molecular machinery that is integrated into the deaminase-Cas fusion architecture, e.g. using peptide or RNA aptamers or scFVs, sdABs or Fabs. |
| FILED | Monday, August 31, 2020 |
| APPL NO | 17/638157 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/78 (20130101) Original (OR) Class C12N 15/102 (20130101) Enzymes C12Y 305/04005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411778 | Wang |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Lei Wang (San Francisco, California) |
| ABSTRACT | Provided herein are novel materials and methods for site-specific incorporation of phosphotyrosines into proteins. The novel methods of the invention encompass the use of a novel aminoacyl tRNA synthetase capable of charging compatible tRNAs with a phosphotyrosine precursor. The phosphotyrosine precursor is then incorporated, site-specifically, into a protein at sites where phosphotyrosine residues are desired. The phosphotyrosine precursors are subsequently treated to convert them into phosphotyrosine residues, yielding proteins with phosphotyrosines at selected sites. The scope of the invention encompasses novel aminoacyl tRNA synthetases, novel phosphotyrosine precursors, and methods of using these materials to create site-specific phosphorylated tyrosine residues in a protein. |
| FILED | Wednesday, August 10, 2022 |
| APPL NO | 17/818919 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/12 (20130101) C07F 9/242 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/88 (20130101) Original (OR) Class C12N 9/93 (20130101) C12N 15/52 (20130101) C12N 15/63 (20130101) C12N 2310/314 (20130101) Enzymes C12Y 601/01026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411783 | Regev et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aviv Regev (Cambridge, Massachusetts); Cristin McCabe (Cambridge, Massachusetts); Eugene Drokhlyansky (Cambridge, Massachusetts); Alexandre Melnikov (Cambridge, Massachusetts); Orit Rozenblatt-Rosen (Cambridge, Massachusetts); Christopher S. Smillie (Cambridge, Massachusetts); Ramnik J. Xavier (Cambridge, Massachusetts); Orr Ashenberg (Cambridge, Massachusetts); Gökcen Eraslan (Cambridge, Massachusetts); Hattie Chung (Cambridge, Massachusetts) |
| ABSTRACT | The subject matter disclosed herein is generally directed to isolating single cells and nuclei from tissue samples for use in the analysis of single cells from archived biological samples. The subject matter disclosed herein is directed to isolating single cells and nuclei from formalin-fixed paraffin-embedded (FFPE) tissues. The subject matter disclosed herein is also directed to isolating single nuclei that preserve ribosomes or ribosomes and rough ER from frozen tissues. The subject matter disclosed herein is also directed to therapeutic targets, diagnostic targets and methods of screening for modulating agents. |
| FILED | Friday, October 11, 2019 |
| APPL NO | 17/284542 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0081 (20130101) C12N 15/1017 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/34 (20130101) G01N 1/44 (20130101) G01N 1/286 (20130101) G01N 15/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411787 | Yang et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California) |
| INVENTOR(S) | Xiangdong William Yang (LOS ANGELES, California); Matthew B. Veldman (LOS ANGELES, California) |
| ABSTRACT | Constructs and methods are described for producing sparse and stochastic labeling of cells expressing one or more site-specific recombinases in a host mammal. Described is a nucleic acid construct comprising, in operable linkage, a translation start site, an optional spacer, a polycytosine mononucleotide repeat, and an open reading frame (ORF), wherein the polycytosine repeat and the ORF are out of frame with respect to the translation start site. The simple, general, and scalable solution for genetically-directed sparse cell labeling allows the visualization of the complete cellular morphology of cells. Representative examples of cells to be visualized using sparse labeling include, but are not limited to, neurons or non-neuronal cells in the central nervous system (including brain), peripheral nervous systems, and other peripheral tissues. |
| FILED | Monday, November 23, 2020 |
| APPL NO | 17/756336 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/907 (20130101) C12N 15/1065 (20130101) Original (OR) Class C12N 2800/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411790 | Zou et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Roger Zou (Baltimore, Maryland); Yang Liu (Baltimore, Maryland); Taekjip Ha (Baltimore, Maryland) |
| ABSTRACT | A gene-editing system includes an engineered photocleavable guide RNA to endow Cas9 nuclease and base editing activities with a built-in mechanism for fast, light-mediated deactivation. In methods of use, the system retains high editing efficiency, natively improves specificity, offers precise spatial and temporal control, improves base editing purity through early deactivation. |
| FILED | Sunday, October 25, 2020 |
| APPL NO | 17/770531 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) Original (OR) Class C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411797 | GLACKIN et al. |
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| FUNDED BY |
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| APPLICANT(S) | City of Hope (Duarte, California); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carlotta A. GLACKIN (Duarte, California); John ROSSI (Azusa, California); Jeffrey I. ZINK (Los Angeles, California); Fuyuhiko TAMANOI (Los Angeles, California); Cai M. ROBERTS (Duarte, California); James FINLAY (Duarte, California) |
| ABSTRACT | The present invention relates to compositions comprising TWIST signaling inhibitors and optionally one or more anti-cancer agents, and methods of using the compositions for the treatment of cancer. |
| FILED | Friday, June 24, 2022 |
| APPL NO | 17/849294 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6923 (20170801) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/14 (20130101) C12N 2310/321 (20130101) C12N 2310/322 (20130101) C12N 2310/332 (20130101) C12N 2310/335 (20130101) C12N 2310/351 (20130101) C12N 2320/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411798 | Martin et al. |
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| FUNDED BY |
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| APPLICANT(S) | Baylor College of Medicine (Houston, Texas); Texas Heart Institute (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James F. Martin (Pearland, Texas); Yuka Morikawa (Houston, Texas); Todd Ryan Heallen (Houston, Texas); John Leach (Houston, Texas) |
| ABSTRACT | Embodiments of the disclosure include methods and compositions for the renewal of cardiomyocytes by targeting the Hippo pathway. In particular embodiments, an individual with a need for cardiomyocyte renewal is provided an effective amount of a shRNA molecule that targets the Sav1 gene. Particular shRNA sequences are disclosed. |
| FILED | Monday, September 12, 2022 |
| APPL NO | 17/931270 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/531 (20130101) C12N 2320/30 (20130101) C12N 2740/15043 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411806 | Lynch et al. |
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| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Lynch (Durham, North Carolina); Romel Menacho Melgar (Durham, North Carolina); Zhixia Ye (Raleigh, North Carolina); Eirik A. Moreb (Durham, North Carolina) |
| ABSTRACT | Improved production of recombinant proteins in E. coli, reliant on tightly controlled autoinduction, triggered by phosphate depletion in stationary phase. The process also provides an optimized autoinduction media, enabling routine batch production at various culture volumes where cells densities routinely reach ˜5-7 g cell dry weight per liter and offer protein titers above 2 g/L. The methodology has been validated with a set of diverse heterologous proteins and is of general use for the facile optimization of routine protein expression from high throughput screens to fed-batch fermentation. |
| FILED | Friday, October 23, 2020 |
| APPL NO | 17/755158 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 15/70 (20130101) C12N 15/635 (20130101) Original (OR) Class C12N 2500/14 (20130101) C12N 2500/16 (20130101) C12N 2500/24 (20130101) C12N 2500/42 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411821 | Wang et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| INVENTOR(S) | Eric Tzy-Shi Wang (Gainesville, Florida); John Andrew Berglund (Menands, New York); Elizabeth Delgado (Gainesville, Florida); Jana Rose Jenquin (Gainesville, Florida) |
| ABSTRACT | Provided herein, in some embodiments, are nucleic acid constructs encoding RNA molecules comprising one or more introns that can be regulated (e.g., autoregulated), and that are useful for delivery in a recombinant viral vector. Aspects of the application provide compositions and methods for delivering regulated (e.g., auto-regulated) gem expression constructs to a subject. |
| FILED | Wednesday, October 28, 2020 |
| APPL NO | 17/772266 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/0066 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 2750/14143 (20130101) C12N 2830/42 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411822 | PSATHA et al. |
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| FUNDED BY |
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| APPLICANT(S) | ALTIUS INSTITUTE FOR BIOMEDICAL SCIENCES (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | NIKOLETA PSATHA (Seattle, Washington); JEFF VIERSTA (Seattle, Washington); GRIGORIOS GEORGOLOPOULOS (Seattle, Washington); JOHN A. STAMATOYANNOPOULOS (Seattle, Washington) |
| ABSTRACT | Provided herein are expression cassettes comprising at least one copy of an enhancer element, wherein the enhancer element comprises or consists essentially of a nucleotide sequence at least 50% identical to any one of SEQ ID NOs: 1-10 and vectors comprising the expression cassettes. Also provided herein are cells transduced with the expression cassettes or the vectors. Further described herein are pharmaceutical compositions comprising an effective amount of one or more of: the cell, the expression cassette, or the vector of this disclosure. Also disclosed herein are methods of treating a hemoglobinopathy in a subject, comprising administering an effective amount of the pharmacological compositions described herein. |
| FILED | Friday, January 22, 2021 |
| APPL NO | 17/793793 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/62 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 2740/16043 (20130101) C12N 2830/15 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411826 | Cavener et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Douglas R. Cavener (University Park, Pennsylvania); Jingjie Hu (University Park, Pennsylvania); Barbara C. McGrath (University Park, Pennsylvania); Rebecca A. Bourne (University Park, Pennsylvania) |
| ABSTRACT | The present application discloses methods of correcting a gene defect in a cell, methods of treating a patient having a disease or disorder characterized by a gene defect, methods of preparing a chimeric antigen receptor T cell, as well as systems for correcting a gene defect in a cell, ex vivo modified cells, and related compositions. |
| FILED | Tuesday, June 21, 2022 |
| APPL NO | 17/845447 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/907 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411863 | ZHANG et al. |
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| FUNDED BY |
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| APPLICANT(S) | William Marsh Rice University (Houston, Texas) |
| ASSIGNEE(S) | William Marsh Rice University (Houston, Texas) |
| INVENTOR(S) | David Yu ZHANG (Houston, Texas); Deepak THIRUNAVUKARASU (Houston, Texas); Yuxuan CHENG (Houston, Texas); Ping SONG (Houston, Texas) |
| ABSTRACT | Provided herein are compositions and methods for assembling multiple DNA molecules into a linear concatemer, with applications to nanopore sequencing of DNA sequence variations. |
| FILED | Wednesday, November 25, 2020 |
| APPL NO | 17/779689 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6869 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411865 | Drmanac |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Complete Genomics, Inc. (San Jose, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Radoje Drmanac (Los Altos Hills, California) |
| ABSTRACT | This disclosure provides technology for ordering sequence information derived from one or more target polynucleotides. In one aspect, one or more tiers or levels of fragmentation and aliquoting are generated, after which sequence information is obtained from fragments in a final level or tier. Each fragment in such final tier is from a particular aliquot, which, in turn, is from a particular aliquot of a prior tier, and so on. For every fragment of an aliquot in the final tier, the aliquots from which it was derived at every prior tier is known, or can be discerned. Thus, identical sequences from overlapping fragments from different aliquots can be distinguished and grouped as being derived from the same or different fragments from prior tiers. When the fragments in the final tier are sequenced, overlapping sequence regions of fragments in different aliquots are used to register the fragments so that non-overlapping regions are ordered. In one aspect, this process is carried out in a hierarchical fashion until the one or more target polynucleotides are characterized, e.g. by their nucleic acid sequences, or by an ordering of sequence segments, or by an ordering of single nucleotide polymorphisms (SNPs), or the like. |
| FILED | Thursday, July 14, 2022 |
| APPL NO | 17/864913 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/04 (20130101) Peptides C07K 1/047 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/682 (20130101) C12Q 1/6806 (20130101) C12Q 1/6837 (20130101) C12Q 1/6869 (20130101) C12Q 1/6874 (20130101) Original (OR) Class C12Q 2525/151 (20130101) C12Q 2525/313 (20130101) C12Q 2531/125 (20130101) C12Q 2565/513 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1404 (20130101) G01N 15/1434 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/88 (20130101) Y10S 977/778 (20130101) Y10S 977/789 (20130101) Y10S 977/792 (20130101) Y10S 977/882 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411866 | Drmanac |
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| FUNDED BY |
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| APPLICANT(S) | Complete Genomics, Inc. (San Jose, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Radoje Drmanac (Los Altos Hills, California) |
| ABSTRACT | This disclosure provides technology for ordering sequence information derived from one or more target polynucleotides. In one aspect, one or more tiers or levels of fragmentation and aliquoting are generated, after which sequence information is obtained from fragments in a final level or tier. Each fragment in such final tier is from a particular aliquot, which, in turn, is from a particular aliquot of a prior tier, and so on. For every fragment of an aliquot in the final tier, the aliquots from which it was derived at every prior tier is known, or can be discerned. Thus, identical sequences from overlapping fragments from different aliquots can be distinguished and grouped as being derived from the same or different fragments from prior tiers. When the fragments in the final tier are sequenced, overlapping sequence regions of fragments in different aliquots are used to register the fragments so that non-overlapping regions are ordered. In one aspect, this process is carried out in a hierarchical fashion until the one or more target polynucleotides are characterized, e.g. by their nucleic acid sequences, or by an ordering of sequence segments, or by an ordering of single nucleotide polymorphisms (SNPs), or the like. |
| FILED | Thursday, July 14, 2022 |
| APPL NO | 17/864916 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/04 (20130101) Peptides C07K 1/047 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/682 (20130101) C12Q 1/6806 (20130101) C12Q 1/6837 (20130101) C12Q 1/6869 (20130101) C12Q 1/6874 (20130101) Original (OR) Class C12Q 2525/151 (20130101) C12Q 2525/313 (20130101) C12Q 2531/125 (20130101) C12Q 2565/513 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1404 (20130101) G01N 15/1434 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/88 (20130101) Y10S 977/778 (20130101) Y10S 977/789 (20130101) Y10S 977/792 (20130101) Y10S 977/882 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220412635 | Closs et al. |
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| FUNDED BY |
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| APPLICANT(S) | MiTeGen, LLC (Ithaca, New York) |
| ASSIGNEE(S) | MiTeGen, LLC (Ithaca, New York) |
| INVENTOR(S) | David Closs (Freeville, New York); Stephen Hollabaugh (Ithaca, New York); Robert E. Thorne (Ithaca, New York); Robert Newman (Groton, New York); Benjamin A. Apker (Ithaca, New York) |
| ABSTRACT | A cryogenic cooling manifold and methods incorporating a cryogenic cooling manifold for managing the gas layer(s) above a liquid cryogen to control cooling temperature-time profiles and ice formation for microliter and smaller samples that are plunged through the gas and into the liquid cryogen. |
| FILED | Thursday, September 01, 2022 |
| APPL NO | 17/901050 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0252 (20130101) Refrigerators; Cold Rooms; Ice-boxes; Cooling or Freezing Apparatus Not Otherwise Provided for F25D 3/10 (20130101) Original (OR) Class F25D 2400/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220412955 | SILVA et al. |
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| FUNDED BY |
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| APPLICANT(S) | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aristo S. SILVA (Tampa, Florida); Kenneth SHAIN (Saint Petersburg, Florida); Praneeth SUDALAGUNTA (Tampa, Florida); Rafael Renatino CANEVAROLO (Tampa, Florida); Mark MEADS (Tampa, Florida) |
| ABSTRACT | Disclosed is a method of detecting synergistic drug combinations for the treatment of a cancer, comprising: culturing infected cells in a chamber: contacting the cells in with a first active agent; measuring and/or estimating the concentration of the first active agent at a first and second time point; capturing a first and second optical signal from the contacted cells at the first and second time points; analyzing the first optical signal and the second optical signal to detect cell membrane motion of the cells; analyzing the cell membrane motion to quantify the viability of the cells following contact with the first active agent thereby detecting the drug induced damage at the second time point; measuring, calculating, and/or estimating the repair rate of the cells, therapeutic threshold, rate of sensitivity of therapy, and/or clonal composition of the tumor; repeating said steps with a second active agent. |
| FILED | Wednesday, November 25, 2020 |
| APPL NO | 17/779870 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5011 (20130101) Original (OR) Class G01N 2500/10 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 7/20 (20130101) G06T 2207/30096 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220412978 | Pass et al. |
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| FUNDED BY |
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| APPLICANT(S) | New York University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Harvey I. Pass (Bronxville, New York); Chandra M. Goparaju (Cliffside, New Jersey) |
| ABSTRACT | Provided are methods for aiding in diagnosis and treatment of non-small cell lung cancer (NSCLC) adenocarcinoma. The methods involve determining elevated circulating Interleukin-18 (IL-18) values to aid in the diagnosis and treatment of NSCLC. Medical interventions based on determining circulating IL-18 levels are provided and include additional scanning, surgical resection of tumors, and administration of adjuvant therapy, such as chemotherapy or immune therapy. |
