FedInvent™ Patent Applications
Application Details for Thursday, January 26, 2023
This page was updated on Thursday, January 26, 2023 at 12:34 PM GMT
Department of Health and Human Services (HHS)
| US 20230021383 | Lee |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chang Hun Lee (New York, New York) |
| ABSTRACT | Provided herein is a 3D printing system and related compositions, and method of using such, that can produce a polymeric microfiber having embedded microspheres encapsulating an active agent with micron precision and high spatial and temporal resolution. |
| FILED | Monday, June 28, 2021 |
| APPL NO | 17/304890 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) A61L 27/44 (20130101) Original (OR) Class A61L 27/50 (20130101) A61L 27/54 (20130101) A61L 27/56 (20130101) A61L 27/3608 (20130101) A61L 27/3834 (20130101) A61L 27/3847 (20130101) A61L 2300/414 (20130101) A61L 2300/602 (20130101) A61L 2300/622 (20130101) A61L 2430/02 (20130101) A61L 2430/06 (20130101) A61L 2430/10 (20130101) A61L 2430/38 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/112 (20170801) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2067/04 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) B33Y 80/00 (20141201) Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/0007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230021426 | Jin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Indiana University (Bloomington, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jian-Yue Jin (Indianapolis, Indiana); Feng-Ming Kong (Indianapolis, Indiana); Hong Zhang (Wilmington, Delaware); Huan Yao (Indianapolis, Indiana) |
| ABSTRACT | Methods for calculating the radiation dose to the immune system of a patient undergoing radiotherapy are provided. In particular, the methods provide for calculating an effective dose to blood (EDIC) to circulating immune cells. The methods can be incorporated into radiotherapy (RT) treatment planning systems, which are also provided. The methods can be used to optimize patient treatment plans. Methods for treating a patient with RT with an optimized treatment plan are provided. |
| FILED | Thursday, June 16, 2022 |
| APPL NO | 17/842027 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/1031 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230021681 | ELLIOTT |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan T. ELLIOTT (Meriden, New Hampshire) |
| ABSTRACT | Compositions and methods are provided to determine occupancy level of opioid receptors in a subject. The disclosed methods may be performed non-invasively in the inner ear of the subject, and may be performed at a point-of-care location to provide guidance to a practitioner on tapering on pharmacotherapy or on a patient's risk of relapse for substance abuse. |
| FILED | Wednesday, November 11, 2020 |
| APPL NO | 17/776242 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/485 (20130101) A61K 49/0045 (20130101) Peptides C07K 7/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230021837 | MATHEW et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MESO SCALE TECHNOLOGIES, LLC. (Rockville, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anu MATHEW (North Potomac, Maryland); Mingyue WANG (Potomac, Maryland); Christopher CAMPBELL (Columbia, Maryland); Katarzyna HAYNESWORTH (Buckeystown, Maryland); Nikhil PADMANABHAN (McLean, Virginia); Martin STENGELIN (Gaithersburg, Maryland); Paridhi GUPTA (Boyds, Maryland); Rashmi SRIRAM (Gaithersburg, Maryland) |
| ABSTRACT | The invention relates to assay methods and kits for assessing autoimmune diseases in a human subject. In embodiments, the present disclosure provides assay methods and kits for diagnosing a subject with or predicting that a subject will develop Type 1 diabetes. In embodiments, the present disclosure provides assay methods and kits for assessing responsiveness of a subject having Type 1 diabetes to treatment with alefacept. In embodiments, the present disclosure provides assay methods and kits for diagnosing a subject with systemic lupus erythematosus. In embodiments, the present disclosure provides assay methods and kits for determining if a subject is at risk of a systemic lupus erythematosus flare. In embodiments, the present disclosure provides assay methods and kits for diagnosing a subject with celiac disease. |
| FILED | Wednesday, November 25, 2020 |
| APPL NO | 17/779900 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/543 (20130101) G01N 33/564 (20130101) Original (OR) Class G01N 2800/24 (20130101) G01N 2800/042 (20130101) G01N 2800/52 (20130101) G01N 2800/104 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230022117 | SHA |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (CHARLESTON, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Suhua SHA (Mt. Pleasant, South Carolina) |
| ABSTRACT | Described herein are compositions capable of targeting CaMKKβ and/or AMPK alpha and formulations thereof. Also described herein are methods of using the compositions and formulations thereof. In some embodiments, the compositions capable of targeting CaMKKβ and/or AMPK alpha and formulations thereof can prevent or treat outer hair cell loss, such as that which can occur as a result of auditory or chemical insult. In some embodiments, the compositions capable of targeting CaMKKβ and/or AMPK alpha and formulations thereof can treat or prevent acquired hearing loss. |
| FILED | Friday, December 04, 2020 |
| APPL NO | 17/782611 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/16 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230022304 | Chacon Simon et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Selena Chacon Simon (Nashville, Tennessee); Alex Waterson (Nashville, Tennessee); Jonathan D. MacDonald (Nashville, Tennessee); Stephen Fesik (Nashville, Tennessee); Shaun R. Stauffer (Brentwood, Tennessee); William P. Tansey (Brentwood, Tennessee) |
| ABSTRACT | Substituted N-heteroaryl sulfonamide compounds inhibit WDR5-MYC interactions, and the compounds and their pharmaceutical compositions are useful for treating disorders and conditions in a subject such as cancer cell proliferation. |
| FILED | Wednesday, November 18, 2020 |
| APPL NO | 17/777686 |
| CURRENT CPC | Heterocyclic Compounds C07D 231/42 (20130101) C07D 233/88 (20130101) Original (OR) Class C07D 249/14 (20130101) C07D 277/54 (20130101) C07D 277/82 (20130101) C07D 401/12 (20130101) C07D 403/04 (20130101) C07D 403/06 (20130101) C07D 403/12 (20130101) C07D 405/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230022311 | SANJANA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NEW YORK GENOME CENTER, INC (New York, New York); NEW YORK UNIVERSITY (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Neville E. SANJANA (New York, New York); Hans-Hermann WESSELS (Brooklyn, New York); Alejandro MENDEZ-MANCILLA (New York, New York) |
| ABSTRACT | A Class 2, Type VI clustered regularly interspaced short palindromic repeat (CRISPR) RNA (crRNA) which comprises a direct repeat (DR) stem loop sequence and a guide or spacer sequence, is provided characterized by a DR selected from those of Table 9. Also described is are methods for generating, selecting, characterizing and optimizing a clustered regularly interspaced short palindromic repeats (CRISPR) RNA (crRNA) for use in the CRISPR-Cas13d system described herein. Also provided is a screening method to identify crRNA particularly suited for use with specified targets. Further, the invention includes non-naturally occurring, synthesized or engineered crRNAs as described herein along with nucleic acid molecule, vectors, RNPs, cells, libraries, and compositions comprising the same, and uses thereof in treating a disease or in functionally screening a gene. A method for blocking an RNA target without degradation and a method for modification of multiple RNA targets using the same CRISPR effector protein are also disclosed. |
| FILED | Wednesday, November 25, 2020 |
| APPL NO | 17/756459 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2320/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230022411 | Eavarone et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Seagen Inc. (Bothell, Washington); The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | Seagen Inc. (Bothell, Washington); The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | David A. Eavarone (North Quincy, Massachusetts); Julie DeSander (Arlington, Massachusetts); Jeffrey Behrens (Newton, Massachusetts); Bo R. Rueda (Windham, New Hampshire); Rosemary Foster (Arlington, Massachusetts); Kristen D. Starbuck (Amherst, New York) |
| ABSTRACT | The present invention provides methods of testing anti-STn antibodies for their ability target cancer stem cells by isolating cancer stem cells from cultures, contacting them with anti-STn antibodies being tested, and measuring resulting cell viability. |
| FILED | Wednesday, March 16, 2022 |
| APPL NO | 17/696184 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6803 (20170801) A61K 47/6869 (20170801) A61K 2039/505 (20130101) Peptides C07K 16/3069 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57492 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230022513 | HAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Crinetics Pharmaceuticals, Inc. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sangdon HAN (San Diego, California); Sun Hee KIM (San Diego, California); Yunfei ZHU (San Diego, California) |
| ABSTRACT | Described herein are compounds that are somatostatin modulators, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders that would benefit from modulation of somatostatin activity. |
| FILED | Wednesday, April 06, 2022 |
| APPL NO | 17/714825 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/08 (20130101) A61K 9/2013 (20130101) A61K 9/2054 (20130101) A61K 9/4825 (20130101) Heterocyclic Compounds C07D 401/14 (20130101) C07D 498/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230022632 | Yang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Rochester (Rochester, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qiang Yang (Rochester, New York); Jennifer Hunter (Rochester, New York); Keith Parkins (Rochester, New York) |
| ABSTRACT | A microscopy imaging system comprises a fluorescence lifetime imaging microscopy (FLIM) system comprising a pulsed light source configured to direct a plurality of excitation light pulses onto a sample, a photo detector configured to detect emitted fluorescent photons created by the plurality of excitation pulses interacting with the sample, and a FLIM data acquisition system configured to measure the time interval between the excitation light pulses and the detected emitted fluorescent photons, a scanning light microscopy (SLM) system comprising a SLM data acquisition system, a fast scanning mirror and a slow scanning mirror, wherein the mirrors are configured to scan the light pulses across the sample; and a data processing system communicatively connected to the FLIM and SLM systems. Microscopy imaging methods are also disclosed. |
| FILED | Thursday, July 14, 2022 |
| APPL NO | 17/812494 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/12 (20130101) A61B 3/13 (20130101) Original (OR) Class Optical Elements, Systems, or Apparatus G02B 21/16 (20130101) G02B 21/0048 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230022767 | Morris et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC (Bethesda, Maryland); THE UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Patrick Joseph Morris (Gaithersburg, Maryland); Craig Joseph Thomas (Laurel, Maryland); Stephen J. Byard (Morpeth, Northumberland, United Kingdom); Martin P. Wilmshurst (Alnwick, Northumberland, United Kingdom); Todd Gould (Elkridge, Maryland); Carlos Zarate (Germantown, Maryland); Ruin Moaddel (Bel Air, Maryland) |
| ABSTRACT | The disclosure provides salts of (2R,6R)-hydroxynorketamine (HNK), wherein the salt is with an organic acid chosen from malonic acid, salicylic acid, ethane sulfonic acid, glycolic acid, stearic acid, or capric acid, and their crystal forms. |
| FILED | Tuesday, November 17, 2020 |
| APPL NO | 17/777654 |
| CURRENT CPC | General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/13 (20130101) Acyclic or Carbocyclic Compounds C07C 225/20 (20130101) Original (OR) Class C07C 2601/14 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230023122 | Leuthardt et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric Leuthardt (St. Louis, Missouri); Bidhan Lamichhane (St. Louis, Missouri) |
| ABSTRACT | The present disclosure is directed to methods of predicting overall survival, monitoring, and selecting treatments for a glioblastoma (GBM) patient. The method of the present disclosure includes obtaining at least one morphometric image from the GBM patient, identifying at least one radiomic biomarker based on the at least one morphometric image, and determining an overall survival value based on the at least one radiomic biomarker. |
| FILED | Friday, July 15, 2022 |
| APPL NO | 17/866246 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0042 (20130101) A61B 5/055 (20130101) A61B 5/1072 (20130101) A61B 5/1073 (20130101) A61B 5/4064 (20130101) A61B 5/7275 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230023217 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Worcester Polytechnic Institute (Worcester, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Haichong Zhang (Shrewsbury, Massachusetts); Shang Gao (Worcester, Massachusetts) |
| ABSTRACT | A photoacoustic imaging approach identifies, concurrently with ablation therapy, an extent of the ablation by measuring and rendering a necrotic extent of treated tissue in a treatment region. Laser pulsed light directed at the treatment region induces an acoustic (ultrasound) signal for differentiating ablated tissue from its non-ablative counterpart based on a photoacoustic spectrum variation. The acoustic signal indicates a range of necrotic extent based on a quantified ablated tissue contrast and a total contrast of both necrotic and non-necrotic tissue, defined as a fraction for computing a degree of necrosis. Generation of an image indicating the degree of necrosis allows continuous or near continuous feedback for ablation therapy guidance to ensure complete and effective ablation of the proper tissue in the treatment region. |
| FILED | Wednesday, July 20, 2022 |
| APPL NO | 17/869130 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0036 (20180801) A61B 5/0084 (20130101) A61B 5/0095 (20130101) Original (OR) Class A61B 2018/00577 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230023536 | CHIU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (Seattle, Washington) |
| ASSIGNEE(S) | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (Seattle, Washington) |
| INVENTOR(S) | Daniel T. CHIU (Seattle, Washington); Mengxia ZHAO (Seattle, Washington); Wyatt NELSON (Seattle, Washington); Perry G. SCHIRO (Seattle, Washington) |
| ABSTRACT | Provided herein, among other aspects, are methods and apparatuses for analyzing particles in a sample. In some aspects, the particles can be analytes, cells, nucleic acids, or proteins and contacted with a tag, partitioned into aliquots, detected by a ranking device, and isolated. The methods and apparatuses provided herein may include a microfluidic chip. In some aspects, the methods and apparatuses may be used to quantify rare particles in a sample, such as cancer cells and other rare cells for disease diagnosis, prognosis, or treatment. |
| FILED | Friday, September 16, 2022 |
| APPL NO | 17/932687 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/561 (20130101) B01L 3/567 (20130101) B01L 3/502761 (20130101) B01L 2200/0673 (20130101) B01L 2300/0864 (20130101) B01L 2400/0415 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/0612 (20130101) G01N 15/0656 (20130101) G01N 15/1456 (20130101) G01N 15/1484 (20130101) G01N 21/6428 (20130101) G01N 21/6456 (20130101) G01N 33/49 (20130101) G01N 33/5304 (20130101) G01N 33/57492 (20130101) Original (OR) Class G01N 2015/0693 (20130101) G01N 2035/1034 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230023592 | Kim et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Young L. Kim (West Lafayette, Indiana); Md Munirul Haque (Fishers, Indiana); Michelle Amaris Visbal-Onufrak (Las Piedras, Puerto Rico); Sang Mok Park (West Lafayette, Indiana) |
| ABSTRACT | A bloodless system for numerically generated hyperspectral imaging data for measuring biochemical compositions is disclosed which includes an optical imaging device adapted to acquire an RGB image from an area of interest, a processor adapted to receive a hyperspectral dataset representing an a priori hyperspectral data of the area of interest of a population to which the subject belongs, receive RGB response for each one of RGB channels of the optical imaging device, pair the corresponding RGB data with the hyperspectral data, obtain a transformation matrix adapted to convert a subject-specific RGB image dataset into a subject-specific hyperspectral dataset for the optical imaging device, receive a subject- specific RGB dataset, generate a subject- specific hyperspectral dataset using the transformation matrix, and compute a blood hemoglobin level of the subject from the generated subject-specific hyperspectral dataset. |
| FILED | Tuesday, November 24, 2020 |
| APPL NO | 17/779497 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/1455 (20130101) A61B 5/7267 (20130101) A61B 5/14546 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230023607 | Wang |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wei Wang (Tucson, Arizona) |
| ABSTRACT | Disclosed are a deuterated compound of fomula (I), or a salt thereof, and methods for preparation thereof. The present disclosure may provide a mild, versatile organophotoredox method for the preparation of diverse, enantioenriched α-deuterated α-amino acids. In particular, the present disclosure may address the long-standing challenge of installing sterically demanding side chains into α-amino acids, including late-stage modifications on medicinal agents and natural products. |
| FILED | Thursday, February 04, 2021 |
| APPL NO | 17/790831 |
| CURRENT CPC | General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/05 (20130101) Heterocyclic Compounds C07D 263/26 (20130101) C07D 413/06 (20130101) C07D 493/04 (20130101) Original (OR) Class C07D 493/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230023616 | Levin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Levin (Beverly, Massachusetts); David L. Kaplan (Concord, Massachusetts); Nirosha J. Murugan (Medford, Massachusetts) |
| ABSTRACT | Disclosed are apparatus, compositions, and methods for promoting regeneration of tissue on a subject such as a wounded, damaged, or injured appendage, or within a subject such as a wounded, damaged, or injured organ. The disclosed apparatus, composition, and methods include or utilize wearable sleeves and regenerative compositions. |
| FILED | Monday, December 07, 2020 |
| APPL NO | 17/782945 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/0077 (20130101) A61F 2/80 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/54 (20130101) A61L 27/56 (20130101) Original (OR) Class A61L 27/227 (20130101) A61L 27/3637 (20130101) A61L 2300/21 (20130101) A61L 2300/43 (20130101) A61L 2300/204 (20130101) A61L 2300/252 (20130101) A61L 2300/428 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/326 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230023741 | Handique |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HANDYLAB, INC. (Franklin Lakes, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kalyan Handique (Ypsilanti, Michigan) |
| ABSTRACT | Disclosed herein are devices configured for the amplification and detection of multiple targets from a sample, and methods of using the same. The devices disclosed herein comprise microfluidic cartridges have a first stage (amplification) and a second (detection) stage. The two-stage design of the cartridges enables testing for multiple targets within a sample, i.e., from a single nucleic acid amplification reaction. Methods for the amplification and detection of a plurality of target nucleic acids from a sample are also disclosed herein. |
| FILED | Thursday, September 22, 2022 |
| APPL NO | 17/934351 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5027 (20130101) B01L 3/502723 (20130101) B01L 3/502738 (20130101) B01L 7/52 (20130101) B01L 2200/10 (20130101) B01L 2200/027 (20130101) B01L 2200/0684 (20130101) B01L 2300/0816 (20130101) B01L 2400/06 (20130101) B01L 2400/0677 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 99/0036 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230023802 | Sizovs et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE METHODIST HOSPITAL SYSTEM (Houston, Texas) |
| ASSIGNEE(S) | THE METHODIST HOSPITAL SYSTEM (Houston, Texas) |
| INVENTOR(S) | Antons Sizovs (Riga, Latvia); Fernanda Paola Pons Faudoa (Houston, Texas); Alessandro Grattoni (Houston, Texas) |
| ABSTRACT | The present disclosure provides solid drug formulations, in particular to stabilized formulations of phosphonamidate-containing drugs, as well as methods for loading drug delivery devices with solid formulations. |
| FILED | Monday, December 07, 2020 |
| APPL NO | 17/756859 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/08 (20130101) A61K 9/0024 (20130101) Original (OR) Class A61K 31/675 (20130101) A61K 47/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230023922 | Witchger, JR. et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Translational Imaging Innovations, Inc. (Hickory, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew J. Witchger, JR. (Durham, North Carolina); Robert C. Williams (Durham, North Carolina); Alexander E. Salmon (Garner, North Carolina); Maureen E. Tuffnell (Wauwatosa, Wisconsin); Taylor M. Szeto (Cary, North Carolina); Tammy B. Carrea (Raleigh, North Carolina); Eric L. Buckland (Hickory, North Carolina) |
| ABSTRACT | An application programming interface (API) resident on a computer is provided that, upon receiving a message that a data set associated with an encounter experienced by a subject is available, causes a processor to read a structured file associated with the data set, the structured file having a set of records assigned to a subset of pre-defined fields and a location of one or more unstructured objects, the pre-defined fields being organized according to an ontology having at least records related to the subject, the encounter and the data set; and populate at least first and second independent and distinct relational databases using endpoints of the API. The first relational database excludes records associated with the subject and the encounter and the second relational database includes records associated with the subject and the encounter. The second relational database includes multiple tables that can be accessed by invoking the API. |
| FILED | Thursday, July 21, 2022 |
| APPL NO | 17/870317 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/258 (20190101) G06F 21/6245 (20130101) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/20 (20180101) G16H 30/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230024038 | Jorabchi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgetown University (Washington, District of Columbia) |
| ASSIGNEE(S) | Georgetown University (Washington, District of Columbia) |
| INVENTOR(S) | Kaveh Jorabchi (Arlington, Virginia); Joseph Lesniewski (Washington, District of Columbia); Kunyu Zheng (Washington, District of Columbia); Samuel White (Washington, District of Columbia) |
| ABSTRACT | A method that includes introducing at least one analyte into a gas plasma; generating neutral species from atoms of the analyte in the gas plasma; preferentially transporting the neutral species downstream of the gas plasma relative to any ions produced in the gas plasma; and reacting the neutral species of the analyte with at least one reagent ion downstream of the plasma resulting in ion species of the analyte, wherein the at least one reagent ion is supplied by an independent ion source. |
| FILED | Thursday, February 25, 2021 |
| APPL NO | 17/785838 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/726 (20130101) G01N 30/7206 (20130101) G01N 30/7266 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/005 (20130101) Original (OR) Class H01J 49/0077 (20130101) H01J 49/105 (20130101) H01J 49/165 (20130101) H01J 49/168 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230024046 | Choe et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California); Boyce Thompson Institute for Plant Research (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrea Choe (Pasadena, California); Paul W. Sternberg (San Marino, California); Frank C. Schroeder (Ithaca, New York); Stephan H. Von Reuss (Jena, Germany) |
| ABSTRACT | The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. In one embodiment, the present invention provides a method of treating an immune and inflammatory disorders disorder by administering a composition comprising a therapeutically effective dosage of an ascaroside compound, or a mixture of ascaroside compounds, or a mixture containing at least one ascaroside. |
| FILED | Monday, August 01, 2022 |
| APPL NO | 17/878650 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 37/36 (20130101) A01N 43/16 (20130101) A01N 43/38 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/454 (20130101) A61K 31/7028 (20130101) Heterocyclic Compounds C07D 309/10 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 15/04 (20130101) Original (OR) Class C07H 15/08 (20130101) C07H 15/10 (20130101) C07H 15/18 (20130101) C07H 15/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20230024072 — Millimeter-Scale Chip-Based Supercontinuum Generation For Optical Coherence Tomography
| US 20230024072 | Ji et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xingchen Ji (New York, New York); Michal Lipson (New York, New York); Diana Mojahed (New York, New York); Yoshitomo Okawachi (River Edge, New Jersey); Christine P Hendon (Bronx, New York); Alexander L Gaeta (New York, New York) |
