FedInvent™ Patent Applications
Application Details for Thursday, February 02, 2023
This page was updated on Friday, February 03, 2023 at 12:37 PM GMT
Department of Health and Human Services (HHS)
| US 20230029506 | CONG et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Le CONG (Cambridge, Massachusetts); David Benjamin Turitz COX (Cambridge, Massachusetts); Matthias HEIDENREICH (Cambridge, Massachusetts); Randall Jeffrey PLATT (Cambridge, Massachusetts); Lukasz SWIECH (Cambridge, Massachusetts); Feng ZHANG (Cambridge, Massachusetts) |
| ABSTRACT | The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition. |
| FILED | Friday, June 03, 2022 |
| APPL NO | 17/831745 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 38/465 (20130101) A61K 48/00 (20130101) A61K 48/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/102 (20130101) C12N 15/907 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230029557 | PINKERTON et al. |
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| FUNDED BY |
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| APPLICANT(S) | Sanford Burnham Prebys Medical Discovery Institute (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anthony B. PINKERTON (Rancho Santa Fe, California); Robert J. ARDECKY (Encinitas, California); Jiwen ZOU (San Diego, California) |
| ABSTRACT | Protein tyrosine phosphatases (PTPs) are key regulators of metabolism and insulin signaling. As a negative regulator of insulin signaling, the low molecular weight protein tyrosine phosphatase (LMPTP) is a target for insulin resistance and related conditions. Described herein are compounds capable of modulating the level of activity of low molecular weight protein tyrosine phosphatase (LMPTP) and compositions, and methods of using these compounds and compositions. |
| FILED | Tuesday, June 08, 2021 |
| APPL NO | 17/342226 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/04 (20180101) Heterocyclic Compounds C07D 519/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230029635 | Wiestner et al. |
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| FUNDED BY |
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| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland); The Scripps Research Institute (La Jolla, California) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland); The Scripps Research Institute (La Jolla, California) |
| INVENTOR(S) | Adrian Wiestner (Bethesda, Maryland); Christoph Rader (Jupiter, Florida); Haiyong Peng (Jupiter, Florida); Sivasubramanian Baskar (Ellicott City, Maryland); Erika Gaglione (Germantown, Maryland) |
| ABSTRACT | Disclosed are anti-C3d antibodies or fragments thereof. Also disclosed are methods of killing cancer cells, methods of preparing anti-C3d antibodies, and pharmaceutical compositions. |
| FILED | Tuesday, December 08, 2020 |
| APPL NO | 17/783345 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2896 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230030032 | Joo et al. |
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| FUNDED BY |
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| APPLICANT(S) | Aggamin, LLC (New Yoek, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Woo S. Joo (Gaithersburg, Maryland); Karen M. Lee (Massapequa, New York); Adelene Y. Tan (New York, New York); Garrett D. Daniels (Mamaroneck, New York); Paul Kussie (New York, New York) |
| ABSTRACT | Disclosed are methods and apparatuses for treating a pregnancy related hypertensive disorder, such as pre-eclampsia and eclampsia, using ex vivo treatment with an anti-sEng antibody bound to a solid support in order to reduce blood levels of sEng. The present invention provides a method of treating or preventing a disorder associated with soluble Endoglin (sEng), such as a pregnancy-related hypertensive disorder, in a subject in need thereof comprising providing ex vivo to the subject anti-sEng antibodies or sEng-binding fragments thereof in an amount sufficient and for a time sufficient to decrease the subject's blood levels of sEng to treat or prevent the disorder associated with sEng in the subject. |
| FILED | Tuesday, December 08, 2020 |
| APPL NO | 17/783783 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/14 (20180101) Peptides C07K 16/2896 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/92 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2015/8518 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/689 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230030517 | BISSERIER et al. |
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| FUNDED BY |
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| APPLICANT(S) | INSERM (Institut National de la Santé et de la Recherche Médicale) (Paris, France); Université Paul Sabatier Toulouse III (Toulouse Cedex 9, France); Icahn School of Medicine at Mount Sinai (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Malik BISSERIER (New York, New York); Frank LEZOUALC'H (Toulouse Cedex 04, France); Lahouaria HADRI (New York, New York) |
| ABSTRACT | The present invention relates to the treatment of idiopathic pulmonary fibrosis. Today, there is no cure for IFF. The inventors showed that EPAC1 inhibitors, in particular CE3F4 and AM-001, represent a promising therapeutic strategy for treating patients with pulmonary fibrosis. The present invention thus relates to an EPAC1 inhibitor for use in the treatment and/or prevention of idiopathic pulmonary fibrosis. |
| FILED | Friday, December 11, 2020 |
| APPL NO | 17/783928 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/47 (20130101) A61K 31/4365 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230030773 | Wilkinson et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
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| INVENTOR(S) | Adam C. Wilkinson (Redwood City, California); Hiromitsu Nakauchi (Woodside, California); Yamazaki Satoshi (Tokyo, Japan); Kyle M. Loh (Stanford, California); Toshinobu Nishimura (Redwood City, California) |
| ABSTRACT | Serum albumin-free media comprising polyvinyl alcohol (PVA) and methods of culturing immune cells in such media are disclosed. The PVA is used as a replacement for fetal bovine serum, bovine serum albumin, and recombinant serum albumin in media. Advantages of using PVA include that it is a chemically-defined reagent that is available at high-purity with minimal batch-to-batch variability. |
| FILED | Tuesday, December 15, 2020 |
| APPL NO | 17/783473 |
| CURRENT CPC | Peptides C07K 14/7051 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0037 (20130101) C12N 5/0636 (20130101) Original (OR) Class C12N 15/09 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230030998 | Kochenderfer |
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| FUNDED BY |
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| APPLICANT(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | James N. Kochenderfer (Bethesda, Maryland) |
| ABSTRACT | The invention provides an isolated and purified nucleic acid sequence encoding a chimeric antigen receptor (CAR) directed against B-cell Maturation Antigen (BCMA). The invention also provides host cells, such as T-cells or natural killer (NK) cells, expressing the CAR and methods for destroying multiple myeloma cells. |
| FILED | Thursday, October 06, 2022 |
| APPL NO | 17/938535 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Peptides C07K 14/7051 (20130101) C07K 14/70503 (20130101) C07K 14/70517 (20130101) C07K 14/70521 (20130101) C07K 14/70578 (20130101) C07K 16/18 (20130101) C07K 16/2878 (20130101) C07K 2317/73 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/62 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230031009 | Ehrlich et al. |
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| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (NEW HAVEN, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Barbara Ehrlich (New Haven, Connecticut); Lien Nguyen (Jamaica Plain, Massachusetts) |
| ABSTRACT | The present invention is directed to a method of treatment, including prevention or reducing the likelihood of adverse effects of chemotherapy comprising reducing and/or inhibiting chemotherapy-induced adverse effects (CIAE), especially central nervous system adverse effects, such as cognitive effects (especially chemotherapy induced cognitive impairment or CICI, also referred to as reduced cognition, cognitive impairment or chemobrain) by administering to the patient in need, including co-administering to the subject in need a pharmaceutically effective amount of a protein kinase C (PKC, often, PKC α and/or β) inhibitor, alone or in combination with a lithium salt. Related pharmaceutical compositions are also provided by the present invention. |
| FILED | Thursday, February 11, 2021 |
| APPL NO | 17/801486 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/337 (20130101) A61K 31/437 (20130101) A61K 31/675 (20130101) A61K 31/704 (20130101) A61K 31/4741 (20130101) Original (OR) Class A61K 33/14 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230031287 | Penaloza-MacMaster et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pablo Penaloza-MacMaster (Oak Park, Illinois); Nicole Palacio (Evanston, Illinois) |
| ABSTRACT | Disclosed herein are methods, compositions, and kits useful to enhance an immune response against an antigen and to improve vaccine efficacy. The disclosed methods, compositions, and kits may be utilized to improve vaccine immunogenicity and enhance immune protection following subsequent antigen challenges. In some embodiments, the methods include co-administering a blocker of the IFN-I pathway with an antigen that is used as part of a vaccine, such as a viral vaccine. |
| FILED | Monday, December 14, 2020 |
| APPL NO | 17/784891 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/13 (20130101) A61K 39/20 (20130101) A61K 39/21 (20130101) A61K 39/25 (20130101) A61K 39/29 (20130101) A61K 39/145 (20130101) A61K 39/165 (20130101) A61K 39/205 (20130101) A61K 39/275 (20130101) A61K 39/292 (20130101) A61K 39/3955 (20130101) Original (OR) Class A61K 2039/5256 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) A61P 31/16 (20180101) A61P 31/18 (20180101) A61P 31/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230031593 | HIELSCHER et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| INVENTOR(S) | Andreas H. HIELSCHER (Brooklyn, New York); Christopher J. FONG (New York, New York); Jennifer HOI (Belmont, California); Hyun K. KIM (Cresskill, New Jersey); Michael KHALIL (Miami Lake, Florida) |
| ABSTRACT | A plurality of modules are simultaneously positioned at locations that correspond to different angiosomes. Each of these modules has a front surface shaped and dimensioned for contacting a person's skin, a plurality of different-wavelength light sources aimed in a forward direction, and a plurality of light detectors aimed to detect light arriving from in front of the front surface. Each module is supported by a support structure (e.g., a strap or a clip) that is shaped and dimensioned to hold the front surface adjacent to the person's skin at a respective position. Perfusion in each of the angiosomes is monitored using these modules, and the surgeon can rely on this information to guide his or her intervention. |
| FILED | Friday, August 05, 2022 |
| APPL NO | 17/881844 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/00 (20130101) A61B 5/02 (20130101) A61B 5/021 (20130101) A61B 5/022 (20130101) A61B 5/24 (20210101) A61B 5/0073 (20130101) A61B 5/0075 (20130101) A61B 5/0245 (20130101) A61B 5/0261 (20130101) Original (OR) Class A61B 5/1455 (20130101) A61B 5/02007 (20130101) A61B 5/02255 (20130101) A61B 5/6828 (20130101) A61B 5/6829 (20130101) A61B 5/6831 (20130101) A61B 5/6884 (20130101) A61B 5/7425 (20130101) A61B 2560/0437 (20130101) A61B 2562/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230031708 | St-Pierre et al. |
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| FUNDED BY |
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| APPLICANT(S) | Baylor College of Medicine (Houston, Texas); William Marsh Rice University (Houston, Texas) |
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| INVENTOR(S) | François St-Pierre (Houston, Texas); Jihwan Lee (Houston, Texas); Zhuohe Liu (Houston, Texas); Peter Suzuki (Houston, Texas) |
| ABSTRACT | Provided herein are embodiments of methods and systems for screening cellular, subcellular, and multicellular structures. In one embodiment, a method for screening is provided comprising the steps of introducing a plurality of cellular, subcellular, or multicellular structures, or a combination thereof, to an imaging system, wherein one or more structures of the plurality comprise one or more taggable markers; imaging the plurality of structures using the imaging system; identifying one or more target structures among the plurality of structures based on one or more properties of the target structures; tagging the target structures to produce tagged target structures, wherein each target structure is selectively illuminated by an excitation light, thereby causing one or more taggable markers within the target structure to be phototransformed to produce one or more phototransformed taggable markers within the target structure; and isolating one or more tagged target structures from the plurality of structures. |
| FILED | Monday, January 25, 2021 |
| APPL NO | 17/759357 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/0227 (20130101) G01N 15/1456 (20130101) G01N 15/1468 (20130101) G01N 21/6458 (20130101) Original (OR) Class G01N 2015/149 (20130101) G01N 2015/0294 (20130101) G01N 2015/1493 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20230031853 — COMPOSITIONS AND METHODS FOR THE CYTOPLASMIC DELIVERY OF ANTIBODIES AND OTHER PROTEINS
| US 20230031853 | TSOURKAS et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Andrew TSOURKAS (Bryn Mawr, Pennsylvania); Hejia Henry WANG (Philadelphia, Pennsylvania) |
| ABSTRACT | The invention provides compositions and methods for the cytoplasmic delivery of antibodies and other proteins. Specifically, provided herein are compositions having an anionic polypeptide and a cationic transfection agent for facilitating the cytoplasmic delivery of an antibody or a protein. |
| FILED | Thursday, November 14, 2019 |
| APPL NO | 17/294401 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5123 (20130101) A61K 47/65 (20170801) A61K 47/6455 (20170801) A61K 47/6807 (20170801) Original (OR) Class A61K 47/6849 (20170801) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/18 (20130101) C07K 16/32 (20130101) C07K 16/40 (20130101) C07K 2317/31 (20130101) C07K 2317/76 (20130101) C07K 2317/77 (20130101) C07K 2317/569 (20130101) C07K 2317/622 (20130101) C07K 2319/30 (20130101) C07K 2319/33 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230031927 | Boehme et al. |
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| FUNDED BY |
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| APPLICANT(S) | PowerTech Water, Inc. (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lindsay Boehme (Iowa City, Iowa); Cameron Lippert (Lexington, Kentucky); James Richardson Landon (Lexington, Kentucky); Alan Rassoolkhani (Lexington, Kentucky); Jeffrey Rentschler (Lexington, Kentucky) |
| ABSTRACT | The present invention is directed to an electrochemical device for at least partially removing or reducing a target ionic species from an aqueous solution using faradic immobilization, the electrochemical device including at least one first electrode and at least one second electrode with different void fraction and surface area properties, due to differences in void fraction (also referred to as void ratio) of the at least one first and the at least one second electrode, water flows through an electrode with a high porosity, while the aqueous solution does not flow through an electrode with a low porosity. The asymmetry of the electrodes provides a desired voltage distribution across the device, which equates to a different voltage at each electrode, to control the speciation of the target ionic species at the anode and the cathode. |
| FILED | Thursday, September 15, 2022 |
| APPL NO | 17/932488 |
| CURRENT CPC | Separation B01D 61/485 (20130101) Original (OR) Class B01D 71/021 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/46109 (20130101) C02F 2101/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230032020 | MEROUEH et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Samy MEROUEH (Carmel, Indiana); Khuchtumur BUM-ERDENE (Indianapolis, Indiana); Giovanni GONZALEZ-GUTIERREZ (Bloomington, Indiana) |
| ABSTRACT | Disclosed herein are Ral-antagonist compounds that covalently bind to binding sites in RalA, and efficaciously inhibit Ral activity. The compounds include aryl sulfonyl fluoride compounds of the general structure of wherein X and Y are independently C or N, and R4 is C1-C4 alkyl, —OCH3, —OCH2CH3, —OCH(CH3)2, —(SO2)CH3, —OH, or halo. These compounds expand Ral-inhibiting therapeutic options for treating Ral-driven cancers and one embodiment of the present disclosure is directed to the use of such compounds to treat cancer. |
| FILED | Friday, December 18, 2020 |
| APPL NO | 17/782870 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/357 (20130101) Original (OR) Class A61K 31/4184 (20130101) A61K 31/4412 (20130101) A61K 31/4433 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230032060 | QUIJANO et al. |
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| FUNDED BY |
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| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | Yale University (New Haven, Connecticut) |
| INVENTOR(S) | Elias QUIJANO (Durham, Connecticut); Peter GLAZER (Guilford, Connecticut) |
| ABSTRACT | Compositions and methods of use thereof for delivering nucleic acid cargo into cells are provided. The compositions typically include (a) a 3E10 monoclonal antibody or an antigen binding, cell-penetrating fragment thereof; a monovalent, divalent, or multivalent single chain variable fragment (scFv); or a diabody; or humanized form or variant thereof, and (b) a nucleic acid cargo including, for example, a nucleic acid encoding a polypeptide, a functional nucleic acid, a nucleic acid encoding a functional nucleic acid, or a combination thereof. Elements (a) and (b) are typically non-covalently linked to form a complex. |
| FILED | Tuesday, August 30, 2022 |
| APPL NO | 17/823492 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/549 (20170801) Original (OR) Class A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/44 (20130101) C07K 2317/565 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1135 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230032136 | LANDER et al. |
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| FUNDED BY |
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| APPLICANT(S) | Suhas RAO (Houston, Texas); Andreas GNIRKE (Cambridge, Massachusetts); Saul GODINEZ (Houston, Texas); Huiya GU (Houston, Texas); Elena STAMENOVA (Cambridge, Massachusetts); THE BROAD INSTITUTE, INC. (CAMBRIDGE, Massachusetts); BAYLOR COLLEGE OF MEDICINE (HOUSTON, Massachusetts); THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric S. LANDER (Cambridge, Massachusetts); Erez AIDEN (Houston, Texas); Huiya GU (Houston, Texas); Saul GODINEZ PULIDO (Houston, Texas); Suhas RAO (Stanford, California); Elena STAMENOVA (Cambridge, Massachusetts); Namita MITRA (Houston, Texas) |
| ABSTRACT | Disclosed are methods for detecting spatial proximity relationships between nucleic acid sequences, such as genomic DNA, in a cell. The method includes providing a sample of one or more crosslinked cells comprising nucleic acids; permeabilizing isolated nuclei under conditions that preserve contacts; fragmenting the nucleic acids present in the nuclei; filling in and repairing the ends with at least one labeled nucleotide; joining the filled in end of the fragmented nucleic acids that are in close physical proximity to create one or more end joined nucleic acid fragments having a junction; isolating the one or more end joined nucleic acid fragments using the labeled nucleotide; and determining the sequence at the junction of the one or more end joined nucleic acid fragments. |
| FILED | Friday, December 11, 2020 |
| APPL NO | 17/785042 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6841 (20130101) Original (OR) Class C12Q 2521/301 (20130101) C12Q 2521/501 (20130101) C12Q 2523/101 (20130101) C12Q 2535/122 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230032239 | Termglinchan et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vittavat Termglinchan (Palo Alto, California); Ioannis Karakikes (Palo Alto, California); Joseph C. Wu (Stanford, California); Jaecheol Lee (Stanford, California); Sebastian Diecke (Berlin, Germany) |
| ABSTRACT | The present invention includes methods for treating and/or preventing dilated cardiomyopathy due to an LMNA mutation, comprised of administering to a subject at-risk a therapeutically effective amount of an inhibitor of PDGF signaling. |
| FILED | Wednesday, January 15, 2020 |
| APPL NO | 17/791110 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0056 (20130101) A61K 31/4709 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230032369 | OAKES et al. |
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| FUNDED BY |
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| APPLICANT(S) | Scribe Therapeutics, Inc. (Alameda, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin OAKES (El Cerrito, California); Sean HIGGINS (Alameda, California); Hannah SPINNER (Boston, Massachusetts); Sarah DENNY (San Francisco, California); Brett T. STAAHL (Tiburon, California); Kian TAYLOR (Atlanta, Georgia); Katherine BANEY (Berkeley, California); Isabel COLIN (Oakland, California); Maroof ADIL (Davis, California); Cole URNES (Los Angeles, California) |
| ABSTRACT | Provided herein are CRISPR:guide systems comprising Class 2 Type V polypeptides (e.g. CasX:gNA systems comprising CasX polypeptides), guide nucleic acids (gNA), and optionally donor template nucleic acids useful in the modification of a HTT gene. The systems are also useful for introduction into cells, for example eukaryotic cells having mutations in the huntingtin protein. Also provided are methods of using such systems to modify cells having such mutations and utility in methods of treatment of a subject with a HTT-related disease, such as Huntington's disease. |
| FILED | Tuesday, May 31, 2022 |
| APPL NO | 17/829206 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/86 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230032465 | St. Croix et al. |
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| FUNDED BY |
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| APPLICANT(S) | The U.S.A., as Represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Brad St. Croix (Frederick, Maryland); Yang Feng (Frederick, Maryland); Steven Seaman (Martinsburg, West Virginia) |
