FedInvent™ Patent Applications
Application Details for Thursday, January 05, 2023
This page was updated on Thursday, January 05, 2023 at 12:37 PM GMT
Department of Health and Human Services (HHS)
| US 20230000357 | Kim et al. |
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| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Young L. Kim (West Lafayette, Indiana); Md Munirul Haque (Fishers, Indiana); Michelle Amaris Visbal-Onufrak (Las Piedras, Puerto Rico); Sang Mok Park (West Lafayette, Indiana) |
| ABSTRACT | A system for generating hyperspectral imaging data for measuring biochemical compositions is disclosed which includes a spectral imaging device adapted to acquire one or more hyperspectral linescan images, an optical imaging device with a red-green-blue (RGB) sensor adapted to acquire an RGB dataset, a processor adapted to co-locate a plurality of pixels in the RGB dataset vs. a corresponding plurality of pixels of the one or more hyperspectral linescan datasets, establish a transformation matrix utilizing the plurality of co-located pixels, apply the transformation matrix to the RGB dataset to thereby generate the hyperspectral dataset, and analyze the generated hyperspectral image dataset to determine the biochemical compositions. |
| FILED | Tuesday, November 24, 2020 |
| APPL NO | 17/779492 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0075 (20130101) Original (OR) Class A61B 5/1455 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/31 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230000474 | Markowitz et al. |
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| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | Case Western Reserve University (Cleveland, Ohio) |
| INVENTOR(S) | Sanford Markowitz (Cleveland, Ohio); Amitabh Chak (Cleveland, Ohio); Joseph Willis (Cleveland, Ohio) |
| ABSTRACT | Provided herein are methods and a device for collecting biological samples from a subject. In particular, the present disclosure relates to a device designed to specifically capture samples within the target areas of a patient for specific cell collection for particular diagnosis. |
| FILED | Thursday, June 30, 2022 |
| APPL NO | 17/855515 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4233 (20130101) A61B 10/04 (20130101) Original (OR) Class A61B 2010/0216 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230000475 | Markowitz et al. |
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| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | Case Western Reserve University (Cleveland, Ohio) |
| INVENTOR(S) | Sanford Markowitz (Cleveland, Ohio); Amitabh Chak (Cleveland, Ohio); Joseph Willis (Cleveland, Ohio); Lishan Aklog (Purchase, New York); Richard Yazbeck (Norwell, Massachusetts); Michael Boutillette (San Francisco, California); Brian deGuzman (Paradise Valley, Arizona); David Wurtman (New York, New York) |
| ABSTRACT | Provided herein are methods and a device for collecting biological samples. In particular, the present disclosure relates to a device designed to specifically capture samples within the target areas of a patient for specific cell collection for particular diagnosis. |
| FILED | Thursday, June 30, 2022 |
| APPL NO | 17/855530 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 10/04 (20130101) Original (OR) Class A61B 2010/0216 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230000516 | del Nido et al. |
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| FUNDED BY |
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| APPLICANT(S) | Children's Medical Center Corporation (Boston, Massachusetts) |
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| INVENTOR(S) | Pedro Jose del Nido (Lexington, Massachusetts); Borami Shin Lee (Dorchester, Massachusetts); Christopher James Payne (Cambridge, Massachusetts); Mossab YM Saeed (Revere, Massachusetts) |
| ABSTRACT | A device for minimally invasive, inter-layer surgical procedures advantageously forms a wedge for advancing between adjacent tissue layers and provides a jaw that can be actuated to create a working space for a cutting tool and other instruments within a plane between the tissue layers. The device may also usefully employ an open or wireframe structure for the opposing jaws to preventing tissue or fluid accumulation between the jaws and maximize visibility around the surgical site. |
| FILED | Tuesday, August 30, 2022 |
| APPL NO | 17/898892 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/05 (20130101) A61B 1/00087 (20130101) A61B 1/313 (20130101) A61B 17/320016 (20130101) Original (OR) Class A61B 2017/320044 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230000612 | Papas |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
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| INVENTOR(S) | Klearchos K. Papas (Tucson, Arizona) |
| ABSTRACT | Systems featuring two or more encapsulation devices stacked together. The encapsulation devices house cells, such as but not limited to islet cells or stem cell derived beta cells or the like. e.g., for regulating blood glucose, or other cells or spheroids that can produce and release a therapeutic agent that is useful in the body, etc. The system may feature oxygen delivery, or in some cases no exogenous oxygen is delivered and vascularization of the device can help provide oxygen and other needed nutrient to the cells. The system of the present invention may be used in conjunction with other therapies such as an artificial pancreas. Stacking the devices with blood vessel formation around and in between them may allow for a decrease in the footprint that would be needed for implantation. |
| FILED | Friday, September 02, 2022 |
| APPL NO | 17/902689 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/022 (20130101) Original (OR) Class A61F 2220/0075 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/52 (20130101) A61L 27/54 (20130101) A61L 27/225 (20130101) A61L 27/227 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230000760 | Du et al. |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Yiqin Du (Pittsburgh, Pennsylvania); Ajay Kumar (Pittsburgh, Pennsylvania) |
| ABSTRACT | Compositions for treating an ocular disorder are provided. The composition includes an effective amount of a human trabecular meshwork stem cell (TMSC) secretome, wherein the effective amount is present in an amount to reduce impairment of retinal ganglion cells (RGC). Methods for treating ocular disorders using the disclosed compositions are also provided. The compositions reduce and prevent cell apoptosis, axon loss, vision loss, increased intraocular pressure, and dysregulated aqueous humor outflow of a subject when used in accordance with the methods disclosed herein. |
| FILED | Friday, September 02, 2022 |
| APPL NO | 17/902050 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) Original (OR) Class A61K 35/28 (20130101) A61K 35/30 (20130101) A61K 2121/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0621 (20130101) C12N 2533/90 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230000771 | Hong et al. |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
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| INVENTOR(S) | Seungpyo Hong (Madison, Wisconsin); Allan Brasier (Madison, Wisconsin); Weiping Tang (Middleton, Wisconsin) |
| ABSTRACT | A self-assembled therapeutic dendron-micelle includes a first amphiphilic dendron-coil, a second amphiphilic dendron-coil, and optionally a third amphiphilic dendron-coil, and an encapsulated BRD4 ligand or BRD4 proteolysis targeting chimera. The first and optional third amphiphilic dendron-coils have a therapeutic peptide conjugated thereto. Also included are pharmaceutical compositions containing the dendron-micelles, methods of making the dendron-micelles, and therapeutic methods including administering the dendron-micelles to a subject in need thereof. |
| FILED | Wednesday, June 15, 2022 |
| APPL NO | 17/840964 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1075 (20130101) Original (OR) Class A61K 47/10 (20130101) A61K 47/34 (20130101) A61K 47/6935 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230000798 | Tesar et al. |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
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| INVENTOR(S) | Paul J. Tesar (Wickliffe, Ohio); Drew Adams (Cleveland, Ohio); Zita Hubler (Cleveland, Ohio); Matthew Elitt (St. Louis, Missouri); Dharmaraja Allimuthu (Cleveland, Ohio); Steven B. Landau (Wellesley, Massachusetts) |
| ABSTRACT | A method of promoting the generation of oligodendrocytes from oligodendrocyte precursor cells by enhancing their survival and/or maturation includes administering to the cell an effective amount of an agent that enhances and/or induces accumulation of Δ8,9-unsaturated sterol intermediates of the cholesterol biosynthesis pathway in the oligodendrocyte precursor cells. |
| FILED | Friday, May 27, 2022 |
| APPL NO | 17/826252 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/136 (20130101) A61K 31/137 (20130101) Original (OR) Class A61K 31/138 (20130101) A61K 31/198 (20130101) A61K 31/496 (20130101) A61K 31/4174 (20130101) A61K 31/4196 (20130101) A61K 31/4535 (20130101) A61K 31/4545 (20130101) A61K 31/5375 (20130101) A61K 31/7105 (20130101) A61K 38/16 (20130101) A61K 38/215 (20130101) A61K 39/3955 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/14 (20180101) A61P 25/28 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/50 (20130101) C12N 15/1137 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230000799 | LIECHTI |
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| APPLICANT(S) | Universitätsspital Basel (Basel, Switzerland) |
| ASSIGNEE(S) | Universitätsspital Basel (Basel, Switzerland) |
| INVENTOR(S) | Matthias Emanuel LIECHTI (Oberwil, Switzerland) |
| ABSTRACT | A method of inducing psychedelic states in an individual, by administering mescaline, a salt thereof, analogs thereof, or derivatives thereof to the individual, and inducing a psychedelic state in the individual. A method of therapy, by administering an intermediate “good effect dose” of mescaline, salt of mescaline, analogs thereof, or derivatives thereof to an individual, and inducing positive acute drug effects that are known to be associated with more positive long-term responses in psychiatric patients. A method of therapy, by administering an “ego-dissolution” dose of mescaline, a salt of mescaline, analogs thereof, or derivatives thereof to an individual, and providing the experience of ego-dissolution. |
| FILED | Monday, August 08, 2022 |
| APPL NO | 17/883502 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/137 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230000818 | BABAN et al. |
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| APPLICANT(S) | AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC. (Augusta, Georgia) |
| ASSIGNEE(S) | AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC. (Augusta, Georgia) |
| INVENTOR(S) | Babak BABAN (Augusta, Georgia); Krishnan DHANDAPANI (Evans, Georgia); Jack C. YU (Martinez, Georgia) |
| ABSTRACT | Compositions and methods for treating or reducing symptoms of acute respiratory distress syndrome (ARDS) generally and COVID-19 infection in particular are provided herein. An exemplary method includes administering to the subject an effective amount of cannabichromene to reduce acute respiratory distress syndrome caused by ARDS generally and COVID-19 infection in particular. |
| FILED | Friday, July 01, 2022 |
| APPL NO | 17/810484 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0073 (20130101) A61K 31/352 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230000830 | Day et al. |
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| APPLICANT(S) | National Jewish Health (Denver, Colorado) |
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| INVENTOR(S) | Brian J. Day (Englewood, Colorado); Carl W. White (Denver, Colorado) |
| ABSTRACT | Compounds may be administered to prevent or rescue organ injury following exposure to alkylating agents, such as sulfur mustards. The compounds may be substituted metalloporphyrins. |
| FILED | Tuesday, May 03, 2022 |
| APPL NO | 17/735378 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/409 (20130101) A61K 31/427 (20130101) A61K 31/555 (20130101) A61K 31/4178 (20130101) Original (OR) Class A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230000831 | BOZIK et al. |
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| APPLICANT(S) | Knopp Biosciences LLC (Pittsburgh, Pennsylvania) |
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| INVENTOR(S) | Michael E. BOZIK (Wexford, Pennsylvania); Scott S. HARRIED (Sun Prairie, Wisconsin); Lynn RESNICK (Pittsburgh, Pennsylvania); George T. TOPALOV (Pittsburgh, Pennsylvania); Justin K. BELARDI (Pittsburgh, Pennsylvania); Charles A. FLENTGE (Mars, Pennsylvania); David A. MARESKA (Pittsburgh, Pennsylvania); James S. HALE (Pittsburgh, Pennsylvania) |
| ABSTRACT | Provided herein are optionally substituted benzoimidazol-1,2-yl amides, pharmaceutical compositions comprising a therapeutically effective amount of such compounds and a pharmaceutically acceptable excipient, and methods of treating Kv7 associated diseases, such as, epilepsy, amyotrophic lateral sclerosis, various types of pain, hyperexcitability, a dyskinesia, dystonia, mania and tinnitus with such compounds and pharmaceutical compositions. |
| FILED | Friday, January 07, 2022 |
| APPL NO | 17/570536 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4184 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230000844 | DESAI et al. |
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| APPLICANT(S) | Abraxis BioScience, LLC (Summit, New Jersey) |
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| INVENTOR(S) | Neil P. DESAI (Pacific Palisades, California); Anita N. SCHMID (Berkeley Heights, New Jersey); Shihe HOU (Millington, New Jersey); Andrew KWON (Hawthorne, California) |
| ABSTRACT | The present application provides methods and compositions for treating cancer by administering a composition comprising nanoparticles that comprise an mTOR inhibitor (such as a limus drug) and a carrier protein (such as an albumin) based upon the mutation status of TSC1 or TSC2 and one of VHL, RBI, PBRIM1, K.DM6A, RET, SETD2 ARID 1 A, BAP1, BRCA2, TP53, RBI, ATRX, FLT1, NTRK1, TLX3, KDM6A, CDH4, CDKN2C, DAXX, ERBB3, GNAS, IL7R, PDGFRB, PMS2, PTEN, SMARCA4, and YY1AP1. |
| FILED | Wednesday, November 11, 2020 |
| APPL NO | 17/775562 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/5169 (20130101) A61K 31/44 (20130101) Original (OR) Class A61K 47/42 (20130101) A61K 47/6929 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230000857 | Boger et al. |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland); THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ravit Boger (Baltimore, Maryland); Marc Ferrer (Potomac, Maryland); Juan Marugan (Gaithersburg, Maryland); Andres Dulcey Garcia (Gaithersburg, Maryland); Noel Terrence Southall (Potomac, Maryland); Xin Hu (Frederick, Maryland) |
| ABSTRACT | The present invention relates to the field of virology. More specifically, the present invention provides methods and compositions useful for prevention and treatment of human cytomegalovirus (CMV). In one embodiment, a pharmaceutical composition comprises (a) emetine or a derivative thereof; (b) a human cytomegalovirus (HCMV) drug; and (c) a pharmaceutically acceptable carrier. In certain embodiments, the pharmaceutical composition further comprises an adjuvant. In a specific embodiment, the HCMV drug is ganciclovir. In such embodiments, emetine is present at about 1/10 to about 1/100 the normal dosage for amebiasis. |
| FILED | Friday, February 11, 2022 |
| APPL NO | 17/669425 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/522 (20130101) A61K 31/4745 (20130101) Original (OR) Class A61K 38/05 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/20 (20180101) A61P 31/22 (20180101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230000869 | Yu et al. |
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| APPLICANT(S) | The Brigham and Women's Hospital, Inc. (Boston, Massachusetts); The United States of America, as Represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul B. Yu (Boston, Massachusetts); Wenwei Huang (Rockville, Maryland); Philip Edward Sanderson (Bethesda, Maryland); Jian-Kang Jiang (Columbia, Maryland); Khalida Shamim (Gaithersburg, Maryland); Wei Zheng (Potomac, Maryland); Xiuli Huang (Potomac, Maryland); Gregory Tawa (Doylestown, Pennsylvania); Arthur Lee (San Jose, California); Asaf Alimardanov (North Bethesda, Maryland); Junfeng Huang (Woodstock, Maryland) |
| ABSTRACT | The present invention provides small-molecule inhibitors of BMP signaling and compositions and methods for inhibiting BMP signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds and compositions may also be used to treat subjects with Sjögren's syndrome, or diffuse intrinsic pontine glioma (DIPG). |
| FILED | Monday, June 07, 2021 |
| APPL NO | 17/340589 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) Original (OR) Class A61K 31/551 (20130101) A61K 31/675 (20130101) A61K 31/5377 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/08 (20180101) Heterocyclic Compounds C07D 487/04 (20130101) C07D 519/00 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/6561 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230000881 | Zuo et al. |
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| FUNDED BY |
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| APPLICANT(S) | St. Jude Children's Research Hospital (Memphis, Tennessee) |
| ASSIGNEE(S) | St. Jude Children's Research Hospital (Memphis, Tennessee) |
| INVENTOR(S) | Jian Zuo (Omaha, Nebraska); Tal Teitz (Omaha, Nebraska); Fang Jie (Memphis, Tennessee); Goktug Asli (Memphis, Tennessee); Chen Taosheng (Germantown, Tennessee); Min Jaeki (Memphis, Tennessee); R. Kiplin Guy (Memphis, Tennessee) |
| ABSTRACT | In one aspect, pharmaceutical compositions comprising a CDK2 inhibitor and one or more of at least one agent known to treat a hearing impairment and at least one agent known to prevent a hearing impairment, and methods of treating and/or preventing hearing impairments or disorders using the compositions are disclosed. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| FILED | Tuesday, July 12, 2022 |
| APPL NO | 17/862656 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/52 (20130101) A61K 31/55 (20130101) Original (OR) Class A61K 31/404 (20130101) A61K 31/454 (20130101) A61K 31/506 (20130101) A61K 31/519 (20130101) A61K 31/4015 (20130101) A61K 31/4155 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/16 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230000885 | Thompson |
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| APPLICANT(S) | University of Maryland, Baltimore (Baltimore, Maryland) |
| ASSIGNEE(S) | University of Maryland, Baltimore (Baltimore, Maryland) |
| INVENTOR(S) | Scott Thompson (Baltimore, Maryland) |
| ABSTRACT | Provided herein are methods for preventing or treating a psychological disorder. A serotonin agonist or an agonist of serotonin receptors is administered separately, sequentially or simultaneously in combination with a serotonin receptor 2A antagonist. |
| FILED | Thursday, September 08, 2022 |
| APPL NO | 17/940950 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/36 (20130101) A61K 31/517 (20130101) A61K 31/675 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230000887 | Acharya et al. |
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| APPLICANT(S) | AyuVis Research, Inc. (Fort Worth, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Suchismita Acharya (Grapevine, Texas); Santosh K. Panda (Maryland Heights, Missouri) |
| ABSTRACT | The present invention includes novel compositions and methods for treating comprising a compound with the Formula I: wherein n=0, 1, 2, 3, 4, or 5; X=NH or O or S; Y=phenyl, or a phenyl group substituted with at least one methyl, a phenyl group substituted with at least one nitro, a phenyl group substituted with at least one nitrogen, a phenyl group substituted with at least one boron, aryl, substituted aryl, heteroaryl, four to six membered cycloalkyl, four to six membered heterocycloalkyl; R=H, C(O)R2, SO2R2; R1=H, C(O)R2, SO2R2; R2=Ethyl, methyl, isopropyl, n-propyl, t-butyl, n-butyl, NH2, NR3R4; R3, R4=Ethyl, methyl, isopropyl, n-propyl, t-butyl, n-butyl, three to six membered cycloalkyl, and Z=NH, or O, or none, and optionally wherein both X and Z are not both S, and wherein the amount of the compound is selected to either inhibit or activate the immune response. |
| FILED | Wednesday, May 25, 2022 |
| APPL NO | 17/824362 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0043 (20130101) A61K 9/0073 (20130101) A61K 9/5153 (20130101) A61K 31/702 (20130101) Original (OR) Class A61K 31/7034 (20130101) A61K 31/7036 (20130101) A61K 31/7048 (20130101) A61K 31/7056 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230000891 | Burke et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin D. Burke (Champaign, Illinois); Arun Maji (Champaign, Illinois); Jiabao Zhang (Urbana, Illinois) |
| ABSTRACT | Disclosed are C16 ester derivatives of C2′epi-amphotericin B (C2′epiAmB) characterized by improved clinical efficacy with reduced toxicity compared to AmB. Also disclosed are pharmaceutical compositions comprising the C16 ester derivatives of C2′epiAmB, therapeutic methods of using the C16 ester derivatives of C2′epiAmB, and methods of making the C16 ester derivatives of C2′epiAmB. |
| FILED | Friday, August 07, 2020 |
| APPL NO | 17/633282 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7048 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/10 (20180101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 17/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230000893 | Schinazi et al. |
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| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Raymond F. Schinazi (Atlanta, Georgia); Franck Amblard (Atlanta, Georgia); Bryan D. Cox (Suwanee, Georgia); Leda Bassit (Smyrna, Georgia); Longhu Zhou (Atlanta, Georgia); Christina Gavegnano (Atlanta, Georgia) |
| ABSTRACT | The present invention is directed to compounds, compositions and methods for treating or preventing Zika virus. The compounds include pyrimidine and purine nucleosides and prodrugs thereof, including certain N4-hydroxycytidine nucleoside derivatives, sulfasalazine, and various entry inhibitors. |
| FILED | Wednesday, March 22, 2017 |
| APPL NO | 16/088017 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/53 (20130101) A61K 31/655 (20130101) A61K 31/4706 (20130101) A61K 31/7064 (20130101) A61K 31/7068 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230000908 | DONG et al. |
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| FUNDED BY |
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| APPLICANT(S) | OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yizhou DONG (Dublin, Ohio); Xucheng HOU (Columbus, Ohio); Xinfu ZHANG (Dalian, China PRC) |
| ABSTRACT | The present disclosure relates to antigen presenting cells and uses thereof for treating sepsis. In some aspects, disclosed herein is an antigen presenting cell, comprising: a lipid-based nanoparticle, comprising: a recombinant polynucleotide, comprising: a first nucleic acid encoding an antimicrobial peptide; a second nucleic acid encoding cathepsin B; and a third nucleic acid encoding a linker; and a vitamin-lipid. |
