FedInvent™ Patent Applications
Application Details for Thursday, February 09, 2023
This page was updated on Friday, February 10, 2023 at 10:24 PM GMT
Department of Health and Human Services (HHS)
| US 20230037294 | Bradbury et al. |
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| FUNDED BY |
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| APPLICANT(S) | Memorial Sloan Kettering Cancer Center (New York, New York); Cornell University (Ithaca, New York); The Curators of the University of Missouri (Columbia, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michelle S. Bradbury (New York, New York); Thomas P. Quinn (Columbia, Missouri); Feng Chen (New York, New York); Barney Yoo (New York, New York); Jason Lewis (New York, New York); Ulrich Wiesner (Ithaca, New York); Kai Ma (Ithaca, New York) |
| ABSTRACT | Disclosed herein are nanoparticle immunoconjugates useful for therapeutics and/or diagnostics. The immunoconjugates have diameter (e.g., average diameter) no greater than 20 nanometers (e.g., as measured by dynamic light scattering (DLS) in aqueous solution, e.g., saline solution). In certain embodiments, the conjugates are silica-based nanoparticles with single chain antibody fragments attached thereto. |
| FILED | Friday, October 07, 2022 |
| APPL NO | 17/961761 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) A61K 47/6923 (20170801) Original (OR) Class A61K 49/0058 (20130101) A61K 49/1824 (20130101) A61K 51/10 (20130101) A61K 51/0478 (20130101) A61K 51/1093 (20130101) A61K 51/1251 (20130101) Peptides C07K 16/40 (20130101) C07K 2317/55 (20130101) C07K 2317/569 (20130101) C07K 2317/622 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230037361 | Yelick et al. |
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| FUNDED BY |
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| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts); The Brigham and Women's Hospital, Inc. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pamela C. Yelick (Boston, Massachusetts); Ali Khademhosseini (Cambridge, Massachusetts) |
| ABSTRACT | A dental tissue regenerative composition. The composition includes a combination of (1) human dental pulp stem cells and (2) at least one of human umbilical vein endothelial cells or vascular endothelial growth factor. The combination is encapsulated in a light-activated gelatin methacrylate hydrogel. |
| FILED | Thursday, October 20, 2022 |
| APPL NO | 17/969990 |
| CURRENT CPC | Dentistry; Apparatus or Methods for Oral or Dental Hygiene A61C 5/40 (20170201) Preparations for Medical, Dental, or Toilet Purposes A61K 6/56 (20200101) A61K 6/62 (20200101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230037654 | Singapogu et al. |
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| FUNDED BY |
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| APPLICANT(S) | Clemson University Research Foundation (Clemson, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ravikiran Singapogu (Pendleton, South Carolina); Zhanhe Liu (Clemson, South Carolina); Ziyang Zhang (Clemson, South Carolina); Lydia Petersen (Clemson, South Carolina); David Moline (Pendleton, South Carolina); Devansh Shukla (Clemson, South Carolina) |
| ABSTRACT | Disclosed herein is a system for evaluating a user during a physical cannulation simulation. The system includes a physical cannulation simulator and one or more sensors configured to measure data during the physical cannulation simulation by the user using the physical cannulation simulator. The system further includes one or more processors configured to receive the data measured by each of the one or more sensors and calculate metrics using the data. The one or more processors are further configured to apply a model to the metrics to determine a composite simulation success score and compare the composite simulation success score to a threshold score. In response to comparing the composite simulation success score to the threshold score, the one or more processors are configured to output an indication of one or more of an absolute performance or a relative performance for the first user during the physical cannulation simulation. |
| FILED | Thursday, July 14, 2022 |
| APPL NO | 17/864545 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/014 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 23/285 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230037794 | Zhang et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| INVENTOR(S) | Feng Zhang (Cambridge, Massachusetts); Han Altae-Tran (Cambridge, Massachusetts) |
| ABSTRACT | Described in certain exemplary embodiments herein are programmable DNA nuclease systems and/or components thereof that include or are otherwise associated with a ligase. Also described in certain exemplary embodiments herein are method of using the DNA nuclease systems described herein to modify a nucleic acid sequence. |
| FILED | Wednesday, December 23, 2020 |
| APPL NO | 17/785070 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 9/93 (20130101) C12N 15/86 (20130101) C12N 15/8216 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230037822 | Paulson et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Scripps Research Institute (La Jolla, California) |
| ASSIGNEE(S) | The Scripps Research Institute (La Jolla, California) |
| INVENTOR(S) | James C. Paulson (Del Mar, California); Maidul Islam (San Diego, California); Fabian Pfrengle (Klosterneuburg, Austria); Matthew Macauley (Edmonton, Canada); Shiteng Duan (San Diego, California); Britni Arlian (Spring Valley, California) |
| ABSTRACT | Described herein are Siglec ligand-antibody conjugates and compositions thereof that are useful for suppressing unwanted immune responses such as allergies and anaphylaxis. |
| FILED | Wednesday, October 28, 2020 |
| APPL NO | 17/755382 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6807 (20170801) A61K 47/6849 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/08 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230037926 | SINHA et al. |
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| FUNDED BY |
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| APPLICANT(S) | CHILDREN'S NATIONAL MEDICAL CENTER (Washington, District of Columbia) |
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| INVENTOR(S) | Pranava SINHA (Arlington, Virginia); William A. SMITH (Lyndhurst, Ohio); Stephan WEBER (Lyndhurst, Ohio) |
| ABSTRACT | The circulation assist devices disclosed herein can be used, for example, in methods of decreasing venous pressure in the Fontan circulation. The devices can include an inlet, an outlet, a stator, a rotor, and an impeller driven by rotation of the rotor. In some embodiments, the impeller blade (or blades) can at least partially define a central lumen extending through the device. The device can be coupled to the inferior vena cava and the pulmonary artery. Rotating the impeller blade(s) increases blood velocity through the lumen and causes the outlet pressure to be higher than the inlet pressure. The impeller can be configured such that, when it is stationary, the forward static pressure drop between the inlet and the outlet is minimized. That is, the forward static pressure drop of the device approximates the pressure drop between the inferior vena cava and central pulmonary artery of the unassisted Fontan circulation. |
| FILED | Monday, December 28, 2020 |
| APPL NO | 17/790023 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 60/35 (20210101) A61M 60/148 (20210101) Original (OR) Class A61M 60/237 (20210101) A61M 60/422 (20210101) A61M 60/806 (20210101) A61M 60/824 (20210101) A61M 60/827 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230037966 | Guo et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
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| INVENTOR(S) | Wei Guo (Wynnewood, Pennsylvania); Bin Wu (Wynnewood, Pennsylvania) |
| ABSTRACT | The present disclosure provides methods for predicting and thereby treating cancer or increasing the efficacy of an anti-cancer medication, in part by measuring checkpoint proteins on extracellular vesicles released from non-cancer cells. These checkpoint proteins promote cancer progression and/or compensate for the loss of signal from the checkpoint proteins being inhibited by the checkpoint inhibitory therapy. Compositions and methods of treatment are also provided. |
| FILED | Thursday, January 07, 2021 |
| APPL NO | 17/790622 |
| CURRENT CPC | Peptides C07K 16/30 (20130101) Original (OR) Class C07K 16/42 (20130101) C07K 16/2812 (20130101) C07K 2317/24 (20130101) C07K 2317/76 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5076 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230038081 | Bailey et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Michael R. Bailey (Seattle, Washington); Mohamed Abdalla Ghanem (Seattle, Washington); Adam D. Maxwell (Seattle, Washington) |
| ABSTRACT | Non-planar holographic beam shaping lenses for acoustics are disclosed herein. In one embodiment, an ultrasonic therapy system that is configured to apply ultrasound to a target in a body includes: an ultrasonic transducer configured to generate the ultrasound; and a customizable holographic lens configured to focus the ultrasound onto a focal area of a target that is an object or a portion of the object in the body. The customizable holographic lens is designed and produced based on the target. Furthermore, the customizable holographic lens is curved to mate with a front surface of the ultrasonic transducer. |
| FILED | Thursday, August 04, 2022 |
| APPL NO | 17/881026 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 7/00 (20130101) Original (OR) Class A61N 2007/006 (20130101) Producing Particular Articles From Plastics or From Substances in a Plastic State B29D 11/00009 (20130101) Optical Elements, Systems, or Apparatus G02B 5/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230038166 | NICK et al. |
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| FUNDED BY |
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| APPLICANT(S) | NATIONAL JEWISH HEALTH (Denver, Colorado); COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (Fort Collins, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jerry Allan NICK (Denver, Colorado); Delphi CHATTERJEE (Fort Collins, Colorado) |
| ABSTRACT | Methods for detecting a mycobacterial infection in a patient are disclosed. These methods include the step of detecting lipoarabinomannan (LAM) and/or derivatives thereof in a biological sample from the patient. Methods for diagnosing disease, including nontuberculous mycobacterial infection (NTM), and kits for the described methods are also provided. |
| FILED | Thursday, December 17, 2020 |
| APPL NO | 17/778355 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/92 (20130101) G01N 33/5695 (20130101) Original (OR) Class G01N 2800/122 (20130101) G01N 2800/382 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230038168 | Kamp et al. |
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| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Timothy Joseph Kamp (Madison, Wisconsin); Pratik Arvind Lalit (Madison, Wisconsin) |
| ABSTRACT | Animal cells, notably adult fibroblasts, are advantageously reprogrammed in direct lineage reprogramming methods using defined factors to produce proliferative and multipotent induced cardiac progenitor cells (iCPC). The iCPC thus produced can be differentiated under suitable differentiation conditions to cardiac lineage cells including cardiomyocytes, smooth muscle cells, and endothelial cells, as evidenced by expression of lineage specific markers. Sets of factors effective in combination to reprogram the fibroblasts can include a set that includes some or all of 5 factors (Mesp1, Baf60c, Nkx2.5, Gata4, Tbx5), a set that includes some or all of 11 factors (Mesp1, Mesp2, Gata4, Gata6, Baf60c, SRF, Isl1, Nkx2.5, Irx4, Tbx5, Tbx20), a set that includes some or all of 18 factors (T, Mesp1, Mesp2, Tbx5, Tbx20, Isl1, Gata4, Gata6, Irx4, Nkx2.5, Hand1, Hand2, Tbx20, Tbx18, Tip60, Baf60c, SRF, Hey2), and a set that includes some or all of 22 factors (T, Mesp1, Mesp2, Tbx5, Tbx20, Isl1, Gata4, Gata6, Irx4, Nkx2.5, Hand1, Hand2, Tbx20, Tbx18, Tip60, Baf60c, SRF, Hey2, Oct4, Klf4, Sox2, L-myc). |
| FILED | Thursday, June 30, 2022 |
| APPL NO | 17/855379 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0657 (20130101) Original (OR) Class C12N 5/0661 (20130101) C12N 2501/06 (20130101) C12N 2501/60 (20130101) C12N 2501/415 (20130101) C12N 2506/1307 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230038185 | Gillies et al. |
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| FUNDED BY |
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| APPLICANT(S) | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE INC. (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert J. Gillies (Tampa, Florida); Matthew B. Schabath (Tampa, Florida); Wei MU (Tampa, Florida) |
| ABSTRACT | Two major treatment strategies employed in fighting non-small cell lung cancer (NSCLC) are tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs). The choice of strategy is based on heterogeneous biomarkers expressed by the lung tumor tissue. A major challenge for molecular testing of these biomarkers is the insufficiency of biopsy specimens from patients with advanced NSCLC. Disclosed herein is a method for predicting a response to immune-checkpoint blockade immunotherapy. The method generally involves imaging the subject with positron emission tomography with 2-deoxy-2-[fluorine-18] fluoro-D-glucose integrated with computed tomography to produce 18F-FDG PET/CT images of the tumor, analyzing the images using PET, CT, and Kulbek Leibler Divergence statistical (KLD) features or, alternatively using deep leaning such as Neural Networks; generating a radiomic signature from the identified features or Network characteristics; and computing a radiomic score based on the radiomic signature that is predictive of responsiveness to ICIs or TKIs. |
| FILED | Monday, December 07, 2020 |
| APPL NO | 17/757017 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/5235 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 51/0491 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Computer Systems Based on Specific Computational Models G06N 3/082 (20130101) G06N 3/0454 (20130101) Image or Video Recognition or Understanding G06V 10/454 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230038202 | TEREK et al. |
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| FUNDED BY |
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| APPLICANT(S) | Rhode Island Hospital (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard TEREK (Providence, Rhode Island); Qian CHEN (Barrington, Rhode Island); Xiaojuan SUN (Barrington, Rhode Island) |
| ABSTRACT | This invention is directed to, inter alia, compositions and methods for restoring normal microRNA (miR) expression in chondrosarcoma cells as well as methods for treating and diagnosing chondrosarcoma in individuals in need thereof. |
| FILED | Friday, June 17, 2022 |
| APPL NO | 17/843848 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/5184 (20130101) A61K 31/395 (20130101) A61K 31/7105 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230038480 | STEPHENS et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland); THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (Washington, District of Columbia) |
| ASSIGNEE(S) | UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland); THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (Washington, District of Columbia) |
| INVENTOR(S) | Kristina STEPHENS (Takoma Park, Maryland); William E. BENTLEY (Annapolis, Maryland); Jessica Lynn LIBA (Drexel Hill, Pennsylvania); Ryan MCKAY (Peekskill, New York); Micaela EVERITT (Washington, District of Columbia) |
| ABSTRACT | The presently disclosure relates to a system and method for bioelectronic communications. In certain embodiments the system comprises a bacterial cell or cells that comprise a genetic system for high-efficiency over-expression and secretion of recombinant proteins in bacteria. In certain embodiments, the system and method operate in a “pump-then-burst release” fashion to rapidly achieve high yields extracellularly. In certain embodiments, the system and method include quorum sensing-derived regulation, which may enable auto-induction of a protein's expression and secretion. |
| FILED | Friday, July 08, 2022 |
| APPL NO | 17/861150 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/19 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 5/10 (20130101) C12N 2500/02 (20130101) C12N 2510/00 (20130101) C12N 2523/00 (20130101) C12N 2529/00 (20130101) C12N 2533/10 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230038487 | Steinmetz et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicole Steinmetz (La Jolla, California); Hui Cai (La Jolla, California) |
| ABSTRACT | Disclosed herein, in certain embodiments, are engineered virus-like particles and compositions that comprise an oligodeoxynucleotide (ODN) for the treatment of a disease or condition. In some embodiments, also disclosed herein are methods of inducing phagocytosis of a target cell and methods of immune modulation. |
| FILED | Thursday, November 19, 2020 |
| APPL NO | 17/779484 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7125 (20130101) A61K 39/12 (20130101) Original (OR) Class A61K 39/39 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230038498 | XU et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhen XU (Ann Arbor, Michigan); Adita S. PANDEY (Ann Arbor, Michigan); Jonathan SUKOVICH (Ann Arbor, Michigan); Tyler GERHARDSON (Ann Arbor, Michigan); Sang Won CHOI (Ann Arbor, Michigan) |
| ABSTRACT | Methods and devices for producing cavitation in tissue are provided. Methods and devices are also provided for surgical navigation, including defining a target treatment zone and navigating a focus of a therapy transducer to the target treatment zone. Embodiments are provided for co-registering a plurality of surgical imaging and navigation systems. Systems for performing Histotripsy therapy are also discussed. |
| FILED | Thursday, January 07, 2021 |
| APPL NO | 17/790975 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 34/20 (20160201) Original (OR) Class A61B 34/30 (20160201) A61B 2090/364 (20160201) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230038631 | GALAZYUK |
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| FUNDED BY |
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| APPLICANT(S) | Northeast Ohio Medical University (Rootstown, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander V. GALAZYUK (Kent, Ohio) |
| ABSTRACT | A method of treating tinnitus in a subject is described that includes administering a therapeutically effective amount of a group II metabotropic glutamate receptor (mGluR) agonist to the subject. A method of screening a subject having tinnitus for treatment with a group II mGluR agonist that includes testing the use of residual inhibition to suppress tinnitus in the subject, wherein suppression of tinnitus by residual inhibition indicates that a group II mGluR agonist would be effective for treating tinnitus in the subject, is also described. |
| FILED | Monday, April 18, 2022 |
| APPL NO | 17/723313 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/196 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/16 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230038720 | Selsted et al. |
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| APPLICANT(S) | The University of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael E. Selsted (Pasadena, California); Dat Q. Tran (Alhambra, California); Justin B. Schaal (Orange, California) |
| ABSTRACT | Peptide analogs of θ-defensins have been developed that are effective in treating multi-drug resistant microbial infections when used at concentrations below those needed to provide a microbicidal effect. These peptides were found to modulate host defense mechanisms to increase clearance of microbial pathogens, enhance phagocytic activity, and enhance neutrophil recruitment while reducing inflammation. |
| FILED | Tuesday, September 20, 2022 |
| APPL NO | 17/948904 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/00 (20180101) Peptides C07K 7/64 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230038866 | Qi et al. |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaodong Qi (Chandler, Arizona); Hao Yan (Chandler, Arizona); Peter Nakaji (Phoenix, Arizona); Joseph Georges (Mesa, Arizona); Xiaowei Liu (Tempe, Arizona) |
| ABSTRACT | Disclosed are methods of detecting and treating suspected B-cell lymphoma. |
| FILED | Friday, July 22, 2022 |
| APPL NO | 17/814407 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/115 (20130101) C12N 2310/16 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5308 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230039153 | Cheng et al. |
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| FUNDED BY |
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| APPLICANT(S) | Trustees of Boston University (Boston, Massachusetts); Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | Trustees of Boston University (Boston, Massachusetts); Northwestern University (Evanston, Illinois) |
| INVENTOR(S) | Ji-Xin Cheng (Newton, Massachusetts); Junjie Li (Arlington, Massachusetts); Yuying Tan (Allston, Massachusetts); Daniela Matei (Chicago, Illinois); Guangyuan Zhao (Chicago, Illinois) |
| ABSTRACT | Disclosed is an assay for determining resistance in a target cell or tissue to a therapy associated with cellular stress using chemical microscopy and high-throughput single cell analysis to determine functional metabolic alteration, including determining metabolic reprogramming in a target cell or tissue to a therapy associated with cellular stress, and methods of using the assays. |
| FILED | Monday, June 13, 2022 |
| APPL NO | 17/839080 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/30 (20130101) G01N 27/416 (20130101) G01N 33/492 (20130101) Original (OR) Class G01N 33/48735 (20130101) G01N 2800/52 (20130101) Scanning-probe Techniques or Apparatus; Applications of Scanning-probe Techniques, e.g Scanning Probe Microscopy [SPM] G01Q 60/60 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/10 (20180101) G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230039246 | HOSSAN et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Central Oklahoma (Edmond, Oklahoma) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mohammad Robiul HOSSAN (Edmond, Oklahoma); Seth HARRIET (Edmond, Oklahoma); Andrew M. BAUER (Jones, Oklahoma) |
| ABSTRACT | A biodegradable flow diverting device (BFDD) that will regulate blood flow into an aneurysmal sac, act as a scaffold for endothelization at the neck of an aneurysm, and degrade after successful dissolution of aneurysm and remodeling of blood vessel. This BFDD and associated fabrication method have the following features: (1) This is a non-braided FDD. The pore shapes, sizes, architectures (especially at the inlet and outlet of the pores), pore densities and porosities can be controlled for the optimum performance depending on the blood vessel and aneurysmal morphologies from patient MRI images, (2) BFDD is developed on a rotary arm with programmable variable speed and diameter in conjunction with a micromotion stage (3) Fabrication system can take any material including blended/composite biomaterials by adjusting temperature of the electro-melt extruder/needle and (4) Fabrication system is compatible with CAM (computer aided manufacturing) software and able to operate based on the adapted G-code. |
| FILED | Friday, July 22, 2022 |
| APPL NO | 17/871001 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/12113 (20130101) Original (OR) Class A61B 17/12131 (20130101) A61B 2017/00004 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/118 (20170801) B29C 64/393 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 30/00 (20141201) B33Y 50/02 (20141201) B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230039352 | Schnappinger et al. |
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| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dirk Schnappinger (New York, New York); Sabine Ehrt (New York, New York) |
| ABSTRACT | Conditionally replicating recombinant cells, compositions and vaccines having the cells, and methods of using the cells, are provided. |
| FILED | Friday, January 08, 2021 |
| APPL NO | 17/791835 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/04 (20130101) Original (OR) Class A61K 2039/523 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/06 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 15/74 (20130101) C12N 15/635 (20130101) C12N 2800/101 (20130101) C12N 2830/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230039421 | Bellinger et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Andrew Bellinger (Wellesley, Massachusetts); Shiyi Zhang (Shanghai, China PRC); Carlo Giovanni Traverso (Newton, Massachusetts); Robert S. Langer (Newton, Massachusetts); Stacy Mo (Darien, Illinois); Tyler Grant (Arlington, Massachusetts); Mousa Jafari (Waltham, Massachusetts); Dean Liang Glettig (Cambridge, Massachusetts); Angela DiCiccio (San Francisco, California); Lowell L. Wood, JR. (Bellevue, Washington); Philip A. Eckhoff (Kirkland, Washington) |
| ABSTRACT | Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time. |
| FILED | Thursday, June 09, 2022 |
| APPL NO | 17/836972 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/48 (20130101) A61K 9/0053 (20130101) A61K 9/0065 (20130101) Original (OR) Class A61K 31/65 (20130101) A61K 31/357 (20130101) A61K 31/7048 (20130101) A61K 47/10 (20130101) A61K 47/32 (20130101) A61K 47/34 (20130101) A61K 47/40 (20130101) A61K 47/42 (20130101) A61K 47/58 (20170801) A61K 47/6901 (20170801) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 31/002 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/73 (20130101) C08G 18/4277 (20130101) C08G 63/08 (20130101) C08G 83/006 (20130101) C08G 2230/00 (20130101) Compositions of Macromolecular Compounds C08L 33/02 (20130101) C08L 33/08 (20130101) C08L 33/14 (20130101) C08L 2203/02 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230039456 | Nakhasi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Gregory Matlashewski (Montreal, Canada); Wen-Wei Zhang (Montreal, Canada); Patrick Lypaczewski (Montreal, Canada); The U.S.A., as represented by the Secretary, Department of Health and Human Services (Silver Spring, Maryland); Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Silver Spring, Maryland); Ohio State Innovation Foundation (Columbus, Ohio) |
| INVENTOR(S) | Hira L. Nakhasi (Potomac, Maryland); Ranadhir Dey (Potomac, Maryland); Sreenivas Gannavaram (Potomac, Maryland); Subir Karmakar (Potomac, Maryland); Gregory Matlashewski (Hudson, Canada); Abhay Satoskar (Upper Arlington, Ohio); Wen-Wei Zhang (Dorval, Canada); Patrick Lypaczewski (Montréal, Canada) |
| ABSTRACT | Disclosed herein are modified Leishmania species and compositions thereof, such as live, attenuated organisms, immunogenic compositions, vaccines, and pharmaceutical compositions. Further disclosed are methods related to the modified Leishmania species, such as methods of production and methods of use. |
| FILED | Thursday, December 17, 2020 |
| APPL NO | 17/786129 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/008 (20130101) Original (OR) Class A61K 2039/522 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 33/02 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/105 (20210501) C12N 15/63 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230039492 | Celedon et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Scanogen Inc. (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alfredo Andres Celedon (Columbia, Maryland); Saravana Radha Krishna Murthy (Gaithersburg, Maryland); Zhiguang Xu (Baltimore, Maryland); Danielle Elise Schultz (Gaithersburg, Maryland); Troy Allen Horn (Reisterstown, Maryland) |
| ABSTRACT | The present application relates to detection units and methods for detecting one or more target analytes in a sample using a complex formed by a target and first and second probes, wherein the complex comprises an elongated region, a particle that is coupled to the first probe, and a solid support that is coupled to the second probe. Specific binding of a target analyte can be distinguished from non-specific binding of the particle by measuring the displacement of the particle. |
| FILED | Tuesday, October 25, 2022 |
| APPL NO | 17/973055 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6816 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/745 (20130101) G01N 27/3271 (20130101) G01N 27/3276 (20130101) G01N 27/4145 (20130101) G01N 33/54306 (20130101) G01N 33/54313 (20130101) G01N 33/54326 (20130101) G01N 33/54373 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230039502 | Prossnitz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric R. Prossnitz (Albuquerque, New Mexico); Jeffrey B. Arterburn (Las Cruces, New Mexico); Cristian Bologa (Albuquerque, New Mexico) |