| FILED | Thursday, June 23, 2022 |
| APPL NO | 17/808379 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 33/243 (20190101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57423 (20130101) Original (OR) Class G01N 33/57484 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220412980 | Shah et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ami A. Shah (Ellicott City, Maryland); Livia Casciola-Rosen (Pikesville, Maryland); Antony Rosen (Pikesville, Maryland); Takeru Igusa (Baltimore, Maryland); Marikki K. Laiho (Kauniainen, Finland) |
| ABSTRACT | This document relates to materials and methods for assessing and/or treating subjects (e.g., subjects having autoimmune diseases). For example, materials and methods for determining if a subject (e.g., a human having an autoimmune disease) has one or more antibodies that can be used to identify the subject as having a lower risk of cancer or as having a higher risk of cancer are provided. Materials and methods for treating a subject (e.g., a human) identified as having a higher cancer risk for cancer are also provided. |
| FILED | Thursday, August 18, 2022 |
| APPL NO | 17/890695 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/564 (20130101) G01N 33/57488 (20130101) Original (OR) Class G01N 2800/24 (20130101) G01N 2800/7028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220412989 | STOCKWELL et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brent R. STOCKWELL (New York, New York); Angie Huizhong FENG (New York, New York) |
| ABSTRACT | The present disclosure provides, inter alia, methods for identifying cells undergoing non-apoptotic cell death, e.g., ferroptosis, in a subject, using anti-TfR1 antibodies such as 3F3-FMA. Methods for treating or ameliorating the effects of a cancer in a subject, methods for enhancing the anti-tumor effect of radiation in a subject with cancer undergoing radiotherapy, and compositions and kits comprising anti-TfR1 antibodies disclosed herein are also provided. |
| FILED | Thursday, August 04, 2022 |
| APPL NO | 17/817601 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2881 (20130101) C07K 2317/567 (20130101) C07K 2317/622 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6872 (20130101) Original (OR) Class G01N 33/57492 (20130101) G01N 2333/70582 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220412993 | Rahme et al. |
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| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts); University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Laurence Rahme (Brookline, Massachusetts); Amy Tsurumi (Boston, Massachusetts); Patrick Flaherty (Amherst, Massachusetts); Colleen M. Ryan (Winchester, Massachusetts) |
| ABSTRACT | Described herein are methods that use blood biomarkers to identify an increased risk of multiple independent infection episodes (MIIE) before clinical signs of infection appear. Thus, provided herein are methods for detecting or predicting risk of developing multiple independent infection episodes (MIIE) in a subject who has experienced blunt trauma. |
| FILED | Monday, December 07, 2020 |
| APPL NO | 17/781646 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) Original (OR) Class G01N 2800/26 (20130101) G01N 2800/60 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220413078 | Trzasko et al. |
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| FUNDED BY |
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| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joshua D. Trzasko (Rochester, Minnesota); Uten Yarach (Rochester, Minnesota); Matthew A. Bernstein (Rochester, Minnesota); Myung-Ho In (Rochester, Minnesota); Yi Sui (Rochester, Minnesota) |
| ABSTRACT | Nyquist ghost artifacts in echo planar imaging (“EPI”) are mitigated, reduced, or otherwise eliminated by implementing robust Nyquist ghost correction (“NGC”) directly from two reversed readout EPI acquisitions. As one advantage, these techniques do not require explicit reference scanning A model-based process is used for directly estimating statistically optimal NGC coefficients from multi-channel k-space data. |
| FILED | Tuesday, December 01, 2020 |
| APPL NO | 17/781660 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/5616 (20130101) G01R 33/56554 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220413388 | Aviel et al. |
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| FUNDED BY |
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| APPLICANT(S) | MIRACLON CORPORATION (Oakdale, Minnesota) |
| ASSIGNEE(S) | MIRACLON CORPORATION (Oakdale, Minnesota) |
| INVENTOR(S) | David Aviel (Minneapolis, Minnesota); Fredrick Charles Mellema (Oakdale, Minnesota); Andrew R. Williams (Buffalo, Minnesota) |
| ABSTRACT | A processing system for processing a flexographic printing plate can include a processing path for processing the flexographic printing plate. A hollow tube can be positioned to be extended across the processing path. A pressurized processing liquid supply system is provided. A plurality of pressure-compensating emitters are coupled to the hollow tube Each pressure-compensating emitter can include a casing having a fluidic flow path that is fluidly coupled with the hollow tube and having an outlet. Also, each emitter can include a resilient planar member in the casing and positioned to form at least one resilient surface of the fluidic flow path. Each pressure-compensating emitter is configured to control flow rate of the pressurized processing liquid to produce processing liquid drips from the outlet. The resilient planar member can be positioned to provide a variable outlet cross-sectional profile to the outlet in response to pressure inside the casing. |
| FILED | Tuesday, August 23, 2022 |
| APPL NO | 17/893782 |
| CURRENT CPC | Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/0015 (20130101) G03F 7/3057 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220414076 | Bagchi et al. |
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| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Saurabh Bagchi (West Lafayette, Indiana); Somali Chaterji (West Lafayette, Indiana); Ashraf Mahgoub (West Lafayette, Indiana); Paul Curtis Wood (Lafayette, Indiana) |
| ABSTRACT | A system may forecast a plurality of workload measurements for a database management system (DBMS) at respective times based on a workload model. The system may determine, based on the forecasted workload measurements, configuration parameter sets optimized for the DBMS at the respective times. The system may generate a reconfiguration plan. The system may determine performance that would result from reconfiguring nodes of the DBMS with the configurations parameter sets. The system may select a reconfiguration plan in response to the performance satisfying a fitness criterion. The system may cause, at the reconfiguration times, the nodes to begin reconfiguration with the configuration parameter sets included in the selected reconfiguration plan. |
| FILED | Tuesday, September 06, 2022 |
| APPL NO | 17/903733 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/5083 (20130101) G06F 11/3034 (20130101) G06F 11/3409 (20130101) G06F 16/21 (20190101) G06F 16/25 (20190101) G06F 16/182 (20190101) G06F 16/217 (20190101) Original (OR) Class G06F 16/285 (20190101) G06F 2209/5019 (20130101) Computer Systems Based on Specific Computational Models G06N 3/02 (20130101) G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220414483 | Shen et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Dennis Shen (Irvine, California); Devavrat D. Shah (Waban, Massachusetts); Anish Agarwal (Newton, Massachusetts) |
| ABSTRACT | A computer-implemented method includes: identifying, from first and second data, interventions common to a target unit and one or more of a plurality of donor units as filtered donor units, the first data corresponding to the target unit under one or more interventions, the second data corresponding to the plurality of donor units each under one or more interventions; identifying, from the first data, third data corresponding to the target unit under the common interventions; identifying, from the second data, fourth data corresponding to the filtered donor units under the common interventions; identifying, from the second data, fifth data corresponding to the filtered donor units under a subject intervention; generating, from the third and fourth data, a learned model representing to a relationship between the target unit and the filtered donor units; applying the learned model to the fifth data to generate the synthetic data; and outputting the synthetic data. |
| FILED | Monday, April 11, 2022 |
| APPL NO | 17/658712 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 5/022 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220414953 | Shen et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Liyue Shen (Stanford, California); Lei Xing (Palo Alto, California) |
| ABSTRACT | Image reconstruction is an inverse problem that solves for a computational image based on sampled sensor measurement. Sparsely sampled image reconstruction poses addition challenges due to limited measurements. In this work, we propose an implicit Neural Representation learning methodology with Prior embedding (NeRP) to reconstruct a computational image from sparsely sampled measurements. The method differs fundamentally from previous deep learning-based image reconstruction approaches in that NeRP exploits the internal information in an image prior, and the physics of the sparsely sampled measurements to produce a representation of the unknown subject. No large-scale data is required to train the NeRP except for a prior image and sparsely sampled measurements. In addition, we demonstrate that NeRP is a general methodology that generalizes to different imaging modalities such as CT and MRI. We also show that NeRP can robustly capture the subtle yet significant image changes required for assessing tumor progression. |
| FILED | Wednesday, June 08, 2022 |
| APPL NO | 17/835896 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/0004 (20130101) G06T 11/003 (20130101) Original (OR) Class G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220415308 | BERISHA et al. |
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| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona); Wisconsin Alumni Research Foundation (Madison, Wisconsin); Aural Analytics, Inc. (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Visar BERISHA (Tempe, Arizona); Julie LISS (Scottsdale, Arizona); Katherine HUSTAD (Madison, Wisconsin); Tristan MAHR (Sun Prairie, Wisconsin); Kan KAWABATA (Tempe, Arizona) |
| ABSTRACT | Systems, devices, and methods for tracking articulatory and prosodic development in children are disclosed. Human speech in a given language can be divided into phonemes, which are a sound or group of sounds perceived by speakers of the language to have a common linguistic function (e.g., consonant sounds, vowel sounds). In an exemplary aspect, a normative model can be generated for production characteristics of each phoneme in a given language using a database of normative speech samples. One or more speech samples of a human subject can be analyzed to identify the phonemes used by the human subject and measured against the normative model. Based on this analysis, a normed score is generated of the articulation accuracy, duration, rhythm, volume, and/or other production characteristics for each phoneme of the speech sample of the human subject. |
| FILED | Monday, September 28, 2020 |
| APPL NO | 17/764054 |
| CURRENT CPC | Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 15/02 (20130101) G10L 15/22 (20130101) G10L 15/30 (20130101) G10L 15/187 (20130101) Original (OR) Class G10L 25/18 (20130101) G10L 2015/025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220415438 | Moiso et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Enrico Moiso (Cambridge, Massachusetts); Salil Garg (Wellesley, Massachusetts) |
| ABSTRACT | A computer-implemented method and system uses a map which maps from gene expression data for a plurality of training tumors in a tumor atlas to gene expression data representing single cells derived from mammal samples in developmental stages in a single-cell atlas. The method and system: (A) use the map to extract, from the plurality of training tumors, a plurality of biological components, thereby generating, for each training tumor-biological component pair, a corresponding biological component score; and (B) construct, based on the two atlases and the map, a machine learning perceptron classifier that outputs a tumor type of an input tumor based on its gene expression data. The method and system may generate the map before using it. The method and system may apply the machine learning perceptron classifier to the input tumor's gene expression data to generate the tumor type of the input tumor. |
| FILED | Tuesday, June 28, 2022 |
| APPL NO | 17/852156 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/126 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 25/00 (20190201) Original (OR) Class G16B 40/20 (20190201) G16B 45/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220415439 | Lemmer et al. |
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| FUNDED BY |
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| APPLICANT(S) | Translational Genomics Research Institute (Phoenix, Arizona); Arizona Board of Regents, Acting for and on Behalf of Northern Arizona University (Flagstaff, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Darrin Lemmer (Flagstaff, Arizona); Jolene Bowers (Flagstaff, Arizona); Erin Kelley (Flagstaff, Arizona); David Engelthaler (Flagstaff, Arizona); Elizabeth Driebe (Flagstaff, Arizona); Paul Keim (Flagstaff, Arizona) |
| ABSTRACT | An Amplicon Sequencing Analysis Pipeline (ASAP) system (120, 600) characterizes a genetic sample. The ASAP system (120, 600) receives assay configuration data individually associating reference sequences and genetic characteristics. The ASAP system (120, 600) processes amplicon sequencing data and the reference sequences to characterize the genetic sample based on the individual associations between the reference sequences and the genetic characteristics in the assay configuration data. The ASAP (120, 600) system transfers genetic data indicating the genetic characteristics for the genetic sample and indicating interpretation metrics for amplicon sequencing read depth and quality related to the genetic characteristics. |
| FILED | Wednesday, June 08, 2022 |
| APPL NO | 17/835499 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) G16B 20/20 (20190201) G16B 30/00 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220415444 | Hung et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ling-Hong Hung (Seattle, Washington); Ka Yee Yeung-Rhee (Seattle, Washington) |
| ABSTRACT | In some embodiments, a computer-implemented method of comparing strings representing nucleotide sequences is provided. A plurality of values representing Hamming distances between first strings and second strings are determined by converting value characters in the first string and the second string to a one hot encoding and converting any unknown characters in the first string and the second string to a zero value to create a first bit representation and a second bit representation; comparing the first bit representation and the second bit representation using a bitwise XOR operation to obtain a bitwise XOR result; counting a number of bits in the bitwise XOR result and multiplying the bitwise XOR result by two to obtain a bitcount result; and adjusting the bitcount result based on unknown characters in at least one of the first string and the second string to obtain the value representing the Hamming distance. |
| FILED | Monday, June 27, 2022 |
| APPL NO | 17/850739 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 30/10 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20220408720 | Brassil |
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| FUNDED BY |
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| APPLICANT(S) | John M. Brassil (Lake Mills, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John M. Brassil (Lake Mills, Wisconsin) |
| ABSTRACT | An organ preservation system having; an organ chamber with a perfusate reservoir, a pump arranged to circulate perfusate, from the reservoir and passes the perfusate through a dialysis filter, oxygenator, and temperature and pressure sensors prior to entering the chamber where an organ is perfused. The organ rests on the platform such that perfusate leaving the organ flows into the perfusate reservoir. The dialysis filter having permeable tubes which allow perfusate constituents to be exchanged with dialysate flowing through the dialysis filter. The dialysate pass through an ion exchange resin removing selected constituents or waste products from the dialysate by absorption by the ion exchange resin. Following waste absorption, the dialysate is recycled to the dialyzer to again remove waste. Removing waste products from the perfusate by dialysis followed by removal of the waste products from the dialysate with the exchange resin, enables dialysate reuse for extended duration. |
| FILED | Monday, June 28, 2021 |
| APPL NO | 17/361071 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/021 (20130101) A01N 1/0247 (20130101) Original (OR) Class Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 2/0047 (20130101) A61L 2202/21 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220409062 | Stang et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John P. Stang (South Pasadena, California); Mark S. Haynes (Pasadena, California); Mahta Moghaddam (Los Angeles, California); Guanbo Chen (Los Angeles, California) |
| ABSTRACT | Methods and systems of monitoring and controlling thermal therapy treatments. One method includes determining, with an electronic processor, a propagation constant for a plurality of waveports. The method also includes modeling an object within an imaging cavity using a sparse mesh model. The method also includes determining a simulated impedance of the object based on the model of the object. The method also includes calibrating the simulated impedance with a theoretical impedance numerically calculated for the object. The method also includes determining a distribution of an electric field and a distribution of a magnetic field for a mode in a conformal modeled waveport based on the calibrated impedance and the model of the object. The method also includes exciting the plurality of waveports to generate the determined distribution of the electric field and the distribution of the magnetic field. |
| FILED | Friday, July 15, 2022 |
| APPL NO | 17/865717 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/015 (20130101) Original (OR) Class A61B 5/0036 (20180801) A61B 5/055 (20130101) A61B 5/4836 (20130101) A61B 8/463 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220409298 | HAIDER et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
| ASSIGNEE(S) | Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
| INVENTOR(S) | Hani HAIDER (Carter Lake, Iowa); Ibrahim AL-SHAWI (Amman, Jordan); Osvaldo Andres BARRERA (Omaha, Nebraska) |
| ABSTRACT | A number of improvements are provided relating to computer aided surgery utilizing an on tool tracking system. The various improvements relate generally to both the methods used during computer aided surgery and the devices used during such procedures. Other improvements relate to the structure of the tools used during a procedure and how the tools can be controlled using the OTT device. Still other improvements relate to methods of providing feedback during a procedure to improve either the efficiency or quality, or both, for a procedure including the rate of and type of data processed depending upon a CAS mode. |
| FILED | Sunday, September 04, 2022 |