| FILED | Thursday, September 10, 2020 |
| APPL NO | 17/642320 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5123 (20130101) A61K 35/15 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 7/08 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/6472 (20130101) Enzymes C12Y 304/22001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230000912 | Bernstein et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BROAD INSTITUTE, INC. (, None); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (, None); THE GENERAL HOSPITAL CORPORATION (, None) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bradley Bernstein (Boston, Massachusetts); Itay Tirosh (Cambridge, Massachusetts); Mario Suva (Boston, Massachusetts); Aviv Regev (Cambridge, Massachusetts); Orit Rozenblatt-Rosen (Cambridge, Massachusetts); Andrew Venteicher (Boston, Massachusetts) |
| ABSTRACT | This invention relates generally to compositions and methods for identifying genes and gene networks that respond to, modulate, control or otherwise influence tumors and tissues, including cells and cell types of the tumors and tissues, and malignant, microenvironmental, or immunologic states of the tumor cells and tissues. The invention also relates to methods of diagnosing, prognosing and/or staging of tumors, tissues and cells, and provides compositions and methods of modulating expression of genes and gene networks of tumors, tissues and cells, as well as methods of identifying, designing and selecting appropriate treatment regimens. |
| FILED | Wednesday, January 25, 2017 |
| APPL NO | 16/072674 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/30 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/112 (20130101) C12Q 2600/118 (20130101) C12Q 2600/136 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57407 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230000921 | BAJAJ |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VIRGINIA COMMONWEALTH UNIVERSITY (Richmond, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jasmohan BAJAJ (Richmond, Virginia) |
| ABSTRACT | A composition of fecal material is prepared and administered to a subject suffering from alcohol craving, alcohol consumption and/or alcohol use disorder. The donor fecal material is enriched in beneficial microbiota associated with reduced alcohol craving and/or consumption and supplies beneficial microbiota in which the recipient is deficient, and reduces harmful microbes. Methods of preparing and administering are disclosed, along with the identification of beneficial and harmful microbiota families. The treatment is also useful for delivery of microbiota that are short chain fatty acid producers to reduce alcohol craving and/or consumption in subjects deficient in short chain fatty acids. |
| FILED | Monday, November 02, 2020 |
| APPL NO | 17/780728 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/24 (20130101) Original (OR) Class A61K 35/741 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/32 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230000928 | Yoon et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| INVENTOR(S) | Hye-Sook Yoon (Rochester, Minnesota); Isobel A. Scarisbrick (Rochester, Minnesota) |
| ABSTRACT | Materials and methods for modulating protease activated receptor 2 (PAR2) activity in order to alter myelination or demyelination are provided herein. |
| FILED | Wednesday, September 14, 2022 |
| APPL NO | 17/944699 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/00 (20130101) A61K 31/7088 (20130101) A61K 35/545 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Peptides C07K 16/28 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0606 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230000961 | Kim et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Jaeyun Kim (Cambridge, Massachusetts); Weiwei Aileen Li (Norcross, Georgia); David J. Mooney (Sudbury, Massachusetts) |
| ABSTRACT | A composition comprising mesoporous silica rods comprising an immune cell recruitment compound and an immune cell activation compound, and optionally comprising an antigen such as a tumor lysate. The composition is used to elicit an immune response to a vaccine antigen. |
| FILED | Friday, March 11, 2022 |
| APPL NO | 17/693017 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/1611 (20130101) A61K 38/18 (20130101) A61K 38/193 (20130101) A61K 39/0011 (20130101) Original (OR) Class A61K 39/39 (20130101) A61K 39/00117 (20180801) A61K 39/00118 (20180801) A61K 39/001102 (20180801) A61K 39/001156 (20180801) A61K 39/001162 (20180801) A61K 39/001171 (20180801) A61K 39/001182 (20180801) A61K 39/001184 (20180801) A61K 39/001186 (20180801) A61K 39/001191 (20180801) A61K 39/001192 (20180801) A61K 2039/80 (20180801) A61K 2039/55522 (20130101) A61K 2039/55555 (20130101) A61K 2039/55561 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230000973 | Barouch et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Janssen Vaccines and Prevention B.V. (Leiden, Netherlands); Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dan H. Barouch (Newton, Massachusetts); Boris D. Juelg (Winchester, Massachusetts); Maria Grazia Pau (Leiden, Netherlands); Frank Tomaka (Titusville, New Jersey) |
| ABSTRACT | Methods for inducing an immune response against Human Immunodeficiency Virus (HIV) in HIV-infected subjects undergoing antiretroviral therapy (ART) are described. The methods involve initial administration of an adenovirus vector vaccine and subsequent administration of a poxvirus vector vaccine, followed by administration of anti-HIV broadly neutralizing antibodies (bNAb). |
| FILED | Thursday, June 23, 2022 |
| APPL NO | 17/808348 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 39/21 (20130101) Original (OR) Class A61K 39/42 (20130101) A61K 2039/5256 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) A61P 37/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230000979 | Bornholdt et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Albert Einstein College of Medicine (Bronx, New York); Adimab, LLC (Lebanon, New Hampshire); Mapp Biopharmaceutical, Inc. (San Diego, California); Board of Regents, The University of Texas System (Austin, Texas); The Government of the United States, as represented by the Secretary of the Army (Frederick, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zachary A. Bornholdt (Encinitas, California); Akaash Mishra (Austin, Texas); Laura M. Walker (Norwich, Vermont); Noel T. Pauli (Lebanon, New Hampshire); Daniel Maurer (Cambridge, Massachusetts); Kartik Chandran (Bronx, New York); Jens Maximilian Fels (Bronx, New York); Dafna Abelson (San Diego, California); Jason Scott McLellan (Austin, Texas); Jonathan R. Lai (Bronx, New York); Ariel Wirchnianski (Bronx, New York); Olivia Vergnolle (Bronx, New York); John M. Dye (Frederick, Maryland); Andrew S. Herbert (Frederick, Maryland) |
| ABSTRACT | Anti-CCHFV antibodies with neutralizing potency and protective efficacy against CCHFV are provided, as well as methods for their identification, isolation, generation, and methods for their preparation and use are provided. |
| FILED | Tuesday, May 31, 2022 |
| APPL NO | 17/829164 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/42 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230000986 | BURTON |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Michael D. BURTON (Richardson, Texas) |
| ABSTRACT | Disclosed is an important therapeutic strategy of targeting MNK to block eIF4E phosphorylation for the treatment of persistent inflammatory pain in later life. In one embodiment, a therapeutic drug that targets MNK and inhibits MNK is selected in order to block eIF4E phosphorylation and the therapeutic drug is administered to the subject with sufficient dosage to block eIF4E phosphorylation. The treatment is suitable for aged subjects experiencing inflammatory pain such as age-associated inflammation, age-associated low-grade inflammation, CFA-induced acute inflammation, spontaneous pain, mechanical hypersensitivity or thermal hypersensitivity. |
| FILED | Friday, July 01, 2022 |
| APPL NO | 17/810404 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Original (OR) Class A61K 2121/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230000994 | Crew et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARVINAS OPERATIONS, INC. (New Haven, Connecticut); YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew P. Crew (Chester, Connecticut); Keith R. Hornberger (Southbury, Connecticut); Jing Wang (Milford, Connecticut); Saul Jaime-Figueroa (Morris Plains, New Jersey); Hanqing Dong (Madison, Connecticut); Lawrence B. Snyder (Killingworth, Connecticut) |
| ABSTRACT | The present disclosure relates to bifunctional compounds, which find utility as modulators of Rapidly Accelerated Fibrosarcoma (RAF, such as c-RAF, A-RAF and/or B-RAF; the target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a Von Hippel-Lindau, cereblon, Inhibitors of Apotosis Proteins or mouse double-minute homolog 2 ligand which binds to the respective E3 ubiquitin ligase and on the other end a moiety which binds the target protein RAF, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein, or the constitutive activation of the target protein, are treated or prevented with compounds and compositions of the present disclosure. |
| FILED | Wednesday, July 28, 2021 |
| APPL NO | 17/387621 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/55 (20170801) Original (OR) Class Heterocyclic Compounds C07D 413/14 (20130101) C07D 417/14 (20130101) C07D 471/04 (20130101) C07D 519/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230000996 | Hong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland); Rapafusyn Research and Development, Inc. (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sam Hong (Baltimore, Maryland); Brett R. Ullman (Baltimore, Maryland); Joseph E. Semple (Baltimore, Maryland); Kana Yamamoto (Baltimore, Maryland); Puneet Kumar (Baltimore, Maryland); Magesh Sadagopan (Baltimore, Maryland); Jennifer C. Schmitt (Baltimore, Maryland); Jun Liu (Baltimore, Maryland) |
| ABSTRACT | The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocyles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases. |
| FILED | Wednesday, September 30, 2020 |
| APPL NO | 17/765814 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/55 (20170801) A61K 47/64 (20170801) Original (OR) Class A61K 47/545 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230001003 | Williams et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | City of Hope (Duarte, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John C. Williams (Duarte, California); David A. Horne (Duarte, California); Yuelong Ma (Duarte, California); Heng Wei Chang (Foster City, California); Joshua Michael Donaldson (Lumberton, New Jersey); Cindy Zer (Duarte, California); Krzysztof Bzymek (Pasadena, California); Kendra Nicole Avery (Pasadena, California); Jun Xie (Duarte, California) |
| ABSTRACT | Antibodies and meditopes that bind to the antibodies are provided, as well as complexes, compositions and combinations containing the meditopes and antibodies, and methods of producing, using, testing, and screening the same, including therapeutic and diagnostic methods and uses. |
| FILED | Monday, December 20, 2021 |
| APPL NO | 17/556863 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/66 (20170801) A61K 47/6811 (20170801) Original (OR) Class A61K 47/6813 (20170801) A61K 47/6851 (20170801) A61K 47/6877 (20170801) A61K 47/6897 (20170801) A61K 51/1087 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Peptides C07K 16/18 (20130101) C07K 16/32 (20130101) C07K 16/2863 (20130101) C07K 2299/00 (20130101) C07K 2317/34 (20130101) C07K 2317/40 (20130101) C07K 2317/55 (20130101) C07K 2317/92 (20130101) C07K 2317/567 (20130101) C07K 2317/622 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230001009 | Myerson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jacob Myerson (Clayton, Missouri); Jacob Brenner (Princeton Junction, New Jersey); Vladimir Muzykantov (Bryn Athyn, Pennsylvania); Landis R. Walsh (Winchester, Massachusetts); Priyal Patel (Philadelphia, Pennsylvania) |
| ABSTRACT | Provided herein are compositions comprising a nanoparticle and a D20 tag. The D20 tag comprises dibenzocyclooctyne (DBCO) covalently attached to a protein. Also provided are diagnostic and therapeutic methods utilizing the nanoparticle composition. |
| FILED | Thursday, December 03, 2020 |
| APPL NO | 17/781945 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/1272 (20130101) A61K 47/42 (20130101) A61K 47/62 (20170801) A61K 47/6913 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230001013 | APPEL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Palo Allto, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric A. APPEL (Palo Alto, California); Caitlin MAIKAWA (Boston, Massachusetts); Anton Allen Abbotsford SMITH (Kgs. Lyngby, Denmark) |
| ABSTRACT | Stable monomeric insulin formulations are enabled by supramolecular PEGylation of insulin or insulin analogues, and provide a method for treating diabetes, or managing or reducing blood glucose. |
| FILED | Monday, December 14, 2020 |
| APPL NO | 17/784907 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/22 (20130101) A61K 38/28 (20130101) A61K 47/02 (20130101) A61K 47/10 (20130101) A61K 47/26 (20130101) A61K 47/60 (20170801) A61K 47/6949 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230001014 | SHAYAKHMETOV et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ADCURE BIOTECHNOLOGIES, LLC. (SNELLVILLE, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | DMITRY M. SHAYAKHMETOV (SNELLVILLE, Georgia); NELSON C. DI PAOLO (AVONDALE ESTATES, Georgia) |
| ABSTRACT | The present disclosure describes the generation and the use of Ad variants (Ad) possessing any combination of mutations in genes that code for the hexon, penton, fiber, and non-structural proteins, where simultaneous modification of hexon and penton are made to avoid the trapping of Ad in the liver and to reduce toxicity after intravascular virus administration. Such liver de-targeted Ad can be useful tool for selective and specific gene delivery to extra-hepatic tissues and cells, including disseminated metastatic cancer cells. |
| FILED | Tuesday, June 07, 2022 |
| APPL NO | 17/805825 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/76 (20130101) A61K 35/761 (20130101) A61K 48/00 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 43/00 (20180101) Peptides C07K 14/005 (20130101) C07K 14/075 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 7/06 (20130101) C12N 15/86 (20130101) C12N 15/8616 (20130101) C12N 2710/00043 (20130101) C12N 2710/00061 (20130101) C12N 2710/10021 (20130101) C12N 2710/10322 (20130101) C12N 2710/10332 (20130101) C12N 2710/10333 (20130101) C12N 2710/10334 (20130101) C12N 2710/10345 (20130101) C12N 2810/405 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230001020 | Lagor et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Baylor College of Medicine (Houston, Texas) |
| ASSIGNEE(S) | Baylor College of Medicine (Houston, Texas) |
| INVENTOR(S) | William Lagor (Houston, Texas); Ayrea Hurley (Houston, Texas); Kelsey Jarrett (Houston, Texas); Karl-Dimiter Bissing (Houston, Texas); Marco De Giorgi (Houston, Texas); Mia Furgurson (Houston, Texas) |
| ABSTRACT | Embodiments of the disclosure encompass systems, methods, and compositions related to selective advantages to somatic cells that harbor one or more particular genetic modifications. In particular embodiments, there is selective expansion of gene-targeted cells wherein the strategy involves deletion of an essential gene product that is replaced with targeted integration that also includes integration of a therapeutic transgene. The cells that harbor the replaced essential gene product, and thereby the therapeutic transgene, are selected for using pharmaceutical or nutritional agents that are linked to the function of the essential gene product. |
| FILED | Friday, November 20, 2020 |
| APPL NO | 17/756242 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/0066 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0006 (20130101) C12N 9/22 (20130101) C12N 9/1085 (20130101) C12N 15/11 (20130101) C12N 15/86 (20130101) C12N 15/113 (20130101) C12N 2310/14 (20130101) C12N 2310/20 (20170501) C12N 2310/531 (20130101) C12N 2750/14143 (20130101) C12N 2750/14171 (20130101) C12N 2800/80 (20130101) Enzymes C12Y 101/01088 (20130101) C12Y 205/01087 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230001027 | Shively et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | City of Hope (Duarte, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John E. Shively (Arcadia, California); Michael R. Weist (Santa Ana, California); Bradley J. Ahrens (San Diego, California); Lin Li (Monrovia, California); Weidong Hu (Diamond Bar, California) |
| ABSTRACT | Provided herein, inter alia, are methods and compositions for detection of vascular calcification. |
| FILED | Wednesday, September 30, 2020 |
| APPL NO | 17/764708 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/0482 (20130101) Original (OR) Class A61K 51/0489 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230001400 | Goodson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Trustees of Southern Illinois University (Carbondale, Illinois); Vanderbilt University (Nashville, Tennessee); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | Board of Trustees of Southern Illinois University (Carbondale, Illinois); Vanderbilt University (Nashville, Tennessee); The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Boyd M. Goodson (Carbondale, Illinois); Eduard Y. Chekmenev (Troy, Michigan); Igor V. Koptyug (Novosibirsk, Russian Federation); Kirill V. Kovtunov (Novosibirsk, Russian Federation); Roman V. Shchepin (Nashville, Tennessee); Bryce E. Kidd (Carbondale, Illinois); Jonathan Gesiorski (Hickory Hills, Illinois); Max E. Gemeinhardt (Carbondale, Illinois); Danila A. Barskiy (Berkeley, California) |
| ABSTRACT | The present disclosure provides a method that embodies a simple and effective route to remove homogeneous catalysts from solutions wherein NMR/MRI signal amplification by reversible exchange (SABRE) or parahydrogen-induced polarization (PHIP) is performed. A method for recovering a homogeneous SABRE/PHIP catalyst for reuse is also described. |
| FILED | Monday, February 17, 2020 |
| APPL NO | 16/792637 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/1616 (20130101) B01J 31/2273 (20130101) B01J 31/2295 (20130101) B01J 31/4038 (20130101) Original (OR) Class B01J 38/02 (20130101) B01J 38/68 (20130101) B01J 2531/827 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002328 | Thompson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul R. Thompson (Wellesley, Massachusetts); Santanu Mondal (Shrewsbury, Massachusetts) |
| ABSTRACT | The invention provides novel inhibitors or inactivators of protein arginine deiminase 1, pharmaceutical compositions and methods of use thereof. The invention also relates to molecular probes based on such compounds and methods of use thereof. |
| FILED | Friday, June 26, 2020 |
| APPL NO | 17/622200 |
| CURRENT CPC | Heterocyclic Compounds C07D 235/16 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002329 | DISNEY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California) |
| ASSIGNEE(S) | The University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| INVENTOR(S) | Matthew David DISNEY (Jupiter, Florida); Jessica L. CHILDS-DISNEY (Jupiter, Florida) |
| ABSTRACT | Small molecule compounds and corresponding dimers having inhibitory activity against pre-miR-21 RNA and related methods for treatment of neoplastic disease such as cancer and especially cancers expressing miR-21 are disclosed. |
| FILED | Thursday, October 29, 2020 |
| APPL NO | 17/755105 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 235/18 (20130101) Original (OR) Class C07D 333/36 (20130101) C07D 403/14 (20130101) C07D 409/14 (20130101) Peptides C07K 7/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002335 | Tepe et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jetze J. Tepe (East Lansing, Michigan); Theresa A. Lansdell (East Lansing, Michigan); Evert Njomen (Ypsilanti, Michigan); Corey Lee Jones (Madison, Wisconsin) |
| ABSTRACT | The disclosure is directed to compounds of the formula (I) and (II) and uses of such compounds to treat, among other conditions, neurodegenerative diseases and cancers. |
| FILED | Monday, February 14, 2022 |
| APPL NO | 17/671480 |
| CURRENT CPC | Heterocyclic Compounds C07D 279/22 (20130101) Original (OR) Class C07D 417/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002381 | CHEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yu CHEN (Tampa, Florida); Michael SACCO (Tampa, Florida); James LEAHY (Tampa, Florida); Elena BRAY (Tampa, Florida); Xingmin SUN (Tampa, Florida); Xiujun ZHANG (Tampa, Florida) |
| ABSTRACT | Disclosed herein are compounds that can prevent and treat C. difficile by inhibiting sporulation. Also disclosed herein are compositions and formulations comprising the compound disclosed herein. Methods of preventing and treating C. difficile comprising administering the compounds described herein are also disclosed. |
| FILED | Monday, June 27, 2022 |
| APPL NO | 17/850650 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Heterocyclic Compounds C07D 471/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002383 | Canney et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Temple University-Of The Commonwealth System of Higher Education (Philadelphia, Pennsylvania); Praeventix, LLC (Exton, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel J. Canney (Ambler, Pennsylvania); Benjamin E. Blass (Eagleville, Pennsylvania); Kevin M. Blattner (Folsom, Pennsylvania); Douglas A. Pippin (Chester Springs, Pennsylvania) |
| ABSTRACT | Described herein are new, selective modulators of the 5-HT7 receptor. These selective compounds can be useful for the treatment of CNS and non-CNS indications. Compounds described herein can be selective in targeting 5-HT7 receptors as compared to other receptors and/or by selective targeting 5-HT7 receptors expressed in certain tissues or organs, thereby effective selectivity through a particular partitioning profile of the 5-HT7 modulator. |
| FILED | Thursday, November 12, 2020 |
| APPL NO | 17/776533 |
| CURRENT CPC | Heterocyclic Compounds C07D 403/06 (20130101) C07D 471/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002397 | Gray et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| INVENTOR(S) | Nathanael S. Gray (Stanford, California); Hu Liu (Newton, Massachusetts); Tinghu Zhang (Brookline, Massachusetts); Lyn Howard Jones (Winchester, Massachusetts); Jianwei Che (Sharon, Massachusetts) |
| ABSTRACT | Disclosed are compounds and pharmaceutically acceptable salts, hydrates, solvates, prodrugs, stereoisomers, or tautomers thereof that may cause degradation of various proteins e.g., IKZF2 (Helios). Also disclosed are pharmaceutical compositions containing same, and methods of making and using the compounds to treat diseases and disorders associated with Helios and which may benefit from Helios degradation. |
| FILED | Thursday, October 29, 2020 |
| APPL NO | 17/772384 |
