FedInvent™ Patents

Patent Details for Tuesday, January 18, 2022

This page was updated on Wednesday, January 19, 2022 at 01:07 AM GMT

Department of Health and Human Services (HHS)

11224356 — MRI-feedback control of ultrasound based mechanical fractionation of biological tissue

US 11224356	Partanen et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	Ari Ilkka Mikael Partanen (Andover, Massachusetts); Wayne Kreider (Seattle, Washington); Vera Khokhlova (Seattle, Washington)
ASSIGNEE(S)	University of Washington (Seattle, Washington); Koninklijke Philips N.V., a corporation organized and existing under the laws of Kingdom of Netherlands (Eindhoven, Netherlands)
INVENTOR(S)	Ari Ilkka Mikael Partanen (Andover, Massachusetts); Wayne Kreider (Seattle, Washington); Vera Khokhlova (Seattle, Washington)
ABSTRACT	Disclosed herein are example embodiments of devices, systems, and methods for mechanical fractionation of biological tissue using magnetic resonance imaging (MRI) feedback control. The examples may involve displaying an image representing first MRI data corresponding to biological tissue, and receiving input identifying one or more target regions of the biological tissue to be mechanically fractionated via exposure to first ultrasound waves. The examples may further involve applying the first ultrasound waves and, contemporaneous to or after applying the first ultrasound waves, acquiring second MRI data corresponding to the biological tissue. The examples may also involve determining, based on the second MRI data, one or more second parameters for applying second ultrasound waves to the biological tissue, and applying the second ultrasound waves to the biological tissue according to the one or more second parameters.
FILED	Friday, June 17, 2016
APPL NO	15/737670
ART UNIT	3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/01 (20130101) A61B 5/02 (20130101) A61B 5/0035 (20130101) A61B 5/055 (20130101) Original (OR) Class A61B 2090/374 (20160201) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 7/02 (20130101) A61N 2007/006 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/50 (20130101) G01R 33/4814 (20130101) G01R 33/5602 (20130101) G01R 33/56341 (20130101) G01R 33/56358 (20130101)
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11224371 — Neural interface probe employing amorphous silicon carbide

US 11224371	Gardner et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	Board of Regents, The University of Texas System (Austin, Texas); Trustees of Boston University (Boston, Massachusetts)
ASSIGNEE(S)	Board of Regents, The University of Texas System (Austin, Texas); Trustees of Boston University (Boston, Massachusetts)
INVENTOR(S)	Timothy James Gardner (Brookline, Massachusetts); Stuart F. Cogan (Dallas, Texas)
ABSTRACT	A neural interface device that comprises an implantable microelectrode body. The implantable microelectrode body includes a neural interface probe, which includes a thin film metal trace connected to an interface pad and an amorphous silicon carbide insulation. The amorphous silicon carbide insulation surrounds the thin film metal trace to form an outside surface of the neural interface probe. The interface pad is exposed to an ambient environment of the neural interface probe through an opening in the amorphous silicon carbide insulation. Methods of manufacturing the neural interface device are disclosed.
FILED	Friday, June 22, 2018
APPL NO	16/015878
ART UNIT	3794 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/24 (20210101) Original (OR) Class A61B 5/291 (20210101) A61B 5/6868 (20130101) A61B 2562/043 (20130101) A61B 2562/125 (20130101) A61B 2562/0209 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 31/06 (20130101) A61L 31/10 (20130101) A61L 31/10 (20130101) A61L 31/14 (20130101) A61L 31/022 (20130101) A61L 31/028 (20130101) A61L 31/088 (20130101) Compositions of Macromolecular Compounds C08L 79/08 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/50 (20130101) C23C 16/56 (20130101) C23C 16/325 (20130101) C23C 28/00 (20130101) C23C 28/32 (20130101) C23C 28/341 (20130101)
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11224389 — Radiation transmission grid apparatus and methods for x-ray imaging detectors

US 11224389	Altunbas
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The Regents of the University of Colorado, a body corporate (Denver, Colorado)
ASSIGNEE(S)	The Regents of the University of Colorado, a body corporate (Denver, Colorado)
INVENTOR(S)	Cem Altunbas (Denver, Colorado)
ABSTRACT	The present invention relates generally to X-ray detectors and more particularly to a system and a method for integrating an anti-scattering grid with scintillators to significantly enhance the performance of flat panel X-ray detector. In particular, the performance of a flat panel X-ray detector may be enhanced by photon counting detector pixels configured underneath the septa of a 2D antiscatter grid.
FILED	Friday, April 13, 2018
APPL NO	16/606141
ART UNIT	2884 — Optics
CURRENT CPC	Diagnosis; Surgery; Identification A61B 6/4035 (20130101) A61B 6/4216 (20130101) A61B 6/4283 (20130101) A61B 6/4291 (20130101) Original (OR) Class Measurement of Nuclear or X-radiation G01T 1/2002 (20130101) G01T 1/2006 (20130101) G01T 7/00 (20130101)
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11224409 — Shear wave group velocity estimation using spatiotemporal peaks and amplitude thresholding

US 11224409	Greenleaf et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	Mayo Foundation for Medical Education and Research (Rochester, Minnesota)
ASSIGNEE(S)	Mayo Foundation for Medical Education and Research (Rochester, Minnesota)
INVENTOR(S)	James F. Greenleaf (Rochester, Minnesota); Carolina Amador Carrascal (Rochester, Minnesota); Shigao Chen (Rochester, Minnesota); Matthew W. Urban (Rochester, Minnesota); Armando Manduca (Rochester, Minnesota)
ABSTRACT	Described here are systems and methods for estimating shear wave velocity from data acquired with a shear wave elastography system. More particularly, the systems and methods described here implement a spatiotemporal time-to-peak algorithm that searches for the times at which shear wave motion is at a maximum while also searching for the lateral locations at which shear wave motion is at a maximum. Motion can include displacement, velocity, or acceleration caused by propagating shear waves. A fitting procedure (e.g., a linear fit) is performed on a combined set of these temporal peaks and spatial peaks to estimate the shear wave velocity, from which mechanical properties can be computed. Motion amplitude thresholding can also be used to increase the number of points for the fitting.
FILED	Tuesday, March 14, 2017
APPL NO	16/085248
ART UNIT	3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 8/463 (20130101) A61B 8/485 (20130101) Original (OR) Class A61B 8/5207 (20130101) A61B 8/5223 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/52042 (20130101)
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11224509 — Prosthetic heart valve with tri-leaflet design for use in percutaneous valve replacement procedures

US 11224509	Dasi et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	Ohio State Innovation Foundation (Columbus, Ohio); Lakshmi Prasad Dasi (Dublin, Ohio); Atieh Yousefi Koupaei (Columbus, Ohio); Megan Kristine Heitkemper (Columbus, Ohio)
ASSIGNEE(S)	Ohio State Innovation Foundation (Columbus, Ohio)
INVENTOR(S)	Lakshmi Prasad Dasi (Dublin, Ohio); Atieh Yousefi Koupaei (Columbus, Ohio); Megan Kristine Heitkemper (Columbus, Ohio)
ABSTRACT	A transcatheter prosthetic heart valve includes a stent frame and at least one sheet of leaflet material formed in to a tube, which includes a lower portion disposed on an exterior of the stent frame and an upper edge portion disposed within the stent frame. The upper edge portion includes at least a portion configured to wrap around a first portion of the top edge of the stent frame and fold towards an exterior of the stent frame. The upper edge portion also includes at least another portion configured to weave through the stent frame and fold towards the interior of the stent frame.
FILED	Friday, June 29, 2018
APPL NO	16/625456
ART UNIT	3774 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies
CURRENT CPC	Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/2415 (20130101) A61F 2/2418 (20130101) Original (OR) Class A61F 2/2433 (20130101) A61F 2210/0004 (20130101) A61F 2240/001 (20130101)
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11224573 — Therapeutic constructs for co-delivery of mitotic kinase inhibitor and immune checkpoint inhibitor

US 11224573	Yantasee et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Oregon Health and Science University (Portland, Oregon); PDX Pharmaceuticals, Inc. (Portland, Oregon)
ASSIGNEE(S)	Oregon Health and Science University (Portland, Oregon); PDX Pharmaceuticals, Inc. (Portland, Oregon)
INVENTOR(S)	Wassana Yantasee (Lake Oswego, Oregon); Moataz Reda (Portland, Oregon); Worapol Ngamcherdtrakul (Portland, Oregon)
ABSTRACT	Disclosed herein are therapeutic constructs including a delivery particle, at least one mitotic kinase inhibitor, and at least one immune checkpoint inhibitor. Also disclosed are therapeutic constructs including a mitotic kinase inhibitor, an immune checkpoint inhibitor, and a chemical linker. These therapeutic constructs cause cancer death by both therapeutic and immune effects and promote targeted delivery of more therapeutics to the surviving cancer cells in a positive feed-back loop. They enhance therapeutic index of free drugs and can be used intratumorally or systemically. This strategy can treat broad cancer types and is particular useful for cancer without obvious receptors for cancer-targeted delivery of otherwise toxic therapeutics.
FILED	Wednesday, September 16, 2020
APPL NO	17/023311
ART UNIT	1611 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/143 (20130101) Original (OR) Class A61K 9/146 (20130101) A61K 31/519 (20130101) A61K 47/6803 (20170801) A61K 47/6849 (20170801) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Peptides C07K 16/2827 (20130101)
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11224577 — Treating infection by a platelet-targeting microbe using nanoparticles

US 11224577	Zhang et al.
FUNDED BY	Department of Defense (DOD) Defense Threat Reduction Agency (DTRA) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Liangfang Zhang (San Diego, California); Che-Ming Jack Hu (Novato, California); Ronnie H. Fang (San Diego, California); Brian T. Luk (San Diego, California); Soracha Kun Thamphiwatana (San Diego, California)
ABSTRACT	The present invention relates to prevention and/or treatment of infection by a platelet-targeting microbe in a subject. The present invention provides for methods, combinations and pharmaceutical compositions for preventing and/or treating (and/or related uses) infection by a platelet-targeting microbe in a subject, using, inter alia, an effective amount of a nanoparticle comprising a) an inner core comprising a non-cellular material, b) an outer surface comprising a cellular membrane derived from a platelet; and optionally c) an agent for preventing said infection, treating said infection, diagnosing said infection, prognosing said infection and/or monitoring prevention or treatment of said infection. Exemplary platelet-targeting infections include infections by a bacterium, a virus, a fungus and/or a parasite.
FILED	Tuesday, June 07, 2016
APPL NO	15/737594
ART UNIT	1617 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/51 (20130101) Original (OR) Class A61K 9/5068 (20130101) A61K 9/5084 (20130101) A61K 9/5094 (20130101) A61K 31/337 (20130101) A61K 31/7042 (20130101) A61K 45/06 (20130101) A61K 47/6901 (20170801) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101)
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11224583 — Use of an RXR agonist in treating HER2+ cancers

US 11224583	Sanders et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Io Therapeutics, Inc. (Houston, Texas); Board of Regents, The University of Texas System (Austin, Texas)
ASSIGNEE(S)	Io Therapeutics, Inc. (Spring, Texas)
INVENTOR(S)	Martin E. Sanders (Seattle, Washington); Powel H. Brown (Houston, Texas)
ABSTRACT	The present specification provides combinations of active agents for the improved treatment of Her2⁺ cancers and associated methods of treatments. The combinations comprise and RXR agonist and a Her2-targeted therapeutic agent and may optionally further comprise thyroid hormone.
FILED	Friday, December 18, 2020
APPL NO	17/126347
ART UNIT	1627 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/185 (20130101) A61K 31/216 (20130101) Original (OR) Class A61K 31/517 (20130101) A61K 31/4709 (20130101) A61K 38/24 (20130101) A61K 39/3955 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101)
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11224609 — Mithramycin derivatives having increased selectivity and anti-cancer activity

US 11224609	Rohr et al.
FUNDED BY	Department of Defense (DOD) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	University of Kentucky Research Foundation (Lexington, Kentucky)
ASSIGNEE(S)	University of Kentucky Research Foundation (Lexington, Kentucky)
INVENTOR(S)	Jurgen Rohr (Lexington, Kentucky); Oleg Tsodikov (Lexington, Kentucky); Markos Leggas (Lexington, Kentucky); Caixia Hou (Lexington, Kentucky); Joseph Eckenrode (Lexington, Tennessee); Prithiba Mitra (Lexington, Kentucky); Abhisek Mandal (Lexington, Kentucky)
ABSTRACT	Mithramycin side chain carboxylic acid (MTM-SA) derivative are provided, which include a substituted amino acid derivative, a substituted amino acid dipeptide derivative, or an unsubstituted dipeptide derivative. The MTM-SA derivatives are useful for treatment of cancer or neuro-diseases associated with an aberrant erythroblast transformation-specific transcription factor. Unique MTM-SA derivatives have increased selectively toward ETS transcription factor.
FILED	Wednesday, September 05, 2018
APPL NO	16/122655
ART UNIT	1623 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/704 (20130101) A61K 31/7056 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101)
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11224624 — Modulation of microbial synthesis of 4-etylphenol and 4-ethylphenyl sulfate in behavior and disease

US 11224624	Needham et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) National Institute of General Medical Sciences (NIGMS) National Institute of Mental Health (NIMH)
APPLICANT(S)	California Institute of Technology (Pasadena, California); The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Brittany D. Needham (Pasadena, California); Sarkis K. Mazmanian (Pasadena, California); Gil Sharon (Pasadena, California); Masanori Funabashi (San Francisco, California); Michael A. Fischbach (San Francisco, California); Elaine Y. Hsiao (Pasadena, California); Paul H. Patterson (Pasadena, California)
ABSTRACT	Some embodiments relate to genetically engineered bacterial strains for modulation of levels of the bacterial metabolite 4-ethylphenol (4EP) and its sulfated form, 4-ethylphenyl sulfate (4EPS). In some embodiments, the bacteria reduce or inhibit production of 4EP or 4EPS in the gut of a subject. The bacteria can ameliorate, delay the onset or reduce the likelihood of one or more symptoms associated with anxiety and/or autism spectrum disorder (ASD) in the subject.
FILED	Tuesday, February 13, 2018
APPL NO	16/485403
ART UNIT	1655 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 33/135 (20160801) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0031 (20130101) A61K 9/0053 (20130101) A61K 35/747 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/22 (20180101)
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11224646 — Intranasal delivery of a cyclic-di-nucleotide adjuvanted vaccine for tuberculosis

US 11224646	Stanley et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Sarah Stanley (Berkeley, California); Erik Van Dis (Berkeley, California); Kimberly Sogi (Berkeley, California); Daniel A. Portnoy (Berkeley, California); Chris Rae (Berkeley, California)
ABSTRACT	A vaccine against Mycobacterium tuberculosis (M. tuberculosis) formulated for intranasal administration, comprises a first vaccine component comprising one or more M. tuberculosis, Mycobacterium vaccae (M. vaccae) or Mycobacteroium bovis (M. bovis) antigens, and a second vaccine component comprising a Stimulator of Interferon Genes (STING) activator.
FILED	Tuesday, July 07, 2020
APPL NO	16/921959
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/04 (20130101) Original (OR) Class A61K 2039/53 (20130101) A61K 2039/543 (20130101) A61K 2039/545 (20130101) A61K 2039/5256 (20130101) A61K 2039/55505 (20130101) A61K 2039/55511 (20130101) A61K 2039/55561 (20130101) A61K 2039/55566 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/06 (20180101)
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11224647 — Safe potent single platform vaccine against Tier 1 select agents and other pathogens

US 11224647	Horwitz et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Marcus A. Horwitz (Los Angeles, California); Qingmei Jia (Los Angeles, California)
ABSTRACT	A method of immunizing a susceptible host against a pathogen comprising administering to the host a vaccine that comprises an attenuated recombinant live vaccine strain lacking a polynucleotide encoding CapB (LVS ΔcapB), wherein the LVS ΔcapB expresses an antigen of at least one pathogen from Table 1; or administering to the host a vaccine that comprises an attenuated Listeria monocytogenes expressing the antigen of the pathogen from Table 1; or administering to the host a prime vaccine and a heterologous booster vaccine where the prime vaccine comprises an attenuated recombinant live vaccine strain lacking a polynucleotide encoding CapB (LVS ΔcapB), wherein the LVS ΔcapB expresses an antigen of at least one pathogen from Table 1 and the heterologous booster vaccine comprises an attenuated Listeria monocytogenes expressing the antigen of the pathogen from Table 1.
FILED	Monday, July 31, 2017
APPL NO	16/319812
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0043 (20130101) A61K 9/0053 (20130101) A61K 39/02 (20130101) A61K 39/04 (20130101) A61K 39/07 (20130101) A61K 39/114 (20130101) Original (OR) Class A61K 39/235 (20130101) A61K 39/0291 (20130101) A61K 2039/522 (20130101) A61K 2039/523 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/04 (20180101) Peptides C07K 14/20 (20130101) C07K 14/32 (20130101) C07K 14/36 (20130101) C07K 14/195 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 1/36 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101)
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11224648 — Antigen-adjuvant coupling reagents and methods of use

US 11224648	Irvine et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts); The Scripps Research Institute (La Jolla, California)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts); The Scripps Research Institute (La Jolla, California)
INVENTOR(S)	Darrell J. Irvine (Arlington, Massachusetts); Tyson Moyer (Boston, Massachusetts); William R. Schief (Encinitas, California)
ABSTRACT	The present disclosure relates to compositions and methods for coupling an antigen to an adjuvant, immunogenic compositions and vaccines. The methods of the invention can be used to increase an immune response, or to treat cancer or an infectious disease.
FILED	Wednesday, December 19, 2018
APPL NO	16/226376
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class A61K 39/39 (20130101) A61K 2039/70 (20130101) A61K 2039/55505 (20130101) A61K 2039/55555 (20130101)
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11224656 — Scintillator nanocrystal-containing compositions and methods for their use

US 11224656	Makale et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Milan T. Makale (San Diego, California); Wolfgang J. Wrasidlo (La Jolla, California); Santosh Kesari (La Jolla, California); Joanna McKittrick (La Jolla, California); Gustavo A. Hirata Flores (Ensenada, Mexico); Olivia Graeve (La Mesa, California)
ABSTRACT	There are provided, inter alia, compositions including a scintillator nanocrystal linked to a chemical agent moiety through a scintillator-activated photocleavable linker, and methods of use thereof.
FILED	Monday, November 16, 2020
APPL NO	17/099663
ART UNIT	1615 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/704 (20130101) A61K 41/0042 (20130101) Original (OR) Class A61K 47/6923 (20170801) A61K 47/6929 (20170801) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/06 (20130101) A61N 5/10 (20130101) A61N 2005/0661 (20130101) A61N 2005/1098 (20130101)
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11224662 — Methods and therapeutics comprising ligand-targeted ELPs