| ABSTRACT | The current invention is in the field of molecular biology/pharmacology and provides novel 3-oxabicyclo[3.3.1]nonene compounds and derivatives that modulate the effects of the classical estrogen receptors alpha and beta (ERalpha and ERbeta) with little to no biological or physiological effects on the G protein-coupled estrogen receptor GPER (also known as GPR30). These compounds may function as agonists and/or antagonists of one or more of the disclosed classical estrogen receptors. Diseases that are mediated through one or more of these receptors include cancer (including but not limited to breast (particularly endocrine or anti-hormone resistant, and for the prevention/reduction of endocrine or anti-hormone resistance), reproductive and other hormone-dependent cancers, leukemia, colon cancer, prostate cancer), reproductive (genito-urological) including endometritis, prostatitis, polycystic ovarian syndrome, bladder control, hormone-related disorders, hearing disorders, cardiovascular conditions including hot flashes and profuse sweating, hypertension, stroke, obesity, osteoporosis, hematologic diseases, vascular diseases or conditions such as venous thrombosis, atherosclerosis, among numerous others and disorders of the central and peripheral nervous system, including depression, insomnia, anxiety, multiple sclerosis, neuropathy, neurodegenerative disorders (such as Parkinson's disease and Alzheimer's disease), as well as inflammatory bowel disease, Crohn's disease, coeliac (celiac) disease and related disorders of the intestine, among numerous others as described herein. A contraceptive indication to prevent or reduce the likelihood of pregnancy after intercourse is a further aspect of the present invention. |
| FILED | Wednesday, August 19, 2020 |
| APPL NO | 17/634293 |
| CURRENT CPC | Heterocyclic Compounds C07D 311/94 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230039515 | Lux et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | The Board of Regents of The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Caroline de Gracia Lux (Austin, Texas); Jacques Lux (Austin, Texas); Alexander M. Vezeridis (Austin, Texas); Robert F. Mattrey (Austin, Texas) |
| ABSTRACT | Stable perfluorocarbon nanodroplet compositions with properties such as low-boiling points and small particle diameters are provided for improved performance in ultrasound imaging and therapeutic applications. Methods of producing stabilized nanodroplet compositions and methods of using the compositions are further provided to allow for improved performance in ultrasound imaging techniques and/or therapeutic applications. |
| FILED | Monday, August 08, 2022 |
| APPL NO | 17/882797 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/225 (20130101) Original (OR) Class A61K 49/226 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230039520 | SATPATHY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ansuman SATPATHY (Stanford, California); Howard Y. CHANG (Stanford, California); Kevin R. PARKER (Stanford, California) |
| ABSTRACT | Methods and systems to reduce neurotoxicity associated with the treatment of CD19+ B-cell hyperproliferative disorders are disclosed. Neurotoxicity is reduced by the use of agents that protect CD19+ neurovascular pericytes and/or CD19+ vSMCs from attack by CD19-targeted therapy, and by modification of CD19-targeted therapy to avoid CD19+ pericytes and/or CD19+ vSMCs. |
| FILED | Thursday, January 14, 2021 |
| APPL NO | 17/793024 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Peptides C07K 14/70532 (20130101) C07K 16/44 (20130101) C07K 16/289 (20130101) C07K 16/2803 (20130101) C07K 16/2818 (20130101) Original (OR) Class C07K 16/2896 (20130101) C07K 2317/31 (20130101) C07K 2317/569 (20130101) C07K 2317/622 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1138 (20130101) C12N 2310/14 (20130101) C12N 2310/531 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230039604 | MARKOWITZ et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RODEO THERAPEUTICS CORPORATION (Seattie, Washington); Case Western Reserve University (Cleveland, Ohio); Board of Regents of the University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sanford MARKOWITZ (Pepper Pike, Ohio); Joseph READY (Carrolton, Texas); Stephen L. GWALTNEY, II (Chapel Hill, North Carolina); Monika ANTCZAK (Forth Worth, Texas) |
| ABSTRACT | Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein. |
| FILED | Thursday, November 21, 2019 |
| APPL NO | 17/296055 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/437 (20130101) A61K 31/501 (20130101) A61K 31/506 (20130101) A61K 31/519 (20130101) A61K 31/541 (20130101) A61K 31/4365 (20130101) Original (OR) Class A61K 31/5377 (20130101) A61K 45/06 (20130101) Heterocyclic Compounds C07D 495/04 (20130101) C07D 519/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230039899 | Larman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Harry Larman (Baltimore, Maryland); Joel Credie (Gaithersburg, Maryland) |
| ABSTRACT | The present invention relates to the field of ribonucleotide analysis. More specifically, the present invention provides compositions and methods for detection for nucleic acids using probe pair litigation. In particular embodiments, the compositions and methods of the present invention utilize a probe set comprising (1) a first multi-partite probe comprising a 5′ phosphorylated donor probe and a first bridge probe, wherein the 5′ phosphorylated donor probe specifically hybridizes to a target nucleic acid; and (ii) a second multi-partite probe comprising a 3′ acceptor probe and a second bridge probe, wherein the 3′ acceptor probe specifically hybridizes to the target nucleic acid adjacent to the 5′ donor probe and the second bridge probe is 5′ phosphorylated. |
| FILED | Monday, January 04, 2021 |
| APPL NO | 17/790293 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6841 (20130101) Original (OR) Class C12Q 1/6844 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230039930 | KAUFMAN |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sanford Burnham Prebys Medical Discovery Institute (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Randal J. KAUFMAN (San Diego, California) |
| ABSTRACT | Models and methods related to targeting binding immunoglobulin protein (BiP) are described, where the models and methods allow identification and analysis of protein folding and misfolding. |
| FILED | Thursday, December 31, 2020 |
| APPL NO | 17/790052 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0278 (20130101) Original (OR) Class A01K 2217/052 (20130101) A01K 2217/072 (20130101) A01K 2227/105 (20130101) A01K 2267/0393 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230039997 | VLAAR et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PUERTO RICO (San Juan, Puerto Rico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cornelis P. VLAAR (San Juan, Puerto Rico); Suranganie DHARMAWARDHANE FLANAGAN (San Juan, Puerto Rico); Eliud HERNANDEZ-O'FARRILL (San Juan, Puerto Rico); Linette CASTILLO-PICHARDO (San Juan, Puerto Rico) |
| ABSTRACT | Compounds are disclosed that inhibit RhoGTPases that are useful for inhibiting hyperprofilerative and neoplastic diseases. Specifically, the compounds inhibit the GTPases Rac and Cdc42 that are overactive or overexpressed in signaling pathways in cancer and metastasis. Methods for treatment of cancer and hyperproliferative diseases are disclosed. |
| FILED | Wednesday, July 13, 2022 |
| APPL NO | 17/864198 |
| CURRENT CPC | Heterocyclic Compounds C07D 401/14 (20130101) C07D 403/04 (20130101) C07D 403/14 (20130101) C07D 409/14 (20130101) C07D 491/048 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230040112 | KILGARD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael P. KILGARD (Richardson, Texas); Navzer ENGINEER (Plano, Texas); David PIERCE (Plano, Texas) |
| ABSTRACT | A method (of treating a patient who has tinnitus) includes: providing to the patient a series of tones including at least a single tone which is at least a half-octave outside a tinnitus frequency of the patient; and applying vagus nerve stimulation to the patient to induce a period of plasticity in a cortex of the patient that is transitory and that represents a transitory opportunity for learning to occur; and wherein the at least a single tone occurs during the transitory opportunity for learning. |
| FILED | Tuesday, October 18, 2022 |
| APPL NO | 17/968021 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/128 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 11/00 (20130101) Original (OR) Class Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/361 (20130101) A61N 1/0551 (20130101) A61N 1/36053 (20130101) A61N 1/36167 (20130101) A61N 1/36171 (20130101) A61N 1/36178 (20130101) A61N 1/37235 (20130101) A61N 1/37247 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 23/28 (20130101) Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 25/75 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230040125 | Nathanson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of The University Of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David A. Nathanson (Los Angeles, California); Timothy F. Cloughesy (Calabasas, California); Elizabeth Fernandez (Los Angeles, California); Wilson X. Mai (Sunnyvale, California) |
| ABSTRACT | The present disclosure relates to a method of treating a glioblastoma by conjointly administering to a subject a BCL-xL inhibitor and a second therapy such as an alkylating agent, irradiation, or an MCL-1 inhibitor. |
| FILED | Wednesday, December 23, 2020 |
| APPL NO | 17/789019 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/53 (20130101) A61K 31/519 (20130101) A61K 31/4725 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230040261 | Beisel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chase Lawrence Beisel (Raleigh, North Carolina); Scott Collins (Raleigh, North Carolina) |
| ABSTRACT | The present disclosure provides compositions, methods, and systems related to genome editing technology. In particular, the present disclosure provides a novel CRISPR-based genome editing technology that involves the generation of abasic sites to facilitate genetic recombination, without the need for breaks in the DNA. The compositions, methods, and systems described herein address many of the drawbacks of currently available approaches, including off-target effects and cellular toxicity. |
| FILED | Tuesday, March 09, 2021 |
| APPL NO | 17/905934 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/102 (20130101) Original (OR) Class C12N 15/907 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230040370 | Thakor et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Avnesh S. Thakor (Palo Alto, California); Mehdi Razavi (Palo Alto, California) |
| ABSTRACT | A bioscaffold comprising a graphene matrix for use in cellular therapy is disclosed. In particular, a bioscaffold having a coating of dexamethasone on a three-dimensional graphene matrix is provided, wherein the bioscaffold elutes dexamethasone to reduce inflammatory responses following implantation of the bioscaffold in a subject. Having the dexamethasone released locally in the vicinity of the bioscaffold avoids the systemic side effects from conventional intravenous delivery while allowing the dexamethasone to modulate the inflammatory milieu within the transplantation microenvironment. |
| FILED | Wednesday, July 27, 2022 |
| APPL NO | 17/815485 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/7007 (20130101) A61K 31/573 (20130101) A61K 35/28 (20130101) A61K 35/39 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/08 (20130101) Original (OR) Class A61L 27/18 (20130101) A61L 27/54 (20130101) A61L 27/56 (20130101) A61L 27/58 (20130101) A61L 27/3804 (20130101) A61L 27/3834 (20130101) A61L 2300/43 (20130101) A61L 2300/606 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230040418 | Myung et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); The United States Government as Represented by The Department of Veterans Affairs (NW Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Myung (Saratoga, California); Sei Kwang Hahn (Redwood City, California); Amy C. Madl (Los Altos, California) |
| ABSTRACT | Compositions and methods are provided for lamellar and defect reconstruction of corneal stromal tissue using supramolecular complexes that form a defined gel structure in situ. Such gels can serve as cellular or acellular matrices with or without certain encapsulated therapeutic factors to facilitate tissue regeneration such as multilayered re-epithelialization of wounded corneal stromal tissue. |
| FILED | Wednesday, February 24, 2021 |
| APPL NO | 17/760083 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/145 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/25 (20130101) A61K 31/728 (20130101) A61K 35/30 (20130101) Peptides C07K 5/1016 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230040528 | Bhatia et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Sangeeta N. Bhatia (Lexington, Massachusetts); Darrell J. Irvine (Arlington, Massachusetts); Karl Dane Wittrup (Chestnut Hill, Massachusetts); Andrew David Warren (Cambridge, Massachusetts); Jaideep S. Dudani (Cambridge, Massachusetts); Naveen K. Mehta (Cambridge, Massachusetts) |
| ABSTRACT | In some aspects, the disclosure provides compositions and methods for detecting and monitoring the activity of proteases in vivo using affinity assays. The disclosure relates, in part, to the discovery that biomarker nanoparticles targeted to the lymph nodes of a subject are useful for the diagnosis and monitoring of certain medical conditions (e.g., metastatic cancer, infection with certain pathogenic agents). |
| FILED | Tuesday, August 02, 2022 |
| APPL NO | 17/816765 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Peptides C07K 7/00 (20130101) C07K 7/06 (20130101) C07K 7/08 (20130101) C07K 14/001 (20130101) C07K 2319/31 (20130101) C07K 2319/50 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/37 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) G01N 33/5088 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230040568 | ZANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Albert Einstein College of Medicine (Bronx, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xingxing ZANG (New York, New York); Yao WEI (Larchmont, New York); Xiaoxin REN (Bronx, New York); Scott MOERDLER (New York, New York) |
| ABSTRACT | Described herein are antibodies, immunogenic fragments and compositions thereof targeting the killer-cell immunoglobulin-like receptor protein KIR3DL3, as well as methods of using the same for the treatment of human diseases including cancer. In certain embodiments, the disclosure relates to an antibody or an immunogenic fragment thereof that specifically binds to KIR3DL3 protein, wherein the antibody or the immunogenic fragment thereof specifically binds to a KIR3DL3 epitope comprising the whole extracellular domain or a portion thereof. |
| FILED | Thursday, October 01, 2020 |
| APPL NO | 17/753731 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/3955 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2803 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/24 (20130101) C07K 2319/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230040639 | Azhar |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of South Carolina (Columbia, South Carolina) |
| ASSIGNEE(S) | University of South Carolina (Columbia, South Carolina) |
| INVENTOR(S) | Mohamad Azhar (lrmo, South Carolina) |
| ABSTRACT | The current disclosure has identified novel developmental, cellular, molecular, and biochemical pathways and developed a unique mouse model which recapitulates age, bicuspid aortic valve-associated, and gender-specific pathological aspects of development and progression of human CAVD, which will be useful in developing novel diagnostic, preventative, and therapeutic strategies for CAVD patients. |
| FILED | Friday, October 30, 2020 |
| APPL NO | 17/783381 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0278 (20130101) Original (OR) Class A01K 2217/15 (20130101) A01K 2217/052 (20130101) A01K 2217/206 (20130101) A01K 2227/105 (20130101) A01K 2267/0375 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230041065 | Shah et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Brigham and Women`s Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dhvanit I. Shah (Malden, Massachusetts); Giorgia Scapin (Boston, Massachusetts) |
| ABSTRACT | In the various aspects and embodiments, this disclosure provides genetic, pharmacological, and mechanical stimuli for transitioning endothelial cells to hemogenic endothelial (HE) cells, and for transitioning HE cells to HSCs, including HSCs that comprise a significant level of LT-HSCs. The disclosure further provides methods for expanding HSCs using the genetic, pharmacological, and mechanical stimuli. |
| FILED | Wednesday, December 09, 2020 |
| APPL NO | 17/783694 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0647 (20130101) Original (OR) Class C12N 2506/11 (20130101) C12N 2506/28 (20130101) C12N 2506/45 (20130101) C12N 2527/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230041099 | Hatoum |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of The University of Alabama (Tuscaloosa, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Asma Hatoum (Northport, Alabama) |
| ABSTRACT | The present disclosure relates to CRISPR-Cas10 systems and methods for phage genome editing. |
| FILED | Friday, September 16, 2022 |
| APPL NO | 17/932915 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/205 (20210501) C12N 9/22 (20130101) C12N 9/1276 (20130101) C12N 15/11 (20130101) C12N 15/74 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 15/902 (20130101) C12N 2310/20 (20170501) C12N 2710/00042 (20130101) C12N 2710/00045 (20130101) C12N 2795/10121 (20130101) C12N 2795/10221 (20130101) C12N 2795/10321 (20130101) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/44 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230041228 | Disney |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew D. Disney (Jupiter, Florida) |
| ABSTRACT | Herein, we describe the identification of a small molecule named Targapremir-210 that binds to the Dicer site of the miR-210 hairpin precursor. This interaction inhibits production of the mature miRNA, de-represses glycerol-3-phosphate dehydrogenase 1-like enzyme (GPD1 L), a hypoxia-associated protein negatively regulated by miR-210, decreases HIF-1 a, and triggers apoptosis of triple negative breast cancer cells only under hypoxic conditions. Further, Targapremir-210 inhibits tumorigenesis in a mouse xenograft model of hypoxic triple negative breast cancer. We applied Chemical Cross-Linking and Isolation by Pull Down (Chem-CLIP) to study the cellular selectivity and the on- and off-targets of Targapremir-210. Targapremir-210 selectively recognizes the miR-210 precursor and can differentially recognize RNAs in cells that have the same target motif but have different expression levels, revealing this important feature for selectively drugging RNAs for the first time. |
| FILED | Friday, February 16, 2018 |
| APPL NO | 16/486211 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/496 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230041334 | HOFFMAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BEHAVIORAL DIAGNOSTICS, LLC (Iowa City, Iowa); UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa) |
| ASSIGNEE(S) | BEHAVIORAL DIAGNOSTICS, LLC (Iowa City, Iowa); UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa) |
| INVENTOR(S) | Eric A. HOFFMAN (Iowa City, Iowa); Albert Tao-man LEUNG (Ringoes, New Jersey); Alejandro Comellas (Iowa City, Iowa); Alicia GERKE (Iowa City, Iowa); Robert PHILIBERT (Iowa City, Iowa) |
| ABSTRACT | This disclosure describes the use of a phosphodiesterase-5 (PDE5) inhibitor to reduce an individual's desire to smoke and/or frequency of smoking. In some embodiments, the PDE5 inhibitor is sildenafil (e.g., Viagra). |
| FILED | Friday, November 13, 2020 |
| APPL NO | 17/776968 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/352 (20130101) A61K 31/519 (20130101) Original (OR) Class A61K 31/4162 (20130101) A61K 31/5375 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/34 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230041359 | Rigoutsos et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THOMAS JEFFERSON UNIVERSITY (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Isidore Rigoutsos (Astoria, New York); Phillipe Loher (Philadelphia, Pennsylvania); Eric Londin (Philadelphia, Pennsylvania) |
| ABSTRACT | Disclosed herein are novel compositions, methods, and systems for determining whether a subject has, or is at risk of developing, or is at a given stage of a condition afflicting a tissue of interest, or determining the tissue or cell provenance of a biological sample, based on expression level of one or more of the novel miRNA and isomiR sequences disclosed herein. The compositions, methods, and systems described herein can be used to diagnose a disease or disorder, or prognose a given stage and/or progression of the disease or disorder, or determine the identity of the tissue or cell in a sample. In some embodiments, the compositions, methods, and systems described herein can be used to develop a treatment for the disease or disorder. For example, in some embodiments, the novel miRNAs can be used as therapeutics for treatment of a disease or disorder. |
| FILED | Friday, July 16, 2021 |
| APPL NO | 17/378274 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) C12Q 2600/178 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230041450 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF CONNECTICUT (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Changchun Liu (Farmington, Connecticut); Ziyue Li (Storrs, Connecticut) |
| ABSTRACT | Described herein is an immobilization-free, electrochemical method of detecting a target DNA sequence in a sample. The method includes: incubating the sample with a detection mixture, applying an electric field including an alternating current electric field and a direct current offset to the detection mixture to concentrate nucleic acids in the sample and the nucleic acid probe on a positively charged working electrode, wherein a Class 2 Cas protein trans-cleaved electroactive probe is released from the nucleic acid probe when the target DNA is present in the sample and diffuses toward a negatively charged electrode; and measuring the current as potential is applied, wherein detection of a current in the detection mixture indicates the presence of the target DNA sequence in the sample. |
| FILED | Friday, July 15, 2022 |
| APPL NO | 17/812876 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6823 (20130101) C12Q 1/6825 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/3276 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230041523 | Lasmézas et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Scripps Research Institute (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Corinne Lasmézas (Palm Beach Gardens, California); Minghai Zhou (Jupiter, Florida); Thomas D. Bannister (Palm Beach Gardens, Florida) |
| ABSTRACT | Compounds described herein may be used for the treatment of neurodegenerative diseases linked to protein misfolding, including prion diseases, Alzheimer's disease, Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS), and also other neurodegenerative, degenerative, metabolic and ischemic conditions. Indeed, NAD metabolism impairment is also a critical feature in brain ischemia/reperfusion injury, Wallerian degeneration, kidney failure, multiple sclerosis, aging, and metabolic disorders such as diabetes mellitus. Therapies that elevate or stabilize NAD levels may thus have broad potential for treating many severely debilitating neurological and metabolic conditions. Evidence is provided herein with compounds from 8 lead series for NAD restoring properties and for therapeutic efficacy in cellular and/or animal models of prion disease, PD and ALS. |
| FILED | Thursday, May 14, 2020 |
| APPL NO | 17/610758 |
| CURRENT CPC | Heterocyclic Compounds C07D 217/04 (20130101) C07D 217/10 (20130101) C07D 277/42 (20130101) C07D 311/30 (20130101) C07D 401/06 (20130101) C07D 401/14 (20130101) C07D 405/14 (20130101) C07D 413/14 (20130101) C07D 417/04 (20130101) C07D 471/04 (20130101) C07D 487/04 (20130101) Original (OR) Class C07D 513/04 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 17/07 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230041576 | Chen et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Beibei Chen (Sewickley, Pennsylvania); Toren Finkel (Pittsburgh, Pennsylvania); Yuan Liu (Sewickley, Pennsylvania) |
| ABSTRACT | This document provides compounds that are inhibitors of NF-κB activity, as well as the methods of using such compounds for treating diseases and conditions such as cancer, inflammatory conditions, or autoimmune diseases. |
| FILED | Friday, November 20, 2020 |
| APPL NO | 17/778492 |
| CURRENT CPC | Heterocyclic Compounds C07D 213/71 (20130101) C07D 215/36 (20130101) Original (OR) Class C07D 215/40 (20130101) C07D 217/24 (20130101) C07D 241/42 (20130101) C07D 263/46 (20130101) C07D 265/36 (20130101) C07D 267/14 (20130101) C07D 277/36 (20130101) C07D 311/12 (20130101) C07D 401/12 (20130101) C07D 403/04 (20130101) C07D 403/12 (20130101) C07D 471/04 (20130101) C07D 487/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230041644 | MISSIAKAS et al. |
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| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | The University of Chicago (Chicago, Illinois) |
| INVENTOR(S) | Dominique M. MISSIAKAS (Chicago, Illinois); Olaf SCHNEEWIND (Chicago, Illinois); Xinhai CHEN (Naperville, Illinois) |
| ABSTRACT | The current disclosure provides novel compositions for treating bacterial infections. Accordingly, aspects of the disclosure relate to an engineered antibody comprising: LCDR1, LCDR2, and LCDR3 of the light chain variable region of the 3F6 antibody and HCDR1, HCDR2, and HCDR3 of the heavy chain variable region of the 3F6 antibody. Also provided are compositions comprising the antibodies and nucleic acids encoding either the heavy chain or light chain (or both) of the antibodies. Other aspects relate to host cells comprising the antibodies and/or nucleic acids of the disclosure. Further aspects relate to a method of preventing or treating staphylococcal infection comprising the step of administering the antibody of the disclosure to a subject in need thereof. Yet further aspects relate to a method of making the antibody comprising expressing the nucleic acid(s) of the disclosure in a cell and isolating the expressed protein. |
| FILED | Friday, September 11, 2020 |
| APPL NO | 17/753692 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 16/464 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230041761 | Schiltz et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gary E. Schiltz (Naperville, Illinois); Iredia D. Iyamu (Evanston, Illinois); Rama K. Mishra (Chicago, Illinois); Wei Lv (Evanston, Illinois); Neha Malik (Evanston, Illinois) |
| ABSTRACT | This invention is in the field of medicinal chemistry. In particular, the invention relates to anew class of small-molecules having a tetrahydroindazole structure which function as modulators (e.g., activators or inhibitors) of sigma-1 and/or sigma-2 receptors, and their use as therapeutics for the treatment of cancer and other diseases (e.g., neurological conditions) characterized with sigma-1 and/or sigma-2 receptor activity. |
| FILED | Tuesday, November 26, 2019 |
| APPL NO | 17/296867 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/416 (20130101) A61K 31/422 (20130101) A61K 31/437 (20130101) A61K 31/454 (20130101) A61K 31/496 (20130101) A61K 31/506 (20130101) A61K 31/551 (20130101) A61K 31/4178 (20130101) A61K 31/4439 (20130101) A61K 31/4545 (20130101) A61K 31/4725 (20130101) A61K 31/4985 (20130101) A61K 31/5377 (20130101) A61K 47/55 (20170801) A61K 47/64 (20170801) Heterocyclic Compounds C07D 231/56 (20130101) Original (OR) Class C07D 401/12 (20130101) C07D 401/14 (20130101) C07D 403/12 (20130101) C07D 405/12 (20130101) C07D 413/12 (20130101) C07D 471/04 (20130101) C07D 487/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230042004 | Kumar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arun Kumar (San Diego, California); Supun Nakandala (San Diego, California) |
| ABSTRACT | A method may include generating views materializing tensors generated by a convolutional neural network operating on an image. Determining the outputs of the convolutional neural network operating on the image with a patch occluding various portions of the image. The outputs being determined by generating queries on the views that performs, based at least on the changes associated with occluding different portions of the image, partial re-computations of the views. A heatmap may be generated based on the outputs of the convolutional neural network. The heatmap may indicate the quantities to which the different portions of the image contribute to the output of the convolutional neural network operating on the image. Related systems and articles of manufacture, including computer program products, are also provided. |
| FILED | Friday, February 05, 2021 |
| APPL NO | 17/784620 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/24535 (20190101) Image or Video Recognition or Understanding G06V 10/82 (20220101) Original (OR) Class G06V 10/751 (20220101) G06V 10/759 (20220101) G06V 20/41 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230042042 | Schafmeister et al. |
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| FUNDED BY |
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| APPLICANT(S) | Temple University-Of The Commonwealth System of Higher Education (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christian Schafmeister (Philadelphia, Pennsylvania); Justin Northrup (Philadelphia, Pennsylvania) |
| ABSTRACT | This invention provides unnatural amino acids as well as amino acid sequences, foldamers, macrocycles, and formulations comprising said unnatural amino acids. In one aspect of the invention, the unnatural amino acids or the formulation thereof are used to mimic natural amino acids or the formulations thereof in a subject in need thereof. |
