FedInvent™ Patent Applications
Application Details for Thursday, March 09, 2023
This page was updated on Thursday, March 09, 2023 at 01:04 PM GMT
Department of Health and Human Services (HHS)
| US 20230069843 | Heath et al. |
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| FUNDED BY |
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| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James R. Heath (Pasadena, California); Songming Peng (San Mateo, California); Alphonsus Hon-Chung Ng (Pasadena, California) |
| ABSTRACT | Compositions and methods for identifying antigen-specific T cells, including determining paired T cell receptor sequences for a specific antigen, are described. Compositions and methods for identifying neoantigen-specific T cells are also described. Microfluidic devices useful for identifying antigen-specific T cells, and methods of using the same, are also described. |
| FILED | Thursday, March 08, 2018 |
| APPL NO | 16/492588 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) B01L 2200/0652 (20130101) B01L 2300/0864 (20130101) B01L 2400/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1037 (20130101) Original (OR) Class C12N 15/1055 (20130101) C12N 15/1065 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230069905 | Eisenberg et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | David S. Eisenberg (Los Angeles, California); Smriti Sangwan (Los Angeles, California); Lin Jiang (Santa Monica, California) |
| ABSTRACT | This invention relates to inhibitory peptides which bind to α-synuclein molecules and inhibit α-synuclein amyloidogenic aggregation, α-synuclein cytotoxicity, and spread of α-synuclein. Methods of making and using the inhibitory peptides (e.g. to treat subjects having conditions or diseases that are mediated by α-synuclein, such as Parkinson's disease, dementia with Lewy bodies, or MSA) are described. |
| FILED | Friday, June 24, 2022 |
| APPL NO | 17/848736 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/16 (20180101) Peptides C07K 7/02 (20130101) Original (OR) Class C07K 7/08 (20130101) C07K 14/47 (20130101) C07K 14/4711 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230069973 | Cruttenden et al. |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
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| INVENTOR(S) | Corey Edward Cruttenden (Minneapolis, Minnesota); Rajesh Rajamani (Saint Paul, Minnesota); Wei Chen (Plymouth, Minnesota); Xiao-Hong Zhu (Plymouth, Minnesota); Mahdi Ahmadi (Minneapolis, Minnesota) |
| ABSTRACT | A device includes a substrate, an electrode, an electrical pad, and a signal line. The signal line is coupled to the substrate and covered by an insulation layer. The signal line is coupled to the electrical pad and the electrode. At least one of the electrode and the signal line includes a diamagnetic material and paramagnetic material, wherein a ratio of the diamagnetic material and the paramagnetic material is selected based on the susceptibility properties of a physiological tissue. The term paramagnetic herein refers to magnetic susceptibility greater than that of the surrounding tissue and diamagnetic refers to magnetic susceptibility lower than that of the tissue. |
| FILED | Tuesday, August 16, 2022 |
| APPL NO | 17/820115 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/24 (20210101) A61B 5/6868 (20130101) A61B 5/6877 (20130101) A61B 5/7207 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/086 (20170801) A61N 1/0534 (20130101) Original (OR) Class A61N 1/0551 (20130101) A61N 1/36103 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230070047 | Yuan |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shauna Yuan (Edina, Minnesota) |
| ABSTRACT | A method to enhance homology directed recombination (HDR) efficiency, and a kit therefor, are provided. |
| FILED | Wednesday, July 06, 2022 |
| APPL NO | 17/811048 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 35/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0696 (20130101) C12N 9/22 (20130101) C12N 15/102 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230070049 | Junn et al. |
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| FUNDED BY |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | Eunsung Junn (East Brunswick, New Jersey); Mary M. Mouradian (Princeton, New Jersey); Myung-Sik Yoo (New Brunswick, New Jersey) |
| ABSTRACT | Compositions, recombinant viral vectors, recombinant viruses, and nanoparticles for treating a subject having a spinal cord injury include a therapeutically effective amount of a nucleic acid sequence encoding pre-microRNA-7 (pre-miR-7). Methods of using these compositions, recombinant viral vectors, recombinant viruses, and nanoparticles are also described herein. These compositions, recombinant viral vectors, recombinant viruses, and nanoparticles and methods of use provide novel therapies for SCI based on the discovery that miR-7 expression provides neuroprotection and recovery of locomotor function in subjects having SCI. |
| FILED | Monday, February 01, 2021 |
| APPL NO | 17/759832 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2310/141 (20130101) C12N 2330/51 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230070180 | LINDSEY et al. |
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| APPLICANT(S) | West Virginia University Board of Governors on behalf of West Virginia University (Morgantown, West Virginia) |
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| INVENTOR(S) | BROCK A. LINDSEY (Morgantown, West Virginia); Justin E MARKEL (Pittsburgh, Pennsylvania); Ryan A LACINSKI (Bridgeville, Pennsylvania); Jabeen NOORE (Kingsville, Texas) |
| ABSTRACT | The present disclosure provides compositions comprising protein encapsulated nanoparticles, and methods of making said compositions. In an aspect, a composition may comprise a drug delivery vector and a therapeutic substance, wherein the composition elutes at least 1.0 pg of the therapeutic substance per 100,000 particles of the drug delivery vector over a period of time under conditions of a drug delivery vector release buffer, wherein the therapeutic substance, drug delivery vector and drug delivery vector release buffer comprise a solution, wherein the solution is centrifuged and a portion stored at about 1 to 10° C., and wherein the elution of the therapeutic substance is determined by ELISA assay. This disclosure further describes a method of controlling an immunophenotype in a patient suffering from a disease which impacts the immune system. |
| FILED | Thursday, June 02, 2022 |
| APPL NO | 17/830615 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5153 (20130101) A61K 31/43 (20130101) A61K 31/7036 (20130101) A61K 38/208 (20130101) A61K 47/62 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230070316 | Knight et al. |
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| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina); UNIVERSITY OF MIAMI COLLEGE OF ENGINEERING (Coral Gables, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | O'Rese J. Knight (Chapel Hill, North Carolina); Devin K. Hubbard (Chapel Hill, North Carolina); Noel Marysa Ziebarth (Coral Gables, Florida) |
| ABSTRACT | Devices for determining one or more corneal biomechanical properties are described herein which, in some embodiments, exhibit the versatility for continuous and intermittent patient monitoring. In some embodiments, a device comprises at least one self-sensing cantilever calibrated against a control of known biomechanical properties, wherein the self-sensing cantilever is coupled to a base configured to position the self-sensing cantilever adjacent to a corneal surface. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/799100 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/16 (20130101) Original (OR) Class Spectacles; Sunglasses or Goggles Insofar as They Have the Same Features as Spectacles; Contact Lenses G02C 7/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230070399 | Walter et al. |
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| APPLICANT(S) | The Regents of The University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nils Walter (Ann Arbor, Michigan); Alexander Johnson-Buck (Brighton, Massachusetts); Mario Blanco (Pasadena, California); Arlie Rinaldi (Pasadena, California) |
| ABSTRACT | Provided herein is technology relating to detecting and identifying nucleic acids and particularly, but not exclusively, to compositions, methods, kits, and systems for detecting, identifying, and quantifying target nucleic acids with high confidence at single-molecule resolution. |
| FILED | Tuesday, September 06, 2022 |
| APPL NO | 17/929809 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6816 (20130101) C12Q 1/6837 (20130101) Original (OR) Class C12Q 1/6886 (20130101) C12Q 2600/178 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230070477 | Tsang et al. |
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| APPLICANT(S) | THE TRUSTEES OF CULUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen H. Tsang (New York, New York); Xuan Cui (New York, New York); Nan-Kai Wang (New York, New York); Pei-Kang Liu (New York, New York) |
| ABSTRACT | The present disclosure relates to methods and compounds for reprogramming metabolism in one specific retinal and neuronal cell type leading to improved cell and tissue survival and function. In particular, the present disclosure relates to increasing PGC1α/Pgc1α or NRF2/Nrf2 or inhibiting HIF/Hif or KEAP1/Keap1 to reprogram metabolism and survival of cells in a variety of neurodegenerative conditions, and specifically those which cause blindness. |
| FILED | Monday, February 08, 2021 |
| APPL NO | 17/760152 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 15/111 (20130101) C12N 2310/14 (20130101) C12N 2750/14143 (20130101) C12N 2830/008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230070595 | Balint et al. |
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| APPLICANT(S) | Etubics Corporation (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph P. Balint (Seattle, Washington); Frank R. Jones (Seattle, Washington); Richard B. Gayle, III (Seattle, Washington) |
| ABSTRACT | Methods for generating immune responses using adenovirus vectors that allow multiple vaccinations with the same adenovirus vector and vaccinations in individuals with preexisting immunity to adenovirus are provided. |
| FILED | Monday, November 14, 2022 |
| APPL NO | 17/986424 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/191 (20130101) A61K 38/193 (20130101) A61K 38/204 (20130101) A61K 38/208 (20130101) A61K 38/217 (20130101) A61K 38/2013 (20130101) A61K 38/2026 (20130101) A61K 38/2033 (20130101) A61K 38/2046 (20130101) A61K 38/2066 (20130101) A61K 39/00 (20130101) A61K 39/0011 (20130101) A61K 39/12 (20130101) Original (OR) Class A61K 39/21 (20130101) A61K 39/235 (20130101) A61K 39/001106 (20180801) A61K 39/001182 (20180801) A61K 2039/54 (20130101) A61K 2039/57 (20130101) A61K 2039/545 (20130101) A61K 2039/575 (20130101) A61K 2039/5256 (20130101) A61K 2039/55555 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/005 (20130101) C07K 14/71 (20130101) C07K 14/70503 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2710/10034 (20130101) C12N 2710/10321 (20130101) C12N 2710/10334 (20130101) C12N 2710/10343 (20130101) C12N 2710/10371 (20130101) C12N 2710/20034 (20130101) C12N 2740/15034 (20130101) C12N 2740/16234 (20130101) C12N 2800/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230070600 | Abdallah et al. |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut); The United states of America as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chadi Abdallah (New Haven, Connecticut); John Krystal (New Haven, Connecticut); Ronald Duman (New Haven, Connecticut); Gerard Sanacora (New Haven, Connecticut) |
| ABSTRACT | The present invention provides compositions and methods for treating diseases or disorders using a therapeutically effective amount of a rapid-acting antidepressant (RAAD) and a therapeutically effective amount of a mTOR inhibitor and/or immunosuppressant. In certain embodiments, the RAAD and the mTOR inhibitor and/or immunosuppressant are part of a single pharmaceutical composition. |
| FILED | Tuesday, October 25, 2022 |
| APPL NO | 18/049589 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/08 (20130101) A61K 9/0053 (20130101) A61K 31/135 (20130101) A61K 31/436 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/24 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230071283 | Golosov et al. |