| ABSTRACT | An improved antibody-drug conjugate (ADC) targeting CD276-positive tumors is described. The ADC includes a CD276-specific IgG1 antibody having a heavy chain modified to prevent interaction of its Fc domain with endogenous Fc receptors and to introduce a cysteine for site-specific conjugation of the drug. The CD276-specific ADC is capable of potently eradicating CD276-positive tumors in several animal models. |
| FILED | Tuesday, December 08, 2020 |
| APPL NO | 17/783171 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6803 (20170801) A61K 47/6849 (20170801) A61K 47/6889 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2827 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230032532 | Zhao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yangbing Zhao (Lumberton, New Jersey); Jiangtao Ren (Philadelphia, Pennsylvania) |
| ABSTRACT | The present disclosure provides gene edited modified immune cells or precursors thereof (e.g., gene edited modified T cells) comprising an exogenous T cell receptor (TCR) and/or a chimeric antigen receptor (CAR) having specificity for a target antigen, and an insertion and/or deletion in one or more endogenous gene loci, wherein the endogenous gene loci encode regulators of T cell function, thereby resulting in immune cells having enhanced function. Compositions and methods of treatment are also provided. The present invention provides methods of screening for TCR- or CAR-T cells with enhanced immune function (e.g., T cell efficacy, T cell memory, and/or T cell persistence). |
| FILED | Thursday, May 12, 2022 |
| APPL NO | 17/743183 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 9/22 (20130101) C12N 15/11 (20130101) Original (OR) Class C12N 15/1082 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230032623 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NEW YORK UNIVERSITY (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Weiqiang Chen (New York, New York); Matija Snuderl (New York, New York); Chao Ma (New York, New York) |
| ABSTRACT | The present invention provides devices that replicate tumor microenvironments in a microfluidic chip. The devices can be used to model certain disease states related to tumor microenvironments. The devices can be adapted to replicate tumor microenvironments from patient-specific cells such that treatment conditions can be modeled and tailored to individual patients. In some embodiments, the devices are suitable for evaluating cancer therapies on a patient-specific basis. |
| FILED | Friday, July 29, 2022 |
| APPL NO | 17/816152 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) C12M 23/16 (20130101) C12M 23/42 (20130101) C12M 29/10 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5011 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230032847 | Ji et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hanlee P. Ji (Stanford, California); Billy Tsz Cheong Lau (Palo Alto, California) |
| ABSTRACT | Provided herein is a method for sample analysis. In some embodiments, the method may involve: (a) incubating a nucleic acid sample with a terminal transferase and a cyclooctene-functionalized nucleotide to produced cyclooctene-functionalized nucleic acid molecules; (b) tethering the cyclooctene-functionalized nucleic acid molecules to a tetrazine-functionalized support via an Alder cycloaddition reaction; (c) performing at least two separate primer extension reactions using the tethered nucleic acid molecules as a template to produce multiple distinct sets of primer extension products; (d) separately analyzing the sets of primer extension products using different methods to produce multiple data sets; and (e) integrating the data sets. |
| FILED | Monday, January 04, 2021 |
| APPL NO | 17/785882 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class C12Q 2521/131 (20130101) C12Q 2523/101 (20130101) C12Q 2563/149 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 50/06 (20130101) C40B 70/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230032932 | Butterworth et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Leuko Labs, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ian Butterworth (Somerville, Massachusetts); Carlos Castro-Gonzalez (Cambridge, Massachusetts); Aurelien Bourquard (Madrid, Spain); Alvaro Sanchez Ferro (Madrid, Spain); Ganimete Lamaj (Cambridge, Massachusetts); Nolan Bell (Somerville, Massachusetts); Ryan Benasutti (Milford, New Hampshire); Alberto Pablo-Trinidad (Madrid, Spain) |
| ABSTRACT | An automated system for acquiring images of one or more capillaries in a capillary bed includes a platform for receiving a body portion of a subject, an imaging subsystem having a repositionable field of view and coupled to the platform to acquire images of at least a capillary bed of the body portion and a controller communicably coupled to the imaging subsystem to automatically reposition the field of view of the imaging subsystem to different areas of the capillary bed, and at each field of view within the capillary bed, activate the imaging subsystem to acquire images of one or more capillaries in the capillary bed. |
| FILED | Monday, August 01, 2022 |
| APPL NO | 17/878128 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 19/0085 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 7/10732 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230033047 | Clapper et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Institute For Cancer Research d/b/a The Research Institute of Fox Chase Cancer Center (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Margie L. Clapper (Philadelphia, Pennsylvania); Joseph N. Bodor (Philadelphia, Pennsylvania); Jing Peng (Philadelphia, Pennsylvania); Joseph Treat (Philadelphia, Pennsylvania) |
| ABSTRACT | The present disclosure provides methods of risk stratification for the development of lung cancer and/or lung cancer recurrence, methods of treatment of a human having lung cancer with therapeutic agents for preventing estrogen metabolite production, and methods of treating a human having a high risk of developing lung cancer with therapeutic agents for preventing estrogen metabolite production. |
| FILED | Monday, January 11, 2021 |
| APPL NO | 17/758495 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/05 (20130101) A61K 31/09 (20130101) A61K 31/352 (20130101) A61K 31/404 (20130101) A61K 31/566 (20130101) A61K 31/4196 (20130101) A61K 31/4375 (20130101) A61K 31/7076 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230033099 | Selvaraj et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Periasamy Selvaraj (Lilburn, Georgia); Ramireddy Bommireddy (Johns Creek, Georgia); Luis Enrique Munoz (Decatur, Georgia); Christopher D. Pack (Atlanta, Georgia); Jakkidi Chandra Shaker Reddy (Roswell, Georgia); Sampath Ramachandiran (Duluth, Georgia) |
| ABSTRACT | This disclosure relates to methods of treating cancer using dendritic cells pulsed with tumor membrane vesicles as disclosed herein. In certain embodiments, the tumor membrane vesicles contain fusion proteins with a cytokine and a glycosyl phosphatidylinositol domain. In certain embodiments, the cytokine is granulocyte-macrophage colony-stimulating factor (GM-CSF). In certain embodiments, tumor membrane vesicles contain fusion proteins with IL-12 and a glycosyl phosphatidylinositol domain. |
| FILED | Thursday, July 28, 2022 |
| APPL NO | 17/876413 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/001106 (20180801) Original (OR) Class A61K 2039/812 (20180801) A61K 2039/5154 (20130101) A61K 2039/5158 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230033327 | JANETKA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James W. JANETKA (St. Louis, Missouri); Zhenfu HAN (St. Louis, Missouri); Scott HULTGREN (St. Louis, Missouri); Jerry PINKER (St. Louis, Missouri); CORINNE CUSUMANO (St. Louis, Missouri) |
| ABSTRACT | The present invention encompasses compounds and methods for treating and preventing bacterial infections specifically urinary tract infections and those caused by bacteria containing type 1 pili and FimH. The present invention also encompasses compounds and methods for treating inflammatory bowel disease specifically Crohn's Disease. |
| FILED | Friday, August 26, 2022 |
| APPL NO | 17/896154 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/706 (20130101) A61K 31/7034 (20130101) A61K 31/7042 (20130101) A61K 31/7056 (20130101) A61K 31/7064 (20130101) A61K 45/06 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 15/26 (20130101) C07H 15/203 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230033444 | KNIGHTON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF UTAH RESEARCH FOUNDATION (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nathan J. KNIGHTON (Syracuse, Utah); Robert W. HITCHCOCK (Salt Lake City, Utah); Frank B. SACHSE (Salt Lake City, Utah) |
| ABSTRACT | Disclosed are devices, systems, and methods for characterizing tissue using light scattering spectroscopy. A tissue characterization probe includes an elongate member having a proximal end and a plurality of distal probe tips at a distal end. A plurality of illumination fibers extend through the elongate member to the distal probe tips such that each distal probe tip includes at least one illumination fiber. A plurality of detection fibers also extend through the elongate member such that each probe tip includes at least one detection fiber. The disclosed devices and systems beneficially enable characterization of tissues within depths greater than 100 gm. The disclosed devices and systems also enable effective characterization of anisotropic tissues, such as cardiac myocardium. |
| FILED | Thursday, December 17, 2020 |
| APPL NO | 17/786484 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/0008 (20130101) A61B 5/061 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230033651 | Toner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mehmet Toner (Charlestown, Massachusetts); Avanish Mishra (Dorchester, Massachusetts); Jon F. Edd (Wakefield, Massachusetts) |
| ABSTRACT | Systems, methods, and techniques are disclosed herein for isolating rare cells and clusters of cells, such as CTCs, from large volumes of sample fluids, such as whole blood, diluted blood, e g, minimally diluted blood, and other samples such as leukapheresis and aphaeresis samples. In some implementations, a microfluidic device includes a particle enrichment module and a particle separation module for iterative multistage sorting. Each module can have an array of islands in a microfluidic channel having a sample inlet at a first end of the first microfluidic channel. The array of islands is arranged in one or more rows that extend along a longitudinal direction in the microfluidic channel. Each island in a row is spaced apart from an adjacent island in the row to form a siphoning channel. The array of islands is configured and arranged to shift portions of fluid through the siphoning channel between adjacent islands. |
| FILED | Friday, January 08, 2021 |
| APPL NO | 17/790535 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) Original (OR) Class B01L 2200/0652 (20130101) B01L 2300/0816 (20130101) B01L 2300/0864 (20130101) B01L 2400/043 (20130101) B01L 2400/086 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230034053 | Mahajan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vinit Mahajan (Palo Alto, California); Katherine J. Wert (Dallas, Texas); Gabriel Velez (Palo Alto, California) |
| ABSTRACT | Methods are provided for treating and diagnosing diseases and disorders associated with retinal degeneration, such as retinitis pigmentosa. Dietary supplementation with specific metabolites and vitamins can prolong vision and provide a neuroprotective effect. In particular, dietary supplementation with α-ketoglutarate, or a derivative thereof, significantly prolongs photoreceptor cell survival and visual function. In addition, dietary supplementation with B vitamins and a ketogenic diet also improves photoreceptor cell survival and delays disease progression in some cases. Additionally, compositions, methods, and kits are provided for diagnosing a subject with retinitis pigmentosa based on expression levels of vitreous biomarkers. |
| FILED | Thursday, September 24, 2020 |
| APPL NO | 17/763083 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/07 (20130101) A61K 31/23 (20130101) A61K 31/047 (20130101) A61K 31/202 (20130101) A61K 31/215 (20130101) Original (OR) Class A61K 31/455 (20130101) A61K 31/525 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) G01N 2800/52 (20130101) G01N 2800/164 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230034263 | ZHAO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Weian ZHAO (Irvine, California); Enrico GRATTON (San Clemente, California); Jan ZIMAK (Irvine, California); Tam VU (San Jose, California); Alexander VALLMITJANA (Irvine, California); Joshua GU (Irvine, California); Per Niklas HEDDE (Irvine, California); Lorenzo SCIPIONI (Irvine, California) |
| ABSTRACT | In alternative embodiments, provided are compositions, including products of manufacture and kits, and methods, for in situ spatial profiling of biological materials such as DNA, RNA and protein in cells, tissues, and organisms for investigating biology and for conducting biomarker/drug discovery and development, and for clinical pathology and diagnosis. In alternative embodiments, provided are compositions, including products of manufacture and kits, and methods, for spatially determining, visualizing or quantifying target biological materials comprising in situ staining of a biological sample with one or a plurality of probes that are labeled with light-emitting moieties that exhibit or are encoded with distinct luminescence lifetime (and, optionally, spectrum) characteristics; followed by time-resolved luminescence imaging, measurement and analysis. |
| FILED | Thursday, November 19, 2020 |
| APPL NO | 17/778302 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/682 (20130101) C12Q 1/6818 (20130101) C12Q 1/6841 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230034467 | He et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Linling He (San Diego, California); Jiang Zhu (San Diego, California); Erick Giang (San Diego, California); Mansun Law (San Diego, California); Ian Wilson (La Jolla, California); Netanel Tzarum (Jerusalem, Israel) |
| ABSTRACT | The present invention provides novel engineered HCV E2 polypeptide immunogens and related vaccine compositions that display the engineered E2 polypeptides. The invention also provides methods of using such immunogens and vaccine compositions in various therapeutic applications, e.g., for preventing or treating HCV infections. |
| FILED | Friday, December 17, 2021 |
| APPL NO | 17/554907 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/29 (20130101) A61K 47/6929 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2770/24222 (20130101) C12N 2770/24234 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230034660 | Aizenman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Elias Aizenman (Pittsburgh, Pennsylvania); Athanassios Tzounopoulos (Pittsburgh, Pennsylvania) |
| ABSTRACT | Peptides capable of enhancing N-methyl D-aspartate (NMDA) receptor activity by inhibiting binding of the NMDA receptor GluN2A to zinc transporter 1 (Zn1) are described. The GluN2A-derived peptides can be used to in the treatment of disorders associated with NMDA receptor hypofunction, such as schizophrenia. |
| FILED | Thursday, December 03, 2020 |
| APPL NO | 17/782388 |
| CURRENT CPC | Peptides C07K 7/06 (20130101) Original (OR) Class C07K 7/08 (20130101) C07K 2319/10 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230034732 | Kowalik et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Timothy F. Kowalik (Princeton, Massachusetts); Xiaofei E (Westborough, Massachusetts); Abraham L. Brass (Newton, Massachusetts) |
| ABSTRACT | Methods for treating or reducing the risk of a cytomegalovirus infection in a subject that include administering one or more of an inhibitor of Deleted in Malignant Brain Tumors 1 (DMBT1), an inhibitor of OR14I1, or an inhibitor of adenylyl cyclases. |
| FILED | Tuesday, September 20, 2022 |
| APPL NO | 17/933709 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/52 (20130101) A61K 38/177 (20130101) Original (OR) Class Peptides C07K 16/28 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1138 (20130101) C12N 2310/11 (20130101) C12N 2310/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20230035004 — THERAPEUTIC COMPOSITIONS CONTAINING BACTERIAL OUTER MEMBRANE VESICLES AND USES THEREOF
| US 20230035004 | Heck et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NUtech Ventures (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kari Heck (Lincoln, Nebraska); Amanda Ellen Ramer-Tait (Lincoln, Nebraska); Angela Kaye Pannier (Lincoln, Nebraska) |
| ABSTRACT | This document provides therapeutic compositions, methods of making, and methods of using the described therapeutic compositions that include outer membrane vesicles. |
| FILED | Thursday, July 28, 2022 |
| APPL NO | 17/815729 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5068 (20130101) Original (OR) Class A61K 9/5161 (20130101) A61K 31/713 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230035127 | He et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaoming He (Bethesda, Maryland); Bin Jiang (College Park, Maryland) |
| ABSTRACT | Methods and compositions for the production of cardiomyocytes and cardiac organoids from the differentiation of pluripotent stem cells in three-dimensional (3D) culture are provided. Rock inhibitor, which has been ubiquitously used as a medium supplement to prevent apoptosis during handling and culture of pluripotent stem cells, compromises the capacity of cardiac differentiation of pluripotent stem cells in 3D culture at the most commonly used concentrations. |
| FILED | Thursday, July 21, 2022 |
| APPL NO | 17/814044 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0657 (20130101) C12N 2500/12 (20130101) C12N 2500/32 (20130101) C12N 2500/44 (20130101) C12N 2501/15 (20130101) C12N 2501/115 (20130101) C12N 2501/415 (20130101) C12N 2501/727 (20130101) C12N 2503/02 (20130101) C12N 2506/45 (20130101) C12N 2513/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5061 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230035235 | Kadoch et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cigall Kadoch (Tiburon, California); Nazar Mashtalir (Allston, Massachusetts); Brittany C. Michel (Brookline, Massachusetts); Andrew D'Avino (Boston, Massachusetts) |
| ABSTRACT | The present invention is based, in part, on the novel discovery of the architecture and assembly pathway of three different classes of mammalian SWI/SNF complexes, compositions comprising the isolated modified SWI/SNF complexes, and methods of screening for modulators of the function and/or stability of same. |
| FILED | Tuesday, October 15, 2019 |
| APPL NO | 17/283804 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/4702 (20130101) Original (OR) Class C07K 2319/41 (20130101) C07K 2319/42 (20130101) C07K 2319/43 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6875 (20130101) G01N 2500/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230035239 | Colsen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PHS West, LLC (Charlotte, North Carolina) |
| ASSIGNEE(S) | PHS West, LLC (Charlotte, North Carolina) |
| INVENTOR(S) | Nowell Colsen (St. Francis, Minnesota); Jared Bodin (Waverly, Minnesota) |
| ABSTRACT | A moveable ramp and method of moving cargo using a moveable ramp. The moveable ramp includes a ramp structure comprising a plurality of planar portions including a lower inclined portion, an upper inclined portion, a first horizontal portion extending between the lower inclined portion and the upper inclined portion and a second horizontal portion extending from an upper end of the upper inclined portion wherein the horizontal portions act as landing zones for a delivery tug moving the cargo onto and off of the ramp. The ramp also includes a locking mechanism at the top end to secure the ramp to a pallet, for sample. The ramp may further include automatic struts such as gas struts. |
| FILED | Wednesday, July 27, 2022 |
| APPL NO | 17/874758 |
| CURRENT CPC | Transport or Storage Devices, e.g Conveyors for Loading or Tipping, shop Conveyor Systems Or pneumatic Tube Conveyors B65G 65/00 (20130101) B65G 2201/0267 (20130101) Finishing Work on Buildings, e.g Stairs, Floors E04F 11/002 (20130101) Original (OR) Class E04F 2011/007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230035422 | Stockwell et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brent R. Stockwell (New York, New York); Tal Hirschhorn (New York, New York); Fereshteh Zandkarimi (New York, New York); Arie Zask (New York, New York) |
| ABSTRACT | The present disclosure provides, inter alia, methods for treating diseases, e.g., a cancer, in a subject by targeting oncogenic lipids in cells, including increasing lipid-based reactive oxygen species (ROS) by inhibiting coenzyme Q10 (CoQ10) production. Methods for treating a subject with a cancer that is sensitive to an oncolipid-targeting therapy, e.g., ADCK3 inhibition, are also provided. Further provided are methods for modulating coenzyme Q10 (CoQ10) level in a subject, including determining CoQ10 levels by LC-MS. |
| FILED | Monday, October 03, 2022 |
| APPL NO | 17/958741 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/18 (20130101) A61K 31/337 (20130101) A61K 31/357 (20130101) A61K 31/437 (20130101) A61K 31/455 (20130101) A61K 31/475 (20130101) A61K 31/495 (20130101) A61K 31/513 (20130101) A61K 31/517 (20130101) A61K 31/519 (20130101) A61K 31/573 (20130101) A61K 31/655 (20130101) A61K 31/675 (20130101) A61K 31/704 (20130101) A61K 31/4453 (20130101) A61K 31/4706 (20130101) Original (OR) Class A61K 33/243 (20190101) A61K 38/14 (20130101) A61K 39/3955 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230035479 | Hsu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ya-Chieh Hsu (Cambridge, Massachusetts); Bing Zhang (Cambridge, Massachusetts); David E. Fisher (Newton, Massachusetts); Inbal Rahamin (Brookline, Massachusetts) |
| ABSTRACT | Disclosed herein are methods and compositions for reducing and/or preventing hair greying in a subject. |
| FILED | Wednesday, March 25, 2020 |
| APPL NO | 17/762026 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 31/135 (20130101) Original (OR) Class A61K 31/496 (20130101) A61K 38/4893 (20130101) Specific Use of Cosmetics or Similar Toilet Preparations A61Q 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230035606 | GE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Ying GE (Madison, Wisconsin); Song JIN (Madison, Wisconsin); Timothy-Neil T. TIAMBENG (Madison, Wisconsin); David S. ROBERTS (Madison, Wisconsin) |
