FedInvent™ Patents
Patent Details for Tuesday, September 20, 2022
This page was updated on Thursday, September 29, 2022 at 04:58 PM GMT
Department of Health and Human Services (HHS)
| US 11445912 | Dharmakumar et al. |
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| FUNDED BY |
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| APPLICANT(S) | Cedars-Sinai Medical Center (Los Angeles, California) |
| ASSIGNEE(S) | Cedars-Sinai Medical Center (Los Angeles, California) |
| INVENTOR(S) | Rohan Dharmakumar (Moorpark, California); Hsin-Jung Yang (Los Angeles, California) |
| ABSTRACT | The invention provides various methods for imaging a subject's cardiovascular system. The imaging method may be used to provide a diagnosis or prognosis of various cardiovascular diseases in the subject, without contrast agents or radioactive tracers, and further generating a Gaussian Mixture Model to obtain a reference value of a normal myocardium. |
| FILED | Friday, September 30, 2016 |
| APPL NO | 15/763669 |
| ART UNIT | 3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0044 (20130101) Original (OR) Class A61B 5/055 (20130101) A61B 5/02007 (20130101) A61B 5/7207 (20130101) A61B 5/14542 (20130101) A61B 6/03 (20130101) A61B 6/037 (20130101) A61B 6/503 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/50 (20130101) G01R 33/481 (20130101) G01R 33/5601 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11445914 | Gallippi et al. |
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| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (Chapel Hill, North Carolina) |
| INVENTOR(S) | Caterina M. Gallippi (Cary, North Carolina); Christopher Joseph Moore (Durham, North Carolina); Md Murad Hossain (Chapel Hill, North Carolina); Tomasz Joseph Czernuszewicz (Chapel Hill, North Carolina) |
| ABSTRACT | Methods, systems, and computer readable media for taking measurements of a material, including determining material anisotropy, are provided. According to one aspect, a method for determining tissue anisotropy comprises: applying, to a tissue sample, a first force having a direction and having a coronal plane normal to the direction of the force, the first force having an oval or other profile with long and short axes within the coronal plane, the long axis being oriented in a first direction within the coronal plane, and measuring a first displacement of the tissue; applying, to the tissue sample, a second force, and measuring a second displacement of the tissue; and calculating a tissue elasticity anisotropy based on the measured first and second displacements. Furthermore, by applying the first and second forces multiple times, tissue viscosity, elasticity, or other anisotropy may be calculated from the multiple displacement measurements. |
| FILED | Monday, May 15, 2017 |
| APPL NO | 16/301085 |
| ART UNIT | 2861 — Printing/Measuring and Testing |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/00 (20130101) A61B 5/0035 (20130101) A61B 5/0053 (20130101) A61B 5/055 (20130101) A61B 5/0057 (20130101) A61B 5/0066 (20130101) Original (OR) Class A61B 5/0077 (20130101) A61B 5/1075 (20130101) A61B 8/08 (20130101) A61B 8/48 (20130101) A61B 8/485 (20130101) Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 15/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 11/00 (20130101) G01N 29/07 (20130101) G01N 29/11 (20130101) G01N 29/043 (20130101) G01N 29/221 (20130101) G01N 2291/015 (20130101) G01N 2291/0289 (20130101) G01N 2291/02475 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/52022 (20130101) G01S 7/52042 (20130101) G01S 15/8915 (20130101) G01S 15/8993 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11445915 | Boppart et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | Stephen A. Boppart (Champaign, Illinois); Roshan I. Dsouza (Champaign, Illinois); Darold R. Spillman, Jr. (Tuscola, Illinois); Paritosh Pande (Richland, Washington); Guillermo L. Monroy (Burbank, Illinois) |
| ABSTRACT | A detector for characterizing at least one of a middle ear fluid and a middle ear biofilm includes a handheld probe outputting near-infrared and visible light, an OCT system to obtain A-scans at a plurality of positions on a tympanic membrane, and a camera to obtain surface sub-images at the plurality of positions. A-scans and surface sub-images are synchronized and the surface sub-images are mosaicked to generate a surface image of the tympanic membrane. Cross-sectional scan images or a thickness map are generated from the synchronized A-scans and segmented to extract a plurality of specified features. The specified features are then classified to characterize at least one of the middle ear fluid and the middle ear biofilm. The detector, including handheld probe with camera, OCT system, and a laptop computer, is sized to fit into a handheld, portable, compact, foam-padded briefcase weighing less than 10 kg. |
| FILED | Tuesday, July 23, 2019 |
| APPL NO | 16/520037 |
| ART UNIT | 2668 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/227 (20130101) A61B 5/0066 (20130101) Original (OR) Class A61B 5/7257 (20130101) Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/02041 (20130101) G01B 9/02091 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/4795 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11445922 | Naima |
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| FUNDED BY |
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| APPLICANT(S) | TERUMO KABUSHIKI KAISHA (Tokyo, Japan) |
| ASSIGNEE(S) | TERUMO KABUSHIKI KAISHA (Tokyo, Japan) |
| INVENTOR(S) | Reza Naima (San Francisco, California) |
| ABSTRACT | In one aspect, a photoplethysmograph system to measure a user's heart rate includes one or more light-emitting diodes (LED) that provide a constantly-on light signal during a measurement period. The one or more light-emitting diodes are in optical contact with an epidermal surface of the user. The one or more light-emitting diodes emit a light signal into the tissue of the user, and wherein the tissue contains a pulsating blood flow. A light-intensity sensor circuit converts the reflected LED light from the tissue into a second signal that is proportional to a reflected light intensity. The second signal includes a voltage or current signal. A computer-processing module calculates the user's beat-to-beat heart rate from the second current signal. |
| FILED | Tuesday, June 26, 2018 |
| APPL NO | 16/019224 |
| ART UNIT | 3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0002 (20130101) A61B 5/0535 (20130101) A61B 5/0537 (20130101) A61B 5/1118 (20130101) A61B 5/02055 (20130101) Original (OR) Class A61B 5/02416 (20130101) A61B 5/6831 (20130101) A61B 5/7207 (20130101) A61B 5/7225 (20130101) A61B 2562/046 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11445933 | Moeller et al. |
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| FUNDED BY |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| ASSIGNEE(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| INVENTOR(S) | Steen Moeller (Minneapolis, Minnesota); Sudhir Ramanna (Minneapolis, Minnesota); Mehmet Akcakaya (Minneapolis, Minnesota) |
| ABSTRACT | Magnetic resonance imaging (“MRI”) data are corrected from corruptions due to physiological changes using a self-navigated phase correction technique. Unlike motion correction techniques, the effects of physiological changes (e.g., breathing and respiration) are corrected by making the MRI data self-consistent relative to an absolute uncorrupted phase reference. This phase correction information can be extracted from the acquisition itself, thereby eliminating the need for a separate navigator scan, and establishing an accelerated acquisition. This absolute reference can be computed in a data segmented space, and the subsequent data can be corrected relative to this absolute reference with low-resolution phases. |
| FILED | Monday, April 27, 2020 |
| APPL NO | 16/858926 |
| ART UNIT | 2852 — Printing/Measuring and Testing |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) Original (OR) Class Measuring Electric Variables; Measuring Magnetic Variables G01R 33/3607 (20130101) G01R 33/4625 (20130101) G01R 33/4826 (20130101) G01R 33/5608 (20130101) G01R 33/5611 (20130101) G01R 33/5616 (20130101) G01R 33/5618 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11445941 | Chen et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Zhongping Chen (Irvine, California); Youmin He (Irvine, California); Joseph Jing (Irvine, California); Yueqiao Qu (Irvine, California); Andrew Emon Heidari (Irvine, California); Jason Chen (Irvine, California) |
| ABSTRACT | Ciliary motion in the upper airway is the primary mechanism by which the body transports foreign particulate out of the respiratory system. The ciliary beating frequency (CBF) is often disrupted with the onset of disease. Current imaging of ciliary motion relies on microscopy and high speed cameras, which cannot be easily adapted to in-vivo imaging. M-mode optical coherence tomography (OCT) imaging is capable of visualization of ciliary activity, but the field of view is limited. The present invention features the development of a spectrally encoded interferometric microscopy (SEIM) system using a phase-resolved Doppler (PRD) algorithm to measure and map the ciliary beating frequency within an on face region. This novel high speed, high resolution system allows for visualization of both temporal and spatial ciliary motion patterns. |
| FILED | Monday, February 03, 2020 |
| APPL NO | 16/780659 |
| ART UNIT | 2488 — Recording and Compression |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/005 (20130101) A61B 1/063 (20130101) A61B 1/00096 (20130101) A61B 1/00149 (20130101) A61B 1/00172 (20130101) A61B 1/00177 (20130101) A61B 1/267 (20130101) A61B 5/0066 (20130101) A61B 5/1128 (20130101) Original (OR) Class Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/02004 (20130101) G01B 9/02041 (20130101) Optical Elements, Systems, or Apparatus G02B 21/0028 (20130101) G02B 21/0048 (20130101) G02B 21/0056 (20130101) G02B 21/365 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11445946 | Cui et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Xinyan Cui (Wexford, Pennsylvania); Ian Mitchell Taylor (Pittsburgh, Pennsylvania) |
| ABSTRACT | Disclosed herein is a method of determining dopamine concentration at a target location in neural tissue. In several embodiments, the method comprises measuring current level in response to square wave voltammetry with a coated electrode of a neural probe implanted at the target location, wherein the coated electrode comprises a coating of poly 3,4 ethylene dioxythiophene (PEDOT) doped with negatively charged carbon nanotubes (CNT), and comparing the measured current level to a control current level to determine the dopamine concentration at the target location. |
| FILED | Wednesday, November 06, 2019 |
| APPL NO | 16/676359 |
| ART UNIT | 1795 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4064 (20130101) A61B 5/14546 (20130101) Original (OR) Class Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/308 (20130101) G01N 27/3277 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11445950 | Kay et al. |
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| FUNDED BY |
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| APPLICANT(S) | The George Washington University (Washington, District of Columbia) |
| ASSIGNEE(S) | The George Washington University (Washington, District of Columbia) |
| INVENTOR(S) | Matthew Kay (Kensington, Maryland); Angel Moreno (Silver Spring, Maryland); Rafael Jaimes (Riverdale, Maryland) |
| ABSTRACT | The invention provides for a system for in vivo real time measurement of NADH recovery kinetics, comprising: 1) a specific pulse sequence to non-destructively, yet effectively, photobleach NADH for measurement of NADH recovery kinetics; 2) illumination light parameters to acquire NADH fluorescence before and after photobleaching, without causing fluorescence bleaching artifacts, for measurement of NADH recovery kinetics; and 3) configurations for devices capable of photobleaching NADH by at least 10% within tissues for effective measurement of NADH recovery kinetics in tissues within a living subject or excised tissues and organs. |
| FILED | Tuesday, February 26, 2019 |
| APPL NO | 16/285920 |
| ART UNIT | 3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/043 (20130101) A61B 1/0684 (20130101) A61B 5/0075 (20130101) A61B 5/0084 (20130101) A61B 5/1459 (20130101) A61B 5/1486 (20130101) Original (OR) Class A61B 5/4866 (20130101) A61B 5/6852 (20130101) A61B 2017/00057 (20130101) A61B 2018/00351 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 7/00 (20130101) A61F 2007/0056 (20130101) A61F 2007/126 (20130101) Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 1/429 (20130101) G01J 1/4257 (20130101) G01J 2001/4247 (20130101) G01J 2001/4252 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11445997 | Avula et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF UTAH RESEARCH FOUNDATION (Salt Lake City, Utah); Sentiomed, Inc. (Salt Lake City, Utah) |
| ASSIGNEE(S) | UNIVERSITY OF UTAH RESEARCH FOUNDATION (Salt Lake City, Utah); SENTIOMED, INC. (Salt Lake City, Utah) |
| INVENTOR(S) | Mahender nath Avula (South Jordan, Utah); Douglas A. Christensen (Salt Lake City, Utah); Navid Farhoudi (Salt Lake City, Utah); Stan Kanarowski (Park City, Utah); Julia Koerner (Salt Lake City, Utah); Jules John Magda (Salt Lake City, Utah); Rami Sami Marrouche (Salt Lake City, Utah); Christopher F. Reiche (Salt Lake City, Utah); Florian Solzbacher (Salt Lake City, Utah); Michael David Sorenson (Salt Lake City, Utah) |
| ABSTRACT | Systems and methods for accurately measuring changes in biomarker sensitive hydrogel volume and shape due to exposure to various biomarkers include a system for identifying one or more dimensional changes in a biomarker sensitive hydrogel positioned within an in vivo environment. The system includes a biomarker sensitive hydrogel positioned within an in vivo environment and configured to dimensionally change in response to interaction with predefined biomarkers. The system additionally includes an ultrasound transducer for locating and identifying one or more characteristics of the biomarker sensitive hydrogel and a computer system in electrical communication with the ultrasound transducer. The computer system is configured to receive characteristics of the biomarker sensitive hydrogel from the ultrasound transducer and determine dimensional changes of the biomarker sensitive hydrogel based on the received characteristics. |
| FILED | Friday, September 01, 2017 |
| APPL NO | 16/330048 |
| ART UNIT | 3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/12 (20130101) A61B 8/481 (20130101) A61B 8/0841 (20130101) Original (OR) Class A61B 90/39 (20160201) A61B 2090/3929 (20160201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11446133 | Papas |
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| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
| ASSIGNEE(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
| INVENTOR(S) | Klearchos K. Papas (Tucson, Arizona) |
| ABSTRACT | Systems featuring two or more encapsulation devices stacked together. The encapsulation devices house cells, such as but not limited to islet cells or stem cell derived beta cells or the like. e.g., for regulating blood glucose, or other cells or spheroids that can produce and release a therapeutic agent that is useful in the body, etc. The system may feature oxygen delivery, or in some cases no exogenous oxygen is delivered and vascularization of the device can help provide oxygen and other needed nutrient to the cells. The system of the present invention may be used in conjunction with other therapies such as an artificial pancreas. Stacking the devices with blood vessel formation around and in between them may allow for a decrease in the footprint that would be needed for implantation. |
| FILED | Friday, November 03, 2017 |
| APPL NO | 16/347388 |
| ART UNIT | 1615 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/022 (20130101) Original (OR) Class A61F 2220/0075 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/52 (20130101) A61L 27/54 (20130101) A61L 27/225 (20130101) A61L 27/227 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11446137 | Rosenblatt et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| INVENTOR(S) | Mark Rosenblatt (Chicago, Illinois); Charles Yu (Urbana, Illinois) |
| ABSTRACT | Described herein are flexible keratoprosthesis devices and uses thereof. The keratoprosthesis devices (100) can include an anchor body (110) and a plurality of flexible haptics (120), wherein the plurality of flexible haptics can be attached to and can be capable of extending radially from the anchor body. The flexible keratoprosthesis devices can be implanted into the eye via a minimally invasive technique. |
| FILED | Friday, April 27, 2018 |
| APPL NO | 16/608263 |
| ART UNIT | 3774 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/15 (20150401) A61F 2/142 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11446238 | Rangaramanujam et al. |
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| FUNDED BY |
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| APPLICANT(S) | Wayne State University (Detroit, Michigan); The United States of America, as represented by the Secretary, Department of Health and Human Resources (Bethesda, Maryland) |
| ASSIGNEE(S) | Wayne State University (Detroit, Michigan); The United States of America, as Represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Kannan Rangaramanujam (Detroit, Michigan); Sujatha Kannan (Detroit, Michigan); Roberto Romero (Grosse Point, Michigan); Raghavendra Navath (Somerset, New Jersey); Anupa Menjoge (New Hyde Park, New York) |
| ABSTRACT | Injectable hydrogels in the form of crosslinked nano beads or particle in the size range 5 nm to 10 μm, comprising PAMAM dendrimer with asymmetrical peripheral end groups such that one of the terminal groups is involved in formation of hydrogel and the other in involved in the conjugation of drugs or imaging agents are formed by reaction of the PAMAM dendrimer with asymmetrical end groups with linear, branched, hyperbranched or star shaped polymers with functionalized terminal groups. The PAMAM dendrimer with asymmetrical terminal groups consists of a Generation 2 and above PAMAM dendrimer with symmetrical end groups modified using the amino acids or their modified forms. The gel is formed as small crosslinked particles in the size range 25 nm to 10 μm and is suitable for injectable delivery of hydrogel or ocular delivery for the purpose of therapeutic treatment and imaging. |
| FILED | Tuesday, September 27, 2016 |
| APPL NO | 15/277877 |
| ART UNIT | 1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) Original (OR) Class A61K 9/0051 (20130101) A61K 31/43 (20130101) A61K 47/595 (20170801) A61K 47/6903 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) A61P 31/00 (20180101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 73/028 (20130101) Compositions of Macromolecular Compounds C08L 79/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11446239 | Ma et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The Children's Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts); THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| INVENTOR(S) | Minglin Ma (Ithaca, New York); Daniel G. Anderson (Framingham, Massachusetts); Robert S. Langer (Newton, Massachusetts); Omid Veiseh (Bellaire, Texas); Joshua Charles Doloff (Quincy, Massachusetts); Delai Chen (Woburn, Massachusetts); Christian J. Kastrup (Bowen Island, Canada); Arturo Jose Vegas (Belmont, Massachusetts) |
| ABSTRACT | Biomedical devices for implantation with decreased pericapsular fibrotic overgrowth are disclosed. The device includes biocompatible materials and has specific characteristics that allow the device to elicit less of a fibrotic reaction after implantation than the same device lacking one or more of these characteristic that are present on the device. Biocompatible hydrogel capsules encapsulating mammalian cells having a diameter of greater than 1 mm, and optionally a cell free core, are disclosed which have reduced fibrotic overgrowth after implantation in a subject. Methods of treating a disease in a subject are also disclosed that involve administering a therapeutically effective amount of the disclosed encapsulated cells to the subject. |
| FILED | Thursday, September 17, 2020 |
| APPL NO | 17/024148 |
| ART UNIT | 1615 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0024 (20130101) Original (OR) Class A61K 9/4833 (20130101) A61K 9/4866 (20130101) A61K 9/5036 (20130101) A61K 9/5078 (20130101) A61K 9/5089 (20130101) A61K 35/39 (20130101) A61K 45/06 (20130101) A61K 2035/126 (20130101) A61K 2035/128 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/046 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11446264 | Sacktor et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (Albany, New York); UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida) |
| ASSIGNEE(S) | THE RESEARCH FOUNDATION FOR THE STATE UNIVERISTY OF NEW YORK (Albany, New York); UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida) |
| INVENTOR(S) | Todd Sacktor (Brooklyn, New York); Mildred Acevedo-Duncan (Plant City, Florida) |
| ABSTRACT | Provided is a method of inhibiting protein kinase C zeta/protein kinase M zeta, including contacting a sample containing an isoform of protein kinase C zeta with a compound of formula: referred to as 1-naphthol-3,6,8-trisulphonic acid, or a pharmaceutically acceptable salt thereof. In some embodiments, contacting the sample with the compound does not inhibit protein kinase C iota/lambda. In a specific example, the sample includes neural tissue, the isoform of protein kinase C zeta is protein kinase M zeta, and inhibiting includes reducing kinase activity and further includes diminishing long-term potentiation. In some embodiment, the method includes inhibiting glucose transport. Also provided is a method of affecting memory, including administering the compounds to a mammalian organism. |
| FILED | Monday, October 15, 2018 |
| APPL NO | 16/755423 |
| ART UNIT | 1629 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1605 (20130101) A61K 31/185 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) A61P 25/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11446279 | Murthy et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Niren Murthy (Berkeley, California); Corinne Sadlowski (Berkeley, California); Bora Park (Berkeley, California) |
| ABSTRACT | Aspects of the present disclosure include antibacterial aromatic sulfonyl fluoride agents. The subject aromatic sulfonyl fluoride agents have a pharmacophore that can provide for potent antibacterial activity. The subject agents are compounds including an aromatic group substituted with a sulfonyl fluoride warhead group and an electron withdrawing group. The subject agents find use in a variety of antibiotic applications. In some cases, the subject agents find use in methods of treating bacterial infections in a subject. Also provided are pharmaceutical compositions and kits that find use in practicing the subject methods. |
| FILED | Wednesday, June 27, 2018 |
| APPL NO | 16/618952 |
| ART UNIT | 1626 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/10 (20130101) A61K 31/381 (20130101) Original (OR) Class A61K 31/4178 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Heterocyclic Compounds C07D 333/44 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11446299 | Hernandez-O'Farrill et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PUERTO RICO (San Juan, Puerto Rico) |
| ASSIGNEE(S) | UNIVERSITY OF PUERTO RICO (San Juan, Puerto Rico) |
| INVENTOR(S) | Eliud Hernandez-O'Farrill (San Juan, Puerto Rico); Cornelis P. Vlaar (San Juan, Puerto Rico); Suranganie Dharmawardhane Flanagan (San Juan, Puerto Rico); Linette Castillo-Pichardo (San Juan, Puerto Rico) |
| ABSTRACT | A series of novel EHop-016 derivatives is presented herein via designing and synthesizing compounds that mimics its more favorable “U-shaped” conformation that appears to be critical for inhibitory activity against Rac. Based on modeling studies on EHop-016, compounds with a more rigid structural conformation can mimic this “U-shaped” conformation and would improve the anti-migration activity against metastatic cells. Compounds are disclosed that inhibit RhoGTPases that are useful for inhibiting hyperprofilerative and neoplastic diseases, for instance compounds of formula Specifically, the compounds inhibit the GTPases Rac and Cdc42 that are overactive or overexpressed in signaling pathways in cancer and metastasis. Methods for treatment of cancer and hyperproliferative diseases are disclosed. |
| FILED | Wednesday, July 08, 2020 |
| APPL NO | 16/923853 |
| ART UNIT | 1626 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/506 (20130101) Original (OR) Class A61K 31/5377 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 401/14 (20130101) C07D 403/12 (20130101) C07D 403/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11446302 | Robichaux et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Jacqulyne Robichaux (Houston, Texas); Monique Nilsson (Houston, Texas); John V. Heymach (Houston, Texas) |
| ABSTRACT | The present disclosure provides methods of treating cancer in a patient determined to have an EGFR and/or HER2 exon 20 mutation, such as an insertion mutation, by administering a third-generation tyrosine kinase inhibitor, such as poziotinib or afatinib. |
| FILED | Friday, November 17, 2017 |
| APPL NO | 16/461992 |
| ART UNIT | 1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/517 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11446308 | Zuo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | St. Jude Children's Research Hospital (Memphis, Tennessee) |
| ASSIGNEE(S) | St Jude Children's Research Hospital (, None) |
| INVENTOR(S) | Jian Zuo (Memphis, Tennessee); Tai Teitz (Memphis, Tennessee); Jie Fang (Memphis, Tennessee); Asli Goktug (Memphis, Tennessee); Taosheng Chen (Germantown, Tennessee); Jaeki Min (Memphis, Tennessee); R. Kiplin Guy (Memphis, Tennessee) |
| ABSTRACT | In one aspect, pharmaceutical compositions comprising a CDK2 inhibitor and one or more of at least one agent known to treat a hearing impairment and at least one agent known to prevent a hearing impairment, and methods of treating and/or preventing hearing impairments or disorders using the compositions are disclosed. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| FILED | Monday, December 09, 2019 |
| APPL NO | 16/707991 |
| ART UNIT | 1628 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/52 (20130101) A61K 31/55 (20130101) Original (OR) Class A61K 31/404 (20130101) A61K 31/454 (20130101) A61K 31/506 (20130101) A61K 31/519 (20130101) A61K 31/4015 (20130101) A61K 31/4155 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/16 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11446309 | Bradner et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | James E. Bradner (Weston, Massachusetts); Michael R. McKeown (Brookline, Massachusetts); Margaret A. Shipp (Wellesley, Massachusetts); Bjoern Chapuy (Boston, Massachusetts); Kwok-kin Wong (Arlington, Massachusetts); Zhao Chen (Sharon, Massachusetts) |
| ABSTRACT | The present invention provides methods for treating cancer using combinations of bromodomain and extra-terminal (BET) protein inhibitors and certain chemotherapeutic drugs. |
| FILED | Friday, November 07, 2014 |
| APPL NO | 15/034922 |
| ART UNIT | 1627 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/404 (20130101) A61K 31/453 (20130101) A61K 31/551 (20130101) Original (OR) Class A61K 31/5377 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 487/04 (20130101) C07D 495/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11446331 | Frank et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts); Children's Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | The Brigham and Women's Hospital, Inc. (Boston, Massachusetts); Children's Medical Center Corporation (Boston, Massachusetts); The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | Markus H. Frank (Cambridge, Massachusetts); Natasha Y. Frank (Cambridge, Massachusetts); Dennis P. Orgill (Belmont, Massachusetts); George F. Murphy (Boston, Massachusetts) |