US 11224662	Hamm-Alvarez et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Eye Institute (NEI)
APPLICANT(S)	University of Southern California (Los Angeles, California)
ASSIGNEE(S)	UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California)
INVENTOR(S)	Sarah Hamm-Alvarez (Pasadena, California); John Andrew MacKay (Pasadena, California); Guoyong Sun (Mission Viejo, California); Pang-Yu Hsueh (San Jose, California)
ABSTRACT	Disclosed herein are novel methods and compositions for targeting drug delivery systems to specific cells. One aspect relates to a drug delivery system comprising an elastin-like peptide (ELP) component and a ligand selected from the group consisting of an polymeric immunoglobulin receptor binding site in the Cα3 domain of dimeric human IgA (mIgA) and knob capable of either drug encapsulation or drug attachment. Further aspects relate to drug delivery systems comprising an elastin-like peptide (ELP) component and a ligand; wherein the ligand specifically binds to a receptor selected from the group consisting of coxsackievirus and adenovirus receptor (CAR) and polymeric immunoglobulin receptor (pIgR). Further aspects include the novel transcytosing properties of the elastin-like peptide and the ligand, knob. Also provided are methods and pharmaceutical compositions comprising the disclosed therapeutics.
FILED	Friday, December 21, 2018
APPL NO	16/230698
ART UNIT	1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 47/6435 (20170801) Original (OR) Class A61K 49/0043 (20130101) A61K 49/0056 (20130101) Peptides C07K 14/001 (20130101) C07K 14/005 (20130101) C07K 16/28 (20130101) C07K 16/283 (20130101) C07K 2319/33 (20130101) C07K 2319/74 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2710/10033 (20130101)
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11224665 — Mitochondrial antiviral signaling (MAVS) protein compositions and methods of using the same

US 11224665	Lyerly et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Duke University (Durham, North Carolina)
ASSIGNEE(S)	Duke University (Durham, North Carolina)
INVENTOR(S)	Herbert K. Lyerly (Durham, North Carolina); Zachary C. Hartman (Durham, North Carolina)
ABSTRACT	The invention generally relates to compositions and methods for preventing and treating cancer. More specifically, the invention relates to MAVS compositions and their use in cancer therapeutics that may be used to treat various cancers alone or in combination with other anti-cancer therapeutic agents.
FILED	Thursday, October 05, 2017
APPL NO	15/726099
ART UNIT	1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) A61K 48/005 (20130101) Original (OR) Class Peptides C07K 14/47 (20130101) C07K 14/82 (20130101) C07K 14/4702 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2710/10343 (20130101)
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11224679 — Methods and compositions for dental tissue repair and/or regeneration

US 11224679	Celiz et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Dental and Craniofacial Research (NIDCR)
APPLICANT(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S)	Adam D. Celiz (Dorchester, Massachusetts); Kyle Holmberg Vining (Brookline, Massachusetts); David J. Mooney (Sudbury, Massachusetts)
ABSTRACT	The present invention provides methods and compositions for promoting dental tissue repair and/or regeneration, methods for promoting differentiation of dental pulp stem cells, methods for treating periodontal diseases, and methods for treating infection of a dental pulp in a subject in need thereof by contacting the tissue with a composition comprising a triacrylate capable of promoting dental pulp stem cells adhesion and/or proliferation.
FILED	Wednesday, March 08, 2017
APPL NO	16/082808
ART UNIT	1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Dentistry; Apparatus or Methods for Oral or Dental Hygiene A61C 5/00 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 6/54 (20200101) A61K 6/54 (20200101) A61K 31/27 (20130101) A61K 31/215 (20130101) A61K 31/225 (20130101) A61K 35/32 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/16 (20130101) A61L 27/16 (20130101) A61L 27/52 (20130101) A61L 27/3834 (20130101) Original (OR) Class A61L 2430/12 (20130101) Compositions of Macromolecular Compounds C08L 5/00 (20130101) C08L 33/08 (20130101) C08L 33/10 (20130101) C08L 33/10 (20130101) C08L 67/04 (20130101) C08L 2203/02 (20130101)
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11224746 — Method and apparatus to provide safety checks for neural stimulation

US 11224746	Greenberg et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI)
APPLICANT(S)	Second Sight Medical Products, Inc. (Sylmar, California)
ASSIGNEE(S)	Second Sight Medical Products, Inc. (Sylmar, California)
INVENTOR(S)	Robert Jay Greenberg (Los Angeles, California); Kelly Hobart McClure (Simi Valley, California); James S. Little (Arvada, Colorado); Rongqing Dai (Valencia, California); Arup Roy (Los Angeles, California); Richard Agustin Castro (Santa Monica, California); John Reinhold (Tarzana, California); Kea-Tiong Tang (Hsinchu, Taiwan); Sumit Yadav (Lake Forest, California); Chunhong Zhou (San Diego, California); David Daomin Zhou (Valencia, California); Pishoy Maksy (Newport Beach, California)
ABSTRACT	In electrically stimulating neural tissue it is important to prevent over stimulation and unbalanced stimulation, which would cause damage to the neural tissue, the electrode, or both. It is critical that neural tissue is not subjected to any direct current or alternating current above a safe threshold. Further, it is important to identify defective electrodes, as continued use may result in neural damage and further electrode damage. The present invention presents system and stimulator control mechanisms to prevent damage to neural tissue.
FILED	Thursday, July 18, 2019
APPL NO	16/516066
ART UNIT	3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/00 (20130101) A61N 1/08 (20130101) A61N 1/0543 (20130101) A61N 1/0551 (20130101) A61N 1/3603 (20170801) A61N 1/36046 (20130101) Original (OR) Class A61N 1/36142 (20130101) A61N 1/36185 (20130101)
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11225469 — Inhibitors of phosphoglycerate dehydrogenase (PHGDH) and uses thereof

US 11225469	Sabatini et al.
FUNDED BY	Department of Defense (DOD) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Drug Abuse (NIDA)
APPLICANT(S)	Whitehead Institute for Biomedical Research (Cambridge, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts); The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
ASSIGNEE(S)	Whitehead Institute for Biomedical Research (Cambridge, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts); The United States of America, as represented by the Secretary, Department of Health and Human Services (Silver Spring, Maryland)
INVENTOR(S)	David M. Sabatini (Cambridge, Massachusetts); Michael Pacold (Cambridge, Massachusetts); Matthew B. Boxer (New Market, Maryland); Jason M. Rohde (Poolesville, Maryland); Kyle R. Brimacombe (Highland, New York); Min Shen (Boyds, Maryland); Ganesha Bantukallu (Falls Church, Virginia); Li Liu (Germantown, Maryland)
ABSTRACT	The present invention provides compounds of Formula (II), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, pro-drugs, and compositions thereof. Also provided are methods and kits involving the compounds of Formula (I), (II) or (III) for treating diseases associated with the over-expression of phosphoglycerate dehydrogenase (PHGDH) in a subject, such as proliferative diseases (e.g., cancers (e.g., breast cancer, ER negative breast cancer, melanoma, cervical cancer), benign neoplasms, diseases associated with angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases). Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the activity of PHGDH or inhibit the serine biosynthetic pathway, or both.
FILED	Friday, January 15, 2016
APPL NO	15/543643
ART UNIT	1624 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 43/00 (20180101) Heterocyclic Compounds C07D 213/40 (20130101) C07D 213/75 (20130101) C07D 213/78 (20130101) C07D 231/40 (20130101) C07D 233/88 (20130101) C07D 235/30 (20130101) C07D 249/14 (20130101) C07D 401/12 (20130101) Original (OR) Class
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11225475 — Substituted pyridines as inhibitors of histone deacetylase

US 11225475	Fuller et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Aging (NIA) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Alkermes, Inc. (Waltham, Massachusetts)
ASSIGNEE(S)	Alkermes, Inc. (Waltham, Massachusetts)
INVENTOR(S)	Nathan Oliver Fuller (Arlington, Massachusetts); John A. Lowe, III (Stonington, Connecticut)
ABSTRACT	Provided herein are compounds and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of conditions associated with inhibition of HDAC (e.g., HDAC2).
FILED	Tuesday, August 07, 2018
APPL NO	16/636969
ART UNIT	1624 — Organic Chemistry
CURRENT CPC	Heterocyclic Compounds C07D 471/04 (20130101) Original (OR) Class C07D 487/04 (20130101) C07D 513/04 (20130101)
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11225479 — Bicyclic inhibitors of histone deacetylase

US 11225479	Fuller et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Aging (NIA) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Alkermes, Inc. (Waltham, Massachusetts)
ASSIGNEE(S)	Alkermes, Inc. (Waltham, Massachusetts)
INVENTOR(S)	Nathan Oliver Fuller (Arlington, Massachusetts); John A. Lowe, III (Stonington, Connecticut)
ABSTRACT	Provided herein are compounds and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of conditions associated with inhibition of HDAC (e.g., HDAC2).
FILED	Monday, August 31, 2020
APPL NO	17/007151
ART UNIT	1699 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/437 (20130101) A61K 31/519 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Heterocyclic Compounds C07D 471/04 (20130101) Original (OR) Class C07D 487/04 (20130101)
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11225487 — 7-membered aza-heterocyclic containing δ-opioid receptor modulating compounds, methods of using and making the same

US 11225487	Speerschneider et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	Trevena, Inc. (Chesterbrook, Pennsylvania)
ASSIGNEE(S)	Trevena, Inc. (Chesterbrook, Pennsylvania)
INVENTOR(S)	Aimee Crombie Speerschneider (Chesterbrook, Pennsylvania); Dennis Shinji Yamashita (Chesterbrook, Pennsylvania); Philip Michael Pitis (Chesterbrook, Pennsylvania); Michael John Hawkins (Chesterbrook, Pennsylvania); Guodong Liu (Chesterbrook, Pennsylvania); Tamara Ann Miskowski Daubert (Chesterbrook, Pennsylvania); Catherine C. K. Yuan (Chesterbrook, Pennsylvania); Robert Borbo Kargbo (Chesterbrook, Pennsylvania); Robert Jason Herr (Chesterbrook, Pennsylvania); Donna Romero (Chesterbrook, Pennsylvania)
ABSTRACT	The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.
FILED	Thursday, February 15, 2018
APPL NO	16/486539
ART UNIT	1625 — Organic Chemistry
CURRENT CPC	Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 23/00 (20180101) A61P 25/22 (20180101) A61P 25/24 (20180101) Heterocyclic Compounds C07D 223/04 (20130101) C07D 403/12 (20130101) C07D 403/14 (20130101) C07D 405/14 (20130101) C07D 417/14 (20130101) C07D 487/08 (20130101) Original (OR) Class
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11225496 — Chelated PSMA inhibitors

US 11225496	Berkman et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Cancer Targeted Technology LLC (Woodinville, Washington)
ASSIGNEE(S)	Cancer Targeted Technology LLC (Woodinville, Washington)
INVENTOR(S)	Clifford Berkman (Pullman, Washington); Cindy Choy (Pullman, Washington)
ABSTRACT	Provided herein are compounds of Formula (I) or a pharmaceutically acceptable salt thereof. Also provided are compositions including a compound of Formula (I) together with a pharmaceutically acceptable carrier, and methods for imaging prostate cancer cells.
FILED	Thursday, August 10, 2017
APPL NO	16/316567
ART UNIT	1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 51/048 (20130101) A61K 51/0406 (20130101) A61K 51/0478 (20130101) A61K 51/0485 (20130101) A61K 51/0489 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/24 (20130101) C07F 9/5532 (20130101) C07F 9/6524 (20130101) C07F 9/6561 (20130101) Original (OR) Class
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11225505 — Antimicrobial polymyxin derivative compounds

US 11225505	Roberts et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	MONASH UNIVERSITY (Clayton, Australia)
ASSIGNEE(S)	Monash University (Clayton, Australia)
INVENTOR(S)	Kade D. Roberts (Doubleview, Australia); Jian Li (Carnegie, Australia); Tony Velkov (Clarinda, Australia); Roger L. Nation (Ivanhoe East, Australia); Philip E. Thompson (Northcote, Australia)
ABSTRACT	The present invention relates to antimicrobial polymyxin derivative compounds and their uses, and in particular to peptide polymyxin antibiotics which may be used in the treatment of bacterial infections such as Gram negative bacterial infections, particularly those caused by multidrug-resistant (MDR) Gram negative bacterial infections.
FILED	Thursday, September 29, 2016
APPL NO	15/763954
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/12 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 7/62 (20130101) Original (OR) Class
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11225506 — Cell penetrating peptides and methods of making and using thereof

US 11225506	Pei et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Entrada Therapeutics, Inc. (Boston, Massachusetts)
ASSIGNEE(S)	Entrada Therapeutics, Inc. (Boston, Massachusetts)
INVENTOR(S)	Dehua Pei (Columbus, Ohio); Ziqing Qian (Boston, Massachusetts)
ABSTRACT	Disclosed herein are compounds having activity as cell penetrating peptides. In some examples, the compounds can comprise a cell penetrating peptide moiety and a cargo moiety. The cargo moiety can comprise one or more detectable moieties, one or more therapeutic moieties, one or more targeting moieties, or any combination thereof. In some examples, the cell penetrating peptide moiety is cyclic. In some examples, the cell penetrating peptide moiety and cargo moiety together are cyclic. In some examples, the cell penetrating peptide moiety is cyclic and the cargo moiety is appended to the cyclic cell penetrating peptide moiety structure. In some examples, the cargo moiety is cyclic and the cell penetrating peptide moiety is cyclic, and together they form a fused bicyclic system.
FILED	Monday, April 20, 2020
APPL NO	16/852615
ART UNIT	1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/05 (20130101) A61K 38/12 (20130101) A61K 38/465 (20130101) A61K 47/64 (20170801) A61K 49/0039 (20130101) A61K 49/0041 (20130101) A61K 49/0043 (20130101) A61K 49/0047 (20130101) A61K 49/0056 (20130101) Peptides C07K 7/06 (20130101) C07K 7/64 (20130101) Original (OR) Class Enzymes C12Y 301/03048 (20130101)
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11225507 — Conformation switchable antimicrobial peptides and methods of using the same

US 11225507	Cheng et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
ASSIGNEE(S)	The Board of Trustees of the University of Illinois (Urbana, Illinois)
INVENTOR(S)	Jianjun Cheng (Champaign, Illinois); Lin-Feng Chen (Champaign, Illinois); Menghua Xiong (Guangzhou, China PRC); Yan Bao (Guangzhou, China PRC)
ABSTRACT	The disclosure provides a class of pH-sensitive, helix/random conformation switchable antimicrobial polypeptide (HRS-AMP) compositions as a single agent to selectively kill bacteria (e.g., H. pylori) under acidic condition in the stomach with diminished bacterial resistance compared to currently used antibiotics. Methods of treating bacterial infections in the stomach are also provided.
FILED	Thursday, January 25, 2018
APPL NO	16/480914
ART UNIT	1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 1/1072 (20130101) C07K 14/001 (20130101) Original (OR) Class
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11225508 — Mouse-adapted SARS-CoV-2 viruses and methods of use thereof

US 11225508	Baric et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (Chapel Hill, North Carolina)
ASSIGNEE(S)	The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina)
INVENTOR(S)	Ralph Baric (Haw River, North Carolina); Kenneth Harold Dinnon, III (Chapel Hill, North Carolina); Sarah Rebecca Leist (Carrboro, North Carolina)
ABSTRACT	This invention relates to SARS-CoV-2 viruses adapted with nanoluciferase reporter molecules and mouse-adapted SARS-CoV-2 viruses, compositions including the same and methods of use thereof.
FILED	Thursday, February 11, 2021
APPL NO	17/173617
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/215 (20130101) A61K 2039/53 (20130101) A61K 2039/5258 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2770/18022 (20130101) C12N 2770/18023 (20130101) C12N 2770/18034 (20130101) C12N 2770/18071 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101)
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11225511 — BH3 peptides and methods of use thereof

US 11225511	Korsmeyer et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts)
ASSIGNEE(S)	Howard Hughes Medical Institute (Chevy Chase, Maryland); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts)
INVENTOR(S)	Stanley J. Korsmeyer (Weston, Massachusetts); Anthony Letai (Medfield, Massachusetts)
ABSTRACT	The invention provides peptides and the nucleic acid sequences that encode them. The invention further provides therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of apoptosis associated disorders.
FILED	Friday, January 12, 2018
APPL NO	15/869537
ART UNIT	1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Peptides C07K 14/4747 (20130101) Original (OR) Class C07K 2319/03 (20130101)
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11225512 — Compositions and methods for ceramide-elevating therapeutic strategies

US 11225512	Barth
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	University of New Hampshire (Durham, New Hampshire)
ASSIGNEE(S)	University of New Hampshire (Durham, New Hampshire)
INVENTOR(S)	Brian Barth (Durham, New Hampshire)
ABSTRACT	The present invention is directed towards the use of Growth Differentiation Factor 1 (Gdf1) and variants thereof to modulate and regulate ceramide neutralization in cells.
FILED	Friday, April 27, 2018
APPL NO	15/965383
ART UNIT	1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/706 (20130101) A61K 31/706 (20130101) A61K 38/18 (20130101) A61K 38/1841 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Peptides C07K 14/475 (20130101) Original (OR) Class C07K 14/495 (20130101) C07K 2319/00 (20130101)
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11225514 — Nanobodies against cystic fibrosis transmembrane conductance regulator (CFTR) inhibitory factor (Cif)

US 11225514	Hammock et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) National Institute of Environmental Health Sciences (NIEHS)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire)
INVENTOR(S)	Bruce D. Hammock (Davis, California); Natalia Vasylieva (Davis, California); Jiexian Dong (Davis, California); Christophe Morisseau (West Sacramento, California); Dean R. Madden (Hanover, New Hampshire)
ABSTRACT	Provided are VHH or nanobodies that specifically bind to cystic fibrosis transmembrane conductance regulator (CFTR) inhibitory factor (Cif), and uses thereof for diagnosis and treatment of Pseudomonas infection.
FILED	Tuesday, May 29, 2018
APPL NO	16/616930
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Peptides C07K 16/40 (20130101) C07K 16/1214 (20130101) Original (OR) Class C07K 2317/22 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/569 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56911 (20130101) G01N 2333/21 (20130101)
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11225520 — Immunotherapy compositions and methods

US 11225520	Novina et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts)
ASSIGNEE(S)	DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts)
INVENTOR(S)	Carl Novina (Newton, Massachusetts); Robert Distel (Framingham, Massachusetts); Alberto Nobili (Brookline, Massachusetts)
ABSTRACT	The present invention provides universal immunotherapy compositions useful for targeted treatment of cancers and other immune disorders.
FILED	Thursday, February 16, 2017
APPL NO	16/077939
ART UNIT	1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 35/17 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 7/08 (20130101) C07K 16/32 (20130101) C07K 16/2809 (20130101) Original (OR) Class C07K 2317/622 (20130101) C07K 2319/03 (20130101) C07K 2319/33 (20130101) C07K 2319/50 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101)
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11225525 — Antibodies for botulinum neurotoxins

US 11225525	Marks et al.
FUNDED BY	Department of Defense (DOD) Defense Threat Reduction Agency (DTRA) Department of Health and Human Services (HHS) Centers for Disease Control and Prevention (CDC) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	James D. Marks (Kensington, California); Maria Consuelo Garcia Rodriguez (San Francisco, California)
ABSTRACT	The present disclosure provides antibodies that specifically bind to botulinum neurotoxins (e.g., BoNT/A, BoNT/B, BoNT/C, BoNT/D, BoNT/E, BoNT/F, BoNT/G, etc.) and the epitopes bound by those antibodies. The antibodies and derivatives thereof that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism.
FILED	Monday, March 09, 2020
APPL NO	16/813161
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) A61K 2039/507 (20130101) Peptides C07K 16/40 (20130101) Original (OR) Class C07K 16/1282 (20130101) C07K 2317/20 (20130101) C07K 2317/21 (20130101) C07K 2317/24 (20130101) C07K 2317/33 (20130101) C07K 2317/54 (20130101) C07K 2317/55 (20130101) C07K 2317/56 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/565 (20130101) C07K 2317/622 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/573 (20130101) G01N 33/56911 (20130101) G01N 2333/33 (20130101) G01N 2333/952 (20130101)
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11225651 — Treatment for airway cast obstruction

