FedInvent™ Patents

Patent Details for Tuesday, June 07, 2022

This page was updated on Friday, June 10, 2022 at 08:02 AM GMT

Department of Health and Human Services (HHS)

11350820 — Grading corneal fluorescein staining

US 11350820	Dana et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI)
APPLICANT(S)	Massachusetts Eye and Ear Infirmary (Boston, Massachusetts)
ASSIGNEE(S)	Massachusetts Eye and Ear Infirmary (Boston, Massachusetts)
INVENTOR(S)	Reza Dana (Newton, Massachusetts); Francisco L. Amparo Pulido (Cambridge, Massachusetts); Haobing Wang (Newton, Massachusetts)
ABSTRACT	The technology described in this document can be embodied in systems and computer-implemented methods for determining a score representing an amount of staining of the cornea. The methods include obtaining a digital image of the cornea stained with a tracer material, receiving a selection of a portion of the image, and processing, by a processing device, the selection to exclude areas with one or more artifacts to define an evaluation area. For each of a plurality of pixels within the evaluation area, a plurality of Cartesian color components are determined and a hue value in a polar coordinate based color space is calculated from the components. An amount of staining of the cornea is then determined as a function of the hue value. The methods also include assigning a score to the evaluation area based on the amount of staining calculated for the plurality of pixels.
FILED	Monday, December 02, 2019
APPL NO	16/700575
ART UNIT	2872 — Optics
CURRENT CPC	Diagnosis; Surgery; Identification A61B 3/14 (20130101) A61B 3/0025 (20130101) Original (OR) Class A61B 3/1025 (20130101) A61B 5/0071 (20130101) A61B 5/1032 (20130101) A61B 5/4848 (20130101)
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11350844 — System and method for generating nonalcoholic fatty liver disease activity score (NAS) using magnetic resonance elastography

US 11350844	Yin et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (Rochester, Minnesota)
ASSIGNEE(S)	Mayo Foundation for Medical Education and Research (Rochester, Minnesota)
INVENTOR(S)	Meng Yin (Rochester, Minnesota); Richard L. Ehman (Rochester, Minnesota); Alina Allen (Rochester, Minnesota); Vijay H. Shah (Rochester, Minnesota); Sudhakar K. Venkatesh (Rochester, Minnesota); Taofic Mounajjed (Rochester, Minnesota)
ABSTRACT	The present disclosure relates to a system and method for non-invasively determining NAFLD activity scores (NAS) in patients using mechanical properties determined through magnetic resonance elastography (MRE) imaging. The non-invasively determined NAS score is then used to diagnose NFALD and NASH patients.
FILED	Tuesday, November 21, 2017
APPL NO	15/819160
ART UNIT	3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/004 (20130101) A61B 5/0022 (20130101) A61B 5/0051 (20130101) A61B 5/055 (20130101) Original (OR) Class A61B 5/318 (20210101) A61B 5/748 (20130101) A61B 5/0816 (20130101) A61B 5/4244 (20130101) A61B 5/7278 (20130101) A61B 5/7282 (20130101) A61B 5/7285 (20130101) A61B 2576/02 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/30 (20130101) G01R 33/56358 (20130101) Image Data Processing or Generation, in General G06T 11/006 (20130101)
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11350854 — Augmented neuromuscular training system and method

US 11350854	Myer et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S)	Children's Hospital Medical Center (Cincinnati, Ohio); University of Cincinnati (Cincinnati, Ohio)
ASSIGNEE(S)	Children's Hospital Medical Center (Cincinnati, Ohio); University of Cincinnati (Cincinnati, Ohio)
INVENTOR(S)	Gregory Donald Myer (Cincinnati, Ohio); Michael Alan Riley (Cincinnati, Ohio); Adam Charles Kiefer (Cincinnati, Ohio)
ABSTRACT	An augmented neuromuscular training system and method for providing feedback to a user in order to reduce movement deficits associated with injury risk, prior injury or disease pathology.
FILED	Monday, November 13, 2017
APPL NO	15/811513
ART UNIT	3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/486 (20130101) A61B 5/742 (20130101) A61B 5/744 (20130101) A61B 5/1071 (20130101) A61B 5/1107 (20130101) A61B 5/1114 (20130101) A61B 5/1116 (20130101) A61B 5/1118 (20130101) A61B 5/1121 (20130101) Original (OR) Class A61B 5/1122 (20130101) A61B 5/1124 (20130101) A61B 5/1127 (20130101) A61B 5/1128 (20130101) A61B 5/4533 (20130101) A61B 5/4538 (20130101) A61B 5/4585 (20130101) A61B 5/6803 (20130101) A61B 5/6814 (20130101) A61B 5/7445 (20130101)
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11350870 — Method of identifying epileptic brain regions

US 11350870	Loeb
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
ASSIGNEE(S)	The Board of Trustees of the University of Illinois (Urbana, Illinois)
INVENTOR(S)	Jeffrey A Loeb (Chicago, Illinois)
ABSTRACT	This disclosure provides methods, reagents, and diagnostic and prognostic markers useful for non-invasive identification, diagnosis, and therapeutic intervention in individuals with epilepsy. More particularly, the disclosure uses specific metabolites measured by magnetic resonance spectroscopy in brain tissue to detect epileptic brain regions.
FILED	Wednesday, June 20, 2018
APPL NO	16/012843
ART UNIT	3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/4064 (20130101) A61B 5/4094 (20130101) Original (OR) Class A61B 5/14546 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 24/08 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/465 (20130101)
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11350888 — Risk prediction for sudden cardiac death from image derived cardiac motion and structure features

US 11350888	Krebs et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	Siemens Healthcare GmbH (Erlangen, Germany); The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S)	Siemens Healthcare GmbH (Erlangen, Germany); The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S)	Julian Krebs (Moers, Germany); Hiroshi Ashikaga (Lutherville Timonium, Maryland); Tommaso Mansi (Plainsboro, New Jersey); Bin Lou (Princeton, New Jersey); Katherine Chih-ching Wu (Bel Air, Maryland); Henry Halperin (Baltimore, Maryland)
ABSTRACT	Systems and methods for personalized sudden cardiac death risk prediction that generates fingerprints of imaging features of cardiac structure and function. One or more fingerprints and clinical data may be used to generate a risk score. The output risk score may be used to predict the time of death in order to select high-risk patients for implantable cardioverter-defibrillator treatment.
FILED	Friday, April 10, 2020
APPL NO	16/845111
ART UNIT	2664 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/4848 (20130101) A61B 5/7267 (20130101) A61B 5/7275 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/10088 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30048 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101) G16H 50/20 (20180101) G16H 50/30 (20180101)
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11350895 — System and method for spectral computed tomography using single polychromatic x-ray spectrum acquisition

US 11350895	Chen et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
INVENTOR(S)	Guang-Hong Chen (Madison, Wisconsin); Yinsheng Li (Madison, Wisconsin)
ABSTRACT	A system and method for material decomposition of a single energy spectrum x-ray dataset includes accessing the single energy spectrum x-ray dataset, receiving a user-selection of a desired energy for decomposition, and decomposing the single energy spectrum x-ray dataset into material bases as a linear combination of energy dependence function of selected basis materials and the corresponding spatial dependence material bases images.
FILED	Friday, November 29, 2019
APPL NO	16/699222
ART UNIT	2884 — Optics
CURRENT CPC	Diagnosis; Surgery; Identification A61B 6/032 (20130101) A61B 6/4241 (20130101) Original (OR) Class Measurement of Nuclear or X-radiation G01T 1/36 (20130101) Computer Systems Based on Specific Computational Models G06N 3/084 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 11/006 (20130101) G06T 2207/10072 (20130101) G06T 2207/30004 (20130101)
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11350901 — Recurrence prognosis and prediction of added benefit of adjuvant chemotherapy in early stage non-small cell lung cancer with radiomic features on baseline computed tomography

US 11350901	Madabhushi et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Army Medical Research Acquisition Activity (USAMRAA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Center for Research Resources (NCRR) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	Case Western Reserve University (Cleveland, Ohio)
ASSIGNEE(S)	Case Western Reserve University (Cleveland, Ohio); The Cleveland Clinic Foundation (Cleveland, Ohio)
INVENTOR(S)	Anant Madabhushi (Shaker Heights, Ohio); Pranjal Vaidya (Cleveland, Ohio); Vamsidhar Velcheti (Pepper Pike, Ohio); Kaustav Bera (Cleveland, Ohio)
ABSTRACT	Embodiments generate an early stage NSCLC recurrence prognosis, and predict added benefit of adjuvant chemotherapy. Embodiments include processors configured to access a radiological image of a region of tissue demonstrating early stage NSCLC; segment a tumor represented in the radiological image; define a peritumoral region based on a morphological dilation of a boundary of the tumor; extract a radiomic signature that includes a set of tumoral radiomic features extracted from the tumoral region, and a set of peritumoral radiomic features extracted from the peritumoral region, based on a continuous time to event data; compute a radiomic score based on the radiomic signature; compute a probability of added benefit of adjuvant chemotherapy based on the radiomic score; and generate an NSCLC recurrence prognosis based on the radiomic score. Embodiments may display the radiomic score, or generate a personalized treatment plan based on the radiomic score.
FILED	Tuesday, November 27, 2018
APPL NO	16/200710
ART UNIT	3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 6/12 (20130101) A61B 6/032 (20130101) A61B 6/50 (20130101) A61B 6/463 (20130101) A61B 6/5217 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/0012 (20130101) G06T 7/12 (20170101) G06T 7/136 (20170101) G06T 7/187 (20170101) G06T 2207/10081 (20130101) G06T 2207/20076 (20130101) G06T 2207/20081 (20130101) G06T 2207/20152 (20130101) G06T 2207/30061 (20130101) G06T 2207/30096 (20130101) Image or Video Recognition or Understanding G06V 10/40 (20220101) G06V 10/446 (20220101) G06V 20/695 (20220101) G06V 20/698 (20220101) G06V 2201/031 (20220101)
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11350905 — Waveform enhanced reflection and margin boundary characterization for ultrasound tomography

US 11350905	Duric et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Delphinus Medical Technologies, Inc. (Novi, Michigan)
ASSIGNEE(S)	Delphinus Medical Technologies, Inc. (Novi, Michigan)
INVENTOR(S)	Nebojsa Duric (Novi, Michigan); Peter J. Littrup (Novi, Michigan); Gursharan Singh Sandhu (Novi, Michigan); Mark Krycia (Novi, Michigan); Mark Sak (Novi, Michigan)
ABSTRACT	The present invention provides improved methods and systems for generating enhanced images of a volume of tissue. In an aspect, the method comprises receiving from a transducer, a plurality of acoustic signals derived from acoustic waveforms transmitted through the volume of tissue; generating from the acoustic signals, a first reflection rendering that characterizes sound reflection, the first reflection rendering comprising a first distribution of reflection values across a region of the volume of tissue; generating from the acoustic signals, a sound speed rendering that characterizes sound speed, the sound speed rendering comprising a distribution of sound speed values across the region; generating from the sound speed rendering, a second reflection rendering that characterizes sound reflection, the second reflection rendering comprising a second distribution of reflection values across the region; and rendering one or more combined images, based on the first reflection rendering and the second reflection rendering.
FILED	Tuesday, June 18, 2019
APPL NO	16/443993
ART UNIT	3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 8/13 (20130101) A61B 8/15 (20130101) A61B 8/085 (20130101) A61B 8/406 (20130101) A61B 8/0825 (20130101) Original (OR) Class A61B 8/5207 (20130101) A61B 8/5253 (20130101) Image Data Processing or Generation, in General G06T 5/008 (20130101) G06T 2207/10136 (20130101)
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11350907 — Single catheter system that provides both intravascular ultrasound and fluorescence lifetime imaging

US 11350907	Marcu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Laura Marcu (Davis, California); Julien Bec (Davis, California); Diego R. Yankelevich (Davis, California)
ABSTRACT	A multimodal intravascular catheter system includes a catheter with an optical channel and an electrical channel. A distal end of the catheter includes an optical element and an ultrasonic transducer, which are oriented orthogonally to a rotational axis of the catheter. A motor drive unit (MDU) is coupled to a proximal end of the catheter and includes a drive motor to rotate the catheter. The optical channel directs light from a pulsed UV laser source to the optical element, and returns an optical fluorescence signal from the optical element. A photodetector converts the returned optical fluorescence signal into an electrical fluorescence signal. An intravascular ultrasound (IVUS) processor is coupled to the ultrasonic transducer through the electrical channel, wherein the IVUS processor generates a drive signal for the ultrasound transducer, and processes echo information returned from the ultrasound transducer. Finally, a digitizer samples the electrical fluorescence signal and associated echo information.
FILED	Thursday, November 30, 2017
APPL NO	16/463306
ART UNIT	3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0035 (20130101) A61B 5/0071 (20130101) A61B 5/02007 (20130101) A61B 5/6852 (20130101) A61B 5/6876 (20130101) A61B 8/12 (20130101) Original (OR) Class A61B 8/0891 (20130101) A61B 8/4444 (20130101) A61B 8/5261 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/63 (20130101)
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11350909 — Cross amplitude modulation ultrasound pulse sequence

US 11350909	Maresca et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	California Institute of Technology (Pasadena, California)
ASSIGNEE(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
INVENTOR(S)	David Maresca (Pasadena, California); Daniel P. Sawyer (Pasadena, California); Mikhail Shapiro (Los Angeles, California)
ABSTRACT	Certain embodiments pertain to cross-amplitude modulation (xAM) ultrasound imaging methods and systems configured to excite a first subaperture of transducer elements to transmit a first ultrasound plane wave, excite a second subaperture of transducer elements to transmit a second ultrasound plane wave noncollinear to the first ultrasound plane wave, the second ultrasound plane wave axisymmetric to the first ultrasound plane wave about a bisector, and simultaneously excite both first and second subapertures to transmit first and second ultrasound plane waves to cause an acoustic pressure above a threshold along the bisector.
FILED	Wednesday, April 17, 2019
APPL NO	16/387259
ART UNIT	3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 8/14 (20130101) A61B 8/466 (20130101) A61B 8/481 (20130101) Original (OR) Class A61B 8/483 (20130101) A61B 8/4444 (20130101)
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11351130 — Prevention and reversal of inflammation induced DNA damage

US 11351130	Kelley et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	Indiana University Research and Technology Corporation (Indianapolis, Indiana)
ASSIGNEE(S)	Indiana University Research and Technology Corporation (Bloomington, Indiana)
INVENTOR(S)	Mark R. Kelley (Zionsville, Indiana); Jill Fehrenbacher (Indianapolis, Indiana)
ABSTRACT	Methods of reducing neuronal sensitivity, thereby reducing inflammation and chronic pain, in subjects having diabetes are disclosed herein. Particularly disclosed are methods of administrating the apurinic/apyrimidinic endonuclease 1 redox factor 1 (APE 1/Ref-1) inhibitor, APX3330, to enhance the DNA base excision repair (BER) pathway, thereby reducing neuronal sensitivity to inflammatory mediators and alleviating inflammatory or chronic pain.
FILED	Thursday, April 16, 2020
APPL NO	16/850436
ART UNIT	1627 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/165 (20130101) A61K 31/165 (20130101) A61K 31/192 (20130101) Original (OR) Class A61K 31/201 (20130101) A61K 31/201 (20130101) A61K 31/282 (20130101) A61K 31/555 (20130101) A61K 31/555 (20130101) A61K 33/24 (20130101) A61K 33/243 (20190101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/02 (20180101)
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11351140 — Resolvin mimetic antibodies and uses thereof

US 11351140	Freire
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Dental and Craniofacial Research (NIDCR)
APPLICANT(S)	J. Craig Venter Institute, Inc. (La Jolla, California)
ASSIGNEE(S)	J. Craig Venter Institute (La Jolla, California)
INVENTOR(S)	Marcelo Freire (Los Angeles, California)
ABSTRACT	Provided herein are compositions comprising a resolvin mimetic. Such mimetics may comprise an anti-ERV1 antibody, such as a resolvimab, or biologically-active antibody fragment thereof. Also provided herein are methods for treating or preventing an inflammatory disorder in a subject in need thereof comprising the steps of administering a therapeutically effective amount of at least one resolvin mimetic.
FILED	Thursday, May 17, 2018
APPL NO	16/611203
ART UNIT	1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/202 (20130101) Original (OR) Class A61K 39/00 (20130101) A61K 39/3955 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) Peptides C07K 14/705 (20130101) C07K 16/28 (20130101) C07K 19/00 (20130101) C07K 2317/56 (20130101) C07K 2317/75 (20130101) C07K 2317/622 (20130101)
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11351142 — Composition and method for treating neuronal ceroid lipofuscinosis

US 11351142	Pahan
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Complementary and Integrative Health (NCCIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	Rush University Medical Center (Chicago, Illinois)
ASSIGNEE(S)	Rush University Medical Center (Chicago, Illinois)
INVENTOR(S)	Kalipada Pahan (Skokie, Illinois)
ABSTRACT	Provided herein are methods for treatment of a neurodegenerative disease, such as neuronal ceroid lipofuscinosis including administering to a subject in need of such treatment a composition comprising a therapeutically effective amount of an agent that mediates upregulation of TPP1.
FILED	Thursday, July 18, 2019
APPL NO	16/515836
ART UNIT	1629 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/192 (20130101) A61K 31/192 (20130101) A61K 31/203 (20130101) A61K 31/203 (20130101) A61K 31/216 (20130101) Original (OR) Class A61K 31/216 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101)
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11351144 — Compounds for inhibiting secretory leukocyte protease inhibitor (SLPI)

US 11351144	Garkavtsev et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The General Hospital Corporation (Boston, Massachusetts)
ASSIGNEE(S)	The General Hospital Corporation (Boston, Massachusetts)
INVENTOR(S)	Igor Garkavtsev (Cambridge, Massachusetts); Rakesh K. Jain (Wellesley, Massachusetts)
ABSTRACT	This invention relates to compounds that are useful for inhibiting the secretion of secretory leukocyte protease inhibitor (SLPI) in a subject. Methods of inhibiting metastasis of cancer and methods of treating cancer in a subject are also provided.
FILED	Tuesday, October 09, 2018
APPL NO	16/754912
ART UNIT	1629 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/245 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101)
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11351147 — Short syntheses of (−)-picrotoxinin and related compounds

US 11351147	Crossley et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	The Scripps Research Institute (La Jolla, California)
ASSIGNEE(S)	THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California)
INVENTOR(S)	Steven W. M. Crossley (Kensington, California); Guanghu Tong (San Diego, California); Michael Lambrecht (Burlingame, California); Ryan Shenvi (San Diego, California)
ABSTRACT	The present disclosure relates to concise processes for making (−)-picrotoxinin (1, PXN) and 5-methyl-picrotoxinin (20, 5MePXN), and to 5MePXN, its pharmaceutical compositions, and its method of use for inhibiting GABA_Areceptor.
FILED	Thursday, August 06, 2020
APPL NO	16/947560
ART UNIT	1626 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/365 (20130101) Original (OR) Class A61K 31/366 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) Heterocyclic Compounds C07D 493/18 (20130101) C07D 493/22 (20130101)
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11351154 — Molecular genetic approach to treatment and diagnosis of alcohol and drug dependence

US 11351154	Johnson
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Alcohol Abuse and Alcoholism (NIAAA)
APPLICANT(S)	University of Virginia Patent Foundation (Charlottesville, Virginia)
ASSIGNEE(S)	University of Virginia Patent Foundation (Charlottesville, Virginia)
INVENTOR(S)	Bankole A. Johnson (Charlottesville, Virginia)
ABSTRACT	The present invention provides compositions and methods useful for diagnosing, treating, and monitoring alcohol dependence and disorders and susceptibility to alcohol dependence disorders, as well as drug related dependence and disorders.
FILED	Friday, July 17, 2020
APPL NO	16/931813
ART UNIT	1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/4178 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 2600/106 (20130101) C12Q 2600/156 (20130101)
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11351157 — Treatment of immunological disease using berberine nanoparticles

US 11351157	Li et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Complementary and Integrative Health (NCCIH)
APPLICANT(S)	Icahn School of Medicine at Mount Sinai (New York, New York); Sean N. Parker Foundation (San Francisco, California)
ASSIGNEE(S)	Icahn School of Medicine at Mount Sinai (New York, New York); Sean N. Parker Foundation (Palo Alto, California)
INVENTOR(S)	Xiu-Min Li (New York, New York); Changda Liu (New York, New York); Kamal Srivatava (New York, New York); Haiqiong Yu (New York, New York); Sean N Parker (San Francisco, California)
ABSTRACT	The disclosure provides methods of treating immunological conditions, e.g., allergy, by administration of berberine nanoparticles.
FILED	Monday, October 16, 2017
APPL NO	16/341582
ART UNIT	1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 9/5161 (20130101) A61K 31/727 (20130101) A61K 31/4375 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/08 (20180101)
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11351161 — Use of CDK9 inhibitors to reduce cartilage degradation

US 11351161	Haudenschild et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	The Regents Of The University Of California (Oakland, California)
INVENTOR(S)	Dominik Haudenschild (Davis, California); Paul Di Cesare (Sacramento, California); Jasper Yik (Elk Grove, California); Blaine Christiansen (Woodland, California)
ABSTRACT	The present invention relates to the use of cyclin-dependent kinase 9 (CDK9) inhibitors to reduce, inhibit and/or prevent cartilage degradation. CDK9 inhibitors can be used to reduce, inhibit and/or prevent cartilage degradation and loss of cartilage viability during allograft storage. CDK9 inhibitors can be used as a post-injury intervention treatment to reduce, inhibit and/or prevent the acute cellular responses that lead to future cartilage degradation and osteoarthritis.
FILED	Thursday, April 30, 2020
APPL NO	16/863892
ART UNIT	1615 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0226 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/453 (20130101) Original (OR) Class A61K 31/713 (20130101)
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11351167 — Treating cognitive decline and other neurodegenerative conditions by selectively removing senescent cells from neurological tissue

US 11351167	Laberge et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Aging (NIA)
APPLICANT(S)	Buck Institute for Research on Aging (Novato, California); Mayo Foundation for Medical Education and Research (Rochester, Minnesota); Unity Biotechnology, Inc. (Brisbane, California)
ASSIGNEE(S)	Buck Institute for Research on Aging (Novato, California); Mayo Foundation for Medical Education and Research (Rochester, Minnesota); Unity Biotechnology, Inc. (South San Francisco, California)
INVENTOR(S)	Remi-Martin Laberge (San Francisco, California); Judith Campisi (Berkeley, California); Marco Demaria (Groningen, Netherlands); Nathaniel David (Brisbane, California); James L. Kirkland (Rochester, Minnesota); Tamar Tchkonia (Rochester, Minnesota); Yi Zhu (Rochester, Minnesota); Darren J. Baker (Rochester, Minnesota); Jan M. A. van Deursen (Rochester, Minnesota)
ABSTRACT	Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.
FILED	Thursday, September 26, 2019
APPL NO	16/584638
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 9/0073 (20130101) A61K 31/404 (20130101) A61K 31/428 (20130101) A61K 31/495 (20130101) A61K 31/496 (20130101) Original (OR) Class A61K 31/728 (20130101) A61K 31/4178 (20130101) A61K 31/4375 (20130101) A61K 31/5377 (20130101) A61K 45/06 (20130101) A61K 47/36 (20130101) A61K 47/6807 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) A61P 11/00 (20180101) A61P 25/28 (20180101) A61P 27/02 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0081 (20130101) C12N 15/113 (20130101) C12N 2320/30 (20130101) C12N 2501/999 (20130101) C12N 2503/02 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/485 (20130101)
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11351185 — Use of isovalerylspiramycins as anti-cancer agents to inhibit metastasis

US 11351185	Jiang et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	ASCLEA CORPORATION (Las Vegas, Nevada); THE UNITED STATES OF AMERICA, as represented by the Secretary, Dept. of Health and Human Svcs. (Bethesda, Maryland)
ASSIGNEE(S)	ASCLEA CORPORATION (Las Vegas, Nevada); THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTES OF HEALTH (Bethesda, Maryland)
INVENTOR(S)	Enhong Jiang (Liaoning, China PRC); Zhengping Zhuang (Bethesda, Maryland); Jing Cui (Potomac, Maryland)
ABSTRACT	A pharmaceutical composition containing any one or more of 4″-O-isolvalerylspiramycin I, II and III counters tumorigenesis and reduces or prevents metastasis by inhibiting selenoprotein H to trigger genomic instability and cell-cycle arrest in cancer cells.
FILED	Wednesday, March 11, 2020
APPL NO	16/816068
ART UNIT	1623 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/7048 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101)
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11351200 — CDC-derived exosomes for treatment of ventricular tachyarrythmias

US 11351200	Marban et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	Cedars-Sinai Medical Center (Los Angeles, California)
ASSIGNEE(S)	Cedars-Sinai Medical Center (Los Angeles, California)
INVENTOR(S)	Eduardo Marban (Santa Monica, California); Eugenio Cingolani (Marina Del Rey, California); James Dawkins (Los Angeles, California)
ABSTRACT	Described herein are compositions and methods related to use of exosomes, including cardiosphere derived cell (CDC)-derived exosomes for treatment and prevention of heart related disease and conditions, such as ventral arrhythmias, such as tachycardias. CDC-derived exosomes delivered by endocardial injection can diminish the total amount of isolated late potentials associated with an isthmus of slow conduction, while reducing the isoelectric interval between late abnormal ventricular activity and decreasing the incidence of inducible ventricular arrhythmias, thereby providing a biological treatment for arrhythmias which otherwise requires therapeutic interventions with adverse effects.
FILED	Friday, June 02, 2017
APPL NO	16/305011
ART UNIT	1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 35/12 (20130101) A61K 35/34 (20130101) Original (OR) Class Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/3956 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/06 (20180101) A61P 9/10 (20180101)
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11351208 — Altering the intestinal microbiome in cystic fibrosis

US 11351208	O'Toole et al.
FUNDED BY	Environmental Protection Agency (EPA) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) National Institute of Allergy and Infectious Diseases (NIAID) National Institute of Environmental Health Sciences (NIEHS) National Institute of General Medical Sciences (NIGMS) NIH Office of the Director (NIHOD)
APPLICANT(S)	Trustees of Dartmouth College (Hanover, New Hampshire); Dartmouth-Hitchcock Clinic (Lebanon, New Hampshire)
ASSIGNEE(S)	Trastees of Dartmouth College (Hanover, New Hampshire); Dartmouth-Hitchcock Clime (Lebanon, New Hampshire)
INVENTOR(S)	George A. O'Toole (Hanover, New Hampshire); Juliette C. Madan (Lyme, New Hampshire)
ABSTRACT	The present disclosure relates to a method of altering intestinal microbiome in a patient having cystic fibrosis comprising administering at least one of Bifidobacterium and/or Bacteroides to a patient and allowing the Bifidobacterium and/or Bacteroides to alter the intestinal microbiome.
FILED	Tuesday, March 26, 2019
APPL NO	16/979824
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/741 (20130101) A61K 35/744 (20130101) A61K 35/745 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) A61P 11/00 (20180101)
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11351222 — Di-sulfide containing cell penetrating peptides and methods of making and using thereof

US 11351222	Pei et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Ohio State Innovation Foundation (Columbus, Ohio)
ASSIGNEE(S)	Ohio State Innovation Foundation (Columbus, Ohio)
INVENTOR(S)	Dehua Pei (Columbus, Ohio); Ziqing Qian (Columbus, Ohio)
ABSTRACT	Disclosed is a general, reversible bicyclization strategy to increase both the proteolytic stability and cell permeability of peptidyl drugs. A peptide drug is fused with a short cell-penetrating motif and converted into a conformationally constrained bicyclic structure through the formation of a pair of disulfide bonds. The resulting bicyclic peptide has greatly enhanced proteolytic stability as well as cell-permeability. Once inside the cell, the disulfide bonds are reduced to produce a linear, biologically active peptide. This strategy was applied to generate a cell-permeable bicyclic peptidyl inhibitor against the NEMO-IKK interaction.
FILED	Thursday, November 09, 2017
APPL NO	16/348706
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/12 (20130101) Original (OR) Class Peptides C07K 5/10 (20130101) C07K 7/06 (20130101) C07K 7/08 (20130101) C07K 7/50 (20130101) C07K 14/001 (20130101)
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11351225 — Methods for modulating development and function of photoreceptor cells

US 11351225	Haider
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI)
APPLICANT(S)	The Schepens Eye Research Institute, Inc. (Boston, Massachusetts)
ASSIGNEE(S)	The Schepens Eye Research Institute, Inc. (Boston, Massachusetts)
INVENTOR(S)	Neena B. Haider (Brookline, Massachusetts)
ABSTRACT	The present invention relates to compositions and methods comprising administering gene modifiers for treating ocular disease.
FILED	Monday, November 20, 2017
APPL NO	15/818470
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/13 (20130101) A61K 38/1783 (20130101) Original (OR) Class A61K 48/00 (20130101) A61K 48/005 (20130101) A61K 48/0083 (20130101) Peptides C07K 14/4705 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/10 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 999/99 (20130101)
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11351227 — Chemokine decoy receptors of rodent gammaherpesviruses and uses thereof

US 11351227	Fremont et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Washington University (St. Louis, Missouri)
ASSIGNEE(S)	Washington University (St. Louis, Missouri)
INVENTOR(S)	Daved Fremont (St. Louis, Missouri); Olga Lubman (St. Louis, Missouri); Andrew E. Gelman (St. Louis, Missouri); Yun Hsuan Lu (St. Louis, Missouri)
ABSTRACT	The present disclosure generally provides compositions and methods related to the field of immunology. Specifically, disclosed herein are chemokine binding proteins and methods of use thereof.
FILED	Friday, April 27, 2018
APPL NO	16/608672
ART UNIT	1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/1793 (20130101) Original (OR) Class
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11351238 — Vaccines against malaria transmission