| ABSTRACT | The present invention is directed to wound healing scaffolds cografted with a population of stem cells, wherein the population of stem cells are ABCB5+ stem cells. The scaffolds are, for instance, collagen glycosaminoglycan scaffolds. |
| FILED | Friday, May 09, 2014 |
| APPL NO | 14/890251 |
| ART UNIT | 1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) Original (OR) Class A61K 38/00 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/26 (20130101) A61L 27/26 (20130101) A61L 27/26 (20130101) A61L 27/26 (20130101) A61L 27/54 (20130101) A61L 27/56 (20130101) A61L 27/3834 (20130101) A61L 27/3886 (20130101) A61L 2430/16 (20130101) A61L 2430/34 (20130101) A61L 2430/40 (20130101) Compositions of Macromolecular Compounds C08L 5/08 (20130101) C08L 5/10 (20130101) C08L 89/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/063 (20130101) C12N 5/0668 (20130101) C12N 2533/30 (20130101) C12N 2533/54 (20130101) C12N 2533/70 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11446352 | Chadli |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Augusta University Research Institute, Inc. (Augusta, Georgia) |
| ASSIGNEE(S) | AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC. (Augusta, Georgia) |
| INVENTOR(S) | Ahmed Chadli (Evan, Georgia) |
| ABSTRACT | It has been discovered that the cyclic peptide EnnA inactivates the Hsp90 chaperone pathway, but without activating an extensive heat shock response and overexpression of anti-apoptotic proteins. Mechanistically distinct, EnnA inhibits Hsp90 and destabilize PDL-1 and IDO, two major immune checkpoints mediating tumor-induced immune suppression. The provided herein show that EnnA profoundly modulates the cytokine signature of cancer cells and promotes a cytokine profile that favors an immune attack on tumor cells. This translates into highly efficacious anti-tumor activity in vivo, which, when combined with a single dose of chemotherapy, completely reduced the tumor burden in experimental animals and instilled highly efficient immune memory against the primary tumor. |
| FILED | Monday, November 05, 2018 |
| APPL NO | 16/180203 |
| ART UNIT | 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/664 (20130101) A61K 38/12 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11446356 | Cochran et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Jennifer R. Cochran (Stanford, California); Richard H. Kimura (Menlo Park, California); Aron M. Levin (Menlo Park, California) |
| ABSTRACT | Engineered peptides that bind with high affinity (low equilibrium dissociation constant (Kd)) to the cell surface receptors of fibronectin (α5β1) or vitronectin (αvβ3 and αvβ5 integrins) are disclosed as useful as imaging tissue. These peptides are based on a molecular scaffold into which a subsequence containing the RGD integrin-binding motif has been inserted. The subsequence (RGD mimic) comprises about 9-13 amino acids, and the RGD contained within the subsequence can be flanked by a variety of amino acids, the sequence of which was determined by sequential rounds of selection (in vitro evolution). The molecular scaffold is preferably based on a knottin, e.g., EETI (Trypsin inhibitor 2 (Trypsin inhibitor II) (EETI-II) [Ecballium elaterium (Jumping cucumber)], AgRP (Agouti-related protein), and Agatoxin IVB, which peptides have a rigidly defined three-dimensional conformation. It is demonstrated that EETI tolerates mutations in other loops and that the present peptides may be used as imaging agents. |
| FILED | Friday, February 28, 2020 |
| APPL NO | 16/805058 |
| ART UNIT | 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/06 (20130101) A61K 38/08 (20130101) A61K 38/1709 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 49/0056 (20130101) A61K 51/082 (20130101) Peptides C07K 14/47 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57492 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11446378 | Vermeer |
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| FUNDED BY |
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| APPLICANT(S) | SANFORD HEALTH (Sioux Falls, South Dakota) |
| ASSIGNEE(S) | Sanford Health (Sioux Falls, South Dakota) |
| INVENTOR(S) | Paola Vermeer (Sioux Falls, South Dakota) |
| ABSTRACT | Disclosed herein are compositions and methods for tumor treatment involving administering to a subject having a tumor with an amount effective to limit tumor growth or metastasis of an ephrin B1 inhibitor, or a pharmaceutically acceptable salt thereof; and/or an inhibitor of tumor exosomal release, or a pharmaceutically acceptable salt thereof. |
| FILED | Friday, February 23, 2018 |
| APPL NO | 16/482048 |
| ART UNIT | 1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/506 (20130101) A61K 39/39558 (20130101) Original (OR) Class Peptides C07K 16/28 (20130101) C07K 16/40 (20130101) C07K 2317/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1138 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5011 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11446390 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| INVENTOR(S) | Andrew Wang (Durham, North Carolina); Yuanzeng Min (Nanjing, China PRC); Zach Rodgers (Kent, Ohio) |
| ABSTRACT | Disclosed herein are antigen-capturing nanoparticles. Specifically, the subject matter contained herein pertains to novel nanoparticles that can capture a multitude of tumor antigens that are released from tumor cells. Also, provided herein are methods for preparing the antigen-capturing nanoparticles and methods for the treatment of disease in a subject comprising administering the antigen-capturing nanoparticles. |
| FILED | Thursday, November 17, 2016 |
| APPL NO | 15/777075 |
| ART UNIT | 1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/19 (20130101) A61K 9/5123 (20130101) A61K 9/5146 (20130101) A61K 9/5153 (20130101) A61K 9/5169 (20130101) A61K 39/39 (20130101) A61K 47/34 (20130101) A61K 47/42 (20130101) A61K 47/6937 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11446391 | Tsourkas et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Andrew Tsourkas (Bryn Mawr, Pennsylvania); Jayesh Thawani (Houston, Texas); Ahmad Amirshaghaghi (Philadelphia, Pennsylvania); Lesan Yan (Philadelphia, Pennsylvania); Zhiliang Cheng (Newtown, Pennsylvania) |
| ABSTRACT | The invention relates to amphiphilic dye-coated inorganic nanoparticle clusters and uses thereof. Specifically, the invention relates to cyanine and/or cyclic tetrapyrrole dye-coated metallic nanoparticle clusters for use in medical imaging and treatments. |
| FILED | Thursday, July 05, 2018 |
| APPL NO | 16/628739 |
| ART UNIT | 1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/107 (20130101) A61K 41/0071 (20130101) A61K 47/6923 (20170801) A61K 47/6937 (20170801) Original (OR) Class A61K 49/0034 (20130101) A61K 49/0093 (20130101) A61K 49/1833 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11446392 | Kent et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio); Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Ohio State Innovation Foundation (Columbus, Ohio); Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | K. Craig Kent (Columbus, Ohio); Shaoqin Gong (Middleton, Wisconsin); Lianwang Guo (Columbus, Ohio); Bowen Wang (Columbus, Ohio); Guojun Chen (Madison, Wisconsin); Go Urabe (Columbus, Ohio) |
| ABSTRACT | The present disclosure relates to unimolecular core-shell nanoparticle, nanoclusters thereof, and platelet biomimetic nanoclusters thereof. The disclosed compositions are useful for treating a subject with a disease or condition, such as a cardiovascular disease. In a further aspect, the cardiovascular disease can be a vascular stenosis or restenosis. Also described herein are methods of making and using the unimolecular core-shell nanoparticle, nanoclusters thereof, and platelet biomimetic nanoclusters thereof. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure. |
| FILED | Thursday, May 23, 2019 |
| APPL NO | 17/057415 |
| ART UNIT | 1613 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5153 (20130101) A61K 45/06 (20130101) A61K 47/6937 (20170801) Original (OR) Class Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11446396 | Mendell et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NATIONWIDE CHILDREN'S HOSPITAL, INC. (Columbus, Ohio) |
| ASSIGNEE(S) | NATIONWIDE CHILDREN'S HOSPITAL, INC. (Columbus, Ohio) |
| INVENTOR(S) | Jerry R. Mendell (Columbus, Ohio); Louis Chicoine (Westerville, Ohio); Louise Rodino-Klapac (Groveport, Ohio); Kelly Reed Clark (Columbus, Ohio); Thomas J. Preston (Groveport, Ohio) |
| ABSTRACT | The present invention relates to recombinant adeno-associated virus (rAAV) delivery of an alpha-sarcoglycan gene. The invention provides rAAV products and methods of using the rAAV in the treatment of limb girdle muscular dystrophies such as LGMD2D. |
| FILED | Wednesday, September 19, 2018 |
| APPL NO | 16/135222 |
| ART UNIT | 1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) A61K 48/005 (20130101) A61K 48/0058 (20130101) Original (OR) Class A61K 48/0066 (20130101) A61K 48/0075 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/3603 (20140204) A61M 5/1408 (20130101) Peptides C07K 14/4707 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11446497 | Bhadra et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| INVENTOR(S) | Niloy Bhadra (Richmond Heights, Ohio); Thomas Eggers (Cleveland Heights, Ohio); Kevin L. Kilgore (Avon Lake, Ohio) |
| ABSTRACT | The occurrence of negative consequences (e.g., painful tetanic muscle contractions) associated with the onset response associated with kilohertz frequency alternating current (KHFAC) electrical nerve block can be reduced by fatiguing a muscle (through depletion of neurotransmitters at the neuromuscular junction, within a second) before applying KHFAC electrical nerve block to a nerve associated with the muscle. The nerve can first be stimulated with an electrical signal for a first time period to fatigue the muscle. Then, immediately following the first time period (while the muscle is fatigued), a blocking electrical signal (e.g., a kilohertz frequency alternating current waveform) can be applied to the nerve to create a localized nerve block. |
| FILED | Monday, June 22, 2020 |
| APPL NO | 16/907916 |
| ART UNIT | 3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0556 (20130101) A61N 1/36003 (20130101) A61N 1/36067 (20130101) Original (OR) Class A61N 1/36121 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11446506 | Narayan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); TOPERA, INC. (Menlo Park, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California); The United States of America as Represented by the Department of Veterans Affairs (Washington, District of Columbia); Topera, Inc. (Menlo Park, California) |
| INVENTOR(S) | Sanjiv M. Narayan (Palo Alto, California); Carey Robert Briggs (La Jolla, California); Ruchir Sehra (Scottsdale, Arizona) |
| ABSTRACT | An example system and method associated with identifying and treating a source of a heart rhythm disorder are disclosed. In accordance therewith, a spatial element associated with a region of the heart is selected. Progressive rotational activations or progressive focal activations are determined in relation to the selected spatial element over a period of time. The selecting and determining are repeated over multiple periods of time. A source parameter of rotation activations or focal activations is determined, wherein the source parameter indicates consistency of successive rotational activations or focal activations in relation to a portion of the region of the heart. The determining of a source parameter is repeated for multiple regions of the heart. Thereafter, representation of the source parameter is displayed for each of the multiple regions of the heart to identify a shape representing the source of the heart rhythm disorder. |
| FILED | Thursday, September 05, 2019 |
| APPL NO | 16/562099 |
| ART UNIT | 3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0006 (20130101) A61B 5/287 (20210101) A61B 5/02405 (20130101) A61B 2018/00577 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 2230/06 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/365 (20130101) A61N 1/378 (20130101) A61N 1/3622 (20130101) A61N 1/3712 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11446516 | Greene et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Mark Greene (Penn Valley, Pennsylvania); Hongtao Zhang (Paoli, Pennsylvania); Hiromichi Tsuchiya (Philadelphia, Pennsylvania); Yasuhiro Nagai (Philadelphia, Pennsylvania); Lian Lam (Philadelphia, Pennsylvania); Aaron Runkle (Philadelphia, Pennsylvania); Jeffrey Drebin (Bryn Mawr, Pennsylvania); Mei Qing Ji (Voorhees, New Jersey) |
| ABSTRACT | Disclosed herein are methods of increasing response to radiation therapy in subjects afflicted with cancer. In some embodiments, the method comprises reducing the ability of an immune suppressor cell (e.g., MDSC) to migrate to the microenvironment of the cancer. In some embodiments, the method further comprises suppressing the migration of the immune suppressor cell to a non-malignant cell and/or suppressing the malignant transformation of the non-malignant cells. |
| FILED | Wednesday, July 14, 2021 |
| APPL NO | 17/375459 |
| ART UNIT | 3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/10 (20130101) Original (OR) Class A61N 2005/1098 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11446523 | Bar-Zion et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| INVENTOR(S) | Avinoam D. Bar-Zion (Pasadena, California); Atousa Nourmahnad (Villanova, Pennsylvania); David Maresca (Pasadena, California); Mikhail Shapiro (Pasadena, California) |
| ABSTRACT | The system and process of therapeutic and effective cavitation by using ultrasound to collapse gas vesicles as well as cavitate the bubbles produced from the collapsed gas vesicles. Therapeutic effect includes, but is not limited to lysing cells by cavitation. The cells expressing the gas vesicles can optionally be used as delivery cells to preform tasks such as transporting the gas vesicles into deep tissue areas, releasing compounds at the cavitation site, and more. The gas vesicles can optionally be modified to facilitate getting the bubbles near the cavitation targets by functionalizing the gas vesicles. |
| FILED | Sunday, March 29, 2020 |
| APPL NO | 16/833637 |
| ART UNIT | 3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 7/00 (20130101) Original (OR) Class A61N 2007/0004 (20130101) A61N 2007/0039 (20130101) A61N 2007/0052 (20130101) A61N 2007/0082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447445 | Imig et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Medical College of Wisconsin, Inc. (Milwaukee, Wisconsin); Johann Wolfgang Goethe-Universitat Frankfurt (Frankfurt am Main, Germany) |
| ASSIGNEE(S) | The Medical College of Wisconsin, Inc. (Milwaukee, Wisconsin); Johann Wolfgang Goethe-Universität Frankfurt (Frankfurt am Main, Germany) |
| INVENTOR(S) | John David Imig (Pewaukee, Wisconsin); Md. Abdul Hye Khan (Milwaukee, Wisconsin); Eugen Proschak (Frankfurt am Main, Germany); Rene Blocher (Frankfurt am Main, Germany) |
| ABSTRACT | N-benzylbenzamides that act as dual soluble epoxide hydrolase (sEH)/peroxisome proliferator-activated receptor γ (PPARγ) modulators and are useful as medications in the treatment of Metabolic Syndrome (MetS) cluster diseases, including diabetes. Methods of making and using the same are further provided. |
| FILED | Wednesday, December 23, 2020 |
| APPL NO | 17/132310 |
| ART UNIT | 1626 — Organic Chemistry |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/062 (20130101) A61B 5/6852 (20130101) A61B 18/1492 (20130101) A61B 2018/00029 (20130101) A61B 2018/00577 (20130101) A61B 2034/2051 (20160201) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 25/0012 (20130101) A61M 25/0127 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) Acyclic or Carbocyclic Compounds C07C 233/65 (20130101) C07C 233/66 (20130101) Original (OR) Class C07C 233/73 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447452 | Duerfeldt et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of the University of Oklahoma (Norman, Oklahoma) |
| ASSIGNEE(S) | The Board of Regents of the University of Oklahoma (Norman, Oklahoma) |
| INVENTOR(S) | Adam Duerfeldt (Norman, Oklahoma); Jian-xing Ma (Edmond, Oklahoma); Xiaozheng Dou (Norman, Oklahoma); Dinesh Nath (Meerut, India); Young-Hwa Shin (Oklahoma City, Oklahoma) |
| ABSTRACT | Benzyl derivative compounds having peroxisome proliferator-activated receptor α (PPARα) agonistic activity, compositions containing such compounds, and methods of their use in enhancing PPARα activity for treating diseases and/or conditions involving inflammation and/or angiogenesis, particularly ocular diseases and/or conditions such as but not limited to retinal inflammation, retinal neovascularization, retinal vascular leakage, retinopathy of prematurity, diabetic retinopathy, age-related macular degeneration, and diabetic macular edema are disclosed. |
| FILED | Friday, March 15, 2019 |
| APPL NO | 16/981483 |
| ART UNIT | 1625 — Organic Chemistry |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 69/734 (20130101) Heterocyclic Compounds C07D 215/52 (20130101) Original (OR) Class C07D 263/32 (20130101) C07D 277/56 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447453 | Cosford et al. |
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| FUNDED BY |
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| APPLICANT(S) | Sanford Burnham Prebys Medical Discovery Institute (La Jolla, California) |
| ASSIGNEE(S) | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE (La Jolla, California) |
| INVENTOR(S) | Nicholas David Peter Cosford (San Diego, California); Dhanya Raveendra-Panickar (San Diego, California); Douglas J. Sheffler (San Diego, California); John Howard Hutchinson (San Diego, California); Reto Andreas Gadient (San Diego, California) |
| ABSTRACT | Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor negative allosteric modulators (NAMs), compositions comprising the compounds, and methods of using the compounds and compositions. |
| FILED | Thursday, March 12, 2020 |
| APPL NO | 16/817209 |
| ART UNIT | 1628 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/426 (20130101) A61K 31/427 (20130101) A61K 31/433 (20130101) A61K 31/505 (20130101) A61K 31/506 (20130101) A61K 31/4196 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) Heterocyclic Compounds C07D 217/06 (20130101) C07D 231/12 (20130101) C07D 233/54 (20130101) C07D 233/64 (20130101) C07D 239/26 (20130101) C07D 243/12 (20130101) C07D 243/14 (20130101) Original (OR) Class C07D 249/08 (20130101) C07D 261/08 (20130101) C07D 263/32 (20130101) C07D 271/06 (20130101) C07D 275/02 (20130101) C07D 277/20 (20130101) C07D 277/26 (20130101) C07D 277/30 (20130101) C07D 285/08 (20130101) C07D 307/38 (20130101) C07D 333/24 (20130101) C07D 401/04 (20130101) C07D 401/10 (20130101) C07D 401/12 (20130101) C07D 401/14 (20130101) C07D 403/10 (20130101) C07D 403/12 (20130101) C07D 405/04 (20130101) C07D 405/10 (20130101) C07D 409/02 (20130101) C07D 409/04 (20130101) C07D 409/14 (20130101) C07D 413/04 (20130101) C07D 413/14 (20130101) C07D 417/04 (20130101) C07D 417/10 (20130101) C07D 417/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447461 | Thatcher et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | Gregory R. Thatcher (Urbana, Illinois); Rui Xiong (Urbana, Illinois); Jiong Zhao (Urbana, Illinois); Debra A. Tonetti (Urbana, Illinois) |
| ABSTRACT | This invention is benzothiophene-based estrogen receptor downregulators and their compositions and uses to treat estrogen-related medical disorders. |
| FILED | Monday, October 19, 2020 |
| APPL NO | 17/074550 |
| ART UNIT | 1626 — Organic Chemistry |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/10 (20180101) A61P 35/00 (20180101) Heterocyclic Compounds C07D 333/64 (20130101) Original (OR) Class C07D 409/06 (20130101) C07D 409/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447482 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | KUDA Therapeutics, Inc. (Salt Lake City, Utah) |
| ASSIGNEE(S) | KUDA THERAPEUTICS, INC. (Salt Lake City, Utah) |
| INVENTOR(S) | Xiaohui Liu (Salt Lake City, Utah); Mei Yee Koh (Salt Lake City, Utah) |
| ABSTRACT | Novel substituted imidazopyridine and oxazolopyridine compounds that are useful as inhibitors of HIF-2α and inducers of ferroptosis through perturbations in iron metabolism, synthetic methods for making said compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds and compositions to treat disorders associated with dysfunction of HIF-2α or iron metabolism. |
| FILED | Friday, February 14, 2020 |
| APPL NO | 16/791148 |
| ART UNIT | 1625 — Organic Chemistry |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 417/12 (20130101) Original (OR) Class C07D 471/04 (20130101) C07D 487/04 (20130101) C07D 498/04 (20130101) C07D 513/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447495 | Arnold et al. |
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| FUNDED BY |
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| APPLICANT(S) | UWM Research Foundation, Inc. (Milwaukee, Wisconsin); The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | UWM Research Foundation, Inc. (Milwaukee, Wisconsin); The Trustees of Columbia University in the City of New York (New York, New York) |
| INVENTOR(S) | Alexander E. Arnold (Milwaukee, Wisconsin); Douglas C. Stafford (Stoughton, Wisconsin); James M. Cook (Milwaukee, Wisconsin); Charles W. Emala (Woodcliff Lake, New Jersey); Gloria Forkuo (Milwaukee, Wisconsin); Rajwana Jahan (Milwaukee, Wisconsin); Revathi Kodali (Milwaukee, Wisconsin); Guanguan Li (Milwaukee, Wisconsin); Michael Rajesh Stephen (Milwaukee, Wisconsin) |
| ABSTRACT | Substituted benzo[f]imidazo[1,5-α][1,4]diazepines of formula (I′) target alpha-4 and alpha-5 GABAA receptors for use in the treatment of airway hyperresponsiveness and inflammation in asthma. Compounds selectively partition to the peripheral compartment and have reduced CNS effects. |
| FILED | Wednesday, August 16, 2017 |
| APPL NO | 16/325080 |
| ART UNIT | 1624 — Organic Chemistry |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/06 (20180101) Heterocyclic Compounds C07D 487/04 (20130101) C07D 487/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447502 | Ebright et al. |
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| FUNDED BY |
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| APPLICANT(S) | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (New Brunswick, New Jersey) |
| ASSIGNEE(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | Richard H. Ebright (New Brunswick, New Jersey); Yon W. Ebright (New Brunswick, New Jersey); Chih-Tsung Lin (New Brunswick, New Jersey) |
| ABSTRACT | The invention provides bipartite, dual-targeted inhibitors of bacterial RNA polymerase having the general structural formula (I): X-α-Y (I) wherein X is an moiety that binds to the Rif target of a bacterial RNA polymerase; Y is a moiety that binds to the bridge-helix N-terminus target of a bacterial RNA polymerase; and is a covalent bond or a linker. The invention also provides compositions comprising such compounds, methods of making such compounds, and methods of using said compounds. The invention has applications in control of bacterial gene expression, control of bacterial growth, antibacterial chemistry, and antibacterial therapy. |
| FILED | Thursday, May 23, 2019 |
| APPL NO | 17/058589 |
| ART UNIT | 1625 — Organic Chemistry |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/06 (20180101) Heterocyclic Compounds C07D 498/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447515 | Gin et al. |
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| FUNDED BY |
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| APPLICANT(S) | SLOAN KETTERING INSTITUTE FOR CANCER RESEARCH (New York, New York) |
| ASSIGNEE(S) | SLOAN KETTERING INSTITUTE FOR CANCER RESEARCH (New York, New York) |
| INVENTOR(S) | David Gin (New York, New York); Michelle Adams (Waterville, Ohio); Kai Deng (Guilderland, New York); Philip Livingston (New York, New York); Govindaswami Ragupathi (New York, New York); Eric Chea (Flushing, New York); Alberto Fernandez-Tejada (New York, New York); Lars Ulrik Nordstroem (New York, New York); William Walkowicz (Brooklyn, New York); Jeffrey Gardner (New York, New York); Derek Tan (New York, New York) |
| ABSTRACT | The present invention relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, intermediates thereto, and uses thereof. QS-7 is a potent immuno-adjuvant that is significantly less toxic than QS-21, a related saponin that is currently the favored adjuvant in anticancer and antiviral vaccines. Tedious isolation and purification protocols have hindered the clinical development of QS-7. A novel semi-synthetic method is provided wherein a hydrolyzed prosapogenin mixture is used to synthesize QS-7, QS-21, and related analogs, greatly facilitating access to QS-7 and QS-21 analogs for preclinical and clinical evaluation. |
| FILED | Friday, June 16, 2017 |
| APPL NO | 15/626046 |
| ART UNIT | 1623 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/704 (20130101) A61K 31/7024 (20130101) A61K 39/385 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 13/08 (20130101) C07H 15/24 (20130101) C07H 15/256 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447519 | Purse et al. |
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| FUNDED BY |
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| APPLICANT(S) | San Diego State University Research Foundation (San Diego, California) |
| ASSIGNEE(S) | San Diego State University Research Foundation (San Diego, California) |
| INVENTOR(S) | Byron W. Purse (San Diego, California); Dillon Burns (San Diego, California); Kristine Teppang (San Diego, California); Raymond Lee (San Diego, California); Melissa Lokensgard (San Diego, California) |
| ABSTRACT | Herein reported are new tricyclic cytidine compounds, such as 8-diethylamino-tC (8-DEA-tC), that respond to DNA and/or RNA duplex formation with up to a 20-fold increase in fluorescent quantum yield as compared with the free nucleoside, depending on neighboring bases. This turn-on response to duplex formation is by far the greatest of any reported nucleoside analogue that can participate in Watson-Crick base pairing. Measurements of the quantum yield of 8-DEA-tC mispaired with adenosine and, separately, opposite an abasic site show that there is almost no fluorescence increase without the formation of correct Watson-Crick hydrogen bonds. Kinetic isotope effects from the use of deuterated buffer show that the duplex protects 8-DEA-tC against quenching by excited state proton transfer. DFT calculations provide a rationale for the observed photophysical properties that is dependent on duplex integrity and the electronic structure of the analogue. |
| FILED | Thursday, November 09, 2017 |
| APPL NO | 16/346708 |
| ART UNIT | 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 19/24 (20130101) Original (OR) Class Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) C09K 2211/1018 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/682 (20130101) C12Q 1/686 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/77 (20130101) G01N 2021/7786 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447523 | Szeto et al. |
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| FUNDED BY |
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| APPLICANT(S) | Cornell Research Foundation, Inc. (Ithaca, New York) |
| ASSIGNEE(S) | CORNELL RESEARCH FOUNDATION, INC. (Ithaca, New York) |
| INVENTOR(S) | Hazel H. Szeto (New York, New York); Shaoyi Liu (Palisades Park, New Jersey); Sunghee Cho (Scarsdale, New York) |
| ABSTRACT | The invention provides a method for treating one or more complications of diabetes in a mammal. The method comprises administering to a mammal in need thereof an effective amount of an aromatic-cationic peptide having at least one net positive charge; a minimum of four amino acids; a maximum of about twenty amino acids; a relationship between the minimum number of net positive charges (pm) and the total number of amino acid residues (r) wherein 3 pm is the largest number that is less than or equal to r+1; and a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (pt) wherein 2a is the largest number that is less than or equal to pt+1, except that when a is 1, pt may also be 1. |