| ABSTRACT | This invention provides mass spectrometry (MS) compatible nanomaterials for the selective capture and enrichment of low abundance proteins as well as MS analysis of different proteoforms of proteins, particularly cardiac proteins and different proteoforms of cardiac troponin I (cTnI) arising from post-translational modifications and sequence variations. The surface of superparamagnetic nanoparticles is functionalized with probe molecules that specifically bind to the desired protein. In an embodiment, the nanoparticles are functionalized with probe molecules having high affinity and selectivity for cTnI within the human cardiac troponin complex. This allows for MS-analysis and characterization of cTnI proteoforms from human heart tissue lysates and human blood or serum samples, and provides an accurate assay for detection of cTnI with molecular details. Such assays are useful for accurate diagnosis of acute coronary syndrome and chronic diseases, including acute myocardial infarction and other cardiac injuries, as well as risk stratification and outcome assessment for patients. |
| FILED | Friday, December 18, 2020 |
| APPL NO | 17/786482 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/14 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/68 (20130101) G01N 33/90 (20130101) G01N 33/54333 (20130101) G01N 2333/4712 (20130101) G01N 2800/324 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 1/36 (20130101) H01F 1/0054 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230035727 | HUNG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | COMBINATI INCORPORATED (Carlsbad, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ju-Sung HUNG (Palo Alto, California); Felicia LINN (Patterson, California); Robert LIN (Palo Alto, California) |
| ABSTRACT | The present disclose provides methods for forming a microfluidic device. Methods for forming a microfluidic device may comprise providing a microfluidic structure and a film, treating a surface of the microfluidic structure, a surface of the film, or both with a solvent, subsequently pressing the microfluidic structure together with the film under a first heating condition to form the microfluidic device comprising the solvent, and applying a negative pressure to the microfluidic device under a second heating condition, which negative pressure is applied for a time period greater than 30 minutes or at a pressure less than 20 kilopascals (kPa) to remove at least a portion of the solvent. In some aspects, the present disclosure provides devices consistent with the methods herein. |
| FILED | Friday, January 22, 2021 |
| APPL NO | 17/759070 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502707 (20130101) Original (OR) Class B01L 2300/0864 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 71/02 (20130101) B29C 71/0009 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230035859 | Bruno et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter M. Bruno (Brookline, Massachusetts); Stephen J. Elledge (Brookline, Massachusetts) |
| ABSTRACT | Described herein are methods for identification of peptides that bind MHC-I molecules from within a starting pool of candidate epitope peptides, using a cell-based genetic immunopeptidomic screen. |
| FILED | Wednesday, December 02, 2020 |
| APPL NO | 17/780407 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) C07K 14/70539 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/00 (20130101) C12N 15/86 (20130101) C12N 15/625 (20130101) C12N 15/1037 (20130101) C12N 15/1138 (20130101) Original (OR) Class C12N 2740/15043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230035942 | Murphy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William L. Murphy (Waunakee, Wisconsin); Gianluca Fontana (Madison, Wisconsin); Andrew Khalil (Madison, Wisconsin); Jae-Sung Lee (Madison, Wisconsin) |
| ABSTRACT | Disclosed are compositions having mineral crystals and biological molecules for the delivery of the biological materials and methods for preparing mineral crystals having a biologic material. |
| FILED | Thursday, July 21, 2022 |
| APPL NO | 17/814128 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/501 (20130101) Original (OR) Class A61K 48/0033 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/88 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230036060 | WANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yingxiao WANG (Oakland, California); Molly E. ALLEN (Oakland, California); Ziliang HUANG (Oakland, California) |
| ABSTRACT | Provided are compositions, including products of manufacture and kits, and methods, for remotely-controlled and non-invasive manipulation of intracellular nucleic acid expression, genetic processes, function and activity in live cells such as a T cell, a primary T cell, a B cell, a monocyte, a macrophage, a dendritic cell or a natural killercell in vivo, for example, including activating, adding functions or changing or adding specificities for an immune cell, for monitoring physiologic processes, for the correction of pathological processes and for the control of therapeutic outcomes. Provided are tamoxifen-gated photoactivatable split-Cre recombinase optogenetic systems, called TamPA-Cre, that feature high spatiotemporal control to control or alter cell activities in vivo, for example, to limit the activity of a Chimeric Antigen Receptor (CAR)-expressing cell such as an immune cell and its activity at a tumor site for immunotherapy applications. |
| FILED | Friday, September 25, 2020 |
| APPL NO | 17/763900 |
| CURRENT CPC | Peptides C07K 2319/09 (20130101) C07K 2319/32 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1241 (20130101) C12N 15/635 (20130101) Original (OR) Class C12N 2740/15043 (20130101) C12N 2800/30 (20130101) C12N 2830/002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230036131 | LI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qiuhong LI (Gainesville, Florida); Mohan RAIZADA (Alachua, Florida) |
| ABSTRACT | Provided herein are polynucleic acids and expression vectors for the expression and secretion of angiotensin peptide fragments (e.g., angiotensin-(1-7)) in probiotic bacteria. Provided herein are also probiotic compositions that enable efficient, cost-effective and patient friendly oral therapeutics for treating diverse pathological conditions that involve the renin-angiotensin system (RAS), e.g., pulmonary hypertension, diabetes, diabetic complications, cardiovascular diseases, and ocular inflammatory and neurodegenerative diseases. |
| FILED | Tuesday, June 14, 2022 |
| APPL NO | 17/839815 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/74 (20130101) A61K 35/741 (20130101) A61K 35/747 (20130101) A61K 45/06 (20130101) A61K 48/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/00 (20180101) A61P 3/10 (20180101) A61P 9/12 (20180101) A61P 27/02 (20180101) A61P 29/00 (20180101) Peptides C07K 7/14 (20130101) C07K 14/28 (20130101) C07K 14/47 (20130101) C07K 14/195 (20130101) C07K 14/575 (20130101) Original (OR) Class C07K 19/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/00 (20130101) C12N 9/485 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230036134 | Solanki et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | EYENUK, INC. (Woodland Hills, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kaushal Mohanlal Solanki (West Hills, California); Chaithanya Amai Ramachandra (West Hills, California); Sandeep Bhat Krupakar (West Hills, California); Malavika Bhaskaranand (West Hills, California) |
| ABSTRACT | Embodiments disclose systems and methods that aid in screening, diagnosis and/or monitoring of medical conditions. The systems and methods may allow, for example, for automated identification and localization of lesions and other anatomical structures from medical data obtained from medical imaging devices, computation of image-based biomarkers including quantification of dynamics of lesions, and/or integration with telemedicine services, programs, or software. |
| FILED | Friday, June 10, 2022 |
| APPL NO | 17/838103 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/12 (20130101) A61B 3/14 (20130101) A61B 3/0025 (20130101) Electric Digital Data Processing G06F 16/51 (20190101) G06F 16/583 (20190101) G06F 16/5866 (20190101) Image Data Processing or Generation, in General G06T 3/40 (20130101) G06T 3/0068 (20130101) G06T 3/0093 (20130101) G06T 5/008 (20130101) G06T 5/20 (20130101) G06T 7/0012 (20130101) G06T 7/0014 (20130101) G06T 7/0016 (20130101) Image or Video Recognition or Understanding G06V 10/44 (20220101) G06V 10/50 (20220101) G06V 10/267 (20220101) G06V 10/758 (20220101) G06V 40/18 (20220101) G06V 40/193 (20220101) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/20 (20180101) G16H 30/40 (20180101) G16H 50/20 (20180101) Information and Communication Technology [ICT] Specially Adapted for Specific Application Fields, Not Otherwise Provided for G16Z 99/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230036213 | HARRIS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CHILDREN'S NATIONAL MEDICAL CENTER (Washington, District of Columbia) |
| ASSIGNEE(S) | CHILDREN'S NATIONAL MEDICAL CENTER (Washington, District of Columbia) |
| INVENTOR(S) | Katherine HARRIS (Washington, District of Columbia); Michael KELLER (Washington, District of Columbia); Catherine BOLLARD (Washington, District of Columbia) |
| ABSTRACT | Disclosed are compositions of T-cells, libraries of such T-cells, and methods of making T-cell subpopulations for treatment of human parainfluenza virus (HPIV) infections, particularly HPIV type 3 (HPIV3) infections. Also disclosed are T-cell compositions comprising cell subpopulations stimulated with HPIV3 antigens and T cell banks containing these compositions for off-the-shelf availability of T cells for treatment of disease. |
| FILED | Thursday, December 10, 2020 |
| APPL NO | 17/784072 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 39/12 (20130101) A61K 39/39 (20130101) A61K 2039/5158 (20130101) Peptides C07K 14/115 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230036273 | Joung et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | J. Keith Joung (Winchester, Massachusetts); Y. Esther Tak (Charlestown, Massachusetts) |
| ABSTRACT | Provided herein are artificial transcription factor systems and related methods for modulating gene expression. |
| FILED | Wednesday, November 25, 2020 |
| APPL NO | 17/779372 |
| CURRENT CPC | Peptides C07K 14/4702 (20130101) Original (OR) Class C07K 2319/80 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/62 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230036340 | Qyang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yibing Qyang (Guilford, Connecticut); Laura Niklason (Greenwich, Connecticut); Jiesi Luo (New Haven, Connecticut); Lingfeng Qin (Hamden, Connecticut); Liqiong Gui (Irvine, California); Matthew Ellis (Issaquah, Washington) |
| ABSTRACT | The present invention provides a tissue-engineering vascular graft (TEVG) comprising a biodegradable scaffold, and a plurality of stem cell-derived vascular smooth muscle cells (VSMCs), wherein the plurality of stem cell-derived VSMCs are seeded on the biodegradable synthetic polymer scaffold and are cultured under mechanical and biochemical stimulation. |
| FILED | Friday, December 04, 2020 |
| APPL NO | 17/781478 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/062 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 35/44 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) A61L 27/54 (20130101) A61L 27/58 (20130101) A61L 27/3834 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0691 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230036370 | Mali et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Prashant Mali (La Jolla, California); Dhruva Katrekar (La Jolla, California) |
| ABSTRACT | Disclosed herein are engineered guide RNAs, constructs for forming engineered guide RNAs, pharmaceutical compositions thereof, methods of making the engineered guide RNAs, and methods of treating or preventing a diseases and disorders of a subject by administering one or more of the engineered guide RNAs or the constructs for forming the engineered guide RNAs. |
| FILED | Tuesday, December 01, 2020 |
| APPL NO | 17/781686 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/78 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/531 (20130101) C12N 2310/532 (20130101) C12N 2320/51 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230036392 | Kim |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sunyoung Kim (New Orelans, Louisiana) |
| ABSTRACT | This invention is directed to compositions and methods to detect and treat gastrointestinal diseases. |
| FILED | Tuesday, February 04, 2020 |
| APPL NO | 17/428416 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/573 (20130101) Original (OR) Class G01N 2333/916 (20130101) G01N 2800/52 (20130101) G01N 2800/065 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230036585 | Horan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Annamarie D. Horan (Philadelphia, Pennsylvania); Samir Mehta (Haddonfield, New Jersey); Donald A. Baldwin (Newtown Square, Pennsylvania) |
| ABSTRACT | The present invention relates to the discovery that the expression levels of some RNA molecules, comprising messenger RNA (mRNA), non-coding RNA (ncRNA) and/or microRNA (miRNA), and protein can be used as a diagnostic signature to predict or monitor the bone healing ability in an acutely injured subject or in a chronic nonunion subject. In certain embodiments, the invention relates to methods and compositions useful for differentiating between a nonunion, slow healing, and/or normal healing of a fractured bone and treatment recommendations. The invention further includes a kit comprising biomarker probes for assessing the bone healing ability in an acutely injured subject or in a nonunion subject after receiving therapeutic treatment. |
| FILED | Friday, May 06, 2022 |
| APPL NO | 17/738585 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/158 (20130101) C12Q 2600/178 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/68 (20130101) G01N 33/6887 (20130101) G01N 33/6893 (20130101) G01N 2570/00 (20130101) G01N 2800/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230036685 | BURKE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | John Douglas BURKE (Rockville, Maryland); Fabio CANDOTTI (Chardonne, Switzerland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Douglas BURKE (Rockville, Maryland); Fabio CANDOTTI (Chardonne, Switzerland) |
| ABSTRACT | Provided is a viral particle comprising a genomic RNA suitable for delivering a polynucleotide sequence of interest (SOI) into a cell and/or a subject. The genomic RNA comprises, from 5′ to 3′: (a) the SOI replacing the upstream R, (b) a U5, (c) a primer binding site (PBS), (d) an encapsidation signal (Psi), (e) polypurine tract(s) (PPT), and (f) a U3. The SOI preferably takes the form of single-stranded DNA or a DNA-RNA hybrid after initiation of reverse transcription. Additionally provided are polynucleotides, vectors, cells, components, compositions, kits, methods and uses of the viral particle. |
| FILED | Wednesday, September 30, 2020 |
| APPL NO | 17/754211 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 15/907 (20130101) C12N 2310/20 (20170501) C12N 2740/15022 (20130101) C12N 2740/15042 (20130101) C12N 2740/15043 (20130101) C12N 2740/15052 (20130101) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230036788 | BENNETT et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anton BENNETT (Wilton, Connecticut); Jae-Sung YI (Hamden, Connecticut) |
| ABSTRACT | The present invention provides compositions and methods of inhibiting tyrosine phosphorylation. In one aspect, a composition comprising a low-dosage tyrosine kinase inhibitor, where the low-dosage tyrosine kinase inhibitor decreases tyrosine phosphorylation, is provided. In another aspect, a method for treating cardiovascular disease or condition associated with a RASopathy having aberrant protein tyrosine phosphorylation is described. Methods for treating congenital heart disease associated with Noonan or Noonan syndrome with multiple lentigines and decreasing aberrant levels of Protein Zero-Related (PZR) tyrosyl phosphorylation are also described. |
| FILED | Tuesday, August 30, 2022 |
| APPL NO | 17/823439 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/506 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230036839 | Lin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | The University of Chicago (Chicago, Illinois) |
| INVENTOR(S) | Wenbin Lin (Chicago, Illinois); Christina Chan (Chicago, Illinois); Wenbo Han (Chicago, Illinois) |
| ABSTRACT | Nanoparticles comprising micheliolide (MCL) or derivatives thereof, and optionally additional therapeutic agents, such as chemotherapeutic agents, are described. Also described are methods of treating diseases, such as cancer, comprising the use of combinations of MCL or a derivative thereof with X-ray irradiation and/or other therapeutic agents, such as immune checkpoint inhibitors. The use of the combinations can provide synergistic anticancer therapeutic efficacy, for example, as the MCL or derivative thereof can both sensitize cancer cells to therapy and target resistant cancer stem cells (CSCs) for selective cell death. |
| FILED | Thursday, June 30, 2022 |
| APPL NO | 17/855327 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/343 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 47/6803 (20170801) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/10 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 37/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230036952 | Good et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Meghan L. Good (Derwood, Maryland); Rafiqul SM Islam (Bethesda, Maryland); Naritaka Tamaoki (North Bethesda, Maryland); Raul E. Vizcardo (North Bethesda, Maryland); Nicholas P. Restifo (Chevy Chase, Maryland) |
| ABSTRACT | Provided are methods of producing an isolated population of T cells for adoptive cell therapy. Also provided are related isolated populations of cells, pharmaceutical compositions, and methods of treating or preventing cancer, infections, and autoimmune conditions in a patient. |
| FILED | Thursday, January 07, 2021 |
| APPL NO | 17/790939 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 37/02 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) Original (OR) Class C12N 2501/2302 (20130101) C12N 2501/2307 (20130101) C12N 2501/2312 (20130101) C12N 2501/2315 (20130101) C12N 2506/45 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230037048 | Badylak et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen F. Badylak (West Lafayette, Indiana); Donald Freytes (Pittsburgh, Pennsylvania) |
| ABSTRACT | Provided are methods for preparing gelled, solubilized extracellular matrix (ECM) compositions useful as cell growth scaffolds. Also provided are compositions prepared according to the methods as well as uses for the compositions. In one embodiment a device, such as a prosthesis, is provided which comprises an inorganic matrix into which the gelled, solubilized ECM is dispersed to facilitate in-growth of cells into the ECM and thus adaptation and/or attachment of the device to a patient. |
| FILED | Friday, March 11, 2022 |
| APPL NO | 17/692530 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/12 (20130101) A61K 38/00 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/34 (20130101) A61L 27/38 (20130101) A61L 27/52 (20130101) A61L 27/54 (20130101) A61L 27/3633 (20130101) Original (OR) Class A61L 27/3687 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20230029935 | Kantany et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Technologies Corporation (Farmington, Connecticut) |
| ASSIGNEE(S) | Raytheon Technologies Corporation (Farmington, Connecticut) |
| INVENTOR(S) | Nicholas W. Kantany (Manchester, Connecticut); Edward Boucher (Avon, Connecticut); Kristine Marie Carnavos (Providence, Rhode Island); Robert Russell Mayer (Manchester, Connecticut); Donald W. Peters (Colchester, Connecticut) |
| ABSTRACT | A system for modulating air flow in a gas turbine engine is provided. The system may include a seal wall comprising an opening, a seal door configured to slideably engage the seal wall, and an actuator configured to move the seal door over the opening. In various embodiments, the system may include a surface forward of the seal door. The seal door may be configured to seal a passage through the surface and the opening of the seal wall. A track may be disposed under the seal door. The track may comprise cobalt. Rollers may be coupled to the seal door with the rollers on the track. The seal door may comprise a nickel-chromium alloy. A sync ring may be coupled to the seal door. The actuator may be coupled through the sync ring to the seal door. |
| FILED | Monday, October 03, 2022 |
| APPL NO | 17/958682 |
| CURRENT CPC | Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/28 (20130101) Original (OR) Class F02C 9/20 (20130101) Jet-propulsion Plants F02K 3/075 (20130101) F02K 3/115 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230030549 | Anderson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Travis J. Anderson (Alexandria, District of Columbia); Mona A. Ebrish (Alexandria, Virginia); Andrew D. Koehler (Alexandria, Virginia); Alan G. Jacobs (Rockville, Maryland); Matthew A. Porter (Virginia Beach, Virginia); Karl D. Hobart (Alexandria, Virginia); Prakash Pandey (Toledo, Ohio); Tolen Michael Nelson (Tecumseh, Michigan); Daniel G. Georgiev (Canton, Michigan); Raghav Khanna (Toledo, Ohio); Michael Robert Hontz (Drexel Hill, Pennsylvania) |
| ABSTRACT | A hybrid edge termination structure and method of forming the same. The hybrid edge termination structure in accordance with the invention is based on a junction termination extension (JTE) architecture, but includes an additional Layer of guard ring (GR) structures to further implement the implantation of dopants into the structure. The hybrid edge termination structure of the invention has a three-Layer structure, with a top Layer and a bottom Layer each having a constant dopant concentration in the lateral direction, and a middle Layer consisting of a plurality of spatially defined alternating regions that exhibit the electrical properties of either the top or bottom layer. By including the second layer, a discretized varying charge profile can be obtained that approximates the varying charge profile obtained using tapered edge termination but with easier manufacturing and lower cost. |
| FILED | Thursday, July 28, 2022 |
| APPL NO | 17/876163 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/0615 (20130101) Original (OR) Class H01L 29/861 (20130101) H01L 29/2003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230030878 | Chown et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Achates Power, Inc. (San Diego, California) |
| ASSIGNEE(S) | Achates Power, Inc. (San Diego, California) |
