FedInvent™ Patent Applications
Application Details for Thursday, February 16, 2023
This page was updated on Thursday, February 16, 2023 at 01:32 PM GMT
Department of Health and Human Services (HHS)
| US 20230045859 | Halperin et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); Doheny Eye Institute (Los Angeles, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California); Doheny Eye Institute (Los Angeles, California) |
| INVENTOR(S) | Eran Halperin (Santa Monica, California); Nadav Rakocz (Los Angeles, California); Jeffrey Chiang (Los Angeles, California); Muneeswar Gupta (Los Angeles, California); Srinivas Sadda (Los Angeles, California) |
| ABSTRACT | Deep learning methods and systems for detecting biomarkers within optical coherence tomography volumes using such deep learning methods and systems are provided. Embodiments predict the presence or absence of clinically useful biomarkers in OCT images using deep neural networks. The lack of available training data for canonical deep learning approaches is overcome in embodiments by leveraging a large external dataset consisting of foveal scans using transfer learning. Embodiments represent the three-dimensional OCT volume by “tiling” each slice into a single two dimensional image, and adding an additional component to encourage the network to consider local spatial structure. Methods and systems, according to embodiments are able to identify the presence or absence of AMD-related biomarkers on par with clinicians. Beyond identifying biomarkers, additional models could be trained, according to embodiments, to predict the progression of these biomarkers over time. |
| FILED | Monday, January 25, 2021 |
| APPL NO | 17/758625 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/102 (20130101) A61B 3/1225 (20130101) A61B 5/7275 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/10101 (20130101) G06T 2207/20081 (20130101) G06T 2207/30041 (20130101) Image or Video Recognition or Understanding G06V 10/44 (20220101) G06V 10/774 (20220101) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230046047 | Tsourkas et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadephia, Pennsylvania) |
| INVENTOR(S) | Andrew Tsourkas (Bryn Mawr, Pennsylvania); James Z. Hui (Philadlphia, Pennsylvania) |
| ABSTRACT | The invention relates to antibody conjugates (e.g., a bispecific antibody), drug and nanoparticle compositions and methods and compositions for generating them. This invention further relates to methods of using these compositions for imaging, diagnosing or treating a disease. |
| FILED | Wednesday, August 25, 2021 |
| APPL NO | 17/411815 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6851 (20170801) A61K 47/6889 (20170801) Original (OR) Class A61K 2039/572 (20130101) Peptides C07K 14/315 (20130101) C07K 16/468 (20130101) C07K 16/2803 (20130101) C07K 16/2809 (20130101) C07K 16/2887 (20130101) C07K 2317/31 (20130101) C07K 2317/52 (20130101) C07K 2317/622 (20130101) C07K 2319/70 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/48 (20130101) C12N 15/62 (20130101) Enzymes C12Y 304/2207 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230046078 | Ye |
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| FUNDED BY |
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| APPLICANT(S) | EMORY UNIVERSITY (Atlanta, Georgia) |
| ASSIGNEE(S) | EMORY UNIVERSITY (Atlanta, Georgia) |
| INVENTOR(S) | Keqiang Ye (Lilburn, Georgia) |
| ABSTRACT | Provided herein are methods of using 4-oxo-2-phenyl-4H-chromene-7,8-diyl bis(methylcarbamate) and derivatives thereof for treating or preventing a bone disorder. The methods include administering to the subject an effective amount of a compound of Formula I or a pharmaceutical composition as described herein. The bone disorder can include, for example, osteoporosis. Also provided herein are methods of inhibiting asparagine endopeptidase (AEP) activity in a cell and methods of promoting bone growth, increasing bone density, or increasing bone strength in a subject. Novel mechanisms of action in treating and preventing bone disorders are provided herein. |
| FILED | Friday, July 15, 2022 |
| APPL NO | 17/866008 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/352 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/08 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230046194 | Hecht et al. |
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| FUNDED BY |
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| APPLICANT(S) | Sidney Hecht (Phoenix, Arizona); Larisa (Liza) Dedkova (Scottsdale, Arizona); Rumit Maini (Tempe, Arizona); Sandipan Roy Chowdhury (Tempe, Arizona); Rakesh Paul (Baltimore, Maryland) |
| ASSIGNEE(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| INVENTOR(S) | Sidney Hecht (Phoenix, Arizona); Larisa (Liza) Dedkova (Scottsdale, Arizona); Rumit Maini (Tempe, Arizona); Sandipan Roy Chowdhury (Tempe, Arizona); Rakesh Paul (Baltimore, Maryland) |
| ABSTRACT | Modified ribosomes that were selected using a dipeptidyl-puromycin aminonucleoside are used to mediate site-specific incorporation of one or more peptides and peptidomimetics into protein in a cell free translation system. In addition, new fluorescent dipeptidomimetics have been synthesized and incorporated into proteins, as well as modified proteins containing one or more non-naturally occurring dipeptides. |
| FILED | Tuesday, July 19, 2022 |
| APPL NO | 17/813400 |
| CURRENT CPC | Heterocyclic Compounds C07D 263/34 (20130101) C07D 277/593 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/003 (20130101) C12N 15/11 (20130101) C12N 15/67 (20130101) Original (OR) Class Enzymes C12Y 105/01003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230046246 | Bier et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ethan Bier (San Diego, California); Victor Nizet (La Jolla, California); Jonathan Andres Valderrama (La Jolla, California); Surashree Kulkarni (La Jolla, California) |
| ABSTRACT | CRISPR-based gene-drive system for inhibiting antibiotic resistance of bacteria, including Escherichia coli that efficiently copies a gRNA cassette and adjacent cargo that are flanked with sequences homologous to the targeted gRNA/Cas9 cleavage site. This “pro-active” genetic system (Pro-AG) functionally inactivates an antibiotic resistance marker on a high copy number plasmid with greater efficiency than control CRISPR-based methods. Pro-AG can effectively edit large plasmids or single-copy genomic targets, or introduce functional genes, with numerous applications to biotechnology and biomedicine. |
| FILED | Monday, December 14, 2020 |
| APPL NO | 17/783255 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/70 (20130101) C12N 15/102 (20130101) Original (OR) Class C12N 15/8209 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230046305 | Bhattacharjee et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for the State University of New York (Amherst, New York) |
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| INVENTOR(S) | Arindam Bhattacharjee (Buffalo, New York); Kerri Pryce (Amherst, New York) |
| ABSTRACT | Described herein are peptides that can be used to treat pain or increase pain sensitivity in subject in need of treatment. Additionally, peptides of the present disclosure can be administered with an analgesic agent and/or anesthetic agent. Peptides of the present disclosure are suitable for use when a subject in need of treatment has an injury, a chronic disease, a chronic inflammation, Morton's neuroma, operative/post-operative pain, or a combination thereof. |
| FILED | Thursday, September 29, 2022 |
| APPL NO | 17/956031 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/45 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) Peptides C07K 7/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230046317 | Ye |
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| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia) |
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| INVENTOR(S) | Keqiang Ye (Atlanta, Georgia) |
| ABSTRACT | This disclosure relates to compounds that inhibit glutathione S-transferases (GSTs) and/or NAD(P)H:quinone oxidore-ductase 1 (NQO1) for uses in treating cancer. In certain embodiments, this disclosure relates to compositions and uses of N-(thia-zol-2-yl)-carboxamide derivatives such as a N-(5-nitrothiazol-2-yl)-carboxamide derivatives for treating cancer such as glioblastoma. In certain embodiments, this disclosure relates to pharmaceutical compositions comprising a N-(thiazol-2-yl)-carboxamide derivative such as a N-(5-nitrothiazol-2-yl)-carboxamide derivative which is a compound of formula (I), or derivative, prodrug or salt thereof and a pharmaceutically acceptable excipient, wherein X, R1, R2, and R3 substituents are reported herein. |
| FILED | Thursday, January 21, 2021 |
| APPL NO | 17/794323 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/58 (20130101) A61K 31/198 (20130101) A61K 31/337 (20130101) A61K 31/427 (20130101) Original (OR) Class A61K 31/506 (20130101) A61K 31/519 (20130101) A61K 31/704 (20130101) A61K 31/4745 (20130101) A61K 31/4985 (20130101) A61K 31/5377 (20130101) A61K 38/179 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230046649 | Malafa et al. |
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| FUNDED BY |
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| APPLICANT(S) | H. Lee Moffitt Cancer Center and Research Institute, Inc. (Tampa, Florida) |
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| INVENTOR(S) | Mokenge P. Malafa (Tampa, Florida); Jennifer Permuth (Tampa, Florida); Dung-Tsa Chen (Tampa, Florida) |
| ABSTRACT | The current invention pertains to miRNAs that are differentially expressed in samples of an individual having pancreatic cancer, or having a high risk of developing pancreatic cancer, as compared to the corresponding sample of an individual not having pancreatic cancer, or having low risk of developing pancreatic cancer, respectively. In certain embodiments, the miRNAs are differentially expressed in a tissue sample or blood plasma sample of an individual having a pancreatic lesion and having a high risk of developing pancreatic cancer as compared to the corresponding tissue sample or blood sample of an individual having the pancreatic lesion and having no risk or low risk of developing pancreatic cancer. These differentially expressed miRNAs can be used as biomarkers for diagnosis, treatment, and/or prevention of pancreatic cancer, particularly, in a subject having a pancreatic lesion. Microarray containing miRNAs indicative of the presence of pancreatic cancer, or having a high risk of pancreatic cancer development, particularly, in a subject having a pancreatic lesion, and methods of use of the microarrays are also provided. |
| FILED | Friday, July 29, 2022 |
| APPL NO | 17/816087 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) C12Q 2600/178 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230046662 | Britton et al. |
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| FUNDED BY |
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| APPLICANT(S) | Icahn School of Medicine at Mount Sinai (New York, New York) |
| ASSIGNEE(S) | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (New York, New York) |
| INVENTOR(S) | Graham J. Britton (New York, New York); Jeremiah J. Faith (New York, New York) |
| ABSTRACT | The present invention provides methods of diagnosing, treating, and monitoring the progression of inflammatory bowel disease in a subject, including, for example, by monitoring RORγt+Th or RORγt+Treg cell levels and treating the subject accordingly. |
| FILED | Saturday, December 19, 2020 |
| APPL NO | 17/786123 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/74 (20130101) Original (OR) Class A61K 35/742 (20130101) A61K 35/744 (20130101) A61K 35/745 (20130101) A61K 35/747 (20130101) A61K 2035/115 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5091 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230046776 | Pahan |
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| FUNDED BY |
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| APPLICANT(S) | Rush University Medical Center (Chicago, Illinois) |
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| INVENTOR(S) | Kalipada Pahan (Skokie, Illinois) |
| ABSTRACT | The present invention generally relates to compositions and methods for treating a neurological disorder in a subject, the method including administering to the subject in need of such treatment a composition including a therapeutically effective amount of a CCR5 antagonist. The CCR5 antagonist may be, for example, maraviroc. The neurological disorder may be, for example, Alzheimer's disease, Parkinson's disease, dementia with Lewy bodies or multiple system atrophy. |
| FILED | Tuesday, October 18, 2022 |
| APPL NO | 17/968264 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0053 (20130101) A61K 31/439 (20130101) Original (OR) Class A61K 31/499 (20130101) A61K 31/506 (20130101) A61K 31/4178 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/16 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230046834 | Elias et al. |
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| FUNDED BY |
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| APPLICANT(S) | Brown University (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jack A. Elias (Providence, Rhode Island); Chun Geun Lee (Woodbridge, Connecticut); Suchitra Kamle (Providence, Rhode Island) |
| ABSTRACT | Described herein are bispecific antibodies simultaneously targeting both CHI3L1 and the immune checkpoint molecule CTLA4. These antibodies manifest enhanced synergistic cytotoxic effects compared to the effects of individual CHI3L1 and CTLA4 antibodies, alone or in combination. Methods of treating tumors, including lung and brain tumors by administering the bispecific antibodies described herein are also provided. |
| FILED | Thursday, November 19, 2020 |
| APPL NO | 17/778375 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/3955 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/40 (20130101) C07K 16/2818 (20130101) Original (OR) Class C07K 2317/31 (20130101) C07K 2317/73 (20130101) C07K 2317/76 (20130101) C07K 2317/622 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230046906 | JARROLD et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin F. JARROLD (Bloomington, Indiana); Daniel BOTAMANENKO (Bloomington, Indiana) |
| ABSTRACT | A charge detection mass spectrometer (CDMS) includes an electrostatic linear ion trap (ELIT), a processor, and a memory having instructions stored therein executable by the processor to (a) control the ELIT to trap an ion, (b) collect ion measurement information as the trapped ion oscillates back and forth through the ELIT, the ion measurement information including charge induced by the ion on a charge detector of the ELIT during each pass of the ion through the ELIT and timing of the induced charges relative to one another, (c) process the ion measurement information in the time-domain for each of a plurality of sequential time windows of the ion measurement information to determine a charge magnitude of the ion during each time window, and (d) determine the magnitude of charge of the trapped ion based on the charge magnitudes of each of the time windows. |
| FILED | Wednesday, February 03, 2021 |
| APPL NO | 17/791979 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 49/025 (20130101) H01J 49/4245 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230047070 | Lam et al. |
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| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia); Georgia Tech Research Corporation (Atlanta, Georgia); Chapman University (Orange, California); Children's Healthcare of Atlanta, Inc. (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wilbur A. Lam (Decatur, Georgia); Caroline Hansen (Atlanta, Georgia); Yumiko Sakurai (Atlanta, Georgia); Andrew Lyon (Irvine, Georgia) |
| ABSTRACT | This disclosure relates to microcapsule particles for targeted delivery of drugs. In certain embodiments, the particles comprise polyelectrolyte polymers, e.g., layers of anionic polymers and cationic polymers. In certain embodiments, the particles have a fibrinogen coating. In certain embodiments, the particles contain a polysaccharide core and/or a polysaccharide coating encapsulating drugs, proteins, clotting agents, coagulation factors, or anticoagulants. In certain embodiments, this disclosure contemplates methods of using particles disclosed herein to prevent or reduce onset of or duration of bleeding. In certain embodiments, this disclosure contemplates methods of using particles disclosed herein to prevent or reduce onset of blood clotting. |
| FILED | Friday, September 23, 2022 |
| APPL NO | 17/934813 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5031 (20130101) Original (OR) Class A61K 9/5036 (20130101) A61K 9/5073 (20130101) A61K 9/5089 (20130101) A61K 38/37 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230047313 | Wang et al. |
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| FUNDED BY |
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| APPLICANT(S) | Children`s Medical Center Corporation (Boston, Massachusetts) |
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| INVENTOR(S) | Da-Zhi Wang (Newton, Massachusetts); Zhanpeng Huang (Las Vegas, Nevada); Jianming Liu (Boston, Massachusetts) |
| ABSTRACT | Methods of treating or reducing risk of developing cardiomyopathy or heart failure in a subject, comprising administering to a subject in need thereof a therapeutically effective amount of an inhibitor of NADPH oxidase 4 (Nox4). |
| FILED | Wednesday, December 16, 2020 |
| APPL NO | 17/786154 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/437 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230047584 | BRUZA et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Petr BRUZA (Lebanon, New Hampshire); Brian POGUE (Hanover, New Hampshire) |
| ABSTRACT | A system and method for depth-resolved imaging of fluorophore concentrations in tissue uses a pulsed light source stimulus wavelength to illuminate the tissue; and a time-gated electronic camera such as a single-photon avalanche detector camera to observe the tissue in multiple time windows after start of each light pulse. A filter-changer or tunable filter is between the tissue and the electronic camera with fluorescent imaging settings and a stimulus wavelength setting, and an image processor receives reflectance images and fluorescent emissions images from the time-gated camera and processes these images into depth and quantity resolved images of fluorophore concentrations in the tissue. |
| FILED | Monday, November 15, 2021 |
| APPL NO | 17/794297 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0071 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6408 (20130101) G01N 21/6458 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230047626 | ANDROPHY et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF IN DIANA UNIVERSITY (Bloomington, Indiana); KOVINA THERAPEUTICS, INC (Indianapolis, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ELLIOT J. ANDROPHY (Indianapolis, Indiana); SAMY MEROUEH (Carmel, Indiana); ZHIJIAN LU (Indianapolis, Indiana); Anne RIETZ (Indianapolis, Indiana) |
| ABSTRACT | Compositions and methods are provided for treating HPV infections including pre-malignant and cancers. Compounds that specifically bind to the HPV E6 protein and inactivate the protein are disclosed. |
| FILED | Monday, September 26, 2022 |
| APPL NO | 17/935408 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0002 (20130101) A61K 31/381 (20130101) Original (OR) Class A61K 38/10 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/20 (20180101) Heterocyclic Compounds C07D 215/06 (20130101) C07D 487/04 (20130101) C07D 495/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230047639 | Hawiger et al. |
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| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jack J. Hawiger (Nashville, Tennessee); Jozef Zienkiewicz (Nashville, Tennessee) |
| ABSTRACT | The present invention relates to compositions and methods for treating autoimmune, microbial, metabolic, neoplastic, and posttraumatic diseases mediated by inflammation in a subject. Compositions and methods including at least one importin beta-selective nuclear transport modifier (NTM) and/or at least one importin alpha-selective NTM, and/or at least one importin alpha-specific NTM, and/or at least one inhibitor of importin alpha and importin beta complex formation may be administered to a subject to modulate the transport of transcription factors, mediated by nuclear import adaptors, into the nucleus of a cell resulting in a decrease or abrogation of inflammation. |
| FILED | Tuesday, June 21, 2022 |
| APPL NO | 17/845144 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/167 (20130101) A61K 31/192 (20130101) A61K 38/12 (20130101) A61K 38/16 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) Peptides C07K 14/47 (20130101) C07K 14/50 (20130101) C07K 14/4702 (20130101) C07K 2319/00 (20130101) C07K 2319/09 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230047669 | Josephs et al. |
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| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric Josephs (Durham, North Carolina); Dewran Kocak (Durham, North Carolina); Piotr Marszalek (Durham, North Carolina); Charles A. Gersbach (Chapel Hill, North Carolina) |
| ABSTRACT | Disclosed herein are optimized guide RNAs (gRNAs) that have increased target binding specificity and reduced off-target binding. Further disclosed herein are methods of designing and using the optimized gRNAs. |
| FILED | Tuesday, August 02, 2022 |
| APPL NO | 17/879506 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) Original (OR) Class C12N 15/111 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/10 (20190201) G16B 15/30 (20190201) G16B 25/00 (20190201) G16B 30/10 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230047712 | Curtis et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Christina Curtis (Stanford, California); Katherine McNamara (Stanford, California) |
| ABSTRACT | Methods of treatment based on a breast cancer's biomolecule response to targeted treatment are provided. Expression levels of various biomolecules or histological assessment of infiltrating immune cells after initiation of human epidermal growth factor receptor 2 (HER2) targeted treatment can be used to determine whether a breast cancer will achieve a pathologic complete response. Based on likelihood of a pathologic complete response, a breast cancer can be treated accordingly. |
| FILED | Thursday, October 29, 2020 |
| APPL NO | 17/755519 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/158 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 25/10 (20190201) G16B 40/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230047753 | Szablowski et al. |
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| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jerzy O. Szablowski (Pasadena, California); Hongyi Li (Pasadena, California); John E. Heath (Stanford, California); Mikhail G. Shapiro (Pasadena, California) |
| ABSTRACT | Disclosed herein include adeno-associated virus (AAV) acoustic targeting peptides. An AAV comprising the AAV acoustic targeting peptide can exhibit increased transduction at site(s) of focused ultrasound blood-brain barrier opening (FUS-BBBO), increased neuronal tropism, and diminished transduction of peripheral organs. Disclosed herein include recombinant adeno-associated virus (rAAV) comprising an AAV acoustic targeting peptide disclosed herein. Also provided herein include methods of delivering an agent to one or more target brain region(s) of a subject. |
| FILED | Friday, July 22, 2022 |
| APPL NO | 17/814384 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8616 (20130101) Original (OR) Class C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230047844 | Bhattacharya et al. |
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| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martha Bhattacharya (Tucson, Arizona); Tally Largent-Milnes (Tucson, Arizona) |
| ABSTRACT | The present invention features methods and compositions for preventing, inhibiting, or reducing the sensation of itch (pruritus) by modulating the gene expression of TMEM184B. Modulating the gene expression of TMEM184B may comprise increasing Tmem184B protein expression, increasing Tmem184B protein activity or both. Furthermore, the methods and compositions described herein may activate the Tmem184B protein or activate a pathway leading to Tmem184B activation. Additionally, the methods and compositions for modulating the gene expression of TMEM184B may be used to help prevent or treat certain diseases or conditions such as dermatitis. |
| FILED | Monday, January 25, 2021 |
| APPL NO | 17/794939 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/127 (20130101) A61K 31/7105 (20130101) A61K 38/177 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230047941 | SCHWABE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alector LLC (South San Francisco, California) |
| ASSIGNEE(S) | Alector LLC (South San Francisco, California) |
| INVENTOR(S) | Tina SCHWABE (San Francisco, California); Michael KURNELLAS (San Francisco, California); Arnon ROSENTHAL (Woodside, California); Robert PEJCHAL (Lebanon, New Hampshire); Anthony B. COOPER (White River Junction, Vermont) |
| ABSTRACT | The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, affinity-matured, humanized antibodies, antibody fragments, etc., that specifically bind a Sortilin protein, e.g., human Sortilin or mammalian Sortilin, and have improved and/or enhanced functional characteristics, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof. |
| FILED | Thursday, June 09, 2022 |
| APPL NO | 17/836644 |
| CURRENT CPC | Peptides C07K 16/286 (20130101) Original (OR) Class C07K 2317/31 (20130101) C07K 2317/52 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/94 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230048010 | Sinclair et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David A. Sinclair (Cambridge, Massachusetts); Yuancheng Lu (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein are engineered nucleic acids (e.g., expression vectors, including viral vectors, such as lentiviral vectors, adenoviral vectors, AAV vectors, herpes viral vectors, and retroviral vectors) that encode OCT4; KLF4; SOX2; or any combination thereof that are useful, for example, in inducing cellular reprogramming, tissue repair, tissue regeneration, organ regeneration, reversing aging, or any combination thereof. Also provided herein are recombinant viruses (e.g., lentiviruses, alphaviruses, vaccinia viruses, adenoviruses, herpes viruses, retroviruses, or AAVs) comprising the engineered nucleic acids (e.g., engineered nucleic acids), engineered cells, compositions comprising the engineered nucleic acids, the recombinant viruses, engineered cells, engineered proteins, chemical agents that are capable of activating expression of OCT4; KLF4; SOX2; or any combination thereof, an engineered protein selected from the group consisting of OCT4; KLF4; SOX2; or any combination thereof, an antibody capable of activating expression of OCT4; KLF4; SOX2; or any combination thereof, and methods of treating a (e.g., ocular disease), preventing a disease (e.g., ocular disease), regulating (e.g., inducing or inducing and then stopping) cellular reprogramming, regulating tissue repair, regulating tissue regeneration, or any combination thereof). |
| FILED | Friday, September 27, 2019 |
| APPL NO | 17/280384 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/65 (20130101) A61K 38/1709 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230048025 | Nakai et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | OREGON HEALTH and SCIENCE UNIVERSITY (Portland, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hiroyuki Nakai (Portland, Oregon); Kei Adachi (Portland, Oregon) |