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| APPLICANT(S) | Andrei Golosov (, None); Carla Patricia Pinto Guimaraes (, None); Gregory Motz (, None); Michael C. Milone (, None); Christoph T. Ellebrecht (, None); Aimee S. Payne (, None); Novartis AG (, None); The Trustees of the University of Pennsylvania (, None) |
| ASSIGNEE(S) | Aimee S. Payne (Philadelphia, Pennsylvania); Aimee S. Payne (Basel, Switzerland); Aimee S. Payne (Philadelphia, Pennsylvania); Andrei Golosov (Cambridge, Massachusetts); Carla Patricia Pinto Guimaraes (Cambridge, Massachusetts); Gregory Patricia Pinto Motz (Quincy, Massachusetts); Michael C. Milone (Cherry Hill, New Jersey); Christoph T. Ellebrecht (Philadelphia, Pennsylvania); Aimee S. Payne (Merion Station, Pennsylvania) |
| INVENTOR(S) | Andrei Golosov (Cambridge, Massachusetts); Carla Patricia Pinto Guimaraes (Boston, Massachusetts); Gregory Motz (Quincy, Massachusetts); Michael C. Milone (Cherry Hill, New Jersey); Christoph T. Ellebrecht (Philadelphia, Pennsylvania); Aimee S. Payne (Merion Station, Pennsylvania) |
| ABSTRACT | Provided herein are fusion proteins including two protein domains separated by a heterologous protease cleavage site, wherein a first of the protein domains is a conditional expression domain. Thus, the fusion proteins comprise three essential elements: a conditional expression domain, a domain containing the protein of interest, and a protease cleavage domain separating the two. Also provided herein are methods for treating autoantibody and alloantibody-mediated diseases or conditions in a subject by targeting B cells with anti-B cell modified T cells. In one embodiment, a chimeric antigen receptor (CAR) modified T cell is selectively ablated in a subject after adoptive transfer. Pharmaceutical compositions comprising the temporally regulated CAR modified T cell are also described herein. |
| FILED | Friday, April 14, 2017 |
| APPL NO | 16/093758 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/7051 (20130101) Original (OR) Class C07K 2319/03 (20130101) C07K 2319/50 (20130101) C07K 2319/70 (20130101) C07K 2319/95 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230071308 | LONGEST et al. |
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| APPLICANT(S) | Virginia Commonwealth University (Richmond, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Worth LONGEST (Richmond, Virginia); Connor HOWE (Richmond, Virginia); Dale FARKAS (Richmond, Virginia); Sarah STRICKLER (Richmond, Virginia); Vijaya RANI (Richmond, Virginia); Ahmad EL-ACHWAY (Richmond, Virginia) |
| ABSTRACT | Proposed devices operate on positive pressure with as little as 5-6 ml of air and can efficiently empty (emitted doses >80%) and deliver the aerosol to infant lungs (lung delivery efficiency of ˜60% of the loaded dose). Significant features include internal flow structure of the air-jet DPI, automatic gas sources, infant-specific interfaces, small diameter nasopharyngeal tubes, sealed nasal prongs, 3D rod array preceding patient interface, nasal CPAP rapid aerosol delivery system, nasal CPAP streamlined interface, multidose storage and delivery unit, and pressure sensing near the infant airways (at the nasal cannula interface). |
| FILED | Friday, January 22, 2021 |
| APPL NO | 17/794875 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 15/08 (20130101) A61M 15/0045 (20130101) Original (OR) Class A61M 15/0086 (20130101) A61M 2202/064 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230071386 | Kim et al. |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
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| INVENTOR(S) | Nam Sung Kim (Champaign, Illinois); Mohammad Alian (Urbana, Illinois) |
| ABSTRACT | A computing device includes a host processor to execute a host driver to create a host-side interface, the host-side interface emulating a first Ethernet interface, assign the host-side interface a first medium access control (MAC) address and a first Internet Protocol (IP) address. Memory components are disposed on a substrate. A memory channel network (MCN) processor is disposed on the substrate and coupled between the memory components and the host processor. The MCN processor is to execute an MCN driver to create a MCN-side interface, the MCN-side interface emulating a second Ethernet interface. The MCN processor is to assign the MCN-side interface a second MAC address and a second IP address, which identify the MCN processor as a MCN network node to the host processor. |
| FILED | Friday, November 04, 2022 |
| APPL NO | 17/980685 |
| CURRENT CPC | Electric Digital Data Processing G06F 12/10 (20130101) G06F 13/1673 (20130101) G06F 13/4027 (20130101) Original (OR) Class G06F 2212/1016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230071507 | Richards et al. |
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| APPLICANT(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chris Richards (Versailles, Kentucky); Jill Kolesar (Lexington, Kentucky) |
| ABSTRACT | Compositions and methods described in this document make use of macrophage derived engineered vesicles (MEV) having specificity for delivery to a target environment, for use in modifying macrophage phenotype and/or treating a condition. Further disclosed are MEV derived from a specific phenotype encapsulating a therapeutic agent for targeted therapeutic delivery. |
| FILED | Thursday, February 11, 2021 |
| APPL NO | 17/799082 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5068 (20130101) Original (OR) Class A61K 35/15 (20130101) A61K 35/28 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0645 (20130101) C12N 2501/24 (20130101) C12N 2501/052 (20130101) C12N 2501/2304 (20130101) C12N 2501/2314 (20130101) C12N 2502/1157 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230071935 | Bomsztyk et al. |
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| FUNDED BY |
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| APPLICANT(S) | Matchstick Technologies, Inc. (Kirkland, Washington); University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karol Bomsztyk (Mercer Island, Washington); Gregory P. Darlington (Snohomish, Washington); Daniel S. Mar (Seattle, Washington); Thomas J. Matula (Kirkland, Washington); Gregory T. Wing (Bellevue, Washington) |
| ABSTRACT | A sonicator assembly, including: a microplate defining a plurality of wells; a manifold for containing a transducer fluid that is thermally coupled to the plurality of wells of the microplate; an ultrasonic generator operable for applying an ultrasonic excitation to the wells of the microplate; one or more of a heating module thermally coupled to and operable for selectively heating the transducer fluid and a cooling module thermally coupled to and operable for selectively cooling the transducer fluid; and a controller operable for controlling operation of the ultrasonic generator and the one or more of the heating module and the cooling module. The controller is further operable for monitoring a temperature and a pressure within the manifold. A temperature of the plurality of wells is controllable over a temperature range from 4° C. to 95° C. Optionally, the plurality of wells include a plurality of heat-resistant round-bottom hydrophilic wells. |
| FILED | Wednesday, August 10, 2022 |
| APPL NO | 17/884705 |
| CURRENT CPC | Separation B01D 21/283 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/10 (20130101) Original (OR) Class Methods or Apparatus for Generating or Transmitting Mechanical Vibrations of Infrasonic, Sonic, or Ultrasonic Frequency, for Performing Mechanical Work in General B06B 1/0622 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/4077 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230072362 | Schmuck et al. |
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| FUNDED BY |
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| APPLICANT(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric Schmuck (Madison, Wisconsin); Amish Raval (Madison, Wisconsin); Sushmita Roy (Madison, Wisconsin); Tianhua Zhou (Madison, Wisconsin) |
| ABSTRACT | The disclosure generally relates to methods, cells, and compositions for preparing cardiac extracellular matrix. In particular, provided herein are methods for preparing a cardiac extracellular matrix using SUSD2 High fibroblasts and SUSD2 High myofibroblasts. |
| FILED | Tuesday, September 06, 2022 |
| APPL NO | 17/929890 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/12 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/3633 (20130101) Original (OR) Class A61L 27/3834 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0657 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230072399 | ZHAO et al. |
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| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbs, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kai ZHAO (Dublin, Ohio); Kanghyun KIM (Columbus, Ohio) |
| ABSTRACT | A nasal plug includes a first tube having a first wall forming a first lumen of a first diameter. The first tube has a first tube proximal end in a proximal plane and a distal end in a distal plane. The nasal plug further includes a second tube that includes a second wall forming a second lumen of a second diameter, the second diameter smaller than the first diameter. A channel is formed by the second lumen and extends from the first tube proximal end into the first lumen of the first tube. The second tube also includes a flexible wall having a free end within the first lumen. The flexible wall is movable within the first lumen and has a length sufficient to touch a surface of the first lumen and fluidically seal the first lumen between the flexible wall and the surface of the first lumen. The second tube includes a channel proximal end in a channel proximal end plane. The channel proximal end plane is at an angle with respect to the distal plane of the first tube. |
| FILED | Friday, February 19, 2021 |
| APPL NO | 17/801154 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 5/08 (20130101) Original (OR) Class Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 16/0672 (20140204) A61M 2210/0618 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230072400 | Bajpai et al. |
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| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shivam Bajpai (Tempe, Arizona); Jianming Liang (Scottsdale, Arizona) |
| ABSTRACT | Described herein are means for generating pre-trained models for nnU-Net through the use of improved transfer learning techniques, in which the pre-trained models are then utilized for the processing of medical imaging. According to a particular embodiment, there is a system specially configured for segmenting medical images, in which such a system includes: a memory to store instructions; a processor to execute the instructions stored in the memory; wherein the system is specially configured to: execute instructions via the processor for executing a pre-trained model from Models Genesis within a nnU-Net framework; execute instructions via the processor for learning generic anatomical patterns within the executing Models Genesis through self-supervised learning; execute instructions via the processor for transforming an original image using distortion and cutout-based methods; execute instructions via the processor for learning the reconstruction of the original image from the transformed image using an encoder-decoder architecture of the nnU-Net framework to identify the generic anatomical representation from the transformed image by recovering the original image; and wherein architecture determined by the nnU-Net framework is utilized with Models Genesis and is trained to minimize the L2 distance between the prediction and ground truth. Other related embodiments are disclosed. |
| FILED | Wednesday, September 07, 2022 |
| APPL NO | 17/939783 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30096 (20130101) Image or Video Recognition or Understanding G06V 10/467 (20220101) G06V 10/768 (20220101) G06V 10/7715 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230072425 | ADIE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven G ADIE (Ithaca, New York); Yuechuan LIN (Ithaca, New York); Nichaluk LEARTPRAPUN (Ithaca, New York) |