US 11351238	Li
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Integrative Organismal Systems (IOS)
APPLICANT(S)	Jun Li (Miami, Florida)
ASSIGNEE(S)	THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (Miami, Florida)
INVENTOR(S)	Jun Li (Miami, Florida)
ABSTRACT	The invention pertains to methods and vaccines suitable for preventing or reducing malaria transmission. The vaccines block the interaction between α-tubulin from a malarial parasite and FREP-1 from the mid-gut of a malaria carrier mosquito, for example, Anopheles gambiae.
FILED	Friday, October 16, 2020
APPL NO	17/072394
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/015 (20130101) Original (OR) Class A61K 2039/545 (20130101) A61K 2039/575 (20130101)
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11351248 — Compositions, methods and kits for eliciting an immune response

US 11351248	Sampson et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	Duke University (Durham, North Carolina)
ASSIGNEE(S)	Duke University (Durham, North Carolina)
INVENTOR(S)	John H Sampson (Durham, North Carolina); Duane A Mitchell (Durham, North Carolina)
ABSTRACT	The present invention relates to compositions, methods, and kits for eliciting an immune response to at least one CMV antigen expressed by a cancer cell, in particular for treating and preventing cancer. CMV determination methods, compositions, and kits also are provided.
FILED	Wednesday, July 22, 2020
APPL NO	16/935813
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/7105 (20130101) A61K 39/12 (20130101) A61K 39/39 (20130101) A61K 39/245 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 2039/53 (20130101) A61K 2039/5154 (20130101) A61K 2039/5156 (20130101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2710/16122 (20130101) C12N 2710/16134 (20130101)
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11351250 — Pro-inflammatory and anti-cancer functions of toll-like receptor 4 antagonists

US 11351250	Kagan
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Children's Medical Center Corporation (Boston, Massachusetts)
ASSIGNEE(S)	Children's Medical Center Corporation (Boston, Massachusetts)
INVENTOR(S)	Jonathan C. Kagan (Brookline, Massachusetts)
ABSTRACT	The present invention provides methods and compositions for specific activation of inflammatory responses in dendritic cells (DCs). 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine (PAPC) and its oxidized variant (oxPAPC) were identified to promote DC-mediated immunity, and are provided as adjuvants in immunostimulatory compositions, including vaccines.
FILED	Friday, September 11, 2020
APPL NO	17/018045
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) Original (OR) Class A61K 2039/57 (20130101) A61K 2039/575 (20130101) A61K 2039/55511 (20130101) A61K 2039/55516 (20130101) A61K 2039/55561 (20130101) A61K 2039/55566 (20130101) A61K 2039/55572 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101)
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11351258 — Systems, methods, and biomaterials for radiation therapy

US 11351258	Ngwa
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The Brigham and Women's Hospital, Inc. (Boston, Massachusetts)
ASSIGNEE(S)	The Brigham and Women's Hospital, Inc (Boston, Massachusetts)
INVENTOR(S)	Wilfred F. Ngwa (Framingham, Massachusetts)
ABSTRACT	Methods and systems for radiation therapy involve administering a payload/combination of biocompatible high-Z and semiconductor NPs to tissue, such as a tumor or an eye. Ionizing radiation may be directed towards the payload, and ionized electrons generate Cerenkov radiation (CR). The CR interacts with semiconductor NPs to produce chemical species that are damaging to cells. The payload may be administered via injection or via a radiotherapy (RT) device that includes NPs in a biodegradable polymer matrix. Biodegradation of the polymer matrix, which results in release of its payload, may be remotely activated using, for example, electromagnetic or sound waves. The payload may include one or more immunologic adjuvants capable of promoting an immunologic response at remote sites (such as a metastatic tumors) that are separate from the site at which the NPs and adjuvants were administered.
FILED	Monday, April 03, 2017
APPL NO	16/090315
ART UNIT	1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 41/0038 (20130101) Original (OR) Class A61K 41/0057 (20130101) A61K 47/6929 (20170801) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/00 (20130101) A61N 5/1001 (20130101) A61N 2005/1098 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101)
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11351259 — HER3 inhibitor for modulating radiosensitivity

US 11351259	Wheeler et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Advancing Translational Sciences (NCATS)
APPLICANT(S)	DAIICHI SANKYO EUROPE GMBH (Munich, Germany)
ASSIGNEE(S)	DAIICHI SANKYO EUROPE GMBH (Munich, Germany)
INVENTOR(S)	Deric L. Wheeler (Madison, Wisconsin); Thore Hettmann (Martinsried, Germany)
ABSTRACT	The present invention relates to the use of an inhibitor of HER-3 for the treatment of a hyperproliferative disease in combination with radiation treatment.
FILED	Thursday, May 09, 2019
APPL NO	16/408040
ART UNIT	1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 41/0038 (20130101) Original (OR) Class A61K 51/1075 (20130101) A61K 51/1096 (20130101) A61K 2039/505 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/10 (20130101) A61N 2005/1098 (20130101) Peptides C07K 16/32 (20130101) C07K 2317/73 (20130101)
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11351263 — Polyplex delivery system for proteins, nucleic acids and protein/nucleic acid complexes

US 11351263	Gong et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
INVENTOR(S)	Shaoqin Gong (Middleton, Wisconsin); Yuyuan Wang (Madison, Wisconsin); Krishanu Saha (Middleton, Wisconsin); Amr Ashraf Abdeen (Madison, Wisconsin)
ABSTRACT	Provided herein are nanoplexes comprising a payload selected from a protein and/or a polynucleic acid; and a plurality of copolymers comprising a first copolymer that is poly(N,N′-bis(acryloyl)cystamine-poly(aminoalkyl)) (PBAP), a second copolymer that is poly(C_2-3akylene glycol)-PBAP-poly(C_2-3akylene glycol), and a third copolymer that is TG-poly(C_2-3akylene glycol)-PBAP-poly(C_2-3akylene glycol)-TG wherein TG at each occurrence is independently a targeting ligand, a cell penetrating peptide, an imaging agent or a capping group, provided that a plurality of TG groups is a targeting ligand; wherein the payload is non-covalently complexed to one or more of the copolymers, one or more of the first, second, and/or third copolymers comprises an endosomal escape group having a pKa of about 4.5 to about 6.5, and optionally one or more of the first, second, and/or third copolymers comprises a host and a guest non-covalent crosslinker.
FILED	Thursday, February 21, 2019
APPL NO	16/282174
ART UNIT	1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/7105 (20130101) A61K 38/465 (20130101) A61K 47/61 (20170801) A61K 47/595 (20170801) Original (OR) Class A61K 49/0054 (20130101) A61K 51/065 (20130101)
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11351264 — PAR2 mimetic peptides and uses thereof

US 11351264	Boitano et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona); BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
ASSIGNEE(S)	ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona); BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
INVENTOR(S)	Scott A. Boitano (Tucson, Arizona); Josef Vagner (Tucson, Arizona); Theodore J. Price (Austin, Texas)
ABSTRACT	This invention is in the field of medicinal pharmacology. In particular, the invention relates to protease activated receptor type 2 (PAR2) modulating compounds (e.g., mimetic peptides), compositions comprising such modulating compounds, and their use as therapeutics for the treatment of conditions involving PAR2 activity.
FILED	Friday, March 31, 2017
APPL NO	16/090525
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/177 (20130101) A61K 47/60 (20170801) Original (OR) Class A61K 47/61 (20170801) A61K 47/62 (20170801) A61K 47/542 (20170801) A61K 47/543 (20170801) A61K 47/545 (20170801) Peptides C07K 1/22 (20130101) C07K 5/10 (20130101) C07K 5/081 (20130101) C07K 5/101 (20130101) C07K 5/0808 (20130101) C07K 5/1013 (20130101) C07K 5/1024 (20130101) C07K 5/06034 (20130101) C07K 14/705 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/6427 (20130101) C12N 9/6445 (20130101)
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11351270 — Junctophilin-2 fragments and uses therefor

US 11351270	Song et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	University of Iowa Research Foundation (Iowa City, Iowa)
ASSIGNEE(S)	University of Iowa Research Foundation (Iowa City, Iowa)
INVENTOR(S)	Long-Sheng Song (Coralville, Iowa); Ang Guo (Iowa City, Iowa)
ABSTRACT	Truncated junctophilin-2 related proteins, transcriptional repressor domains, vectors encoding the proteins or domains, and methods of using the proteins and domains, are provided.
FILED	Wednesday, June 07, 2017
APPL NO	16/307807
ART UNIT	1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0278 (20130101) A01K 2217/206 (20130101) A01K 2227/105 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 38/17 (20130101) A61K 38/1719 (20130101) A61K 48/00 (20130101) A61K 48/0058 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/00 (20180101) Peptides C07K 14/4716 (20130101) C07K 2319/21 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101)
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11351273 — Method for delivering RNA to neurons to treat herpes infections

US 11351273	Bloom et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	University of Florida Research Foundation, Incorporated (Gainesville, Florida); Board of Supervisors Of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana)
ASSIGNEE(S)	Board Of Supervisors Of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana); University of Florida Research Foundation, Incorporated (Gainesville, Florida)
INVENTOR(S)	David C. Bloom (Gainesville, Florida); Alfred S. Lewin (Gainesville, Florida); Donna M. Neumann (New Orleans, Louisiana); Zachary L. Watson (Aurora, Colorado); Sonal Sanjeev Tuli (Gainesville, Florida); Gregory Scott Schultz (Gainesville, Florida)
ABSTRACT	Aspects of the application relate to methods and compositions for delivering therapeutic nucleic acids to neural cells or tissue in a subject. Additional aspects of the application relate to therapeutic nucleic acids, for example therapeutic ribozymes, that are useful for inhibiting viral reactivation in a subject.
FILED	Wednesday, June 21, 2017
APPL NO	16/312277
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 48/0091 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/22 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/062 (20130101) C12N 15/86 (20130101) C12N 15/1133 (20130101) C12N 2310/20 (20170501) C12N 2310/121 (20130101) C12N 2320/32 (20130101) C12N 2510/00 (20130101) C12N 2750/14122 (20130101) C12N 2750/14143 (20130101) C12N 2750/14145 (20130101)
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11351368 — Megahertz compression of nanosecond pulse bursts

US 11351368	Pakhomov et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	Old Dominion University Research Foundation (Norfolk, Virginia)
ASSIGNEE(S)	Old Dominion University Research Foundation (Norfolk, Virginia)
INVENTOR(S)	Andrei G. Pakhomov (Norfolk, Virginia); Shu Xiao (Norfolk, Virginia); Olga N. Pakhomova (Norfolk, Virginia); Maura Casciola (Norfolk, Virginia)
ABSTRACT	Methods and apparatuses (systems, devices, etc.) for treating biological tissue to evoke one or more desirable biological and/or physiological effects using pulsed electric fields in the sub-microsecond range at very low electric field strength (e.g., less than 1 kV/cm) but at high (e.g., megahertz) frequencies.
FILED	Wednesday, October 30, 2019
APPL NO	16/669419
ART UNIT	3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/08 (20130101) A61N 1/0412 (20130101) A61N 1/36002 (20170801) Original (OR) Class A61N 1/36034 (20170801)
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11351378 — Method to design temporal patterns of nervous system stimulation

US 11351378	Grill et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	DUKE UNIVERSITY (Durham, North Carolina)
ASSIGNEE(S)	DUKE UNIVERSITY (Durham, North Carolina)
INVENTOR(S)	Warren M. Grill (Chapel Hill, North Carolina); David T. Brocker (Cary, North Carolina); Alexander R. Kent (Durham, North Carolina)
ABSTRACT	The present invention relates to methods that enable one to design temporal patterns for the optimal stimulation of a nervous system, one or more nerve cells, or nervous tissue. In one embodiment, the present invention relates to methods to design improved stimulation patterns and/or genetic algorithms for the optimal stimulation of a nervous system, one or more nerve cells, or nervous tissue. In one embodiment, the present invention utilizes a model-based design to achieve a more optimal stimulation pattern for use in connection with a nervous system, one or more nerve cells, or nervous tissue (e.g., a human nervous system). In another embodiment, the model-based design of the present invention utilizes a systematic search method to identify parameters (e.g., design variables) that minimize a cost function (e.g., optimize the fitness of a particular design). In one instance, the system and method of the present invention is demonstrated via optimal temporal patterns of electrical stimulation for a nervous system, one or more nerve cells, or nervous tissue.
FILED	Thursday, December 21, 2017
APPL NO	16/472466
ART UNIT	3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/3606 (20130101) A61N 1/36067 (20130101) A61N 1/36075 (20130101) A61N 1/36132 (20130101) A61N 1/36139 (20130101) Original (OR) Class A61N 1/36171 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/20 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/30 (20180101) G16H 50/50 (20180101)
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11351379 — Systems and methods for controlling synchrony in a plurality of brain regions

US 11351379	Widge et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Mental Health (NIMH)
APPLICANT(S)	The General Hospital Corporation (Boston, Massachusetts)
ASSIGNEE(S)	The General Hospital Corporation (Boston, Massachusetts)
INVENTOR(S)	Alik S. Widge (Somerville, Massachusetts); Meng-Chen Lo (Cambridge, Massachusetts); Ethan Blackwood (Somerville, Massachusetts)
ABSTRACT	A method for controlling synchrony in a plurality of brain regions of a subject includes receiving signals from a source region of the subject's brain, determining at least one phase of the signals from the source region in a predetermined frequency band and delivering at least one stimulation pulse to at least one target region of the subjects brain based on the at least one phase of the signals from the source region to synchronize oscillations of the source region and the at least one target region.
FILED	Tuesday, November 13, 2018
APPL NO	16/762563
ART UNIT	3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0534 (20130101) A61N 1/36067 (20130101) A61N 1/36082 (20130101) A61N 1/36139 (20130101) Original (OR) Class A61N 1/36178 (20130101) A61N 1/37211 (20130101)
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11351399 — Combined local delivery of therapeutic agents using interventional devices and radiation

US 11351399	Desimone et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The University of North Carolina At Chapel Hill (Chapel Hill, North Carolina)
ASSIGNEE(S)	The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina)
INVENTOR(S)	Joseph Desimone (Chapel Hill, North Carolina); Joel Tepper (Chapel Hill, North Carolina); James Byrne (Chapel Hill, North Carolina)
ABSTRACT	A method and system for combination therapy utilizing local drug delivery and radiotherapy at a target site of body tissue are provided. The delivery system comprises a source electrode adapted to be positioned proximate to a target site of internal body tissue. A counter electrode is in electrical communication with the source electrode, and is configured to cooperate with the source electrode to form a localized electric field proximate to the target site. A cargo may be delivered to the target site when exposed to the localized electric field. Radiotherapy is applied to the target site in combination with the local drug delivery.
FILED	Tuesday, December 10, 2019
APPL NO	16/709377
ART UNIT	3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/007 (20130101) A61M 37/00 (20130101) A61M 2037/0007 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/327 (20130101) A61N 1/0509 (20130101) A61N 5/10 (20130101) A61N 5/1007 (20130101) A61N 5/1077 (20130101) Original (OR) Class A61N 2005/1098 (20130101)
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11351538 — Fluidic device and method of assembling same

US 11351538	Hosic et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	Northeastern University (Boston, Massachusetts)
ASSIGNEE(S)	NORTHEASTERN UNIVERSITY (Boston, Massachusetts)
INVENTOR(S)	Sanjin Hosic (Malden, Massachusetts); Ryan A. Koppes (Charlestown, Massachusetts); Shashi K. Murthy (Newton, Massachusetts); Abigail N. Koppes (Charlestown, Massachusetts); Jonathan R. Soucy (Boston, Massachusetts)
ABSTRACT	An embodiment is a scientific fluidic device and a method of assembly of single and multilayer fluidic devices via laser cut and assembly of double sided adhesives. The device includes a member defining a cavity and having two sides, both sides including an adhesive compound, and at least one substrate defining at least two plenums and coupling to the member, forming a flow path. The components of the fluidic device are produced via laser cut and assembly methods. The fluidic device remains intact via adhesive coupling between the substrate(s), member(s), and membrane(s). Altogether, the fluidic device requires assembly that is efficient and economical, resulting in high throughput manufacturing of the fluidic devices.
FILED	Friday, August 31, 2018
APPL NO	16/120198
ART UNIT	1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Chemical or Physical Laboratory Apparatus for General Use B01L 3/502707 (20130101) Original (OR) Class B01L 3/502715 (20130101) B01L 2200/12 (20130101) B01L 2200/027 (20130101) B01L 2200/028 (20130101) B01L 2200/0689 (20130101) B01L 2300/12 (20130101) B01L 2300/0627 (20130101) B01L 2300/0819 (20130101) B01L 2300/0861 (20130101) B01L 2300/0874 (20130101) B01L 2300/0887 (20130101)
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11351760 — Plasmonic patch as a universal fluorescence enhancer

US 11351760	Singamaneni et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S)	Washington University (St. Louis, Missouri)
ASSIGNEE(S)	Washington University (St. Louis, Missouri)
INVENTOR(S)	Srikanth Singamaneni (St. Louis, Missouri); Jingyi Luan (St. Louis, Missouri); Jeremiah Morrissey (St. Louis, Missouri); Evan Kharasch (St. Louis, Missouri)
ABSTRACT	Fluorescence-based techniques are the cornerstone of modern biomedical optics with applications ranging from bioimaging at various scales (organelle to organism) to detection and quantification of a wide variety of biological species of interest. However, feeble fluorescence signal remains a persistent challenge in meeting the ever-increasing demand to image, detect and quantify biological species of low abundance. Disclosed herein are simple and universal methods based on a flexible and conformal elastomeric film adsorbed with plasmonic nanostructures, referred to as “plasmonic skin” or “plasmonic patch”, that provide large and uniform enhancement of fluorescence on a variety of surfaces, through an “add-on-top” process. The novel fluorescence enhancement approach presented here represents a disease-, biomarker-, and application-agnostic ubiquitously-applicable fundamental and enabling technology to improve the sensitivity of existing analytical methodologies in an easy-to-handle and cost-effective manner, without changing and/or minimally altering the original procedures of the existing techniques.
FILED	Tuesday, November 27, 2018
APPL NO	16/765441
ART UNIT	1785 — Miscellaneous Articles, Stock Material
CURRENT CPC	Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 27/06 (20130101) Original (OR) Class B32B 2307/422 (20130101)
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11352328 — Heterocyclic compounds for the treatment of arenavirus

US 11352328	Plewe et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	ARISAN THERAPEUTICS INC. (San Diego, California)
ASSIGNEE(S)	Arisan Therapeutics Inc. (Carlsbad, California)
INVENTOR(S)	Michael Plewe (San Diego, California); Eric Brown (Santee, California); Vidyasagar Gantla (San Diego, California); Gregory Henkel (Carlsbad, California); Kenneth McCormack (Oceanside, California); Nadzeda V. Sokolova (San Diego, California); Young-Jun Shin (San Diego, California)
ABSTRACT	The invention relates to compounds of structural formula I wherein A, D, and E are independently N or C—R³, G, H, and J are independently N or C, K is N or C—H, L is N, N—R³or C—R³, and A, D, E, G, H, J, K, and L together cannot have more than 4 N, R¹is selected from (C₆to C₁₀) aryl, (C₂to C₉) heteroaryl, and 5-indolyl, wherein each of the said (C₆to C₁₀) aryl and (C₂to C₉) heteroaryl is substituted with at least one R^4agroup, and wherein said (C₂to C₉) heteroaryl is C-attached, and R²is selected from the group consisting of
FILED	Friday, July 07, 2017
APPL NO	16/309858
ART UNIT	1628 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/52 (20130101) A61K 31/52 (20130101) A61K 31/53 (20130101) A61K 31/53 (20130101) A61K 31/416 (20130101) A61K 31/416 (20130101) A61K 31/423 (20130101) A61K 31/423 (20130101) A61K 31/437 (20130101) A61K 31/437 (20130101) A61K 31/439 (20130101) A61K 31/454 (20130101) A61K 31/454 (20130101) A61K 31/519 (20130101) A61K 31/519 (20130101) A61K 31/713 (20130101) A61K 31/713 (20130101) A61K 31/4184 (20130101) A61K 31/4184 (20130101) A61K 31/4192 (20130101) A61K 31/4192 (20130101) A61K 31/4439 (20130101) A61K 31/4985 (20130101) A61K 31/4985 (20130101) A61K 31/5025 (20130101) A61K 31/5025 (20130101) A61K 31/5377 (20130101) A61K 31/5377 (20130101) A61K 31/7056 (20130101) A61K 31/7056 (20130101) A61K 31/7105 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Heterocyclic Compounds C07D 235/06 (20130101) Original (OR) Class C07D 235/20 (20130101) C07D 249/18 (20130101) C07D 413/00 (20130101) C07D 471/04 (20130101) C07D 471/08 (20130101) C07D 473/00 (20130101)
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11352333 — 5-benzylidene-4-oxazolidinones

US 11352333	Pierce et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	North Carolina State University (Raleigh, North Carolina)
ASSIGNEE(S)	North Carolina State University (Raleigh, North Carolina)
INVENTOR(S)	Joshua G. Pierce (Raleigh, North Carolina); Grant A. Edwards (Raleigh, North Carolina)
ABSTRACT	Provided herein are compounds that can exhibit activity as biofilm modulating agents (e.g., activity as biofilm inhibitors and/or activity as biofilm dispersal agents). The compounds can exhibit potent activity against Gram positive biofilms. The compounds can also exhibit activity against Gram negative biofilms. In some cases, the compounds can exhibit both biofilm modulation properties and antimicrobial activity. Compositions comprising these compounds, as well as methods of using thereof, are also described. For example, the compounds described herein can be used in human and animal health (e.g., for the treatment of infection), agriculture, marine coatings, and other coating applications related to prevention of biofilm (e.g., dental, medical, etc.).
FILED	Monday, November 02, 2020
APPL NO	17/087486
ART UNIT	1626 — Organic Chemistry
CURRENT CPC	Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 43/76 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/54 (20130101) A61L 29/16 (20130101) A61L 31/08 (20130101) A61L 31/16 (20130101) A61L 2300/204 (20130101) A61L 2300/404 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Heterocyclic Compounds C07D 263/40 (20130101) Original (OR) Class
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11352365 — Biased potent opioid-like agonists as improved medications to treat chronic and acute pain and methods of using the same

US 11352365	Rice et al.
FUNDED BY	Department of Health and Human Services (HHS)
APPLICANT(S)	THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (Bethesda, Maryland)
ASSIGNEE(S)	THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (Bethesda, Maryland)
INVENTOR(S)	Kenner Cralle Rice (Bethesda, Maryland); Arthur E. Jacobson (Rockville, Maryland); Fuying Li (Shanghai, China PRC); Eugene S. Gutman (Holland, Pennsylvania); Eric W. Bow (Washington, District of Columbia)
ABSTRACT	The present invention is directed to a compound having Formula (I) and its enantiomer: wherein the definitions of n, R, X, Y and Y³, and Z are provided in the disclosure. The invention is also directed to pharmaceutical compositions of the disclosed compounds, as well as their use as opioid-like agonists in the treatment of pain.
FILED	Monday, March 18, 2019
APPL NO	16/982196
ART UNIT	1625 — Organic Chemistry
CURRENT CPC	Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) Heterocyclic Compounds C07D 491/08 (20130101) Original (OR) Class
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11352373 — Apparatus and continuous flow process for production of boronic acid derivative

US 11352373	Pelz et al.
FUNDED BY	Department of Health and Human Services (HHS) Assistant Secretary for Preparedness and Response (ASPR) Biomedical Advanced Research and Development Authority (BARDA)
APPLICANT(S)	Melinta Subsidiary Corp. (Morristown, New Jersey)
ASSIGNEE(S)	MELINTA SUBSIDIARY CORP. (Morristown, New Jersey)
INVENTOR(S)	Andreas Pelz (Lincolnshire, Illinois); Christian Schuster (Lincolnshire, Illinois); Stefan Steinhofer (Lincolnshire, Illinois); Clemens Stueckler (Lincolnshire, Illinois); Maria Vasiloiu (Lincolnshire, Illinois); Christopher Zinganell (Lincolnshire, Illinois)
ABSTRACT	A process for a continuous production of a boronic acid derivative and an apparatus of performing the process are disclosed.
FILED	Wednesday, January 31, 2018
APPL NO	16/482195
ART UNIT	1626 — Organic Chemistry
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/02 (20130101) B01J 19/0013 (20130101) B01J 19/248 (20130101) B01J 2219/00033 (20130101) B01J 2219/00099 (20130101) B01J 2219/0286 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/027 (20130101) Original (OR) Class
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11352394 — Cyclic cell penetrating peptides comprising beta-hairpin motifs and methods of making and using thereof

US 11352394	Pei et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Ohio State Innovation Foundation (Columbus, Ohio)
ASSIGNEE(S)	Ohio State Innovation Foundation (Columbus, Ohio)
INVENTOR(S)	Dehua Pei (Columbus, Ohio); Ziqing Qian (Columbus, Ohio)
ABSTRACT	Disclosed herein are peptides having activity as cell penetrating peptides. In some embodiments, the peptides can comprise a cell penetrating peptide moiety and beta-hairpin turn creating moiety. In other embodiments, the peptides also comprise a cargo moiety.
FILED	Wednesday, November 22, 2017
APPL NO	16/462920
ART UNIT	1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 7/64 (20130101) Original (OR) Class C07K 14/001 (20130101) C07K 2319/10 (20130101)
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11352410 — Anti-KK-LC-1 T cell receptors

US 11352410	Stevanovic et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
ASSIGNEE(S)	The United States of American, as represented by the Secretary, Department of Health and Human Service (Bethesda, Maryland)
INVENTOR(S)	Sanja Stevanovic (Bethesda, Maryland); Christian S. Hinrichs (Bethesda, Maryland)
ABSTRACT	Disclosed is an isolated or purified T cell receptor (TCR) having antigenic specificity for Kita-Kyushu Lung Cancer Antigen 1_52-60(KK-LC-1_52-60). Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.
FILED	Monday, April 17, 2017
APPL NO	16/096118
ART UNIT	1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/7051 (20130101) Original (OR) Class C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/62 (20130101)
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11352421 — Treatment for adverse immune reaction to metal implant debris

US 11352421	Hallab et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S)	RUSH UNIVERSITY MEDICAL CENTER (Chicago, Illinois)
ASSIGNEE(S)	RUSH UNIVERSITY MEDICAL CENTER (Chicago, Illinois)
INVENTOR(S)	Nadim James Hallab (Oak Park, Illinois); Lauryn A. Samelko (Chicago, Illinois); Joshua J. Jacobs (Wilmette, Illinois)
ABSTRACT	Described herein is a method for treating or prophylaxis of adverse immune reaction to metal debris, metal induced delayed type hypersensitivity (DTH), or inflammatory osteolysis by attenuating the inflammatory response. In one aspect, the method involves inhibiting the nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP3) inflammasome/caspase-1 pathway or neutralizing or blocking the activity of interleukin 17 (IL-17), IL-17 receptor (IL-17R), IL-1R, IL-1β, IL-18, IL-21, IL-23 with anti-IL-17, anti-IL-17A, anti-IL-17F, anti-IL-17A/F, anti-IL-1, anti-IL-1β, anti-IL-18, anti-IL-21, anti-IL-23, anti-IL-1R, soluble IL-17 receptors, soluble IL-1 receptors, soluble IL-18 receptors, soluble IL-21 receptors, IL-17 receptor inhibitors, IL-1 receptor inhibitors, IL-18 receptor inhibitors, IL-21 receptor inhibitors, IL-23 receptor inhibitors, blocking agents, inflammasome inhibitors, or combinations thereof.
FILED	Tuesday, December 11, 2018
APPL NO	16/216159
ART UNIT	1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/00 (20130101) A61K 39/395 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/06 (20180101) Peptides C07K 16/244 (20130101) Original (OR) Class
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11352428 — Modulation of immune response using BTLA agonist antibodies

US 11352428	Ware et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Sanford Burnham Prebys Medical Discovery Institute (La Jolla, California)
ASSIGNEE(S)	Sanford Burnham Prebys Medical Discovery Institute (La Jolla, California)
INVENTOR(S)	Carl F. Ware (La Jolla, California); John Sedy (La Jolla, California); Paula Norris (La Jolla, California)
ABSTRACT	The present invention relates to the seminal discovery that BTLA agonist antibodies modulate the immune system. Specifically, the present invention provides antibodies which bind BTLA in the activated state enhancing BTLA signaling. The present invention further provides methods of treating immune and inflammatory diseases and disorders with a BTLA agonist antibody.
FILED	Friday, April 29, 2016
APPL NO	15/570013
ART UNIT	1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) A61P 37/00 (20180101) Peptides C07K 14/7151 (20130101) C07K 16/2818 (20130101) Original (OR) Class C07K 2317/34 (20130101) C07K 2317/75 (20130101) C07K 2319/30 (20130101)
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11352435 — Anti-CD133 monoclonal antibodies and related compositions and methods