| ABSTRACT | Methods, systems, and devices are described for generating an optical signal. An example device may comprise a chip and a waveguide disposed on the chip and comprising silicon nitride. The waveguide may be configured to generate, based on nonlinear effects applied to a pump signal from a pump laser, an optical signal having a broader spectrum than the pump signal. The waveguide may have a width and a height such that the optical signal has near zero group-velocity-dispersion. |
| FILED | Wednesday, July 13, 2022 |
| APPL NO | 17/812196 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0066 (20130101) Optical Elements, Systems, or Apparatus G02B 6/1225 (20130101) G02B 2006/12061 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/365 (20130101) G02F 1/3528 (20210101) Original (OR) Class Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/0092 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230024240 | GURNEY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Tetra Discovery Partners, LLC (Grand Rapids, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark E. GURNEY (Grand Rapids, Michigan); Timothy J. HAGEN (Lisle, Illinois); Xuesheng MO (Naperville, Illinois); A. Samuel VELLEKOOP (Altamont, New York); Donna L. ROMERO (Chesterfield, Missouri); Robert CAMPBELL (Niskayuna, New York); Joel R. WALKER (Schenectady, New York); Lei ZHU (Schenectady, New York) |
| ABSTRACT | The present invention relates to compounds and methods useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators. |
| FILED | Thursday, June 23, 2022 |
| APPL NO | 17/808439 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/44 (20130101) A61K 31/53 (20130101) A61K 31/69 (20130101) A61K 31/435 (20130101) A61K 31/496 (20130101) A61K 31/505 (20130101) A61K 31/506 (20130101) A61K 31/517 (20130101) A61K 31/519 (20130101) A61K 31/4418 (20130101) A61K 31/5377 (20130101) A61K 45/06 (20130101) Heterocyclic Compounds C07D 213/56 (20130101) C07D 213/72 (20130101) C07D 213/74 (20130101) C07D 221/04 (20130101) C07D 239/26 (20130101) C07D 239/70 (20130101) C07D 251/22 (20130101) C07D 251/30 (20130101) C07D 251/42 (20130101) C07D 401/04 (20130101) C07D 401/12 (20130101) C07D 403/12 (20130101) C07D 405/04 (20130101) C07D 409/04 (20130101) C07D 409/14 (20130101) C07D 413/12 (20130101) C07D 413/14 (20130101) C07D 495/04 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/025 (20130101) C07F 5/027 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230024401 | Shen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Liyue Shen (Cambridge, Massachusetts); Lei Xing (Palo Alto, California) |
| ABSTRACT | A method for diagnostic imaging reconstruction uses a prior image xpr from a scan of a subject to initialize parameters of a neural network which maps coordinates in image space to corresponding intensity values in the prior image. The parameters are initialized by minimizing an objective function representing a difference between intensity values of the prior image and predicted intensity values output from the neural network. The neural network is then trained using subsampled (sparse) measurements of the subject to learn a neural representation of a reconstructed image. The training includes minimizing an objective function representing a difference between the subsampled measurements and a forward model applied to predicted image intensity values output from the neural network. Image intensity values output from the trained neural network from coordinates in image space input to the trained neural network are computed to produce predicted image intensity values. |
| FILED | Wednesday, September 14, 2022 |
| APPL NO | 17/944709 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Image Data Processing or Generation, in General G06T 11/005 (20130101) G06T 11/006 (20130101) Original (OR) Class G06T 2210/41 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230024508 | Steinmetz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio); Trustees of Dartmouth College (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicole F. Steinmetz (Cleveland, Ohio); Amy M. Wen (Cleveland, Ohio); Steven Fiering (Hanover, New Hampshire); Patrick H. Lizotte (Cleveland, Ohio) |
| ABSTRACT | A method of treating cancer in a subject in need thereof includes administering in situ to the cancer a therapeutically effective amount of a virus or virus-like particle. |
| FILED | Friday, February 25, 2022 |
| APPL NO | 17/680813 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/704 (20130101) A61K 39/12 (20130101) Original (OR) Class A61K 2039/5258 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 35/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230024540 | Sherlock et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Benjamin E. Sherlock (Davis, California); Diego R. Yankelevich (Davis, California); Julien Bec (Davis, California); Laura Marcu (Davis, California) |
| ABSTRACT | The disclosed embodiments relate to multimodal imaging system comprising a fiber-coupled fluorescence imaging system, which operates based on ultra-violet (UV) excitation light, and a fiber-coupled optical coherence tomography (OCT) imaging system. The multimodal imaging system also includes a fiber optic interface comprising a single optical fiber, which facilitates light delivery to a sample-of-interest and collection of returned optical signals for both the fluorescence imaging system and the OCT imaging system. During operation of the system, the single optical fiber carries both UV light and coherent infrared light through two concentric light-guiding regions, thereby facilitating generation of precisely co-registered optical data from the fluorescence imaging system and the OCT imaging system. |
| FILED | Thursday, September 22, 2022 |
| APPL NO | 17/950994 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/102 (20130101) A61B 5/0066 (20130101) A61B 5/0086 (20130101) Original (OR) Class Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/02091 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230024611 | Zeng |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Kansas (Lawrence, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yong Zeng (Gainesville, Florida) |
| ABSTRACT | Provided herein are methods for inkjet printing objects, including objects which may be used as elements of microfluidic devices. The microfluidic devices incorporating the elements are also provided. Such microfluidic devices include those configured to quantify the expression and activity of exosomal matrix metalloprotease, MMP14. These microfluidic devices may be used in methods of monitoring breast cancer in patients having breast cancer. |
| FILED | Tuesday, March 02, 2021 |
| APPL NO | 17/791079 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/37 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 21/6456 (20130101) G01N 33/6872 (20130101) G01N 33/54386 (20130101) G01N 33/57484 (20130101) Original (OR) Class G01N 2021/6432 (20130101) G01N 2021/6439 (20130101) G01N 2333/70596 (20130101) G01N 2333/96494 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230024795 | Otvos et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | LipoScience, Inc. (Morrisville, North Carolina); National Institutes of Health (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James D. Otvos (Apex, North Carolina); Irina Shalaurova (Cary, North Carolina); Alan Remaley (Bethesda, Maryland); Maureen Sampson (Silver Spring, Maryland); Lita Freeman (Bethesda, Maryland) |
| ABSTRACT | Described herein are methods and systems for the determination of constituents in biosamples by NMR spectroscopy and more specifically for the determination of lipoprotein constituents LP-X, LP-Y, and LP-Z in blood plasma and serum. |
| FILED | Monday, September 19, 2022 |
| APPL NO | 17/947738 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 24/00 (20130101) G01N 33/92 (20130101) Original (OR) Class G01N 35/00693 (20130101) G01N 2035/00702 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230024833 | Joung et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | J. Keith Joung (Winchester, Massachusetts); James Angstman (Boston, Massachusetts) |
| ABSTRACT | Provided herein are compositions and methods for improving the genome-wide specificities of targeted base editing technologies. |
| FILED | Friday, December 04, 2020 |
| APPL NO | 17/781500 |
| CURRENT CPC | Peptides C07K 14/001 (20130101) C07K 2319/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0647 (20130101) C12N 9/22 (20130101) C12N 9/78 (20130101) Original (OR) Class C12N 15/11 (20130101) C12N 15/625 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) Enzymes C12Y 305/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230024914 | Raffay et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas M. Raffay (Cleveland, Ohio); Benjamin M. Gaston (Cleveland, Ohio) |
| ABSTRACT | A method of treating a hyperoxia induced disease or disorder associated with GSNO deficiency in a subject in need thereof includes administering to the subject a therapeutically effective amount of GSNO or a GSNO promoting agent. |
| FILED | Tuesday, July 19, 2022 |
| APPL NO | 17/868106 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0078 (20130101) A61K 31/4178 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230025038 | Nabel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| INVENTOR(S) | Gary J. Nabel (Chestnut Hill, Massachusetts); Wataru Akahata (Kensington, Maryland); Srinivas Rao (Columbia, Maryland) |
| ABSTRACT | The invention features compositions and methods for the prevention or treatment of one or more strains of Chikungunya virus, as well as other alphavirus-mediated diseases. |
| FILED | Monday, June 27, 2022 |
| APPL NO | 17/850706 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class A61K 2039/5258 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 7/045 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230025039 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| INVENTOR(S) | Feng Zhang (Cambridge, Massachusetts); Han Altae-Tran (Cambridge, Massachusetts); Soumya Kannan (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides Cas proteins and their use in modifying target sequences. |
| FILED | Friday, September 18, 2020 |
| APPL NO | 17/761292 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 9/78 (20130101) C12N 15/11 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) Enzymes C12Y 305/04004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230025256 | FRIEDMAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SIMON FRIEDMAN (KANSAS CITY, Missouri); SWETHA CHINTALA (KANSAS CITY, Missouri); MAYANK SHARMA (KANSAS CITY, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | SIMON FRIEDMAN (KANSAS CITY, Missouri); SWETHA CHINTALA (KANSAS CITY, Missouri); MAYANK SHARMA (KANSAS CITY, Missouri) |
| ABSTRACT | Certain aspects of the present invention are directed to a method for making a protein blocking assembly reversibly linking a therapeutic protein to a blocking group via a linker moiety. Additional aspects of the invention are directed to the protein blocking assembly, and to methods of administering the protein blocking assembly to a subject, where the protein is cleaved from the protein blocking assembly. |
| FILED | Thursday, December 03, 2020 |
| APPL NO | 17/782717 |
| CURRENT CPC | Peptides C07K 14/62 (20130101) C07K 14/605 (20130101) Original (OR) Class C07K 14/70503 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230025280 | ZHAO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ONCONANO MEDICINE, INC (Southlake, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tian ZHAO (Southlake, Texas); Yalia JAYALAKSHMI (Southlake, Texas); Keith A. HALL (Southlake, Texas); Brian MADAJEWSKI (Southlake, Texas); Hargita KAPLAN (Southlake, Texas) |
| ABSTRACT | Described herein are formulations, methods, and pH responsive compositions useful for the detection of primary and metastatic tumor tissues. |
| FILED | Tuesday, November 17, 2020 |
| APPL NO | 17/756190 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/0054 (20130101) Original (OR) Class A61K 49/0082 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/84 (20130101) G01N 33/582 (20130101) G01N 2800/7028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230025360 | Mehrotra et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MUSC Foundation for Research Development (Charleston, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shikhar Mehrotra (Mount Pleasant, South Carolina); Pravin Kesarwani (Royal Oak, Michigan); Shilpak Chatterjee (Charleston, South Carolina) |
| ABSTRACT | The present invention relates to an adoptive T cell therapy using cells generated by genetically or biochemically reprogramming T cells to produce T memory stem cells (Tscm) that persist longer in vivo and are superior anti-tumor effector cells. |
| FILED | Wednesday, August 03, 2022 |
| APPL NO | 17/817125 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/381 (20130101) A61K 31/401 (20130101) A61K 35/17 (20130101) Original (OR) Class A61K 38/43 (20130101) A61K 38/063 (20130101) A61K 38/2026 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230025400 | McAlpine et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael C. McAlpine (Minneapolis, Minnesota); Guebum Han (Minneapolis, Minnesota); John C. Bischof (Saint Paul, Minnesota); Kanav Khosla (St Paul, Minnesota); Kieran T. Smith (Minneapolis, Minnesota) |
| ABSTRACT | A system includes a placement head with at least one printing nozzle configured to pick up and detachably hold at least one biological organism; an image acquisition system including a visual inspection system configured to identify at least one target biological organism to be picked up by the printing nozzle of the placement head in a first location, and identify at least one second location for deposit of the at least one target biological organism, wherein the first location is different from the at least one second location; and a robotic motion system that moves the placement head, based on input from the visual inspection system and a distance identification system, from the first location to the at least one second location, such that the placement head deposits the target biological organism at the at least one second location. |
| FILED | Wednesday, July 20, 2022 |
| APPL NO | 17/813779 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/209 (20170801) B29C 64/393 (20170801) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 50/02 (20141201) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0062 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230025608 | Hunt et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia); The University of Birmingham (Birmingham, United Kingdom) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia); The University of Birmingham (Birmingham, United Kingdom) |
| INVENTOR(S) | Donald F. Hunt (Charlottesville, Virginia); Jeffrey Shabanowitz (Charlottesville, Virginia); Stacy Alyse Malaker (Menlo Park, California); Victor H. Engelhard (Crozet, Virginia); Angela L. Ambakhutwala (Glen Allen, Virginia); Kara L. Cummings (Charlottesville, Virginia); Rebecca C. Obeng (Charlottesville, Virginia); Mark Cobbold (Winchester, Massachusetts) |
| ABSTRACT | A set of target peptides are presented by HLA A*0101, A*0201, A*0301, B*4402, B*2705, B*1402, and B*0702 on the surface of disease cells. They are envisioned to among other things (a) stimulate an immune response to the proliferative disease, e.g., cancer, (b) to function as immunotherapeutics in adoptive T cell therapy or as a vaccine, (c) facilitate antibody recognition of tumor boundaries in surgical pathology samples, (d) act as biomarkers for early detection and/or diagnosis of the disease, and (e) act as targets in the generation antibody-like molecules which recognize the target-peptide/MHC complex. |
| FILED | Monday, February 08, 2021 |
| APPL NO | 17/170044 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/15 (20130101) A61K 35/17 (20130101) A61K 39/0011 (20130101) Original (OR) Class A61K 39/00111 (20180801) A61K 39/00119 (20180801) A61K 39/001106 (20180801) A61K 39/001113 (20180801) A61K 39/001132 (20180801) A61K 39/001151 (20180801) A61K 39/001156 (20180801) A61K 39/001157 (20180801) A61K 39/001162 (20180801) A61K 39/001164 (20180801) A61K 39/001166 (20180801) A61K 39/001181 (20180801) A61K 39/001182 (20180801) A61K 39/001184 (20180801) A61K 39/001186 (20180801) A61K 39/001188 (20180801) A61K 39/001189 (20180801) A61K 39/001192 (20180801) A61K 39/001193 (20180801) A61K 39/001194 (20180801) A61K 39/001195 (20180801) A61K 39/001197 (20180801) A61K 45/06 (20130101) A61K 2039/57 (20130101) A61K 2039/5154 (20130101) A61K 2039/5158 (20130101) A61K 2039/55516 (20130101) Peptides C07K 16/2809 (20130101) C07K 16/2833 (20130101) C07K 2317/31 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6863 (20130101) G01N 33/57496 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230025694 | Lakowicz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University Of Maryland, Baltimore (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph R. Lakowicz (Ellicott City, Maryland); Ramachandram Badugu (Ellicott City, Maryland); E. Albert Reece (Lutherville, Maryland) |
| ABSTRACT | A material, article, system and method include a probe composition that includes a hydrophobic portion, a hydrophilic portion, an analyte-binding portion and a fluorophore portion. The analyte-binding portion is configured to bind to an analyte in an aqueous solution. The fluorophore portion is configured to change an optical property of fluorescent light emitted in response to incident excitation light when the probe composition changes between a first state in which the analyte is not bound to the analyte-binding portion and a second state in which the analyte binds to the analyte-binding portion. A material includes the probe composition and a silicone hydrogel substrate having a hydrogel network that allows flow of aqueous solution through the solution and a silicone network that occupies interstices of the hydrogel network. A contact lens having the material enables remote detection of glucose concentration in tear fluid of a subject. |
| FILED | Tuesday, May 24, 2022 |
| APPL NO | 17/752733 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/1455 (20130101) A61B 5/6821 (20130101) Original (OR) Class A61B 5/14507 (20130101) A61B 5/14539 (20130101) A61B 5/14546 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/025 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) C09K 2211/1007 (20130101) C09K 2211/1011 (20130101) C09K 2211/1014 (20130101) C09K 2211/1022 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/54373 (20130101) Optical Elements, Systems, or Apparatus G02B 1/043 (20130101) Spectacles; Sunglasses or Goggles Insofar as They Have the Same Features as Spectacles; Contact Lenses G02C 7/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230025706 | McFADDEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Oncomyx Therapeutics, Inc. (Phoenix, Arizona); Arizona Board of Regents of behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Douglas Grant McFADDEN (Tempe, Arizona); Mohammed Masmudur RAHMAN (Chandler, Arizona); Nancy VILLA (Tempe, Arizona); Lino TORRES-DOMINGUEZ (Tempe, Arizona); Lina FRANCO ACHURY (Tempe, Arizona); Leslie Lynne SHARP (Rancho Santa Fe, California) |
| ABSTRACT | Disclosed herein, in certain embodiments, are recombinant myxoma viruses (MYXVs) and nucleic acid constructs encoding the recombinant MYXVs. In some embodiments, the MYXVs are engineered to inactivate or attenuate an activity or expression level of an M153 protein. In some embodiments, the MYXVs are engineered to express one or more transgenes such as a tumor necrosis factor (TNF), interleukin-12 (IL-12), or decorin. Also disclosed herein, in certain embodiments, are methods of using the MYXVs. Some embodiments include providing a MYXV as described herein to a subject in need thereof. |
| FILED | Monday, August 22, 2022 |
| APPL NO | 17/893052 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/275 (20130101) A61K 45/06 (20130101) A61K 2039/545 (20130101) A61K 2039/572 (20130101) A61K 2039/585 (20130101) A61K 2039/5154 (20130101) A61K 2039/5256 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) Peptides C07K 14/005 (20130101) Original (OR) Class C07K 14/525 (20130101) C07K 14/5434 (20130101) C07K 2319/33 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2710/24022 (20130101) C12N 2710/24033 (20130101) C12N 2710/24071 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230025707 | Luk et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kelvin C. Luk (Philadelphia, Pennsylvania); Virginia M.Y. Lee (Philadelphia, Pennsylvania); John Q. Trojanowski (Philadelphia, Pennsylvania); Kurt R. Brunden (Media, Pennsylvania); Dustin Covell (Philadelphia, Pennsylvania) |
| ABSTRACT | The present disclosure provides in one aspect monoclonal antibodies that bind α-Synuclein. In certain aspects, the antibodies preferentially bind to α-Synuclein fibrils over α-Synuclein monomer. In other aspects, the disclosure provides a method of treating, ameliorating, and/or preventing α-Synucleopathic disease in a subject, comprising administering any one of the antibodies of the disclosure to the subject. In yet other aspects, the disclosure provides methods of detecting α-Synuclein fibrils using any one of the antibodies of the disclosure. |
| FILED | Thursday, November 19, 2020 |
| APPL NO | 17/778061 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) Peptides C07K 16/18 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230025756 | Childress |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Susan Boackle Childress (Denver, Colorado) |
| ABSTRACT | The present invention contemplates that complement receptor 1 and 2 may play a role in the induction of regulatory B cells under inflammatory conditions that accompany immune-mediated diseases. For example, long noncoding RNA may regulation transcription of the complement receptor I gene, thereby resulting in an induction and/or suppression of regulatory B cells. Such long noncoding RNA in mature B cells may be specifically targeted to modify complement receptor 1 levels and induce or suppress the generation of antigen-specific regulatory B cells, thereby modifying the course of immune mediated diseases including, but not limited to, autoimmune disease, cancer, and infection. |
| FILED | Friday, February 18, 2022 |
| APPL NO | 17/675731 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class Peptides C07K 16/2803 (20130101) C07K 16/2896 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0635 (20130101) C12N 15/113 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5052 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230025770 | Lee et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | KOOKMIN UNIVERSITY INDUSTRY ACADEMY COOPERATION FOUNDATION (Seoul, South Korea) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Won Woo Lee (Incheon, South Korea); Jin Woo Yoo (Gyeonggi-do, South Korea); Yoon Suk Choi (Gyeonggi-do, South Korea); Jin Gwan Kim (Jeollanam-do, South Korea); Dong Sun Lim (Gyeonggi-do, South Korea); Hoo Kyung Lee (Seoul, South Korea) |
| ABSTRACT | An object detection method and apparatus are disclosed. The object detection method may include acquiring identification information of an object detected from each of N (N being a preset integer of 3 or more) images continuous in order of capture from the output of a classification layer of an object detection deep learning network and correcting, based on the identification information of the object detected from each of at least two images that have been captured early in order of time, among the N images, the identification information of the object detected from an image that has been captured later in order of time than the at least two images that have been captured early in order of time, among the N images. |
| FILED | Monday, March 14, 2022 |
| APPL NO | 17/694551 |
| CURRENT CPC | Image or Video Recognition or Understanding G06V 10/25 (20220101) G06V 10/764 (20220101) G06V 20/58 (20220101) Original (OR) Class G06V 2201/07 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230025922 | Garza et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Luis Garza (Baltimore, Maryland); Mohameed Islam (Baltimore, Maryland); Barbara Slusher (Baltimore, Maryland); Rana Rais (Baltimore, Maryland) |
| ABSTRACT | Methods for the use of prodrugs of itaconic acid and 1- and 4-methyl itaconic acid for inducing hair growth and treating an inflammatory, or immune activation (adaptive or innate), skin condition or other condition associated with hair loss are disclosed. |
| FILED | Thursday, October 29, 2020 |
| APPL NO | 17/772882 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/22 (20130101) A61K 31/194 (20130101) Original (OR) Class A61K 31/216 (20130101) A61K 31/225 (20130101) A61K 31/265 (20130101) A61K 31/341 (20130101) A61K 31/621 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230025932 | Canney et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Temple University-Of The Commonwealth System of Higher Education (Philadelphia, Pennsylvania); Praeventix, LLC (Exton, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel J. Canney (Ambler, Pennsylvania); Benjamin Blass Blass (Eagleville, Pennsylvania); Kevin M. Blattner (Folsom, Pennsylvania); Douglas A. Pippin (Chester Springs, Pennsylvania) |
| ABSTRACT | Described herein are new, selective modulators of the 5-HT7receptor. These selective compounds can be useful for the treatment of CNS and non-CNS indications. Compounds described herein can be selective in targeting 5-HT7 receptors as compared to other receptors and/or by selective targeting 5-HT7 receptors expressed in certain tissues or organs, thereby effective selectivity through a particular partitioning profile of the 5-HT7 modulator |
| FILED | Thursday, November 12, 2020 |
| APPL NO | 17/776531 |
| CURRENT CPC | Heterocyclic Compounds C07D 405/06 (20130101) C07D 491/107 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230026115 | Dupont |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Children`s Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pierre Dupont (Wellesley, Massachusetts) |
