FedInvent™ Patent Applications
Application Details for Thursday, February 23, 2023
This page was updated on Thursday, February 23, 2023 at 04:59 PM GMT
Department of Health and Human Services (HHS)
| US 20230053338 | Kagan |
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| FUNDED BY |
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| APPLICANT(S) | Children`s Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan C. Kagan (Brookline, Massachusetts) |
| ABSTRACT | The present invention provides methods and compositions for specific activation of inflammatory responses in dendritic cells (DCs). 1-palmitoyl-2-arachidonyl-sn-glycero phosphorylcholine (PAPC) and its oxidized variant (oxPAPC) were identified to promote DC-mediated immunity, and are provided as adjuvants in immunostimulatory compositions, including vaccines. |
| FILED | Monday, May 09, 2022 |
| APPL NO | 17/739953 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) Original (OR) Class A61K 2039/575 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230053353 | Mali et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Prashant Mali (La Jolla, California); Dhruva Katrekar (La Jolla, California); Thomas Morton (La Jolla, California) |
| ABSTRACT | The disclosure provides for a targeting transfer RNA (ttRNA) that that suppresses nonsense mutations in messenger RNA, that comprises an anticodon sequence that binds to a stop codon and a variable loop sequence that comprises an RNA aptamer that has strong binding affinity to an RNA binding protein; and methods of use thereof. |
| FILED | Friday, January 08, 2021 |
| APPL NO | 17/791498 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) Original (OR) Class C12N 15/63 (20130101) C12N 15/1024 (20130101) C12N 2310/16 (20130101) C12N 2310/122 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230053360 | Stephanopoulos et al. |
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| FUNDED BY |
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| APPLICANT(S) | Nicholas Stephanopoulos (Scottsdale, Arizona); Tara MacCulloch (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas Stephanopoulos (Scottsdale, Arizona); Tara MacCulloch (Scottsdale, Arizona) |
| ABSTRACT | The present disclosure relates to nucleic acid-peptide-nucleic acid conjugate molecules and to methods for synthesizing nucleic acid-peptide-nucleic acid conjugate molecules. In some embodiments, a method for synthesizing a nucleic acid-peptide-nucleic acid conjugate molecule using proximity-enhanced synthesis includes covalently linking a peptide with a first nucleic acid strand via a first reaction, hybridizing the first nucleic acid strand with a second nucleic acid strand to bring the second nucleic acid strand in proximity to the peptide, and covalently linking the peptide with the second nucleic acid strand via a second reaction to provide the nucleic acid-peptide-nucleic acid conjugate molecule. In some embodiments, the peptide of the nucleic acid-peptide-nucleic acid conjugate molecule is a substrate for cleavage by an enzyme, such as matrix metalloproteinase-8 (MMP-8). Exemplary applications of the nucleic acid-peptide-nucleic acid conjugate molecule for drug delivery, molecular assembly of hybrid structures, and constraining the peptide to a biologically active conformation are also disclosed. |
| FILED | Wednesday, August 10, 2022 |
| APPL NO | 17/818856 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/64 (20170801) A61K 47/549 (20170801) A61K 47/6925 (20170801) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2310/18 (20130101) C12N 2310/3513 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230053434 | Malyarenko et al. |
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| FUNDED BY |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dariya I. Malyarenko (Ann Arbor, Michigan); Scott D. Swanson (Ann Arbor, Michigan); Thomas L. Chenevert (Ann Arbor, Michigan) |
| ABSTRACT | Methods and systems are provided for analyzing diffusion weighted images (DWI) using impeded diffusion fraction models for quantitative imaging diagnostic assay of cancer, such as glandular tissue cancers. The Impeded diffusion fraction models are tissue and cancer independent and generate a single score representative of multi-compartment diffusion fractions occurring within each voxel of a DWI image. |
| FILED | Thursday, August 11, 2022 |
| APPL NO | 17/886027 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4842 (20130101) A61B 5/4848 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/56341 (20130101) Image Data Processing or Generation, in General G06T 7/0016 (20130101) Original (OR) Class G06T 2207/10088 (20130101) G06T 2207/30068 (20130101) G06T 2207/30081 (20130101) G06T 2207/30096 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230053493 | Kleinfeld et al. |
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| FUNDED BY |
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| APPLICANT(S) | Alan Marc Kleinfeld (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alan Marc Kleinfeld (La Jolla, California); Andrew H. Huber (La Jolla, California); Hiroto Kameyama (La Jolla, California); Tung-Chih Sun (La Jolla, California); Divya Subramonian (La Jolla, California) |
| ABSTRACT | Identification and use of proteins fluorescently labeled and that undergo a change in fluorescence index upon binding bilirubin are described. Probes are disclosed which are labeled at a cysteine or lysine residue and also probes labeled at both cysteine and lysine with two different fluorophores. These probes are useful for determination of unbound bilirubin levels in a fluid sample. |
| FILED | Thursday, August 27, 2020 |
| APPL NO | 17/632202 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/72 (20130101) Original (OR) Class G01N 33/582 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230053540 | Shalek et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander K. Shalek (Cambridge, Massachusetts); Kellie Elizabeth Kolb (Cambridge, Massachusetts); Chad Walesky (Boston, Massachusetts); Wolfram Goessling (Boston, Massachusetts) |
| ABSTRACT | A method of treating an injury in an organ or tissue includes administering to a subject in need thereof an agent that modulates expression and/or activity of one or more genes involved in the regeneration and functional compensation of the tissue or organ in response to the injury. |
| FILED | Wednesday, February 19, 2020 |
| APPL NO | 17/431835 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/005 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) C12N 15/111 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230053555 | Graham et al. |
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| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| INVENTOR(S) | Barney Graham (Smyrna, Georgia); Guillaume Stewart-Jones (Cambridge, Massachusetts); Rebecca J. Loomis (Philadelphia, Pennsylvania) |
| ABSTRACT | Embodiments of immunogens comprising a recombinant Mumps (MuV) F ectodomain trimer stabilized in a prefusion conformation or a recombinant Measles (MeV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also provided are embodiments of immunogens comprising chimeric proteins comprising the recombinant MuV or MeV F ectodomain trimer and one or more MuV HN or MeV H ectodomains. Also disclosed are nucleic acids encoding the immunogens and methods of their production. Methods for inducing an immune response in a subject by administering a disclosed immunogen to the subject are also provided. In some embodiments, the immune response treats or inhibits MuV and/or MeV infection in a subject. |
| FILED | Friday, December 11, 2020 |
| APPL NO | 17/784605 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/165 (20130101) Original (OR) Class A61K 2039/575 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230053658 | Maron et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Brigham and Women`s Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bradley A. Maron (Sharon, Massachusetts); Andriy Samokhin (Stoughton, Massachusetts); George A. Alba (Boston, Massachusetts) |
| ABSTRACT | Aspects of the present disclosure relate to methods for detecting neural precursor cell expressed developmentally down-regulated protein 9 (NEDD9) in a sample from a subject having or at risk for pulmonary hypertension (PH), wherein pulmonary hypertension (PH) is selected from the group consisting of pulmonary arterial hypertension (PAH), chronic thromboembolic pulmonary hypertension (CTEPH), and pulmonary hypertension (PH) due to acute respiratory distress syndrome (ARDS). |
| FILED | Wednesday, December 23, 2020 |
| APPL NO | 17/789013 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) Original (OR) Class G01N 2800/321 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230053681 | Vilen |
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| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Barbara Vilen (Chapel Hill, North Carolina) |
| ABSTRACT | The present invention provides compositions comprising molecules having multispecificity and method of their use. |
| FILED | Tuesday, January 11, 2022 |
| APPL NO | 17/573145 |
| CURRENT CPC | Peptides C07K 16/283 (20130101) C07K 16/468 (20130101) Original (OR) Class C07K 2317/31 (20130101) C07K 2317/55 (20130101) C07K 2317/62 (20130101) C07K 2317/64 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230053684 | Cowman et al. |
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| FUNDED BY |
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| APPLICANT(S) | New York University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mary K. Cowman (Mohegan Lake, New York); Fok Vun Chan (Salt Lake City, Utah) |
| ABSTRACT | The present disclosure provides a facile method for selective isolation of hyaluronan (HA) from fluids and tissues by adsorption to a solid matrix. The method involves the use of specific solvent conditions and solid phase media favoring binding and subsequent elution of HA ranging in size from about 10 kDa to several MDa, while allowing separation of HA from other biological polyanions such as nucleic acids, sulfated glycosaminoglycans, chondroitin, and heparosan. |
| FILED | Monday, August 15, 2022 |
| APPL NO | 17/819680 |
| CURRENT CPC | Polysaccharides; Derivatives Thereof C08B 37/0072 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/405 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230053685 | Chen et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEE OF THE STEVES INSTITUTE OF TECHNOLOGY (Hoboken, New Jersey); RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (New Brunswick, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yingying Chen (Morganville, New Jersey); Jie Yang (Tallahassee, Florida); Yan Wang (Jersey City, New Jersey); Jian Liu (Jersey City, New Jersey); Marco Gruteser (Princeton, New Jersey) |
| ABSTRACT | A system includes a device that is disposed within an environment and is adapted to communicate over a radio frequency communication link. The system also includes a wireless access point disposed within the environment, including a wireless transceiver in communication with the device over a radio frequency communication link using a plurality of channels, and recording a channel state information data set for the radio frequency communication link. The system also includes a monitoring device including a memory storing a plurality of activity profiles, each of which includes an activity and a channel state information profile corresponding to the activity, and a processor receiving, from the wireless access point, the channel state information data set and determining, based on a comparison of the channel state information data set to the channel state information profile of each of the plurality of activity profiles, the activity of the person in the environment. |
| FILED | Friday, August 19, 2022 |
| APPL NO | 17/892004 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 67/306 (20130101) Original (OR) Class Wireless Communication Networks H04W 4/027 (20130101) H04W 4/029 (20180201) H04W 4/30 (20180201) H04W 88/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230053688 | Roth et al. |
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| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lisa G. Roth (Scarsdale, New York); Ethel Cesarman (Jersey City, New Jersey) |
| ABSTRACT | Methods of altering viral latency, sensitizing EBV+ tumors, or modulating viral immunogenicity, are provided. |
| FILED | Friday, January 08, 2021 |
| APPL NO | 17/791754 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/706 (20130101) Original (OR) Class A61K 39/245 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/22 (20180101) A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2710/16234 (20130101) C12N 2710/16271 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/502 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230053714 | Marshall et al. |
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| FUNDED BY |
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| APPLICANT(S) | Calder Biosciences Inc. (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Marshall (New York, New York); Mark Yondola (New York, New York); Roberto Mariani (New York, New York); Aaron Zomback (Cheshire, Connecticut); Sonal Gidwani (New York, New York) |
| ABSTRACT | The present invention provides mutant RSV F molecules, such as those that can be, or are stabilized, in a pre-fusion conformation by the introduction of one or more DT cross-links. The present invention also provides methods of making such mutant RSV F molecules, compositions comprising such mutant RSV F molecules, and methods of use of such mutant RSV F molecules, for example in vaccination methods, therapeutic methods, and antibody production methods. |
| FILED | Wednesday, February 09, 2022 |
| APPL NO | 17/668287 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/155 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2760/18522 (20130101) C12N 2760/18534 (20130101) C12N 2760/18571 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230053808 | LOCKLIN et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Georgia Research Foundation, Inc. (Athens, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason J. LOCKLIN (Bogart, Georgia); Qiaohong LIU (Athens, Georgia); Priyadarshini SINGHA (Athens, Georgia); Hitesh HANDA (Athens, Georgia); Jitendra PANT (Athens, Georgia); Marcus J. GOUDIE (Athens, Georgia); Sean P. HOPKINS (Athens, Georgia) |
| ABSTRACT | Coating compositions, coated articles including the coating compositions, and methods of making the coating compositions and coated articles are provided. In some aspects, the coating compositions are applied to a substrate having nitric oxide-releasing properties. The coating compositions can include copolymers having crosslinking agents that can be activated with mild UV light (about 345 nm to 365 nm) to avoid damaging the substrate while creating strong covalent bonds to the substrate. The copolymers can include hydrophilic repeat units, and in particular zwitterionic repeat units such as repeat units containing phosphorylcholine groups. In some aspects, the coating compositions are applied to a surface of a polymer substrate, wherein the polymer substrate had nitric oxide releasing properties. The coating compositions and the coated articles can have antifouling, antithrombotic, and/or antibacterial properties. |
| FILED | Friday, May 13, 2022 |
| APPL NO | 17/663296 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/197 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 29/16 (20130101) A61L 29/085 (20130101) A61L 2300/21 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 133/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230053864 | Isom et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Miami (Miami, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Isom (Miami, Florida); William Morgan (Miaimi, Florida); Nicholas Kapolka (Miami, Florida); Geoffrey Taghon (Miami, Florida); Jacob Rowe (Miami, Florida) |
| ABSTRACT | The disclosure relates to a plurality of cells, compositions and methods for identifying modulators of a target protein. The cells, compositions and methods comprise a (i) a target domain gene (ii) an intracellular chimeric G-protein alpha subunit comprising an endogenous G-protein alpha subunit with a humanized C-terminus; and (iii) an inducible reporter, wherein the expression of the reporter is dependent on the activation of the target domain encoded by target domain gene, and wherein the target domain gene comprises a barcode. The disclosure further relates to a host cell comprising a plurality of exogenous landing pads integrated in the host cell's genome, wherein each exogenous landing pad is integrated at a safe harbor genome loci in the host cell's genome. |
| FILED | Wednesday, December 16, 2020 |
| APPL NO | 17/785524 |
| CURRENT CPC | Peptides C07K 14/705 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/905 (20130101) C12N 2310/20 (20170501) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6872 (20130101) Original (OR) Class G01N 2500/04 (20130101) G01N 2500/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230053915 | Yeo et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eugene Yeo (La Jolla, California); Kristopher Brannan (La Jolla, California); Ryan Marina (La Jolla, California); David Nelles (La Jolla, California) |
| ABSTRACT | Disclosed herein is a technology to perform programmable RNA editing at single-nucleotide resolution using RNA-targeting CRISPR/Cas9. This approach, which Applicants have termed “Cas9-directed RNA editing” or “CREDIT,” provides a means to reversibly alter genetic information in a temporal manner, unlike traditional CRISPR/Cas9 driven genomic engineering which relies on permanently altering DNA sequence. |
| FILED | Monday, July 11, 2022 |
| APPL NO | 17/811626 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/85 (20130101) Original (OR) Class C12N 15/113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230054039 | Guan et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Cincinnati (Cincinnati, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jun-Lin Guan (Cincinnati, Ohio); Mingang Hao (Cincinnati, Ohio) |
| ABSTRACT | A method of treating human epidermal growth factor receptor 2 (HER2)-positive breast cancer in a subject in need thereof is provided, including administering to the subject an effective amount of a therapeutic agent that inhibits a nucleic acid that encodes FAK family-interacting protein of 200 kDa (FIP200). Also provided is a method of inhibiting metastasis of human epidermal growth factor receptor 2 (HER2)-positive breast cancer in a subject. |
| FILED | Thursday, July 28, 2022 |
| APPL NO | 17/815849 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7105 (20130101) Original (OR) Class A61K 38/465 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230054313 | Jagadeeswaran |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF NORTH TEXAS (Denton, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pudur Jagadeeswaran (Denton, Texas) |
| ABSTRACT | In alternative embodiments, provided are compositions, including products of manufacture and kits, and methods, for preventing thrombotic episodes such as venous thrombosis in patients at risk, which include estrogen-treated individuals and patients with breast cancer and lung cancer, or any individual having reduced levels of TFPI protein. |
| FILED | Friday, July 15, 2022 |
| APPL NO | 17/866437 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230054318 | Zhuang et al. |
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| FUNDED BY |
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| APPLICANT(S) | NE1 Inc. (New York, New York); NATIONAL INSTITUTE OF HEALTH (Bethesda, Maryland); University of South Bohemia in Ceske Budejovice (Ceske Budejovice, Czech Republic) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhengping Zhuang (Bethesda, Maryland); Rogelio Medina (Downey, California); Herui Wang (Mclean, Virginia); Jan Zenka (Ceské Budejovice, Czech Republic); Karel Pacak (Bethesda, Maryland); Winson Ho (Austin, Texas) |
| ABSTRACT | Disclosed herein is a personalized tumor vaccine comprising attenuated cancer cells and a method of using said personalized tumor vaccine to treat cancer. |
| FILED | Friday, December 11, 2020 |
| APPL NO | 17/783866 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) Original (OR) Class A61K 39/39 (20130101) A61K 39/3955 (20130101) A61K 2039/5152 (20130101) A61K 2039/55561 (20130101) A61K 2039/55572 (20130101) A61K 2039/55583 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2878 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230054335 | Macias et al. |
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| FUNDED BY |
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| APPLICANT(S) | Platelet Biogenesis, Inc. (Watertown, Massachusetts) |
| ASSIGNEE(S) | Platelet Biogenesis, Inc. (Watertown, Massachusetts) |
| INVENTOR(S) | Jorge Luis Valdez Macias (Watertown, Massachusetts); Marcus Lehmann (Watertown, Massachusetts); Jonathan N. Thon (Watertown, Massachusetts); Douglas G. Savin (Watertown, Massachusetts) |
| ABSTRACT | There is provided a method of making a fluidic system that comprises assembling a fluidic system comprising a first plate, a second plate and a membrane disposed between the first plate and the second plate; applying laser energy to the fluidic system to cause the first plate, the second plate and the membrane to melt at bonding areas; and allowing the bonding areas to cool down such that the first plate, the second plate and the membrane are bonded together. |
| FILED | Friday, August 19, 2022 |
| APPL NO | 17/891306 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502707 (20130101) Original (OR) Class B01L 2300/0681 (20130101) B01L 2300/0816 (20130101) B01L 2300/0864 (20130101) B01L 2300/0867 (20130101) B01L 2300/0887 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 65/1635 (20130101) B29C 65/1696 (20130101) B29C 66/244 (20130101) B29C 66/1142 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230054375 | LIU |
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| FUNDED BY |
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| APPLICANT(S) | THE UAB RESEARCH FOUNDATION (Birmingham, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaoguang Margaret LIU (Vestavia Hills, Alabama) |
| ABSTRACT | Disclosed herein is an antibody that selectively binds CD47 on tumor cells. Also disclosed is a method for treating cancer in a subject, comprising administering to the subject an effective amount of the antibody disclosed herein. |
| FILED | Thursday, August 04, 2022 |
| APPL NO | 17/817448 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6849 (20170801) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2803 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230054471 | Scharenberg et al. |
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| FUNDED BY |
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| APPLICANT(S) | Seattle Children's Hospital (dba Seattle Children's Research Institute) (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew M. Scharenberg (Seattle, Washington); Kyle Jacoby (Seattle, Washington); Alexandra E. Grier (Seattle, Washington) |
| ABSTRACT | Disclosed herein are polynucleotides having a plurality of thymine nucleotides and an endonuclease recognition site inserted therein, methods of engineering the polynucleotides having a plurality of thymine nucleotides and an endonuclease recognition site inserted therein, and methods of enhancing transcription, translation, and increasing stability of a polynucleotide. |
| FILED | Monday, July 11, 2022 |
| APPL NO | 17/811685 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 41/0047 (20130101) A61K 48/0066 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) C12N 15/67 (20130101) C12N 2710/10343 (20130101) C12N 2750/14143 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230054899 | ZHANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | William Marsh Rice University (Houston, Texas) |
| ASSIGNEE(S) | William Marsh Rice University (Houston, Texas) |
| INVENTOR(S) | David Yu ZHANG (Houston, Texas); Ping SONG (Houston, Texas); Omid VEISEH (Houston, Texas); Siavash PARKHIDEH (Houston, Texas); Sudip MUKHERJEE (Houston, Texas); Maria Isabel RUOCCO (Houston, Texas); Boram KIM (Houston, Texas); Yuxuan CHENG (Houston, Texas) |
| ABSTRACT | Provided herein are high-throughput methods for genetic barcoding and analysis, e.g., for tagging each biomaterial apsule with a barcode cell. These barcode cells are derived from patient samples, and thus embody natural human genetic variation. Also provided are SNP panels that can be used as genetic barcodes to identify the identity of a cell. |
| FILED | Thursday, January 14, 2021 |
| APPL NO | 17/758828 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5036 (20130101) A61K 35/39 (20130101) A61K 49/0008 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0012 (20130101) Original (OR) Class C12N 15/1065 (20130101) C12N 2503/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230054956 | CROWE, Jr. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James E. CROWE, Jr. (Nashville, Tennessee) |
| ABSTRACT | The present disclosure is directed to antibodies binding to and neutralizing norovirus and methods for use thereof. |
| FILED | Monday, June 20, 2022 |
| APPL NO | 17/807773 |
| CURRENT CPC | Peptides C07K 16/1009 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/33 (20130101) C07K 2317/76 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) G01N 2333/085 (20130101) G01N 2469/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230055137 | JOHNSON, JR. et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alan T. JOHNSON, JR. (Philadelphia, Pennsylvania); Jinglei PING (Gaithersburg, Maryland); Ramya VISHNUBHOTLA (Philadelphia, Pennsylvania) |
| ABSTRACT | Provided are devices and methods for detecting a target molecule, based on using a graphene electrode. The devices exhibit high sensitivity to target molecules such as DNA that may be present at comparatively low concentrations. |