US 11352435	Pfister et al.
FUNDED BY	Department of Health and Human Services (HHS)
APPLICANT(S)	THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (Rockville, Maryland)
ASSIGNEE(S)	The United States of America, as Represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
INVENTOR(S)	Thomas D. Pfister (Frederick, Maryland); Robert J. Kinders (Walkersville, Maryland); Tony Navas (Frederick, Maryland)
ABSTRACT	Anti-CD133 monoclonal antibodies having advantageous properties, products, compositions and kits comprising the monoclonal antibodies, methods (processes) of making the monoclonal antibodies and related compositions, as well as methods of using the monoclonal antibodies in analytical, diagnostic and therapeutic applications.
FILED	Friday, June 12, 2020
APPL NO	16/900596
ART UNIT	1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2896 (20130101) Original (OR) Class C07K 2317/33 (20130101) C07K 2317/73 (20130101)
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11352436 — Antibodies to TIP1 and methods of use thereof

US 11352436	Hallahan et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Dennis Hallahan (St. Louis, Missouri); Vaishali Kapoor (St. Louis, Missouri); Heping Yan (St. Louis, Missouri)
ASSIGNEE(S)	Washington University (St. Louis, Missouri)
INVENTOR(S)	Dennis Hallahan (St. Louis, Missouri); Vaishali Kapoor (St. Louis, Missouri); Heping Yan (St. Louis, Missouri)
ABSTRACT	The disclosure provides antigen binding proteins useful in the recognition of tumor cells and tumor specific delivery of drugs and therapies.
FILED	Friday, February 09, 2018
APPL NO	16/485100
ART UNIT	1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/30 (20130101) Original (OR) Class C07K 2317/73 (20130101) C07K 2317/76 (20130101) C07K 2317/77 (20130101) C07K 2317/622 (20130101)
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11352604 — Method of making cardiomyocytes from human pluripotent cells

US 11352604	Biermann et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
INVENTOR(S)	Mitch James Biermann (Madison, Wisconsin); Timothy Joseph Kamp (Madison, Wisconsin)
ABSTRACT	An improvement to the GiWi protocol for differentiating human pluripotent cells to developmentally mature cardiomyocytes includes a step of activating innate immunity in mesoderm stage cells in the in vitro differentiation culture. When the mesoderm cells, which are precursors to cardiac progenitor cells, are primed by exposure to an activator of innate immunity, a population of cardiomyocytes is generated that is more developmentally mature than is generated in the GiWi protocol without the primed step. Also provided herein are in vitro ventricular conductive microtissues and isolated, in vitro populations of ventricular conduction system-like cells and methods for making the same.
FILED	Friday, September 29, 2017
APPL NO	15/721076
ART UNIT	1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/34 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0606 (20130101) C12N 5/0657 (20130101) Original (OR) Class C12N 5/0696 (20130101) C12N 2501/33 (20130101) C12N 2501/50 (20130101) C12N 2501/056 (20130101) C12N 2501/415 (20130101) C12N 2501/727 (20130101) C12N 2506/02 (20130101) C12N 2506/45 (20130101)
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11352606 — Low oxygen tension enhances endothelial fate of human pluripotent stem cells

US 11352606	Gerecht et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Heart, Lung, and Blood Institute (NHLBI) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S)	THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland)
ASSIGNEE(S)	The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S)	Sharon Gerecht (Baltimore, Maryland); Sravanti Kusuma (Baltimore, Maryland)
ABSTRACT	Low oxygen tension is a critical regulator of the developing or regenerating vasculature. The present invention is based on the determination that low oxygen tension during early stages of early vascular cell (EVC) derivation induces endothelial commitment and maturation of pluripotent stem cells. Inhibition of reactive oxygen species generation during the early stages of differentiation abrogates the endothelial inductive effects of the low oxygen environments. Methods of generating various types of cells from pluripotent stem cells (PSCs) are described, as well as compositions and methods of use thereof. In particular, generation of EVCs, bicellular vascular populations, early endothelial cells (ECs) and pericytes via culture in a low oxygen environment is described.
FILED	Monday, March 17, 2014
APPL NO	15/115718
ART UNIT	1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/44 (20130101) A61K 35/545 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/069 (20130101) Original (OR) Class C12N 2500/02 (20130101) C12N 2501/15 (20130101) C12N 2501/165 (20130101) C12N 2506/02 (20130101) C12N 2506/45 (20130101) C12N 2533/54 (20130101)
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11352611 — Non-LTR-retroelement reverse transcriptase and uses thereof

US 11352611	Stamos et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
ASSIGNEE(S)	BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
INVENTOR(S)	Jennifer L. Stamos (Austin, Texas); Alfred M. Lentzsch (Austin, Texas); Seung Kuk Park (Austin, Texas); Georg Mohr (Austin, Texas); Alan M. Lambowitz (Austin, Texas)
ABSTRACT	A crystal structure of a Non-LTR-retroelement reverse transcriptase and methods of using the same to identify enzymes with improved activity are provided. Mutant reverse transcriptase enzymes and methods of using the same are also provided.
FILED	Wednesday, October 03, 2018
APPL NO	16/753201
ART UNIT	1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Peptides C07K 2299/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1276 (20130101) Original (OR) Class Enzymes C12Y 207/07049 (20130101) Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 29/58 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/00 (20190201)
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11352624 — Reducing nonsense-mediated MRNA decay

US 11352624	Krainer et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	Cold Spring Harbor Laboratory (Cold Spring Harbor, New York)
ASSIGNEE(S)	Cold Spring Harbor Laboratory (Cold Spring Harbor, New York)
INVENTOR(S)	Adrian Krainer (Huntington Station, New York); Isabel Aznarez (Cambridge, Massachusetts); Tomoki Nomakuchi (Syosset, New York)
ABSTRACT	The present disclosure relates to compositions and methods for inhibiting nonsense-mediated mRNA decay in a gene-specific manner, for example in the treatment of diseases or disorders caused by nonsense mutations.
FILED	Thursday, April 02, 2020
APPL NO	16/839034
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) A61K 31/726 (20130101) A61K 31/4245 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2320/30 (20130101) C12N 2320/31 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 2600/106 (20130101) C12Q 2600/156 (20130101)
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11352630 — SBE aptamers for treating IL-17a related diseases and conditions

US 11352630	Li et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	The Cleveland Clinic Foundation (Cleveland, Ohio)
ASSIGNEE(S)
INVENTOR(S)	Xiaoxia Li (Cleveland, Ohio); Tomasz Herjan (Beachwood, Ohio); Lingzi Hong (Cleveland Heights, Ohio); Donna Marie Driscoll (Cleveland, Ohio); Caini Liu (Solon, Ohio)
ABSTRACT	Provided herein are compositions, systems, kits, and methods for treating IL-17a related diseases and conditions using an SBE nucleic acid sequence that binds a SEFIR domain of an ACT1 protein.
FILED	Thursday, July 19, 2018
APPL NO	16/632757
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/06 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/115 (20130101) Original (OR) Class
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11352640 — Circular RNA for translation in eukaryotic cells

US 11352640	Anderson et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts)
INVENTOR(S)	Daniel G. Anderson (Framingham, Massachusetts); Robert Alexander Wesselhoeft (Boston, Massachusetts); Piotr S. Kowalski (Allston, Massachusetts)
ABSTRACT	Methods and constructs for engineering circular RNA are disclosed. In some embodiments, the methods and constructs comprise a vector for making circular RNA, the vector comprising the following elements operably connected to each other and arranged in the following sequence: a.) a 5′ homology arm, b.) a 3′ group I intron fragment containing a 3′ splice site dinucleotide, c.) optionally, a 5′ spacer sequence, d.) a protein coding or noncoding region, e.) optionally, a 3′ spacer sequence, f.) a 5′ Group I intron fragment containing a 5′ splice site dinucleotide, and g.) a 3′ homology arm, the vector allowing production of a circular RNA that is translatable or biologically active inside eukaryotic cells. Methods for purifying the circular RNA produced by the vector and the use of nucleoside modifications in circular RNA produced by the vector are also disclosed.
FILED	Tuesday, July 13, 2021
APPL NO	17/374497
ART UNIT	1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Peptides C07K 16/2803 (20130101) C07K 2317/31 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) C12N 15/85 (20130101) Original (OR) Class C12N 2015/859 (20130101) C12N 2015/8518 (20130101) C12N 2800/70 (20130101) C12N 2800/107 (20130101) C12N 2800/202 (20130101) C12N 2840/55 (20130101) C12N 2840/60 (20130101) C12N 2840/203 (20130101) C12N 2999/007 (20130101)
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11352641 — Circular RNA for translation in eukaryotic cells

US 11352641	Anderson et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts)
INVENTOR(S)	Daniel G. Anderson (Framingham, Massachusetts); Robert Alexander Wesselhoeft (Boston, Massachusetts); Piotr S. Kowalski (Allston, Massachusetts)
ABSTRACT	Methods and constructs for engineering circular RNA are disclosed. In some embodiments, the methods and constructs comprise a vector for making circular RNA, the vector comprising the following elements operably connected to each other and arranged in the following sequence: a.) a 5′ homology arm, b.) a 3′ group I intron fragment containing a 3′ splice site dinucleotide, c.) optionally, a 5′ spacer sequence, d.) a protein coding or noncoding region, e.) optionally, a 3′ spacer sequence, f) a 5′ Group I intron fragment containing a 5′ splice site dinucleotide, and g.) a 3′ homology arm, the vector allowing production of a circular RNA that is translatable or biologically active inside eukaryotic cells. Methods for purifying the circular RNA produced by the vector and the use of nucleoside modifications in circular RNA produced by the vector are also disclosed.
FILED	Tuesday, September 07, 2021
APPL NO	17/468100
ART UNIT	1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Peptides C07K 16/2803 (20130101) C07K 2317/31 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) C12N 15/85 (20130101) Original (OR) Class C12N 2015/859 (20130101) C12N 2015/8518 (20130101) C12N 2800/70 (20130101) C12N 2800/107 (20130101) C12N 2800/202 (20130101) C12N 2840/55 (20130101) C12N 2840/60 (20130101) C12N 2840/203 (20130101) C12N 2999/007 (20130101)
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11352642 — Methods and compositions for combination immunotherapy

US 11352642	Jones et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Dental and Craniofacial Research (NIDCR)
APPLICANT(S)	Etubics Corporation (Seattle, Washington)
ASSIGNEE(S)	Etubics Corporation (Seattle, Washington)
INVENTOR(S)	Frank R. Jones (Seattle, Washington); Elizabeth Gabitzsch (Seattle, Washington); Yvette Latchman (Seattle, Washington); Adrian Rice (Seattle, Washington)
ABSTRACT	Methods for generating immune responses using adenovirus vectors that allow multiple vaccinations with the same adenovirus vector and vaccinations in individuals with preexisting immunity to adenovirus are provided.
FILED	Thursday, January 07, 2016
APPL NO	15/542005
ART UNIT	1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) A61K 39/0011 (20130101) A61K 39/12 (20130101) A61K 39/12 (20130101) A61K 39/00117 (20180801) A61K 39/235 (20130101) A61K 39/001182 (20180801) A61K 39/39541 (20130101) A61K 39/39541 (20130101) A61K 39/39558 (20130101) A61K 45/06 (20130101) A61K 2039/53 (20130101) A61K 2039/54 (20130101) A61K 2039/70 (20130101) A61K 2039/505 (20130101) A61K 2039/545 (20130101) A61K 2039/575 (20130101) A61K 2039/585 (20130101) A61K 2039/5256 (20130101) A61K 2039/5258 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/20 (20180101) A61P 35/00 (20180101) A61P 35/04 (20180101) Peptides C07K 14/4705 (20130101) C07K 14/70596 (20130101) C07K 16/2818 (20130101) C07K 2317/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 2710/10023 (20130101) C12N 2710/10043 (20130101) C12N 2710/10071 (20130101) C12N 2710/10343 (20130101) C12N 2710/10371 (20130101) C12N 2710/20034 (20130101)
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11352647 — Crispr enzymes and systems

US 11352647	Zhang et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Mental Health (NIMH)
APPLICANT(S)	THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts)
ASSIGNEE(S)	THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts)
INVENTOR(S)	Feng Zhang (Cambridge, Massachusetts); David Arthur Scott (Cambridge, Massachusetts); Winston Xia Yan (Cambridge, Massachusetts); Sourav Choudhury (Cambridge, Massachusetts); Matthias Heidenreich (Cambridge, Massachusetts)
ABSTRACT	Embodiments disclosed herein are directed to engineered CRISPR-Cas effector proteins that comprise at least one modification compared to an unmodified CRISPR-Cas effector protein that enhances binding of the of the CRISPR complex to the binding site and/or alters editing preference as compared to wild type. In certain example embodiments, the CRISPR-Cas effector protein is a Type V effector protein. In certain other example embodiments, the Type V effector protein is Cpf1. Embodiments disclosed herein are directed to viral vectors for delivery of CRISPR-Cas effector proteins, including Cpf1. In certain example embodiments, the vectors are designed so as to allow packaging of the CRISPR-Cas effector protein within a single vector. There is also an increased interest in the design of compact promoters for packing and thus expressing larger transgenes for targeted delivery and tissue-specificity. Thus, in another aspect certain embodiments disclosed herein are directed to delivery vectors, constructs, and methods of delivering larger genes for systemic delivery.
FILED	Thursday, August 17, 2017
APPL NO	16/325898
ART UNIT	1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/1271 (20130101) A61K 9/5184 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) C12N 15/113 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2310/32 (20130101) C12N 2740/13042 (20130101) C12N 2740/13043 (20130101) C12N 2800/22 (20130101)
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11352661 — Single cell fluorescence in situ hybridization in microfluidic droplets

US 11352661	Sarkar et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Northeastern University (Boston, Massachusetts)
ASSIGNEE(S)	Northeastern University (Boston, Massachusetts)
INVENTOR(S)	Saheli Sarkar (Boston, Massachusetts); Tania Konry (Boston, Massachusetts)
ABSTRACT	The invention provides a device, method, and system for high throughput detection of nucleic acid expression in individual cells. Cells are encapsulated in aqueous microdroplets which are merged with a biocompatible matrix, allowing on-chip fluorescence in situ hybridization on both adherent and non-adherent cells. The invention also provides multiplexed detection of nucleic acids, proteins, and cellular activity. The device and methods can be used to assess cellular interactions and to test the effects of antitumor agents.
FILED	Wednesday, July 12, 2017
APPL NO	16/317308
ART UNIT	1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Chemical or Physical Laboratory Apparatus for General Use B01L 3/502784 (20130101) B01L 2200/0668 (20130101) B01L 2300/069 (20130101) B01L 2300/087 (20130101) B01L 2300/0816 (20130101) B01L 2300/0819 (20130101) B01L 2300/0867 (20130101) B01L 2300/0883 (20130101) B01L 2400/0487 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6841 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6458 (20130101)
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11352665 — Nucleic acid constructs and methods of use

US 11352665	Chee
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI)
APPLICANT(S)	Prognosys Biosciences, Inc. (San Diego, California)
ASSIGNEE(S)	Prognosys Biosciences, Inc. (San Diego, California)
INVENTOR(S)	Mark S. Chee (Encinitas, California)
ABSTRACT	The present invention provides oligonucleotide constructs, sets of such oligonucleotide constructs, and methods of using such oligonucleotide constructs to provide validated sequences or sets of validated sequences corresponding to desired ROIs. Such validated ROIs and constructs containing these have a wide variety of uses, including in synthetic biology, quantitative nucleic acid analysis, polymorphism and/or mutation screening, and the like.
FILED	Thursday, April 22, 2021
APPL NO	17/237948
ART UNIT	1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6809 (20130101) C12Q 1/6809 (20130101) C12Q 1/6809 (20130101) C12Q 1/6827 (20130101) C12Q 1/6827 (20130101) C12Q 1/6827 (20130101) C12Q 1/6834 (20130101) C12Q 1/6834 (20130101) C12Q 1/6834 (20130101) C12Q 1/6869 (20130101) Original (OR) Class C12Q 1/6874 (20130101) C12Q 1/6876 (20130101) C12Q 2525/131 (20130101) C12Q 2525/131 (20130101) C12Q 2525/131 (20130101) C12Q 2525/155 (20130101) C12Q 2525/155 (20130101) C12Q 2525/155 (20130101) C12Q 2537/143 (20130101) C12Q 2537/143 (20130101) C12Q 2537/143 (20130101) C12Q 2539/103 (20130101) C12Q 2539/103 (20130101) C12Q 2539/103 (20130101) C12Q 2563/149 (20130101) C12Q 2563/149 (20130101) C12Q 2563/149 (20130101) C12Q 2563/179 (20130101) C12Q 2563/179 (20130101) C12Q 2563/179 (20130101)
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11352669 — Single cell nucleic acid detection and analysis

US 11352669	Xie et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI)
APPLICANT(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S)	Xiaoliang Sunney Xie (Lexington, Massachusetts); Katsuyuki Shiroguchi (Arlington, Massachusetts); Peter A. Sims (Cambridge, Massachusetts); Tony Z. Jia (Cambridge, Massachusetts)
ABSTRACT	Methods and compositions for digital profiling of nucleic acid sequences present in a sample are provided.
FILED	Wednesday, June 30, 2021
APPL NO	17/363053
ART UNIT	1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6853 (20130101) C12Q 1/6853 (20130101) C12Q 1/6874 (20130101) Original (OR) Class C12Q 2525/131 (20130101) C12Q 2525/301 (20130101) C12Q 2537/16 (20130101) C12Q 2563/179 (20130101)
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11352670 — Methods of determining tissues and/or cell types giving rise to cell-free DNA, and methods of identifying a disease or disorder using same

US 11352670	Shendure et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI)
APPLICANT(S)	UNIVERSITY OF WASHINGTON (Seattle, Washington)
ASSIGNEE(S)	UNIVERSITY OF WASHINGTON (Seattle, Washington)
INVENTOR(S)	Jay Shendure (Seattle, Washington); Matthew Snyder (Seattle, Washington); Martin Kircher (Seattle, Washington)
ABSTRACT	The present disclosure provides methods of determining one or more tissues and/or cell-types contributing to cell-free DNA (“cfDNA”) in a biological sample of a subject. In some embodiments, the present disclosure provides a method of identifying a disease or disorder in a subject as a function of one or more determined more tissues and/or cell-types contributing to cfDNA in a biological sample from the subject.
FILED	Thursday, May 21, 2020
APPL NO	16/880884
ART UNIT	1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) C12Q 1/6881 (20130101) Original (OR) Class C12Q 1/6883 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) G16B 20/10 (20190201) G16B 20/20 (20190201) G16B 20/30 (20190201) G16B 30/00 (20190201) G16B 40/00 (20190201) G16B 40/10 (20190201) G16B 45/00 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101)
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11352675 — Devices and methods for antibiotic susceptability testing

US 11352675	Ciopyk et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Visby Medical, Inc. (San Jose, California)
ASSIGNEE(S)	VISBY MEDICAL, INC. (San Jose, California)
INVENTOR(S)	Brian Ciopyk (Santa Clara, California); Paul Dentinger (Sunol, California); Teresa Abraham (Washington, District of Columbia); Brandon Ma (Santa Clara, California); Kamal Kajouke (San Jose, California); Mackenzie Hunt (Santa Cruz, California); Austin Phung (San Jose, California)
ABSTRACT	The disclosure relates generally to molecular diagnostic devices configured to amplifying a single nucleotide polymorphism (SNP) locus and discriminate between two or more allelic variants of the SNP, indicating presence or absence of a target allele. In some embodiments, the molecular diagnostic devices are capable of detecting, at point-of-care, SNPs associated with resistance or susceptibility to antibiotic treatment of organism infections. In other aspects, the disclosure provides methods of treatment for disease or disorders (e.g. organism infections) where treatment is guided by presence or absence of an allele at a SNP locus as determined by such molecular diagnostic devices.
FILED	Thursday, December 31, 2020
APPL NO	17/139451
ART UNIT	1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/04 (20130101) C12Q 1/18 (20130101) C12Q 1/689 (20130101) Original (OR) Class
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11353400 — Methods for fluorescence imaging microscopy and Nano-FISH

US 11353400	Stamatoyannopoulos et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI)
APPLICANT(S)	Altius Institute for Biomedical Sciences (Seattle, Washington)
ASSIGNEE(S)	Altius Institute for Biomedical Sciences (Seattle, Washington)
INVENTOR(S)	John A. Stamatoyannopoulos (Seattle, Washington); Shreeram Akilesh (Seattle, Washington); Vivek Nandakumar (Seattle, Washington)
ABSTRACT	Disclosed herein are methods of detecting a target nucleic acid sequence, determining the localization of the target nucleic acid sequence, and/or quantifying the number of target nucleic acid sequences in a cell. This method may be used on small target nucleic acid sequences, and may be referred to as Nano-FISH.
FILED	Wednesday, July 19, 2017
APPL NO	16/319157
ART UNIT	1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0221 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0634 (20130101) C12N 5/0694 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6837 (20130101) C12Q 1/6841 (20130101) C12Q 1/6841 (20130101) C12Q 2521/301 (20130101) C12Q 2563/107 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 30/04 (20130101) C40B 40/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/30 (20130101) G01N 21/64 (20130101) Original (OR) Class G01N 21/78 (20130101) G01N 21/6458 (20130101) G01N 33/574 (20130101) G01N 33/582 (20130101) G01N 33/56966 (20130101) G01N 2015/0038 (20130101)
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11353448 — Methods and compositions for quantifying metabolites and proteins from single cells

US 11353448	Xue et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
ASSIGNEE(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
INVENTOR(S)	Min Xue (Pasadena, California); Wei Wei (Pasadena, California); James R. Heath (South Pasadena, California)
ABSTRACT	Methods and compositions for quantifying the cellular concentration of cyclic adenosine monophosphate (cAMP), cyclic guanine monophosphate (cGMP), glutathione, glucose, and glutamine in a single cell include the use of conjugates and analogs in immunofluorescent assays for on-chip quantification. These metabolite immunofluorescent assays may be incorporated with proteomic assays for simultaneous single cell analysis of metabolites and proteins.
FILED	Tuesday, February 16, 2016
APPL NO	15/045241
ART UNIT	1641 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/573 (20130101) G01N 33/5308 (20130101) Original (OR) Class
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11353454 — Methods for detection of flavivirus antibodies

US 11353454	Khurana
FUNDED BY	Department of Health and Human Services (HHS) Food and Drug Administration (FDA) Medical Countermeasures Initiative (MCMI)
APPLICANT(S)	The U.S.A., as represented by the Secretary, Department of Health and Human Services (Silver Spring, Maryland)
ASSIGNEE(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Silver Spring, Maryland)
INVENTOR(S)	Surender Khurana (Clarksburg, Maryland)
ABSTRACT	Isolated peptides that include one or more antigenic sites of Zika virus (ZIKV) and methods of their use and production are disclosed. The peptides can be used, for example, to detect exposure of a subject to a flavivirus infection, such as a ZIKV infection.
FILED	Thursday, March 26, 2020
APPL NO	16/831525
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2770/24121 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/566 (20130101) Original (OR) Class G01N 33/56983 (20130101)
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11353463 — Redox-based reagents for methionine bioconjugation

US 11353463	Lin et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	ShiXian Lin (Berkeley, California); XiaoYu Yang (Berkeley, California); F. Dean Toste (Berkeley, California); Christopher J. Chang (Berkeley, California)
ABSTRACT	Chemoselective conjugation is achieved through redox reactivity by reacting an N-transfer oxidant with a thioether substrate in a redox reaction in an aqueous environment to form a conjugation product. In embodiments, Redox-Activated Chemical Tagging (ReACT) strategies for methionine-based protein functionalization. Oxaziridine (Ox) compounds serve as oxidant-mediated reagents for direct functionalization by converting methionine to the corresponding sulfimide conjugation product.
FILED	Thursday, May 02, 2019
APPL NO	16/402113
ART UNIT	1641 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 47/643 (20170801) A61K 47/6889 (20170801) Heterocyclic Compounds C07D 273/01 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/025 (20130101) C12Q 1/26 (20130101) Enzymes C12Y 108/04013 (20130101) C12Y 108/04014 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/58 (20130101) G01N 33/6815 (20130101) Original (OR) Class G01N 2333/47 (20130101) G01N 2458/15 (20130101) Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 20/10 (20190201) G16C 20/70 (20190201)
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11353467 — Use of lipid particles in medical diagnostics

US 11353467	Louie et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Katherine B. Louie (Walnut Creek, California); Benjamin P. Bowen (Walnut Creek, California); Trent R. Northen (Walnut Creek, California)
ABSTRACT	Disclosed herein are methods for identifying one or more diseased cells in a subject. Some embodiments include providing a biological sample derived from a subject, analyzing the biological sample by mass spectrometry, and determining the abundance of one or more lipids in the biological sample, wherein an altered abundance of the one or more lipids in the biological sample, as compared to a reference level, indicates a presence of one or more diseased cells in the subject from which the biological sample is derived.
FILED	Thursday, January 23, 2014
APPL NO	14/761587
ART UNIT	1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/92 (20130101) Original (OR) Class G01N 33/574 (20130101) G01N 2405/04 (20130101) G01N 2405/08 (20130101) G01N 2458/15 (20130101) G01N 2560/00 (20130101) G01N 2800/7028 (20130101)
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11355218 — Patient-specific cellular pathway activity inference computer system

US 11355218	Vaske et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of General Medical Sciences (NIGMS) National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Biological Infrastructure (DBI)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	THF REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Charles J. Vaske (Santa Cruz, California); Stephen C. Benz (Santa Cruz, California); Joshua M. Stuart (Santa Cruz, California); David Haussler (Santa Cruz, California)
ABSTRACT	The present invention relates to methods for evaluating the probability that a patient's diagnosis may be treated with a particular clinical regimen or therapy.
FILED	Wednesday, August 02, 2017
APPL NO	15/667544
ART UNIT	3619 — Semiconductors/Memory
CURRENT CPC	Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) G16B 5/30 (20190201) Original (OR) Class G16B 25/00 (20190201) G16B 25/10 (20190201) G16B 40/00 (20190201) G16B 40/30 (20190201) Technologies for Adaptation to Climate Change Y02A 90/10 (20180101)
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11355238 — Method, system and computer program product for evaluation of blood glucose variability in diabetes from self-monitoring data

US 11355238	Kovatchev
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	Boris P. Kovatchev (Charlottesville, Virginia)
ASSIGNEE(S)	University of Virginia Patent Foundation (Charlottesville, Virginia)
INVENTOR(S)	Boris P. Kovatchev (Charlottesville, Virginia)
ABSTRACT	A system, computer program product, method and algorithm for evaluation of blood glucose variability—one of the most important parameters of diabetes management. An embodiment of the method may use routine self-monitoring blood glucose (SMBG) data collected over a period of 2-6 weeks, for example, based on a theory of risk analysis of blood glucose data. One aspect may include a method, system and computer program product for computing the Average Daily Risk Range (ADRR)—a measure of overall glucose variability. Another aspect may include a method, system, and computer program product for estimating separately the glucose variability in the hypoglycemic range via a Low BG Index (LBGI) and the glucose variability in the high BG range via High BG Index (HBGI) followed by a combination of the two indices into a single variability display.
FILED	Friday, January 05, 2007
APPL NO	12/159891
ART UNIT	1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) Original (OR) Class
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Department of Defense (DOD)

11350726 — Mortar transportation system

US 11350726	Davic et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Naval Surface Warfare Center (NSWC)
APPLICANT(S)	The United States of America, as represented by the Secretary of the Navy (Crane, Indiana)
ASSIGNEE(S)	The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Steven Davic (Crane, Indiana); Ethan L Spaid (Brooklyn Center, Minnesota); Charles R. Greer (Crane, Indiana); Christopher Brown (Bloomington, Indiana); Joseph Jachim (Bloomington, Indiana); Adriann Nicole Wilson (Crane, Indiana)
ABSTRACT	The present invention relates to a backpack system for transporting items and an accompanying device. In exemplary embodiments, carried items are kept secure within a plurality of item holders to prevent the items from moving. The item holders can be rigid structures like cylinders or flexible canvas pouches. In exemplary embodiments, the backpack system can have configurations for carrying either a device or additional items.
FILED	Thursday, July 25, 2019
APPL NO	16/521639
ART UNIT	3734 — Sheet Container Making, Package Making, Receptacles, Shoes, Apparel, and Tool Driving or Impacting
CURRENT CPC	Travelling or Camp Equipment: Sacks or Packs Carried on the Body A45F 3/06 (20130101) Original (OR) Class A45F 3/08 (20130101) A45F 3/10 (20130101) A45F 2003/003 (20130101) A45F 2200/0566 (20130101)
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11350845 — Phase-based passive source location in three-dimensions

US 11350845	Berdanier
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
ASSIGNEE(S)	United States of America as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
INVENTOR(S)	Charles A. Berdanier (Dayton, Ohio)
ABSTRACT	Passive location of an emitter is achieved by sensing a signal propagated from the emitter at multiple sensing locations and determining its phase at each sensing location. A three-dimensional region is searched to find an emitter location for which phase estimates of the signal at the emitter location are in good agreement among the sensing locations. An iterative search from a set of starting points in the region may be performed. The region may be subdivided and each region searched in parallel using multiple processors in parallel. Phase at the sensing locations may be determined locally, using synchronized clocks at the sensing locations, or at a common receiver. In the latter case, signal propagation time from the sensing location to the receiver location is taken into account. The emitter may be a wireless endoscopy capsule, for example.
FILED	Tuesday, February 19, 2019
APPL NO	16/279017
ART UNIT	3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 1/041 (20130101) A61B 5/061 (20130101) Original (OR) Class A61B 2562/0204 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 5/06 (20130101) G01S 5/22 (20130101) G01S 5/0226 (20130101)
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11350901 — Recurrence prognosis and prediction of added benefit of adjuvant chemotherapy in early stage non-small cell lung cancer with radiomic features on baseline computed tomography