| FILED | Thursday, April 02, 2020 |
| APPL NO | 16/838290 |
| ART UNIT | 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/03 (20130101) A61K 38/06 (20130101) A61K 38/07 (20130101) A61K 38/08 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) Peptides C07K 5/101 (20130101) Original (OR) Class C07K 5/1008 (20130101) C07K 5/1016 (20130101) C07K 5/1019 (20130101) C07K 5/1024 (20130101) C07K 14/705 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447541 | Westendorf et al. |
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| FUNDED BY |
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| APPLICANT(S) | AbCellera Biologies Inc. (Vancouver, Canada); The United States of America, as represented by the Secretary, Department of Health and Human Svcs. (Bethesda, Maryland) |
| ASSIGNEE(S) | AbCellera Biologies Inc. (Vancouver, Canada); The United States of America, as represented by the Secretary, Department of Health and Human Svcs. (Bethesda, Maryland) |
| INVENTOR(S) | Kathryn Westendorf (Vancouver, Canada); Stefanie Zentelis (Vancouver, Canada); Krithika Muthuraman (Toronto, Canada); Kevin Jepson (Vancouver, Canada); Ester Falconer (Vancouver, Canada); John Mascola (Bethesda, Maryland); Barney Graham (Bethesda, Maryland); Kizzmekia Corbett (Bethesda, Maryland); Julie Ledgerwood (Bethesda, Maryland); Lingshu Wang (Bethesda, Maryland); Olubukola Abiona (Bethesda, Maryland); Wei Shi (Bethesda, Maryland); Wing-pui Kong (Bethesda, Maryland); Yi Zhang (Bethesda, Maryland); Bryan Edward Jones (San Diego, California); Denisa Foster (San Diego, California); Julian Davies (La Jolla, California); Qing Chai (San Diego, California); Christopher Carl Frye (Bargersville, Indiana); Ganapathy Gopalrathnam (Fishers, Indiana); Jörg Hendle (San Diego, California); John Michael Sauder (Carlsbad, California); Jeffrey Streetman Boyles (Indianapolis, Indiana); Anna Pustilnik (San Diego, California) |
| ABSTRACT | Antibodies that bind SARS-CoV Spike protein, SARS-CoV-2 Spike protein, and methods of using same for treating or preventing conditions associated with SARS or COVID-19 and for detecting SARS-CoV or SARS-CoV-2. |
| FILED | Tuesday, June 22, 2021 |
| APPL NO | 17/354476 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/02 (20130101) A61K 47/26 (20130101) A61K 47/68 (20170801) A61K 47/183 (20130101) A61K 2039/54 (20130101) A61K 2039/545 (20130101) Peptides C07K 16/10 (20130101) Original (OR) Class C07K 2317/76 (20130101) C07K 2317/565 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447563 | Liu |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Bin Liu (San Francisco, California) |
| ABSTRACT | Methods are provided for identifying and selecting antibodies that are internalized into cells via the macropinocytosis pathway. Additionally antibodies that are internalized via this pathway are provided as well as immunoconjugates comprising such antibodies. |
| FILED | Friday, December 13, 2019 |
| APPL NO | 16/714566 |
| ART UNIT | 1639 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) A61K 47/6801 (20170801) A61K 47/6851 (20170801) A61K 47/6889 (20170801) A61K 49/00 (20130101) Peptides C07K 16/005 (20130101) C07K 16/30 (20130101) Original (OR) Class C07K 16/2866 (20130101) C07K 16/3069 (20130101) C07K 2317/10 (20130101) C07K 2317/21 (20130101) C07K 2317/32 (20130101) C07K 2317/73 (20130101) C07K 2317/77 (20130101) C07K 2317/622 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1037 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 40/10 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) G01N 33/6854 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447593 | Gao et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of the University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | The Board of Regents of The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Jinming Gao (Plano, Texas); David Boothman (, None); Kejin Zhou (Dallas, Texas); Xiaonan Huang (Beijing, China PRC); Yiguang Wang (Dallas, Texas) |
| ABSTRACT | Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises wherein R′ is —H or —CH3, wherein R is —NR1R2, wherein R1 and R2 are alkyl groups, wherein R1 and R2 are the same or different, wherein R1 and R2 together have from 5 to 16 carbons, wherein R1 and R2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications. |
| FILED | Tuesday, March 10, 2020 |
| APPL NO | 16/814845 |
| ART UNIT | 1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1075 (20130101) A61K 9/1273 (20130101) A61K 9/5031 (20130101) A61K 31/337 (20130101) A61K 31/352 (20130101) A61K 31/704 (20130101) A61K 47/58 (20170801) A61K 47/62 (20170801) A61K 47/6811 (20170801) A61K 47/6845 (20170801) A61K 47/6907 (20170801) A61K 49/005 (20130101) A61K 49/0032 (20130101) A61K 49/0054 (20130101) A61K 49/0056 (20130101) A61K 49/0082 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 311/92 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 293/005 (20130101) Original (OR) Class C08F 299/024 (20130101) C08F 2438/01 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 81/025 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/582 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447734 | Reiserer et al. |
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| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| INVENTOR(S) | Ronald S. Reiserer (Nashville, Tennessee); Gregory B. Gerken (Nashville, Tennessee); David K. Schaffer (Nashville, Tennessee); John P. Wikswo (Brentwood, Tennessee) |
| ABSTRACT | A continuous automated perfusion culture analysis system (CAPCAS) comprises one or more fluidic systems configured to operate large numbers of biodevices in parallel. Each fluidic system comprises an input reservoir plate for receiving media; a biodevice plate comprising an array of biodevices fluidically coupled to the input reservoir plate, configured such that each biodevice has independent media delivery, fluid removal, stirring, and gas control, and each biodevice is capable of continuously receiving the media from the input reservoir plate; and an output plate fluidically coupled to the biodevice plate for real-time analysis and sampling. The operations of the CAPCAS are automated and computer-controlled wirelessly. The CAPCAS can also be used for abiotic and biotic chemical synthesis processes. |
| FILED | Wednesday, January 19, 2022 |
| APPL NO | 17/578966 |
| ART UNIT | 1799 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/08 (20130101) C12M 23/10 (20130101) C12M 23/12 (20130101) C12M 23/16 (20130101) C12M 23/50 (20130101) C12M 23/58 (20130101) C12M 27/02 (20130101) C12M 27/12 (20130101) C12M 29/10 (20130101) Original (OR) Class C12M 35/02 (20130101) C12M 35/04 (20130101) C12M 41/48 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447747 | Meyer et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Everett Hurteau Meyer (Belmont, California); Robert S. Negrin (Stanford, California) |
| ABSTRACT | The disclosure provides methods for improved hematopoietic stem cell transplantations, including methods to enhance protection from graft versus host disease while maintaining effective immune responses such as graft versus tumor immune responses. The disclosure provides methods for administering, for example, hematopoietic stem and progenitor cells, regulatory T cells, and conventional T cells, wherein the conventional T cells are administered after the hematopoietic stem and progenitor cells and regulatory T cells. The disclosure also provides methods for administering, for example, hematopoietic stem and progenitor cells, regulatory T cells, and conventional T cells, wherein the regulatory T cells have not been cryopreserved prior to administration. |
| FILED | Thursday, September 24, 2020 |
| APPL NO | 17/031213 |
| ART UNIT | 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/436 (20130101) A61K 31/445 (20130101) A61K 35/17 (20130101) A61K 35/28 (20130101) A61K 39/001 (20130101) A61K 2035/122 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) A61P 37/06 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0637 (20130101) C12N 5/0647 (20130101) Original (OR) Class C12N 2506/11 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447753 | Smith et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois); Board of Regents of the University of Nebraska (Lincoln, Nebraska); Trustees of Tufts College (AKA Tufts University) (Medford, Massachusetts) |
| ASSIGNEE(S) | Northwestern University (Evanston, Illinois); Board of Regents of the University of Nebraska (Lincoln, Nebraska); Trustees of Tufts College (AKA Tufts University) (Medford, Massachusetts) |
| INVENTOR(S) | Gregory A. Smith (Oak Park, Illinois); Patricia Jane Sollars (Lincoln, Nebraska); Gary Edward Pickard (Lincoln, Nebraska); Ekaterina E. Heldwein (Belmont, Massachusetts) |
| ABSTRACT | Provided herein are compositions and methods for vaccination and research applications. In particular, provided herein are non-neuroinvasive herpesviruses and alpha herpesviruses and uses thereof. |
| FILED | Wednesday, May 06, 2020 |
| APPL NO | 16/868243 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/763 (20130101) A61K 39/12 (20130101) A61K 39/25 (20130101) A61K 39/245 (20130101) A61K 2039/5254 (20130101) Peptides C07K 14/005 (20130101) C07K 2299/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class C12N 2710/16034 (20130101) C12N 2710/16621 (20130101) C12N 2710/16622 (20130101) C12N 2710/16632 (20130101) C12N 2710/16633 (20130101) C12N 2710/16634 (20130101) C12N 2710/16643 (20130101) C12N 2710/16721 (20130101) C12N 2710/16722 (20130101) C12N 2710/16732 (20130101) C12N 2710/16733 (20130101) C12N 2710/16734 (20130101) C12N 2710/16743 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447764 | Wang |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Lei Wang (San Francisco, California) |
| ABSTRACT | Provided herein are novel materials and methods for site-specific incorporation of phosphotyrosines into proteins. The novel methods of the invention encompass the use of a novel aminoacyl tRNA synthetase capable of charging compatible tRNAs with a phosphotyrosine precursor. The phosphotyrosine precursor is then incorporated, site-specifically, into a protein at sites where phosphotyrosine residues are desired. The phosphotyrosine precursors are subsequently treated to convert them into phosphotyrosine residues, yielding proteins with phosphotyrosines at selected sites. The scope of the invention encompasses novel aminoacyl tRNA synthetases, novel phosphotyrosine precursors, and methods of using these materials to create site-specific phosphorylated tyrosine residues in a protein. |
| FILED | Tuesday, February 13, 2018 |
| APPL NO | 16/484757 |
| ART UNIT | 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/12 (20130101) C07F 9/242 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/88 (20130101) Original (OR) Class C12N 9/93 (20130101) C12N 15/52 (20130101) C12N 15/63 (20130101) C12N 2310/314 (20130101) Enzymes C12Y 601/01026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447769 | Zhao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Yangbing Zhao (Lumberton, New Jersey); Jiangtao Ren (Philadelphia, Pennsylvania) |
| ABSTRACT | The present disclosure provides gene edited modified immune cells or precursors thereof (e.g., gene edited modified T cells) comprising an exogenous T cell receptor (TCR) and/or a chimeric antigen receptor (CAR) having specificity for a target antigen, and an insertion and/or deletion in one or more endogenous gene loci, wherein the endogenous gene loci encode regulators of T cell function, thereby resulting in immune cells having enhanced function. Compositions and methods of treatment are also provided. The present invention provides methods of screening for TCR- or CAR-T cells with enhanced immune function (e.g., T cell efficacy, T cell memory, and/or T cell persistence). |
| FILED | Tuesday, March 26, 2019 |
| APPL NO | 16/365326 |
| ART UNIT | 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 9/22 (20130101) C12N 15/11 (20130101) Original (OR) Class C12N 15/1082 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447770 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David R. Liu (Cambridge, Massachusetts); Andrew Vito Anzalone (Cambridge, Massachusetts); Gregory Newby (Cambridge, Massachusetts); Kelcee Everette (Cambridge, Massachusetts) |
| ABSTRACT | Compositions and methods are provided herein for conducting prime editing of a target DNA molecule (e.g., a genome) that enables the incorporation of a nucleotide change and/or targeted mutagenesis. The compositions include fusion proteins comprising nucleic acid programmable DNA binding proteins (napDNAbp) and a polymerase (e.g., reverse transcriptase), which is guided to a specific DNA sequence by a modified guide RNA, named a PEgRNA. The PEgRNA has been altered (relative to a standard guide RNA) to comprise an extended portion that provides a DNA synthesis template sequence which encodes a single strand DNA flap which is synthesized by the polymerase of the fusion protein and which becomes incorporated into the target DNA molecule. |
| FILED | Wednesday, March 31, 2021 |
| APPL NO | 17/219672 |
| ART UNIT | 1699 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Peptides C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/1276 (20130101) C12N 15/11 (20130101) Original (OR) Class C12N 15/907 (20130101) C12N 2310/20 (20170501) C12N 2310/3519 (20130101) Enzymes C12Y 207/07049 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447796 | Anderson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| INVENTOR(S) | Daniel G. Anderson (Framingham, Massachusetts); Robert Alexander Wesselhoeft (Boston, Massachusetts); Piotr S. Kowalski (Allston, Massachusetts) |
| ABSTRACT | Methods and constructs for engineering circular RNA are disclosed. In some embodiments, the methods and constructs comprise a vector for making circular RNA, the vector comprising the following elements operably connected to each other and arranged in the following sequence: a.) a 5′ homology arm, b.) a 3′ group I intron fragment containing a 3′ splice site dinucleotide, c.) optionally, a 5′ spacer sequence, d.) a protein coding or noncoding region, e.) optionally, a 3′ spacer sequence, f) a 5′ Group I intron fragment containing a 5′ splice site dinucleotide, and g.) a 3′ homology arm, the vector allowing production of a circular RNA that is translatable or biologically active inside eukaryotic cells. Methods for purifying the circular RNA produced by the vector and the use of nucleoside modifications in circular RNA produced by the vector are also disclosed. |
| FILED | Friday, October 01, 2021 |
| APPL NO | 17/492512 |
| ART UNIT | 1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Peptides C07K 16/2803 (20130101) C07K 2317/31 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) C12N 15/85 (20130101) Original (OR) Class C12N 2015/859 (20130101) C12N 2015/8518 (20130101) C12N 2800/70 (20130101) C12N 2800/107 (20130101) C12N 2800/202 (20130101) C12N 2840/55 (20130101) C12N 2840/60 (20130101) C12N 2840/203 (20130101) C12N 2999/007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447797 | Chiorini et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary, Department of Health and Human Service (Bethesda, Maryland) |
| INVENTOR(S) | John A. Chiorini (Dayton, Maryland); Giovanni Di Pasquale (Kensington, Maryland); Randy Chandler (Chevy Chase, Maryland); Charles P. Venditti (Potomac, Maryland) |
| ABSTRACT | The invention provides an adeno-associated viral (AAV) vector comprising a capsid comprising the amino acid sequence of SEQ ID NO: 4 or SEQ ID NO: 9, wherein the AAV vector further comprises a heterologous nucleic acid sequence, and wherein the heterologous nucleic acid sequence can encode the NGF-PTH fusion polypeptide or methylmalonyl CoA mutase enzyme. The invention also provides a polypeptide comprising nerve growth factor (NGF) signal peptide and parathyroid hormone (PTH), wherein the polypeptide can comprise, consist essentially of, or consist of the amino acid sequences of SEQ ID NO: 1 and SEQ ID NO: 2. The invention provides a nucleic acid encoding the polypeptide, a vector comprising the nucleic acid, and a composition comprising the polypeptide, nucleic acid, or vector, as well as treatment methods comprising the polypeptide, nucleic acid, vector, or composition. The invention further provides a method of treating methylmalonic acidaemia (MMA) in a mammal comprising administering an AAV vector comprising a heterologous nucleic acid sequence encoding methylmalonyl CoA mutase enzyme to the mammal. |
| FILED | Thursday, May 12, 2016 |
| APPL NO | 15/573214 |
| ART UNIT | 1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 5/14 (20180101) Peptides C07K 14/48 (20130101) C07K 14/635 (20130101) C07K 2319/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/90 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 2750/14121 (20130101) C12N 2750/14122 (20130101) C12N 2750/14143 (20130101) Enzymes C12Y 504/99002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447807 | Church et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | George M. Church (Brookline, Massachusetts); Evan R. Daugharthy (Cambridge, Massachusetts); Richard C. Terry (Carlisle, Massachusetts) |
| ABSTRACT | The present disclosure provides methods that combine RNA fluorescent in situ sequencing (FISSEQ) with other molecular detection modalities, forming an integrated panomic detection platform. In various embodiments, the present disclosure provides systems and methods to prepare a biological sample to preserve the spatial relationships of biomolecules of interest within the biological sample for FISSEQ detection. |
| FILED | Thursday, February 28, 2019 |
| APPL NO | 16/288200 |
| ART UNIT | 1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/50 (20130101) A61L 2400/16 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 2300/0636 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1093 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/682 (20130101) C12Q 1/6834 (20130101) C12Q 1/6874 (20130101) C12Q 1/6874 (20130101) C12Q 2543/10 (20130101) C12Q 2563/107 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6842 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447809 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David R. Liu (Lexington, Massachusetts); David Irby Bryson, Jr. (Dorchester, Massachusetts) |
| ABSTRACT | The disclosure provides amino acid sequence variants of orthogonal aminoacyl-tRNA synthetases (AARSs) having increased activity and selectivity compared to previous AARSs, and methods of producing the same. |
| FILED | Tuesday, July 03, 2018 |
| APPL NO | 16/628456 |
| ART UNIT | 1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/93 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/02 (20130101) Original (OR) Class Enzymes C12Y 601/01026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447822 | Chee |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Prognosys Biosciences, Inc. (San Diego, California) |
| ASSIGNEE(S) | Prognosys Biosciences, Inc. (San Diego, California) |
| INVENTOR(S) | Mark S. Chee (Encinitas, California) |
| ABSTRACT | The present invention provides oligonucleotide constructs, sets of such oligonucleotide constructs, and methods of using such oligonucleotide constructs to provide validated sequences or sets of validated sequences corresponding to desired ROIs. Such validated ROIs and constructs containing these have a wide variety of uses, including in synthetic biology, quantitative nucleic acid analysis, polymorphism and/or mutation screening, and the like. |
| FILED | Monday, October 21, 2019 |
| APPL NO | 16/659428 |
| ART UNIT | 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6809 (20130101) C12Q 1/6809 (20130101) C12Q 1/6809 (20130101) C12Q 1/6827 (20130101) C12Q 1/6827 (20130101) C12Q 1/6827 (20130101) C12Q 1/6834 (20130101) C12Q 1/6834 (20130101) C12Q 1/6834 (20130101) C12Q 1/6869 (20130101) Original (OR) Class C12Q 1/6874 (20130101) C12Q 1/6876 (20130101) C12Q 2525/131 (20130101) C12Q 2525/131 (20130101) C12Q 2525/131 (20130101) C12Q 2525/155 (20130101) C12Q 2525/155 (20130101) C12Q 2525/155 (20130101) C12Q 2537/143 (20130101) C12Q 2537/143 (20130101) C12Q 2537/143 (20130101) C12Q 2539/103 (20130101) C12Q 2539/103 (20130101) C12Q 2539/103 (20130101) C12Q 2563/149 (20130101) C12Q 2563/149 (20130101) C12Q 2563/149 (20130101) C12Q 2563/179 (20130101) C12Q 2563/179 (20130101) C12Q 2563/179 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447833 | Kurtz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | David M. Kurtz (San Francisco, California); Maximilian Diehn (San Carlos, California); Arash Ash Alizadeh (San Mateo, California) |
| ABSTRACT | Processes and materials to detect cancer from a biopsy are described. In some cases, cell-free nucleic acids can be sequenced, and the sequencing result can be utilized to detect sequences derived from a neoplasm. Detection of somatic variants occurring in phase can indicate the presence of cancer in a diagnostic scan and a clinical intervention can be performed. |
| FILED | Tuesday, November 16, 2021 |
| APPL NO | 17/455209 |
| ART UNIT | 1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1089 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) C12Q 1/6874 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/112 (20130101) C12Q 2600/156 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/10 (20190201) G16B 20/20 (20190201) G16B 30/00 (20190201) G16B 30/10 (20190201) G16B 35/20 (20190201) G16B 40/00 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/40 (20180101) G16H 10/60 (20180101) G16H 20/10 (20180101) G16H 50/20 (20180101) G16H 50/30 (20180101) G16H 50/70 (20180101) G16H 70/60 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447891 | Rout et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Rockefeller University (New York, New York) |
| ASSIGNEE(S) | The Rockefeller University (New York, New York) |
| INVENTOR(S) | Michael P. Rout (New York, New York); Brian T. Chait (New York, New York) |
| ABSTRACT | Provided are compositions and methods for producing large repertoires of recombinant nanobodies with high affinities and specificities against any antigen. Included are methods for making and identifying nanobodies produced by camelids, the nanobodies themselves, modifications of the nanobodies, expression vectors encoding the nanobodies, cDNAs encoding the nanobodies, cells comprising the expression vectors and/or cDNA, and methods of making the nanobodies recombinantly. Antigen-specific nanobodies and antigen binding fragments thereof having a Kd for the antigen in a sub-micromolar range are provided. |
| FILED | Tuesday, August 13, 2019 |
| APPL NO | 16/539308 |
| ART UNIT | 1639 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Peptides C07K 16/00 (20130101) C07K 16/44 (20130101) C07K 2317/22 (20130101) C07K 2317/92 (20130101) C07K 2317/569 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6876 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 30/04 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6857 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 30/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11448644 | Woodruff et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | Northwestern University (Evanston, Illinois) |
| INVENTOR(S) | Teresa K. Woodruff (Chicago, Illinois); Thomas V. O'Halloran (Chicago, Illinois); Alison M. Kim (Chicago, Illinois); Emily Que (Chicago, Illinois); Betty Kong (Chicago, Illinois); Miranda Bernhardt (Durham, North Carolina) |
| ABSTRACT | The invention relates generally to compositions and methods for the detection of zinc. In particular, compositions and methods are provided to detect changes in cellular zinc concentration and to correlate them to cellular phenomena. |
| FILED | Tuesday, July 16, 2019 |
| APPL NO | 16/512836 |
| ART UNIT | 1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/435 (20130101) Veterinary Instruments, Implements, Tools, or Methods A61D 19/04 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/643 (20130101) G01N 21/6428 (20130101) G01N 33/5091 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11448654 | Shu et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Xiaokun Shu (San Francisco, California); Qiang Zhang (Daly City, California); Chan-I Chung (San Francisco, California) |
| ABSTRACT | The invention is a novel reporter system for measuring protein-protein interactions. The system uses a pair of functionalized coiled coil subunits that spontaneously form two separate homo-oligomers when expressed in cells. The coiled coil subunits are functionalized with fluorescent proteins and complementary interacting proteins. Upon an activation stimulus which promotes the protein-protein interaction, the interacting proteins drive the formation of multivalent aggregates of the homo-oligomers in phase-shifted droplets. The highly concentrated fluorescent proteins in these structures provide high brightness over background fluorescence and a readily observed, quantitative and dynamic indicator of the protein-protein interaction. The reporters and assay methods are amenable to cells and whole organisms. |
| FILED | Tuesday, October 02, 2018 |
| APPL NO | 16/838023 |
| ART UNIT | 1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Peptides C07K 14/4705 (20130101) C07K 14/4746 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/12 (20130101) C12N 9/0028 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/542 (20130101) G01N 33/582 (20130101) G01N 33/6845 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11448714 | Nixdorf et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| ASSIGNEE(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| INVENTOR(S) | Donald Robert Nixdorf (Minneapolis, Minnesota); Ali Caglar Ozen (Minneapolis, Minnesota); Djaudat Idiyatullin (Minneapolis, Minnesota); Gregor Adriany (Minneapolis, Minnesota) |
| ABSTRACT | A multi-planar intraoral radio frequency (RF) coil apparatus for use in a magnetic resonance imaging system can include a housing having a shape configured to be positioned in an occlusal plane between an upper jaw and a lower jaw of a subject and a plurality of coil elements disposed within the housing. The plurality of coil elements includes a first coil element positioned in a first plane and a second coil element positioned in a second plane different from the first plane and substantially parallel to the first plane. The coil elements can be loop coil elements or dipole coil elements. |
| FILED | Monday, July 20, 2020 |
| APPL NO | 16/933855 |
| ART UNIT | 2896 — Printing/Measuring and Testing |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) Dentistry; Apparatus or Methods for Oral or Dental Hygiene A61C 19/04 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/34084 (20130101) G01R 33/34092 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11449989 | Tian et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Qiyuan Tian (Charlestown, Massachusetts); Susie Yi Huang (Boston, Massachusetts); Berkin Bilgic (Boston, Massachusetts); Jonathan R. Polimeni (Cambridge, Massachusetts) |
| ABSTRACT | Super-resolution images are generated from standard-resolution images acquired with a magnetic resonance imaging (“MRI”) system. More particularly, super-resolution (e.g., sub-millimeter isotropic resolution) images are generated from standard-resolution images (e.g., images with 1 mm or coarser isotropic resolution) using a deep learning algorithm, from which accurate cortical surface reconstructions can be generated. |
| FILED | Thursday, March 26, 2020 |
| APPL NO | 16/831061 |
| ART UNIT | 2662 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/5602 (20130101) Image Data Processing or Generation, in General G06T 3/4007 (20130101) G06T 3/4053 (20130101) G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 2207/10088 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11450082 | Kavanau et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Christopher L. Kavanau (Allentown, Pennsylvania) |