| FILED | Thursday, December 17, 2020 |
| APPL NO | 17/785184 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4166 (20130101) Heterocyclic Compounds C07D 487/10 (20130101) Original (OR) Class C07D 487/20 (20130101) C07D 487/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230042198 | Rao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | La Jolla Institute for Immunology (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anjana Rao (La Jolla, California); Isaac F. Lopez-Moyado (La Jolla, California) |
| ABSTRACT | The present invention includes a method of increasing, stimulating, inducing, promoting, enhancing or maintaining the genomic stability of a cell of a subject, the method comprising decreasing, reducing, inhibiting, suppressing, limiting or controlling loss of methylation of heterochromatin in the cell and/or modulating heterochromatin dysfunction in a cell of a subject, the method comprising activating, eliciting, stimulate ng, inducing, promoting, increasing or enhancing expression or activity in the cell of one or more DNA methyltransferase (DNMT). |
| FILED | Wednesday, November 25, 2020 |
| APPL NO | 17/779392 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/44 (20130101) Original (OR) Class A61K 38/45 (20130101) A61K 38/1709 (20130101) Peptides C07K 16/40 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) C12N 2310/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230042314 | Shih et al. |
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| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yen-Yu Shih (Cary, North Carolina); Martin John MacKinnon (Raleigh, North Carolina); Yuncong Ma (Chapel Hill, North Carolina); Wei-Tang Chang (Chapel Hill, North Carolina) |
| ABSTRACT | This specification describes systems and methods for using Zero Echo Time (ZTE) magnetic resonance imaging (MRI) sequences for applications to functional MRI (fMRI). In some examples, a system for functional magnetic resonance imaging includes a magnetic resonance imaging (MRI) scanner and a control console implemented on at least one processor. The control console is configured for executing, using the MRI scanner, a zero echo time (ZTE) pulse sequence; acquiring, using the MRI scanner, magnetic resonance data in response to the ZTE pulse sequence; and constructing at least one MRI image using the magnetic resonance data and measuring tissue oxygenation (PtO2)-related T1 changes as a proxy of neural activity changes of a subject using the at least one MRI image. |
| FILED | Monday, August 08, 2022 |
| APPL NO | 17/882965 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) Original (OR) Class Measuring Electric Variables; Measuring Magnetic Variables G01R 33/48 (20130101) G01R 33/4824 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230042429 | Kagan |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Children`s Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan C. Kagan (Brookline, Massachusetts) |
| ABSTRACT | The present invention provides methods and compositions for specific activation of inflammatory responses in dendritic cells (DCs). 1-palmitoyl-2-arachidonyl-sn-glycero phosphorylcholine (PAPC) and its oxidized variant (oxPAPC) were identified to promote DC-mediated immunity, and are provided as adjuvants in immunostimulatory compositions, including vaccines. |
| FILED | Tuesday, April 26, 2022 |
| APPL NO | 17/730030 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) Original (OR) Class A61K 2039/55572 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230042446 | USHERWOOD et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edward USHERWOOD (Hanover, New Hampshire); Young-Kwang USHERWOOD (Hanover, New Hampshire) |
| ABSTRACT | Provided are methods, compositions, and cells for use in adoptive cell therapy for the treatment of cancer. The methods involve administering an effective amount of cells to a subject, wherein the cells are modified ex vivo to suppress endogenous Zbtb20 expression and/or activity within the modified cells. The cells may comprise a dominant negative Zbtb20 capable of suppressing endogenous Zbtb20 activity, at least one shRNA capable of suppressing endogenous Zbtb20 expression, or at least one sgRNA capable of suppressing endogenous Zbtb20 expression. The cells may further comprise an exogenous TCR and/or CAR suitable for treating cancer. The method can further involve administering one or more additional cancer therapies, such as cells which express at least one exogenous TCR and/or CAR suitable for treating cancer. The method can provide various advantages, such as a reduction and/or elimination of an amount of cancer cells in the subject. |
| FILED | Friday, December 04, 2020 |
| APPL NO | 17/782252 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/4702 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) C12N 15/1138 (20130101) C12N 2310/14 (20130101) C12N 2310/20 (20170501) C12N 2310/531 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230042624 | Gilbert et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Luke A. Gilbert (San Francisco, California); Max Horlbeck (Oakland, California); Martin Kampmann (Oakland, California); Lei S. Qi (San Francisco, California); Jonathan S. Weissman (San Francisco, California) |
| ABSTRACT | Methods, compositions, and kits are provided for CRISPR/Cas mediated transcriptional modulation. |
| FILED | Monday, January 24, 2022 |
| APPL NO | 17/582820 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) C12N 15/102 (20130101) C12N 15/1079 (20130101) Original (OR) Class C12N 15/1082 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6897 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230042710 | FORD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | INNAMED, INC. (Philadelphia, Pennsylvania); AUBURN UNIVERSITY (Auburn, Alabama) |
| ASSIGNEE(S) | INNAMED, INC. (Philadelphia, Pennsylvania); AUBURN UNIVERSITY (Auburn, Alabama) |
| INVENTOR(S) | Katarena I. FORD (Auburn, Alabama); Niamat E. KHUDA (Auburn, Alabama); Asanka GURUKANDURE GEDARA (Auburn, Alabama); Christopher J. EASLEY (Auburn, Alabama); Subramaniam SOMASUNDARAM (Auburn, Alabama); Anup SINGH (Philadelphia, Pennsylvania); Eshwar INAPURI (Philadelphia, Pennsylvania) |
| ABSTRACT | Described herein are nucleic acid-based electrochemical proximity assays (ECPAs) for sample quantification. The invention may also include a biosensor with a sensing mechanism that uses a pair of aptamers or antibodies that bind the target of interest. More specifically, the invention relates to an electrochemical-based read out of a sensing mechanism that uses a nucleic acid-based proximity assay in conjunction with a pair of aptamers or antibodies for sample quantification. The biosensor or a set of biosensors can be used either as a standalone measurement system for a single analyte target or as a component of a multiplexed cartridge for multiple analytes. |
| FILED | Thursday, December 31, 2020 |
| APPL NO | 17/789161 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6825 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/3276 (20130101) G01N 27/3277 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230042830 | Chavali et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Venkata Ramana Murthy Chavali (Malvern, Pennsylvania); Jason Adam Mills (Chester Springs, Pennsylvania) |
| ABSTRACT | Compositions and methods for inducing pluripotent stem cells into retinal ganglion cells for administration to a subject for treating progressive optic neuropathies, thereby alleviating symptoms of such disorders including glaucoma. |
| FILED | Monday, July 18, 2022 |
| APPL NO | 17/867335 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0621 (20130101) Original (OR) Class C12N 2501/13 (20130101) C12N 2501/41 (20130101) C12N 2501/105 (20130101) C12N 2501/115 (20130101) C12N 2506/45 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230042953 | Wagner et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin Wagner (Madison, Wisconsin); Paul Laeseke (Madison, Wisconsin); Michael Speidel (Madison, Wisconsin) |
| ABSTRACT | A system and method are provided for creating an image including quantified flow within vessels of a subject. The method includes providing a single-sweep, three-dimensional (3D) image volume acquired from a subject during a single pass of a computed tomography (CT) imaging system as the subject receives a dose of a contrast agent and determining a phase shift corresponding to pulsatile contrast in vessels within the single-sweep, 3D image volume. The method further includes quantifying a flow through the vessels within the single-sweep, 3D image volume using the phase shift and generating a report including indicating flow through the vessels within the 3D image volume. |
| FILED | Friday, August 06, 2021 |
| APPL NO | 17/395980 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/02755 (20130101) Original (OR) Class A61B 6/037 (20130101) Image Data Processing or Generation, in General G06T 7/0016 (20130101) G06T 15/08 (20130101) G06T 2207/10081 (20130101) G06T 2207/30104 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230043198 | PALM et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | Yale University (New Haven, Connecticut) |
| INVENTOR(S) | Noah PALM (New Haven, Connecticut); Aaron RING (New Haven, Connecticut); Haiwei CHEN (New Haven, Connecticut) |
| ABSTRACT | Methods of identifying test compounds or mixtures of test compounds from microbiota that bind to a fusion protein, such as a G-protein coupled receptor, are described. Also described are methods for high throughput screening of microbiota metabolites that are capable of activating G-protein coupled receptors. |
| FILED | Monday, December 09, 2019 |
| APPL NO | 17/312260 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) C12Q 1/6897 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230043330 | Hu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | Longqin Hu (Belle Mead, New Jersey); Haifa Albanyan (Riyadh, Saudi Arabia) |
| ABSTRACT | This document discloses novel cystine analogs, methods of making cystine analogs, compositions containing cystine analogs and methods of using such analogs for inhibiting cystine stone formation and treatment of cystinuria. |
| FILED | Friday, December 11, 2020 |
| APPL NO | 17/757244 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 323/41 (20130101) Heterocyclic Compounds C07D 211/58 (20130101) C07D 241/04 (20130101) C07D 295/13 (20130101) C07D 295/185 (20130101) Original (OR) Class C07D 471/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230043374 | Christiano et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| INVENTOR(S) | Angela M. Christiano (Mahwah, New Jersey); Raphael Clynes (West Nyack, New York) |
| ABSTRACT | The invention provides for methods for treating a hair loss disorder in a subject by administering a Janus Kinase/Signal Transducers and Activators of Transcription inhibitor. |
| FILED | Tuesday, July 19, 2022 |
| APPL NO | 17/868078 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 8/41 (20130101) A61K 31/52 (20130101) Specific Use of Cosmetics or Similar Toilet Preparations A61Q 7/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230043407 | Grattoni et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE METHODIST HOSPITAL SYSTEM (Houston, Texas) |
| ASSIGNEE(S) | THE METHODIST HOSPITAL SYSTEM (Houston, Texas) |
| INVENTOR(S) | Alessandro Grattoni (Houston, Texas); Xuewu Liu (Sugar Land, Texas); Mauro Ferrari (Houston, Texas) |
| ABSTRACT | Devices and methods for controlling molecular transport are disclosed herein. The devices include a membrane having a plurality of nanochannels extending therethrough. The membrane has an inner electrically conductive layer and an outer dielectric layer. The outer dielectric layer creates an insulative barrier between the electrically conductive layer and the contents of the nanochannels. At least one electrical contact region is positioned on a surface of the membrane. The electrical contact region exposes the electrically conductive layer of the membrane for electrical coupling to external electronics. When the membrane is at a first voltage, molecules flow through the nanochannels at a first release rate. When the membrane is at a second voltage, charge accumulation within the nanochannels modulates the flow of molecules through the nanochannels to a second release rate that is different than the first release rate. Methods of fabricating devices for controlling molecular transport are also disclosed herein. |
| FILED | Friday, January 15, 2021 |
| APPL NO | 17/758644 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/16804 (20130101) A61M 2205/0233 (20130101) A61M 2205/3317 (20130101) Microstructural Devices or Systems, e.g Micromechanical Devices B81B 1/004 (20130101) Original (OR) Class B81B 2201/054 (20130101) B81B 2203/04 (20130101) B81B 2203/0353 (20130101) Processes or Apparatus Specially Adapted for the Manufacture or Treatment of Microstructural Devices or Systems B81C 1/00087 (20130101) B81C 2201/0132 (20130101) B81C 2201/0133 (20130101) B81C 2201/0176 (20130101) B81C 2201/0178 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230043421 | Hickman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Hickman (Orlando, Florida); Kazi Tasneem (Orlando, Florida); Christopher Long (Oviedo, Florida) |
| ABSTRACT | Disclosed herein are microfluidic systems with recirculation of fluid and computer-implemented methods of calculating conditions within the microfluidic systems. The microfluidic systems include a computing device and a microfluidic device having first and second reservoirs, at least one chamber, and a fluid path connecting the first reservoir, the chamber, and the second reservoir. The methods for calculating conditions include receiving a first reservoir fluid volume, a second reservoir fluid volume, a first concentration, and a second concentration. The methods further include receiving a time-dependent imposed pressure difference between the first reservoir and the second reservoir, then determining a hydraulic pressure difference and an effective pressure difference. The effective pressure difference is used to account for reactions occurring within the microfluidic device and to determine the value of the condition within the microfluidic device. Methods of performing an experiment using a microfluidic device with recirculation are also disclosed herein. |
| FILED | Friday, September 09, 2022 |
| APPL NO | 17/941445 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5023 (20130101) B01L 3/5027 (20130101) Electric Digital Data Processing G06F 30/23 (20200101) Original (OR) Class G06F 2111/20 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230043677 | Kim et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Oregon State University (Corvallis, Oregon) |
| ASSIGNEE(S) | Oregon State University (Corvalis, Oregon) |
| INVENTOR(S) | Jeonghwan Kim (Corvallis, Oregon); Gaurav Sahay (Corvallis, Oregon) |
| ABSTRACT | Disclosed herein are embodiments of a nanoparticle composition suitable for delivering a therapeutic agent to a subject by nebulization. The nanoparticle comprises an ionizable lipid, cholesterol or a derivative thereof, a structural lipid, and a PEG lipid. The nanoparticle may partially or completely encapsulate a therapeutic agent, and may be nebulized for administration, such as by inhalation. In some embodiments, the therapeutic agent is mRNA. |
| FILED | Monday, July 25, 2022 |
| APPL NO | 17/872830 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0078 (20130101) A61K 9/1272 (20130101) Original (OR) Class A61K 31/7105 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230043806 | Thakur et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia); Wayne State University (Detroit, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Archana Thakur (Zion Crosseroads, None); Lawrence G. Lum (Charlottesville, None); Srividya Yarlagadda (Rochester, None) |
| ABSTRACT | Methods and compositions for treating cancer in a subject in need thereof. The method includes administering to the subject an effective amount of a composition comprising Tumor-Targeting Effectors (TITE) derived from a culture comprising a bispecific antibody armed activated T cell (BAT) and a cancer cell, to thereby treat cancer in the subject. |
| FILED | Friday, February 28, 2020 |
| APPL NO | 17/434692 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/13 (20130101) A61K 35/17 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2809 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230043813 | Fellmann |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christof Fellmann (San Francisco, California) |
| ABSTRACT | Described herein are compositions, kits and methods for shredding the genomes of selected cell types, for example, the genomes of selected cancer cell types. |
| FILED | Friday, October 02, 2020 |
| APPL NO | 17/765583 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/005 (20130101) Peptides C07K 2319/50 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2740/15043 (20130101) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230043964 | SIMONS et al. |
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| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael SIMONS (Hamden, Connecticut); Pei-Yu CHEN (East Haven, Connecticut) |
| ABSTRACT | In some aspects, the invention provides a method of treating atherosclerosis in a subject. The method comprises administering to the subject an agent that increases the activity or level of a let-7 miRNA or an agent that decreases activity or level of a TGFβ signaling polypeptide in an endothelial cell in the subject. In some embodiments, the subject is administered an additional agent comprising a therapeutically effective amount of rapamycin or any derivative thereof. In some embodiments, the agent is a let-7 miRNA. In some other aspects, the invention provides a pharmaceutical composition comprising a let-7 miRNA. In some embodiments, the let-7 miRNA is encapsulated in a nanoparticle formulated for selective delivery to an endothelial cell. |
| FILED | Friday, April 15, 2022 |
| APPL NO | 17/721666 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/51 (20130101) A61K 31/436 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 15/1138 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/141 (20130101) C12N 2320/32 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230044044 | Bornholdt et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Mapp Biopharmaceutical, Inc. (San Diego, California); Albert Einstein College of Medicine (Bronx, New York); Adimab, LLC (Lebanon, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zachary A. Bornholdt (Encinitas, California); Larry Zeitlin (San Diego, California); Kartik Chandran (Brooklyn, New York); Anna Wec (Lebanon, New Hampshire); Laura Walker (Norwich, Vermont) |
| ABSTRACT | Described herein are compositions and methods for the prevention and treatment of ebolavirus infection. In certain embodiments of the present invention, monoclonal antibodies substantially similar to those described herein, as well as affinity matured variants thereof, alone or in combination, provide therapeutic efficacy in a patient against multiple species of ebolavirus. |
| FILED | Friday, July 01, 2022 |
| APPL NO | 17/856774 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/57 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230044407 | FERIS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edmond J. FERIS (Philadelphia, Pennsylvania); Michael D. COLE (Hanover, New Hampshire) |
| ABSTRACT | Provided are methods and compositions for identifying inhibitors of an interaction between the oncogenic transcription factor MYC and its cofactor TRRAP. The methods involve both cell-based and in vitro approaches for probing an interaction between MYC and TRRAP and for identifying inhibitors of a MYC-TRRAP interaction. Also provided are compounds for use as inhibitors of an interaction between MYC and TRRAP, and methods for developing a cancer therapeutic from such compounds, including methods for derivatizing such inhibitors and for testing the inhibitors and derivatized inhibitors for an ability to treat cancer in a subject. The methods, compounds, and compositions provided herein can provide various advantages, such as a means to target the oncogenic transcription factor MYC in cancer. |
| FILED | Wednesday, December 02, 2020 |
| APPL NO | 17/781406 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/427 (20130101) Original (OR) Class A61K 31/501 (20130101) A61K 31/502 (20130101) A61K 31/517 (20130101) A61K 31/519 (20130101) A61K 31/4184 (20130101) A61K 31/4439 (20130101) A61K 31/4709 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5023 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230044467 | Seyedsayamdost et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| INVENTOR(S) | Mohammad R. Seyedsayamdost (Princeton, New Jersey); Vasiliki T. Chioti (Plainsboro, New Jersey); Katherine M. Davis (Decatur, Georgia); Kirklin L. McWhorter (Decatur, Georgia) |
| ABSTRACT | Bacterial infections evading the current antibiotic arsenal warrant new treatment options. The mainstay treatment for Clostridium difficile infections involves administration of the broad-spectrum antibiotic vancomycin, which also depletes the gut microbiome and its natural defenses. This leads to recurrent C. difficile infections in 20-30% of patients. Alternative treatment options are limited, triggering a perpetual cycle of relapse and recovery that may eventually lead to death. Keratinicyclin B represents a glycopeptide antibiotic chemotype with a mechanism of action that is selective for Clostridia. When combined, vancomycin (or other glycopeptide antibiotic) and keratinicyclin B interact synergistically to inhibit the growth of C. difficile at concentrations far lower than their respective minimal inhibitory concentrations. Such a combination therapy could allow for targeted colonization clearance at low antibiotic doses, thereby minimizing toxicity and reducing the likelihood of relapse. |
| FILED | Tuesday, July 26, 2022 |
| APPL NO | 17/873269 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/14 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 9/008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230044615 | Oeffinger et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Thomas Jefferson University (Philadelphia, Pennsylvania); Drexel University (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | Thomas Jefferson University (Philadelphia, Pennsylvania); Drexel University (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Brian Edward Oeffinger (Philadelphia, Pennsylvania); Margaret A. Wheatley (Media, Pennsylvania); Rawan Shraim (Philadelphia, Pennsylvania); Purva Vaidya (Flushing, New York); John Robert Eisenbrey (Wayne, Pennsylvania) |
| ABSTRACT | One aspect of the invention provides a method for freeze-drying surfactant-stabilized microbubbles. The method includes: preparing vials comprising a mixture comprising microbubbles; partially submerging the vials in a chilled water bath, wherein the water bath has a sub-freezing temperature; placing the vials on a cooled shelf of a lyophilizer; freeze-drying the vials in the lyophilizer; and capping the freeze-dried vials. Another aspect of the invention provides a method for annealing surfactant-stabilized microbubbles. The method includes: preparing vials comprising a mixture comprising microbubbles; passing the vials in and out of liquid nitrogen (LN2) until the mixture is frozen; holding the vials at −20° C.; placing the vials on a cooled shelf of a lyophilizer; freeze-drying the vials in the lyophilizer; and capping the freeze-dried vials. |
| FILED | Thursday, June 30, 2022 |
| APPL NO | 17/810157 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/223 (20130101) Original (OR) Class A61K 49/227 (20130101) A61K 2800/84 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230044670 | Boden et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott D. Boden (Atlanta, Georgia); Sreedhara Sangadala (Atlanta, Georgia) |
| ABSTRACT | The disclosure relates to compounds and compositions for forming bone and methods related thereto. In one embodiment, the disclosure relates to a composition comprising a compound disclosed herein, such as 2,4-diamino-1,3,5-triazine derivatives or salts thereof, for use in bone growth processes. In a typical embodiment, a bone graft composition is implanted in a subject at a site of desired bone growth or enhancement. |
| FILED | Wednesday, September 28, 2022 |
| APPL NO | 17/936184 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/53 (20130101) Original (OR) Class A61K 38/1875 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/54 (20130101) A61L 2300/412 (20130101) A61L 2430/02 (20130101) Heterocyclic Compounds C07D 251/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230044706 | Frisken et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sarah FRISKEN (Boston, Massachusetts); Clement MIRABEL (Boston, Massachusetts); Parikshit JUVEKAR (Boston, Massachusetts); Takahisa KATO (Irvine, California); Alexandra J. GOLBY (Boston, Massachusetts); Garth R. COSGROVE (Boston, Massachusetts); Thomas NOH (Boston, Massachusetts); Canon U.S.A., Inc. (Melville, New York); The Brigham and Women's Hospital Incorporated (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sarah Frisken (Cambridge, Massachusetts); Clement Mirabel (Brookline, Massachusetts); Parikshit Juvekar (Brookline, Massachusetts); Takahisa Kato (Brookline, Massachusetts); Alexandra J. Golby (Jamaica Plain, Massachusetts); Garth R. Cosgrove (Boston, Massachusetts); Thomas Noh (Boston, Massachusetts) |
| ABSTRACT | Exemplary methods and systems that provide a curved path trajectory that can be used with a bendable medical device. The curved pathway can comprise straight and curved concatenated arc segments. The methods and systems can provide planning, visualizing and treatment of, for example, temporal lobe epilepsy (TLE) using laser interstitial thermal therapy (LITT) or tumors using ablation therapy. With curved pathway, the physician can create plan for intervention to avoid critical structure and to cover more target volume for treatment/diagnosis than straight pathway |
| FILED | Friday, January 08, 2021 |
| APPL NO | 17/791168 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 34/10 (20160201) Original (OR) Class A61B 34/20 (20160201) A61B 2034/105 (20160201) A61B 2034/107 (20160201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230044825 | Lasker et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Chan Zuckerberg Biohub, Inc. (San Francisco, California); The Board of Trustees of the Leland Stanford Junior Univesity (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Keren Lasker (Palo Alto, California); Steven Boeynaems (Stanford, California); Aaron David Gitler (Foster City, California); Lucy Shapiro (Palo Alto, California) |
| ABSTRACT | Proteins and fusion proteins for forming merbraneless droplets in cells are provided. Described herein, is the development of a protein, named PopTag, that drives phase separation when it is part of a chimeric fusion protein. PopTag is engineered from the PopZ protein, found in a-proteobacteria (including Caulobacter crescentus). Despite PopZ being exclusively found in this clade of bacteria, the PopTag can drive protein phase separation in other prokaryotes (e.g., E. coli) and eukaryotes (e.g., human cells). |
| FILED | Friday, December 04, 2020 |
| APPL NO | 17/782366 |
| CURRENT CPC | Peptides C07K 14/195 (20130101) Original (OR) Class C07K 2317/622 (20130101) C07K 2319/735 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/62 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230045112 | Srivenugopal et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Texas Tech University System (Lubbock, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kalkunte S. Srivenugopal (Amarillo, Texas); Ameya M. Paranjpe (Amarillo, Texas) |
| ABSTRACT | The present disclosure provides a compositions and methods of inhibiting O6-methylguanine DNA methyltransferase in human tumor cells by providing an effective amount of an agent that directly or indirectly inhibits the O6-methylguanine DNA methyltransferase in a pharmaceutically acceptable carrier, wherein the amount is effective to potentiate an anti-tumor activity of one or more alkylating agents, platinum drugs, or antimetabolites, wherein tumor cells are triggered into programmed cell death. |
| FILED | Thursday, September 29, 2022 |
| APPL NO | 17/956249 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/4833 (20130101) A61K 31/194 (20130101) A61K 31/404 (20130101) A61K 33/34 (20130101) Original (OR) Class A61K 47/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230045142 | Roden et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Richard B.S. Roden (Baltimore, Maryland); Ravi K. Anchoori (Baltimore, Maryland) |
| ABSTRACT | Compounds of formula (I), (II), and (III) having the structure shown below are presented: wherein R-R6 are defined herein. These molecules work as proteasome inhibitors and bind to the RPN13 subunit of the 19S regulatory particle, and can be used in methods of treating a condition or a disease, such as cancer, in a mammal |
| FILED | Friday, December 04, 2020 |