US 11350901	Madabhushi et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Army Medical Research Acquisition Activity (USAMRAA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Center for Research Resources (NCRR) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	Case Western Reserve University (Cleveland, Ohio)
ASSIGNEE(S)	Case Western Reserve University (Cleveland, Ohio); The Cleveland Clinic Foundation (Cleveland, Ohio)
INVENTOR(S)	Anant Madabhushi (Shaker Heights, Ohio); Pranjal Vaidya (Cleveland, Ohio); Vamsidhar Velcheti (Pepper Pike, Ohio); Kaustav Bera (Cleveland, Ohio)
ABSTRACT	Embodiments generate an early stage NSCLC recurrence prognosis, and predict added benefit of adjuvant chemotherapy. Embodiments include processors configured to access a radiological image of a region of tissue demonstrating early stage NSCLC; segment a tumor represented in the radiological image; define a peritumoral region based on a morphological dilation of a boundary of the tumor; extract a radiomic signature that includes a set of tumoral radiomic features extracted from the tumoral region, and a set of peritumoral radiomic features extracted from the peritumoral region, based on a continuous time to event data; compute a radiomic score based on the radiomic signature; compute a probability of added benefit of adjuvant chemotherapy based on the radiomic score; and generate an NSCLC recurrence prognosis based on the radiomic score. Embodiments may display the radiomic score, or generate a personalized treatment plan based on the radiomic score.
FILED	Tuesday, November 27, 2018
APPL NO	16/200710
ART UNIT	3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 6/12 (20130101) A61B 6/032 (20130101) A61B 6/50 (20130101) A61B 6/463 (20130101) A61B 6/5217 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/0012 (20130101) G06T 7/12 (20170101) G06T 7/136 (20170101) G06T 7/187 (20170101) G06T 2207/10081 (20130101) G06T 2207/20076 (20130101) G06T 2207/20081 (20130101) G06T 2207/20152 (20130101) G06T 2207/30061 (20130101) G06T 2207/30096 (20130101) Image or Video Recognition or Understanding G06V 10/40 (20220101) G06V 10/446 (20220101) G06V 20/695 (20220101) G06V 20/698 (20220101) G06V 2201/031 (20220101)
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11351271 — RNA-based logic circuits with RNA binding proteins, aptamers and small molecules

US 11351271	Weiss et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts); Kyoto University (Kyoto, Japan)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts); Kyoto University (Kyoto, Japan)
INVENTOR(S)	Ron Weiss (Newton, Massachusetts); Liliana Wroblewska (Wilmington, Massachusetts); Velia Siciliano (Cambridge, Massachusetts); Tasuku Kitada (Ghent, Belgium); Maria Hottelet Foley (Cambridge, Massachusetts); Katie Bodner (Stanford, California); Hirohide Saito (Kyoto, Japan); Kei Endo (Chiba, Japan); Darrell J. Irvine (Arlington, Massachusetts); Tyler Wagner (Bel Air, Maryland); Jacob Becraft (Boston, Massachusetts)
ABSTRACT	Engineered synthetic RNA-based genetic circuits are provided that are regulated exclusively at the post-transcriptional level.
FILED	Tuesday, September 08, 2015
APPL NO	15/509258
ART UNIT	1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 48/0066 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/10 (20130101) C12N 15/63 (20130101) C12N 15/85 (20130101) C12N 2840/102 (20130101)
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11351275 — Metal complexes with bisphophonate or pyrophosphate useful as imaging agents

US 11351275	Lascola
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC)
APPLICANT(S)	Duke University (Durham, North Carolina)
ASSIGNEE(S)	Duke University (Durham, North Carolina)
INVENTOR(S)	Christopher David Lascola (Durham, North Carolina)
ABSTRACT	Provided herein are magnetic resonance imaging (MRI) contrast agents comprising a compound having a structure represented by: Y—X—Z, wherein, X is: Fe(III) or Mn(II), and Y and Z are each independently selected from pyrophosphate and bisphosphonate (e.g., 1-hydroxybisphosphonate), or a pharmaceutically acceptable hydrate and/or salt thereof. Methods of use of the MRI contrast agent are also provided.
FILED	Wednesday, April 03, 2019
APPL NO	16/373803
ART UNIT	1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/663 (20130101) A61K 31/675 (20130101) A61K 47/548 (20170801) A61K 49/06 (20130101) A61K 49/085 (20130101) A61K 49/101 (20130101) A61K 49/103 (20130101) Original (OR) Class A61K 49/106 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101)
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11351343 — Intravenous access assist device with safety feature

US 11351343	Shah et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Army Medical Research Acquisition Activity (USAMRAA) U.S. Army Medical Research and Materiel Command (USAMRMC)
APPLICANT(S)	Amit Shah (North Potomac, Maryland); Curt Kothera (Rockville, Maryland); Pablo Sztein (Silver Spring, Maryland)
ASSIGNEE(S)	INNOVITAL, LLC (Calverton, Maryland)
INVENTOR(S)	Amit Shah (North Potomac, Maryland); Curt Kothera (Rockville, Maryland); Pablo Sztein (Silver Spring, Maryland)
ABSTRACT	The present invention is a simple-to-use IV placement assist device with an added safety feature. A catheter advancer is slidably integrated with a base to guide advancement of a catheter linearly along the insertion path of the needle and catheter. A safety feature is engaged by a movable component moving from a first position to a second position, such movable enabling relative movement between the base and catheter advancer and/or catheter assembly, rotation of the needle about its length axis, and/or minor advancement of the catheter assembly to sheath the tip of the needle. The IV placement assist device stabilizes and guides the critical needle insertion and catheter advancement steps of a complication-prone and very common procedure.
FILED	Thursday, July 19, 2018
APPL NO	16/040104
ART UNIT	3783 — Body Treatment, Kinestherapy, and Exercising
CURRENT CPC	Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/3245 (20130101) A61M 5/3273 (20130101) A61M 25/0606 (20130101) Original (OR) Class A61M 25/0625 (20130101) A61M 25/0631 (20130101) A61M 25/0693 (20130101)
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11351368 — Megahertz compression of nanosecond pulse bursts

US 11351368	Pakhomov et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	Old Dominion University Research Foundation (Norfolk, Virginia)
ASSIGNEE(S)	Old Dominion University Research Foundation (Norfolk, Virginia)
INVENTOR(S)	Andrei G. Pakhomov (Norfolk, Virginia); Shu Xiao (Norfolk, Virginia); Olga N. Pakhomova (Norfolk, Virginia); Maura Casciola (Norfolk, Virginia)
ABSTRACT	Methods and apparatuses (systems, devices, etc.) for treating biological tissue to evoke one or more desirable biological and/or physiological effects using pulsed electric fields in the sub-microsecond range at very low electric field strength (e.g., less than 1 kV/cm) but at high (e.g., megahertz) frequencies.
FILED	Wednesday, October 30, 2019
APPL NO	16/669419
ART UNIT	3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/08 (20130101) A61N 1/0412 (20130101) A61N 1/36002 (20170801) Original (OR) Class A61N 1/36034 (20170801)
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11351530 — Light-assisted photocatalyst regeneration and oxygen-resilient radical polymerization

US 11351530	Johnson et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC)
APPLICANT(S)	MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts)
ASSIGNEE(S)	MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts)
INVENTOR(S)	Hadley Sikes Johnson (Arlington, Massachusetts); Hector Alan Aguirre Soto (Somerville, Massachusetts)
ABSTRACT	A photocatalyst can be regenerated with increasing efficiency, turnover number and turnover frequency in the presence of air by irradiating the photocatalyst with a first range of wavelengths of light that excite the photocatalyst to an intermediate and irradiating the intermediate with a second range of wavelengths of light that turns the intermediate to the photocatalyst.
FILED	Monday, November 06, 2017
APPL NO	15/804969
ART UNIT	1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/04 (20130101) B01J 31/0202 (20130101) B01J 35/004 (20130101) Original (OR) Class B01J 2231/70 (20130101) B01J 2231/125 (20130101) Acyclic or Carbocyclic Compounds C07C 409/00 (20130101) Heterocyclic Compounds C07D 311/80 (20130101) C07D 311/82 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 2/48 (20130101) C08F 4/32 (20130101) C08F 26/10 (20130101) C08F 2400/02 (20130101) C08F 2438/01 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/075 (20130101) C08J 2300/14 (20130101) Compositions of Macromolecular Compounds C08L 101/14 (20130101) C08L 2203/02 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/64 (20130101) G01N 2021/6417 (20130101)
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11351666 — Apparatus for limiting equipment burden when penetrating a mixed or composite material structure including metal utilizing a hammer-drill

US 11351666	Moan et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Naval Surface Warfare Center (NSWC)
APPLICANT(S)	The United States of America, as represented by the Secretary of the Navy (Crane, Indiana)
ASSIGNEE(S)	The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Brad Moan (Greenwood, Indiana); Eric Scheid (Bloomington, Indiana)
ABSTRACT	A drill bit in conjunction with a hammer-drill to penetrate composite metal and non-metal structure or structures including, for example, thick metal or rebar encountered during concrete, rock or masonry boring operations without requiring a change in drill equipment.
FILED	Wednesday, April 01, 2020
APPL NO	16/837311
ART UNIT	3672 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware
CURRENT CPC	Turning; Boring B23B 49/00 (20130101) B23B 51/00 (20130101) B23B 51/02 (20130101) B23B 51/04 (20130101) B23B 51/009 (20130101) B23B 51/00035 (20220101) B23B 51/0411 (20220101) B23B 2226/75 (20130101) B23B 2228/36 (20130101) B23B 2251/60 (20130101) Metal-working Not Otherwise Provided For; Combined Operations; Universal Machine Tools B23P 15/28 (20130101) Percussive Tools B25D 17/02 (20130101) Original (OR) Class B25D 17/08 (20130101) B25D 2217/0007 (20130101) Working Stone or Stone-like Materials B28D 1/146 (20130101) Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 10/00 (20130101) Technical Subjects Covered by Former US Classification Y10T 408/906 (20150115) Y10T 408/907 (20150115)
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11352107 — Facilitating search and rescue

US 11352107	Ripplinger et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Materiel Command (AFMC)
APPLICANT(S)	Battle Sight Technologies, LLC (Dayton, Ohio)
ASSIGNEE(S)	Battle Sight Technologies, LLC (Dayton, Ohio)
INVENTOR(S)	Nicholas R. Ripplinger (Springboro, Ohio); Christopher J. Vogt (Cincinnati, Ohio)
ABSTRACT	An apparatus that facilitates search and rescue, for example, in open water. The apparatus comprises a substrate with a particular geometry and a perimeter. The apparatus further comprises a cover positioned atop the substrate with the cover also having a particular geometry and perimeter, which correspond to the geometry and perimeter of the substrate. An air-tight seal seals the substrate perimeter to the cover perimeter and creates a sealed internal region. A breakable vessel holding an illuminable dye located in the sealed internal region, along with an activator that is also located in the sealed internal region. When the breakable vessel is broken, the illuminable dye reacts with the activator and illuminates the illuminable dye.
FILED	Friday, August 28, 2020
APPL NO	17/005530
ART UNIT	3617 — Miscellaneous Articles, Stock Material
CURRENT CPC	Launching, Hauling-out, or Dry-docking of Vessels; Life-saving in Water; Equipment for Dwelling or Working Under Water; Means for Salvaging or Searching for Underwater Objects B63C 9/20 (20130101) Original (OR) Class
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11352315 — Compositions and methods comprising a triaryl polyamine

US 11352315	Looper et al.
FUNDED BY	Department of Defense (DOD) Uniformed Services University of the Health Sciences (USUHS) Henry M Jackson Foundation for the Advancement of Military Medicine, Inc (HJF) Department of Veterans Affairs (DVA)
APPLICANT(S)	Curza Global, LLC (Provo, Utah); University of Utah Research Foundation (Salt Lake City, Utah)
ASSIGNEE(S)	Curza Global, LLC (Provo, Utah); University of Utah Research Foundation (Salt Lake City, Utah)
INVENTOR(S)	Ryan E. Looper (Salt Lake City, Utah); Dustin Williams (Bountiful, Utah); Paul R. Sebahar (Sandy, Utah); Travis J. Haussener (Salt Lake City, Utah); Hariprasada R. Kanna Reddy (Salt Lake City, Utah)
ABSTRACT	Compounds, compositions, and methods comprising a polyamine compound are described, which may be used to kill, disperse, treat, or reduce biofilms, or to inhibit or substantially prevent biofilm formation. In some aspects, the present invention relates to polyamine compounds that have antimicrobial or dispersing activity against a variety of bacterial strains capable of forming biofilms. In some aspects, the present invention relates to compositions and methods comprising the polyamine compound. In some aspects, the compounds, compositions, and methods enhance wound healing.
FILED	Friday, October 04, 2019
APPL NO	16/593143
ART UNIT	1626 — Organic Chemistry
CURRENT CPC	Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/02 (20180101) Acyclic or Carbocyclic Compounds C07C 211/27 (20130101) Original (OR) Class
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11352452 — Articles and methods related to labile crosslinking moieties

US 11352452	Hancock et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Chemical Biological Center (CCDC CBC) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Akita Innovations LLC (Billerica, Massachusetts)
ASSIGNEE(S)	Akita Innovations LLC (Billerica, Massachusetts)
INVENTOR(S)	Lawrence F. Hancock (North Andover, Massachusetts); Richard A. Minns (Arlington, Massachusetts)
ABSTRACT	Articles and methods related to the manufacture of polymers containing labile crosslinking moieties are generally described.
FILED	Wednesday, August 19, 2020
APPL NO	16/997837
ART UNIT	1765 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 8/50 (20130101) Original (OR) Class C08F 130/08 (20130101) C08F 228/02 (20130101) C08F 230/08 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 77/38 (20130101)
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11352640 — Circular RNA for translation in eukaryotic cells

US 11352640	Anderson et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts)
INVENTOR(S)	Daniel G. Anderson (Framingham, Massachusetts); Robert Alexander Wesselhoeft (Boston, Massachusetts); Piotr S. Kowalski (Allston, Massachusetts)
ABSTRACT	Methods and constructs for engineering circular RNA are disclosed. In some embodiments, the methods and constructs comprise a vector for making circular RNA, the vector comprising the following elements operably connected to each other and arranged in the following sequence: a.) a 5′ homology arm, b.) a 3′ group I intron fragment containing a 3′ splice site dinucleotide, c.) optionally, a 5′ spacer sequence, d.) a protein coding or noncoding region, e.) optionally, a 3′ spacer sequence, f.) a 5′ Group I intron fragment containing a 5′ splice site dinucleotide, and g.) a 3′ homology arm, the vector allowing production of a circular RNA that is translatable or biologically active inside eukaryotic cells. Methods for purifying the circular RNA produced by the vector and the use of nucleoside modifications in circular RNA produced by the vector are also disclosed.
FILED	Tuesday, July 13, 2021
APPL NO	17/374497
ART UNIT	1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Peptides C07K 16/2803 (20130101) C07K 2317/31 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) C12N 15/85 (20130101) Original (OR) Class C12N 2015/859 (20130101) C12N 2015/8518 (20130101) C12N 2800/70 (20130101) C12N 2800/107 (20130101) C12N 2800/202 (20130101) C12N 2840/55 (20130101) C12N 2840/60 (20130101) C12N 2840/203 (20130101) C12N 2999/007 (20130101)
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11352641 — Circular RNA for translation in eukaryotic cells

US 11352641	Anderson et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts)
INVENTOR(S)	Daniel G. Anderson (Framingham, Massachusetts); Robert Alexander Wesselhoeft (Boston, Massachusetts); Piotr S. Kowalski (Allston, Massachusetts)
ABSTRACT	Methods and constructs for engineering circular RNA are disclosed. In some embodiments, the methods and constructs comprise a vector for making circular RNA, the vector comprising the following elements operably connected to each other and arranged in the following sequence: a.) a 5′ homology arm, b.) a 3′ group I intron fragment containing a 3′ splice site dinucleotide, c.) optionally, a 5′ spacer sequence, d.) a protein coding or noncoding region, e.) optionally, a 3′ spacer sequence, f) a 5′ Group I intron fragment containing a 5′ splice site dinucleotide, and g.) a 3′ homology arm, the vector allowing production of a circular RNA that is translatable or biologically active inside eukaryotic cells. Methods for purifying the circular RNA produced by the vector and the use of nucleoside modifications in circular RNA produced by the vector are also disclosed.
FILED	Tuesday, September 07, 2021
APPL NO	17/468100
ART UNIT	1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Peptides C07K 16/2803 (20130101) C07K 2317/31 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) C12N 15/85 (20130101) Original (OR) Class C12N 2015/859 (20130101) C12N 2015/8518 (20130101) C12N 2800/70 (20130101) C12N 2800/107 (20130101) C12N 2800/202 (20130101) C12N 2840/55 (20130101) C12N 2840/60 (20130101) C12N 2840/203 (20130101) C12N 2999/007 (20130101)
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11352890 — Hybrid thermal barrier coating

US 11352890	Strock et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL)
APPLICANT(S)	United Technologies Corporation (Farmington, Connecticut)
ASSIGNEE(S)	Raytheon Technologies Corporation (Farmington, Connecticut)
INVENTOR(S)	Christopher W. Strock (Kennebunk, Maine); Kevin W. Schlichting (South Glastonbury, Connecticut)
ABSTRACT	An article has a metallic substrate having a plurality of recesses. A first coating is at least at the recesses and has: a splatted layer; and a columnar layer atop the splatted layer. A second coating is away from the recesses and has: a columnar layer atop the substrate without an intervening splatted layer.
FILED	Monday, June 12, 2017
APPL NO	15/620075
ART UNIT	1784 — Miscellaneous Articles, Stock Material
CURRENT CPC	Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 4/01 (20160101) C23C 4/02 (20130101) C23C 4/11 (20160101) C23C 4/18 (20130101) C23C 4/073 (20160101) C23C 4/123 (20160101) C23C 4/129 (20160101) C23C 4/134 (20160101) C23C 4/137 (20160101) C23C 14/024 (20130101) C23C 14/30 (20130101) C23C 14/042 (20130101) C23C 14/083 (20130101) C23C 28/042 (20130101) C23C 28/3215 (20130101) Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/288 (20130101) Original (OR) Class F01D 9/02 (20130101) F01D 11/08 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/30 (20130101) F05D 2230/90 (20130101) F05D 2230/312 (20130101) F05D 2230/313 (20130101) F05D 2250/182 (20130101) F05D 2250/294 (20130101) F05D 2300/17 (20130101) F05D 2300/2118 (20130101) F05D 2300/5023 (20130101) F05D 2300/50212 (20130101) Generating Combustion Products of High Pressure or High Velocity, e.g Gas-turbine Combustion Chambers F23R 3/002 (20130101) F23R 3/28 (20130101)
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11352981 — Multi-pulse rocket propulsion motor

US 11352981	Mahaffy
FUNDED BY	Department of Defense (DOD) United States Special Operations Command (SOCOM)
APPLICANT(S)	EXQUADRUM, INC. (Adelanto, California)
ASSIGNEE(S)	EXQUADRUM, INC. (Adelanto, California)
INVENTOR(S)	Kevin E. Mahaffy (Oak Hills, California)
ABSTRACT	A multi-pulse rocket propulsion motor for use with vehicles, such as space vehicles like satellites, rockets, and the like. The propulsion motor is a modular system that is capable of providing a plurality of discrete, controllable propulsion pulses. The propulsion motor can be used for primary propulsion of the vehicle and/or as a maneuvering thruster of the vehicle. The propulsion motor includes a plurality of propellant housings each containing a combustible propellant grain, a discharge plenum defining a plenum volume in communication with the discharge of each propellant housing, and a nozzle downstream from and in fluid communication with the plenum volume.
FILED	Friday, August 02, 2019
APPL NO	16/530315
ART UNIT	3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Cosmonautics; Vehicles or Equipment Therefor B64G 1/403 (20130101) Jet-propulsion Plants F02K 1/002 (20130101) F02K 9/08 (20130101) F02K 9/26 (20130101) F02K 9/28 (20130101) Original (OR) Class F02K 9/34 (20130101) F02K 9/36 (20130101) F02K 9/70 (20130101) F02K 9/80 (20130101) F02K 9/84 (20130101) F02K 9/97 (20130101) F02K 9/976 (20130101)
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11353046 — Microscale combustion for high density soft actuation

US 11353046	Heisser et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Department of the Navy (DON) Office of Naval Research (ONR)
APPLICANT(S)	Cornell University (Ithaca, New York)
ASSIGNEE(S)	Cornell University (Ithaca, New York)
INVENTOR(S)	Ronald Heisser (Ithaca, New York); Robert Shepherd (Ithaca, New York); Cameron Aubin (Ithaca, New York)
ABSTRACT	Disclosed herein are actuators and methods of making and actuating the same. Such actuators may comprise a body having a cavity, a membrane configured to cooperate with the cavity to form a combustion chamber, an inlet channel in fluid communication with the combustion chamber, an ignitor operable to ignite a combustible gas contained within the combustion chamber, and an outlet channel in fluid communication with the combustion chamber. The membrane may be configured to move in response to a change in pressure within the combustion chamber.
FILED	Wednesday, August 19, 2020
APPL NO	16/997929
ART UNIT	3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Systems Acting by Means of Fluids in General; Fluid-pressure Actuators, e.g Servomotors; Details of Fluid-pressure Systems, Not Otherwise Provided for F15B 15/10 (20130101) Original (OR) Class F15B 15/19 (20130101)
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11353269 — Thermal ground plane

US 11353269	Yang et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Navy (DON) Naval Information Warfare Center Pacific (NIWCPACIFIC)
APPLICANT(S)	Kelvin Thermal Technologies, Inc. (Boulder, Colorado)
ASSIGNEE(S)	Kelvin Thermal Technologies, Inc. (Boulder, Colorado)
INVENTOR(S)	Ronggui Yang (Broomfield, New York); Yung-Cheng Lee (Boulder, Colorado); Victor M. Bright (Boulder, Colorado); Chen Li (Columbia, South Carolina); Christopher Oshman (Boulder, Colorado); Bo Shi (Nanjing, China PRC); Jen-Hau Cheng (Boulder, Colorado); George P. Peterson (Atlanta, Georgia)
ABSTRACT	Methods, apparatuses, and systems are disclosed for flexible thermal ground planes. A flexible thermal ground plane may include a support member. The flexible thermal ground plane may include an evaporator region or multiple evaporator regions configured to couple with the support member. The flexible thermal ground plane may include a condenser region or multiple condenser regions configured to couple with the support member. The evaporator and condenser region may include a microwicking structure. The evaporator and condenser region may include a nanowicking structure coupled with the micro-wicking structure, where the nanowicking structure includes nanorods. The evaporator and condenser region may include a nanomesh coupled with the nanorods and/or the microwicking structure. Some embodiments may include a micromesh coupled with the nanorods and/or the microwicking structure.
FILED	Monday, November 11, 2019
APPL NO	16/680480
ART UNIT	3726 — Manufacturing Devices & Processes, Machine Tools & Hand Tools Group Art Units
CURRENT CPC	Metal-working Not Otherwise Provided For; Combined Operations; Universal Machine Tools B23P 15/26 (20130101) B23P 2700/09 (20130101) Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 15/04 (20130101) F28D 15/046 (20130101) F28D 15/0233 (20130101) F28D 15/0241 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/427 (20130101) H01L 23/473 (20130101) H01L 23/3677 (20130101) H01L 2924/00 (20130101) H01L 2924/0002 (20130101) H01L 2924/0002 (20130101) Technical Subjects Covered by Former US Classification Y10T 29/49353 (20150115)
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11353300 — Modular gas operated fin deployment system

US 11353300	Murphy
FUNDED BY	Department of Defense (DOD) Office of the Secretary of Defense (OSD) DOD Ordnance Technology Consortium (DOTC)
APPLICANT(S)	Raytheon Company (Waltham, Massachusetts)
ASSIGNEE(S)	Raytheon Company (Waltham, Massachusetts)
INVENTOR(S)	Timothy A. Murphy (Tucson, Arizona)
ABSTRACT	A projectile and deployment method ensures successful deployment of the projectile regardless of an external environment. Contacting engagement is maintained between a piston and deployable fins as the fins rotate from a folded position to a deployed position. The fins are pushed by the piston to rotate into a deployed position in which the fins are locked before the piston is able to eject from the assembly. Using the engaging tabs between the fins and the piston, and a modular pressure reservoir, the piston continues to push on the fins at least until the fins are deployed and locked. After locking, pressure in the projectile is equalized and the piston is launched off of the pressure reservoir. If the fins are not immediately deployed and locked, the piston will continue to push on the fins until the external environment enables full deployment or until the pressure is equalized.
FILED	Monday, April 06, 2020
APPL NO	16/840817
ART UNIT	3642 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 10/20 (20130101) Original (OR) Class
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11353301 — Kinetic energy vehicle with attitude control system having paired thrusters

US 11353301	Nguyen et al.
FUNDED BY	Department of Defense (DOD) Missile Defense Agency (MDA)
APPLICANT(S)	Raytheon Company (Waltham, Massachusetts)
ASSIGNEE(S)	Raytheon Company (Waltham, Massachusetts)
INVENTOR(S)	Huy P. Nguyen (Tucson, Arizona); Rob J. Fuentes (Tucson, Arizona); Michael Schmidt (Tucson, Arizona)
ABSTRACT	A kinetic energy vehicle (or warhead) has a divert thruster system and an attitude control system, both operatively coupled to receive pressurized gasses from a solid rocket motor that is operatively coupled to both systems. The attitude control system may have two pairs of attitude control thrusters, with one of the pairs diametrically opposed from the other pair, on opposite sides of an end (such as a rear end) of the vehicle. The attitude control thrusters all have radial and circumferential components to their thrust, and various combinations of the attitude control thrusters may be used to achieve desired roll, pitch, and/or yaw.
FILED	Wednesday, January 22, 2020
APPL NO	16/749324
ART UNIT	3642 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 10/663 (20130101) Original (OR) Class
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11353305 — Metal injection molded cased telescoped ammunition

US 11353305	Skowron et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Office of the Secretary of Defense (OSD) DOD Ordnance Technology Consortium (DOTC)
APPLICANT(S)	Concurrent Technologies Corporation (Johnstown, Pennsylvania)
ASSIGNEE(S)	Concurrent Technologies Corporation (Johnstown, Pennsylvania)
INVENTOR(S)	Todd Skowron (Johnstown, Pennsylvania); Juan Valencia (Johnstown, Pennsylvania); Shawn Rhodes (Somerset, Pennsylvania)
ABSTRACT	Disclosed is a cartridge case for various caliber ammunition that can consist essentially of a powdered metal and/or powdered metal alloy(s) that is formed into the cartridge case through an injection mold processing. Also disclosed is a method for forming a cartridge case, which may include use of Metal Injection Molding (“MIM”) processes to produce the cartridge case which retains a primer, propellant, and/or a bullet. Also disclosed are embodiments related to a case telescoped cartridge that may include a cap and a body. The body can consist essentially of or consists entirely of a powdered metal and/or powdered metal alloy(s) that has been formed through MIM. The cap can comprise plastic that has been formed through plastic molding or comprise powdered metal and/or powdered metal alloy(s) that has been formed through MIM.
FILED	Wednesday, April 08, 2020
APPL NO	16/842889
ART UNIT	3641 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Making Forged or Pressed Metal Products, e.g Horse-shoes, Rivets, Bolts or Wheels B21K 21/04 (20130101) B21K 21/14 (20130101) Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/102 (20220101) B22F 3/16 (20130101) B22F 3/225 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 45/00 (20130101) Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 5/28 (20130101) F42B 5/045 (20130101) F42B 5/285 (20130101) F42B 33/00 (20130101) Original (OR) Class
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11353392 — Contact-free holographic imaging of aerosol particles from mobile platforms

US 11353392	Berg et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL)
APPLICANT(S)	U.S. Army Combat Capabilities Development Command, Army Research Laboratory (Adelphi, Maryland)
ASSIGNEE(S)	The United States of America as represented by the Secretary of the Army (Washington, District of Columbia)
INVENTOR(S)	Matthew J. Berg (Manhattan, Kansas); Osku P. Kemppinen (Hyattsville, Maryland); Gorden W. Videen (Silver Spring, Maryland)
ABSTRACT	A device includes a filter that enhances a beam profile of a received pulsed laser; a first optical element to direct the pulsed laser as a reference wave towards an optical sensor; an open cavity positioned between the first optical element and the optical sensor. The open cavity receives an aerosol particle, which enters the open cavity from any direction. The reference wave illuminates the aerosol particle. An illuminated particle generates and directs an object wave towards the optical sensor. A pixel array is connected to the optical sensor. The pixel array receives the reference wave and the object wave. The optical sensor creates a contrast hologram comprising an interference pattern of the illuminated particle. A processor creates an image of the illuminated particle based on the contrast hologram.
FILED	Monday, September 21, 2020
APPL NO	17/027131
ART UNIT	2877 — Optics
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/0205 (20130101) G01N 15/1463 (20130101) Original (OR) Class G01N 2015/0065 (20130101) G01N 2015/0233 (20130101)
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11353479 — Laser-assisted device alteration using synchronized laser pulses