US 11225651	Veress et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Environmental Health Sciences (NIEHS)
APPLICANT(S)	NATIONAL JEWISH HEALTH (Denver, Colorado)
ASSIGNEE(S)	National Jewish Health (Denver, Colorado)
INVENTOR(S)	Livia A. Veress (Denver, Colorado); Carl W. White (Denver, Colorado)
ABSTRACT	The present invention is directed to methods of treatment of airway obstruction associated with fibrin-containing cast formation by administering a fibrinolytic agent.
FILED	Tuesday, July 30, 2019
APPL NO	16/526733
ART UNIT	1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0078 (20130101) A61K 38/49 (20130101) A61K 38/482 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/6459 (20130101) Original (OR) Class C12N 9/6462 (20130101) Enzymes C12Y 304/21068 (20130101) C12Y 304/21073 (20130101)
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11225653 — Methods and compounds for reducing threonyl-tRNA synthetase activity

US 11225653	Francklyn et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Environmental Health Sciences (NIEHS) National Research Service Award (NRSA) Institutional Research Training Grant (T32)
APPLICANT(S)	University of Vermont and State Agricultural College (Burlington, Vermont)
ASSIGNEE(S)	University of Vermont and State Agricultural College (Burlington, Vermont)
INVENTOR(S)	Christopher Francklyn (Burlington, Vermont); Karen M. Lounsbury (Essex Junction, Vermont); Jason Botten (Williston, Vermont)
ABSTRACT	The invention includes, in part, methods and compounds for treating diseases and conditions characterized by elevated threonyl-tRNA synthetase (TARS) activity, which include, but are not limited to diseases and conditions in which angiogenesis is elevated as compared to normal. In some embodiments of the invention, a level of a TARS molecule is determined and compared to a control level of TARS to assess a treatment for a disease or condition characterized by elevated TARS activity.
FILED	Tuesday, September 18, 2018
APPL NO	16/134481
ART UNIT	1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/7125 (20130101) A61K 38/53 (20130101) A61K 39/3955 (20130101) A61K 45/06 (20130101) Peptides C07K 16/40 (20130101) C07K 2317/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/99 (20130101) Original (OR) Class Enzymes C12Y 601/01003 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/502 (20130101) G01N 33/6893 (20130101) G01N 2333/9015 (20130101) G01N 2800/7014 (20130101)
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11225660 — Methods and compositions for managing vascular conditions using miR-483 mimics and HIF1alpha pathway inhibitors

US 11225660	Jo et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	Emory University (Atlanta, Georgia)
ASSIGNEE(S)	Emory University (Atlanta, Georgia)
INVENTOR(S)	Hanjoong Jo (Atlanta, Georgia); Joan Fernandez Esmerats (Atlanta, Georgia); Nicolas Villa-Roel (Brookhaven, Georgia)
ABSTRACT	This disclosure relates to the use of miRNA-483 and its target genes, UBE2C, pVHL and HIF1alpha, in managing the treatment of cardiovascular and inflammatory diseases. In certain embodiments, this disclosure relates to pharmaceutical compositions comprising a miR-483 mimic and/or an HIF inhibitor and a pharmaceutically acceptable excipient for use in treating or preventing a vascular disease or condition. In certain embodiments, the miR-483 mimic is a double stranded nucleobase polymer or an expression vector that expresses mature human miR-483-5p and miR-483-3p sequences or operable fragments and variants.
FILED	Wednesday, October 10, 2018
APPL NO	16/156917
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/198 (20130101) A61K 31/198 (20130101) A61K 31/713 (20130101) A61K 31/713 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/113 (20130101) C12N 2310/141 (20130101) C12N 2310/3231 (20130101) C12N 2320/31 (20130101)
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11225663 — Methods to detect motor neuron disease comprising micro-RNAs

US 11225663	Miller et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	Washington University (St. Louis, Missouri)
ASSIGNEE(S)	Washington University (St. Louis, Missouri)
INVENTOR(S)	Timothy M. Miller (St. Louis, Missouri); Mariah Lawler Hoye (St. Louis, Missouri); Ted Hyman (St. Louis, Missouri); Erica Koval (St. Louis, Missouri); Joseph Dougherty (St. Louis, Missouri)
ABSTRACT	The present invention relates to compositions and methods for detecting motor neuron-specific miRNAs in a population of cells or subject. More particularly, the invention relates to detecting motor neuron-specific miRNAs to detect and treat motor neuron diseases associated with dysregulation of motor neuron-specific miRNAs, such as Amyotrophic Lateral Sclerosis (ALS).
FILED	Friday, October 11, 2019
APPL NO	16/600097
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/7105 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/141 (20130101) C12N 2320/10 (20130101) C12N 2320/30 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 2600/178 (20130101)
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11225665 — P38 map kinase inhibitors

US 11225665	Rossi et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	City of Hope (Duarte, California)
ASSIGNEE(S)	CITY OF HOPE (Duarte, California)
INVENTOR(S)	John J. Rossi (Monrovia, California); Sorah Yoon (Pasadena, California)
ABSTRACT	Provided herein, inter alia, are p38 mitogen-activated protein kinase inhibitors and methods of treating cancer using p38 mitogen-activated protein kinase inhibitors.
FILED	Monday, June 15, 2020
APPL NO	16/902029
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) Original (OR) Class
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11225666 — Plasmid vector for expressing a PVT1 exon and method for constructing standard curve therefor

US 11225666	Ogunwobi et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Minority Health and Health Disparities (NIMHD)
APPLICANT(S)	Research Foundation of the City University of New York (New York, New York)
ASSIGNEE(S)	Research Foundation of the City University of New York (New York, New York)
INVENTOR(S)	Olorunseun O. Ogunwobi (Yonkers, New York); Gargi Pal (New York, New York)
ABSTRACT	A method for cloning an exon into a plasmid vector. Exons related to prostate cancer (PVT1 exon 9, PVT1 exon 4A or PVT1 exon 4B) and miRNAs (miR-1205 or miR-1207-3p) are transformed into the plasmid vector. The cloned exons or miRNAs are linearized and their concentrations quantified. Serial dilutions in conjunction with spectroscopy permit the construction of a standard curve that permits absolute quantification of the exons or miRNAs in a biological sample from a patient.
FILED	Monday, March 18, 2019
APPL NO	16/356635
ART UNIT	1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/70 (20130101) Original (OR) Class C12N 15/113 (20130101) C12N 15/1135 (20130101) C12N 2310/141 (20130101) C12N 2800/101 (20130101)
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11225689 — Method for determination and identification of cell signatures and cell markers

US 11225689	Shekhar et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Mental Health (NIMH)
APPLICANT(S)	THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts)
ASSIGNEE(S)	The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S)	Karthik Shekhar (Cambridge, Massachusetts); Sylvain Lapan (Cambridge, Massachusetts); Irene Whitney (Cambridge, Massachusetts); Evan Macosko (Cambridge, Massachusetts); Steven McCarroll (Cambgridge, Massachusetts); Constance Cepko (Cambridge, Massachusetts); Aviv Regev (Cambridge, Massachusetts); Joshua Sanes (Cambridge, Massachusetts)
ABSTRACT	The present invention provides for methods of identifying cell types and cell subtypes from a biological sample or population of target cells. The methods further provide for determining cell type or cell subtype signatures. The method further provides for bipolar cell subtypes and markers and cell signatures thereof.
FILED	Thursday, August 17, 2017
APPL NO	15/680127
ART UNIT	1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0621 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6841 (20130101) C12Q 1/6881 (20130101) Original (OR) Class C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56966 (20130101) G01N 2800/164 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 25/00 (20190201) G16B 25/10 (20190201) G16B 40/00 (20190201) G16B 40/20 (20190201) G16B 40/30 (20190201)
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11225691 — Methods and materials for detecting SNPs and administering measles virus

US 11225691	Kennedy et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Mayo Foundation for Medical Education and Research (Rochester, Minnesota)
ASSIGNEE(S)	Mayo Foundation for Medical Education and Research (Rochester, Minnesota)
INVENTOR(S)	Richard B. Kennedy (Rochester, Minnesota); Gregory A. Poland (Marco Island, Florida); Inna G. Ovsyannikova (Rochester, Minnesota); Iana H. Haralambieva (Rochester, Minnesota)
ABSTRACT	This document provides methods and materials involved in using measles viruses. For example, methods and materials for identifying mammals (e.g., humans) likely to respond to standard measles virus vaccines or standard measles virus-based therapies as well as methods and materials for identifying mammals (e.g., humans) unlikely to respond to standard measles virus vaccines or standard measles virus-based therapies are provided.
FILED	Friday, June 12, 2020
APPL NO	16/900704
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/39 (20130101) A61K 39/165 (20130101) A61K 2039/572 (20130101) A61K 2039/575 (20130101) A61K 2039/55588 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/12 (20180101) A61P 31/14 (20180101) A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2760/18434 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/156 (20130101)
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11226336 — Compact and homogeneous quantum dots and methods of making the same

US 11226336	Smith et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Environmental Health Sciences (NIEHS) National Institute of Neurological Disorders and Stroke (NINDS) National Science Foundation (NSF)
APPLICANT(S)	The Board of Trustees of the University of Illinois (Urbana, Illinois)
ASSIGNEE(S)	THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
INVENTOR(S)	Andrew M. Smith (Savoy, Illinois); Chunlai Tu (Urbana, Illinois); Liang Ma (Urbana, Illinois)
ABSTRACT	The present disclosure provides quantum dots and methods of making the quantum dots comprising a substantially homogeneous population of monomeric nanocrystals, of a very small size, about 7 nm to about 12 nm in diameter. The method comprises mixing a nanocrystal coated with weakly binding ligands or ions with a polymer in a solution and incubating at a temperature greater than about 100° C., thereby forming a quantum dot having a substantially homogenous population of monomeric nanocrystals. The quantum dots can be further conjugated to bioaffinity molecules, enabling broad utilization of compact, biofunctional quantum dots for studying crowded macromolecular environments.
FILED	Tuesday, July 25, 2017
APPL NO	15/658485
ART UNIT	1641 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) B82Y 15/00 (20130101) B82Y 40/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 19/007 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/84 (20130101) C01P 2002/86 (20130101) C01P 2004/64 (20130101) Peptides C07K 2/00 (20130101) C07K 16/18 (20130101) C07K 2317/569 (20130101) C07K 2319/21 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/533 (20130101) G01N 33/587 (20130101) G01N 33/588 (20130101) Original (OR) Class G01N 33/54346 (20130101)
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11226383 — Actively shimmed needles and stylets for interventional MRI

US 11226383	Sengupta
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	Vanderbilt University (Nashville, Tennessee)
ASSIGNEE(S)	VANDERBILT UNIVERSITY (Nashville, Tennessee)
INVENTOR(S)	Saikat Tarun Sengupta (Nashville, Tennessee)
ABSTRACT	Artifacts caused by metallic needles used in MRI-guided procedures such as tumor biopsies significantly decrease the visibility of therapy targets and diminish the ability of the physician to accurately monitor and perform the procedure. As described in the present application, a needle including active shimming can self-compensate for these artifacts and significantly improve the visualization and monitoring of targeted tissue. The accuracy and overall outcomes of MRI-guided treatments can be significantly improved with the use of the needle.
FILED	Wednesday, May 06, 2020
APPL NO	16/868408
ART UNIT	2852 — Printing/Measuring and Testing
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/055 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/285 (20130101) Original (OR) Class G01R 33/3815 (20130101) G01R 33/3875 (20130101)
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11226474 — Reverberation microscopy systems and methods

US 11226474	Mertz et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC)
APPLICANT(S)	Trustees of Boston University (Boston, Massachusetts)
ASSIGNEE(S)	TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts)
INVENTOR(S)	Jerome Charles Mertz (Newton, Massachusetts); Devin Robert Beaulieu (Brookline, Massachusetts); Thomas Gary Bifano (Mansfield, Massachusetts)
ABSTRACT	A method for obtaining one or more images of a sample using a microscope includes dividing, using a reverberation cavity, a first one of a plurality of laser pulses into a plurality of sequential sub-pulses, each of the plurality of sequential sub-pulses having a power that is less than a previous one of the plurality of sequential sub-pulses, directing, using the one or more lenses of the microscope, the plurality of sequential sub-pulses onto a portion of the sample to generate a plurality of signals, each of the plurality of signals being associated with a different depth within the sample, and detecting the plurality of signals from the sample to generate one or more images of at least a portion of the sample.
FILED	Thursday, April 23, 2020
APPL NO	16/856941
ART UNIT	2886 — Optics
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6402 (20130101) G01N 21/6458 (20130101) G01N 2201/06113 (20130101) Optical Elements, Systems, or Apparatus G02B 21/0032 (20130101) Original (OR) Class G02B 21/0048 (20130101) G02B 21/0076 (20130101)
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11227142 — Culture imaging system

US 11227142	Robinson et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) Department of Agriculture (USDA)
APPLICANT(S)	Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S)	Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S)	Joseph Paul Robinson (West Lafayette, Indiana); Bartlomiej P. Rajwa (West Lafayette, Indiana); Kathryn E. Ragheb (West Lafayette, Indiana); Cheryl M. Holdman (Brookston, Indiana); Valery P. Patsekin (West Lafayette, Indiana); Euiwon Bae (West Lafayette, Indiana); Jennifer Sturgis (West Lafayette, Indiana)
ABSTRACT	A system for the characterization of a colony of microorganisms includes a coherent light source configured to provide coherent light of one or more wavelengths along a common optical path. A holder is configured to operationally arrange a substrate so that the colony of microorganisms on a surface of the substrate is positioned to receive the coherent light. Scattered light is generated from the colony of microorganisms receiving coherent light. A first image capture device is configured to receive the scattered light and generate a scatter image from the microorganism colony irradiated by the coherent light. The system also includes a magnifying lens configured to magnify the colony of microorganisms. A second image capture device is configured to capture a light image of the colony of microorganisms magnified by the magnifying lens. Methods of assigning organisms to categories with like organisms without necessarily identifying the organisms are also described.
FILED	Friday, June 12, 2020
APPL NO	16/900841
ART UNIT	2668 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Apparatus for Enzymology or Microbiology; C12M 41/36 (20130101) Optical Elements, Systems, or Apparatus G02B 21/365 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/0014 (20130101) G06K 9/00134 (20130101) G06K 9/00147 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/10056 (20130101) G06T 2207/30024 (20130101)
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11227403 — Anisotropic twicing for single particle reconstruction using autocorrelation analysis

US 11227403	Zhang et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	The Trustees of Princeton University (Princeton, New Jersey)
ASSIGNEE(S)	The Trustees of Princeton University (Princeton, New Jersey)
INVENTOR(S)	Teng Zhang (Oviedo, Florida); Amit Singer (New York, New York); Tejal Bhamre (Mountain View, California)
ABSTRACT	Methods and systems are described for digitally reconstructing an unknown 3D structure of a target molecule using orthogonal extension. A plurality of 2D images of the target molecule are captured by an imaging system. An estimated low-order moment of the unknown 3D structure (e.g., a covariance matrix) is calculated based on the 2D images. A homologous molecule having a known 3D structure is identified and at least one expansion coefficient of the known structure of the homologous molecule is determined. At least one estimated expansion coefficient for the unknown structure is calculated based at least in part on the estimated low order moment of the unknown structure and the at least one expansion coefficient of the known structure. An estimated 3D reconstruction of the target molecule is then generated based on the at least one estimated expansion coefficient for the unknown structure of the target molecule.
FILED	Tuesday, April 24, 2018
APPL NO	16/605987
ART UNIT	2645 — Telecommunications: Analog Radio Telephone; Satellite and Power Control; Transceivers, Measuring and Testing; Bluetooth; Receivers and Transmitters; Equipment Details
CURRENT CPC	Image Data Processing or Generation, in General G06T 7/55 (20170101) Original (OR) Class G06T 17/00 (20130101) G06T 2207/10061 (20130101) G06T 2207/20056 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/00 (20190201) Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 20/20 (20190201)
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11228547 — RNA targeting methods and compositions

US 11228547	Hsu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Aging (NIA) NIH Office of the Director (NIHOD)
APPLICANT(S)	Salk Institute for Biological Studies (La Jolla, California)
ASSIGNEE(S)	Salk Institute for Biological Studies (La Jolla, California)
INVENTOR(S)	Patrick D. Hsu (San Diego, California); Silvana Konermann (San Diego, California)
ABSTRACT	Provided herein are CRISPR/Cas methods and compositions for targeting RNA molecules, which can be used to detect, edit, or modify a target RNA.
FILED	Friday, January 25, 2019
APPL NO	16/257493
ART UNIT	1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/85 (20130101) C12N 15/102 (20130101) C12N 15/113 (20130101) C12N 15/8201 (20130101) C12N 15/8213 (20130101) C12N 2310/16 (20130101) C12N 2310/20 (20170501) C12N 2310/3519 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/08 (20130101) H04L 9/30 (20130101) H04L 45/745 (20130101) H04L 51/08 (20130101) H04L 51/12 (20130101) Original (OR) Class H04L 51/14 (20130101) H04L 51/18 (20130101)
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Department of Defense (DOD)

11224577 — Treating infection by a platelet-targeting microbe using nanoparticles

US 11224577	Zhang et al.
FUNDED BY	Department of Defense (DOD) Defense Threat Reduction Agency (DTRA) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Liangfang Zhang (San Diego, California); Che-Ming Jack Hu (Novato, California); Ronnie H. Fang (San Diego, California); Brian T. Luk (San Diego, California); Soracha Kun Thamphiwatana (San Diego, California)
ABSTRACT	The present invention relates to prevention and/or treatment of infection by a platelet-targeting microbe in a subject. The present invention provides for methods, combinations and pharmaceutical compositions for preventing and/or treating (and/or related uses) infection by a platelet-targeting microbe in a subject, using, inter alia, an effective amount of a nanoparticle comprising a) an inner core comprising a non-cellular material, b) an outer surface comprising a cellular membrane derived from a platelet; and optionally c) an agent for preventing said infection, treating said infection, diagnosing said infection, prognosing said infection and/or monitoring prevention or treatment of said infection. Exemplary platelet-targeting infections include infections by a bacterium, a virus, a fungus and/or a parasite.
FILED	Tuesday, June 07, 2016
APPL NO	15/737594
ART UNIT	1617 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/51 (20130101) Original (OR) Class A61K 9/5068 (20130101) A61K 9/5084 (20130101) A61K 9/5094 (20130101) A61K 31/337 (20130101) A61K 31/7042 (20130101) A61K 45/06 (20130101) A61K 47/6901 (20170801) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101)
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11224609 — Mithramycin derivatives having increased selectivity and anti-cancer activity