| INVENTOR(S) | Daniel M. Chown (Reno, Nevada); Ryan G. MacKenzie (San Diego, California); Isaac B. Thomas (Carson City, New York) |
| ABSTRACT | In an opposed-piston engine, a piston has a top land. The piston top land has a non-cylindrical shape which affords more clearance with a piston bore to thrust and anti-thrust sides than to front-facing and rear facing sides. |
| FILED | Tuesday, July 26, 2022 |
| APPL NO | 17/873473 |
| CURRENT CPC | Machines or Engines, in General or of Positive-displacement Type, e.g Steam Engines F01B 7/02 (20130101) Internal-combustion Piston Engines; Combustion Engines in General F02B 75/282 (20130101) Original (OR) Class F02B 2075/025 (20130101) Cylinders, Pistons or Casings, for Combustion Engines; Arrangements of Sealings in Combustion Engines F02F 3/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230030893 | Donaldson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Critical Innovations, LLC (Lawndale, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ross I. Donaldson (Lawndale, California); Oliver Buchanan (Lawndale, California); Muhammed Hamdan (Lawndale, California); Jonathan Armstrong (Lawndale, California); John Cambridge (Lawndale, California); Nely Cristerna (Lawndale, California) |
| ABSTRACT | An improved method and device are provided for treating wounds. The device generally comprises a wound chamber and/or deployment system. The provided assembly substantially improves wound treatment. |
| FILED | Thursday, July 28, 2022 |
| APPL NO | 17/876187 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 9/0008 (20130101) Original (OR) Class Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 35/10 (20190501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230030993 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Palo Alto Research Center Incorporated (Palo Alto, California) |
| ASSIGNEE(S) | Palo Alto Research Center Incorporated (Palo Alto, California) |
| INVENTOR(S) | Randi Wang (Mountain View, California); Morad Behandish (San Mateo, California); Ion Matei (Santa Cruz, California) |
| ABSTRACT | Methods and systems (e.g., for generating selecting a model-order reduction (MOR) technique and/or level of granularity for a MOR that provide at least one of: (a) flexible cost-accuracy tradeoffs, (b) a priori error bounds, and (c) a priori preservation of properties that provide physical fidelity) may include: providing governing equations for a physical system; defining quantities of interest (QoI) for the physical system; semi-discretizing the governing equations to obtain a full-order model (FOM) using a state-space representation; applying a MOR technique to the FOM to obtain a family of ROMs with different cost and accuracy tradeoffs, wherein each ROM approximates the FOM with respect to the QoI; and selecting one or more preferred ROMs from the family of ROMs based, at least in part, on the cost and accuracy tradeoffs. |
| FILED | Wednesday, July 28, 2021 |
| APPL NO | 17/386674 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/20 (20200101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230031155 | Zhao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rohr, Inc. (Chula Vista, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wenping Zhao (Glastonbury, Connecticut); John J. Gangloff, JR. (Middleton, Connecticut); Michael A. Klecka (Coventry, Connecticut); Zhigang Wang (South Windsor, Connecticut); Abhijit Chakraborty (West Hartford, Connecticut) |
| ABSTRACT | An end effector for welding composite components includes an end effector housing and a welding member mounted to the end effector housing. The end effector further includes a leading roller mounted to the end effector housing forward of the welding member and at least one follower roller mounted to the end effector housing aft of the welding member. The end effector further includes at least one first cooling air jet positioned to direct a first stream of cooling air toward the at least one follower roller. |
| FILED | Monday, August 02, 2021 |
| APPL NO | 17/391787 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 11/005 (20130101) B25J 15/0019 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 65/32 (20130101) B29C 66/82 (20130101) Original (OR) Class B29C 66/0342 (20130101) B29C 66/721 (20130101) B29C 66/7392 (20130101) Electric Heating; Electric Lighting Not Otherwise Provided for H05B 6/105 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230031238 | GANDY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Applied Minds, LLC (Burbank, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles L. GANDY (Annapolis, Maryland); Clinton Blake HOPE (Los Angeles, California); Edward Francis ADAMS (Los Angeles, California); Donald Gregory LARIVIERE (Glendale, California); Houstin L. LICHTENWALNER (Macungie, Pennsylvania) |
| ABSTRACT | Disclosed are passive reflector radio communications systems, such as for UHF frequencies or greater than UHF frequencies, and related deployment systems and devices that provide underground communications. Embodiments of the system include reflector elements to provide passive radio communications, structural frameworks to support and orient the reflector elements, methods for calculating reflector size, shape, and position corresponding to a desired wavelength, and deployment methods and devices to install the communication system at a desired location. The passive reflectors can be placed in a folded or otherwise compact mode, for transport into underground tunnels. Once at the desired installation location, the system can be installed, with the reflectors positioned appropriately for the radio frequencies used at the location. Some of the embodiments include any of vertical or horizontal foldable reflector poles, reflective sheets, reflective mesh sheets and/or ropes, inflatable reflective pucks, and rapid deployment systems and methods. |
| FILED | Monday, September 26, 2022 |
| APPL NO | 17/935227 |
| CURRENT CPC | Transmission H04B 7/145 (20130101) Original (OR) Class H04B 7/15507 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 67/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230031266 | Chowdhury et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Stanford, None); The Board of Trustrees of the Leland Stanford Junior University (Stanford, None) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Srabanti Chowdhury (San Ramon, California); Mohamadali Malakoutian (Davis, California); Matthew A. Laurent (Rancho Palos Verdes, California); Chenhao Ren (Davis, California); Siwei Li (Davis, California) |
| ABSTRACT | In certain examples, methods and semiconductor structures are directed to a method comprising steps of forming by monolithically integrating or seeding via polycrystalline diamond (PCD) particles on a GaN-based layer characterized as including GaN in at least a surface region of the GaN-based layer. After the step of seeding, the PCD particles are grown under a selected pressure to form a diamond layer section and to provide a semi-conductive structure that includes the diamond layer section integrated on or against the surface region of the GaN-based layer. |
| FILED | Friday, January 08, 2021 |
| APPL NO | 17/790675 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/02458 (20130101) H01L 21/02527 (20130101) H01L 21/02595 (20130101) H01L 27/088 (20130101) H01L 27/0605 (20130101) H01L 27/0617 (20130101) H01L 27/1203 (20130101) H01L 29/267 (20130101) Original (OR) Class H01L 29/1602 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230031411 | Christophersen et al. |
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| FUNDED BY |
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| APPLICANT(S) | GOVENMENT OF UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (ARLINGTON, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marc Christophersen (Berwyn Heights, Maryland); Bermard F. Phlips (Great Falls, Virginia) |
| ABSTRACT | A conformally metal-coated glass capillary array and method of fabricating same. A glass capillary array is provided. The glass capillary array includes a plurality of glass capillaries. The glass capillary array includes a plurality of glass capillary array walls. The plurality of glass capillary array walls define a plurality of holes. The plurality of holes includes a plurality of hole peripheries. An electroless metallization catalyst is provided around the plurality of hole peripheries. A first metal is electroless plated on the plurality of glass capillary array walls using the electroless metallization catalyst. A second metal is electroplated on the electroless-plated, first metal, or the second metal is electroless-plated on the electroless-plated, first metal. |
| FILED | Thursday, May 26, 2022 |
| APPL NO | 17/825100 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/72 (20130101) B01J 23/755 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/00 (20130101) B01L 2300/0838 (20130101) Manufacture, Shaping, or Supplementary Processes C03B 37/14 (20130101) Original (OR) Class Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 30/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230031750 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | University of Southern California (Los Angeles, California) |
| INVENTOR(S) | Tianye Li (Los Angeles, California); Yajie Zhao (Los Angeles, California); Shichen Liu (Los Angeles, California); Jiayi Liu (Los Angeles, California); Hao Li (Los Angeles, California) |
| ABSTRACT | Systems and methods are provided for generating topologically consistent meshes across various subjects, objects, and/or various facial expressions using a volumetric representation. In one example, a progressive mesh generation network is configured to embed the topological structure of a subject or an object in a feature volume sampled from a geometry-aware local features. Further, a coarse-to-fine iterative architecture facilitates dense and accurate facial mesh predictions using a consistent mesh topology. In another example, one or more high-quality asset maps may be generated from a final base mesh. |
| FILED | Tuesday, May 03, 2022 |
| APPL NO | 17/735568 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 3/40 (20130101) G06T 17/20 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230031761 | DHINOJWALA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Akron (Akron, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ali DHINOJWALA (Akron, Ohio); Saranshu SINGLA (SANGRUR, India); Dharamdeep JAIN (Jammu, India) |
| ABSTRACT | In one or more embodiments, the present invention provides a polymer composition for use in, cosmetics, coatings, inks, polymer compounding formulation comprising an all-natural, DHN-based, nitrogen-free black knot fungal (BKF) allomelanin extracted from black knots (a fungal growth formed by Apiosporina morbosa). The BKF melanin is naturally sourced, economically extracted, and quite unexpectedly, has been found to have better UV absorbing and antioxidant properties than synthetic melanin (polydopamine) and commercially available sepia melanin. In various embodiments, a small amount of the BKF melanin is substantially uniformly blended into a polymer or similar material to create a composition having excellent UV absorption and antioxidant properties. Surprisingly, it has also been found that the UV absorption and antioxidant properties of these polymer compositions can withstand heating and other processing steps associated with polymers, and in particular, rubber without significant reduction in effectiveness. |
| FILED | Tuesday, May 31, 2022 |
| APPL NO | 17/828703 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/26 (20130101) C08J 2307/00 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 11/00 (20130101) Original (OR) Class C08K 2201/012 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/32 (20130101) C09D 7/63 (20180101) C09D 107/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230031770 | Podlesak et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States, as represented by the Secretary of the Army (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas Podlesak (Elkton, Maryland); Michael Gonzalez (Bel Air, Maryland) |
| ABSTRACT | Various embodiments are described that relate an electrical current connector. The electrical current connector can be configured to provide electrical current when pressure is applied to a prong set. This pressure can cause a contact to engage with a connector. This can complete a circuit that allows the electrical current to flow. The connector can be coupled to a cable that can be configured to transfer data along with the electrical current. The cable can have an inner portion that transfers the data while an outer portion that surrounds the inner portion transfers the current. |
| FILED | Friday, October 14, 2022 |
| APPL NO | 17/965884 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/50 (20200101) Original (OR) Class Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors H01R 13/193 (20130101) H01R 13/6683 (20130101) H01R 13/7038 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230031780 | Cheung et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America as represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jennifer Miuling Cheung (San Diego, California); Antonio Monje (San Diego, California) |
| ABSTRACT | A method for identifying data exfiltration attempts on a computer network comprising the following steps: identifying malicious data exfiltration behaviors (DEBs) for known adversary tactics in a knowledge base; identifying benign DEBs; comparing the malicious DEBs with the benign DEBs to identify network features that indicate malicious DEB; calculating, with a network analyzer, an entropy value for each identified network feature; establishing a threshold based on the calculated entropy values; building a complete profile of DEB based on the benign and malicious DEBs; adding every network feature having an entropy value greater than the threshold to a model; comparing the model to live network traffic; and flagging behavior in the live network traffic as a malicious DEB if such behavior includes a network feature that has an entropy value greater than the threshold regardless of whether or not the flagged behavior was previously recognized as a malicious DEB. |
| FILED | Tuesday, July 27, 2021 |
| APPL NO | 17/386073 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 63/1416 (20130101) H04L 63/1425 (20130101) H04L 63/1466 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230032125 | McNicholas et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | William McNicholas (Ellettsville, Indiana); Joshua E. Gwaltney (Sandborn, Indiana); Eric Scheid (Bloomington, Indiana); Matt E Cummings (Bedford, Indiana); Andrew Richard Davis (Mesa, Arizona) |
| ABSTRACT | Provided is a frangible munitions device optimized for a dome and cylinder that yields fragments having shapes corresponding to a predetermined embossment pattern upon explosive rupture. The embossment pattern includes a first set of inner regular hexagonal embossments formed into the dome and cylinder that are aligned with the axis of the cylinder, and a second set of outer pre-deformed hexagonal shapes that distort to produce regular hexagonal shapes after drawing into the cylinder wall. The second set of shapes are separated by sharp transition regions. The shapes are embossed in a repeated pattern around the hollow cylinder and the dome top. The dome yields a plurality of fragments having shapes corresponding to the first set of inner regular hexagonal embossments upon explosive rupture, while the cylinder yields a plurality of fragments having shapes corresponding to the second set of outer pre-deformed hexagonal embossments upon explosive rupture. |
| FILED | Thursday, July 28, 2022 |
| APPL NO | 17/876231 |
| CURRENT CPC | Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 12/22 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230032335 | Martínez et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | José F. Martínez (Ithaca, New York); Helena Caminal (Ithaca, New York); Kailin Yang (Ithaca, New York); Khalid Al-Hawaj (Ithaca, New York); Christopher Batten (Ithaca, New York) |
| ABSTRACT | A content-addressable processing engine, also referred to herein as CAPE, is provided. Processing-in-memory (PIM) architectures attempt to overcome the von Neumann bottleneck by combining computation and storage logic into a single component. CAPE provides a general-purpose PIM microarchitecture that provides acceleration of vector operations while being programmable with standard reduced instruction set computing (RISC) instructions, such as RISC-V instructions with standard vector extensions. CAPE can be implemented as a standalone core that specializes in associative computing, and that can be integrated in a tiled multicore chip alongside other types of compute engines. Certain embodiments of CAPE achieve average speedups of 14× (up to 254×) over an area-equivalent out-of-order processor core tile with three levels of caches across a diverse set of representative applications. |
| FILED | Thursday, September 22, 2022 |
| APPL NO | 17/950560 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/3001 (20130101) G06F 9/3004 (20130101) G06F 9/30036 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230033110 | MOORE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOEING COMPANY (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James A. MOORE (Gilbert, Arizona); Daniel W. Huff (Scottsdale, Arizona); Dennis K. Kennedy (Mesa, Arizona) |
| ABSTRACT | The present disclosure provides methods for forming sol-gels, sol-gel films and substrates, such as vehicle components, having a sol-gel film disposed thereon. At least one method of forming a sol-gel includes mixing a metal alkoxide, an acid stabilizer, and an organic solvent to form a first mixture having about 10 wt % or less water content based on the total weight of the first mixture. The method includes mixing an organosilane with the first mixture to form a second mixture having about 10 wt % or less water content based on the total weight of the second mixture. |
| FILED | Tuesday, September 06, 2022 |
| APPL NO | 17/903331 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/003 (20130101) B01J 13/0065 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 1/00 (20130101) C09D 5/08 (20130101) Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 5/02 (20130101) C09J 9/00 (20130101) Original (OR) Class C09J 11/06 (20130101) C09J 2400/163 (20130101) C09J 2400/166 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 18/122 (20130101) C23C 18/1216 (20130101) C23C 18/1241 (20130101) C23C 18/1254 (20130101) C23C 22/73 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230033374 | Ritter et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Markus Fabian Ritter (Adliswil, Switzerland); Fabrizio Nichele (Zurich, Switzerland); Heinz Schmid (Wädenswil, Switzerland); Heike Erika Riel (Baech, Switzerland) |
| ABSTRACT | Embodiments of the invention relate to a method for fabricating a semiconductor structure comprising a semiconductor material, and a semiconductor substrate fabricated from the method. The method can include a step of providing a template structure. The template structure can comprise an opening, a cavity and a seed structure. The seed structure can comprise a seed material and a seed surface. An inner surface of the template structure can comprise at least one metallic surface area comprising a metallic material. The embodied method further comprises a step of growing the semiconductor structure within the cavity of the template structure from the seed surface along the metallic surface area. |
| FILED | Wednesday, July 28, 2021 |
| APPL NO | 17/387625 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0262 (20130101) H01L 21/02603 (20130101) Original (OR) Class H01L 21/02642 (20130101) H01L 21/02645 (20130101) H01L 29/0665 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230033452 | Brewer |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Micron Technology, Inc. (Boise, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tony M. Brewer (Plano, Texas) |
| ABSTRACT | A system includes multiple memory-compute nodes coupled to one another over a scale fabric, where each memory-compute node includes a hybrid threading processor; a memory controller; a fabric interface; and a network on chip (NOC) that provides communication between the hybrid threading processor, the fabric interface, and the memory controller, wherein the fabric interface supports a first virtual channel (VC0), and a second virtual channel (VC1) to the NOC, and supports the first virtual channel (VC0), the second virtual channel (VC1), and a third virtual channel (VC2) to the scale fabric. |
| FILED | Thursday, October 06, 2022 |
| APPL NO | 17/961229 |
| CURRENT CPC | Electric Digital Data Processing G06F 13/1668 (20130101) Original (OR) Class G06F 13/4027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230033475 | Lo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yu-Hwa Lo (San Diego, California); Jiayun Zhou (San Diego, California); Mohammad Abu Raihan Miah (La Jolla, California); Yong Zhang (La Jolla, California) |
| ABSTRACT | Methods, apparatus and systems are described that relate to uncooled long-wave infrared (LWIR) photodetectors capable of operating at room temperature and having a simple structure that can be manufactured at low cost. One example LWIR photodetector includes a layer of amorphous silicon (a-Si) disposed on a silicon substrate and a layer of amorphous germanium (a-Ge) disposed on the a-Si layer, wherein the a-Ge layer is operable to absorb infrared light and provide photoconductive gain, and the a-Si layer is operable to produce carrier multiplication via cycling excitation process. |
| FILED | Wednesday, November 25, 2020 |
| APPL NO | 17/780004 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/14649 (20130101) Original (OR) Class H01L 31/101 (20130101) H01L 31/0216 (20130101) H01L 31/03762 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230033526 | Wu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yuanpeng Wu (Ann Arbor, Michigan); Zetian Mi (Ann Arbor, Michigan) |
| ABSTRACT | A device includes a substrate, and a plurality of structures supported by the substrate, each structure of the plurality of structures including a Group III-nitride base, first and second Group III-nitride charge carrier injection layers supported by the Group III-nitride base, and a quantum heterostmcture disposed between the first and second charge carrier injection layers. The quantum hetero structure includes a pair of Group III-nitride barrier layers, and a Group III-nitride active layer disposed between the pair of Group III-nitride barrier layers. The Group III-nitride active layer has a thickness for quantum confinement of charge carriers. At least one of the pair of Group III-nitride barrier layers has a nitride surface adjacent to the Group III-nitride active layer. |