US 11353479	Vedagarbha et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL) Office of the Director of National Intelligence (ODNI) Intelligence Advanced Research Projects Activity (IARPA)
APPLICANT(S)	FEI EFA, Inc. (Fremont, California)
ASSIGNEE(S)	FEI EFA, Inc. (Fremont, California)
INVENTOR(S)	Praveen Vedagarbha (Fremont, California); Derryck Reid (Blackridge, United Kingdom); Keith Serrels (Fremont, California); James S. Vickers (San Jose, California)
ABSTRACT	A pulsed-laser LADA system is provided, which utilizes temporal resolution to enhance spatial resolution. The system is capable of resolving CMOS pairs within the illumination spot using synchronization of laser pulses with the DUT clock. The system can be implemented using laser wavelength having photon energy above the silicon bandgap so as to perform single-photon LADA or wavelength having photon energy below the silicon bandgap so as to generate two-photon LADA. The timing of the laser pulses can be adjusted using two feedback loops tied to the clock signal of an ATE, or by adjusting the ATE's clock signal with reference to a fixed-pulse laser source.
FILED	Tuesday, January 15, 2019
APPL NO	16/248423
ART UNIT	2896 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 1/07 (20130101) Original (OR) Class G01R 31/26 (20130101) G01R 31/30 (20130101) G01R 31/311 (20130101) G01R 31/31917 (20130101)
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11353627 — Compact star tracker with photonic crystal pointing

US 11353627	Lentz et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	US Gov't as represented by Secretary of Air Force (Wright-Patterson AFB, Ohio)
ASSIGNEE(S)	United States of America as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
INVENTOR(S)	Joshua Lentz (Niceville, Florida); Kevin Brink (Ft Walton Beach, Florida)
ABSTRACT	A star tracker includes imaging optics comprising a folding mirror, a lens, and a detector. The folding mirror bends light received from an optical axis through the lens that focuses the bent light onto the detector. The star tracker includes a steering mechanism that steers light from an adjustable field of view (FOV) to the optical axis of the imaging optics. The steering mechanism includes: (i) a first photonic crystal element comprising beam pointing spatially variant photonic crystals (SVPCs); (ii) a second photonic crystal element comprising beam pointing SVPCs that is positioned adjacent and axially aligned with the first photonic crystal element; and (iii) a housing that receives the first and second photonic crystal elements for independent rotation.
FILED	Friday, April 17, 2020
APPL NO	16/851906
ART UNIT	2874 — Optics
CURRENT CPC	Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 3/7867 (20130101) Optical Elements, Systems, or Apparatus G02B 1/005 (20130101) Original (OR) Class G02B 6/1225 (20130101) G02B 23/105 (20130101)
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11353659 — Photonic chip features for fiber attachment

US 11353659	Ciminelli et al.
FUNDED BY	Department of Defense (DOD)
APPLICANT(S)	Mario J. Ciminelli (Rochester, New York); Stefan Preble (Pittsford, New York); Jeffrey Steidle (Geneseo, New York); Paul Thomas (Pittsford, New York)
ASSIGNEE(S)	Rochester Institute of Technology (Rochester, New York)
INVENTOR(S)	Mario J. Ciminelli (Rochester, New York); Stefan Preble (Pittsford, New York); Jeffrey Steidle (Geneseo, New York); Paul Thomas (Pittsford, New York)
ABSTRACT	A photonic chip including a trench at the periphery of the photonic chip forming a recessed rim, wherein the recessed rim includes at least one geometric feature separating a plurality of waveguide locations, the at least one geometric feature suitable to prevent adhesive flow between the plurality of waveguide locations and method for preventing adhesive flow from interfering with bonding of optical fibers to the photonic chip is disclosed. A photonic chip including at least one optical fiber groove which includes an entrance portion and a non-entrance portion, wherein the entrance portion includes a flared opening having a greater clearance than the non-entrance portion and method for attaching an optical fiber to the photonic chip minimizing damage to at least one of the optical fiber and the photonic chip is disclosed.
FILED	Monday, March 30, 2020
APPL NO	16/834179
ART UNIT	2883 — Optics
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 6/26 (20130101) Original (OR) Class
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11353827 — Optical local oscillator for all-optical time scales, and associated timekeeping methods

US 11353827	Ye et al.
FUNDED BY	Department of Commerce (DOC) Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Physics (PHY)
APPLICANT(S)	The Regents of the University of Colorado, a body corporate (Denver, Colorado); Government of the United States of America as represented by the Secretary of Commerce (Gaithersburg, Maryland)
ASSIGNEE(S)	The Regents of the Univ. of Colorado, a body corp. (Denver, Colorado); Government of the United States of America, as represented by the Secretary of Commerse (Gaithersburg, Maryland)
INVENTOR(S)	Jun Ye (Louisville, Colorado); Eric G. Oelker (Boulder, Colorado); William R. Milner (Boulder, Colorado); John M. Robinson (Henderson, Nevada); Colin J. Kennedy (Boulder, Colorado); Tobias Bothwell (Boulder, Colorado); Dhruv Kedar (Boulder, Colorado); Terry Brown (Lafayette, Colorado)
ABSTRACT	The frequency stability of an optical local oscillator is improved by locking a laser to a silicon Fabry-Perot cavity operating at a temperature near 124 K, where the coefficient of thermal expansion of silicon is near zero. The cavity is mounted inside a cryostat housed in a temperature-stabilized vacuum system that is surrounded by an isolating enclosure and supported by an active vibration platform. Laser light is steered with a superpolished mirror toward a superpolished focusing optic that couples the laser light into the cavity. Light reflected from the cavity is used to stabilize the laser via the Pound-Drever-Hall technique, while light transmitted through the cavity is used to stabilize the laser power. A resonant transimpedance amplifier allows the laser power to be reduced, which reduces heating of the cavity caused by residual absorption of the light.
FILED	Friday, December 18, 2020
APPL NO	17/127616
ART UNIT	2849 — Optics
CURRENT CPC	Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/00 (20130101) G01J 3/45 (20130101) G01J 3/108 (20130101) Time-interval Measuring G04F 5/14 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/15 (20130101) Automatic Control, Starting, Synchronisation, or Stabilisation of Generators of Electronic Oscillations or Pulses H03L 7/26 (20130101) Transmission H04B 10/516 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

11353847 — Modifying additively manufactured part designs using topological analyses

US 11353847	Behandish et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	Palo Alto Research Center Incorporated (Palo Alto, California)
ASSIGNEE(S)	Palo Alto Research Center Incorporated (Palo Alto, California)
INVENTOR(S)	Morad Behandish (Mountain View, California); Saigopal Nelaturi (Mountain View, California)
ABSTRACT	Set differences between an as-designed and an as-manufactured model are computed. Discrepancies between the as-designed model and the as-manufactured model are determined based under-deposition and over-deposition features of the set differences. Based on the discrepancies, an input to a manufacturing instrument is changed to reduce topological differences between the as-manufactured model and the as-designed model.
FILED	Friday, December 28, 2018
APPL NO	16/235229
ART UNIT	2147 — Optics
CURRENT CPC	Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/4155 (20130101) Original (OR) Class G05B 2219/35193 (20130101)
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11354230 — Allocation of distributed data structures

US 11354230	Almasi et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
INVENTOR(S)	Gheorghe Almasi (Ardsley, New York); Barnaby Dalton (Mississauga, Canada); Ilie G. Tanase (Cedar Park, Texas); Ettore Tiotto (Whitby, Canada)
ABSTRACT	Allocating distributed data structures and managing allocation of a symmetric heap can include defining, using a processor, the symmetric heap. The symmetric heap includes a symmetric partition for each process of a partitioned global address space (PGAS) system. Each symmetric partition of the symmetric heap begins at a same starting virtual memory address and has a same global symmetric break. One process of a plurality of processes of the PGAS system is configured as an allocator process that controls allocation of blocks of memory for each symmetric partition of the symmetric heap. Using the processor executing the allocator process, isomorphic fragmentation among the symmetric partitions of the symmetric heap is maintained.
FILED	Tuesday, August 28, 2018
APPL NO	16/114222
ART UNIT	2135 — Memory Access and Control
CURRENT CPC	Electric Digital Data Processing G06F 12/023 (20130101) Original (OR) Class G06F 2212/656 (20130101) G06F 2212/657 (20130101) G06F 2212/1024 (20130101) G06F 2212/1056 (20130101)
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11354451 — Secure logic chip for resisting hardware trojan induced leakage in combinational logics

US 11354451	Shi et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	Government of the United States, as Represented by the Secretary of the Air Force (Rome, New York)
ASSIGNEE(S)	United States of America as represented by the Secretary of the Air Force (Rome, New York)
INVENTOR(S)	Yiyu Shi (Granger, Indiana); Travis Schulze (St. Louis, Missouri); Kevin Kwiat (Sarasota, Florida); Charles Kamhoua (Potomac, Maryland)
ABSTRACT	The invention is a secure logic chip with resistance to hardware Trojan induced data leakage. The invention solves the untrustworthy fabrication risk problem by introducing a secure logic chip design such that even when the design is entirely known to an attacker and a data leakage Trojan is injected subsequently, no useful information can be obtained. This invention contains several features including randomized encoding of binary logic, converting any combinational binary logic into one with randomized encoding, and partitioning a randomized encoded logic for split manufacturing.
FILED	Tuesday, October 30, 2018
APPL NO	16/174697
ART UNIT	2495 — Cryptography and Security
CURRENT CPC	Electric Digital Data Processing G06F 21/76 (20130101) Original (OR) Class G06F 21/755 (20170801)
VIEW PATENT	@ USPTO: Full Text PDF

11354452 — Secure logic chip for resisting hardware trojan induced leakage in combinational logic

US 11354452	Shi et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	Government of the United States, as Represented by the Secretary of the Air Force (Rome, New York)
ASSIGNEE(S)	United States of America as represented by the Secretary of the Air Force (Rome, New York)
INVENTOR(S)	Yiyu Shi (Granger, Switzerland); Travis Schulze (St. Louis, Missouri); Kevin Kwiat (Sarasota, Florida); Charles Kamhoua (Potomac, Maryland)
ABSTRACT	The invention is a secure logic chip with resistance to hardware Trojan induced data leakage. The invention solves the untrustworthy fabrication risk problem by introducing a secure logic chip design such that even when the design is entirely known to an attacker and a data leakage Trojan is injected subsequently, no useful information can be obtained. This invention contains several features including randomized encoding of binary logic, converting any combinational binary logic into one with randomized encoding, and partitioning a randomized encoded logic for split manufacturing.
FILED	Tuesday, October 30, 2018
APPL NO	16/174743
ART UNIT	2495 — Cryptography and Security
CURRENT CPC	Electric Digital Data Processing G06F 21/76 (20130101) Original (OR) Class G06F 21/755 (20170801)
VIEW PATENT	@ USPTO: Full Text PDF

11354812 — Techniques for accurate pose estimation

US 11354812	Menozzi et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	Applied Research Associates, Inc. (Albuquerque, New Mexico)
ASSIGNEE(S)	Applied Research Associates, Inc. (Albuquerque, New Mexico)
INVENTOR(S)	Alberico Menozzi (Raleigh, North Carolina); Chris F. Argenta (Cary, North Carolina); James B. Cook (Apex, North Carolina)
ABSTRACT	The described technology regards an augmented reality system and method for estimating a position of a location of interest relative to the position and orientation of a display, including receiving and selectively filtering a plurality of measurement vectors from a rate-gyroscope. Systems of the described technology include including a plurality of sensors, a processing module or other computation means, and a database. Methods of the described technology use data from the sensor package useful to accurately render graphical user interface information on a display.
FILED	Wednesday, April 10, 2019
APPL NO	16/380508
ART UNIT	2613 — Computer Graphic Processing, 3D Animation, Display Color Attribute, Object Processing, Hardware and Memory
CURRENT CPC	Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/165 (20130101) Optical Elements, Systems, or Apparatus G02B 27/017 (20130101) G02B 27/0093 (20130101) G02B 2027/0138 (20130101) G02B 2027/0141 (20130101) G02B 2027/0181 (20130101) Electric Digital Data Processing G06F 1/163 (20130101) G06F 3/01 (20130101) G06F 3/011 (20130101) G06F 3/04817 (20130101) G06F 11/00 (20130101) Image Data Processing or Generation, in General G06T 5/20 (20130101) G06T 7/33 (20170101) Original (OR) Class G06T 11/00 (20130101) G06T 19/006 (20130101) G06T 2200/24 (20130101)
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11355598 — Field managed group III-V field effect device with epitaxial back-side field plate

US 11355598	Srivastava et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	Analog Devices, Inc. (Norwood, Massachusetts)
ASSIGNEE(S)	Analog Devices, Inc. (Norwood, Massachusetts)
INVENTOR(S)	Puneet Srivastava (Wilmington, Massachusetts); James G. Fiorenza (Carlisle, Massachusetts); Daniel Piedra (Cambridge, Massachusetts)
ABSTRACT	A semiconductor device having a back-side field plate includes a buffer layer that includes a first compound semiconductor material, where the buffer layer is epitaxial to a crystalline substrate. The semiconductor device also includes field plate layer that is disposed on a surface of the buffer layer. The semiconductor device further includes a first channel layer disposed over the field plate layer, where the first channel layer includes the first compound semiconductor material. The semiconductor device further includes a region comprising a two-dimensional electron gas, where the two-dimensional electron gas is formed at an interface between the first channel layer and a second channel layer. The semiconductor device additionally includes a back-side field plate that is formed by a region of the field plate layer and is electrically isolated from other regions of the field plate layer.
FILED	Wednesday, July 03, 2019
APPL NO	16/502285
ART UNIT	2818 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/407 (20130101) Original (OR) Class H01L 29/2003 (20130101) H01L 29/7786 (20130101)
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11355774 — Thermally-drawn fiber including electrochemically active gels

US 11355774	Lee et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Jung Tae Lee (Cambridge, United Kingdom); Benjamin Jean-Baptiste Grena (San Francisco, California); Tural Khudiyev (Revere, Massachusetts); Chong Hou (Wuhan, China PRC); Yoel Fink (Brookline, Massachusetts)
ABSTRACT	Provided herein is a fiber having a fiber body including fiber body material with a longitudinal-axis fiber body length. A plurality of gel domains is disposed within the fiber body along at least a portion of the longitudinal-axis fiber body length. Each gel domain includes a porous host matrix material and a liquid gel component that is entrapped in the molecular structure of the host matrix material and that is disposed in interstices of the host material matrix. At least two of the gel domains within the fiber body are disposed directly adjacent to each other in direct physical contact with each other. This fiber can include polymeric fiber body material and gel domains including a porous polymer host matrix material and an ionically conducting liquid solvent that is entrapped in the molecular structure of the polymer host matrix material and disposed in interstices of the polymer host material matrix.
FILED	Thursday, March 21, 2019
APPL NO	16/361157
ART UNIT	1725 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/485 (20130101) H01M 4/5825 (20130101) H01M 10/02 (20130101) Original (OR) Class H01M 10/0565 (20130101) H01M 2004/023 (20130101) H01M 2004/025 (20130101) H01M 2300/0085 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

11355824 — Detection of an internal short circuit in a battery

US 11355824	Stefanopoulou et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA) U.S. Army Tank Automotive Research, Development and Engineering Center (TARDEC) Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S)	The Regents of The University of Michigan (Ann Arbor, Michigan)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
INVENTOR(S)	Anna G. Stefanopoulou (Ann Arbor, Michigan); Jason B. Siegel (Ann Arbor, Michigan); Sravan Pannala (Ann Arbor, Michigan); Gregory B. Less (Ypsilanti, Michigan); Ting Cai (Ann Arbor, Michigan); Mingxuan Zhang (Beijing, China PRC)
ABSTRACT	An electrical device comprises a battery cell; a pressure sensor for measuring swelling forces of the battery cell, optionally with voltage, temperature and current sensors, and a battery management system including a controller. The controller executes a program to: (i) determine a reference swelling force corresponding to a reference electrical signal received from the pressure sensor at an earlier reference time, (ii) determine a second swelling force corresponding to a second electrical signal received from the pressure sensor at a later second time, and (iii) determine whether a risk of internal short circuit of the battery cell exists by comparing a reference level of the reference electrical signal and a signal representative of the second electrical signal. When the signal representative of the second electrical signal exceeds the reference level of the reference electrical signal by a threshold amount, a risk of internal short circuit of the cell exists.
FILED	Monday, May 13, 2019
APPL NO	16/410714
ART UNIT	1722 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 58/12 (20190201) Measuring Electric Variables; Measuring Magnetic Variables G01R 31/52 (20200101) G01R 31/3648 (20130101) G01R 31/3842 (20190101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/486 (20130101) H01M 10/0525 (20130101) H01M 10/4257 (20130101) H01M 50/578 (20210101) Original (OR) Class H01M 2010/4271 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

11356027 — System and method for power conversion

US 11356027	Fogel et al.
FUNDED BY	Department of Defense (DOD)
APPLICANT(S)	Accion Systems, Inc. (Boston, Massachusetts)
ASSIGNEE(S)	Accion Systems, Inc. (Boston, Massachusetts)
INVENTOR(S)	Paul Fogel (Boston, Massachusetts); Mikhail Filippov (Boston, Massachusetts)
ABSTRACT	A polarity-selectable high voltage direct current power supply including a first drive assembly that transforms a first low voltage DC input into a first medium voltage alternating current output; a first HV output assembly that transforms the first LV AC output into a first HV DC output, wherein the first HV output assembly defines a first input stage; a polarity selector coupled between the second output junction of the first drive assembly and the first and second input stages of the first HV output assembly, the polarity selector operable between a first configuration and a second configuration; wherein in the first configuration the first HV DC output has a positive polarity; and wherein in the second configuration the first HV DC output has a negative polarity.
FILED	Thursday, October 08, 2020
APPL NO	17/066429
ART UNIT	2896 — Computer Error Control, Reliability, & Control Systems
CURRENT CPC	Electric Discharge Tubes or Discharge Lamps H01J 27/022 (20130101) Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/008 (20210501) H02M 1/08 (20130101) H02M 3/335 (20130101) H02M 3/3376 (20130101) H02M 3/33561 (20130101) H02M 3/33569 (20130101) Original (OR) Class H02M 7/103 (20130101)
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11356275 — Electronically verifying a process flow

US 11356275	Valdez et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Under Secretary of Defense for Acquisition and Sustainment (USDA&S) Trusted Silicon Stratus Distributed Transition Environment (TSS-DTE)
APPLICANT(S)	International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)	International Business Machines Corporation (Armonk, New York)
INVENTOR(S)	Enriquillo Valdez (Queens, New York); Richard H. Boivie (Monroe, Connecticut); Venkata Sitaramagiridharganesh Ganapavarapu (Peekskill, New York); Jinwook Jung (White Plains, New York); Gi-Joon Nam (Chappaqua, New York); Roman Vaculin (Larchmont, New York); James Thomas Rayfield (Ridgefield, Connecticut)
ABSTRACT	A method verifies an authenticity, integrity, and provenance of outputs from steps in a process flow. One or more processor(s) validate one or more inputs to each step in a process flow by verifying at least one of a hash and a digital signature of each of the one or more inputs. The processor(s) then generate digital signatures that cover outputs of each step and the one or more inputs to each step, such that the digital signatures result in a chain of digital signatures that are used to verify an authenticity, an integrity and a provenance of outputs of the one or more steps in the process flow.
FILED	Wednesday, May 27, 2020
APPL NO	16/884623
ART UNIT	2493 — Cryptography and Security
CURRENT CPC	Electric Digital Data Processing G06F 21/6218 (20130101) G06F 30/398 (20200101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6256 (20130101) Computer Systems Based on Specific Computational Models G06N 3/02 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0637 (20130101) H04L 9/3247 (20130101) Original (OR) Class H04L 2209/38 (20130101)
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11356378 — Combined write enable mask and credit return field

US 11356378	Brewer et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	Micron Technology, Inc. (Boise, Idaho)
ASSIGNEE(S)	Micron Technology, Inc. (Boise, Idaho)
INVENTOR(S)	Tony Brewer (Plano, Texas); David Patrick (McKinney, Texas)
ABSTRACT	A credit return field is used in a credit-based flow control system to indicate that one or more credits are being returned to a sending device from a receiving device. Based on the number of credits available, the sending device determines whether to send device or wait until more credits are returned. A write enable mask allows a wide data field to be used even when a smaller amount of data is to be written. A novel data packet uses a combined write enable mask and credit return field. In one mode, the field contains a write enable mask. In another mode, the field contains credit return data. If the field contains credit return data, a default value (e.g., all ones) is used for the write enable mask. The mode may be selected based on another value in the data packet.
FILED	Monday, August 31, 2020
APPL NO	17/007701
ART UNIT	2411 — Multiplex and VoIP
CURRENT CPC	Transmission of Digital Information, e.g Telegraphic Communication H04L 47/39 (20130101) Original (OR) Class H04L 49/9026 (20130101) H04L 61/6095 (20130101)
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11356599 — Human-automation collaborative tracker of fused object

US 11356599	Stanard et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	US Gov't as represented by Secretary of Air Force (Wright-Patterson AFB, Ohio)
ASSIGNEE(S)	United States of America as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
INVENTOR(S)	Terry W. Stanard (Dayton, Ohio); Theus H. Aspiras (Huber Heights, Ohio); Vijayan K. Asari (Dayton, Ohio); Taleri L. Hammack (Fairborn, Ohio)
ABSTRACT	A system includes a control station that enables efficient human collaboration with automated object tracking. The control station is communicatively coupled to an aerial vehicle to receive full motion video of a ground scene taken by an airborne sensor of the aerial vehicle. The control station spatially registers features of a movable object present in the ground scene and determines motion of the movable object relative to the ground scene. The control station predicts a trajectory of the movable objective relative to the ground scene. The control station tracks the movable object based on data fusion of: (i) the spatially registered features; (ii) the determined motion; and (iii) the predicted trajectory of the movable object. The control station presents a tracking annotation and a determined confidence indicator for the tracking annotation on a user interface device to facilitate human collaboration with object tracking.
FILED	Monday, February 08, 2021
APPL NO	17/169660
ART UNIT	2482 — Recording and Compression
CURRENT CPC	Image Data Processing or Generation, in General G06T 7/246 (20170101) G06T 2207/10016 (20130101) G06T 2207/30232 (20130101) G06T 2207/30241 (20130101) Pictorial Communication, e.g Television H04N 5/28 (20130101) H04N 5/23216 (20130101) Original (OR) Class H04N 5/23218 (20180801)
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11356925 — Systems and methods of mobile ad hoc network IP roaming

US 11356925	Stevens et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Contracting Command (ACC) Non-Profit Organization (NPO) National Spectrum Consortium (NSC)
APPLICANT(S)	Rockwell Collins, Inc. (Cedar Rapids, Iowa)
ASSIGNEE(S)	Rockwell Collins, Inc. (Cedar Rapids, Iowa)
INVENTOR(S)	James A. Stevens (Cedar Rapids, Iowa); Jeffrey D. Bouis (Cedar Rapids, Iowa); Naveen Rajanikantha (Cedar Rapids, Iowa)
ABSTRACT	A network device includes at least one of a baseband interface or a loopback interface, a wireless radio frequency (RF) interface, and a processing circuit. The baseband interface is coupled to a first node. The wireless RF interface is coupled to a second node. The processing circuit assigns a routable address to the at least one of the baseband interface or the loopback interface, assigns a non-routable address to the first node based on the first node being a gateway interface, assigns a routable address to the first node based on the first node not being a gateway interface, and assigns a non-routable address to the second node based on the second node being coupled to the wireless RF interface.
FILED	Thursday, December 19, 2019
APPL NO	16/721763
ART UNIT	2412 — Multiplex and VoIP
CURRENT CPC	Transmission H04B 1/0003 (20130101) Wireless Communication Networks H04W 40/248 (20130101) Original (OR) Class H04W 80/02 (20130101) H04W 84/18 (20130101) H04W 92/06 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

National Science Foundation (NSF)

11350921 — Pressure-regulating implant and methods of use thereof

US 11350921	Macknik et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Social, Behavioral and Economic Sciences (SBE) SBE Office of Multidisciplinary Activities (SMA)
APPLICANT(S)	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (Albany, New York)
ASSIGNEE(S)	The Research Foundation for the State University of New York (Albany, New York)
INVENTOR(S)	Stephen Macknik (Brooklyn, New York); Olivya Caballero (Brooklyn, New York); Manuel Ledo (Brooklyn, New York); Susana Martinez-Conde (Brooklyn, New York)
ABSTRACT	Provided is an implant, including a chamber having an interior radius wherein the interior radius has a flange, a cover slip, a cup, a setting member, a securing member, a resistance member, and an opposing member, wherein the cover slip, cup, resisting member, and setting member are attached to one another, the setting member sets on a flange and the securing member secures the setting member to the flange, the resistance member includes a flexibility and a longitudinal axis with a length wherein the flexibility permits modification of the length, and the opposing member sets a minimum length of the longitudinal axis. Also provided is a method of using said implant including affixing the chamber to a skull of a mammal.
FILED	Monday, April 01, 2019
APPL NO	16/615968
ART UNIT	3773 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies
CURRENT CPC	Diagnosis; Surgery; Identification A61B 17/0218 (20130101) Original (OR) Class
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11351238 — Vaccines against malaria transmission

US 11351238	Li
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Integrative Organismal Systems (IOS)
APPLICANT(S)	Jun Li (Miami, Florida)
ASSIGNEE(S)	THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (Miami, Florida)
INVENTOR(S)	Jun Li (Miami, Florida)
ABSTRACT	The invention pertains to methods and vaccines suitable for preventing or reducing malaria transmission. The vaccines block the interaction between α-tubulin from a malarial parasite and FREP-1 from the mid-gut of a malaria carrier mosquito, for example, Anopheles gambiae.
FILED	Friday, October 16, 2020
APPL NO	17/072394
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/015 (20130101) Original (OR) Class A61K 2039/545 (20130101) A61K 2039/575 (20130101)
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11351522 — Highly active metal oxide supported atomically dispersed platinum group metal catalysts

US 11351522	Lou et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	Yang Lou (Tempe, Arizona); Jingyue Liu (Scottsdale, Arizona)
ASSIGNEE(S)	Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona)
INVENTOR(S)	Yang Lou (Tempe, Arizona); Jingyue Liu (Scottsdale, Arizona)
ABSTRACT	A nanocatalyst including single atoms of platinum dispersed on a nanoscale metal oxide, and the nanocatalyst comprises 0.01 wt % to 1 wt % platinum. Preparing the nanocatalyst includes combining a solution comprising a nanoscale metal oxide and a compound containing a Group 10 metal to yield a mixture, aging the mixture for a length of time, filtering the mixture to yield a solid, washing the solid to eliminate water soluble anions, and calcining the solid to yield a nanocatalyst including single atoms or clusters of atoms of the Group 10 metal on the nanoscale metal oxide.
FILED	Wednesday, June 10, 2020
APPL NO	16/898173
ART UNIT	1772 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/04 (20130101) B01J 23/10 (20130101) B01J 23/42 (20130101) Original (OR) Class B01J 23/83 (20130101) B01J 23/745 (20130101) B01J 35/0013 (20130101) B01J 37/06 (20130101) B01J 37/088 (20130101) B01J 37/0221 (20130101)
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11351710 — Multilayered structures and uses thereof in security markings

US 11351710	Baer et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio)
ASSIGNEE(S)	CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio)
INVENTOR(S)	Eric Baer (Cleveland Heights, Ohio); Andy Olah (Spencer, Ohio); Zhenpeng Li (Shaker Heights, Ohio); Michael Hore (Shaker Heights, Ohio); Cong Zhang (Cleveland, Ohio)
ABSTRACT	A security marking has a physically unclonable function (PUF) wherein the PUF includes a disordered multilayer photonic crystal structure having an electromagnetic transmission and/or reflection spectrum and/or spectra upon receipt of electromagnetic radiation within a photonic bandgap region of the structure that is unique to the structure.
FILED	Monday, December 06, 2021
APPL NO	17/543272
ART UNIT	2886 — Optics
CURRENT CPC	Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 48/001 (20190201) Original (OR) Class B29C 48/08 (20190201) B29C 48/21 (20190201) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2105/0032 (20130101) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2007/008 (20130101) Books; Book Covers; Loose Leaves; Printed Matter Characterised by Identification or Security Features; Printed Matter of Special Format or Style Not Otherwise Provided For; Devices for Use Therewith and Not Otherwise Provided For; Movable-strip Writing or Reading Apparatus B42D 25/21 (20141001) B42D 25/45 (20141001) B42D 25/324 (20141001) B42D 25/328 (20141001) B42D 25/378 (20141001) B42D 25/382 (20141001) B42D 25/387 (20141001) Optical Elements, Systems, or Apparatus G02B 1/04 (20130101) G02B 5/1814 (20130101) G02B 2005/1804 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

11351760 — Plasmonic patch as a universal fluorescence enhancer

US 11351760	Singamaneni et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S)	Washington University (St. Louis, Missouri)
ASSIGNEE(S)	Washington University (St. Louis, Missouri)
INVENTOR(S)	Srikanth Singamaneni (St. Louis, Missouri); Jingyi Luan (St. Louis, Missouri); Jeremiah Morrissey (St. Louis, Missouri); Evan Kharasch (St. Louis, Missouri)
ABSTRACT	Fluorescence-based techniques are the cornerstone of modern biomedical optics with applications ranging from bioimaging at various scales (organelle to organism) to detection and quantification of a wide variety of biological species of interest. However, feeble fluorescence signal remains a persistent challenge in meeting the ever-increasing demand to image, detect and quantify biological species of low abundance. Disclosed herein are simple and universal methods based on a flexible and conformal elastomeric film adsorbed with plasmonic nanostructures, referred to as “plasmonic skin” or “plasmonic patch”, that provide large and uniform enhancement of fluorescence on a variety of surfaces, through an “add-on-top” process. The novel fluorescence enhancement approach presented here represents a disease-, biomarker-, and application-agnostic ubiquitously-applicable fundamental and enabling technology to improve the sensitivity of existing analytical methodologies in an easy-to-handle and cost-effective manner, without changing and/or minimally altering the original procedures of the existing techniques.
FILED	Tuesday, November 27, 2018
APPL NO	16/765441
ART UNIT	1785 — Miscellaneous Articles, Stock Material
CURRENT CPC	Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 27/06 (20130101) Original (OR) Class B32B 2307/422 (20130101)
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11352379 — Cyclic germanium compounds and applications thereof