| ABSTRACT | A device for performing surgical procedures, such as intracardiac procedures or neurosurgical procedures, includes a solid optical window formed of a transparent, compliant material, wherein the solid optical window includes a proximal side and a distal side, wherein a distal face of the solid optical window is configured to approach tissue during a surgical procedure; an imaging system embedded into the solid optical window and positioned to obtain an image through at least a portion of the distal face of the solid optical window; and a tool channel formed through the solid optical window from the proximal side to the distal side of the solid optical window, wherein the tool channel is configured to receive a tool for performing the surgical procedure. |
| FILED | Thursday, September 29, 2022 |
| APPL NO | 17/956162 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/05 (20130101) A61B 1/015 (20130101) A61B 1/018 (20130101) Original (OR) Class A61B 1/00087 (20130101) A61B 1/00089 (20130101) A61B 1/00096 (20130101) A61B 1/00179 (20130101) A61B 10/02 (20130101) A61B 10/04 (20130101) A61B 10/0283 (20130101) A61B 17/00234 (20130101) A61B 2017/00243 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230026180 | Yoseph et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Rami Yoseph (Gaithersburg, Maryland); Yong-Chen Lu (Little Rock, Arkansas); Gal Cafri (Kibbutz Nir David, Israel); Steven A. Rosenberg (Potomac, Maryland) |
| ABSTRACT | Disclosed is an isolated or purified T cell receptor (TCR), wherein the TCR has antigenic specificity for a mutated RAS amino acid sequence presented by a human leukocyte antigen (HLA) Class I molecule. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal. |
| FILED | Monday, September 12, 2022 |
| APPL NO | 17/931391 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/7051 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230026247 | Vunjak-Novakovic et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| INVENTOR(S) | Gordana Vunjak-Novakovic (New York, New York); Warren Grayson (Baltimore, Maryland); Keith Yeager (Springfield, New Jersey) |
| ABSTRACT | An anatomically-shaped, human bone graft may be cultivated ex vivo using a bioreactor capable of perfusing large complex porous scaffolds. Scaffolds derived from image-based modeling of a target are seeded with human mesenchymal stem cells and cultivated. A bioreactor configured to house complex three-dimensional scaffold geometries provides controlled flow for perfusion of the cells. Dense uniform cellular growth can be attained throughout the entire scaffold as a result of the medium perfusion. In an embodiment, the bioreactor has a mold into which perfusion medium is pumped under pressure and multiple ports through which the medium exits the mold. |
| FILED | Thursday, August 18, 2022 |
| APPL NO | 17/890322 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/28 (20130101) Original (OR) Class A61F 2/3099 (20130101) A61F 2/30942 (20130101) A61F 2002/30957 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) C12M 25/14 (20130101) C12M 29/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230026378 | Auguste et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Debra Auguste (Briarcliff Manor, New York); Danielle Large (Boston, Massachusetts) |
| ABSTRACT | Described herein are ultra-deformable liposomes comprising a first lipid and second lipid. The first lipid comprises a first hydrophilic head linked to a first aliphatic tail, and the second lipid comprises a second hydrophilic head linked to a second aliphatic tail having at least two carbons less than the first aliphatic tail. The ultra-deformable liposomes described herein are useful, for example, as drug delivery vehicles. Accordingly, also described herein are compositions comprising an ultra-deformable liposome and a cargo, such as a drug, as well as methods for delivering a drug, such as an anti-cancer therapeutic, to a tumor. |
| FILED | Wednesday, July 13, 2022 |
| APPL NO | 17/864077 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1273 (20130101) Original (OR) Class A61K 47/6911 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230026466 | Lee et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Taekyu Lee (Brentwood, Tennessee); Kevin B. Teuscher (Nashville, Tennessee); Jianhua Tian (Montgomery Village, Maryland); Kenneth M. Meyers (Nashville, Tennessee); Somenath Chowdhury (Nashville, Tennessee); Stephen W. Fesik (Nashville, Tennessee) |
| ABSTRACT | Isoquinolmone compounds and derivatives inhibit WDR5 and associated protein-protein interactions, and the compounds and their pharmaceutical compositions are useful for treating disorders and conditions in a subject, such as cancer cell proliferation. |
| FILED | Sunday, November 08, 2020 |
| APPL NO | 17/775174 |
| CURRENT CPC | Heterocyclic Compounds C07D 401/14 (20130101) Original (OR) Class C07D 405/14 (20130101) C07D 413/14 (20130101) C07D 471/04 (20130101) C07D 487/04 (20130101) C07D 491/048 (20130101) C07D 498/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230026627 | Lynn et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Vaccitech North America, Inc. (Baltimore, Maryland); Institute of Macromolecular Chemistry (Prague 6, Czech Republic); The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| ASSIGNEE(S) | Vaccitech North America, Inc. (Baltimore, Maryland); Institute of Macromolecular Chemistry (Prague 6, Czech Republic); The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| INVENTOR(S) | Geoffrey Lynn (Baltimore, Maryland); Yaling Zhu (Gaithersburg, Maryland); Jacob Holechek (Union Bridge, Maryland); David Wilson (Baltimore, Maryland); Joe Francica (Washington, District of Columbia); Richard Laga (Prague, Czech Republic); Gabriela Muzíková (Prague, Czech Republic) |
| ABSTRACT | A star polymer of formula O[P1]-([X]-A[P2]-[Z]-[P3])n where O is a core; A is a polymer arm attached to the core; X is a linker molecule between the core and the polymer arm; Z is a linker molecule between the end of the polymer arm and P3; P1, P2 and P3 are each independently one or more pharmaceutically active compounds that act extracellularly or intracellularly, n is an integer number; [ ] denotes that the group is optional; and at least one of P1, P2 or P3 is present. |
| FILED | Thursday, April 16, 2020 |
| APPL NO | 17/604227 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) A61K 47/641 (20170801) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 83/003 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230026666 | RAO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Catholic University of America (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Venigalla B. RAO (Washington, District of Columbia); Himanshu BATRA (Washington, District of Columbia) |
| ABSTRACT | Described is an engineered viral particle programmed with T cell targeting specificity. The viral particles comprise: at least one viral vector, such as bacteriophage T4; and at least one CD4-binding protein displayed on the surface of the viral vector. Also described is a method of reactivate latent HIV-1 and cure patient with HIV-1 infection, using such an engineered viral particle. |
| FILED | Wednesday, May 04, 2022 |
| APPL NO | 17/736181 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 7/00 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 2740/16023 (20130101) C12N 2740/16042 (20130101) C12N 2740/16122 (20130101) C12N 2740/16222 (20130101) C12N 2795/10022 (20130101) C12N 2795/10023 (20130101) C12N 2795/10042 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230026716 | Diaz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Luis Diaz (Ellicott City, Maryland); Bert Vogelstein (Baltimore, Maryland); Kenneth W. Kinzler (Frankford, Delaware); Nickolas Papadopoulos (Towson, Maryland); Dung Le (Lutherville, Maryland); Drew M. Pardoll (Brookville, Maryland); Suzanne L. Topalian (Brookeville, Maryland) |
| ABSTRACT | Blockade of immune checkpoints such as cytotoxic T-lymphocyte antigen-4 (CTLA-4) and programmed death-1 (PD-1) shows promise in patients with cancer. Inhibitory antibodies directed at these receptors have been shown to break immune tolerance and promote anti-tumor immunity. These agents work particularly well in patients with a certain category of tumor. Such tumors may be particularly susceptible to treatment because of the multitude of neoantigens which they produce. |
| FILED | Monday, September 26, 2022 |
| APPL NO | 17/952919 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Peptides C07K 16/30 (20130101) C07K 16/40 (20130101) C07K 16/2803 (20130101) Original (OR) Class C07K 16/2818 (20130101) C07K 16/2827 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) Enzymes C12Y 113/11052 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230026808 | WU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dianqing WU (New Haven, Connecticut); Qianying YUAN (Guilford, Connecticut); Wenwen TANG (North Haven, Connecticut) |
| ABSTRACT | The disclosure includes methods of preventing, ameliorating, and/or treating ischemia-reperfusion injury (IRI), including but not limited to post brain stroke, using a MAP3K2/MAP3K3 inhibitor. In another aspect, the present disclosure relates to methods of preventing, ameliorating, and/or treating a lung injury related to a coronavirus infection, acute lung injury (ALI) and/or acute respiratory distress syndrome (ARDS) using a MAP3K2/MAP3K3 inhibitor. The disclosure further comprises compositions, and kits comprising compositions useful within the disclosure. |
| FILED | Tuesday, November 17, 2020 |
| APPL NO | 17/756212 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/506 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) A61P 11/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230026843 | CHENG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Regents of The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | The Board of Regents of The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Qiang CHENG (Dallas, Texas); Tuo WEI (Dallas, Texas); Daniel J. SIEGWART (Dallas, Texas) |
| ABSTRACT | The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid. |
| FILED | Sunday, September 04, 2022 |
| APPL NO | 17/929704 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5123 (20130101) Original (OR) Class A61K 48/0033 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/111 (20130101) C12N 15/113 (20130101) C12N 2310/11 (20130101) C12N 2310/14 (20130101) C12N 2310/20 (20170501) C12N 2320/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230026855 | Cornelius et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lynn Cornelius (St. Louis, Missouri); Shadmehr Demehri (St. Louis, Missouri); Raphael Kopan (St. Louis, Missouri) |
| ABSTRACT | The present disclosure encompasses compositions and methods for the treatment of precancerous skin lesions. Compositions of the invention comprise a cytotoxic agent and a thymic stromal lymphopoietin (TSLP) inducer. |
| FILED | Friday, September 16, 2022 |
| APPL NO | 17/946905 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/59 (20130101) A61K 31/513 (20130101) A61K 31/593 (20130101) A61K 45/06 (20130101) Original (OR) Class A61K 2300/00 (20130101) Heterocyclic Compounds C07D 243/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230026861 | Turng et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lih-Sheng Turng (Madison, Wisconsin); Hao-yang Mi (Madison, Wisconsin) |
| ABSTRACT | Disclosed herein are methods for modifying a substrate having a hydrophobic surface. Also disclosed are modified hydrophobic substrates. The modified hydrophobic substrates and methods disclosed herein advantageously improve cell affinity and antithrombogenicity of hydrophobic surfaces. |
| FILED | Monday, September 26, 2022 |
| APPL NO | 17/935300 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2310/00389 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) A61L 27/54 (20130101) A61L 27/507 (20130101) Original (OR) Class A61L 33/0023 (20130101) A61L 2300/42 (20130101) Compositions of Macromolecular Compounds C08L 67/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230026961 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ge Wang (Loudonville, New York); Chuang Niu (Troy, New York); Wenxiang Cong (Albany, New York) |
| ASSIGNEE(S) | Rensselaer Polytechnic Institute (Troy, New York) |
| INVENTOR(S) | Ge Wang (Loudonville, New York); Chuang Niu (Troy, New York); Wenxiang Cong (Albany, New York) |
| ABSTRACT | In one embodiment, there is provided an apparatus for low-dimensional manifold constrained disentanglement for metal artifact reduction (MAR) in computed tomography (CT) images. The apparatus includes a patch set construction module, a manifold dimensionality module, and a training module. The patch set construction module is configured to construct a patch set based, at least in part on training data. The manifold dimensionality module is configured to determine a dimensionality of a manifold. The training module is configured to optimize a combination loss function comprising a network loss function and the manifold dimensionality. The optimizing the combination loss function includes optimizing at least one network parameter. |
| FILED | Thursday, July 07, 2022 |
| APPL NO | 17/859186 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/0454 (20130101) Image Data Processing or Generation, in General G06T 5/006 (20130101) G06T 11/008 (20130101) Original (OR) Class G06T 2207/10081 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230027198 | KHAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Rockefeller University (New York, New York); Bridge Medicines, LLC (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tanweer A. KHAN (Bridgewater, New Jersey); Nigel LIVERTON (Harleysville, Pennsylvania); Yoshiyuki FUKASE (Edgewater, New Jersey); Mayako MICHINO (New York, New York); Andrew W. STAMFORD (Chatham, New Jersey); Michael W. MILLER (Scotch Plains, New Jersey); David HUGGINS (New York, New York); Peter MEINKE (Scotch Plains, New Jersey); David C. ALLIS (New York, New York); Liling WAN (New York, New York); Tammy LADDUWAHETTY (London, United Kingdom); Joseph VACCA (Telford, Pennsylvania) |
| ABSTRACT | Methods and compositions for treating leukemia are disclosed. Acylated 6-aminoindoles, acylated 6-aminopyrrolopyridines and acylated 3-aminopyrrolo[3,2-c]pyridazines of the following formula inhibit ENL/AF9 YEATS and are therefore useful for treating leukemia. |
| FILED | Thursday, December 17, 2020 |
| APPL NO | 17/757492 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Heterocyclic Compounds C07D 471/04 (20130101) Original (OR) Class C07D 487/04 (20130101) C07D 519/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230027620 | AAKALU |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vinay Kumar AAKALU (Chicago, Illinois) |
| ABSTRACT | A synthetic peptide including the sequence SHXGY (SEQ ID NO:2) is described as are methods of using the same for promoting wound healing and epithelial cell migration. |
| FILED | Wednesday, November 25, 2020 |
| APPL NO | 17/778138 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1729 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/02 (20180101) A61P 27/02 (20180101) A61P 31/04 (20180101) Peptides C07K 14/4723 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230027709 | HERR et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (Charlottesville, Virginia) |
| ASSIGNEE(S) | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (Charlottesville, Virginia) |
| INVENTOR(S) | John C. HERR (Charlottesville, Virginia); Monika SACHDEV (Charlottesville, Virginia); Arabinda MANDAL (Charlottesville, Virginia) |
| ABSTRACT | The present invention provides compositions and methods useful for regulating fertilization and for use as a contraceptive based on the discovery herein of an oocyte specific protein, SAS1R (Sperm Acrosomal SLLP1 Receptor), which is a sperm protein receptor. Six SAS1R variants, including the full length SAS1R, were identified. mSLLP1 and SAS1R co-localized to oocytes and to acrosomes of acrosome-reacted sperm. Interactions between mSLLP1 and SAS1R were demonstrated by far-western analysis, in a yeast two-hybrid system under stringent selection conditions, and by immunoprecipitation of SAS1R by anti-mSLLP1 as well as the converse. Purified recombinant SAS1R was found to have protease activity, to inhibit fertilization in-vitro, and to induce an immune response in females. Together, the results suggest SAS1R is a proteolytically active, oocyte and early embryo specific oolemmal metalloprotease receptor for the sperm intra-acrosomal ligand SLLP1 and is a target for regulating fertilization and as a contraceptive. |
| FILED | Monday, November 16, 2020 |
| APPL NO | 17/099247 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/177 (20130101) A61K 38/1709 (20130101) A61K 38/4886 (20130101) A61K 39/0006 (20130101) Peptides C07K 16/28 (20130101) Original (OR) Class C07K 2317/76 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2333/96486 (20130101) G01N 2500/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230027723 | Shen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California); Cambridge Enterprise Limited (Cambridge, United Kingdom) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cheng Shen (Pasadena, California); Changhuei Yang (Pasadena, California); Adiyant Lamba (Cambridge, United Kingdom); Magdalena D. Zernicka-Goetz (Pasadena, California) |
| ABSTRACT | Disclosed herein include systems, devices, and methods for detecting embryo polarization from a 2D image generated from a 3D image of an embryo that is not fluorescently labeled using a convolutional neural network (CNN), e.g., deep CNN. |
| FILED | Thursday, July 07, 2022 |
| APPL NO | 17/859500 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Original (OR) Class G06N 3/0454 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/20076 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30044 (20130101) Image or Video Recognition or Understanding G06V 10/82 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230027884 | Machielse et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mandos LLC (West Hollywood, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bernardus Nicolaas Machielse (North Potomac, Maryland); Allan Darling (North Potomac, Maryland) |
| ABSTRACT | This disclosure provides mixtures of beta-cyclodextrin molecules substituted at one or more hydroxyl positions by hydroxypropyl groups, the mixture optionally including unsubstituted beta-cyclodextrin molecules, for use as a pharmaceutically active ingredient; methods of making such mixtures; methods of qualifying such mixtures for use in a pharmaceutical composition suitable for intrathecal or intracerebroventricular administration; pharmaceutical compositions suitable for intrathecal or intracerebroventricular administration comprising such mixtures; and methods of using the pharmaceutical compositions for treatment of Niemann-Pick disease Type C. |
| FILED | Friday, September 16, 2022 |
| APPL NO | 17/946670 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/08 (20130101) A61K 9/0019 (20130101) A61K 9/0085 (20130101) A61K 31/724 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230027885 | Rogers |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | Yale University (New Haven, Connecticut) |
| INVENTOR(S) | Faye A. Rogers (Norwalk, Connecticut) |
| ABSTRACT | Disclosed herein are methods and agents for the treatment of cancer using p53-independent apoptosis to reduce the number of p53-depleted or p53-mutated cancer cells that have amplified HER2 gene. Also disclosed herein are methods and agents for the treatment of HJ-R2-positive: cancer in individuals with Li-Fraumeni Syndrome. |
| FILED | Monday, June 27, 2022 |
| APPL NO | 17/850793 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/543 (20170801) A61K 47/6807 (20170801) Peptides C07K 16/3015 (20130101) Original (OR) Class C07K 2317/73 (20130101) C07K 2317/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2310/15 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230027906 | Balaj et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Leonora Balaj (Lincoln, Massachusetts); Koushik Muralidharan (Boston, Massachusetts); Anudeep Yekula (Boston, Massachusetts); Bob S. Carter (Boston, Massachusetts) |
| ABSTRACT | Aspects of the present disclosure relate to methods for detecting mutant TERT promoter sequences (e.g., C228T, C250T) that provide several improvements over conventional detection methods, thereby enabling detection of such mutations in biological fluid samples (e.g., plasma), which contain miniscule amounts of nucleic acids. Such improvements include, but are not limited to, improvements in detection sensitivity and specificity, which allows detection of mutations in a biological sample having a low level of nucleic acids such as a plasma sample from a patient having brain cancer (e.g., glioma). |
| FILED | Monday, December 07, 2020 |
| APPL NO | 17/781423 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6858 (20130101) C12Q 1/6886 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230027965 | Chan-Hui et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THERACLONE SCIENCES, INC. (Seattle, Washington); THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California); INTERNATIONAL AIDS VACCINE INITIATIVE (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Po-Ying Chan-Hui (Bellevue, Washington); Katherine Doores (San Diego, California); Michael Huber (Zurich, Switzerland); Stephen Kaminsky (Bronx, New York); Steven Frey (Redmond, Washington); Ole Olsen (Everett, Washington); Jennifer Mitcham (Redmond, Washington); Matthew Moyle (Redmond, Washington); Sanjay K. Phogat (Frederick, Maryland); Dennis R. Burton (La Jolla, California); Laura Majorie Walker (San Diego, California); Pascal Raymond Georges Poignard (San Diego, California); Wayne Koff (Stony Brook, New York); Melissa Danielle De Jean De St. Marcel Simek-Lemos (Brooklyn, New York) |
| ABSTRACT | The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided. |
| FILED | Thursday, July 15, 2021 |
| APPL NO | 17/376276 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/21 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Peptides C07K 16/1045 (20130101) C07K 16/1063 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230028081 | ABIDIAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Houston System (Houston, Texas) |
| ASSIGNEE(S) | University of Houston System (Houston, Texas) |
| INVENTOR(S) | Mohammad Reza ABIDIAN (Houston, Texas); Mohammadjavad ESLAMIAN (Houston, Texas); Sheereen MAJD (Houston, Texas) |
| ABSTRACT | In one aspect, the present disclosure provides organic semiconductors (OSNTs) as well as high-performance electrochemical devices based on the present OSNTs for the production of micro and nano-scale actuators. The present OSNTs may be used in several applications, including movable and implantable interface devices, such as flexible neural microelectrodes. Also provided herein are flexible neural microelectrodes based on conjugated polymer actuators |
| FILED | Friday, July 15, 2022 |
| APPL NO | 17/812932 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/27 (20210101) A61B 2562/125 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 15/00 (20130101) B82Y 30/00 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/004 (20130101) Original (OR) Class H01L 51/0035 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230028293 | Sherbenou et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Daniel Sherbenou (Denver, Colorado); Zachary Walker (Aurora, Colorado); Beau Idler (Parker, Colorado); The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Sherbenou (Denver, Colorado); Zachary Walker (Aurora, Colorado); Beau Idler (Parker, Colorado) |
| ABSTRACT | Multiple myeloma (MM) combination therapies based on protein translation inhibitors, immunomodulators, and bromodomain extra-terminal inhibitors. Methods are provided for treating multiple myeloma in a subject, including administering a therapeutically effective amount of at least one protein translation inhibitor and a therapeutically effective amount of at least one immunomodulatory drug (IMiD), administering a therapeutically effective amount of at least one protein translation inhibitor and a therapeutically effective amount of at least one BET inhibitor, and/or administering a therapeutically effective amount of at least one IMiD and a therapeutically effective amount of at least one BET inhibitor. |
| FILED | Tuesday, December 08, 2020 |
| APPL NO | 17/778347 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/55 (20130101) A61K 31/69 (20130101) A61K 31/454 (20130101) A61K 31/566 (20130101) Original (OR) Class A61K 31/573 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230028516 | Slusher et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland); INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY AS CR V.V.I. (Prague, Czech Republic) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Barbara Slusher (Baltimore, Maryland); Mohameed Islam (Baltimore, Maryland); Rana Rais (Baltimore, Maryland); Luis Garza (Baltimore, Maryland); Benjamin Bell (Baltimore, Maryland); Pavel Majer (Kretin, Czech Republic); Lukas Tenora (Prague, Czech Republic); Ivan Snajdr (Prague, Czech Republic); Marcela Krecmerova (Prague, Czech Republic) |
| ABSTRACT | Prodrugs of itaconic acid and 1- and 4-methyl itaconic acid and their use for treating a disease, disorder, or condition associated with inflammation are disclosed. |
| FILED | Thursday, October 29, 2020 |
| APPL NO | 17/772879 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 69/90 (20130101) C07C 69/593 (20130101) Original (OR) Class C07C 229/36 (20130101) C07C 237/12 (20130101) C07C 271/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230028927 | Pasqualini et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Renata Pasqualini (New Brunswick, New Jersey); Wadih Arap (New Brunswick, New Jersey); Fernanda Iamassaki Staquicini (New Brunswick, New Jersey); Fortunato Ferrara (Santa Fe, New Mexico); Sara D'Angelo (Santa Fe, New Mexico); Andrew R.M. Bradbury (Santa Fe, New Mexico) |