US 11224609	Rohr et al.
FUNDED BY	Department of Defense (DOD) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	University of Kentucky Research Foundation (Lexington, Kentucky)
ASSIGNEE(S)	University of Kentucky Research Foundation (Lexington, Kentucky)
INVENTOR(S)	Jurgen Rohr (Lexington, Kentucky); Oleg Tsodikov (Lexington, Kentucky); Markos Leggas (Lexington, Kentucky); Caixia Hou (Lexington, Kentucky); Joseph Eckenrode (Lexington, Tennessee); Prithiba Mitra (Lexington, Kentucky); Abhisek Mandal (Lexington, Kentucky)
ABSTRACT	Mithramycin side chain carboxylic acid (MTM-SA) derivative are provided, which include a substituted amino acid derivative, a substituted amino acid dipeptide derivative, or an unsubstituted dipeptide derivative. The MTM-SA derivatives are useful for treatment of cancer or neuro-diseases associated with an aberrant erythroblast transformation-specific transcription factor. Unique MTM-SA derivatives have increased selectively toward ETS transcription factor.
FILED	Wednesday, September 05, 2018
APPL NO	16/122655
ART UNIT	1623 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/704 (20130101) A61K 31/7056 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101)
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11224626 — Methods of identifying bacteriophages that can infect and kill host-adapted infectious pathogenic bacteria

US 11224626	Regeimbal et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Secretary of the Army (SECARMY) Department of the Navy (DON) Secretary of the Navy (SECNAV)
APPLICANT(S)	James M Regeimbal (Washington's Crossing, Pennsylvania); Stuart D Tyner (Great Falls, Virginia)
ASSIGNEE(S)	The United States of America as Represented by the Secretary of the Navy (Arlington, Virginia); The United States of America as Represented by the Secretary of the Army (Silver Spring, Maryland)
INVENTOR(S)	James M Regeimbal (Washington's Crossing, Pennsylvania); Stuart D Tyner (Great Falls, Virginia)
ABSTRACT	The subject matter of the instant invention relates to methods of enhancing harvesting of phages against a targeted host bacteria, as well as methods of identifying phages likely to have an enhanced propensity to infect and kill an infectious pathogenic bacteria in vivo, from samples comprising phages. The invention also relates to phage libraries, pharmaceutical compositions, methods of treatment, and phage-based diagnostic methods and methods of detecting bacteria related thereto.
FILED	Friday, August 24, 2018
APPL NO	16/112148
ART UNIT	1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/76 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2795/00032 (20130101) C12N 2795/00051 (20130101)
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11225469 — Inhibitors of phosphoglycerate dehydrogenase (PHGDH) and uses thereof

US 11225469	Sabatini et al.
FUNDED BY	Department of Defense (DOD) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Drug Abuse (NIDA)
APPLICANT(S)	Whitehead Institute for Biomedical Research (Cambridge, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts); The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
ASSIGNEE(S)	Whitehead Institute for Biomedical Research (Cambridge, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts); The United States of America, as represented by the Secretary, Department of Health and Human Services (Silver Spring, Maryland)
INVENTOR(S)	David M. Sabatini (Cambridge, Massachusetts); Michael Pacold (Cambridge, Massachusetts); Matthew B. Boxer (New Market, Maryland); Jason M. Rohde (Poolesville, Maryland); Kyle R. Brimacombe (Highland, New York); Min Shen (Boyds, Maryland); Ganesha Bantukallu (Falls Church, Virginia); Li Liu (Germantown, Maryland)
ABSTRACT	The present invention provides compounds of Formula (II), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, pro-drugs, and compositions thereof. Also provided are methods and kits involving the compounds of Formula (I), (II) or (III) for treating diseases associated with the over-expression of phosphoglycerate dehydrogenase (PHGDH) in a subject, such as proliferative diseases (e.g., cancers (e.g., breast cancer, ER negative breast cancer, melanoma, cervical cancer), benign neoplasms, diseases associated with angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases). Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the activity of PHGDH or inhibit the serine biosynthetic pathway, or both.
FILED	Friday, January 15, 2016
APPL NO	15/543643
ART UNIT	1624 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 43/00 (20180101) Heterocyclic Compounds C07D 213/40 (20130101) C07D 213/75 (20130101) C07D 213/78 (20130101) C07D 231/40 (20130101) C07D 233/88 (20130101) C07D 235/30 (20130101) C07D 249/14 (20130101) C07D 401/12 (20130101) Original (OR) Class
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11225525 — Antibodies for botulinum neurotoxins

US 11225525	Marks et al.
FUNDED BY	Department of Defense (DOD) Defense Threat Reduction Agency (DTRA) Department of Health and Human Services (HHS) Centers for Disease Control and Prevention (CDC) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	James D. Marks (Kensington, California); Maria Consuelo Garcia Rodriguez (San Francisco, California)
ABSTRACT	The present disclosure provides antibodies that specifically bind to botulinum neurotoxins (e.g., BoNT/A, BoNT/B, BoNT/C, BoNT/D, BoNT/E, BoNT/F, BoNT/G, etc.) and the epitopes bound by those antibodies. The antibodies and derivatives thereof that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism.
FILED	Monday, March 09, 2020
APPL NO	16/813161
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) A61K 2039/507 (20130101) Peptides C07K 16/40 (20130101) Original (OR) Class C07K 16/1282 (20130101) C07K 2317/20 (20130101) C07K 2317/21 (20130101) C07K 2317/24 (20130101) C07K 2317/33 (20130101) C07K 2317/54 (20130101) C07K 2317/55 (20130101) C07K 2317/56 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/565 (20130101) C07K 2317/622 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/573 (20130101) G01N 33/56911 (20130101) G01N 2333/33 (20130101) G01N 2333/952 (20130101)
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11225713 — Stable IR transparent conductive graphene hybrid materials and methods of making

US 11225713	Lock et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Secretary of the Navy (SECNAV)
APPLICANT(S)	The Government of the United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
ASSIGNEE(S)	The Government of the United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Evgeniya H. Lock (Alexandria, Virginia); Nicholas A. Charipar (Alexandria, Virginia); Alberto Piqué (Crofton, Maryland)
ABSTRACT	A method of making a transparent conductive graphene hybrid, comprising the steps of providing a PMMA/Graphene hybrid, functionalizing the PMMA/Graphene hybrid, providing a transparent substrate, oxidizing the transparent substrate, treating the oxidized substrate and forming a functionalized substrate, applying the PMMA/Graphene hybrid to the functionalized substrate, removing the PMMA, and forming a transparent conductive graphene hybrid. A transparent conductive graphene hybrid comprising a transparent substrate, wherein the transparent substrate is oxidized, and wherein the transparent substrate is treated with TFPA-NH2 to form a functionalized substrate, and a layer of graphene on the functionalized substrate.
FILED	Thursday, April 20, 2017
APPL NO	15/492728
ART UNIT	1783 — Miscellaneous Articles, Stock Material
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/01 (20130101) C23C 16/26 (20130101) Original (OR) Class C23C 16/56 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/04 (20130101) H01B 5/14 (20130101) H01B 13/0036 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/30 (20150115)
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11226195 — Method and system for measuring strain in a 3D printed part

US 11226195	Pankonien et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Secretary of the Air Force (SECAF)
APPLICANT(S)	Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
ASSIGNEE(S)	UNITED STATES OF AMERICA represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
INVENTOR(S)	Alexander Pankonien (Fairborn, Ohio); Joshua Deaton (Beavercreek, Ohio); Ryan Durscher (Loveland, Ohio)
ABSTRACT	A method and system for measuring strain in a 3D printed part is disclosed herein. The printed part can be formed with internal features that can be analyzed with a digital image correlation system to determine strain levels in internal regions of the part. The features are visually identifiable due to a different color, shape, design or other visually distinguishable characteristics relative to that of the base structural material. The features can be the formed from the same material or a different material from that of the base structure material.
FILED	Tuesday, May 07, 2019
APPL NO	16/404987
ART UNIT	2483 — Recording and Compression
CURRENT CPC	Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/386 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 50/00 (20141201) B33Y 80/00 (20141201) Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 11/16 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 7/001 (20130101) G06T 7/55 (20170101) G06T 7/74 (20170101) G06T 7/90 (20170101) G06T 2207/30144 (20130101) G06T 2207/30164 (20130101) Pictorial Communication, e.g Television H04N 5/2256 (20130101) H04N 5/23203 (20130101)
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11226378 — Electrical current connector

US 11226378	Podlesak et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Secretary of the Army (SECARMY)
APPLICANT(S)	The Government of the United States, as represented by the Secretary of the Army (Washington, District of Columbia)
ASSIGNEE(S)	The Government of the United States, as represented by the Secretary of the Army (Washington, District of Columbia)
INVENTOR(S)	Thomas Podlesak (Elkton, Maryland); Michael Gonzalez (Bel Air, Maryland)
ABSTRACT	Various embodiments are described that relate an electrical current connector. The electrical current connector can be configured to provide electrical current when pressure is applied to a prong set. This pressure can cause a contact to engage with a connector. This can complete a circuit that allows the electrical current to flow. The connector can be coupled to a cable that can be configured to transfer data along with the electrical current. The cable can have an inner portion that transfers the data while an outer portion that surrounds the inner portion transfers the current.
FILED	Thursday, May 21, 2020
APPL NO	16/879809
ART UNIT	2896 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 31/50 (20200101) Original (OR) Class Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors H01R 13/193 (20130101) H01R 13/641 (20130101) H01R 13/6683 (20130101) H01R 13/7038 (20130101)
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11226427 — Lift-based acoustic source

US 11226427	Ruffa
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Secretary of the Navy (SECNAV)
APPLICANT(S)	The United States of America as represented by the Secretary of the Navy (Newport, Rhode Island)
ASSIGNEE(S)	The United States of America, as represented by the Secretary of the Navy (, None)
INVENTOR(S)	Anthony A Ruffa (Hope Valley, Rhode Island)
ABSTRACT	A lift based acoustic source is towable in an undersea environment by a towing vessel. A controller provides a combined lift control signal and an acoustic source signal. A control cable is joined between the towing vessel and a towed depressor having an active lift control system. The combined signal is used to control the towed depressor active lift control system. The towed depressor lift fluctuates in response to the source signal to generate the undersea acoustic signal. A hydrophone or hydrophone array can be provided for measuring the generated acoustic signal for feedback and monitoring.
FILED	Wednesday, March 11, 2020
APPL NO	16/815055
ART UNIT	3617 — Printing/Measuring and Testing
CURRENT CPC	Ships or Other Waterborne Vessels; Equipment for Shipping B63B 21/66 (20130101) B63B 2211/02 (20130101) Offensive or Defensive Arrangements on Vessels; Mine-laying; Mine-sweeping; Submarines; Aircraft Carriers B63G 8/39 (20130101) Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags G01V 1/133 (20130101) G01V 1/159 (20130101) G01V 1/186 (20130101) G01V 1/3843 (20130101) Original (OR) Class G01V 2210/121 (20130101) G01V 2210/1293 (20130101)
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11226479 — Electrowetting prism for scanning in high resolution fluorescence microscopy

US 11226479	Gopinath et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR) National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Biological Infrastructure (DBI) Directorate for Engineering (ENG) Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF COLORADO (Denver, Colorado)
ASSIGNEE(S)	The Regents of the University of Colorado (Denver, Colorado)
INVENTOR(S)	Juliet T. Gopinath (Boulder, Colorado); Victor M. Bright (Boulder, Colorado); Omkar D. Supekar (Boulder, Colorado); Wei Yang Lim (Boulder, Colorado); Mo Zohrabi (Boulder, Colorado)
ABSTRACT	A system for high resolution multiphoton excitation microscopy is described herein. In one embodiment, the system may include an electrowetting on dielectric (EWOD) prism optically coupled to an excitation source, the EWOD prism adapted or configured to: receive a light beam from the excitation source, and project the received light beam onto a sample plane based on a tunable transmission angle of the EWOD prism, and a fluorescence imaging microscope adapted or configured to: receive a fluorescence signal from the sample plane based on the projected light beam, and relay the fluorescence signal from the sample plane to a set of detectors.
FILED	Wednesday, May 15, 2019
APPL NO	16/413395
ART UNIT	2884 — Optics
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6458 (20130101) Optical Elements, Systems, or Apparatus G02B 3/12 (20130101) G02B 21/0076 (20130101) G02B 26/02 (20130101) G02B 26/005 (20130101) Original (OR) Class
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11226503 — Tunable spectral filters

US 11226503	Currie et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Naval Research Laboratory (NRL) Secretary of the Navy (SECNAV)
APPLICANT(S)	The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
ASSIGNEE(S)	The Government of the United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Marc Currie (Washington, District of Columbia); Virginia D. Wheeler (Alexandria, Virginia); Guy Beadie (Falls Church, Virginia)
ABSTRACT	A tunable spectral filter comprising a phase change material is incorporated into a multilayered dielectric structure. The dielectric permittivity, and thus the filter properties, of the structure can be modified by producing a change in the phase change material, e.g., causing a metal-insulator transition. By controllably causing such a change in the dielectric permittivity of the phase change material, the spectral transmittance and reflectance of the structure, and thus its filter properties, can be modified to provide a predetermined transmittance or reflectance of electromagnetic radiation incident on the structure. In preferred embodiments, the phase change material layer is a vanadium dioxide (VO₂) film formed by atomic layer deposition (ALD).
FILED	Friday, December 13, 2019
APPL NO	16/713032
ART UNIT	2872 — Optics
CURRENT CPC	Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/0102 (20130101) G02F 1/0147 (20130101) Original (OR) Class G02F 2203/055 (20130101)
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11226534 — Methods and apparatus for generating mid-infrared frequency combs

US 11226534	Diddams et al.
FUNDED BY	Department of Commerce (DOC) National Institute of Standards and Technology (NIST) Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	The Regents of the University of Colorado (Denver, Colorado)
ASSIGNEE(S)	Fathom Radiant, PBC (Boulder, Colorado)
INVENTOR(S)	Scott Diddams (Louisville, Colorado); Henry Timmers (Golden, Colorado); Abijith J. Kowligy (Boulder, Colorado); Alexander Jacob Lind (Boulder, Colorado); Scott Papp (Boulder, Colorado)
ABSTRACT	Apparatus and methods for generating mid-IR frequency combs using intra-pulse DFG. A mode-locked pulse generation laser generates near-IR pulses which are amplified. The amplified pulses are spectrally broadened by a nonlinear element, for example a normal dispersion highly nonlinear fiber (ND-HNLF) to generate broadened pulses. The nonlinear spectral broadening element is a transparent dielectric material having a cubic nonlinear response. Broadened pulses are temporally compressed to generate short, high-power pulses which few-cycle conditioned pulses which are ready for the intrapulse DFG process. The DFG block generates a mid-IR comb by difference frequency generation. It might comprise an orientation patterned GaP (OP-GaP) crystal or a poled lithium niobate (PPLN) crystal.
FILED	Wednesday, August 21, 2019
APPL NO	16/546890
ART UNIT	2874 — Optics
CURRENT CPC	Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/365 (20130101) G02F 1/3501 (20130101) Original (OR) Class G02F 1/3503 (20210101) G02F 1/3551 (20130101) G02F 2203/56 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/1671 (20130101)
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11226621 — Method for optimization of robotic transportation systems

US 11226621	Penning et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	Teradyne, Inc. (North Reading, Massachusetts)
ASSIGNEE(S)	TERADYNE, INC. (North Reading, Massachusetts)
INVENTOR(S)	Ryan S. Penning (Madison, Wisconsin); James D. English (Alva, Florida); Douglas E. Barker (Somerville, Massachusetts); Brett L. Limone (Danvers, Massachusetts); Paul Muench (Livonia, Michigan)
ABSTRACT	Embodiments included herein are directed towards a robotic system and method. Embodiments may include a transportation mechanism having at least three legs and a computing device configured to receive a plurality of optimization components. Each optimization component may include a plurality of variables and the computing device may be further configured to perform a randomized simulation based upon, at least in part, each of the plurality of optimization components. The computing device may be further configured to provide one or more results of the randomized simulation to the transportation mechanism to enable locomotion via the at least three legs.
FILED	Thursday, February 14, 2019
APPL NO	16/275431
ART UNIT	3663 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems
CURRENT CPC	Manipulators; Chambers Provided With Manipulation Devices B25J 11/00 (20130101) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 17/02 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/0088 (20130101) Original (OR) Class G05D 2201/0217 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101)
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11226951 — Storage-optimized data-atomic systems and techniques for handling erasures and errors in distributed storage systems

US 11226951	Medard et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts); Northeastern University (Boston, Massachusetts); University of Connecticut (Farmington, Connecticut)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts); Northeastern University (Boston, Massachusetts); University of Connecticut (Farmington, Connecticut)
INVENTOR(S)	Muriel Medard (Belmont, Massachusetts); Kishori Mohan Konwar (Revere, Massachusetts); Prakash Narayana Moorthy (Hillsboro, Oregon); Nancy Ann Lynch (Brookline, Massachusetts); Erez Kantor (Brookline, Massachusetts); Alexander Allister Schwarzmann (Storrs, Connecticut)
ABSTRACT	Described are devices, systems and techniques for implementing atomic memory objects in a multi-writer, multi-reader setting. In an embodiment, the devices, systems and techniques use maximum distance separable (MDS) codes, and may be specifically designed to optimize a total storage cost for a given fault-tolerance requirement. Also described is an embodiment to handle the case where some of the servers can return erroneous coded elements during a read operation.
FILED	Monday, November 23, 2020
APPL NO	17/101400
ART UNIT	2114 — Computer Error Control, Reliability, & Control Systems
CURRENT CPC	Electric Digital Data Processing G06F 3/067 (20130101) G06F 16/00 (20190101) G06F 16/27 (20190101) G06F 16/2329 (20190101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 67/1097 (20130101) H04L 69/26 (20130101)
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11226972 — Ranking collections of document passages associated with an entity name by relevance to a query

US 11226972	Summers et al.
FUNDED BY	Department of Defense (DOD)
APPLICANT(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
ASSIGNEE(S)	International Business Machines Corporation (Armonk, New York)
INVENTOR(S)	Kristen M. Summers (Takoma Park, Maryland); Christopher F. Ackermann (Fairfax, Virginia); Andrew Doyle (Mount Rainer, Maryland); Michael Drzewucki (Woodbridge, Virginia); Charles E. Beller (Baltimore, Maryland)
ABSTRACT	Query service receives a query comprising at least a name component. The query service searches a document corpus to identify multiple passages, each comprising a mention of the name component within a selection of one or more documents of the document corpus. The query service collects bins, each bin comprising a distinct selection of the passages from the one or more documents, each of the bins identifying a separate relationship the name component participates in within the distinct selection of passages. The query service assesses a separate score of each respective bin reflecting the relevance of each respective bin to the query. The query service returns a response to the query with the bins each ranked according to each separate score.
FILED	Tuesday, February 19, 2019
APPL NO	16/278856
ART UNIT	2154 — Data Bases & File Management
CURRENT CPC	Electric Digital Data Processing G06F 16/93 (20190101) G06F 16/285 (20190101) G06F 16/2468 (20190101) G06F 16/24578 (20190101) Original (OR) Class
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11227056 — Inhibiting memory disclosure attacks using destructive code reads