| FILED | Thursday, September 22, 2022 |
| APPL NO | 17/934540 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 15/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/327 (20130101) Original (OR) Class G01N 27/4146 (20130101) G01N 33/5438 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230055337 | Lim et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wendell A. Lim (San Francisco, California); Milos Simic (San Francisco, California); Hideho Okada (San Francisco, California); Joseph H. Choe (San Francisco, California); Payal B. Watchmaker (San Francisco, California) |
| ABSTRACT | Provided herein is a cell comprising a recombinant nucleic acid encoding a transmembrane protein that has an extracellular binding domain that specifically binds to a brain-selective extracellular antigen, e.g., MOG, CDH10, PTPRZ1 or NRCAM, wherein the cell does not comprise a nucleic acid encoding an antigen-specific therapeutic that binds to a killing antigen expressed by a glioblastoma. |
| FILED | Friday, November 06, 2020 |
| APPL NO | 17/792385 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) A61P 35/00 (20180101) Peptides C07K 14/7051 (20130101) C07K 16/28 (20130101) C07K 16/40 (20130101) C07K 16/2803 (20130101) Original (OR) Class C07K 2319/03 (20130101) C07K 2319/71 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230055740 | Wick et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CAMERAD TECHNOLOGIES (Decatur, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carson A. Wick (Decatur, Georgia); Srini Tridandapani (Decatur, Georgia) |
| ABSTRACT | Methods for co-registering images of different imaging modalities include obtaining a photograph and a medical image, maximizing mutual information between the photograph and the medical image, automatically locating features common to both the photograph and the medical image based on maximized mutual information between the photograph and the medical image, and automatically highlighting the located features within the photograph or medical image. |
| FILED | Friday, September 09, 2022 |
| APPL NO | 17/942052 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230055790 | BLACK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MASSACHUSETTS EYE AND EAR INFIRMARY (Boston, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicole Leah BLACK (Cambridge, Massachusetts); Emily DAVIDSON (Cambridge, Massachusetts); Jennifer A. LEWIS (Cambridge, Massachusetts); Aaron Kyle REMENSCHNEIDER (Boston, Massachusetts); Elliott D. KOZIN (Boston, Massachusetts) |
| ABSTRACT | Described herein are melt-extrudable biodegradable inks for 3D-printing, methods of using the inks, and kits including the inks, to prepare implantable grafts, such as artificial tympanic membrane devices or artificial cartilage, nerve conduit, tendon, muscle tissue, or bone devices. |
| FILED | Friday, December 11, 2020 |
| APPL NO | 17/784346 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) Original (OR) Class A61L 2430/14 (20130101) Compositions of Macromolecular Compounds C08L 75/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230055805 | Bazin-Lee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | INIMMUNE CORPORATION (Missoula, Montana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Helene Bazin-Lee (Stevensville, Montana); George Ettenger (Missoula, Montana); Juhienah Khalaf (Hamilton, Montana); Kendal T. Ryter (Hamilton, Montana) |
| ABSTRACT | Toll-like receptor (TLR) ligands having an allose-based core are stable in aqueous formulation and are useful in treating, preventing, or reducing susceptibility to diseases or conditions mediated by TLRs, such as cancer, infectious disease, allergy, autoimmune disease, sepsis, and ischemia reperfusion. |
| FILED | Monday, August 29, 2022 |
| APPL NO | 17/898165 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7008 (20130101) Original (OR) Class A61K 39/35 (20130101) A61K 39/39 (20130101) A61K 45/06 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 15/12 (20130101) C07H 15/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230055832 | Guo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Jia Guo (Tempe, Arizona); Joshua LaBaer (Chandler, Arizona); Christopher Nazaroff (New Market, Maryland); Thai Pham (Tempe, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jia Guo (Tempe, Arizona); Joshua LaBaer (Chandler, Arizona); Christopher Nazaroff (New Market, Maryland); Thai Pham (Tempe, Arizona) |
| ABSTRACT | Provided herein are methods for multiplexed in situ analysis of biomolecules in a tissue. In particular, provided herein are methods for multiplexed single-cell in situ protein and nucleic acid profiling in fixed or fresh tissues, and also allows the investigation of the different cell compositions and their spatial organizations in intact tissues through consecutive cycles of probe hybridization, fluorescence imaging, and signal removal. |
| FILED | Thursday, July 28, 2022 |
| APPL NO | 17/876107 |
| CURRENT CPC | Heterocyclic Compounds C07D 209/08 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/582 (20130101) Original (OR) Class G01N 33/6803 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230055979 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lihong Wang (Arcadia, California); Rui Cao (Pasadena, California) |
| ABSTRACT | Methods, devices, apparatus, and systems for three-dimensional (3D) contoured scanning photoacoustic imaging and/or deep learning virtual staining. |
| FILED | Wednesday, August 17, 2022 |
| APPL NO | 17/820496 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/1702 (20130101) Original (OR) Class G01N 2021/1706 (20130101) G01N 2021/1772 (20130101) G01N 2201/067 (20130101) G01N 2201/106 (20130101) G01N 2201/127 (20130101) Image or Video Recognition or Understanding G06V 20/69 (20220101) Pictorial Communication, e.g Television H04N 13/15 (20180501) H04N 13/254 (20180501) H04N 13/271 (20180501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230056047 | DESIMONE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph DESIMONE (Chapel Hill, North Carolina); Joel TEPPER (Chapel Hill, North Carolina); James BYRNE (Chapel Hill, North Carolina) |
| ABSTRACT | A method and system for combination therapy utilizing local drug delivery and radiotherapy at a target site of body tissue are provided. The delivery system comprises a source electrode adapted to be positioned proximate to a target site of internal body tissue. A counter electrode is in electrical communication with the source electrode, and is configured to cooperate with the source electrode to form a localized electric field proximate to the target site. A cargo may be delivered to the target site when exposed to the localized electric field. Radiotherapy is applied to the target site in combination with the local drug delivery. |
| FILED | Monday, June 06, 2022 |
| APPL NO | 17/832804 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/007 (20130101) A61M 37/00 (20130101) A61M 2037/0007 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/327 (20130101) A61N 1/0509 (20130101) A61N 5/10 (20130101) A61N 5/1007 (20130101) A61N 5/1077 (20130101) Original (OR) Class A61N 2005/1098 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230056088 | CRAWLEY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Adrian P. CRAWLEY (Toronto, Canada); Rohan DHARMAKUMAR (Moorpark, California); James DUFFIN (Toronto, Canada); Joseph Arnold FISHER (Thornhill, Canada); David MIKULIS (Oakville, Canada); Julien POUBLANC (Toronto, Canada); Behzad SHARIF (Los Angeles, California); Olivia SOBCZYK (Etobicoke, Canada); Kamil ULUDAG (Toronto, Canada); Chau VU (Los Angeles, California); John WOOD (Los Angeles, California); Hsin-Jung YANG (Oakville, Canada) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adrian P. CRAWLEY (Toronto, Canada); Rohan DHARMAKUMAR (Moorpark, California); James DUFFIN (Toronto, Canada); Joseph Arnold FISHER (Thornhill, Canada); David MIKULIS (Oakville, Canada); Julien POUBLANC (Toronto, Canada); Behzad SHARIF (Los Angeles, California); Olivia SOBCZYK (Etobicoke, Canada); Kamil ULUDAG (Toronto, Canada); Chau VU (Los Angeles, California); John WOOD (Los Angeles, California); Hsin-Jung YANG (Oakville, Canada) |
| ABSTRACT | Deoxyhemoglobin in a subject may be modulated to act as a contrast agent for use in magnetic resonance imaging. Sequential gas delivery may be applied to adjust the level of deoxyhemoglobin in the subject. A suitable magnetic resonance imaging (MRI) pulse sequence that is sensitive to magnetic field inhomogeneities, such as a blood-oxygen-level dependent (BOLD) sequence, may be used to detect deoxyhemoglobin as a contrast agent. |
| FILED | Thursday, December 31, 2020 |
| APPL NO | 17/789732 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0044 (20130101) A61B 5/055 (20130101) A61B 5/0263 (20130101) A61B 5/7257 (20130101) A61B 5/7289 (20130101) A61B 5/14542 (20130101) A61B 5/14546 (20130101) A61B 2560/0223 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/50 (20130101) G01R 33/58 (20130101) G01R 33/281 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230056135 | Schinazi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | Emory University (Atlanta, Georgia) |
| INVENTOR(S) | Raymond F. Schinazi (Miami, Florida); Franck Amblard (Tucker, Georgia); Bryan Cox (Suwanee, Georgia); Che Chen (Decatur, Georgia); Leda Bassit (Smyrna, Georgia) |
| ABSTRACT | The present invention is directed to compounds, compositions and methods for preventing, treating or curing hepatitis B (HBV) infection in human subjects or other animal hosts. The compounds are as also pharmaceutically acceptable, salts, prodrugs, and other derivatives thereof as pharmaceutical compositions and methods for treatment, prevention or eradication of HBV infection. |
| FILED | Friday, October 04, 2019 |
| APPL NO | 17/281940 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Heterocyclic Compounds C07D 207/22 (20130101) Original (OR) Class C07D 249/04 (20130101) C07D 401/04 (20130101) C07D 401/14 (20130101) C07D 403/12 (20130101) C07D 417/04 (20130101) C07D 417/14 (20130101) C07D 471/04 (20130101) C07D 471/18 (20130101) C07D 487/04 (20130101) C07D 498/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230056189 | Liedtke et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wolfgang Liedtke (Durham, North Carolina); Ru-Rong Ji (Durham, North Carolina) |
| ABSTRACT | The present disclosure describes, in part, compositions and methods for treating pathologic pains associated with malignant growth disorders by administering a therapeutically effective amount of K+/Cl-cotransporter (Kcc2/KCC2) gene expression enhancer to a subject in need. |
| FILED | Thursday, March 18, 2021 |
| APPL NO | 17/912429 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/17 (20130101) A61K 31/55 (20130101) Original (OR) Class A61K 31/166 (20130101) A61K 31/167 (20130101) A61K 31/337 (20130101) A61K 31/365 (20130101) A61K 31/428 (20130101) A61K 31/475 (20130101) A61K 31/519 (20130101) A61K 31/704 (20130101) A61K 31/7048 (20130101) A61K 31/7068 (20130101) A61K 33/243 (20190101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230056283 | STEWART |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF UTAH RESEARCH FOUNDATION (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Russell J. STEWART (Salt Lake City, Utah) |
| ABSTRACT | Described herein are fluid complex coacervates that produce solid adhesives in situ. Oppositely charged polyelectrolytes were designed to form fluid adhesive complex coacervates at ionic strengths higher than the ionic strength of the application site, but an insoluble adhesive solid or gel at the application site. When the fluid, high ionic strength adhesive complex coacervates are introduced into the lower ionic strength application site, the fluid complex coacervate is converted to a an adhesive solid or gel as the salt concentration in the complex coacervate equilibrates to the application site salt concentration. In one embodiment, the fluid complex coacervates are designed to solidify in situ at physiological ionic strength and have numerous medical applications. In other aspects, the fluid complex coacervates can be used in aqueous environment for non-medical applications. |
| FILED | Monday, September 12, 2022 |
| APPL NO | 17/931242 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/0043 (20130101) A61K 49/0054 (20130101) A61K 49/0073 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 24/02 (20130101) A61L 24/10 (20130101) A61L 24/0015 (20130101) A61L 24/0031 (20130101) A61L 24/0042 (20130101) A61L 24/043 (20130101) A61L 24/046 (20130101) Original (OR) Class A61L 24/104 (20130101) A61L 2300/44 (20130101) A61L 2300/416 (20130101) A61L 2430/02 (20130101) A61L 2430/36 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/1668 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230056497 | Calvo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, As Represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Raul Rolando Calvo (Rockville, Maryland); Bolormaa Baljinnyam (Rockville, Maryland); Andres Eduardo Dulcey (Rockville, Maryland); Udo Rudloff (Bethesda, Maryland); Mark James Henderson (Bethesda, Maryland); Juan Jose Marugan (Bethesda, Maryland); Xin Hu (Bethesda, Maryland); Noel Terrence Southall (Bethesda, Maryland); Rushikesh Vilas Sable (Bethesda, Maryland) |
| ABSTRACT | Compounds of Formula I, Formula II, and Formula III and the pharmaceutically acceptable salts thereof are disclosed. The variables X, a, b, c, d, R1-4, R10-15 and R17-22 are disclosed herein. The compounds are useful for treating cancer disorders, especially those involving M2 phenotype of macrophages. Pharmaceutical compositions containing compounds of Formula I or Formula II or Formula III and methods of treatment comprising administering compounds of Formula I and Formula II and Formula III are also disclosed. |
| FILED | Wednesday, December 16, 2020 |
| APPL NO | 17/787313 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 307/80 (20130101) C07D 471/04 (20130101) C07D 487/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230056533 | Singec et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States o fAmerica, as represented by the Secretary, Dept. of Health and Human Services (Bethesd, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ilyas Singec (Gaithersburg, Maryland); Vukasin Jovanovic (Rockville, Maryland); Anton Simeonov (Bethesda, Maryland) |
| ABSTRACT | Methods for generating multipotent radial glia-like cells and astrocyte-like cells from human pluripotent stem cells are provided along with the related compositions. |
| FILED | Friday, February 19, 2021 |
| APPL NO | 17/796044 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0622 (20130101) Original (OR) Class C12N 2500/36 (20130101) C12N 2500/38 (20130101) C12N 2501/13 (20130101) C12N 2501/42 (20130101) C12N 2501/135 (20130101) C12N 2501/155 (20130101) C12N 2501/235 (20130101) C12N 2501/237 (20130101) C12N 2501/999 (20130101) C12N 2501/2306 (20130101) C12N 2506/02 (20130101) C12N 2506/45 (20130101) C12N 2533/52 (20130101) C12N 2533/54 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230056577 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| INVENTOR(S) | Feng Zhang (Cambridge, Massachusetts); Jonathan Strecker (Cambridge, Massachusetts); Alim Ladha (Cambridge, Massachusetts) |
| ABSTRACT | The present application provides systems, methods and compositions used for targeted gene modification, targeted insertion, perturbation of gene transcripts, nucleic acid editing. Novel nucleic acid targeting systems comprise components of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) systems and transposable elements. |
| FILED | Thursday, May 12, 2022 |
| APPL NO | 17/742503 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/1241 (20130101) Original (OR) Class C12N 15/11 (20130101) C12N 15/70 (20130101) C12N 15/85 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230056712 | OGEMBO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CITY OF HOPE (Duarte, California) |
| ASSIGNEE(S) | CITY OF HOPE (Duarte, California) |
| INVENTOR(S) | Javier Gordon OGEMBO (San Dimas, California); Lorraine Zvichapera MUTSVUNGUMA (Duarte, California) |
| ABSTRACT | Disclosed herein are antibodies or immunogenic fragments thereof that specifically bind to Epstein-Barr virus (EBV) glycoprotein 350 (gp350) or 220 or one or more immunogenic peptides. Also disclosed are immunogenic peptides comprising fragments of gp350 amino acid sequence, EBV antibody-small molecule conjugates and pharmaceutical compositions comprising the antibody or an immunogenic fragment thereof, one or more immunogenic peptides, or the EBV antibody-small molecule conjugate. The antibodies, immunogenic peptides, conjugates, and pharmaceutical compositions can be used to treat or prevent EBV infections and EBV-associated conditions and diseases. |
| FILED | Thursday, June 16, 2022 |
| APPL NO | 17/807363 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Peptides C07K 16/085 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230056729 | TURCHI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John J. TURCHI (Indianapolis, Indiana); Navnath GAVANDE (Indianapolis, Indiana) |
| ABSTRACT | This invention relates to RPA compounds or pharmaceutically acceptable salts thereof, and for the use of the compounds to treat cancer. |
| FILED | Thursday, December 10, 2020 |
| APPL NO | 17/782876 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 401/04 (20130101) Original (OR) Class C07D 401/14 (20130101) C07D 405/14 (20130101) C07D 413/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230056846 | Diaz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MEMORIAL SLOAN KETTERING CANCER CENTER (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Luis Alberto Diaz (New York, New York); Benoit Rousseau (New York, New York); Neil H. Segal (New York, New York) |
| ABSTRACT | In some embodiments the present invention provides methods useful for the treatment of MMR-proficient and/or microsatellite stable (MSS) cancers and also useful for enhancing the immunogenicity of MMR-proficient and/or microsatellite stable (MSS) cancer cells, enhancing the sensitivity of MMR-proficient and/or microsatellite stable (MSS) cancer cells to immune checkpoint blockade, inducing an MMR-deficient mutational signature in MMR-proficient and/or microsatellite stable (MSS) cancer cells, and/or increasing the frequency of both missense and InDel mutations in MMR-proficient and/or microsatellite stable (MSS) cancer cells. In some embodiments such methods involve administration of a combination of temozolomide and cisplatin, or a combination of temozolomide, cisplatin and an immune checkpoint inhibitor, to a subject in need thereof. |
| FILED | Wednesday, January 13, 2021 |
| APPL NO | 17/792557 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0053 (20130101) A61K 31/495 (20130101) Original (OR) Class A61K 33/243 (20190101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230056992 | Joo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Aggamin, LLC (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Woo S. Joo (Gaithersburg, Maryland); Karen M. Lee (Massapequa, New York); Adelene Y. Tan (New York, New York); Garrett D. Daniels (Mamaroneck, New York); Paul Kussie (New York, New York) |
| ABSTRACT | Disclosed are methods and apparatuses for treating a pregnancy related hypertensive disorder, such as pre-eclampsia and eclampsia, using ex vivo treatment with an anti-sFlt-1 antibody and an anti-sEng antibody bound to a solid support in order to reduce blood levels of sFlt-1 and sEng. The present disclosure relates to methods, systems, devices, and apparatuses for treating pregnancy-related hypertensive disorders such as pre-eclampsia and eclampsia. |
| FILED | Tuesday, December 08, 2020 |
| APPL NO | 17/783801 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/15 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/12 (20180101) Peptides C07K 16/2863 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230057076 | Jorgensen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William L. Jorgensen (Deep River, Connecticut); Vinay Trivedi-Parmar (Boston, Massachusetts) |
| ABSTRACT | In one aspect, the invention comprises compounds that bind and inhibit macrophage migration inhibitory factor. In another aspect, the invention provides methods of treating, ameliorating, and/or preventing inflammatory disease, neurological disorders and cancer using the compounds of the invention. |
| FILED | Monday, August 29, 2022 |
| APPL NO | 17/897961 |
| CURRENT CPC | Heterocyclic Compounds C07D 231/12 (20130101) C07D 231/16 (20130101) C07D 405/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230057085 | Ledbetter et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University Of Washington Through Its Center For Commercialization (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey A. Ledbetter (Seattle, Washington); Martha Hayden-Ledbetter (Seattle, Washington); Keith Elkon (Seattle, Washington); Xizhang Sun (Seattle, Washington) |
| ABSTRACT | Hybrid nuclease molecules and methods for treating an immune-related disease or disorder in a mammal, and a pharmaceutical composition for treating an immune-related disease in a mammal. |
| FILED | Wednesday, March 16, 2022 |
| APPL NO | 17/696364 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 16/18 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 9/96 (20130101) C12N 11/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230057150 | Ravetch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Rockefeller University (New York, New York) |
| ASSIGNEE(S) | The Rockefeller University (New York, New York) |
| INVENTOR(S) | Jeffrey V. Ravetch (New York, New York); Stylianos Bournazos (New York, New York) |
| ABSTRACT | The present invention relates to human IgG Fc domain variants with improved effector function and uses thereof. |
| FILED | Monday, March 21, 2022 |
| APPL NO | 17/699716 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Peptides C07K 16/00 (20130101) C07K 16/30 (20130101) Original (OR) Class C07K 16/462 (20130101) C07K 16/2887 (20130101) C07K 2317/24 (20130101) C07K 2319/33 (20130101) C07K 2319/035 (20130101) C07K 2319/35 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/85 (20130101) C12N 2015/8518 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/563 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230057231 | Xu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GE PRECISION HEALTHCARE LLC (WAUWATOSA, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Minfeng Xu (Ballston Lake, New York); Anbo Wu (Clifton Park, New York); Yihe Hua (Rexford, New York); Mark Ernest Vermilyea (Schenectady, New York); Thomas Kwok-Fah Foo (Clifton Park, New York); Paul St. Mark Shadforth Thompson (Stephentown, New York) |
| ABSTRACT | A system for minimizing MGI in a superconducting magnet system of an MRI system includes a thermal shield having bi-metal material. The thermal shield is configured to be disposed about a cold mass of the superconducting magnet system, wherein the bi-metal material is configured to minimize MGI. |
| FILED | Thursday, August 19, 2021 |
| APPL NO | 17/406678 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/3815 (20130101) G01R 33/3854 (20130101) G01R 33/3856 (20130101) Original (OR) Class Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 6/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230057304 | DENG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MEMORIAL SLOAN KETTERING CANCER CENTER (New York, New York) |
| ASSIGNEE(S) | MEMORIAL SLOAN KETTERING CANCER CENTER (New York, New York) |
| INVENTOR(S) | Liang DENG (New York, New York); Stewart SHUMAN (New York, New York); Jedd WOLCHOK (New York, New York); Taha MERGHOUB (New York, New York); Weiyi WANG (New York, New York); Peihong DAI (New York, New York); Ning YANG (New York, New York) |
| ABSTRACT | The present disclosure relates generally to the fields of oncology, virology and immunotherapy. It concerns poxviruses, specifically the highly attenuated modified vaccinia virus Ankara (MVA), and a recombinant modified vaccinia Ankara virus with deletion of vaccinia virulence factor E3 (MVAΔE3L), each further modified to express human Fms-like tyrosine kinase 3 ligand (Flt3L) or GM-CSF. The disclosure relates to use of the foregoing recombinant viruses as cancer immunotherapeutic agents. The foregoing recombinant poxviruses can also be used in combination with immune checkpoint blockade therapy. |
| FILED | Friday, February 25, 2022 |
| APPL NO | 17/681342 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 35/768 (20130101) A61K 39/0011 (20130101) A61K 39/3955 (20130101) Original (OR) Class A61K 2039/505 (20130101) A61K 2039/55522 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/521 (20130101) C07K 16/2818 (20130101) C07K 16/2827 (20130101) C07K 2317/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2710/24032 (20130101) C12N 2710/24121 (20130101) C12N 2710/24132 (20130101) C12N 2710/24143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230057355 | GOLDMAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF ROCHESTER (Rochester, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven A. GOLDMAN (Webster, New York); John MARIANI (Rochester, New York) |
| ABSTRACT | The present disclosure relates to methods of treating a human subject having a condition mediated by a deficiency in myelin and methods of increasing oligodendrocyte production from human glial progenitor cells. These methods involve selecting a human subject having a condition mediated by a deficiency in myelin or providing a population of human glial progenitor cells and administering to the subject or the population of human glial progenitor cells one or modulators of a cell signaling pathway selected from the group consisting of Notch signaling, cAMP signaling, CIP2A signaling, RXRA signaling, TCF7L2 signaling, and combinations thereof under conditions effective to treat the condition or increase oligodendrocyte production. |