| ABSTRACT | Recombinant adeno associated viral vectors are disclosed. These include AAV8 or AAV9 derived vectors that include capsid proteins with mutations that confer upon the vector particular characteristics such as the ability to transduce or avoid (detarget) particular tissues, to be retained longer in the blood, or to be internalized in a cell without viral expression. |
| FILED | Thursday, December 21, 2017 |
| APPL NO | 16/472793 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 2750/14122 (20130101) C12N 2750/14143 (20130101) C12N 2750/14171 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230048049 | Argun et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Giner, Inc. (Newton, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Avni A. Argun (Newton, Massachusetts); Muhit Rana (Southborough, Massachusetts); Badawi M. Dweik (Foxborough, Massachusetts); Niazul I. Khan (Westmont, Illinois); Andrew Weber (Medford, Massachusetts) |
| ABSTRACT | Method and system for detecting drug and/or drug metabolites in a liquid sample, such as a wastewater sample. According to one embodiment, the method involves providing a device that includes a graphene field effect transistor and a first aptamer coupled to the graphene field effect transistor in a first well, the first aptamer being selective for a first drug or drug metabolite. Next, a liquid sample is introduced to the first aptamer of the device. Next, a sweeping liquid gate voltage is applied to the device to obtain a resistance versus liquid gate voltage plot for the device. Next, the Dirac voltage shift, if any, in the liquid gate voltage plot for the device is used to determine the presence and/or quantity of the drug or drug metabolite. Additional aptamers selective for different drugs or drug metabolites of interest may also be included in other wells of the device. |
| FILED | Friday, August 12, 2022 |
| APPL NO | 17/887347 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/06 (20130101) Original (OR) Class G01N 33/9486 (20130101) G01N 33/54373 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230048203 | Xu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Patricia Xu (Ithaca, New York); Robert F. Shepherd (Ithaca, Indiana) |
| ABSTRACT | Provided are three dimensional, stretchable, optical sensor networks that can localize deformations. The devices described herein are suitable for uses in soft robots to determine the position of external contact, such as touching, and possibly internal deformations that may be caused by actuation. Sensor networks of the present disclosure contain a substrate, such as a 3D lattice, and cores having a cladding, such as air. Light passes through the cores and upon deformation of the substrate, cores may come into contact, allowing light to couple between cores due to frustrated total internal reflection. The resulting changes in intensity in the cores can be used to determine the placement and magnitude of deformation. |
| FILED | Monday, September 12, 2022 |
| APPL NO | 17/943184 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 11/16 (20130101) Optical Elements, Systems, or Apparatus G02B 6/125 (20130101) G02B 6/1221 (20130101) Original (OR) Class G02B 2006/12097 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230048266 | Bayley et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Oxford University Innovation Limited (Oxford, United Kingdom) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Hagan Pryce Bayley (Oxford Oxfordshire, United Kingdom); Andrew Heron (Oxford Oxfordshire, United Kingdom); Gabriel Villar (Oxford Oxfordshire, United Kingdom) |
| ABSTRACT | The invention provides a droplet encapsulate comprising: a drop of a hydrophobic medium; a peripheral layer of non-polymeric amphipathic molecules around the surface of the drop; and an aqueous droplet within the peripheral layer, the aqueous droplet comprising: (a) an aqueous medium and (b) an outer layer of non-polymeric amphipathic molecules around the surface of the aqueous medium. The invention also provides processes for preparing the droplet encapsulates. Various uses of the droplet encapsulates are also described, including their use as drug delivery vehicles, in synthetic biology, and in the study of membrane proteins. |
| FILED | Wednesday, June 29, 2022 |
| APPL NO | 17/853000 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/50 (20130101) Original (OR) Class A61K 9/113 (20130101) A61K 9/1075 (20130101) A61K 31/085 (20130101) A61K 49/0002 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/02 (20130101) B01J 13/025 (20130101) Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 67/0097 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/2984 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230048369 | Ferrari et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in The City of New York (New York, New York); Children's Hospital of Philadelphia (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Giovanni Ferrari (Hastings on Hudson, New York); Antonio Frasca (Bronx, New York); Yingfei Xue (Mountain Lakes, New Jersey); Andrey Zakharchenko (Philadelphia, Pennsylvania); Michael Chorny (Philadelphia, Pennsylvania); Robert Levy (Philadelphia, Pennsylvania); Ivan Alferiev (Philadelphia, Pennsylvania) |
| ABSTRACT | Compositions and methods for mitigating SVD mechanisms in BHV, including non-calcific SVD mechanisms, are provided. |
| FILED | Wednesday, January 13, 2021 |
| APPL NO | 17/792694 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/24 (20130101) Original (OR) Class Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/3625 (20130101) A61L 2430/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230048370 | Lew et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Matthew Lew (St. Louis, Missouri); Tingting Wu (St. Louis, Missouri) |
| ABSTRACT | Systems, devices, and methods for producing an optimized phase mask for use in a single-molecule orientation localization microscopy (SMOLM) imaging system are disclosed. |
| FILED | Thursday, August 04, 2022 |
| APPL NO | 17/880648 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 21/6445 (20130101) G01N 21/6458 (20130101) Original (OR) Class G01N 2021/6439 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230048598 | JARROLD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin F. JARROLD (Bloomington, Indiana); David E. CLEMMER (Bloomington, Indiana); Benjamin E. DRAPER (Bloomington, Indiana); Lauren F. BARNES (Bloomington, Indiana) |
| ABSTRACT | A method for reducing heterogeneity of a virus preparation may include generating virus ions from the virus preparation, repeatedly increasing at least one of a temperature and an incubation period at the increased temperature of at least one of the virus preparation and the generated virus ions, measuring mass-to-charge ratios and charge magnitudes of at least some of the generated virus ions at each increase of the at least one of the temperature and the incubation period, determining a mass spectrum at each increase of the at least one of the temperature and the incubation period based on values of the respective mass-to-charge ratios and charge magnitudes, and determining, based on the mass spectrums, optimum ones of the temperature and the incubation period which together minimize, or at least reduce, a heterogeneity of the virus preparation without aggregation of virus capsids in the virus preparation. |
| FILED | Wednesday, February 03, 2021 |
| APPL NO | 17/791981 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class C12N 2750/14121 (20130101) C12N 2750/14152 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6848 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230048872 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (URBANA, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhenjia Wang (Spokane, Washington); Jaehyung Cho (Western Springs, Illinois); Asrar Malik (Hinsdale, Illinois) |
| ABSTRACT | Disclosed are nanoparticle compositions comprising nanoparticles prepared from denatured, cross-linked albumin and a therapeutic agent for treating a neutrophil-mediated inflammation, and methods of treating neutrophil-mediated inflammation using the compositions. |
| FILED | Monday, May 16, 2022 |
| APPL NO | 17/745567 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/1658 (20130101) A61K 9/5169 (20130101) A61K 31/05 (20130101) Original (OR) Class A61K 31/573 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5005 (20130101) G01N 2800/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230048960 | Daggett et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Valerie Daggett (Seattle, Washington); Dylan Shea (Seattle, Washington); Alissa Bleem (Seattle, Washington) |
| ABSTRACT | Alpha-sheet polypeptide multimers, and polypeptides for making multimers, compositions and medical devices including them, and their use for treating and diagnosing amyloid diseases or amyloid-associated diseases are disclosed. |
| FILED | Friday, May 20, 2022 |
| APPL NO | 17/749969 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/7007 (20130101) A61K 38/1787 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Peptides C07K 7/06 (20130101) C07K 7/08 (20130101) C07K 14/001 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230049066 | Zolotukhin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida); University of Massachusetts One Beacon Street (Boston, Massachusetts) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida); University of Massachusetts One Beacon Street (Boston, Florida) |
| INVENTOR(S) | Sergei Zolotukhin (Gainesville, Florida); Damien Marsic (Gainesville, Florida); Christian Murller (Concord, Massachusetts) |
| ABSTRACT | Disclosed herein are recombinant AAV variant (e.g., variant serotype 3B (AAV3B)) capsid proteins and variant capsid protein-containing viral particles with enhanced ability to transduce hepatic cells. Viral particles containing these capsid variants are capable of evading neutralization by the host humoral immune response. The recombinant AAV3B variant proteins and viral particles disclosed herein were identified from a variant AAV3B capsid library that was engineered by making substitutions in only the variable regions of the capsid. Some embodiments of the AAV3B capsid variants disclosed herein comprise the AAV3B-G3 variant and the AAV3B-E12 variant. Compositions of these variant AAV particles are provided that are useful for transducing and delivering therapeutic transgenes to cells, such as liver cells, and thus treat diseases and disorders pertaining to these cells. |
| FILED | Tuesday, November 24, 2020 |
| APPL NO | 17/779505 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 48/0025 (20130101) Original (OR) Class Peptides C07K 7/08 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2750/14122 (20130101) C12N 2750/14123 (20130101) C12N 2750/14142 (20130101) C12N 2750/14145 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230049180 | BACALLAO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Indiana University Research and Technology Corporation (Indianapolis, Indiana); United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | Indiana University Research and Technology Corporation (Indianapolis, Indiana); United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | Robert BACALLAO (Indianapolis, Indiana); Simon ATKINSON (Carmel, Indiana); George RHODES (Fishers, Indiana); Peter CORRIDON (Indianapolis, Indiana) |
| ABSTRACT | The present invention provides methods and materials useful delivering liquids, including liquids comprising nucleic acid molecules into cells. In particular, the present invention provides methods for delivering saline solution, exogenous compositions, and isolated vectors to kidney cells, using the renal vein as a guide and under hydrodynamic pressure. The delivery methods and materials herein are useful to research, prognose, ameliorate symptoms of kidney injury, and treat kidney pathologies. |
| FILED | Thursday, July 07, 2022 |
| APPL NO | 17/859470 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 38/45 (20130101) A61K 38/443 (20130101) A61K 48/0058 (20130101) A61K 48/0075 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2710/10041 (20130101) Enzymes C12Y 101/01042 (20130101) C12Y 208/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230049455 | Wolfe et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scot A. Wolfe (Winchester, Massachusetts); Pengpeng Liu (Worcester, Massachusetts); Kevin Luk (Worcester, Massachusetts) |
| ABSTRACT | RNA-guided programmable cytosine and adenine base editors are a powerful class of genome editing tool for the introduction of localized base transitions without generating a double-stranded DNA break. Base editors (BE) have an optimal window of activity relative to the PAM recognized by the Cas9 enzyme and these constructs are strand selective. Here we demonstrate that fusion of a programmable DNA-binding domain (pDBD) or another Cas9 orthologue to spCas9-BE, we can produce an RNA-programmable Cas9-BE-pDBD chimera or Cas9-BE-Cas9 chimeras with dramatically improved activities and increased targeting range. Cas9-pDBD or Cas9-Cas9 fusion base editors display an expanded targeting repertoire and achieve highly specific genome editing, which can be tailored to achieve extremely precise genome editing at nearly any genomic locus. |
| FILED | Friday, January 29, 2021 |
| APPL NO | 17/796184 |
| CURRENT CPC | Peptides C07K 14/195 (20130101) C07K 2319/81 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 9/78 (20130101) C12N 15/11 (20130101) C12N 15/62 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) Enzymes C12Y 305/04001 (20130101) C12Y 305/04002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230049468 | Alsubhi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Actuated Medical, Inc. (Bellefonte, Pennsylvania) |
| ASSIGNEE(S) | Actuated Medical, Inc. (Bellefonte, Pennsylvania) |
| INVENTOR(S) | Alanoud S Alsubhi (State College, Pennsylvania); Roger B Bagwell (Bellefonte, Pennsylvania); Jenna K Greaser (State College, Pennsylvania); Kevin A Snook (State College, Pennsylvania); Natasha A Tirko (State College, Pennsylvania); Kyle W Gheres (Pennsylvania Furnace, Pennsylvania); Ryan S Clement (State College, Pennsylvania) |
| ABSTRACT | A device for reducing foreign body response in a subject caused by an electrode implanted in a subject's tissue. A base is secured to the subject, having a base aperture in proximity to the target site. The base can receive and align a body thereon. A body contains a chamber extending between a chamber aperture, aligned with the base aperture, at one end and a chamber opening at an opposite end. The chamber contains an acoustic coupling medium, such as polyvinyl alcohol cryogel, transmits acoustic vibrations from a transducer without altering their frequency. The transducer is mounted to the device and is configured to transmit acoustic vibrations into the chamber and through said acoustic coupling medium to the subject tissue at the target site, creating an acoustic field in the target site sufficient to reduce foreign body response in the subject where the electrode contacts the target tissue. |
| FILED | Friday, June 10, 2022 |
| APPL NO | 17/837766 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0551 (20130101) A61N 7/00 (20130101) Original (OR) Class A61N 2007/0004 (20130101) Methods or Apparatus for Generating or Transmitting Mechanical Vibrations of Infrasonic, Sonic, or Ultrasonic Frequency, for Performing Mechanical Work in General B06B 1/0655 (20130101) B06B 2201/76 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230049525 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United states of American, as Representative by the Secretary, Dept.of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kun Wang (Bethesda, Maryland); Sushant Patkar (Bethesda, Maryland); Joo Sang Lee (Bethesda, Maryland); Eytan Ruppin (Bethesda, Maryland); Alejandro Schaffer (Bethesda, Maryland) |
| ABSTRACT | Provided herein are methods of identifying gene expression levels in specific cell types based on bulk gene expression levels measured in tissue samples comprising a plurality of cell types. |
| FILED | Wednesday, November 25, 2020 |
| APPL NO | 17/780356 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/20 (20190201) G16B 25/10 (20190201) Original (OR) Class G16B 35/20 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230049737 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| INVENTOR(S) | Feng Zhang (Cambridge, Massachusetts); Jonathan Strecker (Cambridge, Massachusetts); David Li (Cambridge, Massachusetts) |
| ABSTRACT | Systems and methods for targeted gene modification, targeted insertion, perturbation of gene transcripts, and nucleic acid editing. Novel nucleic acid targeting systems comprise components of CRISPR systems, reverse transcriptase, pegRNAs, paired pegRNAs or modified pegRNAs, DNA processing proteins, recombinases, proteins for inhibiting nucleases, and proteins for promoting ssDNA annealing. |
| FILED | Wednesday, December 30, 2020 |
| APPL NO | 17/786168 |
| CURRENT CPC | Peptides C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/1276 (20130101) C12N 15/90 (20130101) Original (OR) Class C12N 2310/20 (20170501) Enzymes C12Y 301/01 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230049954 | PUIG-SAUS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Cristina PUIG-SAUS (Los Angeles, California); Antoni RIBAS (Los Angeles, California); Yvonne CHEN (Los Angeles, California) |
| ABSTRACT | Methods and compositions are provided related to therapeutic receptors, including chimeric antigen receptors (CARs), capable of specifically binding TYRP-1. The disclosed compositions include, for example, cells (e.g., immune cells) expressing TYRP-1 specific CARs, nucleic acids encoding TYRP-1 specific CARs, and TYRP-1 specific CAR polypeptides. Certain aspects relate to methods of treating cancer, including melanoma, using compositions comprising TYRP-1 specific CARs, for example cells expressing TYRP-1 specific CARs. In some embodiments, provided herein are chimeric polypeptides comprising a TYRP-1 binding domain, a hinge region, a transmembrane domain, and an intracellular signaling domain. |
| FILED | Friday, September 04, 2020 |
| APPL NO | 17/640281 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/00 (20180101) A61P 35/00 (20180101) Peptides C07K 14/7051 (20130101) C07K 14/70521 (20130101) C07K 14/70578 (20130101) C07K 14/70596 (20130101) C07K 16/2803 (20130101) C07K 2317/53 (20130101) C07K 2317/524 (20130101) C07K 2317/526 (20130101) C07K 2319/02 (20130101) C07K 2319/03 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230050006 | Pickerill et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | REHABILITATION INSTITUTE OF CHICAGO D/B/A SHIRLEY RYAN ABILITYLAB (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tom Pickerill (Chicago, Illinois); James Lipsey (Chicago, Illinois) |
| ABSTRACT | An assistive device is disclosed that includes a plurality of control systems for controlling active and passive tasks. The assistive device accommodates active power generation when needed, but is otherwise configured to switch to passive control for other tasks. The assistive device further includes a continuously variable transmission to optimize movement of the assistive device for a variety of tasks. The assistive device includes a lower limb embodiment defining an artificial knee joint controlled by the plurality of control systems. |
| FILED | Monday, December 07, 2020 |
| APPL NO | 17/756368 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/64 (20130101) A61F 2/70 (20130101) Original (OR) Class A61F 2/5044 (20130101) A61F 2002/701 (20130101) A61F 2002/704 (20130101) A61F 2002/7625 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 40/63 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230050022 | Pun et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington); Seattle Children's Hospital d/b/a Seattle Children's Research Institute (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington); Seattle Children's Hospital d/b/a Seattle Children's Research Institute (Seattle, Washington) |
| INVENTOR(S) | Suzie Hwang Pun (Seattle, Washington); Nataly Kacherovsky (Seattle, Washington); Emmeline Cheng (Seattle, Washington); Ian Cardle (Seattle, Washington); Michael Jensen (Seattle, Washington) |
| ABSTRACT | Described herein are aptamers that bind to the transferrin receptor (e.g., CD71) and can be used, in part, for depleting transferrin receptor-expressing cells from a population of therapeutic cells. These aptamer compositions can be used in methods for isolating and/or enriching cells expressing CD71 or depleting cell populations of cells expressing CD71, including for example, tumor cells. Further provided are methods of using the aptamers or cell populations generated using them in the methods disclosed herein for therapies and/or drug delivery. |
| FILED | Friday, July 15, 2022 |
| APPL NO | 17/813021 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 47/549 (20170801) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0093 (20130101) Original (OR) Class C12N 15/115 (20130101) C12N 2310/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230050231 | Kern et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Brandeis University (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dorothee Kern (Waltham, Massachusetts); Adelajda Zorba (Waltham, Massachusetts) |
| ABSTRACT | The present invention features an antibody mimetic, or an antigen binding fragment thereof, that specifically binds to an allosteric site of Aurora A kinase, therapeutic compositions comprising this antibody mimetic, and the use of the monobody to modulate Aurora A kinase for the treatment of cancer. |
| FILED | Tuesday, July 20, 2021 |
| APPL NO | 17/380704 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5008 (20130101) Original (OR) Class G01N 2333/47 (20130101) G01N 2333/91205 (20130101) G01N 2500/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230050306 | Anderson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Daniel G. Anderson (Framingham, Massachusetts); Robert Alexander Wesselhoeft (Boston, Massachusetts); Piotr S. Kowalski (Cork, Ireland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel G. Anderson (Framingham, Massachusetts); Robert Alexander Wesselhoeft (Boston, Massachusetts); Piotr S. Kowalski (Cork, Ireland) |
| ABSTRACT | Methods and constructs for engineering circular RNA are disclosed. In some embodiments, the methods and constructs comprise a vector for making circular RNA, the vector comprising the following elements operably connected to each other and arranged in the following sequence: a.) a 5′ homology arm, b.) a 3′ group I intron fragment containing a 3′ splice site dinucleotide, c.) optionally, a 5′ spacer sequence, d.) a protein coding or noncoding region, e.) optionally, a 3′ spacer sequence, f) a 5′ Group I intron fragment containing a 5′ splice site dinucleotide, and g.) a 3′ homology arm, the vector allowing production of a circular RNA that is translatable or biologically active inside eukaryotic cells. Methods for purifying the circular RNA produced by the vector and the use of nucleoside modifications in circular RNA produced by the vector are also disclosed. |
| FILED | Tuesday, August 23, 2022 |
| APPL NO | 17/894141 |
| CURRENT CPC | Peptides C07K 16/2803 (20130101) C07K 2317/31 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) C12N 15/85 (20130101) Original (OR) Class C12N 2015/859 (20130101) C12N 2015/8518 (20130101) C12N 2800/70 (20130101) C12N 2800/107 (20130101) C12N 2800/202 (20130101) C12N 2840/55 (20130101) C12N 2840/60 (20130101) C12N 2840/203 (20130101) C12N 2999/007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230050339 | Shivakumar |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Children's Hospital Medical Center (Cincinnati, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pranav-Kumar Shivakumar (Cincinnati, Ohio) |
| ABSTRACT | Disclosed are methods of treating an individual, for example, a human individual, or more particularly a pediatric individual, having a disease characterized by liver fibrosis, comprising administering a therapeutically effective amount of one or both of a Complement Factor B inhibitor and a Complement Factor P (“CFP” or “properdin”) inhibitor, e.g., anti-CFP antibody and/or anti-CFB antibody or the respective antigen-binding fragment(s) thereof. Exemplary disease states include, but are not limited to, biliary atresia and post-Kasai biliary atresia. |
| FILED | Wednesday, February 17, 2021 |
| APPL NO | 17/796796 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/19 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) A61P 29/00 (20180101) Peptides C07K 16/18 (20130101) Original (OR) Class C07K 16/40 (20130101) C07K 2317/76 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230050394 | ULRICH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States, as Represented by The Secretary of The Army (Fort Detrick, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert G. ULRICH (Frederick, Maryland); Teddy KAMATA (Frederick, Maryland) |
| ABSTRACT | The disclosure relates to compositions, assays, methods and kits comprising one or more amino acid sequences of a filovirus protein, or a fragment thereof, which find use in the detection of a filovirus infection and/or the presence of antibodies specific for a filovirus in a biological sample. |
| FILED | Monday, August 08, 2022 |
| APPL NO | 17/883189 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) G01N 2333/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230050416 | Kochenderfer |
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| FUNDED BY |
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| APPLICANT(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | James N. Kochenderfer (Bethesda, Maryland) |
| ABSTRACT | The invention provides an isolated and purified nucleic acid sequence encoding a chimeric antigen receptor (CAR) directed against B-cell Maturation Antigen (BCMA). The invention also provides host cells, such as T-cells or natural killer (NK) cells, expressing the CAR and methods for destroying multiple myeloma cells. |
| FILED | Thursday, October 06, 2022 |
| APPL NO | 17/938529 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Peptides C07K 14/7051 (20130101) C07K 14/70503 (20130101) C07K 14/70517 (20130101) C07K 14/70521 (20130101) C07K 14/70578 (20130101) C07K 16/18 (20130101) C07K 16/2878 (20130101) C07K 2317/73 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/62 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230050584 | Kobayashi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The USA, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The USA, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Hisataka Kobayashi (Laurel, Maryland); Peter Choyke (Rockville, Maryland) |
| ABSTRACT | The present disclosure relates to compositions and methods of killing cells. In particular examples, the method includes contacting a cell having a cell surface protein with a therapeutically effective amount of an antibody-IR700 molecule, wherein the antibody specifically binds to the cell surface protein, such as a tumor-specific antigen on the surface of a tumor cell. The cell is subsequently irradiated, such as at a wavelength of 660 to 740 nm at a dose of at least 1 J cm−2. The cell is also contacted with one or more therapeutic agents (such as an anti-cancer agent), for example about 0 to 8 hours after irradiating the cell, thereby killing the cell. Also provided are methods of imaging cell killing in real time, using fluorescence lifetime imaging. Also provided are wearable devices that include an article of clothing, jewelry, or covering; and an NIR LED incorporated into the article, which can be used with the disclosed methods. |
| FILED | Wednesday, June 15, 2022 |
| APPL NO | 17/841110 |
| CURRENT CPC | Personal Adornments, e.g Jewellery; Coins A44C 15/00 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/704 (20130101) A61K 41/0071 (20130101) A61K 45/06 (20130101) Original (OR) Class A61K 47/6803 (20170801) A61K 47/6869 (20170801) A61K 49/0032 (20130101) A61K 49/0058 (20130101) Peptides C07K 16/30 (20130101) C07K 16/32 (20130101) C07K 16/2863 (20130101) C07K 16/3069 (20130101) C07K 2317/77 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5011 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230050594 | Dosenbach et al. |