US 11227056	Tang et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computing and Communication Foundations (CCF)
APPLICANT(S)	Adrian Tang (New York, New York); Salvatore Stolfo (New York, New York); Lakshminarasimhan Sethumadhavan (New York, New York)
ASSIGNEE(S)	The Trustees of Columbia University in the City of New York (New York, New York)
INVENTOR(S)	Adrian Tang (New York, New York); Salvatore Stolfo (New York, New York); Lakshminarasimhan Sethumadhavan (New York, New York)
ABSTRACT	Disclosed are devices, systems, apparatus, methods, products, and other implementations, including a method that includes determining whether an operation to access a memory location containing executable code comprises a general-purpose memory access operation, and changing content of the memory location in response to a determination that the operation to access the memory location containing the executable code comprises the general-purpose memory access operation to the memory location.
FILED	Thursday, August 04, 2016
APPL NO	15/753270
ART UNIT	2433 — Cryptography and Security
CURRENT CPC	Electric Digital Data Processing G06F 9/45558 (20130101) G06F 12/1009 (20130101) G06F 12/1475 (20130101) G06F 21/52 (20130101) G06F 21/604 (20130101) G06F 21/6218 (20130101) Original (OR) Class G06F 2009/45583 (20130101) G06F 2009/45595 (20130101)
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11227087 — System, method, and computer program product for distributed learning in an electronic design

US 11227087	White
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	Cadence Design Systems, Inc. (San Jose, California)
ASSIGNEE(S)	Cadence Design Systems, Inc. (San Jose, California)
INVENTOR(S)	David Allan White (San Jose, California)
ABSTRACT	The present disclosure relates to embodiments for collaborative electronic design. Embodiments may include receiving a baseline model at a computing device associated with each of a plurality of geographically dispersed electronic design teams. Embodiments may further include applying environmental data from each of the plurality of geographically dispersed electronic design teams to the baseline model. Embodiments may also include generating a plurality of training changes, based upon, at least in part, the applied environmental data from each of the plurality of geographically dispersed electronic design teams. Embodiments may also include encrypting the plurality of training changes to create a plurality of encrypted training changes. Embodiments may further include providing the plurality of encrypted training changes to a centralized host configured to aggregate the plurality of encrypted training changes.
FILED	Friday, January 04, 2019
APPL NO	16/240377
ART UNIT	2457 — Computer Networks
CURRENT CPC	Electric Digital Data Processing G06F 30/33 (20200101) Original (OR) Class G06F 30/392 (20200101) G06F 30/394 (20200101) G06F 30/398 (20200101) G06F 2111/02 (20200101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6257 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/103 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/0428 (20130101) H04L 67/34 (20130101)
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11227113 — Precision batch interaction with a question answering system

US 11227113	Beller et al.
FUNDED BY	Department of Defense (DOD)
APPLICANT(S)	International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)	International Business Machines Corporation (Armonk, New York)
INVENTOR(S)	Charles Evan Beller (Baltimore, Maryland); William G Dubyak (Severna Park, Maryland); Palani Sakthi (Palatine, Illinois); Kristen Maria Summers (Takoma Park, Maryland)
ABSTRACT	Batch interaction with a computerized question answering system can produce an answer that more closely relates to a user's information need. A batch of questions can be generated interactively, and provides a context for a first question received from a user. The batch of questions includes or more additional questions which have terms with a nonsynonymous semantic relation to a first term in the first question. A question answering system can process the batch of questions to determine candidate answers. An answer to the first question can be determined based, at least in part, on a combined ranking of the candidate answers.
FILED	Wednesday, January 20, 2016
APPL NO	15/001848
ART UNIT	2159 — Data Bases & File Management
CURRENT CPC	Electric Digital Data Processing G06F 3/0482 (20130101) G06F 16/243 (20190101) G06F 16/3329 (20190101) G06F 16/3344 (20190101) G06F 16/90332 (20190101) G06F 40/205 (20200101) G06F 40/284 (20200101) Original (OR) Class
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11227180 — Extracting motion saliency features from video using a neurosynaptic system

US 11227180	Andreopoulos et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)	International Business Machines Corporation (Armonk, New York)
INVENTOR(S)	Alexander Andreopoulos (San Jose, California); Steven K. Esser (San Jose, California); Dharmendra S. Modha (San Jose, California)
ABSTRACT	Embodiments of the invention provide a computer-readable medium of visual saliency estimation comprising receiving an input video of image frames. Each image frame has one or more channels, and each channel has one or more pixels. The computer-readable medium further comprises, for each channel of each image frame, generating corresponding neural spiking data based on a pixel intensity of each pixel of the channel, generating a corresponding multi-scale data structure based on the corresponding neural spiking data, and extracting a corresponding map of features from the corresponding multi-scale data structure. The multi-scale data structure comprises one or more data layers, wherein each data layer represents a spike representation of pixel intensities of a channel at a corresponding scale. The computer-readable medium further comprises encoding each map of features extracted as neural spikes.
FILED	Tuesday, October 15, 2019
APPL NO	16/653712
ART UNIT	2665 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/66 (20130101) G06K 9/00744 (20130101) G06K 9/4604 (20130101) G06K 9/4652 (20130101) G06K 9/4671 (20130101) Original (OR) Class G06K 9/4676 (20130101) Computer Systems Based on Specific Computational Models G06N 3/049 (20130101) G06N 3/063 (20130101)
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11227403 — Anisotropic twicing for single particle reconstruction using autocorrelation analysis

US 11227403	Zhang et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	The Trustees of Princeton University (Princeton, New Jersey)
ASSIGNEE(S)	The Trustees of Princeton University (Princeton, New Jersey)
INVENTOR(S)	Teng Zhang (Oviedo, Florida); Amit Singer (New York, New York); Tejal Bhamre (Mountain View, California)
ABSTRACT	Methods and systems are described for digitally reconstructing an unknown 3D structure of a target molecule using orthogonal extension. A plurality of 2D images of the target molecule are captured by an imaging system. An estimated low-order moment of the unknown 3D structure (e.g., a covariance matrix) is calculated based on the 2D images. A homologous molecule having a known 3D structure is identified and at least one expansion coefficient of the known structure of the homologous molecule is determined. At least one estimated expansion coefficient for the unknown structure is calculated based at least in part on the estimated low order moment of the unknown structure and the at least one expansion coefficient of the known structure. An estimated 3D reconstruction of the target molecule is then generated based on the at least one estimated expansion coefficient for the unknown structure of the target molecule.
FILED	Tuesday, April 24, 2018
APPL NO	16/605987
ART UNIT	2645 — Telecommunications: Analog Radio Telephone; Satellite and Power Control; Transceivers, Measuring and Testing; Bluetooth; Receivers and Transmitters; Equipment Details
CURRENT CPC	Image Data Processing or Generation, in General G06T 7/55 (20170101) Original (OR) Class G06T 17/00 (20130101) G06T 2207/10061 (20130101) G06T 2207/20056 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/00 (20190201) Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 20/20 (20190201)
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11227477 — Systems and methods for determining maximum alert geography for a hazard

US 11227477	Shirkhodai et al.
FUNDED BY	Department of Defense (DOD)
APPLICANT(S)	UNIVERSITY OF HAWAII (Honolulu, Hawaii)
ASSIGNEE(S)	University of Hawaii (Honolulu, Hawaii)
INVENTOR(S)	Ray Shirkhodai (Kihei, Hawaii); David Askov (Seattle, Washington); Douglas B. Bausch (Makawao, Hawaii)
ABSTRACT	Systems and methods are described for performing logical filtering of hazard alerts by an area of geography the hazard is expected to impact and issuing alerts based on that area. Based on a geographical location, a hazard type, and a hazard severity, one or more geographic areas the hazard is expected to impact may be determined. One or more automated alerts may be issued to alert users in those areas that could be affected by the hazard.
FILED	Tuesday, May 14, 2019
APPL NO	16/979217
ART UNIT	2684 — Telemetry and Code Generation Vehicles and System Alarms
CURRENT CPC	Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 21/10 (20130101) Original (OR) Class Wireless Communication Networks H04W 4/022 (20130101) H04W 4/90 (20180201) H04W 76/50 (20180201)
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11227754 — Low-power mass interrogation system and assay for determining vitamin D levels

US 11227754	Christian
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL)
APPLICANT(S)	Leidos, Inc. (Reston, Virginia)
ASSIGNEE(S)	Leidos, Inc. (Reston, Virginia)
INVENTOR(S)	Noah Peter Christian (San Diego, California)
ABSTRACT	A low power mass spectrometer assembly includes at least an ionization component, an electrostatic analyzer, a lens assembly, a magnet assembly and at least one detector located in a same plane as the entrance to the magnet assembly for detecting the deflected sample ions and/or fragments of sample ions, including ions or ion fragments indicative of the Vitamin D metabolite within the sample.
FILED	Tuesday, April 30, 2019
APPL NO	16/399441
ART UNIT	2881 — Optics
CURRENT CPC	Electric Discharge Tubes or Discharge Lamps H01J 49/004 (20130101) Original (OR) Class H01J 49/0013 (20130101) H01J 49/16 (20130101) H01J 49/20 (20130101) H01J 49/24 (20130101) H01J 49/025 (20130101) H01J 49/30 (20130101) H01J 49/067 (20130101)
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11227943 — High electron mobility transistors and methods for fabricating the same

US 11227943	Anderson et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Secretary of the Navy (SECNAV)
APPLICANT(S)	GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (Arlington, Virginia)
ASSIGNEE(S)	The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
INVENTOR(S)	Travis J. Anderson (Alexandria, Virginia); Virginia D. Wheeler (Alexandria, Virginia); Karl D. Hobart (Alexandria, Virginia); Francis J. Kub (Arnold, Maryland)
ABSTRACT	A high electron mobility transistor (HEMT) and method of producing the same are provided. The HEMT includes a barrier layer formed on a GaN layer. The HEMT also includes a ZrO₂gate dielectric layer formed by either a ZTB precursor, a TDMA-Zr precursor, or both. The HEMT may also include a recess in the barrier layer in the gate region of the HEMT. The HEMTs may operate in an enhancement mode.
FILED	Monday, June 25, 2018
APPL NO	16/017833
ART UNIT	2817 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/022 (20130101) H01L 21/0228 (20130101) H01L 21/0254 (20130101) H01L 21/0262 (20130101) H01L 21/02189 (20130101) H01L 21/02205 (20130101) H01L 21/02274 (20130101) H01L 21/28264 (20130101) H01L 23/3171 (20130101) H01L 29/205 (20130101) H01L 29/408 (20130101) H01L 29/452 (20130101) H01L 29/513 (20130101) H01L 29/517 (20130101) H01L 29/2003 (20130101) H01L 29/4236 (20130101) H01L 29/7786 (20130101) H01L 29/7787 (20130101) Original (OR) Class H01L 29/66462 (20130101)
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11227988 — Fast-rate thermoelectric device

US 11227988	Venkatasubramanian et al.
FUNDED BY	Department of Defense (DOD) Uniformed Services University of the Health Sciences (USUHS)
APPLICANT(S)	The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S)	The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S)	Rama Venkatasubramanian (Cary, North Carolina); Luke E. Osborn (Baltimore, Maryland); Robert S. Armiger (Catonsville, Maryland); Meiyong Himmtann (Laurel, Maryland); Jonathan M. Pierce (North Eldersburg, Maryland)
ABSTRACT	A fast-rate thermoelectric device control system includes a fast-rate thermoelectric device, a sensor, and a controller. The fast-rate thermoelectric device includes a thermoelectric actuator array disposed on a wafer, and the thermoelectric actuator array includes a thin-film thermoelectric (TFTE) actuator that generates a heating and/or a cooling effect in response to an electrical current. The sensor is configured to measure a temperature associated with the heating or cooling effect and output a feedback signal indicative of the measured temperature. The controller is in communication with the fast-rate thermoelectric device and the sensor, and is configured to control the electrical current based on the feedback signal.
FILED	Wednesday, September 30, 2020
APPL NO	17/038614
ART UNIT	1721 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Refrigeration Machines, Plants or Systems; Combined Heating and Refrigeration Systems; Heat-pump Systems F25B 21/02 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/16 (20130101) H01L 35/16 (20130101) H01L 35/30 (20130101) Original (OR) Class H01L 35/325 (20130101)
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11229125 — Motion-based reconfigurable microelectronics system

US 11229125	Pulskamp
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Secretary of the Army (SECARMY)
APPLICANT(S)	U.S. Army Research Laboratory ATTN: CCRL-LOC-I (Adelphi, Maryland)
ASSIGNEE(S)	The United States of America as represented by the Secretary of the Army (Washington, District of Columbia)
INVENTOR(S)	Jeffrey Spencer Pulskamp (Fulton, Maryland)
ABSTRACT	A system for controlled motion of circuit components to create reconfigurable circuits comprising: a support; a substrate operatively associated with the support; actuators operatively associated with the support configured to physically move circuit components and to move the circuit components into physical and electrical contact with the substrate; the substrate comprising at least one conductive segment arranged to electrically connect circuit components when electrical contacts of circuit components are placed in contact with at least one conductive segment; and control circuitry configured to control the first and second actuators to thereby position the circuit components relative to the substrate; whereby circuit function is determined by the selection of circuit components and the location and orientation of circuit components relative to the substrate and conductive segments to create a reconfigurable circuit.
FILED	Thursday, March 07, 2019
APPL NO	16/295177
ART UNIT	3729 — Manufacturing Devices & Processes, Machine Tools & Hand Tools Group Art Units
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/20 (20130101) H01L 41/094 (20130101) Electric Machines Not Otherwise Provided for H02N 2/0095 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/029 (20130101) H05K 3/0008 (20130101) H05K 3/303 (20130101) Original (OR) Class H05K 2201/1009 (20130101) H05K 2203/173 (20130101) H05K 2203/1509 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 70/50 (20151101) Technical Subjects Covered by Former US Classification Y10T 29/53174 (20150115)
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Department of Energy (DOE)

11224918 — SRF e-beam accelerator for metal additive manufacturing

US 11224918	Thangaraj et al.
FUNDED BY	Department of Energy (DOE) Fermi National Accelerator Laboratory (FNAL) Fermi Research Alliance, LLC (FRA)
APPLICANT(S)	Fermi Research Alliance, LLC (Batavia, Illinois)
ASSIGNEE(S)	FERMI RESEARCH ALLIANCE, LLC (Batavia, Illinois)
INVENTOR(S)	Jayakar C Thangaraj (Aurora, Illinois); Robert Kephart (Pioneer, California); Thomas K Kroc (Batavia, Illinois)
ABSTRACT	A system and apparatus for electron beam melting comprises a superconducting radio frequency accelerator configured to produce an electron beam, a conduction cooling system configured to cool the superconducting radio frequency accelerator, and an electron beam melting system wherein the electron beam melts power in a build chamber of the electron beam melting apparatus.
FILED	Thursday, January 17, 2019
APPL NO	16/250899
ART UNIT	2879 — Optics
CURRENT CPC	Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/10 (20210101) B22F 10/28 (20210101) B22F 10/36 (20210101) B22F 10/64 (20210101) B22F 12/00 (20210101) Original (OR) Class B22F 12/41 (20210101) Electric Discharge Tubes or Discharge Lamps H01J 37/073 (20130101) Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 7/20 (20130101) H05H 7/22 (20130101) H05H 2007/227 (20130101)
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11225415 — Advanced oxidation process for the exfoliation of two dimensional matertals

US 11225415	Markou et al.
FUNDED BY	Department of Energy (DOE) Argonne National Laboratory (ANL) UChicago Argonne, LLC (UCHICAGO) National Science Foundation (NSF) Directorate for Engineering (ENG)
APPLICANT(S)	UCHICAGO ARGONNE, LLC (Chicago, Illinois)
ASSIGNEE(S)	UChicago Argonne, LLC (Chicago, Illinois)
INVENTOR(S)	Demetrios Markou (Lemont, Illinois); Anirudha V. Sumant (Plainfield, Illinois)
ABSTRACT	A system for extracting two dimensional materials from a bulk material by functionalization of the bulk material in a reactor.
FILED	Friday, August 03, 2018
APPL NO	16/054868
ART UNIT	1736 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 8/10 (20130101) B01J 8/16 (20130101) B01J 8/085 (20130101) B01J 8/087 (20130101) B01J 19/02 (20130101) B01J 19/008 (20130101) B01J 19/10 (20130101) B01J 19/18 (20130101) B01J 19/123 (20130101) B01J 2208/00176 (20130101) B01J 2208/00212 (20130101) B01J 2208/00867 (20130101) B01J 2219/089 (20130101) B01J 2219/00094 (20130101) B01J 2219/00189 (20130101) B01J 2219/0209 (20130101) B01J 2219/0254 (20130101) B01J 2219/0286 (20130101) B01J 2219/0871 (20130101) B01J 2219/1203 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) B82Y 40/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/19 (20170801) C01B 32/192 (20170801) Original (OR) Class C01B 2204/02 (20130101) C01B 2204/04 (20130101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 39/06 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/82 (20130101) C01P 2002/84 (20130101) C01P 2004/20 (20130101)
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11225502 — Controlled synthesis of hierarchically-structured hybrid materials through peptoid engineering

US 11225502	Chen
FUNDED BY	Department of Energy (DOE) Battelle Memorial Institute (BATTELLE) Pacific Northwest National Laboratory (PNNL)
APPLICANT(S)	Battelle Memorial Institute (Richland, Washington)
ASSIGNEE(S)	Battelle Memorial Institute (Richland, Washington)
INVENTOR(S)	Chun-Long Chen (Richland, Washington)
ABSTRACT	This disclosure concerns a method for making a hybrid organic/inorganic material having an architecture. The method includes combining a peptoid comprising a sequence of N-substituted glycine residues and an inorganic material or inorganic material precursor to form a hybrid organic/inorganic material comprising the peptoid and the inorganic material, the hybrid organic/inorganic material having an architecture based at least in part on the peptoid sequence. The hybrid organic/inorganic materials include a cluster of nanoparticles of an inorganic material and peptoids, the cluster formed by random attachment of nanoparticles to one another by peptoid-peptoid and peptoid-nanoparticle surface interactions, wherein the hybrid material has an architecture based at least in part on the peptoid sequence.
FILED	Wednesday, June 05, 2019
APPL NO	16/432710
ART UNIT	1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) B82Y 40/00 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/087 (20130101) Peptides C07K 1/1077 (20130101) C07K 7/02 (20130101) Original (OR) Class C07K 14/001 (20130101)
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11225622 — Compounds that induce octane overboosting

US 11225622	Monroe et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) National Technology and Engineering Solutions of Sandia, LLC (NTESS) Sandia National Laboratories (SNL)
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	Eric Monroe (Waltham, Massachusetts); Ryan Wesley Davis (San Jose, California); Anthe George (San Francisco, California); Joseph Carlson (Castro Valley, California); Nicholas Myllenbeck (Livermore, California)
ABSTRACT	A fuel mixture includes a fuel and an octane overboosting additive. Methods of preparing and using such mixtures are disclosed. In particular, the mixture includes an additive that provides octane boosting that produces peak octane at or before a 40% blend and produces at least a 1 octane boost at 10% volume of additive to fuel mixture.
FILED	Tuesday, January 19, 2021
APPL NO	17/151808
ART UNIT	1771 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC	Fuels Not Otherwise Provided for; Natural Gas; Synthetic Natural Gas Obtained by Processes Not Covered by Subclasses C10G, C10K; Liquefied Petroleum Gas; Adding Materials to Fuels or Fires to Reduce Smoke or Undesirable Deposits or to Facilitate Soot Removal; Firelighters C10L 1/06 (20130101) C10L 1/1608 (20130101) C10L 1/1824 (20130101) C10L 10/10 (20130101) Original (OR) Class C10L 2200/0423 (20130101) C10L 2200/0469 (20130101) C10L 2270/023 (20130101) C10L 2290/24 (20130101)
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11226281 — Non-invasive, in situ diagnosis and monitoring of corrosion in high temperature systems