| FILED | Tuesday, February 11, 2020 |
| APPL NO | 17/430768 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/30 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0622 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230057418 | Chivukula et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts); Whitehead Institute for Biomedical Research (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Raghu R. Chivukula (Somerville, Massachusetts); David M. Sabatini (Cambridge, Massachusetts) |
| ABSTRACT | Aspects of the present disclosure provide compositions comprising NEK10 for example, wild-type NEK10 or a hyper-active NEK10 mutant such as NEK10S684D, and methods of using such for treating a respiratory disorder such as bronchiectasis. |
| FILED | Tuesday, January 19, 2021 |
| APPL NO | 17/793142 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/45 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) Enzymes C12Y 207/11001 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/573 (20130101) G01N 33/6893 (20130101) G01N 2800/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230057428 | SCHNELL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Thomas Jefferson University (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthias Johannes SCHNELL (Harleysville, Pennsylvania); Christoph WIRBLICH (Wernau, Germany); Drishya KURUP (Philadelphia, Pennsylvania) |
| ABSTRACT | The present invention includes a vaccine comprising a SARS-CoV-2 spike protein (S) or portion thereof, and methods of use thereof. |
| FILED | Friday, August 05, 2022 |
| APPL NO | 17/817708 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/215 (20130101) Original (OR) Class A61K 2039/55572 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230057461 | Mili |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Stavroula Mili (Bethesda, Maryland) |
| ABSTRACT | Provided herein are antisense oligonucleotides (ASOs) specific for Rab13 and Net1, for example specific for a GA-rich region of the 3′-UTR. In some examples, the ASOs are modified. Methods of using these ASOs to reduce the migration of metastatic cancer cells are provided, for example as a use to treat metastatic cancer. |
| FILED | Tuesday, January 26, 2021 |
| APPL NO | 17/792507 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/11 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230057500 | Marty et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Marty (Tucson, Arizona); James Keener (Tucson, Arizona); Guozhi Zhang (Tucson, Arizona) |
| ABSTRACT | An automated system for lipid exchange-mass spectrometry, e.g., measuring affinity of a membrane protein for lipids. The automated systems herein can measure the specificity of membrane protein-lipid interactions, detect remodeling of the membrane environment, and determine optimal lipid composition for membrane proteins. |
| FILED | Thursday, February 04, 2021 |
| APPL NO | 17/796054 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/30 (20130101) G01N 30/7233 (20130101) Original (OR) Class G01N 33/58 (20130101) G01N 33/92 (20130101) G01N 35/0099 (20130101) G01N 2030/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230057542 | McDyer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John F. McDyer (Pittsburgh, Pennsylvania); Iulia-Dana Popescu (Pittsburgh, Pennsylvania); Akihiko Hoji (Carmel, Indiana) |
| ABSTRACT | This document relates to methods and materials involved in identifying and/or treating mammals having a CMV infection. For example, methods and materials for assessing a mammal having a CMV infection (e.g., a CMV seronegative human who received CMV seropositive donor transplant tissue) to determine if the mammal is likely to control the CMV infection or to determine if the mammal is unlikely to control the CMV infection are provided. Methods and materials for treating a mammal having a CMV infection (e.g., a CMV seronegative human who received CMV seropositive donor transplant tissue) that was either identified as being likely to control the CMV infection or identified as being unlikely to control the CMV infection also are provided. |
| FILED | Monday, July 06, 2020 |
| APPL NO | 17/623761 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/522 (20130101) A61K 31/662 (20130101) A61K 31/675 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230057592 | COTMAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carl W. COTMAN (Santa Ana, California); Larry E. OVERMAN (Corona del Mar, California); Shikha SNIGDHA (Long Beach, California) |
| ABSTRACT | Use of H3K9me3 modulation for enhancing cognitive function and treating anxiety related disorders is presented. A composition is administered to the subject comprising a therapeutically effective amount of a SUV39H1 inhibitor comprising analogs of ETP69. The therapeutically effective amount is effective in treating cognitive dysfunction in aging and age-related disorders. |
| FILED | Thursday, March 17, 2022 |
| APPL NO | 17/697893 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/27 (20130101) A61K 31/202 (20130101) A61K 31/445 (20130101) A61K 31/473 (20130101) A61K 31/522 (20130101) A61K 31/548 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) A61P 25/22 (20180101) A61P 25/28 (20180101) Heterocyclic Compounds C07D 513/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230057844 | Chesler et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Jackson Laboratory (Bar Harbor, Maine) |
| ASSIGNEE(S) | The Jackson Laboratory (Bar Harbor, Maine) |
| INVENTOR(S) | Elissa Chesler (Bar Harbor, Maine); Michael Saul (Bar Harbor, Maine) |
| ABSTRACT | Provided herein are methods and compositions for the treatment or prevention of certain disorders and conditions, for example, addiction using an agent to modulate 5-hydroxytryptamine 1D receptor (HTR1D) activity and/or expression. Also provided are methods for screening a candidate to determine if the candidate is suitable for the therapies disclosed herein. |
| FILED | Friday, December 18, 2020 |
| APPL NO | 17/787233 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/422 (20130101) A61K 31/4045 (20130101) A61K 31/4985 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230058146 | Wilson |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Temple University-Of The Commonwealth System of Higher Education (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robin Taylor Wilson (Philadelphia, Pennsylvania) |
| ABSTRACT | The present invention relates to compositions and methods relating to biomarkers (e.g., calcitriol (i.e., 1,25(OH)2D3) to 24,25-dihydroxyvitamin D3 (i.e., 24,25(OH)2D3) to calcifediol (i.e., 25(OH)D3) proportion ratio (C24CPR)) that can be used for detection and treatment assessment of vitamin D deficiency or vitamin D imbalance and/or diseases or disorders associated with vitamin D deficiency or vitamin D imbalance, such as cancer, in a subject in need thereof. The present invention also provides methods of diagnosing vitamin D deficiency or vitamin D imbalance and/or diseases or disorders associated with vitamin D deficiency or vitamin D imbalance and distinguishing between different types of diseases or disorders associated with vitamin D deficiency or vitamin D imbalance (e.g., cancer vs autoimmune disease or disorder). |
| FILED | Friday, August 05, 2022 |
| APPL NO | 17/817696 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/592 (20130101) A61K 31/593 (20130101) A61K 45/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/62 (20130101) G01N 33/82 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230058176 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David R. Liu (Cambridge, Massachusetts); Johnny Hao Hu (Cambridge, Massachusetts) |
| ABSTRACT | Some aspects of this disclosure provide compositions, methods, systems, and kits for controlling the activity and/or improving the specificity of RNA-programmable endonucleases, such as Cas9. For example, provided are guide RNAs (gRNAs) that are engineered to exist in an “on” or “off” state, which control the binding and hence cleavage activity of RNA-programmable endonucleases. Some aspects of this disclosure provide mRNA-sensing gRNAs that modulate the activity of RNA-programmable endonucleases based on the presence or absence of a target mRNA. Some aspects of this disclosure provide gRNAs that modulate the activity of an RNA-programmable endonuclease based on the presence or absence of an extended DNA (xDNA). |
| FILED | Monday, March 07, 2022 |
| APPL NO | 17/688416 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/96 (20130101) C12N 15/01 (20130101) C12N 15/63 (20130101) C12N 15/102 (20130101) C12N 15/113 (20130101) C12N 15/115 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2310/12 (20130101) C12N 2310/53 (20130101) C12N 2310/3519 (20130101) C12N 2320/53 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230058339 | Covey et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (, None) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Douglas Covey (St. Louis, Missouri); Charles Zorumski (St. Louis, Missouri); Yukitoshi Izumi (St. Louis, Missouri); Makoto Ishikawa (St. Louis, Missouri) |
| ABSTRACT | The present disclosure is directed to a composition for prevention or treatment of neurodegenerative conditions. The composition comprises a neurosteroid, a synthetic enantiomer of a neurosteroid, or a combination thereof. |
| FILED | Thursday, October 13, 2022 |
| APPL NO | 18/046244 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0048 (20130101) A61K 31/57 (20130101) Original (OR) Class A61K 47/40 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230058380 | Gittes et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | George Gittes (Pittsburgh, Pennsylvania); Xiangwei Xiao (Pittsburgh, Pennsylvania) |
| ABSTRACT | Methods are disclosed for polarizing macrophages to become M2 macrophages. Methods also are disclosed for treating type 1 diabetes in a subject. These methods include administering to the subject a vector comprising a macrophage specific promoter operably linked to a nucleic acid molecule encoding TNF-alpha-induced protein 8-like 2 (TIPE2) protein. In some embodiments, the vector is administered locally to a pancreas of the subject. In further embodiments, compositions are disclosed including a) a vector comprising a macrophage specific promoter operably linked to a nucleic acid molecule encoding TNF-alpha-induced protein 8-like 2 (TIPE2) protein; b) a buffer; and c) a contrast dye for endoscopic retrograde cholangiopancreatography. |
| FILED | Tuesday, December 29, 2020 |
| APPL NO | 17/789739 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/0058 (20130101) Original (OR) Class A61K 48/0075 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230058622 | LUBINSKY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (Albany, New York); UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (Knoxville, Tennessee); GEORGIA TECH RESEARCH CORPORATION (Atlanta, Georgia) |
| ASSIGNEE(S) | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (Albany, New York); UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (Knoxville, Tennessee); GEORGIA TECH RESEARCH CORPORATION (Atlanta, Georgia) |
| INVENTOR(S) | Anthony R. LUBINSKY (Port Jefferson, New York); Adrian HOWANSKY (Centereach, New York); Jacqueline JOHNSON (Tullahoma, Tennessee); Meredith Brooke BECKERT (Atlanta, Georgia); Charles BOND (Tullahoma, Tennessee) |
| ABSTRACT | Scintillating glass ceramics are disclosed. The scintillating glass ceramics may be used as an x-ray conversion layer (screen) for a flat panel imager (FPD) and as part of an imaging system. The FPD may have a single screen or a dual screen. The scintillating glass ceramics may be used for either a front screen or a back screen. The scintillating glass ceramics may be used for high energy x-ray applications including for energies of about 0.3 to about 20 MeV. A build-up layer may be attached to the scintillating glass ceramics for high energy applications. The scintillating glass ceramics may include a glass matrix hosting luminescent centers and light scattering centers. The materials used for the luminescent centers and light scattering centers may be the same or different. The scintillating glass ceramics may be coated onto a glass substrate. |
| FILED | Friday, January 22, 2021 |
| APPL NO | 17/790087 |
| CURRENT CPC | Measurement of Nuclear or X-radiation G01T 1/2002 (20130101) G01T 1/20188 (20200501) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230058726 | Mallery et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio); The Regents Of The University Of University (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Susan Regina Mallery (Columbus, Ohio); Steven Paul Schwendeman (Superior Township, Michigan) |
| ABSTRACT | The present disclosure is directed to formulations and methods for treatment of disease such as chemoprevention of cancer, for example oral squamous cell carcinoma (OSCC), and for methods of preparing the formulations. Further, the disclosure relates to local administration in slow release dosage forms for treatment of disease. The extended-release formulations are comprised of biodegradable polymeric implants (for example millicylinders and microspheres as well as in situ forming gels) and therapeutic agents selected from an anti-interleukin 6 agent, a synthetic vitamin A analogue and/or metabolite, and/or an estradiol metabolite for the local delivery of therapeutic agents to a site where a cancer has been previously excised or to prevent progression of a precancerous lesion. |
| FILED | Monday, October 31, 2022 |
| APPL NO | 17/977691 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/74 (20130101) A61K 31/167 (20130101) A61K 31/565 (20130101) A61K 39/3955 (20130101) Original (OR) Class A61K 45/00 (20130101) A61K 47/10 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2866 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230058740 | Lynch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Lynch (Durham, North Carolina); Romel Menacho Melgar (Durham, North Carolina) |
| ABSTRACT | Provide herein are engineered microbial strains having greatly improved expression of many challenging protein product. This system relies on controlled expression or dynamic reduction in activity of key housekeeping proteases. Dynamic control, implemented with CRISPR based gene silencing and or controlled protein degradation enables increased protein expression while minimizing the negative impact of complete deletions of these housekeeping enzymes. |
| FILED | Thursday, August 11, 2022 |
| APPL NO | 17/819100 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/70 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230058781 | Park et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ramona Optics Inc. (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jaehee Park (Durham, North Carolina); Mark Harfouche (Durham, North Carolina); Gregor Horstmeyer (Durham, North Carolina); Jed Doman (Durham, North Carolina); Paul Reamey (Durham, North Carolina) |
| ABSTRACT | A system and method for high resolution multi-fluorescence imaging with synchronized image acquisition amongst sensors can be used to simultaneously capture fluorescence signals from multiple fluorophores over extremely large fields of view. The system can include an array of micro-cameras, along with a particular arrangement of fluorescent filters that can be fixed in one location or moved to new locations. |
| FILED | Monday, October 31, 2022 |
| APPL NO | 17/978078 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 21/6458 (20130101) Original (OR) Class G01N 2021/6439 (20130101) Optical Elements, Systems, or Apparatus G02B 21/06 (20130101) G02B 21/16 (20130101) G02B 21/365 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230058961 | DEBNATH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | New York Blood Center, Inc. (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Asim Kumar DEBNATH (Fort Lee, New Jersey); Francesca CURRELI (West New York, New Jersey) |
| ABSTRACT | Substituted heterocyclic substituted pyrrole carboxamide compounds such as those represented by Formula I or Formula II are provided herein. Such compounds, or pharmaceutically acceptable salts thereof, can be used in the treatment of HIV infection and related conditions. |
| FILED | Thursday, November 19, 2020 |
| APPL NO | 17/777923 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/426 (20130101) A61K 31/4025 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230059009 | Roos et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martina Roos (Los Angeles, California); Michael E. Jung (Los Angeles, California); Hyo Jin Gim (Los Angeles, California) |
| ABSTRACT | The present disclosure relates to compounds of formula (I) and compositions comprising the same. The disclosure further relates to methods of treating cancers. |
| FILED | Monday, December 14, 2020 |
| APPL NO | 17/786764 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Heterocyclic Compounds C07D 471/04 (20130101) C07D 487/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230059132 | Li et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Quanzheng Li (Cambridge, Massachusetts); Kuang Gong (Malden, Massachusetts) |
| ABSTRACT | In accordance with one aspect of the disclosure, an image generation system is provided. The system includes at least one processor and at least one non-transitory, computer- readable memory accessible by the processor and having instructions that, when executed by the processor, cause the processor to receive a first patient image associated with a patient, receive a second patient image associated with the patient, train an untrained model based on the first patient image and the second patient image, provide the first patient image to the model, receive a third patient image from the model, and output the third patient image to at least one of a storage system or a display. |
| FILED | Monday, September 28, 2020 |
| APPL NO | 17/764459 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230059179 | HARASYMOWICZ et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri); Shriners Hospitals for Children (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | NATALIA HARASYMOWICZ (St. Louis, Missouri); FARSHID GUILAK (St. Louis, Missouri); CHIA-LUNG WU (St. Louis, Missouri); ROBERT NIMS (St. Louis, Missouri); RUHANG TANG (St. Louis, Missouri); ARIN OESTREICH (St. Louis, Missouri) |
| ABSTRACT | Among the various aspects of the present disclosure relates to methods and compositions useful in convert inflammatory dietary fatty acids (omega 6) to anti-inflammatory fatty acids (omega 3). Specifically, the present disclosure provides methods and compositions for increasing n-3 desaturase expression or activity in a subject. The disclosure provides various compositions for providing increased n-3 desaturase expression or activity including a variety of viral vector and engineered microorganisms The disclosure provides, in part, methods for reducing local and/or systemic inflammation, improving wound healing, preventing premature cellular enescence, treating or preventing a disease, disorder, or condition related to inflammation or obesity and treating or preventing arthritis. |
| FILED | Friday, January 29, 2021 |
| APPL NO | 17/796585 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 2267/0362 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 38/44 (20130101) A61K 48/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0004 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 2750/14143 (20130101) Enzymes C12Y 103/01 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230059186 | Sowers et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lawrence Sowers (Galveston, Texas); Mark Sowers (Galveston, Texas); Chia Wei Hsu (Galveston, Texas); Baljinnyam Tuvshintugs (Galveston, Texas) |
| ABSTRACT | Certain embodiments are directed to compositions and methods for solving problems associated with measuring T:G mispairs, U:G mispairs and other 5-substituted uracil mispairs. Certain embodiments are directed to a hybrid enzyme that is capable of finding and cutting the T of the T:G mispair or other mispaired uracil analogs creating a method for their measurement. In certain embodiments the hybrid enzyme is a fusion of a human thymine DNA glycosylase (TDG) activator segment and a catalytic domain of an archaeal thermophilic thymine glycosylase (tTDG). |
| FILED | Thursday, May 19, 2022 |
| APPL NO | 17/748871 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/2497 (20130101) C12N 15/63 (20130101) C12N 15/102 (20130101) Original (OR) Class Enzymes C12Y 302/02029 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230059301 | Hunt et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AGENUS INC. (Lexington, Massachusetts); The Board of Regents of the University of Oklahoma (Norman, Oklahoma) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Donald F. Hunt (Charlottesville, Virginia); Andrew Norris (Palmyra, Virginia); Ann Michelle English (Palmyra, Virginia); Jeffrey Shabanowitz (Charlottesville, Virginia); William H. Hildebrand (Edmond, Oklahoma); Oriana E. Hawkins (Tuscola, Texas) |
| ABSTRACT | The present invention describes novel tumor-specific phosphorylated peptides, nucleic acids encoding those peptides, and antibodies generated against said peptides. The genes, peptides, and antibodies described herein may be used as diagnostic indicators of the presence of breast cancer and/or used in therapeutics to treat breast cancer. |
| FILED | Friday, July 08, 2022 |
| APPL NO | 17/811546 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 39/0011 (20130101) Peptides C07K 7/06 (20130101) C07K 7/08 (20130101) Original (OR) Class C07K 14/4748 (20130101) C07K 16/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230059358 | Tillman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Bryan W. Tillman (Delaware, Ohio); Youngjae Chun (Wexford, Pennsylvania) |
| ABSTRACT | A multi-lumen implantable device configured to deliver a therapeutic agent to a selected portion of a blood vessel is disclosed. As one example, an implantable device includes a first lumen configured to flow blood from an upstream end to a downstream end of the device when implanted in a blood vessel; a second lumen fluidly separated from the first lumen and configured for introducing a therapeutic agent to a selected, first portion of a wall of the blood vessel, between the upstream end and the downstream end of the device; and at least one sealing member configured to block the therapeutic agent from entering a second portion of the wall of the blood vessel, between the upstream end and the downstream end of the device. |
| FILED | Friday, January 22, 2021 |
| APPL NO | 17/797070 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/958 (20130101) A61F 2250/0067 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/3659 (20140204) Original (OR) Class A61M 25/0032 (20130101) A61M 25/1011 (20130101) A61M 2025/0031 (20130101) A61M 2025/0037 (20130101) A61M 2025/1095 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230059548 | SGOURAKIS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nikolaos G. SGOURAKIS (Philadelphia, Pennsylvania); Gioro MOROZOV (Santa Cruz, California) |
| ABSTRACT | Provided herein are novels systems and methods for the identification of peptides that bind to MHC-I molecules using peptide receptive MHC-I complexes. |
| FILED | Monday, January 04, 2021 |
| APPL NO | 17/790711 |
| CURRENT CPC | Peptides C07K 1/22 (20130101) C07K 14/70539 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1037 (20130101) Original (OR) Class C12N 15/1055 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6848 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230059552 | Maghodia et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Glycobac, LLC (Laramie, Wyoming) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ajay Maghodia (Laramie, Wyoming); Christoph Geisler (Laramie, Wyoming); Donald Jarvis (Laramie, Wyoming) |
| ABSTRACT | The current teachings are directed to novel virus free cells lines derived from virus-contaminated staring material, such as an organism or a cell line. Methods for obtaining virus free cell lines obtained from virus-contaminated starting material are also provided. Exemplary virus free cell lines include: novel cell lines derived from a Spodoptera frugiperda cell line contaminated with Sf-rhabdovirus, wherein the novel cell lines lack Sf-rhabdovirus; and novel cell lines derived from a Trichoplusia ni cell line contaminated with an alphanodavirus, wherein the novel cell line lacks an alphanodavirus. |
| FILED | Monday, September 12, 2022 |
| APPL NO | 17/931200 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0601 (20130101) Original (OR) Class C12N 7/00 (20130101) C12N 15/00 (20130101) C12N 2500/40 (20130101) C12N 2710/14151 (20130101) C12N 2760/20011 (20130101) C12N 2770/30011 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230059717 | Madabhushi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anant Madabhushi (Shaker Heights, Ohio); Andrew Janowczyk (East Meadow, New York) |
| ABSTRACT | The present disclosure relates to a non-transitory computer-readable medium storing computer-executable instructions that, when executed, cause a processor to perform operations. The operations include extracting one or more image characterization metrics from respective ones of a plurality of digitized images within an imaging data set. The plurality of digitized images have batch effects. The operations further include identifying a plurality of batch effect groups of the digitized images using the one or more image characterization metrics, and dividing the plurality of batch effect groups between a training set and/or a validation set. The training set and/or the validation set include some of the plurality of digitized images associated with respective ones of the plurality of batch effect groups. |
| FILED | Friday, August 19, 2022 |
| APPL NO | 17/891321 |