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| FUNDED BY |
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| APPLICANT(S) | Nico Dosenbach (St. Louis, Missouri); Chad Sylvester (St. Louis, Missouri); Deanna Greene (St. Louis, Missouri); Scott Marek (St. Louis, Missouri); Scott Norris (St. Louis, Missouri); Jarod Roland (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Nico Dosenbach (St. Louis, Missouri); Chad Sylvester (St. Louis, Missouri); Deanna Greene (St. Louis, Missouri); Scott Marek (St. Louis, Missouri); Scott Norris (St. Louis, Missouri); Jarod Roland (St. Louis, Missouri) |
| ABSTRACT | A method of performing personalized neuromodulation on a subject is provided. The method includes acquiring functional magnetic resonance imaging (fMRI) data of a brain of the subject. The method also includes calculating functional connectivity of the brain between a voxel in a subcortical region of the brain and a voxel in a cortical region of the brain, based on the fMRI data. The method also includes identifying a target location in the brain to be targeted by neuromodulation based on the calculated functional connectivity. |
| FILED | Wednesday, September 21, 2022 |
| APPL NO | 17/933896 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0036 (20180801) A61B 5/0042 (20130101) A61B 5/055 (20130101) A61B 5/4064 (20130101) A61B 2576/026 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/3727 (20130101) A61N 1/36189 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/4806 (20130101) Original (OR) Class G01R 33/56366 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230050649 | Thorpe et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia); Virginia Tech Intellectual Properties, Inc. (Blacksburg, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven Brandon Thorpe (Palmyra, Virginia); Webster L. Santos (Blacksburg, Virginia); Kevin R. Lynch (Charlottesville, Virginia) |
| ABSTRACT | Sphingosine kinases are enzymes that catalyze the biosynthesis of sphingosine-1-phosphate. The invention provides prodrugs of compounds that are effective for inhibition of sphingosine kinase type 1, sphingosine kinase type 2, or both, according to formula (I) as described herein. Formula I compounds are useful in the treatment of a range of diseases wherein increasing the level of sphingosine-1-phosphate in blood is medically indicated. The invention also provides pharmaceutical compositions of Formula I compounds. |
| FILED | Wednesday, July 14, 2021 |
| APPL NO | 17/305773 |
| CURRENT CPC | Heterocyclic Compounds C07D 413/04 (20130101) C07D 413/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230050861 | Ingbar et al. |
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| FUNDED BY |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David H. Ingbar (Minneapolis, Minnesota); Timothy P. Rich (Duluth, Minnesota); Robert J. Schumacher (Edina, Minnesota); Jianxun Lei (New Brighton, Minnesota); Maneesh Bhargava (Mendota Heights, Minnesota) |
| ABSTRACT | A pharmaceutical composition for administering directly to the pulmonary tract of a subject includes a salt of triiodothyronine and a pharmaceutically acceptable buffer, adjusted to a pH of 5.5-8.5. The composition can be administered prophylactically or therapeutically to a subject to treat lung inflammation or pulmonary edema. |
| FILED | Tuesday, August 23, 2022 |
| APPL NO | 17/893612 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0078 (20130101) Original (OR) Class A61K 31/198 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230050982 | del Alamo de Pedro et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (5th Floor, California); Fundacion para la Investigacion Biomedica del Hospital Gregorio Marano (Madrid, Spain) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Juan Carlos del Alamo de Pedro (San Diego, California); Lorenzo Rossini (San Diego, California); Andrew Kahn (San Diego, California); Javier Bermejo (Madrid, Spain); Pablo Martínez-Legazpi (Madrid, Spain); Raquel Yotti Alvarez (Madrid, Spain) |
| ABSTRACT | Provided herein are methods for in-vivo assessment of intraventricular flow shear stress, risk of hemolysis, also the location and extent of blood flow stasis regions and inside a cardiac chamber or blood vessel. Also provided herein are systems for performing such methods. Also provided herein are methods for assessing hemolysis and/or thrombosis risk in patients implanted with an LVAD. LVAD positioning and/or speed may be adjusted based on the results obtained by using methods described herein, and the risk for hemolysis and/or thrombosis can be minimized. |
| FILED | Wednesday, September 28, 2022 |
| APPL NO | 17/955077 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/0263 (20130101) A61B 5/0285 (20130101) A61B 5/02035 (20130101) A61B 5/4851 (20130101) Original (OR) Class A61B 5/7225 (20130101) A61B 8/065 (20130101) A61B 8/485 (20130101) A61B 8/488 (20130101) A61B 8/0883 (20130101) A61B 8/5223 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 60/178 (20210101) A61M 60/857 (20210101) A61M 2205/04 (20130101) A61M 2250/00 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101) G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230051277 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peiran Zhang (Durham, North Carolina); Joseph Rufo (Durham, North Carolina); Tony Jun Huang (Durham, North Carolina) |
| ABSTRACT | Technologies for acoustoelectronic manipulation of micro/nano particles include a system having a piezoelectric substrate coupled to one or more acoustic transducers and a fluid layer positioned above the substrate. Micro/nano particles are introduced to the fluid, which can be in the form of a droplet or in a confined channel, and a signal is applied to the acoustic transducer. One or more parameters of the signal are varied after introducing the micro/nano particles into the fluid. The parameters may include amplitude, frequency, or phase of the signal. The system may include one or more acoustic transducers. Multiple signals may be applied to the acoustic transducers. Wave superposition of acoustic waves in the substrate manipulates micro/nano particles in the fluid. The nanoparticles may include carbon nanotubes, nanowires, nanofibers, graphene flakes, quantum dots, SERS probes, exosomes, vesicles, DNA, RNA, antibodies, antigens, macromolecules, or proteins. |
| FILED | Tuesday, August 09, 2022 |
| APPL NO | 17/883883 |
| CURRENT CPC | Methods or Apparatus for Generating or Transmitting Mechanical Vibrations of Infrasonic, Sonic, or Ultrasonic Frequency, for Performing Mechanical Work in General B06B 1/0607 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 41/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230051453 | Tang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yi Tang (Arcadia, California); Mengbin Chen (Los Angeles, California); Ikechukwu Okorafor (Los Angeles, California) |
| ABSTRACT | The disclosure provides biosynthetic platforms that generate olivetolic acid and its analogues at high titers from microbes, and in cell free systems. |
| FILED | Saturday, January 09, 2021 |
| APPL NO | 17/791854 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/16 (20130101) C12N 9/93 (20130101) C12N 15/815 (20130101) C12N 2800/102 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/22 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230051627 | DAI et al. |
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| FUNDED BY |
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| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Mingjie DAI (Cambridge, Massachusetts); George M. CHURCH (Cambridge, Massachusetts); Marc W. KIRSCHNER (Cambridge, Massachusetts) |
| ABSTRACT | The technology described herein is directed to methods for obtaining partial sequence information from a target protein. Also described herein are systems, devices, and kits for obtaining partial sequence information from a target protein. |
| FILED | Monday, August 01, 2022 |
| APPL NO | 17/878534 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6818 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230051644 | SABATINI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Whitehead Institute for Biomedical Research (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David M. SABATINI (Cambridge, Massachusetts); Jason Cantor (Madison, Wisconsin) |
| ABSTRACT | In some aspects, described herein are cell culture media that are useful for in vitro culture of mammalian cells. The culture media contain a variety of small organic compounds that are found in normal adult human blood. Also described are methods of using the culture media for a variety of purposes. Also described are methods of treating cancer. |
| FILED | Thursday, August 04, 2022 |
| APPL NO | 17/881200 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 41/32 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0018 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230051690 | Chadli |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Augusta University Research Institute, Inc. (Augusta, Georgia) |
| ASSIGNEE(S) | Augusta University Research Institute, Inc. (Augusta, Georgia) |
| INVENTOR(S) | Ahmed Chadli (Evans, Georgia) |
| ABSTRACT | It has been discovered that the cyclic peptide EnnA inactivates the Hsp90 chaperone pathway, but without activating an extensive heat shock response and overexpression of anti-apoptotic proteins. Mechanistically distinct, EnnA inhibits Hsp90 and destabilize PDL-1 and IDO, two major immune checkpoints mediating tumor-induced immune suppression. The provided herein show that EnnA profoundly modulates the cytokine signature of cancer cells and promotes a cytokine profile that favors an immune attack on tumor cells. This translates into highly efficacious anti-tumor activity in vivo, which, when combined with a single dose of chemotherapy, completely reduced the tumor burden in experimental animals and instilled highly efficient immune memory against the primary tumor. |
| FILED | Monday, September 19, 2022 |
| APPL NO | 17/933276 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/664 (20130101) A61K 38/12 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230051847 | Vogelstein et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bert Vogelstein (Baltimore, Maryland); Kenneth W. Kinzler (Baltimore, Maryland); Emily Han-Chung Hsiue (Baltimore, Maryland); Jacqueline Douglass (Baltimore, Maryland); Michael S. Hwang (Seattle, Washington); Alexander Pearlman (Baltimore, Maryland); Nickolas Papadopoulos (Towson, Maryland); Shibin Zhou (Owings Mills, Maryland); Brian Mog (Baltimore, Maryland); Katharine M. Wright (Baltimore, Maryland); Sandra B. Gabelli (Ellicott City, Maryland) |
| ABSTRACT | This document provides methods and materials for assessing a mammal having or suspected of having cancer and/or for treating a mammal having cancer. For example, molecules including one or more antigen-binding domains (e.g., a single-chain variable fragment (scFv)) that can bind to a modified peptide (e.g., a tumor antigen), as well as method for using such molecules, are provided. |
| FILED | Thursday, December 17, 2020 |
| APPL NO | 17/783506 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/30 (20130101) Original (OR) Class C07K 16/2809 (20130101) C07K 2317/24 (20130101) C07K 2317/622 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230051989 | Wu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chia-Yung Wu (San Francisco, California); James Onuffer (Alameda, California); Wendell A. Lim (San Francisco, California) |
| ABSTRACT | The present disclosure provides a heterodimeric, conditionally active chimeric antigen receptor (CAR), and a nucleic acid comprising a nucleotide sequence encoding the CAR. The present disclosure provides cells genetically modified to produce the CAR. A CAR of the present disclosure can be used in various methods, which are also provided. |
| FILED | Wednesday, September 14, 2022 |
| APPL NO | 17/932259 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 47/6891 (20170801) A61K 2039/505 (20130101) Peptides C07K 14/705 (20130101) C07K 14/7051 (20130101) C07K 14/70521 (20130101) C07K 14/70575 (20130101) C07K 14/70578 (20130101) C07K 16/18 (20130101) C07K 16/2803 (20130101) C07K 16/2866 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 9/14 (20130101) C12N 9/90 (20130101) Enzymes C12Y 502/01008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230052009 | Kariko et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Katalin Kariko (Rydal, Pennsylvania); Drew Weissman (Wynnewood, Pennsylvania) |
| ABSTRACT | This invention provides RNA, oligoribonucleotide, and polyribonucleotide molecules comprising pseudouridine or a modified nucleoside, gene therapy vectors comprising same, methods of synthesizing same, and methods for gene replacement, gene therapy, gene transcription silencing, and the delivery of therapeutic proteins to tissue in vivo, comprising the molecules. The present invention also provides methods of reducing the immunogenicity of RNA, oligoribonucleotide, and polyribonucleotide molecules. |
| FILED | Wednesday, June 15, 2022 |
| APPL NO | 17/840967 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/50 (20130101) A61K 38/177 (20130101) A61K 38/1816 (20130101) A61K 48/00 (20130101) A61K 48/005 (20130101) A61K 48/0041 (20130101) A61K 48/0066 (20130101) Original (OR) Class A61K 48/0075 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/02 (20130101) Peptides C07K 14/47 (20130101) C07K 14/505 (20130101) C07K 14/4712 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0602 (20130101) C12N 5/0696 (20130101) C12N 15/67 (20130101) C12N 15/85 (20130101) C12N 15/117 (20130101) C12N 2310/17 (20130101) C12N 2310/33 (20130101) C12N 2310/3341 (20130101) C12N 2501/40 (20130101) C12N 2800/95 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) Enzymes C12Y 305/04004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230052280 | Martin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jack Anthony Martin (Madison, Wisconsin); Darryl Gerard Thelen (Madison, Wisconsin) |
| ABSTRACT | Measurement of an induced shear wave in tensioned tissue of a given individual is provided to a machine learning system trained to determine absolute load from shear wave signal data. The machine learning system uses a teaching set linking shear wave signal data to absolute load, however, does not require normal calibration data based on measured loads allowing reduced or no calibration for absolute load determinations. |
| FILED | Monday, July 11, 2022 |
| APPL NO | 17/811640 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0057 (20130101) Original (OR) Class A61B 5/4523 (20130101) A61B 2562/0219 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230052289 | Bau et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Haim H. Bau (Swarthmore, Pennsylvania); Jinzhao Song (Philadelphia, Pennsylvania); Junman Chen (Philadelphia, Pennsylvania) |
| ABSTRACT | Described is an assay termed Programmable Enzyme-Assisted Selective Exponential Amplification (PASEA) that concurrently amplifies both wild type and mutant alleles while selectively cleaving the former. With time, the rare mutant alleles dominate, and are readily detectable by direct detection, Sanger sequencing, and other readily available methods. Also described are point-of-care assays and microfluidic devices for performing PASEA. |
| FILED | Friday, July 22, 2022 |
| APPL NO | 17/871702 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/102 (20130101) C12N 15/902 (20130101) Original (OR) Class C12N 2310/20 (20170501) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/542 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230052528 | Arkin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); WASHINGTON UNIVERSITY IN ST. LOUIS (St. Louis, Missouri); VANDERBILT UNIVERSITY (Nashville, Tennessee); SRI INTERNATIONAL (Menlo Park, California); The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michelle R. Arkin (San Francisco, California); R. Jeffrey Neitz (San Francisco, California); Adam R. Renslo (Oakland, California); James Hsieh (Englewood Cliffs, New Jersey); Shubhankar Dutta (San Francisco, California); Clifford Bryant (Millbrae, California); William J. Moore (Hagerstown, Maryland); Alex G. Waterson (Murfreesboro, Tennessee); Lidia Sambucetti (Redwood City, California); Somnath Jana (Nashville, Tennessee); lan M. Romaine (Nashville, Tennessee); Alexander P. Lamers (Nashville, Tennessee); Yassir Younis Adam (San Francisco, California); Claire Repellin (Menlo Park, California) |
| ABSTRACT | Disclosed herein, inter alia, are compounds and methods for inhibiting Taspase1 and the treatment of cancer. |
| FILED | Friday, November 20, 2020 |
| APPL NO | 17/777971 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) A61P 35/00 (20180101) Acyclic or Carbocyclic Compounds C07C 311/11 (20130101) C07C 323/41 (20130101) Heterocyclic Compounds C07D 241/04 (20130101) Original (OR) Class C07D 295/26 (20130101) C07D 403/12 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/6421 (20130101) Enzymes C12Y 304/25 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230052675 | Seidel, III et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Albert Einstein College of Medicine (Bronx, New York) |
| ASSIGNEE(S) | Albert Einstein College of Medicine (Bronx, New York) |
| INVENTOR(S) | Ronald D. Seidel, III (Bronx, New York); Rodolfo J. Chaparro (Bronx, New York); Brandan S. Hillerich (Ithaca, New York); Steven C. Almo (Pelham, New York) |
| ABSTRACT | Methods and systems for the efficient and systematic identification of the repertoire of T-cell epitopes. |
| FILED | Friday, May 27, 2022 |
| APPL NO | 17/827024 |
| CURRENT CPC | Peptides C07K 14/70539 (20130101) C07K 2319/03 (20130101) C07K 2319/30 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6881 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56972 (20130101) Original (OR) Class G01N 2333/15 (20130101) G01N 2333/155 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230052740 | Shoichet et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina); The Research Foundation for the State University of New York (Amherst, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian K. Shoichet (San Francisco, California); Reed M. Stein (San Francisco, California); Margarita L. Dubocovich (Clarence, New York); Grant C. Glatfelter (Baltimore, Maryland); Bryan L. Roth (Durham, North Carolina); Hye Jin Kang (Chapel HIll, North Carolina) |
| ABSTRACT | Disclosed herein are, inter alia, compounds modulating MT1 and MT2 receptors' activity and methods of use thereof for treating MT1 and MT2 receptor-related conditions. |
| FILED | Thursday, August 27, 2020 |
| APPL NO | 17/638172 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/435 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230053013 | Han et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gang Han (Shrewsbury, Massachusetts); Yubin Zhou (Bellaire, Texas) |
| ABSTRACT | The invention provides novel light-switchable CAR T-cells that can be remotely controlled through NIR-light-converting upconvension nanoparticles, and related CAR T constructs, nanoparticles, compositions and methods thereof for optogenetic therapy. |
| FILED | Tuesday, November 24, 2020 |
| APPL NO | 17/777363 |
| CURRENT CPC | Peptides C07K 14/7051 (20130101) Original (OR) Class C07K 14/70517 (20130101) C07K 14/70578 (20130101) C07K 16/2803 (20130101) C07K 2317/622 (20130101) C07K 2319/02 (20130101) C07K 2319/03 (20130101) C07K 2319/70 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230053219 | OLSON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Regents of The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | The Board of Regents of The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Eric OLSON (Dallas, Texas); Douglas P. MILLAY (Frisco, Texas) |
| ABSTRACT | The present disclosure describes the fusogenic activity of the Myomaker protein. This polypeptide, when expressed in non-muscle cells, is able to drive fusion of the cell with a muscle cell, but not with other non-muscle cells. The use of this protein and cell expressing it in the delivery of exogenous genetic material to muscle cells also is described. |
| FILED | Friday, September 30, 2022 |
| APPL NO | 17/937047 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 38/1719 (20130101) Original (OR) Class A61K 45/06 (20130101) Peptides C07K 14/4716 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/16 (20130101) C12N 15/02 (20130101) C12N 2740/10043 (20130101) C12N 2740/10071 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230053327 | MacEwan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew R. MacEwan (St. Louis, Missouri); Jingwei Xie (St. Louis, Missouri); Zack Ray (St. Louis, Missouri); Younan Xia (St. Louis, Missouri) |
| ABSTRACT | A multi-laminar electrospun nanofiber scaffold for use in repairing a defect in a tissue substrate is provided. The scaffold includes a first layer formed by a first plurality of electrospun polymeric fibers, and a second layer formed by a second plurality of electrospun polymeric fibers. The second layer is combined with the first layer. A first portion of the scaffold includes a higher density of fibers than a second portion of the scaffold, and the first portion has a higher tensile strength than the second portion. The scaffold is configured to degrade via hydrolysis after at least one of a predetermined time or an environmental condition. The scaffold is configured to be applied to the tissue substrate containing the defect, and is sufficiently flexible to facilitate application of the scaffold to uneven surfaces of the tissue substrate, and to enable movement of the scaffold by the tissue substrate. |
| FILED | Friday, June 25, 2021 |
| APPL NO | 17/358463 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/02 (20130101) Original (OR) Class A61F 2/0063 (20130101) A61F 2/105 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 15/22 (20130101) A61L 15/42 (20130101) A61L 27/14 (20130101) A61L 27/50 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 48/05 (20190201) B29C 48/142 (20190201) Apparatus for Enzymology or Microbiology; C12M 25/14 (20130101) Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/0076 (20130101) D01D 5/0092 (20130101) Making Textile Fabrics, e.g From Fibres or Filamentary Material; Fabrics Made by Such Processes or Apparatus, e.g Felts, Non-woven Fabrics; Cotton-wool; Wadding D04H 1/728 (20130101) D04H 3/016 (20130101) D04H 3/073 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20230045804 | Salahuddin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sayeef Salahuddin (Walnut Creek, California); Shehrin Sayed (Berkeley, California) |
| ABSTRACT | The present disclosure relates to a magnetic memory structure with a voltage-controlled gain-cell configuration, which includes a memory resistive device, a first transistor connected in series with the memory resistive device, and a second transistor. The memory resistive device has a baseline resistance larger than 10 MΩ, and is eligible to exhibit a ‘1’ state and a ‘0’ state and exhibit a resistance change between the ‘1’ state and the ‘0’ state. The second transistor has a gate connected to a connection node of the first transistor and the memory resistive device. When the memory resistive device exhibits the ‘1’ state, a gate voltage for the second transistor is smaller than a threshold voltage of the second transistor, and when the memory resistive device exhibits the ‘0’ state, the gate voltage for the second transistor is larger than the threshold voltage of the second transistor. |
| FILED | Wednesday, August 11, 2021 |
| APPL NO | 17/399583 |
| CURRENT CPC | Static Stores G11C 11/161 (20130101) Original (OR) Class G11C 11/1655 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/228 (20130101) H01L 43/02 (20130101) H01L 43/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230045818 | Glavin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas R. Glavin (Springboro, Ohio); Christopher Muratore (Kettering, Ohio) |
| ABSTRACT | A process of making sensors and sensor arrays that has the ability to manipulate of the morphology or flow of an applied drop or sample over the sensor array surface at any point in the patterning process and sensors and sensor arrays having increased sensitivity and limits of detection. In addition, said process can provided real time notification of any centerline deviation. Such production process can be adjusted in real time. Thus, large numbers of units can be made—even in millions of per day—with few if any out of specification units being produced. Such process does not require large-scale clean rooms and is easily configurable. |
| FILED | Friday, September 30, 2022 |
| APPL NO | 17/957293 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/02422 (20130101) H01L 21/02488 (20130101) H01L 21/02491 (20130101) H01L 21/02505 (20130101) H01L 21/02683 (20130101) H01L 21/02686 (20130101) Original (OR) Class H01L 29/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230045938 | CAROLAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Jacques Johannes CAROLAN (Cambridge, Massachusetts); Mihika PRABHU (Cambridge, Massachusetts); Scott A. SKIRLO (Boston, Massachusetts); Yichen Shen (Cambridge, Massachusetts); Marin SOLJACIC (Belmont, Massachusetts); DIRK ENGLUND (Brookline, Massachusetts); Nicholas C. HARRIS (Boston, Massachusetts) |
| ABSTRACT | An optical neural network is constructed based on photonic integrated circuits to perform neuromorphic computing. In the optical neural network, matrix multiplication is implemented using one or more optical interference units, which can apply an arbitrary weighting matrix multiplication to an array of input optical signals. Nonlinear activation is realized by an optical nonlinearity unit, which can be based on nonlinear optical effects, such as saturable absorption. These calculations are implemented optically, thereby resulting in high calculation speeds and low power consumption in the optical neural network. |
| FILED | Wednesday, May 04, 2022 |
| APPL NO | 17/736667 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/212 (20210101) G02F 1/225 (20130101) G02F 1/365 (20130101) G02F 1/3526 (20130101) G02F 3/024 (20130101) Optical Computing Devices; G06E 3/005 (20130101) Original (OR) Class G06E 3/006 (20130101) G06E 3/008 (20130101) Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/08 (20130101) G06N 3/084 (20130101) G06N 3/0675 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230046027 | Godfrey et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Bruce J. Godfrey (Seattle, Washington); Mari-Karoliina Henriikka Winkler (Seattle, Washington); David Stahl (Seattle, Washington) |
| ABSTRACT | The present disclosure describes a microorganism support structure, including a gas-permeable layer comprising two opposing surfaces; a microorganism adhesive coats at least one surface of the gas-permeable layer; and a microorganism disposed on the microorganism adhesive-coated surface of the layer. The microorganism adhesive enhances the adhesion of the microorganism on the layer compared to a gas-permeable layer that does not have the microorganism adhesive. |
| FILED | Tuesday, January 12, 2021 |
| APPL NO | 17/791676 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 3/307 (20130101) C02F 3/341 (20130101) C02F 3/348 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 11/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230046323 | Keyser |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christian Keyser (Shalimar, Florida) |