| ASSIGNEE(S) | Christopher L. Kavanau (Allentown, Pennsylvania) |
| INVENTOR(S) | Christopher L. Kavanau (Allentown, Pennsylvania); Luisa Montesano (Santa Monica, California) |
| ABSTRACT | In one embodiment, L dimensional images are trained, mapped, and aligned to an M dimensional topology to obtain azimuthal angles. The aligned L dimensional images are then trained and mapped to an N dimensional topology to obtain 2N vertex classifications. The azimuthal angles and the 2N vertex classifications are used to map L dimensional images into 0 dimensional images. |
| FILED | Monday, December 10, 2018 |
| APPL NO | 16/215616 |
| ART UNIT | 2667 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6217 (20130101) G06K 9/6251 (20130101) Image Data Processing or Generation, in General G06T 3/60 (20130101) G06T 5/002 (20130101) G06T 7/11 (20170101) G06T 7/155 (20170101) G06T 19/20 (20130101) G06T 2207/20216 (20130101) G06T 2219/2004 (20130101) Image or Video Recognition or Understanding G06V 10/24 (20220101) Original (OR) Class G06V 20/693 (20220101) G06V 2201/122 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11450148 | Radwin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin) |
| ASSIGNEE(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin) |
| INVENTOR(S) | Robert Radwin (Waunakee, Wisconsin); Xuan Wang (Madison, Wisconsin); Yu Hen Hu (Middleton, Wisconsin) |
| ABSTRACT | A monitoring system or tracking system may include an input port and a controller in communication with the input port. The input port may receive video from one or more image capturing devices. The image capturing device is optionally part of the monitoring system and in some cases includes at least part of the controller. The controller may be configured to receive video via the input port and identify a subject within frames of the video relative to a background within the frames. Further, the controller may be configured to identify dimensions, posture, hand location, feet location, twisting position/angle, and/or other parameters of the identified subject in frames of the video and determine when the subject is performing a task. Based on the dimensions and/or other parameters identified or extracted from the video during the predetermined task, the controller may output via the output port assessment information. |
| FILED | Friday, May 15, 2020 |
| APPL NO | 16/874883 |
| ART UNIT | 2668 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation |
| CURRENT CPC | Image or Video Recognition or Understanding G06V 20/46 (20220101) G06V 20/49 (20220101) G06V 40/23 (20220101) Original (OR) Class G06V 40/103 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11450223 | Jain et al. |
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| FUNDED BY |
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| APPLICANT(S) | Vignet Incorporated (Fairfax, Virginia) |
| ASSIGNEE(S) | VigNet Incorporated (Fairfax, Virginia) |
| INVENTOR(S) | Praduman Jain (Fairfax, Virginia); Dave Klein (Oakton, Virginia); Yue Cao (Vienna, Virginia); Neeta Jain (Fairfax, Virginia) |
| ABSTRACT | In some implementations, one or more computers provide data for an application configured to provide interactive content personalized for a user of a mobile device. The one or more computers obtain activity data for the user for a current segment of the program. The activity data can include interaction data indicating one or more interactions of the user with the application during the current segment and sensor data indicating one or more measurements separate from user input to the application. The one or more computers identify a subset of content for the current segment based data indicating on a current track or level assigned for the user. The one or more computers cause a selected portion of the content in the subset to be presented on the mobile device in response to a determination, based at least in part on the sensor data for the current segment, that one or more triggers or conditions defined by rules associated with the current track or level are satisfied. |
| FILED | Wednesday, October 28, 2020 |
| APPL NO | 17/082428 |
| ART UNIT | 2179 — Graphical User Interface and Document Processing |
| CURRENT CPC | Electric Digital Data Processing G06F 3/14 (20130101) G06F 3/1454 (20130101) G06F 8/61 (20130101) G06F 8/65 (20130101) G06F 9/453 (20180201) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 5/06 (20130101) G09B 7/02 (20130101) Original (OR) Class Arrangements or Circuits for Control of Indicating Devices Using Static Means to Present Variable Information G09G 2354/00 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/30 (20180101) G16H 20/70 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11450224 | Jain et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Vignet Incorporated (Fairfax, Virginia) |
| ASSIGNEE(S) | VigNet Incorporated (Fairfax, Virginia) |
| INVENTOR(S) | Praduman Jain (Fairfax, Virginia); Dave Klein (Oakton, Virginia); Yue Cao (Vienna, Virginia); Neeta Jain (Fairfax, Virginia) |
| ABSTRACT | In some implementations, one or more computers provide data for an application configured to provide interactive content personalized for a user of a mobile device. The one or more computers obtain activity data for the user for a current segment of the program. The activity data can include interaction data indicating one or more interactions of the user with the application during the current segment and sensor data indicating one or more measurements separate from user input to the application. The one or more computers identify a subset of content for the current segment based data indicating on a current track or level assigned for the user. The one or more computers cause a selected portion of the content in the subset to be presented on the mobile device in response to a determination, based at least in part on the sensor data for the current segment, that one or more triggers or conditions defined by rules associated with the current track or level are satisfied. |
| FILED | Wednesday, October 28, 2020 |
| APPL NO | 17/082482 |
| ART UNIT | 2179 — Graphical User Interface and Document Processing |
| CURRENT CPC | Electric Digital Data Processing G06F 3/14 (20130101) G06F 3/1454 (20130101) G06F 8/61 (20130101) G06F 8/65 (20130101) G06F 9/453 (20180201) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 5/06 (20130101) G09B 7/02 (20130101) Original (OR) Class Arrangements or Circuits for Control of Indicating Devices Using Static Means to Present Variable Information G09G 2354/00 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/30 (20180101) G16H 20/70 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11450413 | Sarrafzadeh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Majid Sarrafzadeh (Anaheim Hills, California); Myung-Kyung Suh (Albuquerque, New Mexico) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Majid Sarrafzadeh (Anaheim Hills, California); Myung-Kyung Suh (Albuquerque, New Mexico) |
| ABSTRACT | Congestive heart failure (CHF) is a leading cause of death in the United States. WANDA is a wireless health project that leverages sensor technology and wireless communication to monitor the health status of patients with CHF. The first pilot study of WANDA showed the system's effectiveness for patients with CHF. However, WANDA experienced a considerable amount of missing data due to system misuse, nonuse, and failure. Missing data is highly undesirable as automated alarms may fail to notify healthcare professionals of potentially dangerous patient conditions. Embodiments of the present disclosure may utilize machine learning techniques including projection adjustment by contribution estimation regression (PACE), Bayesian methods, and voting feature interval (VFI) algorithms to predict both non-binomial and binomial data. The experimental results show that the aforementioned algorithms are superior to other methods with high accuracy and recall. |
| FILED | Monday, August 27, 2012 |
| APPL NO | 14/241431 |
| ART UNIT | 3626 — Business Methods - Incentive Programs, Coupons; Operations Research; Electronic Shopping; Health Care; Point of Sale, Inventory, Accounting; Cost/ Price, Reservations, Shipping and Transportation; Business Processing |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/7264 (20130101) A61B 5/7267 (20130101) Computer Systems Based on Specific Computational Models G06N 7/005 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) Original (OR) Class G16H 40/67 (20180101) G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 11445809 | Swain et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Florida Institute of Technology, Inc. (Melbourne, Florida) |
| ASSIGNEE(S) | Florida Institute of technology, Inc. (Melbourne, Florida) |
| INVENTOR(S) | Geoffrey Swain (Melbourne, Florida); Michael Harper (Ponte Vedra, Florida); Melissa Tribou (Satellite Beach, Florida); Harrison Arthur Gardner (Palm Bay, Florida); Caglar Erdogan (Melbourne, Florida) |
| ABSTRACT | A rotating grooming brush comprising a brush hub having grooming elements and shroud elements, and method for grooming a surface having an unwanted material thereon. The elements extend from the brush hub and may be positioned near its outer periphery. The elements may be grooming elements forming an array and shroud elements forming a shroud array. A rigid or elastomeric shroud extending from the brush hub surface may optionally be included about the edge of the brush hub, to the outside of the grooming elements. Rotation of the grooming attachment brush causes a low pressure region to build in the central area of the brush. This low pressure region creates a resulting force that forcefully attracts the grooming attachment brush to the surface to be groomed. The resulting force is controlled by the diameter of the brush hub, arrangement, of the elements and the speed of rotation. |
| FILED | Thursday, March 21, 2019 |
| APPL NO | 16/361177 |
| ART UNIT | 3723 — Manufacturing Devices & Processes, Machine Tools & Hand Tools Group Art Units |
| CURRENT CPC | Brushes A46B 9/02 (20130101) Original (OR) Class A46B 13/008 (20130101) Cleaning in General; Prevention of Fouling in General B08B 1/002 (20130101) B08B 1/04 (20130101) Ships or Other Waterborne Vessels; Equipment for Shipping B63B 59/06 (20130101) B63B 59/08 (20130101) Hydraulic Engineering E02B 17/0034 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11445941 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Zhongping Chen (Irvine, California); Youmin He (Irvine, California); Joseph Jing (Irvine, California); Yueqiao Qu (Irvine, California); Andrew Emon Heidari (Irvine, California); Jason Chen (Irvine, California) |
| ABSTRACT | Ciliary motion in the upper airway is the primary mechanism by which the body transports foreign particulate out of the respiratory system. The ciliary beating frequency (CBF) is often disrupted with the onset of disease. Current imaging of ciliary motion relies on microscopy and high speed cameras, which cannot be easily adapted to in-vivo imaging. M-mode optical coherence tomography (OCT) imaging is capable of visualization of ciliary activity, but the field of view is limited. The present invention features the development of a spectrally encoded interferometric microscopy (SEIM) system using a phase-resolved Doppler (PRD) algorithm to measure and map the ciliary beating frequency within an on face region. This novel high speed, high resolution system allows for visualization of both temporal and spatial ciliary motion patterns. |
| FILED | Monday, February 03, 2020 |
| APPL NO | 16/780659 |
| ART UNIT | 2488 — Recording and Compression |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/005 (20130101) A61B 1/063 (20130101) A61B 1/00096 (20130101) A61B 1/00149 (20130101) A61B 1/00172 (20130101) A61B 1/00177 (20130101) A61B 1/267 (20130101) A61B 5/0066 (20130101) A61B 5/1128 (20130101) Original (OR) Class Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/02004 (20130101) G01B 9/02041 (20130101) Optical Elements, Systems, or Apparatus G02B 21/0028 (20130101) G02B 21/0048 (20130101) G02B 21/0056 (20130101) G02B 21/365 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11446004 | Mehanian et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Tokitae LLC (Bellevue, Washington) |
| ASSIGNEE(S) | Tokitae LLC (Bellevue, Washington) |
| INVENTOR(S) | Courosh Mehanian (Redmond, Washington); Sebastian Wachsmann-Hogiu (Montreal, Canada); Benjamin K. Wilson (Snoqualmie, Washington); Xinliang Zheng (Issaquah, Washington) |
| ABSTRACT | Embodiments disclosed herein are directed to systems and methods for determining if a fluid is present in a body region. The systems and methods include using ultrasound systems having operational parameters that provide ultrasound echo maps having high resolution B-line artefacts. |
| FILED | Tuesday, May 22, 2018 |
| APPL NO | 15/985808 |
| ART UNIT | 3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/7264 (20130101) A61B 8/14 (20130101) A61B 8/54 (20130101) A61B 8/085 (20130101) A61B 8/0833 (20130101) A61B 8/4444 (20130101) Original (OR) Class A61B 8/4483 (20130101) A61B 8/4488 (20130101) A61B 8/5246 (20130101) A61B 8/5269 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/5206 (20130101) G01S 7/52047 (20130101) G01S 15/8915 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11446008 | Mehanian et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Tokitae, LLC (Bellevue, Washington) |
| ASSIGNEE(S) | Tokitae LLC (Bellevue, Washington) |
| INVENTOR(S) | Courosh Mehanian (Redmond, Washington); Sourabh Kulhare (Bellevue, Washington); Xinliang Zheng (Issaquah, Washington); Benjamin K. Wilson (Snoqualmie, Washington) |
| ABSTRACT | In an embodiment, an intelligent system includes an electronic circuit configured to execute a neural network, to detect at least one feature in an image of a body portion while executing the neural network, and to determine a respective position and a respective class of each of the detected at least one feature while executing the neural network. For example, such a system can execute a neural network to detect at least one feature in an image of a lung, to determine a respective position within the image of each detected feature, and to classify each of the detected features as one of the following: A-line, B-line, pleural line, consolidation, and pleural effusion. |
| FILED | Wednesday, August 14, 2019 |
| APPL NO | 16/540759 |
| ART UNIT | 2661 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/486 (20130101) A61B 8/5207 (20130101) Original (OR) Class Electric Digital Data Processing G06F 17/18 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/628 (20130101) G06K 9/6218 (20130101) G06K 9/6277 (20130101) Computer Systems Based on Specific Computational Models G06N 3/082 (20130101) G06N 3/084 (20130101) G06N 5/046 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 7/70 (20170101) G06T 2207/10132 (20130101) G06T 2207/20084 (20130101) G06T 2207/30061 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11446046 | Nelson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NUtech Ventures (Lincoln, Nebraska) |
| ASSIGNEE(S) | NUtech Ventures (Lincoln, Nebraska) |
| INVENTOR(S) | Carl A. Nelson (Lincoln, Nebraska); Raul Gonzalo Garay Romero (Lincoln, Nebraska) |
| ABSTRACT | A surgical tool exchanger includes an elongated base having a first end and a second end. The surgical tool exchanger also includes an end effector configured to receive a replaceable surgical tool and an elbow configured to allow the end effector to pivot with respect to the elongated base. The surgical tool exchanger further includes an actuator connected to the second end of the elongated base. The actuator is operatively connected to the end effector and is configured to cause the end effector to retain the replaceable surgical tool in a first actuation state and release the replaceable surgical tool in a second actuation state. |
| FILED | Monday, August 27, 2018 |
| APPL NO | 16/113686 |
| ART UNIT | 3771 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/29 (20130101) Original (OR) Class A61B 17/3421 (20130101) A61B 18/1442 (20130101) A61B 34/30 (20160201) A61B 2017/2901 (20130101) A61B 2017/2927 (20130101) A61B 2034/302 (20160201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11446267 | Sirianni et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | DIGNITY HEALTH (Phoenix, Arizona) |
| ASSIGNEE(S) | Dignity Health (Phoenix, Arizona) |
| INVENTOR(S) | Rachael Sirianni (Sugar Land, Texas); David Alexandro Medina (Phoenix, Arizona); Eugene Chung (San Antonio, Texas) |
| ABSTRACT | The invention relates to a composition and use of the composition in the treatment of a disorder, for example, a neurological disease associated with retinoid signaling. The invention also includes the use of a retinoid encapsulated in nanoparticles. The retinoid encapsulated nanoparticles are adapted to increasing lifespan and conferring neuroprotective effects such as preserving motor units, reducing motor impairment, or reducing neuroinflammation in a subject. |
| FILED | Friday, June 15, 2018 |
| APPL NO | 16/616222 |
| ART UNIT | 1626 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5153 (20130101) A61K 31/192 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11446308 | Zuo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | St. Jude Children's Research Hospital (Memphis, Tennessee) |
| ASSIGNEE(S) | St Jude Children's Research Hospital (, None) |
| INVENTOR(S) | Jian Zuo (Memphis, Tennessee); Tai Teitz (Memphis, Tennessee); Jie Fang (Memphis, Tennessee); Asli Goktug (Memphis, Tennessee); Taosheng Chen (Germantown, Tennessee); Jaeki Min (Memphis, Tennessee); R. Kiplin Guy (Memphis, Tennessee) |
| ABSTRACT | In one aspect, pharmaceutical compositions comprising a CDK2 inhibitor and one or more of at least one agent known to treat a hearing impairment and at least one agent known to prevent a hearing impairment, and methods of treating and/or preventing hearing impairments or disorders using the compositions are disclosed. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| FILED | Monday, December 09, 2019 |
| APPL NO | 16/707991 |
| ART UNIT | 1628 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/52 (20130101) A61K 31/55 (20130101) Original (OR) Class A61K 31/404 (20130101) A61K 31/454 (20130101) A61K 31/506 (20130101) A61K 31/519 (20130101) A61K 31/4015 (20130101) A61K 31/4155 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/16 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447022 | Bernhardt et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Boeing Company (Chicago, Illinois) |
| ASSIGNEE(S) | The Boeing Company (Chicago, Illinois) |
| INVENTOR(S) | Roger D. Bernhardt (St. Charles, Missouri); Daniel J. Clingman (Milton, Washington) |
| ABSTRACT | Structural members containing energy storage are disclosed. An example apparatus includes a first spring unit having a first plate spaced from a second plate and a first biasing element positioned between the first plate and the second plate. The first biasing element enables the first plate to move relative to the second plate in a direction along a longitudinal axis of the apparatus. A second spring unit has a third plate spaced from a fourth plate and a second biasing element positioned between the third plate and the fourth plate. The second biasing element enables the third plate to move relative to the fourth plate along the longitudinal axis of the apparatus. A battery is positioned between the first spring unit and the second spring unit. |
| FILED | Thursday, May 07, 2020 |
| APPL NO | 16/869191 |
| ART UNIT | 2836 — Electrical Circuits and Systems |
| CURRENT CPC | Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 50/66 (20190201) Original (OR) Class Aeroplanes; Helicopters B64C 3/187 (20130101) B64C 39/024 (20130101) B64C 2201/021 (20130101) B64C 2201/042 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447241 | Cox |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | LOCKHEED MARTIN CORPORATION (Bethesda, Maryland) |
| ASSIGNEE(S) | LOCKHEED MARTIN CORPORATION (Bethesda, Maryland) |
| INVENTOR(S) | John C. Cox (Jupiter, Florida) |
| ABSTRACT | A swashplate assembly of a rotary wing aircraft includes a first component, a second component arranged concentrically with the first component, and a bearing disposed between the first component and the second component. The bearing includes a spherical bearing and at least one bearing roller element and is operable to transmit torque between the first component and the second component. |
| FILED | Tuesday, July 14, 2020 |
| APPL NO | 16/928626 |
| ART UNIT | 3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Aeroplanes; Helicopters B64C 27/605 (20130101) Original (OR) Class Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/02 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/90 (20130101) F05D 2240/50 (20130101) F05D 2240/60 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447242 | Haldeman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Bell Textron Inc. (Fort Worth, Texas) |
| ASSIGNEE(S) | Textron Innovations Inc. (Providence, Rhode Island) |
| INVENTOR(S) | Andrew Paul Haldeman (Fort Worth, Texas); Paul Wayne Woolbright (Euless, Texas); Bryan Baskin (Arlington, Texas) |
| ABSTRACT | A rotor assembly includes a pitch spider, rotor blade assemblies, and pitch horn joints. The pitch spider has a body and pitch spider legs extending from the body. Each blade rotor assembly includes a rotor blade, a pitch adapter joined to the rotor blade and connecting the rotor blade to the rotor hub, and a pitch horn. Each pitch horn joint joins one of the rotor blade assemblies to a corresponding pitch spider leg. Each pitch horn joint includes a pitch horn joint bolt extending from the pitch horn of the rotor blade assembly to the pitch spider leg along a pitch horn joint axis, the pitch horn joint bolt fixed to the pitch horn; a spherical bearing having an inner ring and an outer ring; and a slider sleeve coupled to the spherical bearing, the slider sleeve enabling the pitch horn to translate along the pitch horn joint axis. |
| FILED | Wednesday, October 28, 2020 |
| APPL NO | 17/082659 |
| ART UNIT | 3644 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Aeroplanes; Helicopters B64C 27/82 (20130101) B64C 27/605 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447272 | Lampazzi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lockheed Martin Corporation (Bethesda, Maryland) |
| ASSIGNEE(S) | LOCKHEED MARTIN CORPORATION (Bethesda, Maryland) |
| INVENTOR(S) | Margaret MacIsaac Lampazzi (Newtown, Connecticut); Carl John Pankok, Jr. (Philadelphia, Pennsylvania); Igor Cherepinsky (Sandy Hook, Connecticut) |
| ABSTRACT | A technique relates to interactive aircraft operation. An interactive electronic checklist is selected from a plurality of interactive electronic checklists, the interactive electronic checklists each comprising checklist tasks. It is perceived that one or more of the checklist tasks in the interactive electronic checklist is executable by an autonomous system. The one or more of the checklist tasks is performed using the autonomous system, an operator being designated to perform any other ones of the checklist tasks. |
| FILED | Wednesday, July 08, 2020 |
| APPL NO | 16/923143 |
| ART UNIT | 2171 — Graphical User Interface and Document Processing |
| CURRENT CPC | Ground or Aircraft-carrier-deck Installations Specially Adapted for Use in Connection With Aircraft; Designing, Manufacturing, Assembling, Cleaning, Maintaining or Repairing Aircraft, Not Otherwise Provided For; Handling, Transporting, Testing or Inspecting Aircraft Components, Not Otherwise Provided for B64F 5/60 (20170101) Original (OR) Class Electric Digital Data Processing G06F 3/0482 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447524 | Fears et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Kenan P. Fears (Alexandria, Virginia); Manoj K. Kolel-Veetil (Alexandria, Virginia) |
| ABSTRACT | Disclosed herein is a cyclic peptide polymer. R1, R2, and R3 are organic groups. Each R4 is a covalent bond, methylene, ethylene, n-propylene, or n-butylene. Each X is —NH—, —O—, or —O—CO—. The values m and n are nonnegative integers having a sum of at least 1. The value p is an integer greater than 1. The cyclic peptide polymer may be made by providing a first cyclic peptide monomer having a protecting group on the X group, covalently binding the —CO—OH group of the first cyclic peptide monomer to a solid support having a carboxylic acid-reactive group, converting the protecting group to —XH, reacting the —XH group with the —CO—OH group of an additional cyclic peptide monomer, optionally repeating the converting and reacting steps with further additional cyclic peptide monomers, and cleaving the cyclic peptide polymer from the solid support. |
| FILED | Thursday, November 19, 2020 |
| APPL NO | 16/952876 |
| ART UNIT | 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 43/713 (20130101) Peptides C07K 5/12 (20130101) Original (OR) Class C07K 5/123 (20130101) C07K 7/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447533 | Bishop et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | George Mason Research Foundation, Inc. (Fairfax, Virginia) |
| ASSIGNEE(S) | GEORGE MASON RESEARCH FOUNDATION, INC. (Fairfax, Virginia) |
| INVENTOR(S) | Barney Bishop (Annandale, Virginia); Saswata K. Sahoo (Silver Spring, Maryland); Justin Davis (Suffolk, Virginia) |
| ABSTRACT | Peptides and conjugates are described herein, including peptides having antimicrobial and/or anticancer properties, as are compositions, articles, and kits comprising such peptides and conjugates, and methods for using the peptides and conjugates. |
| FILED | Wednesday, December 11, 2019 |
| APPL NO | 16/710921 |
| ART UNIT | 1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 47/65 (20170801) Peptides C07K 14/001 (20130101) C07K 14/4723 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447541 | Westendorf et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | AbCellera Biologies Inc. (Vancouver, Canada); The United States of America, as represented by the Secretary, Department of Health and Human Svcs. (Bethesda, Maryland) |
| ASSIGNEE(S) | AbCellera Biologies Inc. (Vancouver, Canada); The United States of America, as represented by the Secretary, Department of Health and Human Svcs. (Bethesda, Maryland) |
| INVENTOR(S) | Kathryn Westendorf (Vancouver, Canada); Stefanie Zentelis (Vancouver, Canada); Krithika Muthuraman (Toronto, Canada); Kevin Jepson (Vancouver, Canada); Ester Falconer (Vancouver, Canada); John Mascola (Bethesda, Maryland); Barney Graham (Bethesda, Maryland); Kizzmekia Corbett (Bethesda, Maryland); Julie Ledgerwood (Bethesda, Maryland); Lingshu Wang (Bethesda, Maryland); Olubukola Abiona (Bethesda, Maryland); Wei Shi (Bethesda, Maryland); Wing-pui Kong (Bethesda, Maryland); Yi Zhang (Bethesda, Maryland); Bryan Edward Jones (San Diego, California); Denisa Foster (San Diego, California); Julian Davies (La Jolla, California); Qing Chai (San Diego, California); Christopher Carl Frye (Bargersville, Indiana); Ganapathy Gopalrathnam (Fishers, Indiana); Jörg Hendle (San Diego, California); John Michael Sauder (Carlsbad, California); Jeffrey Streetman Boyles (Indianapolis, Indiana); Anna Pustilnik (San Diego, California) |
| ABSTRACT | Antibodies that bind SARS-CoV Spike protein, SARS-CoV-2 Spike protein, and methods of using same for treating or preventing conditions associated with SARS or COVID-19 and for detecting SARS-CoV or SARS-CoV-2. |
| FILED | Tuesday, June 22, 2021 |
| APPL NO | 17/354476 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/02 (20130101) A61K 47/26 (20130101) A61K 47/68 (20170801) A61K 47/183 (20130101) A61K 2039/54 (20130101) A61K 2039/545 (20130101) Peptides C07K 16/10 (20130101) Original (OR) Class C07K 2317/76 (20130101) C07K 2317/565 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447659 | Benkoski et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Jason J. Benkoski (Catonsville, Maryland); Rengaswamy Srinivasan (Ellicott City, Maryland); Christopher M. Hoffman, Jr. (Odenton, Maryland); Keith S. Caruso (Catonsville, Maryland) |