| APPL NO | 17/902876 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/3132 (20130101) A61B 5/00 (20130101) A61B 5/061 (20130101) A61B 5/1076 (20130101) A61B 17/142 (20161101) A61B 17/1703 (20130101) A61B 34/20 (20160201) Original (OR) Class A61B 34/37 (20160201) A61B 34/76 (20160201) A61B 2034/102 (20160201) A61B 2034/2057 (20160201) A61B 2034/2065 (20160201) A61B 2090/061 (20160201) A61B 2090/064 (20160201) A61B 2090/3983 (20160201) Image Data Processing or Generation, in General G06T 2207/30004 (20130101) Image or Video Recognition or Understanding G06V 2201/034 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220409669 | Lellouch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexandre G. Lellouch (Harrison, New York); Curtis L. Cetrulo (Cohasset, Massachusetts) |
| ABSTRACT | Disclosed herein are nerve xenografts and methods of using such for repairing and/or protecting a nerve tissue in a human patient. The subject matter disclosed herein generally relates to nerve xenografts derived from genetically engineered source animals, and use of such nerve xenografts for repairing and/protecting nerve tissue in a human patient, e.g., for reconstruction of large peripheral nerve gaps, treatment of spinal cord injuries and ailments, and other therapies. |
| FILED | Wednesday, December 02, 2020 |
| APPL NO | 17/781279 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/436 (20130101) A61K 35/30 (20130101) Original (OR) Class A61K 38/13 (20130101) A61K 38/185 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220409774 | Manto et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kristen Manto (Hummelstown, Pennsylvania); John Elfar (Hummelstown, Pennsylvania) |
| ABSTRACT | This document relates to compositions containing one or more erythropoietin (EPO) polypeptides. For example, this document provides thermoresponsive compositions containing one or more EPO polypeptides and methods for using such thermoresponsive compositions as a delivery system to deliver one or more EPO polypeptides to desired tissue (e.g., to treat a nerve injury and/or a wound). In some cases, thermoresponsive compositions containing one or more EPO polypeptides can be administered (e.g., locally administered) to a mammal having a nerve injury to treat the nerve injury (e.g., to promote wound healing). In some cases, thermoresponsive compositions containing one or more EPO polypeptides can be administered (e.g., locally administered) to a mammal having a wound to treat the wound (e.g., to promote wound healing). |
| FILED | Monday, April 25, 2022 |
| APPL NO | 17/728582 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/52 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/02 (20180101) Peptides C07K 14/575 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220410118 | Lundin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Jeffrey G. Lundin (Springfield, Virginia); Christopher L. McGann (Alexandria, Virginia); Spencer L. Giles (Lorton, Virginia); Grant Daniels (Lorton, Virginia); Robert B. Balow (Mount Ranier, Maryland); Jorge L. Miranda-Zayas (Ponce, Puerto Rico); James H. Wynne (Alexandria, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Jeffrey G. Lundin (Springfield, Virginia); Christopher L. McGann (Alexandria, Virginia); Spencer L. Giles (Lorton, Virginia); Grant Daniels (Lorton, Virginia); Robert B. Balow (Mount Ranier, Maryland); Jorge L. Miranda-Zayas (Ponce, Puerto Rico); James H. Wynne (Alexandria, Virginia) |
| ABSTRACT | Materials for decontamination of compounds having a phosphorous-sulfur bond or a phosphorous-oxygen bond. A porous polymer, such as poly(dicyclopentadiene), contains particles of zirconium hydroxide. The polymer optionally has hydroperoxide groups. |
| FILED | Thursday, August 25, 2022 |
| APPL NO | 17/822361 |
| CURRENT CPC | Chemical Means for Extinguishing Fires or for Combating or Protecting Against Harmful Chemical Agents; Chemical Materials for Use in Breathing Apparatus A62D 3/38 (20130101) A62D 2101/26 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/06 (20130101) Original (OR) Class B01J 20/261 (20130101) B01J 20/3064 (20130101) B01J 20/3085 (20130101) B01J 20/28026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220410122 | FAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| INVENTOR(S) | Xudong FAN (Saline, Michigan); Hongbo ZHU (Johnson City, Tennessee); Jinyan SHE (Ann Arbor, Michigan); Maxwell Wei-Hao LI (Troy, Michigan); Katsuo KURABAYASHI (Ann Arbor, Michigan) |
| ABSTRACT | A gas chromatography device for peak focusing of one or more target analytes is provided that include a chromatographic column with an inlet and an outlet. A stationary phase is deposited inside the chromatographic column and has a positive thickness gradient. The stationary phase extends from the inlet to the outlet and has a first thickness at the inlet of the chromatographic column and a second thickness at the outlet of the chromatographic column. The second thickness is at least about 10% greater than the first thickness. Methods of peak focusing in a gas chromatography device, method of verifying peak focusing in a gas chromatography device and creating a gas chromatography device having a chromatographic column with a positive thickness gradient are also provided. |
| FILED | Wednesday, November 25, 2020 |
| APPL NO | 17/779247 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/285 (20130101) B01J 20/287 (20130101) Original (OR) Class B01J 20/3282 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/6065 (20130101) G01N 30/6078 (20130101) G01N 2030/025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411048 | Di Leo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Claudio V. Di Leo (Atlanta, Georgia); Mark F. Costello (Atlanta, Georgia); Benjamin Leon (Atlanta, Georgia); Julian Jose Rimoli (Atlanta, Georgia); Michael B. Ward (Atlanta, Georgia) |
| ABSTRACT | A leg mechanism includes an articulated leg system, a passive device and a cable. The articulated leg system has a leg portion. The passive device is coupled to the articulated leg system and is configured to apply a first force to a portion thereof. The cable is coupled to the articulated leg system and is configured to apply a second force, in opposition to the first force, to a portion thereof. When the cable is drawn away from the articulated leg system, the second force moves the leg portion in a first direction. When tension is released from the cable, the passive device exerts the first force so as to move the leg portion a second direction that is opposite the first direction. |
| FILED | Monday, August 29, 2022 |
| APPL NO | 17/897761 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 25/001 (20130101) B64C 25/12 (20130101) B64C 25/20 (20130101) Original (OR) Class B64C 25/62 (20130101) B64C 2025/008 (20130101) B64C 2025/125 (20130101) B64C 2025/325 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411268 | Arnold et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Scott Arnold (Middleton, Wisconsin); Austin James Way (Madison, Wisconsin); Robert Michael Jacobberger (Evanston, Illinois) |
| ABSTRACT | Methods for the bottom-up growth of graphene nanoribbons are provided. The methods utilize small aromatic molecular seeds to initiate the anisotropic chemical vapor deposition (CVD) growth of graphene nanoribbons having low size polydispersities on the surface of a growth substrate. The aromatic molecular seeds include polycyclic aromatic hydrocarbons (PAHs), functionalized derivatives of PAHs, heterocyclic aromatic molecules, and metal complexes of heterocyclic aromatic molecules. |
| FILED | Monday, June 28, 2021 |
| APPL NO | 17/360108 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/186 (20170801) Original (OR) Class C01B 2204/065 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2004/17 (20130101) C01P 2004/64 (20130101) Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 29/02 (20130101) C30B 29/54 (20130101) C30B 29/60 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411414 | Ji |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Haitao Ji (Tampa, Florida) |
| ABSTRACT | Disclosed are inhibitors for the β-catenin/BCL9 interaction. The inhibitors are selective for β-catenin/BCL9 over D catenin/cadherin interactions. Methods of using the disclosed compounds to treat cancer are also disclosed. |
| FILED | Wednesday, August 03, 2022 |
| APPL NO | 17/817173 |
| CURRENT CPC | Heterocyclic Compounds C07D 403/14 (20130101) C07D 409/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411482 | Lawrence et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SILK TECHNOLOGIES, LTD. (Plymouth, Minnesota) |
| ASSIGNEE(S) | SILK TECHNOLOGIES, LTD. (Plymouth, Minnesota) |
| INVENTOR(S) | Brian D. Lawrence (Tampa, Florida); David W. Infanger (Maple Grove, Minnesota); Yue Bai (Plymouth, Minnesota); Nicholas Paulson (Roseville, Minnesota) |
| ABSTRACT | A biotherapeutic ophthalmic solution that may include a silk-derived protein as an active ingredient. Ophthalmic formulations are critical to the delivery of dosage forms, user requirements, and maintaining product stability. The formulations described herein are ophthalmic solutions that are comfortable to the user while product stability is maintained, even after long-term storage. Numerous excipients, manufacturing processes, and container closures were evaluated for their ability to stabilize silk-derived protein under ambient and accelerated conditions. Analyses showed that a small sub-set of protein-containing formulations meet the high physiochemical property standards required for therapeutic ophthalmic solutions. |
| FILED | Monday, November 16, 2020 |
| APPL NO | 17/785392 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/26 (20130101) A61K 47/183 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) Peptides C07K 14/78 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411574 | Lai et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Board of Trustees of the Leland Stanford Junior University (A/K/A Stanford University) (Stanford, California); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Holden Wan Hong Lai (Stanford, California); Jun Myun Ahn (Stanford, California); Yan Xia (Stanford, California); Zachary P. Smith (Cambridge, Massachusetts); Francesco M. Benedetti (Cambridge, Massachusetts) |
| ABSTRACT | Disclosed herein are ladder polymers comprising fused aromatic and non-aromatic rings. Also disclosed are the manufacture and use of these ladder polymers, e.g., in separation membranes, such as membrane for gas separation. |
| FILED | Friday, October 23, 2020 |
| APPL NO | 17/771434 |
| CURRENT CPC | Separation B01D 69/02 (20130101) B01D 71/76 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 61/02 (20130101) C08G 61/122 (20130101) Original (OR) Class C08G 2261/344 (20130101) C08G 2261/1336 (20130101) C08G 2261/3142 (20130101) C08G 2261/3242 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411777 | Joung et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | J. Keith Joung (Winchester, Massachusetts); Ibrahim Cagri Kurt (Chelsea, Massachusetts); Ronghao Zhou (Charlestown, Massachusetts); Julian Grunewald (Charlestown, Massachusetts) |
| ABSTRACT | Engineered transversion base editors that enable expanded amino acid modifications and methods of using the same. Described herein, for example, are fusion proteins containing cytidine deaminases (e.g. human or rat APOBECs, pmCDA1 or AID) or adenosine deaminases (e.g. E. coli TadAs) or a combination thereof, catalytically impaired CRISPR-Cas proteins (e.g. Cas9, CasX or Cas12 nucleases), linkers, nuclear localization signals (NLSs) and a human or E. coli uracil-n-glycosylase (UNG) and/or REV1 protein that enable the CRISPR-guided programmable introduction of C-to-G and G-to-C transversions in DNA. The UNG may be fused to the deaminase-Cas fusion or not, in which case endogenous UNG may be recruited using molecular machinery that is integrated into the deaminase-Cas fusion architecture, e.g. using peptide or RNA aptamers or scFVs, sdABs or Fabs. |
| FILED | Monday, August 31, 2020 |
| APPL NO | 17/638157 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/78 (20130101) Original (OR) Class C12N 15/102 (20130101) Enzymes C12Y 305/04005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411806 | Lynch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Lynch (Durham, North Carolina); Romel Menacho Melgar (Durham, North Carolina); Zhixia Ye (Raleigh, North Carolina); Eirik A. Moreb (Durham, North Carolina) |
| ABSTRACT | Improved production of recombinant proteins in E. coli, reliant on tightly controlled autoinduction, triggered by phosphate depletion in stationary phase. The process also provides an optimized autoinduction media, enabling routine batch production at various culture volumes where cells densities routinely reach ˜5-7 g cell dry weight per liter and offer protein titers above 2 g/L. The methodology has been validated with a set of diverse heterologous proteins and is of general use for the facile optimization of routine protein expression from high throughput screens to fed-batch fermentation. |
| FILED | Friday, October 23, 2020 |
| APPL NO | 17/755158 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 15/70 (20130101) C12N 15/635 (20130101) Original (OR) Class C12N 2500/14 (20130101) C12N 2500/16 (20130101) C12N 2500/24 (20130101) C12N 2500/42 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411901 | DiDomizio et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard DiDomizio (Charlton, New York); Andrew Joseph Detor (Albany, New York); James Anthony Ruud (Delmar, New York); Christopher Thomas McLasky (Glenville, New York) |
| ABSTRACT | An oxide dispersion strengthened refractory-based alloy is provided, along with methods of its formation and use. The oxide dispersion strengthened refractory-based alloy may include a refractory-based alloy comprising two or more refractory elements and forming a continuous phase; and a rare earth refractory oxide comprising at least one rare earth element and at least one of the two or more refractory elements. The rare earth refractory oxide forms discrete particles within the continuous phase, and the oxide dispersion strengthened refractory-based alloy comprises 0.1 volume % to 5 volume % of the rare earth refractory oxide. |
| FILED | Tuesday, June 29, 2021 |
| APPL NO | 17/361961 |
| CURRENT CPC | Alloys C22C 1/05 (20130101) C22C 1/0458 (20130101) C22C 27/00 (20130101) Original (OR) Class C22C 30/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220412032 | Lamie et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America as Represented by The Secretary of The Army (Alexandria, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nathan J. Lamie (Hanover, New Hampshire); Leonard Zabilansky (Hanover, New Hampshire); Christopher J. Donnelly (Hanover, New Hampshire); Jordan M. Hodge (Hanover, New Hampshire); William Burch (Hanover, New Hampshire) |
| ABSTRACT | In one embodiment, an ice management system is provided for removing an amount of oil from a surface of a body of water. The ice management system includes an ice frame having an ice fence coupled with an ice cage, an oil skimmer device disposed within the ice frame, and an ice deflection assembly coupled with the ice frame. The ice deflection assembly includes an auger coupled with a motor. The auger includes a drum and a deflection mechanism, and the motor is configured to rotate the auger. The deflection mechanism includes a spiral flight or a series of tabs arranged in a corkscrew pattern about the drum. The ice fence includes a plurality of curved vanes. The curved vanes have a bent rectangular plate shape. |
| FILED | Friday, June 25, 2021 |
| APPL NO | 17/359399 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/40 (20130101) C02F 2101/32 (20130101) Hydraulic Engineering E02B 15/048 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220412077 | Ford et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Thomas Benjamin Ford (Midland City, Alabama); Matthew Janish (Eibert, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas Benjamin Ford (Midland City, Alabama); Matthew Janish (Eibert, Colorado) |
| ABSTRACT | Electromagnetically shielded and self-supporting panels form a shielded enclosure. The use of prefabricated, shielded and self-supporting panels to construct an enclosure reduces the time and cost of constructing such an enclosure. |
| FILED | Friday, June 25, 2021 |
| APPL NO | 17/358710 |
| CURRENT CPC | General Building Constructions; Walls, e.g Partitions; Roofs; Floors; Ceilings; Insulation or Other Protection of Buildings E04B 1/08 (20130101) E04B 1/92 (20130101) Original (OR) Class E04B 2001/925 (20130101) E04B 2103/06 (20130101) Structural Elements; Building Materials E04C 2/08 (20130101) E04C 2/46 (20130101) E04C 2/50 (20130101) E04C 2/322 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/72 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 9/0003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220412222 | Sener et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander Martin Sener (Santa Monica, California); Matthew Mark Weaver (Loveland, Ohio); Lauren Rose Watson (West Chester, Ohio) |
| ABSTRACT | An airfoil assembly defines an axial direction, a radial direction, and a circumferential direction, and includes an airfoil and an outer band disposed on an outer end of the airfoil in the radial direction. The outer band includes an outer attachment structure configured to secure the outer band to an outer support structure on an outer side of the outer band. |
| FILED | Friday, June 25, 2021 |
| APPL NO | 17/358441 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 9/041 (20130101) F01D 9/042 (20130101) Original (OR) Class F01D 25/246 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2240/12 (20130101) F05D 2240/80 (20130101) F05D 2300/6033 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220412422 | Huang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Guoliang Huang (Columbia, Missouri); Hussein Nassar (Columbia, Missouri); Yangyang Chen (Columbia, Missouri); Xianchen Xu (Columbia, Missouri) |
| ASSIGNEE(S) | The Curators of the University of Missouri (Columbia, Missouri) |
| INVENTOR(S) | Guoliang Huang (Columbia, Missouri); Hussein Nassar (Columbia, Missouri); Yangyang Chen (Columbia, Missouri); Xianchen Xu (Columbia, Missouri) |
| ABSTRACT | An elastic wave cloaking lattice-based metamaterial for cloaking an object within a void includes a lattice of connected unit cells arranged to form a void, each unit cell comprising a mass and a plurality of connecting springs, the mass coupled by the plurality of connecting springs to masses in adjacent unit cells, the plurality of connecting springs comprising at least two large springs of a first length and at least two short springs of a second length, the first length greater than the second length, the springs and masses having relational and mechanical characteristics to facilitate elastic wave cloaking in the totality of the lattice. The lattice as a whole has metamaterial properties resulting from the positional relationship and mechanical properties of masses and connecting springs of the unit cells such that the lattice at least partially cloaks an object or material portioned within the void from elastic waves. |
| FILED | Thursday, February 24, 2022 |
| APPL NO | 17/679854 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 50/00 (20141201) B33Y 80/00 (20141201) Springs; Shock-absorbers; Means for Damping Vibration F16F 3/02 (20130101) Original (OR) Class F16F 2228/066 (20130101) F16F 2234/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220412710 | Timler et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Science Applications International Corporation (Reston, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John P. Timler (River Ridge, Louisiana); David M. Morris (Bloomington, Indiana) |