| ABSTRACT | Systems and methods for three-dimensional (3-D) imaging enabled by natural range-dependent processes. Multiple lasers are configured to independently flash illuminate a target object to 3- D image a resultant “scene” onto a focal plane array (FPA). The first laser produces a wavelength non-resonant with an atmospheric absorption line along the illumination path. The second laser produces a wavelength resonant with the atmospheric absorption line, and closely spaced with the non-resonant wavelength. A ratio of the respective intensities recorded at the FPA for the two wavelengths calculates a range to the target object. |
| FILED | Monday, October 03, 2022 |
| APPL NO | 17/937647 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/484 (20130101) G01S 7/486 (20130101) G01S 17/42 (20130101) G01S 17/89 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230046545 | Van Hook et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Richard Van Hook (Xenia, Ohio); Russell Hardie (Centerville, Ohio) |
| ASSIGNEE(S) | Government of the United States as represented by the Secretary of the Air Force (Wright Patterson AFB, Ohio) |
| INVENTOR(S) | Richard Van Hook (Xenia, Ohio); Russell Hardie (Centerville, Ohio) |
| ABSTRACT | A method for determining the likelihood that a pixel in a video image sequence represents true motion in the image. Light from a scene is captured to yield an original image having a sequence of frames. A prototype image is created from the original image as a geometrically accurate representation of the scene which is substantially free of contamination. A tilt variance-Gaussian mixture model and/or multi-variate Gaussian model, based upon optical turbulence statistics associated with the scene, is developed. Each pixel in the original image sequence of frames is evaluated against the prototype image using a probability density function, to yield a likelihood that the respective pixel represents true motion. |
| FILED | Saturday, July 09, 2022 |
| APPL NO | 17/861171 |
| CURRENT CPC | Pictorial Communication, e.g Television H04N 5/23261 (20130101) Original (OR) Class H04N 5/23277 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230046768 | NARASIMHAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania); WILLIAM MARSH RICE UNIVERSITY (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Srinivasa NARASIMHAN (Pittsburgh, Pennsylvania); Chao LIU (Pittsburgh, Pennsylvania); Ashutosh SABHARWAL (Houston, Texas); Akash K. MAITY (Houston, Texas); Artur DUBRAWSKI (Pittsburgh, Pennsylvania) |
| ABSTRACT | A fast imaging apparatus and method for high resolution diffuse optical tomography with a line imaging and illumination system is disclosed. The method uses an algorithm comprising a convolution approximation of the forward heterogeneous scattering model that can be inverted to produce deeper than ever before structured beneath the surface. The method can detect reasonably accurate boundaries and relative depth of absorption variations up to a depth of approximately 8 mm below highly scattering medium such as skin. |
| FILED | Wednesday, April 21, 2021 |
| APPL NO | 17/631905 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0073 (20130101) Original (OR) Class A61B 5/0077 (20130101) A61B 2562/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230046840 | Ramanathan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ObjectVideo Labs, LLC (Tysons, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Narayanan Ramanathan (Chantilly, Virginia); Allison Beach (Leesburg, Virginia); Robert S. Hastings (Tysons, Virginia); Weihong Yin (Great Falls, Virginia); Sima Taheri (McLean, Virginia); Dana Eubanks (Herndon, Virginia); Kyoung-Jin Park (Ellicott City, Maryland); Donald Gerard Madden (Columbia, Maryland); Gang Qian (McLean, Virginia) |
| ABSTRACT | Methods, systems, and apparatus, including computer programs encoded on computer storage media, for monitoring events using a Virtual Inductive Loop system. In some implementations, image data is obtained from cameras. A region depicted in the obtained image data is identified, the region comprising lines spaced by a distance that satisfies a distance threshold. For each line included in the region: an object depicted crossing the line is determined whether to satisfy a height criteria indicating that the line is activated. In response to determining that an object depicted crossing the line satisfies the height criteria, an event is determined to have likely occurred using data indicating (i) which lines of the lines were activated and (ii) an order in which each of the lines were activated. In response to determining that an event likely occurred, actions are performed using at least some of the data. |
| FILED | Tuesday, July 12, 2022 |
| APPL NO | 17/863075 |
| CURRENT CPC | Additional Work, Such as Equipping Roads or the Construction of Platforms, Helicopter Landing Stages, Signs, Snow Fences, or the Like E01F 13/04 (20130101) Image Data Processing or Generation, in General G06T 7/60 (20130101) G06T 7/73 (20170101) G06T 7/80 (20170101) G06T 7/246 (20170101) G06T 2207/30232 (20130101) Image or Video Recognition or Understanding G06V 10/776 (20220101) G06V 20/52 (20220101) Original (OR) Class G06V 2201/08 (20220101) Pictorial Communication, e.g Television H04N 7/181 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230047070 | Lam et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Emory University (Atlanta, Georgia); Georgia Tech Research Corporation (Atlanta, Georgia); Chapman University (Orange, California); Children's Healthcare of Atlanta, Inc. (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wilbur A. Lam (Decatur, Georgia); Caroline Hansen (Atlanta, Georgia); Yumiko Sakurai (Atlanta, Georgia); Andrew Lyon (Irvine, Georgia) |
| ABSTRACT | This disclosure relates to microcapsule particles for targeted delivery of drugs. In certain embodiments, the particles comprise polyelectrolyte polymers, e.g., layers of anionic polymers and cationic polymers. In certain embodiments, the particles have a fibrinogen coating. In certain embodiments, the particles contain a polysaccharide core and/or a polysaccharide coating encapsulating drugs, proteins, clotting agents, coagulation factors, or anticoagulants. In certain embodiments, this disclosure contemplates methods of using particles disclosed herein to prevent or reduce onset of or duration of bleeding. In certain embodiments, this disclosure contemplates methods of using particles disclosed herein to prevent or reduce onset of blood clotting. |
| FILED | Friday, September 23, 2022 |
| APPL NO | 17/934813 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5031 (20130101) Original (OR) Class A61K 9/5036 (20130101) A61K 9/5073 (20130101) A61K 9/5089 (20130101) A61K 38/37 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230047214 | Muratoglu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Orhun K. Muratoglu (Cambridge, Massachusetts); Ebru Oral (Newton, Massachusetts); Scott Grindy (Boston, Massachusetts) |
| ABSTRACT | Provided herein are methods of making degradable, additive-blended polymeric materials using microwave radiation and catalysts. The methods can include incorporation of therapeutic materials into the polymeric materials. There also are provided polymeric materials made by the methods and medical devices comprising the polymeric materials made by the methods. |
| FILED | Wednesday, February 03, 2021 |
| APPL NO | 17/796925 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 2/12 (20130101) A61L 27/34 (20130101) Original (OR) Class A61L 27/52 (20130101) A61L 27/54 (20130101) A61L 27/58 (20130101) A61L 29/16 (20130101) A61L 29/085 (20130101) A61L 29/145 (20130101) A61L 29/148 (20130101) A61L 31/10 (20130101) A61L 31/16 (20130101) A61L 31/145 (20130101) A61L 31/148 (20130101) A61L 2300/402 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 283/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230047323 | WANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chuanlong WANG (Hanover, New Hampshire); Weiyang LI (Hanover, New Hampshire) |
| ABSTRACT | The disclosure relates to metal phosphorothioates, batteries comprising metal phosphorothioate, cells comprising metal phosphorothioate, and methods of making thereof. |
| FILED | Thursday, December 31, 2020 |
| APPL NO | 17/790245 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/625 (20130101) H01M 4/5815 (20130101) Original (OR) Class H01M 10/0525 (20130101) H01M 10/0562 (20130101) H01M 2004/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230047478 | Brito et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Palo Alto Research Center Incorporated (Palo Alto, California) |
| ASSIGNEE(S) | Palo Alto Research Center Incorporated (Palo Alto, California) |
| INVENTOR(S) | Alejandro E. Brito (Mountain View, California); Bashir Sadeghi (East Lansing, Michigan); Shantanu Rane (Palo Alto, California) |
| ABSTRACT | A method and system are provided which facilitate construction of an ensemble of neural network kernel classifiers. The system divides a training set into partitions. The system trains, based on the training set, a first neural network encoder to output a first set of features, and trains, based on each respective partition of the training set, a second neural network encoder to output a second set of features. The system generates, for each respective partition, based on the first and second set of features, kernel models which output a third set of features. The system classifies, by a classification model, the training set based on the third set of features. The generated kernel models for each respective partition and the classification model comprise the ensemble of neural network kernel classifiers. The system predicts a result for a testing data object based on the ensemble of neural network kernel classifiers. |
| FILED | Wednesday, August 11, 2021 |
| APPL NO | 17/400016 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/628 (20130101) G06K 9/6261 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Original (OR) Class G06N 3/0454 (20130101) G06N 20/10 (20190101) G06N 20/20 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230047661 | Radhakrishnan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Faraday Technology, Inc. (Englewood, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rajeswaran Radhakrishnan (Beavercreek, Ohio); Danny Xin Liu (Tipp City, Ohio); Dan Wang (Dublin, Ohio); Timothy D. Hall (Englewood, Ohio); Maria E. Inman (Yellow Springs, Ohio) |
| ABSTRACT | A method of coating a substrate includes adding ion erosion resistant particles, conductive particles, and a binder to an electrophoretic solution in an electrophoretic deposition apparatus including the substrate and a cathode spaced from the substrate. A current is applied to the substrate and cathode to deposit a first layer coating including the erosion resistant particles, the conductive particles, and the binder onto the substrate. The method further includes adding a low work function material to an electrolyte solution in an electrolytic deposition apparatus including the substrate and a cathode spaced from the substrate. A current is applied to the substrate and the cathode to deposit a second layer coating including the low work function material onto the substrate. |
| FILED | Friday, April 08, 2022 |
| APPL NO | 17/716621 |
| CURRENT CPC | Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/44 (20130101) Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 15/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230047730 | Timler et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Science Applications International Corporation (Reston, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John P. Timler (River Ridge, Louisiana); Xingcun C. Tong (Bolingbrook, Illinois) |
| ABSTRACT | A sinterable compound may comprise one or more Ga-alkali metal alloys (and/or one or more Hg-alkali metal amalgams) and one or more filler materials (e.g., one or more dielectric materials). To form a dielectric article or other article, the compound may be formed into a desired shape. Raising the temperature of the compound initiates an exothermic reaction of alkali metal and water and causes the filler materials to self-sinter. |
| FILED | Friday, August 13, 2021 |
| APPL NO | 17/402324 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/64 (20130101) C04B 35/515 (20130101) Original (OR) Class C04B 35/6303 (20130101) C04B 35/63488 (20130101) C04B 2235/5418 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230048006 | Mohan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PALO ALTO RESEARCH CENTER INCORPORATED (Palo Alto, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shiwali Mohan (Palo Alto, California); Matthew Klenk (San Francisco, California); Matthew Shreve (Campbell, California); Aaron Ang (Mountain View, California); John Turner Maxwell, III (Santa Clara, California); Kent Evans (Cupertino, California) |
| ABSTRACT | In one embodiment, a method is provided. The method includes obtaining sensor data indicative of a set of objects detected within an environment. The method also includes determining a set of positions of the set of objects and a set of properties of the set of objects based on the sensor data. The method further includes generating a state graph based on the sensor data. The state graph represents the set of objects and the set of positions of the set of objects. The state graph includes a set of object nodes to represent the set of objects and a set of property nodes to represent the set of properties of the set of objects. The state graph is provided to a graph enhancement module that updates the state graph with additional data to generate an enhanced state graph. |
| FILED | Wednesday, November 03, 2021 |
| APPL NO | 17/518172 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 13/003 (20130101) Original (OR) Class B25J 13/089 (20130101) Electric Digital Data Processing G06F 40/40 (20200101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6252 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230048203 | Xu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Patricia Xu (Ithaca, New York); Robert F. Shepherd (Ithaca, Indiana) |
| ABSTRACT | Provided are three dimensional, stretchable, optical sensor networks that can localize deformations. The devices described herein are suitable for uses in soft robots to determine the position of external contact, such as touching, and possibly internal deformations that may be caused by actuation. Sensor networks of the present disclosure contain a substrate, such as a 3D lattice, and cores having a cladding, such as air. Light passes through the cores and upon deformation of the substrate, cores may come into contact, allowing light to couple between cores due to frustrated total internal reflection. The resulting changes in intensity in the cores can be used to determine the placement and magnitude of deformation. |
| FILED | Monday, September 12, 2022 |
| APPL NO | 17/943184 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 11/16 (20130101) Optical Elements, Systems, or Apparatus G02B 6/125 (20130101) G02B 6/1221 (20130101) Original (OR) Class G02B 2006/12097 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230048286 | Vetrovec |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Jan Vetrovec (Larkspur, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jan Vetrovec (Larkspur, Colorado) |
| ABSTRACT | The present invention provides a blue laser transmitter operating at the H-beta Fraunhofer line at 486.13 nm wavelength. The subject blue laser is based on pulsed lasing action in thulium doped into lutetium sesquioxide (Tm:Lu2O3). The laser wavelength is restricted by volume Bragg grating to the vicinity of 1944 nm wavelength. The laser is operated with a q-switch to generate high-energy pulses within the nanosecond regime. The output at the 1944 nm wavelength is then frequency quadrupled in a single pass through non-linear crystals to a wavelength near the center of the H-beta Fraunhofer line. The operation at the 1944 nm wavelength in Tm:Lu2O3 is very efficient because this wavelength is located on a shoulder of a substantially broad emission peak at 1945 nm. In addition, at the 1944 nm wavelength, Tm:Lu2O3 has only a modest saturation fluence of about 15 J/cm2, which allows for efficient energy extraction. |
| FILED | Thursday, August 11, 2022 |
| APPL NO | 17/886290 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/354 (20210101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/11 (20130101) Original (OR) Class H01S 3/137 (20130101) H01S 3/163 (20130101) H01S 3/1616 (20130101) H01S 3/1685 (20130101) H01S 3/08009 (20130101) H01S 3/094038 (20130101) H01S 2302/00 (20130101) H01S 2303/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230048373 | Mohan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PALO ALTO RESEARCH CENTER INCORPORATED (Palo Alto, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shiwali Mohan (Palo Alto, California); Matthew Klenk (San Francisco, California); Matthew Shreve (Campbell, California); Aaron Ang (Mountain View, California); John Turner Maxwell, III (Santa Clara, California); Kent Evans (Cupertino, California) |
| ABSTRACT | A method is provided. The method includes obtaining a state graph that represents a set of objects within an environment and a set of positions of the set of objects within the environment. The state graph includes a set of object nodes and a set of property nodes. The method also includes obtaining user input data. The user input data is generated based on a natural language input. The method further includes updating the state graph based on the user input data to generate an enhanced state graph. The enhanced state graph includes additional nodes generated based on the user input data. The method further includes providing the enhanced state graph to a planning module. The planning modules generates instructions for operating a mechanical system based on the enhanced state graph. |
| FILED | Wednesday, November 03, 2021 |
| APPL NO | 17/518408 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/163 (20130101) B25J 9/1664 (20130101) Original (OR) Class Electric Digital Data Processing G06F 40/40 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230048589 | Shannon et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America, as represented by the Secretary of the Navy (Patuxent River, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Russell Shannon (Mays Landing, New Jersey); Joseph Garcia (La Plata, Maryland); Aaron Jacobson (King George, Virginia); William Mosca (Morristown, New Jersey); Roberto Maldonado (Lusby, Maryland); Michael Burger (Toms River, New Jersey) |
| ABSTRACT | A method to implement traceability and provability on a particular project in software development based on blockchain-recorded transactions of assigned developer time, the method comprising of the following steps: setting up a blockchain network comprised of a distributed, redundant, and tamper-resistant ledger; issuing each user an attestable pre-fabricated and signed virtualized environment on approved hardware that comes with functionality required for the user's role implemented as one of a set of virtual machine templates fashioned from a signed and approved pre-fabricated image; and verifying that assigned developer time is valid, and if so, record each development action on the ledger to enable extensive tracking and auditing of end- to-end software development process. |
| FILED | Friday, August 13, 2021 |
| APPL NO | 17/401847 |
| CURRENT CPC | Electric Digital Data Processing G06F 8/70 (20130101) G06F 21/53 (20130101) Original (OR) Class G06F 21/54 (20130101) G06F 21/552 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/3236 (20130101) H04L 9/3247 (20130101) H04L 2209/38 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230048660 | Balsiger et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Derick S. Balsiger (Prescott Valley, Arizona); Andrzej Ernest Kuczek (Bristol, Connecticut) |
| ABSTRACT | Disclosed is a gear system, having: first and second ground gear; a drive shaft disposed along a rotation axis of the gear system and configured to rotate about the rotation axis; and an output gear supported by the first and second ground gear and configured to rotate by engagement between a wave generator portion of a drive shaft, a wave generator bearing, a flex spline, the output gear and the first and second ground gear, the output gear defining: an output gear body; and first and second output arms respectively extending radially outward from opposite sides of the output gear body to respectively define first and second radial inner ends and radial outer ends of the first and second output arms, so that the first and second radial outer ends are disposed on a radial axis that extends through a radial center of the gear system. |
| FILED | Wednesday, August 11, 2021 |
| APPL NO | 17/399289 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 13/34 (20130101) Gearing F16H 49/001 (20130101) Original (OR) Class F16H 2049/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230048741 | Farha et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Omar K. Farha (Glenview, Illinois); Zhijie Chen (Evanston, Illinois); Kaikai Ma (Evanston, Illinois); Timur Islamoglu (Evanston, Illinois) |
| ABSTRACT | Textile fibers at least partially coated with a coating that includes particles of metal-organic frameworks dispersed in a polymeric base are provided. Also provided are fabrics formed from the textile fibers, protective gear and articles of clothing made from the fabrics, and methods of using the fibers and fabrics to catalyze the hydrolysis of organic molecules, such as organophosphate-based nerve agents, having hydrolysable bonds. |
| FILED | Wednesday, December 02, 2020 |
| APPL NO | 17/779831 |
| CURRENT CPC | Chemical Means for Extinguishing Fires or for Combating or Protecting Against Harmful Chemical Agents; Chemical Materials for Use in Breathing Apparatus A62D 3/35 (20130101) Original (OR) Class A62D 5/00 (20130101) A62D 2101/02 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/1691 (20130101) Treatment, Not Provided for Elsewhere in Class D06, of Fibres, Threads, Yarns, Fabrics, Feathers or Fibrous Goods Made From Such Materials D06M 13/503 (20130101) D06M 15/61 (20130101) D06M 23/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230048758 | Mohl |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Mohl (Springboro, Ohio) |
| ABSTRACT | A breathing simulator for simulating the dynamic breathing patterns is disclosed. The breathing simulator may include: a gas holding chamber capable of expanding and contracting having a movable portion for expanding and contracting the gas holding chamber; a motion imparting mechanism operatively connected to movable portion of the gas holding chamber; a motion control device for controlling the expansion and contraction of the gas holding chamber; and a motion controller in communication with the motion control device. The motion controller includes software thereon, wherein the software contains an algorithm that express the motion of the movable portion of the gas holding chamber in terms of the equations for a circle in a Cartesian coordinate system, wherein the algorithm provides a mathematically-based breathing profile that is executed by the motion control device. |
| FILED | Friday, July 15, 2022 |
| APPL NO | 17/865450 |
| CURRENT CPC | Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 23/32 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230048788 | D'Addezio et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Joseph D'Addezio (Slidell, Louisiana); Innocent Souopgui (Slidell, Louisiana); Gregg Jacobs (Slidell, Louisiana); Matthew Carrier (Covington, Louisiana); Hans Ngodock (Slidell, Louisiana) |
| ABSTRACT | A method of forecasting an ocean state via a multi-scale two-step assimilation of Surface Water Ocean Topography (SWOT) observations. The method may include receiving data associated with a prior ocean state forecast associated with SWOT observations, determining a large-scale increment state variable based on a large scale correction associated with the prior ocean state forecast, and determining a small scale initial input value based on (i) a combination of the background state associated with the prior ocean state forecast and (ii) the determined large-scale increment state variable. The method may include generating, based on the determined small scale initial input value, a small scale correction associated with the prior ocean state forecast, determining a small-scale increment state variable based on the small scale correction, and generating a current ocean state forecast based on at least some of this information. |
| FILED | Friday, August 05, 2022 |
| APPL NO | 17/881830 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 13/002 (20130101) G01C 13/008 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230048827 | Mohan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PALO ALTO RESEARCH CENTER INCORPORATED (Palo Alto, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shiwali Mohan (Palo Alto, California); Matthew Klenk (San Francisco, California); Matthew Shreve (Campbell, California); Aaron Ang (Mountain View, California); John Turner Maxwell, III (Santa Clara, California); Kent Evans (Cupertino, California) |
| ABSTRACT | A method is provided. The method includes obtaining sensor data indicative of a set of objects detected within an environment. The method also includes generating a state graph based on the sensor data. The state graph includes a set of object nodes and a set of property nodes. The method further includes obtaining user input data generated based on a natural language input. The method further includes updating the state graph based on the user input data to generate an enhanced state graph. The enhanced state graph includes additional nodes generated based on the user input data. The method further includes generating a set of instructions for a set of mechanical systems based on the enhanced state graph. The method further includes operating the set of mechanical systems to achieve a set of objectives based on the set of instructions. |
| FILED | Wednesday, November 03, 2021 |
| APPL NO | 17/518429 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 7/003 (20130101) Original (OR) Class G01B 7/023 (20130101) Electric Digital Data Processing G06F 40/10 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230048960 | Daggett et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Valerie Daggett (Seattle, Washington); Dylan Shea (Seattle, Washington); Alissa Bleem (Seattle, Washington) |
| ABSTRACT | Alpha-sheet polypeptide multimers, and polypeptides for making multimers, compositions and medical devices including them, and their use for treating and diagnosing amyloid diseases or amyloid-associated diseases are disclosed. |
| FILED | Friday, May 20, 2022 |
| APPL NO | 17/749969 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/7007 (20130101) A61K 38/1787 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Peptides C07K 7/06 (20130101) C07K 7/08 (20130101) C07K 14/001 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230049026 | Kotikian et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); Trustees of Boston University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arda Kotikian (Concord, Massachusetts); Jennifer A. Lewis (Cambridge, Massachusetts); Javier M. Morales Ferrer (Allston, Massachusetts); John William Boley (Cambridge, Massachusetts) |
| ABSTRACT | A method of forming an innervated liquid crystal elastomer (iLCE) actuator comprises extruding a filament through a nozzle moving relative to a substrate, where the filament has a core-shell structure including a shell comprising a liquid crystal elastomer surrounding a core configured to induce a nematic-to-isotropic transition of the liquid crystal elastomer. The filament is subjected to UV curing as the filament is extruded, and the filament is deposited on the substrate as the nozzle moves. A director of the liquid crystal elastomer is aligned with a print path of the nozzle, and a 3D printed architecture configured for actuation is formed. |
| FILED | Friday, May 13, 2022 |