| CURRENT CPC | Heterocyclic Compounds C07D 401/14 (20130101) C07D 405/14 (20130101) C07D 413/14 (20130101) C07D 417/14 (20130101) C07D 419/14 (20130101) C07D 471/04 (20130101) C07D 487/08 (20130101) C07D 487/10 (20130101) Original (OR) Class C07D 491/107 (20130101) C07D 498/08 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/65583 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002442 | Liu |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wenshe Liu (College Station, Texas) |
| ABSTRACT | Embodiments of the present disclosure pertain to methods of conjugating a molecule to a polypeptide by (1) modifying one or more thiol residues on the polypeptide, where the modifying includes cyanylation of the one or more thiol residues; and (2) associating the polypeptide with the molecule, where the associating results in the conjugation of the molecule to the polypeptide through a reaction between a nucleophilic moiety on the molecule and the one or more modified thiol residues. The cyanylation may include attachment of cyano groups to sulfur atoms of the one or more thiol residues to form thiocyanato groups that undergo reversible intramolecular addition with a nearby N-amide group to generate a 1-acyl-2-iminothiazolidine intermediate. Thereafter, the nucleophilic moiety on the molecule reacts with the 1-acyl-2-iminothiazolidine intermediate to replace 2-iminothiazolidine in a nucleophilic acyl substitution reaction and result in the conjugation of the molecule to the polypeptide. |
| FILED | Friday, January 03, 2020 |
| APPL NO | 17/783639 |
| CURRENT CPC | Peptides C07K 1/10 (20130101) C07K 1/1077 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002451 | KELSIC et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Eric KELSIC (Cambridge, Massachusetts); Sam SINAI (Somerville, Massachusetts); Pierce OGDEN (Somerville, Massachusetts); George M. CHURCH (Brookline, Massachusetts) |
| ABSTRACT | The technology described herein provides variant adeno-associated viral capsid polypeptides and viruses comprising the same. Further provided herein are methods for delivering a viral payload using viruses comprising variant capsid polypeptides described herein. |
| FILED | Friday, November 06, 2020 |
| APPL NO | 17/774306 |
| CURRENT CPC | Peptides C07K 14/075 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/861 (20130101) C12N 2750/14122 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002467 | Garcia et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher K. Garcia (Menlo Park, California); Suman Mitra (Bethesda, Maryland); Warren J. Leonard (Bethesda, Maryland); Aaron M. Ring (Palo Alto, California) |
| ABSTRACT | Novel human interleukin-2 (IL-2) muteins or variants thereof are provided. In particular, provided are IL-2 muteins that have an increased binding capacity for IL-2Rβ receptor and a decreased binding capacity for IL-2Rγc receptor, as compared to wild-type IL-2. Such IL-2 muteins are useful, for example, as IL-2 partial agonist and antagonists in applications where reduction or inhibition of one or more IL-2 and/or IL-15 functions is useful (e.g., in the treatment of graft versus host disease (GVHD) and adult T cell leukemia). Also provided are nucleic acids encoding such IL-2 muteins, methods of making such IL-2 muteins, pharmaceutical compositions that include such IL-2 muteins and methods of treatment using such pharmaceutical compositions. |
| FILED | Thursday, May 26, 2022 |
| APPL NO | 17/825660 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/55 (20130101) Original (OR) Class C07K 2319/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002480 | Sajadi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Dongkyoon Kim (Palo Alto, California); Guy Cavet (Hillsborough, California); University of Maryland, Baltimore (Baltimore, Maryland); The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mohammad Sajadi (Cockeysville, Maryland); George K. Lewis (Baltimore, Maryland); Anthony DeVico (Alexandria, Virginia); Dongkyoon Kim (Palo Alto, California); Guy Cavet (Hillsborough, California) |
| ABSTRACT | The present invention provides broadly neutralizing antibodies against HIV, compositions comprising the same and methods of use thereof. |
| FILED | Tuesday, February 22, 2022 |
| APPL NO | 17/677757 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/42 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Peptides C07K 16/1045 (20130101) C07K 16/1063 (20130101) Original (OR) Class C07K 2317/34 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/94 (20130101) C07K 2317/565 (20130101) C07K 2317/732 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002491 | ZANG |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Albert Einstein College of Medicine (Bronx, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xingxing ZANG (New York, New York) |
| ABSTRACT | Provided are methods of treating an autoimmune disease in a subject, or of suppressing transplant rejection in a subject, or of treating a cancer in a subject, as well as compositions therefor. |
| FILED | Monday, January 24, 2022 |
| APPL NO | 17/648792 |
| CURRENT CPC | Peptides C07K 16/2827 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/24 (20130101) C07K 2319/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002709 | Breuer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Research Institute at Nationwide Children's Hospital (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Breuer (Columbus, Ohio); Cameron Best (Columbus, Ohio); Robert Strouse (Columbus, Ohio); James Reinhardt (Columbus, Ohio) |
| ABSTRACT | Closed disposable seeding systems with improved seeding chambers permitting uniform seeding of a scaffold or graft with patient's cells are provided. The seeding chambers with a variable width along the length of the chamber, or a minimal gap between the scaffold and chamber wall, provide an improvement of the prior seeding chambers of closed disposable seeding systems by providing faster and more efficient and uniform seeding of the grafts and scaffolds. Also described are scaffolds with biomechanical and structural properties permitting spontaneous reversal of stenosis and neotissue formation as the graft degrades yielding a scaffold-free neovessel. |
| FILED | Monday, November 16, 2020 |
| APPL NO | 17/776912 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) A61L 27/20 (20130101) A61L 27/34 (20130101) A61L 27/54 (20130101) A61L 27/56 (20130101) A61L 27/507 (20130101) A61L 27/3804 (20130101) A61L 2300/41 (20130101) A61L 2300/222 (20130101) A61L 2300/414 (20130101) A61L 2300/416 (20130101) A61L 2300/426 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 80/00 (20141201) Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) Original (OR) Class C12M 23/38 (20130101) C12M 25/14 (20130101) C12M 29/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002723 | Taylor et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Doris Taylor (St. Paul, Minnesota); Stefan M. Kren (Minneapolis, Minnesota) |
| ABSTRACT | Described herein are methods of recellularizing an organ or tissue matrix. |
| FILED | Wednesday, July 06, 2022 |
| APPL NO | 17/858960 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/3604 (20130101) A61L 27/3808 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0062 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002727 | Fan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Allegheny Singer Research Institute (Pittsburgh, Pennsylvania); University of Pittsburgh - of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yong Fan (Pittsburgh, Pennsylvania); Ann Zeleniak (Pittsburgh, Pennsylvania); Massimo Trucco (Pittsburgh, Pennsylvania); Ipsita Banerjee (Pittsburgh, Pennsylvania) |
| ABSTRACT | This document relates to bioengineering and involves bioengineered thymus organoids and related humanized animal models. The thymus organoids and animal models have various commercial and clinical uses, including generating humanized antibodies, making antigen-specific human T cells, inducing transplantation tolerance, rejuvenating thymus functions, and modeling human diseases. |
| FILED | Wednesday, November 25, 2020 |
| APPL NO | 17/756398 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0278 (20130101) A01K 2207/12 (20130101) A01K 2217/15 (20130101) A01K 2227/105 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 35/26 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0012 (20130101) C12N 5/065 (20130101) Original (OR) Class C12N 5/0647 (20130101) C12N 5/0697 (20130101) C12N 2501/15 (20130101) C12N 2501/16 (20130101) C12N 2501/125 (20130101) C12N 2501/145 (20130101) C12N 2501/155 (20130101) C12N 2506/45 (20130101) C12N 2513/00 (20130101) C12N 2533/74 (20130101) C12N 2533/90 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002728 | Palecek et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sean Palecek (Verona, Wisconsin); Gyuhyung Jin (Madison, Wisconsin) |
| ABSTRACT | This disclosure relates generally to the differentiation of human pluripotent stem cells, and more particularly to a method of spatially adsorbing morphogens to differentiate human pluripotent stem cells. |
| FILED | Friday, July 01, 2022 |
| APPL NO | 17/856653 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0606 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/4833 (20130101) G01N 33/5044 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002736 | Mattis |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF ATHE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aras N. Mattis (San Francisco, California) |
| ABSTRACT | Provided are methods for inducing differentiation of pluripotent stem cells, e.g., induced pluripotent stem cells, to form definitive endoderm. Also provided are methods for producing more committed endodermal cells such as hepatoblasts or hepatocytes. |
| FILED | Friday, December 11, 2020 |
| APPL NO | 17/783574 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0672 (20130101) Original (OR) Class C12N 2501/16 (20130101) C12N 2506/45 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002738 | Soo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of The University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | B. Chia Soo (Los Angeles, California); Kang Ting (Los Angeles, California); Zhong Zheng (Van Nuys, California) |
| ABSTRACT | The present invention provides a method of treating a disorder using a fibromodulin (FMOD) reprogrammed (FReP) cell. The method comprises administering locally to a human being the FReP cell to a site in need thereof of the human being. |
| FILED | Thursday, February 24, 2022 |
| APPL NO | 17/679745 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/00 (20130101) A61K 35/12 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0607 (20130101) C12N 5/0696 (20130101) Original (OR) Class C12N 2506/1307 (20130101) C12N 2510/00 (20130101) C12N 2533/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002742 | Steinmetz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicole Steinmetz (San Diego, California); Daniel Popkin (Cleveland, Ohio) |
| ABSTRACT | A method of non-covalently loading a plant picornavirus is described. The method includes contacting a plant picornavirus in solution with a molar excess of a cargo molecule to load the plant picornavirus with the cargo molecule, and then purifying the loaded plant picornavirus. Examples of cargo molecules include imaging agents, antitumor agents, and antiviral agents. Loaded plant picornaviruses prepared in this manner can be used to delivering cargo molecule to cells. |
| FILED | Tuesday, June 28, 2022 |
| APPL NO | 17/851187 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/40 (20130101) A61K 31/473 (20130101) A61K 33/243 (20190101) A61K 35/76 (20130101) A61K 47/46 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class C12N 2770/32041 (20130101) C12N 2770/32042 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002745 | Kim et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Yongjoo Kim (Cambridge, Massachusetts); David R. Liu (Cambridge, Massachusetts); Kevin Tianmeng Zhao (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein are compositions, systems, and methods for delivering an effector protein into a cell. The present disclosure, in some aspects, provide novel proteins delivering an effector protein into a cell. The novel proteins are supernegatively charged proteins derived from highly anionic proteins identified from the proteome (e.g., human proteome). The novel protein tags can be associated (e.g., covalently or nocovalently) with the protein to be delivered to facilitate delivery of the effector protein into a cell. |
| FILED | Thursday, January 23, 2020 |
| APPL NO | 17/425261 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5123 (20130101) A61K 38/00 (20130101) Peptides C07K 14/4702 (20130101) C07K 14/4728 (20130101) C07K 14/57581 (20130101) C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 9/78 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002753 | Ranum et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| INVENTOR(S) | Laura Ranum (Gainesville, Florida); Tao Zu (Gainesville, Florida) |
| ABSTRACT | Methods and compositions for modulating repeat non-ATG protein (RAN protein) translation are provided. In some aspects, the disclosure provides methods of inhibiting RAN protein translation by contacting a cell with an effective amount of an inhibitor of eIF2 phosphorylation or an inhibitor of protein kinase R (PKR). In some embodiments, methods described by the disclosure are useful for treating diseases associated with RAN protein translation, such as certain neurodegenerative diseases. |
| FILED | Friday, May 27, 2022 |
| APPL NO | 17/826224 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) A61K 31/7105 (20130101) A61K 35/761 (20130101) A61K 38/45 (20130101) Peptides C07K 14/47 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/66 (20130101) C12N 15/102 (20130101) Original (OR) Class C12N 2750/14143 (20130101) Enzymes C12Y 207/01037 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002774 | Cheng et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kai-Wen Cheng (Pasadena, California); Shan Li (Pasadena, California); Feng Wang (Pasadena, California); Tsui-Fen Chou (San Marino, California) |
| ABSTRACT | Provided herein are methods and compositions for inhibiting p97, for the treatment of a coronavirus infection in a subject, or a symptom thereof. Upon treatment, the coronavirus infection, or a symptom thereof is reduced in the subject. |
| FILED | Friday, June 24, 2022 |
| APPL NO | 17/849132 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/403 (20130101) A61K 31/496 (20130101) A61K 31/517 (20130101) A61K 31/519 (20130101) A61K 31/538 (20130101) A61K 31/4439 (20130101) A61K 31/7088 (20130101) A61K 38/465 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/40 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/14 (20130101) C12N 2310/531 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002776 | Kochenderfer |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | James N. Kochenderfer (Bethesda, Maryland) |
| ABSTRACT | The invention provides an isolated and purified nucleic acid sequence encoding a chimeric antigen receptor (CAR) directed against B-cell Maturation Antigen (BCMA). The invention also provides host cells, such as T-cells or natural killer (NK) cells, expressing the CAR and methods for destroying multiple myeloma cells. |
| FILED | Monday, May 16, 2022 |
| APPL NO | 17/745067 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) Peptides C07K 14/7051 (20130101) C07K 14/70503 (20130101) C07K 14/70517 (20130101) C07K 14/70521 (20130101) C07K 14/70578 (20130101) C07K 16/18 (20130101) C07K 16/2878 (20130101) C07K 2319/03 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/62 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002785 | SANTAGELO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GEORGIA TECH RESEARCH CORPORATION (Atlanta, Georgia); ZABBIO, INC. (San Diego, California) |
| ASSIGNEE(S) | GEORGIA TECH RESEARCH CORPORATION (Atlanta, Georgia); ZABBIO, INC. (San Diego, California) |
| INVENTOR(S) | Philip J. SANTAGELO (Smyrna, Georgia); Daryll VANOVER (Duluth, Georgia); Kevin J. WHALEY (San Diego, California) |
| ABSTRACT | Non-hormonal contraception compositions and methods for contraception are provided. One embodiment provides an antibody or an antigen binding fragment thereof that specifically binds to one or more sperm antigens and inhibits the ability of anti-body-bound sperm to fertilize an egg. Typically, the antibody is a monoclonal antibody, for example a human or humanized monoclonal antibody. In one embodiment, the antibody or antigen binding fragment thereof specifically binds to CD52g expressed on vertebrate, for example human, sperm cells and inhibits, blocks, or reduces the ability of the antibody-bound sperm to fertilize an egg. In one embodiment the antibody contains a membrane anchor. The membrane anchor can contain transmembrane domains, glycosylphosphatidylinositol anchors, or myristoylation motifs. |
| FILED | Wednesday, October 28, 2020 |
| APPL NO | 17/772932 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/12 (20130101) A61K 9/0034 (20130101) A61K 35/54 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 15/18 (20180101) Peptides C07K 16/2893 (20130101) C07K 2319/035 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002786 | Samulski |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard Jude Samulski (Hillsborough, North Carolina) |
| ABSTRACT | The present invention provides methods and compositions comprising an adeno-associated vims (AAV) synthetic inverted terminal repeat (ITR), wherein the ITR may have modified promoter transcriptional function. Additionally provided are vectors and virus particles comprising the same, as well as methods of their use. |
| FILED | Thursday, January 07, 2021 |
| APPL NO | 17/791303 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/0066 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 2750/14122 (20130101) C12N 2750/14123 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002788 | Wilson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James M. Wilson (Philadelphia, Pennsylvania); Qiang Wang (Philadelphia, Pennsylvania) |
| ABSTRACT | Provided herein are novel AAV capsids and rAAV comprising the same. In one embodiment, vectors employing the AAV capsid show increased transduction in a selected tissue as compared to a prior art AAV. |
| FILED | Tuesday, October 20, 2020 |
| APPL NO | 17/770138 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/861 (20130101) Original (OR) Class C12N 2750/14122 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002790 | Green et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jordan J. Green (Nottingham, Maryland); David Wilson (Smithsburg, Maryland); Yuan Rui (Baltimore, Maryland); Donald J. Zack (Baltimore, Maryland); Srinivasa Rao Sripathi (Baltimore, Maryland); Cynthia A. Berlinicke (Baltimore, Maryland) |
| ABSTRACT | Biodegradable particles for delivering a nucleic acid encoding gene-editing factors or a nucleic acid associated with a therapeutic protein to a cell, and compositions, methods, systems, and kits for gene editing in vivo or ex vivo or gene therapy for treating retinal eye diseases are disclosed. |
| FILED | Thursday, October 10, 2019 |
| APPL NO | 17/282939 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 69/26 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/88 (20130101) Original (OR) Class C12N 15/111 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002799 | Tossberg et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John T. Tossberg (Nashville, Tennessee); Thomas M. Aune (Nashville, Tennessee) |
| ABSTRACT | Disclosed are methods for preparing mRNA and proteins from synthetic DNA. |
| FILED | Friday, December 11, 2020 |
| APPL NO | 17/784816 |
| CURRENT CPC | Peptides C07K 14/5406 (20130101) C07K 14/5434 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Original (OR) Class C12P 21/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002809 | Samusik et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nikolay Samusik (Jacksonville, Oregon); Garry P. Nolan (Redwood City, California); Yury Goltsev (Stanford, California) |
| ABSTRACT | A method for analyzing planar sample is provided. In some cases the method comprises: (a) incubating the planar sample with a capture agent that is linked to an oligonucleotide, wherein the capture agent specifically binds to complementary sites in the planar sample; (b) reading a fluorescent signal caused by extension of a primer that is hybridized to the oligonucleotide, using fluorescence microscopy. Several implementations of the method, and multiplexed versions of the same, are also provided. |
| FILED | Tuesday, February 15, 2022 |
| APPL NO | 17/672552 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6804 (20130101) C12Q 1/6818 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002831 | Velculescu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Victor Velculescu (Dayton, Maryland); Alessandro Leal (Baltimore, Maryland); Jillian Phallen (Baltimore, Maryland); Valsamo Anagnostou (Baltimore, Maryland); Remond Fijneman (Amsterdam, Netherlands); Gernt Meijer (Amsterdam, Netherlands); Nicole Van Grieken (Amsterdam, Netherlands) |
| ABSTRACT | Combined ultrasensitive sequencing of matched white blood cells and cell free DNA (cfDNA) identified bona fide tumor-specific alterations that predict clinical outcome after preoperative treatment and resection. |
| FILED | Wednesday, November 25, 2020 |
| APPL NO | 17/779936 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/156 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/20 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230003721 | DAVIS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ronald L. DAVIS (Palm Beach, Florida); Ze LIU (Jupiter, Florida); Boglarka H. VARKUTI (Balatonalmadi, Hungary); Miklos KEPIRO (Siklos, Hungary); Courtney M. MACMULLEN (Palm City, Florida); The University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ronald L. DAVIS (West Palm Beach, Florida); Ze LIU (Jupiter, Florida); Boglarka H. VARKUTI (Balatonalmadi, Hungary); Miklos KEPIRO (Siklos, Hungary); Courtney M. MACMULLEN (Palm City, Florida) |
| ABSTRACT | Described herein is a multiplexed and high content screening assay using primary neurons for identifying small molecule modulators of neuronal mitochondrial mitostasis (MnMs). Also described is a high throughput screening assay using primary neurons for identifying small molecules that increase mitochondrial function, identified by measuring the electrochemical potential across the inner mitochondrial membrane and ATP generation. Most MnMs that increased mitochondrial content, length and/or health also increased mitochondrial function without altering neurite outgrowth. Some MnMs protect mitochondria in primary neurons from Aβ(1-42) toxicity, glutamate toxicity, increased oxidative stress and the toxic cellular environment associated with Alzheimer's disease. Some MnMs target mitochondria directly. An MnM also increases the synaptic activity of hippocampal neurons and is potent in vivo, increasing the respiration rate of brain mitochondria after administering the compound to mice. The MnMs were demonstrated to protect the mitochondrial population in neurons in an in vivo model of Alzheimer's Disease. Also described is a method for treating a patient suffering from a disorder characterized by dysfunction of neuronal mitostasis, comprising administering to the patient a therapeutically effective amount of a compound (MnM), or a pharmaceutically acceptable salt thereof. |