| ABSTRACT | Isolated or recombinant EphA5 or GRP78 targeting antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer. A method of rapidly identifying antibodies or antibody fragments for the treatment of cancer using a combination of in vitro and in vivo methodologies is also provided. |
| FILED | Friday, June 10, 2022 |
| APPL NO | 17/837943 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/07 (20130101) A61K 39/3955 (20130101) A61K 39/39558 (20130101) A61K 47/6803 (20170801) A61K 47/6817 (20170801) A61K 47/6843 (20170801) A61K 47/6849 (20170801) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/18 (20130101) C07K 16/28 (20130101) C07K 16/30 (20130101) Original (OR) Class C07K 16/3023 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1037 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57423 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230028963 | Coakley et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Oregon Health and Science University (Portland, Oregon) |
| ASSIGNEE(S) | Oregon Health and Science University (Portland, Oregon) |
| INVENTOR(S) | Fergus Coakley (Portland, Oregon); Stevan Wittenbrock (Portland, Oregon); Forrest Seitz (Portland, Oregon); Christopher J. Jensen (Portland, Oregon); Daniel R. Baker (Portland, Oregon) |
| ABSTRACT | An anatomical sensing system-guided prostate procedure device that includes a housing having a proximal end and a distal end. The housing may be divided into a distal housing section, amid housing section, and a proximal housing section, wherein the distal housing section is configured for insertion into the anus and retention in the rectum of a subject. The device further includes an instrument convergence point disposed between the proximal end and the distal end, the convergence point configured to allow an instrument pass though the instrument convergence point at a variable angle; and an instrument angle orienting system at the proximal end of the housing, the angle orienting system directing an orientation of the variable angle about the convergence point. Methods of the using an anatomical sensing system-guided prostate procedure device and system including the same. |
| FILED | Wednesday, October 05, 2022 |
| APPL NO | 17/960636 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 10/04 (20130101) A61B 10/0241 (20130101) A61B 34/20 (20160201) Original (OR) Class A61B 2034/2051 (20160201) A61B 2090/3983 (20160201) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/285 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230029057 | Lin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Tzu-Hsiang Lin (Miami, Florida); Zachary Danziger (Miami, Florida) |
| ASSIGNEE(S) | The Florida International University Board of Trustees (Miami, Florida) |
| INVENTOR(S) | Tzu-Hsiang Lin (Miami, Florida); Zachary Danziger (Miami, Florida) |
| ABSTRACT | Systems, methods, and protocols for developing invasive brain computer interface (iBCI) decoders non-invasively by using emulated brain data are provided. A human operator can interact in real-time with control algorithms designed for iBCI. An operator can provide input to one or more computer models (e.g., via body gestures), and this process can generate emulated brain signals that would otherwise require invasive brain electrodes to obtain. |
| FILED | Monday, July 11, 2022 |
| APPL NO | 17/811648 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/014 (20130101) G06F 3/015 (20130101) Original (OR) Class G06F 3/017 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230029085 | Eavarone et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Seagen Inc. (Bothell, Washington); The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | Seagen Inc. (Bothell, Washington); The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | David A. Eavarone (North Quincy, Massachusetts); Jeffrey Behrens (Newton, Massachusetts); Jillian M. Prendergast (Maynard, Massachusetts); Bo R. Rueda (Windham, New Hampshire); Rosemary Foster (Arlington, Massachusetts); Kristen D. Starbuck (Amherst, New York) |
| ABSTRACT | Compositions and methods for treating ovarian cancer are provided. Methods include combined treatment with chemotherapeutic agents and anti-STn antibodies. Chemotherapy resistant ovarian cancer cells may be reduced. Chemotherapy resistant ovarian cancer cells may include cancer stem cells. |
| FILED | Wednesday, March 16, 2022 |
| APPL NO | 17/696190 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/00 (20130101) A61K 31/337 (20130101) A61K 31/555 (20130101) A61K 33/242 (20190101) A61K 33/243 (20190101) A61K 33/244 (20190101) A61K 39/39558 (20130101) A61K 47/6803 (20170801) A61K 47/6851 (20170801) A61K 47/6869 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/44 (20130101) Original (OR) Class C07K 2317/73 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57449 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230029153 | WYNNE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | WYNNVISION, LLC (Richmond, Virginia) |
| ASSIGNEE(S) | WynnVision, LLC (Richmond, Virginia) |
| INVENTOR(S) | Kenneth J. WYNNE (Midlothian, Virginia); Olga ZOLOTARSKAYA (Richmond, Virginia); Rebecca JARRELL (Williamsburg, Virginia); Kennard BRUNSON (Richmond, Virginia); Chenyu WANG (Midlothian, Virginia) |
| ABSTRACT | A composition, comprising: a physiologically-acceptable polydimethylsiloxane having a surface; and one or more normal C6-C20NR1R2 saturated amine, salt thereof, or combination thereof, in contact with the polydimethylsiloxane, the surface, or both, wherein R1 and R2 may be same or different and independently selected from H, —CH3, —CH2CH3, —CH2CH2CH3, or combination thereof. |
| FILED | Monday, July 18, 2022 |
| APPL NO | 17/867252 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 29/06 (20130101) Original (OR) Class A61L 29/085 (20130101) A61L 31/06 (20130101) A61L 2300/404 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230029216 | ZWICKER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Jeffrey I. ZWICKER (Boston, Massachusetts); Bruce FURIE (Boston, Massachusetts); Robert FLAUMENHAFT (Boston, Massachusetts) |
| ABSTRACT | Disclosed are compositions and methods for treating sickle cell disease. Also disclosed are methods of treating sickle cell disease comprising administering to a subject in need thereof an effective amount of isoquercetin, vitamin B3, vitamin C, and optionally folic acid and wherein the effective amount is sufficient to halt progression of one or more of the symptoms of sickle cell disease. |
| FILED | Friday, July 15, 2022 |
| APPL NO | 17/865609 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/352 (20130101) Original (OR) Class A61K 31/375 (20130101) A61K 31/455 (20130101) A61K 31/519 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230029257 | KISHI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Jocelyn KISHI (Boston, Massachusetts); Ninning LIU (Boston, Massachusetts); Sinem SAKA (Allston, Massachusetts); Peng YIN (Brookline, Massachusetts); Kuanwei SHENG (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein are compositions, kits, and methods for nucleic acid barcoding. The barcode compositions provided herein can be used to linearly, combinatorially, or spatially barcode a plurality of targets in a sample. Also provided herein is a device for use in a barcoding method provided herein comprising a light source and a sample holder. |
| FILED | Friday, December 11, 2020 |
| APPL NO | 17/783750 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6818 (20130101) Original (OR) Class C12Q 1/6841 (20130101) C12Q 2600/16 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230029307 | FERRARA |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Napoleone FERRARA (San Diego, California) |
| ABSTRACT | Compositions and methods for treating a VEGF-related ophthalmic disorder in a subject in need comprising, administering intravitreally to the subject a therapeutically effective amount of an anti-VEGF agent, comprising a VEGF binding portion operatively linked to a Fc-IgG, wherein the VEGF binding portion comprises at least one VEGF binding domain that is an IgG-like domain 2 of VEGFR-1. |
| FILED | Wednesday, June 01, 2022 |
| APPL NO | 17/830298 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0048 (20130101) A61K 38/179 (20130101) Original (OR) Class A61K 39/001109 (20180801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) Peptides C07K 14/71 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230029362 | Iwasaki |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Akiko Iwasaki (New Haven, Connecticut) |
| ABSTRACT | The present disclosure relates to compositions and methods for treating or preventing a disease or disorder of the brain, spinal cord or central nervous system. It is described herein that an immunogenic composition which induces a CD4 T cell immune response induces permeability of the blood brain barrier, and allows for the access of a therapeutic antibody or agent to the brain, spinal cord or central nervous system. |
| FILED | Friday, December 04, 2020 |
| APPL NO | 17/782338 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/001114 (20180801) Original (OR) Class A61K 39/39558 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/1018 (20130101) C07K 2317/76 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20230021549 | LIM et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Soon Wei Daniel LIM (Cambridge, Massachusetts); Joon-Suh PARK (Cambridge, Massachusetts); Maryna Leonidivna MERETSKA (Cambridge, Massachusetts); Federico CAPASSO (Cambridge, Massachusetts); Ahmed Hassen Dorrah (Cambridge, Massachusetts) |
| ABSTRACT | Disclosed is a method of generating a functional singularity at a point or collection of points. The method may include determining a relationship between one or more parameters associated with a physical structure and a spatial gradient of field values of at least one of electromagnetic energy, sound energy, particle beam, or water waves manipulated by the physical structure, configuring, according to the relationship, the spatial gradient of field values to represent a functional singularity at a point, performing backpropagation using the spatial gradient of field values to obtain design parameters corresponding to values for the one or more parameters that achieve the functional singularity at the point, and producing a physical structure having the design parameters. |
| FILED | Wednesday, January 19, 2022 |
| APPL NO | 17/579460 |
| CURRENT CPC | Electric Digital Data Processing G06F 17/16 (20130101) G06F 17/148 (20130101) Original (OR) Class G06F 17/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230021860 | Sobinov et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | West Virginia University (Morgantown, West Virginia); University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anton Sobinov (Morgantown, West Virginia); Sergiy Yakovenko (Morgantown, West Virginia); Valeriya Gritsenko (Morgantown, West Virginia); Matthew Boots (Morgantown, West Virginia); Robert Gaunt (Pittsburgh, Pennsylvania); Jennifer Collinger (Pittsburgh, Pennsylvania); Lee Fisher (Pittsburgh, Pennsylvania) |
| ABSTRACT | A system and method for controlling a device, such as a virtual reality (VR) and/or a prosthetic limb are provided. A biomimetic controller of the system comprises a signal processor and a musculoskeletal model. The signal processor processes M biological signals received from a residual limb to transform the M biological signals into N activation signals, where M and N are integers and M is less than N. The musculoskeletal model transforms the N activation signals into intended motion signals. A prosthesis controller transforms the intended motion signals into three or more control signals that are outputted from an output port of the prosthesis controller. A controlled device receives the control signals and performs one or more tasks in accordance with the control signals. |
| FILED | Saturday, December 19, 2020 |
| APPL NO | 17/787701 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/70 (20130101) A61F 2/72 (20130101) Original (OR) Class A61F 2/582 (20130101) A61F 2002/6827 (20130101) Electric Digital Data Processing G06F 3/011 (20130101) G06F 3/015 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230021871 | KUZNIA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ULTRA COMMUNICATIONS, INC. (Vista, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles B. KUZNIA (ENCINITAS, California); Joseph Farzin AHADIAN (SAN MARCOS, California); Sandra SKENDZIC (VISTA, California); Vernon Eugene SHRAUGER (CAMBRIDGE, Massachusetts) |
| ABSTRACT | Methods and devices for a planar bidirectional optical coupler for wavelength division multiplexing are described. The optical coupler can be used in an optical transceiver housed within a compact optical interconnect module for optical fiber-based data communication and/or OTDR measurement. According to one aspect, the optical coupler includes a layered planar construction, each layer based on a transparent planar substrate. A bottom carrier layer includes a metallized surface for mounting of electronic and/or electro-optical components. A lens layer overlays the carrier layer and includes collimating transmit and/or focusing receive lenses. A beam splitter/combiner layer overlays the lens layer and includes angled coated lateral surfaces that provide beam splitting and wavelength filtering functionality. The beam splitter/combiner layer is optically coupled to a ferrule receptacle of a fiber connector of the optical transceiver. Alternatively, the beam splitter/combiner is optically coupled to a planar optical fiber connector via an additional lens guide layer. |
| FILED | Friday, July 15, 2022 |
| APPL NO | 17/812967 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/4246 (20130101) Original (OR) Class Transmission H04B 10/071 (20130101) Multiplex Communication H04J 14/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230021979 | Coppock |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | U.S. Army DEVCOM, Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew B. Coppock (Arlington, Virginia) |
| ABSTRACT | A method for developing capture agents for target proteins employs a compound library to find cyclic peptide sequences that bind the target protein. The target protein is also reacted with a clickable group-provider reagent to provide the protein with clickable groups. The compounds in the library are provided with complementary clickable groups that bind the clickable group on the target protein when the peptide sequences bind the target protein. In some embodiments, the cyclic peptide sequences that bind the target protein are incorporated into constructs having one or more arms that can serve as capture agents or potential treatments against the pathogens from which the target protein is derived. Some embodiments provide pharmaceutical compositions for immunoassays, diagnostics, therapeutics or the like, that employ the constructs. |
| FILED | Tuesday, April 19, 2022 |
| APPL NO | 17/723553 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Original (OR) Class C12N 15/1072 (20130101) C12N 15/1086 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 40/02 (20130101) C40B 40/10 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/543 (20130101) G01N 33/5008 (20130101) G01N 33/6845 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230021998 | Nieto et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andy Nieto (Morgan Hill, California); Anthony Michael DeMartino (Glendale, Arizona) |
| ABSTRACT | This disclosure, and the exemplary embodiments provided herein, include 3D printed titanium composites and methods including 1 vol. % carbon nanotube reinforcements on selective laser melt printed Ti64. The interrelationships with laser energy density, laser power, and laser scan speed are demonstrated and discussed. Utilizing selective laser melting, according to one exemplary embodiment of this disclosure, a >99% dense Ti-CNT composite is disclosed with microhardness of 4.75 GPa—a 30% enhancement over its Ti64 counterpart. |
| FILED | Monday, July 11, 2022 |
| APPL NO | 17/862166 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 9/04 (20130101) B22F 10/28 (20210101) Original (OR) Class B22F 2009/043 (20130101) B22F 2301/205 (20130101) B22F 2302/403 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230022311 | SANJANA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NEW YORK GENOME CENTER, INC (New York, New York); NEW YORK UNIVERSITY (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Neville E. SANJANA (New York, New York); Hans-Hermann WESSELS (Brooklyn, New York); Alejandro MENDEZ-MANCILLA (New York, New York) |
| ABSTRACT | A Class 2, Type VI clustered regularly interspaced short palindromic repeat (CRISPR) RNA (crRNA) which comprises a direct repeat (DR) stem loop sequence and a guide or spacer sequence, is provided characterized by a DR selected from those of Table 9. Also described is are methods for generating, selecting, characterizing and optimizing a clustered regularly interspaced short palindromic repeats (CRISPR) RNA (crRNA) for use in the CRISPR-Cas13d system described herein. Also provided is a screening method to identify crRNA particularly suited for use with specified targets. Further, the invention includes non-naturally occurring, synthesized or engineered crRNAs as described herein along with nucleic acid molecule, vectors, RNPs, cells, libraries, and compositions comprising the same, and uses thereof in treating a disease or in functionally screening a gene. A method for blocking an RNA target without degradation and a method for modification of multiple RNA targets using the same CRISPR effector protein are also disclosed. |
| FILED | Wednesday, November 25, 2020 |
| APPL NO | 17/756459 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2320/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230022693 | Facchetti et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois); Flexterra, Inc. (Skokie, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Antonio F. Facchetti (Chicago, Illinois); Tobin J. Marks (Evanston, Illinois); Wei Huang (Deyang, China PRC); Jianhua Chen (Shenzhen, China PRC); Yu Xia (Northbrook, Illinois) |
| ABSTRACT | Photocurable compositions that combine redox-active semiconducting organic polymers with photocurable organic molecules are provided. Upon exposure to radiation, the photocurable compositions form ion-permeable, electrically conductive crosslinked organic films that can be used as conducting channels in n-channel or p-channel organic electrochemical transistors, including vertical organic electrochemical transistors (vOECTs). The vOECTs can be incorporated in complementary electronic circuits. |
| FILED | Tuesday, July 05, 2022 |
| APPL NO | 17/857596 |
| CURRENT CPC | Compositions of Macromolecular Compounds C08L 65/00 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/24 (20130101) C09D 165/00 (20130101) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 9/22 (20130101) H01G 9/26 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/283 (20130101) H01L 51/0036 (20130101) Original (OR) Class H01L 51/0043 (20130101) H01L 51/0566 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230022751 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Palo Alto Research Center Incorporated (Palo Alto, California) |
| ASSIGNEE(S) | Palo Alto Research Center Incorporated (Palo Alto, California) |
| INVENTOR(S) | Randi Wang (Mountain View, California); Saman Mostafavi (San Francisco, California); Morad Behandish (San Mateo, California) |
| ABSTRACT | Methods and systems for modeling physical systems may use a hybrid approach for surrogate modeling that incorporates both modeling based on physical principles and fitting to data. For example, a method for developing a reduced-order models (ROM) of a physical system may comprise: defining a quantity of interest (QoI) for the physical system; defining a lumped-parameter surrogate (LPS) of the physical system based on physical principles; deriving a topology from the LPS; deriving a governing equation of the ROM from the topology, wherein the governing equation has unknown parameters; collecting data about the QoI of the physical system; and fitting the governing equation based on the data to derive values for the unknown parameters and yield the ROM, wherein the ROM approximates the QoI. |
| FILED | Thursday, July 22, 2021 |
| APPL NO | 17/382834 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/20 (20200101) Original (OR) Class G06F 2111/10 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230022775 | Soenksen Martinez et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Luis Ruben Soenksen Martinez (Boston, Massachusetts); Nicolaas Angenent-Mari (Somerville, Massachusetts); Alexander S. Garruss (Cambridge, Massachusetts); James J. Collins (Newton, Massachusetts); George M. Church (Cambridge, Massachusetts); Katherine Collins (Cambridge, Massachusetts); Diogo M. Camacho (Cambridge, Massachusetts) |
| ABSTRACT | This disclosure provides riboregulators specific for particular viruses or for particular human transcription factors. The viral-specific riboregulators may be used to detect the presence of the particular virus, and this may enable diagnosis of an infection. The transcription factor specific riboregulators may be used to detect the presence and/or measure the level of the particular transcription factor, and this may enable diagnosis or prognosis of a particular condition such as cancer. |
| FILED | Friday, December 11, 2020 |
| APPL NO | 17/784899 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1089 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/701 (20130101) C12Q 1/6816 (20130101) Original (OR) Class C12Q 1/6886 (20130101) C12Q 1/6897 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230023197 | CHON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF CONNECTICUT (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | KI H. CHON (Mansfield, Connecticut); HUGO POSADA-QUINTERO (Vernon, Connecticut) |
| ABSTRACT | Methods, systems and apparatuses for determining oxygen toxicity in users is disclosed. Electrodermal activity (EDA) data from a sensor may be received. The EDA data may be indicative of one or more physiological signals derived from sweat gland activity of the user. Time-varying index values may be determined based on the EDA data. The time-varying index values may be compared to a threshold to determine if one or more of the values satisfies the threshold. Satisfying the threshold may indicate oxygen toxicity is occurring within the user. A notification may be caused to occur based on the time-varying index value satisfying the threshold. The notification may cause the user to take actions to reduce the potential for further oxygen toxicity. |
| FILED | Thursday, July 14, 2022 |
| APPL NO | 17/865105 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0531 (20130101) A61B 5/721 (20130101) A61B 5/742 (20130101) A61B 5/4266 (20130101) A61B 5/7228 (20130101) A61B 5/7267 (20130101) Original (OR) Class A61B 5/7282 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230023286 | Evans |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Carillon Technologies Management Corporation (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John David Evans (Arlington, Virginia) |
| ABSTRACT | A watercraft comprises a vehicle payload bay; a sail connected to the payload bay for propelling the watercraft in a foiling mode; and three or more hydrofoils connected to the payload bay. The hydrofoils are configured to provide control of the roll, pitch, and yaw of the watercraft and to elevate the vehicle payload by above a water surface when the watercraft is in the foiling mode. The hydrofoils can also provide control of roll, pitch, yaw, and elevation of the watercraft during the transition from a prone mode to a foiling mode. A mechanical propulsive system can be used for propelling the watercraft at least during transition from the prone mode to the foiling mode. The watercraft may not include a hull such that during the transition from the prone mode to the foiling mode, pitch and roll control are not substantially provided through the actions of gravity and buoyancy. |
| FILED | Monday, December 21, 2020 |
| APPL NO | 17/786261 |
| CURRENT CPC | Ships or Other Waterborne Vessels; Equipment for Shipping B63B 1/26 (20130101) Original (OR) Class B63B 1/30 (20130101) B63B 2007/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20230023483 — METHODS AND APPARATUS TO ENABLE CUSTOMIZATION OF PIGTAIL LENGTHS OF OPTICAL CONNECTORS
| US 20230023483 | Morgan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wesley Morgan (Lake Oswego, Oregon); Feifei Cheng (Chandler, Arizona); Divya Pratap (Hillsboro, Oregon) |
| ABSTRACT | Methods, apparatus, systems, and articles of manufacture are disclosed to enable customization of pigtail lengths of optical connectors. Disclosed is an apparatus comprising an affixed fiber array unit plug including a first optical fiber, a detachable fiber array unit plug including a second optical fiber, the detachable fiber array unit plug to be removably coupled to the affixed fiber array unit plug, and guide pins to interface with both the detachable fiber array unit plug and the affixed fiber array unit plug when coupled together, the guide pins to facilitate alignment of the first optical fiber with the second optical fiber. |
| FILED | Tuesday, September 27, 2022 |
| APPL NO | 17/954172 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/3825 (20130101) Original (OR) Class G02B 6/3831 (20130101) G02B 6/3839 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20230024072 — Millimeter-Scale Chip-Based Supercontinuum Generation For Optical Coherence Tomography