| APPL NO | 17/781507 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 211/86 (20130101) Original (OR) Class C07D 471/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230045199 | BLOBEL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE CHILDREN'S HOSPITAL OF PHILADELPHIA (Philadelphia, Pennsylvania); THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gerd BLOBEL (Bala Cynwyd, Pennsylvania); Scott PESLAK (King of Prussia, Pennsylvania); Junwei SHI (Philadelphia, Pennsylvania) |
| ABSTRACT | Methods and compositions for producing fetal hemoglobin and treating a hemoglobinopathy or thalassemia are disclosed. |
| FILED | Wednesday, December 23, 2020 |
| APPL NO | 17/786147 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/454 (20130101) A61K 31/713 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/06 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2320/31 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230045284 | Satchell et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karla J.F. Satchell (Evanston, Illinois); Irena Antic (Chicago, Illinois); Marco Biancucci (Chicago, Illinois) |
| ABSTRACT | Disclosed are bacterial toxins and uses thereof as specific proteases for Ras sarcoma oncoproteins (Ras proteins). The bacterial toxins may be modified for use as pharmaceutical agents for treating Ras-dependent diseases and disorders including cell proliferation diseases and disorders such as cancer. |
| FILED | Tuesday, May 17, 2022 |
| APPL NO | 17/746952 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/48 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/52 (20130101) Original (OR) Class Enzymes C12Y 304/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230045325 | Racioppi |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Luigi Racioppi (Durham, North Carolina) |
| ABSTRACT | Described is a method for promoting regeneration of hematopoietic stem and progenitor cells in a subject in need thereof. The method comprises administering to the subject a composition comprising a CaMKK2 inhibitor. The CaMKK2 inhibitor may be a small molecule inhibitor, such as STO-609. |
| FILED | Monday, August 01, 2022 |
| APPL NO | 17/878594 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/437 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230045375 | Cheng et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trustees of Boston University (Boston, Massachusetts) |
| ASSIGNEE(S) | Trustees of Boston University (Boston, Massachusetts) |
| INVENTOR(S) | Ji-Xin Cheng (Newton, Massachusetts); Lu Lan (Allston, Massachusetts); Jiaze Yin (Waltham, Massachusetts) |
| ABSTRACT | Systems and methods are provided for performing photothermal dynamic imaging. An exemplary method includes: scanning a sample to produce a plurality of raw photothermal dynamic signals; receiving the raw photothermal dynamic signals of the sample; generating a plurality of second signals by matched filtering the raw photothermal dynamic signals to reject non-modulated noise; and performing an inverse operation on the second signals to retrieve at least one thermodynamic signal in a temporal domain. |
| FILED | Friday, August 05, 2022 |
| APPL NO | 17/881996 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/35 (20130101) G01N 21/47 (20130101) G01N 21/171 (20130101) Original (OR) Class G01N 2021/3595 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230045390 | Kappe et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Seattle Children's Hospital dba Seattle Children's Research Institute (Seattle, Washington) |
| ASSIGNEE(S) | Seattle Children's Hospital dba Seattle Children's Research Institute (Seattle, Washington) |
| INVENTOR(S) | Stefan H.I. Kappe (Seattle, Washington); Noah Sather (Seattle, Washington); Gigliola Zanghi (Seattle, Washington); Erika L. Flannery (Oakland, California); Hemando Del Portillo (Barcelona, Spain); Melisa Gualdron Lopez (Barcelona, Spain); Carmen Fernández-Becerra (Barcelona, Spain) |
| ABSTRACT | The present disclosure provides a method of detecting the presence of a hypnozoite stage of Plasmodium vivax in a liver cell. In addition, the present disclosure provides compositions and methods of detecting the presence of a latent Plasmodium vivax infection in a subject and for treating the subject detected to be infected. |
| FILED | Wednesday, July 06, 2022 |
| APPL NO | 17/810982 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Peptides C07K 14/445 (20130101) C07K 16/205 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6848 (20130101) G01N 33/56905 (20130101) Original (OR) Class G01N 2333/445 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230045462 | Rosbash et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Brandeis University (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Rosbash (Waltham, Massachusetts); Aoife McMahon (Waltham, Massachusetts); Weijin Xu (Waltham, Massachusetts); Hua Jin (Waltham, Massachusetts) |
| ABSTRACT | The present invention features fusion polypeptides comprising an RNA binding polypeptide operationally linked to an RNA modifying enzyme (e.g., adenosine deaminase, cytidine deaminase), and methods of use therefore. |
| FILED | Friday, May 13, 2022 |
| APPL NO | 17/743859 |
| CURRENT CPC | Peptides C07K 14/47 (20130101) C07K 2319/20 (20130101) C07K 2319/85 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 9/78 (20130101) Original (OR) Class C12N 15/86 (20130101) C12N 2750/14122 (20130101) Enzymes C12Y 305/04004 (20130101) C12Y 305/04005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230045522 | FLOYD |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elizabeth FLOYD (Baton Rouge, Louisiana) |
| ABSTRACT | This invention is directed to compositions and methods for modulating glucose homeostasis. |
| FILED | Thursday, December 03, 2020 |
| APPL NO | 17/782949 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/12 (20130101) A61K 36/282 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230045621 | Unutmaz |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Jackson Laboratory (Bar Harbor, Maine) |
| ASSIGNEE(S) | The Jackson Laboratory (Bar Harbor, Maine) |
| INVENTOR(S) | Derya Unutmaz (Burlington, Connecticut) |
| ABSTRACT | A method and system for developing a predictive model for diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) in a human are disclosed. The method comprises receiving immune system data for each member of a population comprising healthy humans and humans with ME/CFS; extracting a set of features from the immune system data; and training a machine learning algorithm using the set of features to classify a human as healthy or having ME/CFS to obtain a predictive model. The system comprises a processor; and a memory storing computer executable instructions, which when executed by the processor cause the processor to perform operations of said method. |
| FILED | Friday, December 18, 2020 |
| APPL NO | 17/788486 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 7/005 (20130101) G06N 20/20 (20190101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 40/20 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20230037458 | WON |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Temple University - Of The Commonwealth System Of Higher Education (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | Temple University - Of The Commonwealth System Of Higher EducationB (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Chang-Hee WON (Maple Glen, Pennsylvania) |
| ABSTRACT | A mobile-platform imaging device uses compression of the target region to generate an image of an object. A tactile sensor has an optical waveguide with a flexible, transparent first layer. Light is directed into the waveguide. Light is scattered out of the first layer when the first layer is deformed. The first layer is deformed by the tactile sensor being pressed against the object. A force sensor detects a force pressing the tactile sensor against the object and outputs corresponding force information. A first communication unit receives the force information from the force sensor. A receptacle holds a mobile device with a second communication unit and an imager that can generate image information using light scattered out of the first layer. The first communication unit communicates with the second communication unit and the mobile device communicates with an external network. |
| FILED | Friday, September 30, 2022 |
| APPL NO | 17/957178 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0053 (20130101) Original (OR) Class A61B 5/0059 (20130101) A61B 5/444 (20130101) A61B 5/6843 (20130101) A61B 5/6898 (20130101) A61B 5/7267 (20130101) A61B 5/7275 (20130101) A61B 2090/306 (20160201) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 3/08 (20130101) G01N 19/00 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Telephonic Communication H04M 1/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230037596 | Kang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yuan Jochen Kang (New York, New York); Salvatore Stolfo (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yuan Jochen Kang (New York, New York); Salvatore Stolfo (New York, New York) |
| ABSTRACT | Mechanisms for defending a computing system from attack, comprising: maintaining a round counter that tracks a round number for a local host; determining a location in a graph for each of a plurality of hosts including the local host; determining monitor hosts of the plurality of hosts that are monitoring the local host; determining monitoree hosts of the plurality of hosts that are being monitored by the local host; sending a message to each of the monitor hosts identifying a value of the round counter; forwarding a first set of heartbeat messages from previous monitoree hosts to the monitor hosts; attempting to receive messages from the monitoree hosts; determining whether any messages were not received from the monitoree hosts; and in response to determining that one or more messages were not received from the monitoree hosts, generating an alert. |
| FILED | Friday, March 18, 2022 |
| APPL NO | 17/698751 |
| CURRENT CPC | Electric Digital Data Processing G06F 7/582 (20130101) G06F 9/542 (20130101) G06F 21/54 (20130101) G06F 21/602 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/1416 (20130101) H04L 63/1425 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230037820 | Dale et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Kenny Dale (PC Beach, Florida); Enrique Garza (Destin, Florida); Noah Roberts (Bloomington, Indiana); Shawn Kelstrup (Tacoma, Washington); Jesse Chen (Bloomington, Indiana); Gerrot Jones (Bloomington, Indiana); Lee Zaloudek (Laporte, Colorado); Darrel Yung (Bloomington, Indiana) |
| ABSTRACT | A portable and rapid communication or signaling device and related methods for operating or using tactile identification structures as well as coupling/mounting/release structures which enable rapid identification of similarly shaped objects and rapid deployment or use with safety or other equipment. Various embodiments enable using a common mounting location of these similarly shaped objects that each have different spectrum or color emissive capabilities that improve operator selection within conditions further impairing identification and employment and increase operator cognitive load. |
| FILED | Tuesday, August 09, 2022 |
| APPL NO | 17/884016 |
| CURRENT CPC | Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 6/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230037882 | Spivey et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Spivey (Durham, North Carolina); Kai Hedek (Durham, North Carolina); Ismail Inlek (Durham, North Carolina); Jungsang Kim (Durham, North Carolina); Zhubing Jia (Durham, North Carolina) |
| ABSTRACT | Technologies for an optomechanical system include an intermediate plate having a top surface with multiple tapped holes arranged in a grid. A pair of dowel pin holes surround each tapped hole in a linear pattern. Multiple optical blocks are coupled to the intermediate plate using dowel pins positioned in the dowel pin holes and corresponding dowel pin holes defined in the bottom surface of the optical block. Each optical block includes multiple optical elements coupled to the top surface of the optical block with dowel pins. A cryostat may be coupled to the intermediate plate. A cryo-package assembly is mounted inside a cryo chamber of the cryostat. The cryo-package assembly includes a cryo device such as an ion trap covered by a machined copper lid. The lid includes a meandering passageway to allow for differential pumping in order to achieve ultra-high vacuum within the cryo-package assembly. |
| FILED | Monday, August 08, 2022 |
| APPL NO | 17/883062 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 7/003 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230037962 | Markvicka et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric Markvicka (Brush, Colorado); Tom Frederick (Lincoln, Nebraska); Jack Mondry (Edina, Minnesota); Joe Bartels (Pittsburgh, Pennsylvania); Shane Farritor (Lincoln, Nebraska) |
| ABSTRACT | The various robotic medical devices include robotic devices that are disposed within a body cavity and positioned using a support component disposed through an orifice or opening in the body cavity. Additional embodiments relate to devices having arms coupled to a device body wherein the device has a minimal profile such that the device can be easily inserted through smaller incisions in comparison to other devices without such a small profile. Further embodiments relate to methods of operating the above devices. |
| FILED | Tuesday, October 11, 2022 |
| APPL NO | 17/963438 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 34/30 (20160201) Original (OR) Class A61B 90/361 (20160201) A61B 2034/302 (20160201) Technical Subjects Covered by Former US Classification Y10T 74/20317 (20150115) Y10T 74/20329 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230038135 | Gowanlock et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of Northern Arizona University (Flagstaff, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Gowanlock (Flagstaff, Arizona); Bertrand F. Cambou (Flagstaff, Arizona); Kaitlyn Lee (Flagstaff, Arizona); Christopher R. Philabaum (Flagstaff, Arizona) |
| ABSTRACT | Systems and methods for cryptographic key generation at a client and server are disclosed. The client has an array of PUF devices, and the server has an image that PUF. The server sends the client addresses of PUF devices to be measured, and retrieves previously stored responses corresponding to those addresses from its database. The client measures responses at the addresses. Each device hashes the resulting responses, and the server compares the hash received from the client to its own. If the hashes to not match, the server searches for a matching hash be perturbing the measured response bit stream until a match is achieved. The perturbed response bitstream, and the measured response at the client are then salted, and used for key generation. |
| FILED | Friday, July 22, 2022 |
| APPL NO | 17/871850 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0643 (20130101) H04L 9/0866 (20130101) H04L 9/3278 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230038288 | Pale |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Andrew M. Pale (King George, Virginia) |
| ASSIGNEE(S) | United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Andrew M. Pale (King George, Virginia) |
| ABSTRACT | A gripping device is provided for grasping an object. The device includes a frame, an axial threaded screw, an actuator, an armature, a plurality of links, and a plurality of arms. The frame has proximal and distant ends to hold the screw. The actuator connects to the screw at the proximal end. The armature threads onto the screw. The links radially extend from the armature. Each link terminates in a ball tip. Each arm includes a lever bounded by a proximal hinge and a distal claw. The lever contains a plate to slide therealong. The plate has a socket that receives the ball tip. The hinge pivotably connects to the proximal end of the frame. The actuator turns the screw, thereby translating the armature aft towards the distal end of the frame. The armature carries each link to pull its ball tip aft, thereby causing each arm to radially contract its claw around the object. |
| FILED | Monday, August 09, 2021 |
| APPL NO | 17/396856 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 15/10 (20130101) Original (OR) Class B25J 15/022 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230038480 | STEPHENS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland); THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (Washington, District of Columbia) |
| ASSIGNEE(S) | UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland); THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (Washington, District of Columbia) |
| INVENTOR(S) | Kristina STEPHENS (Takoma Park, Maryland); William E. BENTLEY (Annapolis, Maryland); Jessica Lynn LIBA (Drexel Hill, Pennsylvania); Ryan MCKAY (Peekskill, New York); Micaela EVERITT (Washington, District of Columbia) |
| ABSTRACT | The presently disclosure relates to a system and method for bioelectronic communications. In certain embodiments the system comprises a bacterial cell or cells that comprise a genetic system for high-efficiency over-expression and secretion of recombinant proteins in bacteria. In certain embodiments, the system and method operate in a “pump-then-burst release” fashion to rapidly achieve high yields extracellularly. In certain embodiments, the system and method include quorum sensing-derived regulation, which may enable auto-induction of a protein's expression and secretion. |
| FILED | Friday, July 08, 2022 |
| APPL NO | 17/861150 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/19 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 5/10 (20130101) C12N 2500/02 (20130101) C12N 2510/00 (20130101) C12N 2523/00 (20130101) C12N 2529/00 (20130101) C12N 2533/10 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230038745 | Tassev |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vladimir Tassev (Beavercreek, Ohio) |
| ABSTRACT | A method of performing heteroepitaxy comprises exposing a substrate to a carrier gas, a first precursor gas, a Group II/III element, and a second precursor gas, to form a heteroepitaxial growth of one of GaAs, AlAs, InAs, GaP, InP, ZnSe, GaSe, CdSe, InSe, ZnTe, CdTe, GaTe, HgTe, GaSb, InSb, AlSb, CdS, GaN, and AlN on the substrate; wherein the substrate comprises one of GaAs, AlAs, InAs, GaP, InP, ZnSe, GaSe, CdSe, InSe, ZnTe, CdTe, GaTe, HgTe, GaSb, InSb, AlSb, CdS, GaN, and AlN; wherein the carrier gas is Hz, wherein the first precursor is HCl, the Group II/III element comprises at least one of Zn, Cd, Hg, Al, Ga, and In; and wherein the second precursor is one of AsH3 (arsine), PH3 (phosphine), H2Se (hydrogen selenide), H2Te (hydrogen telluride), SbH3 (hydrogen antimonide), H2S (hydrogen sulfide), and NH3 (ammonia). The process may be an HVPE (hydride vapor phase epitaxy) process. |
| FILED | Tuesday, October 04, 2022 |
| APPL NO | 17/937840 |
| CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 25/04 (20130101) Original (OR) Class C30B 25/18 (20130101) C30B 29/42 (20130101) C30B 29/44 (20130101) C30B 29/48 (20130101) C30B 29/406 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/3556 (20130101) G02F 1/3558 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0254 (20130101) H01L 21/0262 (20130101) H01L 21/02293 (20130101) H01L 21/02389 (20130101) H01L 21/02392 (20130101) H01L 21/02395 (20130101) H01L 21/02398 (20130101) H01L 21/02458 (20130101) H01L 21/02461 (20130101) H01L 21/02463 (20130101) H01L 21/02466 (20130101) H01L 21/02505 (20130101) H01L 21/02543 (20130101) H01L 21/02546 (20130101) H01L 21/02549 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230039196 | Lobo |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Arthur P. Lobo (Fishers, Indiana) |
| ABSTRACT | Provided is a detection and classification system and method for small unmanned aircraft systems (sUAS). The system and method detect and classify multiple simultaneous heterogeneous RC transmitters/sUAS downlinks from the RF signature using Object Detection Deep Convolutional Neural Networks (DCNNs). The method further utilizes not only passive RF, but may also utilize Electro Optic/Infrared (EO/IR), radar and acoustic sensors as well, with a fusion of the individual sensor classifications. Detection and classification with Identification Friend or Foe (IFF) of individual sUAS in a swarm, multi-modal approach for high confidence classification, decision, and implementation on a low C-SWaP (cost, size, weight and power) NVIDIA Jetson TX2 embedded AI platform is achieved. |
| FILED | Tuesday, August 09, 2022 |
| APPL NO | 17/884377 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 39/024 (20130101) B64C 2201/143 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/0022 (20130101) G05D 1/104 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 5/042 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230040237 | CHEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Intelligent Fusion Technology, Inc. (Germantown, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hua-mei CHEN (Germantown, Maryland); Bora SUL (Germantown, Maryland); Genshe CHEN (Germantown, Maryland); Erik BLASCH (Arlington, Virginia); Khanh PHAM (Kirtland AFB, New Mexico) |
| ABSTRACT | A method for detecting fake images includes: obtaining an image for authentication, and hand-crafting a multi-attribute classifier to determine whether the image is authentic. Hand-crafting the multi-attribute classifier includes fusing at least an image classifier, an image spectrum classifier, a co-occurrence matrix classifier, and a one-dimensional (1D) power spectrum density (PSD) classifier. The multi-attribute classifier is trained by pre-processing training images to generate an attribute-specific training dataset to train each of the image classifier, the image spectrum classifier, the co-occurrence matrix classifier, and the 1D PSD classifier. |
| FILED | Friday, July 29, 2022 |
| APPL NO | 17/876908 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/0002 (20130101) Original (OR) Class G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) Image or Video Recognition or Understanding G06V 10/82 (20220101) G06V 10/811 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230040289 | Sels et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dries W. H. Sels (Allston, Massachusetts); Eugene A. Demler (Cambridge, Massachusetts) |
| ABSTRACT | Quantum generative models for sampling many-body spectral functions are provided. Quantum approximate Bayesian computation is provided for NMR model inference. |
| FILED | Thursday, April 21, 2022 |
| APPL NO | 17/726057 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/60 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230040495 | CHU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF HOUSTON SYSTEM (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ching-Wu CHU (Houston, Texas); Liangzi DENG (Pearland, Texas); Zheng WU (Missouri City, Texas) |
| ABSTRACT | A pressure-quench techniques at chosen pressures and temperatures to lock in the high-pressure-induced superconducting phase and/or non-superconducting phase in high-temperature superconductors (HTS) and room-temperature superconductors (RTS) at ambient pressure are disclosed. The techniques remove the formidable obstacle to the ubiquitous practical application of HTS and RTS. The technique successfully retain the high-pressure-induced/-enhanced high Tc and/or non-superconducting properties of HTS or RTS. |
| FILED | Monday, August 08, 2022 |
| APPL NO | 17/883534 |
| CURRENT CPC | Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 6/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230040818 | Mirkin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chad A. Mirkin (Wilmette, Illinois); David A. Walker (Evanston, Illinois); James L. Hedrick, III (Evanston, Illinois) |
| ABSTRACT | Methods and apparatus comprising a dewetting phase and a polymerization liquid that are immiscible, and can be used for the formation of three-dimensional objects, wherein the method does not require a dead zone. Additionally, methods and apparatus that employ an optically transparent cooling apparatus to mitigate heat generated during the fabrication process, and the use of a mobile phase to provide a shearing interface to reduce interfacial adhesive forces. |
| FILED | Tuesday, September 06, 2022 |
| APPL NO | 17/903260 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/129 (20170801) Original (OR) Class B29C 64/245 (20170801) B29C 64/264 (20170801) B29C 67/00 (20130101) B29C 67/24 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230040882 | Seeley et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Eric Seeley (Seebeck, Washington); Logan Harris (Silverdale, Washington) |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Keyport, Washington) |
| INVENTOR(S) | Eric Seeley (Seebeck, Washington); Logan Harris (Silverdale, Washington) |
| ABSTRACT | A field configurable autonomous vehicle includes modular elements and attachable components. The vehicle can be assembled from these modular elements and components to meet desired mission and performance characteristics without the need to purchase specially designed vehicles for each mission. The vehicle can include a modular propulsion system with magnetic drive. |
| FILED | Friday, September 30, 2022 |
| APPL NO | 17/956849 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Vehicles for Use Both on Rail and on Road; Amphibious or Like Vehicles; Convertible Vehicles B60F 5/00 (20130101) Motor Vehicles; Trailers B62D 57/04 (20130101) Offensive or Defensive Arrangements on Vessels; Mine-laying; Mine-sweeping; Submarines; Aircraft Carriers B63G 8/001 (20130101) B63G 8/08 (20130101) Original (OR) Class Dynamo-electric Machines H02K 21/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230041208 | Tsedev et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Uyanga Tsedev (Somerville, Massachusetts); Angela M. Belcher (Lexington, Massachusetts) |
| ABSTRACT | An engineered phage-derived particle (PDP) for expressing a transgene in a target cell transduced with a bacteriophage, the PDP includes (i) less than about 500 bp of DNA from the bacteriophage genome, (ii) an ITR-flanked therapeutic gene up to 20 kb, (iii) an endosomal escape sequence, (iv) a nuclear localization sequence, and (v) a cell-specific targeting moiety. The PDP may escape lysosomal degradation, traffic across the nuclear envelope and expressed a therapeutic gene in a mammalian cell. |
| FILED | Friday, May 06, 2022 |
| APPL NO | 17/738647 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/76 (20130101) Original (OR) Class A61K 38/00 (20130101) A61K 47/6901 (20170801) A61K 48/005 (20130101) A61K 49/0097 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/005 (20130101) C07K 2319/09 (20130101) C07K 2319/33 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/105 (20210501) C12N 7/00 (20130101) C12N 2795/14122 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230041362 | Brewer |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tony M. Brewer (Plano, Texas) |
| ABSTRACT | A memory controller circuit is disclosed which is coupleable to a first memory circuit, such as DRAM, and includes: a first memory control circuit to read from or write to the first memory circuit; a second memory circuit, such as SRAM; a second memory control circuit adapted to read from the second memory circuit in response to a read request when the requested data is stored in the second memory circuit, and otherwise to transfer the read request to the first memory control circuit; predetermined atomic operations circuitry; and programmable atomic operations circuitry adapted to perform at least one programmable atomic operation. The second memory control circuit also transfers a received programmable atomic operation request to the programmable atomic operations circuitry and sets a hazard bit for a cache line of the second memory circuit. |
| FILED | Sunday, October 02, 2022 |
| APPL NO | 17/958404 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/0604 (20130101) G06F 3/0659 (20130101) Original (OR) Class G06F 3/0683 (20130101) G06F 12/0875 (20130101) G06F 2212/452 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230041364 | McCreary et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Figure, Inc. (Lorton, Virginia) |
| ASSIGNEE(S) | Figure, Inc. (Lorton, Virginia) |
| INVENTOR(S) | Leonard McCreary (Lorton, Virginia); Chris Holtzclaw (Lorton, Virginia); Jonathon McDaniels (Lorton, Virginia) |
| ABSTRACT | Disclosed is a noise suppressor for use inside a nozzle and adjacent a nozzle liner. The suppressor can include an inlet with a cross-sectional area larger than that of the nozzle liner outlet. The suppressor can also have an entrance length with a diverging cross-sectional area, and an exit length extending from the entrance length. By incorporating this geometry, the noise suppressor reduces noise and improves performance of the apparatus in which the suppressor is used. |
| FILED | Monday, October 10, 2022 |
| APPL NO | 17/962646 |
| CURRENT CPC | Spraying Apparatus; Atomising Apparatus; Nozzles B05B 1/002 (20180801) Original (OR) Class Sound-producing Devices; Methods or Devices for Protecting Against, or for Damping, Noise or Other Acoustic Waves in General; Acoustics Not Otherwise Provided for G10K 11/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230041431 | Poon et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| INVENTOR(S) | Joseph Poon (Charlottesville, Virginia); Jie Qi (Charlottesville, Virginia) |