| ABSTRACT | Countermeasure simulating structures may include (a) a base and (b) one or more separated combustible tracks fixed to the base's surface. The combustible tracks may include thermite and/or other combustible material. The combustible tracks may be shaped to simulate countermeasure flares deployed by a vehicle (e.g., a jet). The countermeasure simulating structure may be incorporated into a countermeasure simulating system that includes (a) an infrared and/or optical sensing system (e.g., like those included in missiles) and (b) a simulator mount holding the countermeasure simulating structure. Countermeasures may be tested in such systems by: (a) arranging an infrared and/or optical sensing system to receive infrared energy and/or visible light emitted by the countermeasure simulating structure; (b) igniting the combustible material of the combustible track such that combustion of the combustible material moves along the combustible track; and (c) determining whether the infrared and/or optical sensing system tracks infrared energy and/or visible emitted by the combustion. |
| FILED | Tuesday, June 29, 2021 |
| APPL NO | 17/362176 |
| CURRENT CPC | Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 99/00 (20130101) Original (OR) Class Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 99/002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220412914 | Hagen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University Of Cincinnati (Cincinnati, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joshua A. Hagen (Cincinnati, Ohio); Jason C. Heikenfeld (Cincinnati, Ohio); Ian Papautsky (Willowbrook, Illinois); Linlin Hou (Portland, Oregon); Rajesh Naik (Centerville, Ohio); Nancy Kelley-Loughnan (Cincinnati, Ohio); Morley O. Stone (Columbus, Ohio); John Busbee (Washington Township, Ohio); Xiao Wang (Waltham, Massachusetts) |
| ABSTRACT | Biological chemicals, potentially found in blood are measured by collecting sweat and determining the concentration or meaning of the selected chemical in sweat. The sweat can be collected using a time based, interval collector and analyzed using an external device. It can also be collected on a one time basis, using a flexible, chemical capacitor, or on a continuous basis using a chemical, field effect transducer. |
| FILED | Tuesday, August 30, 2022 |
| APPL NO | 17/823286 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0002 (20130101) A61B 5/681 (20130101) A61B 5/1477 (20130101) A61B 5/14517 (20130101) A61B 5/14532 (20130101) A61B 5/14546 (20130101) A61B 10/0064 (20130101) A61B 10/0096 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/5023 (20130101) B01L 2200/0621 (20130101) B01L 2300/022 (20130101) B01L 2300/023 (20130101) B01L 2300/069 (20130101) B01L 2300/0645 (20130101) B01L 2300/0803 (20130101) B01L 2300/0864 (20130101) B01L 2400/086 (20130101) B01L 2400/0406 (20130101) B01L 2400/0677 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/3273 (20130101) Original (OR) Class G01N 27/4145 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220412926 | GIURGIUTIU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTH CAROLINA (Columbia, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | VICTOR GIURGIUTIU (COLUMBIA, South Carolina); HANFEI MEI (COLUMBIA, South Carolina); JOSEPH GARRETT (CHARLESTON, South Carolina); KIMBERLY CARDILLO (DENVER, Colorado) |
| ABSTRACT | Method and apparatus estimate the length of a fatigue crack in sheet metal structures from individual acoustic emission (AE) signals without recourse to the AE signal history or AE signal amplitude. AE energy generated at one crack tip travels to the other tip and establishes a standing wave pattern that has a characteristic dominant frequency which depends on the crack length. Therefore, crack length information can be recovered from the analysis of the standing wave frequency present in the high-frequency AE signals. We found that the AE signals predicted through numerical simulation have embedded in the high-frequency information that can be related directly to crack size. This information is manifested as peaks in the frequency spectrum that shift as crack length changes. The predictive AE models were tuned against experimentally observed AE signals and a methodology for predicting crack length from AE signals was established. This methodology was utilized to develop machine learning algorithms for predicting crack length directly from individual AE signals. Specific artificial intelligence methodology presently disclosed can estimate in real-time the crack length information from the high-frequency AE waveforms during fatigue crack growth. |
| FILED | Tuesday, March 08, 2022 |
| APPL NO | 17/689557 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/12 (20130101) G01N 29/14 (20130101) G01N 29/4472 (20130101) G01N 29/4481 (20130101) Original (OR) Class G01N 2291/0289 (20130101) Electric Digital Data Processing G06F 30/23 (20200101) G06F 30/27 (20200101) Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/084 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220413007 | GRINOLDS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Michael S. GRINOLDS (Cambridge, Massachusetts); Sungkun HONG (Cambridge, Massachusetts); Patrick MALETINSKY (Cambridge, Massachusetts); Amir YACOBY (Cambridge, Massachusetts) |
| ABSTRACT | A sensing probe may be formed of a diamond material comprising one or more spin defects that are configured to emit fluorescent light and are located no more than 50 nm from a sensing surface of the sensing probe. The sensing probe may include an optical outcoupling structure formed by the diamond material and configured to optically guide the fluorescent light toward an output end of the optical outcoupling structure. An optical detector may detect the fluorescent light that is emitted from the spin defects and that exits through the output end of the optical outcoupling structure after being optically guided therethrough. A mounting system may hold the sensing probe and control a distance between the sensing surface of the sensing probe and a surface of a sample while permitting relative motion between the sensing surface and the sample surface. |
| FILED | Friday, February 18, 2022 |
| APPL NO | 17/675156 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/645 (20130101) G01N 24/10 (20130101) Scanning-probe Techniques or Apparatus; Applications of Scanning-probe Techniques, e.g Scanning Probe Microscopy [SPM] G01Q 30/025 (20130101) G01Q 60/38 (20130101) G01Q 60/54 (20130101) G01Q 70/14 (20130101) Original (OR) Class Measuring Electric Variables; Measuring Magnetic Variables G01R 33/022 (20130101) G01R 33/032 (20130101) G01R 33/60 (20130101) G01R 33/1284 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220413118 | Starr et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SensorMetrix (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anthony F. Starr (San Diego, California); Tatiana N. Starr (San Diego, California); Darren R.F. Schurig (Huntington Beach, California) |
| ABSTRACT | A ballistic detection system includes a radar system; electromagnetic radiation detection equipment positioned on only a single side of a target volume; and a ballistics analysis computer configured to obtain image data captured by first and second cameras in accordance with timing specified by radar data, determine points in three-dimensional space, which correspond to image artifacts of a projectile, using intrinsic and extrinsic parameters of the first and second cameras, define a trajectory of the projectile within a target volume using the points in three-dimensional space, and find a point of intersection of the trajectory of the projectile with an object associated with the target volume. |
| FILED | Tuesday, April 05, 2022 |
| APPL NO | 17/714084 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 13/58 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 7/70 (20170101) G06T 2207/30241 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220413119 | Starr et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SensorMetrix (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anthony F. Starr (San Diego, California); Tatiana N. Starr (San Diego, California); Darren R.F. Schurig (Huntington Beach, California) |
| ABSTRACT | A ballistic detection system includes a first camera; a second camera; a solar block device associated with at least one camera of the first and second cameras, wherein the solar block device is configured and arranged to block a solar disc in a field of view of the at least one camera; and a ballistics analysis computer configured to obtain image data captured by the first and second cameras, determine at least two points in three-dimensional space, which correspond to image artifacts of a projectile, using intrinsic and extrinsic parameters of the first and second cameras, define a trajectory of the projectile within a target volume using the at least two points in three-dimensional space, and find a point of intersection of the trajectory of the projectile with an object associated with the target volume. |
| FILED | Tuesday, April 05, 2022 |
| APPL NO | 17/714088 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/4808 (20130101) G01S 13/58 (20130101) Original (OR) Class G01S 17/06 (20130101) Image Data Processing or Generation, in General G06T 7/70 (20170101) G06T 2207/30241 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220413216 | Hosseini et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | Intel Corporation (Santa Clara, California) |
| INVENTOR(S) | Kaveh Hosseini (San Jose, California); Conor O'Keeffe (Santa Clara, California) |
| ABSTRACT | An integrated circuit (IC) package comprising an optical die comprising a configurable optical switch. The configurable optical switch comprises an optical switch operably coupled to one or more optical transceivers. An optical connector comprises at least one exo-package optical port. The at least one exo-package optical port is operably coupled to the configurable optical switch. The configurable optical switch is to pass an optical signal on the at least one of the one or more exo-package ports to at least one of the one or more optical transceivers, and an IC die comprising electronic circuitry is operably coupled to the one or more optical transceivers. |
| FILED | Friday, June 25, 2021 |
| APPL NO | 17/359374 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/13 (20130101) G02B 6/12021 (20130101) Original (OR) Class Transmission H04B 10/40 (20130101) H04B 10/803 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220413855 | Pawlowski et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Pawlowski (Beaverton, Oregon); Sriram Aananthakrishnan (Portland, Oregon); Jason Howard (Portland, Oregon); Joshua Fryman (Corvallis, Oregon) |
| ABSTRACT | Techniques for operating on an indirect memory access instruction, where the instruction accesses a memory location via at least one indirect address. A pipeline processes the instruction and a memory operation engine generates a first access to the at least one indirect address and a second access to a target address determined by the at least one indirect address. A cache memory used with the pipeline and the memory operation engine caches pointers. In response to a cache hit when executing the indirect memory access instruction, operations dereference a pointer to obtain the at least one indirect address, not set a cache bit, and return data for the instruction without storing the data in the cache memory; and in response to a cache miss, operations set the cache bit, obtain, and store a cache line for a missed pointer, and return data without storing the data in the cache memory. |
| FILED | Friday, June 25, 2021 |
| APPL NO | 17/359305 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/3861 (20130101) G06F 9/3867 (20130101) G06F 9/30043 (20130101) G06F 9/30047 (20130101) Original (OR) Class G06F 12/0875 (20130101) G06F 2212/1021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220414004 | Brewer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tony Brewer (Plano, Texas); Dean E. Walker (Allen, Texas); Chris Baronne (Allen, Texas) |
| ABSTRACT | Devices and techniques for memory access bounds checking for a programmable atomic operator are described herein. A processor can execute a programmable atomic operator with a base memory address. The processor can obtain a memory interleave size indicator corresponding to the programmable atomic operator and calculate a contiguous memory address range from the base memory address and the memory interleave size. The processor can then detect that a memory request from the programmable atomic operator is outside the contiguous memory address range and deny the memory request when it is outside of the contiguous memory address range and allow the memory request otherwise. |
| FILED | Thursday, June 30, 2022 |
| APPL NO | 17/854770 |
| CURRENT CPC | Electric Digital Data Processing G06F 12/0223 (20130101) G06F 12/0607 (20130101) Original (OR) Class G06F 12/0844 (20130101) G06F 2212/1012 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220414038 | PAWLOWSKI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ROBERT PAWLOWSKI (Beaverton, Oregon); BHARADWAJ KRISHNAMURTHY (HILLSBORO, Oregon); SHRUTI SHARMA (HILLSBORO, Oregon); BYOUNGCHAN OH (Hillsboro, Oregon); JING FANG (Santa Clara, California); DANIEL KLOWDEN (Portland, Oregon); JASON HOWARD (Portland, Oregon); JOSHUA FRYMAN (Corvallis, Oregon) |
| ABSTRACT | Systems, methods, and apparatuses for direct memory access instruction set architecture support for flexible dense compute using a reconfigurable spatial array are described. In one embodiment, a processor includes a first type of hardware processor core that includes a two-dimensional grid of compute circuits, a memory, and a direct memory access circuit coupled to the memory and the two-dimensional grid of compute circuits; and a second different type of hardware processor core that includes a decoder circuit to decode a single instruction into a decoded single instruction, the single instruction including a first field to identify a base address of two-dimensional data in the memory, a second field to identify a number of elements in each one-dimensional array of the two-dimensional data, a third field to identify a number of one-dimensional arrays of the two-dimensional data, a fourth field to identify an operation to be performed by the two-dimensional grid of compute circuits, and a fifth field to indicate the direct memory access circuit is to move the two-dimensional data indicated by the first field, the second field, and the third field into the two-dimensional grid of compute circuits and the two-dimensional grid of compute circuits is to perform the operation on the two-dimensional data according to the fourth field, and an execution circuit to execute the decoded single instruction according to the fields |
| FILED | Friday, June 25, 2021 |
| APPL NO | 17/358832 |
| CURRENT CPC | Electric Digital Data Processing G06F 13/28 (20130101) Original (OR) Class G06F 2213/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220414108 | Strelzoff et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America as Represented by the Secretary of The Army (Alexandria, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew P. Strelzoff (Vicksburg, Mississippi); Ashley N. Abraham (Vicksburg, Mississippi); Althea C. Henslee (Vicksburg, Mississippi); Haley R. Dozier (Vicksburg, Mississippi); Mark A. Chappell (Vicksburg, Mississippi) |
| ABSTRACT | An example method of performing searches by comparing regions includes identifying a search point contained in geo-located data. The search point is nearest in distance to a query location. A search region associated with the search point is determined. The search region includes neighbor points contained in the geo-located data that are nearest the search point. Centroids corresponding respectively to the plurality of neighbor points of the search region are determined. The centroids of the search region are compared to other centroids corresponding to other regions of the geo-located data. The number of other centroids that match with the plurality of centroids are counted, and the counts are placed in descending order, to list the other regions having the highest similarity first. An ordered list of the other regions is generated based on their respective similarities to the query region. |
| FILED | Tuesday, June 29, 2021 |
| APPL NO | 17/361776 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/29 (20190101) G06F 16/9537 (20190101) G06F 16/24578 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220414276 | Ginsberg |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America as Represented by The Secretary of The Army (Alexandria, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark D. Ginsberg (Champaign, Illinois) |
| ABSTRACT | In one embodiment, a method includes: accepting input data for a design including arrangement of spaces of a structure, operating parameters of a ventilation system, and locations and relative positions of an uninfected individual and one or more infected individuals in the structure with respect to air flowing in the structure and influenced by the ventilation system; calculating an inverse protection factor for the structure using a lumped element model, the inverse protection factor being an inverse of a protection factor which is a ratio of contaminant which the one or more infected individuals exhale in the structure and contaminant which the uninfected individual inhales in the structure; comparing the calculated inverse protection factor to a preset criterion; and if the calculated inverse protection factor fails to meet the preset criterion, changing the design, and repeating the calculating, comparing, and changing until the calculated inverse protection factor meets the preset criterion. |
| FILED | Wednesday, June 16, 2021 |
| APPL NO | 17/349544 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/12 (20200101) Original (OR) Class G06F 30/20 (20200101) G06F 2111/10 (20200101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/101 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 40/20 (20180101) G16H 50/80 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220414305 | Barker |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Synopsys, Inc. (Mountain View, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aaron John Barker (Broomfield, Colorado) |
| ABSTRACT | Samples of metrics measured on physical devices are selected from a larger number of samples. The samples are selected based on the distributions of the measured metrics. A set of model instances are constructed that correspond to the selected set of samples. The model instances have parameters, which are set such that simulation of the model instances using the parameters predicts metrics that match the measured metrics from the set of samples. The principal components of the variances of the parameters is calculated. Non-linear models are fitted to the parameter variances as a function of the principal components. Statistical variations of the principal components are applied to the non-linear models to yield statistical variations in the parameters; and these are applied to simulations of model instances to yield statistical variations of a property of the device being simulated. |
| FILED | Tuesday, June 29, 2021 |
| APPL NO | 17/362417 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/3308 (20200101) Original (OR) Class G06F 2111/10 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220414466 | Ding |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jie Ding (Plymouth, Minnesota) |
| ABSTRACT | Techniques are disclosed for assisted learning with enhanced privacy. A method comprises: sending first statistical information from a first agent to a second agent in an architecture having at least two agents, wherein a first set of sample weights correspond to training the first machine learning model, wherein the first statistical information comprises the second set of sample weights determined from a first model weight; receiving, from the second agent, second statistical information comprising the second model weight and updated first set of sample weights or, from a third agent of the architecture, third statistical information comprising a third model weight and a next iteration of the first set of sample weights; and updating the first machine learning model using the second statistical information or the third statistical information. |