| APPL NO | 17/743804 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/118 (20170801) Original (OR) Class Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2105/0079 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230049376 | Crouch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Blackmore Sensors and Analytics, LLC (Palo Alto, California) |
| ASSIGNEE(S) | Blackmore Sensors and Analytics, LLC (Palo Alto, California) |
| INVENTOR(S) | Stephen C. Crouch (Bozeman, Montana); Brant Kaylor (Bozeman, Montana); Randy R. Reibel (Bozeman, Montana) |
| ABSTRACT | A method for classifying an object in a point cloud includes computing first and second classification statistics for one or more points in the point cloud. Closest matches are determined between the first and second classification statistics and a respective one of a set of first and second classification statistics corresponding to a set of N classes of a respective first and second classifier, to estimate the object is in a respective first and second class. If the first class does not correspond to the second class, a closest fit is performed between the point cloud and model point clouds for only the first and second classes of a third classifier. The object is assigned to the first or second class, based on the closest fit within near real time of receiving the 3D point cloud. A device is operated based on the assigned object class. |
| FILED | Tuesday, October 04, 2022 |
| APPL NO | 17/959406 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/4802 (20130101) G01S 7/4808 (20130101) G01S 17/42 (20130101) G01S 17/89 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/628 (20130101) G06K 9/6215 (20130101) Original (OR) Class G06K 9/6276 (20130101) Image or Video Recognition or Understanding G06V 10/40 (20220101) G06V 10/7515 (20220101) G06V 20/64 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230049550 | Roy |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States, as represented by the Secretary of the Army (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Radhika Roy (Howell, New Jersey) |
| ABSTRACT | Various embodiments relate to network capabilities. Devices of a network can have different capabilities. The network can provide artificial intelligence (AI) enabled, machine learning (ML) enabled, deep learning (DL) enabled networked access to these capabilities. The capabilities can share a common AI/ML/DL-enabled open layer-based net-centric logical protocol architecture. Also, different features can be achieved through different layers. As an example, AI enabled access can be achieved through the application layer, ML enabled access and DL enabled access can be achieved through the presentation layer and the session layer, and network access is achieved through the transport layer, the network layer, the link layer, and the physical layer. |
| FILED | Monday, August 16, 2021 |
| APPL NO | 17/402683 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/0051 (20130101) G06K 9/00523 (20130101) G06K 9/6232 (20130101) G06K 9/6256 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230049577 | Gruev |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Israel) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Viktor Gruev (Champaign, Illinois) |
| ABSTRACT | An image sensor capable of recording both spectral and polarization properties of light using a single chip device includes an at least 2048 by 2048 array of superpixels. Each superpixel includes an array of spectral pixels, and an adjacent array of polarization pixels. Each spectral pixel includes a spectral filter and a stack of photodiodes, where each photodiode has a different quantum efficiency and is, therefore, sensitive to a different wavelength of light passed by the spectral filter. Each polarization pixel includes a polarization filter and a stack of photodiodes, similar to the spectral pixel photodiode stacks. |
| FILED | Monday, August 15, 2022 |
| APPL NO | 17/887716 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/2803 (20130101) Original (OR) Class G01J 3/2823 (20130101) G01J 4/04 (20130101) G01J 2003/2806 (20130101) G01J 2003/2826 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230049782 | Park et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | The University of Chicago (Chicago, Illinois) |
| INVENTOR(S) | Jiwoong Park (Chicago, Illinois); Shi En Kim (Chicago, Illinois); Fauzia Mujid (Chicago, Illinois); Joonki Suh (Ulsan, South Korea) |
| ABSTRACT | Articles, devices, and methods including anisotropic van der Waals thermal conductors are described. |
| FILED | Tuesday, August 09, 2022 |
| APPL NO | 17/884115 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/3735 (20130101) Original (OR) Class H01L 23/3736 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230050306 | Anderson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Daniel G. Anderson (Framingham, Massachusetts); Robert Alexander Wesselhoeft (Boston, Massachusetts); Piotr S. Kowalski (Cork, Ireland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel G. Anderson (Framingham, Massachusetts); Robert Alexander Wesselhoeft (Boston, Massachusetts); Piotr S. Kowalski (Cork, Ireland) |
| ABSTRACT | Methods and constructs for engineering circular RNA are disclosed. In some embodiments, the methods and constructs comprise a vector for making circular RNA, the vector comprising the following elements operably connected to each other and arranged in the following sequence: a.) a 5′ homology arm, b.) a 3′ group I intron fragment containing a 3′ splice site dinucleotide, c.) optionally, a 5′ spacer sequence, d.) a protein coding or noncoding region, e.) optionally, a 3′ spacer sequence, f) a 5′ Group I intron fragment containing a 5′ splice site dinucleotide, and g.) a 3′ homology arm, the vector allowing production of a circular RNA that is translatable or biologically active inside eukaryotic cells. Methods for purifying the circular RNA produced by the vector and the use of nucleoside modifications in circular RNA produced by the vector are also disclosed. |
| FILED | Tuesday, August 23, 2022 |
| APPL NO | 17/894141 |
| CURRENT CPC | Peptides C07K 16/2803 (20130101) C07K 2317/31 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) C12N 15/85 (20130101) Original (OR) Class C12N 2015/859 (20130101) C12N 2015/8518 (20130101) C12N 2800/70 (20130101) C12N 2800/107 (20130101) C12N 2800/202 (20130101) C12N 2840/55 (20130101) C12N 2840/60 (20130101) C12N 2840/203 (20130101) C12N 2999/007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230050377 | Willens et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Advanced Materials and Devices (Reno, Nevada) |
| ASSIGNEE(S) | Advanced Materials and Devices (Reno, Nevada) |
| INVENTOR(S) | Kyle Willens (Carson City, Nevada); Blake Muzinich (Reno, Nevada); Barkan Kavlicoglu (Reno, Nevada); Faramarz Gordaninejad (Reno, Nevada) |
| ABSTRACT | A wearable universal blast sensor includes an underwater pressure sensing transducer and at least one blast parameter sensing transducer to measure a blast parameter from the blast other than pressure, an analog-to-digital converter having an analog input and a digital output, the analog input coupled to the pressure sensing transducer and a digital output, a rolling memory buffer coupled to the digital output of the analog-to-digital converter, at least one controller coupled to the rolling memory buffer and configured to store a time sequence of digital pressure signals from the digital output of the analog-to-digital converter, write into a blast event memory data from the rolling memory buffer including data corresponding to the blast event if one of the digital pressure signals exceeds a set first threshold, generate a first blast magnitude indicator signal if any of the digital pressure signals exceeds a second set threshold. |
| FILED | Tuesday, April 19, 2022 |
| APPL NO | 17/724010 |
| CURRENT CPC | Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 5/14 (20130101) Original (OR) Class G01L 19/147 (20130101) G01L 19/149 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230050394 | ULRICH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States, as Represented by The Secretary of The Army (Fort Detrick, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert G. ULRICH (Frederick, Maryland); Teddy KAMATA (Frederick, Maryland) |
| ABSTRACT | The disclosure relates to compositions, assays, methods and kits comprising one or more amino acid sequences of a filovirus protein, or a fragment thereof, which find use in the detection of a filovirus infection and/or the presence of antibodies specific for a filovirus in a biological sample. |
| FILED | Monday, August 08, 2022 |
| APPL NO | 17/883189 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) G01N 2333/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20230050657 — Single Domain Antibodies that Bind and Neutralize Venezuelan Equine Encephalitis Virus
| US 20230050657 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jinny Lin Liu (Ellicott City, Maryland); Dan Zabetakis (Brandywine, Maryland); Ellen R. Goldman (Germantown, Maryland); George P. Anderson (Bowie, Maryland) |
| ABSTRACT | Described herein are single-domain antibodies that might serve as alternatives to conventional monoclonal antibodies for either the detection or treatment of Venezuelan equine encephalitis virus (VEEV). |
| FILED | Wednesday, June 29, 2022 |
| APPL NO | 17/853050 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/552 (20130101) Peptides C07K 16/1081 (20130101) Original (OR) Class C07K 2317/569 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230051001 | Dogariu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aristide Dogariu (Orlando, Florida); Mahdi Eshaghi (Orlando, Florida) |
| ABSTRACT | A polarimeter may include a non-polarizing beamsplitter to split an input beam into a first beam and a second beam, a corner-cube retroreflector to retroreflect the first beam as a polarization-split beam, and a mirror to retroreflect the second beam as a retroreflected second beam. A beam profile of the polarization-split beam includes six regions with different states of polarization associated with a different order of reflections in the corner-cube retroreflector. The non-polarizing beamsplitter may combine the polarization-split beam and the retroreflected second beam as an intensity-split beam having six intensity regions associated with interference of the polarization-split beam with the retroreflected second beam. The polarimeter may further include a detector to measure an intensity of at least some of the six intensity regions and a controller to determine a polarization of the input beam based on the intensities of the at least some of the six intensity regions. |
| FILED | Tuesday, August 16, 2022 |
| APPL NO | 17/888898 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 4/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230051113 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Mo Li (Seattle, Washington); Changming Wu (Seattle, Washington) |
| ABSTRACT | Phase-change metasurface waveguide mode converters and photonic computing systems including a phase-change metasurface waveguide mode converter are described. In an embodiment, the phase-change metasurface waveguide mode converter include a plurality of phase-change antennae comprising a phase-change material and protruding from a surface, wherein each phase-change antenna of the plurality of phase-change antennae is configured to scatter an optical waveguide mode and cause a phase shift of light travelling through an optical waveguide optically coupled thereto. In an embodiment, the phase-change metasurface waveguide mode converter includes the plurality of phase-change antennae configured to alternate between a crystalline phase and an amorphous phase. |
| FILED | Wednesday, April 07, 2021 |
| APPL NO | 17/904787 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/035 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230051136 | Mohan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PALO ALTO RESEARCH CENTER INCORPORATED (Palo Alto, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shiwali Mohan (Palo Alto, California); Matthew Klenk (San Francisco, California); Matthew Shreve (Campbell, California); Aaron Ang (Mountain View, California); John Turner Maxwell, III (Santa Clara, California); Kent Evans (Cupertino, California) |
| ABSTRACT | A method is provided. The method includes obtaining an enhanced state graph. The enhanced state graph represents a set of objects within an environment and a set of positions of the set of objects. The enhanced state graph includes a set of object nodes, a set of property nodes and a set of goal nodes to represent a set of objectives. The method also includes generating a set of instructions for a set of mechanical systems based on the enhanced state graph. The set of mechanical systems is configured to interact with one or more of the set of objects within the environment. The method further includes operating the set of mechanical systems to achieve the set of objectives based on the set of instructions. |
| FILED | Wednesday, November 03, 2021 |
| APPL NO | 17/518417 |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 15/02 (20130101) Original (OR) Class Electric Digital Data Processing G06F 40/40 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230051172 | Suzuki et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PRECISION COMBUSTION, INC. (North Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Toshio Suzuki (Guilford, Connecticut); Timothy LaBreche (Woodbridge, Connecticut); Christian Junaedi (Cheshire, Connecticut); Subir Roychoudhury (Madison, Connecticut); Hongpeng He (Hamden, Connecticut) |
| ABSTRACT | A clad porous metal substrate for use in a metal-supported electrochemical cell, wherein a metal support layer of defined porosity is clad on top and bottom sides with a layer containing a metal and/or a metal oxide. A metal-supported electrochemical half-cell and a metal-supported electrochemical cell are also described. |
| FILED | Wednesday, August 17, 2022 |
| APPL NO | 17/889992 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/8652 (20130101) H01M 4/9025 (20130101) H01M 4/9066 (20130101) H01M 8/0232 (20130101) H01M 8/0236 (20130101) H01M 8/0243 (20130101) H01M 8/0245 (20130101) Original (OR) Class H01M 8/1226 (20130101) H01M 8/1253 (20130101) H01M 2004/8684 (20130101) H01M 2004/8689 (20130101) H01M 2008/1293 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230051247 | Lien et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wen Lien (San Antonio, Texas); Amber M. Mallory (Adkins, Texas); John W. Simecek (Elgin, Texas); Amer Tiba (Lake Bluff, Illinois); Trevor J. Smith (Woodbridge, Virginia); Zakiya R. Skeete (San Antonio, Texas); Andrew P. Zane (Pittsford, New York); Kyumin Whang (Helotes, Texas) |
| ABSTRACT | The present invention relates to nanocapsules, nanocapsule substrate mixtures and processes of making and using same. Such nanocapsule substrate mixtures can provide biological articles such as teeth, bones, and tissues as well as nonbiological articles such as ceramics and polymers, with self-healing capabilities and/or antimicrobial properties. Applicants' nanocapsules allow for a high packing density as well as good mechanical and physical properties that provide the desired performance in each desired application. |
| FILED | Tuesday, August 03, 2021 |
| APPL NO | 17/392432 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 6/17 (20200101) A61K 6/62 (20200101) A61K 6/71 (20200101) A61K 6/893 (20200101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/22 (20130101) Original (OR) Class Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230051351 | Pare et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Oceanit Laboratories, Inc. (Honolulu, Hawaii) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ravi Pare (Kailua, Hawaii); Jimmie Harris (Honolulu, Hawaii); Venkat Kamavaram (Honolulu, Hawaii) |
| ABSTRACT | Disclosed herein are thermally conductive materials, including, for instance, thermally conductive tubing, thermally conductive devices and/or systems (e.g., apparel, backpacks, and the like), and applications thereof. In at least one embodiment, a thermally conductive material is disclosed that is made from one or more base polymers and one or more additives that increase the thermal conductivity of the thermally conductive material relative to the one or more base polymers. In additional embodiments, a cooling vest and a cooling backpack are disclosed, both of which are wearable by human users to keep their body temperature below a certain value. The vest and/or the backpack may include tubing through which coolant flows. The tubing is placed within the fabric and is arranged so that it contacts the user's skin. |
| FILED | Wednesday, August 03, 2022 |
| APPL NO | 17/880575 |
| CURRENT CPC | Outerwear; Protective Garments; Accessories A41D 13/0053 (20130101) Original (OR) Class Travelling or Camp Equipment: Sacks or Packs Carried on the Body A45F 3/04 (20130101) A45F 4/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230051545 | Johnson, JR. et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alan T. Johnson, JR. (Philadelphia, Pennsylvania); Jinglei Ping (Gaithersburg, Maryland) |
| ABSTRACT | Provided are devices and methods for a rapid, non-perturbative and energy-efficient technique for pH sensing based on a flexible graphene electrode. This technique does not require the application of gate voltage or source-drain bias, and demonstrates fast pH-characterization with precision. The disclosed technology is suitable for in vivo monitoring of tumor-induced pH variation in tissues and detection of pH changes as required in a DNA sequencing system. |
| FILED | Friday, April 01, 2022 |
| APPL NO | 17/711134 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/36 (20130101) G01N 27/302 (20130101) G01N 27/308 (20130101) Original (OR) Class G01N 27/4167 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230051585 | Posada |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | US Govt as Rep by the Secretary of the Air Force (Wright Patterson Air Force Base, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Natalia Posada (Dayton, Ohio) |
| ABSTRACT | A portable tracer fluid injection system. The system has a vapor cloud generator which vaporizes a vapor cloud generating liquid. The vapor cloud generator is uses a sub-ohm resistive heater to vaporize small volumes of the vapor cloud generating liquid, allowing for a relatively small tracer fluid injection system. This system has the benefit of being able to target specific regions of a test object within a wind tunnel and being usable for different positions within the test section of a wind tunnel. |
| FILED | Thursday, August 12, 2021 |
| APPL NO | 17/444959 |
| CURRENT CPC | Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 9/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230052264 | Kerber et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Naval Information Warfare Center Pacific (San Diego, California) |
| ASSIGNEE(S) | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (San Diego, California) |
| INVENTOR(S) | Maxwell Matekawa Kerber (San Diego, California); Lewis Hsu (Honolulu, Hawaii); Joseph F. Schnecker, JR. (San Diego, California); Alex G. Phipps (San Diego, California) |
| ABSTRACT | An electrical network including a power source, a flyback converter, a microcontroller, a PID controller, a voltage boost converter, a pulse width modulator integrated circuit, and a battery. The power source produces a charge with a voltage ranging from about 0.1V to about 0.8V and a power ranging from about 0.3 mW to about 100 mW. The flyback converter functions in discontinuous current mode. The microcontroller monitors the power source voltage, calculates a voltage response, and outputs a control signal for the voltage. The PID controller is a digital PID controller, an analog PID controller, or a combination thereof. The voltage boost converter utilizes the power source voltage and power to provide higher voltage power to the electrical network. The pulse width modulator integrated circuit sets a duty cycle and frequency for the flyback converter. The battery stores excess charge produced by the power source. |
| FILED | Thursday, July 29, 2021 |
| APPL NO | 17/388135 |
| CURRENT CPC | Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/46 (20130101) H02J 3/381 (20130101) H02J 2300/30 (20200101) Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/08 (20130101) H02M 3/33515 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230052326 | Nevinsky et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Boeing Company (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael D. Nevinsky (Philadelphia, Pennsylvania); David T. Misciagna (West Chester, Pennsylvania); Joseph Orso (Glen Mills, Pennsylvania); Robert A. DiChiara, JR. (Carlsbad, California); Marc Daniel Spiccia Karasek (Media, Pennsylvania) |
| ABSTRACT | A system and method for mitigating thermal loading between engine exhaust structures having different coefficients of thermal expansion. The engine exhaust structure comprises a metallic duct portion, a ceramic duct portion, and a double bipod fitting joining the metallic duct portion to the ceramic duct portion. The double bipod fitting is capable of flexing and taking up the thermal expansion differences between the joined metallic and ceramic ducts across the full temperature spectrum that an engine exhaust structure will experience in service. |
| FILED | Tuesday, August 10, 2021 |
| APPL NO | 17/444759 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 25/243 (20130101) Original (OR) Class Jet-propulsion Plants F02K 1/80 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/323 (20130101) F05D 2240/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230052446 | FOSTER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Mark FOSTER (Baltimore, Maryland); Milad ALEMOHAMMAD (Baltimore, Maryland); Elliot WAINWRIGHT (Baltimore, Maryland); Timothy P. WEIHS (Baltimore, Maryland); Jasper R. STROUD (Baltimore, Maryland) |
| ABSTRACT | A spectral imaging system includes an objective lens system, an optical splitter, a dispersion system, and an optical combiner. The optical splitter is arranged to be in an optical path of an object being imaged through the objective lens system to provide an imaging optical path and a spectrometer optical path. The dispersion system is arranged in the spectrometer optical path. The optical combiner is arranged in the imaging optical path and a path of dispersed light from the dispersion system to combined dispersed light with a corresponding optical image of the object. |
| FILED | Friday, January 15, 2021 |
| APPL NO | 17/793349 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/31 (20130101) G01N 21/75 (20130101) G01N 2201/0634 (20130101) G01N 2201/0636 (20130101) Optical Elements, Systems, or Apparatus G02B 27/141 (20130101) Image Data Processing or Generation, in General G06T 7/70 (20170101) Original (OR) Class G06T 2207/10016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230052509 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yifan Wang (Singapore, Singapore); Chiara Daraio (South Pasadena, California); Douglas C Hofmann (Altadena, California); Liuchi Li (Berkeley, California); Jose E Andrade (Pasadena, California) |
| ABSTRACT | A structure having a tunable modulus of bending (flexibility) composed of interlocking geometric particles arranged such that an external pressure/force causes them to jam together, increasing the stiffness of the overall structure. Methods for creating the external pressure can include the use of an envelope around the structure that can be evacuated of air. |
| FILED | Thursday, May 19, 2022 |
| APPL NO | 17/748626 |
| CURRENT CPC | Wall, Floor, or Like Covering Materials, e.g Linoleum, Oilcloth, Artificial Leather, Roofing Felt, Consisting of a Fibrous Web Coated With a Layer of Macromolecular Material; Flexible Sheet Material Not Otherwise Provided for D06N 7/00 (20130101) Original (OR) Class D06N 2209/103 (20130101) D06N 2209/128 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230052542 | Russo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Analog Photonics LLC (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter Nicholas Russo (Somerville, Massachusetts); Christopher Vincent Poulton (Cambridge, Massachusetts); Matthew Byrd (Arlington, Massachusetts); Zhan Su (Boston, Massachusetts); Ehsan Hosseini (Boston, Massachusetts); Michael Robert Watts (Hingham, Massachusetts) |
| ABSTRACT | At least one beam of an optical wave is transmitted along a transmission angle toward a target location from a send aperture of a transmitter. The optical wave comprises at least a first portion, and a second portion having a different characteristic from a characteristic of the first portion. Two or more receivers include at least one receiver comprising: a receive aperture arranged in proximity to at least one of the send aperture or a receive aperture of a different receiver, an optical phased array within the receive aperture, the optical phased array being configured to receive at least a portion of a collected optical wave arriving at the receive aperture along a respective collection angle, and a filter configured to filter the received portion of the collected optical wave according to the characteristic of the first portion of the optical wave. |
| FILED | Friday, October 28, 2022 |
| APPL NO | 17/975834 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/4815 (20130101) G01S 7/4816 (20130101) G01S 7/4911 (20130101) G01S 7/4918 (20130101) G01S 17/32 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230052825 | Bishop et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | George Mason Research Foundation, Inc. (Fairfax, Virginia) |
| ASSIGNEE(S) | George Mason Research Foundation, Inc. (Fairfax, Virginia) |
| INVENTOR(S) | Barney Bishop (Annandale, Virginia); Saswata K. Sahoo (Silver Spring, Maryland); Justin Davis (Suffolk, Virginia) |
| ABSTRACT | Peptides and conjugates are described herein, including peptides having antimicrobial and/or anticancer properties, as are compositions, articles, and kits comprising such peptides and conjugates, and methods for using the peptides and conjugates. |
| FILED | Tuesday, August 16, 2022 |
| APPL NO | 17/820013 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 47/65 (20170801) Peptides C07K 14/001 (20130101) C07K 14/4723 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230052931 | Han et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jung Han (New Haven, Connecticut); Rami Elafandy (Hamden, Connecticut) |
| ABSTRACT | III-Nitride layers having spatially controlled regions or domains of porosities therein with tunable optical, electrical, and thermal properties are described herein. Also disclosed are methods for preparing and using such III-nitride layers. |
| FILED | Monday, November 23, 2020 |
| APPL NO | 17/794511 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/26553 (20130101) Original (OR) Class H01L 29/2003 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/18361 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230052995 | Diebold et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric D. Diebold (Los Angeles, California); Bahram Jalali (Los Angeles, California); Brandon Buckley (Los Angeles, California) |
| ABSTRACT | Apparatus and methods for fluorescence imaging using radiofrequency multiplexed excitation. One apparatus splits an excitation laser beam into two arms of a Mach-Zehnder interferometer. The light in the first beam is frequency shifted by an acousto-optic deflector, which is driven by a phase-engineered radiofrequency comb designed to minimize peak-to-average power ratio. This RF comb generates multiple deflected optical beams possessing a range of output angles and frequency shifts. The second beam is shifted in frequency using an acousto-optic frequency shifter. After combining at a second beam splitter, the two beams are focused to a line on the sample using a conventional laser scanning microscope lens system. The acousto-optic deflectors frequency-encode the simultaneous excitation of an entire row of pixels, which enables detection and de-multiplexing of fluorescence images using a single photomultiplier tube and digital phase-coherent signal recovery techniques. |