| ABSTRACT | Coating compositions include a binder that has a first polymeric material that does not undergo ultraviolet (UV) degradation and/or does not absorb UV radiation/light. The coating compositions may further include at least a first UV-reflective pigment dispersed throughout the binder. The coating compositions may be provided in a cured form as a solid coating layer that may overly at least a portion of a substrate. |
| FILED | Tuesday, March 03, 2020 |
| APPL NO | 16/807227 |
| ART UNIT | 1767 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/22 (20130101) C08K 3/26 (20130101) C08K 2003/265 (20130101) C08K 2003/2296 (20130101) C08K 2201/003 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 183/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447796 | Anderson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| INVENTOR(S) | Daniel G. Anderson (Framingham, Massachusetts); Robert Alexander Wesselhoeft (Boston, Massachusetts); Piotr S. Kowalski (Allston, Massachusetts) |
| ABSTRACT | Methods and constructs for engineering circular RNA are disclosed. In some embodiments, the methods and constructs comprise a vector for making circular RNA, the vector comprising the following elements operably connected to each other and arranged in the following sequence: a.) a 5′ homology arm, b.) a 3′ group I intron fragment containing a 3′ splice site dinucleotide, c.) optionally, a 5′ spacer sequence, d.) a protein coding or noncoding region, e.) optionally, a 3′ spacer sequence, f) a 5′ Group I intron fragment containing a 5′ splice site dinucleotide, and g.) a 3′ homology arm, the vector allowing production of a circular RNA that is translatable or biologically active inside eukaryotic cells. Methods for purifying the circular RNA produced by the vector and the use of nucleoside modifications in circular RNA produced by the vector are also disclosed. |
| FILED | Friday, October 01, 2021 |
| APPL NO | 17/492512 |
| ART UNIT | 1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Peptides C07K 16/2803 (20130101) C07K 2317/31 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) C12N 15/85 (20130101) Original (OR) Class C12N 2015/859 (20130101) C12N 2015/8518 (20130101) C12N 2800/70 (20130101) C12N 2800/107 (20130101) C12N 2800/202 (20130101) C12N 2840/55 (20130101) C12N 2840/60 (20130101) C12N 2840/203 (20130101) C12N 2999/007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447809 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David R. Liu (Lexington, Massachusetts); David Irby Bryson, Jr. (Dorchester, Massachusetts) |
| ABSTRACT | The disclosure provides amino acid sequence variants of orthogonal aminoacyl-tRNA synthetases (AARSs) having increased activity and selectivity compared to previous AARSs, and methods of producing the same. |
| FILED | Tuesday, July 03, 2018 |
| APPL NO | 16/628456 |
| ART UNIT | 1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/93 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/02 (20130101) Original (OR) Class Enzymes C12Y 601/01026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447830 | Lin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Shiaw-Yih Lin (Bellaire, Texas); Daniel McGrail (Houston, Texas); Gordon Mills (Houston, Texas) |
| ABSTRACT | Methods for identifying and treating cancers that are DNA repair, such as homologous recombination (HR) repair, defective or sensitive to PARP inhibitors or platinum-based therapy. In some aspects, DNA repair, such as HR repair, defective cancers are treated with a PARP inhibitor therapy or cisplatin. Methods for sensitizing cancers to a PARP inhibitor therapy are also provided. |
| FILED | Monday, March 05, 2018 |
| APPL NO | 16/490588 |
| ART UNIT | 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 40/10 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447982 | Nguyen |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | Raytheon Company (Waltham, Massachusetts) |
| INVENTOR(S) | Ly Dinh Nguyen (Cypress, Texas) |
| ABSTRACT | A latch system for locking of a door to a cabinet comprises a latch receiver secured to the cabinet and having first and second ramps and a rest surface. The latch system further comprises a door latch comprising a handle, a shank coupled to the handle, and a cam latch supported by the shank. In response to rotation of the handle (in either rotational directions), the shank and the cam latch rotate to cause a lock arm of the cam latch to slidably interface with the first and second ramps of the latch receiver, and to seat against the rest surface, thus placing the door latch in a locked position. The latch receiver can have a plurality of ramps, and the lock arm can have a plurality of cam surfaces, so that it can be locked from both rotational directions. The door latch can have a compression load adjustment mechanism. |
| FILED | Tuesday, March 26, 2019 |
| APPL NO | 16/364629 |
| ART UNIT | 3675 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware |
| CURRENT CPC | Ships or Other Waterborne Vessels; Equipment for Shipping B63B 19/14 (20130101) B63B 19/26 (20130101) Locks; Accessories Therefor; Handcuffs E05B 17/0025 (20130101) E05B 65/001 (20130101) Original (OR) Class Bolts or Fastening Devices for Wings, Specially for Doors or Windows E05C 9/08 (20130101) E05C 17/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11448081 | Dyer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United Technologies Corporation (Farmington, Connecticut) |
| ASSIGNEE(S) | Raytheon Technologies Corporation (Farmington, Connecticut) |
| INVENTOR(S) | Timothy R. Dyer (Lake Worth Beach, Florida); Abhijeet Shrestha (Newington, Connecticut) |
| ABSTRACT | A machine has: an outer member; an inner member mounted for rotation about an axis relative to the outer member; and a seal system. The seal system has: a seal housing mounted to the outer member; one or more seal rings held by the seal housing and having an inner diameter surface; and a seal runner mounted to the inner member and having a first outer diameter surface portion contacting or facing the inner diameter surface of the one or more seal rings. The seal runner has a circumferential array of mounting features. One or more weights are mounted to one or more of the mounting features. |
| FILED | Friday, October 18, 2019 |
| APPL NO | 16/657739 |
| ART UNIT | 3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/027 (20130101) F01D 11/003 (20130101) Original (OR) Class Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/28 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2230/60 (20130101) F05D 2240/55 (20130101) F05D 2260/15 (20130101) F05D 2260/30 (20130101) F05D 2300/226 (20130101) F05D 2300/611 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11448165 | Carlson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Valley Tech Systems, Inc. (Reno, Nevada) |
| ASSIGNEE(S) | Valley Tech Systems, Inc. (Reno, Nevada) |
| INVENTOR(S) | Russell Carlson (Reno, Nevada); Dustin Barr (Reno, Nevada); Allen Yan (Reno, Nevada) |
| ABSTRACT | An attitude control system for a guided missile includes a gas generator, an accumulator coupled to the gas generator, and a valve positioned between the gas generator and the accumulator. The gas generator contains propellant that burns to provide hot gas to pressurize the accumulator. The valve is opened to recharge the accumulator with hot gas and closed when it is full. A vent valve can be included to extinguish the propellant in the gas generator. The accumulator can be coupled to thrusters that use the stored hot gas to adjust the attitude of the guided missile. |
| FILED | Monday, March 23, 2020 |
| APPL NO | 16/827588 |
| ART UNIT | 3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/26 (20130101) B64G 1/244 (20190501) Jet-propulsion Plants F02K 9/80 (20130101) F02K 9/94 (20130101) Original (OR) Class F02K 9/95 (20130101) F02K 9/805 (20130101) Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 15/01 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11448175 | Overman |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | GENERAL ELECTRIC COMPANY (Schenectady, New York) |
| INVENTOR(S) | Nicholas R. Overman (Sharonville, Ohio) |
| ABSTRACT | A fuel nozzle for a combustor includes a fuel body, a primary fuel passage having a primary fuel outlet, and a secondary fuel passage having a secondary fuel outlet, the secondary fuel passage being non-concentric with the primary fuel passage. The primary fuel outlet and the secondary fuel outlet are non-parallel. An axial centerline of the primary fuel outlet is angled with respect to an axial centerline of the primary fuel passage and an axial centerline of the secondary fuel outlet is colinear with an axial centerline of the secondary fuel passage. Also provided is a method of introducing non-concentric, non-parallel fuel flows to a combustor is also provided. |
| FILED | Thursday, June 03, 2021 |
| APPL NO | 17/337886 |
| ART UNIT | 3747 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Supplying Combustion Engines in General With Combustible Mixtures or Constituents Thereof F02M 21/0248 (20130101) F02M 45/086 (20130101) F02M 61/1813 (20130101) Original (OR) Class F02M 63/02 (20130101) F02M 2200/44 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11448235 | Parker et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | General Electric Company (Schenectady, New York) |
| INVENTOR(S) | David Vickery Parker (Lynn, Massachusetts); Wilhelm Ramon Hernandez (Lynn, Massachusetts); Basuki Srivastava (Lynn, Massachusetts); Paul Trimby (Lynn, Massachusetts) |
| ABSTRACT | An example compressor includes a casing having a main portion and an outer skirt collectively defining an annular plenum, an outlet guide vane coupled to the main portion, an actuator mounted outside the outer skirt, and a linkage coupled to the actuator and the outlet guide vane through the annular plenum. |
| FILED | Monday, July 06, 2020 |
| APPL NO | 16/921499 |
| ART UNIT | 3747 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 17/162 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 3/04 (20130101) Non-positive-displacement Pumps F04D 17/025 (20130101) F04D 19/02 (20130101) F04D 29/403 (20130101) F04D 29/462 (20130101) Original (OR) Class F04D 29/563 (20130101) F04D 29/4213 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2240/35 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11448483 | Curzan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cyan Systems (Santa Barbara, California) |
| ASSIGNEE(S) | Cyan Systems (Santa Barbara, California) |
| INVENTOR(S) | Jon Paul Curzan (Arroyo Grande, California); John Caulfield (Santa Barbara, California) |
| ABSTRACT | Techniques for tracing back a projectile to the projectile origin are described. A method includes detecting projectile track(s) in image(s). Each projectile track crosses multiple pixels in each image. The projectile track(s) correspond to projectile(s). The projectile track(s) in the image(s) are translated to traceback path(s). The traceback path includes a known location and a projectile origin (e.g. the location at which the projectile originated, also termed the shooter's location). |
| FILED | Thursday, April 23, 2020 |
| APPL NO | 16/856517 |
| ART UNIT | 2633 — Digital Communications |
| CURRENT CPC | Weapon Sights; Aiming F41G 3/142 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 7/20 (20130101) G06T 7/70 (20170101) G06T 11/00 (20130101) G06T 2207/10048 (20130101) Pictorial Communication, e.g Television H04N 5/23299 (20180801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11448486 | Gallimore et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Harkind Dynamics, LLC (Denver, Colorado) |
| ASSIGNEE(S) | HARKIND DYNAMICS, LLC (, None) |
| INVENTOR(S) | Craig Allen Gallimore (Denver, Colorado); Kelley Stewart Weiland (Fredericksburg, Virginia) |
| ABSTRACT | An intelligent munition can position circuitry in a 12 gauge form factor that detects the distance from a target in real-time in order to deploy a parachute to slow the munition to a speed that is conducive to accurate, but non-lethal, deployment of at least one electrode toward the target. The munition can intelligently discharge electrical charge into the target via an electrode to disable the target. The munition may further monitor the target and deliver a subsequent electrical discharge in response to detected target movement. |
| FILED | Tuesday, September 01, 2020 |
| APPL NO | 17/009298 |
| ART UNIT | 3641 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Armour; Armoured Turrets; Armoured or Armed Vehicles; Means of Attack or Defence, e.g Camouflage, in General F41H 13/0031 (20130101) Original (OR) Class Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 7/02 (20130101) F42B 10/56 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11448561 | Hale et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Bell Helicopter Textron Inc. (Fort Worth, Texas) |
| ASSIGNEE(S) | Textron Innovations Inc. (Providence, Rhode Island) |
| INVENTOR(S) | Rodney Keith Hale (Joshua, Texas); Ron L. Woods (Weatherford, Texas) |
| ABSTRACT | Embodiments are directed to a drive shaft apparatus comprising a first rotary member and a second rotary member arranged coaxially with said first rotary member. The rotary members are fixedly connected at a first end so that they rotate together. Each rotary member has a set of elements spaced apart around its circumference at a second end. The elements on the first rotary member are spaced apart from the elements on the second rotary member at rest. The first rotary member undergoes torsion when a load is applied during rotation, which causes the first rotary member elements to move closer to the second rotary member elements. The first elements engage the second elements when a torque load less than a yield torque is applied to the first rotary member, which transfers at least a portion of the torque load to the second rotary member. |
| FILED | Friday, April 05, 2019 |
| APPL NO | 16/375974 |
| ART UNIT | 2855 — Printing/Measuring and Testing |
| CURRENT CPC | Aeroplanes; Helicopters B64C 27/12 (20130101) Couplings for Transmitting Rotation; Clutches; Brakes F16D 1/12 (20130101) F16D 2300/18 (20130101) Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 3/104 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11448676 | Braje et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Danielle Ann Braje (Winchester, Massachusetts); Edward H. Chen (Cambridge, Massachusetts); Phillip R. Hemmer (College Station, Texas) |
| ABSTRACT | Sensing the electric or strain field experienced by a sample containing a crystal host comprising of solid state defects under a zero-bias magnetic field can yield a very sensitive measurement. Sensing is based on the spin states of the solid-state defects. Upon absorption of suitable microwave (and optical) radiation, the solid-state defects emit fluorescence associated with hyperfine transitions. The fluorescence is sensitive to electric and/or strain fields and is used to determine the magnitude and/or direction of the field of interest. The present apparatus is configured to control and modulate the assembly of individual components to maintain a zero-bias magnetic field, generate an Optically Detected Magnetic Resonance (ODMR) spectrum (with or without optical excitation) using appropriate microwave radiation, detect signals based on the hyperfine state transitions that are sensitive to electric/strain fields, and to quantify the magnitude and direction of the field of interest. |
| FILED | Monday, March 16, 2020 |
| APPL NO | 16/819268 |
| ART UNIT | 2867 — Printing/Measuring and Testing |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 29/0885 (20130101) Original (OR) Class G01R 33/323 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11448767 | Gupta et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin) |
| INVENTOR(S) | Mohit Gupta (Madison, Wisconsin); Anant Gupta (Madison, Wisconsin); Atul Ingle (Madison, Wisconsin) |
| ABSTRACT | In accordance with some embodiments, systems, methods, and media for asynchronous single photon depth imaging with improved precision in ambient light conditions are provided. In some embodiments, the system comprises: a light source; a detector configured to detect arrival of individual photons, and enter a dead time after a detection; a processor programmed to: cause the light source to emit pulses toward a scene point at the beginning of light source cycles each corresponding to B time bins; cause the detector to enter an acquisition window at a first time bin position; cause the detector to enter another acquisition window at a shifted time bin position; record photon arrival times; associate each photon arrival time with a time bin; and estimate a depth of the scene point based on a number of photon detection events at each time bin, and a denominator corresponding to each time bin. |
| FILED | Friday, June 07, 2019 |
| APPL NO | 16/434611 |
| ART UNIT | 2483 — Recording and Compression |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 1/4204 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/4816 (20130101) G01S 17/10 (20130101) G01S 17/89 (20130101) G01S 17/894 (20200101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11448824 | Mastro |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Michael A. Mastro (Fairfax, Virginia) |
| ABSTRACT | A hyperbolic metamaterial assembly comprising alternating one or more first layers and one or more second layers forming a hyperbolic metamaterial, the one or more first layers comprising an intrinsic or non-degenerate extrinsic semiconductor and the one or more second layers comprising a two-dimensional electron or hole gas, wherein one of in-plane or out-of-plane permittivity of the hyperbolic metamaterial assembly is negative and the other is positive. |
| FILED | Monday, March 21, 2016 |
| APPL NO | 15/075580 |
| ART UNIT | 2829 — Semiconductors/Memory |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 1/002 (20130101) G02B 6/1225 (20130101) Original (OR) Class G02B 6/12004 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/01708 (20130101) G02F 2202/30 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/1046 (20130101) H01S 5/32341 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11448881 | Browne |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vision Products, LLC (Los Gatos, California) |
| ASSIGNEE(S) | Vision Products, LLC (Los Gatos, California) |
| INVENTOR(S) | Michael P. Browne (San Mateo, California) |
| ABSTRACT | A wide field of view night vision system is described. The system comprises a head attachment apparatus configured to attach to a user's head and a night vision subsystem. The night vision subsystem comprises one or more night vision image sensors attached to the head attachment apparatus. Each sensor receives input light and produces a digital image of the input light. A processor processes the digital image(s) to produce a wide-field image. The wide-field image spans at least 60 degrees of a user's horizontal field of view. A display and eyepiece attached to the head attachment apparatus receives and displays the wide-field image. The eyepiece is positionable between the display and the user's eye to image the wide-field image into the user's eye. |
| FILED | Monday, August 05, 2019 |
| APPL NO | 16/532407 |
| ART UNIT | 2485 — Recording and Compression |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 27/017 (20130101) Original (OR) Class G02B 2027/011 (20130101) G02B 2027/014 (20130101) G02B 2027/0123 (20130101) G02B 2027/0138 (20130101) Pictorial Communication, e.g Television H04N 5/33 (20130101) H04N 5/2258 (20130101) H04N 5/23238 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11448939 | Choi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute ofTechnology (Cambridge, Massachusetts) |
| INVENTOR(S) | Hyeongrak Choi (Cambridge, Massachusetts); Dirk Robert Englund (Brookline, Massachusetts) |
| ABSTRACT | It remains a challenge to generate coherent radiation in the spectral range of 0.1-10 THz (“the THz gap”), a band for applications ranging from spectroscopy to security and high-speed wireless communications. Here, we disclose how to produce coherent radiation spanning the THz gap using efficient second-harmonic generation (SHG) in low-loss dielectric structures, starting from an electronic oscillator (EO) that generates coherent radiation at frequencies of about 100 GHz. The EO is coupled to cascaded, hybrid THz-band dielectric cavities that combine (1) extreme field concentration in high-quality-factor resonators with (2) nonlinear materials enhanced by phonon resonances. These cavities convert the input radiation into higher-frequency coherent radiation at conversion efficiencies of >103%/W, making it possible to bridge the THz gap with 1 W of input power. This approach enables efficient, cascaded parametric frequency converters, representing a new generation of light sources extensible into the mid-IR spectrum and beyond. |
| FILED | Monday, July 26, 2021 |
| APPL NO | 17/384861 |
| ART UNIT | 2874 — Optics |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/37 (20130101) G02F 1/392 (20210101) Original (OR) Class G02F 1/3503 (20210101) G02F 1/3551 (20130101) G02F 2202/32 (20130101) G02F 2203/13 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11448965 | Zheng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Yuebing Zheng (Austin, Texas); Linhan Lin (Austin, Texas); Jingang Li (Austin, Texas) |
| ABSTRACT | Disclosed herein are methods for patterning two-dimensional atomic layer materials, the methods comprising: illuminating a first location of an optothermal substrate with electromagnetic radiation, wherein the optothermal substrate converts at least a portion of the electromagnetic radiation into thermal energy, and wherein the optothermal substrate is in thermal contact with a two-dimensional atomic layer material; thereby: generating an ablation region at a location of the two-dimensional atomic layer material proximate to the first location of the optothermal substrate, wherein at least a portion of the ablation region has a temperature sufficient to ablate at least a portion of the two-dimensional atomic layer material within the ablation region, thereby patterning the two-dimensional atomic layer material. Also disclosed herein are systems for performing the methods described herein, patterned two-dimensional atomic layer materials made by the methods described herein and methods of use thereof. |
| FILED | Monday, July 22, 2019 |
| APPL NO | 17/262015 |
| ART UNIT | 2882 — Optics |
| CURRENT CPC | Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/202 (20130101) Original (OR) Class G03F 7/213 (20130101) G03F 7/702 (20130101) G03F 7/704 (20130101) G03F 7/2053 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11449384 | Rosenblum et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | Yale University (New Haven, Connecticut) |
| INVENTOR(S) | Serge Rosenblum (New Haven, Connecticut); Philip Reinhold (New Haven, Connecticut); Liang Jiang (Guilford, Connecticut); Steven M. Girvin (Hamden, Connecticut); Luigi Frunzio (North Haven, Connecticut); Michel Devoret (New Haven, Connecticut); Robert J. Schoelkopf, III (Madison, Connecticut) |
| ABSTRACT | Techniques for providing hardware-efficient fault-tolerant quantum operations are provided. In some aspects a cavity and an ancilla transmon are used to implement a quantum operation by encoding a logical qubit using more than two energy levels of the cavity, encoding information using more than two energy levels of the ancilla transmon, and creating an interaction between the cavity and the ancilla transmon that decouples at least one error type in the ancilla transmon from the cavity. |
| FILED | Saturday, January 05, 2019 |
| APPL NO | 16/959251 |
| ART UNIT | 2844 — Electrical Circuits and Systems |
| CURRENT CPC | Electric Digital Data Processing G06F 11/1004 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Pulse Technique H03K 19/003 (20130101) H03K 19/195 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11449586 | Mitchell et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | John Darby Mitchell (Beford, Massachusetts); Uri Blumenthal (Westford, Massachusetts); Benjamin Woodbury Fuller (Mansfield, Connecticut); Robert Kevin Cunningham (Lexington, Massachusetts) |
| ABSTRACT | An aspect of authenticating a user via a processing system includes receiving, at an input device of the processing system, an input gesture corresponding to an explicit assertion of user intent with respect to a function to be performed on the processing system; and simultaneously authorizing and authenticating the user, with respect to the function, from data acquired from the input gesture. |
| FILED | Monday, August 06, 2018 |
| APPL NO | 16/055779 |
| ART UNIT | 2495 — Cryptography and Security |
| CURRENT CPC | Electric Digital Data Processing G06F 3/041 (20130101) G06F 3/03543 (20130101) G06F 3/04883 (20130101) G06F 21/32 (20130101) Original (OR) Class G06F 2203/0336 (20130101) Image or Video Recognition or Understanding G06V 40/1365 (20220101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/3247 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11449788 | Perona et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Pietro Perona (Pasadena, California); Grant Van Horn (Pasadena, California); Steven J. Branson (Pasadena, California) |
| ABSTRACT | Systems and methods for the annotation of source data in accordance with embodiments of the invention are disclosed. In one embodiment, a data annotation server system obtains a set of source data, provides at least one subset of source data to at least one annotator device, obtains a set of annotation data from the at least one annotator device for each subset of source data, classifies the source data based on the annotation data using a machine classifier for each subset of source data, generates annotator model data describing the characteristics of the at least one annotator device, and generates source data model data describing at least one piece of source data in the set of source data, where the source data model data includes label data identifying the estimated ground truth for each piece of source data in the set of source data. |
| FILED | Monday, March 19, 2018 |
| APPL NO | 15/925417 |
| ART UNIT | 2129 — AI & Simulation/Modeling |
| CURRENT CPC | Electric Digital Data Processing G06F 16/48 (20190101) G06F 16/285 (20190101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 3/0445 (20130101) G06N 3/0454 (20130101) G06N 3/0472 (20130101) G06N 3/0481 (20130101) G06N 5/003 (20130101) G06N 5/022 (20130101) G06N 7/005 (20130101) G06N 20/00 (20190101) Original (OR) Class G06N 20/10 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11450064 | Michael et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Nathan Michael (Pittsburgh, Pennsylvania); Shobhit Srivastava (San Diego, California) |
| ABSTRACT | A system and method to generate perceptual models of the environment that optimally handle the variation in clutter and provide a multiresolution and multi-fidelity representation of the environment is described. The system and method is able to capture inherent structural dependencies, thereby allowing efficient and precise inferences to be drawn. The approach employs a hierarchy of Gaussian Mixtures to approximate the underlying spatial distribution. |
| FILED | Thursday, August 31, 2017 |
| APPL NO | 16/330411 |
| ART UNIT | 2616 — Computer Graphic Processing, 3D Animation, Display Color Attribute, Object Processing, Hardware and Memory |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6215 (20130101) G06K 9/6288 (20130101) Computer Systems Based on Specific Computational Models G06N 7/005 (20130101) Image Data Processing or Generation, in General G06T 17/20 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11450214 | Trent et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Architecture Technology Corporation (Eden Prairie, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Barry A. Trent (Chanhassen, Minnesota); Ranga S. Ramanujan (Medina, Minnesota); Fabio F. Pozzo (Minneapolis, Minnesota) |