| FILED | Thursday, June 09, 2022 |
| APPL NO | 17/806200 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6256 (20130101) G06K 9/6265 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Original (OR) Class G06N 3/0454 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220414476 | LIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SRI International (Menlo Park, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiao LIN (Union City, California); Meng YE (Lawrenceville, New Jersey); Yunye GONG (West Windsor, New Jersey); Giedrius T. BURACHAS (Doylestown, Pennsylvania); Ajay DIVAKARAN (Monmouth Junction, New Jersey); Yi YAO (Princeton, New Jersey); Nikoletta BASIOU (Palo Alto, California) |
| ABSTRACT | A method, apparatus and system for adapting a pre-trained network for application to a different dataset includes arranging at least two different types of active adaptation modules in a pipeline configuration, wherein an output of a previous active adaptation module produces an input for a next active adaptation module in the pipeline in the form of adapted network data until a last active adaptation module, and wherein each of the at least two different types of adaptation modules can be switched on or off, determining at least one respective hyperparameter for each of the at least two different types of active adaptation modules, and applying the at least one respective determined hyperparameter to each of the at least two different types of active adaptation modules for processing received data from the pretrained network to determine an adapted network. |
| FILED | Monday, June 20, 2022 |
| APPL NO | 17/844701 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6228 (20130101) Computer Systems Based on Specific Computational Models G06N 3/088 (20130101) Original (OR) Class G06N 3/0472 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220415440 | BO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chunkun BO (Charlottesville, Virginia); Kevin SKADRON (Charlottesville, Virginia); Elaheh SADREDINI (Charlottesville, Virginia); Vinh DANG (Charlottesville, Virginia) |
| ABSTRACT | A method of operating a finite state machine circuit can be provided by determining if a target sequence of characters included in a string of reference characters occurs within a specified difference distance using states indicated by the finite state machine circuit to indicate a number of character mis-matches between the target sequence of characters and a respective sequence of characters within the string of reference characters. |
| FILED | Thursday, July 14, 2022 |
| APPL NO | 17/864710 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/90344 (20190101) Computer Systems Based on Specific Computational Models G06N 5/047 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 30/00 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220416498 | Redding et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brandon F. Redding (University Park, Maryland); Joseph Brady Murray (Ellicott City, Maryland) |
| ABSTRACT | Optical frequency combs are used for a wide range of applications, some of which require precise control of the amplitude and phase of individual comb teeth. A technique is provided for tooth-level optical frequency comb control. A frequency comb may include a plurality of comb teeth that are separated from one another by a comb frequency spacing. This technique includes generating a train of control pulses, each of the control pulses being frequency-locked to a corresponding tooth of an optical frequency comb to be controlled. The tooth-level control of the frequency comb is enabled via stimulated Brillouin scattering using the train of control pulses. |
| FILED | Thursday, June 16, 2022 |
| APPL NO | 17/807168 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/353 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/1086 (20130101) H01S 3/1106 (20130101) H01S 3/1305 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220417041 | Howard et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RAYTHEON COMPANY (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jennifer E. Howard (Prosper, Texas); Colby K. Hoffman (Fairview, Texas); Edward Escandon (McKinney, Texas); Albert D. Marzullo (Plano, Texas); Ross MacKinnon (McKinney, Texas); Maegen A. Forrer (Farmersville, Texas) |
| ABSTRACT | A multi-die device a first die containing a plurality of first die signal path elements configured to propagate a stimulus signal and a second die containing a plurality of second die signal path elements configured to propagate the stimulus signal. The multi-die device further includes an interposer configured to establish signal communication between the first die and the second die so as to deliver the stimulus signal from the plurality of first die signal path elements to the plurality of second die signal path elements to generate a propagation delay. The propagation delay is used to generate a single unified PUF response that is indicative of the authenticity of the multi-die device. |
| FILED | Thursday, June 24, 2021 |
| APPL NO | 17/357067 |
| CURRENT CPC | Ciphering or Deciphering Apparatus for Cryptographic or Other Purposes Involving the Need for Secrecy G09C 1/10 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0866 (20130101) H04L 9/3278 (20130101) Original (OR) Class H04L 2209/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220417043 | Cambou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of Northern Arizona University (Flagstaff, Arizona); Government of the United States of America, as represented by the Secretary of the Air Force (Rome, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bertrand F. Cambou (Flagstaff, Arizona); Sareh Assiri (Flagstaff, Arizona); Christopher Robert Philabaum (Flagstaff, Arizona); H. Shelton Jacinto (Rome, New York) |
| ABSTRACT | Systems and methods for providing authentication and secure cryptographic communication between a client and server are described. The client includes an addressable array of PUF devices. The client receives or generates a set of instructions usable to determine a range of PUF addresses. The client measures the PUF addresses and generates a first set of responses. The responses are used to encrypt a session key, which is stored, along with the instructions and a hash of the responses, at the client. Later, the client may recover the session key by using the instructions to measure the PUF again, resulting in a second set of responses. Using a response-based cryptography search engine, the client may then iteratively modify and hash the second set of responses until a response set is uncovered that matches the first response set. This modified response set may then be used to uncover the session key. |
| FILED | Saturday, June 25, 2022 |
| APPL NO | 17/849623 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/3236 (20130101) H04L 9/3278 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220418170 | Duffy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason C. Duffy (Granby, Connecticut); Kenneth J. Trotman (Granby, Connecticut) |
| ABSTRACT | A chassis includes top rails extending along a top side of the chassis, bottom rails extending along a bottom side of the chassis, a fluid inlet connected to the chassis that is configured to receive a thermal transfer fluid, and a fluid outlet connected to the chassis that is configured to discharge the thermal transfer fluid. The chassis further includes a thermal transfer fluid path extending between and fluidly coupled to the fluid inlet and the fluid outlet, wherein the thermal transfer fluid is configured to flow through the thermal transfer fluid path, and wherein the thermal transfer fluid path extends in a serpentine pattern through at least one of the top rails and through at least one of the bottom rails. |
| FILED | Monday, June 28, 2021 |
| APPL NO | 17/360839 |
| CURRENT CPC | Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 37/34 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 7/20272 (20130101) H05K 7/20872 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20220408731 | Shah et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Donald Danforth Plant Science Center (ST. LOUIS, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dilip M. Shah (St. Louis, Missouri); Meenakshi Tetorya (St. Louis, Missouri) |
| ABSTRACT | Antimicrobial defensin peptide variants comprising modified C-terminal fragments of a defensin and nucleic acids encoding the same are disclosed. Compositions comprising the defensin variant peptides and methods of their use to control microbial infections of plants and vertebrate subjects as well as contamination of feedstuffs and foodstuffs are also disclosed. |
| FILED | Thursday, June 16, 2022 |
| APPL NO | 17/807209 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 63/50 (20200101) Original (OR) Class Biocidal, Pest Repellant, Pest Attractant or Plant Growth Regulatory Activity of Chemical Compounds or Preparations A01P 3/00 (20210801) Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/4723 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220409404 | Yang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhi Yang (Minneapolis, Minnesota); Anh Tuan Nguyen (Minneapolis, Minnesota); Diu Khue Luu (Minneapolis, Minnesota) |
| ABSTRACT | A neurostimulator incorporating a novel chip design that uses the principle of redundant signal crossfiring to overcome electronic component mismatch error in general and transistor mismatch error in particular, to yield superior quality neurostimulation signal generation, useful in enhancing the bidirectional human-machine interface in prosthesis operation for the restoration of somatosensation for an amputee. |
| FILED | Friday, June 24, 2022 |
| APPL NO | 17/849534 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/72 (20130101) Original (OR) Class A61F 2/583 (20130101) A61F 2002/5061 (20130101) Systems for Regulating Electric or Magnetic Variables G05F 3/262 (20130101) Coding; Decoding; Code Conversion in General H03M 1/66 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220409758 | El-Ghazaly et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Little Rock, Arkansas) |
| ASSIGNEE(S) | BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Little Rock, Arkansas) |
| INVENTOR(S) | Samir El-Ghazaly (Fayetteville, Arkansas); Amirreza Ghadimi Avval (Fayetteville, Arkansas); Sara Ghayouraneh (Fayetteville, Arkansas); Saleh Alfawaz (Fayetteville, Arkansas); Ibrahim Alquaydheb (Fayetteville, Arkansas) |
| ABSTRACT | A microwave-plasma disinfector (Origreen) with a microwave source with multi-feed points and variable output power. It also has a low-temperature atmospheric-pressure plasma source. This versatile microwave-plasma disinfector has the ability to decontaminate heat-sensitive materials by subjecting them to a microwave-assisted plasma with controlled microwave power. This dual-action, at suitable non-destructive microwave and plasma doses, sterilizes the equipment at a lower temperature with higher effectiveness than either plasma or microwaves alone |
| FILED | Wednesday, June 29, 2022 |
| APPL NO | 17/853804 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 2/12 (20130101) A61L 2/14 (20130101) Original (OR) Class A61L 2/26 (20130101) A61L 2202/11 (20130101) A61L 2202/14 (20130101) Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 1/01 (20210501) H05H 2245/36 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411344 | Voigt et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Christopher A. Voigt (Belmont, Massachusetts); Min-Hyung Ryu (Cambridge, Massachusetts); Mi Ryoung Song (Boston, Massachusetts) |
| ABSTRACT | The invention relates to methods for promoting fixed nitrogen from atmospheric nitrogen, and related products. Endophytic bacteria having an exogenous nif cluster promote fixed nitrogen for cereal plants. |
| FILED | Friday, August 26, 2022 |
| APPL NO | 17/822740 |
| CURRENT CPC | Organic Fertilisers Not Covered by Subclasses C05B, C05C, e.g Fertilisers From Waste or Refuse C05F 11/08 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/52 (20130101) C12N 15/70 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411359 | Bara et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of The University of Alabama (Tuscaloosa, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason Edward Bara (Tuscaloosa, Alabama); Shuai Qian (Northport, Alabama) |
| ABSTRACT | Disclosed are compounds and methods for solubilizing polymers and oligomers. The compounds have the formula: wherein R1, Q1 and Q2 are defined herein. |
| FILED | Wednesday, March 30, 2022 |
| APPL NO | 17/708589 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 43/135 (20130101) C07C 49/167 (20130101) C07C 49/175 (20130101) Original (OR) Class Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 11/24 (20130101) C08J 11/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411373 | Cooks et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Graham Cooks (West Lafayette, Indiana); Christopher Pulliam (West Lafayette, Indiana); Ryan M. Bain (West Lafayette, Indiana) |
| ABSTRACT | The invention generally relates to conducting reactions in Leidenfrost-levitated droplets. |
| FILED | Tuesday, August 23, 2022 |
| APPL NO | 17/893399 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 45/72 (20130101) Heterocyclic Compounds C07D 209/40 (20130101) C07D 213/04 (20130101) Original (OR) Class Steroids C07J 41/0005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411447 | Waterman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Vermont and State Agricultural College (Burlington, Vermont) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rory Waterman (Burlington, Vermont); Brandon Ackley (Beavercreek, Ohio) |
| ABSTRACT | Methods of preparing primary phosphine products using one or more precursor cyclophosphanes, hydrogen, and one or more Lewis acid catalysts. In some embodiments, a cyclophosphane precursor and at least one Lewis acid are dissolved in a solvent to provide a solution. The solution is treated with hydrogen, and optionally heated, to cause a reaction that produces a primary phosphine © product. The primary phosphine product may be isolated from the Lewis acid(s) and optionally purified. In some embodiments, a method may include synthesizing the cyclophosphane precursor prior to mixing the cyclophosphane precursor and the Lewis acid(s). |
| FILED | Thursday, January 07, 2021 |
| APPL NO | 17/787650 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/5072 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411574 | Lai et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Board of Trustees of the Leland Stanford Junior University (A/K/A Stanford University) (Stanford, California); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Holden Wan Hong Lai (Stanford, California); Jun Myun Ahn (Stanford, California); Yan Xia (Stanford, California); Zachary P. Smith (Cambridge, Massachusetts); Francesco M. Benedetti (Cambridge, Massachusetts) |
| ABSTRACT | Disclosed herein are ladder polymers comprising fused aromatic and non-aromatic rings. Also disclosed are the manufacture and use of these ladder polymers, e.g., in separation membranes, such as membrane for gas separation. |
| FILED | Friday, October 23, 2020 |
| APPL NO | 17/771434 |
| CURRENT CPC | Separation B01D 69/02 (20130101) B01D 71/76 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 61/02 (20130101) C08G 61/122 (20130101) Original (OR) Class C08G 2261/344 (20130101) C08G 2261/1336 (20130101) C08G 2261/3142 (20130101) C08G 2261/3242 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411596 | Wiesner et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York); YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ulrich B. Wiesner (Ithaca, New York); Rachel M. Dorin (San Francisco, California); Joerg Werner (San Francisco, California); William A. Phillip (New Haven, Connecticut) |
| ABSTRACT | A method for forming an isoporous graded film comprising multiblock copolymers and isoporous graded films. The films have a surface layer and a bulk layer. The surface layer can have at least 1×1014 pores/m2 and a pore size distribution (dmax/dmin)) of less than 3. The bulk layer has an asymmetric structure. The films can be used in filtration applications. |
| FILED | Monday, August 29, 2022 |
| APPL NO | 17/897751 |
| CURRENT CPC | Separation B01D 67/0009 (20130101) B01D 69/02 (20130101) B01D 69/12 (20130101) B01D 71/022 (20130101) B01D 71/26 (20130101) B01D 71/28 (20130101) B01D 71/44 (20130101) B01D 71/80 (20130101) B01D 2325/04 (20130101) B01D 2325/021 (20130101) B01D 2325/023 (20130101) B01D 2325/48 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 297/04 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/18 (20130101) Original (OR) Class C08J 2353/00 (20130101) Compositions of Macromolecular Compounds C08L 53/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411664 | Sitti et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Metin Sitti (Pittsburgh, Pennsylvania); Michael Murphy (Pittsburgh, Pennsylvania); Burak Aksak (Pittsburgh, Pennsylvania) |
| ABSTRACT | Dry adhesives and methods for forming dry adhesives. A method of forming a dry adhesive structure on a backing material, comprises: forming a template backing layer of energy sensitive material on the backing material; forming a template layer of energy sensitive material on the template backing layer; exposing the template layer to a predetermined pattern of energy; removing a portion of the template layer related to the predetermined pattern of energy, and leaving a template structure formed from energy sensitive material and connected to the substrate via the template backing layer. |
| FILED | Thursday, August 25, 2022 |
| APPL NO | 17/895334 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 33/3857 (20130101) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2031/757 (20130101) Processes or Apparatus Specially Adapted for the Manufacture or Treatment of Microstructural Devices or Systems B81C 1/00031 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) B82Y 40/00 (20130101) Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 7/00 (20130101) Original (OR) Class C09J 2301/31 (20200801) C09J 2301/416 (20200801) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/0002 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/24479 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411757 | Palecek et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sean Palecek (Verona, Wisconsin); Martha Floy (Madison, Wisconsin) |
| ABSTRACT | The disclosure generally relates to methods for generating cardiac fibroblast cells from epicardial cardiac progenitor cells, populations of cardiac fibroblast cells and uses thereof. |
| FILED | Thursday, June 09, 2022 |
| APPL NO | 17/836693 |
| CURRENT CPC | Peptides C07K 14/503 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0656 (20130101) Original (OR) Class C12N 5/0657 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5044 (20130101) G01N 33/48728 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411790 | Zou et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Roger Zou (Baltimore, Maryland); Yang Liu (Baltimore, Maryland); Taekjip Ha (Baltimore, Maryland) |
| ABSTRACT | A gene-editing system includes an engineered photocleavable guide RNA to endow Cas9 nuclease and base editing activities with a built-in mechanism for fast, light-mediated deactivation. In methods of use, the system retains high editing efficiency, natively improves specificity, offers precise spatial and temporal control, improves base editing purity through early deactivation. |
| FILED | Sunday, October 25, 2020 |