| ABSTRACT | Disclosed are devices and techniques based on optical coherence tomography (OCT) technology in combination with optical actuation. A system for providing optical actuation and optical sensing can include an optical coherence tomography (OCT) device that performs optical imaging of a sample based on optical interferometry from an optical sampling beam interacting with an optical sample and an optical reference beam; an OCT light source to provide an OCT imaging beam into the OCT device which splits the OCT imaging beam into the optical sampling beam and the optical reference beam; and a light source that produces an optical actuation beam that is coupled along with the optical sampling beam to be directed to the sample to actuate particles or structures in the sample so that the optical imaging captures information of the sample under the optical actuation. |
| FILED | Monday, February 01, 2021 |
| APPL NO | 17/759851 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0066 (20130101) Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/02007 (20130101) G01B 9/02012 (20130101) G01B 9/02034 (20130101) G01B 9/02091 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/17 (20130101) G01N 21/6486 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230072606 | Langer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert S. Langer (Newton, Massachusetts); Ana Jaklenec (Lexington, Massachusetts); Joseph Collins (Boston, Massachusetts); Morteza Sarmadi (Cambridge, Massachusetts); Aurelien vander Straeten (Cambridge, Massachusetts); Maria Kanelli (West Roxbury, Massachusetts); John Daristotle (Bel Air, Maryland) |
| ABSTRACT | Disclosed are compositions that stabilize (e.g., thermo-stabilize) biological agents, such as mRNA. Also disclosed are methods of administering and using said compositions. |
| FILED | Tuesday, September 06, 2022 |
| APPL NO | 17/903586 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1272 (20130101) Original (OR) Class A61K 9/5123 (20130101) A61K 31/7105 (20130101) A61K 39/00 (20130101) A61K 47/26 (20130101) A61K 2039/53 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230072788 | Jones et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dean P. Jones (Decatur, Georgia); Andrew S. Neish (Atlanta, Georgia); Ken Liu (Atlanta, Georgia); Bejan Saeedi (Atlanta, Georgia) |
| ABSTRACT | This disclosure relates to uses of 5-aminovaleric acid betaine and compositions related thereto. In certain embodiments, this disclosure relates to diagnostic assays and methods of measuring and monitoring 5-aminovaleric acid betaine levels or the ratio 5-aminovaleric acid betaine to carnitine in a sample. In certain embodiments, this disclosure relates to methods of treating or preventing muscle wasting comprising administering to a subject in need thereof an effective amount of 5-aminovaleric acid betaine, prodrug, or salt thereof |
| FILED | Tuesday, September 06, 2022 |
| APPL NO | 17/903392 |
| CURRENT CPC | Fodder A23K 20/158 (20160501) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/68 (20130101) G01N 33/92 (20130101) Original (OR) Class G01N 2800/32 (20130101) G01N 2800/044 (20130101) G01N 2800/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230072954 | Asokan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | Duke University (Durham, North Carolina) |
| INVENTOR(S) | Aravind Asokan (Durham, North Carolina); Rita Meganck (Durham, North Carolina) |
| ABSTRACT | The present disclosure provides nucleic acid molecules encoding for at least two circular RNA (circRNAs), adeno-associated virus (AAV) particles including nucleic acid molecules encoding for at least two circRNAs, pharmaceutical compositions, and methods for delivering such to a subject. |
| FILED | Thursday, April 01, 2021 |
| APPL NO | 17/796874 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 2750/14143 (20130101) C12N 2750/14171 (20130101) C12N 2830/42 (20130101) C12N 2840/44 (20130101) C12N 2840/203 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230072999 | Scott et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MICROGEM INTERNATIONAL PLC (Southampton, United Kingdom) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Orion Scott (Charlottesville, Virginia); Christopher Birch (Charlottesville, Virginia); Daniel Mills (Charlottesville, Virginia); Brian Root (Charlottesville, Virginia); James Landers (Charlottesville, Virginia); Jingyi Li (Charlottesville, Virginia); Matthew Yeung (Mount Waverley, Australia); David Saul (Dunedin, Australia); David Vigil (Mount Waverley, Australia); Andrew Guy (Mount Waverley, Australia); Stan Wada (Mount Waverley, Australia); Betina De Gorordo (Mount Waverley, Australia); Steward Dodman (Mount Waverley, Australia); Tom Moran (Southampton, United Kingdom); Stuart Knowles (Mount Waverley, Australia); Fernando Dias (Mount Waverley, Australia); Rick Gardner (Mount Waverley, Australia) |
| ABSTRACT | A collection device for a biological sample to capture target compounds such as viruses or other pathogens or particles for testing from within the sample and move the captured target compound to a separate chamber for subsequent processing. The collection device can include an openable substance blister including capture particles located in a cup interior. Capture particles can attract and bind the target compounds from the sample. An extraction tube extracts any nucleic acid from the target compound for storage or subsequent amplification and testing to confirm presence of known microorganisms. The extraction tube can comprise a heat-deformable material and can be connected to a microfluidic cartridge for further processing of nucleic acid including, amplification and detection. The microfluidic cartridge includes valves and a plurality of chambers for amplification. |
| FILED | Friday, August 05, 2022 |
| APPL NO | 17/881802 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 3/502738 (20130101) Original (OR) Class B01L 3/502761 (20130101) B01L 7/52 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/18 (20130101) G01N 1/4022 (20130101) G01N 33/54326 (20130101) G01N 33/56983 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230073246 | Feldman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PHLIDELPHIA, Pennsylvania) |
| ASSIGNEE(S) | TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PHILADELPHIA, Pennsylvania) |
| INVENTOR(S) | Arthur M. Feldman (Wynnewood, Pennsylvania); Douglas G. Tilley (Bryn Mawr, Pennsylvania); Weizhong Zhu (Cockeysville, Maryland); Kamel Khalili (Bala Cynwyd, Pennsylvania); Walter J. Koch (Broomall, Pennsylvania) |
| ABSTRACT | Compositions are directed to BCL2-associated athanogene 3 (BAG3) molecules and agents which modulate expression of BAG3 molecules. Pharmaceutical composition for administration to patients, for example, patients with heart failure, comprise one or more BAG3 molecules or agents which modulate expression of BAG3. Methods of treatment and identifying candidate therapeutic agents are also provided. |
| FILED | Wednesday, October 05, 2022 |
| APPL NO | 17/938209 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6887 (20130101) G01N 33/6893 (20130101) G01N 2800/325 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230073248 | Huang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado. a body Corporate (Denver, Colorado); Angimmune LLC (Bethesda, Maryland); The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christene A. Huang (Denver, Colorado); David M. Neville, JR. (Bethesda, Maryland); Elizabeth Anne Pomfret (Aurora, Colorado); Raimon Duran-Struuck (Bala Cynwyd, Pennsylvania); Zhirui Wang (Denver, Colorado) |
| ABSTRACT | Embodiments disclosed herein relate to compositions and methods for inducing transplantation tolerance using immunomodulation agents. In certain embodiments compositions and methods disclosed herein, concern administering a composition including, but not limited to, anti-CD3 immunotoxin and administering a composition including, but not limited to, peripheral blood cells obtained from a donor of an organ, tissue or cells to be transplanted. In some embodiments, compositions and methods disclosed here can be used for modulating B- and/or T-cell-mediated immunity and/or rejection by reducing or eliminating anti-donor antibody production. Other embodiments concern modulating T-cell production in a subject preparing for, undergoing organ, tissue or cellular transplantation; or having or expected of developing GvHD for reducing the risk of, preventing or treating rejection or GvHD. In certain embodiments, combination compositions of anti-CD3 immunotoxin and peripheral blood cells from a donor are contemplated. |
| FILED | Thursday, August 18, 2022 |
| APPL NO | 17/820808 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/42 (20130101) A61K 31/52 (20130101) A61K 31/58 (20130101) A61K 31/436 (20130101) A61K 31/519 (20130101) A61K 31/573 (20130101) A61K 31/5377 (20130101) A61K 35/14 (20130101) A61K 38/13 (20130101) A61K 38/45 (20130101) A61K 39/3955 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230073324 | Lew et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Matthew Lew (St. Louis, Missouri); Tingting Wu (St. Louis, Missouri); Tianben Ding (St. Louis, Missouri) |
| ABSTRACT | Systems, devices and methods for determining an orientation and a rotational mobility of the single point emitter using a duo-spot point spread function (PSF) phase mask are disclosed. The duo-spot PSF phase mask includes at least three partitions, in which each partition includes a phase delay ramp aligned along one of two phase delay axes. Each phase delay ramp includes a gradient of phase delays. Each partition includes a subset of a total area of the phase mask and the two phase delay axes are oriented in different directions. The duo-spot PSF phase mask is configured to produce a duo-spot PSF that includes two light spots. The relative brightness of the two spots encodes an orientation and a rotational mobility of the single point emitter. |
| FILED | Tuesday, February 16, 2021 |
| APPL NO | 17/800171 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6458 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230073364 | MALIK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| INVENTOR(S) | Hafiz MALIK (Ann Arbor, Michigan); Syed IRTAZA (Ann Arbor, Michigan) |
| ABSTRACT | Traditional speaker verification systems are vulnerable to voice spoofing attacks, such as voice-replay attack, voice-cloning attack, and cloned-replay attack. To overcome these vulnerabilities, a secure automatic speaker verification system based on a novel sign modified acoustic local ternary pattern (sm-ALTP) features and asymmetric bagging-based classifier-ensemble with enhanced attack vector is presented. The proposed audio representation approach clusters the high and low frequency components in audio frames by normally distributing them against a convex function. Afterwards, the neighborhood statistics are applied to capture the user specific vocal tract information. |
| FILED | Tuesday, January 12, 2021 |
| APPL NO | 17/792283 |
| CURRENT CPC | Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 17/04 (20130101) Original (OR) Class G10L 17/06 (20130101) G10L 25/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230073449 | DALEY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| INVENTOR(S) | George Q. DALEY (Cambridge, Massachusetts); Ran JING (Boston, Massachusetts) |
| ABSTRACT | The technology described herein is directed to stromal-free methods of T cell differentiation. Also described herein are immune cells differentiated using stromal-free methods and compositions comprising such immune cells. In some embodiments, the immune cells can be genetically modified. In some embodiments, the immune cells or compositions comprising said immune cells can be administered to a patient as a cellular replacement therapy to treat a condition. |
| FILED | Friday, January 22, 2021 |
| APPL NO | 17/794747 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/5156 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230073558 | Lamba et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida); St. Jude Children's Research Hospital, Inc. (Memphis, Tennessee); University of Tennessee Research Foundation (Knoxville, Tennessee) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida); St. Jude Children's Research Hospital, Inc. (Memphis, Tennessee); University of Tennessee Research Foundation (Knoxville, Tennessee) |
| INVENTOR(S) | Jatinder Kaur Lamba (Gainesville, Florida); Stanley Pounds (Memphis, Tennessee); Abdelrahman H. Elsayed (Gainesville, Florida); Xueyuan Cao (Memphis, Tennessee) |