| FILED | Monday, May 16, 2022 |
| APPL NO | 17/745206 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/05 (20130101) G01N 21/6408 (20130101) Original (OR) Class G01N 21/6458 (20130101) G01N 21/6486 (20130101) G01N 2021/6415 (20130101) G01N 2021/6419 (20130101) G01N 2201/06113 (20130101) Optical Elements, Systems, or Apparatus G02B 21/16 (20130101) G02B 21/0076 (20130101) G02B 21/0084 (20130101) G02B 27/1006 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/11 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230053132 | SAUNDERS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TRITON SYSTEMS, INC. (Chelmsford, Massachusetts) |
| ASSIGNEE(S) | TRITON SYSTEMS, INC. (Chelmsford, Massachusetts) |
| INVENTOR(S) | James F. SAUNDERS (Lowell, Massachusetts); Tyson LAWRENCE (Highlands Ranch, Colorado); Kim HALLETT (Rochester, New Hampshire); Maciej PIETRUSINSKI (Reading, Massachusetts); Olivia CHONG (Somerville, Massachusetts); Marmaduke JD LOKE (Encinitas, California); Max EVANS (Cambridge, Massachusetts) |
| ABSTRACT | A haptic device includes a housing, a first motor configured to rotationally drive a first lead screw, a second motor configured to rotationally drive a second lead screw, and a touch point configured to contact the skin on a distal end. The rotation of the first lead screw is configured to move the touch point along a first axis and the rotation of the second lead screw is configured to move the touch point along a second axis The second axis can be perpendicular to the first axis. The haptic device can be configured to be worn on a user's arm via a wrist band or compression sleeve. |
| FILED | Thursday, August 11, 2022 |
| APPL NO | 17/819228 |
| CURRENT CPC | Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 6/00 (20130101) Original (OR) Class Dynamo-electric Machines H02K 7/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20230046006 | Furman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| INVENTOR(S) | Nicholas J. Furman (Overland Park, Kansas); Kyle Byers (Leawood, Kansas); Daniel Salzman (Lee's Summit, Missouri) |
| ABSTRACT | A base configured to be joined with other bases to form a substrate for an antenna array comprises a body, a plurality of male interconnecting features, and a plurality of female interconnecting features. The body includes a front surface and a rear surface and a plurality of edges positioned therebetween. The front surface or the rear surface is configured to retain an antenna. The male interconnecting features of a first base connect with the female interconnecting features of a second base when the first base is joined with the second base to form the substrate or a portion of the substrate. |
| FILED | Wednesday, August 11, 2021 |
| APPL NO | 17/399363 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 1/12 (20130101) Original (OR) Class H01Q 21/061 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230046316 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jian Liu (Blacksburg, Virginia); Lakshmi Ravi (Blacksburg, Virginia); Dong Dong (Blacksburg, Virginia); Rolando Burgos (Blacksburg, Virginia); Steven Schmalz (Waukesha, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jian Liu (Blacksburg, Virginia); Lakshmi Ravi (Blacksburg, Virginia); Dong Dong (Blacksburg, Virginia); Rolando Burgos (Blacksburg, Virginia); Steven Schmalz (Waukesha, Wisconsin) |
| ABSTRACT | Gate control of power semiconductor devices using reduced gate drivers is disclosed. A circuit breaker may include a multitude of transistors, such as insulated gate bipolar transistors (IGBTs), connected in series with one another. Each transistor may be connected to a respective gate resistor. Diodes may be connected between various gate resistors. One or more resistor-capacitor (RC) snubber circuits may be provided in parallel with one or more of the transistors. Likewise, one or more metal-oxide varistors (MOVs) may be connected in parallel to one or more of the transistors. A gate driver (e.g., a single gate drive) may be connected to the one or more diodes and an emitter of at least one of transistors. |
| FILED | Wednesday, August 10, 2022 |
| APPL NO | 17/885130 |
| CURRENT CPC | Electric Switches; Relays; Selectors; Emergency Protective Devices H01H 9/542 (20130101) Original (OR) Class H01H 33/596 (20130101) H01H 2009/543 (20130101) H01H 2009/544 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230046615 | WILSON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Nolan WILSON (Denver, Colorado); Mark R. Nimlos (Golden, Colorado); John R. DORGAN (East Lansing, Michigan) |
| ABSTRACT | The present disclosure relates to a composition that includes a compound having the structure of a phenolic with three functional groups, R1 R2, and R3, where R1 includes at least one of a hydrogen atom, a hydroxyl group, a first alkoxy group, and/or a first hydrocarbon, R2 includes at least one of a hydrogen atom, a hydroxyl group, a second alkoxy group, and/or a second hydrocarbon, R3 includes at least one of a hydrogen atom, a hydroxyl group, a third alkoxy group, and/or a third hydrocarbon, and the composition has an LC50 of less than about 150 mg compound per mL of the composition for an organism that includes the genus Leptinotarsa. |
| FILED | Monday, December 21, 2020 |
| APPL NO | 17/783316 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 31/08 (20130101) A01N 31/16 (20130101) Original (OR) Class Biocidal, Pest Repellant, Pest Attractant or Plant Growth Regulatory Activity of Chemical Compounds or Preparations A01P 7/04 (20210801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230046888 | Tripathy |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Energy Alliance, LLC (idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Prabhat K. Tripathy (idaho Falls, Idaho) |
| ABSTRACT | A method of recovering a metal from a metal-containing waste material comprises heating a metal-containing waste material under a hydrogen flow to form a hydrided metal material. Hydrogen is removed from the hydrided metal material to form an elemental metal or a metal oxide. Additional methods are disclosed, as are related electrochemical cells. |
| FILED | Thursday, August 11, 2022 |
| APPL NO | 17/819239 |
| CURRENT CPC | Processes for the Electrolytic Production, Recovery or Refining of Metals; Apparatus Therefor C25C 3/28 (20130101) Original (OR) Class C25C 7/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230047140 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Tennessee Research Foundation (Knoxville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Feng Yuan Zhang (Tullahoma, Tennessee); Lei Ding (Tullahoma, Tennessee); Kui Li (Tullahoma, Tennessee); Zhiqiang Xie (Tullahoma, Tennessee); Weitian Wang (Tullahoma, Tennessee); Shule Yu (Tullahoma, Tennessee) |
| ABSTRACT | The presently disclosed subject matter relates to devices, systems, and methods for fabricating a solid polymer electrolyte electrode assembly are provided. One or more electrode for a solid polymer electrolyte electrode assembly includes a porous substrate configured as a liquid/gas diffusion layer and an ionomer-free catalyst coated on the substrate. |
| FILED | Monday, April 11, 2022 |
| APPL NO | 17/717899 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/04 (20130101) C25B 9/19 (20210101) C25B 11/052 (20210101) Original (OR) Class C25B 11/075 (20210101) C25B 11/081 (20210101) C25B 13/08 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 2008/1095 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230047145 | Alexeev et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Yuri Alexeev (Naperville, Illinois); Alexey Galda (Chicago, Illinois); Danylo Lykov (Chicago, Illinois) |
| ABSTRACT | A method for reducing computation time while simulating quantum computation on a classical computer by performing an algorithm used to determine the most efficient input contraction, the method including receiving, by a processor, a tensor network representing a quantum circuit, computing, by the processor, an ordering for the tensor network by an ordering algorithm, contracting, by the processor, the tensor network by eliminating indices according to the ordering resulting in a contracted tensor network, and returning, by the processor, the contracted tensor network. |
| FILED | Wednesday, August 11, 2021 |
| APPL NO | 17/400013 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/20 (20200101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230047374 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Tennessee Research Foundation (Knoxville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Feng Yuan Zhang (Tullahoma, Tennessee); Lei Ding (Tullahoma, Tennessee); Kui Li (Tullahoma, Tennessee); Weitian Wang (Tullahoma, Tennessee); Shule Yu (Tullahoma, Tennessee); Douglas Scott Aaron (Oak Ridge, Tennessee); Matthew M. Mench (Knoxville, Tennessee); Frida Helena Roenning (Knoxville, Tennessee); Anirban Roy (Knoxville, Tennessee) |
| ABSTRACT | The presently disclosed subject matter relates to devices, systems, and methods of producing an improved fluid flow assembly and liquid/gas diffusion layer in solid polymer electrolyte electrochemical cells. In one aspect, a fluid flow assembly for a polymer electrolyte water electrolyzer includes a flow field having an inlet, an outlet, and a plurality of discrete lands arranged within the flow field. A liquid/gas diffusion layer is positioned in communication with the flow field between the inlet and the outlet, the liquid/gas diffusion layer having a solid substrate through which a plurality of pores is formed. The disclosed bipolar plate flow field and liquid/gas diffusion layer could work together or separately with other types of porous transport layers or bipolar plates to enhance the water/gas transport. In these configurations, the lands can be arranged and configured such that the plurality of pores are substantially unobstructed by the lands. |
| FILED | Monday, April 11, 2022 |
| APPL NO | 17/717821 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/026 (20130101) Original (OR) Class H01M 8/0232 (20130101) H01M 8/0234 (20130101) H01M 8/0265 (20130101) H01M 8/1018 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230047410 | Panas |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert M. Panas (Livermore, California) |
| ABSTRACT | An antenna is provided with sub-apertures whose relative locations change and that are not connected via a mechanical link. a Multi-Body Coherent Aperture Synthesis system supports an antenna with sub-aperture devices that collect views, collect (using an optical link) ranging information (that includes timing information) relating to distance between sub-aperture devices, and transmit the collected views and ranging information to a master device. The master device synthesizes the collected views into a synthesized image based on the ranging information. |
| FILED | Monday, August 16, 2021 |
| APPL NO | 17/403130 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 13/08 (20130101) Original (OR) Class G01S 17/08 (20130101) Antennas, i.e Radio Aerials H01Q 1/225 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230047581 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kunlei Liu (Lexington, Kentucky); Heather Nikolic (Stamping Ground, Kentucky) |
| ABSTRACT | A biomass fuel slurry includes a mixture of a biomass material and a plastic material suspended in water. In other embodiments, the biomass fuel slurry also includes coal. A method of making a biomass fuel slurry includes the steps of encapsulating a biomass material with a plastic material to produce a plastic encapsulated biomass material and suspending the plastic encapsulated biomass material in water. |
| FILED | Tuesday, August 02, 2022 |
| APPL NO | 17/879370 |
| CURRENT CPC | Fuels Not Otherwise Provided for; Natural Gas; Synthetic Natural Gas Obtained by Processes Not Covered by Subclasses C10G, C10K; Liquefied Petroleum Gas; Adding Materials to Fuels or Fires to Reduce Smoke or Undesirable Deposits or to Facilitate Soot Removal; Firelighters C10L 1/328 (20130101) Original (OR) Class C10L 2200/0461 (20130101) C10L 2200/0469 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230047624 | Tripathy |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Prabhat K. Tripathy (Idaho Falls, Idaho) |
| ABSTRACT | A method of forming a metal coated article, comprises forming a metal halide in a molten salt plating bath at a first temperature, wherein forming the metal halide in the molten salt further comprises forming at least one functional metal halide electrolyte; and forming at least two auxiliary metal halide electrolytes at eutectic conditions; increasing the first temperature to a second temperature; forming a plated metal coating from the at least one functional metal halide electrolyte, onto a thermally conductive substrate; and introducing at least one of deuterium and tritium into the plated metal coating. |
| FILED | Wednesday, July 20, 2022 |
| APPL NO | 17/813920 |
| CURRENT CPC | Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 3/665 (20130101) Original (OR) Class C25D 5/10 (20130101) C25D 5/50 (20130101) C25D 11/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230047878 | Brouwer |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Lucas Brouwer (Oakland, California) |
| ABSTRACT | An alternative approach to flux pumping in superconducting devices is described for fast and extremely precise tuning of the current during persistent mode operation. Rather than bringing in new flux from outside the circuit, the alternative approach stores a small flux in a tunable inductor (also referred to herein as a “flux bank”) at the initial point of powering. Flux can be transferred back and forth from this bank to the main coil by simply changing the inductance of the bank. This allows for fine and fast adjustments of the persistent current without the use of thermal switches found in other approaches (which limit the adjustment speed and accuracy). |
| FILED | Friday, August 05, 2022 |
| APPL NO | 17/882466 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/3815 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 6/005 (20130101) Original (OR) Class H01F 21/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230048043 | KANAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew W. KANAN (Palo Alto, California); Aanindeeta BANERJEE (Oakland, California); Amy Delano FRANKHOUSER (Oakland, California) |
| ABSTRACT | A method for synthesizing furan-2, 5-dicarboxylate (FDCA2−) is provided. Furan-2-carboxylate is provided with an inorganic base in the form of an inorganic base salt, wherein the furan-2-carboxylate and the inorganic base salt form a mixture. A CO2 gas is provided to the mixture. The mixture is heated to a temperature to at least partially melt the mixture, wherein the heating of the mixture causes the synthesizing of a MxFDCA solid, wherein MxFDCA denotes a salt comprising furan-2,5-dicarboxylate (FDCA2−) and cation M+ and/or M2+, where x is a number between 1 and 2, inclusive. The mixture containing furan-2-carboxylate is mechanically agitated, wherein the mechanically agitating breaks up the MxFDCA solid. |
| FILED | Friday, February 05, 2021 |
| APPL NO | 17/793890 |
| CURRENT CPC | Heterocyclic Compounds C07D 307/68 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230048265 | Cooper et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Baltelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Justin T. Cooper (IDAHO FALLS, Idaho); ARIANA A. FOLEY (LOS ALAMOS, New Mexico); MATHEW S. SNOW (IDAHO FALLS, Idaho); JESSICA L. MEIERS (IDAHO FALLS, Idaho); MATHEW T. KINLAW (Idaho Falls, Idaho) |
| ABSTRACT | A method for producing a radionuclide comprises irradiating a target material with a linear accelerator to produce a radionuclide, dissolving the irradiated target material comprising the radionuclide, and separating the radionuclide from the irradiated target material. Additional methods are disclosed. |
| FILED | Tuesday, August 02, 2022 |
| APPL NO | 17/816965 |
| CURRENT CPC | Conversion of Chemical Elements; Radioactive Sources G21G 1/001 (20130101) G21G 1/10 (20130101) Original (OR) Class G21G 2001/0094 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230048467 | Celik et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Gokhan Celik (Clarendon Hills, Illinois); Kimaya Prakash Vyavhare (Woodridge, Illinois); Robert M. Kennedy (Evanston, Illinois); Ryan Hackler (Chicago, Illinois); Ali Erdemir (Naperville, Illinois); Massimiliano Delferro (Chicago, Illinois) |
| ABSTRACT | A method of upcycling polymers to useful hydrocarbon materials. A catalyst with nanoparticles on a substrate selectively docks and cleaves longer hydrocarbon chains over shorter hydrocarbon chains. The nanoparticles exhibit an edge to facet ratio to provide for more interactions with the facets. |
| FILED | Tuesday, October 25, 2022 |
| APPL NO | 17/973381 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/04 (20130101) B01J 23/002 (20130101) B01J 23/02 (20130101) B01J 23/42 (20130101) B01J 23/755 (20130101) B01J 35/0013 (20130101) Lubricating Compositions; Use of Chemical Substances Either Alone or as Lubricating Ingredients in a Lubricating Composition C10M 105/04 (20130101) C10M 107/02 (20130101) C10M 111/04 (20130101) Original (OR) Class C10M 177/00 (20130101) C10M 2203/022 (20130101) C10M 2205/0206 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230048543 | KAMPASI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Komal KAMPASI (San Francisco, California); Eric B. DUOSS (Danville, California); Razi-Ul Muhammad HAQUE (San Francisco, California) |
| ABSTRACT | The present disclosure relates to a spatio-temporal stimulus responsive foldable structure. The structure may have a substrate having at least a region formed to provide engineered weakness to help facilitate bending or folding of the substrate about the region of engineered weakness. The substrate is formed to have a first shape. A stimulus responsive polymer (SRP) flexure is disposed at the region of engineered weakness. The SRP flexure is responsive to a predetermined stimulus actuation signal to bend or fold in response to exposure to the stimulus actuation signal, to cause the substrate to assume a second shape different from the first shape. |
| FILED | Monday, August 16, 2021 |
| APPL NO | 17/402676 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 3/30 (20130101) Original (OR) Class B32B 7/023 (20190101) B32B 7/025 (20190101) B32B 7/027 (20190101) B32B 27/08 (20130101) B32B 27/281 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230049075 | Cahill et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-BATTELLE, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John F. Cahill (Knoxville, Tennessee); Vilmos Kertesz (Oak Ridge, Tennessee); Scott T. Retterer (Knoxville, Tennessee) |
| ABSTRACT | A system for sampling a liquid includes a sample fluid conduit including a membrane having pores. The membrane prevents the passage of the sample liquid through the pores at a first pressure of the sample liquid in the sample fluid conduit. A surface sampling capture probe has a distal end. The capture probe includes a solvent supply conduit and a solvent exhaust conduit. A solvent composition flowing at the distal end of the capture probe establishes a liquid junction with the membrane and establishes a second pressure within the liquid junction at the membrane. The second pressure is lower than the first pressure. Sample liquid will be drawn through the pores of the membrane by the second pressure at the liquid junction. A method for sampling a liquid and for performing chemical analysis on a liquid are also disclosed. |
| FILED | Monday, August 15, 2022 |
| APPL NO | 17/888397 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/10 (20130101) G01N 30/7233 (20130101) G01N 35/1095 (20130101) G01N 2001/028 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/0454 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230049093 | Ramasamy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington); LanzaTech, Inc. (Skokie, Illinois) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington); LanzaTech, Inc. (Skokie, Illinois) |
| INVENTOR(S) | Karthikeyan K. Ramasamy (West Richland, Washington); Mond Guo (Richland, Washington); Richard Russell Rosin (Glencoe, Illinois); Joseph Anthony Kocal (Glenview, Illinois) |
| ABSTRACT | Disclosed herein are embodiments of a method and system for converting ethanol to para-xylene. The method also provides a pathway to produce terephthalic acid from biomass-based feedstocks. In some embodiments, the disclosed method produces p-xylene with high selectivity over other aromatics typically produced in the conversion of ethanol to xylenes, such as m-xylene, ethyl benzene, benzene, toluene, and the like. And, in some embodiments, the method facilitates the ability to use ortho/para mixtures of methylbenzyaldehyde for preparing ortho/para xylene product mixtures that are amendable to fractionation to separate the para- and ortho-xylene products thereby providing a pure feedstock of para-xylene that can be used to form terephthalic anhydride and a pure feedstock of ortho-xylene that can be used for other purposes, such as phthalic anhydride. |
| FILED | Tuesday, April 05, 2022 |
| APPL NO | 17/713686 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 1/2076 (20130101) Original (OR) Class C07C 7/04 (20130101) C07C 45/68 (20130101) C07C 2521/04 (20130101) C07C 2521/06 (20130101) C07C 2521/18 (20130101) C07C 2523/44 (20130101) C07C 2523/656 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230049215 | Lu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | Yi Lu (Austin, Texas); Mingkuan Lyu (Champaign, Illinois) |
| ABSTRACT | Systems and kits are disclosed herein for genetic engineering (such as for DNA cleavage and gene-editing), which include catalytic nucleic acids and catalytic nucleic acid-assisting reagents. Methods of genetic engineering are also described, in which both catalytic nucleic acid-assisting reagents and catalytic nucleic acids are specific for a target site, thus, providing high-fidelity genetic engineering. |
| FILED | Friday, December 18, 2020 |
| APPL NO | 17/786865 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/102 (20130101) Original (OR) Class C12N 15/113 (20130101) C12N 2310/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230050093 | Wilson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Air Squared, Inc. (Broomfield, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John P.D. Wilson (Denver, Colorado); Nathan D. Nicholas (Westminster, Colorado) |
| ABSTRACT | A dual-drive co-rotating scroll device includes a housing; a first scroll rotatably mounted within the housing via a first cylindrical extension and a first plurality of bearings, and having a first axis of rotation; and a second scroll rotatably mounted within the housing via a second cylindrical extension and a second plurality of bearings, and having a second axis of rotation different than the first axis of rotation. At least one of the first cylindrical extension and the second cylindrical extension may comprise a plurality of permanent magnets and operate as a rotor of a first motor. An Oldham ring may be positioned between the first scroll and the second scroll and configured to maintain a relative angular position between the first scroll and the second scroll. |
| FILED | Monday, October 24, 2022 |
| APPL NO | 17/972165 |
| CURRENT CPC | Rotary-piston, or Oscillating-piston, Positive-displacement Machines for Liquids; Rotary-piston, or Oscillating-piston, Positive-displacement Pumps F04C 18/023 (20130101) Original (OR) Class F04C 29/02 (20130101) F04C 29/0085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230050231 | Kern et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Brandeis University (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dorothee Kern (Waltham, Massachusetts); Adelajda Zorba (Waltham, Massachusetts) |
| ABSTRACT | The present invention features an antibody mimetic, or an antigen binding fragment thereof, that specifically binds to an allosteric site of Aurora A kinase, therapeutic compositions comprising this antibody mimetic, and the use of the monobody to modulate Aurora A kinase for the treatment of cancer. |
| FILED | Tuesday, July 20, 2021 |
| APPL NO | 17/380704 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5008 (20130101) Original (OR) Class G01N 2333/47 (20130101) G01N 2333/91205 (20130101) G01N 2500/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230050490 | Razeghi-Jahromi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ABB Schweiz AG (Baden, Switzerland) |
| ASSIGNEE(S) | ABB Schweiz AG (Baden, Switzerland) |
| INVENTOR(S) | Mohammad Razeghi-Jahromi (Cary, North Carolina); David Lee Coats (Apex, North Carolina); James D. Stoupis (Raleigh, North Carolina) |
| ABSTRACT | A method for determining whether a power system is encountering a malicious attack is provided. The method comprises: receiving a plurality of first phasor measurement unit (PMU) measurements from a plurality of PMUs of the power system; determining a plurality of expected PMU measurements associated with a future time period based on an optimization algorithm that uses differences between a plurality of consecutive predictive entries and the plurality of first PMU measurements; receiving, from the plurality of PMUs, a plurality of second PMU measurements associated with the future time period; determining whether the power system is encountering the malicious attack based on comparing the plurality of expected PMU measurements with the plurality of second PMU measurements; and executing an action based on whether the power system is encountering the malicious attack. |
| FILED | Wednesday, August 04, 2021 |
| APPL NO | 17/393767 |
| CURRENT CPC | Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 13/00002 (20200101) H02J 13/00016 (20200101) H02J 13/00032 (20200101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/1416 (20130101) Original (OR) Class H04L 63/1466 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230050691 | Gu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qinchen Gu (Atlanta, Georgia); Abdul Raheem Beyah (Atlanta, Georgia) |
| ABSTRACT | A system (100) and method for detecting a malicious programmable logic controller (PLC) code segment (110) in a PLC program corresponding to a specific type of PLC includes a binary parser (112) that parses the code segment (110) into a plurality of functional elements. A variable and function block mapper (114) maps the functional elements into a high-level data structure. A fuzzer (116) generates a behavioral model of the high-level data structure into an automaton (118). A classifier (120) predicts to which processes the automaton (118) corresponds. A detector (122) detects unsafe states in the automaton (118) and that generates an indication of a detected unsafe state. |
| FILED | Saturday, January 16, 2021 |
| APPL NO | 17/789439 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/554 (20130101) Original (OR) Class G06F 2221/034 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230050837 | BRUPBACHER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| INVENTOR(S) | Michael BRUPBACHER (Catonsville, Maryland); Dajie ZHANG (Baltimore, Maryland); Dennis NAGLE (Arnold, Maryland) |
| ABSTRACT | The present invention is directed to methods for formation of refractory carbide, nitride, and boride coatings without use of a binding agent. The present invention is directed to methods of creating refractory coatings with controlled porosity. Refractory coatings can be formed from refractory metal, metal oxide, or metal/metal oxide composite refractory coating precursor of the 9 refractory metals encompassed by groups 4-6 and periods 4-6 of the periodic table; non-metallic elements (e.g. Si & B) and their oxides (i.e. SiO2 & B2O3) are also pertinent. The conversion of the refractory coating precursor to refractory carbide, nitride or boride is achieved via carburization, nitridization, or boridization in the presence of carbon-containing (e.g. CH4), nitrogen containing (e.g. NH3), and boron-containing (e.g. B2H6) gaseous species. Any known technique of applying the refractory coating precursor can be used. The porosity of resultant refractory coatings is controlled through compositional manipulation of composite refractory coating precursors. |