| APPL NO | 17/770531 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) Original (OR) Class C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411806 | Lynch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Lynch (Durham, North Carolina); Romel Menacho Melgar (Durham, North Carolina); Zhixia Ye (Raleigh, North Carolina); Eirik A. Moreb (Durham, North Carolina) |
| ABSTRACT | Improved production of recombinant proteins in E. coli, reliant on tightly controlled autoinduction, triggered by phosphate depletion in stationary phase. The process also provides an optimized autoinduction media, enabling routine batch production at various culture volumes where cells densities routinely reach ˜5-7 g cell dry weight per liter and offer protein titers above 2 g/L. The methodology has been validated with a set of diverse heterologous proteins and is of general use for the facile optimization of routine protein expression from high throughput screens to fed-batch fermentation. |
| FILED | Friday, October 23, 2020 |
| APPL NO | 17/755158 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 15/70 (20130101) C12N 15/635 (20130101) Original (OR) Class C12N 2500/14 (20130101) C12N 2500/16 (20130101) C12N 2500/24 (20130101) C12N 2500/42 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411809 | Lippman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cold Spring Harbor Laboratory (Cold Spring Harbor, New York) |
| ASSIGNEE(S) | Cold Spring Harbor Laboratory (Cold Spring Harbor, New York) |
| INVENTOR(S) | Zachary Lippman (North Bellmore, New York); Choon-Tak Kwon (Cold Spring Harber, New York) |
| ABSTRACT | Aspects of the disclosure relate to plants containing one or more of a mutant sler (Solyc08g061560) gene or a homolog thereof, a mutant sp5g (Solyc05g053850) gene or a homolog thereof and a mutant sp (Solyc06g074350) gene or a homolog thereof, as well as methods of producing such plants. In some aspects, such plants have one or more improved traits, such as modified stem length and modified time for flowering and fruit production. |
| FILED | Friday, November 20, 2020 |
| APPL NO | 17/779987 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8213 (20130101) Original (OR) Class C12N 15/8262 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411885 | CHANDA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (ORLANDO, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | DEBASHIS CHANDA (OVIEDO, Florida); ABRAHAM VAZQUEZ-GUARDADO (EVANSTON, Illinois) |
| ABSTRACT | A method is for detecting a biomarker within a sample of blood. The method may include processing the sample of blood with a microfluidic blood plasma separator and a plasmonic array biosensor, and flowing the sample of blood over a sensing surface of the plasmonic array biosensor. The sensing surface of the plasmonic array biosensor may have an ssDNA aptamer against the biomarker. The method may further include binding the biomarker in the sample of blood to the ssDNA aptamer of the plasmonic array biosensor, and detecting the biomarker in the sample of blood based upon LSPR altering a reflected optical signal from the plasmonic array biosensor. |
| FILED | Thursday, April 28, 2022 |
| APPL NO | 17/661141 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/701 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220412307 | Leonardi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stefano Leonardi (Richardson, Texas); Mario Rotea (Allen, Texas); Umberto Ciri (Dallas, Texas); Federico Bernardoni (Dallas, Texas) |
| ABSTRACT | Enabling control of wind turbines is provided. The method comprises receiving power production signals from wind turbines comprising a wind farm and estimating wake travel times from upstream wind turbines to downstream turbines. Correlations of the power production signals are calculated among all pairs of wind turbines in the wind farm. Wind turbines with a power production correlation above a specified threshold at an expected time are considered to have wake interaction. A probability density function of northing directions is calculated for the wind turbine pairs with wake interaction. A determination is made whether the probability density function has a dominant direction. Responsive to the probability density function having a dominant direction, the wind turbine pairs with wake interaction are identified as turbine clusters. A control strategy is applied to each turbine cluster as an operational unit to optimize power production of the wind farm. |
| FILED | Friday, June 24, 2022 |
| APPL NO | 17/808700 |
| CURRENT CPC | Wind Motors F03D 7/028 (20130101) Original (OR) Class F03D 7/048 (20130101) Indexing Scheme Relating to Wind, Spring, Weight, Inertia or Like Motors, to Machines or Engines for Liquids Covered by Subclasses F03B, F03D and F03G F05B 2270/321 (20130101) F05B 2270/1033 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/381 (20130101) H02J 2300/28 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220412800 | BRUECK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven R.J. BRUECK (Albuquerque, New Mexico); Payman ZARKESH-HA (Albuquerque, New Mexico); Alexander NEUMANN (Albuquerque, New Mexico) |
| ABSTRACT | A spectral sensor and a method for forming the spectral sensor is disclosed. The spectral sensor includes a planar waveguide on a substrate; a restriction mechanism that restricts a range of angles of incidence of light impinging onto the chirped input coupling grating; the chirped input grating formed to couple incident light into the planar waveguide, wherein the chirped input coupling grating comprises a first transverse chirp to provide a spectrally selective coupling of incident light Into the planar waveguide; a propagation region to filter out light that is not coupled into the planar waveguide; a detector array arranged on the opposite side of the propagation region from the chirped input coupling S grating to receive light coupled out of the planar waveguide and produce output signals representative of the light; and an electrical circuit to readout output signals from the detector array. |
| FILED | Thursday, November 19, 2020 |
| APPL NO | 17/777805 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/04 (20130101) G01J 3/24 (20130101) Original (OR) Class G01J 3/0256 (20130101) G01J 3/1895 (20130101) Optical Elements, Systems, or Apparatus G02B 6/42 (20130101) G02B 6/4215 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220412804 | KAR et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Swastik KAR (Belmont, Massachusetts); Davoud HEJAZI (Malden, Massachusetts); Sarah OSTADABBAS (Boston, Massachusetts) |
| ABSTRACT | Devices and methods of the present technology utilize wavelength-dependent transmittance of 2D materials to identify the wavelength of an electromagnetic radiation. A wide range of 2D materials can be used, making possible the use of the technology over a large portion of the electromagnetic spectrum, from gamma rays to the far infrared. When combined with appropriate algorithms and artificial intelligence, the technology can identify the wavelength of one or more monochromatic sources, or can identify color through the use of a training set. When applied in an array format, the technology can provide color imaging or spectral imaging using different regions of the electromagnetic spectrum. |
| FILED | Monday, November 16, 2020 |
| APPL NO | 17/777091 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/462 (20130101) Original (OR) Class G01J 3/513 (20130101) G01J 2003/1213 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220412949 | Khalil et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Cincinnati (Cincinnati, Ohio) |
| ASSIGNEE(S) | University of Cincinnati (Cincinnati, Ohio) |
| INVENTOR(S) | Essraa Abdelwahab Hussein Khalil (Cincinnati, Ohio); Ryan White (Cincinnati, Ohio) |
| ABSTRACT | A composition having one or more nanoneedles is provided, where each nanoneedle has a silver tip and one or more of the silver tips comprise an AgCl layer. In one approach, one or more of the silver tips further include a layer of thiol-polyethylene glycol. A method of resistive pulse detection involving a protein pore is also provided. The method involves reconstituting one or more protein pores in a lipid membrane formed on the tip of a nanoneedle, then applying a potential across the membrane and detecting resistive pulses. |
| FILED | Tuesday, June 28, 2022 |
| APPL NO | 17/852315 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) G01N 33/48721 (20130101) Original (OR) Class G01N 33/54373 (20130101) G01N 2800/2821 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220412974 | TABIB-AZAR |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Utah Research Foundation (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | MASSOOD TABIB-AZAR (Salt Lake City, Utah) |
| ABSTRACT | Technologies are described for detecting a pathogen. An example system can include a sensor array (118) having a plurality of sensors that include virus sensors (112) which directly detect a whole vims and at least one of a biomarker sensor, antibody sensor, saturated oxygen sensor, temperature sensor, and heart rate sensor (114a-114n). The system also includes executable instructions that receive sensor output from at least a portion of sensors included in the sensor array (118), assign weights to the sensor output of individual sensors in the sensor array based (118) in part on characteristics of the individual sensors to detect the response signature associated with the pathogen, and determine whether the pathogen has been detected based on the weights assigned to the sensor output of the individual sensors. The system can output (124) an indication whether the pathogen has been detected. |
| FILED | Monday, October 26, 2020 |
| APPL NO | 17/771665 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/4145 (20130101) G01N 33/5438 (20130101) G01N 33/56983 (20130101) Original (OR) Class G01N 2333/165 (20130101) G01N 2333/185 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220413146 | Rishe |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Naphtali D. Rishe (Miami, Florida) |
| ASSIGNEE(S) | The Florida International University Board of Trustees (Miami, Florida) |
| INVENTOR(S) | Naphtali D. Rishe (Miami, Florida) |
| ABSTRACT | Systems and methods for generating ground-level terrain elevation models, preparing vector street data to assist in generating such models, and finding approximate elevation of any point using such terrain models are provided. Lidar data can be analyzed, and Lidar elevation values at roadway/street intersections can be used to determine a model of the ground-level elevation in an area or region. Outliers can be removed. The ground-level elevation at any point in the mapped area can be determined using elevation levels for nearby roadway intersections. |
| FILED | Friday, June 25, 2021 |
| APPL NO | 17/358795 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 17/89 (20130101) Original (OR) Class Electric Digital Data Processing G06F 16/29 (20190101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/0063 (20130101) Image Data Processing or Generation, in General G06T 17/05 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220413382 | Stowers et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Inpria Corporation (Corvallis, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason K. Stowers (Corvallis, Oregon); Alan J. Telecky (Albany, Oregon); Douglas A. Keszler (Corvallis, Oregon); Andrew Grenville (Corvallis, Oregon) |
| ABSTRACT | Stabilized precursor solutions can be used to form radiation inorganic coating materials. The precursor solutions generally comprise metal suboxide cations, peroxide-based ligands and polyatomic anions. Design of the precursor solutions can be performed to achieve a high level of stability of the precursor solutions. The resulting coating materials can be designed for patterning with a selected radiation, such as ultraviolet light, x-ray radiation or electron beam radiation. The radiation patterned coating material can have a high contrast with respect to material properties, such that development of a latent image can be successful to form lines with very low line-width roughness and adjacent structures with a very small pitch. |
| FILED | Thursday, August 25, 2022 |
| APPL NO | 17/895657 |
| CURRENT CPC | Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/20 (20130101) G03F 7/0042 (20130101) G03F 7/0043 (20130101) Original (OR) Class G03F 7/327 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/24355 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220413389 | Seo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | FRAUNHOFER USA, INC. (Plymouth, Michigan); The Research Foundation for The State University of New York (Buffalo, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jung-Hun Seo (Buffalo, New York); Yixiong Zheng (Amherst, New York); Matthias Muehle (Howell, Michigan) |
| ABSTRACT | A method comprising providing a carbonaceous material, the substrate having a first thermal conductivity. The method further comprises depositing a first masking layer having a second thermal conductivity on at least a portion of the substrate, a ratio of the second thermal conductivity to the first thermal conductivity being less than or equal to 1:30. The method further comprises depositing a second masking layer on the first masking layer to form an etch mask, and etching an exposed portion of the substrate. |
| FILED | Thursday, June 24, 2021 |
| APPL NO | 17/357666 |
| CURRENT CPC | Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/36 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220413618 | Colgate et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James E. Colgate (Evanston, Illinois); Michael A. Peshkin (Evanston, Illinois) |
| ABSTRACT | A touchscreen includes conductive islands that are capacitively coupled to conductive traces, where they may be used to provide capacitive sensing of the position of one or more fingers in contact with a touchscreen and/or to exert haptic forces on one or more fingers in contact with a touchscreen. |
| FILED | Tuesday, August 30, 2022 |
| APPL NO | 17/898734 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/016 (20130101) Original (OR) Class G06F 3/044 (20130101) G06F 3/0416 (20130101) G06F 3/0446 (20190501) G06F 3/04164 (20190501) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 21/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220414297 | WANG et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dan WANG (Seattle, Washington); Xu CHEN (Seattle, Washington) |
| ABSTRACT | In an example, a method includes processing an input signal using a finite element model (FEM) to generate an output signal. The input signal, the output signal, and the FEM are associated with a simulated additive manufacturing process. The method also includes adjusting the input signal based on comparing the output signal to a reference signal and thereafter processing the input signal using the FEM to generate the output signal. Examples also include a computer readable medium and a computing device related to the method. |
| FILED | Friday, November 13, 2020 |
| APPL NO | 17/775657 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/23 (20200101) Original (OR) Class G06F 30/28 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220414305 | Barker |
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| FUNDED BY |
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| APPLICANT(S) | Synopsys, Inc. (Mountain View, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aaron John Barker (Broomfield, Colorado) |
| ABSTRACT | Samples of metrics measured on physical devices are selected from a larger number of samples. The samples are selected based on the distributions of the measured metrics. A set of model instances are constructed that correspond to the selected set of samples. The model instances have parameters, which are set such that simulation of the model instances using the parameters predicts metrics that match the measured metrics from the set of samples. The principal components of the variances of the parameters is calculated. Non-linear models are fitted to the parameter variances as a function of the principal components. Statistical variations of the principal components are applied to the non-linear models to yield statistical variations in the parameters; and these are applied to simulations of model instances to yield statistical variations of a property of the device being simulated. |
| FILED | Tuesday, June 29, 2021 |
| APPL NO | 17/362417 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/3308 (20200101) Original (OR) Class G06F 2111/10 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220414483 | Shen et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Dennis Shen (Irvine, California); Devavrat D. Shah (Waban, Massachusetts); Anish Agarwal (Newton, Massachusetts) |
| ABSTRACT | A computer-implemented method includes: identifying, from first and second data, interventions common to a target unit and one or more of a plurality of donor units as filtered donor units, the first data corresponding to the target unit under one or more interventions, the second data corresponding to the plurality of donor units each under one or more interventions; identifying, from the first data, third data corresponding to the target unit under the common interventions; identifying, from the second data, fourth data corresponding to the filtered donor units under the common interventions; identifying, from the second data, fifth data corresponding to the filtered donor units under a subject intervention; generating, from the third and fourth data, a learned model representing to a relationship between the target unit and the filtered donor units; applying the learned model to the fifth data to generate the synthetic data; and outputting the synthetic data. |
| FILED | Monday, April 11, 2022 |
| APPL NO | 17/658712 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 5/022 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220415351 | Singer et al. |
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| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenneth Singer (Cleveland, Ohio); Irina Shiyanovskaya (Solon, Ohio) |
| ABSTRACT | An optical information storage medium includes a substrate and a multilayer polymeric film. The multilayer polymeric film has a first surface and an opposite second surface that extend the length of the multilayer polymeric film. The second surface is adhered to a surface of the substrate. The multilayer polymeric film includes a plurality of coextruded alternating polymeric active data storage layers and polymeric buffer layers. |
| FILED | Thursday, March 12, 2020 |
| APPL NO | 17/438820 |
| CURRENT CPC | Information Storage Based on Relative Movement Between Record Carrier and Transducer G11B 7/26 (20130101) G11B 7/0052 (20130101) G11B 7/0079 (20130101) G11B 7/242 (20130101) G11B 7/24027 (20130101) G11B 7/24038 (20130101) Original (OR) Class G11B 7/24056 (20130101) G11B 7/24065 (20130101) G11B 2007/0013 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20220411268 | Arnold et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Scott Arnold (Middleton, Wisconsin); Austin James Way (Madison, Wisconsin); Robert Michael Jacobberger (Evanston, Illinois) |
| ABSTRACT | Methods for the bottom-up growth of graphene nanoribbons are provided. The methods utilize small aromatic molecular seeds to initiate the anisotropic chemical vapor deposition (CVD) growth of graphene nanoribbons having low size polydispersities on the surface of a growth substrate. The aromatic molecular seeds include polycyclic aromatic hydrocarbons (PAHs), functionalized derivatives of PAHs, heterocyclic aromatic molecules, and metal complexes of heterocyclic aromatic molecules. |
| FILED | Monday, June 28, 2021 |
| APPL NO | 17/360108 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/186 (20170801) Original (OR) Class C01B 2204/065 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2004/17 (20130101) C01P 2004/64 (20130101) Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 29/02 (20130101) C30B 29/54 (20130101) C30B 29/60 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411272 | HOLLAND |