US 11226281	Findikoglu et al.
FUNDED BY	Department of Energy (DOE) Los Alamos National Laboratory (LANL) National Nuclear Security Administration (NNSA) Triad National Security, LLC (Triad)
APPLICANT(S)	Triad National Security, LLC (Los Alamos, New Mexico)
ASSIGNEE(S)	Triad National Security, LLC (Los Alamos, New Mexico)
INVENTOR(S)	Alp Tugrul Findikoglu (Los Alamos, New Mexico); George Scott Goff (Los Alamos, New Mexico)
ABSTRACT	Techniques for non-invasive diagnosis and/or monitoring of corrosion in high temperature systems using specialized sensors that produce multi-mode acoustic signals in situ for accurate determination of wall loss and/or physical property changes for a vessel in contact with a high temperature, highly corrosive substance are disclosed. Sensitivity of a few microns (or about 0.1%) of wall loss, detection of changes in physical properties of vessel contents (e.g., approximately 1%), or both, at temperatures of 500° C., 600° C., or higher may be realized. Corrosion may be identified and/or monitored using time domain, frequency domain, or mixed time domain and frequency domain analysis of signal characteristics, signal delay, or both, for relatively short circumferential acoustic wave propagation (e.g., a few inches), as well as relatively long axial acoustic wave propagation (e.g., tens of feet).
FILED	Wednesday, March 18, 2020
APPL NO	16/822694
ART UNIT	2861 — Printing/Measuring and Testing
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 17/043 (20130101) Original (OR) Class G01N 29/07 (20130101) G01N 29/46 (20130101) G01N 29/2437 (20130101) G01N 2291/011 (20130101) G01N 2291/023 (20130101) G01N 2291/028 (20130101) G01N 2291/048 (20130101) G01N 2291/102 (20130101)
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11226306 — Microbial sensor system for monitoring and imaging of an environment

US 11226306	Burge et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC)
APPLICANT(S)	Scott R. Burge (Tempe, Arizona); David A. Hoffman (Tempe, Arizona)
ASSIGNEE(S)	Burge Environmental. Inc. (Tempe, Arizona)
INVENTOR(S)	Scott R. Burge (Tempe, Arizona); David A. Hoffman (Tempe, Arizona)
ABSTRACT	A microbial sensor, microbial sensing system, and method that can be used to determine the chemical environment of unsaturated soils, rhizosphere, and/or plants are disclosed. The microbial sensing system can be used for monitoring the health of plants including nutrients, salinity, contaminants, chemicals (pesticides, herbicides) and diseases. A microbial sensing system can include one or more indicator electrodes and a reference electrode. The microbial sensing system can include a signal acquisition and/or communication module to allow the real-time collection of data from field deployments and laboratory investigations.
FILED	Wednesday, October 10, 2018
APPL NO	16/156927
ART UNIT	1795 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Horticulture; Cultivation of Vegetables, Flowers, Rice, Fruit, Vines, Hops or Seaweed; Forestry; Watering A01G 7/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/301 (20130101) G01N 27/3273 (20130101) G01N 27/4161 (20130101) Original (OR) Class G01N 33/24 (20130101) G01N 33/48707 (20130101) G01N 2033/245 (20130101)
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11226312 — In-process, layer-by-layer non-destructive testing of additive manufactured components using linear and nonlinear vibrational resonance

US 11226312	Remillieux et al.
FUNDED BY	Department of Energy (DOE) Los Alamos National Laboratory (LANL) Los Alamos National Security, LLC (LANS) National Nuclear Security Administration (NNSA) Triad National Security, LLC (Triad)
APPLICANT(S)	LOS ALAMOS NATIONAL SECURITY, LLC (Los Alamos, New Mexico)
ASSIGNEE(S)	TRIAD NATIONAL SECURITY, LLC (Los Alamos, New Mexico)
INVENTOR(S)	Marcel Remillieux (Los Alamos, New Mexico); Carly M. Donahue (Los Alamos, New Mexico); Marcie A. Stuber Geesey (Los Alamos, New Mexico)
ABSTRACT	Provided is an additive manufacturing system capable of performing in-process, layer-by-layer non-destructive testing, the additive manufacturing system including: a plate for producing a part thereon; a transducer attached to the plate and configured to induce vibrations in the part; and a laser vibrometer configured to detect a vibrational response of the part to determine whether defect and/or anisotropy exists within the part.
FILED	Friday, August 03, 2018
APPL NO	16/054932
ART UNIT	2856 — Printing/Measuring and Testing
CURRENT CPC	Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/153 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 30/00 (20141201) B33Y 40/00 (20141201) Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 5/0066 (20130101) G01M 7/025 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/045 (20130101) Original (OR) Class
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11226502 — Photonic integrated circuits for generating high-brightness squeezed light

US 11226502	Soh et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) National Technology and Engineering Solutions of Sandia, LLC (NTESS) Sandia National Laboratories (SNL)
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	Daniel Beom Soo Soh (Pleasanton, California); Matt Eichenfield (Albuquerque, New Mexico); Christopher Michael Long (Albuquerque, New Mexico)
ABSTRACT	A high-brightness squeezed light source includes a plurality of light squeezing elements and a photonic summing device. The light squeezing elements each output respective squeezed light responsive to receipt of unsqueezed light. The photonic summing device receives the squeezed light output by each of the light squeezing elements and coherently adds the squeezed light to generate a high-brightness squeezed light output. The high-brightness squeezed light output has a greater brightness than the outputs of the light squeezing elements, and a same degree of squeezing as one or more of the outputs of the light squeezing elements.
FILED	Tuesday, October 27, 2020
APPL NO	17/081233
ART UNIT	2874 — Optics
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 6/12 (20130101) G02B 6/305 (20130101) G02B 6/1225 (20130101) G02B 6/12004 (20130101) G02B 26/001 (20130101) G02B 2006/1213 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/0128 (20130101) G02F 1/0131 (20130101) G02F 1/0134 (20130101) Original (OR) Class G02F 1/212 (20210101) G02F 1/225 (20130101) G02F 1/2257 (20130101)
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11227693 — Hohlraum used as a single turn solenoid to generate seed magnetic field for inertial confinement fusion

US 11227693	Perkins et al.
FUNDED BY	Department of Energy (DOE) Lawrence Livermore National Laboratory (LLNL) Lawrence Livermore National Security LLC (LLNS)
APPLICANT(S)	LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California)
ASSIGNEE(S)	Lawrence Livermore National Security, LLC (Livermore, California)
INVENTOR(S)	Lindsay John Perkins (Pleasanton, California); Jim H. Hammer (Livermore, California); John H. Moody (Livermore, California); Max Tabak (Livermore, California); Burl Grant Logan (Danville, California)
ABSTRACT	Application of axial seed magnetic fields in the range 20-100 T that compress to greater than 10,000 T (100 MG) under typical NIF implosion conditions may significantly relax the conditions required for ignition and propagating burn in NIF ignition targets that are degraded by hydrodynamic instabilities. Such magnetic fields can: (a) permit the recovery of ignition, or at least significant alpha particle heating, in submarginal NIF targets that would otherwise fail because of adverse hydrodynamic instability growth, (b) permit the attainment of ignition in conventional cryogenic layered solid-DT targets redesigned to operate under reduced drive conditions, (c) permit the attainment of volumetric ignition in simpler, room-temperature single-shell DT gas capsules, and (d) ameliorate adverse hohlraum plasma conditions during laser drive and capsule compression. In general, an applied magnetic field should always improve the ignition condition for any NIF ignition target design.
FILED	Friday, October 05, 2018
APPL NO	16/152716
ART UNIT	3646 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Fusion Reactors G21B 1/03 (20130101) G21B 1/05 (20130101) Original (OR) Class G21B 1/19 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 30/10 (20130101)
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11227844 — Gallium nitride electromagnetic pulse arrestor

US 11227844	Kaplar et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) National Technology and Engineering Solutions of Sandia, LLC (NTESS) Sandia National Laboratories (SNL)
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	Robert Kaplar (Albuquerque, New Mexico); Jack David Flicker (Albuquerque, New Mexico); Olga Lavrova (Albuquerque, New Mexico)
ABSTRACT	A GaN diode EMP arrestor exhibits breakdown in <10 ns at reverse-bias voltage >20 kV. Additionally, the arrestor exhibits avalanche ruggedness at 1 kA/cm²in a 1 mm²device (i.e. 10 A absolute current) over a period of 500 ns following the onset of breakdown. Finally, the specific on-resistance in the forward direction is <20 mΩ cm².
FILED	Tuesday, October 01, 2019
APPL NO	16/589428
ART UNIT	2897 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/62 (20130101) Original (OR) Class H01L 29/365 (20130101) H01L 29/0623 (20130101) H01L 29/2003 (20130101) H01L 29/8611 (20130101)
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11227962 — Wire-based metallization and stringing for solar cells

US 11227962	Sewell et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S)	SunPower Corporation (San Jose, California)
ASSIGNEE(S)	SunPower Corporation (San Jose, California)
INVENTOR(S)	Richard Hamilton Sewell (Los Altos, California); David Aaron Randolph Barkhouse (Oakland, California); Douglas Rose (Vista, California); Lewis Abra (San Francisco, California)
ABSTRACT	Wire-based metallization and stringing techniques for solar cells, and the resulting solar cells, modules, and equipment, are described. In an example, a substrate has a surface. A plurality of N-type and P-type semiconductor regions is disposed in or above the surface of the substrate. A conductive contact structure is disposed on the plurality of N-type and P-type semiconductor regions. The conductive contact structure includes a plurality of conductive wires, each conductive wire of the plurality of conductive wires essentially continuously bonded directly to a corresponding one of the N-type and P-type semiconductor regions.
FILED	Friday, March 29, 2019
APPL NO	16/370422
ART UNIT	1721 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/188 (20130101) H01L 31/0516 (20130101) Original (OR) Class H01L 31/02013 (20130101)
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11227964 — Luminescent solar concentrators and related methods of manufacturing

US 11227964	Needell et al.
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S)	California Institute of Technology (Pasadena, California); The Regents of the University of California (Oakland, California); The Board of Trustees of the University of Illinois (Urbana, Illinois)
ASSIGNEE(S)	California Institute of Technology (Pasadena, California); The Regents of the University of California (Oakland, California); The Board of Trustees of the University of Illinois (Urbana, Illinois)
INVENTOR(S)	David R. Needell (Pasadena, California); Noah Bronstein (Golden, Colorado); Armand P. Alivisatos (Berkeley, California); Harry A. Atwater (South Pasadena, California); Ralph Nuzzo (Champaign, Illinois); Haley Bauser (Pasadena, California); Ognjen Ilic (Minneapolis, Minnesota); Junwen He (Urbana, Illinois); Lu Xu (Santa Clara, California); Colton Bukowsky (Pasadena, California); Sunita Darbe (Pasadena, California); Zach Nett (San Francisco, California); Brent Koscher (Somerville, Massachusetts)
ABSTRACT	Luminescent solar concentrators in accordance with various embodiments of the invention can be designed to minimize photon thermalization losses and incomplete light trapping using various components and techniques. Cadmium selenide core, cadmium sulfide shell (CdSe/CdS) quantum dot (“QD”) technology can be implemented in such devices to allow for near-unity QDs and sufficiently large Stokes shifts. Many embodiments of the invention include a luminescent solar concentrator that incorporates CdSe/CdS quantum dot luminophores. In further embodiments, anisotropic luminophore emission can be implemented through metasurface/plasmonic antenna coupling. In several embodiments, red-shifted luminophores are implemented. Additionally, top and bottom spectrally-selective filters, such as but not limited to selectively-reflective metasurface mirrors and polymeric stack filters, can be implemented to enhance the photon collection efficiency. In some embodiments, luminescent solar concentrator component is optically connected in tandem with a planar Si subcell, forming a micro-optical tandem luminescent solar concentrator.
FILED	Monday, August 27, 2018
APPL NO	16/113844
ART UNIT	1726 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/048 (20130101) H01L 31/055 (20130101) Original (OR) Class H01L 31/056 (20141201) H01L 31/0547 (20141201) H01L 31/0684 (20130101) H01L 31/0693 (20130101) H01L 31/02165 (20130101) H01L 31/02168 (20130101)
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11228039 — Chromate based ceramic anode materials for solid oxide fuel cells

US 11228039	Abdul Jabbar et al.
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S)	University of Maryland, College Park (College Park, Maryland)
ASSIGNEE(S)	University of Maryland, College Park (College Park, Maryland)
INVENTOR(S)	Mohammed Hussain Abdul Jabbar (College Park, Maryland); Eric D. Wachsman (Fulton, Maryland); Ke-Ji Pan (North Bethesda, Maryland)
ABSTRACT	The disclosure relates to solid oxide fuel cell (SOFC) anode materials that comprise various compositions of chromate based oxide materials. These materials offer high conductivity achievable at intermediate and low temperatures and can be used to prepare the anode layer of a SOFC. A method of making a low- or intermediate-temperature SOFC having an anode layer comprising a chromate based oxide material is also provided.
FILED	Tuesday, September 25, 2018
APPL NO	16/141051
ART UNIT	1725 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 37/14 (20130101) C01G 39/006 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/34 (20130101) C01P 2002/52 (20130101) C01P 2002/54 (20130101) C01P 2002/60 (20130101) C01P 2002/72 (20130101) C01P 2002/77 (20130101) C01P 2004/03 (20130101) C01P 2006/32 (20130101) C01P 2006/40 (20130101) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/12 (20130101) C04B 35/62675 (20130101) C04B 35/62695 (20130101) C04B 2235/442 (20130101) C04B 2235/768 (20130101) C04B 2235/3208 (20130101) C04B 2235/3213 (20130101) C04B 2235/3224 (20130101) C04B 2235/3225 (20130101) C04B 2235/3227 (20130101) C04B 2235/3251 (20130101) C04B 2235/3256 (20130101) C04B 2235/3281 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/9033 (20130101) Original (OR) Class H01M 2004/8684 (20130101) H01M 2008/1293 (20130101)
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11228051 — Electrochemical cell and method of using same

US 11228051	Beachy et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC)
APPLICANT(S)	Power to Hydrogen LLC (Columbus, Ohio)
ASSIGNEE(S)
INVENTOR(S)	Michael G. Beachy (Gahana, Ohio); Christopher T. Holt (Bexley, Ohio); Minette Ocampo (Columbus, Ohio); Paul H. Matter (Columbus, Ohio)
ABSTRACT	A novel electrochemical cell is disclosed in multiple embodiments. The instant invention relates to an electrochemical cell design. In one embodiment, the cell design can electrolyze water into pressurized hydrogen using low-cost materials. In another embodiment, the cell design can convert hydrogen and oxygen into electricity. In another embodiment, the cell design can electrolyze water into hydrogen and oxygen for storage, then later convert the stored hydrogen and oxygen back into electricity and water. In some embodiments, the cell operates with a wide internal pressure differential.
FILED	Monday, October 19, 2020
APPL NO	17/074297
ART UNIT	1725 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/04 (20130101) C25B 9/23 (20210101) C25B 9/73 (20210101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/122 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/18 (20130101) H01M 8/023 (20130101) H01M 8/0271 (20130101) H01M 8/1004 (20130101) Original (OR) Class H01M 8/04432 (20130101)
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11228052 — Integrated hydrogen recycle system using pressurized multichamber tank

US 11228052	Song et al.
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S)	ESS TECH, INC. (Wilsonville, Oregon)
ASSIGNEE(S)	ESS TECH, INC. (Wilsonville, Oregon)
INVENTOR(S)	Yang Song (West Linn, Oregon); Kenneth Kiyoshi Fisher (Portland, Oregon); Timothy McDonald (Portland, Oregon)
ABSTRACT	A multi-chambered electrolyte storage tank for a redox flow battery system, may include first and second electrolyte chambers, and a bulkhead, wherein the first and second electrolyte chambers are fluidly coupled to first and second sides of a redox flow battery cell, respectively, the first and second electrolyte chambers include first and second liquid electrolyte volumes, respectively, and the first and second liquid electrolyte volumes are separated by the bulkhead positioned therebetween. In this way, manufacturing and operational complexity of a redox flow battery system can be reduced.
FILED	Friday, April 27, 2018
APPL NO	15/965627
ART UNIT	1723 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/188 (20130101) Original (OR) Class H01M 8/0202 (20130101) H01M 8/0289 (20130101) H01M 8/2455 (20130101) H01M 8/2484 (20160201) H01M 8/04037 (20130101) H01M 8/04097 (20130101) H01M 8/04201 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/50 (20130101)
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11228180 — Hierarchical distributed voltage regulation

US 11228180	Zhou et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE) Alliance for Sustainable Energy, LLC (ASE) National Renewable Energy Laboratory (NREL)
APPLICANT(S)	Alliance for Sustainable Energy, LLC (Golden, Colorado); The Regents of the University of Colorado, a body corporate (Denver, Colorado)
ASSIGNEE(S)	Alliance for Sustainable Energy, LLC (Golden, Colorado); The Regents of the University of Colorado, a body corporate (Denver, Colorado)
INVENTOR(S)	Xinyang Zhou (Golden, Colorado); Changhong Zhao (Lakewood, Colorado); Zhiyuan Liu (Boulder, Colorado); Lijun Chen (South Pasadena, California)
ABSTRACT	Embodiments of the disclosure provide for hierarchically distributed voltage regulation and power flow optimization in a power distribution network. According to one embodiment, a regional coordinator system may determine power flow for an autonomous grid (AG) representing a portion of the distribution network based on a set of voltage parameters from nodes in the AG. The set of voltage parameters my include a current voltage magnitude. The regional coordinator system may provide, to a central controller system of the distribution network, one or more power flow parameters based on the determined power flow for the AG.
FILED	Thursday, July 09, 2020
APPL NO	16/925225
ART UNIT	2119 — Computer Error Control, Reliability, & Control Systems
CURRENT CPC	Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/042 (20130101) G05B 2219/2639 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/32 (20130101) H02J 3/381 (20130101) Original (OR) Class H02J 13/00002 (20200101) H02J 2300/24 (20200101) H02J 2300/28 (20200101)
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11228430 — Communication systems and methods

US 11228430	Bush
FUNDED BY	Department of Energy (DOE) Office of Fossil Energy and Carbon Management (FE) National Energy Technology Laboratory (NETL)
APPLICANT(S)	General Electric Company (Schenectady, New York)
ASSIGNEE(S)	General Electric Technology Gmbh (baden, Switzerland)
INVENTOR(S)	Stephen Francis Bush (Latham, New York)
ABSTRACT	A communication system is provided that include one or more processors that are configured to instruct computing devices that communicate messages with each other via a time-sensitive network to securely exchange the messages using secret information, ad direct the computing devices to exchange the secret information via a dedicated quantum channel in the time-sensitive network. The one or more processors are also configured to determine a quantum channel synchronization time associated with the secret information exchanged via the dedicated quantum channel, and modify a local classical oscillator based on the quantum channel synchronization time, the local classical oscillator configured to provide a current time.
FILED	Thursday, September 12, 2019
APPL NO	16/569355
ART UNIT	2435 — Cryptography and Security
CURRENT CPC	Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/12 (20130101) H04L 9/0852 (20130101) Original (OR) Class H04L 63/04 (20130101)
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11228431 — Communication systems and methods for authenticating data packets within network flow