| ABSTRACT | A method of generating a flight path for an aircraft is provided. The method includes modeling geographic space and time that includes a plurality of mobile communication nodes. The model includes locations of each of the plurality of mobile communication nodes as those nodes move over time. The model also provides an indication of wireless connectivity between a radio on each of the plurality of communication nodes and a radio of the aircraft at their respective location. The method further includes running a plurality of flight paths through the model in order to identify a selected flight path that provides a desired level of connectivity between the aircraft and the plurality of communication nodes. |
| FILED | Tuesday, November 12, 2019 |
| APPL NO | 16/681242 |
| ART UNIT | 3666 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/20 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/0022 (20130101) G05D 1/104 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/047 (20130101) Traffic Control Systems G08G 5/0013 (20130101) G08G 5/0026 (20130101) G08G 5/0034 (20130101) Original (OR) Class G08G 5/0039 (20130101) G08G 5/0043 (20130101) G08G 5/0086 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11450500 | Albrecht |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Nicholas H. Albrecht (Ridgecrest, California) |
| ABSTRACT | Shock resistant mounting structures for fuze systems. The shock resistant mounting structures may comprise: a shock resistant fuze cap and a shock resistant collar. The shock resistant fuze cap may comprise a circular cap housing and a plurality of cripple studs disposed within the circular cap housing. The circular cap housing may be adapted to engage an upper portion of a fuze and may be adapted to snugly fit within a fuze well. The shock resistant collar may comprise a ring-shaped housing and one or more cripple studs radially disposed within the ring-shaped housing. The ring-shaped housing may have a center opening adapted to engage a fuze body. When installed, the shock resistant fuze cap and shock resistant collar may be disposed within the fuze well and may minimize, prevent, or divert shock loading energy from entering a fuze. |
| FILED | Thursday, August 19, 2021 |
| APPL NO | 17/406450 |
| ART UNIT | 3641 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 39/24 (20130101) Ammunition Fuzes; Arming or Safety Means Therefor F42C 19/02 (20130101) F42C 19/04 (20130101) Electric Switches; Relays; Selectors; Emergency Protective Devices H01H 85/0017 (20130101) H01H 85/175 (20130101) Original (OR) Class H01H 85/2045 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11451189 | Foos et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America As Represented by the Secretary of the Navy (Indian Head, Maryland) |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Edward E. Foos (Alexandria, Virginia); Richard Jason Jouet (Alexandria, Virginia) |
| ABSTRACT | The method of the present invention improves mechanical integrity of a crystalline silicon solar cell having an exposed layer of n-type silicon. A solution of electrically-conductive nanowires in an inert liquid is sprayed onto the exposed layer in order to form a grid pattern of the nanowires on the exposed layer after the inert liquid dries or evaporates. |
| FILED | Friday, February 16, 2018 |
| APPL NO | 15/932203 |
| ART UNIT | 2894 — Semiconductors/Memory |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/0216 (20130101) H01L 31/1804 (20130101) H01L 31/022433 (20130101) Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 30/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11451231 | Jiang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | Yale University (New Haven, Connecticut) |
| INVENTOR(S) | Liang Jiang (Guilford, Connecticut); Steven M. Girvin (Hamden, Connecticut); Brian Lester (New Haven, Connecticut); Yvonne Gao (Singapore, Singapore); Robert J. Schoelkopf, III (Madison, Connecticut) |
| ABSTRACT | Techniques for implementing robust quantum logic gates are provided and described. In some aspects, a quantum logic gate between a plurality of cavities comprising a first cavity and a second cavity is implemented by performing a first beam splitter operation between the first cavity and the second cavity using a coupling transmon that is dispersively coupled to both the first cavity and the second cavity, and performing a controlled phase shift operation between the second cavity and an ancilla transmon that is dispersively coupled to the second cavity but not dispersively coupled to the first cavity. |
| FILED | Saturday, January 05, 2019 |
| APPL NO | 16/959184 |
| ART UNIT | 2842 — Electrical Circuits and Systems |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 5/18 (20130101) Pulse Technique H03K 19/195 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 11446741 | Demuth et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| INVENTOR(S) | James A. Demuth (Mountain View, California); Andrew J. Bayramian (Manteca, California); Bassem S. El-Dasher (Livermore, California); Kevin J. Kramer (Redmond, Washington) |
| ABSTRACT | A method is disclosed for manufacturing a part via an additive manufacturing process. A solution is used which has a volatile component within which is suspended particles of a powdered material. The solution is heated until it at least one of begins boiling or is about to begin boiling. The heated solution is then deposited at least at one location on a substrate to help form a layer of the part. The volatile component then evaporates, leaving only the particles of powdered material. The particles are then heated to the melting point. The deposition and heating operations are repeated to successively form a plurality of layers for the part. The evaporation of the volatile component helps to cool the part. |
| FILED | Monday, August 10, 2020 |
| APPL NO | 16/989463 |
| ART UNIT | 1733 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/107 (20220101) B22F 10/10 (20210101) B22F 12/00 (20210101) Original (OR) Class Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/153 (20170801) B29C 64/165 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 10/25 (20151101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11446915 | Biswas et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | UT-BATTELLE, LLC (Oak Ridge, Tennessee) |
| INVENTOR(S) | Kaushik Biswas (Oak Ridge, Tennessee); David Lee Wood, III (Oak Ridge, Tennessee); Kelsey M. Grady (Oak Ridge, Tennessee); Natasha B. Ghezawi (Oak Ridge, Tennessee); Pengfei Cao (Oak Ridge, Tennessee); Tomonori Saito (Oak Ridge, Tennessee) |
| ABSTRACT | An improved method for manufacturing a continuous self-healing barrier film is provided. The method includes slot-die coating opposing sides of a separator substrate with a curing agent slurry and a curable resin slurry using a single-sided coating line or a tandem coating line. The method also includes sequentially interleaving inner and outer protective layers via a continuous roll-to-roll process to create a multi-layered barrier film. The barrier film can optionally be formed into a barrier envelope, and an insulating core material can be inserted into the barrier envelope to define an enclosure. Evacuating and sealing the enclosure along a perimeter of the barrier envelop forms a self-healing vacuum insulation panel with excellent properties for use as a building material and in refrigeration systems, for example. The barrier film can alternatively be used in the manufacture of tires, roofing, cargo containers, food packaging, and pharmaceutical packaging, for example. |
| FILED | Monday, June 08, 2020 |
| APPL NO | 16/895006 |
| ART UNIT | 1746 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 73/22 (20130101) Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 37/153 (20130101) Original (OR) Class B32B 2038/168 (20130101) B32B 2305/77 (20130101) B32B 2307/304 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447405 | Gao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
| ASSIGNEE(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
| INVENTOR(S) | Xin Gao (Lexington, Kentucky); Kunlei Liu (Lexington, Kentucky); James R. Landon (Lexington, Kentucky); Jesse Thompson (Lexington, Kentucky); Ayokunle O. Omosebi (Lexington, Kentucky); Keemia Abad (Lexington, Kentucky); Zilong Ma (Xuzhou, China PRC) |
| ABSTRACT | A method and apparatus are provided for removing EPA regulated chemical species from industrial wastewater using green rust. The apparatus includes a green rust generator having an iron anode and a carbon cathode. |
| FILED | Friday, May 15, 2020 |
| APPL NO | 16/875169 |
| ART UNIT | 1777 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/385 (20130101) C02F 1/463 (20130101) Original (OR) Class C02F 1/4674 (20130101) C02F 1/5263 (20130101) C02F 1/46109 (20130101) C02F 2001/46133 (20130101) C02F 2101/103 (20130101) C02F 2101/106 (20130101) C02F 2101/163 (20130101) C02F 2101/166 (20130101) C02F 2201/4619 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447433 | Sofranko et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | EcoCatalytic Inc. (Woburn, Massachusetts) |
| ASSIGNEE(S) | EcoCatalytic Inc. (Weston, Massachusetts) |
| INVENTOR(S) | John A. Sofranko (Weston, Massachusetts); Royce Macwan (Woburn, Massachusetts); Elena Y. Chung (Somerville, Massachusetts); C. Andrew Jones (Newtown Square, Pennsylvania) |
| ABSTRACT | Enhanced oxygen transfer agent systems and methods of use thereof are provided. According to one aspect, a method for producing olefins from a hydrocarbon feed includes the step of contacting a hydrocarbon feed comprised of one or more alkanes with an oxygen transfer agent at a temperature of 350° C. to 1000° C. The oxygen transfer agent includes an oxygen-donating chalcogen agent including at least one of S, Se, or Te and a reducible metal oxide. The chalcogen has an oxidation state greater than +2. A method for producing one or more olefins by partial combustion of a hydrocarbon feed is provided. The method includes partially combusting a hydrocarbon feed comprised of one or more alkanes by contacting the hydrocarbon feed with an oxygen transfer agent comprising CaSO4 at a temperature of 350° C. to 1000° C. to produce one or more olefins comprising ethylene and coproducing water. |
| FILED | Monday, January 11, 2021 |
| APPL NO | 17/145587 |
| ART UNIT | 1772 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 27/055 (20130101) B01J 35/002 (20130101) Acyclic or Carbocyclic Compounds C07C 2/84 (20130101) C07C 5/46 (20130101) Original (OR) Class C07C 11/04 (20130101) C07C 2521/10 (20130101) C07C 2523/04 (20130101) C07C 2523/34 (20130101) C07C 2527/053 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447754 | Donohue et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Timothy James Donohue (Middleton, Wisconsin); Daniel Leo Gall (Madison, Wisconsin); Wayne S. Kontur (Madison, Wisconsin); Hoon Kim (Madison, Wisconsin); John Ralph (Madison, Wisconsin); Daniel R. Noguera (Madison, Wisconsin); Brian Fox (Madison, Wisconsin); Craig Bingman (Fitchburg, Wisconsin) |
| ABSTRACT | Enzymes for depolymerizing lignin. The enzymes include dehydrogenases, β-etherases, and glutathione lyases. The dehydrogenases can comprise one or more or LigD, LigO, LigN, and LigL. The β-etherases can comprise one or more of LigE, LigF, LigP, and BaeA. The glutathione lyases can comprise any one or more of LigG and a number of non-stereospecific, optionally recombinant glutathione lyases derived from Sphingobium sp. SYK-6, Novosphingobium aromaticivorans, Escherichia coli, Streptococcus sanguinis, Phanerochaete chrysosporium, and other microorganisms. The enzymes can be combined in compositions and/or used in methods of processing lignin or other aromatic compounds in vitro. |
| FILED | Wednesday, September 30, 2020 |
| APPL NO | 17/038971 |
| ART UNIT | 1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/88 (20130101) C12N 9/1088 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/22 (20130101) C12P 7/26 (20130101) Enzymes C12Y 114/16005 (20130101) C12Y 205/01018 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447809 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David R. Liu (Lexington, Massachusetts); David Irby Bryson, Jr. (Dorchester, Massachusetts) |
| ABSTRACT | The disclosure provides amino acid sequence variants of orthogonal aminoacyl-tRNA synthetases (AARSs) having increased activity and selectivity compared to previous AARSs, and methods of producing the same. |
| FILED | Tuesday, July 03, 2018 |
| APPL NO | 16/628456 |
| ART UNIT | 1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/93 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/02 (20130101) Original (OR) Class Enzymes C12Y 601/01026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447862 | Mane et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UChicago Argonne, LLC (Chicago, Illinois); Boise State University (Boise, Idaho) |
| INVENTOR(S) | Anil U. Mane (Naperville, Illinois); Jeffrey W. Elam (Elmhurst, Illinois); Steven Letourneau (Naperville, Illinois); Elton Graugnard (Boise, Idaho) |
| ABSTRACT | Transition metal dichalcogenides (TMDs) are deposited as thin layers on a substrate. The TMDs may be grown on oxide substrates and may have a tunable TMD-oxide interface. |
| FILED | Wednesday, March 06, 2019 |
| APPL NO | 16/294838 |
| ART UNIT | 1715 — Coating, Etching, Cleaning, Single Crystal Growth |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/08 (20130101) C23C 16/305 (20130101) C23C 16/45527 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447882 | Ren et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Houston System (Houston, Texas) |
| ASSIGNEE(S) | UNIVERSITY OF HOUSTON SYSTEM (Houston, Texas) |
| INVENTOR(S) | Zhifeng Ren (Pearland, Texas); Fang Yu (Houston, Texas); Haiqing Zhou (Houston, Texas); Shuo Chen (Houston, Texas) |
| ABSTRACT | A method of manufacturing a bifunctional electrocatalyst for overall water splitting comprising oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) by growing electrocatalyst comprising primarily metallic phosphides on a three-dimensional substrate by: immersing the substrate in an iron nitrate solution to form a once disposed substrate; subjecting the once disposed substrate to thermal phosphidation with phosphorus powder under inert gas to grow metal phosphides thereupon and form a once subjected substrate; cooling the once subjected substrate to form a cooled, once subjected substrate; immersing the cooled, once subjected substrate in an iron nitrate solution to form a twice disposed substrate; and subjecting the twice disposed substrate to thermal phosphidation with phosphorus powder under inert gas to provide an electrode comprising the bifunctional electrocatalyst on the three-dimensional substrate. |
| FILED | Wednesday, April 10, 2019 |
| APPL NO | 17/047032 |
| ART UNIT | 1715 — Coating, Etching, Cleaning, Single Crystal Growth |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/18 (20130101) C23C 16/30 (20130101) C23C 16/045 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/04 (20130101) C25B 11/061 (20210101) C25B 11/075 (20210101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11448549 | Jordan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Rochester (Rochester, New York); Consiglio Nazionale delle Ricerche CNR (Rome, Italy) |
| ASSIGNEE(S) | University of Rochester (Rochester, New York); Consiglio Nazionale delle Ricerche CNR (Rome, Italy) |
| INVENTOR(S) | Andrew N. Jordan (Rochester, New York); Francesco Giazotto (Pisa, Italy); Sreenath K. Manikandan (Rochester, New York) |
| ABSTRACT | A heat transfer device and method are disclosed. The device includes a working region (i.e., working substance) made from a first superconducting material having a superconducting state and a normal state when magnetized. The first superconducting material has a first energy gap while in the superconducting state. A substrate (i.e., cold reservoir) is connected to the working region at a first tunnel junction. The substrate may be a metallic substrate. A heat sink (i.e., hot reservoir) is connected to the working region at a second tunnel junction. The heat sink is made from a second superconducting material having a second energy gap that is larger than the first energy gap. In a particular example, the heat transfer device includes a metallic substrate is made from Copper, a working region made from Tantalum, a heat sink made from Niobium, and the first and second tunnel junctions are made from Tantalum Oxide. |
| FILED | Friday, October 04, 2019 |
| APPL NO | 16/593781 |
| ART UNIT | 1735 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 1/42 (20130101) Original (OR) Class G01J 1/0252 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 39/10 (20130101) H01L 39/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11448555 | Bora |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| INVENTOR(S) | Mihail Bora (Livermore, California) |
| ABSTRACT | Exemplary systems for detecting water include: a light source positioned to transmit thermal radiation through a sample; a lens assembly positioned to: receive the thermal radiation transmitted through the sample; and focus the transmitted thermal radiation onto a filter positioned between the lens assembly and a detector; and a cooling subsystem for cooling the filter and the detector to a temperature below that of the sample. Methods for detecting presence of water in a sample are also disclosed. |
| FILED | Tuesday, November 24, 2020 |
| APPL NO | 17/103670 |
| ART UNIT | 2855 — Printing/Measuring and Testing |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 5/0037 (20130101) G01J 5/0806 (20130101) G01J 5/0896 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11448749 | Judd et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Triad National Security, LLC (Los Alamos, New Mexico) |
| ASSIGNEE(S) | Triad National Security, LLC (Los Alamos, New Mexico) |
| INVENTOR(S) | Stephen Judd (Los Alamos, New Mexico); David Guenther (Los Alamos, New Mexico); Nicholas Dallmann (Los Alamos, New Mexico); William Mairson (Los Alamos, New Mexico) |
| ABSTRACT | A tag enhances vehicle radar visibility of objects by increasing the effective radar cross-section of the object, allowing detection at longer ranges and providing the vehicle/driver with more time to avoid a collision. The tag may include a receive antenna and a bandpass filter configured to receive a signal from the receive antenna and to allow a portion of the frequency range of the signal from the receive antenna through. The tag may also include an amplifier configured to receive and amplify the signal with the portion of the frequency range from the bandpass filter. The tag may further include a transmit antenna configured to transmit the amplified signal. The receive antenna, the transmit antenna, and the amplifier may be configured such that antenna-to-antenna isolation between the receive antenna and the transmit antenna is greater than a gain of the amplifier. |
| FILED | Tuesday, September 11, 2018 |
| APPL NO | 16/128123 |
| ART UNIT | 3646 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 13/767 (20130101) Original (OR) Class G01S 13/931 (20130101) Antennas, i.e Radio Aerials H01Q 1/273 (20130101) H01Q 1/525 (20130101) H01Q 1/3233 (20130101) H01Q 9/0407 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11448792 | Barajas-Olalde et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Energy and Environmental Research Center Foundation (Grand Forks, North Dakota) |
| ASSIGNEE(S) | Energy and Environmental Research Center Foundation (Grand Forks, North Dakota) |
| INVENTOR(S) | César Barajas-Olalde (Tampico, Mexico); Kyle A. Glazewski (Grand Forks, North Dakota); Nicholas W. Bosshart (Larimore, North Dakota) |
| ABSTRACT | Methods are presented for determining the location of underground features (e.g., CO2). One method includes capturing, by sensors distributed throughout a region, seismic traces associated with seismic signals generated by a seismic source. For multiple sensors, active noise is identified or passive noise is measured within each seismic trace and values for attributes associated with the active or passive noise are determined. Further, an unsupervised machine-learning model, based on the values of the attributes, is utilized to determine noise characteristics for multiple sensors. The sensors are grouped in clusters based on the noise characteristics for each sensor. For multiple clusters, a noise filter is created based on the noise characteristics of the sensors in the cluster, and the noise filter of the cluster is applied, for multiple sensors, to the seismic traces of the sensor. Additionally, the filtered seismic traces are analyzed to determine a location of CO2 underground. |
| FILED | Wednesday, December 09, 2020 |
| APPL NO | 17/116409 |
| ART UNIT | 2864 — Printing/Measuring and Testing |
| CURRENT CPC | Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags G01V 1/288 (20130101) G01V 1/301 (20130101) G01V 1/364 (20130101) Original (OR) Class G01V 2210/3246 (20130101) G01V 2210/3248 (20130101) Computer Systems Based on Specific Computational Models G06N 5/04 (20130101) G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11450802 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| INVENTOR(S) | Yiyang Li (Newark, California); Albert Alec Talin (Dublin, California); Elliot James Fuller (Dublin, California) |
| ABSTRACT | A thermally sensitive ionic redox transistor comprises a solid channel, a solid reservoir layer, and a solid electrolyte layer disposed between the channel and the reservoir layer. A conductance of the channel is varied by changing the concentration of ions such as oxygen vacancies in the channel layer. Ionic conductivity of the gate, electrolyte, and channel layers increase with increasing temperature. Ion or vacancy transport between the channel and the reservoir layer across the electrolyte layer occurs in response to applying a voltage between the channel and the reservoir layer when the device is heated to an elevated temperature. When the device is cooled below the elevated temperature, the ions are trapped in one or more of the layers because the materials lose their ionic conductivity. A state of the redox transistor can be read by measuring the conductance of the channel. |
| FILED | Tuesday, April 21, 2020 |
| APPL NO | 16/854151 |
| ART UNIT | 2825 — Semiconductors/Memory |
| CURRENT CPC | Static Stores G11C 13/004 (20130101) G11C 13/0011 (20130101) G11C 2013/0045 (20130101) G11C 2213/53 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 45/085 (20130101) H01L 45/146 (20130101) H01L 45/147 (20130101) H01L 45/1206 (20130101) Original (OR) Class H01L 45/1266 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11450860 | Radacsi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (, None) |
| INVENTOR(S) | Norbert Radacsi (Pasadena, California); Konstantinos P. Giapis (Pasadena, California) |
| ABSTRACT | Nanostructured materials, and methods and apparatus for their production are provided. Nanostructured materials comprise nanofibers having nanoparticles deposited along the outer surface thereof. The size of the nanofibers and nanoparticles, and the spacing of such nanoparticles along the nanofibers may be controlled over a wide range. Nanostructured materials may comprise a plurality of such nanofibers interwoven together to form fiber cloth-like materials. Many materials may be used to form the nanofibers including polymer nanofiber materials (e.g., polyvinyl alcohol (PVA) polyvinylpyrrolidone (PVP), etc.) along with compatible nanoparticle materials (e.g., salts or other crystallizable materials). |
| FILED | Wednesday, June 14, 2017 |
| APPL NO | 15/623220 |
| ART UNIT | 1723 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) B82Y 40/00 (20130101) Compositions of Macromolecular Compounds C08L 57/10 (20130101) C08L 71/00 (20130101) C08L 2203/20 (20130101) C08L 2205/16 (20130101) Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/003 (20130101) D01D 5/0076 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 1/10 (20130101) Treatment, Not Provided for Elsewhere in Class D06, of Fibres, Threads, Yarns, Fabrics, Feathers or Fibrous Goods Made From Such Materials D06M 11/00 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/88 (20130101) H01M 4/665 (20130101) H01M 4/666 (20130101) H01M 4/8647 (20130101) H01M 4/8652 (20130101) H01M 4/8663 (20130101) Original (OR) Class H01M 4/8803 (20130101) H01M 4/8842 (20130101) H01M 4/9075 (20130101) H01M 8/086 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 70/50 (20151101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11450970 | Kamali et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| INVENTOR(S) | Seyedeh Mahsa Kamali (Arcadia, California); Ehsan Arbabi (Arcadia, California); Andrei Faraon (La Canada Flintridge, California) |
| ABSTRACT | Cascaded metasurfaces can control the phase, amplitude and polarization of an electromagnetic beam, shaping it in three dimensional configuration not achievable with other methods. Each cascaded metasurface has dielectric or metallic scatterers arranged in a period array. The shape of the scatterers determines the three dimensional configuration of the output beam and is determined with iterative calculations through computational simulations. |
| FILED | Tuesday, December 04, 2018 |
| APPL NO | 16/209788 |
| ART UNIT | 2872 — Optics |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 1/002 (20130101) G02B 5/3083 (20130101) G02B 27/0012 (20130101) G02B 27/44 (20130101) G02B 27/0944 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/00 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/70408 (20130101) Antennas, i.e Radio Aerials H01Q 1/422 (20130101) H01Q 1/425 (20130101) H01Q 15/242 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11450992 | Trenbath et al. |
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| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| INVENTOR(S) | Thien-Kim Leckie Trenbath (Boulder, Colorado); William Cook Livingood, III (Lakewood, Colorado); Amy LeBar (Golden, Colorado); Bennett R. Doherty (Bedford, New Hampshire) |
| ABSTRACT | The present disclosure relates to a plug load management system having automatic and dynamic load detection, meaning it has the ability to identify devices that are plugged into outlets of a building and determine the location of the plug load down to the specific outlet. When a device is moved, the plug load management system can determine this change and update accordingly. |
| FILED | Thursday, March 11, 2021 |
| APPL NO | 17/198721 |
| ART UNIT | 2833 — Electrical Circuits and Systems |
| CURRENT CPC | Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors H01R 13/6683 (20130101) H01R 13/6691 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11451004 | McIntyre et al. |
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| FUNDED BY |
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| APPLICANT(S) | United States Department of Energy (Washington, District of Columbia) |
| ASSIGNEE(S) | U.S. Department of Energy (Washington, District of Columbia) |
| INVENTOR(S) | Dustin McIntyre (Washington, Pennsylvania); Daniel Hartzler (Westover, West Virginia) |
| ABSTRACT | One or more embodiments relates to a method of growing ultrasmooth and high quantum efficiency CsTe photocathodes. The method includes exposing a substrate of Cs using an alkali source such as an effusion cell; and controlling co-evaporating growth and co-deposition forming a CsTe growth. The method further includes monitoring a stoichiometry of the CsTe growth. |
| FILED | Monday, October 19, 2020 |
| APPL NO | 17/074162 |
| ART UNIT | 2886 — Optics |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/31 (20130101) G01N 2201/08 (20130101) G01N 2201/0633 (20130101) G01N 2201/0634 (20130101) G01N 2201/0636 (20130101) G01N 2201/06113 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/11 (20130101) H01S 3/106 (20130101) Original (OR) Class H01S 3/094038 (20130101) H01S 3/094053 (20130101) H01S 3/094096 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11451061 | Radhakrishnan et al. |