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| FUNDED BY |
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| APPLICANT(S) | Consolidated Nuclear Security, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Justin Matthew HOLLAND (Clinton, Tennessee) |
| ABSTRACT | Systems and methods for converting metal oxide to metal using metal carbide as an intermediate, include: reacting the metal oxide with carbon to produce the metal carbide, wherein the metal carbide is in a form of powder or pellets; and subjecting the metal carbide produced from the metal oxide and the carbon to electrolysis in an electrorefiner to produce and purify the metal. |
| FILED | Thursday, June 10, 2021 |
| APPL NO | 17/344406 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/914 (20170801) Original (OR) Class Processes for the Electrolytic Production, Recovery or Refining of Metals; Apparatus Therefor C25C 5/04 (20130101) C25C 7/06 (20130101) C25C 7/025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411348 | Dagle et al. |
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| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Vanessa Dagle (Richland, Washington); Robert A. Dagle (Richland, Washington) |
| ABSTRACT | Systems for preparing butenes are provided. The systems can include a reactor inlet coupled to both a reactor and at least one reactant reservoir; at least one of the reactant reservoirs containing one or both of an aldehyde and/or ethanol; a catalyst within the reactor, the catalyst comprising a metal component and an acidic support material; and a reactor outlet operationally configured to convey a butene-rich reaction product to a product reservoir. Methods for preparing butenes are also provided. The methods can include exposing one or both of ethanol and/or an aldehyde to a catalyst comprising a metal component and an acidic support to form a butene-rich product that comprises one or both of 1-butene and/or 2-butene. |
| FILED | Wednesday, June 22, 2022 |
| APPL NO | 17/846476 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 8/24 (20130101) B01J 8/1881 (20130101) B01J 21/08 (20130101) B01J 21/066 (20130101) B01J 23/72 (20130101) Acyclic or Carbocyclic Compounds C07C 1/22 (20130101) Original (OR) Class C07C 2521/06 (20130101) C07C 2521/08 (20130101) C07C 2523/72 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411373 | Cooks et al. |
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| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Graham Cooks (West Lafayette, Indiana); Christopher Pulliam (West Lafayette, Indiana); Ryan M. Bain (West Lafayette, Indiana) |
| ABSTRACT | The invention generally relates to conducting reactions in Leidenfrost-levitated droplets. |
| FILED | Tuesday, August 23, 2022 |
| APPL NO | 17/893399 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 45/72 (20130101) Heterocyclic Compounds C07D 209/40 (20130101) C07D 213/04 (20130101) Original (OR) Class Steroids C07J 41/0005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411445 | Anderson et al. |
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| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John S. Anderson (Chicago, Illinois); Jiaze Xie (Chicago, Illinois); Noah E. Horwitz (Chicago, Illinois); Airi Kawamura (Santa Cruz, California) |
| ABSTRACT | Coordination complexes of tetrathiafulvalene-based dithiolene linkers, such as tetrathiafulvalene-2,3,6,7-tetrathiolate (TTFtt), and their oxidation products are described. The coordination complexes can include metals such as tin or silicon. Also described are methods of using the coordination complexes in transmetallation reactions, e.g., to prepare sulfur coordination polymers, and sulfur coordination polymers doped with tetrathiafulvalene-based dithiolene linkers having different oxidation states. |
| FILED | Thursday, October 22, 2020 |
| APPL NO | 17/771266 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/226 (20130101) Original (OR) Class C07F 7/0814 (20130101) C07F 15/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411453 | Lu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fachuang Lu (Madison, Wisconsin); John Ralph (Madison, Wisconsin) |
| ABSTRACT | A method of completely dissolving lignocellulosic biomass. The method includes the steps of dissolving a sample of biomass in an aqueous solution of strong acid and an amine-thiol to yield a first solution. A method for measuring lignin concentration in biomass via absorbance of the first solution at a wavelength of about 283 nm by comparing the measured absorbance to a standard curve of absorbance values made from solutions of known lignin concentration. |
| FILED | Thursday, June 09, 2022 |
| APPL NO | 17/836061 |
| CURRENT CPC | Compounds of Unknown Constitution C07G 1/00 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/31 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411454 | KRUGER et al. |
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| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado); Massachusetts Institute of Technology (CAMBRIDGE, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jacob S. KRUGER (Arvada, Colorado); Gregg Tyler BECKHAM (Golden, Colorado); David Gregory BRANDNER (Golden, Colorado); Andrew Wolf BARTLING (Golden, Colorado); Yuriy ROMÁN (Cambridge, Massachusetts); Jun Hee JANG (Lakewood, Colorado); Nicholas Earl Thornburg (Denver, Colorado); Gregory George Facas (Moorestown, New Jersey) |
| ABSTRACT | Described herein are devices and methods for the efficient and economic generation of lignin monomers from biomass. The provided devices and methods utilize reductive catalytic fractionation with an organic solvent to extract high-quality lignin from biomass and cleave specific lignin bonds to generate valuable lignin monomers with a relatively narrow product slate. Advantageously, the devices and methods described herein utilize solvent recycling, multiple solvolysis chambers with multiple biomass beds and/or physical agitation (e.g., use of a screw extruder) to reduce the amount of solvent required and increase economic efficiency and monomer yield. |
| FILED | Thursday, June 16, 2022 |
| APPL NO | 17/842062 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 8/0278 (20130101) B01J 21/18 (20130101) B01J 23/755 (20130101) Compounds of Unknown Constitution C07G 1/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411806 | Lynch et al. |
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| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Lynch (Durham, North Carolina); Romel Menacho Melgar (Durham, North Carolina); Zhixia Ye (Raleigh, North Carolina); Eirik A. Moreb (Durham, North Carolina) |
| ABSTRACT | Improved production of recombinant proteins in E. coli, reliant on tightly controlled autoinduction, triggered by phosphate depletion in stationary phase. The process also provides an optimized autoinduction media, enabling routine batch production at various culture volumes where cells densities routinely reach ˜5-7 g cell dry weight per liter and offer protein titers above 2 g/L. The methodology has been validated with a set of diverse heterologous proteins and is of general use for the facile optimization of routine protein expression from high throughput screens to fed-batch fermentation. |
| FILED | Friday, October 23, 2020 |
| APPL NO | 17/755158 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 15/70 (20130101) C12N 15/635 (20130101) Original (OR) Class C12N 2500/14 (20130101) C12N 2500/16 (20130101) C12N 2500/24 (20130101) C12N 2500/42 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411921 | PEGNA et al. |
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| FUNDED BY |
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| APPLICANT(S) | FREE FORM FIBERS, LLC (Saratoga Springs, New York) |
| ASSIGNEE(S) | FREE FORM FIBERS, LLC (Saratoga Springs, New York) |
| INVENTOR(S) | Joseph PEGNA (Saratoga Springs, New York); Kirk L. WILLIAMS (Saratoga Springs, New York); Shay L. HARRISON (East Schodack, New York) |
| ABSTRACT | Methods of forming a ceramic matrix, as well as fiber preforms and methods of forming fiber preforms to facilitate formation of a ceramic matrix are provided. The method includes obtaining a fiber preform to facilitate forming the ceramic matrix. The fiber preform includes a fiber layer with a plurality of fibers and a heating element embedded within the fiber preform. The method also includes heating the fiber preform via the heating element embedded within the fiber preform, and depositing matrix material into the fiber preform by embedded wire chemical vapor deposition (EWCVD) of the matrix material during the heating of the fiber preform by the heating element. The chemical vapor deposition of the matrix material within the fiber preform facilitates formation of the ceramic matrix. |
| FILED | Thursday, April 28, 2022 |
| APPL NO | 17/661059 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/44 (20130101) Original (OR) Class Electric Heating; Electric Lighting Not Otherwise Provided for H05B 3/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220411948 | Lu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Dongping Lu (Richland, Washington); Robert M. Asmussen (West Richland, Washington); Li-Jung Kuo (Sequim, Washington); Jiangtao Hu (Shenzhen, China PRC) |
| ABSTRACT | A method that includes contacting a Li-containing aqueous liquid with a Li ion-selective membrane while simultaneously applying an electric field thereby extracting Li ions from the Li-containing aqueous liquid; and intercalating the extracted Li ions into a cathode material. |
| FILED | Friday, June 17, 2022 |
| APPL NO | 17/843392 |
| CURRENT CPC | Production and Refining of Metals; Pretreatment of Raw Materials C22B 3/42 (20130101) C22B 26/12 (20130101) Processes for the Electrolytic Production, Recovery or Refining of Metals; Apparatus Therefor C25C 1/02 (20130101) Original (OR) Class Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/0459 (20130101) H01M 4/505 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220412002 | HU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Liangbing HU (Potomac, Maryland); Chaoji CHEN (Greenbelt, Maryland); Zhihan LI (College Park, Maryland); Jiaqi DAI (Washington, District of Columbia) |
| ABSTRACT | Natural bamboo is chemically treated to remove at least some lignin therefrom. As a result, the bamboo becomes more porous and less rigid, while otherwise retaining the aligned microstructure of bamboo fibers and constituent cellulose nanofibers. In some embodiments, the treated bamboo can then be pressed such that the lumina therein at least partially collapse, thereby improving the strength and toughness of the bamboo among other properties. In some embodiments, the treated bamboo can be infiltrated with a polymer or polymer precursor, and/or have non-native particles added to surfaces thereof to tailor properties of the resulting bamboo structure. By further modifying, manipulating, or machining the treated bamboo, it can be adapted to various applications. |
| FILED | Wednesday, November 25, 2020 |
| APPL NO | 17/778690 |
| CURRENT CPC | Production of Cellulose by Removing Non-cellulose Substances From Cellulose-containing Materials; Regeneration of Pulping Liquors; Apparatus Therefor D21C 5/022 (20130101) Original (OR) Class D21C 9/007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220412251 | PEDERSEN et al. |
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| FUNDED BY |
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| APPLICANT(S) | ONBOARD DYNAMICS LLC (Bend, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel S. PEDERSEN (Fort Collins, Colorado); Guy R. BABBITT (Fort Collins, Colorado); Kristina WEYER-GEIGEL (Yakima, Washington) |
| ABSTRACT | Typically, an engine-compressor for compressing natural gas for use as a fuel has a single cooling circuit to cool both its combustion unit and compression unit. A single cooling circuit design is not ideal because the optimal temperature for the combustion unit is higher than the compression unit of the engine-compressor. The present invention provides a dual zone cooling system to cool the combustion unit separately from the compression unit. |
| FILED | Friday, February 11, 2022 |
| APPL NO | 17/670185 |
| CURRENT CPC | Cooling of Machines or Engines in General; Cooling of Internal-combustion Engines F01P 3/02 (20130101) F01P 2003/021 (20130101) Internal-combustion Piston Engines; Combustion Engines in General F02B 43/04 (20130101) Original (OR) Class F02B 43/12 (20130101) F02B 2043/103 (20130101) Supplying Combustion Engines in General With Combustible Mixtures or Constituents Thereof F02M 21/0245 (20130101) F02M 31/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220412557 | Fetvedt et al. |
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| FUNDED BY |
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| APPLICANT(S) | 8 Rivers Capital, LLC (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeremy Eron Fetvedt (Raleigh, North Carolina); Xijia Lu (Durham, North Carolina); Brent Gregory (Scottsdale, Arizona); Chris Bonilha (Phoenix, Arizona); James Lenertz (Scottsdale, Arizona); Stefan Tschirren (Laufen, Switzerland); Hassan Abdulsater (Gilbert, Arizona) |
| ABSTRACT | The present disclosure relates to apparatuses and methods that are useful for one or more aspects of a power production plant. More particularly, the disclosure relates to combustor apparatuses and methods for a combustor adapted to utilize different fuel mixtures derived from gasification of a solid fuel. Combustion of the different fuel mixtures within the combustor can be facilitated by arranging elements of the combustor controlled so that a defined set of combustion characteristics remains substantially constant across a range of different fuel mixtures. |
| FILED | Wednesday, August 17, 2022 |
| APPL NO | 17/889833 |
| CURRENT CPC | Internal-combustion Piston Engines; Combustion Engines in General F02B 43/12 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 3/22 (20130101) Methods or Apparatus for Combustion Using Only Solid Fuel F23B 90/06 (20130101) Burners F23D 14/24 (20130101) F23D 2214/00 (20130101) Cremation Furnaces; Consuming Waste Products by Combustion F23G 5/027 (20130101) Supplying Air or Non-combustible Liquids or Gases to Combustion Apparatus in General; Valves or Dampers Specially Adapted for Controlling Air Supply or Draught in Combustion Apparatus; Inducing Draught in Combustion Apparatus; Tops for Chimneys or Ventilating Shafts; Terminals for Flues F23L 7/007 (20130101) Casings, Linings, Walls or Doors Specially Adapted for Combustion Chambers, e.g Firebridges; Devices for Deflecting Air, Flames or Combustion Products in Combustion Chambers; Safety Arrangements Specially Adapted for Combustion Apparatus; Details of Combustion Chambers, Not Otherwise Provided for F23M 5/085 (20130101) Original (OR) Class Generating Combustion Products of High Pressure or High Velocity, e.g Gas-turbine Combustion Chambers F23R 3/002 (20130101) F23R 3/12 (20130101) F23R 2900/03041 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220413082 | Hui et al. |
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| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaonan Hui (Ithaca, New York); Edwin C. Kan (Ithaca, New York) |
| ABSTRACT | A radio-frequency method for range finding includes modulating a reference signal having an intermediate frequency to a downlink signal having a carrier frequency using a clock signal. The downlink signal is transmitted to a tag using a transceiver. An uplink signal backscattered front the tag is received and demodulated using the clock signal. The uplink signal has a frequency that is a harmonic of the carrier frequency. A distance between the tag and the transceiver is calculated based on a phase of the demodulated uplink signal. A system for range finding includes a transceiver and a processor. The transceiver modulates a reference signal to downlink signal and transmits the downlink signal. The transceiver receives and demodulates an uplink signal. The processor is configured to receive the demodulated uplink signal and calculate a distance between the tag and the transceiver using a phase of the demodulated uplink signal. |
| FILED | Wednesday, August 31, 2022 |
| APPL NO | 17/900480 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 1/022 (20130101) G01S 1/306 (20130101) Original (OR) Class G01S 1/0428 (20190801) G01S 13/84 (20130101) G01S 13/751 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220414508 | Shyamsundar |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Fermi Research Alliance, LLC (Batavia, Illinois) |
| ASSIGNEE(S) | Fermi Research Alliance, LLC (Batavia, Illinois) |
| INVENTOR(S) | Prasanth Shyamsundar (Chicago, Illinois) |
| ABSTRACT | Generalizations of quantum amplitude amplification and amplitude estimation algorithms work with non-boolean oracles (by way of definition, the action of a non-boolean oracle Uφ on an eigenstate |x |
| FILED | Monday, June 28, 2021 |
| APPL NO | 17/360792 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Original (OR) Class Pulse Technique H03K 19/195 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220415525 | Peterson et al. |
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| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Luc Peterson (Livermore, California); Scott T. Brandon (Livermore, California); John E. Field (Livermore, California); Kelli Denise Humbird (Livermore, California); Steve Langer (Livermore, California); Ryan Charles Nora (Livermore, California); Brian K. Spears (Livermore, California) |
| ABSTRACT | Methods, devices and system for asymmetric inertial confinement fusion are disclosed. One method includes a fixing in position a target capsule comprising an inertial confinement fusion fuel, where the target capsule is substantially spherical. The method further includes for applying an oscillatory compression to the target capsule. The oscillatory compression includes compression at a first time in a radial direction orthogonal to a diametric axis of the target capsule, and compression at a second time along the diametric axis to drive the target capsule into driven into an ovoid shape. The oval shaped target can implode upon being further driven at a third time. |
| FILED | Tuesday, July 19, 2022 |
| APPL NO | 17/813477 |
| CURRENT CPC | Fusion Reactors G21B 1/03 (20130101) Original (OR) Class G21B 1/19 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220416112 | SCHULTE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado); Colorado School of Mines (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin Louis SCHULTE (Denver, Colorado); Corinne Evelyn PACKARD (Lakewood, Colorado); Jason Michael CHENENKO (Hampton, Virginia) |
| ABSTRACT | The present disclosure relates to a composition that includes a III-V planar substrate having a surface aligned with and parallel to a reference plane, where the surface includes a plurality of terraces, each terrace includes a first surface positioned between a first boundary and a second boundary, each boundary is substantially parallel to the other boundaries and positioned substantially parallel to the reference plane, and each terrace is separated from an adjacent terrace by a second surface positioned between the second boundary of the terrace and the first boundary of the adjacent terrace. |
| FILED | Wednesday, June 29, 2022 |
| APPL NO | 17/809841 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/036 (20130101) H01L 31/184 (20130101) Original (OR) Class H01L 31/0304 (20130101) H01L 31/0735 (20130101) H01L 31/1892 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220416218 | Oakes et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PPG Industries Ohio, Inc. (Cleveland, Ohio) |
| ASSIGNEE(S) | PPG Industries Ohio, Inc. (Cleveland, Ohio) |
| INVENTOR(S) | Landon J. Oakes (Cambridge, Massachusetts); Haley L. Orler (Bridgeville, Pennsylvania); Stuart D. Hellring (Pittsburgh, Pennsylvania) |