| ABSTRACT | Aspects of the disclosure relate to compositions and methods for predicting prognosis and classifying risk of subjects having certain cancers, for example acute myeloid leukemia (AML). In some embodiments, methods described by the disclosure comprise a step of assessing the mRNA expression of certain leukemic stem cell (LSC)-enriched genes in a subject to produce a predictive score for pediatric AML. In some embodiments, methods described by the disclosure comprise a step of assessing the mRNA expression of certain genes of pharmacological relevance for standard chemotherapy consisting of Cytarabine (also known as Ara-C), daunorubicin and etoposide in a subject to produce a predictive score for pediatric AML. |
| FILED | Tuesday, September 22, 2020 |
| APPL NO | 17/762441 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/158 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 25/10 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230073594 | MacManus et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ventria Bioscience Inc. (Junction City, Kansas); The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher MacManus (Fort Collins, Colorado); Colm Collins (Denver, Colorado); Edwin De Zoeten (Denver, Colorado) |
| ABSTRACT | Methods of inducing a regulatory T cell (Treg) phenotype and skewing naïve T cells toward a pro-regulatory phenotype are disclosed. |
| FILED | Thursday, August 25, 2022 |
| APPL NO | 17/822175 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/40 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) A61P 29/00 (20180101) A61P 37/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230073725 | Rafikov et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ruslan Rafikov (Tucson, Arizona); Olga Rafikova (Tucson, Arizona) |
| ABSTRACT | The present invention features a method comprising a metabolomic biomarker panel representing a metabolomic profile/fingerprint and methods of applying the profile to diagnose, monitor, and guide treatment for PAH. The profile comprises a unique panel of 36 metabolomic biomarkers/metabolites detected in plasma and/or urine obtained from the patient. The present invention allows for identification of patients with PAH in early-stage disease, before the condition has progressed sufficiently to produce clinical symptoms, and uniquely distinguishes PAH from pulmonary hypertension due to type 2 Diabetes Mellitus (DM) and/or left heart disease. The present invention allows for pre-screening of patients to identify PAH at the asymptomatic stage or help to minimize the time for PAH diagnosis after initial symptom onset. |
| FILED | Thursday, January 14, 2021 |
| APPL NO | 17/792902 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 25/00 (20190201) G16B 40/20 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
20230073946 — AFFINITY PEPTIDE CONJUGATED WITH ANTIOXIDANT FOR PROTECTION OF PROTEINS FROM OXIDATION
| US 20230073946 | Rafikov et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ruslan Rafikov (Tucson, Arizona); Olga Rafikova (Tucson, Arizona) |
| ABSTRACT | The present invention is a targeted peptide conjugated with an antioxidant, NO, to inhibit Akt nitration. The nitroxide peptide (NP), comprises two parts, one being the peptide part with the affinity to Akt near Tyr 350 residue (Ser-Arg-IIe-Arg-Ser; SRIRS)—and the other, a conjugated antioxidant—nitroxide (3-Carboxy-2,2,5,5-tetramethyl-3-pyrroline-1-yloxy) covalently attached to the free N-terminal amine. It can be utilized for treating pulmonary arterial hypertension (PAH) with potential application in other abnormal proliferative disorders such as cancer. The present invention features targeted selectivity for Akt nitration and does not affect Akt phosphorylation nor other physiological processes controlled by Akt signaling pathways. The present invention may also apply to other proliferative disorders including cancer or other disorders that cause or are caused by Akt nitration or protein oxidation. |
| FILED | Wednesday, January 20, 2021 |
| APPL NO | 17/794229 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 47/64 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/12 (20180101) A61P 11/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1205 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230073981 | Hoshida et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | The Board of Regents of The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Yujin Hoshida (Dallas, Texas); Naoto Fujiwara (Dallas, Texas); Amit G. Singal (Dallas, Texas); Thomas F. Baumert (Dallas, Texas) |
| ABSTRACT | Disclosures herein are directed to methods and compositions for predicting high- and low-risk liver disease in patients. Based on the results achieved from the methods and compositions disclosed herein, liver disease patients can be classified into a prognostic risk group, which enables early diagnosis and prevention of HCC and other lethal complications. Methods and compositions disclosed herein substantially improve the poor prognosis of subjects having or at risk for one or more liver diseases. |
| FILED | Friday, August 26, 2022 |
| APPL NO | 17/896944 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/68 (20130101) G01N 33/57438 (20130101) Original (OR) Class G01N 2800/085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230074115 | TREND et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cipla USA, Inc. (Warren, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Raissa TREND (Warren, New Jersey); Michael DAPPEN (Warren, New Jersey); Christopher E. HENRY (Warren, New Jersey); Adam Aaron GOLDBLUM (Warren, New Jersey); James Bradley AGGEN (Warren, New Jersey); Ricardo Filipe de Jesus Gonçalves MENDONÇA (Warren, New Jersey); João Carlos Falcão SARDINHA (Warren, New Jersey) |
| ABSTRACT | The present disclosure relates to novel methods for preparing antibacterial aminoglycoside compounds, as well as to related intermediates, and crystal forms thereof, useful in such methods. |
| FILED | Thursday, August 04, 2022 |
| APPL NO | 17/881462 |
| CURRENT CPC | General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/13 (20130101) Heterocyclic Compounds C07D 407/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230074615 | GE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); DUKE UNIVERSITY (Durham, North Carolina) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); DUKE UNIVERSITY (Durham, North Carolina) |
| INVENTOR(S) | Xin GE (Riverside, California); Tyler LOPEZ (Riverside, California); Ru-Rong JI (Durham, North Carolina) |
| ABSTRACT | Certain embodiments provide an isolated anti-matrix metalloproteinase-9 (MMP-9) antibody or fragment thereof, as well as methods of use thereof. |
| FILED | Thursday, May 21, 2020 |
| APPL NO | 17/612514 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 23/00 (20180101) Peptides C07K 16/40 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230074652 | ELMASRY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | New York Society for the Relief of the Ruptured and Crippled, maintaining the Hospital for Special S (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shady ELMASRY (New York, New York); Carl IMHAUSER (New York, New York); Peter SCULCO (New York, New York); Geoffrey WESTRICH (New York, New York); Cynthia KAHLENBERG (New York, New York) |
| ABSTRACT | Measured forces applied by a medical professional during a gap assessment can be measured. A plurality of force sensors is placed at a lateral ankle position, a medial ankle position, a lateral foot position, and/or a medial foot position, and each detects an applied force during an abduction-adduction examination. Further, a computing device receives, from each of the plurality of sensors during the abduction-adduction examination, data representing an applied force occurring during the abduction-adduction examination at respective ones of the lateral ankle position, the medial ankle position, the lateral foot position, and the medial foot position. The computing device calculates, using the received data, respective peak applied forces during the abduction-adduction examination in extension and flexion, and provides information representing a correlation of the respective peak applied forces with other information. |
| FILED | Friday, February 05, 2021 |
| APPL NO | 17/797564 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 2090/3916 (20160201) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/461 (20130101) A61F 2/4657 (20130101) Original (OR) Class A61F 2002/4633 (20130101) A61F 2002/4666 (20130101) A61F 2002/4667 (20130101) A61F 2002/4668 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230074691 | Maisel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Katharina Maisel (Bethesda, Maryland); Laura Ensign (Towson, Maryland); Justin Hanes (Baltimore, Maryland); Richard Cone (Baltimore, Maryland) |
| ABSTRACT | Hypotonic formulations of hydrogel forming polymers, preferably poloxamers, have been developed for enhanced delivery through mucosa of therapeutic, diagnostic, prophylactic or other agents, to epithelial tissues, especially those having a mucosal coating. The polymers are administered at a concentration above, at or less than their critical gelling concentration (CGC) under isotonic conditions. The hypotonicity of the formulation is adjusted so that the polymer gels at the lower concentration. A Poloxamer gel administered into the vagina or colorectum at its CGC will form a “plug” of gel in the lumen. |
| FILED | Monday, August 29, 2022 |
| APPL NO | 17/898318 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 8/90 (20130101) A61K 9/06 (20130101) A61K 9/08 (20130101) A61K 9/0031 (20130101) Original (OR) Class A61K 9/0034 (20130101) A61K 9/5146 (20130101) A61K 9/5153 (20130101) A61K 31/09 (20130101) A61K 31/52 (20130101) A61K 31/352 (20130101) A61K 31/365 (20130101) A61K 31/675 (20130101) A61K 47/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230074730 | DEKLEVA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Brian DEKLEVA (Pittsburgh, Pennsylvania); Jennifer Lynn COLLINGER (Pittsburgh, Pennsylvania) |
| ABSTRACT | Disclosed herein are methods and systems for transient-based decoding of neural signals. In one aspect, a device such as a brain-computer interface (BCI), includes at least one processor configured to receive a plurality of neural signals from a subject. The at least one processor can detect, from the plurality of neural signals, first neural activity unique to a first defined temporal window corresponding to an onset phase of an intended action of the subject. The at least one processor can detect, from the plurality of neural signals, second neural activity unique to a second defined temporal window, occurring after the first temporal window and corresponding to an offset phase of the intended action. The at least one processor can generate at least one output indicative of the intended action, responsive to detecting at least one of the first neural activity or the second neural activity. |
| FILED | Wednesday, September 07, 2022 |
| APPL NO | 17/939893 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/372 (20210101) Electric Digital Data Processing G06F 3/015 (20130101) Original (OR) Class G06F 3/0484 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230074840 | ZHANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Feng ZHANG (Cambridge, Massachusetts); Bernd ZETSCHE (Cambridge, Massachusetts); Johnathan S. GOOTENBERG (Cambridge, Massachusetts); Omar O. ABUDAYYEH (Cambridge, Massachusetts); Ian SLAYMAKER (Cambridge, Massachusetts) |
| ABSTRACT | The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA-targeting systems comprising a novel DNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA. Methods for making and using and uses of such systems, methods, and compositions and products from such methods and uses are also disclosed and claimed. |
| FILED | Friday, December 17, 2021 |
| APPL NO | 17/554314 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/113 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6816 (20130101) C12Q 1/6832 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230074892 | Turner et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul Turner (New Haven, Connecticut); Alita Burmeister (Hamden, Connecticut); Benjamin Chan (Salt Lake City, Utah); Kaitlyn Kortright (New Haven, Connecticut); John Wertz (Cheshire, Connecticut) |
| ABSTRACT | The present invention includes compositions and methods for increasing antibiotic sensitivity and/or decreasing virulence in bacteria. |