US 11352379	Braddock-Wilking et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	The Curators Of The University Of Missouri (Columbia, Missouri)
ASSIGNEE(S)	The Curators Of The University Of Missouri (Columbia, Missouri)
INVENTOR(S)	Janet Braddock-Wilking (St. Louis, Missouri); Teresa Lynn Bandrowsky (St. Peters, Missouri); James Bryan Carroll, II (St. Louis, Missouri)
ABSTRACT	The present disclosure provides a new series of compounds exhibiting high fluorescence quantum yields in the solid state. In one embodiment, the compounds include a series of 2,3,4,5-tetraphenylgermoles with the same or different 1,1-substituents. In another embodiment, substituted germafluorenes, germa-fluoresceins/rhodamines, and germapins are described. These germanium heterocycles possess ideal photophysical and thermostability properties, which makes them excellent candidates for chemical or biological sensors, host materials for electroluminescent devices and solar cells, and emissive and/or electron-transport layer components in organic light emitting diode devices.
FILED	Friday, March 29, 2019
APPL NO	16/369752
ART UNIT	1796 — Organic Chemistry
CURRENT CPC	Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/30 (20130101) Original (OR) Class Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) C09K 2211/1007 (20130101) C09K 2211/1014 (20130101) C09K 2211/1029 (20130101) C09K 2211/1051 (20130101) C09K 2211/1092 (20130101) C09K 2211/1096 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/90 (20130101) Technical Subjects Covered by Former US Classification Y10T 436/202499 (20150115)
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11352606 — Low oxygen tension enhances endothelial fate of human pluripotent stem cells

US 11352606	Gerecht et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Heart, Lung, and Blood Institute (NHLBI) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S)	THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland)
ASSIGNEE(S)	The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S)	Sharon Gerecht (Baltimore, Maryland); Sravanti Kusuma (Baltimore, Maryland)
ABSTRACT	Low oxygen tension is a critical regulator of the developing or regenerating vasculature. The present invention is based on the determination that low oxygen tension during early stages of early vascular cell (EVC) derivation induces endothelial commitment and maturation of pluripotent stem cells. Inhibition of reactive oxygen species generation during the early stages of differentiation abrogates the endothelial inductive effects of the low oxygen environments. Methods of generating various types of cells from pluripotent stem cells (PSCs) are described, as well as compositions and methods of use thereof. In particular, generation of EVCs, bicellular vascular populations, early endothelial cells (ECs) and pericytes via culture in a low oxygen environment is described.
FILED	Monday, March 17, 2014
APPL NO	15/115718
ART UNIT	1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/44 (20130101) A61K 35/545 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/069 (20130101) Original (OR) Class C12N 2500/02 (20130101) C12N 2501/15 (20130101) C12N 2501/165 (20130101) C12N 2506/02 (20130101) C12N 2506/45 (20130101) C12N 2533/54 (20130101)
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11352705 — Hydrocarbon oxidation by water oxidation electrocatalysts in non-aqueous solvents

US 11352705	Hunter et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
ASSIGNEE(S)	California Institute of Technology (Pasadena, California)
INVENTOR(S)	Bryan M. Hunter (Pasadena, California); Harry B. Gray (Pasadena, California)
ABSTRACT	Processes and systems for oxidation of a hydrocarbon reactant to generate an oxidized hydrocarbon product may include: contacting a water oxidation electrocatalyst with the hydrocarbon reactant and water in the presence of a non-aqueous solvent; wherein an anodic bias is applied to the water oxidation electrocatalyst, thereby generating the oxidized hydrocarbon product; and wherein the water oxidation electrocatalyst comprises one or more transition metals other than Ru. Optionally, the water is provided in the non-aqueous solvent at a concentration less than or equal to 0.5 vol. %. Optionally, the magnitude of the anodic bias is selected to generate the oxidized hydrocarbon product characterized by selected product distribution.
FILED	Friday, August 11, 2017
APPL NO	15/675065
ART UNIT	1795 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 3/23 (20210101) C25B 11/051 (20210101) C25B 11/057 (20210101) C25B 11/091 (20210101) Original (OR) Class
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11353361 — Methods, systems, and apparatuses for accurate measurement of health relevant UV exposure from sunlight

US 11353361	Dumont et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Industrial Innovation and Partnerships (IIP)
APPLICANT(S)	YouV Labs, Inc. (New York, New York)
ASSIGNEE(S)	YouV Labs, Inc. (New York, New York)
INVENTOR(S)	Emmanuel Dumont (New York, New York); Peter Kaplan (Montclair, New Jersey)
ABSTRACT	Methods of accurately estimating erythemaly-weighted UV exposure, such as the UV Index, and sensors adapted for the same.
FILED	Friday, May 21, 2021
APPL NO	17/327361
ART UNIT	2884 — Optics
CURRENT CPC	Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 1/16 (20130101) G01J 1/44 (20130101) G01J 1/429 (20130101) Original (OR) Class G01J 1/0488 (20130101) G01J 2001/444 (20130101) G01J 2001/1657 (20130101)
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11353362 — Integration of optical components within a folded optical path

US 11353362	Scholtz et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Industrial Innovation and Partnerships (IIP)
APPLICANT(S)	CHROMATION INC. (Bronx, New York)
ASSIGNEE(S)	CHROMATION INC. (Bronx, New York)
INVENTOR(S)	James Scholtz (Jamesport, New York); Nadia Pervez (Houston, Texas); Ioannis Kymissis (New York, New York); Michael Gazes (Forest Hills, New York)
ABSTRACT	An apparatus includes a substrate transmissive of electromagnetic energy of at least a plurality of wavelengths, having a first end, a second end, a first major face, a second major face, at least one edge, a length, a width, and a thickness, at least a first output optic that outputs electromagnetic energy the substrate; and a first input optic oriented and positioned to provide electromagnetic energy into the substrate via at least one of the first or the second major face of the substrate. The first output optic is laterally spaced from the first input optic. A number of reflectors and optional absorbers may be positioned proximate the first major face and/or the second major face to structure electromagnetic energy and/or to translate such from the first input optic to the first output optic. The apparatus may be part of a spectrometer or other optical system.
FILED	Monday, November 16, 2020
APPL NO	17/099425
ART UNIT	2886 — Optics
CURRENT CPC	Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/0208 (20130101) Original (OR) Class G01J 3/0237 (20130101) G01J 3/0254 (20130101) Optical Elements, Systems, or Apparatus G02B 6/122 (20130101) G02B 6/29365 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/377 (20130101)
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11353435 — Zwitterionic compounds as gas chromatographic column stationary phases

US 11353435	Anderson et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	Iowa State University Research Foundation, Inc. (Ames, Iowa)
ASSIGNEE(S)	Iowa State University Research Foundation, Inc. (Ames, Iowa)
INVENTOR(S)	Jared L. Anderson (Ames, Iowa); Kosuke Kuroda (Kanazawa, Japan); He Nan (Ames, Iowa)
ABSTRACT	A gas chromatographic (GC) column using a zwitterionic compound and methods of use thereof are disclosed herein. The volatile free acids were observed to strongly retain on these zwitterionic compounds-based columns with excellent peak symmetry. By carefully tuning the structures of these zwitterionic compounds, different selectivity toward volatile free acids was demonstrated. These stationary phases possess a wide working range with thermal stabilities at higher temperatures.
FILED	Friday, December 21, 2018
APPL NO	16/229962
ART UNIT	1625 — Organic Chemistry
CURRENT CPC	Separation B01D 15/36 (20130101) Heterocyclic Compounds C07D 233/60 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/56 (20130101) Original (OR) Class G01N 30/68 (20130101) G01N 30/72 (20130101) G01N 30/74 (20130101) G01N 2030/025 (20130101) G01N 2030/562 (20130101)
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11353625 — Systems and methods for forecasting lightning and severe storms

US 11353625	Mecikalski
FUNDED BY	National Science Foundation (NSF) Directorate of Geosciences (GEO) Division of Atmospheric Sciences (ATM)
APPLICANT(S)	John R. Mecikalski (Madison, Alabama)
ASSIGNEE(S)	BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA, FOR AND ON BEHALF OF THE UNIVERSITY OF ALABAMA IN HUNTSVILLE (Huntsville, Alabama)
INVENTOR(S)	John R. Mecikalski (Madison, Alabama)
ABSTRACT	A weather forecasting system has weather forecasting logic that receives weather data from a satellite or other source, such as radar. The weather forecasting logic processes such data to identify cumulus clouds. For each cumulus cloud identified, the weather forecasting logic applies interest field tests and feeds the results into formulas derived based on measurements from current and past weather events. The model determines a score indicating the likelihood of the cumulus cloud forming precipitation and a score indicating the likelihood of the cumulus cloud forming lightning in the future within a certain time period. Based on such scores, the weather forecasting logic predicts in which geographic regions the identified cumulus cloud will produce precipitation and/or lightning during the time period. The predictions of the weather forecasting logic may then be used to provide a weather map thereby providing users with a graphical illustration of the areas.
FILED	Thursday, August 06, 2020
APPL NO	16/987268
ART UNIT	2829 — Semiconductors/Memory
CURRENT CPC	Meteorology G01W 1/10 (20130101) G01W 1/16 (20130101) Original (OR) Class
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11353827 — Optical local oscillator for all-optical time scales, and associated timekeeping methods

US 11353827	Ye et al.
FUNDED BY	Department of Commerce (DOC) Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Physics (PHY)
APPLICANT(S)	The Regents of the University of Colorado, a body corporate (Denver, Colorado); Government of the United States of America as represented by the Secretary of Commerce (Gaithersburg, Maryland)
ASSIGNEE(S)	The Regents of the Univ. of Colorado, a body corp. (Denver, Colorado); Government of the United States of America, as represented by the Secretary of Commerse (Gaithersburg, Maryland)
INVENTOR(S)	Jun Ye (Louisville, Colorado); Eric G. Oelker (Boulder, Colorado); William R. Milner (Boulder, Colorado); John M. Robinson (Henderson, Nevada); Colin J. Kennedy (Boulder, Colorado); Tobias Bothwell (Boulder, Colorado); Dhruv Kedar (Boulder, Colorado); Terry Brown (Lafayette, Colorado)
ABSTRACT	The frequency stability of an optical local oscillator is improved by locking a laser to a silicon Fabry-Perot cavity operating at a temperature near 124 K, where the coefficient of thermal expansion of silicon is near zero. The cavity is mounted inside a cryostat housed in a temperature-stabilized vacuum system that is surrounded by an isolating enclosure and supported by an active vibration platform. Laser light is steered with a superpolished mirror toward a superpolished focusing optic that couples the laser light into the cavity. Light reflected from the cavity is used to stabilize the laser via the Pound-Drever-Hall technique, while light transmitted through the cavity is used to stabilize the laser power. A resonant transimpedance amplifier allows the laser power to be reduced, which reduces heating of the cavity caused by residual absorption of the light.
FILED	Friday, December 18, 2020
APPL NO	17/127616
ART UNIT	2849 — Optics
CURRENT CPC	Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/00 (20130101) G01J 3/45 (20130101) G01J 3/108 (20130101) Time-interval Measuring G04F 5/14 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/15 (20130101) Automatic Control, Starting, Synchronisation, or Stabilisation of Generators of Electronic Oscillations or Pulses H03L 7/26 (20130101) Transmission H04B 10/516 (20130101)
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11355167 — Circuits and methods for in-memory computing

US 11355167	Seok et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computing and Communication Foundations (CCF)
APPLICANT(S)	The Trustees of Columbia University in the City of New York (New York, New York)
ASSIGNEE(S)	The Trustees of Columbia University in the City of New York (New York, New York)
INVENTOR(S)	Mingoo Seok (Tenafly, New Jersey); Zhewei Jiang (Oakland Gardens, New York); Jae-sun Seo (Tempe, Arizona); Shihui Yin (Mesa, Arizona)
ABSTRACT	In some embodiments, an in-memory-computing SRAM macro based on capacitive-coupling computing (C3) (which is referred to herein as “C3SRAM”) is provided. In some embodiments, a C3SRAM macro can support array-level fully parallel computation, multi-bit outputs, and configurable multi-bit inputs. The macro can include circuits embedded in bitcells and peripherals to perform hardware acceleration for neural networks with binarized weights and activations in some embodiments. In some embodiments, the macro utilizes analog-mixed-signal capacitive-coupling computing to evaluate the main computations of binary neural networks, binary-multiply-and-accumulate operations. Without needing to access the stored weights by individual row, the macro can assert all of its rows simultaneously and form an analog voltage at the read bitline node through capacitive voltage division, in some embodiments. With one analog-to-digital converter (ADC) per column, the macro cab realize fully parallel vector-matrix multiplication in a single cycle in accordance with some embodiments.
FILED	Wednesday, June 23, 2021
APPL NO	17/356211
ART UNIT	2827 — Semiconductors/Memory
CURRENT CPC	Electric Digital Data Processing G06F 7/501 (20130101) G06F 7/5443 (20130101) Static Stores G11C 7/1036 (20130101) Original (OR) Class G11C 7/1051 (20130101) G11C 7/1078 (20130101) G11C 15/04 (20130101) G11C 15/043 (20130101) G11C 16/3404 (20130101)
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11355218 — Patient-specific cellular pathway activity inference computer system

US 11355218	Vaske et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of General Medical Sciences (NIGMS) National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Biological Infrastructure (DBI)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	THF REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Charles J. Vaske (Santa Cruz, California); Stephen C. Benz (Santa Cruz, California); Joshua M. Stuart (Santa Cruz, California); David Haussler (Santa Cruz, California)
ABSTRACT	The present invention relates to methods for evaluating the probability that a patient's diagnosis may be treated with a particular clinical regimen or therapy.
FILED	Wednesday, August 02, 2017
APPL NO	15/667544
ART UNIT	3619 — Semiconductors/Memory
CURRENT CPC	Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) G16B 5/30 (20190201) Original (OR) Class G16B 25/00 (20190201) G16B 25/10 (20190201) G16B 40/00 (20190201) G16B 40/30 (20190201) Technologies for Adaptation to Climate Change Y02A 90/10 (20180101)
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11355668 — Photonic materials

US 11355668	Zhao et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	Ohio State Innovation Foundation (Columbus, Ohio)
ASSIGNEE(S)	Ohio State Innovation Foundation (Columbus, Ohio)
INVENTOR(S)	Hongping Zhao (Columbus, Ohio); Md Rezaul Karim (Columbus, Ohio)
ABSTRACT	Disclosed herein are photonic materials. The photonic materials can comprise: a first layer comprising In_xGa_1-xN, wherein x is from 0 to 0.5; a second layer comprising ZnSnN₂; and a third layer comprising In_yGa_1-yN, wherein y is from 0 to 0.5; wherein the second layer is disposed between and in contact with the first layer and the third layer, such that the second layer is sandwiched between the first layer and the third layer. In some examples, the photonic materials can be sandwiched between two or more barrier layers to form a quantum well.
FILED	Monday, November 12, 2018
APPL NO	16/763356
ART UNIT	2891 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 33/06 (20130101) Original (OR) Class H01L 33/26 (20130101) H01L 33/32 (20130101)
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11355774 — Thermally-drawn fiber including electrochemically active gels

US 11355774	Lee et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Jung Tae Lee (Cambridge, United Kingdom); Benjamin Jean-Baptiste Grena (San Francisco, California); Tural Khudiyev (Revere, Massachusetts); Chong Hou (Wuhan, China PRC); Yoel Fink (Brookline, Massachusetts)
ABSTRACT	Provided herein is a fiber having a fiber body including fiber body material with a longitudinal-axis fiber body length. A plurality of gel domains is disposed within the fiber body along at least a portion of the longitudinal-axis fiber body length. Each gel domain includes a porous host matrix material and a liquid gel component that is entrapped in the molecular structure of the host matrix material and that is disposed in interstices of the host material matrix. At least two of the gel domains within the fiber body are disposed directly adjacent to each other in direct physical contact with each other. This fiber can include polymeric fiber body material and gel domains including a porous polymer host matrix material and an ionically conducting liquid solvent that is entrapped in the molecular structure of the polymer host matrix material and disposed in interstices of the polymer host material matrix.
FILED	Thursday, March 21, 2019
APPL NO	16/361157
ART UNIT	1725 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/485 (20130101) H01M 4/5825 (20130101) H01M 10/02 (20130101) Original (OR) Class H01M 10/0565 (20130101) H01M 2004/023 (20130101) H01M 2004/025 (20130101) H01M 2300/0085 (20130101)
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11356100 — FPGA with reconfigurable threshold logic gates for improved performance, power, and area

US 11356100	Vrudhula et al.
FUNDED BY	National Science Foundation (NSF) Directorate of Technology, Innovation and Partnerships (TIP) Translational Impacts (TI)
APPLICANT(S)	Sarma Vrudhula (Chandler, Arizona); Ankit Wagle (Tempe, Arizona)
ASSIGNEE(S)	ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona)
INVENTOR(S)	Sarma Vrudhula (Chandler, Arizona); Ankit Wagle (Tempe, Arizona)
ABSTRACT	A field-programmable gate array (FPGA) with reconfigurable threshold logic gates for improved performance, power, and area (PPA) is provided. This disclosure describes a new architecture for an FPGA, referred to as threshold logic FPGA (TLFPGA), that integrates a conventional lookup table (LUT) with a complementary metal-oxide-semiconductor (CMOS) digital implementation of a binary perceptron, referred to as a threshold logic cell (TLC). The TLFPGA design described herein, combined with a new logic mapping algorithm that exploits the presence of both conventional LUTs and TLCs within the basic logic element (BLE) block, achieves significant improvements in all the metrics of PPA. The TLCs of embodiments described herein are capable of implementing a complex threshold function, which if implemented using conventional gates would require several levels of logic gates. The TLCs only require seven static random-access memory (SRAM) cells and are significantly faster than the conventional LUTs.
FILED	Sunday, July 12, 2020
APPL NO	16/926718
ART UNIT	2844 — Electrical Circuits and Systems
CURRENT CPC	Electric Digital Data Processing G06F 30/343 (20200101) G06F 30/347 (20200101) G06F 2119/06 (20200101) Pulse Technique H03K 19/17728 (20130101) Original (OR) Class H03K 19/17744 (20130101) H03K 19/17796 (20130101)
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11356235 — Self-interference cancellation for in-band full duplex single antenna communication systems

US 11356235	Smida et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computing and Communication Foundations (CCF)
APPLICANT(S)	THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
ASSIGNEE(S)	THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
INVENTOR(S)	Besma Smida (Chicago, Illinois); Danilo Erricolo (Chicago, Illinois); Seiran Khaledian (Chicago, Illinois); Farhad Farzami (Chicago, Illinois)
ABSTRACT	An analog self-interference cancellation technique for In-Band Full-Duplex (IBFD) systems generates an inherent secondary self-interference (SI) signal of a circulator and uses that signal to cancel a primary SI signal leaked from a transmitter port within a communication device. The communication device manipulates the phase and angle of this secondary SI, using an adjustable Impedance Mismatch Terminal (IMT) circuit. The result is an efficient SI cancellation technique in the analog domain, which uses the circulator inherent SI signals.
FILED	Thursday, May 24, 2018
APPL NO	16/616192
ART UNIT	2476 — Multiplex and VoIP
CURRENT CPC	Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 1/38 (20130101) Impedance Networks, e.g Resonant Circuits; Resonators H03H 11/28 (20130101) Transmission H04B 1/58 (20130101) H04B 1/525 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 5/1461 (20130101) Original (OR) Class
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11356593 — Methods and systems for single frame autofocusing based on color- multiplexed illumination

US 11356593	Zheng
FUNDED BY	National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Biological Infrastructure (DBI) Directorate of Technology, Innovation and Partnerships (TIP) Translational Impacts (TI)
APPLICANT(S)	University of Connecticut (Farmington, Connecticut)
ASSIGNEE(S)	University of Connecticut (Farmington, Connecticut)
INVENTOR(S)	Guoan Zheng (Vernon, Connecticut)
ABSTRACT	The present disclosure includes systems and methods for capture a whole slide image of a sample. In exemplary embodiments, a camera is configured to capture a digital image of a sample. The system captures a bright field image of the sample, and captures a digital image of the sample illuminated from a first incident angle at a first wavelength and a second incident angle at a second wavelength. The system can determine whether the sample is defocused based on the transitional shift between a first wavelength channel and a second wavelength channel of the captured digital image. The system can determine the defocus distance based on the transitional shift and autofocus using the defocus distance such the bright field image is in focus.
FILED	Thursday, May 07, 2020
APPL NO	16/869190
ART UNIT	2485 — Recording and Compression
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 21/006 (20130101) G02B 21/12 (20130101) G02B 21/0064 (20130101) G02B 21/0072 (20130101) G02B 21/365 (20130101) Image Data Processing or Generation, in General G06T 7/70 (20170101) G06T 7/557 (20170101) G06T 7/571 (20170101) G06T 7/586 (20170101) Pictorial Communication, e.g Television H04N 5/23212 (20130101) Original (OR) Class H04N 5/23232 (20130101)
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11356650 — Calibration arrangement for structured light system using a tele-centric lens

US 11356650	Zhang et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S)	Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S)	Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S)	Song Zhang (West Lafayette, Indiana); Beiwen Li (Lafayette, Indiana)
ABSTRACT	A vision system having a telecentric lens. The vision system includes a projector having a non-telecentric pin-hole lens, a camera having a telecentric lens positioned a distance away from the projector, and a processor. The processor controls the camera and the projector and is configured to calibrate the camera and projector.
FILED	Monday, July 29, 2019
APPL NO	16/524761
ART UNIT	2481 — Recording and Compression
CURRENT CPC	Image Data Processing or Generation, in General G06T 7/80 (20170101) G06T 7/521 (20170101) G06T 2207/30208 (20130101) Pictorial Communication, e.g Television H04N 13/204 (20180501) Original (OR) Class H04N 17/002 (20130101)
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Department of Energy (DOE)

11351478 — Oil skimmer with oleophilic coating

US 11351478	Darling et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Argonne National Laboratory (ANL) Federally Funded Research and Development Center (FFRDC) Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
APPLICANT(S)	UCHICAGO ARGONNE LLC (Chicago, Illinois)
ASSIGNEE(S)	UChicago Argonne, LLC (Chicago, Illinois)
INVENTOR(S)	Seth B. Darling (Chicago, Illinois); Jeffrey W. Elam (Elmhurst, Illinois)
ABSTRACT	A method of fabricating an coating includes providing a coating comprising a base material. The base material is coated with an inorganic material using at least one of an atomic layer deposition (ALD), a molecular layer deposition (MLD), or sequential infiltration synthesis (SIS) process. The SIS process includes at least one cycle of exposing the coating to a first metal precursor for a first predetermined time and a first partial pressure. The first metal precursor infiltrates at least a portion of the base material and binds with the base material. The coating is exposed to a second co-reactant precursor for a second predetermined time and a second partial pressure. The second co-reactant precursor reacts with the first metal precursor, thereby forming the inorganic material on the base material. The inorganic material infiltrating at least the portion of the base material. The inorganic material is functionalized with a material.
FILED	Thursday, September 06, 2018
APPL NO	16/123382
ART UNIT	1779 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC	Separation B01D 17/0202 (20130101) Original (OR) Class Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/40 (20130101) C02F 1/285 (20130101) C02F 1/288 (20130101) C02F 2101/32 (20130101) C02F 2103/007 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/45525 (20130101) Hydraulic Engineering E02B 15/10 (20130101) E02B 15/045 (20130101) E02B 15/102 (20130101) E02B 15/104 (20130101)
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11351514 — Parallelized multiple nozzle system and method to produce layered droplets and fibers for microencapsulation

US 11351514	Ye et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S)	Lawrence Livermore National Security, LLC (Livermore, California)
INVENTOR(S)	Congwang Ye (Livermore, California); Julie A. Mancini (Livermore, California); Kevin Scott Paulsen (Oakland, California); William Smith (Oakland, California)
ABSTRACT	The present disclosure relates to a nozzle system for use in a microfluidic production application for producing at least one of particles, capsules or fibers. The system has a main body portion having a compressed fluid inlet and a core fluid inlet, and a plurality of parallel arranged core fluid nozzles that receive the core fluid and create a plurality of core fluid streams. At least one compressed fluid inlet associated with the main body channels compressed fluid to areas adjacent ends of the core fluid nozzles. An apertured plate having a plurality of apertures is arranged near the ends of the core fluid nozzles, with each aperture being uniquely associated with a single one of the core fluid nozzles. The compressed fluid acts on the core fluid streams exiting the core fluid nozzles to help create, with the apertures, at least one of core fluid droplets or core fluid fibers from the core fluid streams.
FILED	Thursday, July 02, 2020
APPL NO	16/920083
ART UNIT	1743 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 2/02 (20130101) Original (OR) Class
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11352712 — Method for controlling fiber growth in a laser heated pedestal growth system by controlling a laser power output, a pedestal feedstock rate of motion, and a draw rate

US 11352712	Buric et al.
FUNDED BY	Department of Energy (DOE) Office of Fossil Energy and Carbon Management (FECM) National Energy Technology Laboratory (NETL)
APPLICANT(S)	Energy, United States Department of (Washington, District of Columbia)
ASSIGNEE(S)	Energy, United States Department of (Washington, District of Columbia)
INVENTOR(S)	Michael P. Buric (Pittsburgh, Pennsylvania); Bo Liu (Morgantown, West Virginia)
ABSTRACT	One or more embodiments relate to a method for controlling fiber growth and fiber diameter in a laser heated pedestal growth (LHPG) system so as to provide long, continuous single-crystal optical fibers of uniform diameter. The method generally provides three independent parameter feedback controls to control the molten zone height, laser power, and fiber drawing rates simultaneously in order to reduce the mismatch between instantaneous diameter changes and current diameter. The method permits the growth of fibers with non-uniform diameters along the fiber's length. The method also provides the capability to stop the LHPG system, remove the exhausted pedestal feedstock with a second pedestal feedstock, and restart the LHPG system to provide a continuous fiber.
FILED	Thursday, March 28, 2019
APPL NO	16/368425
ART UNIT	1714 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC	Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 13/22 (20130101) C30B 13/30 (20130101) Original (OR) Class Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/1636 (20130101) H01S 3/1643 (20130101)
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11353150 — System for sealing flanged connections

US 11353150	Baffes
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Fermi National Accelerator Laboratory (FNAL) Federally Funded Research and Development Center (FFRDC) Operated by Fermi Research Alliance, LLC (FRA) at Batavia, IL
APPLICANT(S)	Fermi Research Alliance, LLC (Batavia, Illinois)
ASSIGNEE(S)	FERMI RESEARCH ALLIANCE, LLC (Batavia, Illinois)
INVENTOR(S)	Curtis M Baffes (Batavia, Illinois)
ABSTRACT	A flange sealing system can include a loading member layer adapted to receive a sealing force thereon, at least one intermediate member receiving the sealing force from the loading member and adapted to distribute the load force to branch members in subsequent layers, and at least one contact member adapted to apply the sealing force evenly around a flange and press a surface of the flange and against at least one of a second flange surface or a cap to seal an opening associated with the flange via at least one of connection to the second flange surface or the cap. The system can be provided in the form of a first pipe receiving section and a second pipe receiving section for securing two flanges together with associated pipes with pivot points distributed about the first and second pipe receiving section and distributing even pressure around the flanges.
FILED	Wednesday, May 29, 2019
APPL NO	16/425222
ART UNIT	3679 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware
CURRENT CPC	Pipes; Joints or Fittings for Pipes; Supports for Pipes, Cables or Protective Tubing; Means for Thermal Insulation in General F16L 23/18 (20130101) F16L 23/036 (20130101) Original (OR) Class
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11353266 — Multi-zone shell and tube heat exchanger

US 11353266	Sabau et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Oak Ridge National Laboratory (ORNL) Federally Funded Research and Development Center (FFRDC) Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S)	UT-BATTELLE, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)	UT-BATTELLE, LLC (Oak Ridge, Tennessee)
INVENTOR(S)	Adrian S. Sabau (Knoxville, Tennessee); James W. Klett (Knoxville, Tennessee); Yarom Polsky (Knoxville, Tennessee)
ABSTRACT	A shell and tube heat exchanger has elongated shell having first and second opposing ends and an open interior. A core divides the open interior of the shell into first and second enclosed portions. The shell has first and second tube fluid openings at opposing ends. End plates divide the first and second enclosed portions into manifold portions and enclosed shell chamber portions. Tubes extend from the end plates, through the enclosed shell chambers to the core. Shell fluid openings are at sides of the elongated shell, a first fluid opening communicating with the first shell chamber, and a second fluid opening communicating with the second shell chamber. The shell has a long axis, and the end plates are angled relative to the long axis. The tubes are polygonal with rounded corners and straight sides. The heat exchanger can be used for both evaporation and condensation processes.
FILED	Tuesday, September 29, 2020
APPL NO	17/036392
ART UNIT	3763 — Refrigeration, Vaporization, Ventilation, and Combustion
CURRENT CPC	Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 7/10 (20130101) Original (OR) Class
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11353383 — Shock test assembly