| CURRENT CPC | Image or Video Recognition or Understanding G06V 10/48 (20220101) G06V 10/776 (20220101) G06V 10/7635 (20220101) G06V 20/695 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20230053475 | PAGE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE MITRE CORPORATION (McLean, Virginia) |
| ASSIGNEE(S) | THE MITRE CORPORATION (McLean, Virginia) |
| INVENTOR(S) | Mark A. PAGE (Littleton, Massachusetts); Steen A. PARL (Arlington, Massachusetts); Scott ZHAO (Somerville, Massachusetts) |
| ABSTRACT | A communications system and methods for covert communications are provided. A first transmitter that transmits an information carrying signal to a target receiver, a second transmitter and a third transmitter transmit jamming signals to the target receiver, such that the information carrying signals and the jamming signals are interleaved when received by the target receiver The information carrying signals and the jamming signals can be at least partially overlapping by an eavesdropper. |
| FILED | Friday, February 25, 2022 |
| APPL NO | 17/680855 |
| CURRENT CPC | Secret Communication; Jamming of Communication H04K 3/65 (20130101) H04K 3/825 (20130101) Original (OR) Class H04K 2203/32 (20130101) H04K 2203/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230053484 | Russo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Analog Photonics LLC (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter Nicholas Russo (Somerville, Massachusetts); Ehsan Shah Hosseini (Milton, Massachusetts) |
| ABSTRACT | At least one beam of an optical wave is transmitted along a transmission angle toward a target location from a send aperture of a transmitter. A collected optical wave is received at receive apertures of two or more receivers. Each receiver comprises: a receive aperture arranged in proximity to at least one of the send aperture or a receive aperture of a different receiver, an optical phased array within the receive aperture, which receives at least a portion of a collected optical wave arriving at the receive aperture along a respective collection angle, and a detector that provides a signal based on the received portion of the collected optical wave. An estimated distance associated with the collected optical wave is determined based on a combination that includes a respective component corresponding to each of two or more of the signals provided from the detectors of the two or more receivers. |
| FILED | Thursday, November 03, 2022 |
| APPL NO | 17/979931 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/282 (20130101) G01S 17/42 (20130101) Original (OR) Class Antennas, i.e Radio Aerials H01Q 3/2676 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230053634 | CLARK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington); ABACUS BIOSCIENCE, INC. (Sammamish, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edward A. CLARK (Seattle, Washington); Che-Leung LAW (Seattle, Washington); Deborah FULLER (Seattle, Washington); Michael GALE (Seattle, Washington) |
| ABSTRACT | Compositions including a CD180 binding ligand and a linked Hepatitis B antigen and their use are disclosed. The Hepatitis B antigen includes Hepatitis B virus pre-S1 and/or pre-S2 region of the HBV envelope protein (HBVpre S1/S2Ag), L-HBsAg, MHBsAg, S-HBsAg, or antigenic fragments or mutants thereof. |
| FILED | Friday, July 01, 2022 |
| APPL NO | 17/810480 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/292 (20130101) Original (OR) Class A61K 2039/6056 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/20 (20180101) Peptides C07K 16/2878 (20130101) C07K 16/2896 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230053851 | Zhou et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Weidong Zhou (Southlake, Texas); Mingsen Pan (Arlington, Texas) |
| ABSTRACT | A high speed spatial light modulators are described. In one non-limiting example, an optical phased array structure comprises a vertical cavity surface-emitting laser (VCSEL) that provides a light beam and a phase delay unit that includes a bi-layer photonic crystal slab. The bi-layer photonic crystal slab (PCS) is attached to the VCSEL and comprises two silicon PCS layers separated by a dielectric layer. The optical phased array structure is configured to control a direction of the light beam by a voltage applied to the phase delay unit. By incorporating a dispersive layer (e.g. graphene), the absorption of the structure can be modulated and accordingly the reflection of the surface can be modulated as well. |
| FILED | Wednesday, July 27, 2022 |
| APPL NO | 17/815339 |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/11 (20210101) H01S 5/04253 (20190801) H01S 5/04254 (20190801) H01S 5/04256 (20190801) H01S 5/06243 (20130101) H01S 5/06246 (20130101) H01S 5/18302 (20130101) Original (OR) Class H01S 5/18375 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230053902 | Love et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); Rensselaer Polytechnic Institute (Troy, New York) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); Rensselaer Polytechnic Institute (Troy, New York) |
| INVENTOR(S) | J. Christopher Love (Somerville, Massachusetts); Kerry R. Love (Somerville, Massachusetts); Laura Crowell (Cambridge, Massachusetts); Alan Stockdale (Providence, Rhode Island); Richard Dean Braatz (Arlington, Massachusetts); Amos Enshen Lu (Cambridge, Massachusetts); Steven Cramer (Troy, New York); Steven Timmick (Troy, New York); Nicholas Vecchiarello (Troy, New York); Chaz Goodwine (Troy, New York); Craig A. Mascarenhas (Brookline, Massachusetts) |
| ABSTRACT | Aspects of the present disclosure relate to systems and methods for manufacturing biologically-produced pharmaceutical products. Some of the systems described herein comprise an upstream component comprising a bioreactor and at least one filter (e.g., a filter probe) integrated with a downstream component comprising a purification module comprising at least a first partitioning unit and a second partitioning unit. In some embodiments; these integrated biomanufacturing systems may be operated under continuous or conditions and may be capable of efficiently producing pure, high-quality pharmaceutical products. |
| FILED | Wednesday, March 09, 2022 |
| APPL NO | 17/690876 |
| CURRENT CPC | Peptides C07K 1/20 (20130101) C07K 16/00 (20130101) Apparatus for Enzymology or Microbiology; C12M 29/10 (20130101) Original (OR) Class C12M 41/44 (20130101) C12M 47/10 (20130101) C12M 47/12 (20130101) Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 20/10 (20190201) G16C 20/20 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230054018 | Gamache |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Raymond Mark Gamache (Salinas, California) |
| ABSTRACT | A water submersion detection system that may include a buoyant device having a conductive surface, and a housing enclosing the buoyant device and having conductive elements. The conductive elements may include a first set of one or more nonadjacent conductive elements that are electrically connected, and a second set of one or more nonadjacent conductive elements that are electrically connected. The system may include a submersion alert device that activates responsive to the buoyant device contacting the housing. |
| FILED | Thursday, November 11, 2021 |
| APPL NO | 17/524120 |
| CURRENT CPC | Measuring Volume, Volume Flow, Mass Flow or Liquid Level; Metering by Volume G01F 23/76 (20130101) G01F 23/683 (20130101) Original (OR) Class Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 21/088 (20130101) G08B 21/182 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230054064 | Lontz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HDT EXPEDITIONARY SYSTEMS, INC. (Solon, Ohio) |
| ASSIGNEE(S) | HDT EXPEDITIONARY SYSTEMS, INC. (Solon, Ohio) |
| INVENTOR(S) | Travis Lontz (Fredericksburg, Virginia); Charles Deighton (Milford, Ohio); Wade Milek (Mason, Ohio) |
| ABSTRACT | An expandable wall shelter includes a body and a movable wall section connected to the body and movable between a retracted position and an extended position along a linear path. At least one linkage assembly is operably connected between the body and the movable wall section for operably and movably supporting the movable wall section relative to the body for movement of the movable wall section to and between its retracted and extended positions. The at least one linkage assembly includes: (i) an inner link including opposite inner and outer ends; and (ii) an outer link including opposite inner and outer ends, wherein: the inner end of the inner link is pivotally connected to the body; the said outer end of the outer link is pivotally connected to the movable wall section; and, the outer end of the inner link is pivotally connected to the inner end of the outer link. A linkage assembly for such a movable wall section is also provided. |
| FILED | Thursday, July 14, 2022 |
| APPL NO | 17/864602 |
| CURRENT CPC | Vehicles Adapted for Load Transportation or to Transport, to Carry, or to Comprise Special Loads or Objects B60P 3/34 (20130101) Original (OR) Class B60P 3/36 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230054128 | LAL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amit LAL (Ithaca, New York); Shubham JADHAV (Ithaca, New York); Ved GUND (Ithaca, New York); Benyamin DAVAJI (Ithaca, New York); Grace XING (Ithaca, New York); Debdeep JENA (Ithaca, New York) |
| ABSTRACT | Disclosed are ferroelectric devices including devices for performing a multiplication of analog input signals and resonators. In one aspect, a ferroelectric nanoelectromechanical device includes a first structural beam, a first input electrode disposed on a first top portion of the first structural beam, and an output electrode. The apparatus further includes a first ferroelectric film disposed on a second top portion of the first input electrode, and a first resistive layer disposed on a third top portion of the first ferroelectric film, wherein a first electrode is positioned at a first end of the first resistive layer and a second electrode is positioned at a second end of the first resistive layer. |
| FILED | Tuesday, August 23, 2022 |
| APPL NO | 17/821789 |
| CURRENT CPC | Static Stores G11C 23/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230054335 | Macias et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Platelet Biogenesis, Inc. (Watertown, Massachusetts) |
| ASSIGNEE(S) | Platelet Biogenesis, Inc. (Watertown, Massachusetts) |
| INVENTOR(S) | Jorge Luis Valdez Macias (Watertown, Massachusetts); Marcus Lehmann (Watertown, Massachusetts); Jonathan N. Thon (Watertown, Massachusetts); Douglas G. Savin (Watertown, Massachusetts) |
| ABSTRACT | There is provided a method of making a fluidic system that comprises assembling a fluidic system comprising a first plate, a second plate and a membrane disposed between the first plate and the second plate; applying laser energy to the fluidic system to cause the first plate, the second plate and the membrane to melt at bonding areas; and allowing the bonding areas to cool down such that the first plate, the second plate and the membrane are bonded together. |
| FILED | Friday, August 19, 2022 |
| APPL NO | 17/891306 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502707 (20130101) Original (OR) Class B01L 2300/0681 (20130101) B01L 2300/0816 (20130101) B01L 2300/0864 (20130101) B01L 2300/0867 (20130101) B01L 2300/0887 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 65/1635 (20130101) B29C 65/1696 (20130101) B29C 66/244 (20130101) B29C 66/1142 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230054359 | BOOTHBY |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF WYOMING (Laramie, Wyoming) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas BOOTHBY (Laramie, Wyoming) |
| ABSTRACT | Embodiments of the present disclosure generally relate to methods and compositions for stabilizing biological material using intrinsically disordered proteins. In an embodiment, a composition is provided, the composition including a first component comprising at least one intrinsically disordered protein; and a second component comprising at least one biological material of interest, at least one biologically-derived material of interest, or both, the second component being free of the at least one intrinsically disordered protein. The methods and compositions include at least one intrinsically disordered protein that can be modified to prevent, or at least mitigate, polymerization thereof and the formation of gel-like matrices, thereby, e.g., improving the ability of the intrinsically disordered proteins to protect and stabilize sensitive biological materials. |
| FILED | Friday, January 28, 2022 |
| APPL NO | 17/586930 |
| CURRENT CPC | Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 3/3526 (20130101) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 47/42 (20130101) Peptides C07K 14/43504 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/96 (20130101) C12N 9/1025 (20130101) Enzymes C12Y 203/03001 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/20 (20190201) G16B 15/30 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230054382 | Burback et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Jessica Catherine Bright (Dublin, Ohio); Battelle Memorial Institute (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian L. Burback (Hilliard, Ohio); Jessica Catherine Bright (Dublin, Ohio); Jerry D. Johnson (Dublin, Ohio) |
| ABSTRACT | Disclosed herein are methods of reducing muscle contraction in a diaphragm or peripheral muscle(s) of a patient sufficient to permit a surgical procedure. The methods may comprise the step of administering an oxime or pharmaceutically acceptable salt thereof to a subject in need thereof in an amount sufficient to achieve said reduced muscle contraction/neuromuscular blockade. Kits and articles of manufacture comprising a container having a label and a composition are also disclosed. |
| FILED | Tuesday, June 21, 2022 |
| APPL NO | 17/845905 |
| CURRENT CPC | Containers Specially Adapted for Medical or Pharmaceutical Purposes; Devices or Methods Specially Adapted for Bringing Pharmaceutical Products into Particular Physical or Administering Forms; Devices for Administering Food or Medicines Orally; Baby Comforters; Devices for Receiving Spittle A61J 1/14 (20130101) A61J 2205/30 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/15 (20130101) A61K 31/444 (20130101) Original (OR) Class A61K 31/4425 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/02 (20180101) A61P 41/00 (20180101) A61P 43/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230054578 | Yurke |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Boise State University (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bernard Yurke (Boise, Idaho) |
| ABSTRACT | The present disclosure is directed to an optically active medium comprising dye aggregates and optionally a nucleotide oligomer or other nucleotide-based architecture, which may be used in in optical devices, in particular nonreciprocal devices (i.e., devices in which energy flows in one direction only), that can respond to differences in the polarization of light. An analysis is presented of the energy levels and the strengths of the optical transitions (changes in energy states) for a three-chromophore (dye) aggregate in which the chromophores are coupled with a J-like (i.e., end-to-end) stacking. Specific devices and methods of use are also disclosed herein. |
| FILED | Friday, July 23, 2021 |
| APPL NO | 17/443285 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/3503 (20210101) Original (OR) Class G02F 1/3515 (20130101) G02F 1/3612 (20130101) G02F 1/3615 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230054721 | Sweeney |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Robert Sweeney (Billerica, Massachusetts) |
| ABSTRACT | Radar, lidar, and other active 3D imaging techniques require large, heavy sensors that consume lots of power. Passive 3D imaging techniques based on feature matching are computationally expensive and limited by the quality of the feature matching. Fortunately, there is a robust, computationally inexpensive way to generate 3D images from full-motion video acquired from a platform that moves relative to the scene. The full-motion video frames are registered to each other and mapped to the scene coordinates using data about the trajectory of the platform with respect to the scene. The time derivative of the registered frames equals the product of the height map of the scene, the projected angular velocity of the platform, and the spatial gradient of the registered frames. This relationship can be solved in (near) real time to produce the height map of the scene from the full-motion video and the trajectory. |
| FILED | Friday, August 28, 2020 |
| APPL NO | 17/005410 |
| CURRENT CPC | Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 47/00 (20130101) Image Data Processing or Generation, in General G06T 7/579 (20170101) Original (OR) Class G06T 7/593 (20170101) G06T 2207/10021 (20130101) G06T 2207/10032 (20130101) G06T 2207/10048 (20130101) G06T 2207/30241 (20130101) Pictorial Communication, e.g Television H04N 13/106 (20180501) H04N 13/207 (20180501) H04N 2013/0085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230054895 | TAKEDA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts); TRUSTEES OF TUFTS COLLEGE (Boston, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts); TRUSTEES OF TUFTS COLLEGE (Boston, Massachusetts) |
| INVENTOR(S) | Takako TAKEDA (Cambridge, Massachusetts); Megan Sperry (Cambridge, Massachusetts); Erica Gardner (Cambridge, Massachusetts); Michael Levin (Cambridge, Massachusetts); Charles Reilly (Cambridge, Massachusetts); Richard Novak (Jamaica Plain, Massachusetts); Donald E. Ingber (Boston, Massachusetts) |
| ABSTRACT | Provided herein are methods for promoting biostasis or preservation of a cell, tissue or organ during cancer treatment or for transplantation comprising contacting the cell, tissue or organ with an agonist of the δ-opioid receptor, SNC-80, an or Donepezil. Further provided herein is a method of treating a hematological neoplastic disease. |
| FILED | Friday, January 08, 2021 |
| APPL NO | 17/791775 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0226 (20130101) Original (OR) Class Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230054994 | Martin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Brett D. Martin (Washington, District of Columbia); Ian D. Giles (Alexandria, Virginia); Jawad Naciri (Arlington, Virginia); Paul T. Charles (Bowie, Maryland); Scott A. Trammell (Springfield, Virginia); Jeffrey R. Deschamps (Laurel, Maryland); Jeffrey C. Depriest (Alexandria, Virginia) |
| ABSTRACT | This disclosure concerns electrically conducting poly(pyrazoles). The concept of oligomerizing and polymerizing substituted aminopyrazole derivatives combined with a monomer activation procedure involving base-mediated conversion of the protonated pyrazole ring nitrogen to amine salt was developed. This disclosure concerns the specific chemistries needed for the synthesis of a pyrazole monomer used in the polymer synthesis. The procedure used for blending the novel polypyrazoles with other compounds needed for construction of solar cells for testing was developed. This disclosure concerns the concept of using these types of heteroatom-rich, electron-deficient oligomers or polymers as n-dopable or p-dopable electron acceptors in photovoltaic cells. This disclosure concerns synthesizing the starting monomer compounds and polypyrazoles. |
| FILED | Tuesday, October 25, 2022 |
| APPL NO | 17/972968 |
| CURRENT CPC | Heterocyclic Compounds C07D 231/38 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 73/0616 (20130101) Compositions of Macromolecular Compounds C08L 79/04 (20130101) Original (OR) Class C08L 2203/204 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/127 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230055137 | JOHNSON, JR. et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alan T. JOHNSON, JR. (Philadelphia, Pennsylvania); Jinglei PING (Gaithersburg, Maryland); Ramya VISHNUBHOTLA (Philadelphia, Pennsylvania) |
| ABSTRACT | Provided are devices and methods for detecting a target molecule, based on using a graphene electrode. The devices exhibit high sensitivity to target molecules such as DNA that may be present at comparatively low concentrations. |
| FILED | Thursday, September 22, 2022 |
| APPL NO | 17/934540 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 15/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/327 (20130101) Original (OR) Class G01N 27/4146 (20130101) G01N 33/5438 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230055262 | Knotek-Smith et al. |
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| FUNDED BY |
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| APPLICANT(S) | United States of America - US Army (Alexandria, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Heather Marie Knotek-Smith (Vicksburg, Mississippi); David Lyman Smith (Vicksburg, Mississippi) |
| ABSTRACT | An iron containing bioreactor for treating explosive compounds and other organics in contaminated surface water is disclosed. The bioreactor can be located either on-ground or in-ground at a location across which contaminated surface water flows. In one configuration the reactor is made up of (i) indigenous microbes, (ii) acetate, (iii) a low density iron-containing bed, and contains anaerobic zones in at least one portion of the flowpath. The reactor reduces the concentration of explosive compounds to below 10 ppb and also maintains this explosive compound reduction level for a period of at least one year without replenishing the microbes or iron. |
| FILED | Saturday, September 30, 2017 |
| APPL NO | 15/721886 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/705 (20130101) C02F 3/284 (20130101) C02F 3/346 (20130101) C02F 3/2806 (20130101) Original (OR) Class C02F 3/2813 (20130101) C02F 2003/001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230055396 | Allaei et al. |
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| FUNDED BY |
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| APPLICANT(S) | SWG RED LLC (Jupiter, Florida) |
| ASSIGNEE(S) | SWG RED LLC (Jupiter, Florida) |
| INVENTOR(S) | Daryoush Allaei (Minneapolis, Minnesota); Benjamin Reydel (Mahwah, New Jersey); James Rall (Mahwah, New Jersey) |
| ABSTRACT | Energy dissipation pads are described herein. In one aspect, a system can include an airdrop load; and at least one energy-dissipation assembly having a grid formed from a plurality of boards each including a plurality of slots sufficient to accommodate a thickness of others of the plurality of boards and form a plurality of joints; where at least one of the at least one energy-dissipation assemblies is positioned below or within the airdrop load such that the grid of the energy-dissipation assembly is at least partially perpendicular to an anticipated impact vector. |
| FILED | Wednesday, August 17, 2022 |
| APPL NO | 17/820334 |
| CURRENT CPC | Springs; Shock-absorbers; Means for Damping Vibration F16F 3/0873 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230055779 | Pruessner et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Government of the United States, as represented by the Secretary of the Navy (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marcel W. Pruessner (Chevy Chase, Maryland); Dmitry A. Kozak (Berwyn Heights, Maryland); Todd H. Stievater (Arlington, Virginia); Brian J. Roxworthy (Chevy Chase, Maryland) |
| ABSTRACT | Methods and apparatuses for mode conversion. An apparatus that includes a substrate, a first waveguide, a second waveguide, a micro-electro-mechanical systems (MEMS) perturber, and a controller is provided. The first waveguide is formed on the substrate includes: (i) an input section, (ii) a bend section, and (iii) an output section. The second waveguide is also formed on the substrate and is disposed adjacent to a portion of the input section of the first waveguide. A portion of the second waveguide is separated from the input section of the first waveguide by a coupling gap. The perturber is disposed above the first waveguide and configured to move between a first position that is distal from a surface of the input section of the first waveguide and a second position that is closer to the surface of the input section of the first waveguide than the second position. The controller is configured to control a movement of the perturber between the first position and the second position. When the perturber is in the first position, a mode effective refractive index of the first waveguide is lower than the mode effective refractive index of the first waveguide when the perturber is in the second position. |
| FILED | Friday, August 20, 2021 |
| APPL NO | 17/408051 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230055859 | Prentice |
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| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patlerson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Prentice (Springboro, Ohio) |
| ABSTRACT | A decoder for the MIL-STD-1553B bus which operates at a slower clock rate than the 40 MHz industry standard clock rate. This embodiment uses a 10 MHz clock rate. Because the clock rate is slower than the 40 MHz clock rate, the invention will inherently use less power. Additional features of this invention include: flexible resolution timestamp input, error checking and reporting throughout the decode process and 32 bit buffered parallel output of the bus controller and remote terminal communication. In another embodiment the decoder has a plurality of n ancillary clocks which provide partial state timestamps, which are summable to create a system timestamp. |
| FILED | Friday, August 19, 2022 |
| APPL NO | 17/820948 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 12/4013 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230055916 | Timler et al. |
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| FUNDED BY |