| FILED | Thursday, May 07, 2020 |
| APPL NO | 17/609225 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/76 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230074894 | Agbandje-McKenna et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| INVENTOR(S) | Mavis Agbandje-McKenna (Gainesville, Florida); Mario Mietzsch (Gainesville, Florida) |
| ABSTRACT | This disclosure relates to variant AAVrh.10 and AAV3 particles engineered to escape host neutralizing antibodies but retain or improve transduction efficiency, and their use as gene delivery vehicles. |
| FILED | Wednesday, October 12, 2022 |
| APPL NO | 18/045873 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2015/8518 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230075095 | KING et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Neil P. KING (Seattle, Washington); Carl Walkey (Seattle, Washington); Jing Yang Wang (Seattle, Washington); Brooke Fiala (Seattle, Washington); David Veesler (Seattle, Washington); Alexandra C. Walls (Seattle, Washington); Una Nattermann (Seattle, Washington) |
| ABSTRACT | Polypeptides are disclosed herein having significantly improved secretion ability from eukaryotic cells, together with fusion proteins, nanoparticles, and uses thereof, and methods for designing such polypeptides. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/760180 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) Original (OR) Class C07K 2319/03 (20130101) C07K 2319/35 (20130101) C07K 2319/40 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/50 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230075234 | Bau et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Haim H. Bau (Swarthmore, Pennsylvania); Michael G. Mauk (Philadelphia, Pennsylvania); Ruijie Li (Wexford, Pennsylvania) |
| ABSTRACT | An exothermic composite, comprising: a reactive material (RM) that undergoes an exothermic reaction upon contact with an oxidizer, and a phase-changing thermal storage material (PCM) having a phase change temperature, wherein (1) RM and PCM are intermixed with one another or (2) one of RM and PCM is interpenetrated with the other. Devices, comprising (1) a sample container that defines a sample volume therein or (2) a receptacle configured to accept a sample container defining a sample volume therein, and the device configured such that the sample container is in thermal communication with a composite according to the present disclosure. Also provided are related methods. |
| FILED | Friday, May 06, 2022 |
| APPL NO | 17/738480 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50851 (20130101) Original (OR) Class B01L 7/52 (20130101) B01L 2300/0627 (20130101) B01L 2300/1805 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/701 (20130101) C12Q 1/6844 (20130101) Collection, Production or Use of Heat Not Otherwise Provided for F24V 30/00 (20180501) Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 20/0056 (20130101) F28D 2020/006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230075521 | Hayward et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Jupiter Neurosciences, Inc. (Jupiter, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marshall A. Hayward (Bridgewater, New Jersey); Christopher J. Kemper (Lawrenceville, New Jersey) |
| ABSTRACT | Methods of enhancing the bioavailability of resveratrol, and for the treatment of at least one neuroinflammatory disorder in a subject, include orally administering to the subject a resveratrol solubulization product formulation consisting of: resveratrol; an emulsifying agent mixture of polysorbate 80 and polysorbate 20; at least one medium-chain triglyceride (MCT); and tocopherol or mixed tocopherols, or an oral pharmaceutical composition containing same. In the methods, the formulation is orally administered to the human subject under fasting conditions. Upon oral administration to a human subject under fasting conditions, the resveratrol solubulization product formulation or oral pharmaceutical composition containing same provides at least one of the following pharmacokinetic parameters: a. AUC(0-t) of at least about 500 h*ng/mL; b. AUC(0-infin.) of no more than about 2100 h*ng/mL; and c. Cmax of at least about 220 ng/ml, wherein t is between about 1 and about 24 hours. |
| FILED | Friday, August 19, 2022 |
| APPL NO | 17/891662 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 31/05 (20130101) Original (OR) Class A61K 47/14 (20130101) A61K 47/22 (20130101) A61K 47/26 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/00 (20180101) A61P 25/00 (20180101) A61P 25/14 (20180101) A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230075527 | BAROUCH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Janssen Pharmaceuticals, Inc (Titusville, New Jersey); Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dan H. BAROUCH (Boston, Massachusetts); Johannes Petrus Maria LANGEDIJK (Amsterdam, Netherlands); Lucy RUTTEN (Rijnsburg, Netherlands); Mark Johannes Gerardus BAKKERS (Haarsteeg, Netherlands); Rinke BOS (Degstgeest, Netherlands); Frank WEGMANN (Leiden, Netherlands); David Adrianus Theodorus Maria ZUIJDGEEST (Den Haag, Netherlands); An VANDEBOSCH (Herentals, Belgium); Mathieu Claude Michel LE GARS (Antwerp, Belgium); Jerald C. SADOFF (Washington, District of Columbia) |
| ABSTRACT | The invention relates to immunogenic compositions and vaccines containing a coronavirus (e.g., Wuhan coronavirus (2019-nCoV; also referred to as SARS-CoV-2)) protein or a polynucleotide encoding a coronavirus (e.g., Wuhan coronavirus (2019-nCoV; SARS-CoV-2)) protein and uses thereof. The invention also provides methods of treating and/or preventing a coronavirus (e.g., Wuhan coronavirus (2019-nCoV; SARS-CoV-2)) infection by administering an immunogenic composition or vaccine to a subject (e.g., a human). The invention also provides methods of detecting and/or monitoring a protective anti-coronavirus (e.g., Wuhan coronavirus (2019-nCoV; SARS-CoV-2)) antibody response (e.g., anti-coronavirus antibody response, e.g., anti-2019-nCoV antibody response, e.g., anti-Spike antibody response, e.g., anti-Spike neutralizing antibody response). The present invention relates to isolated nucleic and/or recombinant nucleic acid encoding a coronavirus S protein, in particular a SARS-CoV-2 S protein, and to the coronavirus S proteins, as well as to the use of the nucleic acids and/or proteins thereof in vaccines. |
| FILED | Saturday, January 30, 2021 |
| APPL NO | 17/759803 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/215 (20130101) Original (OR) Class A61K 2039/53 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230075547 | Clarke et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | OXFORD UNIVERSITY INNOVATION LIMITED (Oxford, United Kingdom); Government of the USA, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kieran Clarke (Oxford, United Kingdom); Richard Lewis Veech (Rockville, Maryland) |
| ABSTRACT | The subject disclosure provides compositions for reducing serum cholesterol and/or triglyceride levels in subjects. These compositions can comprise racemic β-hydroxybutyrate or D-β-hydroxybutyrate, optionally in the acid form, physiologically compatible salts of racemic β-hydroxybutyrate or D-β-hydroxybutyrate, esters of D-β-hydroxybutyrate, oligomers of D-β-hydroxybutyrate containing from 2 to 20 or more monomeric units in either linear or cyclic form, racemic 1,3 butandiol or R-1,3 butandiol alone and can be, optionally, administered in conjunction with a low fat diet to a subject. Alternatively, compositions comprising racemic β-hydroxybutyrate or D-β-hydroxybutyrate, optionally in the acid form, physiologically compatible salts of racemic β-hydroxybutyrate or D-β-hydroxybutyrate, esters of D-β-hydroxybutyrate, oligomers of D-β-hydroxybutyrate containing from 2 to 20 or more monomeric units in either linear or cyclic form, racemic 1,3 butandiol, R-1,3 butandiol or combinations thereof can be formulated as nutritional supplements (also referred to as nutritional compositions) or incorporated into therapeutic compositions containing a) anti-hypertensive agents; b) anti-inflammatory agents; c) glucose lowering agents; or d) anti-lipemic agents) which are administered to a subject, optionally in combination with a low fat diet, in order to cause a reduction or lowering of: serum cholesterol levels; triglyceride levels; serum glucose levels, serum homocysteine levels, inflammatory proteins (e.g., C reactive protein) and/or hypertension in treated subjects. Alternatively, compositions disclosed herein can be administered alone, or in combination with other therapeutic agents to prevent or reverse vascular disease. |
| FILED | Monday, April 25, 2022 |
| APPL NO | 17/728600 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 31/19 (20130101) A61K 31/22 (20130101) Original (OR) Class A61K 31/047 (20130101) A61K 31/365 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/06 (20180101) A61P 3/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230075584 | SLUSHER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | BARBARA S. SLUSHER (KINGSVILLE, Maryland); RANA RAIS (OWINGS MILLS, Maryland) |
| ABSTRACT | The presently disclosed subject matter provides methods for treating and diagnosing neurological diseases or disorders using intranasal administration of glutamate carboxypeptidase II (GCP-II) inhibitors in a subject. Methods for imaging GCP-II in a subject, including imaging of the brain and/or peripheral nervous system, also are provided. |
| FILED | Thursday, May 05, 2022 |
| APPL NO | 17/737229 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0043 (20130101) Original (OR) Class A61K 31/27 (20130101) A61K 31/194 (20130101) A61K 31/198 (20130101) A61K 31/662 (20130101) A61K 49/0052 (20130101) A61K 51/04 (20130101) A61K 51/0489 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230075623 | Cima et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael J. Cima (Winchester, Massachusetts); Khalil Basil Ramadi (Brookline, Massachusetts); Erin Byrne Rousseau (Clifton, New York); Max Joseph Cotler (Somerville, Massachusetts) |
| ABSTRACT | A medical probe for guided insertion into soft tissue, such as the brain, is disclosed. The medical probe may include a flexible, elongated body having a proximal end portion and an opposed distal end portion. The elongated body has a length of at least 1 cm and an outer diameter of 80 μm or less. The distal end portion may comprise a beveled tip such that the distal end portion of the medical probe can be steered independently to a target site in the soft tissue. |
| FILED | Monday, November 14, 2022 |
| APPL NO | 17/986647 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/3403 (20130101) A61B 17/3417 (20130101) A61B 34/20 (20160201) Original (OR) Class A61B 90/10 (20160201) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/158 (20130101) A61M 2025/0042 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230075630 | Kim et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland); University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Deok-Ho Kim (Baltimore, Maryland); Changho Chun (Seattle, Washington); Alexander Smith (Seattle, Washington); Minjae Do (Seoul, South Korea) |
| ABSTRACT | Provided herein, inter alia, are compositions and methods comprising glial-derived extracellular vesicles for the prevention and treatment of neuropathies. In aspects, the glial-derived extracellular vesicles may include one or more of the following miRNA, an adeno-associated virus (AAV), siRNA, vRNA, mRNA, lncRNA, DNA, tetraspanins, amino acids, metabolites, signaling proteins, chaperones, cytoskeletal proteins, enzymes, or combinations thereof. |
| FILED | Friday, October 16, 2020 |
| APPL NO | 17/769705 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7105 (20130101) A61K 35/30 (20130101) Original (OR) Class A61K 35/76 (20130101) A61K 38/185 (20130101) A61K 38/1709 (20130101) A61K 47/6911 (20170801) A61K 48/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0619 (20130101) C12N 5/0622 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230075997 | Valdes et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Dartmouth College (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pablo Valdes (Phoenix, Arizona); Frederic Leblond (Montreal, Canada); Keith D. Paulsen (Hanover, New Hampshire); Brian Campbell Wilson (Toronto, Canada); David W. Roberts (Lyme, New Hampshire); Michael Jermyn (Longueuil, Canada) |