US 11353383	Busenitz et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Kansas City National Security Campus (KCNSC) NNSA Critical Mission Site Operated by Honeywell Federal Manufacturing & Technologies, LLC (FM&T) at Kansas City, MO
APPLICANT(S)	Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri)
ASSIGNEE(S)	Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri)
INVENTOR(S)	Clark Busenitz (Overland Park, Kansas); Weston A. McGuire (Overland Park, Kansas)
ABSTRACT	An assembly for shock testing a specimen, the assembly including first and second opposing brackets and opposing lower and upper caps. The opposing brackets include lower and upper angled surfaces. The lower cap includes lower angled surfaces configured to engage the lower angled surfaces of the left and right brackets. The upper cap includes upper angled surfaces configured to engage the upper angled surfaces of the left and right brackets. The first and second brackets are configured to be drawn toward each other via fasteners, thereby wedging the lower and upper caps toward each other against the specimen.
FILED	Tuesday, January 28, 2020
APPL NO	16/774354
ART UNIT	2855 — Printing/Measuring and Testing
CURRENT CPC	Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 7/08 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 3/04 (20130101) Original (OR) Class G01N 3/30 (20130101) G01N 2203/026 (20130101) G01N 2203/0256 (20130101) G01N 2203/0405 (20130101) G01N 2203/0482 (20130101) G01N 2203/0676 (20130101) Measuring Linear or Angular Speed, Acceleration, Deceleration, or Shock; Indicating Presence, Absence, or Direction, of Movement G01P 15/18 (20130101)
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11353467 — Use of lipid particles in medical diagnostics

US 11353467	Louie et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Katherine B. Louie (Walnut Creek, California); Benjamin P. Bowen (Walnut Creek, California); Trent R. Northen (Walnut Creek, California)
ABSTRACT	Disclosed herein are methods for identifying one or more diseased cells in a subject. Some embodiments include providing a biological sample derived from a subject, analyzing the biological sample by mass spectrometry, and determining the abundance of one or more lipids in the biological sample, wherein an altered abundance of the one or more lipids in the biological sample, as compared to a reference level, indicates a presence of one or more diseased cells in the subject from which the biological sample is derived.
FILED	Thursday, January 23, 2014
APPL NO	14/761587
ART UNIT	1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/92 (20130101) Original (OR) Class G01N 33/574 (20130101) G01N 2405/04 (20130101) G01N 2405/08 (20130101) G01N 2458/15 (20130101) G01N 2560/00 (20130101) G01N 2800/7028 (20130101)
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11355005 — Aquatic organism tracking devices, systems and associated methods

US 11355005	Deng et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Pacific Northwest National Laboratory (PNNL) Federally Funded Research and Development Center (FFRDC) Operated by Battelle Memorial Institute (BMI) at Richland, WA
APPLICANT(S)	Battelle Memorial Institute (Richland, Washington)
ASSIGNEE(S)	Battelle Memorial Institute (Richland, Washington)
INVENTOR(S)	Z. Daniel Deng (Richland, Washington); Huidong Li (Richland, Washington); Jun Lu (Richland, Washington); Jayson J. Martinez (Kennewick, Washington)
ABSTRACT	Aquatic organism tracking devices, systems and associated methods are described. According to one aspect, an aquatic organism tracking device includes a housing, a transducer coupled with the housing and configured to transmit a data transmission externally of the housing and an aquatic organism associated with the tracking device, a programmable oscillator coupled with the housing, and wherein the programmable oscillator is configured to generate a clock signal having a selected one of a plurality of different frequencies, processing circuitry coupled with the housing and configured to receive the clock signal from the programmable oscillator and to execute a plurality of executable instructions according to the clock signal, a power source coupled with the housing and configured to store electrical energy, and wherein the processing circuitry is configured to control the provision of the electrical energy from the power source to the transducer to generate the data transmission as a result of the execution of the instructions.
FILED	Thursday, July 16, 2020
APPL NO	16/930846
ART UNIT	2687 — Dynamic Storage Systems; Mechanical parts of Disk Drives
CURRENT CPC	Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 11/006 (20130101) Transmission Systems for Measured Values, Control or Similar Signals G08C 17/02 (20130101) Original (OR) Class G08C 2201/12 (20130101)
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11355252 — Control rod drive mechanism with heat pipe cooling

US 11355252	Lobscheid et al.
FUNDED BY	Department of Energy (DOE) Office of Nuclear Energy (DOE-NE)
APPLICANT(S)	NuScale Power, LLC (Corvallis, Oregon)
ASSIGNEE(S)	NUSCALE POWER, LLC (Corvallis, Oregon)
INVENTOR(S)	Christian Lobscheid (Corvallis, Oregon); Derek Noel (Albany, Oregon)
ABSTRACT	A representative cooling system for a nuclear reactor control rod drive mechanism (CRDM) includes an evaporation section located within or next to the CRDM and a condensation section fluidly coupled to the evaporation section. The cooling system includes a set of heat fins coupled to drive coils in the CRDM and heat pipes that extend through the drive coils and heat fins. A fluid evaporates while in the evaporation section of the heat pipes from heat generated by the CRDM and moves out of the evaporation section into the condensation section in the heat fins. The fluid cools and condensates while in the condensation section, recirculating back into the evaporation section. This passive natural circulation cooling system reduces or eliminates the number of water hoses, piping, and other water pumping equipment typically used for cooling a CRDM thereby increasing nuclear reactor reliability and simplifying nuclear reactor operation and maintenance.
FILED	Friday, December 21, 2018
APPL NO	16/229554
ART UNIT	3646 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Nuclear Reactors G21C 7/14 (20130101) Original (OR) Class G21C 15/257 (20130101) Dynamo-electric Machines H02K 9/20 (20130101)
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11355253 — Passive techniques for long-term reactor cooling

US 11355253	Malloy, III et al.
FUNDED BY	Department of Energy (DOE)
APPLICANT(S)	BWXT mPower, Inc. (Charlotte, North Carolina)
ASSIGNEE(S)	BWXT mPower, Inc. (Charlotte, North Carolina)
INVENTOR(S)	John D. Malloy, III (Goode, Virginia); Billy E. Bingham (Lynchburg, Virginia); Ronald C. Watson (Forest, Virginia); Jason G. Williams (Concord, Virginia); Matthew W. Ales (Puyallup, Washington); James B. Inman (Forest, Virginia); Sean M. Boyle (Charlotte, North Carolina)
ABSTRACT	In a pressurized water reactor (PWR), emergency core cooling (ECC) responds to depressurization due to a vessel penetration break at the top of the pressure vessel by draining water from a body of water through an injection line into the pressure vessel. A barrier operates concurrently with the ECC to suppress flow of liquid water from the pressure vessel out the vessel penetration break. The barrier may comprise one or more of: (1) an injection line extension passing through the central riser to drain water into the central riser; (2) openings in a lower portion of a central riser to shunt some upward flow from the central riser into a lower portion of the downcomer annulus; and (3) a surge line providing fluid communication between a pressurizer volume at the top of the pressure vessel and the remainder of the pressure vessel which directs water outboard toward the downcomer annulus.
FILED	Monday, July 20, 2020
APPL NO	16/933498
ART UNIT	3619 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Nuclear Reactors G21C 1/09 (20130101) G21C 1/32 (20130101) G21C 1/322 (20130101) G21C 15/18 (20130101) Original (OR) Class G21C 15/26 (20130101)
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11355336 — Time-resolved chemical studies via time-of-flight secondary ion mass spectrometry

US 11355336	Ievlev et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Oak Ridge National Laboratory (ORNL) Federally Funded Research and Development Center (FFRDC) Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S)	UT-BATTELLE, LLC (Oak Ridge, Pennsylvania); University of Tennessee Research Foundation (Knoxville, Tennessee)
ASSIGNEE(S)	UT-BATTELLE, LLC (Oak Ridge, Tennessee); UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (Knoxville, Tennessee)
INVENTOR(S)	Anton V. Ievlev (Knoxville, Tennessee); Olga S. Ovchinnikova (Knoxville, Tennessee); Matthias Lorenz (Toronto, Canada); Yongtao Liu (Knoxville, Tennessee)
ABSTRACT	A method of performing time-of-flight secondary ion mass spectrometry on a sample includes the step of directing a beam of primary ions to the sample, and stimulating the migration of ions within the sample while the beam of primary ions is directed at the sample. The stimulation of the ions is cycled between a stimulation state and a lower stimulation state. Secondary ions emitted from the sample by the beam of primary ions are collected in a time-of-flight mass spectrometer. Time-of-flight secondary ion mass spectrometry is then performed on the secondary ions. A system for performing time-of-flight secondary ion mass spectrometry on a sample is also disclosed.
FILED	Friday, February 12, 2021
APPL NO	17/174968
ART UNIT	2881 — Optics
CURRENT CPC	Electric Discharge Tubes or Discharge Lamps H01J 49/022 (20130101) H01J 49/0031 (20130101) H01J 49/408 (20130101) Original (OR) Class
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11355690 — Superconducting qubit devices based on metal silicides

US 11355690	Black et al.
FUNDED BY	Department of Energy (DOE) Brookhaven Science Associates, LLC (BSA) Office of Science (DOE-SC) Brookhaven National Laboratory (BNL) Federally Funded Research and Development Center (FFRDC) Operated by Brookhaven Science Associates, LLC (BSA) at Upton, NY
APPLICANT(S)	Brookhaven Science Associates, LLC (Upton, New York)
ASSIGNEE(S)	Brookhaven Science Associates, LLC (Upton, New York)
INVENTOR(S)	Charles T. Black (New York, New York); Mingzhao Liu (Syosset, New York)
ABSTRACT	A qubit device for use in a quantum computing environment includes a semiconductor substrate, an insulating layer disposed on at least a portion of an upper surface of the substrate, and a transition metal silicide (TMSi) heterojunction disposed on at least a portion of an upper surface of the insulating layer. The TMSi heterojunction includes a link layer and at least first and second TMSi regions coupled with the link layer. The link layer may include a normal conductor, thereby forming a superconductor-normal conductor-superconductor (SNS) junction, or a geometric constriction, thereby forming a superconductor-geometric constriction-superconductor (ScS) junction. The link layer may form at least a portion of a channel including intrinsic or doped silicon.
FILED	Friday, March 06, 2020
APPL NO	16/811278
ART UNIT	2896 — Semiconductors/Memory
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) B82Y 40/00 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 39/025 (20130101) H01L 39/223 (20130101) Original (OR) Class H01L 39/2493 (20130101)
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11355697 — Nanometer scale nonvolatile memory device and method for storing binary and quantum memory states

US 11355697	Xiao et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) SLAC National Accelerator Laboratory (SLAC) Federally Funded Research and Development Center (FFRDC) Operated by Stanford University (LSJU) at Menlo Park, CA
APPLICANT(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
INVENTOR(S)	Jun Xiao (Stanford, California); Aaron Lindenberg (Stanford, California)
ABSTRACT	Example implementations include an electronic memory device with a metallic layer having a first planar crystalline structure, a first encapsulating layer including an encapsulating material having a second planar crystalline structure, and disposed adjacent to a first planar surface of the metallic layer, and a second encapsulating layer including the encapsulating material, and disposed adjacent to a second planar surface of the metallic layer. Example implementations also include a method of depositing graphite crystals onto a substrate to form a gate bottom layer, depositing BN crystals onto the graphite bottom layer to form a BN bottom layer, depositing tungsten ditelluride (WTe₂) crystals onto the BN bottom layer to form a metallic layer, depositing the BN crystals onto the BN bottom layer and the metallic layer to form a BN top layer, and depositing the graphite crystals onto the BN top layer to form a gate top layer.
FILED	Tuesday, November 24, 2020
APPL NO	17/103710
ART UNIT	2827 — Semiconductors/Memory
CURRENT CPC	Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Static Stores G11C 11/18 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/228 (20130101) H01L 43/04 (20130101) H01L 43/06 (20130101) Original (OR) Class H01L 43/10 (20130101) H01L 43/14 (20130101)
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11355747 — Nanoporous carbon as host material for sodium

US 11355747	Harrison et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	Katharine Lee Harrison (Albuquerque, New Mexico); Michael Siegal (Albuquerque, New Mexico); Matthaeus Wolak (Albuquerque, New Mexico); Paul Cuillier (Columbus, Ohio)
ABSTRACT	Nanoporous carbon can provide a binderless, three-dimensional form of graphene as a host material for sodium-ion batteries or supercapacitors.
FILED	Wednesday, January 08, 2020
APPL NO	16/737104
ART UNIT	1729 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/24 (20130101) H01G 11/32 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/366 (20130101) Original (OR) Class H01M 4/587 (20130101) H01M 4/628 (20130101) H01M 10/054 (20130101) H01M 2004/021 (20130101) H01M 2004/027 (20130101)
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11355817 — Nanoporous separators for batteries and related manufacturing methods

US 11355817	Carlson et al.
FUNDED BY	Department of Energy (DOE)
APPLICANT(S)	LG ENERGY SOLUTION, LTD. (Seoul, South Korea)
ASSIGNEE(S)	LG ENERGY SOLUTION, LTD. (Seoul, South Korea)
INVENTOR(S)	Steven A. Carlson (Cambridge, Massachusetts); Benjamin Sloan (Exeter, New Hampshire); David W. Avison (Boxborough, Massachusetts)
ABSTRACT	Provided is a lithium battery, wherein the battery comprises an anode, a cathode, wherein the cathode comprises one or more transition metals, an electrolyte, and a porous separator interposed between the cathode and anode, wherein the separator comprises an anionic compound. Also provided are methods of manufacturing such batteries.
FILED	Thursday, June 03, 2021
APPL NO	17/338214
ART UNIT	1725 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/20 (20130101) H01G 11/50 (20130101) H01G 11/52 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 10/052 (20130101) H01M 10/0525 (20130101) H01M 10/0585 (20130101) H01M 50/46 (20210101) H01M 50/446 (20210101) Original (OR) Class Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/13 (20130101)
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11355824 — Detection of an internal short circuit in a battery

US 11355824	Stefanopoulou et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA) U.S. Army Tank Automotive Research, Development and Engineering Center (TARDEC) Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S)	The Regents of The University of Michigan (Ann Arbor, Michigan)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
INVENTOR(S)	Anna G. Stefanopoulou (Ann Arbor, Michigan); Jason B. Siegel (Ann Arbor, Michigan); Sravan Pannala (Ann Arbor, Michigan); Gregory B. Less (Ypsilanti, Michigan); Ting Cai (Ann Arbor, Michigan); Mingxuan Zhang (Beijing, China PRC)
ABSTRACT	An electrical device comprises a battery cell; a pressure sensor for measuring swelling forces of the battery cell, optionally with voltage, temperature and current sensors, and a battery management system including a controller. The controller executes a program to: (i) determine a reference swelling force corresponding to a reference electrical signal received from the pressure sensor at an earlier reference time, (ii) determine a second swelling force corresponding to a second electrical signal received from the pressure sensor at a later second time, and (iii) determine whether a risk of internal short circuit of the battery cell exists by comparing a reference level of the reference electrical signal and a signal representative of the second electrical signal. When the signal representative of the second electrical signal exceeds the reference level of the reference electrical signal by a threshold amount, a risk of internal short circuit of the cell exists.
FILED	Monday, May 13, 2019
APPL NO	16/410714
ART UNIT	1722 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 58/12 (20190201) Measuring Electric Variables; Measuring Magnetic Variables G01R 31/52 (20200101) G01R 31/3648 (20130101) G01R 31/3842 (20190101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/486 (20130101) H01M 10/0525 (20130101) H01M 10/4257 (20130101) H01M 50/578 (20210101) Original (OR) Class H01M 2010/4271 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

11355930 — Phase identification using statistical analysis

US 11355930	Veda et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE) National Renewable Energy Laboratory (NREL) Federally Funded Research and Development Center (FFRDC) Operated by Alliance for Sustainable Energy, LLC (ASE) at Golden, CO
APPLICANT(S)	Alliance for Sustainable Energy, LLC (Golden, Colorado)
ASSIGNEE(S)	Alliance for Sustainable Energy, LLC (Golden, Colorado)
INVENTOR(S)	Santosh Sambamoorthy Veda (Littleton, Colorado); Surya Chandan Dhulipala (Gainesville, Florida); Murali Mohan Baggu Data Venkata Satya (Golden, Colorado); Harsha Vardhana Padullaparti (Lakewood, Colorado)
ABSTRACT	A device includes at least one processor configured to determine, based on (i) a first plurality of time-varying electrical measurements corresponding to a feeder head of a power distribution network having a plurality of phases and (ii) a second plurality of time-varying electrical measurements corresponding to a node in the power distribution network, and using statistical analysis, a predicted phase, from the plurality of phases, that corresponds to the node. The processor may be configured to use ranked correlation coefficients (such as the Kendall rank correlation coefficient) to determine the predicted phase and may use principle component analysis. The processor is also configured to cause at least one device of the power distribution network to modify operation based at least on part on the predicted phase.
FILED	Thursday, June 18, 2020
APPL NO	16/905490
ART UNIT	2119 — Computer Error Control, Reliability, & Control Systems
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 21/133 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/004 (20200101) Original (OR) Class H02J 3/16 (20130101) H02J 3/28 (20130101) H02J 2203/20 (20200101)
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11356015 — Modular medium voltage fast chargers

US 11356015	Lukic et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S)	NORTH CAROLINA STATE UNIVERSITY (Raleigh, North Carolina)
ASSIGNEE(S)	North Carolina State University (Raleigh, North Carolina)
INVENTOR(S)	Srdjan Lukic (Raleigh, North Carolina); Xinyu Liang (Raleigh, North Carolina); Chi Zhang (Apex, North Carolina); Srdjan Srdic (Vienna, Austria)
ABSTRACT	Certain embodiments involve a modular medium voltage fast charger. The modular medium voltage fast charger can include: (1) a predictive power factor correction (“PFC”) controller (or predictive controller) for series-interleaved multi-cell three-level boost (“SIMCB”) converters, (2) an active neutral point clamped (“NPC”) dual active bridge (“DAB”) modulation scheme to achieve soft switching, (3) an auxiliary capacitor to reduce NPC DAB turn-off voltages, (4) a comprehensive and scalable protection circuit, and (5) a high-isolation pulse transformer with a bobbin for reducing coupling capacitance of the pulse transformer.
FILED	Wednesday, May 09, 2018
APPL NO	16/611773
ART UNIT	2839 — Computer Error Control, Reliability, & Control Systems
CURRENT CPC	Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 19/00 (20130101) H01F 27/325 (20130101) Emergency Protective Circuit Arrangements H02H 3/02 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 7/06 (20130101) Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/007 (20210501) H02M 1/12 (20130101) H02M 1/14 (20130101) H02M 1/0074 (20210501) H02M 1/4208 (20130101) H02M 1/4225 (20130101) H02M 1/4233 (20130101) H02M 1/4258 (20130101) Original (OR) Class H02M 3/1584 (20130101) H02M 3/33584 (20130101) H02M 7/49 (20130101) H02M 7/487 (20130101)
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National Aeronautics and Space Administration (NASA)

11351609 — Synthesis of tungsten tetraboride

US 11351609	Spradling et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) NASA Shared Services Center (NSSC)
APPLICANT(S)	Millennitek, LLC (Knoxville, Tennessee)
ASSIGNEE(S)	Millennitek LLC (Knoxville, Tennessee)
INVENTOR(S)	Andrew M. Spradling (Knoxville, Tennessee); Lawrence W. Townsend (Knoxville, Tennessee)
ABSTRACT	A method of forming tungsten tetraboride, by combining tungsten and boron in a molar ratio of from about 1:6 to about 1:12, respectively, and firing the combined tungsten and boron in the hexagonal boron nitride crucible at a temperature of from about 1600 C to about 2000 C, to form tungsten tetraboride.
FILED	Wednesday, July 15, 2020
APPL NO	16/947015
ART UNIT	1738 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 3/12 (20130101) B22F 9/04 (20130101) Original (OR) Class B22F 2009/041 (20130101) B22F 2201/11 (20130101) B22F 2201/20 (20130101) B22F 2202/13 (20130101) B22F 2302/05 (20130101) Non-metallic Elements; Compounds Thereof; C01B 35/04 (20130101) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/58064 (20130101) Alloys C22C 1/051 (20130101) C22C 29/14 (20130101) Nuclear Reactors G21C 11/028 (20130101) Protection Against X-radiation, Gamma Radiation, Corpuscular Radiation or Particle Bombardment; Treating Radioactively Contaminated Material; Decontamination Arrangements Therefor G21F 1/06 (20130101) G21F 1/085 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

11351613 — Magnetic elements and methods for the additive manufacture thereof

US 11351613	Firdosy et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) Jet Propulsion Laboratory (JPL) Federally Funded Research and Development Center (FFRDC) Operated by California Institute of Technology (CALTECH) at Pasadena, CA
APPLICANT(S)	California Institute of Technology (Pasadena, California)
ASSIGNEE(S)	California Institute of Technology (Pasadena, California)
INVENTOR(S)	Samad A. Firdosy (La Crescenta, California); Robert P. Dillon (Long Beach, California); Ryan W. Conversano (Tarzana, California); John Paul C. Borgonia (Monrovia, California); Andrew A. Shapiro-Scharlotta (Glendale, California); Bryan W. McEnerney (Redondo Beach, California); Adam Herrmann (Piqua, Ohio)
ABSTRACT	Elements formed from magnetic materials and their methods of manufacture are presented. Magnetic materials include a magnetic alloy material, such as, for example, an Fe—Co alloy material (e.g., the Fe—Co—V alloy Hiperco-50®). The magnetic alloy materials may comprise a powdered material suitable for use in additive manufacturing techniques, such as, for example direct energy deposition or laser powder bed fusion. Manufacturing techniques include the use of variable deposition time and energy to control the magnetic and structural properties of the materials by altering the microstructure and residual stresses within the material. Manufacturing techniques also include post deposition processing, such as, for example, machining and heat treating. Heat treating may include a multi-step process during which the material is heated, held and then cooled in a series of controlled steps such that a specific history of stored internal energy is created within the material. Magnetic elements may include, for example, motors, generators, solenoids and switches, sensors, transformers, and hall thrusters, among other elements.
FILED	Monday, June 03, 2019
APPL NO	16/429986
ART UNIT	1733 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/20 (20210101) Original (OR) Class B22F 2003/248 (20130101) Alloys C22C 33/0207 (20130101) C22C 38/10 (20130101) C22C 2202/02 (20130101)
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11351628 — On-line phased array ultrasonic testing system for friction stir welding applications

US 11351628	Huggett et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) Marshall Space Flight Center (MSFC)
APPLICANT(S)	Daniel J. Huggett (Denham Springs, Louisiana); Mohammad W. Dewan (Baton Rouge, Louisiana); Muhammad A. Wahab (Baton Rouge, Louisiana); Thunshun W. Liao (Baton Rouge, Louisiana); Ayman M. Okeil (Baton Rouge, Louisiana)
ASSIGNEE(S)	BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (Baton Rouge, Louisiana)
INVENTOR(S)	Daniel J. Huggett (Denham Springs, Louisiana); Mohammad W. Dewan (Baton Rouge, Louisiana); Muhammad A. Wahab (Baton Rouge, Louisiana); Thunshun W. Liao (Baton Rouge, Louisiana); Ayman M. Okeil (Baton Rouge, Louisiana)
ABSTRACT	A wedge for on-line inspection of a weld includes a wedge body defining a coolant channel and at least one couplant channel, and a coolant input port in fluid connection with a first end of the coolant channel. The wedge body has a surface for disposing a phased array ultrasonic transducer comprising an array of ultrasonic elements. The coolant channel is formed in proximity to the surface for disposing the phased array ultrasonic transducer such that coolant flowing through the coolant channel maintains the phased array ultrasonic transducer below a predetermined temperature without obstructing the array of ultrasonic elements.
FILED	Thursday, February 09, 2017
APPL NO	16/075000
ART UNIT	2861 — Printing/Measuring and Testing
CURRENT CPC	Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 20/123 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/07 (20130101) G01N 29/11 (20130101) G01N 29/28 (20130101) G01N 29/069 (20130101) G01N 29/221 (20130101) G01N 29/262 (20130101) G01N 29/265 (20130101) G01N 29/326 (20130101) G01N 29/0645 (20130101) G01N 29/2437 (20130101) G01N 2291/106 (20130101) G01N 2291/2675 (20130101)
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11352693 — Boron aluminum oxide compound deposited by atomic layer deposition on product used for radiation shielding

US 11352693	Dwivedi
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	United States of America as represented by the Administrator of NASA (Washington, District of Columbia)
ASSIGNEE(S)	United States of America as represented by the Administrator of NASA (Washington, District of Columbia)
INVENTOR(S)	Vivek Dwivedi (Greenbelt, Maryland)
ABSTRACT	The present invention relates to utilizing atomic layer deposition (ALD) techniques to deposit a layer of boron compound in a light-weight composite carbon-based foam derived from natural precursors, graphene, or other carbon-based materials, to minimize the effects of radiation in space applications. A method of manufacturing radiation shielding material includes: preparing a carbon-based foam product in a predetermined volume; and doping the carbon-based foam product by depositing a boron or boron-10 aluminum oxide (B/B¹⁰—Al—O) compound using ALD in a vacuum chamber on either carbon-based foam or spherical silica particles prior to generating a carbon-based foam; wherein doping the carbon-based foam product includes depositing the boron¹⁰-Al—O compound at a thickness of between one and two atomic percent of boron-10 within the carbon-based foam or on the silica particles; or coating a percentage of average foam pores (50% of average foam pore diameter) of the carbon-based foam product with the boron¹⁰-Al—O compound.
FILED	Friday, April 24, 2020
APPL NO	16/857641
ART UNIT	1718 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC	Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/26 (20130101) C23C 16/045 (20130101) C23C 16/403 (20130101) Original (OR) Class C23C 16/4408 (20130101) C23C 16/4417 (20130101) C23C 16/45555 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

11353152 — Fluid transfer couplings and methods therefor

US 11353152	Hawk et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	United States of America as represented by the Administrator of NASA (Washington, District of Columbia)
ASSIGNEE(S)	United States of America as represented by the Administrator of NASA (Washington, District of Columbia)
INVENTOR(S)	Douglas Hawk (Beltsville, Maryland); Hans Raven (Beltsville, Maryland); Matthew Ashmore (Beltsville, Maryland); Hsiao Smith (Greenbelt, Maryland); Tim Horner (Beltsville, Maryland)
ABSTRACT	The present invention relates to couplers for transferring fluid between space assets, particularly in a vacuum microgravity environment with radiation exposure. In particular, the couplers provide for transfer of fluids, such as propellants, coolants, pressurant gases, or life-support fluids, preferably between assets in the space environment or in terrestrial environments such as Earth, the Moon, or Mars. The couplers provide self-alignment features which enable their use in blind-mate, telerobotic, fully autonomous robotic systems. The invention provides a common design architecture for different fluids accommodating a variety of flow rates and pressure drops depending upon the particular fluid. The basic wetted component design of the invention involves a rigid, centrally-disposed nozzle on the Passive Side which contacts and opens a poppet valve on the Active Side as the two sides are coupled; and a rigid annular nozzle on the Active Side, coaxially located with but occupying a different radius than the Passive Side nozzle, which contacts and opens a corresponding contamination cover on the Passive Side.
FILED	Friday, March 27, 2020
APPL NO	16/831959
ART UNIT	3753 — Fluid Handling and Dispensing
CURRENT CPC	Cosmonautics; Vehicles or Equipment Therefor B64G 1/648 (20130101) Pipes; Joints or Fittings for Pipes; Supports for Pipes, Cables or Protective Tubing; Means for Thermal Insulation in General F16L 37/40 (20130101) Original (OR) Class F16L 53/35 (20180101) F16L 58/185 (20130101) F16L 2201/40 (20130101)
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11353240 — Low drag, variable-depth acoustic liner

US 11353240	Schiller et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA (Washington, District of Columbia)
ASSIGNEE(S)	UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA (Washington, District of Columbia)
INVENTOR(S)	Noah H. Schiller (Yorktown, Virginia); Michael G Jones (Newport News, Virginia); Brian M. Howerton (Carrollton, Virginia); Douglas M. Nark (Norfolk, Virginia)
ABSTRACT	Systems and devices of the various embodiments may provide a low-drag, variable-depth acoustic liner having shared inlet volumes. Various embodiments may include a low-drag, variable-depth acoustic liner providing aircraft noise reduction. Acoustic liners according to the various embodiments may be used in engine nacelles and/or on external surfaces of an aircraft to reduce acoustic radiation. Acoustic liners according to various embodiments may provide increased broadband acoustic performance with less drag than conventional liners. Various embodiments may provide an acoustic liner with a reduced open area of the facesheet, and therefore reduced drag of the liner, when compared with conventional acoustic liners.
FILED	Friday, September 27, 2019
APPL NO	16/585291
ART UNIT	2837 — Electrical Circuits and Systems
CURRENT CPC	Vehicles, Vehicle Fittings, or Vehicle Parts, Not Otherwise Provided for B60R 13/08 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 33/02 (20130101) B64D 2033/0206 (20130101) B64D 2033/0286 (20130101) Air-conditioning; Air-humidification; Ventilation; Use of Air Currents for Screening F24F 13/24 (20130101) Original (OR) Class F24F 2013/242 (20130101) Sound-producing Devices; Methods or Devices for Protecting Against, or for Damping, Noise or Other Acoustic Waves in General; Acoustics Not Otherwise Provided for G10K 11/162 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