| FILED | Tuesday, August 23, 2022 |
| APPL NO | 17/821483 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 4/08 (20130101) C23C 4/11 (20160101) C23C 4/18 (20130101) C23C 4/134 (20160101) Original (OR) Class C23C 8/02 (20130101) C23C 8/08 (20130101) C23C 8/20 (20130101) C23C 8/24 (20130101) C23C 18/08 (20130101) C23C 24/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230051157 | Kallupalayam Ramasamy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BATTELLE MEMORIAL INSTITUTE (Richland, Washington) |
| ASSIGNEE(S) | BATTELLE MEMORIAL INSTITUTE (Richland, Washington) |
| INVENTOR(S) | Karthikeyan Kallupalayam Ramasamy (West Richland, Washington); Mond F. Guo (Richland, Washington); Senthil Subramaniam (Richland, Washington); Udishnu Sanyal (Richland, Washington); Casper O. Brady (Pasco, Washington) |
| ABSTRACT | A method for forming a desired hydrocarbon fuel product from a mixed oxygenate feedstock by utilizing chemical processes to form ketones from the oxygenate feed, upgrade the ketones, recycle selected upgraded ketones through the upgrading process to obtain a desired intermediate and hydrogenating the desired intermediate to obtain the desired hydrocarbon fuel product. In various alternative configurations and embodiments this can be accomplished in a number of ways, and originate in a number of different positions and occasions. |
| FILED | Friday, September 23, 2022 |
| APPL NO | 17/951385 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/129 (20170801) B29C 64/135 (20170801) B29C 64/268 (20170801) Original (OR) Class B29C 64/291 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230051729 | LIU |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Molecule Works Inc. (Richland, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wei LIU (Richland, Washington) |
| ABSTRACT | A method for producing metal-based micro-porous structures includes continuously feeding a solid green part and a gas flow into a tunnel reactor having an aspect ratio greater than 2, wherein the solid green part has a characteristic diffusion mass transfer dimension less than 1 mm and a gas in the gas flow is substantially free of oxidants, and chemically reacting the gas in the gas flow and the green part under a predetermined temperature profile along a length of the tunnel reactor for a sufficient time to convert the green part into a solid product having pore sizes in a range of 0.3 nm to 5 μm. |
| FILED | Tuesday, September 13, 2022 |
| APPL NO | 17/943680 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 3/1039 (20130101) B22F 3/1143 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 8/02 (20130101) C23C 8/06 (20130101) Original (OR) Class C23C 8/60 (20130101) C23C 16/28 (20130101) C23C 16/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230051932 | Hollas et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BATTELLE MEMORIAL INSTITUTE (Richland, Washington) |
| ASSIGNEE(S) | BATTELLE MEMORIAL INSTITUTE (Richland, Washington) |
| INVENTOR(S) | Aaron M. Hollas (Richland, Washington); Guosheng Li (Richland, Washington); Minyuan Mil Li (Richland, Washington); Qian Huang (Richland, Washington); David M. Reed (Richland, Washington); Vincent L. Sprenkle (Richland, Washington) |
| ABSTRACT | An anolyte for a redox-flow battery (RFB) comprising a metal-ion complex and a phosphonate-based ligand having a phosphonic group wherein the phosphonic acid group is directly coordinated to a metal-ion. |
| FILED | Tuesday, August 16, 2022 |
| APPL NO | 17/889067 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 15/025 (20130101) Original (OR) Class Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/188 (20130101) H01M 2300/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230052578 | Heher et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Transportation IP Holdings, LLC (Norwalk, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brett Heher (Pittsburgh, Pennsylvania); Adam Edgar Klingbeil (Ballston Lake, New York); Manuel Licon Flores (Erie, Pennsylvania); Kevin Paul Bailey (Mercer, Pennsylvania) |
| ABSTRACT | An insert device includes a body having an upper body portion configured to couple with a cylinder head of an engine cylinder and a lower body portion extending from the upper body portion toward a combustion chamber of the engine cylinder. The body includes an interior surface extending around a central volume positioned to receive liquid fuel from a fuel injector. The body includes gas inlet channels and fuel-and-gas mixture outlet channels. The gas inlet channels direct gas into the central volume where the gas mixes with the liquid fuel to form the fuel-and-gas mixture. The fuel-and-gas mixture outlet channels direct the mixture into the combustion chamber. The interior surface includes concave surface portions between the inlet channels and the outlet channels along a center axis of the body that are shaped to direct the gas into the central volume toward the liquid fuel in the central volume. |
| FILED | Thursday, August 12, 2021 |
| APPL NO | 17/401284 |
| CURRENT CPC | Mixing, e.g Dissolving, Emulsifying, Dispersing B01F 3/0446 (20130101) B01F 5/0475 (20130101) B01F 2215/0086 (20130101) Internal-combustion Piston Engines; Combustion Engines in General F02B 23/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230052973 | Ridley et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Other Lab, LLC (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brent Ridley (Huntington Beach, California); Jean Chang (San Francisco, California); Leah Bryson (Oakland, California) |
| ABSTRACT | A thermally adaptive material configured to assume a lofted configuration and flat configuration in response to different temperatures. The thermally adaptive material includes an adaptive first textile layer with one or more sections of a first material that has a first thermal expansion coefficient and one or more sections of a second material disposed adjacent to the one or more sections of the first material, the one or more sections of the second material having a second thermal expansion coefficient that is different from the first thermal expansion coefficient. The thermally adaptive material also includes a second textile layer disposed opposing the adaptive first textile layer; a plurality of engaging portions between the first textile layer and second textile layer; and one or more cavities defined by the first and second layers that are generated while the adaptive textile is at least in a lofted configuration. |
| FILED | Friday, October 28, 2022 |
| APPL NO | 17/976634 |
| CURRENT CPC | Outerwear; Protective Garments; Accessories A41D 31/065 (20190201) Original (OR) Class Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 7/027 (20190101) B32B 27/12 (20130101) B32B 2307/30 (20130101) B32B 2437/00 (20130101) Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles D10B 2401/04 (20130101) D10B 2501/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230053015 | Vetrovec |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Jan Vetrovec (Larkspur, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jan Vetrovec (Larkspur, Colorado) |
| ABSTRACT | This invention is for an innovative magnetic air separator (MAS) for delivering oxygen-enriched air or near-pure oxygen to for advanced combustion, coal gasification, industrial processes, and medical applications. In the MAS of the subject invention, input air is drawn into a large array of microchannels immersed in a strong, spatially varying magnetic field. Magnetic forces accelerate the paramagnetic O2 molecules within the microchannel flow and in a direction perpendicular to it, thus forming enriched and depleted streams. Such streams are then physically separated and subsequently combined according to their level of O2 enrichment or depletion. Highly enriched streams are repeatedly subjected to the magnetic separation process until the targeted level of O2 concentration is reached in selected streams. Partially enriched streams are recycled and fed back into the process feedstock air, while depleted streams are vented from the process. |
| FILED | Monday, August 16, 2021 |
| APPL NO | 17/300556 |
| CURRENT CPC | Magnetic or Electrostatic Separation of Solid Materials From Solid Materials or Fluids; Separation by High-voltage Electric Fields B03C 1/035 (20130101) B03C 1/0332 (20130101) Original (OR) Class B03C 2201/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230053268 | Garcia, JR. et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sortera Alloys, Inc. (Fort Wayne, Indiana) |
| ASSIGNEE(S) | Sortera Alloys, Inc. (Fort Wayne, Indiana) |
| INVENTOR(S) | Manuel Gerardo Garcia, JR. (Fort Wayne, Indiana); Nalin Kumar (Fort Worth, Texas); Casey Lee Hughlett (Fort Wayne, Indiana) |
| ABSTRACT | A material handling system sorts materials utilizing a vision system of multiple vision devices configured with single board computers that each implement an artificial intelligence system in order to identify or classify materials, which are then sorted into separate groups based on such an identification or classification by sorting devices that are each coupled to one of the vision devices. |
| FILED | Monday, October 24, 2022 |
| APPL NO | 17/972541 |
| CURRENT CPC | Separating Solids From Solids by Sieving, Screening, Sifting or by Using Gas Currents; Separating by Other Dry Methods Applicable to Bulk Material, e.g Loose Articles Fit to be Handled Like Bulk Material B07B 13/003 (20130101) Original (OR) Class B07B 13/18 (20130101) Postal Sorting; Sorting Individual Articles, or Bulk Material Fit to be Sorted Piece-meal, e.g by Picking B07C 5/342 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/627 (20130101) Image Data Processing or Generation, in General G06T 7/0006 (20130101) G06T 2207/30136 (20130101) G06T 2207/30141 (20130101) Image or Video Recognition or Understanding G06V 10/46 (20220101) G06V 2201/06 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20230045854 | Cao |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gang Cao (Broomfield, Colorado) |
| ABSTRACT | Various embodiments include a device for producing structurally modified materials. In some embodiments, the device includes a floating zone furnace which holds a feed rod in contact with seed crystal. One or more laser diodes are then used to heat a portion of the feed rod and cause it to transition to a molten state. A magnetic field is applied to the floating zone to change the underlying crystal structure of the material as it solidifies upon exiting the floating zone. In some instances, the changes may include manipulating the bond angle of the crystal structure or altering the unit cell volume of the crystal. Changes in the crystal structure directly affect the electrical resistivity and/or the magnetization and other physical properties of the crystal. |
| FILED | Thursday, January 21, 2021 |
| APPL NO | 17/794108 |
| CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 13/24 (20130101) C30B 13/30 (20130101) Original (OR) Class C30B 29/22 (20130101) C30B 30/04 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 6/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230045859 | Halperin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); Doheny Eye Institute (Los Angeles, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California); Doheny Eye Institute (Los Angeles, California) |
| INVENTOR(S) | Eran Halperin (Santa Monica, California); Nadav Rakocz (Los Angeles, California); Jeffrey Chiang (Los Angeles, California); Muneeswar Gupta (Los Angeles, California); Srinivas Sadda (Los Angeles, California) |
| ABSTRACT | Deep learning methods and systems for detecting biomarkers within optical coherence tomography volumes using such deep learning methods and systems are provided. Embodiments predict the presence or absence of clinically useful biomarkers in OCT images using deep neural networks. The lack of available training data for canonical deep learning approaches is overcome in embodiments by leveraging a large external dataset consisting of foveal scans using transfer learning. Embodiments represent the three-dimensional OCT volume by “tiling” each slice into a single two dimensional image, and adding an additional component to encourage the network to consider local spatial structure. Methods and systems, according to embodiments are able to identify the presence or absence of AMD-related biomarkers on par with clinicians. Beyond identifying biomarkers, additional models could be trained, according to embodiments, to predict the progression of these biomarkers over time. |
| FILED | Monday, January 25, 2021 |
| APPL NO | 17/758625 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/102 (20130101) A61B 3/1225 (20130101) A61B 5/7275 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/10101 (20130101) G06T 2207/20081 (20130101) G06T 2207/30041 (20130101) Image or Video Recognition or Understanding G06V 10/44 (20220101) G06V 10/774 (20220101) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230045959 | Smith et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Joshua R. Smith (Seattle, Washington); Jared Nakahara (Seattle, Washington); Boling Yang (Seattle, Washington) |
| ABSTRACT | System and method for non-contact manipulation of objects via ultrasonic levitation are presented herein. In one embodiment, a method for a non-contact manipulation of an object includes: generating ultrasound field by an array of ultrasound transducers; lifting the object off a dispensing device by the ultrasound field; and levitating the object by the ultrasound field. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/798267 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 15/0019 (20130101) Sound-producing Devices; Methods or Devices for Protecting Against, or for Damping, Noise or Other Acoustic Waves in General; Acoustics Not Otherwise Provided for G10K 11/346 (20130101) G10K 11/352 (20130101) G10K 15/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230046551 | Chakrabartty |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shantanu Chakrabartty (St. Louis, Missouri) |
| ABSTRACT | A sensor blockchain system is provided. The sensor blockchain system includes a plurality of sensor-data-loggers, wherein each sensor-data-logger includes a memory device which utilizes FN tunneling. An input to the sensing interface alters the geometry of the energy barrier to change the electron leakage rate and the current state of the sensor-data logger is determined by an initial state of the sensor-data-logger, the predetermined electron leakage rate, and any inputs to the sensing interface. The sensor-data-loggers may be synchronized to an initial state. The synchronization will be maintained when they are all subjected to similar changes in environmental conditions in a supply chain. Desynchronization will occur due to changes in environment, including changes in temperature. |
| FILED | Friday, August 12, 2022 |
| APPL NO | 17/819484 |
| CURRENT CPC | Electric Digital Data Processing G06F 17/40 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 9/50 (20220501) Wireless Communication Networks H04W 4/38 (20180201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230046768 | NARASIMHAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania); WILLIAM MARSH RICE UNIVERSITY (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Srinivasa NARASIMHAN (Pittsburgh, Pennsylvania); Chao LIU (Pittsburgh, Pennsylvania); Ashutosh SABHARWAL (Houston, Texas); Akash K. MAITY (Houston, Texas); Artur DUBRAWSKI (Pittsburgh, Pennsylvania) |
| ABSTRACT | A fast imaging apparatus and method for high resolution diffuse optical tomography with a line imaging and illumination system is disclosed. The method uses an algorithm comprising a convolution approximation of the forward heterogeneous scattering model that can be inverted to produce deeper than ever before structured beneath the surface. The method can detect reasonably accurate boundaries and relative depth of absorption variations up to a depth of approximately 8 mm below highly scattering medium such as skin. |
| FILED | Wednesday, April 21, 2021 |
| APPL NO | 17/631905 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0073 (20130101) Original (OR) Class A61B 5/0077 (20130101) A61B 2562/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230047669 | Josephs et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric Josephs (Durham, North Carolina); Dewran Kocak (Durham, North Carolina); Piotr Marszalek (Durham, North Carolina); Charles A. Gersbach (Chapel Hill, North Carolina) |
| ABSTRACT | Disclosed herein are optimized guide RNAs (gRNAs) that have increased target binding specificity and reduced off-target binding. Further disclosed herein are methods of designing and using the optimized gRNAs. |
| FILED | Tuesday, August 02, 2022 |
| APPL NO | 17/879506 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) Original (OR) Class C12N 15/111 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/10 (20190201) G16B 15/30 (20190201) G16B 25/00 (20190201) G16B 30/10 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230048370 | Lew et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Matthew Lew (St. Louis, Missouri); Tingting Wu (St. Louis, Missouri) |
| ABSTRACT | Systems, devices, and methods for producing an optimized phase mask for use in a single-molecule orientation localization microscopy (SMOLM) imaging system are disclosed. |
| FILED | Thursday, August 04, 2022 |
| APPL NO | 17/880648 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 21/6445 (20130101) G01N 21/6458 (20130101) Original (OR) Class G01N 2021/6439 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230049026 | Kotikian et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); Trustees of Boston University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arda Kotikian (Concord, Massachusetts); Jennifer A. Lewis (Cambridge, Massachusetts); Javier M. Morales Ferrer (Allston, Massachusetts); John William Boley (Cambridge, Massachusetts) |
| ABSTRACT | A method of forming an innervated liquid crystal elastomer (iLCE) actuator comprises extruding a filament through a nozzle moving relative to a substrate, where the filament has a core-shell structure including a shell comprising a liquid crystal elastomer surrounding a core configured to induce a nematic-to-isotropic transition of the liquid crystal elastomer. The filament is subjected to UV curing as the filament is extruded, and the filament is deposited on the substrate as the nozzle moves. A director of the liquid crystal elastomer is aligned with a print path of the nozzle, and a 3D printed architecture configured for actuation is formed. |
| FILED | Friday, May 13, 2022 |
| APPL NO | 17/743804 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/118 (20170801) Original (OR) Class Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2105/0079 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230049782 | Park et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | The University of Chicago (Chicago, Illinois) |
| INVENTOR(S) | Jiwoong Park (Chicago, Illinois); Shi En Kim (Chicago, Illinois); Fauzia Mujid (Chicago, Illinois); Joonki Suh (Ulsan, South Korea) |
| ABSTRACT | Articles, devices, and methods including anisotropic van der Waals thermal conductors are described. |
| FILED | Tuesday, August 09, 2022 |
| APPL NO | 17/884115 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/3735 (20130101) Original (OR) Class H01L 23/3736 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230049990 | Matyjaszewski et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Krzysztof Matyjaszewski (Pittsburgh, Pennsylvania); Jianan Zhang (Hefei, China PRC); Michael R. Bockstaller (Pittsburgh, Pennsylvania) |
| ABSTRACT | A method for preparation of mesoporous nitrogen-doped carbon includes forming a composition by solubilizing a nitrogen-containing polymer in an aqueous solution of ZnCl2 and drying the aqueous solution, the method further includes heating the composition after drying to a temperature sufficiently high to carbonize the nitrogen-containing polymer to form the mesoporous nitrogen-doped carbon. |
| FILED | Tuesday, October 04, 2022 |
| APPL NO | 17/959913 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/21 (20170801) C01B 32/354 (20170801) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2006/12 (20130101) C01P 2006/14 (20130101) C01P 2006/17 (20130101) Compositions of Macromolecular Compounds C08L 33/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230050038 | Imoukhuede et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri); The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri); The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | Princess Imoukhuede (St. Louis, Missouri); Erik Procko (Urbana, Illinois) |
| ABSTRACT | Isolated polypeptides having enhanced affinity for a PDGF receptor and/or a VEGF receptor are provided. Compositions comprising the polypeptides and methods of use thereof are also provided. |
| FILED | Thursday, June 09, 2022 |
| APPL NO | 17/836684 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1858 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) A61P 35/00 (20180101) Peptides C07K 16/22 (20130101) Original (OR) Class C07K 2317/76 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230050241 | Yang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Rhode Island Board of Trustees (Kingston, Rhode Island) |
| ASSIGNEE(S) | University of Rhode Island Board of Trustees (Kingston, Rhode Island) |
| INVENTOR(S) | Ken Qing Yang (Saunderstown, Rhode Island); Tao Wei (West Kingston, Rhode Island); Zhenyu Xu (Kingston, Rhode Island) |
| ABSTRACT | Method and apparatus for detecting in impedance change in a transmission line, such as a line in a computer bus. A CMOS-compatible time domain reflectometer circuit comprising a comparator is embedded in one or more chips and connected to the transmission line. The circuit measures the impedance inhomogeneity pattern (IIP) of the transmission line prior to use, and then repeatedly measures the HP during operation of the transmission line to detect a change in IIP, without Interfering with data transfer through the transmission line. The present invention can detect and locate wire-tapping magnetic probing or snooping, and Trojan and cold boot attacks on interconnecting buses between computer chips or integrated circuits in a computer system, such as on external memory buses. |
| FILED | Friday, January 29, 2021 |
| APPL NO | 17/795997 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/11 (20130101) Original (OR) Class G01R 31/085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230051277 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peiran Zhang (Durham, North Carolina); Joseph Rufo (Durham, North Carolina); Tony Jun Huang (Durham, North Carolina) |
| ABSTRACT | Technologies for acoustoelectronic manipulation of micro/nano particles include a system having a piezoelectric substrate coupled to one or more acoustic transducers and a fluid layer positioned above the substrate. Micro/nano particles are introduced to the fluid, which can be in the form of a droplet or in a confined channel, and a signal is applied to the acoustic transducer. One or more parameters of the signal are varied after introducing the micro/nano particles into the fluid. The parameters may include amplitude, frequency, or phase of the signal. The system may include one or more acoustic transducers. Multiple signals may be applied to the acoustic transducers. Wave superposition of acoustic waves in the substrate manipulates micro/nano particles in the fluid. The nanoparticles may include carbon nanotubes, nanowires, nanofibers, graphene flakes, quantum dots, SERS probes, exosomes, vesicles, DNA, RNA, antibodies, antigens, macromolecules, or proteins. |
| FILED | Tuesday, August 09, 2022 |
| APPL NO | 17/883883 |
| CURRENT CPC | Methods or Apparatus for Generating or Transmitting Mechanical Vibrations of Infrasonic, Sonic, or Ultrasonic Frequency, for Performing Mechanical Work in General B06B 1/0607 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 41/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230051466 | Stepanova et al. |
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| FUNDED BY |
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| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anna Stepanova (Cary, North Carolina); Jose Alonso (Cary, North Carolina); Chengsong Zhao (Raleigh, North Carolina) |
| ABSTRACT | The invention relates to logic-gate-based Type II or Type V CRISPR-Cas constructs and methods for modifying gene expression using the CRISPR-Cas constructs and CRISPR-Cas effector proteins. |
| FILED | Friday, December 11, 2020 |
| APPL NO | 17/783786 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/63 (20130101) C12N 15/113 (20130101) C12N 15/905 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230051598 | Goldfarb et al. |
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| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Goldfarb (Nashville, Tennessee); Jantzen T. Lee (Nashville, Tennessee) |
| ABSTRACT | A method for detecting a user's intent in an adaptive lower limb device includes providing the adaptive lower limb device. The lower limb device includes a device control unit. The device control unit includes activity controllers and at least one accelerometer. The acceleration features are measured via the at least one accelerometer. The measured acceleration features are determined whether they correspond to a tapping movement initiated by a user with an intent to switch from a first one of the plurality of activity controllers to a second one of the plurality of activity controllers. If the measured accelerating features correspond to the tapping movement, the control unit of the adaptive lower limb device is switched from the first one of the activity controllers to the second one of the activity controllers. |
| FILED | Tuesday, February 16, 2021 |
| APPL NO | 17/797320 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/70 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230051993 | Xu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| INVENTOR(S) | Baoxing Xu (Charlottesville, Virginia); Yue Zhang (Philadelphia, Pennsylvania) |
| ABSTRACT | The capillary transfer technology presented here represents a powerful approach to transfer soft films from surface of liquid onto a solid substrate in a fast and defect-free manner. The fundamental theoretical model and transfer criteria validated with comprehensive experiments and finite element analyses, for the first time provides a quantitative guide and optimization for the choice of material systems, operating conditions and environments for scalable on-demand transfers with high yield. The intrinsically moderate capillary transfer force and externally selectable transfer direction offer robust capabilities for achieving deterministic assembly and surface properties of structures with complex layouts and patterns for potentially broad applications in the fabrication of flexible/stretchable electronics, surface wetting structures and optical devices. Integration of this technology with other advanced manufacturing technologies associated with material self-assembly, growth and layout alignment represents promising future topics and would help create emerging new manufacturing technologies that leverage unique fluidity of liquid environments. |
| FILED | Friday, November 20, 2020 |
| APPL NO | 17/793910 |