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| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Nikitha Radhakrishnan (Richland, Washington); Jacob Hansen (Seattle, Washington); Saptarshi Bhattacharya (Richland, Washington); Kevin P. Schneider (Seattle, Washington); Bishnu P. Bhattarai (Kennewick, Washington); Wei Du (Richland, Washington); Md Jan E Alam (Richland, Washington); Abhishek Somani (Richland, Washington) |
| ABSTRACT | Apparatus and methods are disclosed for restoring operation of a power grid comprising a plurality of reclosers and distributed energy resources (DERs) responsive to abnormal conditions by determining and implementing a reconfiguration for the power grid. The reconfiguration can specify respective new statuses for one or more of the reclosers and/or respective quantities of reactive power to be supplied by one or more of the DERs. The reconfiguration can be determined based on a plurality of constraints using an objective function, the constraints being determined based at least in part on recloser status data and/or DER power generation capability data. Respective cleared quantities of reactive power for the DERs to supply to the reconfigured power grid can be determined via a transactive control scheme, and the reconfiguration can be updated prior to implementation based on the results of the transactive control scheme. |
| FILED | Monday, November 04, 2019 |
| APPL NO | 16/673781 |
| ART UNIT | 2115 — Computer Error Control, Reliability, & Control Systems |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 15/02 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/18 (20130101) H02J 3/381 (20130101) Original (OR) Class H02J 13/0017 (20130101) H02J 2203/20 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11451093 | Lin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesville, Florida) |
| INVENTOR(S) | Jenshan Lin (Gainesville, Florida); Lawrence Fomundam (Hyattsville, Maryland) |
| ABSTRACT | Various examples are provided for wireless power transfer to implants. In one example, a system includes a radio frequency (RF) power source and a transmitter (TX) array comprising an excitation coil and resonant coils distributed about the excitation coil. The TX array can transfer power from the RF power source to a biomedical implant inserted below a skin surface of a subject when the TX array is positioned on the skin surface adjacent to the biomedical implant. A receiver (RX) coil of the biomedical implant can inductively couple with the TX array for the power. The resonant coils can allow power transfer when the RX coil is not aligned with the excitation coil. |
| FILED | Wednesday, September 05, 2018 |
| APPL NO | 16/644863 |
| ART UNIT | 2842 — Electrical Circuits and Systems |
| CURRENT CPC | Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 38/14 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 50/12 (20160201) Original (OR) Class H02J 50/20 (20160201) H02J 50/402 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11451383 | Bush |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | GENERAL ELECTRIC COMPANY (Schenectady, New York) |
| INVENTOR(S) | Stephen Francis Bush (Latham, New York) |
| ABSTRACT | A communication system is provided that includes a first quantum key distribution device and a communication device. The first quantum key distribution device is configured to be coupled to a second quantum key distribution device over a quantum channel and to generate a quantum key based on a quantum state transmitted along the quantum channel. The communication device is communicatively connected to the first quantum key distribution device within a network. The communication device is configured to receive the quantum key from the first quantum key distribution device and transmit the quantum key to an end device in the network via a classical link to enable the end device to use the quantum key for encrypting and/or decrypting messages communicated through the network. |
| FILED | Thursday, September 12, 2019 |
| APPL NO | 16/569491 |
| ART UNIT | 2495 — Cryptography and Security |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/088 (20130101) H04L 9/0819 (20130101) H04L 9/0852 (20130101) Original (OR) Class H04L 2209/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 11445976 | Ganesan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | University of Massachusetts (Boston, Massachusetts) |
| INVENTOR(S) | Deepak Ganesan (Amherst, Massachusetts); Trisha L. Andrew (Hadley, Massachusetts); Ali Kiaghadi (Amherst, Massachusetts); Seyedeh Zohreh Homayounfar (Amherst, Massachusetts); Jeremy Gummeson (Belchertown, Massachusetts) |
| ABSTRACT | A garment system comprises a garment substrate formed from one or more textile-based sheets, a distributed array of a plurality of resistive pressure sensors coupled to the garment substrate at a set of first specified locations. Each of the plurality of resistive sensors comprises a pair of first textile-based outer layers each having an electrical resistance of no more than 100 ohms and a textile-based inner layer sandwiched between the pair of first textile-based outer layers having an electrical resistance of at least 1 mega-ohm. The system also includes electronics configured to process signals from the distributed array of resistive pressure sensors to determine one or more physiological properties of a wearer of the garment substrate. |
| FILED | Tuesday, March 31, 2020 |
| APPL NO | 17/593940 |
| ART UNIT | 1786 — Miscellaneous Articles, Stock Material |
| CURRENT CPC | Outerwear; Protective Garments; Accessories A41D 1/005 (20130101) A41D 31/04 (20190201) Diagnosis; Surgery; Identification A61B 5/1102 (20130101) A61B 5/1116 (20130101) A61B 5/6804 (20130101) Original (OR) Class A61B 5/6823 (20130101) A61B 2562/0247 (20130101) Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 3/08 (20130101) B32B 5/024 (20130101) B32B 5/26 (20130101) B32B 7/025 (20190101) B32B 2250/20 (20130101) B32B 2255/02 (20130101) B32B 2255/26 (20130101) B32B 2255/205 (20130101) B32B 2262/062 (20130101) B32B 2262/0261 (20130101) B32B 2307/73 (20130101) B32B 2307/202 (20130101) B32B 2307/204 (20130101) B32B 2307/206 (20130101) B32B 2437/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11446887 | Jethmalani et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Novol, Inc. (San Leandro, California) |
| ASSIGNEE(S) | NOVOL, INC. (San Leandro, California) |
| INVENTOR(S) | Jagdish Jethmalani (San Leandro, California); Sanjiban Chakraborty (San Leandro, California); Monica Bhatia (San Leandro, California) |
| ABSTRACT | Provided herein are methods of molding thermoplastic polymers into optical elements. The optical elements in the form of cylindrical discs, semi-finished lens blanks or finished lenses are compression molded at high temperature typically above thermoplastic polymers softening temperature and under high pressure. The semi-finished lens blanks and finished lenses are molded using front and back glass molds inside a mold assembly which reshapes the cylindrical discs that are either previously molded or cut out from thick slab. Also provided are methods for producing single vision and progressive addition lens prescriptions. |
| FILED | Monday, October 26, 2020 |
| APPL NO | 17/080380 |
| ART UNIT | 1742 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 51/30 (20130101) Producing Particular Articles From Plastics or From Substances in a Plastic State B29D 11/0049 (20130101) Original (OR) Class B29D 11/00413 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2033/12 (20130101) B29K 2067/00 (20130101) B29K 2069/00 (20130101) B29K 2075/00 (20130101) B29K 2077/00 (20130101) B29K 2909/08 (20130101) Optical Elements, Systems, or Apparatus G02B 1/041 (20130101) Spectacles; Sunglasses or Goggles Insofar as They Have the Same Features as Spectacles; Contact Lenses G02C 7/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447508 | Waldmann et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasenda, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California); The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Christopher Martin Waldmann (Santa Monica, California); Anton A. Toutov (Pasadena, California); Jennifer Marie Murphy (Los Angeles, California); Robert H. Grubbs (South Pasadena, California) |
| ABSTRACT | The present disclosure sets forth novel compounds and compositions including heteroaromatic silicon-fluoride-acceptors, which are useful for PET scanning. The present disclosure further includes novel methods of 18F imaging for PET scanning, the methods comprising the preparation of conjugates and bioconjugates of biological ligands of interest with heteroaromatic silicon-fluoride-acceptors. In certain embodiments the invention is practiced in the form of a kit. |
| FILED | Wednesday, August 19, 2020 |
| APPL NO | 16/997240 |
| ART UNIT | 1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/1027 (20130101) A61K 51/1072 (20130101) General Methods of Organic Chemistry; Apparatus Therefor C07B 59/004 (20130101) C07B 2200/05 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447734 | Reiserer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| INVENTOR(S) | Ronald S. Reiserer (Nashville, Tennessee); Gregory B. Gerken (Nashville, Tennessee); David K. Schaffer (Nashville, Tennessee); John P. Wikswo (Brentwood, Tennessee) |
| ABSTRACT | A continuous automated perfusion culture analysis system (CAPCAS) comprises one or more fluidic systems configured to operate large numbers of biodevices in parallel. Each fluidic system comprises an input reservoir plate for receiving media; a biodevice plate comprising an array of biodevices fluidically coupled to the input reservoir plate, configured such that each biodevice has independent media delivery, fluid removal, stirring, and gas control, and each biodevice is capable of continuously receiving the media from the input reservoir plate; and an output plate fluidically coupled to the biodevice plate for real-time analysis and sampling. The operations of the CAPCAS are automated and computer-controlled wirelessly. The CAPCAS can also be used for abiotic and biotic chemical synthesis processes. |
| FILED | Wednesday, January 19, 2022 |
| APPL NO | 17/578966 |
| ART UNIT | 1799 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/08 (20130101) C12M 23/10 (20130101) C12M 23/12 (20130101) C12M 23/16 (20130101) C12M 23/50 (20130101) C12M 23/58 (20130101) C12M 27/02 (20130101) C12M 27/12 (20130101) C12M 29/10 (20130101) Original (OR) Class C12M 35/02 (20130101) C12M 35/04 (20130101) C12M 41/48 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447807 | Church et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | George M. Church (Brookline, Massachusetts); Evan R. Daugharthy (Cambridge, Massachusetts); Richard C. Terry (Carlisle, Massachusetts) |
| ABSTRACT | The present disclosure provides methods that combine RNA fluorescent in situ sequencing (FISSEQ) with other molecular detection modalities, forming an integrated panomic detection platform. In various embodiments, the present disclosure provides systems and methods to prepare a biological sample to preserve the spatial relationships of biomolecules of interest within the biological sample for FISSEQ detection. |
| FILED | Thursday, February 28, 2019 |
| APPL NO | 16/288200 |
| ART UNIT | 1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/50 (20130101) A61L 2400/16 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 2300/0636 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1093 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/682 (20130101) C12Q 1/6834 (20130101) C12Q 1/6874 (20130101) C12Q 1/6874 (20130101) C12Q 2543/10 (20130101) C12Q 2563/107 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6842 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447824 | Doudna et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Jennifer A. Doudna (Berkeley, California); Janice S. Chen (Berkeley, California); Lucas Benjamin Harrington (Berkeley, California); Enbo Ma (Moraga, California) |
| ABSTRACT | Provided are compositions and methods for detecting a target DNA (double stranded or single stranded) in a sample. In some embodiments, a subject method includes: (a) contacting the sample with: (i) a type V CRISPR/Cas effector protein (e.g., a Cas12 protein such as Cas12a, Cas12b, Cas12c, Cas12d, Cas12e); (ii) a guide RNA (comprising a region that binds to the type V CRISPR/Cas effector protein, and a guide sequence that hybridizes with the target DNA); and (iii) a detector DNA that is single stranded (i.e., a “single stranded detector DNA”) and does not hybridize with the guide sequence of the guide RNA; and (b) measuring a detectable signal produced by cleavage (by the type V CRISPR/Cas effector protein) of the single stranded detector DNA. Also provided are compositions and methods for cleaving single stranded DNAs (e.g., non-target ssDNAs), e.g., inside of a cell. |
| FILED | Monday, July 13, 2020 |
| APPL NO | 16/927351 |
| ART UNIT | 1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 2310/20 (20170501) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6823 (20130101) C12Q 1/6823 (20130101) C12Q 1/6876 (20130101) Original (OR) Class C12Q 2521/301 (20130101) C12Q 2521/543 (20130101) C12Q 2522/101 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11448630 | Urschel et al. |
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| FUNDED BY |
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| APPLICANT(S) | RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew R. Urschel (Troy, New York); Andrew Turk (Troy, New York); Tessa Hilary Pocock (Troy, New York) |
| ABSTRACT | An apparatus for remote detection of plant growth dynamics is described. The apparatus includes an excitation LED (light emitting diode) module, a detection module and a controller module coupled to the excitation LED module and the detection module. The excitation LED module includes at least one LED. Each LED is configured to emit an excitation light in response to an excitation control signal. The excitation light has an emitted light spectrum. The detection module includes a photodetector configured to detect an initial chlorophyll a fluorescence (“ChlF”) light and an excited ChlF light from a plant species. The photodetector is further configured to convert the detected initial ChlF light into an initial detection electrical signal and the detected excited ChlF light into an excited detection electrical signal. The excited ChlF light is emitted from the plant species in response to receiving the excitation light. The controller module is configured to provide the excitation control signal to the excitation module, to capture the initial and excited detection electrical signals from the detection module and to determine chlorophyll fluorescence data based, at least in part, on the initial and excited detection electrical signals. The excitation LED module and the detection module are configured to be positioned remotely from the plant species. The chlorophyll fluorescence data represents a growth characteristic of the plant species. |
| FILED | Monday, February 10, 2020 |
| APPL NO | 16/786278 |
| ART UNIT | 2878 — Optics |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/64 (20130101) G01N 33/0098 (20130101) Original (OR) Class G01N 2201/062 (20130101) G01N 2201/0696 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11448965 | Zheng et al. |
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| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Yuebing Zheng (Austin, Texas); Linhan Lin (Austin, Texas); Jingang Li (Austin, Texas) |
| ABSTRACT | Disclosed herein are methods for patterning two-dimensional atomic layer materials, the methods comprising: illuminating a first location of an optothermal substrate with electromagnetic radiation, wherein the optothermal substrate converts at least a portion of the electromagnetic radiation into thermal energy, and wherein the optothermal substrate is in thermal contact with a two-dimensional atomic layer material; thereby: generating an ablation region at a location of the two-dimensional atomic layer material proximate to the first location of the optothermal substrate, wherein at least a portion of the ablation region has a temperature sufficient to ablate at least a portion of the two-dimensional atomic layer material within the ablation region, thereby patterning the two-dimensional atomic layer material. Also disclosed herein are systems for performing the methods described herein, patterned two-dimensional atomic layer materials made by the methods described herein and methods of use thereof. |
| FILED | Monday, July 22, 2019 |
| APPL NO | 17/262015 |
| ART UNIT | 2882 — Optics |
| CURRENT CPC | Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/202 (20130101) Original (OR) Class G03F 7/213 (20130101) G03F 7/702 (20130101) G03F 7/704 (20130101) G03F 7/2053 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11449380 | Didehban et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Moslem Didehban (Tempe, Arizona); Aviral Shrivastava (Phoenix, Arizona); Sai Ram Dheeraj Lokam (Chandler, Arizona) |
| ASSIGNEE(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| INVENTOR(S) | Moslem Didehban (Tempe, Arizona); Aviral Shrivastava (Phoenix, Arizona); Sai Ram Dheeraj Lokam (Chandler, Arizona) |
| ABSTRACT | A method for detecting and recovery from a soft error in a computing device is provided. In examples discussed herein, the method can be performed to detect soft errors that may occur during execution of a predefined critical instruction(s) and/or has been propagated in the computing device prior to the execution of the predefined critical instruction(s). Specifically, a software compiler may be used to embed an error detector block(s) after the predefined critical instruction(s). In this regard, the error detector block(s) can be executed after the predefined critical instruction(s) to detect the soft error. Accordingly, it may be possible to invoke a diagnosis routine to determine severity of the detected soft error and take appropriate action against the detected soft error. As such, it may be possible to protect the execution of the predefined critical instruction(s) concurrent to eliminating vulnerable voting intervals and reducing soft error detection overhead. |
| FILED | Thursday, May 23, 2019 |
| APPL NO | 16/420364 |
| ART UNIT | 2114 — Computer Error Control, Reliability, & Control Systems |
| CURRENT CPC | Electric Digital Data Processing G06F 11/079 (20130101) Original (OR) Class G06F 11/0706 (20130101) G06F 11/0793 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11449985 | Stanitsas et al. |
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| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota); Australian National University (Canberra, Australia) |
| ASSIGNEE(S) | Regents of the University of Minnesota (Minneapolis, Minnesota); Australian National University (Canberra ACT, Australia) |
| INVENTOR(S) | Panagiotis Stanitsas (Palo Alto, California); Anoop Cherian (Belmont, Massachusetts); Vassilios Morellas (Plymouth, Minnesota); Nikolaos Papanikolopoulos (Minneapolis, Minnesota); Alexander Truskinovsky (Williamsville, New York) |
| ABSTRACT | A system includes an imager, a processor, and an output module. The imager is configured to provide a plurality of tissue images. The processor is coupled to the imager and is configured to receive the plurality of images. The processor is coupled to a memory. The memory has instructions for determining classification of a region of tissue associated with the plurality of tissue images. Determining classification includes fusing discriminator outputs from a region covariance descriptor and from a normalized color histogram discriminator. The output module is coupled to the processor. The output module is configured to provide a three dimensional representation of the tissue. |
| FILED | Friday, December 01, 2017 |
| APPL NO | 15/829562 |
| ART UNIT | 2661 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation |
| CURRENT CPC | Electric Digital Data Processing G06F 3/04842 (20130101) G06F 3/04847 (20130101) Image Data Processing or Generation, in General G06T 5/40 (20130101) G06T 7/0012 (20130101) Original (OR) Class G06T 17/10 (20130101) G06T 2207/10024 (20130101) G06T 2207/10056 (20130101) G06T 2207/20021 (20130101) G06T 2207/20076 (20130101) G06T 2207/20081 (20130101) G06T 2207/20104 (20130101) G06T 2207/30024 (20130101) G06T 2207/30028 (20130101) G06T 2207/30061 (20130101) G06T 2207/30081 (20130101) G06T 2207/30096 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11450034 | Lebeck et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| INVENTOR(S) | Kiron Lebeck (Seattle, Washington); Tadayoshi Kohno (Seattle, Washington); Franziska Roesner (Seattle, Washington) |
| ABSTRACT | In some embodiments, an augmented reality system is provided. The augmented reality system is configured to detect real-world objects, create software objects that represent the real-world objects, receive requests from applications to present virtual objects at locations associated with the real-world objects, and to present the virtual objects. In some embodiments, an operating system of the augmented reality system is configured to resolve conflicts between requests from multiple applications. In some embodiments, the operating system of the augmented reality system is configured to provide information to applications to allow the applications to avoid or resolve conflicts amongst themselves. |
| FILED | Wednesday, December 11, 2019 |
| APPL NO | 17/413516 |
| ART UNIT | 2616 — Computer Graphic Processing, 3D Animation, Display Color Attribute, Object Processing, Hardware and Memory |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 11/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11450102 | Huo et al. |
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| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Ke Huo (West Lafayette, Indiana); Karthik Ramani (West Lafayette, Indiana) |
| ABSTRACT | A method and system for localizing a plurality of stationary devices, such as Internet of Things (IoT devices), arranged in an environment is disclosed. A mobile device is configured to survey an environment to generate a three-dimensional map of the environment using simultaneous localization and mapping (SLAM) techniques. The mobile device and the stationary devices are equipped with wireless transceivers, such as Ultra-wideband radios, for measuring distances between the devices using wireless ranging techniques. Based on the measured distances, the mobile device is configured to determine locations of the stationary devices in a reference frame of the three-dimensional map. In some embodiments, the determined locations can be used to enable a variety of spatially aware augmented reality features and interactions between the mobile device and the stationary device. |
| FILED | Wednesday, February 27, 2019 |
| APPL NO | 16/977616 |
| ART UNIT | 2611 — Computer Graphic Processing, 3D Animation, Display Color Attribute, Object Processing, Hardware and Memory |
| CURRENT CPC | Electric Digital Data Processing G06F 3/0484 (20130101) Image Data Processing or Generation, in General G06T 11/00 (20130101) G06T 15/00 (20130101) G06T 2200/24 (20130101) Image or Video Recognition or Understanding G06V 20/20 (20220101) Original (OR) Class Wireless Communication Networks H04W 88/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11450121 | Di Carlo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Dino Di Carlo (Los Angeles, California); Aydogan Ozcan (Los Angeles, California); Omai B. Garner (Culver City, California); Hector E. Munoz (Los Angeles, California); Carson Riche (Los Angeles, California) |
| ABSTRACT | An optical readout method for detecting a precipitate (e.g., a precipitate generated from the LAMP reaction) contained within a droplet includes generating a plurality of droplets, at least some which have a precipitate contained therein. The droplets are imaged using a brightfield imaging device. The image is subject to image processing using image processing software executed on a computing device. Image processing isolates individual droplets in the image and performs feature detection within the isolated droplets. Keypoints and information related thereto are extracted from the detected features within the isolated droplets. The keypoints are subject to a clustering operation to generate a plurality of visual “words.” The word frequency obtained for each droplet is input into a trained machine learning droplet classifier, wherein the trained machine learning droplet classifier classifies each droplet as positive for the precipitate or negative for the precipitate. |
| FILED | Tuesday, June 26, 2018 |
| APPL NO | 16/019421 |
| ART UNIT | 2174 — Graphical User Interface and Document Processing |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6844 (20130101) C12Q 1/6844 (20130101) C12Q 2531/119 (20130101) C12Q 2563/159 (20130101) C12Q 2565/601 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/30072 (20130101) Image or Video Recognition or Understanding G06V 10/464 (20220101) G06V 20/695 (20220101) Original (OR) Class G06V 20/698 (20220101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 40/10 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11450970 | Kamali et al. |
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| FUNDED BY |
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| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| INVENTOR(S) | Seyedeh Mahsa Kamali (Arcadia, California); Ehsan Arbabi (Arcadia, California); Andrei Faraon (La Canada Flintridge, California) |
| ABSTRACT | Cascaded metasurfaces can control the phase, amplitude and polarization of an electromagnetic beam, shaping it in three dimensional configuration not achievable with other methods. Each cascaded metasurface has dielectric or metallic scatterers arranged in a period array. The shape of the scatterers determines the three dimensional configuration of the output beam and is determined with iterative calculations through computational simulations. |
| FILED | Tuesday, December 04, 2018 |
| APPL NO | 16/209788 |
| ART UNIT | 2872 — Optics |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 1/002 (20130101) G02B 5/3083 (20130101) G02B 27/0012 (20130101) G02B 27/44 (20130101) G02B 27/0944 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/00 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/70408 (20130101) Antennas, i.e Radio Aerials H01Q 1/422 (20130101) H01Q 1/425 (20130101) H01Q 15/242 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11451261 | Stan et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| INVENTOR(S) | Mircea R. Stan (Charlottesville, Virginia); Luisa P. Gonzalez Guerrero (Knoxville, Tennessee) |
| ABSTRACT | Asynchronous stream generation and processing techniques are described that support implementation of an asynchronous stream mote in which one or more analog sensor signals are used to generate one or more asynchronous streams. On-device operations processing of the one or more asynchronous streams may be performed before transmission of the result(s) to other system components (e.g., peer motes or higher-level system components). |
| FILED | Friday, July 24, 2020 |
| APPL NO | 16/947249 |
| ART UNIT | 2633 — Digital Communications |
| CURRENT CPC | Coding; Decoding; Code Conversion in General H03M 3/464 (20130101) Transmission H04B 1/71635 (20130101) Original (OR) Class H04B 14/06 (20130101) Wireless Communication Networks H04W 84/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 11447275 | Mustafi et al. |
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| FUNDED BY |
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| APPLICANT(S) | United States of America as represented by the Administrator of NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | United States of America as represented by the Administrator of NASA (Washington, District of Columbia) |
| INVENTOR(S) | Shouvanik Mustafi (Greenbelt, Maryland); Matthew Francom (Greenbelt, Maryland); Xiaoyi Li (Greenbelt, Maryland); Daniel McGuinness (Greenbelt, Maryland); Ryan Simmons (Greenbelt, Maryland); Lloyd Purves (Greenbelt, Maryland) |