| ABSTRACT | Embodiments relate to a system for predicting thermodynamic phase of a material. The system includes a phase diagram image scanning processing module configured to scan a binary phase diagram for each material to be used as a component of a high-entropy alloy (HEA). The system includes a feature computation processing module configured to generate a primary feature and an adaptive feature. The primary feature is representative of a probability that the HEA will exhibit a solid solution phase and/or an intermetallic phase. The adaptive feature is representative of a factor favoring formation of a desired intermetallic HEA phase. The system includes a prediction module configured to encode the primary feature and/or the adaptive feature with thermodynamic data associated with formation of HEA alloy phases to provide an output representation of the HEA alloy phases for a material under analysis. |
| FILED | Tuesday, July 20, 2021 |
| APPL NO | 17/380549 |
| CURRENT CPC | Alloys C22C 30/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 25/02 (20130101) Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 20/30 (20190201) Original (OR) Class G16C 20/70 (20190201) G16C 60/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230041509 | Behandish et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Palo Alto Research Center Incorporated (Palo Alto, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Morad Behandish (Mountain View, California); Saigopal Nelaturi (Mountain View, California) |
| ABSTRACT | Two or more computational services are defined that each represent a respective different manufacturing capability used to partially create a target part model. A common space shared among the computational services is defined to reference the target part model and manufacturing primitives corresponding to each capability. The computational services are queried to construct a logical representation of the planning space based on intersections among the primitives. One or more process plans are formed using the different manufacturing capabilities to manufacture the part. |
| FILED | Monday, August 09, 2021 |
| APPL NO | 17/397499 |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/4183 (20130101) G05B 19/4188 (20130101) Original (OR) Class G05B 19/41885 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230041941 | FAROKHI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Kansas (Lawrence, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Saeed FAROKHI (San Diego, California); Ray TAGHAVI (Lawrence, Kansas); Zhi WANG (Lawrence, Kansas); Huixuan WU (Lawrence, Kansas); Zhongquan ZHENG (Logan, Utah) |
| ABSTRACT | A method of reducing noise from a high-speed, including supersonic, jet, the method includes providing the high-speed or supersonic jet in a longitudinal flow direction; and inducing a rotation of a swirl layer of the high-speed or supersonic jet around a longitudinal direction of the jet and on the jet boundary so as to promote mixing of the high-speed or supersonic jet with surrounding air. |
| FILED | Thursday, December 31, 2020 |
| APPL NO | 17/790599 |
| CURRENT CPC | Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 33/06 (20130101) Gas-flow Silencers or Exhaust Apparatus for Machines or Engines in General; Gas-flow Silencers or Exhaust Apparatus for Internal Combustion Engines F01N 1/14 (20130101) Jet-propulsion Plants F02K 1/46 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/323 (20130101) F05D 2260/963 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230042042 | Schafmeister et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Temple University-Of The Commonwealth System of Higher Education (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christian Schafmeister (Philadelphia, Pennsylvania); Justin Northrup (Philadelphia, Pennsylvania) |
| ABSTRACT | This invention provides unnatural amino acids as well as amino acid sequences, foldamers, macrocycles, and formulations comprising said unnatural amino acids. In one aspect of the invention, the unnatural amino acids or the formulation thereof are used to mimic natural amino acids or the formulations thereof in a subject in need thereof. |
| FILED | Thursday, December 17, 2020 |
| APPL NO | 17/785184 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4166 (20130101) Heterocyclic Compounds C07D 487/10 (20130101) Original (OR) Class C07D 487/20 (20130101) C07D 487/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230042055 | Stephenson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark M. Stephenson (New Carlisle, Ohio); Patrick Reber (Dayton, Ohio); Patrick J. Sweeney (Beavercreek, Ohio); Scott Graham (Beavercreek, Ohio) |
| ABSTRACT | An active attestation apparatus verifies at runtime the integrity of untrusted machine code of an embedded system residing in a memory device while it is being run/used with while slowing the processing time less than other methods. The apparatus uses an integrated circuit chip containing a microcontroller and a reprogrammable logic device, such as a field programmable gate array (FPGA), to implement software attestation at runtime and in less time than is typically possible with comparable attestation approaches, while not requiring any halt of the processor in the microcontroller. The reprogrammable logic device includes functionality to load an encrypted version of its configuration and operating code, perform a checksum computation, and communicate with a verifier. The checksum algorithm is preferably time optimized to execute computations in the reprogrammable logic device in the minimum possible time. |
| FILED | Thursday, October 20, 2022 |
| APPL NO | 17/969877 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/4401 (20130101) G06F 21/64 (20130101) G06F 21/76 (20130101) G06F 21/572 (20130101) Original (OR) Class G06F 2221/033 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/088 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230042222 | Brewer |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tony M. Brewer (Plano, Texas) |
| ABSTRACT | A representative system, apparatus, method and protocol are disclosed for data communication between chiplets or SOCs on a common interposer. A representative system comprises: an interposer; a first integrated circuit arranged on the interposer, the first integrated circuit comprising a first common protocol interface circuit; a communication link coupled to the first common protocol interface circuit; and a second integrated circuit arranged on the interposer, the second integrated circuit comprising a second common protocol interface circuit coupled to the communication link to form a serial protocol interface between the first common protocol interface circuit and the second common protocol interface circuit. Serial data and control packets and parallel data and control packets having specified, ordered fields are also disclosed. |
| FILED | Saturday, October 01, 2022 |
| APPL NO | 17/958343 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/394 (20200101) Original (OR) Class Static Stores G11C 7/1045 (20130101) G11C 11/409 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/40 (20220501) H04L 69/12 (20130101) H04L 69/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230042689 | Tassev |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vladimir Tassev (Beavercreek, Ohio) |
| ABSTRACT | A method of performing heteroepitaxy comprises exposing a substrate to a carrier gas, a first precursor gas, a Group II/III element, and a second precursor gas, to form a heteroepitaxial growth of one of GaAs, AlAs, InAs, GaP, InP, ZnSe, GaSe, CdSe, InSe, ZnTe, CdTe, GaTe, HgTe, GaSb, InSb, AlSb, CdS, GaN, and AlN on the substrate; wherein the substrate comprises one of GaAs, AlAs, InAs, GaP, InP, ZnSe, GaSe, CdSe, InSe, ZnTe, CdTe, GaTe, HgTe, GaSb, InSb, AlSb, CdS, GaN, and AlN; wherein the carrier gas is Hz, wherein the first precursor is HCl, the Group II/III element comprises at least one of Zn, Cd, Hg, Al, Ga, and In; and wherein the second precursor is one of AsH3 (arsine), PH3 (phosphine), H2Se (hydrogen selenide), HzTe (hydrogen telluride), SbH3 (hydrogen antimonide), H2S (hydrogen sulfide), and NH3 (ammonia). The process may be an HVPE (hydride vapor phase epitaxy) process. |
| FILED | Tuesday, October 04, 2022 |
| APPL NO | 17/937862 |
| CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 25/04 (20130101) Original (OR) Class C30B 25/18 (20130101) C30B 29/42 (20130101) C30B 29/44 (20130101) C30B 29/48 (20130101) C30B 29/406 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/3556 (20130101) G02F 1/3558 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0254 (20130101) H01L 21/0262 (20130101) H01L 21/02293 (20130101) H01L 21/02389 (20130101) H01L 21/02392 (20130101) H01L 21/02395 (20130101) H01L 21/02398 (20130101) H01L 21/02458 (20130101) H01L 21/02461 (20130101) H01L 21/02463 (20130101) H01L 21/02466 (20130101) H01L 21/02505 (20130101) H01L 21/02543 (20130101) H01L 21/02546 (20130101) H01L 21/02549 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230042736 | Tassev |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vladimir Tassev (Beavercreek, Ohio) |
| ABSTRACT | A method of performing heteroepitaxy comprises exposing a substrate to a carrier gas, a first precursor gas, a Group II/III element, and a second precursor gas, to form a heteroepitaxial growth of one of GaAs, AlAs, InAs, GaP, InP, ZnSe, GaSe, CdSe, InSe, ZnTe, CdTe, GaTe, HgTe, GaSb, InSb, AlSb, CdS, GaN, and AlN on the substrate; wherein the substrate comprises one of GaAs, AlAs, InAs, GaP, InP, ZnSe, GaSe, CdSe, InSe, ZnTe, CdTe, GaTe, HgTe, GaSb, InSb, AlSb, CdS, GaN, and AlN; wherein the carrier gas is H2, wherein the first precursor is HCl, the Group II/III element comprises at least one of Zn, Cd, Hg, Al, Ga, and In; and wherein the second precursor is one of AsH3 (arsine), PH3 (phosphine), H2Se (hydrogen selenide), H2Te (hydrogen telluride), SbH3 (hydrogen antimonide), H2S (hydrogen sulfide), and NH3 (ammonia). The process may be an HVPE (hydride vapor phase epitaxy) process. |
| FILED | Tuesday, October 04, 2022 |
| APPL NO | 17/937827 |
| CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 25/04 (20130101) Original (OR) Class C30B 25/18 (20130101) C30B 29/42 (20130101) C30B 29/44 (20130101) C30B 29/48 (20130101) C30B 29/406 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/3556 (20130101) G02F 1/3558 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0254 (20130101) H01L 21/0262 (20130101) H01L 21/02293 (20130101) H01L 21/02389 (20130101) H01L 21/02392 (20130101) H01L 21/02395 (20130101) H01L 21/02398 (20130101) H01L 21/02458 (20130101) H01L 21/02461 (20130101) H01L 21/02463 (20130101) H01L 21/02466 (20130101) H01L 21/02505 (20130101) H01L 21/02543 (20130101) H01L 21/02546 (20130101) H01L 21/02549 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230042816 | Xu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas); Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio); New Jersey Institute of Technology (Newark, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shouhuai Xu (Helotes, Texas); Songlin He (Newark, New Jersey); Eric Ficke (San Antonio, Texas); Mir Mehedi Ahsan Pritom (San Antonio, Texas); Huashan Chen (San Antonio, Texas); Qiang Tang (Cliffside Park, New Jersey); Qian Chen (San Antonio, Texas); Marcus Pendleton (Rome, New York); Laurent Njilla (Rome, New York) |
| ABSTRACT | The present disclosure presents blockchain-based cyber security management systems and related methods. One such method comprises obtaining cyber intelligence input data from a cyber defender computing device, wherein the cyber defender computing device manages network security of a network, wherein the cyber intelligence input data identifies a cyber attacker or a victim of a cyber attack on the network; executing one or more Cyber Security Management (CSM) functions with the cyber intelligence input data received from the cyber defender computing device and cyber data stored in the blockchain ledger, wherein the cyber data stored in the blockchain ledger provides details on a cyber attack on a network that is managed by another cyber defender computing device; and outputting an alert to the cyber defender computing device with a potential cyber attacker or potential victim of the cyber attack on the network managed by the cyber defender computing device. |
| FILED | Friday, April 29, 2022 |
| APPL NO | 17/733580 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 20/389 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/1416 (20130101) Original (OR) Class H04L 63/1441 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230042892 | WANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | IONQ, INC. (College Park, Maryland); University of Maryland (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qingfeng WANG (College Park, Maryland); Yunseong NAM (North Bethesda, Maryland) |
| ABSTRACT | Aspects of the present disclosure describe a method including compressing and uncompressing redundant quantum information encoded in quantum computers; processing quantum information in the compressed space; and computing, in response to determining the ansatz terms, a set of optimal transformations. |
| FILED | Wednesday, July 13, 2022 |
| APPL NO | 17/863787 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/20 (20220101) Original (OR) Class G06N 10/40 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230043658 | Evans et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DEKA Products Limited Partnership (Manchester, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher O. Evans (Amherst, New Hampshire); Keith D. Violette (Sandown, New Hampshire) |
| ABSTRACT | A system for powering a prosthetic arm is disclosed. The system includes at least one internal battery located in the prosthetic arm, at least one external battery connected to the prosthetic arm, and a master controller configured to connect either the at least one internal battery or the at least one external battery to a power bus to power the prosthetic arm. |
| FILED | Tuesday, October 11, 2022 |
| APPL NO | 17/963689 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/54 (20130101) A61F 2/70 (20130101) Original (OR) Class A61F 2/581 (20130101) A61F 2/585 (20130101) A61F 2002/7862 (20130101) A61F 2220/0075 (20130101) A61F 2250/008 (20130101) A61F 2250/0074 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230044044 | Bornholdt et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Mapp Biopharmaceutical, Inc. (San Diego, California); Albert Einstein College of Medicine (Bronx, New York); Adimab, LLC (Lebanon, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zachary A. Bornholdt (Encinitas, California); Larry Zeitlin (San Diego, California); Kartik Chandran (Brooklyn, New York); Anna Wec (Lebanon, New Hampshire); Laura Walker (Norwich, Vermont) |
| ABSTRACT | Described herein are compositions and methods for the prevention and treatment of ebolavirus infection. In certain embodiments of the present invention, monoclonal antibodies substantially similar to those described herein, as well as affinity matured variants thereof, alone or in combination, provide therapeutic efficacy in a patient against multiple species of ebolavirus. |
| FILED | Friday, July 01, 2022 |
| APPL NO | 17/856774 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/57 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230044517 | McDonley et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Timothy A. McDonley (Grove City, Ohio); Andrew Elliott (Columbus, Ohio); Adam Kimura (Lewis Center, Ohio); Katie T. Liszewski (Powell, Ohio); Thomas Kent (Columbus, Ohio); Josh Delozier (Columbus, Ohio); Benjamin Hayden (North Canton, Ohio) |
| ABSTRACT | The present disclosure provides a method for generating a spatially resolved netlist that includes generating a netlist based on integrated circuit (IC) layout data and standard cell library data, the netlist including cell and net definitions associated with the IC; determining position data for respective cells and nets based on the IC layout data; mapping the position data to respective cell and net definitions in the netlist; and generating a spatially resolved netlist that includes the mapped position data to respective cell and net definitions. |
| FILED | Friday, August 05, 2022 |
| APPL NO | 17/817904 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/327 (20200101) Original (OR) Class G06F 30/337 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230044579 | Ike et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Moses Ike (Atlanta, Georgia); Omar Alrawi (Atlanta, Georgia); Brendan D. Saltaformaggio (Atlanta, Georgia) |
| ABSTRACT | In method of identifying capabilities of a malware intrusion that has been detected by an intrusion detection system, a notification that the malware intrusion has been detected is received from the intrusion detection system. A memory image associated with the malware is then captured. The memory image is parsed and a prior execution context is reconstructed by loading a last central processing unit (CPU) state and memory state into a symbolic environment. Addresses and prototype summaries associated with the malware are extracted from the memory image from the symbolic environment. Paths that are possible for execution due to the malware based on the addresses and prototype summaries are determined. Each path is modeled and a probability of each path being executed with concrete data is assigned. Paths with a low probability of leaving a plurality of paths of interest are pruned. Application programming interfaces (APIs) detected in the plurality of paths of interest are matched to a repository of capability analysis plugins. Any application programming interface (API) that matches at least one plugin in the repository of capability analysis plugins is reported to an analyst. |
| FILED | Tuesday, May 03, 2022 |
| APPL NO | 17/735443 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/566 (20130101) Original (OR) Class G06F 2221/034 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230044652 | Ramakrishnan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MRL MATERIALS RESOURCES LLC (Beavercreek, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Abhishek Ramakrishnan (Beavercreek, Ohio); Daniel P. Satko (Centerville, Ohio); Ayman A. Salem (Dayton, Ohio) |
| ABSTRACT | Magnesium alloys and a process of manufacturing an article using magnesium alloys. During additive manufacturing, where the magnesium alloy is being deposited in a layer-by-layer manner, solidification of the melted portion of a deposited layer is performed in such a way as to ensure that about 15 percent or more of the portion being solidified includes a non-equilibrium eutectic constituent. This in turn reduces the likelihood of encountering solidification conditions that otherwise would lead to hot tearing problems. Further, upon subsequent heat treatment of the solidified layer, the eutectic constituents that were used for hot tearing resistance are dissolved so that the solidified layer may be returned to a substantially single-phase magnesium matrix such that desirable material properties such as improved flammability point, improved corrosion resistance and one or more of high yield strength, ultimate tensile strength and elongation are promoted. |
| FILED | Friday, May 06, 2022 |
| APPL NO | 17/738648 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/28 (20210101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) Alloys C22C 1/04 (20130101) C22C 23/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230044951 | Araujo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Frederico Araujo (Mahopac, New York); William Blair (Brighton, Massachusetts); Sanjeev Das (White Plains, New York); Jiyong Jang (Chappaqua, New York) |
| ABSTRACT | Program analysis is provided. An intermediate representation of a program is generated. A set of structured inputs is provided to the program. The set of structured inputs are derived from the intermediate representation. The program is executed using the set of structured inputs. A set of action steps is performed in response to observing a violation of a policy during execution of the program using the structured inputs. |
| FILED | Thursday, August 05, 2021 |
| APPL NO | 17/444497 |
| CURRENT CPC | Electric Digital Data Processing G06F 11/079 (20130101) G06F 21/577 (20130101) Original (OR) Class G06F 2221/033 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230045019 | Tassev |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vladimir Tassev (Beavercreek, Ohio) |
| ABSTRACT | A method of performing heteroepitaxy comprises exposing a substrate to a carrier gas, a first precursor gas, a Group II/III element, and a second precursor gas, to form a heteroepitaxial growth of one of GaAs, AlAs, InAs, GaP, InP, ZnSe, GaSe, CdSe, InSe, ZnTe, CdTe, GaTe, HgTe, GaSb, InSb, AlSb, CdS, GaN, and AlN on the substrate; wherein the substrate comprises one of GaAs, AlAs, InAs, GaP, InP, ZnSe, GaSe, CdSe, InSe, ZnTe, CdTe, GaTe, HgTe, GaSb, InSb, AlSb, CdS, GaN, and AlN; wherein the carrier gas is H2, wherein the first precursor is HCl, the Group II/III element comprises at least one of Zn, Cd, Hg, Al, Ga, and In; and wherein the second precursor is one of AsH3 (arsine), PH3 (phosphine), H2Se (hydrogen selenide), H2Te (hydrogen telluride), SbH3 (hydrogen antimonide), H2S (hydrogen sulfide), and NH3 (ammonia). The process may be an HVPE (hydride vapor phase epitaxy) process. |
| FILED | Tuesday, October 04, 2022 |
| APPL NO | 17/937791 |
| CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 25/04 (20130101) Original (OR) Class C30B 25/18 (20130101) C30B 29/42 (20130101) C30B 29/44 (20130101) C30B 29/48 (20130101) C30B 29/406 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/3556 (20130101) G02F 1/3558 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0254 (20130101) H01L 21/0262 (20130101) H01L 21/02293 (20130101) H01L 21/02389 (20130101) H01L 21/02392 (20130101) H01L 21/02395 (20130101) H01L 21/02398 (20130101) H01L 21/02458 (20130101) H01L 21/02461 (20130101) H01L 21/02463 (20130101) H01L 21/02466 (20130101) H01L 21/02505 (20130101) H01L 21/02543 (20130101) H01L 21/02546 (20130101) H01L 21/02549 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230045288 | Cambou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of Northern Arizona University (Flagstaff, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bertrand F. Cambou (Flagstaff, Arizona); Donald A. Telesca (Rome, New York); H. Shelton Jacinto (Rome, New York) |
| ABSTRACT | Systems and methods for the generation and use of session keys supporting secure communications between a client and server device are disclosed. The client device has or receives a password, which it hashes a predetermined first number of times. The hashed password is sent as a message digest to a server. The server applies the hashed password to a an array of PUF devices, and receives a response bitstream which is stored. The client later hashes the password a second predetermined number of times, which is less than the first predetermined number, and this second message digest is sent to the server. The server continues to hash the second message digest, generate PUF responses, and compare the result to the initially stored responses. The number of hashes necessary to achieve a match is the session key. |
| FILED | Tuesday, August 02, 2022 |
| APPL NO | 17/879697 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/14 (20130101) H04L 9/3236 (20130101) H04L 9/3278 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230045325 | Racioppi |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Luigi Racioppi (Durham, North Carolina) |
| ABSTRACT | Described is a method for promoting regeneration of hematopoietic stem and progenitor cells in a subject in need thereof. The method comprises administering to the subject a composition comprising a CaMKK2 inhibitor. The CaMKK2 inhibitor may be a small molecule inhibitor, such as STO-609. |
| FILED | Monday, August 01, 2022 |
| APPL NO | 17/878594 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/437 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230045356 | Gulbransen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David J. Gulbransen (Fairview, Texas); Jae H. Kyung (Redondo Beach, California); Chaffra A. Affouda (Santa Barbara, California) |
| ABSTRACT | An apparatus includes a sensor having an array of detectors. The sensor is configured to assign multiple detectors to a detector group corresponding to a block pixel. The sensor is also configured, for each frame of a set of frames, to apply a specified one of a set of mask patterns in order to select outputs of the detectors in the detector group and aggregate the selected outputs of the detectors in the detector group to determine pixel information for the block pixel. The apparatus also includes at least one processor configured to generate the frames using the pixel information for the block pixel, and upscale the portion of the at least one of the frames using the set of mask patterns to identify native pixels within the block pixel. |
| FILED | Friday, August 06, 2021 |
| APPL NO | 17/396436 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 3/40 (20130101) Pictorial Communication, e.g Television H04N 5/378 (20130101) H04N 5/3696 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230045360 | Garg |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Divyansh Garg (Stanford, California) |
| ABSTRACT | Systems and methods for imitation learning in accordance with embodiments of the invention are illustrated. One embodiment includes a method for imitation learning. The method includes steps for initializing a Q-function, training the Q-function using a non-adversarial objective based on a set of one or more expert trajectories, and determining a policy based on the trained Q-function. |
| FILED | Thursday, July 14, 2022 |
| APPL NO | 17/812672 |
| CURRENT CPC | Electric Digital Data Processing G06F 17/11 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20230037379 | Riley et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico); UNM Rainforest Innovations (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Ryan Riley (Albuquerque, New Mexico); Andrew De La Riva (Albuquerque, New Mexico); Stanley Shihyao Chou (Albuquerque, New Mexico); Abhaya Datye (Albuquerque, New Mexico) |
| ABSTRACT | Steam cracking of ethane, a non-catalytic thermochemical process, remains the dominant means of ethylene production. The severe reaction conditions and energy expenditure involved in this process incentivize the search for alternative reaction pathways and reactor designs which maximize ethylene yield while minimizing cost and energy input. According to the present invention, ethylene yields as high as 68% were obtained with a quartz open tube reactor without the use of a catalyst or a cofed stream of oxidizing agents. The open tube reactor design promotes simplicity, low cost, and negligible coke formation. Reactor designs can be optimized to improve the conversion of ethane to ethylene via non-oxidative dehydrogenation, an approach which shows promise for decentralized production of ethylene from natural gas deposits. |
| FILED | Thursday, July 14, 2022 |
| APPL NO | 17/864808 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 5/327 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230037396 | Brown et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States Department of Energy (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin Brown (Stony Brook, New York); Thomas Roser (Huntington, New York) |
| ABSTRACT | A system and method for storing information in a quantum computer using a quantum storage ring. The method comprises cooling ions in the quantum storage ring to a low temperature; and binding the ions into a lattice structure, forming an ion Coulomb crystal. |
| FILED | Thursday, September 29, 2022 |
| APPL NO | 17/956492 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Static Stores G11C 11/54 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 49/006 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230037610 | Walsh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Timothy F. Walsh (West Lafayette, Indiana); Nekoda van de Werken (Albuquerque, New Mexico); Chris Hammetter (Albuquerque, New Mexico); Michael B. Sinclair (Albuquerque, New Mexico); Harlan James Brown-Shaklee (Albuquerque, New Mexico); Joseph E. Bishop (Albuquerque, New Mexico); Wilkins Aquino (Durham, North Carolina) |
| ABSTRACT | A system for fabricating an acoustic metamaterial is provided. In an embodiment, a system for fabricating an acoustic metamaterial includes determining at least one tuned physical property for each of a plurality of micro-resonators according to a desired acoustic property of the acoustic metamaterial. For a particular physical property, a value of the tuned physical property for at least one of the plurality of micro-resonators is different from a value of the tuned physical property for at least one other of the plurality of micro-resonators. The system also includes an additively manufacturing device configured to form the acoustic metamaterial such that the acoustic metamaterial comprises a first structure and the plurality of micro-resonators embedded within the first structure. Forming the acoustic metamaterial is performed such that an actual physical property of each of the plurality of micro-resonators is equal to a corresponding tuned physical property for each of the plurality of micro-resonators. |
| FILED | Wednesday, October 19, 2022 |