| ABSTRACT | The present invention is directed toward a coating system for electrodepositing a battery electrode coating onto a foil substrate, the system comprising a tank structured and arranged to hold an electrodepositable coating composition; a feed roller positioned outside of the tank structured and arranged to feed the foil into the tank; at least one counter electrode positioned inside the tank, the counter electrode in electrical communication with the foil during operation of the system to thereby deposit the battery electrode coating onto the foil; and an in-line foil drier positioned outside the tank structured and arranged to receive the coated foil from the tank. Also disclosed are methods for electrocoating battery electrode coatings onto conductive foil substrates, coated foil substrates, and electrical storage devices comprising the coated foil substrates. |
| FILED | Monday, August 29, 2022 |
| APPL NO | 17/823046 |
| CURRENT CPC | Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 13/16 (20130101) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/28 (20130101) H01G 11/50 (20130101) H01G 11/86 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/0435 (20130101) H01M 4/0457 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220416260 | Wu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Research Foundation for The State University of New York (Buffalo, New York); Giner, Inc. (Newton, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gang Wu (Clarence Center, New York); Yachao Zeng (Buffalo, New York); Zhi Qiao (Bryan, Texas); Hui Xu (Acton, Massachusetts); Shuo Ding (Boston, Massachusetts) |
| ABSTRACT | Hybrid catalyst suitable for use in a proton exchange membrane fuel cell and method of preparing same. In one embodiment, the hybrid catalyst is iron-free and includes an Mn—N—C support and platinum-containing nanoparticles that are dispersed on the Mn—N—C support. The Mn—N—C support preferably comprises atomically dispersed and nitrogen coordinated MnN4 moieties and has a particle size of about 30 to 200 nm. The platinum-containing nanoparticles preferably have a particle size ranging from about 2 to 8 nm and are made of platinum or a platinum-cobalt intermetallic alloy, such as a cubic L12 Pt3Co alloy or a tetragonal L10 PtCo alloy. The hybrid catalyst may be made by combining a quantity of a hexachloroplatinic acid solution with a quantity of an Mn—N—C support, sonicating the mixture in an ice bath, freeze-drying the sonicated product, calcinating the freeze-dried product under a forming gas, and heating the calcinated product. |
| FILED | Friday, June 24, 2022 |
| APPL NO | 17/849275 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/926 (20130101) Original (OR) Class H01M 4/8882 (20130101) H01M 8/1004 (20130101) H01M 2004/8689 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220416494 | Filgas |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | David M. Filgas (Newbury Park, California) |
| ASSIGNEE(S) | David M. Filgas (, None) |
| INVENTOR(S) | David M. Filgas (Newbury Park, California) |
| ABSTRACT | A solid state laser module for amplification of laser radiation including a laser gain medium disk. The disk has a pair of generally parallel surfaces that receive, reflect, or transmit laser radiation. At least one perimetral optical medium is disposed adjacent a peripheral edge of the laser gain medium disk and in optical communication therewith. A source of optical pump radiation directs optical pump radiation through the perimetral optical medium and into the laser gain medium disk to pump the laser gain medium to produce optical gain at the laser wavelength. A dichroic beam splitter is located between the optical pump source and the perimetral optical medium to prevent amplified spontaneous emission generated within the laser gain medium from illuminating the source of optical pump radiation. |
| FILED | Wednesday, November 18, 2020 |
| APPL NO | 16/974221 |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/025 (20130101) Original (OR) Class H01S 3/042 (20130101) H01S 3/0405 (20130101) H01S 3/0604 (20130101) H01S 3/09415 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220416684 | Awal et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | M A Awal (Raleigh, North Carolina); Srdjan Lukic (Raleigh, North Carolina); Iqbal Husain (Raleigh, North Carolina) |
| ABSTRACT | Disclosed herein is a modular, scalable, and galvanically isolated power electronics converter topology for medium voltage AC (MVAC) to DC or high voltage AC (HVAC) to DC power conversion. A disclosed modular converter can comprise a low-voltage direct current bus and a centralized controller configured to regulate the low-voltage direct current bus. The modular converter can further comprise a plurality of three-phase blocks connected in series. Individual three-phase blocks of the plurality of three-phase blocks can comprise a plurality of single-phase modules connected in an input-series output-parallel configuration. The modular converter can further comprise a filter connected between a grid input and the plurality of three-phase blocks and a pulse-width modulator configured to generate encoded gate pulses for the individual three-phase blocks of the plurality of three-phase blocks. |
| FILED | Thursday, May 26, 2022 |
| APPL NO | 17/825211 |
| CURRENT CPC | Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/0012 (20210501) H02M 1/045 (20130101) H02M 1/0067 (20210501) H02M 7/219 (20130101) H02M 7/2173 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20220413007 | GRINOLDS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Michael S. GRINOLDS (Cambridge, Massachusetts); Sungkun HONG (Cambridge, Massachusetts); Patrick MALETINSKY (Cambridge, Massachusetts); Amir YACOBY (Cambridge, Massachusetts) |
| ABSTRACT | A sensing probe may be formed of a diamond material comprising one or more spin defects that are configured to emit fluorescent light and are located no more than 50 nm from a sensing surface of the sensing probe. The sensing probe may include an optical outcoupling structure formed by the diamond material and configured to optically guide the fluorescent light toward an output end of the optical outcoupling structure. An optical detector may detect the fluorescent light that is emitted from the spin defects and that exits through the output end of the optical outcoupling structure after being optically guided therethrough. A mounting system may hold the sensing probe and control a distance between the sensing surface of the sensing probe and a surface of a sample while permitting relative motion between the sensing surface and the sample surface. |
| FILED | Friday, February 18, 2022 |
| APPL NO | 17/675156 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/645 (20130101) G01N 24/10 (20130101) Scanning-probe Techniques or Apparatus; Applications of Scanning-probe Techniques, e.g Scanning Probe Microscopy [SPM] G01Q 30/025 (20130101) G01Q 60/38 (20130101) G01Q 60/54 (20130101) G01Q 70/14 (20130101) Original (OR) Class Measuring Electric Variables; Measuring Magnetic Variables G01R 33/022 (20130101) G01R 33/032 (20130101) G01R 33/60 (20130101) G01R 33/1284 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220413135 | Gorman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason John Gorman (Silver Spring, Maryland); Thomas Warren LeBrun (Washington, District of Columbia); David Alexander Long (Bethesda, Maryland) |
| ABSTRACT | An optomechanical ultrasound detector includes: a micromirror substrate; a mechanical resonator that receives ultrasound waves, oscillates at resonator frequency fr, changes cavity length Lc, and produces intra-cavity light; and an optical microcavity between the micromirror substrate and the mechanical resonator with cavity length Lc and cavity resonance frequency fc formed by the mechanical resonator and the micromirror substrate, such that the micromirror substrate produces cavity output light from the intra-cavity light, wherein the cavity output light optically encodes information about the ultrasound waves received by the mechanical resonator. |
| FILED | Wednesday, June 29, 2022 |
| APPL NO | 17/853106 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/52023 (20130101) G01S 7/52079 (20130101) G01S 15/8915 (20130101) G01S 15/8968 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 20220412947 | Javanmard et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | Mehdi Javanmard (West Windsor, New Jersey); Robert Miskewitz (Cranford, New Jersey); Ali Maher (Skillman, New Jersey); Clifton Lacy (Highland Park, New Jersey); Azam Gholizadeh (Blacksburg, Virginia) |
| ABSTRACT | A sensor apparatus for detecting a heavy metal in a sample. |
| FILED | Wednesday, December 16, 2020 |
| APPL NO | 17/757780 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/42 (20130101) G01N 27/308 (20130101) G01N 33/20 (20130101) G01N 33/24 (20130101) G01N 33/1813 (20130101) G01N 33/48714 (20130101) Original (OR) Class G01N 2001/4038 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220413164 | SHAPIRO |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The MITRE Corporation (McLean, Virginia) |
| ASSIGNEE(S) | The MITRE Corporation (McLean, Virginia) |
| INVENTOR(S) | Jerome Mark SHAPIRO (McLean, Virginia) |
| ABSTRACT | Presented herein are systems and methods for generating a consistent set of signals to be processed by a PVT processor. In one or more examples, a GNSS receiver can receive a plurality of signals from a plurality of signal sources. In one or more examples, the systems and methods can generate clusters that have been vetted using cost functions so as to maximize the probability that any cluster that is sent to the PVT processor contains legitimate GNSS signals, and does not include any spoofed or otherwise illegitimate signals, thereby maximizing the probability that a PVT solution produced by the PVT processor is accurate. |
| FILED | Monday, June 27, 2022 |
| APPL NO | 17/850484 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 19/08 (20130101) G01S 19/40 (20130101) G01S 19/52 (20130101) G01S 19/396 (20190801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20220408776 | KOZUBAL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Fynder Group, Inc. (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark A. KOZUBAL (Bozeman, Montana); Richard E. MACUR (Manhattan, Montana); Yuval C. AVNIEL (Missoula, Montana); Maximilian DeVane HAMILTON (Bozeman, Montana) |
| ABSTRACT | Methods of production of edible filamentous fungal biomat formulations are provided as standalone protein sources and/or protein ingredients in foodstuffs as well as a one-time use or repeated use self-contained biofilm-biomat reactor comprising a container with at least one compartment and placed within the compartment(s), a feedstock, a fungal inoculum, a gas-permeable membrane, and optionally a liquid nutrient medium. |
| FILED | Friday, August 19, 2022 |
| APPL NO | 17/891873 |
| CURRENT CPC | Dairy Products, e.g Milk, Butter, Cheese; Milk or Cheese Substitutes; Making Thereof A23C 9/1203 (20130101) Cocoa; Cocoa Products, e.g Chocolate; Substitutes for Cocoa or Cocoa Products; Confectionery; Chewing Gum; Ice-cream; Preparation Thereof A23G 9/36 (20130101) Protein Compositions for Foodstuffs; Working-up Proteins for Foodstuffs; Phosphatide Compositions for Foodstuffs A23J 3/20 (20130101) A23J 3/227 (20130101) Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 29/065 (20160801) A23L 31/00 (20160801) Original (OR) Class A23L 33/195 (20160801) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) A23V 2250/208 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/00 (20130101) C12M 23/24 (20130101) C12M 23/34 (20130101) C12M 23/40 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/14 (20130101) C12N 1/145 (20210501) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/77 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220412635 | Closs et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MiTeGen, LLC (Ithaca, New York) |
| ASSIGNEE(S) | MiTeGen, LLC (Ithaca, New York) |
| INVENTOR(S) | David Closs (Freeville, New York); Stephen Hollabaugh (Ithaca, New York); Robert E. Thorne (Ithaca, New York); Robert Newman (Groton, New York); Benjamin A. Apker (Ithaca, New York) |
| ABSTRACT | A cryogenic cooling manifold and methods incorporating a cryogenic cooling manifold for managing the gas layer(s) above a liquid cryogen to control cooling temperature-time profiles and ice formation for microliter and smaller samples that are plunged through the gas and into the liquid cryogen. |
| FILED | Thursday, September 01, 2022 |
| APPL NO | 17/901050 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0252 (20130101) Refrigerators; Cold Rooms; Ice-boxes; Cooling or Freezing Apparatus Not Otherwise Provided for F25D 3/10 (20130101) Original (OR) Class F25D 2400/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20220408776 | KOZUBAL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Fynder Group, Inc. (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark A. KOZUBAL (Bozeman, Montana); Richard E. MACUR (Manhattan, Montana); Yuval C. AVNIEL (Missoula, Montana); Maximilian DeVane HAMILTON (Bozeman, Montana) |
| ABSTRACT | Methods of production of edible filamentous fungal biomat formulations are provided as standalone protein sources and/or protein ingredients in foodstuffs as well as a one-time use or repeated use self-contained biofilm-biomat reactor comprising a container with at least one compartment and placed within the compartment(s), a feedstock, a fungal inoculum, a gas-permeable membrane, and optionally a liquid nutrient medium. |
| FILED | Friday, August 19, 2022 |
| APPL NO | 17/891873 |
| CURRENT CPC | Dairy Products, e.g Milk, Butter, Cheese; Milk or Cheese Substitutes; Making Thereof A23C 9/1203 (20130101) Cocoa; Cocoa Products, e.g Chocolate; Substitutes for Cocoa or Cocoa Products; Confectionery; Chewing Gum; Ice-cream; Preparation Thereof A23G 9/36 (20130101) Protein Compositions for Foodstuffs; Working-up Proteins for Foodstuffs; Phosphatide Compositions for Foodstuffs A23J 3/20 (20130101) A23J 3/227 (20130101) Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 29/065 (20160801) A23L 31/00 (20160801) Original (OR) Class A23L 33/195 (20160801) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) A23V 2250/208 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/00 (20130101) C12M 23/24 (20130101) C12M 23/34 (20130101) C12M 23/40 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/14 (20130101) C12N 1/145 (20210501) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/77 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Office of the Director of National Intelligence (ODNI)
| US 20220414305 | Barker |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Synopsys, Inc. (Mountain View, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aaron John Barker (Broomfield, Colorado) |
| ABSTRACT | Samples of metrics measured on physical devices are selected from a larger number of samples. The samples are selected based on the distributions of the measured metrics. A set of model instances are constructed that correspond to the selected set of samples. The model instances have parameters, which are set such that simulation of the model instances using the parameters predicts metrics that match the measured metrics from the set of samples. The principal components of the variances of the parameters is calculated. Non-linear models are fitted to the parameter variances as a function of the principal components. Statistical variations of the principal components are applied to the non-linear models to yield statistical variations in the parameters; and these are applied to simulations of model instances to yield statistical variations of a property of the device being simulated. |
| FILED | Tuesday, June 29, 2021 |
| APPL NO | 17/362417 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/3308 (20200101) Original (OR) Class G06F 2111/10 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20220412266 | Shealy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Shealy (Cincinnati, Ohio); Donald M. Corsmeier (West Chester, Ohio) |
| ABSTRACT | Apparatuses are provided herein useful to sealing a gap between a movable flap and a stationary structure, such as a gap between a gas turbine engine nozzle flap and a corresponding sidewall. An apparatus for sealing such a gap may be a dynamic skirted leaf seal which may include a flap arm, a wall arm opposite the flap arm, and a support arm disposed between the flap and wall arms. A distal end portion of the flap arm may comprise a first skirt and a distal end portion of the support arm may comprise a second skirt that engages the first skirt. When positioned in a gap, the skirted leaf seal may exert a force to urge the first flap arm towards the flap and to urge the wall arm and the support arm towards the structure to seal the gap. |
| FILED | Tuesday, June 29, 2021 |
| APPL NO | 17/361479 |
| CURRENT CPC | Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/28 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2240/55 (20130101) Pistons; Cylinders; Sealings F16J 15/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220412464 | Shealy |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Shealy (Cincinnati, Ohio) |
| ABSTRACT | An apparatus for sealing such a gap may be a plunger seal which may include a flap arm comprising resilient sheets and a wall arm comprising resilient sheets. A proximal end portion of the flap arm may include a closeout seal coupled to the flap. A proximal end portion of the wall arm may include a plunger having a geometry corresponding to that of the closeout seal so the plunger may be matingly received by the closeout seal. When positioned in a gap, the plunger seal may exert a force to urge the flap arm towards the flap and to urge the wall arm and resilient sheet towards the structure to seal the gap. |
| FILED | Tuesday, June 29, 2021 |
| APPL NO | 17/362391 |
| CURRENT CPC | Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/28 (20130101) Pistons; Cylinders; Sealings F16J 15/3436 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220414376 | Boroughs et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Grant B. Boroughs (Southlake, Texas); John J. Coogan (Bedford, Texas); Lisa A. McCoy (Springfield, Texas) |
| ABSTRACT | A fully-automated computer-implemented system and method for generating a road network map from a remote sensing (RS) image in which the classification accuracy is satisfactory combines moving vehicle detection with spectral classification to overcome the limitations of each. Moving vehicle detections from an RS image are used as seeds to extract and characterize image-specific spectral roadway signatures from the same RS image. The RS image is then searched and the signatures matched against the scene to grow a road network map. The entire process can be performed using the radiance measurements of the scene without having to perform the complicated geometric and atmospheric conversions, thus improving computational efficiency, the accuracy of moving vehicle detection (location, speed, heading) and ultimately classification accuracy. |
| FILED | Friday, June 25, 2021 |
| APPL NO | 17/358850 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00637 (20130101) G06K 9/00651 (20130101) Original (OR) Class G06K 9/00825 (20130101) G06K 9/6202 (20130101) G06K 2009/00644 (20130101) G06K 2009/4657 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
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Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, December 29, 2022.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
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FUNDED BY
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Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
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Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20221229.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
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