| ABSTRACT | An imaging system, such as a surgical microscope, laparoscope, or endoscope or integrated with these devices, includes an illuminator providing patterned white light and/or fluorescent stimulus light. The system receives and images light hyperspectrally, in embodiments using a hyperspectral imaging array, and/or using narrowband tunable filters for passing filtered received light to an imager. Embodiments may construct a 3-D surface model from stereo images, and will estimate optical properties of the target using images taken in patterned light or using other approximations obtained from white light exposures. Hyperspectral images taken under stimulus light are displayed as fluorescent images, and corrected for optical properties of tissue to provide quantitative maps of fluorophore concentration. Spectral information from hyperspectral images is processed to provide depth of fluorophore below the tissue surface. Quantitative images of fluorescence at depth are also prepared. The images are displayed to a surgeon for use in surgery. |
| FILED | Thursday, October 06, 2022 |
| APPL NO | 17/961480 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/05 (20130101) A61B 1/07 (20130101) A61B 1/00009 (20130101) A61B 1/042 (20130101) A61B 1/043 (20130101) A61B 1/000094 (20220201) A61B 1/00165 (20130101) A61B 1/00193 (20130101) A61B 1/00194 (20220201) A61B 1/0646 (20130101) A61B 1/0669 (20130101) A61B 1/0684 (20130101) A61B 1/3132 (20130101) A61B 5/055 (20130101) A61B 5/0071 (20130101) A61B 5/0077 (20130101) A61B 5/1459 (20130101) A61B 5/1495 (20130101) A61B 5/7264 (20130101) A61B 5/14546 (20130101) A61B 5/14553 (20130101) A61B 5/14556 (20130101) Original (OR) Class Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/0229 (20130101) G01J 3/1256 (20130101) G01J 3/2823 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230076027 | ZANG |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Albert Einstein College of Medicine (Bronx, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xingxing ZANG (New York, New York) |
| ABSTRACT | Provided are methods of treating an autoimmune disease in a subject, or of suppressing transplant rejection in a subject, or of treating a cancer in a subject, as well as compositions therefor. |
| FILED | Thursday, September 15, 2022 |
| APPL NO | 17/932387 |
| CURRENT CPC | Peptides C07K 16/2827 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/24 (20130101) C07K 2319/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230076063 | VALAFAR et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | San Diego State University (SDSU )Foundation, dba San Diego State University Research Foundation (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Faramarz VALAFAR (San Diego, California); Samuel MODLIN (San Diego, California); Derek CONKLE-GUTIERREZ (San Diego, California) |
| ABSTRACT | In alternative embodiments, provided are products of manufacture and kits, and methods, for treating or ameliorating a Mycobacterium tuberculosis (TB) or a Mycobacterium africanum infection. In alternative embodiments, provided are products of manufacture and kits, and methods, that comprise or comprise use of DNA methylation inhibitory molecules for treating or ameliorating a Mycobacterium tuberculosis (TB) infection. In alternative embodiments, provided are methods and device for classifying drug-resistance phenotype, or diagnosing Multi-drug resistant Tuberculosis (MDR-TB), eXtensively Drug Resistant phenotype (XDR) tuberculosis, or for clinical decision support. In alternative embodiments, provided are kits for or treating or diagnosing drug resistance of, prognosing, or assisting in clinical decision making for a Mycobacterium tuberculosis (TB) or the Mycobacterium africanum infection. |
| FILED | Friday, December 18, 2020 |
| APPL NO | 17/787114 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/12 (20130101) C12N 2310/14 (20130101) C12N 2310/141 (20130101) C12N 2310/531 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) C12Q 1/6869 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230076067 | Szeto et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York); University of Florida Research Foundation (Gainesville, Florida) |
| ASSIGNEE(S) | Cornell University (Ithaca, New York); University of Florida Research Foundation (Gainesville, Florida) |
| INVENTOR(S) | Hazel H. Szeto (New York, New York); Scott Kline Powers (Gainesville, Florida) |
| ABSTRACT | The present disclosure provides methods and compositions for preventing or treating MV-induced or disuse-induced skeletal muscle infirmities in a mammalian subject. The methods further include administering to the subject an effective amount of an aromatic-cationic peptide. |
| FILED | Friday, February 25, 2022 |
| APPL NO | 17/680778 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/06 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/00 (20180101) A61P 39/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230076403 | Steinmetz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicole F. Steinmetz (San Diego, California); Frank Alexander Veliz (Cleveland, Ohio); Brylee David B. Tiu (Cleveland, Ohio) |
| ABSTRACT | A nanoparticle construct includes a plurality of plant virus or virus-like particles electrostatically coupled to a plurality of nanoparticles having a different surface charge than the plant virus or virus-like particles. The nanoparticle construct upon delivery to a subject can provide a sustained release of the plant virus or virus-like particles and/or nanoparticles to a cell or tissue of the subject. |
| FILED | Tuesday, September 06, 2022 |
| APPL NO | 17/903286 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) Original (OR) Class A61K 39/39 (20130101) A61K 39/385 (20130101) A61K 47/6901 (20170801) A61K 2039/585 (20130101) A61K 2039/622 (20130101) A61K 2039/645 (20130101) A61K 2039/5258 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230076515 | Kagan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Children's Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan C. Kagan (Brookline, Massachusetts); Dania Zhivaki (Boston, Massachusetts) |
| ABSTRACT | The present application is related to cancer immunotherapy, e.g. stimulation of T cell mediated anti-tumor therapy. Accordingly, described herein are methods of inducing or enhancing an adaptive immune response to a cancer in a subject and methods of treating cancer in a subject. In some embodiments, the methods hyperactivate dendritic cells (DCs), which induce T helper type I (TH1) and cytotoxic T lymphocyte (CTL) responses in the absence of TH2 immunity. |
| FILED | Wednesday, November 18, 2020 |
| APPL NO | 17/777659 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) Original (OR) Class A61K 39/39 (20130101) A61K 2039/55572 (20130101) A61K 2039/55577 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230076635 | AN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California) |
| INVENTOR(S) | Dong Sung AN (LOS ANGELES, California); Saki SHIMIZU (BERKELEY, California) |
| ABSTRACT | A potent short hairpin RNA (shRNA734) directed to human Hypoxanthine Guanine Phosphoribosyltransferase (HPRT) improves the rate of gene-modified stem cell engraftment by a conditioning and in vivo selection strategy to confer resistance to a clinically available guanine analog antimetabolite, 6TG, for efficient positive selection of gene-modified stem cells. Uses for polynucleotides comprising the shRNA734 include methods for knocking down HPRT in a cell, for conferring resistance to a guanine analog antimetabolite in a cell, for producing selectable genetically modified cells, for selecting cells genetically modified with a gene of interest from a plurality of cells, for removing cells genetically modified with a gene of interest from a plurality of cells, and for treating a subject infected with HIV. |
| FILED | Friday, June 03, 2022 |
| APPL NO | 17/805344 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) A61K 45/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0081 (20130101) C12N 15/86 (20130101) C12N 15/1137 (20130101) Original (OR) Class C12N 2310/531 (20130101) C12N 2740/15043 (20130101) Enzymes C12Y 204/02008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230076792 | LI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yuanpei LI (Oakland, California); Hao WU (Oakland, California); Tzu-yin LIN (Oakland, California) |
| ABSTRACT | The present invention provides a compound of Formula (I) as defined herein. The present invention also provides a nanoparticle comprising a plurality of the conjugates of the present invention, and methods of using the nanoparticles for drug delivery, treating a disease, and methods of imaging. |
| FILED | Wednesday, December 16, 2020 |
| APPL NO | 17/785765 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/60 (20170801) A61K 47/542 (20170801) A61K 47/6935 (20170801) Original (OR) Class A61K 49/0034 (20130101) A61K 49/0054 (20130101) A61K 49/085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230076809 | Chaudhary et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Iowa Research Foundation (Iowa City, Iowa) |
| ASSIGNEE(S) | University of Iowa Research Foundation (Iowa City, Iowa) |
| INVENTOR(S) | Muhammad F. A. Chaudhary (Iowa City, Iowa); Joseph M. Reinhardt (Iowa City, Iowa); Sarah E. Gerard (Iowa City, Iowa); Eric A. Hoffman (Iowa City, Iowa) |
| ABSTRACT | A machine implemented method includes acquiring at a processor a first image of a patent by performing a computed tomography (CT) scan of a patient and applying at the processor a generative neural network model to the first image of the patient to generate a second image of the patient. The method may further include performing, at the processor, an analysis using the first image and the second image. The first image may be a first pulmonary image and the second image may be a second pulmonary image. The first pulmonary image may show lungs at a first volume and the second pulmonary image may show the lungs at a second volume, the first volume different from the second volume. The first pulmonary image may be a scan of the lungs at expiration and the second pulmonary image may be an inspiratory image of the lungs. |
| FILED | Friday, August 19, 2022 |
| APPL NO | 17/891222 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 6/032 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 7/0014 (20130101) G06T 2207/30061 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230076975 | ANSLYN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric V. ANSLYN (Austin, Texas); Edward MARCOTTE (Austin, Texas); Cecil J. HOWARD, II (Austin, Texas); Jagannath SWAMINATHAN (Austin, Texas); Angela M. BARDO (Austin, Texas); Caroline M. HINSON (Austin, Texas); Brendan FLOYD (Austin, Texas); Le ZHANG (Austin, Texas) |
| ABSTRACT | Described herein are methods for selectively cleaving the C-terminal amino acid of a peptide or protein. The methods described herein may be applicable for, for example, single-molecule peptide or protein sequencing. |
| FILED | Thursday, August 18, 2022 |
| APPL NO | 17/820646 |
| CURRENT CPC | Peptides C07K 1/13 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 11/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/58 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230076977 | KHURANA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania); University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh,, Pennsylvania) |
| ASSIGNEE(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania); University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Tejvir S. KHURANA (Narberth, Pennsylvania); Donna M. HURYN (Allentown, New Jersey) |
| ABSTRACT | The present invention provides methods for increasing expression of utrophin in a subject in need thereof, the method comprising administering to the subject a pharmaceutical composition comprising a post-transcriptionally utrophin upregulator compound. The present invention also provides methods for treating a subject having a muscular dystrophy. This invention further provides methods for high-throughput screening for a post-transcriptional utrophin upregulator compound. |
| FILED | Thursday, January 14, 2021 |