| FILED | Wednesday, December 23, 2020 |
| APPL NO | 17/788633 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 33/06 (20130101) Original (OR) Class H01L 33/007 (20130101) H01L 33/08 (20130101) H01L 33/24 (20130101) H01L 33/325 (20130101) H01L 2933/0016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230033788 | Tassev |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vladimir Tassev (Beavercreek, Ohio) |
| ABSTRACT | A method of performing heteroepitaxy comprises exposing a substrate to a carrier gas, a first precursor gas, a Group II/III element, and a second precursor gas, to form a heteroepitaxial growth of one of GaAs, AlAs, InAs, GaP, InP, ZnSe, GaSe, CdSe, InSe, ZnTe, CdTe, GaTe, HgTe, GaSb, InSb, AlSb, CdS, GaN, and AlN on the substrate; wherein the substrate comprises one of GaAs, AlAs, InAs, GaP, InP, ZnSe, GaSe, CdSe, InSe, ZnTe, CdTe, GaTe, HgTe, GaSb, InSb, AlSb, CdS, GaN, and AlN; wherein the carrier gas is Hz, wherein the first precursor is HCl, the Group II/III element comprises at least one of Zn, Cd, Hg, Al, Ga, and In; and wherein the second precursor is one of AsH3 (arsine), PH3 (phosphine), H2Se (hydrogen selenide), H2Te (hydrogen telluride), SbH3 (hydrogen antimonide), H2S (hydrogen sulfide), and NH3 (ammonia). The process may be an HVPE (hydride vapor phase epitaxy) process. |
| FILED | Tuesday, October 04, 2022 |
| APPL NO | 17/937787 |
| CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 25/04 (20130101) Original (OR) Class C30B 25/18 (20130101) C30B 29/42 (20130101) C30B 29/44 (20130101) C30B 29/48 (20130101) C30B 29/406 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/3556 (20130101) G02F 1/3558 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0254 (20130101) H01L 21/0262 (20130101) H01L 21/02293 (20130101) H01L 21/02389 (20130101) H01L 21/02392 (20130101) H01L 21/02395 (20130101) H01L 21/02398 (20130101) H01L 21/02458 (20130101) H01L 21/02461 (20130101) H01L 21/02463 (20130101) H01L 21/02466 (20130101) H01L 21/02505 (20130101) H01L 21/02543 (20130101) H01L 21/02546 (20130101) H01L 21/02549 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230033822 | Walker et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dean E. Walker (Allen, Texas); Tony Brewer (Plano, Texas) |
| ABSTRACT | A method includes setting an order of input-output channels of a column of a first chiplet of multiple chiplets of a chiplet-based system, wherein one or more of the multiple chiplets include field-configurable input-output channels arranged at a periphery of the chiplets; and programming a second chiplet of the multiple chiplets to change an order of input-output channels of a column of the second chiplet to match the order of input-output channels of the column of the first chiplet. |
| FILED | Friday, October 07, 2022 |
| APPL NO | 17/962253 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/30101 (20130101) G06F 13/1694 (20130101) Static Stores G11C 7/1006 (20130101) Original (OR) Class G11C 7/1069 (20130101) G11C 7/1096 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/5382 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230034610 | Piasecki et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Dragonfly Pictures, Inc. (Essington, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael W. Piasecki (Haverford, Pennsylvania); Joseph S. Pawelczyk, JR. (Philadelphia, Pennsylvania); Jeffrey Field (Springfield, Pennsylvania) |
| ABSTRACT | An unmanned aerial signal relay includes an unmanned aerial vehicle, including a communication relay unit and at least one antenna, communicatively connected to the communication relay unit; a tether comprising at least two wires and at least one fiber optic cable, the wires and cable communicatively connected to the unmanned aerial vehicle; and a surface support system comprising a spool physically connected to the tether and a ground-based receiver communicatively connected to the at least one fiber optic cable, wherein the unmanned aerial vehicle is powered by electrical energy provided by the at least two wires, and wherein the communication relay unit is configured to relay signals received from the at least one antenna via the fiber optic cable to the ground-based receiver. Various systems and methods related to an unmanned aerial signal relay are also described. |
| FILED | Friday, October 07, 2022 |
| APPL NO | 17/938751 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 39/022 (20130101) Original (OR) Class B64C 39/024 (20130101) B64C 2201/122 (20130101) B64C 2201/205 (20130101) Transmission H04B 10/2575 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230034642 | Chang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Oregon State University (Corvallis, Oregon) |
| ASSIGNEE(S) | Oregon State University (Corvallis, Oregon) |
| INVENTOR(S) | Chih-hung Chang (Corvallis, Oregon); Venkata Vinay Krishna Doddapaneni (Corvallis, Oregon); Yujuan He (Corvallis, Oregon); Jeffrey Dhas (Corvallis, Oregon); Brian K. Paul (Corvallis, Oregon); Somayeh Pasebani (Corvallis, Oregon); Chuankai Song (Corvallis, Oregon); Sakineh Abbasi (Corvallis, Oregon) |
| ABSTRACT | A print head comprising nested chambers for in-situ reactant formation is disclosed. The print head comprises a first chamber nested within a second chamber. The first chamber comprises a first nozzle, the second chamber comprises a second nozzle. The first nozzle is substantially coaxial with the second nozzle. A susceptor to convert electromagnetic energy to heat is within the first chamber. The susceptor comprises one or more openings extending between the upper portion and the lower portion. The susceptor may be heated by induction heating or by optical heating to vaporize a precursor substance within the first chamber. The vapor may react with a reactive gas flowing through the first chamber or expand through a nozzle into a second chamber where the vapor may react with the reactive gas, forming nanoparticles. Patterned films may be written onto a two-dimensional or three-dimensional surfaces. |
| FILED | Tuesday, July 26, 2022 |
| APPL NO | 17/814914 |
| CURRENT CPC | Spraying Apparatus; Atomising Apparatus; Nozzles B05B 1/28 (20130101) B05B 7/0075 (20130101) Processes for Applying Fluent Materials to Surfaces, in General B05D 1/12 (20130101) Original (OR) Class Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/118 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230034652 | ROSSI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | APG Cash Drawer, LLC (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anthony A. ROSSI (East Sussex, United Kingdom); Gianandrea MANFREDI (Brighton, United Kingdom) |
| ABSTRACT | A cash drawer is provided. The cash drawer includes a plurality of compartments configured to hold a plurality of objects. The cash drawer further includes a weight sensor coupled to each of the plurality of compartments, the weight sensor being configured to detect a weight change within a respective compartment and produce an output indicative of the detected weight change. The cash drawer further includes a processor configured to receive the output from the weight sensor and determine an object count based on the detected weight change within the respective compartment. |
| FILED | Thursday, July 28, 2022 |
| APPL NO | 17/875685 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 20/208 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230034750 | Piasecki et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Dragonfly Pictures, Inc. (Essington, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael W. Piasecki (Haverford, Pennsylvania); Joseph S. Pawelczyk, Jr. (Philadelphia, Pennsylvania); Jeffrey Field (Springfield, Pennsylvania) |
| ABSTRACT | An unmanned aerial signal relay includes an unmanned aerial vehicle, including a communication relay unit and at least one antenna, communicatively connected to the communication relay unit; a tether comprising at least two wires and at least one fiber optic cable, the wires and cable communicatively connected to the unmanned aerial vehicle; and a surface support system comprising a spool physically connected to the tether and a ground-based receiver communicatively connected to the at least one fiber optic cable, wherein the unmanned aerial vehicle is powered by electrical energy provided by the at least two wires, and wherein the communication relay unit is configured to relay signals received from the at least one antenna via the fiber optic cable to the ground-based receiver. Various systems and methods related to an unmanned aerial signal relay are also described. |
| FILED | Friday, October 07, 2022 |
| APPL NO | 17/938754 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 39/022 (20130101) Original (OR) Class B64C 39/024 (20130101) B64C 2201/122 (20130101) B64C 2201/205 (20130101) Transmission H04B 10/2575 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230034904 | Missaghi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF HAWAI'I (Honolulu, Hawaii) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Baseem Missaghi (Honolulu, Hawaii); Noah Hafner (Honolulu, Hawaii) |
| ABSTRACT | A system for sensing maritime position and visualization includes an imaging device configured to capture an image including a vessel, a receiver configured to receive a first geospatial position of a user device and/or a compass heading of the user device, an Automatic Identification System (AIS) receiver configured to receive an AIS message, a processor, and a memory. The AIS message includes a second geospatial position of the vessel. The memory includes instructions, which, when executed by the processor, cause the system to capture an image of the vessel, receive a position and a heading of the user device, receive the AIS message, match the vessel in the captured image with the vessel identifier and the second geospatial position of the vessel of the AIS message, and generate an augmented reality marker based on the vessel identifier and the second geospatial position of the vessel of the AIS message. |
| FILED | Wednesday, July 27, 2022 |
| APPL NO | 17/874487 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 19/13 (20130101) Optical Elements, Systems, or Apparatus G02B 27/0101 (20130101) Image Data Processing or Generation, in General G06T 11/001 (20130101) Original (OR) Class Traffic Control Systems G08G 3/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230035253 | Girton et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Damon Girton (Terre Haute, Indiana); Johnathan McAllister (Washington, District of Columbia); Matthew Scharf (Fairborn, Ohio); Matthew Seymour (Springboro, Ohio); Peter Voland (Beavercreek, Ohio); Matthew Stechschulte (Waynesville, Ohio); Nathan Stover (Xenia, Ohio) |
| ABSTRACT | A voice communication relay device for use in combination with a protective face mask having an embedded microphone, a headset, a radio, and a push-to-talk (PTT) device that is connected to a radio. The voice communication relay device includes: a housing; a device speaker associated with the housing; an amplifier in the housing, the amplifier being electrically connected to the device speaker; a circuit board located inside of the housing; and a power source. At least one function of the circuit board is to serve as an Impedance dependent auto switch (IDAS) that is electrically connected to the device speaker and an output connector for selectively sending signals to the device speaker or to a radio that is connected to the PTT device. |
| FILED | Thursday, June 30, 2022 |
| APPL NO | 17/854002 |
| CURRENT CPC | Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 1/083 (20130101) Original (OR) Class H04R 1/1041 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230035372 | Reid et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | David Reid (Cocoa, Florida); Michael Fisher (Springboro, Ohio); Catherine Anne Marie Dillier (Belcamp, Maryland); Andrew Robert Demko (Ridgecrest, California); Eric L. Petersen (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Reid (Cocoa, Florida); Michael Fisher (Springboro, Ohio); Catherine Anne Marie Dillier (Belcamp, Maryland); Andrew Robert Demko (Ridgecrest, California); Eric L. Petersen (College Station, Texas) |
| ABSTRACT | The present invention is a composite solid propellant designed to operate in three distinct combustion regimes under various pressure states in the combustion chamber of a solid rocket motor. The design of this propellant facilitates desirable rocket motor operational characteristics, including throttleability, extinguishment, and self-destruction or detonability. The propellant contains ingredients that modify the propellant combustion characteristics to provide the desired behavior, including a surfactant and unaggregated, unagglomerated dispersed primary nanoparticles of aluminum in a polymer binder. |
| FILED | Tuesday, May 10, 2022 |
| APPL NO | 17/740520 |
| CURRENT CPC | Explosives or Thermic Compositions; Manufacture Thereof; Use of Single Substances as Explosives C06B 33/02 (20130101) C06B 45/08 (20130101) C06B 45/10 (20130101) Jet-propulsion Plants F02K 9/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230035677 | Ruck et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Textron Systems Corporation (Hunt Valley, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joshua Stephen Ruck (Baltimore, Maryland); Brandon Scott Recchia (Parkton, Maryland); Bradford Timothy Jones (Baltimore, Maryland); Benjamin Tyler Cole (Baltimore, Maryland); Petro Romanovych Khoma (Bel Air, Maryland); Mark Timothy Fellows (Towson, Maryland); Madeline Claire Spurlock (Baltimore, Maryland) |
| ABSTRACT | A weapon is capable of firing cased telescoped (CT) ammunition rounds. The weapon includes a barrel, a chamber member that defines a chamber configured to hold a CT round for firing from the weapon, a non-rotating carrier body, and linkage. The linkage is constructed and arranged to move the chamber member (i) from a firing position in which the chamber member is aligned with the barrel for firing the CT round to an ejection/loading position in which the chamber member is not aligned with the barrel for ejecting a spent CT round and receiving a next CT round in response to the non-rotating carrier body moving away from the barrel, and (ii) from the ejection/loading position to the firing position in response to the non-rotating carrier body moving toward the barrel. |
| FILED | Wednesday, February 09, 2022 |
| APPL NO | 17/668126 |
| CURRENT CPC | Functional Features or Details Common to Both Smallarms and Ordnance, e.g Cannons; Mountings for Smallarms or Ordnance F41A 3/10 (20130101) F41A 9/45 (20130101) Original (OR) Class F41A 15/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230035859 | Bruno et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter M. Bruno (Brookline, Massachusetts); Stephen J. Elledge (Brookline, Massachusetts) |
| ABSTRACT | Described herein are methods for identification of peptides that bind MHC-I molecules from within a starting pool of candidate epitope peptides, using a cell-based genetic immunopeptidomic screen. |
| FILED | Wednesday, December 02, 2020 |
| APPL NO | 17/780407 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) C07K 14/70539 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/00 (20130101) C12N 15/86 (20130101) C12N 15/625 (20130101) C12N 15/1037 (20130101) C12N 15/1138 (20130101) Original (OR) Class C12N 2740/15043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230036562 | Broadfoot et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | USA as represented by the Secretary of the Army (Washington, District of Columbia) |
| ASSIGNEE(S) | United States of America as represented by the Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | Meredith B. Broadfoot (Madison, Alabama); Earl W. Thomas (Madison, Alabama) |
| ABSTRACT | The present disclosure provides a load-bearing composite platform. The platform includes a core layer, first and second reinforcement layers, and a frame. The core layer includes a structural sublayer, a force distribution sublayer, and an abrasion prevention sublayer. The first reinforcement layer is adhered to the force distribution sublayer, and the second reinforcement layer is adhered to the structural sublayer. The second reinforcement layer is an inverse of the first reinforcement layer. The frame surrounds the first reinforcement layer, the second reinforcement layer, and the core layer. |
| FILED | Friday, July 30, 2021 |
| APPL NO | 17/390421 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 3/12 (20130101) B32B 5/265 (20210501) Original (OR) Class B32B 7/12 (20130101) B32B 27/12 (20130101) B32B 2255/26 (20130101) B32B 2262/106 (20130101) B32B 2307/744 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230036709 | Shin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Jong-Dug Shin (Austin, Texas); Ray T. Chen (Austin, Texas); Jason Midkiff (Austin, Texas) |
| ASSIGNEE(S) | Omega Optics, Inc. (Austin, Texas) |
| INVENTOR(S) | Jong-Dug Shin (Austin, Texas); Ray T. Chen (Austin, Texas); Jason Midkiff (Austin, Texas) |
| ABSTRACT | A novel, monolithically integrated mid-IR optical phased array (OPA) structure which eliminates the wafer bonding process to achieve highly efficient surface emitting optical beam steering in two dimensions is disclosed. Since solar energy is about 15-20 times smaller than that at 1.55 um, mid-IR is more favorable for the atmospheric transmission due to lower solar radiance backgrounds. For the beam steering, thermo-optic phase shifting is used for azimuthal plane beam steering and laser wavelength tuning is used for elevation plane beam steering. The OPA structure disclosed comprises a wavelength- tunable a QCL, a 1×32 splitter, thermo-optic phase-shifters, and sub-wavelength grating emitters. The disclosed OPA provides a low-cost, low-loss, low-power consumption, robust, small footprint, apparatus that may be used with expendable UAV swarms. A LiDAR may be created by monolithically integrating a QCD with the apparatus. Other embodiments are described and claimed. |
| FILED | Monday, November 09, 2020 |
| APPL NO | 17/093612 |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/1007 (20130101) H01S 5/1246 (20130101) Original (OR) Class H01S 5/3401 (20130101) H01S 5/34346 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20230029633 | Signorelli et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | FastCAP Systems Corporation (Wakefield, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Riccardo Signorelli (Boston, Massachusetts); John J. Cooley (Boston, Massachusetts); Christopher John Sibbald Deane (Boston, Massachusetts); James Epstein (Sharon, Massachusetts); Padmanaban Sasthan Kuttipillai (Malden, Massachusetts); Fabrizio Martini (Boston, Massachusetts); Lindsay A. Wilhelmus (Lexington, Kentucky) |
| ABSTRACT | Disclosed herein is a method for fabricating an ultracapacitor, the method comprising disposing an energy storage cell comprising energy storage media within a housing; and constructing the ultracapacitor to operate within a temperature range between about 80 degrees Celsius to about 210 degrees Celsius. |
| FILED | Tuesday, September 20, 2022 |
| APPL NO | 17/948585 |
| CURRENT CPC | Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/14 (20130101) Original (OR) Class H01G 11/18 (20130101) H01G 11/32 (20130101) H01G 11/58 (20130101) H01G 11/60 (20130101) H01G 11/78 (20130101) H01G 11/84 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/13 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230029649 | Wilson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas S. Wilson (Castro Valley, California); Jane P. Bearinger (Berwyn, Pennsylvania) |
| ABSTRACT | New shape memory polymer compositions, methods for synthesizing new shape memory polymers, and apparatus comprising an actuator and a shape memory polymer wherein the shape memory polymer comprises at least a portion of the actuator. A shape memory polymer comprising a polymer composition which physically forms a network structure wherein the polymer composition has shape-memory behavior and can be formed into a permanent primary shape, re-formed into a stable secondary shape, and controllably actuated to recover the permanent primary shape. Polymers have optimal aliphatic network structures due to minimization of dangling Chains by using monomers that are symmetrical and that have matching amine and hydroxl groups providing polymers and polymer foams with clarity, tight (narrow temperature range) single transitions, and high shape recovery and recovery force that are especially useful for implanting in the human body. |
| FILED | Thursday, September 22, 2022 |
| APPL NO | 17/950731 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/3498 (20130101) A61B 2017/00867 (20130101) A61B 2017/00871 (20130101) A61B 2017/2932 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/08 (20130101) C08G 18/73 (20130101) C08G 18/3203 (20130101) Original (OR) Class C08G 18/3221 (20130101) C08G 18/3271 (20130101) C08G 18/3281 (20130101) C08G 18/3284 (20130101) C08G 18/3287 (20130101) C08G 18/3851 (20130101) C08G 2280/00 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 9/0085 (20130101) Compositions of Macromolecular Compounds C08L 75/04 (20130101) C08L 75/12 (20130101) C08L 75/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230030182 | YADAV et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gautam G. YADAV (New York, New York); Xia WEI (New York, New York); Joshua GALLAWAY (New York, New York); Michael NYCE (New York, New York); Sanjoy BANERJEE (New York, New York) |
| ABSTRACT | A battery comprises a housing, an electrolyte disposed in the housing, a cathode disposed in the housing, an anode disposed in the housing and comprising an anode material comprising: zinc or zinc oxide, an electrocoagulant material selected from the group consisting of: aluminum, iron, titanium, calcium, zirconium, a hydroxide thereof, a salt thereof, an oxide thereof, and a combination thereof, and a binder. |
| FILED | Friday, January 22, 2021 |
| APPL NO | 17/788822 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/244 (20130101) H01M 4/628 (20130101) Original (OR) Class H01M 2004/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230030401 | Mehta et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Apurva Mehta (MENLO PARK, California); SUCHISMITA SARKER (MENLO PARK, California); CORINNE E. PACKARD (LAKEWOOD, Colorado); RACHEL SCHOEPPNER (SANTA BARBARA, California) |
| ABSTRACT | A metallic glass coating material is composed of an alloy of Fe, B, and one of the metals Nb, Mo, Zr, or W. The ratios of Fe, B, and the metal are predetermined using machine learning predictions and high-throughput experiments. In one example, the material is an alloy of Fe, Nb, Mo and B, of the form Fex(Nb, Mo)yBz, where x is in the range 18-28, y is in the range 35-45, and z is in the range 32-42. In another example, the material may be the alloy Fe23(Nb, Mo)40B37. The alloy may be doped with Zr and/or W, where the Zr and/or W comprises at most 10% of the alloy. |