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| APPLICANT(S) | Science Applications International Corporation (Reston, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John P. Timler (River Ridge, Louisiana); Xingcun C. Tong (Bolingbrook, Illinois) |
| ABSTRACT | Self-sintering thermal interface material is prepared from a polymer matrix and a filler. The polymer matrix may be a water or hydrogen peroxide or other water-contained solvent solution such as ammonia or alcohol containing a water soluble resin and fumed silica or an alcohol or other solvent solution containing at least one water insoluble resin and fumed silica. The filler contains i) gallium alkali metal or gallium metal, ii) one or more micro/nano-sized metallic fillers, and iii) dielectric fillers. |
| FILED | Tuesday, May 24, 2022 |
| APPL NO | 17/752041 |
| CURRENT CPC | Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/013 (20180101) Original (OR) Class C08K 3/105 (20180101) C08K 2201/011 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230055980 | Ding et al. |
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| FUNDED BY |
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| APPLICANT(S) | Kaize Ding (Tempe, Arizona); Huan Liu (Tempe, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on Behalf of Arizona State University (Tempe, Arizona) |
| INVENTOR(S) | Kaize Ding (Tempe, Arizona); Huan Liu (Tempe, Arizona) |
| ABSTRACT | Various embodiments of systems and methods for inductive anomaly detection on attributed networks using a graph neural layer to learn anomaly-aware node representations and further employ generative adversarial learning to detect anomalies among new data are disclosed herein. |
| FILED | Wednesday, May 11, 2022 |
| APPL NO | 17/742236 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/088 (20130101) G06N 3/0454 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230056283 | STEWART |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF UTAH RESEARCH FOUNDATION (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Russell J. STEWART (Salt Lake City, Utah) |
| ABSTRACT | Described herein are fluid complex coacervates that produce solid adhesives in situ. Oppositely charged polyelectrolytes were designed to form fluid adhesive complex coacervates at ionic strengths higher than the ionic strength of the application site, but an insoluble adhesive solid or gel at the application site. When the fluid, high ionic strength adhesive complex coacervates are introduced into the lower ionic strength application site, the fluid complex coacervate is converted to a an adhesive solid or gel as the salt concentration in the complex coacervate equilibrates to the application site salt concentration. In one embodiment, the fluid complex coacervates are designed to solidify in situ at physiological ionic strength and have numerous medical applications. In other aspects, the fluid complex coacervates can be used in aqueous environment for non-medical applications. |
| FILED | Monday, September 12, 2022 |
| APPL NO | 17/931242 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/0043 (20130101) A61K 49/0054 (20130101) A61K 49/0073 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 24/02 (20130101) A61L 24/10 (20130101) A61L 24/0015 (20130101) A61L 24/0031 (20130101) A61L 24/0042 (20130101) A61L 24/043 (20130101) A61L 24/046 (20130101) Original (OR) Class A61L 24/104 (20130101) A61L 2300/44 (20130101) A61L 2300/416 (20130101) A61L 2430/02 (20130101) A61L 2430/36 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/1668 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230056534 | Popa et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bogdan Ioan Popa (Ann Arbor, Michigan); Bogdan Epureanu (Ann Arbor, Michigan); Hyung-Suk Kwon (Ann Arbor, Michigan) |
| ABSTRACT | An acoustic lens to steer an acoustic beam includes a first structure, a second structure spaced from the first structure, an array of projections disposed between the first and second structures, each projection of the array of projections extending from the first structure toward the second structure to define a respective gap between the projection and the second structure, and an actuator configured to move the first structure, the second structure, or the array of projections for collective adjustment of the respective gaps of the array of projections. Each projection is configured to define one or more respective unit cells, each unit cell having a sub-wavelength size relative to the acoustic beam to establish an effective refractive index profile for the acoustic beam between the first and second structures. The actuator is configured such that the collective adjustment of the respective gaps varies across the array of projections to spatially modify the effective refractive index profile to steer the acoustic beam. |
| FILED | Friday, May 13, 2022 |
| APPL NO | 17/743878 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/00 (20130101) Methods or Apparatus for Generating or Transmitting Mechanical Vibrations of Infrasonic, Sonic, or Ultrasonic Frequency, for Performing Mechanical Work in General B06B 1/067 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/221 (20130101) Sound-producing Devices; Methods or Devices for Protecting Against, or for Damping, Noise or Other Acoustic Waves in General; Acoustics Not Otherwise Provided for G10K 11/30 (20130101) Original (OR) Class Antennas, i.e Radio Aerials H01Q 15/0086 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230056646 | Jung et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America as Represented by The Secretary of The Army (Alexandria, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carina M Jung (Vicksburg, Mississippi); Karl J Indest (Ridgeland, Mississippi); Matthew R Carr (Madison, Mississippi); Nathan E Harms (Edwards, Mississippi) |
| ABSTRACT | Recombinant MlrA and MlrB proteins having enzymatic activity against microcystin (MC) degrade and reduce the toxicity of MC. Compositions of the proteins can be used in the remediation of MC toxin generated from harmful cyanobacterial and algal blooms. Recombinant proteins, nucleic acids, host cells, and methods of producing the MlrA and MlrB are disclosed. |
| FILED | Tuesday, August 17, 2021 |
| APPL NO | 17/405012 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 3/342 (20130101) C02F 2101/38 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/48 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230056817 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brad Chun-Ting Liu (San Diego, California); Sergio A. Montoya (Chula Vista, California); Saurabh Sharma (San Diego, California); Carlos Torres, JR. (San Diego, California); Marico C. de Andrade (San Diego, California); Michael C. O'Brien (San Diego, California) |
| ABSTRACT | A cryogenic system cools and operates cryogenic electronics. The cryogenic system includes a cryogenic stage or multiple cryogenic stages for cooling the cryogenic electronics to an operational cryogenic temperature. The cryogenic stage or stages transfer heat from the cryogenic electronics to an ambient environment. An optical fiber or multiple optical fibers deliver an operational power from the ambient environment to the cryogenic electronics and transfer communication data between the cryogenic electronics and the ambient environment. Preferably, the only connection delivering any power from the ambient environment to the cryogenic electronics or transferring any data from the cryogenic electronics to the ambient environment is the optical fiber or fibers, such that the cryogenic system does not include any electrically conductive wires spanning between the ambient environment and the cryogenic electronics. |
| FILED | Friday, August 20, 2021 |
| APPL NO | 17/408232 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 39/16 (20130101) Original (OR) Class Transmission H04B 10/40 (20130101) H04B 10/808 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230056852 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David R. Liu (Cambridge, Massachusetts); John Paul Guilinger (Cambridge, Massachusetts); David B. Thompson (Cambridge, Massachusetts) |
| ABSTRACT | Some aspects of this disclosure provide compositions, methods, and kits for improving the specificity of RNA-programmable endonucleases, such as Cas9. Also provided are variants of Cas9, e.g., Cas9 dimers and fusion proteins, engineered to have improved specificity for cleaving nucleic acid targets. Also provided are compositions, methods, and kits for site-specific nucleic acid modification using Cas9 fusion proteins (e.g., nuclease-inactivated Cas9 fused to a nuclease catalytic domain or a recombinase catalytic domain). Such Cas9 variants are useful in clinical and research settings involving site-specific modification of DNA, for example, genomic modifications. |
| FILED | Friday, September 30, 2022 |
| APPL NO | 17/937203 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/465 (20130101) Peptides C07K 14/315 (20130101) C07K 2319/80 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 9/1241 (20130101) C12N 15/01 (20130101) C12N 15/907 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230056910 | Rhee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RAYTHEON COMPANY (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jehyuk Rhee (Newbury Park, California); Henry Lee (Goleta, California); Matthew C. Thomas (Carpinteria, California) |
| ABSTRACT | A trigger sense circuit includes a pseudo-differential comparator circuit in signal communication with a pixel array. The pseudo-differential comparator circuit includes a first input in signal communication with a reference pixel group included in the pixel array to receive a pixel reference voltage, and a second input in signal communication with a target pixel group included in the pixel array to receive a pixel target voltage. The pseudo-differential comparator circuit is configured to selectively operate in a calibration mode to remove false trigger events and a comparison mode to detect at least one overheated pixel included in the target pixel group. |
| FILED | Thursday, August 19, 2021 |
| APPL NO | 17/406432 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 5/24 (20130101) Original (OR) Class G01J 2005/0077 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230056933 | Holmes |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crance, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Harrison E. Holmes (Bloomington, Indiana) |
| ABSTRACT | Disclosed is a conductive ink composition and a manufacturing method thereof. The composition includes about 50 to about 99 wt % copper nanoparticles and about 1 to about 50 wt % tin. Copper nanoparticles are atomized and suspended in a tin bath, wherein the copper nanoparticles are evenly dispersed within the bath through sonification. The composition is cooled, extracted, and formed into a filament for use as a conductive ink. The ink has a resistivity of about 46.2×E-9 Ω*m to about 742.5×E-9 Ω*m. Once in filament form, the tin-copper mix will be viable for material extrusion, thus allowing for a lower cost, electrically conductive traces to be used in additive manufacturing. |
| FILED | Monday, August 22, 2022 |
| APPL NO | 17/892518 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/054 (20220101) B22F 1/145 (20220101) B22F 10/18 (20210101) Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 35/302 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/52 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230057063 | Salim et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Muhammad Ghassan Salim (Cranberry Township, Pennsylvania); Haitao Liu (Wexford, Pennsylvania); Tevis Davis Jacobs (Pittsburgh, Pennsylvania); Min A Kim (Albany, California); Luke Anthony Thimons (Natrona Heights, Pennsylvania) |
| ABSTRACT | A method of forming a fiber includes providing a sheet of a single layer of graphene or an oxidative analogue of graphene and applying force to the sheet to induce bending in the sheet and increase an aspect ratio thereof, thereby forming the fiber. |
| FILED | Thursday, February 04, 2021 |
| APPL NO | 17/796979 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/186 (20170801) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 9/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230057911 | Hugger et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vadient Optics, LLC (Beaverton, Oregon) |
| ASSIGNEE(S) | Vadient Optics, LLC (Beaverton, Oregon) |
| INVENTOR(S) | Peter G. Hugger (Eugene, Oregon); Chad N. Teters (Oregon City, Oregon); Ernst Adrian Henle (Eugene, Oregon); Thomas Leonard Allen (Milwaukie, Oregon); John Paul Harmon (Albany, Oregon); Samuel Peter Grimm (Philomath, Oregon); Edward Whitney Elliott, III (Eugene, Oregon); Peter Jon Polesnak (Eugene, Oregon) |
| ABSTRACT | A method of additively manufacturing a composite article with tuned impedance and refractive-index in three dimensions. The method includes providing a ferrite feedstock. The ferrite feedstock is loaded with ferrite particles. The method further includes depositing and curing the ferrite feedstock. Therein a composite article is formed. |
| FILED | Friday, October 07, 2022 |
| APPL NO | 18/045057 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/10 (20200101) B33Y 80/00 (20141201) Antennas, i.e Radio Aerials H01Q 15/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230058040 | NEVIUS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | HEDRON SPACE INC. (Pawtucket, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel NEVIUS (Pawtucket, Rhode Island); Anthony CLARK (Pawtucket, Rhode Island); Aidan KLUPAR (Pawtucket, Rhode Island); Joel FAURE (Pawtucket, Rhode Island); Weston Alan MARLOW (Pawtucket, Rhode Island) |
| ABSTRACT | A multi-user satellite system provides communication services to external satellites. This satellite system provides in-orbit access points that can be used by the external satellites to offload data instead on relying directly on ground stations. One approach to such communication is to use a set of interface satellites (“converter satellites”) that provide a gateway between a constellation of satellites that together provide communication services to one or more ground stations, but that do not necessarily have the communication capabilities to communicate with external satellites. In this way, the interface satellites can be put in compatible orbits with external satellites and provide communication gateways that can be used to offload data from the external satellites to ground stations. As external satellites change their communication methods, the interface satellites can be reconfigured or new compatible interface satellites can be launched, without having to modify the constellation of satellites. |
| FILED | Monday, December 07, 2020 |
| APPL NO | 17/797880 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/1007 (20130101) Transmission H04B 7/195 (20130101) H04B 7/18513 (20130101) H04B 7/18521 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230058055 | Esmaeilzadeh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hadi Esmaeilzadeh (Atlanta, Georgia); Divya Mahajan (Atlanta, Georgia); Joon Kyung Kim (Atlanta, Georgia) |
| ABSTRACT | A method for database management that includes receiving an algorithm from a user. Based on the algorithm, a hierarchical dataflow graph (hDFG) may be generated. The method may further include generating an architecture for a chip based on the hDFG. The architecture for a chip may retrieve a data table from a database. The data table may be associated with the architecture for a chip. Finally, the algorithm may be executed against the data table, such that an action included in the algorithm is performed. |
| FILED | Wednesday, October 12, 2022 |
| APPL NO | 18/045940 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/5011 (20130101) G06F 9/5038 (20130101) G06F 16/2448 (20190101) G06F 16/9024 (20190101) Computer Systems Based on Specific Computational Models G06N 5/02 (20130101) G06N 20/00 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230058070 | FUCHS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregory FUCHS (Ithaca, New York); Huiyao CHEN (Ithaca, New York) |
| ABSTRACT | Embodiments described herein provide systems and methods for acoustically driving spin rotations of diamond nitrogen-vacancy (NV) centers using acoustic transducers. The acoustic transducers may comprise devices such as bulk acoustic resonators or surface acoustic resonators. The systems and methods may allow driving of ms=0 to ms=−1, ms=0 to ms=+1, ms=−1 to ms=0, and ms=+1 to ms=0 single-quantum (SQ) spin transitions without the need to apply magnetic field pulses. This may substantially reduce the size and power requirements of NV center-based sensors. The systems and methods may be used to conduct a variety of measurements, such as measurements of magnetic field, electric field, orientation, strain, or temperature. |
| FILED | Friday, January 22, 2021 |
| APPL NO | 17/793357 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 24/10 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/34 (20130101) Impedance Networks, e.g Resonant Circuits; Resonators H03H 9/02015 (20130101) H03H 9/02582 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230058178 | Manto et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kristen Manto (University Park, Pennsylvania); John Elfar (University Park, Pennsylvania); Jagadeeshaprasad Mashanipalya Guddadarangaiah (University Park, Pennsylvania); Prem Kumar Govindappa (University Park, Pennsylvania) |
| ABSTRACT | This document relates to methods and materials for treating nerve injuries. For example, thermoresponsive compositions containing 4-aminopyridine (4-AP) and/or one or more derivatives of 4-AP as well as methods for using such thermoresponsive compositions as a delivery system for 4-AP and/or one or more derivatives of 4-AP (e.g., to treat nerve injury) are provided. This document also provides methods and materials for treating a wound (e.g., a skin wound). For example, compositions containing 4-AP and/or one or more derivatives of 4-AP can be administered (e.g., systemically administered) to a mammal having a wound (e.g., a skin wound) to treat the wound (e.g., to promote wound healing). |
| FILED | Thursday, January 21, 2021 |
| APPL NO | 17/759224 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/36103 (20130101) Original (OR) Class A61N 1/36146 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230058207 | SEIF TABRIZI et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland); Government of the United States of America, as Represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Seyed Alireza SEIF TABRIZI (Adelphi, Maryland); Mohammad HAFEZI (Washington, District of Columbia); Yi-Kai LIU (Gaithersburg, Maryland) |
| ABSTRACT | A method for detecting a two-qubit correlated dephasing error includes accessing a signal of a quantum system, where the quantum system includes a plurality of qubits. Every qubit has a nonzero rate of dephasing and some qubits have a nonzero rate of correlated dephasing. The signal further includes information about a matrix that includes diagonal elements and off-diagonal elements. The off-diagonal elements of the matrix are 2 s-sparse. The method further includes performing randomized measurements of the off-diagonal elements of the matrix and recovering the matrix based on a direct measurement of the diagonal elements of the matrix. |
| FILED | Friday, May 13, 2022 |
| APPL NO | 17/743850 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/70 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230058231 | Nadeau et al. |
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| FUNDED BY |
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| APPLICANT(S) | SRC, Inc. (North Syracuse, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Nadeau (North Syracuse, New York); John C. Dougherty (Liverpool, New York) |
| ABSTRACT | A discrete-time, digital filter for notch filtering a complex digital signal, the filter having a transfer function allowing selective filtering of complex signal components. A system for receiving a modulated signal, the system including a processor for adaptively generating filter coefficients of a discrete-time, digital filter, for filtering a complex discrete-time signal, the processor configured to (i.) identify a number of signal samples in a discrete-time signal, and use the signal samples to calculate autocorrelation values sufficient to calculate the filter coefficients, (ii.) solve a system of equations, the system of equations defined by a Toeplitz matrix and a vector to determine the coefficient values, the Toeplitz matrix defined using the autocorrelation values, and the vector defined as the autocorrelation values of a white noise signal. |
| FILED | Friday, August 20, 2021 |
| APPL NO | 17/408056 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/292 (20130101) Original (OR) Class G01S 7/354 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230058321 | Eder |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | INCLUDEHEALTH, INC. (Mason, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Ryan Eder (Columbus, Ohio) |
| ABSTRACT | Systems and methods for providing a customized exercise protocol to a computing device of a user. As the user performs the exercise protocol, one or more cameras of the computing device can track the user's movements. The user's movement are assessed to determine if proper form and technique is being used. |
| FILED | Wednesday, July 14, 2021 |
| APPL NO | 17/375518 |
| CURRENT CPC | Apparatus for Physical Training, Gymnastics, Swimming, Climbing, or Fencing; Ball Games; Training Equipment A63B 24/0006 (20130101) A63B 24/0062 (20130101) Original (OR) Class A63B 24/0075 (20130101) A63B 2024/0068 (20130101) A63B 2024/0071 (20130101) A63B 2220/05 (20130101) A63B 2220/806 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230058338 | Sahin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| INVENTOR(S) | Ozgur Sahin (New York, New York); Onur Cakmak (New York, New York); Xi Chen (New York, New York) |
| ABSTRACT | Water-responsive actuators and methods for creating water responsive actuators are disclosed. In some embodiments, the disclosed subject matter includes a first layer, for example a plastic tape, and a second layer, for example bacterial spores and cured adhesive. The second layer can be created in a pattern. The pattern can include joints, which can contract when exposed to dry air and can thereby bend the actuator, and can expand when exposed to humid air and thereby return the actuator its original position. |
| FILED | Friday, May 10, 2019 |
| APPL NO | 16/408659 |
| CURRENT CPC | Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 11/00 (20130101) Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 5/00 (20130101) C09J 11/00 (20130101) Spring, Weight, Inertia or Like Motors; Mechanical-power Producing Devices or Mechanisms, Not Otherwise Provided for or Using Energy Sources Not Otherwise Provided for F03G 7/062 (20210801) F03G 7/0613 (20210801) F03G 7/0618 (20210801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230058824 | Watts et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Analog Photonics LLC (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Watts (Hingham, Massachusetts); Ehsan Hosseini (Boston, Massachusetts); Christopher Poulton (Cambridge, Massachusetts); Erman Timurdogan (Somerville, Massachusetts) |
| ABSTRACT | An optical phase shifter may include a waveguide core that has a top surface, and a semiconductor contact that is laterally displaced relative to the waveguide core and is electrically connected to the waveguide core. A top surface of the semiconductor contact is above the top surface of the waveguide core. The waveguide core may include a p-type core region and an n-type core region. A p-type semiconductor region may be in physical contact with the n-type core region of the waveguide core, and an n-type semiconductor region may be in physical contact with the p-type core region of the waveguide core. A phase shifter region and a light-emitting region may be disposed at different depth levels, and the light-emitting region may emit light from a phase shifter region that is in a position adjacent to the light-emitting region. |
| FILED | Monday, October 31, 2022 |
| APPL NO | 17/977075 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/1223 (20130101) G02B 6/29331 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/025 (20130101) G02F 1/0151 (20210101) G02F 1/225 (20130101) Original (OR) Class G02F 1/292 (20130101) G02F 2203/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230058987 | Williams et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | David R. Williams (Chicago, Illinois); William C. NICHOLSON (Chicago, Illinois) |
| ASSIGNEE(S) | ILLINOIS INSTITUTE OF TECHNOLOGY (CHICAGO, Illinois) |
| INVENTOR(S) | David R. Williams (Chicago, Illinois); William C. NICHOLSON (Chicago, Illinois) |
| ABSTRACT | A Coanda system for controlling directions of an aircraft. The system includes a fluid passage defined in part by a casing wall having an inner surface facing the fluid passage. The fluid passage is configured to pass fluid from a first end inlet to a second end outlet. A fluid control element including a Coanda surface is disposed at the second end outlet. The fluid control element is moveable within the second end outlet to direct the fluid exiting the fluid passage between an upper gap and a lower gap, around the Coanda surface. A contour element is disposed on the inner surface of the casing wall upstream of the fluid control element, and further assists in directing the fluid to the open gap. |
| FILED | Wednesday, January 12, 2022 |
| APPL NO | 17/573830 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 21/04 (20130101) Original (OR) Class Fluid Dynamics, i.e Methods or Means for Influencing the Flow of Gases or Liquids F15D 1/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230059501 | Ramirez et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Naval Information Warfare Center Pacific (San Diego, California) |