| CURRENT CPC | Producing Decorative Effects; Mosaics; Tarsia Work; Paperhanging B44C 1/1752 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 3/20 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230052931 | Han et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jung Han (New Haven, Connecticut); Rami Elafandy (Hamden, Connecticut) |
| ABSTRACT | III-Nitride layers having spatially controlled regions or domains of porosities therein with tunable optical, electrical, and thermal properties are described herein. Also disclosed are methods for preparing and using such III-nitride layers. |
| FILED | Monday, November 23, 2020 |
| APPL NO | 17/794511 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/26553 (20130101) Original (OR) Class H01L 29/2003 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/18361 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230052988 | Siskind et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana); NATIONAL UNIVERSITY OF IRELAND, MAYNOOTH (Maynooth, Ireland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey Mark Siskind (West Lafayette, Indiana); Barak Avrum Pearlmutter (Dublin, Ireland) |
| ABSTRACT | A system and method which allows the basic checkpoint-reverse-mode AD strategy (of recursively decomposing the computation to reduce storage requirements of reverse-mode AD) to be applied to arbitrary programs: not just programs consisting of loops, but programs with arbitrarily complex control flow. The method comprises (a) transforming the program into a formalism that allows convenient manipulation by formal tools, and (b) introducing a set of operators to allow computations to be decomposed by running them for a given period of time then pausing them, while treating the paused program as a value subject to manipulation. |
| FILED | Tuesday, August 09, 2022 |
| APPL NO | 17/818396 |
| CURRENT CPC | Electric Digital Data Processing G06F 7/60 (20130101) G06F 7/544 (20130101) G06F 9/461 (20130101) G06F 9/30036 (20130101) Original (OR) Class G06F 11/36 (20130101) G06F 17/10 (20130101) G06F 17/13 (20130101) G06F 17/17 (20130101) Computer Systems Based on Specific Computational Models G06N 5/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230053249 | LI et al. |
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| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Weigu LI (Austin, Texas); Donglei FAN (Austin, Texas) |
| ABSTRACT | Disclosed herein are dendritically porous three-dimensional structures, including hierarchical dendritically porous three-dimensional structures. The structures include metal foams and graphite structures, and are useful in energy storage devices as well as chemical catalysis. |
| FILED | Tuesday, August 09, 2022 |
| APPL NO | 17/883851 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) B82Y 40/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/205 (20170801) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/72 (20130101) C01P 2002/85 (20130101) C01P 2004/03 (20130101) C01P 2006/10 (20130101) C01P 2006/12 (20130101) C01P 2006/16 (20130101) C01P 2006/40 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/26 (20130101) Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 1/003 (20130101) C25D 1/006 (20130101) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/24 (20130101) H01G 11/36 (20130101) H01G 11/86 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230053327 | MacEwan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew R. MacEwan (St. Louis, Missouri); Jingwei Xie (St. Louis, Missouri); Zack Ray (St. Louis, Missouri); Younan Xia (St. Louis, Missouri) |
| ABSTRACT | A multi-laminar electrospun nanofiber scaffold for use in repairing a defect in a tissue substrate is provided. The scaffold includes a first layer formed by a first plurality of electrospun polymeric fibers, and a second layer formed by a second plurality of electrospun polymeric fibers. The second layer is combined with the first layer. A first portion of the scaffold includes a higher density of fibers than a second portion of the scaffold, and the first portion has a higher tensile strength than the second portion. The scaffold is configured to degrade via hydrolysis after at least one of a predetermined time or an environmental condition. The scaffold is configured to be applied to the tissue substrate containing the defect, and is sufficiently flexible to facilitate application of the scaffold to uneven surfaces of the tissue substrate, and to enable movement of the scaffold by the tissue substrate. |
| FILED | Friday, June 25, 2021 |
| APPL NO | 17/358463 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/02 (20130101) Original (OR) Class A61F 2/0063 (20130101) A61F 2/105 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 15/22 (20130101) A61L 15/42 (20130101) A61L 27/14 (20130101) A61L 27/50 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 48/05 (20190201) B29C 48/142 (20190201) Apparatus for Enzymology or Microbiology; C12M 25/14 (20130101) Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/0076 (20130101) D01D 5/0092 (20130101) Making Textile Fabrics, e.g From Fibres or Filamentary Material; Fabrics Made by Such Processes or Apparatus, e.g Felts, Non-woven Fabrics; Cotton-wool; Wadding D04H 1/728 (20130101) D04H 3/016 (20130101) D04H 3/073 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20230046609 | Cheng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Yang Cheng (Arcadia, California); Adnan I. Ansar (Granada Hills, California) |
| ABSTRACT | A method and hardware based system provide for descriptor-based feature mapping during terrain relative navigation (TRN). A first reference image/premade terrain map and a second image are acquired. Features in the first reference image and the second image are detected. A scale and an orientation of the one or more detected features are estimated based on an intensity centroid (IC), moments of the detected features, an orientation which is in turn based on an angle between a center of each of the detected features and the IC, and an orientation stability measure which is in turn based on a radius. Signatures are computed for each of the detected features using the estimated scale and orientation and then converted into feature descriptors. The descriptors are used to match features from the two images which are then used to perform TRN. |
| FILED | Tuesday, August 09, 2022 |
| APPL NO | 17/818634 |
| CURRENT CPC | Image or Video Recognition or Understanding G06V 10/24 (20220101) G06V 10/44 (20220101) G06V 10/98 (20220101) G06V 10/507 (20220101) Original (OR) Class G06V 10/771 (20220101) G06V 10/772 (20220101) G06V 10/7715 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230047323 | WANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chuanlong WANG (Hanover, New Hampshire); Weiyang LI (Hanover, New Hampshire) |
| ABSTRACT | The disclosure relates to metal phosphorothioates, batteries comprising metal phosphorothioate, cells comprising metal phosphorothioate, and methods of making thereof. |
| FILED | Thursday, December 31, 2020 |
| APPL NO | 17/790245 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/625 (20130101) H01M 4/5815 (20130101) Original (OR) Class H01M 10/0525 (20130101) H01M 10/0562 (20130101) H01M 2004/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230047661 | Radhakrishnan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Faraday Technology, Inc. (Englewood, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rajeswaran Radhakrishnan (Beavercreek, Ohio); Danny Xin Liu (Tipp City, Ohio); Dan Wang (Dublin, Ohio); Timothy D. Hall (Englewood, Ohio); Maria E. Inman (Yellow Springs, Ohio) |
| ABSTRACT | A method of coating a substrate includes adding ion erosion resistant particles, conductive particles, and a binder to an electrophoretic solution in an electrophoretic deposition apparatus including the substrate and a cathode spaced from the substrate. A current is applied to the substrate and cathode to deposit a first layer coating including the erosion resistant particles, the conductive particles, and the binder onto the substrate. The method further includes adding a low work function material to an electrolyte solution in an electrolytic deposition apparatus including the substrate and a cathode spaced from the substrate. A current is applied to the substrate and the cathode to deposit a second layer coating including the low work function material onto the substrate. |
| FILED | Friday, April 08, 2022 |
| APPL NO | 17/716621 |
| CURRENT CPC | Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/44 (20130101) Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 15/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230051079 | Bestul |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Science and Technology Corporation (Hampton, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kimberly A. Bestul (Cottonwood Heights, Utah) |
| ABSTRACT | A system for collecting atmospheric data includes a frame and sensors to include a sonic anemometer for measuring wind data samples in each of three dimensions, and motion sensors for measuring angles of roll motion, pitch motion and yaw motion of the sonic anemometer. A tether is coupled to a cable payout/retriever, a lighter-than-air balloon, and the frame such that the payout/retriever and balloon control movement of the frame through a region of an atmosphere. A processor receives the wind data samples and the sensed angles, and maps the wind data samples to a fixed local horizontal reference plane of the sonic anemometer that is normal to a local gravitational vector at the region of the atmosphere to generate samples of compensated data. The processor averages samples of compensated data to generate averaged compensated data that is indicative of wind speed and wind direction in the region of the atmosphere. |
| FILED | Friday, August 12, 2022 |
| APPL NO | 17/819424 |
| CURRENT CPC | Measuring Linear or Angular Speed, Acceleration, Deceleration, or Shock; Indicating Presence, Absence, or Direction, of Movement G01P 5/245 (20130101) Original (OR) Class G01P 13/025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230052509 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yifan Wang (Singapore, Singapore); Chiara Daraio (South Pasadena, California); Douglas C Hofmann (Altadena, California); Liuchi Li (Berkeley, California); Jose E Andrade (Pasadena, California) |
| ABSTRACT | A structure having a tunable modulus of bending (flexibility) composed of interlocking geometric particles arranged such that an external pressure/force causes them to jam together, increasing the stiffness of the overall structure. Methods for creating the external pressure can include the use of an envelope around the structure that can be evacuated of air. |
| FILED | Thursday, May 19, 2022 |
| APPL NO | 17/748626 |
| CURRENT CPC | Wall, Floor, or Like Covering Materials, e.g Linoleum, Oilcloth, Artificial Leather, Roofing Felt, Consisting of a Fibrous Web Coated With a Layer of Macromolecular Material; Flexible Sheet Material Not Otherwise Provided for D06N 7/00 (20130101) Original (OR) Class D06N 2209/103 (20130101) D06N 2209/128 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20230046953 | BANNANTINE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | INSTITUT PASTEUR (Paris Cedex 15, France); INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (NRA) (Paris Cedex 07, France); THE UNITED STATES OF AMERICA , AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John P. BANNANTINE (Ames, Iowa); Gilles ETIENNE (Toulouse, France); Sylvie BAY (Paris, France); Franck BIET (Notre Dame D'Oe, France) |
| ABSTRACT | The present invention is directed to an isolated synthetic tripeptide of formula H-D-Phe-N-Methyl-L-Val-L-Ala-OMe (SEQ ID NO:1), or a derivative thereof, and to the corresponding lipotripeptides, which are specific to Mycobacterium avium subsp. paratuberculosis (Map)S-type strain, as well as derivatives and conjugates thereof. The invention also concerns the use of these antigens in different methods and tests for detecting Map infection, especially by detecting humoral response and cell mediated response of infected animals. The invention is also directed to a genetic signature of Map and a mass spectrometry and NMR spectroscopy signature of Map presence or infection. |
| FILED | Friday, October 07, 2022 |
| APPL NO | 17/938865 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/04 (20130101) A61K 47/60 (20170801) A61K 47/542 (20170801) Peptides C07K 5/0812 (20130101) Original (OR) Class C07K 7/06 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5695 (20130101) G01N 2333/57 (20130101) G01N 2333/5428 (20130101) G01N 2469/20 (20130101) G01N 2800/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230048349 | CHU |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TEXAS A and M UNIVERSITY SYSTEM (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kung-Hui CHU (College Station, Texas) |
| ABSTRACT | The present disclosure provides a recirculating aquaculture system comprising a) a wastewater treatment system and b) a polyhydroxyalkanoate (PHA) production system. In particular, poly(3-hydroxybutyrate) (PHB) can be utilized as the PHA in such a system. Methods of treating wastewater for reuse by contacting the wastewater with one or more zeolites to remove material from the wastewater and reusing the treated wastewater are also provided as well as methods of producing a PHA such as PHB from organic waste. Moreover, food compositions comprising a PHA biomass as well as associated methods are also provided. |
| FILED | Tuesday, August 02, 2022 |
| APPL NO | 17/879326 |
| CURRENT CPC | Fodder A23K 10/18 (20160501) A23K 50/80 (20160501) Treatment of Water, Waste Water, Sewage, or Sludge C02F 3/107 (20130101) C02F 3/341 (20130101) Original (OR) Class C02F 2101/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230049275 | Gomelsky et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Wyoming (Laramie, Wyoming) |
| ASSIGNEE(S) | University of Wyoming (Laramie, Wyoming) |
| INVENTOR(S) | Mark Gomelsky (Laramie, Wyoming); Ahmed Elbakush (Tripoli, Libya) |
| ABSTRACT | Methods and compositions for inhibiting or dispersing biofilms produced by Listeria monocytogenes on plant matter are described. Embodiments include using formulations comprising active chemical constituents and aqueous extracts or sap from certain trees. Methods of using and producing aqueous formulations derived from hickory and maple wood are provided. Formulations and methods are provided for preventing and dispersing exopolysaccharide-rich listerial biofilms. |
| FILED | Monday, August 01, 2022 |
| APPL NO | 17/878517 |
| CURRENT CPC | Preserving, e.g by Canning, Meat, Fish, Eggs, Fruit, Vegetables, Edible Seeds; Chemical Ripening of Fruit or Vegetables; the Preserved, Ripened, or Canned Products A23B 7/16 (20130101) Original (OR) Class A23B 7/154 (20130101) Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 3/3463 (20130101) A23L 3/3508 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230050896 | Mis Solval et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Georgia Research Foundation, Inc. (Athens, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin Estuardo Mis Solval (Sharpsburg, Georgia); Peter George Chiarelli (Griffin, Georgia); Jinru Chen (Peachtree City, Georgia) |
| ABSTRACT | Provided are gelatin powders and gels derived from marine sources of collagen such as jellyfish. Also provided are methods for producing marine-derived gelatin powders. The marine-derived collagen source is hydrolyzed then dialyzed to at least partially demineralize the marine-derived collagen source. |
| FILED | Tuesday, August 02, 2022 |
| APPL NO | 17/879171 |
| CURRENT CPC | Derivatives of Natural Macromolecular Compounds C08H 1/06 (20130101) Original (OR) Class Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/12 (20130101) C08J 2489/04 (20130101) Compositions of Macromolecular Compounds C08L 89/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of the Interior (DOI)
| US 20230046530 | Robertson |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Bruce Robertson (Kingston, New York) |
| ASSIGNEE(S) | Bard College (Annadale-on-Hudson, New York) |
| INVENTOR(S) | Bruce Robertson (Kingston, New York) |
| ABSTRACT | An enhanced bird activity station that is more attractive to birds than conventional designs. The bird activity station is provided with a surface that is configured to horizontally polarize any light reflected by the surface. The bird activity station may be a bird feeder with a housing for containing bird food and a platform mounted to the housing. The platform forms the substrate that horizontally polarized the light reflected by the surface and is made from a transparent polymer and a layer of dark paint applied to an opposing side of the substrate from the housing. The bird activity station may also be a bird bath formed from a bowl having a layer of dark paint applied thereto so that any water placed in the bowl will cooperate with the layer of dark paint to horizontally polarize any light reflected by the surface. |
| FILED | Tuesday, August 03, 2021 |
| APPL NO | 17/392499 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 39/01 (20130101) A01K 45/002 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230049199 | McBride et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SRI International (Menlo Park, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sterling Eduardo McBride (Princeton, New Jersey); Joey J. Michalchuk (Lambertville, New Jersey); Seth Charles Caliga (Lafayette, Colorado); Alan M. Braun (Princeton, New Jersey) |
| ABSTRACT | The disclosure describes vacuum cell assemblies that integrate a vacuum envelope with a photonic integrated circuit (PIC). Walls of the vacuum envelope are coupled to the PIC, such as through anodic bonding, so that the PIC forms at least one wall of the vacuum envelope and provides an optically accessible medium and surface for transmitting and distributing light into various cavities of the vacuum envelope through one or more nonplanar waveguides. A surface of the PIC may include a material that is compatible with a material of the walls of the vacuum envelope, such as a silicon-based vacuum envelope bonded to a silicon nitride or amorphous silicon surface of the PIC. Each waveguide may include a bridge structure that forms a planar surface for tightly bonding with the vacuum envelope and preserves properties of the transmitted light between opposing sections of the waveguide. |
| FILED | Wednesday, October 07, 2020 |
| APPL NO | 17/758930 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/1228 (20130101) Original (OR) Class G02B 2006/12138 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20230049180 | BACALLAO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Indiana University Research and Technology Corporation (Indianapolis, Indiana); United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | Indiana University Research and Technology Corporation (Indianapolis, Indiana); United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | Robert BACALLAO (Indianapolis, Indiana); Simon ATKINSON (Carmel, Indiana); George RHODES (Fishers, Indiana); Peter CORRIDON (Indianapolis, Indiana) |
| ABSTRACT | The present invention provides methods and materials useful delivering liquids, including liquids comprising nucleic acid molecules into cells. In particular, the present invention provides methods for delivering saline solution, exogenous compositions, and isolated vectors to kidney cells, using the renal vein as a guide and under hydrodynamic pressure. The delivery methods and materials herein are useful to research, prognose, ameliorate symptoms of kidney injury, and treat kidney pathologies. |
| FILED | Thursday, July 07, 2022 |
| APPL NO | 17/859470 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 38/45 (20130101) A61K 38/443 (20130101) A61K 48/0058 (20130101) A61K 48/0075 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2710/10041 (20130101) Enzymes C12Y 101/01042 (20130101) C12Y 208/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Geospatial Intelligence Agency (NGA)
| US 20230050679 | RASHEED et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Novateur Research Solutions (Ashburn, Virginia) |
| ASSIGNEE(S) | Novateur Research Solutions (Ashburn, Virginia) |
| INVENTOR(S) | Zeeshan RASHEED (Great Falls, Virginia); Jonathan Jacob AMAZON (Haymarket, Virginia); Khurram HASSAN-SHAFIQUE (Aldie, Virginia) |
| ABSTRACT | A feature extractor and novel training objective are provided for content-based image retrieval. For example, a computer-implemented method includes applying a query image and a search image to a neural network of a feature extraction network of a computing device, the query image indicating an object to be searched for in the search image. The feature extraction network includes the neural network, a spatial feature neural network receiving a first output of the neural network pertaining to the search image, and an embedding network receiving a second output of the neural network pertaining to the query image. The method includes generating spatial search features from the spatial feature neural network, generating a query feature from the embedding network, applying the query feature to an artificial neural network (ANN) index, and determining an optimal matching result of an object in the search image based on an operation using the ANN index. |
| FILED | Friday, July 29, 2022 |
| APPL NO | 17/877415 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/51 (20190101) G06F 16/532 (20190101) Image or Video Recognition or Understanding G06V 10/82 (20220101) G06V 10/758 (20220101) G06V 10/7715 (20220101) Original (OR) Class G06V 10/7753 (20220101) G06V 20/10 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20230052083 | Yang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dongliang Yang (Ellicott City, Maryland); Phuc M. Nguyen (Merrifield, Virginia) |
| ABSTRACT | Devices and methods for quickly and accurately measuring the distance between two carriers of item processing equipment. The devices and methods can include an elongate bar and associated components which may increase the magnitude of lengths that can be measured. |
| FILED | Tuesday, August 09, 2022 |
| APPL NO | 17/818488 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 5/02 (20130101) Original (OR) Class G01B 5/0004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20230047286 | LEE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Won Kwang S and T Co., Ltd. (Incheon, South Korea) |
| ASSIGNEE(S) | |
| INVENTOR(S) | SANG HUN LEE (Incheon, South Korea); JUN KEE KIM (Seoul, South Korea); TAE EUN LEE (Incheon, South Korea); CHEONG MIN NOH (Incheon, South Korea); GEUN SIK CHO (Incheon, South Korea); SU HYON EOM (Incheon, South Korea) |
| ABSTRACT | A movable solar module disassembling apparatus according to an embodiment of the present disclosure includes a movable container unit that is hollow, can be moved by itself or by external power, and has at least one door being able to expose the inside by opening and closing, a frame separation unit that is disposed in the movable container unit, includes a frame separation blade pressing and separating the frame from the module body, is supplied with the solar module, and discharges the module body after separating the frame, and a disassembling unit that is disposed continuously with the frame separation unit in the movable container unit, includes a scrapper scraping and separating the stacked film from the glass plate, is supplied with the module body, and disassembles and discharges the module body into the stacked film and the glass plate. |
| FILED | Friday, November 05, 2021 |
| APPL NO | 17/519645 |
| CURRENT CPC | Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 10/40 (20141201) Original (OR) Class H02S 40/10 (20141201) H02S 40/38 (20141201) H02S 99/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230051103 | Roberts et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Andrew Roberts (Wellesley, Massachusetts); Aliasger Tayeb Zaidy (Seattle, Washington) |
| ABSTRACT | Various embodiments provide for one or more processor instructions and memory instructions that enable a memory sub-system to predict a schedule for migrating data between memory devices, which can be part of a memory sub-system. |
| FILED | Monday, August 16, 2021 |
| APPL NO | 17/403366 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/0604 (20130101) G06F 3/0647 (20130101) Original (OR) Class G06F 3/0673 (20130101) Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230051182 | LEE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Won Kwang S and T Co., Ltd. (Incheon, South Korea) |
| ASSIGNEE(S) | |
| INVENTOR(S) | SANG HUN LEE (Incheon, South Korea); JUN KEE KIM (Seoul, South Korea); TAE EUN LEE (Incheon, South Korea); CHEONG MIN NOH (Incheon, South Korea); GEUN SIK CHO (Incheon, South Korea); SU HYON EOM (Incheon, South Korea) |
| ABSTRACT | A solar module lifting apparatus includes a base supported on the ground, a cylinder module including cylinder units disposed on the base and changing in height by contracting and stretching, and a rotary supply plate having one side supporting a solar module and the other side coupled to the cylinder module and moving up and down the solar module by operation of the cylinder module, in which the rotary supply plate includes a first hinge and a second hinge spaced apart from each other on the other side, the cylinder module includes a first cylinder unit and a second cylinder unit of which the upper ends are coupled to the first hinge and the second hinge by shafts, respectively, and at least one of the height and the inclination of the rotary supply plate is adjusted by contracting or stretching of the first cylinder unit and the second cylinder unit. |
| FILED | Friday, November 05, 2021 |
| APPL NO | 17/519660 |
| CURRENT CPC | Disposal of Solid Waste B09B 3/00 (20130101) Transport or Storage Devices, e.g Conveyors for Loading or Tipping, shop Conveyor Systems Or pneumatic Tube Conveyors B65G 67/04 (20130101) Hoisting, Lifting, Hauling or Pushing, Not Otherwise Provided For, e.g Devices Which Apply a Lifting or Pushing Force Directly to the Surface of a Load B66F 9/0655 (20130101) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/4155 (20130101) G05B 2219/40034 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/18 (20130101) Original (OR) Class Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 30/10 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230052634 | Tomblin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wichita State University (Wichita, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John S. Tomblin (Wichita, Kansas); Waruna Seneviratne (Wichita, Kansas); Caleb Saathoff (Wichita, Kansas); John Matthew Tomblin (Wichita, Kansas); Christopher Pini (Wichita, Kansas) |
| ABSTRACT | An autonomous or semi-autonomous cell for inspecting composite parts, verifying repairs made to such parts, and facilitating repairs to composite parts. The cell employs automated inspection, damage assessment, and repair systems. An industrial robot automatically attaches to a set of interchangeable inspection and repair end effectors to carry out the inspection, verification, and repair processes. The cell can be equipped with fixtures for supporting a rotorcraft blade and rotating the blade within the cell so that the robot can access the entire blade. Processes are provided for performing inspections, tracking the inspection data for parts in a database, and carrying out repairs. Over time, a software applicant can use the inspection data to train a machine learning model for recognizing damage to the composite part based on inspection images. |
| FILED | Tuesday, May 31, 2022 |
| APPL NO | 17/828558 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 65/8253 (20130101) Original (OR) Class B29C 73/10 (20130101) B29C 73/26 (20130101) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2031/082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, February 16, 2023.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20230216.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page