| APPL NO | 17/968940 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/00 (20170801) B29C 64/10 (20170801) B29C 64/20 (20170801) B29C 64/25 (20170801) B29C 64/30 (20170801) B29C 64/40 (20170801) B29C 64/112 (20170801) B29C 64/176 (20170801) B29C 64/182 (20170801) B29C 64/205 (20170801) B29C 64/227 (20170801) B29C 64/245 (20170801) B29C 64/255 (20170801) B29C 64/307 (20170801) B29C 64/393 (20170801) Original (OR) Class Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2055/02 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 40/00 (20141201) B33Y 40/10 (20200101) B33Y 40/20 (20200101) B33Y 50/00 (20141201) B33Y 50/02 (20141201) B33Y 70/00 (20141201) B33Y 80/00 (20141201) B33Y 99/00 (20141201) Sound-producing Devices; Methods or Devices for Protecting Against, or for Damping, Noise or Other Acoustic Waves in General; Acoustics Not Otherwise Provided for G10K 11/162 (20130101) G10K 11/172 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230037628 | Wat et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amy Wat (Oakland, California); Gabriella King (Livermore, California); James Cahill (Livermore, California); Joshua Kuntz (Livermore, California); Wyatt Du Frane (Livermore, California); Marcus Worsley (Hayward, California); Logan Bekker (Pleasanton, California); Xiaojie Xu (Castro Valley, California); Yici Sun (Atlanta, Georgia); Joshua Deotte (Livermore, California) |
| ABSTRACT | Methods of forming joinery between components formed from dissimilar materials, and assemblies utilizing the joinery. The components include interface surfaces having complementary peaks and valleys that interlock. A compliant interface is formed between the interface surfaces and the interface can be configured to provide functionality. |
| FILED | Tuesday, August 03, 2021 |
| APPL NO | 17/392686 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 37/003 (20130101) Original (OR) Class C04B 37/008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230037790 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Uchicago Argonne, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | Uchicago Argonne, LLC (Chicago, Illinois) |
| INVENTOR(S) | Zhengcheng Zhang (Naperville, Illinois); Noah Mark Johnson (Chicago, Illinois) |
| ABSTRACT | Described herein are isosorbide-based electrolytes that are inexpensive, commercially available, green, and safe electrolytes. These electrolytes include a lithium salt, a solvent represented as a compound of Formula I, and optionally, a diluent. Such electrolytes have greatly enhanced cycle and calendar life when used with Si anodes, and exhibit very low leakage currents when compared to standard carbonate-based electrolytes. |
| FILED | Tuesday, July 05, 2022 |
| APPL NO | 17/857469 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0525 (20130101) H01M 10/0569 (20130101) Original (OR) Class H01M 2004/028 (20130101) H01M 2300/0034 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230037920 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (Fort Collins, Colorado) |
| ASSIGNEE(S) | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (Fort Collins, Colorado) |
| INVENTOR(S) | Eugene Y. Chen (Fort Collins, Colorado); Changxia Shi (Fort Collins, Colorado) |
| ABSTRACT | A monomer design strategy based on a bridged bicyclic thiolactone that produces stereo-disordered to perfectly stereo-ordered polythioesters is disclosed. The described polythioesters exhibit high crystallinity and full chemical recyclability. Such polymers possess intrinsic tacticity-independent crystallinity and chemical recyclability, tunable tacticities from stereo-disorder to perfect stereoregularity, as well as combined high-performance properties such as high thermal stability and crystallinity, and high mechanical strength, ductility and toughness. |
| FILED | Wednesday, December 02, 2020 |
| APPL NO | 17/781501 |
| CURRENT CPC | Heterocyclic Compounds C07D 333/78 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 75/26 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230038015 | MATHIS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DREXEL UNIVERSITY (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tyler S. MATHIS (Philadelphia, Pennsylvania); Yury GOGOTSI (Ivyland, Pennsylvania); Kathleen MALESKI (Mount Airy, Maryland) |
| ABSTRACT | Provided are enhanced MXene materials made from MAX-phase precursors that comprise an excess of metal A. The resultant enhanced MXenes exhibit improved stability over periods of days and months, particularly when stored in aqueous media. |
| FILED | Friday, January 22, 2021 |
| APPL NO | 17/759289 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/907 (20170801) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/72 (20130101) C01P 2002/74 (20130101) C01P 2002/82 (20130101) C01P 2002/84 (20130101) C01P 2002/85 (20130101) C01P 2002/88 (20130101) C01P 2004/03 (20130101) C01P 2004/04 (20130101) C01P 2004/24 (20130101) C01P 2006/40 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230039230 | Lawrie et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin J. Lawrie (Oak Ridge, Tennessee); Yun-Yi Pai (Oak Ridge, Tennessee); Chengyun Hua (Knoxville, Tennessee); Raphael C. Pooser (Knoxville, Tennessee); Claire E. Marvinney (Knoxville, Tennessee) |
| ABSTRACT | A system comprising a nonlinear medium (NLM), an optical transduction module, a dual homodyne detector and a processor is provided. The NLM receives at least a pump beam and issues the pump, probe and conjugate beams, where the beams are linearly polarized. Optics route the probe, the conjugate or both beams to the sample. The sample imparts polarization rotation to light that interacts therewith. The optical transduction module imparts to the interacted light an optical phase shift that is a 1:1 transduction of the polarization rotation, where at least one of the probe light or the conjugate light carries the imparted optical phase shift. The processor obtains the optical-phase shift based on respective detection signals from the dual homodyne detector and determines, based on the obtained optical-phase shift, at least one of a Faraday polarization rotation, a Kerr polarization rotation or a spin noise spectrum. |
| FILED | Friday, July 29, 2022 |
| APPL NO | 17/877308 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/31 (20130101) Original (OR) Class G01N 2201/10 (20130101) G01N 2201/0636 (20130101) G01N 2201/06113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230039237 | MUKERJEE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sanjeev MUKERJEE (Mansfield, Massachusetts); Qingying JIA (Belmont, Massachusetts); Li JIAO (Boston, Massachusetts) |
| ABSTRACT | Me-N—C catalysts, wherein Me can include a transition metal, Mn, Fe, Co, or a combination of metals with Me-INU moieties located at the exterior surface of the Me-N—C catalysts are produced by a chemical vapor deposition synthesis. The synthesis methods can utilize non-solid-contact pyrolysis wherein a metal salt can be vaporized. Gaseous metal from the vaporized metal salt can displace a metal M from the N—C zeolitic imidazolate framework. The non-solid-contact pyrolysis does not mix solid iron precursors (e.g., Me=Mn, Fe, or Co) with the solid N—C zeolitic imidazolate framework precursors during or before the synthesis, which improves the process compared to conventional methods. |
| FILED | Friday, October 30, 2020 |
| APPL NO | 17/782688 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/08 (20130101) C23C 16/4417 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/8867 (20130101) H01M 4/9041 (20130101) H01M 4/9083 (20130101) Original (OR) Class H01M 8/10 (20130101) H01M 2004/8689 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230039548 | D'Espaux et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Leopold D'Espaux (San Francisco, California); Jay D. Keasling (Berkeley, California) |
| ABSTRACT | The present invention provides for a genetically modified yeast cell comprising at least six or more of the following modifications: increased expression of Mus musculus fatty acid reductase, acetyl-CoA carboxylase, fatty acid synthase 1, fatty acid synthase 2, a mutant of the bottleneck enzyme encoded by ACC1 insensitive to post-transcriptional and post-translational repression, and/or a desaturase encoded by OLE1, and reduced expression of DGA1, HFD1, ADH6, and/or GDH1. The present invention provides a method for constructing the genetically modified yeast cell, and a method for producing a fatty alcohol from the genetically modified yeast cell. |
| FILED | Tuesday, June 21, 2022 |
| APPL NO | 17/845842 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0008 (20130101) C12N 9/93 (20130101) C12N 9/1029 (20130101) C12N 15/52 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/04 (20130101) Original (OR) Class Enzymes C12Y 101/01001 (20130101) C12Y 102/01084 (20150701) C12Y 203/0102 (20130101) C12Y 203/01085 (20130101) C12Y 604/01002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230039640 | Minguez et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Research Triangle Institute (Research Triangle Park, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ignacio Luz Minguez (Durham, North Carolina); Mustapha Soukri (Cary, North Carolina); Marty Lail (Raleigh, North Carolina) |
| ABSTRACT | A method, comprising i) contacting an aqueous solution of an organic ligand salt of the formula Ax(L-x) with a mesoporous material (MPM) to form an impregnated mesoporous salt material of the formula Ax(L-x)/MPM, ii) treating the impregnated mesoporous salt material with an aqueous acidic solution to form an impregnated mesoporous acid material of the formula Hx(L- x)/MPM, iii) contacting an aqueous solution of a metal precursor of the formula M+y(B)y with the impregnated mesoporous acid material to form an impregnated mesoporous metal organic framework precursor of the formula [M+y(B)y][Hx(L-x)]/MPM, and iv) at least one of 1) heating the impregnated mesoporous metal organic framework precursor in the absence of a solvent or 2) exposing the impregnated mesoporous metal organic framework precursor to a volatile vapor in the absence of a solvent such that the heating or the exposing forms a hybrid material of the formula (M+yL-x)/MPM, wherein the hybrid material comprises a nano-crystalline metal organic framework (MOF) embedded within the mesoporous material. |
| FILED | Friday, October 07, 2022 |
| APPL NO | 17/962217 |
| CURRENT CPC | Separation B01D 2253/108 (20130101) B01D 2253/204 (20130101) B01D 2259/4583 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/103 (20130101) B01J 20/226 (20130101) B01J 20/3236 (20130101) B01J 20/3265 (20130101) B01J 29/06 (20130101) B01J 31/1691 (20130101) Non-metallic Elements; Compounds Thereof; C01B 39/00 (20130101) C01B 39/02 (20130101) C01B 39/026 (20130101) Original (OR) Class C01B 39/48 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230039988 | Ziemkiewicz et al. |
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| FUNDED BY |
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| APPLICANT(S) | West Virginia University Board of Governors on Behalf of West Virginia University (Morgantown, West Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul F. Ziemkiewicz (Morgantown, West Virginia); James Constant (Foster, West Virginia); David K. Hoffman (Waltersburg, Pennsylvania); John D. Quaranta (Morgantown, West Virginia) |
| ABSTRACT | The present disclosure relates to processes for treating a coal associated material, e.g., acid mine drainage, while simultaneously recovering a high-grade rare earth preconcentrate suitable for extraction of commercially valuable rare earth oxides. Disclosed herein are methods for preparing a hydraulic pre-concentrate enriched in rare earth elements and critical minerals. Also disclosed herein are methods for preparing a pregnant leach solution from the disclosed hydraulic pre-concentrates. The present disclosure also relates to systems and plants for carrying out the disclosed processes. Also disclosed are compositions produced by the process disclosed herein in which the compositions comprise rare earth elements. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure. |
| FILED | Thursday, July 28, 2022 |
| APPL NO | 17/876332 |
| CURRENT CPC | Production and Refining of Metals; Pretreatment of Raw Materials C22B 3/20 (20130101) C22B 3/065 (20130101) Original (OR) Class C22B 59/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230040409 | Kertesz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-BATTELLE, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vilmos Kertesz (Oak Ridge, Tennessee); Gary J. Van Berkel (Oak Ridge, Tennessee) |
| ABSTRACT | A system for sampling a sample material includes a device for directing sample into a capture probe. The device for supplying sample material to the probe can be a device for radiating energy to the surface to eject sample from the sample material. A probe includes an outer probe housing having an open end. A liquid supply conduit has an outlet positioned to deliver liquid to the open end. An exhaust conduit removes liquid from the open end of the housing. The liquid supply conduit can be connectable to a liquid supply for delivering liquid at a first volumetric flow rate to the open end of the housing. A liquid exhaust system can be in fluid connection with the liquid exhaust conduit for removing liquid from the liquid exhaust conduit at a second volumetric flow rate, which exceeds the first volumetric flow rate such that gas with sample is withdrawn with the liquid. The probe can produce a vortex of liquid in the liquid exhaust conduit. A method for sampling a surface and a sampling probe system are also disclosed. |
| FILED | Monday, July 18, 2022 |
| APPL NO | 17/867156 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/10 (20130101) G01N 1/24 (20130101) Original (OR) Class G01N 2001/028 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/164 (20130101) H01J 49/0418 (20130101) H01J 49/0463 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230040941 | Rotsch et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Rotsch (Montgomery, Illinois); Jerry A. Nolen, JR. (Chicago, Illinois); Jeongseog Song (Lisle, Illinois); Sergey D. Chemerisov (Lisle, Illinois); James L. Bailey (Hinsdale, Illinois); Ronald T. Kmak (Homer Glen, Illinois) |
| ABSTRACT | A converter for generating photons from an electron beam is provided. The converter may include a plurality of converter plates (i) positioned perpendicular to an axis and (ii) arranged sequentially in a direction along the axis from a first converter plate of the plurality of converter plates to a last converter plate of the plurality of converter plates. The first converter plate may be configured to receive an electron beam traveling in the direction along the axis. Further, the first converter plate may have a thickness smaller than a thickness of the last converter plate, wherein a thickness of a particular converter plate is measured along the axis. |
| FILED | Tuesday, August 03, 2021 |
| APPL NO | 17/392803 |
| CURRENT CPC | Conversion of Chemical Elements; Radioactive Sources G21G 1/10 (20130101) Original (OR) Class Techniques for Handling Particles or Ionising Radiation Not Otherwise Provided For; Irradiation Devices; Gamma Ray or X-ray Microscopes G21K 5/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230041882 | Anderson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David C. Anderson (Knoxville, Tennessee); Anibal J. Ramirez-Cuesta (Knoxville, Tennessee); Matthew B. Stone (Oak Ridge, Tennessee); Amelia M. Elliott (Cleveland, Tennessee); Derek H. Siddel (Knoxville, Tennessee) |
| ABSTRACT | Collimators and other components for use in neutron scattering experiments or to provide neutron shielding in nuclear reactors or accelerator based neutron sources are produced by additive manufacturing from neutron absorbing material, such as boron carbide (B4C) or isotopically enriched boron carbide (10B). |
| FILED | Monday, August 01, 2022 |
| APPL NO | 17/878172 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/153 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) Nuclear Reactors G21C 11/028 (20130101) Protection Against X-radiation, Gamma Radiation, Corpuscular Radiation or Particle Bombardment; Treating Radioactively Contaminated Material; Decontamination Arrangements Therefor G21F 1/00 (20130101) Conversion of Chemical Elements; Radioactive Sources G21G 4/02 (20130101) Techniques for Handling Particles or Ionising Radiation Not Otherwise Provided For; Irradiation Devices; Gamma Ray or X-ray Microscopes G21K 1/046 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230042159 | CHERN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BWXT Nuclear Energy, Inc. (Charlotte, North Carolina) |
| ASSIGNEE(S) | BWXT Nuclear Energy, Inc. (Charlotte, North Carolina) |
| INVENTOR(S) | Andrew Harrison CHERN (Knoxville, Tennessee); Travis B. FRITTS (Knoxville, Tennessee); Daniel Walter GALICKI (Knoxville, Tennessee); Ryan Scott KITCHEN (Knoxville, Tennessee); Travis Adam MCFALLS (Knoxville, Tennessee); Elizabeth ELLIS (Knoxville, Tennessee) |
| ABSTRACT | Methodologies and manufacturing processes to manufacture components by electron beam melting additive manufacturing, particularly components of molybdenum or a molybdenum-based alloy and particularly of complex nuclear component geometries. Input parameters are provided for controlling electron beam melting additive manufacturing equipment, such as electron beam melting machines. The input parameters relate to various process steps, including build set-up, initial thermal treatment, initial layering of powder, pre-consolidation thermal treatment, consolidation, post-consolidation thermal treatment, indexing of layers, and post-build thermal treatment. The methodologies and manufacturing processes allow manufacture of components of molybdenum having a purity of ≥99.0% and a density of ≥99.75%. Metallographic cross-sections of the manufactured molybdenum components were porosity-free and crack-free. |
| FILED | Wednesday, May 25, 2022 |
| APPL NO | 17/752959 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/28 (20210101) B22F 12/17 (20210101) Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 15/002 (20130101) B23K 15/06 (20130101) B23K 15/0086 (20130101) Original (OR) Class B23K 37/003 (20130101) B23K 2103/08 (20180801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 40/00 (20141201) Nuclear Reactors G21C 21/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230042346 | Verba et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Department of Energy (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Circe Verba (Albany, Oregon); Mark L. McKoy (Bruceton Mills, West Virginia); Thomas J. Tarka (Pittsburgh, Pennsylvania); Scott Montross (Albany, Oregon); Jonathan Yang (Corvallis, Oregon) |
| ABSTRACT | One or more embodiments relates to a process for extracting Rare Earth Elements (REEs) from REE-bearing underclays, claystones, shales, coal-mining waste, and waste coal. In at least one embodiment the process includes contacting the REE-bearing underclays, claystones, shales, coal-mining waste, and waste coal with an Organic Acid Solution (OAS) comprising at least one organic acid and at least one ionic salt at a predetermined ambient temperature and predetermined pH; and separating the REE from the REE-bearing underclays, claystones, shales, coal-mining waste, and waste coal, forming REE+Yttrium (REY) concentrate. |
| FILED | Thursday, September 29, 2022 |
| APPL NO | 17/955731 |
| CURRENT CPC | Production and Refining of Metals; Pretreatment of Raw Materials C22B 3/22 (20130101) C22B 3/165 (20130101) Original (OR) Class C22B 59/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230042504 | Jiang |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Energy, United States Department of (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Junhua Jiang (Idaho Falls, Idaho) |
| ABSTRACT | A liquid metal cooled molten salt reactor having a liquid metal vessel connected to a gas chamber that is connected to a molten salt chamber that is connected with a hot liquid metal vessel. A fuel salt that is withdrawn from the fuel salt tank through a feeding tube into the molten salt chamber from which the fuel salt is withdrawn into a salt separator. A purging gas is inserted into the gas chamber and withdrawn. A liquid metal coolant is dispensed from the liquid metal vessel through a plurality of dispensing nozzles into the molten salt chamber. The liquid metal coolant flows through the molten salt into a hot liquid metal vessel and then through a liquid metal filter into a liquid metal pump. The liquid metal coolant flows through a thermal exchanger subsequently returning to the liquid metal vessel. |
| FILED | Tuesday, August 03, 2021 |
| APPL NO | 17/392599 |
| CURRENT CPC | Nuclear Reactors G21C 3/54 (20130101) G21C 15/12 (20130101) G21C 15/28 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230042802 | Whalen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Scott A. Whalen (West Richland, Washington); Darrell R. Herling (Kennewick, Washington); Xiao Li (Richland, Washington); MD. Reza-E-Rabby (Richland, Washington); Brandon Scott Taysom (West Richland, Washington); Glenn J. Grant (Benton City, Washington); Vineet V. Joshi (Richland, Washington); Rajib Kalsar (Richland, Washington); Tianhao Wang (Richland, Washington) |
| ABSTRACT | The present disclosure provides methods for preparing an extruded product from a solid billet. The methods can include providing an as-cast billet for extrusion; applying a simultaneous rotational shear and axial extrusion force to the as-cast billet to plasticize the as-cast billet; and extruding the plasticized as-cast billet with an extrusion die to form an extruded product. Methods for preparing extruded products from billets can also include: providing a billet for extrusion; while maintaining a majority of the billet below 100° C., applying a simultaneous rotational shear and axial extrusion force to one end of the billet to plasticize the one end of the billet; and extruding the plasticized one end of the billet with an extrusion die to form an extruded product. Methods for preparing an extruded product from a billet can also include providing a billet for extrusion; applying a simultaneous rotational shear and axial extrusion force to the billet to plasticize the billet; extruding the plasticized billet with an extrusion die to form an extruded product; and artificially aging the extruded product for less than the ASTM recommended amount of time. |
| FILED | Friday, September 30, 2022 |
| APPL NO | 17/957207 |
| CURRENT CPC | Manufacture of Metal Sheets, Wire, Rods, Tubes or Profiles, Otherwise Than by Rolling; Auxiliary Operations Used in Connection With Metal-working Without Essentially Removing Material B21C 23/218 (20130101) Original (OR) Class Working or Processing of Sheet Metal or Metal Tubes, Rods or Profiles Without Essentially Removing Material; Punching Metal B21D 37/16 (20130101) Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 20/001 (20130101) B23K 2103/15 (20180801) Changing the Physical Structure of Non-ferrous Metals and Non-ferrous Alloys C22F 1/04 (20130101) C22F 1/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230043177 | Walker et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dean Walker (Allen, Texas); Bryan D. Hornung (Plano, Texas); Tony M. Brewer (Plano, Texas); David M. Patrick (McKinney, Texas); Christopher A. Baronne (Allen, Texas) |
| ABSTRACT | Methods, systems, and devices for bias control for a memory device are described. A memory system may store indication of whether data is coherent. In some examples, the indication may be stored as metadata, where a first value indicates that the data is not coherent and a second value or a third value indicate that the data is coherent. When a processing unit or other component of the memory system processes a command to access data, the memory system may operate according to a device bias mode when the indication is the first value, and according to a host bias mode when the indication is the second value or the third value. |
| FILED | Wednesday, August 17, 2022 |
| APPL NO | 17/890032 |
| CURRENT CPC | Electric Digital Data Processing G06F 12/0815 (20130101) Original (OR) Class G06F 12/0868 (20130101) G06F 2212/1041 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230043638 | Frankel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | QUESTEK INNOVATIONS LLC (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dana Frankel (Evanston, Illinois); Marie Thomas (Evanston, Illinois) |
| ABSTRACT | Functionally graded materials may comprise a graded volume extending between a tungsten-based structure and a steel-based structure, where the graded volume comprises a plurality of additively manufactured layers. At least one of the plurality of additively manufactured layers may comprise a ternary element selected from vanadium and chromium. Some of the additively manufactured layers may further comprise aluminum. |
| FILED | Friday, August 13, 2021 |
| APPL NO | 17/401706 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/28 (20210101) Original (OR) Class B22F 2207/01 (20130101) B22F 2301/20 (20130101) B22F 2301/35 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230043712 | Culp et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States Department of Energy (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey T. Culp (Wexford, Pennsylvania); Wei Shi (Pittsburgh, Pennsylvania); Robert L. Thompson (Pittsburgh, Pennsylvania); Surya P. Tiwari (Pittsburgh, Pennsylvania); Kevin P. Resnik (White Oak, Pennsylvania); Lei Hong (Pittsburgh, Pennsylvania); Janice A. Steckel (Pittsburgh, Pennsylvania); David Hopkinson (Morgantown, West Virginia); Nicholas Siefert (Jefferson Hills, Pennsylvania) |
| ABSTRACT | One or more embodiments relate to a method for removing CO2 from a gaseous stream containing CO2 having the steps of contacting the gaseous stream containing CO2 with a solvent at a first temperature and a first pressure to dissolve said CO2 in said solvent, where the solvent is made up of at least one ester, and where said at least one ester has two or more alkyl-ester functional groups on a central hydrocarbon chain. |
| FILED | Monday, July 18, 2022 |
| APPL NO | 17/867094 |
| CURRENT CPC | Fuels Not Otherwise Provided for; Natural Gas; Synthetic Natural Gas Obtained by Processes Not Covered by Subclasses C10G, C10K; Liquefied Petroleum Gas; Adding Materials to Fuels or Fires to Reduce Smoke or Undesirable Deposits or to Facilitate Soot Removal; Firelighters C10L 3/104 (20130101) Original (OR) Class C10L 2290/12 (20130101) C10L 2290/541 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230044020 | Freiderich |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Consolidated Nuclear Security, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Melissa Ensor Freiderich (Oak Ridge, Tennessee) |
| ABSTRACT | Systems and methods for electroless plating a first metal onto a second metal in a molten salt bath including: a bath vessel holding a dry salt mixture including a dry salt medium and a dry salt medium of the first metal, and without the reductant therein, the dry salt mixture configured to be heated to form a molten salt bath; and the second metal is configured to be disposed in the molten salt bath and receive a pure coating of the first metal thereon by electroless plating in the molten salt bath, wherein the second metal is more electronegative than the first metal. |
| FILED | Monday, October 10, 2022 |
| APPL NO | 17/962598 |
| CURRENT CPC | Apparatus for Applying Fluent Materials to Surfaces, in General B05C 3/02 (20130101) B05C 3/005 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 18/31 (20130101) Original (OR) Class C23C 18/1619 (20130101) C23C 18/1628 (20130101) C23C 18/1637 (20130101) C23C 18/1676 (20130101) Processes for the Electrolytic Removal of Materials From Objects; Apparatus Therefor C25F 3/02 (20130101) C25F 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230044062 | Hovden et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan); UCHICAGO ARGONNE, LLC (Chicago, Illinois); DOW GLOBAL TECHNOLOGIES LLC (Midland, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Hovden (Ann Arbor, Michigan); Jonathan Schwartz (Ann Arbor, Michigan); Yi Jiang (Lemont, Illinois); Zichao Wendy Di (Darien, Illinois); Steve Rozeveld (Midland, Michigan) |
| ABSTRACT | Systems and methods for fused multi-modal electron microscopy are provided to generate quantitatively accurate 2D maps or 3D volumes with pixel/voxel values that directly reflect a sample's chemistry. Techniques are provided for combining annular dark field detector (ADF), annular bright field (ABF) and/or pixelated detector image data and energy dispersive X-rays (EDX) data and/or electron energy loss spectroscopy (EELS) data for a sample and generating chemical 2D and 3D maps by applying minimization optimization process. |
| FILED | Wednesday, July 27, 2022 |
| APPL NO | 17/875333 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/046 (20130101) G01N 23/2251 (20130101) Original (OR) Class Electric Discharge Tubes or Discharge Lamps H01J 37/28 (20130101) H01J 2237/2802 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230044696 | Saito et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tomonori Saito (Knoxville, Tennessee); Md Anisur Rahman (Knoxville, Tennessee) |