| FILED | Tuesday, November 24, 2020 |
| APPL NO | 17/756842 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/12 (20130101) A61K 31/137 (20130101) A61K 31/138 (20130101) A61K 31/245 (20130101) A61K 31/353 (20130101) A61K 31/403 (20130101) A61K 31/451 (20130101) A61K 31/454 (20130101) A61K 31/475 (20130101) A61K 31/495 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5058 (20130101) Original (OR) Class G01N 33/5079 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230003730 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Xin Wei Wang (Rockville, Maryland); Jinping Liu (Wynnewood, Pennsylvania); Wei Tang (Bethesda, Maryland) |
| ABSTRACT | A viral exposure signature (VES) that can identify early stage, pre-symptomatic hepatocellular carcinoma (HCC) among at-risk patients is described. The VES was developed using serological profiling and synthetic virome technology to identify unique viral peptide epitopes corresponding to 61 viral species. Methods of identifying a subject with early stage (pre-symptomatic) HCC using the VES are described. |
| FILED | Friday, October 09, 2020 |
| APPL NO | 17/766015 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1037 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 40/02 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) Original (OR) Class G01N 33/57438 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230003732 | GUTIERREZ et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| INVENTOR(S) | Alejandro GUTIERREZ (Brookline, Massachusetts); Laura HINZE (Bueckeburg, Germany) |
| ABSTRACT | Described herein are methods and compositions for treating cancer. Aspects of the invention relate to determining if a biological sample obtained from a subject for GSK3a bodies (puncta), e.g., in response to asparaginase treatment, and administering to a subject having cancer an asparaginase and an agent that inhibits GSK3α to a subject who has been identified as forming GSK3α-positive bodies. |
| FILED | Tuesday, November 03, 2020 |
| APPL NO | 17/773233 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/437 (20130101) A61K 31/713 (20130101) A61K 31/7105 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/82 (20130101) Enzymes C12Y 305/01001 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57484 (20130101) Original (OR) Class G01N 2333/91215 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230003733 | LILES et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | FRED HUTCHINSON CANCER CENTER (Seattle, Washington); UNIVERSITY OF WASHINGTON (Seattle, Washington); BLOODWORKS NORTHWEST (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | W. Conrad LILES (Seattle, Washington); Cameron J. TURTLE (Seattle, Washington); David G. MALONEY (Issaquah, Washington); Stanley R. RIDDELL (Sammamish, Washington); Mark M. WURFEL (Seattle, Washington); Jose LOPEZ (Seattle, Washington); Dominic CHUNG (Bellevue, Washington); Junmei CHEN (Seattle, Washington) |
| ABSTRACT | The instant disclosure provides biomarkers and methods for identifying subjects at risk of developing cytokine release syndrome (CRS), neurotoxicity, or both after adoptive immunotherapy to guide preemptive intervention, modified therapy, or the like. For example, adverse event biomarkers may be measured in a subject before pre-conditioning chemotherapy, before immunotherapy (e.g., adoptive immunotherapy infusion comprising a chimeric antigen receptor (CAR)-modified T cell), or shortly after pre-conditioning chemotherapy and/or immunotherapy. Exemplary biomarkers include temperature, cytokine levels and endothelial activation biomarkers, such as angiopoietin-2, von Willebrand factor (vWF), ratio of angiopoietin-2 to angiopoietin-1, and ratio of ADAMTS13 to vWF. Also provided are methods of treating subjects identified as at risk of developing cytokine release syndrome (CRS), neurotoxicity, or both to minimize such potential adverse events. |
| FILED | Wednesday, June 22, 2022 |
| APPL NO | 17/846966 |
| CURRENT CPC | Peptides C07K 16/22 (20130101) C07K 16/248 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57484 (20130101) Original (OR) Class G01N 2333/515 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 40/10 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230003741 | SMITH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sakima SMITH (New Albany, Ohio); Craig MCELROY (Lancaster, Ohio); Patrick DIB (Columbus, Ohio) |
| ABSTRACT | Disclosed are compositions and methods for determining aberrant cardiac function or a predisposition to aberrant cardiac function, said method comprising detecting a fragment of βII spectrin associated with aberrant cardiac function or a predisposition to aberrant cardiac function in a sample derived from a subject, wherein the detection is indicative of aberrant cardiac function in the subject. |
| FILED | Tuesday, November 24, 2020 |
| APPL NO | 17/780321 |
| CURRENT CPC | Peptides C07K 16/18 (20130101) C07K 2317/34 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5023 (20130101) G01N 33/6893 (20130101) Original (OR) Class G01N 2800/32 (20130101) G01N 2800/50 (20130101) G01N 2800/52 (20130101) G01N 2800/323 (20130101) G01N 2800/324 (20130101) G01N 2800/325 (20130101) G01N 2800/326 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230003743 | Chatila et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| INVENTOR(S) | Talal Amine Chatila (Belmont, Massachusetts); Elena Crestani (Brookline, Massachusetts); Emmanuel Stephen Victor (Karnataka, India); Azza Abdel-Gadir (Cambridge, Massachusetts); Rima Rachid (Belmont, Massachusetts) |
| ABSTRACT | Described herein are methods and compositions for treating or preventing an allergy or anaphylaxis. Certain aspects of the invention relate to administering to a subject an agent that inhibits RELMβ. |
| FILED | Tuesday, February 23, 2021 |
| APPL NO | 17/801238 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/08 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/74 (20130101) G01N 33/6893 (20130101) Original (OR) Class G01N 2333/575 (20130101) G01N 2800/24 (20130101) G01N 2800/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230003744 | Hu |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey); Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William T. Hu (New Brunswick, New Jersey) |
| ABSTRACT | Embodiments of the disclosure are directed to biomarkers, or a panel of biomarkers, that determine progression of Alzheimer's disease, and methods of use thereof. |
| FILED | Thursday, June 16, 2022 |
| APPL NO | 17/842433 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) Original (OR) Class G01N 2800/56 (20130101) G01N 2800/2821 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230004592 | Mostafa et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Javed Mostafa (Cary, North Carolina); Michael Segundo Ortiz (Chapel Hill, North Carolina); Kazuhiro Seki (Kobe, Japan); Mengqian Wang (Chapel Hill, North Carolina); Heejun Kim (Bryn Mawr, Pennsylvania) |
| ABSTRACT | The subject matter described herein relates to methods, systems, and computer readable media for dynamic cluster-based search and retrieval. An example method for dynamic cluster-based search and retrieval occurs at a server. The method includes: retrieving document data for a plurality of documents related to user input; performing keyword discovery on the document data for determining term related frequency metrics and document related frequency metrics; representing the plurality of documents as a term-document matrix based on the term related frequency metrics and the document related frequency metrics; reducing, using latent semantic analysis, the dimensionality of the matrix; clustering, using a k-means clustering algorithm and the dimensionally reduced matrix, the plurality of documents into clusters; and sending presentation information to a client device for displaying visual representations of the clusters, wherein each visual representation is associated with one or more of the plurality of documents. |
| FILED | Friday, September 02, 2022 |
| APPL NO | 17/902583 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/358 (20190101) Original (OR) Class G06F 16/3334 (20190101) G06F 40/30 (20200101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 70/60 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230005134 | MATTREY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Regents of The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | The Board of Regents of The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Robert F. MATTREY (Dallas, Texas); Caroline DE GRACIA LUX (Dallas, Texas); Jacques LUX (Dallas, Texas); Zhenghong GAO (Dallas, Texas); Carlos J. BRAMBILA (Dallas, Texas) |
| ABSTRACT | The disclosure describes imaging and therapy techniques comprising nanodroplets. More particularly, aspects of the disclosure relate to the use of nanodroplets to modify nanobubbles or microbubbles to provide improved imaging and/or therapeutic techniques and compositions. |
| FILED | Friday, May 13, 2022 |
| APPL NO | 17/744423 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 7/02 (20130101) A61N 2007/0039 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 7/62 (20170101) G06T 2207/20104 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230005145 | Madabhushi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anant Madabhushi (Shaker Heights, Ohio); Cristian Barrera (Bogota, Colombia); German Corredor (Bogota, Colombia); Eduardo Romero (Bogota, Colombia) |
| ABSTRACT | The present disclosure relates to an apparatus including one or more processors configured to receive a digitized image of a region of tissue demonstrating a disease, and containing cellular structures represented in the digitized image, each of the cellular structures being associated with a cell category of a plurality of cell categories; select a cellular structure of the cellular structures based on the cell category for the cellular structure; for the cellular structure selected, compute a set of contextual features; assign, based on the set of contextual features, the cellular structure to at least one cluster of a plurality of clusters; compute cluster features, the cluster features describing characteristics of the at least one cluster of the plurality of clusters; and generate a prediction that describes a pathologic or phenotypic state of the disease based, at least in part, on the cluster features and/or the set of contextual features. |
| FILED | Thursday, September 08, 2022 |
| APPL NO | 17/940243 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6228 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 2207/10056 (20130101) G06T 2207/20081 (20130101) G06T 2207/30024 (20130101) G06T 2207/30061 (20130101) G06T 2207/30096 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 40/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230005146 | Wick et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CAMERAD TECHNOLOGIES (Decatur, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carson A. Wick (Decatur, Georgia); Srini Tridandapani (Decatur, Georgia) |
| ABSTRACT | Methods for identifying a disease state in a patient and/or for treating a patient having the identified disease state are disclosed and can be based on characteristics identified through machine learning models such as deep learning convolutional neural networks and that are associated with video recordings, audio recordings, infrared images, photographs, and/or radiologic patient images. |
| FILED | Friday, September 09, 2022 |
| APPL NO | 17/941993 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230005147 | Wick et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CAMERAD TECHNOLOGIES (Decatur, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carson A. Wick (Decatur, Georgia); Srini Tridandapani (Decatur, Georgia) |
| ABSTRACT | A method for identifying a misidentified study can utilize a set of photographs captured at substantially the same time as a corresponding set of medical images. The method can include determining similarities between the photographs through machine learning models and determining that a misidentified study exists when the similarity between the photographs fails to satisfy a threshold similarity. |
| FILED | Friday, September 09, 2022 |
| APPL NO | 17/942026 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230005594 | ENDERLING et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Heiko ENDERLING (New Tampa, Florida); Rence BRADY-NICHOLLS (Riverview, Florida) |
| ABSTRACT | Disclosed are methods for personalized treatment of tumor lesions in subject following primary tumor treatment. Disclosed are methods related to using patient specific prostate cancer dynamic model to adjust a patient's intermittent androgen deprivation therapy to determine when to pause IADT, when to resume IADT, the amount of treatment, and the rate of treatment and thereby increasing the time to progression of the tumor and thus prolonging post cancer treatment survival. |
| FILED | Monday, December 07, 2020 |
| APPL NO | 17/782897 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/58 (20130101) A61K 31/337 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/30 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/40 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20230000339 | O'BRIEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Kevin John O'BRIEN (Fort Rucker, Alabama); Victor Alan ESTES (Fort Rucker, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin John O'BRIEN (Fort Rucker, Alabama); Victor Alan ESTES (Fort Rucker, Alabama) |
| ABSTRACT | A glare source device, a glare test system and methods that assesses visual performance and discomfort under varying levels of glare under varying lighting conditions is provided. |
| FILED | Friday, February 21, 2020 |
| APPL NO | 17/432007 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/032 (20130101) Original (OR) Class A61B 3/063 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230000869 | Yu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Brigham and Women's Hospital, Inc. (Boston, Massachusetts); The United States of America, as Represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul B. Yu (Boston, Massachusetts); Wenwei Huang (Rockville, Maryland); Philip Edward Sanderson (Bethesda, Maryland); Jian-Kang Jiang (Columbia, Maryland); Khalida Shamim (Gaithersburg, Maryland); Wei Zheng (Potomac, Maryland); Xiuli Huang (Potomac, Maryland); Gregory Tawa (Doylestown, Pennsylvania); Arthur Lee (San Jose, California); Asaf Alimardanov (North Bethesda, Maryland); Junfeng Huang (Woodstock, Maryland) |
| ABSTRACT | The present invention provides small-molecule inhibitors of BMP signaling and compositions and methods for inhibiting BMP signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds and compositions may also be used to treat subjects with Sjögren's syndrome, or diffuse intrinsic pontine glioma (DIPG). |
| FILED | Monday, June 07, 2021 |
| APPL NO | 17/340589 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) Original (OR) Class A61K 31/551 (20130101) A61K 31/675 (20130101) A61K 31/5377 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/08 (20180101) Heterocyclic Compounds C07D 487/04 (20130101) C07D 519/00 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/6561 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230000881 | Zuo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | St. Jude Children's Research Hospital (Memphis, Tennessee) |
| ASSIGNEE(S) | St. Jude Children's Research Hospital (Memphis, Tennessee) |
| INVENTOR(S) | Jian Zuo (Omaha, Nebraska); Tal Teitz (Omaha, Nebraska); Fang Jie (Memphis, Tennessee); Goktug Asli (Memphis, Tennessee); Chen Taosheng (Germantown, Tennessee); Min Jaeki (Memphis, Tennessee); R. Kiplin Guy (Memphis, Tennessee) |
| ABSTRACT | In one aspect, pharmaceutical compositions comprising a CDK2 inhibitor and one or more of at least one agent known to treat a hearing impairment and at least one agent known to prevent a hearing impairment, and methods of treating and/or preventing hearing impairments or disorders using the compositions are disclosed. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| FILED | Tuesday, July 12, 2022 |
| APPL NO | 17/862656 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/52 (20130101) A61K 31/55 (20130101) Original (OR) Class A61K 31/404 (20130101) A61K 31/454 (20130101) A61K 31/506 (20130101) A61K 31/519 (20130101) A61K 31/4015 (20130101) A61K 31/4155 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/16 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230000979 | Bornholdt et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Albert Einstein College of Medicine (Bronx, New York); Adimab, LLC (Lebanon, New Hampshire); Mapp Biopharmaceutical, Inc. (San Diego, California); Board of Regents, The University of Texas System (Austin, Texas); The Government of the United States, as represented by the Secretary of the Army (Frederick, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zachary A. Bornholdt (Encinitas, California); Akaash Mishra (Austin, Texas); Laura M. Walker (Norwich, Vermont); Noel T. Pauli (Lebanon, New Hampshire); Daniel Maurer (Cambridge, Massachusetts); Kartik Chandran (Bronx, New York); Jens Maximilian Fels (Bronx, New York); Dafna Abelson (San Diego, California); Jason Scott McLellan (Austin, Texas); Jonathan R. Lai (Bronx, New York); Ariel Wirchnianski (Bronx, New York); Olivia Vergnolle (Bronx, New York); John M. Dye (Frederick, Maryland); Andrew S. Herbert (Frederick, Maryland) |
| ABSTRACT | Anti-CCHFV antibodies with neutralizing potency and protective efficacy against CCHFV are provided, as well as methods for their identification, isolation, generation, and methods for their preparation and use are provided. |
| FILED | Tuesday, May 31, 2022 |
| APPL NO | 17/829164 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/42 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230001017 | Salem et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of lowa Research Foundation (Iowa City, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aliasger K. Salem (Coralville, Iowa); James A. Martin (Iowa City, Iowa); Leela Raghava Jaidev Chakka (Iowa City, Iowa); Juliana c. Quarterman (Coralville, Iowa); Hongjun Zheng (St. Louis, Missouri); Dong Rim Seol (lowa City, Iowa) |
| ABSTRACT | Compositions comprising nanoparticles, nanoplexes or virus comprising isolated nucleic acid comprising nucleic acid encoding a mammalian, and methods of using the compositions, are provided. |
| FILED | Wednesday, October 28, 2020 |
| APPL NO | 17/772450 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/005 (20130101) Original (OR) Class A61K 48/0008 (20130101) Peptides C07K 14/4713 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230001054 | King et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE CHARLES STARK DRAPER LABORATORY, INC. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Frederick King (Watertown, Massachusetts); David J. Carter (Concord, Massachusetts); Corin Williams (Framingham, Massachusetts); Stephanie Lynne Golmon (Arlington, Massachusetts) |
| ABSTRACT | A biocompatible adhesive is disclosed. The biocompatible adhesive includes a substrate and a plurality of micro-scale elements extending from a surface of the substrate having a length selected to puncture a layer of a target tissue or target material. At least some of the micro-scale elements include at least one protrusion dimensioned to anchor the biocompatible adhesive to the target tissue or target material. A medical device assembly is also disclosed. The medical device assembly includes the biocompatible adhesive coupled to a surface of a component of the medical device assembly and positioned to attach the medical device assembly to the target tissue or target material. A method of facilitating attachment of a medical device assembly to a target tissue is also disclosed. A method of facilitating treatment of a wound is also disclosed. |
| FILED | Thursday, June 30, 2022 |
| APPL NO | 17/855081 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/50 (20130101) Original (OR) Class A61L 27/54 (20130101) A61L 2400/18 (20130101) A61L 2430/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230001141 | FRANKLIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Prytime Medical Devices, Inc. (Boerne, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Curtis J. FRANKLIN (Lakewood, Colorado); David SPENCER (Boerne, Texas); Todd J. KRUMMENACHER (Lakewood, Colorado) |
| ABSTRACT | An occlusion catheter system includes a proximal hub having an inflation connection port and an inflation pathway. An inflation catheter member is connected to the proximal hub and has an inflation lumen. A stiffener member defines a longitudinal axis. The proximal end of the stiffener member is connected to the proximal hub. The stiffener member extends through a portion of the inflation lumen. An occlusion balloon has a proximal balloon end and a distal balloon end. A distal catheter member is positioned substantially on the longitudinal axis and is connected to the distal end of the stiffener member. An atraumatic tip is positioned on a distal end of the distal catheter member. The atraumatic tip has a substantially circular profile in a relaxed configuration. A pressure sensor is connected to the occlusion catheter system distally relative to the occlusion balloon and is connected to a processor by electrical wiring. |
| FILED | Monday, April 11, 2022 |
| APPL NO | 17/717624 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/12036 (20130101) A61B 2017/00017 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 25/007 (20130101) A61M 25/008 (20130101) A61M 25/0068 (20130101) Original (OR) Class A61M 25/0074 (20130101) A61M 25/104 (20130101) A61M 25/1002 (20130101) A61M 25/1006 (20130101) A61M 25/10182 (20131105) A61M 2025/0002 (20130101) A61M 2025/1052 (20130101) A61M 2025/1086 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230001378 | Hoffman, Jr. et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher M. Hoffman, Jr. (Odenton, Maryland); Zhiyong Xia (Rockville, Maryland); James K. Johnson (Silver Spring, Maryland) |
| ABSTRACT | Contaminate-sequestering coatings including a network of hydrolyzed silane compounds including a plurality of thiol functional groups, a plurality of fluorinated functionalities, or both are provided. The contaminate-sequestering coatings may sequester one or more per- and polyfluoroalkyl substances (PFAS), heavy metals, biological species or any combination thereof. Methods of functionalizing a substrate surface with contaminate-sequestering functionalities that sequester one or more PFAS, heavy metals, or both are also provided. Methods of removing contaminants from contaminate-containing liquids, and devices including the contaminate-sequestering coatings are also provided. |
| FILED | Monday, August 22, 2022 |
| APPL NO | 17/892186 |
| CURRENT CPC | Separation B01D 39/086 (20130101) B01D 2239/0478 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/22 (20130101) Original (OR) Class B01J 20/3208 (20130101) B01J 20/3221 (20130101) B01J 20/3246 (20130101) B01J 20/28038 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/288 (20130101) C02F 2101/36 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230001385 | Christopher et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of The University Of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Philip Christopher (Santa Barbara, California); Ji Qi (Santa Barbara, California) |