| APPL NO | 17/792707 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/18 (20130101) A61K 31/44 (20130101) A61K 31/165 (20130101) Original (OR) Class A61K 31/343 (20130101) A61K 31/423 (20130101) A61K 31/519 (20130101) A61K 31/4045 (20130101) A61K 31/4184 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230077104 | Oates et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERAN AFFAIRS (Washington, District of Columbia); MUSC FOUNDATION FOR RESEARCH DEVELOPMENT D/B/A ZUCKER INSTITUTE FOR INNOVATION (Charleston, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Oates (Charleston, South Carolina); Joy Jones Buie (Charleston, South Carolina) |
| ABSTRACT | The present invention provides compositions and methods for increasing nitric oxide production for treating or preventing a chronic inflammatory autoimmune disease or disorder. |
| FILED | Friday, February 19, 2021 |
| APPL NO | 17/800207 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/04 (20130101) A61K 31/275 (20130101) A61K 31/345 (20130101) A61K 31/519 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230077280 | Mitch et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Baylor College of Medicine (Houston, Texas); Tvardi Therapeutics, Inc. (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William E. Mitch (Houston, Texas); Liping Zhang (Houston, Texas); David J. Tweardy (Houston, Texas); Imran Alibhai (Sugar Land, Texas); Sofia de Achaval (Missouri City, Texas) |
| ABSTRACT | Embodiments of the disclosure encompass methods of treating insulin resistance in an individual in need thereof by administering one or more STAT3 inhibitors to the individual. In specific aspects, the methods allow for reversing insulin resistance in individuals. The STAT3 inhibitor may be one or more particular small molecules encompassed herein. |
| FILED | Thursday, December 03, 2020 |
| APPL NO | 17/781349 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/18 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20230070099 | Johnson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Phillip I. Johnson (Ellicott City, Maryland); Jonathan P. Jones (Hanover, Maryland) |
| ABSTRACT | A distillation column including a plurality of alternating plates and spacers stacked in a z-direction is provided. The plates include a respective liquid channeling network on a top surface thereof, a respective vapor opening, and a respective descending ramp. The respective descending ramps abut a respective liquid feed location of the plate immediately below to form a continuous liquid channeling network. The respective vapor openings of adjacent plates are located on opposite sides of the distillation column and form a continuous S-shaped vapor channel defined by the plurality of alternating plates and spacers, and the respective vapor openings. Systems including such distillation columns and processes of distilling a fluid mixture are also provided. |
| FILED | Friday, September 03, 2021 |
| APPL NO | 17/465971 |
| CURRENT CPC | Separation B01D 3/02 (20130101) B01D 5/006 (20130101) B01D 5/009 (20130101) B01D 5/0015 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230070364 | THOSTENSON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF DELAWARE (NEWARK, Delaware) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ERIK THOSTENSON (NEWARK, Delaware); THOMAS SCHUMACHER (PORTLAND, Oregon) |
| ABSTRACT | Processes for depositing functionalized nanoparticles upon a non-conductive substrate are disclosed herein. The processes may include the step of aerosolizing one or more particles into suspension within a gas, each of the one or more particles comprising functionalized nanoparticles having an electric charge. The processes may include the step the step of attracting the one or more particles onto a non-conductive substrate by a static electric charge opposite of the electric charge, wherein at least portions of the non-conductive substrate are having the static electric charge. The processes may include the step of depositing the functionalized nanoparticles onto the non-conductive substrate |
| FILED | Wednesday, November 09, 2022 |
| APPL NO | 17/983818 |
| CURRENT CPC | Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials C03C 25/44 (20130101) Original (OR) Class Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/4419 (20130101) C09D 7/61 (20180101) Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 13/02 (20130101) C25D 13/12 (20130101) C25D 13/22 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/254 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230070399 | Walter et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of The University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nils Walter (Ann Arbor, Michigan); Alexander Johnson-Buck (Brighton, Massachusetts); Mario Blanco (Pasadena, California); Arlie Rinaldi (Pasadena, California) |
| ABSTRACT | Provided herein is technology relating to detecting and identifying nucleic acids and particularly, but not exclusively, to compositions, methods, kits, and systems for detecting, identifying, and quantifying target nucleic acids with high confidence at single-molecule resolution. |
| FILED | Tuesday, September 06, 2022 |
| APPL NO | 17/929809 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6816 (20130101) C12Q 1/6837 (20130101) Original (OR) Class C12Q 1/6886 (20130101) C12Q 2600/178 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230070465 | Mi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zetian Mi (Ann Arbor, Michigan); Ping Wang (Ann Arbor, Michigan); Ding Wang (Ann Arbor, Michigan) |
| ABSTRACT | A method of fabricating a heterostructure includes providing a substrate, and implementing a non-sputtered, epitaxial growth procedure at a growth temperature to form a wurtzite structure supported by the substrate. The wurtzite structure includes an alloy of gallium nitride. The non-sputtered, epitaxial growth procedure is configured to incorporate a group IIIB element into the alloy. The wurtzite structure exhibits a breakdown field strength greater than a ferroelectric coercive field strength of the wurtzite structure. |
| FILED | Thursday, September 08, 2022 |
| APPL NO | 17/940759 |
| CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 25/10 (20130101) C30B 25/18 (20130101) C30B 29/406 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/02192 (20130101) Original (OR) Class H01L 21/02194 (20130101) H01L 27/1159 (20130101) H01L 29/516 (20130101) H01L 29/0607 (20130101) H01L 29/2003 (20130101) H01L 29/6684 (20130101) H01L 29/7786 (20130101) H01L 29/40111 (20190801) H01L 29/66462 (20130101) H01L 29/78391 (20140902) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230070932 | Merrett |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States as Represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | Government of the United States as Represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| INVENTOR(S) | Joseph Neil Merrett (Decherd, Tennessee) |
| ABSTRACT | A semiconductor structure configured to implement an optically controlled field effect transistor (FET). In one embodiment, a normally-off, optically controlled FET is realized as a semiconductor structure comprising various regions configured to implement a voltage controlled, normally on, high voltage FET region having integrated thereon a photoconductive region configured to reduce a gate-to-source voltage of the FET in response to light incident upon the photoconductive region so as to turn the FET on. |
| FILED | Friday, September 09, 2022 |
| APPL NO | 17/931067 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/1136 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230071046 | Pestourie et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | International Business Machines Corporation (Armonk, New York); MIT MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Raphaël Pestourie (Cambridge, Massachusetts); Youssef Mroueh (New York, New York); Payel Das (Yorktown Heights, New York); Steven Glenn Johnson (Arlington, Massachusetts) |
| ABSTRACT | Embodiments of the present invention provide computer-implemented methods, computer program products and computer systems. Embodiments of the present invention can, in response to receiving parameters associated with a problem, train at least one generated data model to evaluate an estimation of a solution for the problem. Embodiments of the present invention can then generate an uncertainty quantification measure associated with an estimation of error for the at least one generated data model. Embodiments of the present invention can then filter data based on the generated uncertainty quantification measure associated with the at least one generated data model and automatically retrain the at least one generated data model using the remaining data from the filtered data |
| FILED | Wednesday, August 18, 2021 |
| APPL NO | 17/405318 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 5/04 (20130101) G06N 20/00 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230071162 | Connolly et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Quantum Diamond Technologies Inc. (Somerville, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Colin B. Connolly (Cambridge, Massachusetts); Jeffrey D. Randall (Westford, Massachusetts); John C. Pena (Cambridge, Massachusetts) |
| ABSTRACT | The present application discloses methods and apparatus for detecting a complex including an analyte that include contacting a sample in a solution with a population of functionalized beads of a first type, which are magnetic functionalized beads and are functionalized to include a first moiety that associates with an analyte under suitable conditions, contacting the sample solution with a population of functionalized beads of a second type, which are functionalized to include a second moiety that associates with the analyte under suitable conditions, contact resulting in formation of a complex including one of the first type of functionalized bead, the analyte, and one of the second type of functionalized bead, and detecting the complex including the analyte by detecting magnetic fields produced by the magnetic functionalized bead and by detecting the functionalized bead of the second type associated with the analyte in the complex. |
| FILED | Monday, November 07, 2022 |
| APPL NO | 17/981658 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 24/10 (20130101) G01N 27/745 (20130101) G01N 33/536 (20130101) G01N 33/553 (20130101) G01N 33/54326 (20130101) Original (OR) Class Measuring Electric Variables; Measuring Magnetic Variables G01R 33/26 (20130101) G01R 33/323 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230071678 | Dombrowski et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel M. Dombrowski (Fairborn, Ohio); Robert A. Bettinger (Oakwood, Ohio) |
| ABSTRACT | The present invention relates to a resident space object orbit determination system comprising a high efficiency module for determining a resident space object's orbit and a highly efficient method for determining same. Applicants developed a method and system to determine the orbits of residence space objects including resident space objects that do not reflect energy that is directed at them and/or may be coated to minimize the ability to accurately see such resident space objects. Thus, a method, a module and a system for making such determinations that can easily and inexpensively be added to an early warning reentry system is provided. |
| FILED | Tuesday, September 07, 2021 |
| APPL NO | 17/467548 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/62 (20130101) B64G 1/105 (20130101) B64G 1/242 (20130101) Original (OR) Class B64G 2001/1064 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230071730 | Imani |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mohsen Imani (Irvine, California) |
| ABSTRACT | An artificial intelligence framework is disclosed having a spiking neural network configured to extract low-level features from event-based spiking data and provide the low-level features as a spiking neural network output signal. Further included is a hyperdimensional computing block that is configured to map the spiking neural network output into high-dimensional space and classify data from the abstract information. |
| FILED | Thursday, August 25, 2022 |
| APPL NO | 17/895171 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/084 (20130101) Original (OR) Class G06N 5/022 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230072191 | Skadron et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin Skadron (Charlottesville, Virginia); Marzieh Lenjani (Champaign, Illinois); Abdolrasoul Sharift (Charlottesville, Virginia); Lingxi Wu (Charlottesville, Virginia) |