11353524 — Optical fiber-based distributed sensing of magnetic field gradients

US 11353524	Strutner et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	United States of America as Represented by the Administrator of NASA (Washington, District of Columbia)
ASSIGNEE(S)	U.S.A, as Represented by the Administrator of the National Aeronautics and Space Administration (Washington, District of Columbia)
INVENTOR(S)	Scott Michael Strutner (Los Angeles, California); Anthony Barra (Corona del Mar, California); Gregory Paul Carman (Los Angeles, California); William Lance Richards (Lancaster, California); Francisco Peña (Pasadena, California)
ABSTRACT	A system for measuring magnetic field gradients comprising a multi-bay support structure with a series of raised contact shoulders separated from each other by voids. An optical fiber is spaced along the length of the multi-cell support structure and traverses all the raised contact points and voids. The optical fiber has a plurality of Fiber Bragg gratings (FBGs) spaced lengthwise, each FBG suspended in a void. In addition, a plurality of ferromagnetic members are strung onto the optical fiber, each suspended in a void. Magnetic field gradients act on the ferromagnetic member to create localized tension in the optical fiber. The FBG's refractive indices are monitored, tension is calculated therefrom, and the tension is correlated to the magnetic field gradient. This greatly simplifies mechanical, optical, electronic and computational complexity and is bay suited for any FOSS array for measuring magnetic fields using many dense measurement points.
FILED	Monday, July 20, 2020
APPL NO	16/933572
ART UNIT	2858 — Printing/Measuring and Testing
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 33/0327 (20130101) Original (OR) Class
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11353918 — Asynchronous timing exchange for redundant clock synchronization

US 11353918	Mautner et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) Johnson Space Center (JSC)
APPLICANT(S)	THE CHARLES STARK DRAPER LABORATORY, INC. (Cambridge, Massachusetts)
ASSIGNEE(S)	THE CHARLES STARK DRAPER LABORATORY, INC. (Cambridge, Massachusetts)
INVENTOR(S)	Eric Karl Mautner (Hudson, Massachusetts); Brianna Klingensmith (Arlington, Massachusetts)
ABSTRACT	The present disclosure relates to systems and methods to maintain clock synchronization of multiple computers, or computer systems, through the exchange of communication messages that include clock and/or timing information.
FILED	Thursday, July 25, 2019
APPL NO	16/522137
ART UNIT	2465 — Multiplex and VoIP
CURRENT CPC	Electric Digital Data Processing G06F 1/12 (20130101) G06F 1/14 (20130101) Original (OR) Class G06F 13/42 (20130101) G06F 13/122 (20130101) Automatic Control, Starting, Synchronisation, or Stabilisation of Generators of Electronic Oscillations or Pulses H03L 7/0814 (20130101) H03L 7/0991 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 7/0025 (20130101) H04L 7/0037 (20130101)
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11355328 — Systems and methods for isolating a target ion in an ion trap using a dual frequency waveform

US 11355328	Cooks et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) NASA Shared Services Center (NSSC)
APPLICANT(S)	Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S)	Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S)	Robert Graham Cooks (West Lafayette, Indiana); Dalton Snyder (West Lafayette, Indiana)
ABSTRACT	The invention generally relates to systems and methods for isolating a target ion in an ion trap. In certain aspects, the invention provides a system that includes a mass spectrometer having an ion trap, and a central processing unit (CPU). The CPU includes storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply a dual frequency waveform to the ion trap that ejects non-target ions from the ion trap while retaining a target ion in the ion trap.
FILED	Thursday, April 13, 2017
APPL NO	16/073993
ART UNIT	2881 — Optics
CURRENT CPC	Electric Discharge Tubes or Discharge Lamps H01J 49/0031 (20130101) Original (OR) Class H01J 49/42 (20130101) H01J 49/426 (20130101)
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11355895 — Connector demate tools

US 11355895	Mitchell
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	Goodrich Corporation (Charlotte, North Carolina)
ASSIGNEE(S)	Goodrich Corporation (Charlotte, North Carolina)
INVENTOR(S)	Michael D. Mitchell (Albuquerque, New Mexico)
ABSTRACT	A tool for demating multi-pin connectors includes a first fork including an inner fork member and an outer fork member operatively connected for relative movement parallel to a longitudinal fork axis. A second fork is spaced apart from the first fork wherein the second fork includes an inner fork member and an outer fork member operatively connected for relative movement parallel to the longitudinal fork axis. A handle connects the first fork to the second fork. The handle includes an outer handle member fixedly connecting the outer fork members of the first and second forks, and the handle includes an inner handle member fixedly connecting the inner fork members of the first and second forks. Relative movement of the inner and outer handle members causes relative movement of the inner and outer fork members of the first and second forks for demating multi-pin electrical connectors from sockets.
FILED	Tuesday, April 14, 2020
APPL NO	16/848154
ART UNIT	3729 — Manufacturing Devices & Processes, Machine Tools & Hand Tools Group Art Units
CURRENT CPC	Tools or Bench Devices Not Otherwise Provided For, for Fastening, Connecting, Disengaging or Holding B25B 27/00 (20130101) Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors H01R 43/26 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

Department of Agriculture (USDA)

11350582 — Plant varieties by application of endocides

US 11350582	Li et al.
FUNDED BY	Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA)
APPLICANT(S)	Stephen F. Austin State University (Nacogdoches, Texas)
ASSIGNEE(S)	Stephen F. Austin State University (Nacogdoches, Texas)
INVENTOR(S)	Shiyou Li (Nacogdoches, Texas); Ping Wang (Nacogdoches, Texas); Zushang Su (Nacogdoches, Texas)
ABSTRACT	The present invention relates generally to compositions and methods for mutating a plant and plants and plant products produced by said methods. Also, compositions and methods for controlling a plant species are disclosed herein.
FILED	Friday, May 08, 2020
APPL NO	16/870481
ART UNIT	1663 — Plants
CURRENT CPC	New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 1/06 (20130101) Original (OR) Class Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 37/40 (20130101) A01N 43/40 (20130101) Mixtures of Fertilisers Covered Individually by Different Subclasses of Class C05; Mixtures of One or More Fertilisers With Materials Not Having a Specific Fertilising Activity, e.g Pesticides, Soil-conditioners, Wetting Agents; Fertilisers Characterised by Their Form C05G 3/00 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

11352416 — Mosaic chimeric viral vaccine particle

US 11352416	Mwangi et al.
FUNDED BY	Department of Agriculture (USDA) Agricultural Research Service (ARS) Cooperative State Research, Education, and Extension Service (CSREES) National Institute of Food and Agriculture (NIFA)
APPLICANT(S)	The Texas A and M University System (College Station, Texas)
ASSIGNEE(S)	The TEXAS A and M UNIVERSITY SYSTEM (College Station, Texas)
INVENTOR(S)	Waithaka Mwangi (College Station, Texas); Surya Waghela (College Station, Texas); Luc Berghman (Collge Station, Texas)
ABSTRACT	The present invention describes compositions and methods for priming protective immunity in the presence of pre-existing maternal antibody. In some embodiments, the invention contemplates simultaneously masking vaccines to avoid antibody neutralization while targeting those vaccines to specific cell types in order to elicit an enhanced immune response. In other embodiments, vectors that recruit and activate specific antigen-presenting cells may further enhance the efficacy of those immune responses.
FILED	Tuesday, November 17, 2020
APPL NO	16/950297
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/761 (20130101) A61K 39/42 (20130101) A61K 2039/55522 (20130101) Peptides C07K 16/081 (20130101) Original (OR) Class C07K 16/1081 (20130101) C07K 16/2851 (20130101) C07K 2317/31 (20130101) C07K 2317/76 (20130101) C07K 2317/622 (20130101) C07K 2317/626 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2710/10343 (20130101) C12N 2770/24334 (20130101) C12N 2810/855 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Department of Homeland Security (DHS)

11353292 — Scalable body armor carrier system for ballistic plates and panels

US 11353292	Bak
FUNDED BY	Department of Homeland Security (DHS)
APPLICANT(S)	The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia)
ASSIGNEE(S)	The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia)
INVENTOR(S)	David Bak (Keedysville, Maryland)
ABSTRACT	In an example, a kit for assembling a scalable body armor for a wearer's body includes hard ballistic plates, soft ballistic panels, a plate carrier including a front plate carrier and a rear plate carrier connected by shoulder straps and having front and rear plate carrier pockets for receiving the hard ballistic plates, a front panel carrier having a front outward facing side joinable to an inward facing side of the front plate carrier by contact and a front panel carrier pocket to receive one of the soft ballistic panels, and a rear panel carrier having a rear outward facing side joinable to an inward facing side of the rear plate carrier by contact and a rear panel carrier pocket to receive another one of the soft ballistic panels.
FILED	Monday, October 18, 2021
APPL NO	17/504055
ART UNIT	3641 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Armour; Armoured Turrets; Armoured or Armed Vehicles; Means of Attack or Defence, e.g Camouflage, in General F41H 1/02 (20130101) Original (OR) Class F41H 5/013 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

11354446 — Peer integrity checking system

US 11354446	Trent et al.
FUNDED BY	Department of Homeland Security (DHS)
APPLICANT(S)	Architecture Technology Corporation (Minneapolis, Minnesota)
ASSIGNEE(S)	Architecture Technology Corporation (Minneapolis, Minnesota)
INVENTOR(S)	Barry A. Trent (Chanhassen, Minnesota); Edward R. Mandy (Victoria, Minnesota)
ABSTRACT	A distributed file integrity checking system is described. The described peer integrity checking system (PICS) may negate an attack by storing a properties database amongst nodes of a peer-to-peer network of hosts, some or all of which co-operate to protect and watch over each other.
FILED	Friday, March 20, 2020
APPL NO	16/825548
ART UNIT	2491 — Cryptography and Security
CURRENT CPC	Electric Digital Data Processing G06F 21/64 (20130101) Original (OR) Class G06F 21/568 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 67/104 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Department of Veterans Affairs (DVA)

11352315 — Compositions and methods comprising a triaryl polyamine

US 11352315	Looper et al.
FUNDED BY	Department of Defense (DOD) Uniformed Services University of the Health Sciences (USUHS) Henry M Jackson Foundation for the Advancement of Military Medicine, Inc (HJF) Department of Veterans Affairs (DVA)
APPLICANT(S)	Curza Global, LLC (Provo, Utah); University of Utah Research Foundation (Salt Lake City, Utah)
ASSIGNEE(S)	Curza Global, LLC (Provo, Utah); University of Utah Research Foundation (Salt Lake City, Utah)
INVENTOR(S)	Ryan E. Looper (Salt Lake City, Utah); Dustin Williams (Bountiful, Utah); Paul R. Sebahar (Sandy, Utah); Travis J. Haussener (Salt Lake City, Utah); Hariprasada R. Kanna Reddy (Salt Lake City, Utah)
ABSTRACT	Compounds, compositions, and methods comprising a polyamine compound are described, which may be used to kill, disperse, treat, or reduce biofilms, or to inhibit or substantially prevent biofilm formation. In some aspects, the present invention relates to polyamine compounds that have antimicrobial or dispersing activity against a variety of bacterial strains capable of forming biofilms. In some aspects, the present invention relates to compositions and methods comprising the polyamine compound. In some aspects, the compounds, compositions, and methods enhance wound healing.
FILED	Friday, October 04, 2019
APPL NO	16/593143
ART UNIT	1626 — Organic Chemistry
CURRENT CPC	Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/02 (20180101) Acyclic or Carbocyclic Compounds C07C 211/27 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

11354990 — Treatment of kidney diseases associated with elevated AVP

US 11354990	Kishore et al.
FUNDED BY	Department of Veterans Affairs (DVA)
APPLICANT(S)	United States Government As Represented By The Department of Veterans Affairs (Washington, District of Columbia)
ASSIGNEE(S)	THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (, None)
INVENTOR(S)	Bellamkonda K. Kishore (Sandy, Utah); Yue Zhang (Salt Lake City, Utah); Noel G. Carlson (Salt Lake City, Utah)
ABSTRACT	Disclosed are methods for treating kidney disease including autosomal dominant polycystic kidney disease (ADPKD) in a subject, comprising the step of administering to the subject a composition comprising a therapeutically effective amount of ticagrelor or a derivative thereof, thereby treating ADPKD. Disclosed are methods of decreasing arginine vasopressin (AVP) production in a subject comprising the step of administering to the subject a composition comprising an effective amount of ticagrelor, thereby decreasing AVP production. Disclosed are methods for treating dilutional hyponatremia in a subject comprising the step of administering to the subject a composition comprising an effective amount of ticagrelor, thereby decreasing AVP production.
FILED	Monday, April 06, 2020
APPL NO	16/841098
ART UNIT	1699 — Computer Graphic Processing, 3D Animation, Display Color Attribute, Object Processing, Hardware and Memory
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/55 (20130101) A61K 31/519 (20130101) A61K 31/4365 (20130101) A61K 38/095 (20190101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 13/12 (20180101) Aeroplanes; Helicopters B64C 39/024 (20130101) B64C 2201/127 (20130101) Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 13/196 (20130101) Original (OR) Class Pictorial Communication, e.g Television H04N 7/185 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Small Business Administration (SBA)

11352452 — Articles and methods related to labile crosslinking moieties

US 11352452	Hancock et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Chemical Biological Center (CCDC CBC) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Akita Innovations LLC (Billerica, Massachusetts)
ASSIGNEE(S)	Akita Innovations LLC (Billerica, Massachusetts)
INVENTOR(S)	Lawrence F. Hancock (North Andover, Massachusetts); Richard A. Minns (Arlington, Massachusetts)
ABSTRACT	Articles and methods related to the manufacture of polymers containing labile crosslinking moieties are generally described.
FILED	Wednesday, August 19, 2020
APPL NO	16/997837
ART UNIT	1765 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 8/50 (20130101) Original (OR) Class C08F 130/08 (20130101) C08F 228/02 (20130101) C08F 230/08 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 77/38 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

11352675 — Devices and methods for antibiotic susceptability testing

US 11352675	Ciopyk et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Visby Medical, Inc. (San Jose, California)
ASSIGNEE(S)	VISBY MEDICAL, INC. (San Jose, California)
INVENTOR(S)	Brian Ciopyk (Santa Clara, California); Paul Dentinger (Sunol, California); Teresa Abraham (Washington, District of Columbia); Brandon Ma (Santa Clara, California); Kamal Kajouke (San Jose, California); Mackenzie Hunt (Santa Cruz, California); Austin Phung (San Jose, California)
ABSTRACT	The disclosure relates generally to molecular diagnostic devices configured to amplifying a single nucleotide polymorphism (SNP) locus and discriminate between two or more allelic variants of the SNP, indicating presence or absence of a target allele. In some embodiments, the molecular diagnostic devices are capable of detecting, at point-of-care, SNPs associated with resistance or susceptibility to antibiotic treatment of organism infections. In other aspects, the disclosure provides methods of treatment for disease or disorders (e.g. organism infections) where treatment is guided by presence or absence of an allele at a SNP locus as determined by such molecular diagnostic devices.
FILED	Thursday, December 31, 2020
APPL NO	17/139451
ART UNIT	1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/04 (20130101) C12Q 1/18 (20130101) C12Q 1/689 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

United States Postal Service (USPS)

11352227 — System for transferring articles from a container

US 11352227	Perry-Eaton et al.
FUNDED BY	United States Postal Service (USPS)
APPLICANT(S)	United States Postal Service (Washington, District of Columbia)
ASSIGNEE(S)	United States Postal Service (Washington, District of Columbia)
INVENTOR(S)	Wayne Perry-Eaton (Leesburg, Virginia); George W. Potts, Jr. (Upper Marlboro, Maryland); Daniel Radtke (Madison, Wisconsin)
ABSTRACT	An automated system for transferring articles from a container. An item transfer system includes retainers configured to secure a first tray and a second tray, a movable paddle assembly, a frame, and a plurality of actuators. The system is configured to transfer articles from the first tray to the second tray by an automated process including securing the articles within the first tray with the paddle assembly, rotating the frame by approximately 90° to 100°, moving the paddle assembly in a series of linear translations to remove the items from the first tray and place the items into the second tray, rotating the frame back to its initial orientation, and releasing the items into the second tray.
FILED	Monday, January 11, 2021
APPL NO	17/146367
ART UNIT	3652 — Material and Article Handling
CURRENT CPC	Postal Sorting; Sorting Individual Articles, or Bulk Material Fit to be Sorted Piece-meal, e.g by Picking B07C 3/087 (20130101) Transport or Storage Devices, e.g Conveyors for Loading or Tipping, shop Conveyor Systems Or pneumatic Tube Conveyors B65G 1/137 (20130101) Handling Thin or Filamentary Material, e.g Sheets, Webs, Cables B65H 1/027 (20130101) B65H 5/006 (20130101) B65H 15/02 (20130101) Original (OR) Class B65H 29/02 (20130101) B65H 2301/42242 (20130101) B65H 2301/422542 (20130101) B65H 2301/422548 (20130101) B65H 2701/1916 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

11353858 — Systems and methods for automated guided vehicle control

US 11353858	Shiu et al.
FUNDED BY	United States Postal Service (USPS)
APPLICANT(S)	United States Postal Service (Washington, District of Columbia)
ASSIGNEE(S)	UNITED STATES POSTAL SERVICE (Washington, District of Columbia)
INVENTOR(S)	Leung Man Shiu (Gaithersburg, Maryland); Erich Joseph Petre (Gainesville, Virginia)
ABSTRACT	Systems and methods for commanding, controlling, and guiding automated guided vehicles (“AGVs”). Automated systems translate AGV commands according to AGV manufacturers. AGVs can be summoned and destinations be determined automatically.
FILED	Friday, January 17, 2020
APPL NO	16/746524
ART UNIT	3655 — Material and Article Handling
CURRENT CPC	Transport or Storage Devices, e.g Conveyors for Loading or Tipping, shop Conveyor Systems Or pneumatic Tube Conveyors B65G 1/1371 (20130101) B65G 1/1378 (20130101) B65G 2203/041 (20130101) B65G 2203/042 (20130101) Hoisting, Lifting, Hauling or Pushing, Not Otherwise Provided For, e.g Devices Which Apply a Lifting or Pushing Force Directly to the Surface of a Load B66F 9/063 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 15/04 (20130101) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/41895 (20130101) Original (OR) Class G05B 2219/40298 (20130101) G05B 2219/45063 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 2201/0216 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Department of Commerce (DOC)

11353827 — Optical local oscillator for all-optical time scales, and associated timekeeping methods

US 11353827	Ye et al.
FUNDED BY	Department of Commerce (DOC) Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Physics (PHY)
APPLICANT(S)	The Regents of the University of Colorado, a body corporate (Denver, Colorado); Government of the United States of America as represented by the Secretary of Commerce (Gaithersburg, Maryland)
ASSIGNEE(S)	The Regents of the Univ. of Colorado, a body corp. (Denver, Colorado); Government of the United States of America, as represented by the Secretary of Commerse (Gaithersburg, Maryland)
INVENTOR(S)	Jun Ye (Louisville, Colorado); Eric G. Oelker (Boulder, Colorado); William R. Milner (Boulder, Colorado); John M. Robinson (Henderson, Nevada); Colin J. Kennedy (Boulder, Colorado); Tobias Bothwell (Boulder, Colorado); Dhruv Kedar (Boulder, Colorado); Terry Brown (Lafayette, Colorado)
ABSTRACT	The frequency stability of an optical local oscillator is improved by locking a laser to a silicon Fabry-Perot cavity operating at a temperature near 124 K, where the coefficient of thermal expansion of silicon is near zero. The cavity is mounted inside a cryostat housed in a temperature-stabilized vacuum system that is surrounded by an isolating enclosure and supported by an active vibration platform. Laser light is steered with a superpolished mirror toward a superpolished focusing optic that couples the laser light into the cavity. Light reflected from the cavity is used to stabilize the laser via the Pound-Drever-Hall technique, while light transmitted through the cavity is used to stabilize the laser power. A resonant transimpedance amplifier allows the laser power to be reduced, which reduces heating of the cavity caused by residual absorption of the light.
FILED	Friday, December 18, 2020
APPL NO	17/127616
ART UNIT	2849 — Optics
CURRENT CPC	Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/00 (20130101) G01J 3/45 (20130101) G01J 3/108 (20130101) Time-interval Measuring G04F 5/14 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/15 (20130101) Automatic Control, Starting, Synchronisation, or Stabilisation of Generators of Electronic Oscillations or Pulses H03L 7/26 (20130101) Transmission H04B 10/516 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Environmental Protection Agency (EPA)

11351208 — Altering the intestinal microbiome in cystic fibrosis

US 11351208	O'Toole et al.
FUNDED BY	Environmental Protection Agency (EPA) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) National Institute of Allergy and Infectious Diseases (NIAID) National Institute of Environmental Health Sciences (NIEHS) National Institute of General Medical Sciences (NIGMS) NIH Office of the Director (NIHOD)
APPLICANT(S)	Trustees of Dartmouth College (Hanover, New Hampshire); Dartmouth-Hitchcock Clinic (Lebanon, New Hampshire)
ASSIGNEE(S)	Trastees of Dartmouth College (Hanover, New Hampshire); Dartmouth-Hitchcock Clime (Lebanon, New Hampshire)
INVENTOR(S)	George A. O'Toole (Hanover, New Hampshire); Juliette C. Madan (Lyme, New Hampshire)
ABSTRACT	The present disclosure relates to a method of altering intestinal microbiome in a patient having cystic fibrosis comprising administering at least one of Bifidobacterium and/or Bacteroides to a patient and allowing the Bifidobacterium and/or Bacteroides to alter the intestinal microbiome.
FILED	Tuesday, March 26, 2019
APPL NO	16/979824
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/741 (20130101) A61K 35/744 (20130101) A61K 35/745 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) A61P 11/00 (20180101)
VIEW PATENT	@ USPTO: Full Text PDF

Non-Profit Organization (NPO)

11356925 — Systems and methods of mobile ad hoc network IP roaming

US 11356925	Stevens et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Contracting Command (ACC) Non-Profit Organization (NPO) National Spectrum Consortium (NSC)
APPLICANT(S)	Rockwell Collins, Inc. (Cedar Rapids, Iowa)
ASSIGNEE(S)	Rockwell Collins, Inc. (Cedar Rapids, Iowa)
INVENTOR(S)	James A. Stevens (Cedar Rapids, Iowa); Jeffrey D. Bouis (Cedar Rapids, Iowa); Naveen Rajanikantha (Cedar Rapids, Iowa)
ABSTRACT	A network device includes at least one of a baseband interface or a loopback interface, a wireless radio frequency (RF) interface, and a processing circuit. The baseband interface is coupled to a first node. The wireless RF interface is coupled to a second node. The processing circuit assigns a routable address to the at least one of the baseband interface or the loopback interface, assigns a non-routable address to the first node based on the first node being a gateway interface, assigns a routable address to the first node based on the first node not being a gateway interface, and assigns a non-routable address to the second node based on the second node being coupled to the wireless RF interface.
FILED	Thursday, December 19, 2019
APPL NO	16/721763
ART UNIT	2412 — Multiplex and VoIP
CURRENT CPC	Transmission H04B 1/0003 (20130101) Wireless Communication Networks H04W 40/248 (20130101) Original (OR) Class H04W 80/02 (20130101) H04W 84/18 (20130101) H04W 92/06 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Office of the Director of National Intelligence (ODNI)

11353479 — Laser-assisted device alteration using synchronized laser pulses

US 11353479	Vedagarbha et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL) Office of the Director of National Intelligence (ODNI) Intelligence Advanced Research Projects Activity (IARPA)
APPLICANT(S)	FEI EFA, Inc. (Fremont, California)
ASSIGNEE(S)	FEI EFA, Inc. (Fremont, California)
INVENTOR(S)	Praveen Vedagarbha (Fremont, California); Derryck Reid (Blackridge, United Kingdom); Keith Serrels (Fremont, California); James S. Vickers (San Jose, California)
ABSTRACT	A pulsed-laser LADA system is provided, which utilizes temporal resolution to enhance spatial resolution. The system is capable of resolving CMOS pairs within the illumination spot using synchronization of laser pulses with the DUT clock. The system can be implemented using laser wavelength having photon energy above the silicon bandgap so as to perform single-photon LADA or wavelength having photon energy below the silicon bandgap so as to generate two-photon LADA. The timing of the laser pulses can be adjusted using two feedback loops tied to the clock signal of an ATE, or by adjusting the ATE's clock signal with reference to a fixed-pulse laser source.
FILED	Tuesday, January 15, 2019
APPL NO	16/248423
ART UNIT	2896 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 1/07 (20130101) Original (OR) Class G01R 31/26 (20130101) G01R 31/30 (20130101) G01R 31/311 (20130101) G01R 31/31917 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

U.S. State Government

11352602 — Microalgae adapted for heterotrophic culture conditions

US 11352602	Wee et al.
FUNDED BY	U.S. State Government State of California California Energy Commission (CEC)
APPLICANT(S)	Corbion Biotech, Inc. (South San Francisco, California)
ASSIGNEE(S)	Corbion Biotech, Inc. (South San Francisco, California)
INVENTOR(S)	Janice Lau Wee (South San Francisco, California); Dawei Yuan (South San Francisco, California); Wenhua Lu (South San Francisco, California); Rika Regentin (South San Francisco, California); Jeffrey Villari (South San Francisco, California)
ABSTRACT	The present invention provides methods for making microalgal strains with improved properties relative to the strains from which they are derived. In illustrative embodiments, the methods are performed to produce microalgal strains adapted for use in the industrial production of microalgae-derived biomass products, including but not limited to triglycerides and fatty acids. Also provided are microalgal strains, which can be obtained using the methods described herein, as wells microalgal-derived biomass products, which can be produced from such microalgal strains.
FILED	Wednesday, March 30, 2016
APPL NO	15/562356
ART UNIT	1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/36 (20130101) Original (OR) Class C12N 1/125 (20210501) C12N 9/24 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/64 (20130101) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/89 (20210501)
VIEW PATENT	@ USPTO: Full Text PDF

Government Rights Acknowledged

11352892 — Seal element for sealing a joint between a rotor blade and a rotor disk

US 11352892	Virkler
FUNDED BY
APPLICANT(S)	Raytheon Technologies Corporation (Farmington, Connecticut)
ASSIGNEE(S)	Raytheon Technologies Corporation (Farmington, Connecticut)
INVENTOR(S)	Scott D. Virkler (Ellington, Connecticut)
ABSTRACT	A rotor assembly is provided for a piece of rotational equipment. This rotor assembly includes a rotor disk, a rotor blade and a seal element. The rotor disk is configured to rotate about a rotational axis. The rotor disk extends axially along the rotational axis to a rotor disk end face. The rotor blade includes an attachment. The attachment attaches the rotor blade to the rotor disk. The seal element is configured to seal a gap between the rotor disk and the attachment. The seal element has a longitudinal centerline that extends along an interface between the rotor disk and the attachment at the rotor disk end face.
FILED	Friday, April 17, 2020
APPL NO	16/851832
ART UNIT	3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/3015 (20130101) Original (OR) Class F01D 11/006 (20130101) Indexing Scheme Relating to Wind, Spring, Weight, Inertia or Like Motors, to Machines or Engines for Liquids Covered by Subclasses F03B, F03D and F03G F05B 2240/57 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

11352903 — Rotor stack bushing with adaptive temperature metering for a gas turbine engine

US 11352903	Pratt et al.
FUNDED BY
APPLICANT(S)	United Technologies Corporation (Farmington, Connecticut)
ASSIGNEE(S)	RAYTHEON TECHNOLOGIES CORPORATION (Farmington, Connecticut)
INVENTOR(S)	William S. Pratt (West Hartford, Connecticut); Matthew E. Bintz (West Hartford, Connecticut); Weston Behling (Norwalk, Connecticut); Kevin N. McCusker (West Hartford, Connecticut); Erica J. Harvie (Middletown, Connecticut)
ABSTRACT	A rotor stack for a gas turbine engine includes a first rotor disk with a first rotor spacer arm, the first rotor spacer arm having a first flange with an outboard flange surface and an inboard flange surface, a first hole along an axis through the first flange, the first hole having a counterbore in the outboard flange surface; a second rotor disk with a web having a second hole along the axis; a third rotor disk with a third rotor spacer arm, the third rotor spacer arm having a third flange with an outboard flange surface and an inboard flange surface, a third hole along the axis through the third flange, the third hole having a counterbore in the inboard flange surface; and a bushing with a tubular body and a flange that extends therefrom, the tubular body comprising at least one axial groove along an outer diameter thereof, the bushing extends through the first hole, the second hole and partially into the counterbore in the inboard flange surface of the third hole.
FILED	Monday, January 20, 2020
APPL NO	16/747065
ART UNIT	3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 25/12 (20130101) F01D 25/125 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

How To Use This Page

THE FEDINVENT PATENT DETAILS PAGE

Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.

This week's information is published in the FedInvent Patents report for Tuesday, June 07, 2022.

The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week’s taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.

HOW IS THE INFORMATION ORGANIZED?

Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.

WHAT INFORMATION WILL I FIND?

THE PANEL
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FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:

Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)

We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.

APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.

Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer funded innovation is happening in America. Here are two examples from two different patents:

APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC

APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)

INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.

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FILED
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APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.

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3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices

You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.

CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.

The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.

The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.

A61B 1/149 (20130101)
A61B 1/71 (20130101)
A61B 1/105 (20130101)

The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full-text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.

VIEW PATENT
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