US 11228431	Bush
FUNDED BY	Department of Energy (DOE) Office of Fossil Energy and Carbon Management (FE) National Energy Technology Laboratory (NETL)
APPLICANT(S)	General Electric Company (Schenectady, New York)
ASSIGNEE(S)	General Electric Company (Schenectady, New York)
INVENTOR(S)	Stephen Francis Bush (Latham, New York)
ABSTRACT	A communication system includes a first quantum key distribution device and an intermediary device. The first quantum key distribution device is configured to be coupled to a second quantum key distribution device over a quantum channel and to generate a shared key with the second quantum key distribution device based on a quantum state transmitted along the quantum channel. The intermediary device is disposed along a communication pathway within a network between a sender device and a receiver device. The intermediary device is communicatively connected to the first quantum key distribution device and configured to utilize the shared key to authenticate one or more data packets communicated from the sender device along the communication pathway by examining the one or more data packets for a presence of an information pattern that is associated with the shared key.
FILED	Friday, September 20, 2019
APPL NO	16/578057
ART UNIT	2492 — Cryptography and Security
CURRENT CPC	Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0819 (20130101) H04L 9/0852 (20130101) Original (OR) Class H04L 63/08 (20130101) H04L 63/061 (20130101)
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National Science Foundation (NSF)

11225415 — Advanced oxidation process for the exfoliation of two dimensional matertals

US 11225415	Markou et al.
FUNDED BY	Department of Energy (DOE) Argonne National Laboratory (ANL) UChicago Argonne, LLC (UCHICAGO) National Science Foundation (NSF) Directorate for Engineering (ENG)
APPLICANT(S)	UCHICAGO ARGONNE, LLC (Chicago, Illinois)
ASSIGNEE(S)	UChicago Argonne, LLC (Chicago, Illinois)
INVENTOR(S)	Demetrios Markou (Lemont, Illinois); Anirudha V. Sumant (Plainfield, Illinois)
ABSTRACT	A system for extracting two dimensional materials from a bulk material by functionalization of the bulk material in a reactor.
FILED	Friday, August 03, 2018
APPL NO	16/054868
ART UNIT	1736 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 8/10 (20130101) B01J 8/16 (20130101) B01J 8/085 (20130101) B01J 8/087 (20130101) B01J 19/02 (20130101) B01J 19/008 (20130101) B01J 19/10 (20130101) B01J 19/18 (20130101) B01J 19/123 (20130101) B01J 2208/00176 (20130101) B01J 2208/00212 (20130101) B01J 2208/00867 (20130101) B01J 2219/089 (20130101) B01J 2219/00094 (20130101) B01J 2219/00189 (20130101) B01J 2219/0209 (20130101) B01J 2219/0254 (20130101) B01J 2219/0286 (20130101) B01J 2219/0871 (20130101) B01J 2219/1203 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) B82Y 40/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/19 (20170801) C01B 32/192 (20170801) Original (OR) Class C01B 2204/02 (20130101) C01B 2204/04 (20130101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 39/06 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/82 (20130101) C01P 2002/84 (20130101) C01P 2004/20 (20130101)
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11225507 — Conformation switchable antimicrobial peptides and methods of using the same

US 11225507	Cheng et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
ASSIGNEE(S)	The Board of Trustees of the University of Illinois (Urbana, Illinois)
INVENTOR(S)	Jianjun Cheng (Champaign, Illinois); Lin-Feng Chen (Champaign, Illinois); Menghua Xiong (Guangzhou, China PRC); Yan Bao (Guangzhou, China PRC)
ABSTRACT	The disclosure provides a class of pH-sensitive, helix/random conformation switchable antimicrobial polypeptide (HRS-AMP) compositions as a single agent to selectively kill bacteria (e.g., H. pylori) under acidic condition in the stomach with diminished bacterial resistance compared to currently used antibiotics. Methods of treating bacterial infections in the stomach are also provided.
FILED	Thursday, January 25, 2018
APPL NO	16/480914
ART UNIT	1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 1/1072 (20130101) C07K 14/001 (20130101) Original (OR) Class
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11225554 — Synthetically modified thermoplastic polymer composites having cellulose nanomaterials

US 11225554	Teipel et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	Essentium, Inc. (Pflugerville, Texas)
ASSIGNEE(S)	Essentium, Inc. (Pflugerville, Texas)
INVENTOR(S)	Blake Teipel (Pflugerville, Texas); Elisa Teipel (Pflugerville, Texas); Matt Kirby (San Antonio, Texas); Ryan Vano (Pflugerville, Texas); Mustafa Akbulut (College Station, Texas)
ABSTRACT	A method of manufacturing a polymer coated cellulose nanocrystal composite material begins with an aqueous cellulose nanocrystal (CNC) suspension mixture. The aqueous CNC suspension mixture is dried to remove the liquid solvent from the aqueous CNC suspension mixture to form a dry CNC powder. Diethylenetriamine (DETA) is combined with melted Maleated-anhydride Polypropylene (MAPP) to form a DETA-functionalized MAPP (MA) mixture. The MA mixture is cooled and pelletized to form MA pellets. The MA pellets, the dry CNC powder, and a neat polypropylene (PP) are combined to form a CNC-PP mixture. The CNC-PP mixture is compounded by melting, subsequently cooled and pelletized to form CNC-PP pellets.
FILED	Monday, March 16, 2020
APPL NO	16/820026
ART UNIT	1742 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 120/08 (20130101) C08F 2500/24 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/126 (20130101) Original (OR) Class C08J 2300/22 (20130101) Compositions of Macromolecular Compounds C08L 1/02 (20130101) C08L 33/00 (20130101) C08L 2205/16 (20130101) C08L 2205/18 (20130101) C08L 2207/53 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 123/26 (20130101)
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11225657 — Synthetic auxotrophs with ligand dependent essential genes for biosafety

US 11225657	Anderson et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	John C. Anderson (Berkeley, California); Gabriel Lopez (Altadena, California)
ABSTRACT	Synthetic auxotrophs with one or more ligand-dependent essential gene functions and methods of production that can be used for biosafety. The ligand-dependent function of an essential gene product can be produced by a series of mutations in the ORF of an essential gene; N, C, or insertional fusions of ligand-binding domains with essential genes or an engineered ligand-dependent intein splicing to alter essential gene function. A positive and/or negative selection can be used to identify auxotrophs from created mutant libraries. The positive selection is performed by growing a mutant library in conditions where growth or viability depends on the function of mutagenized essential genes. The negative selection eliminates constitutively growing cells that do not require a ligand for growth by growing the library in the absence of complementing ligand and in conditions where growing cells are eliminated. Desirable phenotypes are collected after the selections.
FILED	Monday, November 27, 2017
APPL NO	15/823238
ART UNIT	1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 1/36 (20130101) C12N 15/52 (20130101) C12N 15/1027 (20130101) C12N 15/1031 (20130101) C12N 15/1058 (20130101) C12N 15/1079 (20130101) Original (OR) Class C12N 15/1093 (20130101)
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11226336 — Compact and homogeneous quantum dots and methods of making the same

US 11226336	Smith et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Environmental Health Sciences (NIEHS) National Institute of Neurological Disorders and Stroke (NINDS) National Science Foundation (NSF)
APPLICANT(S)	The Board of Trustees of the University of Illinois (Urbana, Illinois)
ASSIGNEE(S)	THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
INVENTOR(S)	Andrew M. Smith (Savoy, Illinois); Chunlai Tu (Urbana, Illinois); Liang Ma (Urbana, Illinois)
ABSTRACT	The present disclosure provides quantum dots and methods of making the quantum dots comprising a substantially homogeneous population of monomeric nanocrystals, of a very small size, about 7 nm to about 12 nm in diameter. The method comprises mixing a nanocrystal coated with weakly binding ligands or ions with a polymer in a solution and incubating at a temperature greater than about 100° C., thereby forming a quantum dot having a substantially homogenous population of monomeric nanocrystals. The quantum dots can be further conjugated to bioaffinity molecules, enabling broad utilization of compact, biofunctional quantum dots for studying crowded macromolecular environments.
FILED	Tuesday, July 25, 2017
APPL NO	15/658485
ART UNIT	1641 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) B82Y 15/00 (20130101) B82Y 40/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 19/007 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/84 (20130101) C01P 2002/86 (20130101) C01P 2004/64 (20130101) Peptides C07K 2/00 (20130101) C07K 16/18 (20130101) C07K 2317/569 (20130101) C07K 2319/21 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/533 (20130101) G01N 33/587 (20130101) G01N 33/588 (20130101) Original (OR) Class G01N 33/54346 (20130101)
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11226474 — Reverberation microscopy systems and methods

US 11226474	Mertz et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC)
APPLICANT(S)	Trustees of Boston University (Boston, Massachusetts)
ASSIGNEE(S)	TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts)
INVENTOR(S)	Jerome Charles Mertz (Newton, Massachusetts); Devin Robert Beaulieu (Brookline, Massachusetts); Thomas Gary Bifano (Mansfield, Massachusetts)
ABSTRACT	A method for obtaining one or more images of a sample using a microscope includes dividing, using a reverberation cavity, a first one of a plurality of laser pulses into a plurality of sequential sub-pulses, each of the plurality of sequential sub-pulses having a power that is less than a previous one of the plurality of sequential sub-pulses, directing, using the one or more lenses of the microscope, the plurality of sequential sub-pulses onto a portion of the sample to generate a plurality of signals, each of the plurality of signals being associated with a different depth within the sample, and detecting the plurality of signals from the sample to generate one or more images of at least a portion of the sample.
FILED	Thursday, April 23, 2020
APPL NO	16/856941
ART UNIT	2886 — Optics
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6402 (20130101) G01N 21/6458 (20130101) G01N 2201/06113 (20130101) Optical Elements, Systems, or Apparatus G02B 21/0032 (20130101) Original (OR) Class G02B 21/0048 (20130101) G02B 21/0076 (20130101)
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11226479 — Electrowetting prism for scanning in high resolution fluorescence microscopy

US 11226479	Gopinath et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR) National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Biological Infrastructure (DBI) Directorate for Engineering (ENG) Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF COLORADO (Denver, Colorado)
ASSIGNEE(S)	The Regents of the University of Colorado (Denver, Colorado)
INVENTOR(S)	Juliet T. Gopinath (Boulder, Colorado); Victor M. Bright (Boulder, Colorado); Omkar D. Supekar (Boulder, Colorado); Wei Yang Lim (Boulder, Colorado); Mo Zohrabi (Boulder, Colorado)
ABSTRACT	A system for high resolution multiphoton excitation microscopy is described herein. In one embodiment, the system may include an electrowetting on dielectric (EWOD) prism optically coupled to an excitation source, the EWOD prism adapted or configured to: receive a light beam from the excitation source, and project the received light beam onto a sample plane based on a tunable transmission angle of the EWOD prism, and a fluorescence imaging microscope adapted or configured to: receive a fluorescence signal from the sample plane based on the projected light beam, and relay the fluorescence signal from the sample plane to a set of detectors.
FILED	Wednesday, May 15, 2019
APPL NO	16/413395
ART UNIT	2884 — Optics
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6458 (20130101) Optical Elements, Systems, or Apparatus G02B 3/12 (20130101) G02B 21/0076 (20130101) G02B 26/02 (20130101) G02B 26/005 (20130101) Original (OR) Class
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11227056 — Inhibiting memory disclosure attacks using destructive code reads

US 11227056	Tang et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computing and Communication Foundations (CCF)
APPLICANT(S)	Adrian Tang (New York, New York); Salvatore Stolfo (New York, New York); Lakshminarasimhan Sethumadhavan (New York, New York)
ASSIGNEE(S)	The Trustees of Columbia University in the City of New York (New York, New York)
INVENTOR(S)	Adrian Tang (New York, New York); Salvatore Stolfo (New York, New York); Lakshminarasimhan Sethumadhavan (New York, New York)
ABSTRACT	Disclosed are devices, systems, apparatus, methods, products, and other implementations, including a method that includes determining whether an operation to access a memory location containing executable code comprises a general-purpose memory access operation, and changing content of the memory location in response to a determination that the operation to access the memory location containing the executable code comprises the general-purpose memory access operation to the memory location.
FILED	Thursday, August 04, 2016
APPL NO	15/753270
ART UNIT	2433 — Cryptography and Security
CURRENT CPC	Electric Digital Data Processing G06F 9/45558 (20130101) G06F 12/1009 (20130101) G06F 12/1475 (20130101) G06F 21/52 (20130101) G06F 21/604 (20130101) G06F 21/6218 (20130101) Original (OR) Class G06F 2009/45583 (20130101) G06F 2009/45595 (20130101)
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11227671 — Methods and apparatus for double-integration orthogonal space tempering

US 11227671	Yang et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Molecular and Cellular Biosciences (MCB)
APPLICANT(S)	The Florida State University Research Foundation, Inc. (Tallahassee, Florida)
ASSIGNEE(S)	The Florida State University Research Foundation, Inc. (Tallahassee, Florida)
INVENTOR(S)	Wei Yang (Tallahassee, Florida); Lianqing Zheng (Tallahassee, Florida)
ABSTRACT	The orthogonal space random walk (OSRW) algorithm is generalized to be the orthogonal space tempering (OST) method via the introduction of the orthogonal space sampling temperature. Moreover, a double-integration recursion method is developed to enable practically efficient and robust OST free energy calculations, and the algorithm is augmented by a novel θ-dynamics approach to realize both the uniform sampling of order parameter spaces and rigorous end point constraints. In the present work, the double-integration OST method is employed to perform alchemical free energy simulations, specifically to calculate the free energy difference between benzyl phosphonate and difluorobenzyl phosphonate in aqueous solution, to estimate the solvation free energy of the octanol molecule, and to predict the nontrivial Barnase-Barstar binding affinity change induced by the Barnase N58A mutation. As demonstrated in these model studies, the DI-OST method can robustly enable practically efficient free energy predictions, particularly when strongly coupled slow environmental transitions are involved.
FILED	Wednesday, May 16, 2018
APPL NO	15/981528
ART UNIT	1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) G16B 5/30 (20190201) Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 10/00 (20190201) Original (OR) Class G16C 20/50 (20190201) G16C 20/90 (20190201)
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11227758 — Apparatus and method for capturing ions in an electrostatic linear ion trap

US 11227758	Jarrold
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Indiana)
ASSIGNEE(S)	The Trustees Of Indiana University (Bloomington, Indiana)
INVENTOR(S)	Martin F. Jarrold (Bloomington, Indiana)
ABSTRACT	A system for trapping ions for measurement thereof may include an electrostatic linear ion trap (ELIT), a source of ions to supply ions to the ELIT, a processor operatively coupled to ELIT, and a memory having instructions stored therein executable by the processor to produce at least one control signal to open the ELIT to allow ions supplied by the source of ions to enter the ELIT, determine an ion inlet frequency corresponding to a frequency of ions flowing from the source of ions into the open ELIT, generate or receive a target ion charge value, determine an optimum threshold value as a function of the target ion charge value and the determined ion inlet frequency, and produce at least one control signal to close the ELIT when a charge of an ion within the ELIT exceeds the optimum threshold value to thereby trap the ion in the ELIT.
FILED	Friday, January 11, 2019
APPL NO	17/058556
ART UNIT	2881 — Optics
CURRENT CPC	Electric Discharge Tubes or Discharge Lamps H01J 49/022 (20130101) H01J 49/025 (20130101) H01J 49/0031 (20130101) H01J 49/406 (20130101) H01J 49/426 (20130101) H01J 49/4245 (20130101) Original (OR) Class
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11227759 — Ion trap array for high throughput charge detection mass spectrometry

US 11227759	Jarrold et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Indiana)
ASSIGNEE(S)	The Trustees of Indiana University (Bloomington, Indiana)
INVENTOR(S)	Martin F. Jarrold (Bloomington, Indiana); Daniel Botamanenko (Bloomington, Indiana)
ABSTRACT	An electrostatic linear ion trap (ELIT) array includes multiple elongated charge detection cylinders arranged end-to-end and each defining an axial passageway extending centrally therethrough, a plurality of ion mirror structures each defining a pair of axially aligned cavities and an axial passageway extending centrally therethrough, wherein a different ion mirror structure is disposed between opposing ends of each cylinder, and front and rear ion mirrors each defining at least one cavity and an axial passageway extending centrally therethrough, the front ion mirror positioned at one end of the arrangement of charge detection cylinders and the rear ion mirror positioned at an opposite end of the arrangement of charge detection cylinders, wherein the axial passageways of the charge detection cylinders, the ion mirror structures, the front ion mirror and the rear ion mirror are coaxial to define a longitudinal axis passing centrally through the ELIT array. In a second aspect, an ELIT array comprises a plurality of non-coaxial ELIT regions, wherein ions are selectively guided into each of the ELIT regions.
FILED	Friday, January 11, 2019
APPL NO	17/058561
ART UNIT	2881 — Optics
CURRENT CPC	Electric Discharge Tubes or Discharge Lamps H01J 49/022 (20130101) H01J 49/025 (20130101) H01J 49/0031 (20130101) H01J 49/0036 (20130101) H01J 49/406 (20130101) H01J 49/426 (20130101) H01J 49/4245 (20130101) Original (OR) Class
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11228477 — Devices, systems, and methods employing polynomial symbol waveforms

US 11228477	Prothero et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	Astrapi Corporation (Dallas, Texas)
ASSIGNEE(S)	Astrapi Corporation (Dallas, Texas)
INVENTOR(S)	Jerrold Prothero (Delray Beach, Florida); James J. Sterling (Chambersburg, Pennsylvania)
ABSTRACT	Systems, devices, and methods of the present invention enhance data transmission through the use of polynomial symbol waveforms (PSW) and sets of PSWs corresponding to a symbol alphabet is here termed a PSW alphabet. Methods introduced here are based on modifying polynomial alphabet by changing the polynomial coefficients or roots of PSWs and/or shaping of the polynomial alphabet, such as by polynomial convolution, to produce a designed PSW alphabet including waveforms with improved characteristics for data transmission.
FILED	Thursday, October 01, 2020
APPL NO	17/060181
ART UNIT	2637 — Optical Communications
CURRENT CPC	Transmission of Digital Information, e.g Telegraphic Communication H04L 27/363 (20130101) H04L 27/2639 (20130101) H04L 27/2647 (20130101) H04L 27/3405 (20130101) Original (OR) Class H04L 27/3494 (20130101)
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11228517 — Device fingerprinting for cyber-physical systems

US 11228517	Beyah et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	Georgia Tech Research Corporation (Atlanta, Georgia)
ASSIGNEE(S)	GEORGIA TECH RESEARCH CORPORATION (Atlanta, Georgia)
INVENTOR(S)	Abul Raheem Beyah (Atlanta, Georgia); David Formby (Atlanta, Georgia); Preethi Srinivasan (Atlanta, Georgia)
ABSTRACT	Disclosed are various embodiments for identifying devices that are part of a network. Devices are modeled based on physical characteristics. Devices are classified or device communications can be verified.
FILED	Thursday, September 26, 2019
APPL NO	16/583988
ART UNIT	2451 — Computer Networks
CURRENT CPC	Electric Digital Data Processing G06F 15/16 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 43/065 (20130101) H04L 43/0876 (20130101) Original (OR) Class H04L 63/0876 (20130101) H04L 63/1408 (20130101)
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National Aeronautics and Space Administration (NASA)