| US 20230024072 | Ji et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xingchen Ji (New York, New York); Michal Lipson (New York, New York); Diana Mojahed (New York, New York); Yoshitomo Okawachi (River Edge, New Jersey); Christine P Hendon (Bronx, New York); Alexander L Gaeta (New York, New York) |
| ABSTRACT | Methods, systems, and devices are described for generating an optical signal. An example device may comprise a chip and a waveguide disposed on the chip and comprising silicon nitride. The waveguide may be configured to generate, based on nonlinear effects applied to a pump signal from a pump laser, an optical signal having a broader spectrum than the pump signal. The waveguide may have a width and a height such that the optical signal has near zero group-velocity-dispersion. |
| FILED | Wednesday, July 13, 2022 |
| APPL NO | 17/812196 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0066 (20130101) Optical Elements, Systems, or Apparatus G02B 6/1225 (20130101) G02B 2006/12061 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/365 (20130101) G02F 1/3528 (20210101) Original (OR) Class Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/0092 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230024217 | Dou et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Letian Dou (West Lafayette, Indiana); Blake Peter Finkenauer (West Lafayette, Indiana) |
| ABSTRACT | A perovskite-polymer composite comprising a perovskite and a polymer, wherein the polymer has a structural unit comprising a thiourea (—HN(C═S)NH—) fragment and a (—R1—O—R2—) fragment, wherein R1 and R2 are each independently a C1-C6 alkyl or a cycloalkyl linker; a mechanically robust and self-healable solar cell comprising same; and a method of making same. |
| FILED | Thursday, April 14, 2022 |
| APPL NO | 17/720348 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0034 (20130101) Original (OR) Class H01L 51/0094 (20130101) H01L 51/4213 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230025033 | Black |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Naval Medical Research Center (Silver Spring, Maryland) |
| ASSIGNEE(S) | United States of American as Represented by the Secretary of the Navy (Silver Spring, Maryland) |
| INVENTOR(S) | Evan Black (Antioch, Illinois) |
| ABSTRACT | A dental implant identification system is provided that aids a dental professional in identifying the type of dental implant that has been surgically placed into maid lary or mandibular bone of a patient who requires restorative dental procedures. Additionally, a dental implant identification system is provided. that aids a dental professional in identifying the forensic remains of victims due to various factors and circumstances. |
| FILED | Monday, July 25, 2022 |
| APPL NO | 17/872337 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 90/90 (20160201) Dentistry; Apparatus or Methods for Oral or Dental Hygiene A61C 8/005 (20130101) Original (OR) Class A61C 8/0075 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230025482 | Hetrick et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin Hetrick (Dallas, Texas); Matthew Bangerter (Dallas, Texas); Christopher K. Solecki (McKinney, Texas); Zachary Scott Zutavern (Dallas, Texas); Scott E. Herrmann (Dallas, Texas) |
| ABSTRACT | An aft pivot assembly includes a height adjustment mechanism integrated into a device for mounting a payload, to enable release of the payload. The aft pivot assembly releasably secures an aft portion of the payload, such a pod, store, ordinance, or fuel tank. The aft pivot assembly includes a shaft operable with the mount device and a release component, the shaft being rotatable about multiple shaft axes relative to the mount device so as to either minimize or eliminate carriage loads about the aft portion, while reacting jettison loads during a jettison event or phase. The rotation of the shaft about its shaft axes can further be limited via a limit device. As the payload transitions from a carriage phase to a jettison phase, the shaft moves in multiple degrees of freedom and in multiple axes relative to the mount device. |
| FILED | Friday, April 29, 2022 |
| APPL NO | 17/732817 |
| CURRENT CPC | Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 1/02 (20130101) Original (OR) Class B64D 37/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230025651 | Leo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sin Yen Leo (Gainesville, Florida); Peng Jiang (Gainesville, Florida); Tianwei Xie (Gainesville, Florida) |
| ABSTRACT | Embodiments of the present disclosure provide for methods of detecting, sensors (e.g., chromogenic sensor), kits, compositions, and the like that related to or use tunable macroporous polymer. In an aspect, tunable macroporous materials as described herein can be used to determine the presence of a certain type(s) and quantity of liquid in a liquid mixture. |
| FILED | Tuesday, September 06, 2022 |
| APPL NO | 17/903312 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/81 (20130101) C08G 18/6755 (20130101) C08G 2101/00 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 9/26 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/25 (20130101) G01N 21/78 (20130101) Original (OR) Class G01N 21/255 (20130101) G01N 21/272 (20130101) G01N 33/2852 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230025974 | Yang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY (Hoboken, New Jersey) |
| ASSIGNEE(S) | THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY (Hoboken, New Jersey) |
| INVENTOR(S) | Eui-Hyeok Yang (Fort Lee, New Jersey); Jian Xu (West Lafayette, Indiana); Wei Xu (Farmingdale, New York); Brendan Englot (New York, New York); Chang-Hwan Choi (Tenafly, New Jersey) |
| ABSTRACT | Smart membranes (14) are integrated into a small, unmanned surface vessel (20) to enable the efficient, automated cleanup of oil spills. Such a vessel (20) has the potential to provide a low-cost, modular solution for day-to-day oil-spill cleanup operations, especially in confined aquatic areas, such as under piers and in the small spaces between marine vessels and piers. The smart membranes (14) are provided on the surface of a conveyor belt (34) that circulates the membranes (14) through the surrounding body of water (10) for oil collection, as well as through an internal reduction chamber (22) of the vessel (20) for oil release. The smart membranes (14) are adapted to attract and repel oil (12) in response to low-voltage commands applied across the conveyor belt (34), using a process that is repeatable for a number of cycles, offering high efficiency and long durability (FIG. 5). |
| FILED | Thursday, August 04, 2022 |
| APPL NO | 17/881406 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/40 (20130101) Original (OR) Class C02F 1/285 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230026506 | Moran et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nancy Moran (Austin, Texas); Jeffrey Barrick (Austin, Texas); Sean Leonard (Austin, Texas) |
| ABSTRACT | Provided herein are genetically engineered bacteria that are native to a host insect microbiome. Further provided are methods of inducing RNA interference in an insect, such as a bee, by administering the genetically engineered bacteria. |
| FILED | Thursday, May 19, 2022 |
| APPL NO | 17/748315 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 2227/706 (20130101) Fodder A23K 10/18 (20160501) A23K 50/90 (20160501) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 48/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 15/746 (20130101) C12N 2310/20 (20170501) C12N 2310/141 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230026776 | SPEHR et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | INCUBE LABS, LLC (San Jose, California) |
| ASSIGNEE(S) | INCUBE LABS, LLC (San Jose, California) |
| INVENTOR(S) | Paul SPEHR (San Antonio, Texas); Charles Gregory NELSON (New Braunfels, Texas); Varghese K. GEORGE (San Jose, California); Isabell PINA (San Antonio, Texas) |
| ABSTRACT | A cuff is described for a target anatomic feature within a body, along with a system for utilizing the cuff. The cuff includes a band defining a circumferential opening extending along a length of the band; and a pair of engagement surfaces defined by or affixed to the cuff, the engagement surfaces structured for application of a spreading force to be distributed continuously along a portion of the circumferential opening, thereby increasing the circumferential opening and expanding the cuff for a closed configuration to an open configuration sized for placement of the cuff. The cuff is structured to remain in the closed configuration in the absence of the spreading force and automatically return to the closed configuration after removal of the spreading force. |
| FILED | Thursday, October 15, 2020 |
| APPL NO | 17/787148 |
| CURRENT CPC | Shirts; Underwear; Baby Linen; Handkerchiefs A41B 7/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230026914 | NEMANICK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Aerospace Corporation (El Segundo, California) |
| ASSIGNEE(S) | The Aerospace Corporation (El Segundo, California) |
| INVENTOR(S) | Eric Joseph NEMANICK (Santa Monica, California); Robert G. WILL (Redondo Beach, California) |
| ABSTRACT | An apparatus for monitoring health of one or more cells in a battery includes a health monitoring system configured to measure voltage on one or more cells when a waveform is injected into the one or more cells. The waveform is measured at an end of a pulse for each current. |
| FILED | Wednesday, October 05, 2022 |
| APPL NO | 17/938108 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/371 (20190101) G01R 31/392 (20190101) Original (OR) Class G01R 31/396 (20190101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 7/005 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230027059 | AMINI |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trallhead Biosystems Inc. (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nooshin AMINI (Cleveland, Ohio) |
| ABSTRACT | Methods for generating human committed midbrain neural stem cells (NSCs) and midbrain neural progenitor cells (midbrain NPCs) from human pluripotent stem cells are provided using chemically-defined culture media that allow for generation of the midbrain NPCs in as little as six days. The midbrain NPCs can be further differentiated to mature dopaminergic neurons. Culture media, isolated cell populations and kits are also provided. |
| FILED | Thursday, May 19, 2022 |
| APPL NO | 17/748323 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/47 (20130101) A61K 31/52 (20130101) A61K 31/166 (20130101) A61K 31/245 (20130101) A61K 31/506 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0606 (20130101) C12N 5/0619 (20130101) Original (OR) Class C12N 2501/16 (20130101) C12N 2501/115 (20130101) C12N 2501/119 (20130101) C12N 2501/155 (20130101) C12N 2501/415 (20130101) C12N 2501/727 (20130101) C12N 2506/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230027126 | DI FRANCESCO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Maria Emilia DI FRANCESCO (Houston, Texas); Philip JONES (Houston, Texas); Timothy Joseph MCAFOOS (Pearland, Texas) |
| ABSTRACT | The present invention relates to ethanediamine-heterocycle compounds that are able to act as inhibitors of PRMTs (protein arginine methyltransferases) for treating cancer and other diseases mediated by PRMTs. |
| FILED | Tuesday, May 04, 2021 |
| APPL NO | 17/307568 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/00 (20180101) A61P 35/02 (20180101) Heterocyclic Compounds C07D 471/04 (20130101) Original (OR) Class C07D 487/04 (20130101) C07D 498/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230027270 | RUBENSTEIN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Brown University (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brenda RUBENSTEIN (Providence, Rhode Island); Jacob Karl ROSENSTEIN (Providence, Rhode Island); Christopher ARCADIA (Providence, Rhode Island); Shui Ling CHEN (Harrisburg, Pennsylvania); Amanda Doris DOMBROSKI (Cranston, Rhode Island); Joseph D. GEISER (Barrington, Rhode Island); Eamonn KENNEDY (West Warwick, Rhode Island); Eunsuk KIM (Providence, Rhode Island); Kady M. OAKLEY (North Attleboro, Massachusetts); Sherief REDA (Barrington, Rhode Island); Christopher ROSE (Providence, Rhode Island); Jason Kelby SELLO (Tiverton, Rhode Island); Hokchhay TANN (Providence, Rhode Island); Peter WEBER (Barrington, Rhode Island); Dana Jo Biechele-Speziale (North Providence, Rhode Island); Selahaddin GUMUS (North Providence, Rhode Island) |
| ABSTRACT | The invention provides methods for computing with chemicals by encoding digital data into a plurality of chemicals to obtain a dataset; translating the dataset into a chemical form; reading the data set; querying the dataset by performing an operation to obtain a perceptron; and analyzing the perceptron for identifying chemical structure and/or concentration of at least one of the chemicals, thereby developing a chemical computational language. The invention demonstrates a workflow for representing abstract data in synthetic metabolomes. Also presented are several demonstrations of kilobyte-scale image data sets stored in synthetic metabolomes, recovered at >99% accuracy. |
| FILED | Thursday, September 01, 2022 |
| APPL NO | 17/929279 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 99/007 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230027415 | Ma et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Florida State University Research Foundation, Inc. (Tallahassee, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Biwu Ma (Tallahassee, Florida); Qingquan He (Tallahassee, Florida) |
| ABSTRACT | Methods of passivating surfaces, composite materials, and electronic devices including the composite materials. The composite materials can include a passivated film, such as a metal halide perovskite passivated with an organic dye. The electronic devices may include solar cells. |
| FILED | Wednesday, March 02, 2022 |
| APPL NO | 17/684991 |
| CURRENT CPC | Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 9/0036 (20130101) H01G 9/2009 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0068 (20130101) H01L 51/0071 (20130101) H01L 51/0072 (20130101) H01L 51/0077 (20130101) H01L 51/448 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230027456 | Dosado |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Daniel M. Dosado (Bloomington, Indiana) |
| ABSTRACT | Provided is a method for enabling a semiconductor test system for testing field programmable gate arrays (FPGAs) to operate as a device programmer by converting a serial vector format (SVF) file containing a bitstream and converting the file to a vector compatible with the semiconductor test system. When executed on an HP93K test system, as an example, the vector generates JTAG (Joint Test Action Group) signals, which program the bitstream into a Field Programmable Gate Array (FPGA). The inventive method eliminates the need for a separate computer system that is normally required to run FPGA programming software and also eliminates the need to use FPGA vendor provided JTAG programming pods. Eliminating the need for the vendor software, a separate computer system, and programming pods reduces equipment cost, maintenance, and streamlines the electrical test, evaluation, and characterization of FPGAs. |
| FILED | Wednesday, July 20, 2022 |
| APPL NO | 17/869186 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/318519 (20130101) G01R 31/318555 (20130101) Original (OR) Class G01R 31/318572 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230027521 | Hoffman, JR. et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher M. Hoffman, JR. (Odenton, Maryland); Zhiyong Xia (Rockville, Maryland); James K. Johnson (Silver Spring, Maryland) |
| ABSTRACT | Contaminant-sequestering coatings include a network of hydrolyzed silane compounds including (i) a plurality of fluorinated functionalities, and (ii) a plurality of thiol functional groups are provided. The network of hydrolyzed silane compounds includes a fluorinated silane including (a) a hydrophilic polar head region. The polar head region includes one or multiple units of ethylene glycol (EG) functionality, (b) a fluorine-containing region, and (c) an anchor region including a silicon atom. The contaminant-sequestering coatings may sequester one or more per- and polyfluoroalkyl substances (PFAS), heavy metals, biological species, or any combination thereof. |
| FILED | Monday, August 22, 2022 |
| APPL NO | 17/892222 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/62 (20130101) C02F 1/288 (20130101) Original (OR) Class C02F 1/583 (20130101) C02F 2101/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230027534 | Brewer |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tony Brewer (Plano, Texas) |
| ABSTRACT | Disclosed in some examples are systems, methods, devices, and machine-readable mediums to detect and terminate programmable atomic transactions that are stuck in an infinite loop. In order to detect and terminate these transactions, the programmable atomic unit may use an instruction counter that increments each time an instruction is executed during execution of a programmable atomic transaction. If the instruction counter meets or exceeds a threshold instruction execution limit without reaching the termination instruction, the programmable atomic transaction may be terminated, all resources used (e.g., memory locks) may be freed, and a response may be sent to a calling processor. |
| FILED | Tuesday, October 20, 2020 |
| APPL NO | 17/074834 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/325 (20130101) Original (OR) Class G06F 9/466 (20130101) G06F 15/781 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230027620 | AAKALU |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vinay Kumar AAKALU (Chicago, Illinois) |
| ABSTRACT | A synthetic peptide including the sequence SHXGY (SEQ ID NO:2) is described as are methods of using the same for promoting wound healing and epithelial cell migration. |
| FILED | Wednesday, November 25, 2020 |
| APPL NO | 17/778138 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1729 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/02 (20180101) A61P 27/02 (20180101) A61P 31/04 (20180101) Peptides C07K 14/4723 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230027624 | Nieto et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andy Nieto (Fremont, California); Andrew James Reinhart (Goose Creek, South Carolina); Troy Y. Ansell (Marina, California); Walter Smith (Monterey, California) |
| ABSTRACT | This disclosure, and the exemplary embodiments provided herein, include AM processed Ti-MMCs reinforced with either aluminum oxide or tantalum pentoxide. According to an exemplary embodiment, composite feedstock powders of Ti-6Al-4V (Ti64) with 1% and 3% (by volume) reinforcements of either nano-Al2O3 or Ta2O5 are prepared by high energy ball milling and then 3-D printed using SLM. |
| FILED | Wednesday, May 04, 2022 |
| APPL NO | 17/736883 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 9/04 (20130101) B22F 10/28 (20210101) B22F 10/47 (20210101) Original (OR) Class B22F 2009/043 (20130101) B22F 2301/205 (20130101) B22F 2302/253 (20130101) B22F 2304/10 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/10 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230027890 | Zhao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | University of Southern California (Los Angeles, California) |
| INVENTOR(S) | Yajie Zhao (Los Angeles, California); Jing Yang (Los Angeles, California); Hanyuan Xiao (Los Angeles, California) |
| ABSTRACT | Methods and systems are provided for rendering photo-realistic images of a subject or an object using a differentiable neural network for predicting indirect light behavior. In one example, the differentiable neural network outputs a volumetric light map comprising a plurality of spherical harmonic representations. Further, using a reflectance neural network, roughness and scattering coefficients associated with the subject or the object is computed. The volumetric light map, as well as the roughness and scattering coefficients are the utilized for rendering a final image under one or more of a desired lighting condition, desired camera view angle, and/or with a desired visual effect (e.g., expression change). |
| FILED | Tuesday, May 03, 2022 |
| APPL NO | 17/735869 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 15/04 (20130101) G06T 15/10 (20130101) G06T 15/80 (20130101) G06T 15/506 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230028020 | Jonker et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Berend T. Jonker (Waldorf, Maryland); Connie H. Li (Alexandria, Virginia); Kathleen M. McCreary (Washington, District of Columbia); Olaf M.J. van 't Erve (Falls Church, Virginia) |
| ABSTRACT | Heterostructures include a layer of a two-dimensional material placed on a multiferroic layer. An ordered array of differing polarization domains in the multiferroic layer produces corresponding domains having differing properties in the two-dimensional material. When the multiferroic layer is ferroelectric, the ferroelectric polarization domains in the layer produce local electric fields that penetrate the two-dimensional material. The local electric fields modulate the charge carriers and carrier density on a nanometer length scale, resulting in the formation of lateral p-n or p-i-n junctions, and variations thereof appropriate for device functions. |
| FILED | Wednesday, September 28, 2022 |
| APPL NO | 17/955072 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/4141 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/187 (20130101) H01L 21/02658 (20130101) H01L 29/66977 (20130101) Original (OR) Class H01L 29/78696 (20130101) H01L 33/002 (20130101) H01L 33/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230028442 | SHOLL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas R. SHOLL (Gainesville, Florida); Kamran MOHSENI (Gainesville, Florida) |
| ABSTRACT | A soft structure fiber reinforcement and actuation technology is provided. In an example embodiment, the tendon-driven, fiber-reinforced elastomer membrane comprises an elastomer matrix material and a fiber array embedded within the elastomer matrix material. The one or more tendons are not mechanically bonded to the elastomer matrix material, such that the one or more embedded tendons are able to move through the elastomer matrix material. One or more apparatuses may employ one or more such tendon-driven, fiber-reinforced elastomer membranes for use in a variety of applications. |
| FILED | Friday, May 20, 2022 |
| APPL NO | 17/664237 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/142 (20130101) B25J 9/1075 (20130101) Original (OR) Class Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/046 (20130101) C08J 2383/04 (20130101) C08J 2423/28 (20130101) C08J 2427/12 (20130101) C08J 2427/16 (20130101) C08J 2471/10 (20130101) C08J 2477/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230029034 | SHUKLA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Brown University (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anita SHUKLA (East Greenwich, Rhode Island); Dahlia ALKEKHIA (Providence, Rhode Island); Chao YU (Providence, Rhode Island) |
| ABSTRACT | The invention provides a “host-guest” supramolecular hydrogel. The hydrogel contains an AAm/NVP interpenetrating polymer network (IPN) with supramolecular cross-linkers assembled from β-lactam/adamantane-containing guest molecule with host polymeric cyclodextrin (PCD). An advantage of this hydrogel is that because of the molecular association of polymeric cyclodextrin and adamantane, the supramolecular hydrogels self-heal without any external stimuli after the hydrogels are severed. The invention also provides methods of making the hydrogel, methods of making the synthesis intermediates, and methods of diagnosis or treatment of β-lactamase-containing bacteria. |
| FILED | Wednesday, October 28, 2020 |
| APPL NO | 17/772466 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6903 (20170801) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/075 (20130101) Original (OR) Class C08J 2300/208 (20130101) C08J 2333/26 (20130101) C08J 2405/16 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230029192 | Hendrix et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Justin W. Hendrix (Washington, District of Columbia); Carlos M. Murillo (King George, Virginia) |
| ASSIGNEE(S) | United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Justin W. Hendrix (Washington, District of Columbia); Carlos M. Murillo (King George, Virginia) |
| ABSTRACT | A method is provided for producing metal hybrid graphene. The method includes providing a ball mill chamber filled with inert gas and metal balls; inserting graphene, nanographite, and nanosized transition metal; into the chamber; turning the chamber; and extracting the metal hybrid graphene. The transition metal is at least one of nickel, copper, cobalt, tungsten, iron, chromium and/or manganese. |
| FILED | Wednesday, October 28, 2020 |
| APPL NO | 17/082309 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 9/04 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/184 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230029257 | KISHI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Jocelyn KISHI (Boston, Massachusetts); Ninning LIU (Boston, Massachusetts); Sinem SAKA (Allston, Massachusetts); Peng YIN (Brookline, Massachusetts); Kuanwei SHENG (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein are compositions, kits, and methods for nucleic acid barcoding. The barcode compositions provided herein can be used to linearly, combinatorially, or spatially barcode a plurality of targets in a sample. Also provided herein is a device for use in a barcoding method provided herein comprising a light source and a sample holder. |
| FILED | Friday, December 11, 2020 |
| APPL NO | 17/783750 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6818 (20130101) Original (OR) Class C12Q 1/6841 (20130101) C12Q 2600/16 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230029309 | Graetz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Kathrin Graetz (Cambridge, Massachusetts); Christopher A. Schuh (Wayland, Massachusetts) |