| FILED | Wednesday, July 20, 2022 |
| APPL NO | 17/869720 |
| CURRENT CPC | Alloys C22C 45/02 (20130101) Original (OR) Class C22C 2200/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230030468 | Wilson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas S. Wilson (Castro Valley, California); Jane P. Bearinger (Berwyn, Pennsylvania) |
| ABSTRACT | New shape memory polymer compositions, methods for synthesizing new shape memory polymers, and apparatus comprising an actuator and a shape memory polymer wherein the shape memory polymer comprises at least a portion of the actuator. A shape memory polymer comprising a polymer composition which physically forms a network structure wherein the polymer composition has shape-memory behavior and can be formed into a permanent primary shape, re-formed into a stable secondary shape, and controllably actuated to recover the permanent primary shape. Polymers have optimal aliphatic network structures due to minimization of dangling chains by using monomers that are symmetrical and that have matching amine and hydroxl groups providing polymers and polymer foams with clarity, tight (narrow temperature range) single transitions, and high shape recovery and recovery force that are especially useful for implanting in the human body. |
| FILED | Thursday, September 22, 2022 |
| APPL NO | 17/950623 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/3498 (20130101) A61B 2017/00867 (20130101) A61B 2017/00871 (20130101) A61B 2017/2932 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/08 (20130101) C08G 18/73 (20130101) C08G 18/3203 (20130101) Original (OR) Class C08G 18/3221 (20130101) C08G 18/3271 (20130101) C08G 18/3281 (20130101) C08G 18/3284 (20130101) C08G 18/3287 (20130101) C08G 18/3851 (20130101) C08G 2280/00 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 9/0085 (20130101) Compositions of Macromolecular Compounds C08L 75/04 (20130101) C08L 75/12 (20130101) C08L 75/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230030783 | Urick et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | nVariate, Inc. (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin Urick (Roseville, California); Richard H. Crawford (Austin, Texas); Daniel L. Keller (Waitsfield, Vermont) |
| ABSTRACT | Methods and computer systems for utilizing gapless surface models in computer-aided design (CAD) applications to produce printing instructions for additive manufacturing (AM). A geometrically watertight CAD spline model of an object to be printed is received. For of a plurality of AM layers of the object, an intersection routine is performed of a plane of the layer with the geometrically watertight CAD spline model to obtain a respective smooth contour curve. For each AM layer, a plurality of hatch curves is determined within the plane of the layer and interior to the respective smooth contour curve. The smooth contour curves and the pluralities of hatch curves are stored in a non-transitory computer-readable memory medium. |
| FILED | Friday, July 15, 2022 |
| APPL NO | 17/865863 |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/4099 (20130101) Original (OR) Class Electric Digital Data Processing G06F 30/10 (20200101) G06F 2113/10 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230030912 | Estrada et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Fermi Research Alliance, LLC (Balavia, Illinois) |
| ASSIGNEE(S) | Fermi Research Alliance, LLC (Batavia, Illinois) |
| INVENTOR(S) | Juan Estrada (Geneva, Illinois); Guillermo Fernandez Moroni (Batavia, Illinois); Andrew G. Lathrop (Bristol, Illinois); Javier Tiffenberg (Chicago, Illinois) |
| ABSTRACT | Systems, methods, and apparatus that employ a connector assembly having a substrate layer with an inner aperture and an outer periphery, and one or more signal traces disposed on the substrate that extend from an inner first location to an outer second location of the apparatus, for communicating data between electronic devices positioned within an interior volume of an enclosed vessel and complementary electronic devices positioned in an ambient environment external to the enclosed vessel. An inner connector is conductively connected the signal traces at the inner first location of each signal trace, and an outer connector is conductively connected to the one or more signal traces at the outer second location of each signal trace. A substantially flat exterior surface extends radially over at least a portion of a region between the respective first locations and the respective second locations. |
| FILED | Thursday, July 29, 2021 |
| APPL NO | 17/389306 |
| CURRENT CPC | Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors H01R 13/6215 (20130101) H01R 43/26 (20130101) H01R 43/205 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/18 (20130101) Original (OR) Class H05K 1/0216 (20130101) H05K 3/282 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230030959 | Shi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Jiayan Shi (Woodridge, Illinois); Khalil Amine (Woodridge, Illinois); Chi Cheung Su (Westmont, Illinois); Rachid Amine (Bolingbrook, Illinois) |
| ABSTRACT | Methods of applying as-prepared alkaline source materials for a secondary battery. The cathode includes an alkaline source material with or without coating including an alkali metal oxide, an alkali metal sulfide, an alkali metal salt, or a combination of any two or more thereof. An as-prepared spread coating layer for a secondary battery, the coating layer includes an alkaline source material, including an alkali metal oxide, an alkali metal sulfide, and an alkali metal salt, with or without coating, a conductive carbon, a catalyst, or a combination of any two or more thereof. An as-prepared electrolyte for a secondary battery, the electrolyte includes an alkaline source material including an alkali metal oxide, an alkali metal sulfide, an alkali metal salt, or a combination of any two or more thereof. |
| FILED | Friday, July 30, 2021 |
| APPL NO | 17/389762 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/364 (20130101) H01M 4/387 (20130101) H01M 4/0402 (20130101) H01M 4/485 (20130101) H01M 4/583 (20130101) H01M 4/5815 (20130101) Original (OR) Class H01M 10/0569 (20130101) H01M 2300/0042 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230032172 | Zuo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (Blacksburg, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lei Zuo (Blacksburg, Virginia); Robert Parker (Salt Lake City, Utah); Xiaofan Li (Blacksburg, Virginia) |
| ABSTRACT | Various examples of simultaneous ocean wave and current energy harvesting are described, using a hybrid ocean energy converter and a mechanical transfer system therefor. In one example, a hybrid ocean energy converter includes a two-body point absorber comprising a first body and a second body. The two-body point absorber can be configured to transfer a linear relative motion between the first body and the second body to bi-directional rotation of a first input shaft. A turbine can be configured rotate a second input shaft. The converter further includes a hybrid power takeoff including a mechanical transfer system configured to mechanically couple the first input shaft, the second input shaft, an output shaft, and an output shaft. |
| FILED | Wednesday, January 13, 2021 |
| APPL NO | 17/784187 |
| CURRENT CPC | Machines or Engines for Liquids F03B 13/16 (20130101) Original (OR) Class F03B 13/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230033147 | Huang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of South Carolin (Columbia, South Carolina) |
| ASSIGNEE(S) | University of South Carolina (Columbia, South Carolina) |
| INVENTOR(S) | Kevin Huang (Columbia, South Carolina); Xin Yang (Richland, Washington) |
| ABSTRACT | Described herein are new solid oxide fuel cell interconnects and methods for making same that may comprise a novel bilayer construct on an anode substrate to provide a dense microstructure, low area specific resistance, and negligible oxygen permeability to form a bilayer ceramic interconnect that is a strong candidate for next-generation, durable, and low-cost tubular solid oxide fuel cells. |
| FILED | Thursday, May 26, 2022 |
| APPL NO | 17/824975 |
| CURRENT CPC | Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 33/006 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/8621 (20130101) H01M 8/243 (20130101) Original (OR) Class H01M 8/2465 (20130101) H01M 2008/1293 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230033275 | LYNCH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CARGILL, INCORPORATED (Wayzata, Minnesota) |
| ASSIGNEE(S) | CARGILL, INCORPORATED (Wayzata, Minnesota) |
| INVENTOR(S) | Michael D. LYNCH (Durham, North Carolina); Michael Tai Man LOUIE (Plymouth, Minnesota); Shelley COPLEY (Boulder, Colorado); Eileen Colie SPINDLER (Lafayette, Colorado); Brittany ROBINSON (Wheat Ridge, Colorado); Matthew LIPSCOMB (Boulder, Colorado); Tanya LIPSCOMB-WARNECKE (Boulder, Colorado); Hans H. LIAO (Plymouth, Minnesota); David HOGSETT (Niwot, Colorado); Ron EVANS (Louisville, Colorado) |
| ABSTRACT | This invention relates to metabolically engineered microorganism strains, such as bacterial strains, in which there is an increased utilization of malonyl-CoA for production of a fatty acid or fatty acid derived product, wherein the modified microorganism produces fatty acyl-CoA intermediates via a malonyl-CoA dependent but malonyl-ACP independent mechanism. |
| FILED | Wednesday, June 29, 2022 |
| APPL NO | 17/809750 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 9/001 (20130101) C12N 9/0006 (20130101) C12N 9/88 (20130101) C12N 9/1029 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/6409 (20130101) Original (OR) Class Enzymes C12Y 101/01035 (20130101) C12Y 103/01093 (20150701) C12Y 203/01194 (20130101) C12Y 402/01059 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230033430 | Bai et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yaocai Bai (Oak Ridge, Tennessee); Ilias Belharouak (Oak Ridge, Tennessee); Rachid Essehli (Oak Ridge, Tennessee) |
| ABSTRACT | An improved method of recycling lithium-ion battery anode scraps is provided. The method involves isolating an anode scrap including a graphite anode film adhered to a current collector foil with a polyvinylidene fluoride binder. The anode scrap is combined with deionized water to form a first mixture. The graphite anode film is delaminated from the current collector foil to form a second mixture comprising a free collector foil and a free graphite anode film. The free graphite anode film is filtered and dried from the second mixture to recover the free graphite anode film. The free graphite anode film is combined with a solvent comprising N-methyl-2-pyrrolidone (NMP) to form an anode formation slurry. The slurry is coated onto a copper current collector to produce a new anode. |
| FILED | Wednesday, July 28, 2021 |
| APPL NO | 17/386660 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/133 (20130101) H01M 4/583 (20130101) H01M 4/623 (20130101) H01M 4/662 (20130101) H01M 10/54 (20130101) Original (OR) Class H01M 10/0525 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230033524 | Wu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Junqiao Wu (Kensington, California); Kechao Tang (Berkeley, California) |
| ABSTRACT | A material platform with controllable emissivity and fabrication methods are provided that permit the manipulation of thermal radiation detection and IR signal modulation and can be adapted to a variety of uses including infrared camouflage, thermal IR decoys, thermo-reflectance imaging and IR signal modulation. The platform is a multilayer WxV1-xO2 film with different W doping levels (x values) and layer thicknesses, forming a graded W-doped construct. In WVO2 films with a total thickness <100 nm, the graded doping of W spreads the originally sharp metal-insulator phase transition (MIT) to a broad temperature range, greatly expanding the temperature window for emissivity modulation. |
| FILED | Thursday, August 04, 2022 |
| APPL NO | 17/817475 |
| CURRENT CPC | Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials C03C 3/122 (20130101) Original (OR) Class C03C 4/082 (20130101) C03C 17/3417 (20130101) C03C 23/007 (20130101) C03C 2203/52 (20130101) C03C 2217/24 (20130101) C03C 2218/328 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230033611 | Small et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Leo J. Small (Albuquerque, New Mexico); Melissa Lynn Meyerson (Albuquerque, New Mexico) |
| ABSTRACT | The invention is directed to a mediated metal-sulfur flow battery. This battery format that is readily scalable to grid-scale levels at low cost, while maintaining battery safety by physically separating the anode and cathode. As an example, the marriage of a redox-targeting scheme to an engineered Li solid electrolyte interphase (SEI) enables a scalable, high efficiency, membrane-less Li—S redox flow battery. Redox mediators can be sued to kick-start the initial reduction of solid S into soluble polysulfides on the cathode side and final reduction of polysulfides into solid Li2S, precluding the need for conductive carbons. On the anode side, a LiI and LiNO3 pretreatment and additive strategy encourages a stable SEI and lessens capacity fade, avoiding the need for ion-selective separators. |
| FILED | Monday, May 09, 2022 |
| APPL NO | 17/740128 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/188 (20130101) Original (OR) Class H01M 10/0525 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230034642 | Chang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Oregon State University (Corvallis, Oregon) |
| ASSIGNEE(S) | Oregon State University (Corvallis, Oregon) |
| INVENTOR(S) | Chih-hung Chang (Corvallis, Oregon); Venkata Vinay Krishna Doddapaneni (Corvallis, Oregon); Yujuan He (Corvallis, Oregon); Jeffrey Dhas (Corvallis, Oregon); Brian K. Paul (Corvallis, Oregon); Somayeh Pasebani (Corvallis, Oregon); Chuankai Song (Corvallis, Oregon); Sakineh Abbasi (Corvallis, Oregon) |
| ABSTRACT | A print head comprising nested chambers for in-situ reactant formation is disclosed. The print head comprises a first chamber nested within a second chamber. The first chamber comprises a first nozzle, the second chamber comprises a second nozzle. The first nozzle is substantially coaxial with the second nozzle. A susceptor to convert electromagnetic energy to heat is within the first chamber. The susceptor comprises one or more openings extending between the upper portion and the lower portion. The susceptor may be heated by induction heating or by optical heating to vaporize a precursor substance within the first chamber. The vapor may react with a reactive gas flowing through the first chamber or expand through a nozzle into a second chamber where the vapor may react with the reactive gas, forming nanoparticles. Patterned films may be written onto a two-dimensional or three-dimensional surfaces. |
| FILED | Tuesday, July 26, 2022 |
| APPL NO | 17/814914 |
| CURRENT CPC | Spraying Apparatus; Atomising Apparatus; Nozzles B05B 1/28 (20130101) B05B 7/0075 (20130101) Processes for Applying Fluent Materials to Surfaces, in General B05D 1/12 (20130101) Original (OR) Class Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/118 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230034644 | CUI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Yi CUI (Stanford, California); Jiayu WAN (Stanford, California); Yi CUI (Stanford, California); Yusheng YE (Stanford, California) |
| ABSTRACT | Embodiments of the present disclosure include solid-state electrolytes comprising a porous host and solid polymer electrolyte fillers dispersed within pores of the porous host. Further embodiments include batteries comprising an anode, a cathode, and a solid-state electrolyte of the disclosure disposed between the anode and the cathode. |
| FILED | Wednesday, December 23, 2020 |
| APPL NO | 17/788274 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0565 (20130101) Original (OR) Class H01M 2004/027 (20130101) H01M 2300/0082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230035291 | Suski |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Applied Engineering Concepts, Inc. (Eldersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William Charles Suski (Mount Pleasant, South Carolina) |
| ABSTRACT | Systems and methods for computing device authentication can involve template matching with an authentication filter. Authentication filters can be generated by using an authentication model to determine or generate templates for authenticated classes. For example, simulated signal data sets can be input into the authentication model until an authenticated class classification is output. The successful simulated signal data set may then be used to generate or update an authentication filter that uses the template for template matching authentication classification. |
| FILED | Friday, May 27, 2022 |
| APPL NO | 17/826654 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/31 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230035800 | Sharon et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Collins Engine Nozzles, Inc. (Des Moines, Iowa) |
| ASSIGNEE(S) | Collins Engine Nozzles, Inc. (Des Moines, Iowa) |
| INVENTOR(S) | John A. Sharon (West Hartford, Connecticut); Ying She (East Hartford, Connecticut); Tahany I. El-Wardany (Vernon, Connecticut); Wayde R. Schmidt (Pomfret Center, Connecticut) |
| ABSTRACT | A particulate for an additive manufacturing technique includes a particulate body formed from a particulate material and a coating disposed over particulate body. The coating includes a carbonaceous material that has a reflectivity that is lower than a reflectivity of the particulate material to reduce an energy input requirement of the particulate such that less energy is necessary to fuse the particulate into a layer of an article fabricated using the additive manufacturing technique. A method of making particulate is also disclosed. |
| FILED | Wednesday, August 10, 2022 |
| APPL NO | 17/885153 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/16 (20220101) B22F 10/20 (20210101) Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 15/0086 (20130101) B23K 26/342 (20151001) B23K 35/00 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) B33Y 70/10 (20200101) B33Y 80/00 (20141201) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 5/14 (20130101) Original (OR) Class Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/26 (20130101) C23C 16/442 (20130101) C23C 16/4417 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 10/25 (20151101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230036175 | Arnold et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin); The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Arnold (Middleton, Wisconsin); Robert Jacobberger (Madison, Wisconsin); Paul F. Nealey (Chicago, Illinois); Shisheng Xiong (Darien, Illinois); Tzu-Hsuan Chang (Madison, Wisconsin); Zhenqiang Ma (Middleton, Wisconsin) |
| ABSTRACT | Methods of spatially directing the orientation and placement of multiple block copolymer (BCP) domains on isolated regions of a substrate are described. The methods involve epitaxially directing the assembly of BCP domains using spatial boundaries between regions with different surface composition, formed at the edges of isolated chemical regions on a background chemistry. Multiple vertical domains of BCP order on the isolated region, self-aligned in a direction parallel to edges of the isolated region. In some embodiments, vertical domains order on multiple isolated regions of a first chemistry of a chemical contrast pattern with horizontal domains on the regions of a second (background) chemistry of the chemical contrast pattern. Also provided herein are compositions resulting from the methods. |
| FILED | Tuesday, December 22, 2020 |
| APPL NO | 17/757887 |
| CURRENT CPC | Compositions of Macromolecular Compounds C08L 53/00 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 153/00 (20130101) Original (OR) Class Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/11 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0271 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230036244 | Huang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Zhuojun Huang (Stanford, California); Jiancheng Lai (Mountain View, California); Zhenan Bao (Stanford, California); Yi Cui (Stanford, California) |
| ABSTRACT | The present embodiments relate to lithium-based batteries, and particularly to coordinated solvent molecules that can increase the ionic conductivity of the electrolyte without undermining its non-flammability. Some embodiments include a liquid-state polymer electrolyte composed of LiFSI salts, Dimethoxyethane (DME) solvents, and polysiloxane tethered with ion solvating moieties. DME coordinates with both the salt and the polymer, while together with the salt, they synergistically plasticize the polymer to increase the ionic conductivity. The resulting non-flammable polymer electrolyte has a room temperature ionic conductivity of 1.6 mS/cm and a wide operation window of 25-100° C. Benefiting from its liquid nature, the electrolyte can pair with commercially available electrodes without further cell engineering. Embodiments can extend the ionic conductivity range of polymer electrolytes and provide a new design pathway for next generation safe and manufacturable electrolytes. |
| FILED | Friday, July 08, 2022 |
| APPL NO | 17/861081 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0525 (20130101) H01M 10/0565 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230036331 | LAHODA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Westinghouse Electric Company LLC (Cranberry Township, Pennsylvania) |
| ASSIGNEE(S) | Westinghouse Electric Company LLC (Cranberry Township, Pennsylvania) |
| INVENTOR(S) | Edward J. LAHODA (Edgewood, Pennsylvania); Clinton B. ARMSTRONG (Slippery Rock, Pennsylvania); Lyman J. PETROSKY (Latrobe, Pennsylvania) |
| ABSTRACT | A nuclear fuel assembly and a method of manufacture thereof are provided. The method comprises depositing a thermally conductive layer onto at least a portion of at least two nuclear fuel layers to create at least two at least partially coated layers. The method comprises stacking the at least two coated layers and bonding the at least two coated layers to form a nuclear fuel assembly. |
| FILED | Friday, January 08, 2021 |
| APPL NO | 17/758443 |