| ABSTRACT | A crosslinked adhesive composition comprising: (i) a polymer; (ii) solid particles embedded within the polymer; and (iii) a multiplicity of boronate linkages crosslinking between the polymer and solid particles, wherein the boronate linkages have the formula wherein the polymer and particles are connected to each other through the boronate linkages, and the crosslinked adhesive composition has an ability to bond surfaces and a further ability to thermally debond and rebond the surfaces. Also described herein is a method of bonding first and second surfaces together, the method comprising placing the above-described crosslinked adhesive composition onto the first surface and pressing the second surface onto the crosslinked adhesive composition on the first surface. |
| FILED | Tuesday, July 19, 2022 |
| APPL NO | 17/867861 |
| CURRENT CPC | Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 7/10 (20180101) C09J 7/381 (20180101) C09J 11/04 (20130101) C09J 11/06 (20130101) C09J 125/06 (20130101) Original (OR) Class C09J 2301/302 (20200801) C09J 2301/408 (20200801) C09J 2301/502 (20200801) C09J 2400/123 (20130101) C09J 2400/143 (20130101) C09J 2400/163 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230044783 | Garcia, JR. et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sortera Alloys, Inc. (Fort Wayne, Indiana) |
| ASSIGNEE(S) | Sortera Alloys, Inc. (Fort Wayne, Indiana) |
| INVENTOR(S) | Manuel Gerardo Garcia, JR. (Fort Wayne, Indiana); Nalin Kumar (Fort Worth, Texas) |
| ABSTRACT | An apparatus for classifying materials utilizing a vision system, which may implement an artificial intelligence system in order to identify or classify each of the materials, which may then be separated from a heap in a scrap yard into separate groups, such as other heaps, based on such an identification or classification. The artificial intelligence system may utilize a neural network, and be previously trained to recognize and classify certain types of materials. |
| FILED | Monday, October 24, 2022 |
| APPL NO | 17/972507 |
| CURRENT CPC | Postal Sorting; Sorting Individual Articles, or Bulk Material Fit to be Sorted Piece-meal, e.g by Picking B07C 5/04 (20130101) B07C 5/34 (20130101) B07C 5/342 (20130101) B07C 5/3422 (20130101) Original (OR) Class B07C 2501/0054 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230045680 | LAVERNIA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); National Technology & Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California); National Technology & Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| INVENTOR(S) | Enrique J. LAVERNIA (Laguna Beach, California); Baolong ZHENG (Woodland, California); Yizhang ZHOU (Irvine, California); Todd MONSON (Albuquerque, New Mexico) |
| ABSTRACT | A method of forming a consolidated component having a complex shape includes providing a first component having a first shape similar to the complex shape. The method further includes placing the first component in a chamber and surrounding the first component with a medium. The method further includes applying pressure and at least one of heat or electricity into the chamber to process the first component to form a consolidated component having the complex shape. |
| FILED | Wednesday, March 03, 2021 |
| APPL NO | 17/909301 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/054 (20220101) B22F 1/065 (20220101) B22F 3/15 (20130101) Original (OR) Class B22F 3/105 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20230037882 | Spivey et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Spivey (Durham, North Carolina); Kai Hedek (Durham, North Carolina); Ismail Inlek (Durham, North Carolina); Jungsang Kim (Durham, North Carolina); Zhubing Jia (Durham, North Carolina) |
| ABSTRACT | Technologies for an optomechanical system include an intermediate plate having a top surface with multiple tapped holes arranged in a grid. A pair of dowel pin holes surround each tapped hole in a linear pattern. Multiple optical blocks are coupled to the intermediate plate using dowel pins positioned in the dowel pin holes and corresponding dowel pin holes defined in the bottom surface of the optical block. Each optical block includes multiple optical elements coupled to the top surface of the optical block with dowel pins. A cryostat may be coupled to the intermediate plate. A cryo-package assembly is mounted inside a cryo chamber of the cryostat. The cryo-package assembly includes a cryo device such as an ion trap covered by a machined copper lid. The lid includes a meandering passageway to allow for differential pumping in order to achieve ultra-high vacuum within the cryo-package assembly. |
| FILED | Monday, August 08, 2022 |
| APPL NO | 17/883062 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 7/003 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230038480 | STEPHENS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland); THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (Washington, District of Columbia) |
| ASSIGNEE(S) | UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland); THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (Washington, District of Columbia) |
| INVENTOR(S) | Kristina STEPHENS (Takoma Park, Maryland); William E. BENTLEY (Annapolis, Maryland); Jessica Lynn LIBA (Drexel Hill, Pennsylvania); Ryan MCKAY (Peekskill, New York); Micaela EVERITT (Washington, District of Columbia) |
| ABSTRACT | The presently disclosure relates to a system and method for bioelectronic communications. In certain embodiments the system comprises a bacterial cell or cells that comprise a genetic system for high-efficiency over-expression and secretion of recombinant proteins in bacteria. In certain embodiments, the system and method operate in a “pump-then-burst release” fashion to rapidly achieve high yields extracellularly. In certain embodiments, the system and method include quorum sensing-derived regulation, which may enable auto-induction of a protein's expression and secretion. |
| FILED | Friday, July 08, 2022 |
| APPL NO | 17/861150 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/19 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 5/10 (20130101) C12N 2500/02 (20130101) C12N 2510/00 (20130101) C12N 2523/00 (20130101) C12N 2529/00 (20130101) C12N 2533/10 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230038709 | Ramani et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karthik Ramani (West Lafayette, Indiana); Tianyi Wang (West Lafayette, Indiana); Xun Qian (West Lafayette, Indiana); Fengming He (West Lafayette, Indiana) |
| ABSTRACT | An augmented reality (AR) application authoring system is disclosed. The AR application authoring system enables the real-time creation of freehand interactive AR applications with freehand inputs. The AR application authoring system enables intuitive authoring of customized freehand gesture inputs through embodied demonstration while using the surrounding environment as a contextual reference. A visual programming interface is provided with which users can define freehand interactions by matching the freehand gestures with reactions of virtual AR assets. Thus, users can create personalized freehand interactions through simple trigger-action programming logic. Further, with the support of a real-time hand gesture detection algorithm, users can seamlessly test and iterate on the authored AR experience. |
| FILED | Tuesday, July 26, 2022 |
| APPL NO | 17/814965 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/011 (20130101) G06F 3/017 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 13/20 (20130101) G06T 19/006 (20130101) G06T 2200/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230038963 | Peccia et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jordan Peccia (Hamden, Connecticut); Bridget Hegarty (Ann Arbor, Michigan) |
| ABSTRACT | A computer-implemented method includes: receiving a set of DNA sequences extracted from one or more dust samples collected from a structure; analyzing the sequences using a machine learning estimator, where the machine learning estimator has been trained to distinguish structures with mold growth due to water damage from structures without mold growth due to water damage; and determining if the structure has mold growth due to water damage. |
| FILED | Friday, December 11, 2020 |
| APPL NO | 17/783201 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 30/00 (20190201) Original (OR) Class G16B 40/20 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230039491 | Tretbar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Chase Tretbar (Irvine, California); Zhibin Guan (Irvine, California) |
| ABSTRACT | A polymer composition that operates as a polymer compatibilizer is provided. The polymer composition includes a plurality of polymer backbones cross-linked by cross-links that are Diels-Alder reaction products of at least one dienophile-containing moiety and at least one diene-containing moiety. |
| FILED | Tuesday, July 05, 2022 |
| APPL NO | 17/857842 |
| CURRENT CPC | Compositions of Macromolecular Compounds C08L 23/06 (20130101) Original (OR) Class C08L 2205/08 (20130101) C08L 2207/062 (20130101) C08L 2312/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230039934 | Gong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Songbin Gong (Champaign, Illinois); Yansong Yang (Urbana, Illinois); Ruochen Lu (Champaign, Illinois); Steffen Link (Urbana, Illinois) |
| ABSTRACT | A device includes a stack of at least two piezoelectric layers configured to propagate a Lamb wave in a mode having an order corresponding to a number of piezoelectric layers of the stack. The stack includes a first piezoelectric layer and a second piezoelectric layer disposed on the first piezoelectric layer. The first piezoelectric layer has a first cut plane orientation, and the second piezoelectric layer has a second cut plane orientation complementary to the first cut plane orientation. The device further includes an interdigitated transducer (IDT) disposed on at least a top surface of the stack or a bottom surface of the stack. In some embodiments, the device is an acoustic resonator. In some embodiments, the device is an acoustic delay line. |
| FILED | Wednesday, July 13, 2022 |
| APPL NO | 17/863586 |
| CURRENT CPC | Impedance Networks, e.g Resonant Circuits; Resonators H03H 9/13 (20130101) H03H 9/30 (20130101) H03H 9/02023 (20130101) H03H 9/02228 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230040397 | McCarthy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Drexel University (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | Drexel University (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Matthew McCarthy (Media, Pennsylvania); Deborah Kapilow (Berkeley Heights, New Jersey) |
| ABSTRACT | A backside thermography technique was developed based on the temperature sensitivity of laser-induced fluorescence in flowing two-dye solutions. The approach utilizes visible light and optically transparent packaging materials to obtain spatially resolved transient thermal measurements. This technique is compatible with optically transparent water-cooled packaging, which will allow for the characterization of processes where heat is added as well as removed. A setup was designed, constructed, and used to study the performance of seven two-dye Rhodamine B (RhB)-Rhodamine 110 (Rh110) fluorescent solutions. The effect of dye concentration ratio on sensitivity, maximum frame rate, and excitation area was characterized. The system was used to demonstrate in-situ temperature measurements showing the importance of two-dye light compensation, as well as backside thermography using a simple droplet contact method to investigate temporal response. Droplet contact experiments were conducted on actively heated and cooled surfaces to study local temperature and heat flux behavior during phase change. |
| FILED | Thursday, August 04, 2022 |
| APPL NO | 17/880751 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 5/046 (20130101) G01J 5/48 (20130101) Original (OR) Class G01J 5/061 (20130101) G01J 5/0887 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230040650 | Hu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of The University of Alabama (Tuscaloosa, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fei Hu (Tuscaloosa, Alabama); Yu Gan (Tuscaloosa, Alabama); Shengting Cao (Northport, Alabama); Xuefeng Wang (Tuscaloosa, Alabama) |
| ABSTRACT | Described herein are methods, systems and computer-program products for intra- and inter-gait classification for both symmetric and asymmetric gait patterns using images. |
| FILED | Friday, May 20, 2022 |
| APPL NO | 17/749754 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 20/20 (20190101) Image or Video Recognition or Understanding G06V 10/764 (20220101) G06V 40/25 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230040758 | Hersam et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois); THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark C. Hersam (Wilmette, Illinois); Megan E. Beck (St. Maries, Idaho); Vinod K. Sangwan (Evanston, Illinois); Amit R. Trivedi (Oak Park, Illinois); Ahish Shylendra (Chicago, Illinois) |
| ABSTRACT | A GHeT includes a bottom gate formed on a substrate; a first dielectric layer (DL) formed on the bottom gate; a monolayer film formed of an atomically thin material on the first DL; a bottom contact (BC) formed on part of the monolayer film; a second DL formed on the BC; a top contact (TC) formed on the second DL on top of the BC; a network of CNTs formed on the TC and the monolayer film, to define an overlap region with the monolayer film; a third DL formed on the CNT network, the monolayer film and the TC; and a top gate formed on the third DL and overlapping with the overlap region. Such GHeT design allows gate tunability of Gaussian peak position, height and width that define Gaussian transfer characteristic, thereby enabling simplified circuit architectures for various spiking neuron functions for emerging neuromorphic applications. |
| FILED | Tuesday, December 22, 2020 |
| APPL NO | 17/782728 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/049 (20130101) G06N 3/0481 (20130101) G06N 3/0635 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0003 (20130101) H01L 51/0017 (20130101) H01L 51/0048 (20130101) H01L 51/0554 (20130101) H01L 51/0562 (20130101) H01L 2251/301 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230040959 | Lovley et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Derek R. Lovley (Amherst, Massachusetts); Toshiyuki Ueki (Amherst, Massachusetts); David Walker (Boston, Massachusetts); Trevor Woodard (Shelburne, Massachusetts); Kelly Nevin Lovley (Amherst, Massachusetts) |
| ABSTRACT | The present invention provides, in various embodiments, genetically modified aerobic bacteria, polynucleotides and methods for expressing and/or harvesting electrically conductive protein nanowires (e-PNs). The present invention also provides e-PNs produced using the genetically modified aerobic bacteria, polynucleotides and methods. |
| FILED | Friday, November 20, 2020 |
| APPL NO | 17/778769 |
| CURRENT CPC | Peptides C07K 14/245 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/52 (20130101) C12N 15/72 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20230041658 — A METHOD AND APPARATUS TO CONDENSE MAGNESIUM VAPOR USING A FLUID-COOLED HEAT EXCHANGER
| US 20230041658 | CHUBUKOV et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BIG BLUE TECHNOLOGIES LLC (Westminster, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Boris CHUBUKOV (Boulder, Colorado); Aaron PALUMBO (Denver, Colorado); Jeremiah JEFFRIES (Boulder, Colorado) |
| ABSTRACT | A system and method that uses a high-temperature condenser to collect magnesium produced by thermal reduction, electrolysis, or distillation. The condenser is a common heat exchanger design (shell/tube, plate/plate, etc.) and uses a heat transfer fluid to cool and condense magnesium gas, e.g., to 200-900° C. under vacuum or pressure conditions. Solid or liquid magnesium is collected in the condenser along with any by-products or impurities at a purity greater than 35 wt-% Mg. Magnesium is subsequently liberated from the condenser by raising the temperature of the system, lowering the pressure, or both, to induce a phase change in the metal, such as melting or distillation, for further purification to, e.g., >90 wt-% Mg. |
| FILED | Friday, November 20, 2020 |
| APPL NO | 17/759086 |
| CURRENT CPC | Separation B01D 5/0012 (20130101) Original (OR) Class B01D 5/0015 (20130101) B01D 5/0045 (20130101) Production and Refining of Metals; Pretreatment of Raw Materials C22B 5/16 (20130101) C22B 9/02 (20130101) C22B 26/22 (20130101) Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 5/00 (20130101) F28D 2021/0022 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230042000 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona); OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yalin Wang (Tempe, Arizona); Duyan Ta (Gilbert, Arizona); Zhong-Lin Lu (Dublin, Ohio) |
| ABSTRACT | Method and systems provide a tool to quantify sensory maps of the brain. Cortical surfaces are conformally mapped to a topological disk where local geometry structures are well preserved. Retinotopy data are smoothed on the disk domain to generate a curve that best fits the retinotopy data and eliminates noisy outliers. A Beltrami coefficient map is obtained, which provides an intrinsic conformality measure that is sensitive to local changes on the surface of interest. The Beltrami coefficient map represents a function where the input domain is locations in the visual field and the output is a complex distortion measure at these locations. This function is also invertible. Given the boundaries and the Beltrami map of a flattened cortical region, a corresponding visual field can be reconstructed. The Beltrami coefficient map allows visualization and comparison of retinotopic map properties across subjects in the common visual field space. |
| FILED | Tuesday, October 04, 2022 |
| APPL NO | 17/938030 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0042 (20130101) A61B 5/055 (20130101) Original (OR) Class A61B 5/4064 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230042042 | Schafmeister et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Temple University-Of The Commonwealth System of Higher Education (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christian Schafmeister (Philadelphia, Pennsylvania); Justin Northrup (Philadelphia, Pennsylvania) |
| ABSTRACT | This invention provides unnatural amino acids as well as amino acid sequences, foldamers, macrocycles, and formulations comprising said unnatural amino acids. In one aspect of the invention, the unnatural amino acids or the formulation thereof are used to mimic natural amino acids or the formulations thereof in a subject in need thereof. |
| FILED | Thursday, December 17, 2020 |
| APPL NO | 17/785184 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4166 (20130101) Heterocyclic Compounds C07D 487/10 (20130101) Original (OR) Class C07D 487/20 (20130101) C07D 487/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230042180 | Feng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaming Feng (Baton Rouge, Louisiana); Guoqiang Li (Baton Rouge, Louisiana) |
| ABSTRACT | Provided herein are high-temperature shape memory photopolymers (HTSMP) and methods of making. The HTSMP has flame retardance and recovery stress of greater than 30 MPa. The HTSMP is formed from a polyacrylate and about 5 wt % to 15 wt % of a phosphorus containing photo-initiator (TPO), wherein the polyacrylate is polymerized by UV exposure of an acrylate monomer and the TPO. |
| FILED | Friday, September 30, 2022 |
| APPL NO | 17/957724 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 120/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230042430 | Geisler |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNLOCKED LABS INC. (Laramie, Wyoming) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christoph Geisler (Laramie, Wyoming) |
| ABSTRACT | The present disclosure relates to engineered microbial cells that have been engineered to include a uricase, a uric acid transporter, or both a uricase and a uric acid transporter. The engineered microbial cells of the present disclosure are useful in degrading uric acid inside the engineered microbial cell. The engineered microbial cells of the present disclosure are useful in methods of treating hyperuricemia. The engineered microbial cells of the present disclosure are also useful in methods of treating gout, and in particular chronic refractory gout. |
| FILED | Friday, January 08, 2021 |
| APPL NO | 17/792064 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/06 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 1/145 (20210501) Original (OR) Class C12N 9/0048 (20130101) C12N 2510/02 (20130101) Enzymes C12Y 107/03003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230042710 | FORD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | INNAMED, INC. (Philadelphia, Pennsylvania); AUBURN UNIVERSITY (Auburn, Alabama) |
| ASSIGNEE(S) | INNAMED, INC. (Philadelphia, Pennsylvania); AUBURN UNIVERSITY (Auburn, Alabama) |
| INVENTOR(S) | Katarena I. FORD (Auburn, Alabama); Niamat E. KHUDA (Auburn, Alabama); Asanka GURUKANDURE GEDARA (Auburn, Alabama); Christopher J. EASLEY (Auburn, Alabama); Subramaniam SOMASUNDARAM (Auburn, Alabama); Anup SINGH (Philadelphia, Pennsylvania); Eshwar INAPURI (Philadelphia, Pennsylvania) |
| ABSTRACT | Described herein are nucleic acid-based electrochemical proximity assays (ECPAs) for sample quantification. The invention may also include a biosensor with a sensing mechanism that uses a pair of aptamers or antibodies that bind the target of interest. More specifically, the invention relates to an electrochemical-based read out of a sensing mechanism that uses a nucleic acid-based proximity assay in conjunction with a pair of aptamers or antibodies for sample quantification. The biosensor or a set of biosensors can be used either as a standalone measurement system for a single analyte target or as a component of a multiplexed cartridge for multiple analytes. |
| FILED | Thursday, December 31, 2020 |
| APPL NO | 17/789161 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6825 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/3276 (20130101) G01N 27/3277 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230042816 | Xu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas); Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio); New Jersey Institute of Technology (Newark, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shouhuai Xu (Helotes, Texas); Songlin He (Newark, New Jersey); Eric Ficke (San Antonio, Texas); Mir Mehedi Ahsan Pritom (San Antonio, Texas); Huashan Chen (San Antonio, Texas); Qiang Tang (Cliffside Park, New Jersey); Qian Chen (San Antonio, Texas); Marcus Pendleton (Rome, New York); Laurent Njilla (Rome, New York) |
| ABSTRACT | The present disclosure presents blockchain-based cyber security management systems and related methods. One such method comprises obtaining cyber intelligence input data from a cyber defender computing device, wherein the cyber defender computing device manages network security of a network, wherein the cyber intelligence input data identifies a cyber attacker or a victim of a cyber attack on the network; executing one or more Cyber Security Management (CSM) functions with the cyber intelligence input data received from the cyber defender computing device and cyber data stored in the blockchain ledger, wherein the cyber data stored in the blockchain ledger provides details on a cyber attack on a network that is managed by another cyber defender computing device; and outputting an alert to the cyber defender computing device with a potential cyber attacker or potential victim of the cyber attack on the network managed by the cyber defender computing device. |
| FILED | Friday, April 29, 2022 |
| APPL NO | 17/733580 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 20/389 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/1416 (20130101) Original (OR) Class H04L 63/1441 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230042892 | WANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | IONQ, INC. (College Park, Maryland); University of Maryland (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qingfeng WANG (College Park, Maryland); Yunseong NAM (North Bethesda, Maryland) |
| ABSTRACT | Aspects of the present disclosure describe a method including compressing and uncompressing redundant quantum information encoded in quantum computers; processing quantum information in the compressed space; and computing, in response to determining the ansatz terms, a set of optimal transformations. |
| FILED | Wednesday, July 13, 2022 |
| APPL NO | 17/863787 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/20 (20220101) Original (OR) Class G06N 10/40 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230043444 | Tretbar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Chase Tretbar (Irvine, California); Zhibin Guan (Irvine, California); Jordan A. Castro (Clovis, California) |
| ABSTRACT | A vitrimer composition includes a first plurality of polymer backbones cross-linked with cross-linkers that include at least one siloxane moiety having formula 1: wherein R1, R2, R3, and R4 are each independently H or C1-6 alkyl. A catalyst that accelerates siloxane exchange is dispersed within the first plurality of polymer backbones. |
| FILED | Tuesday, July 05, 2022 |
| APPL NO | 17/857554 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 110/02 (20130101) C08F 110/06 (20130101) C08F 120/14 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/24 (20130101) Original (OR) Class C08J 2323/06 (20130101) C08J 2323/12 (20130101) C08J 2333/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230044530 | Hasty et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeff Hasty (San Diego, California); Arianna Miano (La Jolla, California); Michael Julius Liao (San Diego, California) |
| ABSTRACT | Provided herein are compositions and methods for modulating induction of quorum sensing in bacterial cells. For example, provided herein is a method of inducing method of inducing quorum sensing, where the method includes: culturing a bacterial strain, wherein the bacterial strain comprises a first nucleic acid sequence encoding a first activator polypeptide, wherein expression of the first activator polypeptide produces a quorum sensing molecule precursor; a second nucleic acid sequence encoding a second activator polypeptide, wherein expression of the second activator polypeptide produces a quorum sensing; a third nucleic acid sequence encoding a third activator polypeptide that is capable of activating the quorum sensing system; a fourth nucleic acid sequence encoding a gene of interest, and contacting the bacterial strain with an inducer molecule; and converting the inducer molecule into a quorum sensing molecule, thereby allowing induction of quorum sensing. |
| FILED | Friday, December 11, 2020 |
| APPL NO | 17/784547 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/00 (20130101) A61K 35/74 (20130101) Original (OR) Class Peptides C07K 14/195 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/93 (20130101) C12N 9/1029 (20130101) C12N 15/70 (20130101) C12N 15/635 (20130101) Enzymes C12Y 203/01184 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230044664 | Sinha et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ayan Sinha (West Lafayette, Indiana); Chiho Choi (West Lafayette, Indiana); Joon Hee Choi (West Lafayette, Indiana); Karthik Ramani (West Lafayette, Indiana) |
| ABSTRACT | A method for hand pose identification in an automated system includes providing map data of a hand of a user to a first neural network trained to classify features corresponding to a joint angle of a wrist in the hand to generate a first plurality of activation features and performing a first search in a predetermined plurality of activation features stored in a database in the memory to identify a first plurality of hand pose parameters for the wrist associated with predetermined activation features in the database that are nearest neighbors to the first plurality of activation features. The method further includes generating a hand pose model corresponding to the hand of the user based on the first plurality of hand pose parameters and performing an operation in the automated system in response to input from the user based on the hand pose model. |
| FILED | Monday, June 13, 2022 |
| APPL NO | 17/838887 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/017 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Image or Video Recognition or Understanding G06V 10/454 (20220101) G06V 20/653 (20220101) G06V 30/194 (20220101) G06V 40/11 (20220101) G06V 40/113 (20220101) Pictorial Communication, e.g Television H04N 13/271 (20180501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230045126 | Weitz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David A. Weitz (Cambridge, Massachusetts); Huidan Zhang (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure generally relates, in certain aspects, to droplet-based microfluidic devices and methods. In certain aspects, target nucleic acids contained within droplets are amplified within droplets in a first step, where multiple primers may be present. However, multiple primers may cause multiple target nucleic acids to be amplified within the droplets, which can make it difficult to identify which nucleic acids were amplified. In a second step, the amplified nucleic acids may be determined. For example, the droplets may be broken and the amplified nucleic acids can be pooled together and sequenced. As an example, new droplets may be formed containing the amplified nucleic acids, and those nucleic acids within the droplets amplified by exposure to certain primers. |