| ABSTRACT | Titanium-containing alloys are generally described. The titanium-containing alloys are, according to certain embodiments, nanocrystalline. According to certain embodiments, the titanium-containing alloys have high relative densities. The titanium-containing alloys can be relatively stable, according to certain embodiments. Inventive methods for making titanium-containing alloys are also described herein. The inventive methods for making titanium-containing alloys can involve, according to certain embodiments, sintering nanocrystalline particulates comprising titanium and at least one other metal to form a titanium-containing nanocrystalline alloy. |
| FILED | Friday, April 29, 2022 |
| APPL NO | 17/733944 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 2999/00 (20130101) Alloys C22C 1/0458 (20130101) C22C 14/00 (20130101) Original (OR) Class C22C 2200/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20230021439 | Song et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ESS TECH, INC. (Wilsonville, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yang Song (West Linn, Oregon); Kenneth Kiyoshi Fisher (Portland, Oregon); Timothy McDonald (Portland, Oregon) |
| ABSTRACT | Methods and systems are provided for transporting and hydrating a redox flow battery system with a portable field hydration system. In one example, the redox flow battery system may be hydrated with the portable field hydration system in a dry state, in the absence of liquids. In this way, a redox flow battery system may be assembled and transported from a battery manufacturing facility to an end-use location off-site while the redox flow battery system is in the dry state, thereby reducing shipping costs, design complexities, as well as logistical and environmental concerns. |
| FILED | Thursday, September 29, 2022 |
| APPL NO | 17/936781 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/86 (20130101) H01M 8/188 (20130101) Original (OR) Class H01M 8/04119 (20130101) H01M 8/04225 (20160201) H01M 8/04283 (20130101) H01M 50/60 (20210101) H01M 2004/8684 (20130101) H01M 2004/8689 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230021734 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kunlei Liu (Lexington, Kentucky); Mark Crocker (Georgetown, Kentucky); Heather Nikolic (Stamping Ground, Kentucky) |
| ABSTRACT | A carbon dioxide (CO2) capture and utilization system captures CO2 from flue gas and utilizes the same to enhance algae or cyanobacteria growth. The system generally comprises a CO2 capture unit and a utilization unit that is in fluid communication with the CO2 capture unit. The CO2 capture unit includes a membrane CO2 absorber that captures CO2 from incoming flue gas to produce a CO2-rich solvent. The utilization unit processes the CO2-rich solvent to produce a product stream that includes CO2 and NH3 in a predetermined CO2:NH3 ratio. The product stream is delivered to a cultivation subsystem of the utilization of the unit including one or more species of algae or cyanobacteria. A method for capturing and utilizing CO2 is also provided herein. |
| FILED | Tuesday, July 19, 2022 |
| APPL NO | 17/868585 |
| CURRENT CPC | Horticulture; Cultivation of Vegetables, Flowers, Rice, Fruit, Vines, Hops or Seaweed; Forestry; Watering A01G 33/00 (20130101) Separation B01D 53/78 (20130101) Original (OR) Class B01D 53/1406 (20130101) B01D 53/1425 (20130101) B01D 53/1475 (20130101) B01D 71/36 (20130101) B01D 2251/2065 (20130101) B01D 2257/504 (20130101) B01D 2258/0283 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230021795 | LIU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE UNIVERSITY OF CHICAGO (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xunshan LIU (Chicago, Illinois); Luping YU (Chicago, Illinois); Valerii SHARAPOV (Chicago, Illinois) |
| ABSTRACT | Described herein is a novel polymerization method that is useful for synthesizing regioregular conjugated polymers from electron rich aromatic monomers and oligomers of electron rich aromatic monomers. |
| FILED | Wednesday, November 11, 2020 |
| APPL NO | 17/778550 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 61/126 (20130101) Original (OR) Class C08G 2261/11 (20130101) C08G 2261/18 (20130101) C08G 2261/228 (20130101) C08G 2261/1426 (20130101) C08G 2261/3243 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/11 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230022706 | LaPlant et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven Todd LaPlant (Kansas City, Missouri); Matthew Wayne Trimmer (Paola, Kansas); Nicholas Christopher Ogden (Lee's Summit, Missouri); Mark Douglas Smith (Olathe, Kansas); Ruben Arturo Pino (Kansas City, Missouri) |
| ABSTRACT | Systems and methods for using a non-stick conductive material to automate tool touch-off in an additive manufacturing process are provided. A substrate comprises a first conductive layer, an intermediate binder layer, and a second non-stick conductive layer. The non-stick conductive layer may comprise perfluoroalkoxy alkanes and carbon nanotubes. An electrical connection may be made between the first conductive layer and the second non-stick conductive layer. When used with an additive manufacturing device, when the nozzle of the device contacts the substrate, a circuit may close resulting in a detectable voltage drop. When the voltage drop is detected, a reference point for the additive manufacturing device may be set. |
| FILED | Wednesday, July 21, 2021 |
| APPL NO | 17/381944 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/245 (20170801) Original (OR) Class B29C 64/393 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 30/00 (20141201) B33Y 50/02 (20141201) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/037 (20130101) C09D 11/52 (20130101) C09D 11/102 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230022747 | Lin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jenshan Lin (Gainesville, Florida); Lawrence Fomundam (Gainesville, Florida) |
| ABSTRACT | Various examples are provided for wireless power transfer to implants. In one example, a system includes a radio frequency (RF) power source and a transmitter (TX) array comprising an excitation coil and resonant coils distributed about the excitation coil. The TX array can transfer power from the RF power source to a biomedical implant inserted below a skin surface of a subject when the TX array is positioned on the skin surface adjacent to the biomedical implant. A receiver (RX) coil of the biomedical implant can inductively couple with the TX array for the power transfer. The resonant coils can allow power transfer when the RX coil is not aligned with the excitation coil. |
| FILED | Thursday, July 28, 2022 |
| APPL NO | 17/875552 |
| CURRENT CPC | Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 38/14 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 50/12 (20160201) Original (OR) Class H02J 50/20 (20160201) H02J 50/402 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230022775 | Soenksen Martinez et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Luis Ruben Soenksen Martinez (Boston, Massachusetts); Nicolaas Angenent-Mari (Somerville, Massachusetts); Alexander S. Garruss (Cambridge, Massachusetts); James J. Collins (Newton, Massachusetts); George M. Church (Cambridge, Massachusetts); Katherine Collins (Cambridge, Massachusetts); Diogo M. Camacho (Cambridge, Massachusetts) |
| ABSTRACT | This disclosure provides riboregulators specific for particular viruses or for particular human transcription factors. The viral-specific riboregulators may be used to detect the presence of the particular virus, and this may enable diagnosis of an infection. The transcription factor specific riboregulators may be used to detect the presence and/or measure the level of the particular transcription factor, and this may enable diagnosis or prognosis of a particular condition such as cancer. |
| FILED | Friday, December 11, 2020 |
| APPL NO | 17/784899 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1089 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/701 (20130101) C12Q 1/6816 (20130101) Original (OR) Class C12Q 1/6886 (20130101) C12Q 1/6897 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230023187 | O'Brien et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battetlle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert C. O'Brien (Idaho Falls, Idaho); Allen A. Beasley (Idaho Falls, Idaho) |
| ABSTRACT | A sensor assembly for determining an operating characteristic of a nuclear reactor. The sensor assembly includes a solid-state lasing media doped with a fissile species and disposable within a core of the nuclear reactor and an optical fiber operably coupled to the solid-state lasing media and configured to extend out of the core of the nuclear reactor and to control system of reactor. The fissile species include one or more of uranium, plutonium, americium, or californium. A method of determining an operating characteristic of a nuclear reactor includes during operation of the nuclear reactor; receiving from the optical fiber a laser light, analyzing the laser light, and based on the analysis of the laser light, determining the operating characteristic of the nuclear reactor. |
| FILED | Tuesday, January 05, 2021 |
| APPL NO | 17/758395 |
| CURRENT CPC | Nuclear Reactors G21C 17/108 (20130101) Original (OR) Class Nuclear Power Plant G21D 3/001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230023780 | Steen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | LYGOS, Inc. (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric Steen (Berkeley, California); Jeffrey Dietrich (Berkeley, California); Johan Van Walsem (Berkeley, California) |
| ABSTRACT | A process for the preparation of bio-based malonic acid and crystalline calcium malonate is provided. The calcium malonate is highly pure and provides a source of malonic acid made from a renewable carbon source rather than existing processes which rely on the use of petroleum-based products. The calcium malonate provides an improved source of malonic acid, which is important to many industrial processes. |
| FILED | Thursday, April 07, 2022 |
| APPL NO | 17/658406 |
| CURRENT CPC | General Methods of Organic Chemistry; Apparatus Therefor C07B 63/02 (20130101) C07B 2200/13 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/02 (20130101) C12N 1/16 (20130101) C12N 1/165 (20210501) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/46 (20130101) Original (OR) Class Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/84 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230024749 | Truax et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | TerraPower, LLC (Bellevue, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John E. Truax (Bellevue, Washington); Trevor R. McWilliams (Barnhart, Missouri) |
| ABSTRACT | A method of handling spent nuclear fuel assemblies immerses the spent nuclear fuel assemblies in water in a relatively short time period when compared to traditional methods. A spent nuclear fuel assembly is removed from a nuclear reactor core, inserted into a sodium removal machine having a receiver, a cleaning vessel, and an elevator. A cleaning fluid is applied to the cleaning vessel and fuel assembly, and the fuel assembly is flushed with water while in the cleaning vessel. The cleaning vessel is at least partially submerged in the spent fuel pool during cleaning to provide passive heat removal. The cleaning vessel is lowered by an elevator into the spent fuel pool. The fuel assembly may then be loaded into a rack and/or a cask for long-term storage. |
| FILED | Tuesday, July 12, 2022 |
| APPL NO | 17/863346 |
| CURRENT CPC | Nuclear Reactors G21C 19/08 (20130101) G21C 19/19 (20130101) G21C 19/32 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230024845 | WANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jian-Ping WANG (Shoreview, Minnesota); YanFeng JIANG (Minneapolis, Minnesota) |
| ABSTRACT | Techniques are disclosed for milling an iron-containing raw material in the presence of a nitrogen source to generate anisotropically shaped particles that include iron nitride and have an aspect ratio of at least 1.4. Techniques for nitridizing an anisotropic particle including iron, and annealing an anisotropic particle including iron nitride to form at least one α″-Fe16N2 phase domain within the anisotropic particle including iron nitride also are disclosed. In addition, techniques for aligning and joining anisotropic particles to form a bulk material including iron nitride, such as a bulk permanent magnet including at least one α″-Fe16N2 phase domain, are described. Milling apparatuses utilizing elongated bars, an electric field, and a magnetic field also are disclosed. |
| FILED | Thursday, September 15, 2022 |
| APPL NO | 17/945203 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/054 (20220101) B22F 1/0551 (20220101) B22F 9/04 (20130101) Original (OR) Class B22F 2009/045 (20130101) B22F 2998/10 (20130101) B22F 2999/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 21/0622 (20130101) Alloys C22C 33/02 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 8/26 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 1/065 (20130101) H01F 1/083 (20130101) H01F 1/086 (20130101) H01F 41/0266 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230024854 | SHI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ye SHI (Pasadena, California); Julia R. GREER (Pasadena, California); Harry A. ATWATER (Pasadena, California); Ognjen ILIC (Pasadena, California) |
| ABSTRACT | A membrane for water collection may include a sheet having a top surface and a bottom surface, and a plurality of conical structures disposed on the top surface of the sheet, the conical structures comprising a hydrogel material. Each conical structure of the plurality of conical structures may have a height of 1 mm to 50 mm, wherein height is measured from the top surface of the sheet to an apex of a conical structure. Each conical structure of the plurality of conical structures may have an apex angle of 10 to 60 degrees. |
| FILED | Tuesday, July 12, 2022 |
| APPL NO | 17/862916 |
| CURRENT CPC | Separation B01D 53/261 (20130101) B01D 61/364 (20130101) B01D 69/02 (20130101) B01D 69/147 (20130101) Original (OR) Class B01D 69/1411 (20220801) B01D 71/381 (20220801) B01D 2311/2626 (20130101) B01D 2311/2674 (20220801) B01D 2313/367 (20220801) B01D 2325/04 (20130101) B01D 2325/36 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/447 (20130101) C02F 2201/009 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230024915 | Hopkinson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Philip Hopkinson (Morgantown, West Virginia); Lingxiang Zhu (Bethel Park, Pennsylvania) |
| ABSTRACT | The present invention provides highly permeable and porous polybenzimidazole membranes, methods of making them, and their application as a high-performance membrane support for gas separation composite membranes. The polybenzimidazole membranes are bonded to a fabric substrate. |
| FILED | Friday, July 16, 2021 |
| APPL NO | 17/378632 |
| CURRENT CPC | Separation B01D 53/228 (20130101) B01D 67/0013 (20130101) B01D 67/0016 (20130101) B01D 67/0095 (20130101) B01D 69/02 (20130101) B01D 69/105 (20130101) B01D 69/122 (20130101) B01D 71/62 (20130101) Original (OR) Class B01D 2325/04 (20130101) B01D 2325/20 (20130101) B01D 2325/025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230025406 | Wachsman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric D. Wachsman (, None); Liangbing Hu (Hyattsville, Maryland); Venkataraman Thangadurai (Calgary, Canada); Gregory Thomas Hitz (Riverdale Park, Maryland); Dennis McOwen (College Park, Maryland) |
| ABSTRACT | Batteries and battery cells are described including batteries and battery cells having solid-state components such as porous and/or dense solid state components. Aspects of dimensions, porosity and pore structure are also described. |
| FILED | Friday, September 23, 2022 |
| APPL NO | 17/951873 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/80 (20130101) Original (OR) Class H01M 10/0525 (20130101) H01M 10/0565 (20130101) H01M 2004/021 (20130101) H01M 2300/0085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230025444 | GLEICK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeremy Robert GLEICK (Pleasanton, California); Razi-Ul Muhammad HAQUE (San Francisco, California) |
| ABSTRACT | The present disclosure relates to a method for at least one of forming a part or modifying a part, and a system therefor. The method involves initially providing a planar structure having a first material layer disposed on a second material layer. A lithographic operation including greyscale printing is performed to produce a resist material layer on the first material layer, with the resist material layer having a predetermined three-dimensional pattern extending along X, Y and Z axes, with features helping to define the three-dimensional pattern having differing dimensions along the Z axis, and which acts as a mask. An etch process is then performed, using the mask provided by the resist material layer, to etch the first material layer to impart the pattern of the mask as an etched pattern into the first material layer in accordance with a predetermined selectivity etching ratio, such that the etched pattern in the first material layer includes features formed with greater dimensions than corresponding features in the mask of the resist material layer. |
| FILED | Thursday, July 07, 2022 |
| APPL NO | 17/860049 |
| CURRENT CPC | Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/16 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/308 (20130101) H01L 21/02057 (20130101) H01L 21/3065 (20130101) Original (OR) Class H01L 21/67069 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230025748 | Selter et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas Matthew Selter (Blue Springs, Missouri); Justin Schlitzer (Stillwell, Kansas); Surbhi Mahajan Du (Overland Park, Kansas) |
| ABSTRACT | A multi-layer coating on an outer surface of a substrate includes a first layer applied directly to the outer surface of the substrate. The first layer includes diamond-like carbon (DLC) configured to mitigate metal whisker formation. A second layer is applied on a top surface of the first layer. The second layer is a conformal coating that includes a second material configured to bind to the top surface of the first layer and fill any microfractures that may form in the first layer. Optionally, a third layer is applied on a top surface of the second layer and includes DLC configured to protect the second layer from oxidation and degradation. |
| FILED | Tuesday, July 20, 2021 |
| APPL NO | 17/380443 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/16 (20130101) C23C 14/221 (20130101) C23C 14/0611 (20130101) C23C 16/0272 (20130101) C23C 16/276 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/053 (20130101) Original (OR) Class H05K 1/0306 (20130101) H05K 3/285 (20130101) H05K 2201/0175 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230026596 | Yang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Jihui Yang (Seattle, Washington); Jun Liu (Seattle, Washington); Xiang Han (Seattle, Washington) |
| ABSTRACT | The present disclosure describes a lithium solid state battery, including a cathode that includes an active material such as lithium, and an additive having a lower melting point than the active material. The additive can provide a composite cathode where a cathode-electrolyte interphase has high electronic and ionic conductivity, good mechanical deformability, and high oxidation potential. |
| FILED | Wednesday, December 16, 2020 |
| APPL NO | 17/786305 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/382 (20130101) H01M 4/0471 (20130101) H01M 4/505 (20130101) H01M 4/525 (20130101) Original (OR) Class H01M 10/0525 (20130101) H01M 10/0562 (20130101) H01M 10/0565 (20130101) H01M 2004/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230027562 | SINGH |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Deere and Company (Moline, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | BRIJ N. SINGH (West Fargo, North Dakota) |
| ABSTRACT | Design and packaging of wide bandgap (WBG) power electronic power stages are disclosed herein. An example apparatus includes a first printed circuit board (PCB) including: a first voltage phase circuit cluster; a second voltage phase circuit cluster; and a cluster of traces, the cluster of traces routed substantially perpendicular to the second voltage phase circuit cluster; a second PCB positioned below the first PCB; and a connector to connect the first PCB to the second PCB, the connector electrically coupled to the first voltage phase circuit cluster by the cluster of traces. |
| FILED | Friday, September 30, 2022 |
| APPL NO | 17/958093 |
| CURRENT CPC | Arrangement or Mounting of Propulsion Units or of Transmissions in Vehicles; Arrangement or Mounting of Plural Diverse Prime-movers in Vehicles; Auxiliary Drives for Vehicles; Instrumentation or Dashboards for Vehicles; Arrangements in Connection With Cooling, Air Intake, Gas Exhaust or Fuel Supply of Propulsion Units in Vehicles B60K 1/00 (20130101) Vehicles, Vehicle Fittings, or Vehicle Parts, Not Otherwise Provided for B60R 16/03 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/4735 (20130101) Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors H01R 12/523 (20130101) Installation of Electric Cables or Lines, or of Combined Optical and Electric Cables or Lines H02G 5/10 (20130101) Dynamo-electric Machines H02K 7/006 (20130101) H02K 11/33 (20160101) Original (OR) Class H02K 2211/03 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/144 (20130101) H05K 1/0233 (20130101) H05K 7/20272 (20130101) H05K 7/20927 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230027805 | Almassalkhi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Vermont and State Agricultural College (Burlington, Vermont) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mads Almassalkhi (South Burlington, Vermont); Hani Mavalizadeh (Burlington, Vermont); Luis A. Duffaut Espinosa (Williston, Vermont) |
| ABSTRACT | Demand response methodologies for primary frequency response (PFR) for under or over frequency events. Aspects of the present disclosure include methods for controlling a fleet of distributed energy resources equipped for PFR and quantifying in real time an amount of primary frequency control capacity available in the fleet. In some examples, the DERs may be configured to consume and discharge electrical energy in discrete energy packets and be equipped with a frequency response local control law that causes each DER to independently and instantaneously interrupt an energy packet in response to local frequency measurements indicating a grid disturbance event has occurred. |
| FILED | Thursday, July 08, 2021 |
| APPL NO | 17/305491 |
| CURRENT CPC | Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/144 (20200101) Original (OR) Class H02J 3/381 (20130101) H02J 2310/54 (20200101) H02J 2310/60 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230028170 | Song et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ESS TECH, INC. (Wilsonville, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yang Song (West Linn, Oregon); Craig E. Evans (West Linn, Oregon) |
| ABSTRACT | A method of rebalancing electrolytes in a redox flow battery system comprises directing hydrogen gas generated on the negative side of the redox flow battery system to a catalyst surface, and fluidly contacting the hydrogen gas with an electrolyte comprising a metal ion at the catalyst surface, wherein the metal ion is chemically reduced by the hydrogen gas at the catalyst surface, and a state of charge of the electrolyte and pH of the electrolyte remain substantially balanced. |
| FILED | Friday, September 30, 2022 |
| APPL NO | 17/937391 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/004 (20130101) H01M 8/20 (20130101) H01M 8/188 (20130101) Original (OR) Class H01M 8/0693 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230028285 | Bahar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | FFI IONIX IP, INC. (WILMINGTON, Delaware) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bamdad Bahar (Georgetown, Delaware); Luyu Jin (Harbeson, Delaware); William Parmelee (Seaford, Delaware); Jacob Zerby (Harbeson, Delaware) |
| ABSTRACT | A water purification system utilizes an ionomer membrane and mild vacuum to draw water from source water through the membrane. A water source may be salt water or a contaminated water source. The water drawn through the membrane passes across the condenser chamber to a condenser surface where it is condensed into purified water. The condenser surface may be metal or any other suitable surface and may be flat or pleated. In addition, the condenser surface may be maintained at a lower temperature than the water on the water source side of the membrane. The ionomer membrane may be configured in a cartridge, a pleated or flat plate configuration. A latent heat loop may be configured to carry the latent heat of vaporization from the condenser back to the water source side of the ionomer membrane. The source water may be heated by a solar water heater. |
| FILED | Monday, June 27, 2022 |
| APPL NO | 17/850507 |
| CURRENT CPC | Separation B01D 25/00 (20130101) Original (OR) Class Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/14 (20130101) C02F 9/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230028318 | Kuru et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Erkin Kuru (Cambridge, Massachusetts); Jonathan Rittichier (Cambridge, Massachusetts); George M. Church (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein are compounds (i.e., fluorogenic amino acids (FgAAs), e.g., compounds of Formulae (I), (II), (III), and (IV)) that can be used in fluorescent labeling of biomolecules (e.g., proteins) and/or cells. Also described herein are methods of labeling and detecting biomolecules and/or cells by incorporating the FgAA compounds described herein into the biomolecules and/or cells (e.g., by enzymatic incorporation). Also provided herein are biomolecules, cells, compositions, and kits comprising the FgAA compounds described herein. |