| CURRENT CPC | Nuclear Reactors G21C 3/18 (20130101) G21C 3/20 (20130101) Original (OR) Class G21C 3/36 (20130101) G21C 21/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230036493 | Sustarich et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jess Sustarich (San Francisco, California); Anup K. Singh (Danville, California); Lauren Washburn (Albuquerque, New Mexico); William Gaillard (Walnut Creek, California) |
| ABSTRACT | The present disclosure relates to a high throughput, scalable system for electroporation of biological cells. The two part system comprises an electroporation reaction array that interfaces with a control unit, providing electrical pulse, temperature control, and mixing of the sample contents. The control unit automates the entire process; electroporation, cell recovery and outgrowth are performed in a electroporation array assembly. The bottom of each reaction well of the electroporation array assembly contains a pair of coplanar electrodes. The bottom surface containing the electrodes is treated in a way to render it hydrophilic. This results in increased wetting of the electrodes thereby increasing transformation efficiency. The electrode configuration allows for processing of smaller sample volumes, reducing the consumption of expensive biological reagents by several orders of magnitude compared to conventional cuvette-based electroporation devices. |
| FILED | Friday, July 29, 2022 |
| APPL NO | 17/877043 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 35/02 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 13/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1468 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230036570 | Al Rashdan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho); Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ahmad Y. Al Rashdan (Salt Lake City, Utah); Hany S. Abdel-Khalik (Idaho Falls, Idaho) |
| ABSTRACT | Systems, apparatuses, and methods for deceptive infusion and obfuscation of data are disclosed. An apparatus including a communication terminal and a processing circuitry. The communication terminal is configured to transmit information to an artificial intelligence engine. The processing circuitry is configured to decompose raw data into fundamental metadata and inference metadata. The processing circuitry is also configured to generate one or more concealment operators and generate a deception kernel responsive to the inference metadata, the one or more concealment operators, and/or the fundamental metadata. The processing circuitry is configured to obfuscate the fundamental metadata responsive to the one or more concealment operators and the deception kernel, and provide the obfuscated fundamental metadata and the inference metadata to the artificial intelligence engine for processing. |
| FILED | Thursday, July 28, 2022 |
| APPL NO | 17/815876 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 5/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230036843 | Razeghi-Jahromi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ABB Schweiz AG (Baden, Switzerland) |
| ASSIGNEE(S) | ABB Schweiz AG (Baden, Switzerland) |
| INVENTOR(S) | Mohammad Razeghi-Jahromi (Cary, North Carolina); David Lee Coats (Apex, North Carolina); James D. Stoupis (Raleigh, North Carolina) |
| ABSTRACT | A method for recovering missing phase measurement unit (PMU) measurements from a plurality of PMUs is provided. The method comprises: receiving a plurality of obtained PMU measurements from the plurality of PMUs; populating a PMU dataset based on the plurality of obtained PMU measurements; determining a plurality of missing entries within the PMU dataset, wherein each of the plurality of missing entries indicates a missing PMU measurement within the PMU dataset at a particular time; determining a plurality of substitute entries for the plurality of missing entries based on an optimization algorithm that determines differences associated with a missing entry, of the plurality of missing entries, and a first set of PMU measurements, of the plurality of obtained PMU measurements, that are taken immediately prior to the missing entry; and inserting the plurality of substitute entries into the PMU dataset to generate a new PMU dataset. |
| FILED | Thursday, July 22, 2021 |
| APPL NO | 17/382578 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 25/00 (20130101) Electric Digital Data Processing G06F 16/2379 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20230029519 | WANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhiyuan WANG (Lebanon, New Hampshire); Xiaoxin WANG (Hanover, New Hampshire); Jifeng LIU (Hanover, New Hampshire) |
| ABSTRACT | Disclosed are infrared (IR) light detectors. The detectors operate by generating hot electrons in a metallic absorber layer on photon absorption, the electrons being transported through an energy barrier of an insulating layer to a metal or semiconductor conductive layer. The energy barrier is set to bar response to wavelengths longer than a maximum wavelength. Particular embodiments also have a pattern of metallic shapes above the metallic absorber layer that act to increase photon absorption while reflecting photons of short wavelengths; these particular embodiments have a band-pass response. |
| FILED | Monday, October 03, 2022 |
| APPL NO | 17/958868 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/146 (20130101) H01L 27/1446 (20130101) H01L 27/14875 (20130101) H01L 31/119 (20130101) Original (OR) Class H01L 31/02327 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230031122 | Ong et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Keat Ghee Ong (Eugene, Oregon); Robert E. Guldberg (Eugene, Oregon); William Skinner (Eugene, Oregon); Salil S. Karipott (Eugene, Oregon); University of Oregon (Eugene, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Keat Ghee Ong (Eugene, Oregon); Robert E. Guldberg (Eugene, Oregon); William Skinner (Eugene, Oregon); Salil S. Karipott (Eugene, Oregon) |
| ABSTRACT | Certain examples of the disclosure concern an apparatus including a microcarrier configured to receive and support attachment and growth of cells, and a magnetoelastic sensor enclosed by the microcarrier. The magnetoelastic sensor is configured to vibrate in response to an activation magnetic field, and the vibration can produce a return magnetic field having detectable field characteristics associated with the attachment or growth of the cells. |
| FILED | Thursday, December 31, 2020 |
| APPL NO | 17/789707 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 25/14 (20130101) C12M 35/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 11/14 (20130101) C12N 13/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/74 (20130101) G01N 33/48735 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230031708 | St-Pierre et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Baylor College of Medicine (Houston, Texas); William Marsh Rice University (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | François St-Pierre (Houston, Texas); Jihwan Lee (Houston, Texas); Zhuohe Liu (Houston, Texas); Peter Suzuki (Houston, Texas) |
| ABSTRACT | Provided herein are embodiments of methods and systems for screening cellular, subcellular, and multicellular structures. In one embodiment, a method for screening is provided comprising the steps of introducing a plurality of cellular, subcellular, or multicellular structures, or a combination thereof, to an imaging system, wherein one or more structures of the plurality comprise one or more taggable markers; imaging the plurality of structures using the imaging system; identifying one or more target structures among the plurality of structures based on one or more properties of the target structures; tagging the target structures to produce tagged target structures, wherein each target structure is selectively illuminated by an excitation light, thereby causing one or more taggable markers within the target structure to be phototransformed to produce one or more phototransformed taggable markers within the target structure; and isolating one or more tagged target structures from the plurality of structures. |
| FILED | Monday, January 25, 2021 |
| APPL NO | 17/759357 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/0227 (20130101) G01N 15/1456 (20130101) G01N 15/1468 (20130101) G01N 21/6458 (20130101) Original (OR) Class G01N 2015/149 (20130101) G01N 2015/0294 (20130101) G01N 2015/1493 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230032047 | Bar-Ziv et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MICHIGAN TECHNOLOGICAL UNIVERSITY (Houghton, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ezra Bar-Ziv (Atlantic Mine, Michigan); Stas Zinchik (Hancock, Michigan); Shreyas Sunil Kolapkar (Houghton, Michigan) |
| ABSTRACT | A system for torrefaction of waste material comprising biogenic material and plastic material may comprise a material pre-processing system, a heating and compaction unit, a reactor system comprising a reaction portion and an extrusion portion, and a cutting unit adjacent an outlet of the reactor system. A method for operating a system for torrefaction of waste material comprising biogenic and plastic material may comprise processing the waste material to generate waste material having an aspect ratio between 0.8:1 and 1.2:1 and a largest dimension of less than 4 millimeters (mm); compressing and heating the pre-processed waste material in the heating and compaction unit; heating the compacted waste material in the reactor system to a temperature of 280° C.-500° C.; extruding material from the reactor system; and cutting the extruded material into pellets. |
| FILED | Monday, March 14, 2022 |
| APPL NO | 17/693825 |
| CURRENT CPC | Fuels Not Otherwise Provided for; Natural Gas; Synthetic Natural Gas Obtained by Processes Not Covered by Subclasses C10G, C10K; Liquefied Petroleum Gas; Adding Materials to Fuels or Fires to Reduce Smoke or Undesirable Deposits or to Facilitate Soot Removal; Firelighters C10L 5/363 (20130101) C10L 5/406 (20130101) C10L 9/083 (20130101) Original (OR) Class C10L 2200/0461 (20130101) C10L 2200/0469 (20130101) C10L 2290/28 (20130101) C10L 2290/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230032136 | LANDER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Suhas RAO (Houston, Texas); Andreas GNIRKE (Cambridge, Massachusetts); Saul GODINEZ (Houston, Texas); Huiya GU (Houston, Texas); Elena STAMENOVA (Cambridge, Massachusetts); THE BROAD INSTITUTE, INC. (CAMBRIDGE, Massachusetts); BAYLOR COLLEGE OF MEDICINE (HOUSTON, Massachusetts); THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric S. LANDER (Cambridge, Massachusetts); Erez AIDEN (Houston, Texas); Huiya GU (Houston, Texas); Saul GODINEZ PULIDO (Houston, Texas); Suhas RAO (Stanford, California); Elena STAMENOVA (Cambridge, Massachusetts); Namita MITRA (Houston, Texas) |
| ABSTRACT | Disclosed are methods for detecting spatial proximity relationships between nucleic acid sequences, such as genomic DNA, in a cell. The method includes providing a sample of one or more crosslinked cells comprising nucleic acids; permeabilizing isolated nuclei under conditions that preserve contacts; fragmenting the nucleic acids present in the nuclei; filling in and repairing the ends with at least one labeled nucleotide; joining the filled in end of the fragmented nucleic acids that are in close physical proximity to create one or more end joined nucleic acid fragments having a junction; isolating the one or more end joined nucleic acid fragments using the labeled nucleotide; and determining the sequence at the junction of the one or more end joined nucleic acid fragments. |
| FILED | Friday, December 11, 2020 |
| APPL NO | 17/785042 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6841 (20130101) Original (OR) Class C12Q 2521/301 (20130101) C12Q 2521/501 (20130101) C12Q 2523/101 (20130101) C12Q 2535/122 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230032493 | Petropulu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | Athina Petropulu (New Brunswick, New Jersey); Zhaoyi Xu (New Brunswick, New Jersey) |
| ABSTRACT | Various embodiments comprise systems, methods, architectures, mechanisms and apparatus providing a dual-function radar communication (DFRC) system a multiple-input multiple-output (MIMO) radar is configured to have only a small number of its antennas active in each channel use. Probing waveforms are of an orthogonal frequency division multiplexing (OFDM) type. OFDM carriers are divided into two groups, one group that is used by the active antennas in a shared fashion, and another group where each subcarrier is assigned to an active antenna in an exclusive fashion (e.g., private subcarriers). Target estimation is carried out based on the received and transmitted symbols. The system communicates information via the transmitted OFDM data symbols and the pattern of active antennas in a generalized spatial modulation (GSM) fashion. A multi-antenna communication receiver can identify the indices of active antennas via sparse signal recovery methods. The private subcarriers may be used to synthesize a virtual array for high angular resolution, and also for improved estimation on the active antenna indices. |
| FILED | Thursday, July 07, 2022 |
| APPL NO | 17/860060 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/006 (20130101) Original (OR) Class G01S 13/584 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 27/36 (20130101) H04L 27/2627 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230033254 | Yeh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel H. Yeh (Tampa, Florida); Ivy Lea Cormier Drexler (St. Petersburg, Florida); Melanie Pickett (Tampa, Florida); David Fulcher (Tampa, Florida) |
| ABSTRACT | In one embodiment, an algae cultivation system includes a basin that contains a liquid and a photobioreactor at least partially immersed in the liquid of the basin, the photobioreactor comprising a closed container including multiple panels that together define an interior space in which algae can be cultivated, at least one of the panels being transparent, the photobioreactor further comprising an inflatable float associated with the container that can be filled with a gas to change one or both of the position and orientation of the container within the liquid. |
| FILED | Monday, October 03, 2022 |
| APPL NO | 17/959263 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/22 (20130101) C12M 23/50 (20130101) C12M 29/04 (20130101) C12M 29/20 (20130101) C12M 31/08 (20130101) C12M 41/32 (20130101) C12M 41/40 (20130101) C12M 41/46 (20130101) C12M 41/48 (20130101) C12M 47/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230033524 | Wu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Junqiao Wu (Kensington, California); Kechao Tang (Berkeley, California) |
| ABSTRACT | A material platform with controllable emissivity and fabrication methods are provided that permit the manipulation of thermal radiation detection and IR signal modulation and can be adapted to a variety of uses including infrared camouflage, thermal IR decoys, thermo-reflectance imaging and IR signal modulation. The platform is a multilayer WxV1-xO2 film with different W doping levels (x values) and layer thicknesses, forming a graded W-doped construct. In WVO2 films with a total thickness <100 nm, the graded doping of W spreads the originally sharp metal-insulator phase transition (MIT) to a broad temperature range, greatly expanding the temperature window for emissivity modulation. |
| FILED | Thursday, August 04, 2022 |
| APPL NO | 17/817475 |
| CURRENT CPC | Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials C03C 3/122 (20130101) Original (OR) Class C03C 4/082 (20130101) C03C 17/3417 (20130101) C03C 23/007 (20130101) C03C 2203/52 (20130101) C03C 2217/24 (20130101) C03C 2218/328 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230033526 | Wu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yuanpeng Wu (Ann Arbor, Michigan); Zetian Mi (Ann Arbor, Michigan) |
| ABSTRACT | A device includes a substrate, and a plurality of structures supported by the substrate, each structure of the plurality of structures including a Group III-nitride base, first and second Group III-nitride charge carrier injection layers supported by the Group III-nitride base, and a quantum heterostmcture disposed between the first and second charge carrier injection layers. The quantum hetero structure includes a pair of Group III-nitride barrier layers, and a Group III-nitride active layer disposed between the pair of Group III-nitride barrier layers. The Group III-nitride active layer has a thickness for quantum confinement of charge carriers. At least one of the pair of Group III-nitride barrier layers has a nitride surface adjacent to the Group III-nitride active layer. |
| FILED | Wednesday, December 23, 2020 |
| APPL NO | 17/788633 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 33/06 (20130101) Original (OR) Class H01L 33/007 (20130101) H01L 33/08 (20130101) H01L 33/24 (20130101) H01L 33/325 (20130101) H01L 2933/0016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230033629 | LUNT, III et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Trustees of Michigan State University (, None) |
| ASSIGNEE(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| INVENTOR(S) | Richard R. LUNT, III (Williamston, Michigan); Chenchen YANG (Holt, Michigan); Babak BORHAN (Okemos, Michigan); Mehdi MOEMENI (Okemos, Michigan); Matthew BATES (East Lansing, Michigan) |
| ABSTRACT | A transparent luminescent solar concentrator (TLSC) is provided. The TLSC includes a luminophore and a waveguide that guides light emitted from the luminophore. The TLSC has a light utilization efficiency (LUE) of greater than or equal to about 1. |
| FILED | Monday, July 18, 2022 |
| APPL NO | 17/867022 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/048 (20130101) H01L 31/055 (20130101) Original (OR) Class H01L 31/0543 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230034179 | NADERI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yousof NADERI (Brookline, Massachusetts); Kaushik CHOWDHURY (Needham, Massachusetts) |
| ABSTRACT | The presently disclosed embodiments generally relate to systems, devices, and methods for sensing and charging of electronic devices using coils. In some embodiments, the presently disclosed system can include a pad, a charging foot, and a backpack. The pad can include one or more nested coils therein that can sense one or more corresponding receiver coils of an unmanned aerial vehicles (UAV) that landed thereon. The nested coils of the pad can provide charging energy to the UAV independent of the location along the pad in which the UAV landed, and no precise alignment between the receiver coils and the charging coils is required. The charging foot can be attached to one or more legs of the UAV, and can include a receiver coil and circuitry to regulate energy received by the coil to a charging voltage level that can be provided to the battery. |
| FILED | Wednesday, September 28, 2022 |
| APPL NO | 17/954584 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 39/024 (20130101) Original (OR) Class B64C 2201/042 (20130101) B64C 2201/141 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 50/12 (20160201) H02J 50/90 (20160201) H02J 50/402 (20200101) H02J 2310/44 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230034642 | Chang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Oregon State University (Corvallis, Oregon) |
| ASSIGNEE(S) | Oregon State University (Corvallis, Oregon) |
| INVENTOR(S) | Chih-hung Chang (Corvallis, Oregon); Venkata Vinay Krishna Doddapaneni (Corvallis, Oregon); Yujuan He (Corvallis, Oregon); Jeffrey Dhas (Corvallis, Oregon); Brian K. Paul (Corvallis, Oregon); Somayeh Pasebani (Corvallis, Oregon); Chuankai Song (Corvallis, Oregon); Sakineh Abbasi (Corvallis, Oregon) |
| ABSTRACT | A print head comprising nested chambers for in-situ reactant formation is disclosed. The print head comprises a first chamber nested within a second chamber. The first chamber comprises a first nozzle, the second chamber comprises a second nozzle. The first nozzle is substantially coaxial with the second nozzle. A susceptor to convert electromagnetic energy to heat is within the first chamber. The susceptor comprises one or more openings extending between the upper portion and the lower portion. The susceptor may be heated by induction heating or by optical heating to vaporize a precursor substance within the first chamber. The vapor may react with a reactive gas flowing through the first chamber or expand through a nozzle into a second chamber where the vapor may react with the reactive gas, forming nanoparticles. Patterned films may be written onto a two-dimensional or three-dimensional surfaces. |
| FILED | Tuesday, July 26, 2022 |
| APPL NO | 17/814914 |
| CURRENT CPC | Spraying Apparatus; Atomising Apparatus; Nozzles B05B 1/28 (20130101) B05B 7/0075 (20130101) Processes for Applying Fluent Materials to Surfaces, in General B05D 1/12 (20130101) Original (OR) Class Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/118 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230034660 | Aizenman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Elias Aizenman (Pittsburgh, Pennsylvania); Athanassios Tzounopoulos (Pittsburgh, Pennsylvania) |
| ABSTRACT | Peptides capable of enhancing N-methyl D-aspartate (NMDA) receptor activity by inhibiting binding of the NMDA receptor GluN2A to zinc transporter 1 (Zn1) are described. The GluN2A-derived peptides can be used to in the treatment of disorders associated with NMDA receptor hypofunction, such as schizophrenia. |
| FILED | Thursday, December 03, 2020 |
| APPL NO | 17/782388 |
| CURRENT CPC | Peptides C07K 7/06 (20130101) Original (OR) Class C07K 7/08 (20130101) C07K 2319/10 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230035127 | He et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaoming He (Bethesda, Maryland); Bin Jiang (College Park, Maryland) |
| ABSTRACT | Methods and compositions for the production of cardiomyocytes and cardiac organoids from the differentiation of pluripotent stem cells in three-dimensional (3D) culture are provided. Rock inhibitor, which has been ubiquitously used as a medium supplement to prevent apoptosis during handling and culture of pluripotent stem cells, compromises the capacity of cardiac differentiation of pluripotent stem cells in 3D culture at the most commonly used concentrations. |
| FILED | Thursday, July 21, 2022 |
| APPL NO | 17/814044 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0657 (20130101) C12N 2500/12 (20130101) C12N 2500/32 (20130101) C12N 2500/44 (20130101) C12N 2501/15 (20130101) C12N 2501/115 (20130101) C12N 2501/415 (20130101) C12N 2501/727 (20130101) C12N 2503/02 (20130101) C12N 2506/45 (20130101) C12N 2513/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5061 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230037160 | Manuel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michele Viola Manuel (Gainesville, Florida); Ida E. Svensson Berglund (Chicago, Illinois); Benjamin G. Keselowsky (Gainesville, Florida); Malisa Sarntinoranont (Gainesville, Florida); Harpreet Singh Brar (Hillsboro, Oregon); Hunter B. Henderson (Gainesville, Florida) |