| ABSTRACT | Catalysts containing a support and a metal oxide, and reactors and methods of using the catalysts in a carbonylation reaction, such as alcohol carbonylation and ester carbonylation, are described herein. The support is typically chemically inert and has a high surface area. The metal oxide typically contains a transition metal or a mixture of metals, such as rhenium, aluminum, tungsten, molybdenum, or a combination thereof. Typically, the metal oxide is mainly atomically dispersed on the surface of the support, as indicated by STEM. For example, at least 10% of the metal oxide is atomically dispersed on the surface of the support. The method includes (i) exposing a mixture of one or more alcohols or one or more esters and carbon monoxide to the catalyst. Typically, the one or more alcohols or one or more esters and carbon monoxide are in a gas phase. |
| FILED | Monday, November 16, 2020 |
| APPL NO | 17/776933 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/002 (20130101) B01J 23/36 (20130101) Original (OR) Class B01J 23/40 (20130101) B01J 35/1023 (20130101) B01J 35/1057 (20130101) B01J 2523/74 (20130101) Acyclic or Carbocyclic Compounds C07C 51/12 (20130101) C07C 2523/36 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230001400 | Goodson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Trustees of Southern Illinois University (Carbondale, Illinois); Vanderbilt University (Nashville, Tennessee); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | Board of Trustees of Southern Illinois University (Carbondale, Illinois); Vanderbilt University (Nashville, Tennessee); The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Boyd M. Goodson (Carbondale, Illinois); Eduard Y. Chekmenev (Troy, Michigan); Igor V. Koptyug (Novosibirsk, Russian Federation); Kirill V. Kovtunov (Novosibirsk, Russian Federation); Roman V. Shchepin (Nashville, Tennessee); Bryce E. Kidd (Carbondale, Illinois); Jonathan Gesiorski (Hickory Hills, Illinois); Max E. Gemeinhardt (Carbondale, Illinois); Danila A. Barskiy (Berkeley, California) |
| ABSTRACT | The present disclosure provides a method that embodies a simple and effective route to remove homogeneous catalysts from solutions wherein NMR/MRI signal amplification by reversible exchange (SABRE) or parahydrogen-induced polarization (PHIP) is performed. A method for recovering a homogeneous SABRE/PHIP catalyst for reuse is also described. |
| FILED | Monday, February 17, 2020 |
| APPL NO | 16/792637 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/1616 (20130101) B01J 31/2273 (20130101) B01J 31/2295 (20130101) B01J 31/4038 (20130101) Original (OR) Class B01J 38/02 (20130101) B01J 38/68 (20130101) B01J 2531/827 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002026 | Limpaecher et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Erik Limpaecher (Concord, Massachusetts); Eric Morgan (Bolton, Massachusetts) |
| ABSTRACT | Systems and methods related to deployable hydrogen reactors are described. In some embodiments, a system (e.g., a balloon system) may include a reaction chamber immersed in a body of water. By permitting a flow of water from the body of water into the reaction chamber, a reaction between a reactant and the water may be carried out to produce one or more lifting gases (e.g., hydrogen gas), which can be employed to subsequently inflate and launch the system in an automated fashion. |
| FILED | Friday, April 15, 2022 |
| APPL NO | 17/722228 |
| CURRENT CPC | Lighter-than Air Aircraft B64B 1/62 (20130101) Original (OR) Class Non-metallic Elements; Compounds Thereof; C01B 3/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002233 | Huang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jiaxing Huang (Wilmette, Illinois); Luke Clyde Oak Prestowitz (Evanston, Illinois) |
| ABSTRACT | Provided are methods for synthesizing a graphene gel. In embodiments, such a method comprises flowing a graphene oxide composition comprising graphene oxide and a solvent, the solvent having a boiling point higher than pure water, through a reaction chamber under conditions to deoxygenate the graphene oxide and induce gelation to form a graphene gel suspended in the solvent and flowing through the reaction chamber. |
| FILED | Wednesday, June 22, 2022 |
| APPL NO | 17/846293 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/194 (20170801) C01B 32/198 (20170801) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/72 (20130101) C01P 2004/03 (20130101) C01P 2006/40 (20130101) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002239 | Colon et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Brendan Cruz Colon (Cambridge, Massachusetts); Chong Liu (Cambridge, Massachusetts); Daniel G. Nocera (Cambridge, Massachusetts); Pamela Ann Silver (Cambridge, Massachusetts) |
| ABSTRACT | Systems and methods for producing ammonia are described. In one embodiment, hydrogen, carbon dioxide, and nitrogen are dissolved in a solution. A glutamine synthetase inhibitor and autotrophic diazotroph bacteria are also placed in the solution. |
| FILED | Thursday, August 04, 2022 |
| APPL NO | 17/880756 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/087 (20130101) B01J 2219/00761 (20130101) Ammonia; Cyanogen; Compounds Thereof C01C 1/04 (20130101) C01C 1/08 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 3/00 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/04 (20130101) C25B 11/061 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002491 | ZANG |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Albert Einstein College of Medicine (Bronx, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xingxing ZANG (New York, New York) |
| ABSTRACT | Provided are methods of treating an autoimmune disease in a subject, or of suppressing transplant rejection in a subject, or of treating a cancer in a subject, as well as compositions therefor. |
| FILED | Monday, January 24, 2022 |
| APPL NO | 17/648792 |
| CURRENT CPC | Peptides C07K 16/2827 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/24 (20130101) C07K 2319/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002546 | Boydston et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Jackson Boydston (Middleton, Wisconsin); Xuejin Yang (Madison, Wisconsin); Rachel Tritt (Middleton, Wisconsin); Margaret Tetzloff (Madison, Wisconsin) |
| ABSTRACT | A reactant composition for forming a polymer via metal-free ring-opening metathesis polymerization may comprise a stabilizer, a stabilizing reactant comprising a stabilizing moiety covalently bound to a reactant moiety, or both; wherein the stabilizer is a halogenated alcohol and the stabilizing moiety is derived from a halogenated alcohol. The reactant composition further comprises a strained cyclic unsaturated monomer; an initiator; a mediator; and optionally, one or more of a co-monomer, a crosslinker, and a chain transfer agent. |
| FILED | Tuesday, June 28, 2022 |
| APPL NO | 17/851312 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 61/08 (20130101) Original (OR) Class C08G 61/12 (20130101) C08G 2261/22 (20130101) C08G 2261/76 (20130101) C08G 2261/334 (20130101) C08G 2261/418 (20130101) C08G 2261/3324 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/05 (20130101) C08K 5/1545 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002709 | Breuer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Research Institute at Nationwide Children's Hospital (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Breuer (Columbus, Ohio); Cameron Best (Columbus, Ohio); Robert Strouse (Columbus, Ohio); James Reinhardt (Columbus, Ohio) |
| ABSTRACT | Closed disposable seeding systems with improved seeding chambers permitting uniform seeding of a scaffold or graft with patient's cells are provided. The seeding chambers with a variable width along the length of the chamber, or a minimal gap between the scaffold and chamber wall, provide an improvement of the prior seeding chambers of closed disposable seeding systems by providing faster and more efficient and uniform seeding of the grafts and scaffolds. Also described are scaffolds with biomechanical and structural properties permitting spontaneous reversal of stenosis and neotissue formation as the graft degrades yielding a scaffold-free neovessel. |
| FILED | Monday, November 16, 2020 |
| APPL NO | 17/776912 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) A61L 27/20 (20130101) A61L 27/34 (20130101) A61L 27/54 (20130101) A61L 27/56 (20130101) A61L 27/507 (20130101) A61L 27/3804 (20130101) A61L 2300/41 (20130101) A61L 2300/222 (20130101) A61L 2300/414 (20130101) A61L 2300/416 (20130101) A61L 2300/426 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 80/00 (20141201) Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) Original (OR) Class C12M 23/38 (20130101) C12M 25/14 (20130101) C12M 29/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002745 | Kim et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Yongjoo Kim (Cambridge, Massachusetts); David R. Liu (Cambridge, Massachusetts); Kevin Tianmeng Zhao (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein are compositions, systems, and methods for delivering an effector protein into a cell. The present disclosure, in some aspects, provide novel proteins delivering an effector protein into a cell. The novel proteins are supernegatively charged proteins derived from highly anionic proteins identified from the proteome (e.g., human proteome). The novel protein tags can be associated (e.g., covalently or nocovalently) with the protein to be delivered to facilitate delivery of the effector protein into a cell. |
| FILED | Thursday, January 23, 2020 |
| APPL NO | 17/425261 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5123 (20130101) A61K 38/00 (20130101) Peptides C07K 14/4702 (20130101) C07K 14/4728 (20130101) C07K 14/57581 (20130101) C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 9/78 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002758 | Kim et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Do Soon Kim (Evanston, Illinois); Michael Christopher Jewett (Evanston, Illinois) |
| ABSTRACT | The present disclosure relates to methods to evolve macromolecular machines and improved macromolecular machines identified and made by the methods. In some embodiments, the improved macromolecular machines include improved tethered ribosomes. Also disclosed are systems and methods for making and using the improved tethered ribosomes. |
| FILED | Wednesday, June 15, 2022 |
| APPL NO | 17/841618 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/70 (20130101) C12N 15/1041 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) C12P 21/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002809 | Samusik et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nikolay Samusik (Jacksonville, Oregon); Garry P. Nolan (Redwood City, California); Yury Goltsev (Stanford, California) |
| ABSTRACT | A method for analyzing planar sample is provided. In some cases the method comprises: (a) incubating the planar sample with a capture agent that is linked to an oligonucleotide, wherein the capture agent specifically binds to complementary sites in the planar sample; (b) reading a fluorescent signal caused by extension of a primer that is hybridized to the oligonucleotide, using fluorescence microscopy. Several implementations of the method, and multiplexed versions of the same, are also provided. |
| FILED | Tuesday, February 15, 2022 |
| APPL NO | 17/672552 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6804 (20130101) C12Q 1/6818 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002857 | Hornbuckle et al. |
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| FUNDED BY |
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| APPLICANT(S) | U.S. Army DEVCOM, Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Billy C. Hornbuckle (Bel Air, Maryland); Anthony J. Roberts (Chesapeake City, Maryland); Thomas L. Luckenbaugh (Spring Grove, Pennsylvania); Anit K. Giri (Abingdon, Maryland); Kristopher A. Darling (Havre de Grace, Maryland) |
| ABSTRACT | Alloys comprised of a refined microstructure, ultrafine or nano scaled, that when reacted with water or any liquid containing water will spontaneously and rapidly produce hydrogen at ambient or elevated temperature are described. These metals, termed here as aluminum based nanogalvanic alloys will have applications that include but are not limited to energy generation on demand. The alloys may be composed of primarily aluminum and other metals e.g., tin bismuth, indium, gallium, lead, etc. and/or carbon, and mixtures and alloys thereof. The alloys may be processed by ball milling for the purpose of synthesizing powder feed stocks, in which each powder particle will have the above-mentioned characteristics. These powders can be used in their inherent form or consolidated using commercially available techniques for the purpose of manufacturing useful functional components. |
| FILED | Wednesday, September 07, 2022 |
| APPL NO | 17/939473 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 9/04 (20130101) B22F 2009/043 (20130101) Non-metallic Elements; Compounds Thereof; C01B 3/08 (20130101) Alloys C22C 1/0416 (20130101) Original (OR) Class C22C 21/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002935 | Yuan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Naval Medical Research Center (Silver Spring, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tony T Yuan (Boerne, Texas); Kirstin Jones (Sugar Land, Texas); Cortes Williams, III (Sugar Land, None) |
| ABSTRACT | An electrospinning apparatus and method for producing three-dimensional electrospun constructs is disclosed. Further, electrospinning apparatus and method 3D electrospun collagen based mineralized nanofibrous scaffold for alveolar ridge preservation prior to dental implant therapy are disclosed. |
| FILED | Thursday, June 23, 2022 |
| APPL NO | 17/848288 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/24 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/0023 (20130101) D01D 5/0076 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230003177 | YANDEK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio); Government of Japan, as represented by the Commissioner of the Acquisition, Technology and Logistics (Tokyo, Japan); IHI Aerospace Co., Ltd. (Tokyo, Japan) |
| ASSIGNEE(S) | Government of the United States, represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio); Government of Japan, as represented by the Commissioner of the Acquisition, Technology and Logistics (Tokyo, Japan); IHI Aerospace Co., Ltd. (Tokyo, Japan) |
| INVENTOR(S) | Gregory R. YANDEK (Wright-Patterson AFB, Ohio); Takayuki EDANAGA (Tokyo, Japan); Seiki HASHINO (Tokyo, Japan); Hiroshi SATO (Tokyo, Japan); Masaaki SATAKE (Tokyo, Japan); Masanori SAKAINO (Tokyo, Japan) |
| ABSTRACT | The present invention relates to resin compositions, fiber reinforced polymeric structures and electromagnetic induction processes for making same. Such magnetic induction processes are pulsed processes that can be optionally coupled with cooling steps between pulses. The aforementioned fiber reinforced polymeric structures can take forms that include, but are not limited to, pipes; pressure vessels, including rocket motor cases and fire extinguishers; golf club shafts; tennis and badminton racquets; skis; snowboards; hockey sticks; fishing rods; bicycle frames; boat masts; oars; paddles; baseball bats; and softball bats. In addition, such fiber reinforced polymeric structures can be supplemented with other materials, such as a rocket propellant, to form articles, for example, a rocket motor. |
| FILED | Thursday, November 19, 2020 |
| APPL NO | 17/779954 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 70/32 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2079/085 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 73/12 (20130101) C08G 73/065 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/042 (20130101) C08J 5/243 (20210501) C08J 2363/00 (20130101) C08J 2379/00 (20130101) Jet-propulsion Plants F02K 9/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230003577 | Rentzepis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Peter M. Rentzepis (College Station, Texas); Dinesh Dhankhar (Byran, Texas); Anushka Nagpal (Hillsboro, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter M. Rentzepis (College Station, Texas); Dinesh Dhankhar (Byran, Texas); Anushka Nagpal (Hillsboro, Oregon) |
| ABSTRACT | A small, handheld Raman spectrometer device can be built from a laser, lenses, and a diffraction grating configured in a right-angle Raman spectroscopy geometry, and used in conjunction with a cell-phone camera to record the Raman spectra. The cell-phone-based Raman spectrometer system is suited to performing in-situ measurements of chemical and biological molecules. |
| FILED | Friday, July 01, 2022 |
| APPL NO | 17/810477 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/0202 (20130101) G01J 3/0208 (20130101) G01J 3/0272 (20130101) Original (OR) Class G01J 3/0291 (20130101) G01J 3/4412 (20130101) G01J 2003/2836 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230003657 | Jiang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peng Jiang (Gainesville, Florida); Zhuxiao GU (Gainesville, Florida); Sin-Yen LEO (Gainesville, Florida) |
| ABSTRACT | Described are chromogenic sensors, methods of use, and kits including sensors. The sensors can have a polymer structure with a waveform cross-section in a programmed state. Upon exposure to a first liquid, the polymer structure in the programmed state changes to polymer structure in an activated state. Methods for measuring the presence of a liquid using the sensor are described, as are kits including the sensors. |
| FILED | Thursday, September 01, 2022 |
| APPL NO | 17/901286 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/78 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230003684 | Fury et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Brewer Science, Inc. (Rolla, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan J. Fury (Springfield, Missouri); Xi Cao (Tracy, California); Christopher Landorf (Springfield, Missouri); Zun Chen (Springfield, Missouri); Alec Neeson (Springfield, Missouri); Weston Bowen (Springfield, Missouri); Austin Peters (Springfield, Missouri) |
| ABSTRACT | A carbon nanotube (CNT) ion-selective field effect transistor (IS-FET) integrated device is used to detect nitrate ion in water. The device is operated as an IS-FET sensor, holding the measured potential between the drain electrode and an external reference electrode constant with a potentiometric circuit. Transduction occurs by changes in the effective CNT film gate potential with changes in the phase boundary potential of an ion-selective membrane (ISM) film. Moreover, the nitrate ISM film makes the device highly selective towards nitrate sensing. This printable IS-FET nitrate sensor enables real-time and high-resolution measurements and recording of nitrate ion in water at low cost. |
| FILED | Friday, July 01, 2022 |
| APPL NO | 17/856932 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/02 (20130101) G01N 27/4146 (20130101) G01N 27/4148 (20130101) Original (OR) Class G01N 33/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230003744 | Hu |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey); Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William T. Hu (New Brunswick, New Jersey) |
| ABSTRACT | Embodiments of the disclosure are directed to biomarkers, or a panel of biomarkers, that determine progression of Alzheimer's disease, and methods of use thereof. |
| FILED | Thursday, June 16, 2022 |
| APPL NO | 17/842433 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) Original (OR) Class G01N 2800/56 (20130101) G01N 2800/2821 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230004049 | Spillmann et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher M. Spillmann (Washington, District of Columbia); Colin P. McGinty (Washington, District of Columbia); Jakub Kolacz (Washington, District of Columbia); Henry G. Gotjen (Washington, District of Columbia) |
| ABSTRACT | The azo dye brilliant yellow operates to align liquid crystal molecules in three dimensions, for example to establish a desired in-plane alignment and pre-tilt angle. This technique provides a wide range selectable and re-writable pretilt angles from 0° to nearly 90°. |
| FILED | Thursday, June 30, 2022 |
| APPL NO | 17/854055 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/133761 (20210101) G02F 1/133788 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230004524 | Brewer |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tony Brewer (Plano, Texas) |
| ABSTRACT | Disclosed in some examples, are methods, systems, programmable atomic units, and machine-readable mediums that provide an exception as a response to the calling processor. That is, the programmable atomic unit will send a response to the calling processor. The calling processor will recognize that the exception has been raised and will handle the exception. Because the calling processor knows which process triggered the exception, the calling processor (e.g., the Operating System) can take appropriate action, such as terminating the calling process. The calling processor may be a same processor as that executing the programmable atomic transaction, or a different processor (e.g., on a different chiplet). |
| FILED | Thursday, September 01, 2022 |
| APPL NO | 17/901480 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/4406 (20130101) G06F 15/82 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230005088 | PHIPPS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | CHRISTOPHER PHIPPS (Chico, California); CATHERINE DESESA (Wilmette, Illinois); Kaitlyn Leedy (Frostburg, Maryland); Matthew Bellio (Chicago, Illinois); Charles E. Beller (Baltimore, Maryland) |
| ABSTRACT | In an approach for identifying troubled contracts using a health score, a processor receives a contract. A processor identifies a list of requirements of the contract using a first Natural Language Processing technique. A processor trains a model to recognize the list of requirements of the contract. A processor receives at least one deliverable document associated with the contract. A processor applies a plurality of health metrics to the at least one deliverable document associated with the contract to identify evidence of completion of each requirement of the list of requirements of the contract. A processor outputs the health score for each requirement of the list of requirements of the contract. |
| FILED | Wednesday, June 23, 2021 |
| APPL NO | 17/355356 |
| CURRENT CPC | Electric Digital Data Processing G06F 40/247 (20200101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00442 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 50/18 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230005134 | MATTREY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | The Board of Regents of The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Robert F. MATTREY (Dallas, Texas); Caroline DE GRACIA LUX (Dallas, Texas); Jacques LUX (Dallas, Texas); Zhenghong GAO (Dallas, Texas); Carlos J. BRAMBILA (Dallas, Texas) |