| FILED | Friday, November 06, 2020 |
| APPL NO | 17/774095 |
| CURRENT CPC | Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 11/06 (20130101) C09B 11/12 (20130101) C09B 23/04 (20130101) C09B 55/002 (20130101) Original (OR) Class C09B 57/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230028553 | Kelley et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian Michael Kelley (Livermore, California); Indrasis Chakraborty (Lafayette, California); Brian James Gallagher (Livermore, California); Daniel Matthew Merl (Livermore, California) |
| ABSTRACT | In an industrial control system (ICS), latent vectors are generated to represent identity or behaviors of host devices coupled to the ICS. A computing system captures communications transmitted by a host device across a network associated with the ICS. A set of values are extracted from one or more respective fields in the communication, then applied to a trained neural network. Values of a first set of fields are applied at an input layer of the trained neural network, while values of a second set of fields are applied at an output layer of the neural network. Based on the application of the neural network to the values extracted from the communication, the computing system generates a latent vector. |
| FILED | Friday, July 08, 2022 |
| APPL NO | 17/860852 |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/4185 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/0454 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230028705 | Li et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | Jing Li (Cranbury, New Jersey); Baiyan Li (East Brunswick, New Jersey) |
| ABSTRACT | Novel radioactive iodide molecular traps, in which one or more metal atoms are functionalized by coordinating to an amine containing two or more nitrogens, and methods of using the molecular traps to capture radioactive iodide. |
| FILED | Friday, July 15, 2022 |
| APPL NO | 17/812775 |
| CURRENT CPC | Separation B01D 53/02 (20130101) B01D 2253/31 (20130101) B01D 2253/204 (20130101) B01D 2253/306 (20130101) B01D 2253/308 (20130101) B01D 2257/2068 (20130101) B01D 2259/40083 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/226 (20130101) Original (OR) Class B01J 20/2808 (20130101) B01J 20/3425 (20130101) B01J 20/3475 (20130101) B01J 20/28066 (20130101) B01J 20/28083 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230028886 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Tennessee Research Foundation (Knoxville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fan Zhang (Knoxville, Tennessee); Jamie Baalis Coble (Knoxville, Tennessee) |
| ABSTRACT | A method of detecting an operational anomaly of an industrial system can include receiving operational values for a plurality of process parameters from an industrial system at a localized anomaly detection system, wherein the plurality of process parameters, accessing a machine learning model stored in a non-volatile memory system operating within the localized anomaly detection system, to determine predicted values for the process parameters based on the operational values of the process parameters received from the industrial system, and determining residual values for the process parameters, each representing a difference between a respective one of the predicted values and a respective one of the operational values. |
| FILED | Friday, November 20, 2020 |
| APPL NO | 17/756252 |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 23/0259 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230028927 | Pasqualini et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Renata Pasqualini (New Brunswick, New Jersey); Wadih Arap (New Brunswick, New Jersey); Fernanda Iamassaki Staquicini (New Brunswick, New Jersey); Fortunato Ferrara (Santa Fe, New Mexico); Sara D'Angelo (Santa Fe, New Mexico); Andrew R.M. Bradbury (Santa Fe, New Mexico) |
| ABSTRACT | Isolated or recombinant EphA5 or GRP78 targeting antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer. A method of rapidly identifying antibodies or antibody fragments for the treatment of cancer using a combination of in vitro and in vivo methodologies is also provided. |
| FILED | Friday, June 10, 2022 |
| APPL NO | 17/837943 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/07 (20130101) A61K 39/3955 (20130101) A61K 39/39558 (20130101) A61K 47/6803 (20170801) A61K 47/6817 (20170801) A61K 47/6843 (20170801) A61K 47/6849 (20170801) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/18 (20130101) C07K 16/28 (20130101) C07K 16/30 (20130101) Original (OR) Class C07K 16/3023 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1037 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57423 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230029316 | Reber et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Georgia Research Foundation, Inc. (Athens, Georgia) |
| ASSIGNEE(S) | University of Georgia Research Foundation, Inc. (Athens, Georgia) |
| INVENTOR(S) | Melanie A.R. Reber (Athens, Georgia); Nicholas D. Cooper (Athens, Georgia) |
| ABSTRACT | Apparatus include a mode-locked laser cavity configured to produce a mode-locked output beam, wherein the laser cavity includes a gain medium situated in the laser cavity and an intracavity optical coating filter situated in the laser cavity to receive an intracavity beam, wherein the intracavity optical coating filter has an attenuation profile configured to suppress laser oscillation over a selected portion of the gain bandwidth of the gain medium and to increase a bandwidth of the mode-locked output beam based on the suppression. Related optical coatings are disclosed. Methods of arranging coatings and reducing pulse duration are also disclosed. |
| FILED | Friday, July 22, 2022 |
| APPL NO | 17/871763 |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/0057 (20130101) H01S 3/0078 (20130101) H01S 3/1118 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20230021429 | Fang |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Shiyue Fang (Houghton, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shiyue Fang (Houghton, Michigan) |
| ABSTRACT | This invention relates to the use of base-labile protecting groups for stepwise synthesis of polymers including oligomers. One or more monomers that have a base-labile protecting group at one end and a leaving group at the other are used in synthetic cycles comprising deprotection under stronger basic conditions to remove the base-labile protecting group, and coupling with a monomer under weaker basic conditions to elongate the polymer without premature deprotection of the base-labile protecting group. Advantages of the invention include the possibility to shorten the synthetic cycle from three steps in prior art methods to two steps, more efficient deprotection, more efficient coupling, and the use of less harmful and less expensive chemicals. One of the goals for stepwise polymer synthesis is to prepare monodisperse and sequence-defined polymers. |
| FILED | Sunday, June 19, 2022 |
| APPL NO | 17/844023 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 43/126 (20130101) C07C 309/68 (20130101) C07C 309/73 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 65/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230021486 | TAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (Knoxville, Tennessee) |
| ASSIGNEE(S) | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (Knoxville, Tennessee) |
| INVENTOR(S) | Jindong TAN (Knoxville, Tennessee); Da HU (Louisville, Tennessee); Qiang HE (Knoxville, Tennessee); Shuai LI (Knoxville, Tennessee) |
| ABSTRACT | Provided are methods and apparatus for environment-adaptive robotic disinfecting. In an example, provided is a method that can include (i) creating, from digital images, a map of a structure; (ii) identifying a location of a robot in the structure; (iii) segmenting, using a machine learning-based classifying algorithm trained based on object affordance information, the digital images to identify potentially contaminated surfaces within the structure; (iv) creating a map of potentially contaminated surfaces within the structure; (v) calculating a trajectory of movement of the robot to move the robot to a location of a potentially contaminated surface in the potentially contaminated surfaces; and (vi) moving the robot along the trajectory of movement to position a directional decontaminant source adjacent to the potentially contaminated surface. Other methods, systems, and computer-readable media are also disclosed. |
| FILED | Wednesday, August 25, 2021 |
| APPL NO | 17/445898 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 2/24 (20130101) Manipulators; Chambers Provided With Manipulation Devices B25J 5/007 (20130101) B25J 9/161 (20130101) B25J 9/1664 (20130101) Original (OR) Class B25J 9/1669 (20130101) B25J 15/0019 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00671 (20130101) G06K 9/3233 (20130101) G06K 9/6257 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230021549 | LIM et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Soon Wei Daniel LIM (Cambridge, Massachusetts); Joon-Suh PARK (Cambridge, Massachusetts); Maryna Leonidivna MERETSKA (Cambridge, Massachusetts); Federico CAPASSO (Cambridge, Massachusetts); Ahmed Hassen Dorrah (Cambridge, Massachusetts) |
| ABSTRACT | Disclosed is a method of generating a functional singularity at a point or collection of points. The method may include determining a relationship between one or more parameters associated with a physical structure and a spatial gradient of field values of at least one of electromagnetic energy, sound energy, particle beam, or water waves manipulated by the physical structure, configuring, according to the relationship, the spatial gradient of field values to represent a functional singularity at a point, performing backpropagation using the spatial gradient of field values to obtain design parameters corresponding to values for the one or more parameters that achieve the functional singularity at the point, and producing a physical structure having the design parameters. |
| FILED | Wednesday, January 19, 2022 |
| APPL NO | 17/579460 |
| CURRENT CPC | Electric Digital Data Processing G06F 17/16 (20130101) G06F 17/148 (20130101) Original (OR) Class G06F 17/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230021621 | Chakrabartty et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shantanu Chakrabartty (St. Louis, Missouri); Ahana Gangopadhyay (St. Louis, Missouri) |
| ABSTRACT | Growth-transform (GT) neurons and their population models allow for independent control over spiking statistics and transient population dynamics while optimizing a physically plausible distributed energy functional involving continuous-valued neural variables. A backpropagation-less learning approach trains a GT network of spiking GT neurons by enforcing sparsity constraints on network spiking activity overall. Spike responses are generated because of constraint violations. Optimal parameters for a given task is learned using neurally relevant local learning rules and in an online manner. The GT network optimizes itself to encode the solution with as few spikes as possible and operate at a solution with the maximum dynamic range and away from saturation. Further, the framework is flexible enough to incorporate additional structural and connectivity constraints on the GT network. The framework formulation is used to design neuromorphic tinyML systems that are constrained in energy, resources, and network structure. |
| FILED | Wednesday, June 29, 2022 |
| APPL NO | 17/809713 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230021795 | LIU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE UNIVERSITY OF CHICAGO (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xunshan LIU (Chicago, Illinois); Luping YU (Chicago, Illinois); Valerii SHARAPOV (Chicago, Illinois) |
| ABSTRACT | Described herein is a novel polymerization method that is useful for synthesizing regioregular conjugated polymers from electron rich aromatic monomers and oligomers of electron rich aromatic monomers. |
| FILED | Wednesday, November 11, 2020 |
| APPL NO | 17/778550 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 61/126 (20130101) Original (OR) Class C08G 2261/11 (20130101) C08G 2261/18 (20130101) C08G 2261/228 (20130101) C08G 2261/1426 (20130101) C08G 2261/3243 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/11 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230022693 | Facchetti et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois); Flexterra, Inc. (Skokie, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Antonio F. Facchetti (Chicago, Illinois); Tobin J. Marks (Evanston, Illinois); Wei Huang (Deyang, China PRC); Jianhua Chen (Shenzhen, China PRC); Yu Xia (Northbrook, Illinois) |
| ABSTRACT | Photocurable compositions that combine redox-active semiconducting organic polymers with photocurable organic molecules are provided. Upon exposure to radiation, the photocurable compositions form ion-permeable, electrically conductive crosslinked organic films that can be used as conducting channels in n-channel or p-channel organic electrochemical transistors, including vertical organic electrochemical transistors (vOECTs). The vOECTs can be incorporated in complementary electronic circuits. |
| FILED | Tuesday, July 05, 2022 |
| APPL NO | 17/857596 |
| CURRENT CPC | Compositions of Macromolecular Compounds C08L 65/00 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/24 (20130101) C09D 165/00 (20130101) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 9/22 (20130101) H01G 9/26 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/283 (20130101) H01L 51/0036 (20130101) Original (OR) Class H01L 51/0043 (20130101) H01L 51/0566 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230022700 | Newton |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Indiana University Research and Technology Corporation (Indianapolis, Indiana) |
| ASSIGNEE(S) | Indiana University Research and Technology Corporation (Indianapolis, Indiana) |
| INVENTOR(S) | Irene Newton (Bloomington, Indiana) |
| ABSTRACT | Described herein are expression vectors encoding the Wolbachia protein WalE1. Also described are insects transformed with an expression vector of the present disclosure, and progeny thereof. Also described are methods for improving Wolbachia replication and transmission in its insect host by overexpressing WalE1 in the insect host. Improved Wolbachia replication and transmission provides for insect population control and pathogen resistance in insects, which can reduce disease transmission. |
| FILED | Wednesday, July 14, 2021 |
| APPL NO | 17/375764 |
| CURRENT CPC | Peptides C07K 14/195 (20130101) Original (OR) Class C07K 14/43563 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/62 (20130101) C12N 15/85 (20130101) C12N 15/113 (20130101) C12N 2310/20 (20170501) C12N 2800/22 (20130101) C12N 2800/105 (20130101) C12N 2830/75 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230023615 | Ahmad et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | DNAlite Therapeutics, Inc. (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mubhij Ahmad (Walnut Creek, California); Timothy Day (Oakland, California); Ismail Hafez (Concord, California); John Merritt (San Mateo, California) |
| ABSTRACT | Provided are delivery vehicles, and methods of making and using same for reaching epithelial cells, such as cells within mucus-containing environments, and delivery vehicles with improved stability in harsh environments, including in the gastrointestinal tract. |
| FILED | Monday, December 14, 2020 |
| APPL NO | 17/784700 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1272 (20130101) A61K 47/28 (20130101) A61K 48/0041 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/88 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230024038 | Jorabchi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgetown University (Washington, District of Columbia) |
| ASSIGNEE(S) | Georgetown University (Washington, District of Columbia) |
| INVENTOR(S) | Kaveh Jorabchi (Arlington, Virginia); Joseph Lesniewski (Washington, District of Columbia); Kunyu Zheng (Washington, District of Columbia); Samuel White (Washington, District of Columbia) |
| ABSTRACT | A method that includes introducing at least one analyte into a gas plasma; generating neutral species from atoms of the analyte in the gas plasma; preferentially transporting the neutral species downstream of the gas plasma relative to any ions produced in the gas plasma; and reacting the neutral species of the analyte with at least one reagent ion downstream of the plasma resulting in ion species of the analyte, wherein the at least one reagent ion is supplied by an independent ion source. |
| FILED | Thursday, February 25, 2021 |
| APPL NO | 17/785838 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/726 (20130101) G01N 30/7206 (20130101) G01N 30/7266 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/005 (20130101) Original (OR) Class H01J 49/0077 (20130101) H01J 49/105 (20130101) H01J 49/165 (20130101) H01J 49/168 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230024508 | Steinmetz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio); Trustees of Dartmouth College (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicole F. Steinmetz (Cleveland, Ohio); Amy M. Wen (Cleveland, Ohio); Steven Fiering (Hanover, New Hampshire); Patrick H. Lizotte (Cleveland, Ohio) |
| ABSTRACT | A method of treating cancer in a subject in need thereof includes administering in situ to the cancer a therapeutically effective amount of a virus or virus-like particle. |
| FILED | Friday, February 25, 2022 |
| APPL NO | 17/680813 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/704 (20130101) A61K 39/12 (20130101) Original (OR) Class A61K 2039/5258 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 35/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230025383 | Rucker et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hunter Bryant Gilbert (Baton Rouge, Louisiana); University of Tennessee Research Foundation (Knoxville, Tennessee) |
| ASSIGNEE(S) | University of Tennessee Research Foundation (Knoxville, Tennessee); Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| INVENTOR(S) | Daniel Caleb Rucker (Knoxville, Tennessee); Hunter Bryant Gilbert (Baton Rouge, Louisiana) |
| ABSTRACT | A concentric tube steerable device includes a plurality of tubes having a nested, concentric configuration. The tubes include an outer tube and an inner tube that extends coaxially within the outer tube. The inner tube terminates at a tip, and a pose of the tip is effectuated through individual or collective rotation or translation of the tubes about a tube axis. The concentric tube steerable device includes an actuator for rotating at least one tube about a respective tube axis, and a translator for translating at least one tube along a respective tube axis. Each tube includes a precurved portion and a corresponding axis of precurvature. For at least one tube, a flexural rigidity of the tube along its axis of precurvature is less than a flexural rigidity of the tube along a second axis that is perpendicular to the axis of precurvature, thereby improving stability of the tube. |
| FILED | Friday, June 24, 2022 |
| APPL NO | 17/848970 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 2034/301 (20160201) Manipulators; Chambers Provided With Manipulation Devices B25J 18/002 (20130101) B25J 18/005 (20130101) B25J 18/06 (20130101) B25J 18/025 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230025400 | McAlpine et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael C. McAlpine (Minneapolis, Minnesota); Guebum Han (Minneapolis, Minnesota); John C. Bischof (Saint Paul, Minnesota); Kanav Khosla (St Paul, Minnesota); Kieran T. Smith (Minneapolis, Minnesota) |
| ABSTRACT | A system includes a placement head with at least one printing nozzle configured to pick up and detachably hold at least one biological organism; an image acquisition system including a visual inspection system configured to identify at least one target biological organism to be picked up by the printing nozzle of the placement head in a first location, and identify at least one second location for deposit of the at least one target biological organism, wherein the first location is different from the at least one second location; and a robotic motion system that moves the placement head, based on input from the visual inspection system and a distance identification system, from the first location to the at least one second location, such that the placement head deposits the target biological organism at the at least one second location. |
| FILED | Wednesday, July 20, 2022 |
| APPL NO | 17/813779 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/209 (20170801) B29C 64/393 (20170801) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 50/02 (20141201) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0062 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230025438 | Najafi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Louisiana at Lafayette (Lafayette, Louisiana) |
| ASSIGNEE(S) | University of Louisiana at Lafayette (Lafayette, Louisiana) |
| INVENTOR(S) | Mohammadhassan Najafi (Lafayette, Louisiana); Mohsen Imani (Irvine, California); Sina Asadi (Lafayette, Louisiana) |
| ABSTRACT | Disclosed herein is a low-cost finite state machine-based low-discrepancy bit-stream generator that support generation of any number of independent low-discrepancy bit-streams. Here, the order of bit selection by the FSM of the bit-stream generator is determined based on the distribution of numbers in the Sobol sequences. An independent LD bit-stream is generated by setting up the FSM using a different Sobol sequence. The proposed generator reduces the hardware costs by more than 80 percent compared to the low-discrepancy bit-stream generators known in the art. The available space can then be used to improve fault tolerance. |
| FILED | Friday, July 15, 2022 |
| APPL NO | 17/866299 |
| CURRENT CPC | Electric Digital Data Processing G06F 7/74 (20130101) Original (OR) Class G06F 17/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230025651 | Leo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sin Yen Leo (Gainesville, Florida); Peng Jiang (Gainesville, Florida); Tianwei Xie (Gainesville, Florida) |
| ABSTRACT | Embodiments of the present disclosure provide for methods of detecting, sensors (e.g., chromogenic sensor), kits, compositions, and the like that related to or use tunable macroporous polymer. In an aspect, tunable macroporous materials as described herein can be used to determine the presence of a certain type(s) and quantity of liquid in a liquid mixture. |
| FILED | Tuesday, September 06, 2022 |
| APPL NO | 17/903312 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/81 (20130101) C08G 18/6755 (20130101) C08G 2101/00 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 9/26 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/25 (20130101) G01N 21/78 (20130101) Original (OR) Class G01N 21/255 (20130101) G01N 21/272 (20130101) G01N 33/2852 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230025974 | Yang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY (Hoboken, New Jersey) |
| ASSIGNEE(S) | THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY (Hoboken, New Jersey) |
| INVENTOR(S) | Eui-Hyeok Yang (Fort Lee, New Jersey); Jian Xu (West Lafayette, Indiana); Wei Xu (Farmingdale, New York); Brendan Englot (New York, New York); Chang-Hwan Choi (Tenafly, New Jersey) |
| ABSTRACT | Smart membranes (14) are integrated into a small, unmanned surface vessel (20) to enable the efficient, automated cleanup of oil spills. Such a vessel (20) has the potential to provide a low-cost, modular solution for day-to-day oil-spill cleanup operations, especially in confined aquatic areas, such as under piers and in the small spaces between marine vessels and piers. The smart membranes (14) are provided on the surface of a conveyor belt (34) that circulates the membranes (14) through the surrounding body of water (10) for oil collection, as well as through an internal reduction chamber (22) of the vessel (20) for oil release. The smart membranes (14) are adapted to attract and repel oil (12) in response to low-voltage commands applied across the conveyor belt (34), using a process that is repeatable for a number of cycles, offering high efficiency and long durability (FIG. 5). |
| FILED | Thursday, August 04, 2022 |
| APPL NO | 17/881406 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/40 (20130101) Original (OR) Class C02F 1/285 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230026670 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (Blacksburg, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jian Liu (Blacksburg, Virginia); Dong Dong (Blacksburg, Virginia); Rolando Burgos (Blacksburg, Virginia) |
| ABSTRACT | Aspects are described for hybrid modular multilevel converters that include half-bridge submodules. In some embodiments, a hybrid modular multilevel converter can include a direct current (DC) bus and an alternating current (AC) node. A first arm of the hybrid modular multilevel converter includes a first submodule chain link and a first arm inductor and a second arm includes a second submodule chain link and a second arm inductor. A capacitor connects between a first side of the first arm and a first side of the second arm. |
| FILED | Monday, July 19, 2021 |
| APPL NO | 17/378941 |
| CURRENT CPC | Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/36 (20130101) Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/0095 (20210501) H02M 7/4837 (20210501) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230027017 | Sirkar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | New Jersey Institute of Technology (Newark, New Jersey) |