| ASSIGNEE(S) | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (San Diego, California) |
| INVENTOR(S) | Ayax Ramirez (Chula Vista, California); Pei-Fang Wang (San Diego, California); Saurabh Sharma (San Diego, California); Ryan Lu (San Diego, California); Bienvenido Melvin L Pascoguin (La Mesa, California); Stephen D Russell (San Diego, California) |
| ABSTRACT | An underwater communication method includes creating an air column in a water body using a device including a device body, an air column-generating component, and a transceiver, thereby forming an air column to a surface of the water body. A signal is transmitted, received, or a combination of transmitted and received using the transceiver through the air column to the surface of the water body. |
| FILED | Friday, August 20, 2021 |
| APPL NO | 17/407268 |
| CURRENT CPC | Vessels for Containing or Storing Compressed, Liquefied or Solidified Gases; Fixed-capacity Gas-holders; Filling Vessels With, or Discharging From Vessels, Compressed, Liquefied, or Solidified Gases F17C 7/00 (20130101) Transmission H04B 1/38 (20130101) H04B 7/00 (20130101) H04B 13/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230059578 | Kiebish et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Berg LLC (Framingham, Massachusetts); The Henry M. Jackson Foundation for the Advancement ofMilitary Medicine (Bethesda, Maryland); Windber Research Institute (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Andrew Kiebish (Millis, Massachusetts); Albert John Kovatich (Bethesda, Maryland); Punit Shah (Hopkington, Massachusetts); Niven Rajin Narain (Cambridge, Massachusetts); Rangaprasad Sarangarajan (Boylston, Massachusetts); Guisong Wang (Bethesda, Maryland); Jeffery A. Hooke (Bethesda, Maryland); Jamie Leigh Campbell (Bethesda, Maryland); Mary Lou Cutler (Bethesda, Maryland); Craig D. Shriver (Bethesda, Maryland); Hai Hu (Windber, Pennsylvania) |
| ABSTRACT | The present invention relates to protein markers for ER-positive-like and ER-negative-like breast cancer. Methods for differentiating ER-positive-like and ER-negative-like breast cancer in a subject having breast cancer are provided, such methods including the detection of levels of a variety of biomarkers for ER-positive-like and ER-negative-like breast cancer. Compositions in the form of kits and panels of reagents for detecting the biomarkers of the invention are also provided. |
| FILED | Wednesday, April 06, 2022 |
| APPL NO | 17/714778 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/112 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57415 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230059681 | Pomeroy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sierra Space Corporation (Broomfield, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian Richard Pomeroy (Verona, Wisconsin); Martin John Chiaverini (Middleton, Wisconsin); Jesse Morgan Warrick (Madison, Wisconsin); William Zach Hallum (Madison, Wisconsin); Nicholas Ryan Walker (Madison, Wisconsin) |
| ABSTRACT | Various embodiments of a vortex hybrid motor are described herein. In some embodiments, the vortex hybrid motor may include a housing with a solid propellant positioned within the housing, and an injector ring positioned at a proximal end of the housing. The injector ring can include a plurality of angled injector units each including a first injector and a second injector angled towards an impingement point. A first fluid stream of a liquid propellant dispensed from the first injector can collide with a second fluid stream of the liquid propellant dispensed from the second injector to atomize the liquid propellant and form a spray fan formation. At least one of the first injector and the second injector can be positioned at an injection angle relative to the sidewall to create a swirl flow of the atomized injector fluid |
| FILED | Thursday, August 19, 2021 |
| APPL NO | 17/407165 |
| CURRENT CPC | Jet-propulsion Plants F02K 9/72 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230059700 | CHOI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hyeongrak CHOI (Cambridge, Massachusetts); DIRK ENGLUND (Brookline, Massachusetts) |
| ABSTRACT | Disclosed are dielectric cavity arrays with cavities formed by pairs of dielectric tips, wherein the cavities have low mode volume (e.g., 7*10−5 λ3, where λ is the resonance wavelength of the cavity array), and large quality factor Q (e.g., 106 or more). Applications for such dielectric cavity arrays include, but are not limited to, Raman spectroscopy, second harmonic generation, optical signal detection, microwave-to-optical transduction, and as light emitting devices. |
| FILED | Tuesday, May 19, 2020 |
| APPL NO | 16/878046 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5085 (20130101) B01L 2300/12 (20130101) B01L 2300/168 (20130101) B01L 2300/0654 (20130101) B01L 2300/0816 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 20/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/41 (20130101) G01N 21/65 (20130101) G01N 21/0303 (20130101) G01N 21/648 (20130101) G01N 21/6454 (20130101) Original (OR) Class G01N 2021/6463 (20130101) G01N 2201/08 (20130101) G01N 2201/067 (20130101) G01N 2201/068 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230060037 | Ozcan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Los Angeles, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Los Angeles, California) |
| INVENTOR(S) | Aydogan Ozcan (Los Angeles, California); Yair Rivenson (Los Angeles, California); Hongda Wang (Los Angeles, California); Hatice Ceylan Koydemir (Los Angeles, California); Yunzhe Qiu (Los Angeles, California) |
| ABSTRACT | A system for the detection and classification of live microorganisms in a sample includes a light source and an incubator holding one or more sample-containing growth plates. A translation stage moves the image sensor and/or the growth plate(s) along one or more dimensions to capture time-lapse holographic images of microorganisms. Image processing software executed by a computing device captures time-lapse holographic images of the microorganisms or clusters of microorganisms on the one or more growth plates. The image processing software is configured to detect candidate microorganism colonies in reconstructed, time-lapse holographic images based on differential image analysis. The image processing software includes one or more trained deep neural networks that process the time-lapsed image(s) of candidate microorganism colonies to detect true microorganism colonies and/or output a species associated with each true microorganism colony. |
| FILED | Wednesday, January 27, 2021 |
| APPL NO | 17/793926 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/04 (20130101) Optical Elements, Systems, or Apparatus G02B 21/26 (20130101) G02B 21/365 (20130101) Holographic Processes or Apparatus G03H 1/0005 (20130101) G03H 2001/005 (20130101) Image or Video Recognition or Understanding G06V 10/16 (20220101) G06V 10/82 (20220101) G06V 20/698 (20220101) Original (OR) Class Pictorial Communication, e.g Television H04N 5/2256 (20130101) H04N 5/23238 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20230053576 | Olea et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (NASHVILLE, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carlos David Olea (Nashville, Tennessee); Jules White (Nashville, Tennessee); Michael Sandborn (Nashville, Tennessee) |
| ABSTRACT | A piezoelectric container for tamper detection and damage monitoring of products within supply chains is described. The piezoelectric container enables tamper monitoring for a variety of items in transit including but not limited to those in the following sectors: medical, pharmaceutical, industrial, automotive, textiles, electronics, gems, precious metals, semiconductor chips, high value items, art, antiquities, safety critical components. For example, a sealed blister pack of prescription medicine may be stored and shipped in a piezoelectric container. The piezoelectric container can indicate tampering such as punctures, partial or total replacement of container contents, partial removal of contents, or other adverse or unwanted changes to the contents during transport. |
| FILED | Wednesday, August 17, 2022 |
| APPL NO | 17/820298 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/006 (20130101) H04L 9/3247 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230053685 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEE OF THE STEVES INSTITUTE OF TECHNOLOGY (Hoboken, New Jersey); RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (New Brunswick, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yingying Chen (Morganville, New Jersey); Jie Yang (Tallahassee, Florida); Yan Wang (Jersey City, New Jersey); Jian Liu (Jersey City, New Jersey); Marco Gruteser (Princeton, New Jersey) |
| ABSTRACT | A system includes a device that is disposed within an environment and is adapted to communicate over a radio frequency communication link. The system also includes a wireless access point disposed within the environment, including a wireless transceiver in communication with the device over a radio frequency communication link using a plurality of channels, and recording a channel state information data set for the radio frequency communication link. The system also includes a monitoring device including a memory storing a plurality of activity profiles, each of which includes an activity and a channel state information profile corresponding to the activity, and a processor receiving, from the wireless access point, the channel state information data set and determining, based on a comparison of the channel state information data set to the channel state information profile of each of the plurality of activity profiles, the activity of the person in the environment. |
| FILED | Friday, August 19, 2022 |
| APPL NO | 17/892004 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 67/306 (20130101) Original (OR) Class Wireless Communication Networks H04W 4/027 (20130101) H04W 4/029 (20180201) H04W 4/30 (20180201) H04W 88/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230054132 | XIAO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yi XIAO (Miami, Florida); Obtin ALKHAMIS (Miami, Florida); Haixiang Yu (Miami, Florida) |
| ASSIGNEE(S) | The Florida International University Board of Trustees (Miami, Florida) |
| INVENTOR(S) | Yi XIAO (Miami, Florida); Obtin ALKHAMIS (Miami, Florida); Haixiang Yu (Miami, Florida) |
| ABSTRACT | The subject invention provides materials and methods for single-step detection of target molecules in a sample. The methods and assays of the subject invention employ a dye-displacement strategy, in which aptamers complexed with a cyanine dye for sensitive and rapid detection of targets of interest. In the presence of a target, aptamer-target binding liberates the non-covalently bound aptamer-binding dye, resulting in optical changes that can be observed spectrophotometrically or with the naked eye. The methods and assays of the subject invention enable the colorimetric detection of targets of interest regardless of their structure, sequence, target-binding affinity, and physicochemical properties of their targets. |
| FILED | Saturday, August 07, 2021 |
| APPL NO | 17/396663 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/78 (20130101) G01N 33/583 (20130101) G01N 33/946 (20130101) G01N 33/948 (20130101) G01N 33/9413 (20130101) G01N 33/9486 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230054638 | HAEFFNER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Hartmut G. HAEFFNER (Oakland, California); Sara Lambert MOURADIAN (Oakland, California); Megidish Eli MAGIDASH (Oakland, California); Nicole Sarah GREENE (Oakland, California) |
| ABSTRACT | An ion gun includes a confinement vessel defining a chamber therein; a plasma source configured to provide ions in the chamber; and at least one acceleration and focusing electrode disposed within the chamber and positioned to receive ions from the plasma source, and to accelerate and focus the ions received to be delivered to an underlying surface. The at least one acceleration and focusing electrode is structured to provide an aperture therethrough to provide optical access to a high numerical aperture optical device. |
| FILED | Monday, January 04, 2021 |
| APPL NO | 17/758198 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 37/08 (20130101) H01J 37/21 (20130101) H01J 37/1471 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230055457 | MA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Teng MA (Tallahassee, Florida); Xuegang YUAN (Tallahassee, Florida); Timothy LOGAN (Tallahassee, Florida); THE FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (Tallahassee, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Teng MA (Tallahassee, Florida); Xuegang YUAN (Tallahassee, Florida); Timothy LOGAN (Tallahassee, Florida) |
| ABSTRACT | Disclosed are compositions and methods for culturing cells in a manner that inhibits culture induced senescence. In one aspect, the methods comprise the administration of nicotinamide adenine dinucleotide (NAD) precursors to the culture. Further disclosed are NAD precursors used in the methods, comprising nicotinamide (NAM), nicotinamide mononucleotide (NMN), and/or nicotinamide riboside (NR). |
| FILED | Friday, January 15, 2021 |
| APPL NO | 17/793360 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0663 (20130101) Original (OR) Class C12N 2500/38 (20130101) C12N 2500/98 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230055537 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of South Florida (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cai Mike Wang (Tampa, Florida); Sameer Varma (Tampa, Florida) |
| ABSTRACT | The present disclosure features an apparatus for identifying molecules, the apparatus including chambers configured to receive a conducting media; a membrane including a pore separating the chambers, a first set of electrodes in the chambers, a first current detector measuring an electrical signal between the first set of electrodes, a second set of electrodes electrically contacting the membrane, a second current detector configured measuring an electrical signal between the second set of electrodes, a plasmonic feature adjacent to the pore of the membrane, a light source configured to emit light onto the plasmonic feature, a light collector to collect the light scattered from the plasmonic feature, and a computing device configured to identify at least one attribute of a molecule that passes through the pore of the membrane. |
| FILED | Wednesday, August 17, 2022 |
| APPL NO | 17/890143 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 15/00 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/44791 (20130101) G01N 33/48721 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230055790 | BLACK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MASSACHUSETTS EYE AND EAR INFIRMARY (Boston, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicole Leah BLACK (Cambridge, Massachusetts); Emily DAVIDSON (Cambridge, Massachusetts); Jennifer A. LEWIS (Cambridge, Massachusetts); Aaron Kyle REMENSCHNEIDER (Boston, Massachusetts); Elliott D. KOZIN (Boston, Massachusetts) |
| ABSTRACT | Described herein are melt-extrudable biodegradable inks for 3D-printing, methods of using the inks, and kits including the inks, to prepare implantable grafts, such as artificial tympanic membrane devices or artificial cartilage, nerve conduit, tendon, muscle tissue, or bone devices. |
| FILED | Friday, December 11, 2020 |
| APPL NO | 17/784346 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) Original (OR) Class A61L 2430/14 (20130101) Compositions of Macromolecular Compounds C08L 75/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230055863 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cuberg, Inc. (San Leandro, California) |
| ASSIGNEE(S) | Cuberg, Inc. (San Leandro, California) |
| INVENTOR(S) | Richard Y. Wang (Davis, California); Jason Koeller (Redwood City, California); Olivia Risset (Oakland, California); Kaixiang Lin (San Francisco, California); Stephen Lawes (Oakland, California); Mauro Pasta (Oxford, United Kingdom) |
| ABSTRACT | A system for electrical energy production from chemical reagents in a compartmentalized cell includes: at least two electrodes, comprising at least one anode and at least one cathode; at least one separator, that separates the anodes and the cathodes; and an ionic liquid electrolyte system. The system can be a battery or one or more cells of a battery system. The ionic liquid electrolyte system comprises an ionic liquid solvent; an ether co-solvent, comprising a minority fraction, by weight, of the electrolyte; and a lithium salt. In preferred variations, the anode is a lithium metal anode and the cathode is a metal oxide cathode and the separator is a polyolefin separator. |
| FILED | Tuesday, October 11, 2022 |
| APPL NO | 18/045611 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/134 (20130101) H01M 4/382 (20130101) Original (OR) Class H01M 10/0525 (20130101) H01M 10/0567 (20130101) H01M 10/0568 (20130101) H01M 10/0569 (20130101) H01M 50/461 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230055896 | Zhu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hongli Zhu (Arlington, Massachusetts); Daxian Cao (Boston, Massachusetts) |
| ABSTRACT | Current sulfide solid-state electrolyte (SE) membranes utilized in all-solid-state lithium batteries (ASLBs) have a high thickness (0.5˜1.0 mm) and low ion conductance (<25 mS), which limit the cell-level energy and power densities. Based on ethyl cellulose's unique amphipathic molecular structure, superior thermal stability, and excellent binding capability, this work fabricated a freestanding SE membrane with an ultralow thickness of 47 μm. With ethyl cellulose as an effective disperser and binder, the Li6PS5Cl is uniformly dispersed in toluene and possesses superior film formability. In addition, ultralow areal resistance of 5.10 Ωcm−2 and remarkable ion conductance of 190.11 mS (one order higher than the conventional sulfide SE layer) have been achieved. The ASLB assembled with this SE membrane delivers cell-level high gravimetric and volumetric energy densities of 175 Wh kg−1 and 675 Wh L−1, individually. |
| FILED | Thursday, August 18, 2022 |
| APPL NO | 17/820662 |
| CURRENT CPC | Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 15/006 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2006/40 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/054 (20130101) H01M 10/0525 (20130101) H01M 10/0562 (20130101) Original (OR) Class H01M 2300/008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230055980 | Ding et al. |
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| FUNDED BY |
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| APPLICANT(S) | Kaize Ding (Tempe, Arizona); Huan Liu (Tempe, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on Behalf of Arizona State University (Tempe, Arizona) |
| INVENTOR(S) | Kaize Ding (Tempe, Arizona); Huan Liu (Tempe, Arizona) |
| ABSTRACT | Various embodiments of systems and methods for inductive anomaly detection on attributed networks using a graph neural layer to learn anomaly-aware node representations and further employ generative adversarial learning to detect anomalies among new data are disclosed herein. |
| FILED | Wednesday, May 11, 2022 |
| APPL NO | 17/742236 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/088 (20130101) G06N 3/0454 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230056031 | Lee et al. |
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| FUNDED BY |
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| APPLICANT(S) | Lumicell, Inc. (Newton, Massachusetts) |
| ASSIGNEE(S) | Lumicell, Inc. (Newton, Massachusetts) |
| INVENTOR(S) | W. David Lee (Brookline, Massachusetts); Jorge Ferrer (West Newton, Massachusetts); David Benjamin Strasfeld (Somerville, Massachusetts) |
| ABSTRACT | Embodiments related to medical imaging devices including rigid imaging tips and their methods of use for identifying abnormal tissue within a surgical bed are disclosed. |
| FILED | Thursday, September 01, 2022 |
| APPL NO | 17/901649 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0071 (20130101) A61B 5/0075 (20130101) A61B 5/0086 (20130101) A61B 5/0091 (20130101) Original (OR) Class A61B 5/4312 (20130101) A61B 5/6886 (20130101) A61B 10/0041 (20130101) A61B 90/361 (20160201) A61B 2090/309 (20160201) A61B 2505/05 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 49/0032 (20130101) A61K 49/0056 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230056032 | RAITHEL et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| INVENTOR(S) | Georg A. RAITHEL (Ann Arbor, Michigan); Alisher DUSPAYEV (Ann Arbor, Michigan) |
| ABSTRACT | A method is presented for measuring motion of a moving body using an atom interferometer. The method includes: positioning at least one atom in a cavity of the atom interferometer, where the atom interferometer is attached to the moving body; splitting the at least one atom into a pair of wave-function components; guiding the pair of wave-function components along respective paths in the cavity such that the pair of wave-function components are confined spatially along the respective paths in all degrees of freedom and without interruption; coherently recombining the pair of wave-function components into the at least one atom; and measuring a property of the at least one atom after the pair of wave-function components have been recombined into the at least one atom, where the property of the at least one atom is indicative of motion of the moving body. |
| FILED | Friday, August 19, 2022 |
| APPL NO | 17/891673 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 19/58 (20130101) Measuring Linear or Angular Speed, Acceleration, Deceleration, or Shock; Indicating Presence, Absence, or Direction, of Movement G01P 15/093 (20130101) Techniques for Handling Particles or Ionising Radiation Not Otherwise Provided For; Irradiation Devices; Gamma Ray or X-ray Microscopes G21K 1/006 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230056315 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University, Northeastern Univ. (Boston, Massachusetts); College of William & Mary (Williamsburg, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yanzhi Wang (Newton Highlands, Massachusetts); Peiyan Dong (Boston, Massachusetts); Zhengang Li (Boston, Massachusetts); Bin Ren (Jamestown, Virginia); Wei Niu (Jamestown, Virginia) |
| ABSTRACT | A recurrent neural network (RNN) acceleration framework leverages both a block-based pruning approach and compiler optimizations to accelerate RNN inference on mobile devices. |
| FILED | Monday, January 25, 2021 |
| APPL NO | 17/795145 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/082 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230056985 | Cotrufo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Colorado State University Research Foundation (Fort Collins, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | M. Francesca Cotrufo (Fort Collins, Colorado); Yao Zhang (Fort Collins, Colorado); Andrew Robertson (Fort Collins, Colorado); Jocelyn Lavallee (Fort Collins, Colorado); Keith H. Paustian (Fort Collins, Colorado); Stephen Ogle (Fort Collins, Colorado) |
| ABSTRACT | A microbial efficiency-matrix stabilization (MEMS) 2.0 ecosystem model, with detailed pools and fluxes for the litter and soil components, represents carbon (C) and nitrogen (N) fluxes among atmosphere, plants, and soil, in multiple soil layers down to a user-defined depth. Inputs and recycling of N cause feedbacks to net primary productivity (NPP), which is allocated aboveground (ANPP) or belowground (BNPP) and at different depths, depending on vegetation and soil traits. |
| FILED | Wednesday, August 18, 2021 |
| APPL NO | 17/405289 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/20 (20200101) Original (OR) Class G06F 2111/10 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230057500 | Marty et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Marty (Tucson, Arizona); James Keener (Tucson, Arizona); Guozhi Zhang (Tucson, Arizona) |
| ABSTRACT | An automated system for lipid exchange-mass spectrometry, e.g., measuring affinity of a membrane protein for lipids. The automated systems herein can measure the specificity of membrane protein-lipid interactions, detect remodeling of the membrane environment, and determine optimal lipid composition for membrane proteins. |
| FILED | Thursday, February 04, 2021 |
| APPL NO | 17/796054 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/30 (20130101) G01N 30/7233 (20130101) Original (OR) Class G01N 33/58 (20130101) G01N 33/92 (20130101) G01N 35/0099 (20130101) G01N 2030/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230058055 | Esmaeilzadeh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hadi Esmaeilzadeh (Atlanta, Georgia); Divya Mahajan (Atlanta, Georgia); Joon Kyung Kim (Atlanta, Georgia) |
| ABSTRACT | A method for database management that includes receiving an algorithm from a user. Based on the algorithm, a hierarchical dataflow graph (hDFG) may be generated. The method may further include generating an architecture for a chip based on the hDFG. The architecture for a chip may retrieve a data table from a database. The data table may be associated with the architecture for a chip. Finally, the algorithm may be executed against the data table, such that an action included in the algorithm is performed. |
| FILED | Wednesday, October 12, 2022 |
| APPL NO | 18/045940 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/5011 (20130101) G06F 9/5038 (20130101) G06F 16/2448 (20190101) G06F 16/9024 (20190101) Computer Systems Based on Specific Computational Models G06N 5/02 (20130101) G06N 20/00 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230058622 | LUBINSKY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (Albany, New York); UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (Knoxville, Tennessee); GEORGIA TECH RESEARCH CORPORATION (Atlanta, Georgia) |