| ABSTRACT | The disclosure describes imaging and therapy techniques comprising nanodroplets. More particularly, aspects of the disclosure relate to the use of nanodroplets to modify nanobubbles or microbubbles to provide improved imaging and/or therapeutic techniques and compositions. |
| FILED | Friday, May 13, 2022 |
| APPL NO | 17/744423 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 7/02 (20130101) A61N 2007/0039 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 7/62 (20170101) G06T 2207/20104 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230005145 | Madabhushi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anant Madabhushi (Shaker Heights, Ohio); Cristian Barrera (Bogota, Colombia); German Corredor (Bogota, Colombia); Eduardo Romero (Bogota, Colombia) |
| ABSTRACT | The present disclosure relates to an apparatus including one or more processors configured to receive a digitized image of a region of tissue demonstrating a disease, and containing cellular structures represented in the digitized image, each of the cellular structures being associated with a cell category of a plurality of cell categories; select a cellular structure of the cellular structures based on the cell category for the cellular structure; for the cellular structure selected, compute a set of contextual features; assign, based on the set of contextual features, the cellular structure to at least one cluster of a plurality of clusters; compute cluster features, the cluster features describing characteristics of the at least one cluster of the plurality of clusters; and generate a prediction that describes a pathologic or phenotypic state of the disease based, at least in part, on the cluster features and/or the set of contextual features. |
| FILED | Thursday, September 08, 2022 |
| APPL NO | 17/940243 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6228 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 2207/10056 (20130101) G06T 2207/20081 (20130101) G06T 2207/30024 (20130101) G06T 2207/30061 (20130101) G06T 2207/30096 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 40/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230005694 | Rameau et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Physical Sciences, Inc. (Andover, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan D. Rameau (Somerville, Massachusetts); Nicholas R. Craig (Somerville, Massachusetts) |
| ABSTRACT | A triple-point cathode coating and method wherein electrically conductive NEA diamond particles cast or mixed with the adhesive medium and electrically insulative NEA diamond particles are cast or mixed with the adhesive medium to form a plurality of exposed junctions between electrically conductive diamond particles and electrically insulative diamond particles to reduce any electrical charges on a structure coated with the coating. |
| FILED | Tuesday, September 13, 2022 |
| APPL NO | 17/943446 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/226 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/24 (20130101) C09D 163/00 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 1/3044 (20130101) Original (OR) Class H01J 3/022 (20130101) H01J 9/025 (20130101) H01J 2201/30411 (20130101) H01J 2201/30457 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 427/103 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230006331 | RAO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Aerospace Corporation (El Segubdo, California) |
| ASSIGNEE(S) | The Aerospace Corporation (El Segundo, California) |
| INVENTOR(S) | Vikram M. RAO (Torrance, California); Vahagn PETROSYAN (Northridge, California) |
| ABSTRACT | Embedded antennas in integrated circuits, and methods of making and using the same, are provided herein. An integrated circuit within a semiconductor die may include a control circuit; an antenna configured to wirelessly receive a control signal at a predefined frequency; and an interconnect configured to provide the received control signal from the antenna to the control circuit. The control circuit may be configured to control a function of the integrated circuit responsive to the received control signal. |
| FILED | Friday, July 02, 2021 |
| APPL NO | 17/366657 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/66 (20130101) H01L 2223/6677 (20130101) Antennas, i.e Radio Aerials H01Q 1/2283 (20130101) Original (OR) Class Pulse Technique H03K 19/17744 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230006674 | BHUNIA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Universty of Florida Research Foundation, Incorporated (Gainsville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Swarup BHUNIA (Gainesville, Florida); Aritra DASGUPTA (Gainesville, Florida); Pravin GAIKWAD (Gainesville, Florida); Md Moshiur RAHMAN (Gainesville, Florida); Aritra BHATTACHARYAY (Gainesville, Florida) |
| ABSTRACT | A method and system are directed to protecting hardware IP, particularly of ASIC designs. Programmability is introduced into an ASIC design to increase the difficulty of formulating ASIC designs as Boolean Satisfiability (SAT) problems. Fine-grain redaction of security-critical information from a design is employed by removing high-entropy logic blocks and subsequently inserting programmable components in place of the redacted portion to hide the actual design intent. |
| FILED | Wednesday, June 22, 2022 |
| APPL NO | 17/808179 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/4498 (20180201) G06F 9/30134 (20130101) Pulse Technique H03K 19/21 (20130101) H03K 19/17728 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20230000377 | WU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland); NORTH CAROLINA STATE UNIVERSITY (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Min WU (Clarksville, Maryland); Xin TIAN (College Park, Maryland); Joshua Regi MATHEW (Durham, North Carolina); Chau-Wai WONG (Apex, North Carolina) |
| ABSTRACT | Systems, methods, apparatuses, and computer program products for contactless image-based blood oxygen estimation. A method may include receiving an image or video of a part of a subject captured by a camera of a computing device. The method may also include extracting a region of interest of the part of the subject from the image or video. The method may further include performing feature extraction of the region of interest. In addition, the method may include estimating a blood oxygen saturation level of the subject based on a spatial and temporal data analysis of more than two color channels. Feature extraction and estimation of the blood oxygen saturation level may include implementing a combination of spatial averaging, color channel mixing, and temporal trend analysis. |
| FILED | Friday, June 24, 2022 |
| APPL NO | 17/849414 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/02416 (20130101) Original (OR) Class Image or Video Recognition or Understanding G06V 10/25 (20220101) G06V 10/56 (20220101) G06V 10/62 (20220101) G06V 10/82 (20220101) G06V 40/11 (20220101) G06V 40/15 (20220101) G06V 40/117 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230000426 | Makin, III et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF WESTERN MICHIGAN UNIVERSITY (Kalamazoo, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Allen Makin, III (Kalamazoo, Michigan); Steven Michael Durbin (Kalamazoo, Michigan) |
| ABSTRACT | A method of distinguishing benign and malignant skin conditions includes extracting a numerical value corresponding to an order parameter from an image of skin having a pigmented region. The numerical value of the order parameter may be utilized to assess the likelihood that a skin lesion is benign or malignant. The precise value may also be utilized to assess severity, which may include detecting changes in a skin lesion over time. |
| FILED | Tuesday, June 14, 2022 |
| APPL NO | 17/839980 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0059 (20130101) A61B 5/444 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/30088 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230000445 | Reich |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alton Reich (Huntsville, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alton Reich (Huntsville, Alabama) |
| ABSTRACT | The invention comprises a method for estimating state of a cardiovascular system, comprising the steps of: providing a cardiac analyzer, comprising: a blood pressure sensor, the blood pressure sensor generating a time-varying pressure state waveform output from a portion of a person; a system processor connected to the blood pressure sensor; and a dynamic state-space model of a cardiovascular system, the system processor receiving cardiovascular input data, from the blood pressure sensor, related to a transient pressure state of the cardiovascular system, where at least one probabilistic model, of the dynamic state-space model, operating on the time-varying pressure state waveform output generates a probability distribution function to a non-pressure state of the cardiovascular system. The probability distribution function is iteratively updated using synchronized updated time-varying pressure state waveform output from the blood pressure sensor and a non-pressure state output related to a cardiovascular system parameter is generated. |
| FILED | Friday, June 17, 2022 |
| APPL NO | 17/843697 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/022 (20130101) A61B 5/0205 (20130101) A61B 5/0245 (20130101) A61B 5/725 (20130101) A61B 5/744 (20130101) A61B 5/7217 (20130101) A61B 5/7246 (20130101) Original (OR) Class A61B 5/14551 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230000650 | GODZICH ELAKKAD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Chanya GODZICH ELAKKAD (Baltimore, Maryland); Teja MARUVADA (Baltimore, Maryland); Joseph A. PIA (Baltimore, Maryland); Shravya SRIGIRI (Minneapolis, Minnesota); Kendall COVINGTON (Baltimore, Maryland); Edward James WRIGHT (Severna Park, Maryland) |
| ABSTRACT | An embodiment in accordance with the present invention provides a device and method for the treatment of urethral stricture. The present invention places and holds a graft at an incised urethral stricture site for 5-21 days, while the graft adherences to the incised urethral stricture site. A device of the present invention includes a delivery component, a graft carrier component, and a removal component. In some embodiments, the delivery and removal components may be combined into the same device. The delivery component, the graft carrier component, and the removal component are all configured to enter and exit the urethra without trauma. A method according to an embodiment of the present invention includes harvesting a graft, loading the graft onto the graft carrier component, introducing the delivery device into the urethra with the graft carrier component and graft loaded, and delivering of the graft to the incised urethral stricture site. |
| FILED | Thursday, September 01, 2022 |
| APPL NO | 17/929076 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/04 (20130101) A61F 2/95 (20130101) Original (OR) Class A61F 2002/047 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230000772 | Davis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF UTAH RESEARCH FOUNDATION (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brett Davis (Salt Lake City, Utah); Andrew M. Simpson (Salt Lake City, Utah); Jayant P. Agarwal (Salt Lake City, Utah); Jill E. Shea (Salt Lake City, Utah); Himanshu Jayant Sant (Salt Lake City, Utah); Bruce K. Gale (Salt Lake City, Utah) |
| ABSTRACT | An opioid independent surgical anesthetic composition includes an injectable dosage form of a hydrogel having a plurality of solid lipid matrix particles entrapped therein. The solid lipid matrix particles include a lipophilic local anesthetic drug and a lipid glyceride (e.g., saturated triglyceride or lipid blend of various lipid glycerides). Methods for creating a long-acting local anesthetic product can include creating a bulk solid of a lipid matrix product by heating a lipid solvent above its melting point, dissolving a lipophilic local anesthetic drug therein, reducing a temperature of the resultant drug-lipid solution to below the melting point of the lipid solvent, and heat annealing the lipid matrix to remove or reduce presence of any unstable polymorphs in the lipid matrix. The methods can further include crushing the bulk solid of the lipid matrix product to form solid lipid matrix particles and entrapping the solid lipid matrix particles within a hydrogel. |
| FILED | Tuesday, March 01, 2022 |
| APPL NO | 17/683687 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/127 (20130101) Original (OR) Class A61K 9/1277 (20130101) A61K 31/445 (20130101) A61K 47/36 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230001011 | Xu |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qiaobing Xu (Lexington, Massachusetts) |
| ABSTRACT | A nanocomplex, 50 to 1000 nm in size, containing a lipid-like nanoparticle formed of a cationic lipid-based compound and a modified protein formed of a protein and an anionic polymer that includes a plurality of polar groups, the lipid-like nanoparticle and the modified protein being non-covalently bonded to each other. Also disclosed are a method of preparing the above-described nanocomplex and use thereof for treating a medical condition. Further disclosed is a pharmaceutical composition containing a nanocomplex. |
| FILED | Friday, January 21, 2022 |
| APPL NO | 17/581482 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/45 (20130101) A61K 45/06 (20130101) A61K 47/61 (20170801) A61K 47/543 (20170801) A61K 47/6907 (20170801) A61K 47/6939 (20170801) Original (OR) Class Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230001039 | LIU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Metalmark Innovations PBC (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Metalmark Innovations PBC (Cambridge, Massachusetts) |
| INVENTOR(S) | Sissi LIU (Arlington, Massachusetts); Elijah SHIRMAN (Winchester, Massachusetts); Tanya SHIRMAN (Winchester, Massachusetts) |
| ABSTRACT | An air purification system includes a conduit extending between an inlet and an outlet, each in fluid communication with an enclosed environment. Ambient air from the enclosed environment enters the conduit via the inlet and treated air exits the conduit and enters the enclosed environment via the outlet. The system further includes a fibrous filter disposed within the conduit and configured to treat the ambient air thereby generating the treated air, and a renewal unit disposed within the conduit and configured to renew the fibrous filter. |
| FILED | Wednesday, March 30, 2022 |
| APPL NO | 17/709069 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 9/16 (20130101) Original (OR) Class A61L 9/205 (20130101) A61L 2209/12 (20130101) A61L 2209/14 (20130101) A61L 2209/21 (20130101) A61L 2209/22 (20130101) A61L 2209/111 (20130101) Separation B01D 39/1607 (20130101) B01D 39/2041 (20130101) B01D 46/0028 (20130101) B01D 46/0036 (20130101) B01D 46/785 (20220101) B01D 2239/0442 (20130101) B01D 2239/0492 (20130101) B01D 2273/30 (20130101) B01D 2279/50 (20130101) B01D 2279/65 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230001321 | Yagoobi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Worcester Polytechnic Institute (Worcester, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jamal S. Yagoobi (Hopkinton, Massachusetts); Mengqiao Yang (Worcester, Massachusetts); Mehrnoosh F. Dardashti (Worcester, Massachusetts) |
| ABSTRACT | An atomizing spray dryer employs one or more stages defined by ultrasonic transducers in close proximity to a liquid feed opening forming a path of an atomization flow for producing uniform droplets from a close tolerance with the transducer. The atomization flow exits a gap between the transducer and an outer edge of the opening, such that the passed liquid is responsive to an oscillation of the transducer for forming the droplets. A conical or other suitably shaped transducer engages a substantially round liquid feed opening. Subsequent stages may include a circular, ring, or other suitable shape aligned to receive the atomization flow from a circumference of the conical base, or may also take any suitable shape, preferably to receive droplets directed by the first stage. |
| FILED | Wednesday, June 29, 2022 |
| APPL NO | 17/853152 |
| CURRENT CPC | Separation B01D 1/18 (20130101) Original (OR) Class B01D 1/20 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 2/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230001400 | Goodson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Trustees of Southern Illinois University (Carbondale, Illinois); Vanderbilt University (Nashville, Tennessee); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | Board of Trustees of Southern Illinois University (Carbondale, Illinois); Vanderbilt University (Nashville, Tennessee); The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Boyd M. Goodson (Carbondale, Illinois); Eduard Y. Chekmenev (Troy, Michigan); Igor V. Koptyug (Novosibirsk, Russian Federation); Kirill V. Kovtunov (Novosibirsk, Russian Federation); Roman V. Shchepin (Nashville, Tennessee); Bryce E. Kidd (Carbondale, Illinois); Jonathan Gesiorski (Hickory Hills, Illinois); Max E. Gemeinhardt (Carbondale, Illinois); Danila A. Barskiy (Berkeley, California) |
| ABSTRACT | The present disclosure provides a method that embodies a simple and effective route to remove homogeneous catalysts from solutions wherein NMR/MRI signal amplification by reversible exchange (SABRE) or parahydrogen-induced polarization (PHIP) is performed. A method for recovering a homogeneous SABRE/PHIP catalyst for reuse is also described. |
| FILED | Monday, February 17, 2020 |
| APPL NO | 16/792637 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/1616 (20130101) B01J 31/2273 (20130101) B01J 31/2295 (20130101) B01J 31/4038 (20130101) Original (OR) Class B01J 38/02 (20130101) B01J 38/68 (20130101) B01J 2531/827 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002546 | Boydston et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Jackson Boydston (Middleton, Wisconsin); Xuejin Yang (Madison, Wisconsin); Rachel Tritt (Middleton, Wisconsin); Margaret Tetzloff (Madison, Wisconsin) |
| ABSTRACT | A reactant composition for forming a polymer via metal-free ring-opening metathesis polymerization may comprise a stabilizer, a stabilizing reactant comprising a stabilizing moiety covalently bound to a reactant moiety, or both; wherein the stabilizer is a halogenated alcohol and the stabilizing moiety is derived from a halogenated alcohol. The reactant composition further comprises a strained cyclic unsaturated monomer; an initiator; a mediator; and optionally, one or more of a co-monomer, a crosslinker, and a chain transfer agent. |
| FILED | Tuesday, June 28, 2022 |
| APPL NO | 17/851312 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 61/08 (20130101) Original (OR) Class C08G 61/12 (20130101) C08G 2261/22 (20130101) C08G 2261/76 (20130101) C08G 2261/334 (20130101) C08G 2261/418 (20130101) C08G 2261/3324 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/05 (20130101) C08K 5/1545 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002727 | Fan et al. |
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| FUNDED BY |
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| APPLICANT(S) | Allegheny Singer Research Institute (Pittsburgh, Pennsylvania); University of Pittsburgh - of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yong Fan (Pittsburgh, Pennsylvania); Ann Zeleniak (Pittsburgh, Pennsylvania); Massimo Trucco (Pittsburgh, Pennsylvania); Ipsita Banerjee (Pittsburgh, Pennsylvania) |
| ABSTRACT | This document relates to bioengineering and involves bioengineered thymus organoids and related humanized animal models. The thymus organoids and animal models have various commercial and clinical uses, including generating humanized antibodies, making antigen-specific human T cells, inducing transplantation tolerance, rejuvenating thymus functions, and modeling human diseases. |
| FILED | Wednesday, November 25, 2020 |
| APPL NO | 17/756398 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0278 (20130101) A01K 2207/12 (20130101) A01K 2217/15 (20130101) A01K 2227/105 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 35/26 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0012 (20130101) C12N 5/065 (20130101) Original (OR) Class C12N 5/0647 (20130101) C12N 5/0697 (20130101) C12N 2501/15 (20130101) C12N 2501/16 (20130101) C12N 2501/125 (20130101) C12N 2501/145 (20130101) C12N 2501/155 (20130101) C12N 2506/45 (20130101) C12N 2513/00 (20130101) C12N 2533/74 (20130101) C12N 2533/90 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002728 | Palecek et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sean Palecek (Verona, Wisconsin); Gyuhyung Jin (Madison, Wisconsin) |
| ABSTRACT | This disclosure relates generally to the differentiation of human pluripotent stem cells, and more particularly to a method of spatially adsorbing morphogens to differentiate human pluripotent stem cells. |
| FILED | Friday, July 01, 2022 |
| APPL NO | 17/856653 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0606 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/4833 (20130101) G01N 33/5044 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002758 | Kim et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Do Soon Kim (Evanston, Illinois); Michael Christopher Jewett (Evanston, Illinois) |
| ABSTRACT | The present disclosure relates to methods to evolve macromolecular machines and improved macromolecular machines identified and made by the methods. In some embodiments, the improved macromolecular machines include improved tethered ribosomes. Also disclosed are systems and methods for making and using the improved tethered ribosomes. |
| FILED | Wednesday, June 15, 2022 |
| APPL NO | 17/841618 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/70 (20130101) C12N 15/1041 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) C12P 21/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002825 | Guo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Feng Guo (Los Angeles, California); Grant Shoffner (Los Angeles, California) |
| ABSTRACT | The invention provides methods and materials that can be used to determine three dimensional structures of RNA hairpin loops and their complexes with inhibitors easily and quickly. The scaffold RNA, YdaO-type c-di-AMP riboswitch from Thermoanaerobacterpseudethanolicus, readily forms crystals with a large cavity over 60 in diameter. A hairpin of interest can be engineered into the P2 stem of this RNA so that the hairpin is accommodated in the cavity. The fusion RNA is then crystallized, and structures can be determined using X-ray or electron crystallography. Embodiments of the invention can be used to identify compounds that bind hairpin loops in order to, for example, effect therapeutic and other biological activities. |
| FILED | Thursday, November 19, 2020 |
| APPL NO | 17/776943 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6876 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230003188 | Vermillion et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chris Vermillion (Raleigh, North Carolina); James Christopher Reed (Raleigh, North Carolina); Joshua L. Daniels (Raleigh, North Carolina); Mitchell Cobb (Raleigh, North Carolina); Ayaz Siddiqui (Raleigh, North Carolina) |