11226045 — Debris tolerant valve

US 11226045	Richard et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	United States of America as represented by the Administrator of NASA (Washington, District of Columbia)
ASSIGNEE(S)	United States of America as represented by the Administrator of NASA (Washington, District of Columbia)
INVENTOR(S)	James A. Richard (Grant, Alabama); Christopher T. Griffith (Decatur, Alabama)
ABSTRACT	A valve includes a valve body, a sleeve within the valve body and a rotatable valve element that has one portion within the sleeve to control flow of media through the valve and another portion extending from the valve body and coupled to an actuator that rotates the valve element. The valve element is rotatable to a first position to flow media to one port and to a second position to flow media to another port. The sleeve has a pair of side openings. Each side opening has an angled perimetrical edge and is aligned with a corresponding port member. A half dovetail shaped groove is formed by the angled perimetrical edge of each side opening, the corresponding port and the valve body. A seal is lodged within each groove to form a seal that exhibits reduced unswept volume and which wipes debris off the valve element as it rotates.
FILED	Friday, November 22, 2019
APPL NO	16/692857
ART UNIT	3753 — Fluid Handling and Dispensing
CURRENT CPC	Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 11/02 (20130101) Original (OR) Class F16K 15/144 (20130101) F16K 31/40 (20130101) F16K 31/046 (20130101)
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11226538 — Thin-film optical parametric oscillators

US 11226538	Marandi et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) Jet Propulsion Laboratory (JPL)
APPLICANT(S)	California Institute of Technology (Pasadena, California)
ASSIGNEE(S)	California Institute of Technology (Pasadena, California)
INVENTOR(S)	Alireza Marandi (Pasadena, California); Luis Ledezma (La Crescenta, California); Yinglun Xu (Wuhan, China PRC); Ryan M. Briggs (Pasadena, California)
ABSTRACT	An optical parametric oscillator (OPO) including a thin film waveguide including a material having a second order nonlinear susceptibility generating an electromagnetic wave in response to pump electromagnetic wave inputted into the thin film waveguide. The electromagnetic wave has a first wavelength or first set of wavelengths longer than a second wavelength or second set of wavelengths of the pump electromagnetic wave. The thin film waveguide has a thickness on the order of the first wavelength or the first set of wavelengths in the thin film waveguide so as to guide the output electromagnetic wave along the thin film waveguide.
FILED	Monday, March 09, 2020
APPL NO	16/813462
ART UNIT	2874 — Optics
CURRENT CPC	Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/39 (20130101) Original (OR) Class G02F 1/392 (20210101) G02F 1/3542 (20210101) G02F 2203/15 (20130101)
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11229113 — Discharge cell systems and methods

US 11229113	Starikovskiy et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	METROLASER, INC. (Laguna Hills, California)
ASSIGNEE(S)	MetroLaser, Inc. (Laguna Hills, California); The Trustees of Princeton University (Princeton, New Jersey)
INVENTOR(S)	Andrey Y. Starikovskiy (Plainsboro, New Jersey); Jacob George (Downey, California); Richard B. Miles (College Station, Texas)
ABSTRACT	Described herein are systems and methods for ensuring plasma homogeneity in a discharge cell. The discharge cell may include a first hollow electrode and a second hollow electrode spaced away from the first electrode to define a discharge gap therebetween. A fluid inlet port may in fluid communication with an internal bore of the first electrode. A fluid outlet port may be in fluid communication with the discharge gap. A first pair of viewports may define a first optic pathway through the discharge gap. A second pair of viewports may define a second optic pathway through the discharge gap. A third pair of viewports may define a third optic pathway through the discharge gap, the third optic pathway defined through the hollow interior of the first and second electrodes.
FILED	Wednesday, August 12, 2020
APPL NO	16/991922
ART UNIT	2879 — Optics
CURRENT CPC	Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 1/48 (20130101) Original (OR) Class
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Small Business Administration (SBA)

11225475 — Substituted pyridines as inhibitors of histone deacetylase

US 11225475	Fuller et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Aging (NIA) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Alkermes, Inc. (Waltham, Massachusetts)
ASSIGNEE(S)	Alkermes, Inc. (Waltham, Massachusetts)
INVENTOR(S)	Nathan Oliver Fuller (Arlington, Massachusetts); John A. Lowe, III (Stonington, Connecticut)
ABSTRACT	Provided herein are compounds and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of conditions associated with inhibition of HDAC (e.g., HDAC2).
FILED	Tuesday, August 07, 2018
APPL NO	16/636969
ART UNIT	1624 — Organic Chemistry
CURRENT CPC	Heterocyclic Compounds C07D 471/04 (20130101) Original (OR) Class C07D 487/04 (20130101) C07D 513/04 (20130101)
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11225479 — Bicyclic inhibitors of histone deacetylase

US 11225479	Fuller et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Aging (NIA) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Alkermes, Inc. (Waltham, Massachusetts)
ASSIGNEE(S)	Alkermes, Inc. (Waltham, Massachusetts)
INVENTOR(S)	Nathan Oliver Fuller (Arlington, Massachusetts); John A. Lowe, III (Stonington, Connecticut)
ABSTRACT	Provided herein are compounds and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of conditions associated with inhibition of HDAC (e.g., HDAC2).
FILED	Monday, August 31, 2020
APPL NO	17/007151
ART UNIT	1699 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/437 (20130101) A61K 31/519 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Heterocyclic Compounds C07D 471/04 (20130101) Original (OR) Class C07D 487/04 (20130101)
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11229113 — Discharge cell systems and methods

US 11229113	Starikovskiy et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	METROLASER, INC. (Laguna Hills, California)
ASSIGNEE(S)	MetroLaser, Inc. (Laguna Hills, California); The Trustees of Princeton University (Princeton, New Jersey)
INVENTOR(S)	Andrey Y. Starikovskiy (Plainsboro, New Jersey); Jacob George (Downey, California); Richard B. Miles (College Station, Texas)
ABSTRACT	Described herein are systems and methods for ensuring plasma homogeneity in a discharge cell. The discharge cell may include a first hollow electrode and a second hollow electrode spaced away from the first electrode to define a discharge gap therebetween. A fluid inlet port may in fluid communication with an internal bore of the first electrode. A fluid outlet port may be in fluid communication with the discharge gap. A first pair of viewports may define a first optic pathway through the discharge gap. A second pair of viewports may define a second optic pathway through the discharge gap. A third pair of viewports may define a third optic pathway through the discharge gap, the third optic pathway defined through the hollow interior of the first and second electrodes.
FILED	Wednesday, August 12, 2020
APPL NO	16/991922
ART UNIT	2879 — Optics
CURRENT CPC	Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 1/48 (20130101) Original (OR) Class
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Department of Agriculture (USDA)

11224237 — Low fiber pennycress meal, seeds, and methods of making

US 11224237	Ulmasov et al.
FUNDED BY	Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA)
APPLICANT(S)	COVERCRESS INC. (St. Louis, Missouri); BOARD OF TRUSTEES OF ILLINOIS STATE UNIVERSITY (Normal, Illinois); REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota)
ASSIGNEE(S)	Covercress Inc. (St. Louis, Missouri); Board of Trustees of Illinois State University (Normal, Illinois); Regents of the University of Minnesota (Minneapolis, Minnesota)
INVENTOR(S)	Tim Ulmasov (St. Louis, Missouri); Cristine Handel (St. Louis, Missouri); Gary Hartnell (St. Peters, Missouri); John C. Sedbrook (Bloomington, Illinois); Michael David Marks (Roseville, Minnesota); Ratan Chopra (St. Paul, Minnesota); Maliheh Esfahanian (Bloomington, Illinois)
ABSTRACT	Pennycress seed, seed lots, and seed meal having reduced fiber content and improved suitability for use in producing animal feed are provided.
FILED	Friday, June 05, 2020
APPL NO	16/893636
ART UNIT	1662 — Plants
CURRENT CPC	Fodder A23K 10/30 (20160501) Original (OR) Class A23K 20/158 (20160501)
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11227142 — Culture imaging system

US 11227142	Robinson et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) Department of Agriculture (USDA)
APPLICANT(S)	Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S)	Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S)	Joseph Paul Robinson (West Lafayette, Indiana); Bartlomiej P. Rajwa (West Lafayette, Indiana); Kathryn E. Ragheb (West Lafayette, Indiana); Cheryl M. Holdman (Brookston, Indiana); Valery P. Patsekin (West Lafayette, Indiana); Euiwon Bae (West Lafayette, Indiana); Jennifer Sturgis (West Lafayette, Indiana)
ABSTRACT	A system for the characterization of a colony of microorganisms includes a coherent light source configured to provide coherent light of one or more wavelengths along a common optical path. A holder is configured to operationally arrange a substrate so that the colony of microorganisms on a surface of the substrate is positioned to receive the coherent light. Scattered light is generated from the colony of microorganisms receiving coherent light. A first image capture device is configured to receive the scattered light and generate a scatter image from the microorganism colony irradiated by the coherent light. The system also includes a magnifying lens configured to magnify the colony of microorganisms. A second image capture device is configured to capture a light image of the colony of microorganisms magnified by the magnifying lens. Methods of assigning organisms to categories with like organisms without necessarily identifying the organisms are also described.
FILED	Friday, June 12, 2020
APPL NO	16/900841
ART UNIT	2668 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Apparatus for Enzymology or Microbiology; C12M 41/36 (20130101) Optical Elements, Systems, or Apparatus G02B 21/365 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/0014 (20130101) G06K 9/00134 (20130101) G06K 9/00147 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/10056 (20130101) G06T 2207/30024 (20130101)
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Department of Commerce (DOC)

11225731 — Large aluminum nitride crystals with reduced defects and methods of making them

US 11225731	Bondokov et al.
FUNDED BY	Department of Commerce (DOC) National Institute of Standards and Technology (NIST)
APPLICANT(S)	Robert Bondokov (Watervliet, New York); Kenneth E. Morgan (Castleton, New York); Glen A. Slack (Scotia, New York); Leo J. Schowalter (Latham, New York)
ASSIGNEE(S)	CRYSTAL IS, INC. (Green Island, New York)
INVENTOR(S)	Robert Bondokov (Watervliet, New York); Kenneth E. Morgan (Castleton, New York); Glen A. Slack (Scotia, New York); Leo J. Schowalter (Latham, New York)
ABSTRACT	Reducing the microvoid (MV) density in AlN ameliorates numerous problems related to cracking during crystal growth, etch pit generation during the polishing, reduction of the optical transparency in an AlN wafer, and, possibly, growth pit formation during epitaxial growth of AlN and/or AlGaN. This facilitates practical crystal production strategies and the formation of large, bulk AlN crystals with low defect densities—e.g., a dislocation density below 10⁴cm⁻²and an inclusion density below 10⁴cm⁻³and/or a MV density below 10⁴cm⁻³.
FILED	Wednesday, February 08, 2017
APPL NO	15/427619
ART UNIT	1714 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC	Working Stone or Stone-like Materials B28D 5/00 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/34 (20130101) Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 23/00 (20130101) C30B 23/02 (20130101) C30B 25/02 (20130101) C30B 25/08 (20130101) C30B 25/10 (20130101) C30B 25/18 (20130101) C30B 29/403 (20130101) C30B 33/02 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0201 (20130101) H01L 21/0254 (20130101) H01L 21/02389 (20130101) H01L 21/30625 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/21 (20150115)
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11226534 — Methods and apparatus for generating mid-infrared frequency combs

US 11226534	Diddams et al.
FUNDED BY	Department of Commerce (DOC) National Institute of Standards and Technology (NIST) Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	The Regents of the University of Colorado (Denver, Colorado)
ASSIGNEE(S)	Fathom Radiant, PBC (Boulder, Colorado)
INVENTOR(S)	Scott Diddams (Louisville, Colorado); Henry Timmers (Golden, Colorado); Abijith J. Kowligy (Boulder, Colorado); Alexander Jacob Lind (Boulder, Colorado); Scott Papp (Boulder, Colorado)
ABSTRACT	Apparatus and methods for generating mid-IR frequency combs using intra-pulse DFG. A mode-locked pulse generation laser generates near-IR pulses which are amplified. The amplified pulses are spectrally broadened by a nonlinear element, for example a normal dispersion highly nonlinear fiber (ND-HNLF) to generate broadened pulses. The nonlinear spectral broadening element is a transparent dielectric material having a cubic nonlinear response. Broadened pulses are temporally compressed to generate short, high-power pulses which few-cycle conditioned pulses which are ready for the intrapulse DFG process. The DFG block generates a mid-IR comb by difference frequency generation. It might comprise an orientation patterned GaP (OP-GaP) crystal or a poled lithium niobate (PPLN) crystal.
FILED	Wednesday, August 21, 2019
APPL NO	16/546890
ART UNIT	2874 — Optics
CURRENT CPC	Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/365 (20130101) G02F 1/3501 (20130101) Original (OR) Class G02F 1/3503 (20210101) G02F 1/3551 (20130101) G02F 2203/56 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/1671 (20130101)
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Classified Government Agency

11226436 — Method for co-locating dissimilar optical systems in a single aperture

US 11226436	Jew et al.
FUNDED BY	Classified Government Agency
APPLICANT(S)	BAE SYSTEMS Information and Electronic Systems Integration Inc. (Nashua, New Hampshire)
ASSIGNEE(S)	BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire)
INVENTOR(S)	Jeffrey L. Jew (Brookline, New Hampshire); Ian B. Murray (Amherst, New Hampshire); Michael J. Shaw (Epsom, New Hampshire)
ABSTRACT	The system and method for combining two optical assemblies into the same volume, particularly when the field of view of the two assemblies are different, so that the overall volume and size, weight and power (SWaP) for the system is reduced. This also allows both subsystems (e.g., narrow field of view (NFOV) and wide field of view (WFOV) to use a single aperture and the same external protective window, reducing overall cost for a system of co-located dissimilar optical systems in a single aperture.
FILED	Wednesday, December 18, 2019
APPL NO	16/718608
ART UNIT	2872 — Optics
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 3/0068 (20130101) G02B 5/045 (20130101) Original (OR) Class
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National Reconnaissance Office (NRO)

11227162 — Multilayer information dynamics for activity and behavior detection

US 11227162	Lu et al.
FUNDED BY	National Reconnaissance Office (NRO)
APPLICANT(S)	HRL Laboratories, LLC (Malibu, California)
ASSIGNEE(S)	HRL Laboratories, LLC (Malibu, California)
INVENTOR(S)	Tsai-Ching Lu (Thousand Oaks, California); Kang-Yu Ni (Calabasas, California); Ryan M. Uhlenbrock (Calabasas, California)
ABSTRACT	Described is a system for activity and behavior detection in a target system. Raw data extracted from various heterogeneous sources of the target system is fused across spatial and temporal scales into a multi-graph representation. Information flows of the multi-graph representation are analyzed using a set of multi-layer information dynamic measures. Based on the set of multi-layer information dynamic measures, at least one of an economic and social indicator of emerging activity of interest in the target system is derived. The indicator is then used for prediction of future activity of interest in the target system.
FILED	Tuesday, April 25, 2017
APPL NO	15/497202
ART UNIT	2126 — AI & Simulation/Modeling
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/103 (20130101) Electric Digital Data Processing G06F 15/00 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/62 (20130101) G06K 9/00771 (20130101) Original (OR) Class G06K 9/6292 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 30/02 (20130101) G06Q 99/00 (20130101) Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 13/19615 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

National Security Agency (NSA)

11227967 — Optoelectronic component with current deflected to high-gain paths comprising a three-terminal avalanche photodiode having an insulating layer between absorbing region and a leakage path

US 11227967	Zeng et al.
FUNDED BY	National Security Agency (NSA)
APPLICANT(S)	Hewlett Packard Enterprise Development LP (Houston, Texas)
ASSIGNEE(S)	Hewlett Packard Enterprise Development LP (Houston, Texas)
INVENTOR(S)	Xiaoge Zeng (Milpitas, California); Zhihong Huang (Milpitas, California); Di Liang (Santa Barbara, California)
ABSTRACT	A three-terminal avalanche photodiode provides a first controllable voltage drop across a light absorbing region and a second, independently controllable, voltage drop across a photocurrent amplifying region. The absorbing region may also have a different composition from the amplifying region, allowing further independent optimization of the two functional regions. An insulating layer blocks leakage paths, redirecting photocurrent toward the region(s) of highest avalanche gain. The resulting high-gain, low-bias avalanche photodiodes may be fabricated in integrated optical circuits using commercial CMOS processes, operated by power supplies common to mature computer architecture, and used for optical interconnects, light sensing, and other applications.
FILED	Thursday, November 12, 2020
APPL NO	16/949723
ART UNIT	2878 — Optics
CURRENT CPC	Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 1/44 (20130101) G01J 2001/4466 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/1075 (20130101) Original (OR) Class H01L 31/1804 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

United States Postal Service (USPS)

11226640 — System and method of control of electronic parcel lockers

US 11226640	Irwin et al.
FUNDED BY	United States Postal Service (USPS)
APPLICANT(S)	United States Postal Service (Washington, District of Columbia)
ASSIGNEE(S)	United States Postal Service (Washington, District of Columbia)
INVENTOR(S)	Donald E. Irwin (Fredericksburg, Virginia); Nan K. McKenzie (Garrett Park, Maryland); William A. Tartal (Baltimore, Maryland); Victoria K. Stephen (Burke, Virginia); Michael J. Amato (Reston, Virginia)
ABSTRACT	A system, apparatus, and method for use in delivery of items to a storage unit. The storage unit can include one or several storage receptacles and a control unit that controls and monitors the status of the one or several storage receptacles. The storage unit may be included in a storage unit system that can include one or several storage units and a central control unit. The central control unit can communicate with the one or several storage units, and can receive status and availability updates from the one or several storage units.
FILED	Wednesday, March 21, 2018
APPL NO	15/927552
ART UNIT	3637 — Static Structures, Supports and Furniture
CURRENT CPC	Transport or Storage Devices, e.g Conveyors for Loading or Tipping, shop Conveyor Systems Or pneumatic Tube Conveyors B65G 1/0485 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 3/00 (20130101) Original (OR) Class Electric Digital Data Processing G06F 17/00 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/0836 (20130101) Coin-freed or Like Apparatus G07F 7/08 (20130101) G07F 17/10 (20130101) G07F 17/12 (20130101) G07F 17/13 (20200501)
VIEW PATENT	@ USPTO: Full Text PDF

Government Rights Acknowledged

How To Use This Page

What You'll Find On This Page

THE FEDINVENT PATENT DETAILS PAGE

Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.

This week's information is published in the FedInvent Patents report for Tuesday, January 18, 2022.

The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week’s taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.

HOW IS THE INFORMATION ORGANIZED?

Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.

WHAT INFORMATION WILL I FIND?

THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:

FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:

Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)

We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.

APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.

Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer funded innovation is happening in America. Here are two examples from two different patents:

APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC

APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)

INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.

ABSTRACT
The abstract as it appears on the patent.

FILED
The date of the patent application including the day of the week.

APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.

ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:

3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices

You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.

CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.

The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.

The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.

A61B 1/149 (20130101)
A61B 1/71 (20130101)
A61B 1/105 (20130101)

The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full-text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.

VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.

HOW DO I FIND A SPECIFIC PATENT ON A PAGE?

You can use the Command F or Control F to find a specific patent you are interested in.

HOW DO I GET HERE?

You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.

You can also reach this page using the weekly page link that looks like this:

https://wayfinder.digital/fedinvent/patents-2021/details-patents-20210427.html

Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.

Download a copy of the How To Use This Page

HAVE MORE QUESTIONS?

info@wayfinder.digital