| ABSTRACT | A passive insulating tank support structure includes a first interface ring mounted to a first tank, a first support ring surrounding and spaced apart from the first interface ring, a second interface ring mounted to a second tank, a plurality of first struts coupling the first and second interface rings, a plurality of second struts coupling the first support ring and second interface ring, a plurality of third struts coupling the first support ring and a first heat source, a third interface ring mounted to the second tank, and a plurality of fourth struts coupling the third interface ring and a second heat source. |
| FILED | Tuesday, April 07, 2020 |
| APPL NO | 16/841800 |
| ART UNIT | 3736 — Sheet Container Making, Package Making, Receptacles, Shoes, Apparel, and Tool Driving or Impacting |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/54 (20130101) B64G 1/58 (20130101) B64G 1/402 (20130101) Original (OR) Class Vessels for Containing or Storing Compressed, Liquefied or Solidified Gases; Fixed-capacity Gas-holders; Filling Vessels With, or Discharging From Vessels, Compressed, Liquefied, or Solidified Gases F17C 13/001 (20130101) F17C 13/008 (20130101) F17C 2201/0128 (20130101) F17C 2203/0308 (20130101) F17C 2203/0366 (20130101) F17C 2203/0387 (20130101) F17C 2203/0663 (20130101) F17C 2221/011 (20130101) F17C 2221/012 (20130101) F17C 2223/0161 (20130101) F17C 2270/0194 (20130101) F17C 2270/0197 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447734 | Reiserer et al. |
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| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| INVENTOR(S) | Ronald S. Reiserer (Nashville, Tennessee); Gregory B. Gerken (Nashville, Tennessee); David K. Schaffer (Nashville, Tennessee); John P. Wikswo (Brentwood, Tennessee) |
| ABSTRACT | A continuous automated perfusion culture analysis system (CAPCAS) comprises one or more fluidic systems configured to operate large numbers of biodevices in parallel. Each fluidic system comprises an input reservoir plate for receiving media; a biodevice plate comprising an array of biodevices fluidically coupled to the input reservoir plate, configured such that each biodevice has independent media delivery, fluid removal, stirring, and gas control, and each biodevice is capable of continuously receiving the media from the input reservoir plate; and an output plate fluidically coupled to the biodevice plate for real-time analysis and sampling. The operations of the CAPCAS are automated and computer-controlled wirelessly. The CAPCAS can also be used for abiotic and biotic chemical synthesis processes. |
| FILED | Wednesday, January 19, 2022 |
| APPL NO | 17/578966 |
| ART UNIT | 1799 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/08 (20130101) C12M 23/10 (20130101) C12M 23/12 (20130101) C12M 23/16 (20130101) C12M 23/50 (20130101) C12M 23/58 (20130101) C12M 27/02 (20130101) C12M 27/12 (20130101) C12M 29/10 (20130101) Original (OR) Class C12M 35/02 (20130101) C12M 35/04 (20130101) C12M 41/48 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11448870 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America as represented by the Administrator of NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | United States of America as represented by the Administrator of NASA (Washington, District of Columbia) |
| INVENTOR(S) | Mary Li (Greenbelt, Maryland); Kyowon Kim (Greenbelt, Maryland); Alexander Kutyrev (College Park, Maryland); Matthew Greenhouse (Greenbelt, Maryland) |
| ABSTRACT | A microshutter array can have a frame, a plurality of linear microshutter elements, and a plurality of electrodes. The frame defines a plurality of openings and each opening is defined by a first sidewall, a second sidewall, a third sidewall opposing and parallel to the first sidewall, and a fourth sidewall. Each opening includes a light-transmissive portion configured to span an area. The plurality of linear microshutter elements are configured to extend across at least a part of the area. Each linear microshutter element can have a blade extending in a length direction across and blocking the light-transmissive portion. Each linear microshutter element can have a neck extending from the blade, and at least one torsion bar connected to the neck and connected to sidewalls of the frame. |
| FILED | Wednesday, April 29, 2020 |
| APPL NO | 16/862037 |
| ART UNIT | 2872 — Optics |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 26/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11451126 | Barchowsky et al. |
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| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| INVENTOR(S) | Ansel Barchowsky (Pasadena, California); Ryan W. Conversano (Pasadena, California); Christopher B. Stell (Valencia, California); Vatché Vorperian (Pasadena, California) |
| ABSTRACT | A flying capacitor multilevel (FCML) converter including a gate driver circuit comprising a DC-DC flyback converter having a plurality of isolated outputs. In various examples, the FCML circuit further includes a first control circuit connected to the FCML circuit determining the load current associated with a desired power output from the load; and determining a desired output voltage associated with the load current; a second control circuit that drives an inductor current (IL) through the inductor so that the output applies an output voltage comprising the desired output voltage; and a third control circuit obtaining a comparison of an average of the inductor current (IL) through the inductor with a predetermined reference current (ILREF) and setting the duty cycle so that the average does not exceed the predetermined reference current. Also described is the converter driving a load comprising a plasma and a propulsion system comprising the converter. |
| FILED | Thursday, August 27, 2020 |
| APPL NO | 17/005044 |
| ART UNIT | 2838 — Electrical Circuits and Systems |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/405 (20130101) B64G 1/428 (20130101) Producing a Reactive Propulsive Thrust, Not Otherwise Provided for F03H 1/0018 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 37/32009 (20130101) Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/08 (20130101) H02M 1/0095 (20210501) Original (OR) Class H02M 3/003 (20210501) H02M 3/335 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 11446887 | Jethmalani et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Novol, Inc. (San Leandro, California) |
| ASSIGNEE(S) | NOVOL, INC. (San Leandro, California) |
| INVENTOR(S) | Jagdish Jethmalani (San Leandro, California); Sanjiban Chakraborty (San Leandro, California); Monica Bhatia (San Leandro, California) |
| ABSTRACT | Provided herein are methods of molding thermoplastic polymers into optical elements. The optical elements in the form of cylindrical discs, semi-finished lens blanks or finished lenses are compression molded at high temperature typically above thermoplastic polymers softening temperature and under high pressure. The semi-finished lens blanks and finished lenses are molded using front and back glass molds inside a mold assembly which reshapes the cylindrical discs that are either previously molded or cut out from thick slab. Also provided are methods for producing single vision and progressive addition lens prescriptions. |
| FILED | Monday, October 26, 2020 |
| APPL NO | 17/080380 |
| ART UNIT | 1742 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 51/30 (20130101) Producing Particular Articles From Plastics or From Substances in a Plastic State B29D 11/0049 (20130101) Original (OR) Class B29D 11/00413 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2033/12 (20130101) B29K 2067/00 (20130101) B29K 2069/00 (20130101) B29K 2075/00 (20130101) B29K 2077/00 (20130101) B29K 2909/08 (20130101) Optical Elements, Systems, or Apparatus G02B 1/041 (20130101) Spectacles; Sunglasses or Goggles Insofar as They Have the Same Features as Spectacles; Contact Lenses G02C 7/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447482 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | KUDA Therapeutics, Inc. (Salt Lake City, Utah) |
| ASSIGNEE(S) | KUDA THERAPEUTICS, INC. (Salt Lake City, Utah) |
| INVENTOR(S) | Xiaohui Liu (Salt Lake City, Utah); Mei Yee Koh (Salt Lake City, Utah) |
| ABSTRACT | Novel substituted imidazopyridine and oxazolopyridine compounds that are useful as inhibitors of HIF-2α and inducers of ferroptosis through perturbations in iron metabolism, synthetic methods for making said compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds and compositions to treat disorders associated with dysfunction of HIF-2α or iron metabolism. |
| FILED | Friday, February 14, 2020 |
| APPL NO | 16/791148 |
| ART UNIT | 1625 — Organic Chemistry |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 417/12 (20130101) Original (OR) Class C07D 471/04 (20130101) C07D 487/04 (20130101) C07D 498/04 (20130101) C07D 513/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11448165 | Carlson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Valley Tech Systems, Inc. (Reno, Nevada) |
| ASSIGNEE(S) | Valley Tech Systems, Inc. (Reno, Nevada) |
| INVENTOR(S) | Russell Carlson (Reno, Nevada); Dustin Barr (Reno, Nevada); Allen Yan (Reno, Nevada) |
| ABSTRACT | An attitude control system for a guided missile includes a gas generator, an accumulator coupled to the gas generator, and a valve positioned between the gas generator and the accumulator. The gas generator contains propellant that burns to provide hot gas to pressurize the accumulator. The valve is opened to recharge the accumulator with hot gas and closed when it is full. A vent valve can be included to extinguish the propellant in the gas generator. The accumulator can be coupled to thrusters that use the stored hot gas to adjust the attitude of the guided missile. |
| FILED | Monday, March 23, 2020 |
| APPL NO | 16/827588 |
| ART UNIT | 3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/26 (20130101) B64G 1/244 (20190501) Jet-propulsion Plants F02K 9/80 (20130101) F02K 9/94 (20130101) Original (OR) Class F02K 9/95 (20130101) F02K 9/805 (20130101) Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 15/01 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11448881 | Browne |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Vision Products, LLC (Los Gatos, California) |
| ASSIGNEE(S) | Vision Products, LLC (Los Gatos, California) |
| INVENTOR(S) | Michael P. Browne (San Mateo, California) |
| ABSTRACT | A wide field of view night vision system is described. The system comprises a head attachment apparatus configured to attach to a user's head and a night vision subsystem. The night vision subsystem comprises one or more night vision image sensors attached to the head attachment apparatus. Each sensor receives input light and produces a digital image of the input light. A processor processes the digital image(s) to produce a wide-field image. The wide-field image spans at least 60 degrees of a user's horizontal field of view. A display and eyepiece attached to the head attachment apparatus receives and displays the wide-field image. The eyepiece is positionable between the display and the user's eye to image the wide-field image into the user's eye. |
| FILED | Monday, August 05, 2019 |
| APPL NO | 16/532407 |
| ART UNIT | 2485 — Recording and Compression |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 27/017 (20130101) Original (OR) Class G02B 2027/011 (20130101) G02B 2027/014 (20130101) G02B 2027/0123 (20130101) G02B 2027/0138 (20130101) Pictorial Communication, e.g Television H04N 5/33 (20130101) H04N 5/2258 (20130101) H04N 5/23238 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 11446887 | Jethmalani et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Novol, Inc. (San Leandro, California) |
| ASSIGNEE(S) | NOVOL, INC. (San Leandro, California) |
| INVENTOR(S) | Jagdish Jethmalani (San Leandro, California); Sanjiban Chakraborty (San Leandro, California); Monica Bhatia (San Leandro, California) |
| ABSTRACT | Provided herein are methods of molding thermoplastic polymers into optical elements. The optical elements in the form of cylindrical discs, semi-finished lens blanks or finished lenses are compression molded at high temperature typically above thermoplastic polymers softening temperature and under high pressure. The semi-finished lens blanks and finished lenses are molded using front and back glass molds inside a mold assembly which reshapes the cylindrical discs that are either previously molded or cut out from thick slab. Also provided are methods for producing single vision and progressive addition lens prescriptions. |
| FILED | Monday, October 26, 2020 |
| APPL NO | 17/080380 |
| ART UNIT | 1742 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 51/30 (20130101) Producing Particular Articles From Plastics or From Substances in a Plastic State B29D 11/0049 (20130101) Original (OR) Class B29D 11/00413 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2033/12 (20130101) B29K 2067/00 (20130101) B29K 2069/00 (20130101) B29K 2075/00 (20130101) B29K 2077/00 (20130101) B29K 2909/08 (20130101) Optical Elements, Systems, or Apparatus G02B 1/041 (20130101) Spectacles; Sunglasses or Goggles Insofar as They Have the Same Features as Spectacles; Contact Lenses G02C 7/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11447834 | Abebe et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Tuskegee University (Tuskegee, Alabama) |
| ASSIGNEE(S) | TUSKEGEE UNIVERSITY (Tuskegee, Alabama) |
| INVENTOR(S) | Woubit Abebe (Tuskegee, Alabama); Khaled Aldhami (Tuskegee, Alabama); Sayma Afroj (Tuskegee, Alabama); Temesgen Samuel (Tuskegee, Alabama); Gopal Reddy (Tuskegee, Alabama) |
| ABSTRACT | Disclosed are novel genetic arrays for use in the molecular detection of multiple Salmonella serovars, common food-borne and water-borne pathogens. The arrays may be used to simultaneously detect multiple food safety Salmonella serovars. The multiplex-detection methods have improved sensitivity and specificity for the detection of multiple high-impact food-borne pathogens simultaneously. Real-time PCR assaying techniques using such serovars include microarrays. |
| FILED | Tuesday, June 04, 2019 |
| APPL NO | 16/431039 |
| ART UNIT | 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50851 (20130101) B01L 2300/0829 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) Original (OR) Class C12Q 2561/101 (20130101) C12Q 2600/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 11446779 | Midyette et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Mark Midyette (Elizabeth City, North Carolina); Craig Deen (Elizabeth City, North Carolina); Harlon Parchment (Elizabeth City, North Carolina) |
| ABSTRACT | In one example, an on-wing method for in-situ cutting on a wing-to-fuselage attachment includes attaching a first mount plate having a first linear bearing to provide movement in a first linear direction relative to the first mount plate, attaching a second mount plate having a second linear bearing to provide movement in a second linear direction relative to the second mount plate, attaching a tool mounting member to the second linear bearing to move with the second linear bearing, attaching a cutter to the tool mounting member to be adjustable relative to the second linear bearing, adjusting a depth position of a cut to be made on the wing-to-fuselage attachment, adjusting a width position of the cut, and moving the tool along a length direction of the cut to make the cut on the wing-to-fuselage attachment along the length direction at the adjusted depth position and the adjusted width position. |
| FILED | Tuesday, May 18, 2021 |
| APPL NO | 17/323100 |
| ART UNIT | 3722 — Manufacturing Devices & Processes, Machine Tools & Hand Tools Group Art Units |
| CURRENT CPC | Milling B23C 1/20 (20130101) B23C 3/10 (20130101) B23C 3/36 (20130101) B23C 2215/04 (20130101) Details, Components, or Accessories for Machine Tools, e.g Arrangements for Copying or Controlling; Machine Tools in General Characterised by the Construction of Particular Details or Components; Combinations or Associations of Metal-working Machines, Not Directed to a Particular Result B23Q 9/0007 (20130101) Original (OR) Class B23Q 9/0028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11448766 | Sutherland et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | William T. Sutherland (Washington, District of Columbia); John Bray (Washington, District of Columbia) |
| ABSTRACT | Various embodiments of the present invention are directed towards a system and methods for generating three dimensional (3D) images with increased composite vertical field of view and composite resolution for a spinning three-dimensional sensor, based on actuating the sensor to generate a plurality of sensor axis orientations as a function of rotation of the actuator. The output data from the sensor, such as a spinning LIDAR, is transformable as a function of the actuator angle to generate three dimensional imagery. |
| FILED | Monday, July 12, 2021 |
| APPL NO | 17/373383 |
| ART UNIT | 3665 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems |
| CURRENT CPC | Vehicles, Vehicle Fittings, or Vehicle Parts, Not Otherwise Provided for B60R 2300/301 (20130101) Indexing Scheme Relating to Wind, Spring, Weight, Inertia or Like Motors, to Machines or Engines for Liquids Covered by Subclasses F03B, F03D and F03G F05B 2270/804 (20130101) F05B 2270/805 (20130101) F05B 2270/806 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/4813 (20130101) G01S 7/4817 (20130101) G01S 13/00 (20130101) G01S 15/00 (20130101) G01S 17/00 (20130101) G01S 17/88 (20130101) G01S 17/89 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 11446331 | Frank et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts); Children's Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | The Brigham and Women's Hospital, Inc. (Boston, Massachusetts); Children's Medical Center Corporation (Boston, Massachusetts); The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | Markus H. Frank (Cambridge, Massachusetts); Natasha Y. Frank (Cambridge, Massachusetts); Dennis P. Orgill (Belmont, Massachusetts); George F. Murphy (Boston, Massachusetts) |
| ABSTRACT | The present invention is directed to wound healing scaffolds cografted with a population of stem cells, wherein the population of stem cells are ABCB5+ stem cells. The scaffolds are, for instance, collagen glycosaminoglycan scaffolds. |
| FILED | Friday, May 09, 2014 |
| APPL NO | 14/890251 |
| ART UNIT | 1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) Original (OR) Class A61K 38/00 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/26 (20130101) A61L 27/26 (20130101) A61L 27/26 (20130101) A61L 27/26 (20130101) A61L 27/54 (20130101) A61L 27/56 (20130101) A61L 27/3834 (20130101) A61L 27/3886 (20130101) A61L 2430/16 (20130101) A61L 2430/34 (20130101) A61L 2430/40 (20130101) Compositions of Macromolecular Compounds C08L 5/08 (20130101) C08L 5/10 (20130101) C08L 89/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/063 (20130101) C12N 5/0668 (20130101) C12N 2533/30 (20130101) C12N 2533/54 (20130101) C12N 2533/70 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11446506 | Narayan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); TOPERA, INC. (Menlo Park, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California); The United States of America as Represented by the Department of Veterans Affairs (Washington, District of Columbia); Topera, Inc. (Menlo Park, California) |
| INVENTOR(S) | Sanjiv M. Narayan (Palo Alto, California); Carey Robert Briggs (La Jolla, California); Ruchir Sehra (Scottsdale, Arizona) |
| ABSTRACT | An example system and method associated with identifying and treating a source of a heart rhythm disorder are disclosed. In accordance therewith, a spatial element associated with a region of the heart is selected. Progressive rotational activations or progressive focal activations are determined in relation to the selected spatial element over a period of time. The selecting and determining are repeated over multiple periods of time. A source parameter of rotation activations or focal activations is determined, wherein the source parameter indicates consistency of successive rotational activations or focal activations in relation to a portion of the region of the heart. The determining of a source parameter is repeated for multiple regions of the heart. Thereafter, representation of the source parameter is displayed for each of the multiple regions of the heart to identify a shape representing the source of the heart rhythm disorder. |
| FILED | Thursday, September 05, 2019 |
| APPL NO | 16/562099 |
| ART UNIT | 3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0006 (20130101) A61B 5/287 (20210101) A61B 5/02405 (20130101) A61B 2018/00577 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 2230/06 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/365 (20130101) A61N 1/378 (20130101) A61N 1/3622 (20130101) A61N 1/3712 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 11451306 | Davanco |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE (Gaithersburg, Maryland) |
| INVENTOR(S) | Marcelo Ishihara Davanco (Rockville, Maryland) |
| ABSTRACT | A single quantum emitter single photon source produces a single photon stream and includes: a single-mode excitation waveguide that receives a pump light, propagates pump light as resonant excitation light, and produces evanescent excitation light; a separation gap between single-mode excitation waveguide and a multi-mode intermediate waveguide; a multi-mode intermediate waveguide that: includes a single quantum emitter, evanescently receives the evanescent excitation light from the single-mode excitation waveguide, propagates the evanescent excitation light as resonant excitation light, and subjects the single quantum emitter to the resonant excitation light such that the single quantum emitter produces emitted single photons; and a single-mode output waveguide that receives the emitted single photons from the multi-mode intermediate waveguide and propagates the emitted single photons as an emitted single photon stream. |
| FILED | Friday, May 15, 2020 |
| APPL NO | 16/875201 |
| ART UNIT | 2636 — Optical Communications |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/29337 (20130101) Transmission H04B 10/70 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 11451527 | Torres et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Palo Alto Research Center Incorporated (Palo Alto, California) |
| ASSIGNEE(S) | Palo Alto Research Center Incorporated (Palo Alto, California) |
| INVENTOR(S) | Francisco E. Torres (San Jose, California); Vanishree Hanumantha Rao (San Mateo, California); Shantanu Rane (Menlo Park, California); Yunhui Long (Urbana, Illinois) |
| ABSTRACT | Embodiments described herein provide a system for improving a classifier by computing a statistic for the utility of sharing data with a second party. The system may encrypt a set of class labels based on a public key/private key pair to obtain a set of encrypted class labels. The system may send a public key and the set of encrypted class labels to a second computing device. The system may receive an encrypted value computed by the second computing device based on the public key. The system may decrypt the encrypted value based on a private key to obtain a decrypted value. The system may then send a pair of encrypted values computed based on the decrypted value to the second computing device. The system may subsequently receive an encrypted utility statistic from the second computing device, and decrypt the encrypted utility statistic to obtain a decrypted utility statistic. |
| FILED | Wednesday, September 09, 2020 |
| APPL NO | 17/016073 |
| ART UNIT | 2494 — Cryptography and Security |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 63/061 (20130101) Original (OR) Class H04L 63/0435 (20130101) H04L 63/0442 (20130101) H04L 63/0853 (20130101) H04L 63/1416 (20130101) H04L 67/02 (20130101) H04L 67/141 (20130101) H04L 67/146 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of the Interior (DOI)
| US 11447541 | Westendorf et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AbCellera Biologies Inc. (Vancouver, Canada); The United States of America, as represented by the Secretary, Department of Health and Human Svcs. (Bethesda, Maryland) |
| ASSIGNEE(S) | AbCellera Biologies Inc. (Vancouver, Canada); The United States of America, as represented by the Secretary, Department of Health and Human Svcs. (Bethesda, Maryland) |
| INVENTOR(S) | Kathryn Westendorf (Vancouver, Canada); Stefanie Zentelis (Vancouver, Canada); Krithika Muthuraman (Toronto, Canada); Kevin Jepson (Vancouver, Canada); Ester Falconer (Vancouver, Canada); John Mascola (Bethesda, Maryland); Barney Graham (Bethesda, Maryland); Kizzmekia Corbett (Bethesda, Maryland); Julie Ledgerwood (Bethesda, Maryland); Lingshu Wang (Bethesda, Maryland); Olubukola Abiona (Bethesda, Maryland); Wei Shi (Bethesda, Maryland); Wing-pui Kong (Bethesda, Maryland); Yi Zhang (Bethesda, Maryland); Bryan Edward Jones (San Diego, California); Denisa Foster (San Diego, California); Julian Davies (La Jolla, California); Qing Chai (San Diego, California); Christopher Carl Frye (Bargersville, Indiana); Ganapathy Gopalrathnam (Fishers, Indiana); Jörg Hendle (San Diego, California); John Michael Sauder (Carlsbad, California); Jeffrey Streetman Boyles (Indianapolis, Indiana); Anna Pustilnik (San Diego, California) |
| ABSTRACT | Antibodies that bind SARS-CoV Spike protein, SARS-CoV-2 Spike protein, and methods of using same for treating or preventing conditions associated with SARS or COVID-19 and for detecting SARS-CoV or SARS-CoV-2. |
| FILED | Tuesday, June 22, 2021 |
| APPL NO | 17/354476 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/02 (20130101) A61K 47/26 (20130101) A61K 47/68 (20170801) A61K 47/183 (20130101) A61K 2039/54 (20130101) A61K 2039/545 (20130101) Peptides C07K 16/10 (20130101) Original (OR) Class C07K 2317/76 (20130101) C07K 2317/565 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Non-Profit Organization (NPO)
| US 11446335 | Agulnick et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ViaCyte, Inc. (San Diego, California) |
| ASSIGNEE(S) | ViaCyte, Inc. (San Diego, California) |
| INVENTOR(S) | Alan D. Agulnick (San Diego, California); Kevin Allen D'Amour (San Diego, California) |
| ABSTRACT | A human immature endocrine cell population and methods for making an immature endocrine cell population are provided. Specifically, immature beta cells and methods for production of immature beta cells are described. Immature beta cells co-express INS and NKX6.1 and are uni-potent and thereby develop into mature beta cells when implanted in vivo. The mature beta cells in vivo are capable of producing insulin in response to glucose stimulation. |
| FILED | Tuesday, June 25, 2019 |
| APPL NO | 16/452415 |
| ART UNIT | 1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/39 (20130101) Original (OR) Class A61K 35/545 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0676 (20130101) C12N 5/0676 (20130101) C12N 5/0676 (20130101) C12N 5/0678 (20130101) C12N 2500/25 (20130101) C12N 2501/15 (20130101) C12N 2501/16 (20130101) C12N 2501/115 (20130101) C12N 2501/117 (20130101) C12N 2501/119 (20130101) C12N 2501/155 (20130101) C12N 2501/195 (20130101) C12N 2501/385 (20130101) C12N 2501/415 (20130101) C12N 2501/727 (20130101) C12N 2501/998 (20130101) C12N 2501/999 (20130101) C12N 2506/02 (20130101) C12N 2506/02 (20130101) C12N 2506/45 (20130101) C12N 2506/45 (20130101) C12N 2533/90 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
How To Use This Page
THE FEDINVENT PATENT DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Tuesday, September 20, 2022.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week’s taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract as it appears on the patent.
FILED
The date of the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full-text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-patents-20220920.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page