| ABSTRACT | Embodiments of the present disclosure provide for structures including an alloy of calcium, strontium, and magnesium. |
| FILED | Tuesday, September 27, 2022 |
| APPL NO | 17/953407 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 33/06 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/047 (20130101) Original (OR) Class A61L 27/54 (20130101) A61L 27/58 (20130101) A61L 31/16 (20130101) A61L 31/022 (20130101) A61L 31/148 (20130101) A61L 2300/43 (20130101) A61L 2300/258 (20130101) A61L 2300/414 (20130101) A61L 2430/02 (20130101) A61L 2430/12 (20130101) A61L 2430/38 (20130101) Alloys C22C 23/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230037237 | SEGAL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | COLORADO SCHOOL OF MINES (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Avigal Denise SEGAL (Evergreen, Colorado); Andrew Jacob PETRUSKA (Golden, Colorado); Anne Katherine SILVERMAN (Golden, Colorado) |
| ABSTRACT | In one embodiment, a method of providing an intervention, includes: obtaining a motion sensing device configured for manipulation by a user; creating, via one or more processing elements, a communication link between the motion sensing device and a robot; and detecting, via the motion sensing device, a movement initiated by the user; creating, via the one or more processing elements, a signal within the sensing device; transmitting, via the one or more processing elements, the signal to the robot; and moving the robot based on the signal. |
| FILED | Tuesday, July 19, 2022 |
| APPL NO | 17/868466 |
| CURRENT CPC | Systems for Controlling or Regulating Non-electric Variables G05D 1/0016 (20130101) Original (OR) Class G05D 1/0033 (20130101) G05D 2201/0214 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20230031927 | Boehme et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PowerTech Water, Inc. (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lindsay Boehme (Iowa City, Iowa); Cameron Lippert (Lexington, Kentucky); James Richardson Landon (Lexington, Kentucky); Alan Rassoolkhani (Lexington, Kentucky); Jeffrey Rentschler (Lexington, Kentucky) |
| ABSTRACT | The present invention is directed to an electrochemical device for at least partially removing or reducing a target ionic species from an aqueous solution using faradic immobilization, the electrochemical device including at least one first electrode and at least one second electrode with different void fraction and surface area properties, due to differences in void fraction (also referred to as void ratio) of the at least one first and the at least one second electrode, water flows through an electrode with a high porosity, while the aqueous solution does not flow through an electrode with a low porosity. The asymmetry of the electrodes provides a desired voltage distribution across the device, which equates to a different voltage at each electrode, to control the speciation of the target ionic species at the anode and the cathode. |
| FILED | Thursday, September 15, 2022 |
| APPL NO | 17/932488 |
| CURRENT CPC | Separation B01D 61/485 (20130101) Original (OR) Class B01D 71/021 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/46109 (20130101) C02F 2101/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230032369 | OAKES et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Scribe Therapeutics, Inc. (Alameda, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin OAKES (El Cerrito, California); Sean HIGGINS (Alameda, California); Hannah SPINNER (Boston, Massachusetts); Sarah DENNY (San Francisco, California); Brett T. STAAHL (Tiburon, California); Kian TAYLOR (Atlanta, Georgia); Katherine BANEY (Berkeley, California); Isabel COLIN (Oakland, California); Maroof ADIL (Davis, California); Cole URNES (Los Angeles, California) |
| ABSTRACT | Provided herein are CRISPR:guide systems comprising Class 2 Type V polypeptides (e.g. CasX:gNA systems comprising CasX polypeptides), guide nucleic acids (gNA), and optionally donor template nucleic acids useful in the modification of a HTT gene. The systems are also useful for introduction into cells, for example eukaryotic cells having mutations in the huntingtin protein. Also provided are methods of using such systems to modify cells having such mutations and utility in methods of treatment of a subject with a HTT-related disease, such as Huntington's disease. |
| FILED | Tuesday, May 31, 2022 |
| APPL NO | 17/829206 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/86 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230032932 | Butterworth et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Leuko Labs, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ian Butterworth (Somerville, Massachusetts); Carlos Castro-Gonzalez (Cambridge, Massachusetts); Aurelien Bourquard (Madrid, Spain); Alvaro Sanchez Ferro (Madrid, Spain); Ganimete Lamaj (Cambridge, Massachusetts); Nolan Bell (Somerville, Massachusetts); Ryan Benasutti (Milford, New Hampshire); Alberto Pablo-Trinidad (Madrid, Spain) |
| ABSTRACT | An automated system for acquiring images of one or more capillaries in a capillary bed includes a platform for receiving a body portion of a subject, an imaging subsystem having a repositionable field of view and coupled to the platform to acquire images of at least a capillary bed of the body portion and a controller communicably coupled to the imaging subsystem to automatically reposition the field of view of the imaging subsystem to different areas of the capillary bed, and at each field of view within the capillary bed, activate the imaging subsystem to acquire images of one or more capillaries in the capillary bed. |
| FILED | Monday, August 01, 2022 |
| APPL NO | 17/878128 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 19/0085 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 7/10732 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230034610 | Piasecki et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Dragonfly Pictures, Inc. (Essington, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael W. Piasecki (Haverford, Pennsylvania); Joseph S. Pawelczyk, JR. (Philadelphia, Pennsylvania); Jeffrey Field (Springfield, Pennsylvania) |
| ABSTRACT | An unmanned aerial signal relay includes an unmanned aerial vehicle, including a communication relay unit and at least one antenna, communicatively connected to the communication relay unit; a tether comprising at least two wires and at least one fiber optic cable, the wires and cable communicatively connected to the unmanned aerial vehicle; and a surface support system comprising a spool physically connected to the tether and a ground-based receiver communicatively connected to the at least one fiber optic cable, wherein the unmanned aerial vehicle is powered by electrical energy provided by the at least two wires, and wherein the communication relay unit is configured to relay signals received from the at least one antenna via the fiber optic cable to the ground-based receiver. Various systems and methods related to an unmanned aerial signal relay are also described. |
| FILED | Friday, October 07, 2022 |
| APPL NO | 17/938751 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 39/022 (20130101) Original (OR) Class B64C 39/024 (20130101) B64C 2201/122 (20130101) B64C 2201/205 (20130101) Transmission H04B 10/2575 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230034750 | Piasecki et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Dragonfly Pictures, Inc. (Essington, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael W. Piasecki (Haverford, Pennsylvania); Joseph S. Pawelczyk, Jr. (Philadelphia, Pennsylvania); Jeffrey Field (Springfield, Pennsylvania) |
| ABSTRACT | An unmanned aerial signal relay includes an unmanned aerial vehicle, including a communication relay unit and at least one antenna, communicatively connected to the communication relay unit; a tether comprising at least two wires and at least one fiber optic cable, the wires and cable communicatively connected to the unmanned aerial vehicle; and a surface support system comprising a spool physically connected to the tether and a ground-based receiver communicatively connected to the at least one fiber optic cable, wherein the unmanned aerial vehicle is powered by electrical energy provided by the at least two wires, and wherein the communication relay unit is configured to relay signals received from the at least one antenna via the fiber optic cable to the ground-based receiver. Various systems and methods related to an unmanned aerial signal relay are also described. |
| FILED | Friday, October 07, 2022 |
| APPL NO | 17/938754 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 39/022 (20130101) Original (OR) Class B64C 39/024 (20130101) B64C 2201/122 (20130101) B64C 2201/205 (20130101) Transmission H04B 10/2575 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230035727 | HUNG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | COMBINATI INCORPORATED (Carlsbad, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ju-Sung HUNG (Palo Alto, California); Felicia LINN (Patterson, California); Robert LIN (Palo Alto, California) |
| ABSTRACT | The present disclose provides methods for forming a microfluidic device. Methods for forming a microfluidic device may comprise providing a microfluidic structure and a film, treating a surface of the microfluidic structure, a surface of the film, or both with a solvent, subsequently pressing the microfluidic structure together with the film under a first heating condition to form the microfluidic device comprising the solvent, and applying a negative pressure to the microfluidic device under a second heating condition, which negative pressure is applied for a time period greater than 30 minutes or at a pressure less than 20 kilopascals (kPa) to remove at least a portion of the solvent. In some aspects, the present disclosure provides devices consistent with the methods herein. |
| FILED | Friday, January 22, 2021 |
| APPL NO | 17/759070 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502707 (20130101) Original (OR) Class B01L 2300/0864 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 71/02 (20130101) B29C 71/0009 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20230029556 | Zhu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jiaqi Dai (Washington, District of Columbia); Yelizaveta Pikus (Phoenix, Arizona); The United States, as represented by the Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Junyong Zhu (Madison, Wisconsin); Roland Gleisner (Jefferson, Wisconsin); Riley Simson (Madison, Wisconsin); Jiaqi Dai (Washington, District of Columbia); Yelizaveta Pikus (Phoenix, Arizona) |
| ABSTRACT | Methods for producing structural materials from lumber are provided. The methods use an oxygen pre-treatment or a carbonate pre-treatment followed by densification via thermal compression to produce structural materials with strong mechanical properties. The pre-treatments are able to partially delignify the lumber without substantially adversely affecting the mechanical properties of the subsequently densified wood. |
| FILED | Thursday, July 14, 2022 |
| APPL NO | 17/864763 |
| CURRENT CPC | Processes, Apparatus or Selection of Substances for Impregnating, Staining, Dyeing, Bleaching of Wood or Similar Materials, or Treating of Wood or Similar Materials With Permeant Liquids, Not Otherwise Provided for; Chemical or Physical Treatment of Cork, Cane, Reed, Straw or Similar Materials B27K 3/08 (20130101) B27K 3/18 (20130101) B27K 3/32 (20130101) B27K 5/065 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230030639 | REARDON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | CATHERINE L. REARDON (WALLA WALLA, Washington); KRISTIN M. TRIPPE (PHILOMATH, Oregon); VIOLA MANNING (PHILOMATH, Oregon) |
| ABSTRACT | Disclosed are isothiocyanate (ITC)-detecting biosensors that utilize recombinant host cells containing an ITC responsive genetic element such as a saxA promoter, operably linked with a reporter element, such as a luxCDABE operon or ilux operon. Such biosensors can detect the presence of diverse ITCs in samples such as plant extracts, biofumigated soils and seed meal amended soils. |
| FILED | Wednesday, July 28, 2021 |
| APPL NO | 17/386917 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/39 (20210501) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/28 (20130101) G01N 21/763 (20130101) Original (OR) Class G01N 33/24 (20130101) G01N 33/5097 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230032478 | DUBCOVSKY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); CONSEJO NACIONAL DE INVESTIGACIONES CIENTÍFICAS Y TÉCNICAS (Ciudad Autonoma de Buenos Aires, Argentina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | JORGE DUBCOVSKY (Oakland, California); JUAN MANUEL DEBERNARDI (Oakland, California); DAVID TRICOLI (Oakland, California); JAVIER PALATNIK (Ciudad Autonoma de Buenos Aires, Argentina) |
| ABSTRACT | Disclosed are methods of producing plants with an improved regeneration efficiency using Growth-Regulating Factor (GRF), GRF-Interacting Factor (GIF), or chimeric GRF-GIF genes and proteins. The disclosure also provides plants with an improved regeneration efficiency that are produced by the disclosed methods, methods of reducing the use of exogenous cytokinins in the regeneration of plants, and methods of improving the regeneration efficiency of plants. |
| FILED | Wednesday, July 08, 2020 |
| APPL NO | 17/597511 |
| CURRENT CPC | Peptides C07K 14/475 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8262 (20130101) Original (OR) Class C12N 15/8295 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20230035004 — THERAPEUTIC COMPOSITIONS CONTAINING BACTERIAL OUTER MEMBRANE VESICLES AND USES THEREOF
| US 20230035004 | Heck et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NUtech Ventures (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kari Heck (Lincoln, Nebraska); Amanda Ellen Ramer-Tait (Lincoln, Nebraska); Angela Kaye Pannier (Lincoln, Nebraska) |
| ABSTRACT | This document provides therapeutic compositions, methods of making, and methods of using the described therapeutic compositions that include outer membrane vesicles. |
| FILED | Thursday, July 28, 2022 |
| APPL NO | 17/815729 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5068 (20130101) Original (OR) Class A61K 9/5161 (20130101) A61K 31/713 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20230032022 | Klimov et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nikolai Nikolaevich Klimov (Ellicott City, Maryland); Nathan Andrew Tomlin (Boulder, Colorado); Christopher Shing-Yu Yung (Louisville, Colorado) |
| ABSTRACT | A photonic bolometer includes: a photonic chip; a weak thermal link; a thermally-isolated member, and the weak thermal link thermally isolates the thermally-isolated member from the photonic chip; a photonic temperature sensor; a chip waveguide in optical communication with the photonic temperature sensor; and a photon absorber that receives incident radiation light, increases temperature due to absorption of the incident radiation light, heats the photonic temperature sensor in response to receipt of the incident radiation light, and changes the resonance frequency of the photonic temperature sensor in response to receiving the incident radiation light. |
| FILED | Friday, September 30, 2022 |
| APPL NO | 17/957817 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 5/20 (20130101) G01J 5/58 (20130101) Original (OR) Class G01J 5/0818 (20130101) G01J 5/0853 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20230032558 | Boyd et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Daniel A. Boyd (Arlington, Virginia); Kelli L. Biegger (Alexandria, Virginia); Chang Ellison (Arlington, Virginia); Brandon P. Gutierrez (Johns Creek, Georgia); Jason Lim (Alexandria, Virginia); William Washington (North Potomac, Maryland) |
| ABSTRACT | An apparatus verifies hosted information associated with a user. The apparatus establishes, by the online host serving as a relying party system (RPS), a secure connection between the RPS and a user mobile-identification-credential device (UMD). The RPS sends a mobile identification credential (MIC) user information request to the UMD, via the secure connection, seeking release of MIC user information (official information). The RPS obtains from authorizing party system (APS) verification of the MIC user information received in response to the MIC user information request. The RPS stores the MIC user information as hosted information pertaining to the user. The RPS designates the hosted information as base truth information representing the user. |
| FILED | Thursday, September 29, 2022 |
| APPL NO | 17/955801 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/32 (20130101) Original (OR) Class G06F 2221/2133 (20130101) Image or Video Recognition or Understanding G06V 10/40 (20220101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0825 (20130101) H04L 9/3213 (20130101) H04L 9/3247 (20130101) H04L 63/0823 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Non-Profit Organization (NPO)
| US 20230031750 | Li et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | University of Southern California (Los Angeles, California) |
| INVENTOR(S) | Tianye Li (Los Angeles, California); Yajie Zhao (Los Angeles, California); Shichen Liu (Los Angeles, California); Jiayi Liu (Los Angeles, California); Hao Li (Los Angeles, California) |
| ABSTRACT | Systems and methods are provided for generating topologically consistent meshes across various subjects, objects, and/or various facial expressions using a volumetric representation. In one example, a progressive mesh generation network is configured to embed the topological structure of a subject or an object in a feature volume sampled from a geometry-aware local features. Further, a coarse-to-fine iterative architecture facilitates dense and accurate facial mesh predictions using a consistent mesh topology. In another example, one or more high-quality asset maps may be generated from a final base mesh. |
| FILED | Tuesday, May 03, 2022 |
| APPL NO | 17/735568 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 3/40 (20130101) G06T 17/20 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Office of the Director of National Intelligence (ODNI)
| US 20230030373 | Vaughan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alexander G. VAUGHAN (Cold Spring Harbor, New York); Anthony M. ZADOR (Cold Spring Harbor, New York) |
| ASSIGNEE(S) | Cold Spring Harbor Laboratory (Cold Spring Harbor, New York) |
| INVENTOR(S) | Alexander G. Vaughan (Cold Spring Harbor, New York); Anthony M. Zador (Cold Spring Harbor, New York) |
| ABSTRACT | Recently, advances in next-generation sequencing have arisen from the spatial isolation of each molecule into a small volume, enabling many single-molecule sequencing reactions to run in parallel. The fundamental limit to throughput with this technique is the need to isolate individual molecules on a spatial scale, so that sequencing signals are not mixed. Here we disrupt this limit, by observing that, in many cases, it is possible to accurately sequence complex mixtures of DNA and RNA species by exploiting the toolkit of modern compressed sensing and incorporating additional relational information about the relationship between many sequencing problems. This approach thus provides a dramatic increase in the density of DNA molecules in the sequencing reaction for both in-vitro and in-situ techniques. |
| FILED | Wednesday, December 23, 2020 |
| APPL NO | 17/788603 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 30/00 (20190201) G16B 40/10 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20230035302 | Packer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Travis J. Packer (Lebanon, Ohio); James Hamilton Grooms (Hamilton, Ohio); David Fasig (Stevensville, Maryland); Richard William Jendrix (Liberty Township, Ohio); Scott Alan Schimmels (Miamisburg, Ohio); Bradford Alan Tracey (Cold Spring, Kentucky); Michael Alan Hile (Cincinnati, Ohio); Thomas Ryan Wallace (Cincinnati, Ohio) |
| ABSTRACT | A clearance control assembly for a gas turbine engine that defines an axial direction and a radial direction and includes a stage of rotor blades and a shroud hanger. The assembly includes a case configured to be positioned outward along the radial direction from the stage of rotor blades when installed in the gas turbine engine. The case is further configured to be engaged with the shroud hanger at a first location when installed in the gas turbine engine. The assembly also includes a baffle positioned outward along the radial direction from the case to define a chamber therebetween. The baffle has a forward end and an aft end. The forward end of the baffle is engaged with the case to form a first seal and the aft end of the baffle is engaged with the case to form a second seal. The baffle, the case, or both define an inlet to allow a fluid to enter the chamber and the case defines an outlet to allow the fluid to exit the chamber. |
| FILED | Thursday, July 29, 2021 |
| APPL NO | 17/388228 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 9/02 (20130101) F01D 11/24 (20130101) Original (OR) Class F01D 25/243 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2240/55 (20130101) F05D 2240/126 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230036437 | Swernofsky et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | Raytheon Company (, None) |
| INVENTOR(S) | David E. Swernofsky (Richardson, Texas); Robert Larson (Dallas, Texas) |
| ABSTRACT | A fluid system and a blind-mate fluid fitting is provided. The blind-mate fluid fitting includes a shoulder and fitting portion extending from one side of the shoulder. The fitting portion defines a central fitting axis and is operable to inserted into a fluid port of a component. The fluid port defines a central port axis. The fitting portion includes a sealing portion that is operable to seal against the fluid port when the central fitting axis is positioned at a zero angle and at least one of a plurality of different non-zero angles relative to the central port axis. |
| FILED | Friday, July 30, 2021 |
| APPL NO | 17/390863 |
| CURRENT CPC | Pipes; Joints or Fittings for Pipes; Supports for Pipes, Cables or Protective Tubing; Means for Thermal Insulation in General F16L 17/00 (20130101) F16L 37/52 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, February 02, 2023.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
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HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20230202.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
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