| FILED | Wednesday, January 13, 2021 |
| APPL NO | 17/790450 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5027 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6834 (20130101) C12Q 1/6876 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230045360 | Garg |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Divyansh Garg (Stanford, California) |
| ABSTRACT | Systems and methods for imitation learning in accordance with embodiments of the invention are illustrated. One embodiment includes a method for imitation learning. The method includes steps for initializing a Q-function, training the Q-function using a non-adversarial objective based on a set of one or more expert trajectories, and determining a policy based on the trained Q-function. |
| FILED | Thursday, July 14, 2022 |
| APPL NO | 17/812672 |
| CURRENT CPC | Electric Digital Data Processing G06F 17/11 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230045550 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of South Florida (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaopeng Li (Tampa, Florida); Qianwen Li (Tampa, Florida); Handong Yao (Tampa, Florida); Zhaohui Liang (Tampa, Florida) |
| ABSTRACT | A system for identifying autonomous vehicles includes at least one sensor that may be configured to provide sensor data associated with at least two vehicles. A pre-processing module may be coupled to the at least one sensor and may be configured to determine a set of data including at least car following data based on the sensor data. An autonomous vehicle (AV)/human-driven vehicle (HV) identification neural network may be coupled to the pre-processing module and configured to generate an AV/HV identifier for at least one of the at least two vehicles based on at least the car following data during a predetermined time period. |
| FILED | Tuesday, August 09, 2022 |
| APPL NO | 17/884411 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 19/01 (20130101) Image or Video Recognition or Understanding G06V 10/82 (20220101) G06V 10/764 (20220101) G06V 20/41 (20220101) G06V 20/58 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20230037962 | Markvicka et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric Markvicka (Brush, Colorado); Tom Frederick (Lincoln, Nebraska); Jack Mondry (Edina, Minnesota); Joe Bartels (Pittsburgh, Pennsylvania); Shane Farritor (Lincoln, Nebraska) |
| ABSTRACT | The various robotic medical devices include robotic devices that are disposed within a body cavity and positioned using a support component disposed through an orifice or opening in the body cavity. Additional embodiments relate to devices having arms coupled to a device body wherein the device has a minimal profile such that the device can be easily inserted through smaller incisions in comparison to other devices without such a small profile. Further embodiments relate to methods of operating the above devices. |
| FILED | Tuesday, October 11, 2022 |
| APPL NO | 17/963438 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 34/30 (20160201) Original (OR) Class A61B 90/361 (20160201) A61B 2034/302 (20160201) Technical Subjects Covered by Former US Classification Y10T 74/20317 (20150115) Y10T 74/20329 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230039217 | Haynie |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Aerojet Rocketdyne, Inc. (Sacramento, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carl R. Haynie (Sacramento, California) |
| ABSTRACT | A shoot-through protection circuit includes a current sensor providing a sensor signal connected to a comparator input via at least a burden resistor. A switch protection circuit including a protection input connected to an output of the comparator and a plurality of outputs. Each of the outputs is connected to a corresponding switch in a plurality of stacked switches. Wherein the switch protection circuit is configured to drive each switch of the plurality of stacked switches open in response to a positive output signal from the comparator. |
| FILED | Wednesday, February 19, 2020 |
| APPL NO | 17/792226 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 19/16571 (20130101) Emergency Protective Circuit Arrangements H02H 7/1225 (20130101) Original (OR) Class Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/08 (20130101) H02M 1/38 (20130101) Pulse Technique H03K 17/0822 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230042180 | Feng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaming Feng (Baton Rouge, Louisiana); Guoqiang Li (Baton Rouge, Louisiana) |
| ABSTRACT | Provided herein are high-temperature shape memory photopolymers (HTSMP) and methods of making. The HTSMP has flame retardance and recovery stress of greater than 30 MPa. The HTSMP is formed from a polyacrylate and about 5 wt % to 15 wt % of a phosphorus containing photo-initiator (TPO), wherein the polyacrylate is polymerized by UV exposure of an acrylate monomer and the TPO. |
| FILED | Friday, September 30, 2022 |
| APPL NO | 17/957724 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 120/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230042672 | Kang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America as represented by the Administrator of NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jin Ho Kang (Newport News, Virginia); Keith L. Gordon (Hampton, Virginia); Jeffrey A. Hinkley (Yorktown, Virginia); Sheila A. Thibeault (Hampton, Virginia) |
| ABSTRACT | Disclosed herein are composite materials comprising a siliconized carbon fiber fabric and polymeric sizing. In one embodiment, the polymeric sizing can be bismaleimide, an epoxy resin, or both. In another embodiment, the composite materials possess mechanical strength and durability and acceptable performance after extended periods of time in storage. In another embodiment, disclosed herein is a method for making the composite materials, the method including at least the steps of (a) siliconizing the carbon fiber fabric to produce a siliconized carbon fiber fabric; and (b) applying a polymeric sizing material to the siliconized carbon fiber fabric to create the composite material. In yet another embodiment, disclosed herein are composite materials formed by the disclosed process and articles comprising the composite materials including, but not limited to, camping equipment, military equipment, clothing, sporting equipment, aerospace equipment, wrinkle-free fabric, or any combination thereof. |
| FILED | Friday, August 05, 2022 |
| APPL NO | 17/881725 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 5/024 (20130101) B32B 5/262 (20210501) Original (OR) Class Treatment, Not Provided for Elsewhere in Class D06, of Fibres, Threads, Yarns, Fabrics, Feathers or Fibrous Goods Made From Such Materials D06M 13/51 (20130101) D06M 2101/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230043866 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado); California Institute of Technology (Pasadena, California); University of Iowa Research Foundation (Iowa City, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xu Wang (Superior, Colorado); Mihaly Horanyi (Boulder, Colorado); Benjamin Farr (Boulder, Colorado); Inseob Hahn (Glendale, California); Ulf Israelsson (Altadena, California); John Goree (Iowa City, Iowa) |
| ABSTRACT | Disclosed herein are methods and devices for cleaning a surface of a substrate having a layer of dust disposed thereon by ejecting at least a portion of the dust from the surface. The methods comprise irradiating the layer of dust with an electron beam, such that the electron beam irradiates a particle thereby inducing said particle to emit a plurality of secondary electrons; wherein at least a portion of the plurality of secondary electrons impinge two or more neighboring particles to thereby generate a secondary charge on the two or more neighboring particles, wherein the secondary charge on the two or more neighboring particles creates an electrostatic repulsive force between said particles, wherein the electrostatic repulsive force is sufficient to eject said particles from the surface. |
| FILED | Friday, August 05, 2022 |
| APPL NO | 17/881880 |
| CURRENT CPC | Cleaning in General; Prevention of Fouling in General B08B 6/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
20230037773 — SPARSE SAMPLING USING A PROGRAMMATICALLY RANDOMIZED SIGNAL MODULATING A CARRIER SIGNAL
| US 20230037773 | Principe et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Synchrotron Research, Inc. (Melbourne Beach, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edward Principe (Melbourne Beach, Florida); Andrew Stevens (Southlake, Texas); Conan Weiland (Manorville, New York); Jeffrey Hagen (Independence, Minnesota); Brian Kempshall (Cocoa, Florida); Kirk Scammon (Cocoa, Florida); Zachery Russell (Boone, North Carolina); Shane Didona (Durham, North Carolina); Mathieu Therezien (Vancouver, Canada); Tomas McIntee (Chapel Hill, North Carolina) |
| ABSTRACT | A method and a system are for sparse sampling utilizing a programmatically randomized signal for modulating a carrier signal. The system includes a compound sparse sampling pattern generator that generates at least one primary carrier signal, and at least one secondary signal. The at least one secondary signal modulates the at least one primary signal in a randomized fashion. |
| FILED | Thursday, August 05, 2021 |
| APPL NO | 17/394704 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 37/28 (20130101) Original (OR) Class H01J 37/222 (20130101) H01J 37/265 (20130101) H01J 2237/226 (20130101) H01J 2237/2802 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230037933 | Josell et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Josell (North Potomac, Maryland); Thomas Polk Moffat (Gaithersburg, Maryland) |
| ABSTRACT | A metallic grating is formed to include a substrate; a plurality of high aspect ratio trenches disposed in the substrate such that the high aspect ratio trenches are spaced apart from one another by a field surface of the substrate; a metallic superconformal filling formed and disposed in the high aspect ratio trenches; and a grating including a spatial arrangement of the high aspect ratio trenches that are filled with the metallic superconformal filling such that the metallic superconformal filling is void-free, and the high aspect ratio trenches are bottom-up filled with the metallic superconformal filling, wherein a height of the metallic superconformal filling is less than or equal to the height of the high aspect ratio trenches. |
| FILED | Tuesday, October 25, 2022 |
| APPL NO | 17/972816 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 5/1809 (20130101) G02B 5/1852 (20130101) Original (OR) Class G02B 5/1857 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230040758 | Hersam et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois); THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark C. Hersam (Wilmette, Illinois); Megan E. Beck (St. Maries, Idaho); Vinod K. Sangwan (Evanston, Illinois); Amit R. Trivedi (Oak Park, Illinois); Ahish Shylendra (Chicago, Illinois) |
| ABSTRACT | A GHeT includes a bottom gate formed on a substrate; a first dielectric layer (DL) formed on the bottom gate; a monolayer film formed of an atomically thin material on the first DL; a bottom contact (BC) formed on part of the monolayer film; a second DL formed on the BC; a top contact (TC) formed on the second DL on top of the BC; a network of CNTs formed on the TC and the monolayer film, to define an overlap region with the monolayer film; a third DL formed on the CNT network, the monolayer film and the TC; and a top gate formed on the third DL and overlapping with the overlap region. Such GHeT design allows gate tunability of Gaussian peak position, height and width that define Gaussian transfer characteristic, thereby enabling simplified circuit architectures for various spiking neuron functions for emerging neuromorphic applications. |
| FILED | Tuesday, December 22, 2020 |
| APPL NO | 17/782728 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/049 (20130101) G06N 3/0481 (20130101) G06N 3/0635 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0003 (20130101) H01L 51/0017 (20130101) H01L 51/0048 (20130101) H01L 51/0554 (20130101) H01L 51/0562 (20130101) H01L 2251/301 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20230039282 | Cho |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Inho Cho (Egg Harbor Township, New Jersey) |
| ABSTRACT | Various embodiments of the present invention are directed towards a system and method relating to depositing vapor in a sample. For example, a device includes a vapor source chamber configured to contain a vapor source material to generate vapor. An activation chamber is configured to contain a sample. The activation chamber is in fluid communication with the vapor source chamber to receive the vapor. A permeable separator divides the vapor source chamber and the activation chamber, and isolates the sample in the activation chamber while allowing vapor to pass between the vapor source chamber and the activation chamber. The device is sealable and configured to apply vacuum to the vapor and sample, to cause deposition of the vapor into the pumice stone samples. |
| FILED | Friday, October 21, 2022 |
| APPL NO | 17/971018 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 15/00 (20130101) B01J 19/0073 (20130101) B01J 2219/00162 (20130101) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 41/009 (20130101) C04B 41/62 (20130101) C04B 41/455 (20130101) C04B 41/4531 (20130101) Original (OR) Class C04B 2111/542 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230042863 | McCreery et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Zeteo Tech, Inc. (Sykesville, Maryland) |
| ASSIGNEE(S) | Zeteo Tech, Inc. (Sykesville, Maryland) |
| INVENTOR(S) | Thomas McCreery (Sykesville, Maryland); Wayne A. Bryden (Sykesville, Maryland) |
| ABSTRACT | Disclosed are microwave assisted methods and systems for decontaminating a variety of contaminated surfaces. The systems and methods comprise treating the surfaces with benign chemical formulations followed by exposing to microwave irradiation for short periods of time to achieve at least 6-log reduction in biological contaminants including spores of B. anthracis, B. thuringiensis, and P. roqueforti. Chemical formulations may comprise copper (II) chloride in water. The formulations may include a surfactant such as a polyethylene sorbitol ester surfactant. |
| FILED | Friday, September 30, 2022 |
| APPL NO | 17/958068 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 2/12 (20130101) Original (OR) Class A61L 2/18 (20130101) A61L 2202/14 (20130101) A61L 2202/16 (20130101) A61L 2202/25 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230044085 | Lim et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Jason Lim (Alexandria, Virginia); Daniel Boyd (Arlington, Virginia); Chang Ellison (Arlington, Virginia); William Washington (North Potomac, Maryland) |
| ABSTRACT | A provider system is connected to readers disposed at distances from the provider system. A secure local connection is established between the client device and the provider system via one of the readers. Before the client reaches an access touchpoint, the provider system receives from the client device a request for client access, the provider system sends to the client device a request for identification information of the client, and the client device sends client information associated with a first mobile identification credential (MIC) which the client device received from an authorizing party system (APS), the client having consented to release the client information to the provider system, and the client information having been verified. The provider system performs a liveness check of the client using live-captured biometric information at the access touchpoint, determines whether the liveness check is valid, and grants the request if the liveness check is valid. |
| FILED | Thursday, October 06, 2022 |
| APPL NO | 17/961091 |
| CURRENT CPC | Wireless Communication Networks H04W 12/06 (20130101) H04W 12/08 (20130101) H04W 12/71 (20210101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20230040418 | Myung et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); The United States Government as Represented by The Department of Veterans Affairs (NW Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Myung (Saratoga, California); Sei Kwang Hahn (Redwood City, California); Amy C. Madl (Los Altos, California) |
| ABSTRACT | Compositions and methods are provided for lamellar and defect reconstruction of corneal stromal tissue using supramolecular complexes that form a defined gel structure in situ. Such gels can serve as cellular or acellular matrices with or without certain encapsulated therapeutic factors to facilitate tissue regeneration such as multilayered re-epithelialization of wounded corneal stromal tissue. |
| FILED | Wednesday, February 24, 2021 |
| APPL NO | 17/760083 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/145 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/25 (20130101) A61K 31/728 (20130101) A61K 35/30 (20130101) Peptides C07K 5/1016 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230041528 | Damaser et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Cleveland Clinic Foundation (Cleveland, Ohio); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Margot S. Damaser (Cleveland Heights, Ohio); Steve Majerus (Cleveland Heights, Ohio); Mohamed Abdelhady (Cleveland, Ohio) |
| ABSTRACT | To perform urological diagnostics of a patient, detrusor pressure can be estimated using bladder pressure recordings from a single sensor. A signal comprising the bladder pressure data recorded by the sensor can be received. The bladder pressure data can include at least a detrusor pressure data component and a corrupting data component. An estimate of the corrupting data component can be extracted from the bladder pressure data. The detrusor pressure of the patient can be estimated based on the estimate of the corrupting data component and/or the estimate of the detrusor pressure data. An output indicative of the detrusor pressure of the patient can be provided based on the estimate of the detrusor pressure data component. |
| FILED | Wednesday, August 03, 2022 |
| APPL NO | 17/880109 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/205 (20130101) Original (OR) Class A61B 5/726 (20130101) A61B 5/6852 (20130101) A61B 5/7203 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230044670 | Boden et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott D. Boden (Atlanta, Georgia); Sreedhara Sangadala (Atlanta, Georgia) |
| ABSTRACT | The disclosure relates to compounds and compositions for forming bone and methods related thereto. In one embodiment, the disclosure relates to a composition comprising a compound disclosed herein, such as 2,4-diamino-1,3,5-triazine derivatives or salts thereof, for use in bone growth processes. In a typical embodiment, a bone graft composition is implanted in a subject at a site of desired bone growth or enhancement. |
| FILED | Wednesday, September 28, 2022 |
| APPL NO | 17/936184 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/53 (20130101) Original (OR) Class A61K 38/1875 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/54 (20130101) A61L 2300/412 (20130101) A61L 2430/02 (20130101) Heterocyclic Compounds C07D 251/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Office of the Director of National Intelligence (ODNI)
| US 20230037882 | Spivey et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Spivey (Durham, North Carolina); Kai Hedek (Durham, North Carolina); Ismail Inlek (Durham, North Carolina); Jungsang Kim (Durham, North Carolina); Zhubing Jia (Durham, North Carolina) |
| ABSTRACT | Technologies for an optomechanical system include an intermediate plate having a top surface with multiple tapped holes arranged in a grid. A pair of dowel pin holes surround each tapped hole in a linear pattern. Multiple optical blocks are coupled to the intermediate plate using dowel pins positioned in the dowel pin holes and corresponding dowel pin holes defined in the bottom surface of the optical block. Each optical block includes multiple optical elements coupled to the top surface of the optical block with dowel pins. A cryostat may be coupled to the intermediate plate. A cryo-package assembly is mounted inside a cryo chamber of the cryostat. The cryo-package assembly includes a cryo device such as an ion trap covered by a machined copper lid. The lid includes a meandering passageway to allow for differential pumping in order to achieve ultra-high vacuum within the cryo-package assembly. |
| FILED | Monday, August 08, 2022 |
| APPL NO | 17/883062 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 7/003 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230042892 | WANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | IONQ, INC. (College Park, Maryland); University of Maryland (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qingfeng WANG (College Park, Maryland); Yunseong NAM (North Bethesda, Maryland) |
| ABSTRACT | Aspects of the present disclosure describe a method including compressing and uncompressing redundant quantum information encoded in quantum computers; processing quantum information in the compressed space; and computing, in response to determining the ansatz terms, a set of optimal transformations. |
| FILED | Wednesday, July 13, 2022 |
| APPL NO | 17/863787 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/20 (20220101) Original (OR) Class G06N 10/40 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20230038066 | PERRY-EATON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wayne PERRY-EATON (Leesburg, Virginia); Bradley YDENS (Haymarket, Virginia) |
| ABSTRACT | A system for gathering one or more mail items. The system includes a first gathering mechanism configured to press against a first of the mail or other articles, wherein the first gathering mechanism is configured to expand from a compact state to an expanded state. The area of surface contact between a first one of the one or more mail items and the first gathering mechanism increases when the first holder mechanism is in the expanded state. |
| FILED | Tuesday, August 02, 2022 |
| APPL NO | 17/879646 |
| CURRENT CPC | Transport or Storage Devices, e.g Conveyors for Loading or Tipping, shop Conveyor Systems Or pneumatic Tube Conveyors B65G 47/901 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230041705 | Amato |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael J. Amato (Ocean Isle Beach, North Carolina) |
| ABSTRACT | Systems and methods for enhancing digitally informed delivery of delivery items, such as mail or packages. A delivery item has an associated digital resource(s), such as electronic text, a digital file, an image, a web page(s), or the like. The delivery item includes an indicia, such as a bar code, that provides access to, or references, the digital resource. When the delivery item is processed during transit from the sender to the recipient of the delivery item, the indicia is read, and the associated digital resource is identified therefrom. The delivery service transmits, to the recipient, an electronic notification indicating that the delivery item is enroute to the recipient and also indicating the associated digital resource. The recipient can then access the digital resource, e.g., the custom text, files, images or web pages associated with the delivery item. |
| FILED | Friday, October 07, 2022 |
| APPL NO | 17/961660 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/0838 (20130101) Original (OR) Class Pictorial Communication, e.g Television H04N 1/00222 (20130101) H04N 1/32144 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Housing and Urban Development (HUD)
| US 20230038963 | Peccia et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jordan Peccia (Hamden, Connecticut); Bridget Hegarty (Ann Arbor, Michigan) |
| ABSTRACT | A computer-implemented method includes: receiving a set of DNA sequences extracted from one or more dust samples collected from a structure; analyzing the sequences using a machine learning estimator, where the machine learning estimator has been trained to distinguish structures with mold growth due to water damage from structures without mold growth due to water damage; and determining if the structure has mold growth due to water damage. |
| FILED | Friday, December 11, 2020 |
| APPL NO | 17/783201 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 30/00 (20190201) Original (OR) Class G16B 40/20 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Environmental Protection Agency (EPA)
| US 20230044117 | Zerby et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | FFI IONIX IP, INC (Wilmington, Delaware) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jacob Zerby (Dover, Delaware); Bamdad Bahar (Georgetown, Delaware); Sai Yellamilli (Milford, Delaware) |
| ABSTRACT | An environmental control system employs an electrolysis cell utilizing an anion conducting membrane. A power supply is coupled across the anode and cathode of the electrolysis cell to drive reactions to reduce oxygen and/or carbon dioxide in an output gas flow. A cathode enclosure may be coupled with the electrolysis cell and provide an input gas flow and receive the output gas flow. A first electrolysis cell may be utilized to reduce the carbon dioxide concentration in an output flow that is directed to a second electrolysis cell, that reduces the concentration of oxygen. The oxygen and/or carbon dioxide may be vented from the system and used for an auxiliary purpose. An electrolyte solution may be configured in a loop from a reservoir to the anode, to provide a flow of electrolyte solution to the anode. Moisture from the cathode may be collected and provided to the anode. |
| FILED | Wednesday, December 30, 2020 |
| APPL NO | 17/790120 |
| CURRENT CPC | Separation B01D 53/02 (20130101) B01D 53/326 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
U.S. State Government
| US 20230039515 | Lux et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Regents of The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | The Board of Regents of The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Caroline de Gracia Lux (Austin, Texas); Jacques Lux (Austin, Texas); Alexander M. Vezeridis (Austin, Texas); Robert F. Mattrey (Austin, Texas) |
| ABSTRACT | Stable perfluorocarbon nanodroplet compositions with properties such as low-boiling points and small particle diameters are provided for improved performance in ultrasound imaging and therapeutic applications. Methods of producing stabilized nanodroplet compositions and methods of using the compositions are further provided to allow for improved performance in ultrasound imaging techniques and/or therapeutic applications. |
| FILED | Monday, August 08, 2022 |
| APPL NO | 17/882797 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/225 (20130101) Original (OR) Class A61K 49/226 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20230037328 | Collard et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Corey J. Collard (Plano, Texas); Jody D. Verret (Rockwall, Texas); Joseph C. Landry (Dallas, Texas) |
| ABSTRACT | Systems, devices, methods, and computer-readable media for determining planarity in a 3D data set are provided. A method can include receiving or retrieving three-dimensional (3D) data of a geographical region, dividing the 3D data into first contiguous regions of specified first geographical dimensions, determining, for each first contiguous region of the first contiguous regions, respective measures of variation, identifying, based on the respective measures of variation, a search radius, dividing the 3D data into respective second contiguous or overlapping regions with dimensions the size of the identified search radius, and determining, based on the identified search radius, a planarity of each of the respective second contiguous or overlapping regions. |
| FILED | Tuesday, July 27, 2021 |
| APPL NO | 17/443713 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 17/05 (20130101) Original (OR) Class G06T 2207/10028 (20130101) G06T 2207/30184 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230045150 | Grove et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Technologies Corporation (Farmington, Connecticut) |
| ASSIGNEE(S) | Raytheon Technologies Corporation (Farmington, Connecticut) |
| INVENTOR(S) | Donald E. Grove (Cobalt, Connecticut); James K. Berry (Bolton, Connecticut) |
| ABSTRACT | An engine control device may comprise a processor and a memory. The engine control device may be configured to modify a fuel flow based on a density of the fuel proximate a fuel nozzle. The engine control device may include a densimeter embedded in, or disposed proximate, the engine control device. The engine control device may include a temperature sensor embedded in, or disposed proximate, the engine control device. The engine control device may be electrically coupled to a fuel valve and/or configured to modulate the fuel valve based on a density of the fuel at the fuel valve. |
| FILED | Friday, October 14, 2022 |
| APPL NO | 17/966612 |
| CURRENT CPC | Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 3/24 (20130101) F02C 7/222 (20130101) F02C 7/232 (20130101) F02C 9/26 (20130101) Original (OR) Class F02C 9/263 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, February 09, 2023.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20230209.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page