| ASSIGNEE(S) | New Jersey Institute of Technology (Newark, New Jersey) |
| INVENTOR(S) | Kamalesh Sirkar (Bridgewater, New Jersey); Lydia Rodrigues (Linden, New Jersey) |
| ABSTRACT | An example porous composite membrane for solvent extraction is provided. The porous composite membrane includes a Janus membrane with a first side and a second side opposing the first side. The first side exhibits hydrophobic characteristics and the second side exhibits hydrophilic characteristics. At least one of the first side or the second side is sized to perform nondispersive membrane solvent extraction. |
| FILED | Tuesday, July 05, 2022 |
| APPL NO | 17/857580 |
| CURRENT CPC | Separation B01D 11/0415 (20130101) B01D 61/246 (20130101) Original (OR) Class B01D 67/0088 (20130101) B01D 69/02 (20130101) B01D 69/06 (20130101) B01D 69/08 (20130101) B01D 69/12 (20130101) B01D 69/1218 (20220801) B01D 71/34 (20130101) B01D 71/36 (20130101) B01D 71/56 (20130101) B01D 71/262 (20220801) B01D 71/5222 (20220801) B01D 2323/02 (20130101) B01D 2323/04 (20130101) B01D 2325/022 (20130101) B01D 2325/36 (20130101) B01D 2325/38 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230027270 | RUBENSTEIN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Brown University (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brenda RUBENSTEIN (Providence, Rhode Island); Jacob Karl ROSENSTEIN (Providence, Rhode Island); Christopher ARCADIA (Providence, Rhode Island); Shui Ling CHEN (Harrisburg, Pennsylvania); Amanda Doris DOMBROSKI (Cranston, Rhode Island); Joseph D. GEISER (Barrington, Rhode Island); Eamonn KENNEDY (West Warwick, Rhode Island); Eunsuk KIM (Providence, Rhode Island); Kady M. OAKLEY (North Attleboro, Massachusetts); Sherief REDA (Barrington, Rhode Island); Christopher ROSE (Providence, Rhode Island); Jason Kelby SELLO (Tiverton, Rhode Island); Hokchhay TANN (Providence, Rhode Island); Peter WEBER (Barrington, Rhode Island); Dana Jo Biechele-Speziale (North Providence, Rhode Island); Selahaddin GUMUS (North Providence, Rhode Island) |
| ABSTRACT | The invention provides methods for computing with chemicals by encoding digital data into a plurality of chemicals to obtain a dataset; translating the dataset into a chemical form; reading the data set; querying the dataset by performing an operation to obtain a perceptron; and analyzing the perceptron for identifying chemical structure and/or concentration of at least one of the chemicals, thereby developing a chemical computational language. The invention demonstrates a workflow for representing abstract data in synthetic metabolomes. Also presented are several demonstrations of kilobyte-scale image data sets stored in synthetic metabolomes, recovered at >99% accuracy. |
| FILED | Thursday, September 01, 2022 |
| APPL NO | 17/929279 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 99/007 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230027415 | Ma et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Florida State University Research Foundation, Inc. (Tallahassee, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Biwu Ma (Tallahassee, Florida); Qingquan He (Tallahassee, Florida) |
| ABSTRACT | Methods of passivating surfaces, composite materials, and electronic devices including the composite materials. The composite materials can include a passivated film, such as a metal halide perovskite passivated with an organic dye. The electronic devices may include solar cells. |
| FILED | Wednesday, March 02, 2022 |
| APPL NO | 17/684991 |
| CURRENT CPC | Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 9/0036 (20130101) H01G 9/2009 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0068 (20130101) H01L 51/0071 (20130101) H01L 51/0072 (20130101) H01L 51/0077 (20130101) H01L 51/448 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230028346 | Arnold et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Scott Arnold (Middleton, Wisconsin); Katherine Rose Jinkins (Evanston, Illinois); Padma Gopalan (Madison, Wisconsin) |
| ABSTRACT | Methods of forming films of aligned carbon nanotubes on a substrate surface are provided. The films are deposited from carbon nanotubes that have been concentrated and confined at a two-dimensional liquid/liquid interface. The liquid/liquid interface is formed by a dispersion of organic material-coated carbon nanotubes that flows over the surface of an immiscible liquid within a flow channel. Within the interface, the carbon nanotubes self-organize via liquid crystal phenomena and globally align along the liquid flow direction. By translating the interface across the substrate, large-area, wafer-scale films of aligned carbon nanotubes can be deposited on the surface of the substrate in a continuous and scalable process. |
| FILED | Thursday, July 15, 2021 |
| APPL NO | 17/376295 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0003 (20130101) H01L 51/0012 (20130101) Original (OR) Class H01L 51/0048 (20130101) H01L 51/0545 (20130101) H01L 51/0558 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230028442 | SHOLL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas R. SHOLL (Gainesville, Florida); Kamran MOHSENI (Gainesville, Florida) |
| ABSTRACT | A soft structure fiber reinforcement and actuation technology is provided. In an example embodiment, the tendon-driven, fiber-reinforced elastomer membrane comprises an elastomer matrix material and a fiber array embedded within the elastomer matrix material. The one or more tendons are not mechanically bonded to the elastomer matrix material, such that the one or more embedded tendons are able to move through the elastomer matrix material. One or more apparatuses may employ one or more such tendon-driven, fiber-reinforced elastomer membranes for use in a variety of applications. |
| FILED | Friday, May 20, 2022 |
| APPL NO | 17/664237 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/142 (20130101) B25J 9/1075 (20130101) Original (OR) Class Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/046 (20130101) C08J 2383/04 (20130101) C08J 2423/28 (20130101) C08J 2427/12 (20130101) C08J 2427/16 (20130101) C08J 2471/10 (20130101) C08J 2477/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230029257 | KISHI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Jocelyn KISHI (Boston, Massachusetts); Ninning LIU (Boston, Massachusetts); Sinem SAKA (Allston, Massachusetts); Peng YIN (Brookline, Massachusetts); Kuanwei SHENG (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein are compositions, kits, and methods for nucleic acid barcoding. The barcode compositions provided herein can be used to linearly, combinatorially, or spatially barcode a plurality of targets in a sample. Also provided herein is a device for use in a barcoding method provided herein comprising a light source and a sample holder. |
| FILED | Friday, December 11, 2020 |
| APPL NO | 17/783750 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6818 (20130101) Original (OR) Class C12Q 1/6841 (20130101) C12Q 2600/16 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230029277 | Shea et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Yoshiko Miura (Fukuoka, Japan); Yu Hoshino (Fukuoka, Japan); Yuri Nishimura (Fukuoka, Japan); Naoto Oku (Shizuoka, Japan); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenneth J. Shea (Irvine, California); Hiroyuki Koide (Shizuoka City, Japan); Yoshiko Miura (Fukuoka, Japan); Yu Hoshino (Fukuoka, Japan); Yuri Nishimura (Fukuoka, Japan); Naoto Oku (Shizuoka, Japan) |
| ABSTRACT | The present invention relates generally to compositions and methods comprising abiotic, synthetic polymers with affinity and specificity to proteins. The synthetic polymers are an improvement over biological agents by providing a simpler, less expensive, and customizable platform for binding to proteins. In one embodiment, the compositions and methods relate to synthetic polymers with affinity and specificity to vascular endothelial growth factor (VEGF). In one embodiment, the compositions are useful for treating diseases and disorders related to the overexpression of VEGF. In one embodiment, the compositions are useful for treating cancer. In one embodiment, the compositions are useful for detecting VEGF levels from biological samples. In one embodiment, the compositions are useful for detecting overexpression of VEGF from biological samples. In one embodiment, the compositions are used to diagnose cancer. |
| FILED | Friday, September 23, 2022 |
| APPL NO | 17/934727 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/5146 (20130101) Original (OR) Class A61K 31/704 (20130101) A61K 31/785 (20130101) A61K 31/795 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230029405 | STEFANOPOULOU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (ANN ARBOR, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ANNA G. STEFANOPOULOU (ANN ARBOR, Michigan); ANDREW WENG (ANN ARBOR, Michigan); PEYMAN MOHTAT (ANN ARBOR, Michigan); PETER M. ATTIA (STANFORD, California); VALENTIN SULZER (ANN ARBOR, Michigan); SUHAK LEE (ANN ARBOR, Michigan); GREG LESS (ANN ARBOR, Michigan) |
| ABSTRACT | The present disclosure relates to a method for optimizing the formation protocol of a battery. The method can include the steps of: (a) providing a battery cell structure comprising an anode, an electrolyte, and a cathode including cations that move from the cathode to the anode during charging; (b) performing a first charge of the battery cell structure using a predetermined formation protocol to create a formed battery cell; and (c) determining a cell internal resistance of the formed battery cell. Therefore, one can compare the cell internal resistances of two battery cells formed by using identical battery cell structures and different formation protocols, and select a formation protocol if the first cell internal resistance of a first formed battery is greater than or less than the second cell internal resistance of a second formed battery. |
| FILED | Thursday, July 07, 2022 |
| APPL NO | 17/859390 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/367 (20190101) G01R 31/389 (20190101) Original (OR) Class G01R 31/396 (20190101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/48 (20130101) H01M 10/446 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20230022235 | Gao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California); Ohio State Innovation Foundation (Columbus, Ohio); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | Allen C. Gao (Davis, California); Pui-Kai Li (Columbus, Ohio); Enming Xing (Columbus, Ohio); Xiaolin Cheng (Columbus, Ohio); Xiaotian Kong (Columbus, Ohio); Wei Lou (Davis, California) |
| ABSTRACT | The present invention provides benzamide compounds, compositions containing the benzamides, and use of the benzamides for inhibiting androgen receptor (AR) and/or aldo-keto reductase family 1 member C3 (AKR1C3). Also described herein methods for the treatment of hormone-mediated diseases and conditions, including hormone-related cancers such as castration resistant prostate cancer. |
| FILED | Monday, May 16, 2022 |
| APPL NO | 17/745621 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 235/42 (20130101) C07C 235/64 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230022554 | Peterson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia); University of South Florida (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew J. Peterson (Tampa, Florida); Linda J. Cowan (Tampa, Florida); Kimberly S. Hall (Tampa, Florida); Dmitry Goldgof (Tampa, Florida); Sudeep Sarkar (Tampa, Florida); Chih-Yun Pai (Tampa, Florida); Hunter Morera (Tampa, Florida); Yu Sun (Tampa, Florida) |
| ABSTRACT | Methods and systems for imaging and analysis are described. Accurate pressure ulcer measurement is critical in assessing the effectiveness of treatment. However, the traditional measuring process is subjective. Each health care provider may measure the same wound differently, especially related to the depth of the wound. Even the same health care provider may obtain inconsistent measurements when measuring the same wound at different times. Also, the measuring process requires frequent contact with the wound, which increases risk of contamination or infection and can be uncomfortable for the patient. The present application describes a new automatic pressure ulcer monitoring system (PrUMS), which uses a tablet connected to a 3D scanner, to provide an objective, consistent, non-contact measurement method. The present disclosure combines color segmentation on 2D images and 3D surface gradients to automatically segment the wound region for advanced wound measurements. |
| FILED | Wednesday, October 14, 2020 |
| APPL NO | 17/768952 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0077 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 7/12 (20170101) G06T 7/62 (20170101) Original (OR) Class G06T 7/90 (20170101) G06T 2200/04 (20130101) G06T 2207/10024 (20130101) G06T 2207/20021 (20130101) G06T 2207/20081 (20130101) G06T 2207/30096 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230027192 | Bajaj |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jasmohan S. Bajaj (Richmond, Virginia) |
| ABSTRACT | Provided herein are solid dispersions comprising rifaximin and pharmaceutical compositions and uses thereof. |
| FILED | Tuesday, November 24, 2020 |
| APPL NO | 17/779865 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/284 (20130101) A61K 9/2009 (20130101) A61K 9/2013 (20130101) A61K 9/2031 (20130101) A61K 9/2054 (20130101) A61K 31/437 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/14 (20180101) A61P 1/16 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230027620 | AAKALU |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vinay Kumar AAKALU (Chicago, Illinois) |
| ABSTRACT | A synthetic peptide including the sequence SHXGY (SEQ ID NO:2) is described as are methods of using the same for promoting wound healing and epithelial cell migration. |
| FILED | Wednesday, November 25, 2020 |
| APPL NO | 17/778138 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1729 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/02 (20180101) A61P 27/02 (20180101) A61P 31/04 (20180101) Peptides C07K 14/4723 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20230023038 | Rizvi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Syed S.H. Rizvi (Ithaca, New York); Apratim Jash (Ithaca, New York); Ali Ubeyitogullari (Fayetteville, Arkansas) |
| ABSTRACT | Milk fat globule membrane (MFGM) phospholipid compositions, methods of preparing and using the MFGM phospholipid compositions, liposomes comprising the MFGM phospholipid compositions, and methods of preparing and using the liposomes comprising the MFGM phospholipid compositions. In various examples, a MFGM phospholipid composition is formed by sequential supercritical carbon dioxide (SC—CO2) extraction of a milk product and extraction of the remaining milk product with a polar compound-modified SC—CO2 extraction, where the extract is the MFGM. In various examples, the MFGM is used to prepare liposomes. In various examples, the liposomes are prepared by expansion of a supercritical solution comprising the MFGM composition. In various examples, the liposomes are used to administer a cargo, such as, for example, hydrophilic compound(s), hydrophobic compound(s), amphiphilic compound(s), or the like, any one or all of which may be therapeutic agent(s), nutrient(s), bioagent(s), or the like, or any combination thereof to a subject. |
| FILED | Monday, July 11, 2022 |
| APPL NO | 17/862310 |
| CURRENT CPC | Protein Compositions for Foodstuffs; Working-up Proteins for Foodstuffs; Phosphatide Compositions for Foodstuffs A23J 1/205 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 8/14 (20130101) A61K 8/553 (20130101) A61K 9/1276 (20130101) Original (OR) Class A61K 9/1277 (20130101) A61K 47/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230023780 | Steen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | LYGOS, Inc. (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric Steen (Berkeley, California); Jeffrey Dietrich (Berkeley, California); Johan Van Walsem (Berkeley, California) |
| ABSTRACT | A process for the preparation of bio-based malonic acid and crystalline calcium malonate is provided. The calcium malonate is highly pure and provides a source of malonic acid made from a renewable carbon source rather than existing processes which rely on the use of petroleum-based products. The calcium malonate provides an improved source of malonic acid, which is important to many industrial processes. |
| FILED | Thursday, April 07, 2022 |
| APPL NO | 17/658406 |
| CURRENT CPC | General Methods of Organic Chemistry; Apparatus Therefor C07B 63/02 (20130101) C07B 2200/13 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/02 (20130101) C12N 1/16 (20130101) C12N 1/165 (20210501) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/46 (20130101) Original (OR) Class Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/84 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230024886 | Wu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Matthew Allen Zolnowsky (Rapid City, South Dakota); THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (Washington, District of Columbia) |
| ASSIGNEE(S) | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (Washington, District of Columbia) |
| INVENTOR(S) | Samuel Tze-Han Wu (Monrovia, California); Matthew Allen Zolnowsky (Rapid City, South Dakota) |
| ABSTRACT | The fish screen for a suction strainer includes at least one first plate having a central opening formed therethrough, a second plate, a helical spring, and a mesh bag. The helical spring has opposed first and second ends, with the first end secured to the at least one first plate and the second end secured to the second plate. The helical spring has first and second portions positioned respectively adjacent to the first and second ends. The second portion has a smaller diameter than a diameter of the first portion. The mesh bag releasably and removably covers and receives the at least one first plate, the second plate and the helical spring. The second portion of the helical spring is adapted for releasably holding a free end of a suction strainer received within an interior of the helical spring through the central opening of the at least one first plate. |
| FILED | Thursday, July 07, 2022 |
| APPL NO | 17/859051 |
| CURRENT CPC | Hydraulic Engineering E02B 1/006 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20230022693 | Facchetti et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois); Flexterra, Inc. (Skokie, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Antonio F. Facchetti (Chicago, Illinois); Tobin J. Marks (Evanston, Illinois); Wei Huang (Deyang, China PRC); Jianhua Chen (Shenzhen, China PRC); Yu Xia (Northbrook, Illinois) |
| ABSTRACT | Photocurable compositions that combine redox-active semiconducting organic polymers with photocurable organic molecules are provided. Upon exposure to radiation, the photocurable compositions form ion-permeable, electrically conductive crosslinked organic films that can be used as conducting channels in n-channel or p-channel organic electrochemical transistors, including vertical organic electrochemical transistors (vOECTs). The vOECTs can be incorporated in complementary electronic circuits. |
| FILED | Tuesday, July 05, 2022 |
| APPL NO | 17/857596 |
| CURRENT CPC | Compositions of Macromolecular Compounds C08L 65/00 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/24 (20130101) C09D 165/00 (20130101) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 9/22 (20130101) H01G 9/26 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/283 (20130101) H01L 51/0036 (20130101) Original (OR) Class H01L 51/0043 (20130101) H01L 51/0566 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20230022988 | Hastings et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | William Hastings (Alexandria, Virginia); Kevin Gemp (Falls Church, Virginia); Elyssa Kaplan (Middleton, Massachusetts); Kevin Dickey (Arlington, Virginia); Daniel Sims (McLean, Virginia) |
| ABSTRACT | In an example, a thermal imaging test article comprises a block configured to be attached to a blackbody on a back side of the block, the block having a variable thickness to represent facial features of a human face, the block including a cutout to allow a thermal imaging device to see the blackbody behind the block through the cutout, and one or more heaters thermally coupled to the block to produce heat to heat the block. The variable thickness of the block and the heat produced by the one or more heaters are selected to simulate thermally the human face on a front side of the block. |
| FILED | Tuesday, July 12, 2022 |
| APPL NO | 17/863112 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 5/10 (20130101) G01J 5/53 (20220101) Original (OR) Class G01J 5/80 (20220101) G01J 5/485 (20220101) G01J 2005/0077 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 20230024822 | Ahmed et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sara Ahmed (San Antonio, Texas); Mohamadreza Khalili (Austin, Texas); Athanassios Thomas Pagagiannakis (Austin, Texas); Gopal Vishwakarma (Austin, Texas); Samer Dessouky (Helotes, Texas) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Sara Ahmed (San Antonio, Texas); Mohamadreza Khalili (Austin, Texas); Athanassios Thomas Pagagiannakis (Austin, Texas); Gopal Vishwakarma (Austin, Texas); Samer Dessouky (Helotes, Texas) |
| ABSTRACT | Aspects of self-powered weigh-in-motion systems and methods that utilize piezoelectric components for sensing load as well as powering data acquisition and analysis components. In one example, the weigh-in-motion system includes a number of piezoelectric stacks, each stack including a number of piezoelectric elements. Each stack includes one or more top or upper piezoelectric element that provides vehicle sensing data. Each stack also includes a set of piezoelectric elements used for energy harvesting. The sensing piezoelectric elements are connected to a data input of a microcontroller for vehicle classification, while the energy harvesting piezoelectric elements are connected to a power input of the microcontroller. |
| FILED | Thursday, July 07, 2022 |
| APPL NO | 17/859429 |
| CURRENT CPC | Weighing G01G 3/13 (20130101) G01G 19/035 (20130101) Original (OR) Class G01G 19/52 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 41/083 (20130101) H01L 41/1132 (20130101) Electric Machines Not Otherwise Provided for H02N 2/181 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20230027356 | Chattopadhyay et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Goutam Chattopadhyay (Pasadena, California); Robert H. Lin (Chino, California); Sven L. Van Berkel (Pasadena, California); Sofia Rahiminejad (Pasadena, California) |
| ABSTRACT | Low-loss terahertz switches with nanometer resolution positioning and feedback are disclosed. In one embodiment, the switch uses a U-bend waveguide surrounded by an electromagnetic band gap and is implemented in a fully metal-machined fashion in combination with a piezo-electric motor and an optical linear encoder. In another embodiment, the switch comprises a MEMS device. |
| FILED | Tuesday, June 21, 2022 |
| APPL NO | 17/845762 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/3578 (20130101) Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 1/02 (20130101) H01P 1/122 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Non-Profit Organization (NPO)
| US 20230027890 | Zhao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | University of Southern California (Los Angeles, California) |
| INVENTOR(S) | Yajie Zhao (Los Angeles, California); Jing Yang (Los Angeles, California); Hanyuan Xiao (Los Angeles, California) |
| ABSTRACT | Methods and systems are provided for rendering photo-realistic images of a subject or an object using a differentiable neural network for predicting indirect light behavior. In one example, the differentiable neural network outputs a volumetric light map comprising a plurality of spherical harmonic representations. Further, using a reflectance neural network, roughness and scattering coefficients associated with the subject or the object is computed. The volumetric light map, as well as the roughness and scattering coefficients are the utilized for rendering a final image under one or more of a desired lighting condition, desired camera view angle, and/or with a desired visual effect (e.g., expression change). |
| FILED | Tuesday, May 03, 2022 |
| APPL NO | 17/735869 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 15/04 (20130101) G06T 15/10 (20130101) G06T 15/80 (20130101) G06T 15/506 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
U.S. Agency for International Development (USAID)
| US 20230027965 | Chan-Hui et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THERACLONE SCIENCES, INC. (Seattle, Washington); THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California); INTERNATIONAL AIDS VACCINE INITIATIVE (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Po-Ying Chan-Hui (Bellevue, Washington); Katherine Doores (San Diego, California); Michael Huber (Zurich, Switzerland); Stephen Kaminsky (Bronx, New York); Steven Frey (Redmond, Washington); Ole Olsen (Everett, Washington); Jennifer Mitcham (Redmond, Washington); Matthew Moyle (Redmond, Washington); Sanjay K. Phogat (Frederick, Maryland); Dennis R. Burton (La Jolla, California); Laura Majorie Walker (San Diego, California); Pascal Raymond Georges Poignard (San Diego, California); Wayne Koff (Stony Brook, New York); Melissa Danielle De Jean De St. Marcel Simek-Lemos (Brooklyn, New York) |
| ABSTRACT | The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided. |
| FILED | Thursday, July 15, 2021 |
| APPL NO | 17/376276 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/21 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Peptides C07K 16/1045 (20130101) C07K 16/1063 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, January 26, 2023.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20230126.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page