| ASSIGNEE(S) | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (Albany, New York); UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (Knoxville, Tennessee); GEORGIA TECH RESEARCH CORPORATION (Atlanta, Georgia) |
| INVENTOR(S) | Anthony R. LUBINSKY (Port Jefferson, New York); Adrian HOWANSKY (Centereach, New York); Jacqueline JOHNSON (Tullahoma, Tennessee); Meredith Brooke BECKERT (Atlanta, Georgia); Charles BOND (Tullahoma, Tennessee) |
| ABSTRACT | Scintillating glass ceramics are disclosed. The scintillating glass ceramics may be used as an x-ray conversion layer (screen) for a flat panel imager (FPD) and as part of an imaging system. The FPD may have a single screen or a dual screen. The scintillating glass ceramics may be used for either a front screen or a back screen. The scintillating glass ceramics may be used for high energy x-ray applications including for energies of about 0.3 to about 20 MeV. A build-up layer may be attached to the scintillating glass ceramics for high energy applications. The scintillating glass ceramics may include a glass matrix hosting luminescent centers and light scattering centers. The materials used for the luminescent centers and light scattering centers may be the same or different. The scintillating glass ceramics may be coated onto a glass substrate. |
| FILED | Friday, January 22, 2021 |
| APPL NO | 17/790087 |
| CURRENT CPC | Measurement of Nuclear or X-radiation G01T 1/2002 (20130101) G01T 1/20188 (20200501) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230058997 | ZHU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for The State University of New York (Amherst, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lingxiang ZHU (Amherst, New York); Liang HUANG (Amherst, New York); Mark SWIHART (Williamsville, New York); Haiqing LIN (Buffalo, New York) |
| ABSTRACT | Provided are composite articles having a membrane and a porous substrate, where the porous substrate has the membrane disposed thereon. The membrane has two layers, where the first layer has the second layer disposed thereon, and each layer has a plurality of polymer chains with a plurality of silicon-oxygen groups and a plurality of silicon-carbon groups. The first layer has a silicon to oxygen ratio of about 4:1 to about 1:1.25 and a silicon to carbon ratio of about 1:2 to about 1:10, and the second layer has a silicon to oxygen ratio of about 1:1 to about 1:2 and a silicon to carbon ratio of about 2:1 to about 10:1. At least a portion of the polymer chains of the second layer am crosslinked. The composite articles may be used in gas separation methods. Also provided are methods of making the composite articles and devices utilizing the composite articles. |
| FILED | Tuesday, January 19, 2021 |
| APPL NO | 17/759038 |
| CURRENT CPC | Separation B01D 53/228 (20130101) B01D 61/027 (20130101) B01D 67/009 (20130101) B01D 69/02 (20130101) B01D 69/10 (20130101) B01D 69/125 (20130101) Original (OR) Class B01D 69/1214 (20220801) B01D 71/70 (20130101) B01D 71/701 (20220801) B01D 2256/16 (20130101) B01D 2256/18 (20130101) B01D 2257/504 (20130101) B01D 2257/702 (20130101) B01D 2323/12 (20130101) B01D 2323/30 (20130101) B01D 2323/385 (20130101) B01D 2325/04 (20130101) B01D 2325/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20230053638 | Custelcean et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Radu Custelcean (Beavercreek, Ohio); Bruce A. Moyer (Oak Ridge, Tennessee); Jeffrey Einkauf (Knoxville, Tennessee) |
| ABSTRACT | A compound having the following structure: wherein: R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are independently selected from (i) hydrogen atom, (ii) hydrocarbon groups (R) containing 1-30 carbon atoms and optionally substituted with one or more fluorine atoms, (iii) —OR′ groups, (iv) —NR′2 groups, (v) —C(O)R′ groups, and (vi) halogen atoms, wherein R′ groups are independently selected from R groups and hydrogen atoms, and wherein the R group optionally includes a C(O), ether, or amino linkage; Xm− is an anionic species with a magnitude of charge m, where m is an integer of at least 1; and n is a number, provided that n×m=1. Also described herein are methods for removing one or more oxyanions from a liquid source by use of the above compound or mono-pyridyl derivative thereof. |
| FILED | Thursday, July 28, 2022 |
| APPL NO | 17/875767 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/54 (20130101) Original (OR) Class C02F 2101/101 (20130101) Heterocyclic Compounds C07D 213/53 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230054368 | Li |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Fermi Research Alliance, LLC (Batavia, Illinois) |
| ASSIGNEE(S) | Fermi Research Alliance, LLC (Batavia, Illinois) |
| INVENTOR(S) | Shaorui Li (East Setauket, New York) |
| ABSTRACT | A digital-to-analog converter circuit that creates an analog waveform from an input digital waveform. Operating the circuit comprises using the input digital waveform to 1) operate a charge control switch to set a charge time period, 2) operate a discharge control switch to set a discharge time period, 3) set a charge current magnitude using a charge gain, and 4) set a discharge current magnitude using a discharge gain. A charge source electrically charges a load capacitor during the charge time period (i.e., the charge mode). A discharge source electrically discharges the load capacitor during the discharge time period (i.e., the discharge mode). A circuit output transmits the analog waveform defined by the charge mode and the discharge mode. A charge current magnitude greater than the discharge current magnitude produces an upward-sloping analog waveform. A charge current magnitude less than the discharge current magnitude produces a downward-sloping analog waveform. |
| FILED | Monday, August 23, 2021 |
| APPL NO | 17/409780 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Coding; Decoding; Code Conversion in General H03M 1/70 (20130101) H03M 1/661 (20130101) H03M 1/806 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230054822 | Beer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | N. Reginald Beer (Pleasanton, California); Steven Bond (Livermore, California); Peter C. Haugen (Livermore, California); Jacob Trueblood (Dublin, California); Brian Matthew Wihl (Pleasanton, California) |
| ABSTRACT | A GPR system the implements a modified multistatic mode of operation is provided. The GPR is suitable for mounting on an unmanned aerial vehicle. The GPR system has radar transceivers. The GPR system transmits transmit signal serially via the transceivers. For each transceiver that transmits a transmit signal, the GPR system receives a return signal acquired by each transceiver except for a return signal for the transceiver that transmits the transmit signal. The GPR system outputs of matrix of return signals that includes a null value for the return signals of the transceivers that transmit. |
| FILED | Friday, January 31, 2020 |
| APPL NO | 16/779339 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/40 (20130101) Original (OR) Class G01S 13/885 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230055863 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cuberg, Inc. (San Leandro, California) |
| ASSIGNEE(S) | Cuberg, Inc. (San Leandro, California) |
| INVENTOR(S) | Richard Y. Wang (Davis, California); Jason Koeller (Redwood City, California); Olivia Risset (Oakland, California); Kaixiang Lin (San Francisco, California); Stephen Lawes (Oakland, California); Mauro Pasta (Oxford, United Kingdom) |
| ABSTRACT | A system for electrical energy production from chemical reagents in a compartmentalized cell includes: at least two electrodes, comprising at least one anode and at least one cathode; at least one separator, that separates the anodes and the cathodes; and an ionic liquid electrolyte system. The system can be a battery or one or more cells of a battery system. The ionic liquid electrolyte system comprises an ionic liquid solvent; an ether co-solvent, comprising a minority fraction, by weight, of the electrolyte; and a lithium salt. In preferred variations, the anode is a lithium metal anode and the cathode is a metal oxide cathode and the separator is a polyolefin separator. |
| FILED | Tuesday, October 11, 2022 |
| APPL NO | 18/045611 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/134 (20130101) H01M 4/382 (20130101) Original (OR) Class H01M 10/0525 (20130101) H01M 10/0567 (20130101) H01M 10/0568 (20130101) H01M 10/0569 (20130101) H01M 50/461 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230055900 | Terao |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SunPower Corporation (San Jose, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Akira Terao (San Jose, California) |
| ABSTRACT | Metallization and stringing methods for back-contact solar cells, and resulting solar cells, are described. In an example, in one embodiment, a method involves aligning conductive wires over the back sides of adjacent solar cells, wherein the wires are aligned substantially parallel to P-type and N-type doped diffusion regions of the solar cells. The method involves bonding the wires to the back side of each of the solar cells over the P-type and N-type doped diffusion regions. The method further includes cutting every other one of the wires between each adjacent pair of the solar cells. |
| FILED | Thursday, November 03, 2022 |
| APPL NO | 17/980440 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/0504 (20130101) Original (OR) Class H01L 31/022441 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230056242 | Spahn |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Fermi Research Alliance, LLC (Batavia, Illinois) |
| ASSIGNEE(S) | Fermi Research Alliance, LLC (Batavia, Illinois) |
| INVENTOR(S) | Gabriel Spahn (Rapid City, South Dakota) |
| ABSTRACT | Epoxy-based inline infrared (IR) filter assembly, and manufacture and use of the same. Co-axial infrared filter assemblies comprise a substantially cylindrical filter body forming a central cavity characterized by opposing holes at each end. The filter body forms an outer conductor, and SMA connectors coupled to the opposing holes at each end of the body are electrically coupled to form an inner conductor positioned along a long axis of the filter body. An infrared absorbing material (such as castable epoxy resin) fills the central cavity of the filter body. Methods for producing the co-axial infrared filter include pressing SMA connectors into the respective ends of the filter body, electrically coupling the SMA connectors, and filling the filter body with epoxy. Electronic systems for operating a dark matter detector include a feedline comprising a coaxial filter configured to advantageously block infrared noise. |
| FILED | Tuesday, August 17, 2021 |
| APPL NO | 17/405013 |
| CURRENT CPC | Measurement of Nuclear or X-radiation G01T 1/1606 (20130101) Optical Elements, Systems, or Apparatus G02B 1/04 (20130101) G02B 5/208 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230056452 | Westpheling et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (Athens, Georgia); UT-BATTELLE, LLC (Oak Ridge, Tennessee); THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (Knoxville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Janet Westpheling (Bogart, Georgia); Adam M. Guss (Knoxville, Tennessee); Lauren A. Riley (Lakewood, Colorado) |
| ABSTRACT | This disclosure describes recombinant Megasphaera microbes designed to include increased consumption of acetate, increased carbon flux to butyryl-CoA and/or hexanoyl-CoA, increased production of butyrate and/or hexanoate, or a combination thereof, than a comparable control. This disclosure also describes methods that generally include growing such recombinant microbes under conditions effective for the recombinant microbes to consume greater amounts of acetate, produce increased amounts of butyryl-CoA and/or hexanoyl-CoA, produce increased amounts of butyrate and/or hexanoate, or a combination thereof. |
| FILED | Tuesday, August 09, 2022 |
| APPL NO | 17/884269 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0008 (20130101) C12N 9/88 (20130101) C12N 9/1033 (20130101) C12N 15/52 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230056985 | Cotrufo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Colorado State University Research Foundation (Fort Collins, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | M. Francesca Cotrufo (Fort Collins, Colorado); Yao Zhang (Fort Collins, Colorado); Andrew Robertson (Fort Collins, Colorado); Jocelyn Lavallee (Fort Collins, Colorado); Keith H. Paustian (Fort Collins, Colorado); Stephen Ogle (Fort Collins, Colorado) |
| ABSTRACT | A microbial efficiency-matrix stabilization (MEMS) 2.0 ecosystem model, with detailed pools and fluxes for the litter and soil components, represents carbon (C) and nitrogen (N) fluxes among atmosphere, plants, and soil, in multiple soil layers down to a user-defined depth. Inputs and recycling of N cause feedbacks to net primary productivity (NPP), which is allocated aboveground (ANPP) or belowground (BNPP) and at different depths, depending on vegetation and soil traits. |
| FILED | Wednesday, August 18, 2021 |
| APPL NO | 17/405289 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/20 (20200101) Original (OR) Class G06F 2111/10 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230057265 | FLACH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BATTELLE SAVANNAH RIVER ALLIANCE, LLC (Alken, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | JOSHUA P. FLACH (AIKEN, South Carolina); KURT R. EBERL (AIKEN, South Carolina); WILLIAM R. JOHNSON (AIKEN, South Carolina) |
| ABSTRACT | In one aspect, a compact augmented permeation system (CAPS) assembly includes a housing defining an interior cavity. The housing further defines a gas inlet for receiving gas within the interior cavity and a gas outlet for expelling the gas from the interior cavity. Additionally, the CAPS assembly includes a gas-permeable membrane positioned within the housing and defining a system boundary across the interior cavity such that gas received within the interior cavity via the gas inlet permeates through the gas-permeable membrane before being expelled from the interior cavity via the gas outlet. |
| FILED | Wednesday, June 15, 2022 |
| APPL NO | 17/840754 |
| CURRENT CPC | Containers for Storage or Transport of Articles or Materials, e.g Bags, Barrels, Bottles, Boxes, Cans, Cartons, Crates, Drums, Jars, Tanks, Hoppers, Forwarding Containers; Accessories, Closures, or Fittings Therefor; Packaging Elements; Packages B65D 39/08 (20130101) B65D 51/24 (20130101) B65D 51/1616 (20130101) Original (OR) Class B65D 2205/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230058348 | Sakshaug et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Group14 Technologies, Inc. (Woodinville, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Avery Sakshaug (Snohomish, Washington); Henry R. Costantino (Woodinville, Washington); Aaron M. Feaver (Seattle, Washington); Leah A. Thompkins (Seattle, Washington); Katharine Geramita (Seattle, Washington); Benjamin E. Kron (Seattle, Washington); Sarah Fredrick (Denver, Colorado); Farshid Afkhami (Lake Stevens, Washington); Adam Strong (Lake Forest Park, Washington) |
| ABSTRACT | Composites of silicon and various porous scaffold materials, such as carbon material comprising micro-, meso- and/or macropores, and methods for manufacturing the same are provided. The compositions find utility in various applications, including electrical energy storage electrodes and devices comprising the same. |
| FILED | Wednesday, August 17, 2022 |
| APPL NO | 17/890197 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/524 (20130101) C04B 38/0051 (20130101) C04B 38/0064 (20130101) C04B 41/009 (20130101) C04B 41/85 (20130101) C04B 41/5096 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/04 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/133 (20130101) H01M 4/134 (20130101) H01M 4/362 (20130101) H01M 4/364 (20130101) H01M 4/366 (20130101) H01M 4/386 (20130101) H01M 4/0416 (20130101) H01M 4/587 (20130101) Original (OR) Class H01M 4/625 (20130101) H01M 10/0525 (20130101) H01M 2004/021 (20130101) H01M 2220/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230058668 | Roberts et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Andrew Roberts (Wellesley, Massachusetts); Tony M. Brewer (Plano, Texas) |
| ABSTRACT | A cache memory can maintain multiple cache lines and each cache line can include a data field, an encryption status attribute, and an encryption key attribute. The encryption status attribute can indicate whether the data field in the corresponding cache line includes encrypted or unencrypted data and the encryption key attribute can include an encryption key identifier for the corresponding cache line. In an example, a cryptographic controller can access keys from a key table to selectively encrypt or unencrypt cache data. Infrequently accessed cache data can be maintained as encrypted data, and more frequently accessed cache data can be maintained as unencrypted data. In some examples, different cache lines in the same cache memory can be maintained as encrypted or unencrypted data, and different cache lines can use respective different encryption keys. |
| FILED | Friday, June 17, 2022 |
| APPL NO | 17/843571 |
| CURRENT CPC | Electric Digital Data Processing G06F 12/0842 (20130101) G06F 12/1408 (20130101) Original (OR) Class G06F 2212/62 (20130101) G06F 2212/1052 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230058736 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho); The Research Foundation for the State University of New York (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bin Li (Idaho Falls, Idaho); Erik J. Dufek (Ammon, Idaho); Peter G. Khalifah (Upton, New York) |
| ABSTRACT | A current collector is disclosed and comprises a conductive material and an elemental metal of a group 6 metal contacting the conductive material. Also disclosed are an electrochemical cell comprising a current collector, a cathode adjacent to the current collector, and an alkali metal-based electrolyte between the current collector and the cathode, with the cathode separated from the group 6 metal by the alkali metal-based electrolyte. A method of operating the electrochemical cell is also disclosed. |
| FILED | Tuesday, August 16, 2022 |
| APPL NO | 17/819993 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/74 (20130101) H01M 4/625 (20130101) H01M 4/626 (20130101) H01M 4/661 (20130101) Original (OR) Class H01M 10/058 (20130101) H01M 10/0525 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230058740 | Lynch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Lynch (Durham, North Carolina); Romel Menacho Melgar (Durham, North Carolina) |
| ABSTRACT | Provide herein are engineered microbial strains having greatly improved expression of many challenging protein product. This system relies on controlled expression or dynamic reduction in activity of key housekeeping proteases. Dynamic control, implemented with CRISPR based gene silencing and or controlled protein degradation enables increased protein expression while minimizing the negative impact of complete deletions of these housekeeping enzymes. |
| FILED | Thursday, August 11, 2022 |
| APPL NO | 17/819100 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/70 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230058997 | ZHU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for The State University of New York (Amherst, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lingxiang ZHU (Amherst, New York); Liang HUANG (Amherst, New York); Mark SWIHART (Williamsville, New York); Haiqing LIN (Buffalo, New York) |
| ABSTRACT | Provided are composite articles having a membrane and a porous substrate, where the porous substrate has the membrane disposed thereon. The membrane has two layers, where the first layer has the second layer disposed thereon, and each layer has a plurality of polymer chains with a plurality of silicon-oxygen groups and a plurality of silicon-carbon groups. The first layer has a silicon to oxygen ratio of about 4:1 to about 1:1.25 and a silicon to carbon ratio of about 1:2 to about 1:10, and the second layer has a silicon to oxygen ratio of about 1:1 to about 1:2 and a silicon to carbon ratio of about 2:1 to about 10:1. At least a portion of the polymer chains of the second layer am crosslinked. The composite articles may be used in gas separation methods. Also provided are methods of making the composite articles and devices utilizing the composite articles. |
| FILED | Tuesday, January 19, 2021 |
| APPL NO | 17/759038 |
| CURRENT CPC | Separation B01D 53/228 (20130101) B01D 61/027 (20130101) B01D 67/009 (20130101) B01D 69/02 (20130101) B01D 69/10 (20130101) B01D 69/125 (20130101) Original (OR) Class B01D 69/1214 (20220801) B01D 71/70 (20130101) B01D 71/701 (20220801) B01D 2256/16 (20130101) B01D 2256/18 (20130101) B01D 2257/504 (20130101) B01D 2257/702 (20130101) B01D 2323/12 (20130101) B01D 2323/30 (20130101) B01D 2323/385 (20130101) B01D 2325/04 (20130101) B01D 2325/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230059113 | Yang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GM Global Technology Operations LLC (Detroit, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jianghuai Yang (Rochester Hills, Michigan); Qigui Wang (Rochester Hills, Michigan); Anil K. Sachdev (Rochester Hills, Michigan) |
| ABSTRACT | A cast steel alloy for an engine of a vehicle is provided. The cast steel alloy comprises 0.29 to 0.65 weight percent (wt %) carbon, 0.40 to 0.80 wt % silicon, 0.6 to 1.5 wt % manganese, up to 0.03 wt % phosphorus, 0.04 to 0.07 wt % sulfur, 0.8 to 1.4 wt % chromium, 0.2 to 0.6 wt % nickel, 0.15 to 0.55 wt % molybdenum, 0.25 to 2.0 wt % copper, up to 0.03 wt % titanium, 0.07 to 0.17 wt % vanadium, 0.02 to 0.06 wt % aluminum, up to 0.03 wt % nitrogen (N), and 0.01 to 0.06 wt % of at least one of cerium (Ce) and lanthanum. The cast steel alloy has unexpected and unconventional results such as reduced ferrite and enhanced strengths. |
| FILED | Friday, August 20, 2021 |
| APPL NO | 17/407884 |
| CURRENT CPC | Casting of Metals; Casting of Other Substances by the Same Processes or Devices B22D 29/04 (20130101) Original (OR) Class Modifying the Physical Structure of Ferrous Metals; General Devices for Heat Treatment of Ferrous or Non-ferrous Metals or Alloys; Making Metal Malleable, e.g by Decarburisation or Tempering C21D 2211/005 (20130101) Alloys C22C 38/001 (20130101) C22C 38/02 (20130101) C22C 38/04 (20130101) C22C 38/005 (20130101) C22C 38/06 (20130101) C22C 38/42 (20130101) C22C 38/44 (20130101) C22C 38/46 (20130101) C22C 38/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230059151 | SNEAD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (Albany, New York) |
| ASSIGNEE(S) | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (Albany, New York) |
| INVENTOR(S) | Lance SNEAD (Stony Brook, New York); David SPROUSTER (Port Jefferson, New York); Jason TRELEWICZ (Stony Brook, None) |
| ABSTRACT | Composite structures are provided whose composite matrix is a fully-dense (greater than 95%) magnesium oxide-containing phase and whose entrained phase, by virtue of its' decomposition temperature or chemical reactivity, would otherwise not be fabricable. Notably, a methodology is provided whereby a range of composite structures are formed by applying an advanced manufacturing technique and a blend of ceramic powder whose sintering is enhanced by small amounts of a metal halide sintering aid. This methodology and process significantly lowers the processing temperature of refractory ceramics such as magnesium oxide allowing formation of ceramic bodies incorporating phases such as metal hydrides, fragile ceramic phases, and highly reactive species such as beryllides. In all cases, the final product is substantially-free, or even devoid, of the metal halide sintering aid, resulting in a phase-pure ceramic matrix composed of the host phase and the entrained phase. |
| FILED | Thursday, January 21, 2021 |
| APPL NO | 17/790086 |
| CURRENT CPC | Nuclear Reactors G21C 3/64 (20130101) Original (OR) Class G21C 21/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230059561 | Chakraborty et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Indrasis Chakraborty (Pittsburg, California); Jhi Young Joo (Oakland, California) |
| ABSTRACT | A system to enable identification of arcing hazards comprises a data storage to store a set of measurements acquired by measurement units of a power distribution system. The system further comprises at least one processor configured to identify candidate arcing events represented by the measurements by using an unsupervised machine learning process, and to train a supervised machine learning classifier for automatic real-time identification of arcing events, by using labeled training data based on the identified candidate arcing events. |
| FILED | Monday, August 15, 2022 |
| APPL NO | 17/819905 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/52 (20200101) G01R 31/1227 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20230053493 | Kleinfeld et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alan Marc Kleinfeld (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alan Marc Kleinfeld (La Jolla, California); Andrew H. Huber (La Jolla, California); Hiroto Kameyama (La Jolla, California); Tung-Chih Sun (La Jolla, California); Divya Subramonian (La Jolla, California) |
| ABSTRACT | Identification and use of proteins fluorescently labeled and that undergo a change in fluorescence index upon binding bilirubin are described. Probes are disclosed which are labeled at a cysteine or lysine residue and also probes labeled at both cysteine and lysine with two different fluorophores. These probes are useful for determination of unbound bilirubin levels in a fluid sample. |
| FILED | Thursday, August 27, 2020 |