| ABSTRACT | Various examples are provided related to kite energy generation. In one example, a method for kite-based energy generation includes deploying a kite in a flow of fluid; controlling movement of the kite along a continuous pattern across the flow, where the kite applies tension greater than a threshold during at least a first portion of the pattern and applies tension less than the threshold during at least a second portion of the pattern; and generating power during the first portion of the continuous pattern. In another example, a system includes a kite including control surfaces that control movement of the kite along a continuous pattern across the flow of fluid; a winch connected to the kite by a tether, and a generator of the winch that can generate power during a portion of the pattern; and a spool controller that can control spooling of the tether during the pattern. |
| FILED | Tuesday, June 28, 2022 |
| APPL NO | 17/851951 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 31/06 (20130101) Wind Motors F03D 5/06 (20130101) Original (OR) Class F03D 9/32 (20160501) F03D 13/20 (20160501) Indexing Scheme Relating to Wind, Spring, Weight, Inertia or Like Motors, to Machines or Engines for Liquids Covered by Subclasses F03B, F03D and F03G F05B 2240/921 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230003632 | Berg et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Kansas State University Research Foundation (Manhattan, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew J. Berg (Manhattan, Kansas); Jesse Laning (Manhattan, Kansas) |
| ABSTRACT | Described herein are apparatus and methods for orthographic imaging of particles. Particularly, a method to obtain contact-free images of aerosol particles with digital holography from three orthogonal directions is described and demonstrated. Diode lasers of different wavelengths simultaneously illuminate free flowing particles to form holograms on three sensors. Images of the particles are reconstructed from the holograms and used to infer the three-dimensional structure of single spherical particles or clusters of sphere-like particles. The apparatus employs inexpensive components and requires no lenses to achieve the imaging, which gives it a large sensing volume and simple design. |
| FILED | Friday, September 18, 2020 |
| APPL NO | 17/642441 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/147 (20130101) Original (OR) Class G01N 15/1436 (20130101) G01N 2015/0046 (20130101) G01N 2015/1445 (20130101) G01N 2015/1497 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230003657 | Jiang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peng Jiang (Gainesville, Florida); Zhuxiao GU (Gainesville, Florida); Sin-Yen LEO (Gainesville, Florida) |
| ABSTRACT | Described are chromogenic sensors, methods of use, and kits including sensors. The sensors can have a polymer structure with a waveform cross-section in a programmed state. Upon exposure to a first liquid, the polymer structure in the programmed state changes to polymer structure in an activated state. Methods for measuring the presence of a liquid using the sensor are described, as are kits including the sensors. |
| FILED | Thursday, September 01, 2022 |
| APPL NO | 17/901286 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/78 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230003669 | Tajin et al. |
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| FUNDED BY |
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| APPLICANT(S) | Drexel University (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | Drexel University (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Md Abu Saleh Tajin (Philadelphia, Pennsylvania); Kapil R. Dandekar (Philadelphia, Pennsylvania) |
| ABSTRACT | A passive UHF (Ultra High Frequency, 902-928 MHz) RFID-based fabric (such as a diaper) moisture sensor is low-cost, user-friendly, reusable, washable, environment-friendly and comes with an extended on-body read range of 3.6 meters with baby diapers and 4.4 meters with adult diapers. The external reader unit is connected to the internet or a local network, and may automatically notify the parents or caregivers as soon as the presence of moisture is detected. |
| FILED | Thursday, September 01, 2022 |
| APPL NO | 17/929059 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 22/04 (20130101) Original (OR) Class Antennas, i.e Radio Aerials H01Q 1/273 (20130101) H01Q 1/2208 (20130101) H01Q 9/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230004081 | Meyers et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Inpria Corporation (Corvallis, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen T. Meyers (Corvallis, Oregon); Douglas A. Keszler (Corvallis, Oregon); Kai Jiang (Corvallis, Oregon); Jeremy T. Anderson (Corvallis, Oregon); Andrew Grenville (Corvallis, Oregon) |
| ABSTRACT | Organometallic solutions have been found to provide high resolution radiation based patterning using thin coatings. The patterning can involve irradiation of the coated surface with a selected pattern and developing the pattern with a developing agent to form the developed image. The patternable coatings may be susceptible to positive-tone patterning or negative-tone patterning based on the use of an organic developing agent or an aqueous acid or base developing agent. The radiation sensitive coatings can comprise a metal oxo/hydroxo network with organic ligands. A precursor solution can comprise an organic liquid and metal polynuclear oxo-hydroxo cations with organic ligands having metal carbon bonds and/or metal carboxylate bonds. |
| FILED | Tuesday, September 06, 2022 |
| APPL NO | 17/903369 |
| CURRENT CPC | Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/09 (20130101) G03F 7/20 (20130101) G03F 7/30 (20130101) G03F 7/32 (20130101) G03F 7/0042 (20130101) Original (OR) Class G03F 7/0043 (20130101) G03F 7/322 (20130101) G03F 7/325 (20130101) G03F 7/2002 (20130101) G03F 7/2037 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230004082 | Meyers et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Inpria Corporation (Corvallis, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen T. Meyers (Corvallis, Oregon); Douglas A. Keszler (Corvallis, Oregon); Kai Jiang (Corvallis, Oregon); Jeremy T. Anderson (Corvallis, Oregon); Andrew Grenville (Corvallis, Oregon) |
| ABSTRACT | Organometallic solutions have been found to provide high resolution radiation based patterning using thin coatings. The patterning can involve irradiation of the coated surface with a selected pattern and developing the pattern with a developing agent to form the developed image. The patternable coatings may be susceptible to positive-tone patterning or negative-tone patterning based on the use of an organic developing agent or an aqueous acid or base developing agent. The radiation sensitive coatings can comprise a metal oxo/hydroxo network with organic ligands. A precursor solution can comprise an organic liquid and metal polynuclear oxo-hydroxo cations with organic ligands having metal carbon bonds and/or metal carboxylate bonds. |
| FILED | Tuesday, September 06, 2022 |
| APPL NO | 17/903605 |
| CURRENT CPC | Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/09 (20130101) G03F 7/20 (20130101) G03F 7/30 (20130101) G03F 7/32 (20130101) G03F 7/0042 (20130101) Original (OR) Class G03F 7/0043 (20130101) G03F 7/322 (20130101) G03F 7/325 (20130101) G03F 7/2002 (20130101) G03F 7/2037 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230004083 | Meyers et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Inpria Corporation (Corvallis, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen T. Meyers (Corvallis, Oregon); Douglas A. Keszler (Corvallis, Oregon); Kai Jiang (Corvallis, Oregon); Jeremy T. Anderson (Corvallis, Oregon); Andrew Grenville (Corvallis, Oregon) |
| ABSTRACT | Organometallic solutions have been found to provide high resolution radiation based patterning using thin coatings. The patterning can involve irradiation of the coated surface with a selected pattern and developing the pattern with a developing agent to form the developed image. The patternable coatings may be susceptible to positive-tone patterning or negative-tone patterning based on the use of an organic developing agent or an aqueous acid or base developing agent. The radiation sensitive coatings can comprise a metal oxo/hydroxo network with organic ligands. A precursor solution can comprise an organic liquid and metal polynuclear oxo-hydroxo cations with organic ligands having metal carbon bonds and/or metal carboxylate bonds. |
| FILED | Tuesday, September 06, 2022 |
| APPL NO | 17/903672 |
| CURRENT CPC | Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/09 (20130101) G03F 7/20 (20130101) G03F 7/30 (20130101) G03F 7/32 (20130101) G03F 7/0042 (20130101) Original (OR) Class G03F 7/0043 (20130101) G03F 7/322 (20130101) G03F 7/325 (20130101) G03F 7/2002 (20130101) G03F 7/2037 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230004367 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of the University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tongping Liu (San Antonio, Texas); Mohammad Mejbah ul Alam (San Antonio, Texas); Abdullah Al Muzahid (San Antonio, Texas) |
| ABSTRACT | The techniques described herein may provide techniques to detect, categorize, and diagnose synchronization issues that provide improved performance and issue resolution. For example, in an embodiment, a method may comprise detecting occurrence of synchronization performance problems in software code, when at least some detected synchronization performance problems occur when a contention rate for software locks is low, determining a cause of the synchronization performance problems, and modifying the software code to remedy the cause of the synchronization performance problems so as to improve synchronization performance of the software code. |
| FILED | Thursday, February 24, 2022 |
| APPL NO | 17/679692 |
| CURRENT CPC | Electric Digital Data Processing G06F 8/458 (20130101) Original (OR) Class G06F 9/524 (20130101) G06F 9/528 (20130101) G06F 9/4856 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230004756 | Chellappan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of South Florida (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sriram Chellappan (Tampa, Florida); Pratool Bharti (Tampa, Florida); Mona Minakshi (Tampa, Florida); Willie McClinton (Tampa, Florida); Jamshidbek Mirzakhalov (Tampa, Florida) |
| ABSTRACT | Identifying insect species integrates image processing, feature selection, unsupervised clustering, and a support vector machine (SVM) learning algorithm for classification. Results with a total of 101 mosquito specimens spread across nine different vector carrying species demonstrate high accuracy in species identification. When implemented as a smart-phone application, the latency and energy consumption were minimal. The currently manual process of species identification and recording can be sped up, while also minimizing the ensuing cognitive workload of personnel. Citizens at large can use the system in their own homes for self-awareness and share insect identification data with public health agencies. |
| FILED | Thursday, September 01, 2022 |
| APPL NO | 17/901494 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6218 (20130101) G06K 9/6228 (20130101) G06K 9/6259 (20130101) Original (OR) Class G06K 9/6269 (20130101) Image or Video Recognition or Understanding G06V 10/22 (20220101) G06V 10/44 (20220101) G06V 10/56 (20220101) G06V 20/30 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230004803 | Hersam et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois); THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark C. Hersam (Wilmette, Illinois); Jiangtan Yuan (Evanston, Illinois); Stephanie E. Liu (Evanston, Illinois); Vinod K. Sangwan (Evanston, Illinois); Amit R. Trivedi (Oak Park, Illinois) |
| ABSTRACT | This invention relates to memtransistors, fabricating methods and applications of the same. The memtransistor includes a polycrystalline monolayer film of an atomically thin material. The polycrystalline monolayer film is grown directly on a sapphire substrate and transferred onto an SiO2/Si substrate; and a gate electrode defined on the SiO2/Si substrate; and source and drain electrodes spatially-apart formed on the polycrystalline monolayer film to define a channel region in the polycrystalline monolayer film therebetween. The gate electrode is capacitively coupled with the channel region. |
| FILED | Wednesday, September 07, 2022 |
| APPL NO | 17/939057 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 45/14 (20130101) H01L 45/16 (20130101) H01L 45/142 (20130101) H01L 45/143 (20130101) H01L 45/144 (20130101) H01L 45/1206 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230006218 | Hall et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anthony Shoji Hall (Baltimore, Maryland); Yunfei Wang (Baltimore, Maryland) |
| ABSTRACT | Metastable alloys have recently emerged as high-performance catalysts, extending the toolbox of binary alloy materials that can be utilized to mediate electrocatalytic reactions. In particular, nanostructured metastable ordered intermetallic compounds are particularly challenging to synthesize. Here the present invention is directed to a method for synthesizing sub-15 nm metastable ordered intermetallic Pd31Bi12 nanoparticles at room temperature, in a single step, by pulsed electrochemical deposition onto high surface area carbon supports. The resulting Pd31Bi12 nanoparticles displays a 7× enhancement of the mass activity relative to Pt/C and a 4× enhancement relative to Pd/C for the oxygen reduction reaction (ORR). The high performance of Pd31Bi12 nanoparticles is demonstrated to arise from reduced oxygen binding caused by alloying of Pd with Bi. The isolation of Pd-sites from each other facilitate methanol tolerant ORR behavior. |
| FILED | Monday, November 23, 2020 |
| APPL NO | 17/779109 |
| CURRENT CPC | Alloys C22C 5/04 (20130101) Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 3/567 (20130101) C25D 5/18 (20130101) C25D 5/54 (20130101) C25D 5/617 (20200801) Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 7/12 (20130101) C30B 29/52 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/921 (20130101) H01M 4/926 (20130101) H01M 4/8853 (20130101) Original (OR) Class H01M 8/1011 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230006871 | Bendlin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | AT and T Intellectual Property I, L.P. (Atlanta, Georgia); University of Notre Dame du Lac (South Bend, Indiana) |
| ASSIGNEE(S) | AT and T Intellectual Property I, L.P. (Atlanta, Georgia); University of Notre Dame du Lac (South Bend, Indiana) |
| INVENTOR(S) | Ralf Bendlin (Cedar Park, Texas); Aditya Chopra (Austin, Texas); Bertrand Martyn Hochwald (South Bend, Indiana); Nicholas Joseph Estes (South Bend, Indiana); Jonathan David Chisum (South Bend, Indiana); Kang Gao (San Diego, California) |
| ABSTRACT | Aspects of the subject disclosure may include, a non-linear energy detector that obtains baseband information from a mixed signal that corresponds to an information component of a received radio frequency (RF) signal, wherein the mixed signal comprises a local oscillator signal combined, without multiplication, with the received RF signal, wherein the received RF signal comprises a carrier wave component operating at a carrier frequency within a millimeter wave spectrum, wherein the non-linear energy detector is associated with a non-linear current-voltage (I-V) characteristic curve, and wherein the baseband information is obtained by applying the mixed signal to the non-linear I-V characteristic curve. Other embodiments are disclosed. |
| FILED | Tuesday, September 13, 2022 |
| APPL NO | 17/943725 |
| CURRENT CPC | Transmission H04B 7/0413 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 27/22 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20230000339 | O'BRIEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Kevin John O'BRIEN (Fort Rucker, Alabama); Victor Alan ESTES (Fort Rucker, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin John O'BRIEN (Fort Rucker, Alabama); Victor Alan ESTES (Fort Rucker, Alabama) |
| ABSTRACT | A glare source device, a glare test system and methods that assesses visual performance and discomfort under varying levels of glare under varying lighting conditions is provided. |
| FILED | Friday, February 21, 2020 |
| APPL NO | 17/432007 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/032 (20130101) Original (OR) Class A61B 3/063 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230001350 | Dai et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sheng Dai (Knoxville, Tennessee); Zhenzhen Yang (Knoxville, Tennessee); Ilja Popovs (Knoxville, Tennessee) |
| ABSTRACT | A crosslinked microporous membrane (crosslinked polymer) composition useful in gas separation, the membrane comprising: (i) an aromatic polymer containing a multiplicity of benzene rings; and (ii) a multiplicity of fluorinated aromatic moieties, each fluorinated aromatic moiety containing at least two separate methylene (—CH2—) linkages connected to benzene rings on the aromatic polymer; wherein the cross-linked microporous membrane possesses micropores having a pore size of up to 2 nm. Also described are methods for producing the crosslinked polymer and a microporous carbon material produced by pyrolysis of the crosslinked polymer membrane. Also described are methods for using the crosslinked polymer and microporous carbon material for gas or liquid separation, filtration, or purification. |
| FILED | Thursday, June 16, 2022 |
| APPL NO | 17/842189 |
| CURRENT CPC | Separation B01D 53/228 (20130101) Original (OR) Class B01D 69/12 (20130101) B01D 71/021 (20130101) B01D 71/28 (20130101) B01D 71/80 (20130101) B01D 71/82 (20130101) B01D 2323/30 (20130101) B01D 2325/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002311 | Jansone-Popova et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Santa Jansone-Popova (Knoxville, Tennessee); Ilja Popovs (Knoxville, Tennessee) |
| ABSTRACT | A method for producing a diglycolamide molecule having the formula: wherein R1 and R2 are independently selected from alkyl groups (R) and acyl groups (C(O)R) in which the alkyl groups (R) contain 1-30 carbon atoms and optionally contain an ether or thioether linkage between carbon atoms, and R5 and R6 are independently selected from hydrogen atom and alkyl groups containing 1-3 carbon atoms; and one or both pairs of R1 and R2 are optionally interconnected to form a ring; the method comprising: combining a diglycolic acid molecule (A) and a secondary amine (B) to form a salt intermediate (C), and heating the salt intermediate (C) to a temperature of 100° C. to 300° C. to form the diglycolamide of Formula (1) in a dehydration process, wherein the method is shown schematically as follows: |
| FILED | Wednesday, June 08, 2022 |
| APPL NO | 17/835028 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 231/02 (20130101) Original (OR) Class Heterocyclic Compounds C07D 207/12 (20130101) C07D 211/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002454 | O'Malley et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michelle A. O'Malley (Santa Barbara, California); Igor A. Podolsky (Goleta, California); Susanna Seppala (Santa Barbara, California) |
| ABSTRACT | The present invention provides for a hybrid sugar transporter having an altered sugar transporter activity and comprising at least a first transmembrane domain (TMD) from a first sugar transporter and a second TMD from a second sugar transporter, wherein the first sugar transporter and the second sugar transporter are heterologous to each other. |
| FILED | Friday, December 10, 2021 |
| APPL NO | 17/548410 |
| CURRENT CPC | Peptides C07K 14/37 (20130101) Original (OR) Class C07K 2319/03 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230003131 | Dai et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhongtao Dai (West Hartford, Connecticut); Ram Ranjan (West Hartford, Connecticut); Robert H. Dold (Monson, Massachusetts) |
| ABSTRACT | A turbine rotor includes a base and a plurality of blades. The base and the blades curve such that radially outward portions of the base and the blades extend in a direction with a greater component in a radial direction than in an axial direction. Radially central portions of the base and the blade extend in a direction with the two components being closer. Radially inner sections of the base and the blades extend in a direction with a greater component in the axial direction than in a radial direction. There is a cooling channel arrangement in the turbine rotor. The cooling channel arrangement includes impingement cooling for a nose and serpentine passages for cooling sections of the platform circumferentially intermediate the blades, and distinct serpentine passages for cooling the plurality of blades. A turbomachine and method are also disclosed. |
| FILED | Friday, July 02, 2021 |
| APPL NO | 17/366493 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 80/00 (20141201) Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/186 (20130101) F01D 5/187 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2230/31 (20130101) F05D 2260/2212 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230003188 | Vermillion et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chris Vermillion (Raleigh, North Carolina); James Christopher Reed (Raleigh, North Carolina); Joshua L. Daniels (Raleigh, North Carolina); Mitchell Cobb (Raleigh, North Carolina); Ayaz Siddiqui (Raleigh, North Carolina) |
| ABSTRACT | Various examples are provided related to kite energy generation. In one example, a method for kite-based energy generation includes deploying a kite in a flow of fluid; controlling movement of the kite along a continuous pattern across the flow, where the kite applies tension greater than a threshold during at least a first portion of the pattern and applies tension less than the threshold during at least a second portion of the pattern; and generating power during the first portion of the continuous pattern. In another example, a system includes a kite including control surfaces that control movement of the kite along a continuous pattern across the flow of fluid; a winch connected to the kite by a tether, and a generator of the winch that can generate power during a portion of the pattern; and a spool controller that can control spooling of the tether during the pattern. |
| FILED | Tuesday, June 28, 2022 |
| APPL NO | 17/851951 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 31/06 (20130101) Wind Motors F03D 5/06 (20130101) Original (OR) Class F03D 9/32 (20160501) F03D 13/20 (20160501) Indexing Scheme Relating to Wind, Spring, Weight, Inertia or Like Motors, to Machines or Engines for Liquids Covered by Subclasses F03B, F03D and F03G F05B 2240/921 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230004803 | Hersam et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois); THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark C. Hersam (Wilmette, Illinois); Jiangtan Yuan (Evanston, Illinois); Stephanie E. Liu (Evanston, Illinois); Vinod K. Sangwan (Evanston, Illinois); Amit R. Trivedi (Oak Park, Illinois) |