| APPL NO | 17/632202 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/72 (20130101) Original (OR) Class G01N 33/582 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230055740 | Wick et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CAMERAD TECHNOLOGIES (Decatur, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carson A. Wick (Decatur, Georgia); Srini Tridandapani (Decatur, Georgia) |
| ABSTRACT | Methods for co-registering images of different imaging modalities include obtaining a photograph and a medical image, maximizing mutual information between the photograph and the medical image, automatically locating features common to both the photograph and the medical image based on maximized mutual information between the photograph and the medical image, and automatically highlighting the located features within the photograph or medical image. |
| FILED | Friday, September 09, 2022 |
| APPL NO | 17/942052 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230057285 | Zhamu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Global Graphene Group, Inc. (Dayton, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aruna Zhamu (Springboro, Ohio); Hui He (Dayton, Ohio); Bor Z. Jang (Centerville, Ohio) |
| ABSTRACT | The disclosure provides a multi-layer prelithiated anode including (a) a conducting substrate having a first primary surface and a second primary surface; (b) a first layer of lithium metal deposited onto the first primary surface of the conducting substrate; (c) a first graphitic layer that substantially covers the first lithium metal layer; and (d) a first anode active layer deposited on a primary surface of the first graphitic layer. The first anode active layer includes an anode active material. Also provided are a lithium battery including such a prelithiated anode and a method of producing such an anode. |
| FILED | Friday, August 13, 2021 |
| APPL NO | 17/402188 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/133 (20130101) H01M 4/134 (20130101) H01M 4/366 (20130101) Original (OR) Class H01M 4/587 (20130101) H01M 10/0525 (20130101) H01M 2004/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20230056241 | Nejad et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (East Lansing, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mojgan Nejad (Okemos, Michigan); Sasha Bell (Brooklyn, New York); Mohsen Siahkamari (East Lansing, Michigan) |
| ABSTRACT | The disclosure relates to adhesive compositions, including non-crosslinked resins and crosslinked/cured adhesives joining substrates, as well as related methods for making the compositions and articles. Compared to a conventional phenol (P) and formaldehyde (F) resin, the disclosed methods and compositions use lignin (L) and higher aldehydes (A) as corresponding replacements to provide an analog to a conventional PF resin with biobased reactants. Due to the differing reactivity of the LA components compared to the PF components, the initial condensation reaction between ortho-reactive sites in the lignin and the aldehyde is controlled to prevent gelation of the aqueous reaction mixture while reacting substantially all of the LA reactants to provide a non-crosslinked resin reaction product. The resin reaction product can then be cured at high temperature/high pressure conditions to provide a crosslinked adhesive, for example joining two substrates. |
| FILED | Friday, January 22, 2021 |
| APPL NO | 17/793093 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 8/04 (20130101) Derivatives of Natural Macromolecular Compounds C08H 6/00 (20130101) Original (OR) Class Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 197/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230056428 | Chen |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jian Chen (Greenville, Mississippi) |
| ABSTRACT | Disclosed herein are compositions for attracting fire ants wherein the compositions contain at least one fire ant food source, and at least one of 10-oxo-dodecanoic acid, 11-oxo-dodecanoic acid, or a mixture thereof, and optionally a carrier. Disclosed are also methods for attracting fire ants, the methods involving treating an object or area with a fire ant-attracting effective amount of a composition of the invention. |
| FILED | Wednesday, August 03, 2022 |
| APPL NO | 17/879968 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 25/006 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20230058207 | SEIF TABRIZI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland); Government of the United States of America, as Represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Seyed Alireza SEIF TABRIZI (Adelphi, Maryland); Mohammad HAFEZI (Washington, District of Columbia); Yi-Kai LIU (Gaithersburg, Maryland) |
| ABSTRACT | A method for detecting a two-qubit correlated dephasing error includes accessing a signal of a quantum system, where the quantum system includes a plurality of qubits. Every qubit has a nonzero rate of dephasing and some qubits have a nonzero rate of correlated dephasing. The signal further includes information about a matrix that includes diagonal elements and off-diagonal elements. The off-diagonal elements of the matrix are 2 s-sparse. The method further includes performing randomized measurements of the off-diagonal elements of the matrix and recovering the matrix based on a direct measurement of the diagonal elements of the matrix. |
| FILED | Friday, May 13, 2022 |
| APPL NO | 17/743850 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/70 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230059433 | Lecocq et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Florent Lecocq (Boulder, Colorado); Josue Davila-Rodriguez (Boulder, Colorado); Franklyn John Quinlan (Longmont, Colorado); John Teufel (Erie, Colorado); Scott A. Diddams (Louisville, Colorado); Jose Aumentado (Boulder, Colorado) |
| ABSTRACT | An operational environment is disclosed herein that includes a cryogenic environment and a signal source. The cryogenic environment includes a signal target, an optical link, signal converter devices, and an electrical link. Outside of the cryogenic environment, the signal source generates an electric signal. An electric-to-optical converter converts the electrical signal into an optical signal. The optical link delivers the optical signal into the cryogenic environment. Inside the cryogenic environment, an optical-to-electrical converter converts the optical signal back into an electrical signal. The optical-to-electrical converter transfers the electric signal to the signal target. |
| FILED | Wednesday, May 11, 2022 |
| APPL NO | 17/742252 |
| CURRENT CPC | Transmission H04B 10/70 (20130101) Original (OR) Class H04B 10/25759 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20230056032 | RAITHEL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| INVENTOR(S) | Georg A. RAITHEL (Ann Arbor, Michigan); Alisher DUSPAYEV (Ann Arbor, Michigan) |
| ABSTRACT | A method is presented for measuring motion of a moving body using an atom interferometer. The method includes: positioning at least one atom in a cavity of the atom interferometer, where the atom interferometer is attached to the moving body; splitting the at least one atom into a pair of wave-function components; guiding the pair of wave-function components along respective paths in the cavity such that the pair of wave-function components are confined spatially along the respective paths in all degrees of freedom and without interruption; coherently recombining the pair of wave-function components into the at least one atom; and measuring a property of the at least one atom after the pair of wave-function components have been recombined into the at least one atom, where the property of the at least one atom is indicative of motion of the moving body. |
| FILED | Friday, August 19, 2022 |
| APPL NO | 17/891673 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 19/58 (20130101) Measuring Linear or Angular Speed, Acceleration, Deceleration, or Shock; Indicating Presence, Absence, or Direction, of Movement G01P 15/093 (20130101) Techniques for Handling Particles or Ionising Radiation Not Otherwise Provided For; Irradiation Devices; Gamma Ray or X-ray Microscopes G21K 1/006 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230058067 | Pan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GENERAL ELECTRIC COMPANY (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Di Pan (Schenectady, New York); Yichao Zhang (Guilderland, New York); Yuntao Xu (Clifton Park, New York); Yukai Wang (Glenville, New York) |
| ABSTRACT | A power converter apparatus comprises a set of switching elements communicatively coupled with a set of gate drive circuits. Each gate drive circuit is configured to provide a respective drive signal to a corresponding switching element, each switching element being switchably responsive to the respective drive signal. The apparatus includes a controller module configured to control an output state of the power converter, and selectively change one of a respective gate resistance and a respective gate current of a corresponding subset of the gate drive circuits based on the output state of the power converter. |
| FILED | Friday, August 13, 2021 |
| APPL NO | 17/401402 |
| CURRENT CPC | Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/08 (20130101) Original (OR) Class H02M 7/487 (20130101) H02M 7/5395 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20230060122 | Striker et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Todd Striker (Madison, Wisconsin); Nathan Joseph Wlodarchak (Madison, Wisconsin); John Bruce Feltenberger (Madison, Wisconsin); Jennifer Golden (Waunakee, Wisconsin) |
| ABSTRACT | Biochemically active PASTA kinase inhibitors which exploit subtle structural differences between human kinases and bacterial PASTA kinases to improve specificity and inhibitor activity. The disclosed kinase inhibitors have the general formula: wherein: R1=Me, Et, n-Pr, —CH2CH2OH, —CH2CH2OP(O)(OH)2, —CH2CH2NMe2; R2=H, Me, Et, o-Pr, i-Pr, CF3, Cl, OMe; R3=H, Me, NHMe, NHBn, Cl, NO2OMe, F, CN; and Ar= |
| FILED | Wednesday, February 10, 2021 |
| APPL NO | 17/172314 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/496 (20130101) A61K 31/506 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/06 (20180101) Heterocyclic Compounds C07D 239/42 (20130101) C07D 277/28 (20130101) C07D 401/04 (20130101) Original (OR) Class C07D 417/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Security Agency (NSA)
| US 20230057021 | Huang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hewlett Packard Enterprise Development LP (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhihong Huang (Milpitas, California); Di Liang (Santa Barbara, California); Yuan Yuan (Milpitas, California) |
| ABSTRACT | A device may include: a highly doped n+ Si region; an intrinsic silicon multiplication region disposed on at least a portion of the n+ Si region, the intrinsic silicon multiplication having a thickness of about 90-110 nm; a highly doped p− Si charge region disposed on at least part of the intrinsic silicon multiplication region, the p− Si charge region having a thickness of about 40-60 nm; and a p+ Ge absorption region disposed on at least a portion of the p− Si charge region; wherein the p+ Ge absorption region is doped across its entire thickness. The thickness of the n+ Si region may be about 100 nm and the thickness of the p− Si charge region may be about 50 nm. The p+ Ge absorption region may confine the electric field to the multiplication region and the charge region to achieve a temperature stability of 4.2 mV/° C. |
| FILED | Monday, May 23, 2022 |
| APPL NO | 17/664462 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/1446 (20130101) H01L 31/028 (20130101) H01L 31/105 (20130101) Original (OR) Class H01L 31/1804 (20130101) Transmission H04B 10/66 (20130101) Multiplex Communication H04J 14/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Non-Profit Organization (NPO)
| US 20230053718 | DiMarino et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (Blacksburg, Virginia); University of Nottingham (Nottingham, United Kingdom) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christina DiMarino (Arlington, Virginia); Mark Cairnie (Blacksburg, Virginia); Dushan Boroyevich (Alexandria, Virginia); Rolando Burgos (Blacksburg, Virginia); C. Mark Johnson (Nottingham, United Kingdom) |
| ABSTRACT | A number of different sealed interfaces for power modules are described. In one example, a sealed interface includes a printed circuit board including a contact pad for power conduction to a bus bar of the printed circuit board, a semiconductor module including at least one power transistor, a terminal pin electrically coupled to the power module, and a housing for the power module. The housing includes an open terminal aperture that extends through the housing. The printed circuit board is seated upon the open terminal aperture, to close and seal the open terminal aperture, with the contact pad positioned within the open terminal aperture. The terminal pin contacts the contact pad of the printed circuit board within the open terminal aperture, and the open terminal aperture comprises a transitional feature to abate electric field intensity around an interface between the open terminal aperture and the printed circuit board. |
| FILED | Wednesday, August 18, 2021 |
| APPL NO | 17/405653 |
| CURRENT CPC | Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/184 (20130101) H05K 5/0095 (20130101) H05K 7/1457 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20230057843 | Bombaugh |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott R. Bombaugh (Burke, Virginia) |
| ABSTRACT | Embodiments of a system and method for sorting and sequencing articles in a processing facility are disclosed. Delivery endpoints are divided and grouped into stop groups. A first sorter sorts items according to stop group and outputs the items to trays. The output trays from the first sorter are loaded to a second sorter in stop group order. The second sorter can then sort the items into output bins in delivery sequence order. |
| FILED | Monday, October 10, 2022 |
| APPL NO | 18/045389 |
| CURRENT CPC | Postal Sorting; Sorting Individual Articles, or Bulk Material Fit to be Sorted Piece-meal, e.g by Picking B07C 1/025 (20130101) B07C 3/008 (20130101) Original (OR) Class B07C 3/10 (20130101) B07C 3/14 (20130101) B07C 2301/0041 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20230053890 | Bethune et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Donald Stimson Bethune (San Jose, California); Charles Thomas Rettner (San Jose, California) |
| ABSTRACT | A structure that includes a signal trace embedded in a dielectric layer, the signal trace including a first contact pad at one end of the signal trace and a second contact pad at the other end of the signal trace. The dielectric layer has a first ground plane on a first surface and a second ground plane on a second opposing surface. A first conducting ground shield wall on a first side of the signal trace connects the first ground plane to the second ground plane. A second conducting ground shield wall on a second side of the signal trace connects the first ground plane to the second ground plane. The first ground plane, the second ground plane, the first conducting ground shield wall, and the second conducting ground shield wall enclose the signal trace. |
| FILED | Tuesday, August 17, 2021 |
| APPL NO | 17/445257 |
| CURRENT CPC | Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 1/047 (20130101) H01P 3/081 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230054073 | Huang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NEUROQUEST LTD. (Misgav Business Park, Israel) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xin Huang (Mernda, Australia); Yihan Li (Parkville, Australia); Christopher Fowler (Mooroolbark, Australia); James Doecke (Tamborine, Australia); Colin L. Masters (Clifton Hill, Australia); Baijun Gu (Mernda, Australia) |
| ABSTRACT | Compositions and kits for diagnosing and prognosing Alzheimer's Disease (AD) in a human patient include a binding agent such as a monoclonal antibody for a biomarker conjugated to a detectable moiety such as a fluorophore, wherein the biomarker is chosen from CD163, CD91, CD59, MerTK and other phagocytosis-related molecules. Further compositions and kits employ panels of fluorophore-conjugated monoclonal antibodies for biomarkers including scavenger receptors. Methods for determining the relative expression of biomarkers, diagnosing AD, and determining the efficacy of AD therapeutic candidates such as phagocytosis-promoting agents and scavenger receptor agonists also appear. |
| FILED | Monday, August 08, 2022 |
| APPL NO | 17/882671 |
| CURRENT CPC | Peptides C07K 16/2803 (20130101) C07K 2317/30 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/582 (20130101) Original (OR) Class G01N 33/6896 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230054793 | Kumph |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Muir Kumph (Croton on Hudson, New York) |
| ABSTRACT | An apparatus comprising an interposer mounted to a conductive holder and a plurality of microwave cavities, wherein each microwave cavity of the plurality of microwave cavities is comprised of a fin section having two sidewalls, wherein each sidewall is comprised of a vane that extends up from the conductive holder through the interposer. |
| FILED | Tuesday, August 17, 2021 |
| APPL NO | 17/445259 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/66 (20130101) H01L 23/49838 (20130101) H01L 2223/6627 (20130101) Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 7/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230054950 | Shealy |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Shealy (Cincinnati, Ohio) |
| ABSTRACT | In some embodiments, apparatuses are provided herein useful to sealing a gap between a movable flap and stationary structure, such as a gap between a gas turbine engine nozzle flap and sidewall. An apparatus for sealing such a gap may be a plunger seal which may include a plurality of plunger segments connected together using at least one flexure. When positioned in the gap, the flexures within the plunger segments pivot allowing rotation of each of the plurality of plunger segments about their respective pivot point, such that the plunger assembly seals and contours against the movable surface. |
| FILED | Friday, August 20, 2021 |
| APPL NO | 17/407439 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 11/005 (20130101) F01D 25/30 (20130101) Jet-propulsion Plants F02K 1/805 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2240/55 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230055096 | KIM et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SEOUL NATIONAL UNIVERSITY R and DB FOUNDATION (Seoul, South Korea) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ju-Kon KIM (Gangwon-do, South Korea); Jun Sung SEO (Gangwon-do, South Korea); Jae Sung SHIM (Gwangju, South Korea); Sung Hwan KIM (Seoul, South Korea) |
| ABSTRACT | The present invention relates to OsNF-YA5 gene from Oryza sativa for increasing nitrogen availability of plant and uses thereof. Since the OsNF-YA5 gene of the present invention can increase or improve nitrogen availability of a plant, it can be advantageously used for developing a plant which enables lesser consumption of nitrogen fertilizer while maintaining the same plant yield, i.e., an environment friendly plant with lower production cost. |
| FILED | Tuesday, August 03, 2021 |
| APPL NO | 17/392841 |
| CURRENT CPC | New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 4/008 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8262 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230055258 | Rodbell |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenneth P. Rodbell (Sandy Hook, Connecticut) |
| ABSTRACT | A method comprising cleaning the top surface of a silicon substrate and forming a diffusion barrier by depositing a metal on top the top surface of the silicon substrate. The diffusion barrier is formed one monolayer at a time and wherein the diffusion barrier will have a height of about 1 to 3 nm. Forming a layer of crystalline Niobium on top of the diffusion barrier. |
| FILED | Tuesday, August 17, 2021 |
| APPL NO | 17/445263 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 39/12 (20130101) H01L 39/223 (20130101) H01L 39/2406 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230056913 | Bethune et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Donald Stimson Bethune (San Jose, California); Charles Thomas Rettner (San Jose, California) |
| ABSTRACT | An embodiment of the invention may include a spliced stripline structure. The structure may include a first stripline including a signal line located between a top dielectric and a bottom dielectric. The top dielectric is in contact with a top ground plane. The bottom dielectric is in contact with a bottom ground plane. The structure may include a second stripline including a signal line located between a top dielectric and a bottom dielectric. The top dielectric is in contact with a top ground plane. The bottom dielectric is in contact with a bottom ground plane. The structure may include a joined portion connecting the first stripline to the second stripline. The joined portion the first stripline includes the bottom ground plane, the bottom dielectric, and at least one signal line. The joined portion the first stripline includes the bottom ground plane, the bottom dielectric, and at least one signal line. |
| FILED | Tuesday, August 17, 2021 |
| APPL NO | 17/445264 |
| CURRENT CPC | Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 3/08 (20130101) Original (OR) Class H01P 11/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230058638 | Abraham et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Abraham (Croton, New York); Gerard McVicker (Stormville, New York); Sri M. Sri-Jayantha (Ossining, New York); Vijayeshwar Das Khanna (Milwood, New York); Kathryn Jessica Pooley (Croton on Hudson, New York); Ricardo Alves Donaton (Cortlandt Manor, New York) |
| ABSTRACT | A die stack that includes a first chip die, a second chip die connected to the first chip die by one or more controlled collapse chip connection (“C4”) solder bump bonds, and a spacer die interposed between the first and second chip dies. The spacer die includes through holes for the one or more C4 solder bumps, and has a thickness such that when the first and second chip dies are compressed into contact with the spacer die, the spacer die thickness is a minimum defined spacing between the first and second chip dies, and the spacer die operates as a hard stop against compression of the die stack after the first and second chip dies are compressed into contact with the spacer die. |
| FILED | Tuesday, August 17, 2021 |
| APPL NO | 17/445254 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 24/11 (20130101) H01L 24/16 (20130101) H01L 24/81 (20130101) Original (OR) Class H01L 25/0657 (20130101) H01L 2224/10125 (20130101) H01L 2224/10135 (20130101) H01L 2224/11015 (20130101) H01L 2224/16147 (20130101) H01L 2224/81139 (20130101) H01L 2224/81208 (20130101) H01L 2924/384 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230058897 | Abraham et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Abraham (Croton, New York); Gerard McVicker (Stormville, New York); Sri M. Sri-Jayantha (Ossining, New York) |
| ABSTRACT | Embodiments of a present invention disclose an apparatus including a silicon wafer and a through-silicon-via (TSV) filled with a thermally conductive material located in the silicon wafer, wherein the thermally conductive material has better thermal conduction properties than the silicon wafer when at cryogenic temperatures. A shunt layer connected to the thermal material in the TSV and a heat generating device located directly on top of the thermal material in the TSV and directly on top of the shunt layer, wherein the heat generated by the heat generating device is removed directly by the shunt layer and the thermal material in the TSV. |
| FILED | Tuesday, August 17, 2021 |
| APPL NO | 17/445248 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/3677 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230059594 | Gibson |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gerald W. Gibson (Danbury, Connecticut) |
| ABSTRACT | The method that includes the step of a cleaning a surface of a silicon wafer and forming a sacrificial layer on top of the silicon wafer. The wafer undergoes further processing, wherein the processing includes forming at least one layer directly on top of the sacrificial layer. Immediately prior to the insertion into a dilute refrigeration unit removing a portion of the sacrificial layer by exposing the portion of the sacrificial layer to a solvent. |
| FILED | Tuesday, August 17, 2021 |
| APPL NO | 17/445246 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/02043 (20130101) H01L 21/28238 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230059927 | Johnson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Ryan Johnson (Fairfield, Ohio); Paul Hadley Vitt (Liberty Twp, Ohio); Eric Joseph Schroeder (Loveland, Ohio); Carlos Gilberto Fernandez-Soto (Fairfield Twp, Ohio) |
| ABSTRACT | A turbine engine and method of operating includes an engine core with a compressor, a combustor, and a turbine in axial flow arrangement. A flow path extends through the engine core from the compressor to the turbine to define a flow direction for a working airflow through the engine core. |
| FILED | Wednesday, November 02, 2022 |
| APPL NO | 17/979057 |
| CURRENT CPC | Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/24 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, February 23, 2023.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
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You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20230223.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
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