| ABSTRACT | This invention relates to memtransistors, fabricating methods and applications of the same. The memtransistor includes a polycrystalline monolayer film of an atomically thin material. The polycrystalline monolayer film is grown directly on a sapphire substrate and transferred onto an SiO2/Si substrate; and a gate electrode defined on the SiO2/Si substrate; and source and drain electrodes spatially-apart formed on the polycrystalline monolayer film to define a channel region in the polycrystalline monolayer film therebetween. The gate electrode is capacitively coupled with the channel region. |
| FILED | Wednesday, September 07, 2022 |
| APPL NO | 17/939057 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 45/14 (20130101) H01L 45/16 (20130101) H01L 45/142 (20130101) H01L 45/143 (20130101) H01L 45/144 (20130101) H01L 45/1206 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20230006133 — METAL-OXIDE INFILTRATED ORGANIC-INORGANIC HYBRID RESISTIVE RANDOM-ACCESS MEMORY DEVICE
| US 20230006133 | Nam et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Brookhaven Science Associates, LLC (Upton, New York); The Research Foundation for The State University of New York (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chang-Yong Nam (Stony Brook, New York); Ashwanth Subramanian (Tualatin, Oregon); Nikhil Tiwale (Medford, New York); Kim Kisslinger (Manorville, New York) |
| ABSTRACT | A resistive random access memory (RRAM) device includes a plurality of memory cells, each of at least a subset of the memory cells including first and second electrodes and an organic thin film compound mixed with silver perchlorate (AgClO4) salt as a base layer that is incorporated with a prescribed quantity of inorganic metal oxide molecules using vapor-phase infiltration (VPI), the base layer being formed on an upper surface of the first electrode and the second electrode being formed on an upper surface of the base layer. Resistive switching characteristics of the RRAM device are controlled as a function of a concentration of AgClO4 salt in the base layer. A variation of device switching parameters is controlled as a function of an amount of infiltrated metal oxide molecules in the base layer. |
| FILED | Thursday, June 30, 2022 |
| APPL NO | 17/854529 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/2463 (20130101) H01L 45/14 (20130101) Original (OR) Class H01L 45/16 (20130101) H01L 45/085 (20130101) H01L 45/1266 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230006214 | KUMTA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania) |
| INVENTOR(S) | Prashant N. KUMTA (Pittsburgh, Pennsylvania); Prasada Rao TALAKONDA (Farmington, Michigan); Moni Kanchan DATTA (Pittsburgh, Pennsylvania); Oleg VELIKOKHATNYI (Pittsburgh, Pennsylvania); Pavithra Murugavel SHANTHI (Pittsburgh, Pennsylvania); Ramalinga KURUBA (Pittsburgh, Pennsylvania) |
| ABSTRACT | The invention relates to complex framework materials (CFMs) for lithium-sulfur batteries. The CFMs include a CFM host and a coating applied to the CFM host, which includes one or more of an electronic conductor, a lithium ion conductor and a functional catalyst. Further, sulfur is infiltrated into the CFM host creating a sulfur-carbon linkage serving as effective anchors for trapping polysulfides. The systems have been tested in coin cells and pouch cells under lean electrolyte conditions of 3-4 μl/mg of electrolyte to sulfur ratios showing promise and feasibility. |
| FILED | Monday, December 14, 2020 |
| APPL NO | 17/781061 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/382 (20130101) H01M 4/663 (20130101) Original (OR) Class H01M 4/5815 (20130101) H01M 10/052 (20130101) H01M 10/647 (20150401) H01M 50/46 (20210101) H01M 2004/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230006229 | Feng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Ruozhu Feng (Richland, Washington); Wei Wang (West Richland, Washington); Xin Zhang (Richland, Washington); Yangang Liang (Richland, Washington); Aaron M. Hollas (Richland, Washington); Yuyan Shao (Richland, Washington); Vijayakumar Murugesan (Richland, Washington); Ying Chen (Richland, Washington) |
| ABSTRACT | Aqueous anolytes for redox flow batteries are disclosed. The anolytes include a fluorenone-fluorenol derivative, an additive comprising an organic compound including one or more proton acceptor groups, an alkali metal hydroxide, and water. The additive functions as a homogeneous organocatalyst and may increase the current density of an aqueous redox flow battery including the anolyte. |
| FILED | Thursday, May 19, 2022 |
| APPL NO | 17/748699 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/08 (20130101) Original (OR) Class H01M 8/188 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20230002086 | Hickerson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sierra Space Corporation (Broomfield, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey S. Hickerson (Erie, Colorado); Mariusz Erni Pecherzewski (Longmont, Colorado); Charles Ralph Sandy (Camden, Delaware); Jeffrey Robert Valania (Erie, Colorado); Grant Robert Woods (Littleton, Colorado) |
| ABSTRACT | Methods, devices, and systems are described for a mounting flange and bracket for a space habitat. The bracket system couples a bladder of a space habitat to a cylindrical core. The bracket system includes a soft goods layer configured to cover the bladder of the space habitat. The bracket system includes a mounting flange configured to couple at an end of the cylindrical core. The mounting flange includes a lip extending around the mounting flange. The bracket system includes a bracket configured to connect the soft goods layer to the mounting flange. The bracket has a first end and a second end. The first end includes a pin configured to couple to the soft goods layer. The second end includes a protrusion configured to latch to the lip of the mounting flange. In some variations, a cap is configured to be coupled to the outer side of the mounting flange. |
| FILED | Friday, April 29, 2022 |
| APPL NO | 17/733769 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/60 (20130101) Original (OR) Class Frames, Casings or Beds of Engines, Machines or Apparatus, Not Specific to Engines, Machines or Apparatus Provided for Elsewhere; Stands; Supports F16M 13/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002937 | GRANBERRY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota); UNITED STATES GOVERNMENT ADMINSTRATOR OF NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rachael GRANBERRY (Saint Paul, Minnesota); Santo PADULA, II (Minneapolis, Minnesota); Bradley HOLSCHUH (North Oaks, Minnesota); Julianna ABEL (Minneapolis, Minnesota); Charles WEINBERG (Minneapolis, Minnesota); Justin BARRY (Minneapolis, Minnesota) |
| ABSTRACT | Yarns incorporating filaments of shape memory materials are described herein that enable the creation of fabrics, garments, and other materials with tunable force absorption or exertion capabilities, as well as creating complex shapes and structures upon actuation. Systems and methods described herein enable selective buckling, recruitment, compression, and other desirable phenomena by actuating fibers in knitted patterns, whether used as isolated filaments or in twisted yarns. |
| FILED | Wednesday, December 02, 2020 |
| APPL NO | 17/756605 |
| CURRENT CPC | Crimping or Curling Fibres, Filaments, Threads, or Yarns; Yarns or Threads D02G 3/441 (20130101) Original (OR) Class Knitting D04B 1/12 (20130101) D04B 1/22 (20130101) Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles D10B 2101/122 (20130101) D10B 2401/046 (20130101) D10B 2501/043 (20130101) D10B 2509/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230003202 | ROBERTS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott N. ROBERTS (Altadena, California); Sean W. REILLY (Pasadena, California); Robert P. DILLON (Costa Mesa, California); Benjamin I. FURST (Pasadena, California); Dan M. GOEBEL (Pasadena, California) |
| ABSTRACT | Systems and methods for embedding a thermal management system in an electric propulsion (EP) system is presented. According to one aspect, one or more oscillating heat pipes (OHPs) are provided within functional elements of the EP system. Each OHP includes channel segments that include a sealed working fluid. The channel segments are joined to form a continuous serpentine channel with a channel path that alternates between hot and cold regions of the EP system. According to another aspect, the functional elements of the EP system are reduced to a single monolithic structure with an embedded OHP. The single monolithic structure may be a single material or a multi material. According to yet another aspect, the functional elements are elements of a magnetic circuit of the EP system, including one or more of a backplate, an outer pole, an inner pole, or a center pole. |
| FILED | Thursday, April 14, 2022 |
| APPL NO | 17/721026 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Producing a Reactive Propulsive Thrust, Not Otherwise Provided for F03H 1/0031 (20130101) Original (OR) Class F03H 1/0075 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20230005146 | Wick et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CAMERAD TECHNOLOGIES (Decatur, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carson A. Wick (Decatur, Georgia); Srini Tridandapani (Decatur, Georgia) |
| ABSTRACT | Methods for identifying a disease state in a patient and/or for treating a patient having the identified disease state are disclosed and can be based on characteristics identified through machine learning models such as deep learning convolutional neural networks and that are associated with video recordings, audio recordings, infrared images, photographs, and/or radiologic patient images. |
| FILED | Friday, September 09, 2022 |
| APPL NO | 17/941993 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230005147 | Wick et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CAMERAD TECHNOLOGIES (Decatur, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carson A. Wick (Decatur, Georgia); Srini Tridandapani (Decatur, Georgia) |
| ABSTRACT | A method for identifying a misidentified study can utilize a set of photographs captured at substantially the same time as a corresponding set of medical images. The method can include determining similarities between the photographs through machine learning models and determining that a misidentified study exists when the similarity between the photographs fails to satisfy a threshold similarity. |
| FILED | Friday, September 09, 2022 |
| APPL NO | 17/942026 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230005349 | Beigel |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Daedalus Technology Group, Inc. (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael L. Beigel (Encinitas, California) |
| ABSTRACT | A system for location of animals and/or objects in an environment includes a signal processing and signal generation system consisting of electromagnetic tags on animals (or other objects) in an environment (typically a three dimension outdoor natural environment) where the animals or objects are physically present at arbitrary locations, and an electro-magnetic signal generating, signal receiving, and signal processing system that can move through or in relation to the environment. The system can compute the location and identity of the animals or objects based on signals received from their associated tags, including the calculated location of the ID tags, which function as “Reader-Locators.” The calculated location is enhanced by information about the environment provided by maps, satellite photos, GPS, GIS and/or other data specific to the probability of the location of the animals or objects within certain regions of the environment. The system includes a physical and electromagnetic modeling operation that is interactive with the environmental information derived from the actual environment, either historically or in “real-time” as the monitoring process occurs. |
| FILED | Monday, September 12, 2022 |
| APPL NO | 17/942962 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 11/006 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 5/02 (20130101) G01S 5/12 (20130101) G01S 5/019 (20200501) G01S 5/0027 (20130101) G01S 5/0284 (20130101) Electric Digital Data Processing G06F 16/29 (20190101) Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 13/2417 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20230000921 | BAJAJ |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VIRGINIA COMMONWEALTH UNIVERSITY (Richmond, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jasmohan BAJAJ (Richmond, Virginia) |
| ABSTRACT | A composition of fecal material is prepared and administered to a subject suffering from alcohol craving, alcohol consumption and/or alcohol use disorder. The donor fecal material is enriched in beneficial microbiota associated with reduced alcohol craving and/or consumption and supplies beneficial microbiota in which the recipient is deficient, and reduces harmful microbes. Methods of preparing and administering are disclosed, along with the identification of beneficial and harmful microbiota families. The treatment is also useful for delivery of microbiota that are short chain fatty acid producers to reduce alcohol craving and/or consumption in subjects deficient in short chain fatty acids. |
| FILED | Monday, November 02, 2020 |
| APPL NO | 17/780728 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/24 (20130101) Original (OR) Class A61K 35/741 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/32 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230002480 | Sajadi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Dongkyoon Kim (Palo Alto, California); Guy Cavet (Hillsborough, California); University of Maryland, Baltimore (Baltimore, Maryland); The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mohammad Sajadi (Cockeysville, Maryland); George K. Lewis (Baltimore, Maryland); Anthony DeVico (Alexandria, Virginia); Dongkyoon Kim (Palo Alto, California); Guy Cavet (Hillsborough, California) |
| ABSTRACT | The present invention provides broadly neutralizing antibodies against HIV, compositions comprising the same and methods of use thereof. |
| FILED | Tuesday, February 22, 2022 |
| APPL NO | 17/677757 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/42 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Peptides C07K 16/1045 (20130101) C07K 16/1063 (20130101) Original (OR) Class C07K 2317/34 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/94 (20130101) C07K 2317/565 (20130101) C07K 2317/732 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20230000967 | GLADUE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | DOUGLAS P. GLADUE (GUILFORD, Connecticut); MANUEL V. BORCA (WESTBROOK, Connecticut) |
| ABSTRACT | Provided herein are details on the construction of a recombinant African Swine Fever Virus (ASFV) live attenuated vaccine for prevention of ASF caused by various strains of ASFV, such as the highly virulent Georgia 2007 isolate (“ASFV-G”). An exemplary vaccine comprises the ASFV-GΔA137R modified virus, a recombinant ASFV-G modified by deleting a portion of the A137R ORF rendering the A137R gene nonfunctional. |
| FILED | Wednesday, June 30, 2021 |
| APPL NO | 17/363875 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class A61K 2039/5254 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/20 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20230005261 | Kolodner et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marc A. Kolodner (Gaithersburg, Maryland); Shea T. Hagstrom (Columbia, Maryland); Leo A. Morris (Severna Park, Maryland) |
| ABSTRACT | A method and a system for object detection over water are provided. The method includes acquiring, from a storage system, image data associated with a target area. The image data includes radiance of a plurality of pixels in a first spectral band and in a second spectral band. The method also includes determining a metric corresponding to a pixel of the plurality of pixels as a function of the radiance in the first spectral band and the radiance in the second spectral band and detecting an object in the target area in response to a determination that the metric satisfies a criteria. |
| FILED | Friday, April 22, 2022 |
| APPL NO | 17/727265 |
| CURRENT CPC | Image or Video Recognition or Understanding G06V 10/764 (20220101) G06V 20/52 (20220101) G06V 20/188 (20220101) G06V 20/194 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of the Interior (DOI)
| US 20230001359 | Qavi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arrowhead Center, Inc. (Las Cruces, New Mexico) |
| ASSIGNEE(S) | Arrowhead Center, Inc. (Las Cruces, New Mexico) |
| INVENTOR(S) | Sahar Qavi (Sugar Land, Texas); Reza Foudazi (Norman, Oklahoma); Aaron Lindsay (Saint Paul, Minnesota) |
| ABSTRACT | A method for in situ production of antimicrobial filtration membranes that uses self-assembly of surfactants such as block copolymers as a template. The mesophase structure (for example hexagonal or lamellar) can be determined, and membrane pore size can be controlled in the nanometer range, by changing the block copolymer and the amounts of the components such as the block copolymer, aqueous solution, monomer, crosslinker, and initiator. The monomer phase cures in the template and there is no need for organic solvents and coagulation bath or other post-modification. As-synthesized membranes were found to have pore sizes with a narrow size distribution in the range of 3-4 nm with a molecular weight cutoff of 1500 g/mol and displayed both excellent fouling resistance and high permeance of water, vastly outperforming a conventional NIPS UF membrane. The monomer can comprise a quaternary ammonium group so that the membrane is antibacterial. The block copolymer can comprise hydrophilic blocks which form the surfaces of the membrane pores, rendering them hydrophilic. |
| FILED | Tuesday, September 06, 2022 |
| APPL NO | 17/903704 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 37/44 (20130101) Separation B01D 67/0006 (20130101) B01D 69/02 (20130101) B01D 69/125 (20130101) Original (OR) Class B01D 71/40 (20130101) B01D 71/52 (20130101) B01D 71/80 (20130101) B01D 2323/08 (20130101) B01D 2323/24 (20130101) B01D 2323/40 (20130101) B01D 2323/345 (20130101) B01D 2325/36 (20130101) B01D 2325/48 (20130101) Compositions of Macromolecular Compounds C08L 33/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20230003325 | Tullius et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jami Frances Tullius (Tuscon, Arizona); David Mutters (Tucson, Arizona); Christopher L. Hernandez (Vail, Arizona); Brian M. Snider-Simon (Tucson, Arizona); Gregory P. Hanauska (Tucson, Arizona) |
| ABSTRACT | A low-profile fluid manifold includes a tunable passive flow control system through intricate internal flow channels. The low-profile fluid manifold is manufactured using stereolithography (SLA) additive manufacturing to rapidly produce and tune the intricate flow channels to achieve the desired flow characteristics. Further, SLA additive manufacturing is used to build up inlet and outlet orifices in the flow direction, creating sealing surfaces for parallel oriented seals and sealing surfaces. The low-profile fluid manifold is manufactured to be air and liquid tight at the required operating pressures, temperatures, and environments, without the use of traditional fittings. |
| FILED | Wednesday, June 30, 2021 |
| APPL NO | 17/305134 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/124 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Fluid Dynamics, i.e Methods or Means for Influencing the Flow of Gases or Liquids F15D 1/025 (20130101) Pipes; Joints or Fittings for Pipes; Supports for Pipes, Cables or Protective Tubing; Means for Thermal Insulation in General F16L 41/03 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230005152 | CHOI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RESEARCH COOPERATION FOUNDATION OF YEUNGNAM UNIVERSITY (Gyeongsangbuk-do, South Korea) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gyu Sang CHOI (Daegu, South Korea); Hyun Kwang SHIN (Gyeongsangbuk-do, South Korea) |
| ABSTRACT | An apparatus for image segmentation according to an embodiment includes an acquirer configured to acquire one or more images in which an object is photographed and a segmentation performer configured to perform segmentation on the one or more images using a segmentation model which is deep learned through a plurality of images, in which the segmentation model is a U-Net-based model including a first type module based on depth-wise separable convolution (DSC) and a second type module based on global context network (GCNet). |
| FILED | Tuesday, April 19, 2022 |
| APPL NO | 17/723767 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) Image Data Processing or Generation, in General G06T 7/10 (20170101) Original (OR) Class G06T 2207/10088 (20130101) G06T 2207/20084 (20130101) G06T 2207/30016 (20130101) G06T 2207/30096 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230005623 | Edwards et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Morgan State University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lorece Edwards (Windsor Mill, Maryland); Lawrence Brown (Baltimore, Maryland); Sabriya Dennis (Abingdon, Maryland); Ian Lindong (Baltimore, Maryland) |
| ABSTRACT | Disclosed is a system and method for predictive risk assessment and intervention including a risk assessment unit that receives survey data from a remotely connected survey device. The survey data comprises information about the social and cultural environment of one or more members of a risk population, including the member's perceptions of their social and environmental factors, the member's demographic data, and optionally publicly available data associated with the member's geographic environment. A predictive risk assessment unit analyzes perceived risk hierarchy inventories to generate a risk portfolio for each surveyed member of the population, which risk portfolio may include a risk predictive quotient profile for each such member assigning a numeric value indicating a likelihood of that member engaging in certain negative activities, a recommendation of interventions that are determined to reduce the likelihood of such member engaging in those negative activities, and preferably a record of success and/or failure of various interventions in reducing that risk. Intervention partners then administer the interventions to the surveyed members, record the success or failure of such intervention in preventing the identified dangerous behavior, and transmit an intervention effectiveness report to the predictive risk assessment unit. The predictive risk assessment unit may then modify and recalibrate the survey instrument and the associated recommended intervention products and tools to maximize the successes of interventions. |
| FILED | Monday, September 12, 2022 |
| APPL NO | 17/942393 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 5/02 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/20 (20180101) G16H 10/60 (20180101) G16H 20/00 (20180101) G16H 50/30 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, January 05, 2023.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20230105.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page