| ABSTRACT | Apparatus includes a plurality of memory cells (e.g., a dynamic random access memory (DRAM)) addressable as rows and columns and a plurality of matching circuits configured to be coupled to respective bit lines associated with the columns A control circuit is configured to store respective reference sequences (e.g., binary-encoded k-mer patterns) in respective ones of the columns, to sequentially provide rows of bits stored in the memory cells and bits of a query to the matching circuits, and to identify one of the reference sequences as corresponding to the query responsive to comparisons by the matching circuits. |
| FILED | Tuesday, August 31, 2021 |
| APPL NO | 17/462836 |
| CURRENT CPC | Static Stores G11C 7/12 (20130101) G11C 7/106 (20130101) G11C 7/1087 (20130101) Original (OR) Class Pulse Technique H03K 19/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230073023 | Bartolomeo |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rolls-Royce Corporation (Indianapolis, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark E. Bartolomeo (Indianapolis, Indiana) |
| ABSTRACT | In some examples, a cone clutch assembly includes an inner cone member rotationally coupled to a first shaft, the inner cone member defining a first friction surface; and an outer cone member rotationally coupled to a second shaft, the outer cone member defining a second friction surface opposing the first friction surface. The inner cone member and outer cone member may be selectively engaged and disengaged from another. The inner cone member and/or the outer cone member may include a first metallic layer and a second metallic layer separated by an open structure core. The open structure core is configured to allow flow of a fluid between the first metallic layer and the second metallic layer to remove heat from the at least one of the inner cone member or the outer cone member. |
| FILED | Friday, September 03, 2021 |
| APPL NO | 17/446893 |
| CURRENT CPC | Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/32 (20130101) Couplings for Transmitting Rotation; Clutches; Brakes F16D 13/26 (20130101) Original (OR) Class F16D 13/66 (20130101) F16D 13/72 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230073209 | Bathe et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark Bathe (Cambridge, Massachusetts); Sakul Ratanalert (Baltimore, Maryland); Remi Veneziano (Manassas, Virginia); James Banal (Cambridge, Massachusetts); Tyson Shepherd (Louisville, Colorado) |
| ABSTRACT | Methods for controlled segregation of blocks of information encoded in the sequence of a biopolymer, such as nucleic acids and polypeptides, with rapid retrieval based on multiply addressing nanostructured data have been developed. In some embodiments, sequence controlled polymer memory objects include data-encoded biopolymers of any length or form encapsulated by natural or synthetic polymers and including one or more address tags. The sequence address labels are used to associate or select memory objects for sequencing read-out, enabling organization and access of distinct memory objects or subsets of memory objects using Boolean logic. In some embodiments, a memory object is a single-stranded nucleic acid scaffold strand encoding bit stream information that is folded into a nucleic acid nanostructure of arbitrary geometry, including one or more sequence address labels. Methods for controlled degradation of biopolymer-encoded blocks of information in the memory objects are also developed. |
| FILED | Friday, October 28, 2022 |
| APPL NO | 18/050733 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 2563/149 (20130101) C12Q 2563/185 (20130101) Electric Digital Data Processing G06F 12/0646 (20130101) G06F 2212/251 (20130101) Computer Systems Based on Specific Computational Models G06N 3/123 (20130101) Original (OR) Class Static Stores G11C 13/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230073224 | Schuster et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David I. Schuster (Chicago, Illinois); Helin Zhang (Chicago, Illinois) |
| ABSTRACT | Methods for initializing a qubit into a pure state, reading the qubit, and arbitrarily rotating the qubit into any quantum state complete in times shorter than the qubit's typical dephasing and relaxation times. These methods provide universal single-qubit control and may be used to implement quantum gates with high fidelity. The methods may be implemented with superconducting qubits, such as heavy fluxonium, and do not rely on a three-dimensional cavity for suppressing spontaneous emission. Therefore, the methods may be implemented using smaller two-dimensional architectures commonly used for superconducting circuits. The methods also work with low-frequency qubits, i.e., qubits for which the energy spacing between the two quantum-computational states is less than the mean thermal energy of a surrounding bath. This reduces the cooling requirements of the qubit while maintaining fidelity. |
| FILED | Wednesday, February 17, 2021 |
| APPL NO | 17/904377 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/40 (20220101) Pulse Technique H03K 17/92 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230073547 | Pinello-Benavides et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jacob Pinello-Benavides (Tuscon, Arizona); John Meschberger (Tucson, Arizona); Stephen Moore (El Dorado Hills, California); Edward Little, III (El Dorado Hills, California) |
| ABSTRACT | A propulsion system includes multiple solid rocket motors that are activated by a single initiator. The rocket motors act in parallel, providing thrust in a single direction. The initiator activates an ignition charge that is in or operatively coupled to a plenum that transports hot gasses from the ignition charge to the rockets to be ignited. The plenum may be an annular plenum, which may be located in an annular manifold. The plenum may be an unchoked plenum, allowing flow of hot gasses without choking. The plenum may be lined with an insulator material. A cover may be used to cover the plenum, and also to receive the rocket motors. The rocket motors may be solid-fuel rocket motors. The individual rocket motors may have separate ignition booster charges coupled to the plenum, which are ignited by the ignition charge and which in turn ignite the propellant grains. |
| FILED | Friday, September 03, 2021 |
| APPL NO | 17/466245 |
| CURRENT CPC | Jet-propulsion Plants F02K 9/32 (20130101) F02K 9/95 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230073576 | Cannon et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jeremy Cannon (Philadelphia, Pennsylvania); Christopher Meador (Missouri City, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeremy Cannon (Philadelphia, Pennsylvania); Christopher Meador (Missouri City, Texas) |
| ABSTRACT | A method for tracking and supporting a blood transfusion to a patient. The method includes receiving, by a computing device, current blood product data that identifies a blood product being administered to the patient; updating a current ratio of blood products administered to the patient based on the current blood product data; comparing the current ratio of blood products administered to the patient to a target ratio of blood products to be provided to the patient; determining a next blood product to administer to the patient based on the comparison of the target ratio to the current ratio; and providing, by the computing device, an indication of the determined next blood product. |
| FILED | Tuesday, August 23, 2022 |
| APPL NO | 17/893586 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/02 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) G16H 20/10 (20180101) G16H 20/40 (20180101) G16H 40/20 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230073602 | Akula et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ramya Akula (Orlando, Florida); Ivan Garibay (Orlando, Florida) |
| ABSTRACT | Described, herein, relates to a system and method of accurately and efficiently detecting a tone of a batch of text that achieves both high performance and interpretability by leveraging a multi-head self-attention architecture. The presence of a tone in a batch of text provides a challenge to the performance of a sentiment analysis, since there is an inherent ambiguity in sarcastic expressions that makes sarcasm detection difficult through purely text-based interactions. As such, the multi-head self-attention architecture includes distinct components of routing data through modules comprising data pre-processing, multi-head self-attention, gated recurrent units, and classification, resulting in a modeling system with improved interpretability and accuracy. |
| FILED | Tuesday, June 28, 2022 |
| APPL NO | 17/851851 |
| CURRENT CPC | Electric Digital Data Processing G06F 40/30 (20200101) Original (OR) Class G06F 40/284 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230073983 | Gould |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Benjamin D. Gould (Springfield, Virginia) |
| ABSTRACT | An apparatus having: a polymer electrolyte membrane fuel cell stack capable of generating 1-6 kW and a compressor capable of delivering at least 10 g/s of air at 12 bar. The compressor is coupled to an air inlet of the fuel cell stack. |
| FILED | Thursday, October 27, 2022 |
| APPL NO | 18/050110 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/0267 (20130101) H01M 8/1004 (20130101) Original (OR) Class H01M 2008/1095 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230074175 | PETERSON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan); The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rebecca L. PETERSON (Ann Arbor, Michigan); Ming-Hsun LEE (Ann Arbor, Michigan); Alan G. JACOBS (Rockville, Missouri); Marko J. TADJER (Vienna, Virginia) |
| ABSTRACT | A method for controlling a concentration of donors in an Al-alloyed gallium oxide crystal structure includes implanting a Group IV element as a donor impurity into the crystal structure with an ion implantation process and annealing the implanted crystal structure to activate the Group IV element to form an electrically conductive region. The method may further include depositing one or more electrically conductive materials on at least a portion of the implanted crystal structure to form an ohmic contact. Examples of semiconductor devices are also disclosed and include a layer of an Al-alloyed gallium oxide crystal structure, at least one region including the crystal structure implanted with a Group IV element as a donor impurity with an ion implantation process and annealed to activate the Group IV element, an ohmic contact including one or more electrically conductive materials deposited on the at least one region. |
| FILED | Thursday, September 08, 2022 |
| APPL NO | 17/940231 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/425 (20130101) H01L 21/443 (20130101) H01L 21/465 (20130101) H01L 29/24 (20130101) H01L 29/45 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230074229 | JIA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| INVENTOR(S) | Hongyang JIA (Princeton, New Jersey); Murat OZATAY (Plainsboro, New Jersey); Hossein VALAVI (Franklin Park, New Jersey); Naveen VERMA (Princeton, New Jersey) |
| ABSTRACT | Various embodiments comprise systems, methods, architectures, mechanisms and apparatus for providing programmable or pre-programmed in-memory computing (IMC) operations via an array of configurable IMC cores interconnected by a configurable on-chip network to support scalable execution and dataflow of an application mapped thereto. |
| FILED | Friday, February 05, 2021 |
| APPL NO | 17/797833 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/0611 (20130101) Original (OR) Class G06F 3/0629 (20130101) G06F 3/0659 (20130101) G06F 3/0673 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230074535 | BOHMANN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Southwest Research Institute (San Antonio, Texas); The Government of The United States, as represented by The Secretary of the Army (Fort Detrick, Maryland); The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan A. BOHMANN (San Antonio, Texas); Nadean M. GUTIERREZ (Devine, Texas); Joseph A. MCDONOUGH (Helotes, Texas); Robert Francis CAMPBELL (Edgemere, Maryland); Michael Gordon JOYCE (Silver Spring, Maryland); Rekha PANCHAL (Fort Detrick, Maryland); Rajeshwer SANKHALA (Bethesda, Maryland); Allen DUPLANTIER (Stafford, Virginia) |
| ABSTRACT | Antiviral drugs targeting the N-terminal domain (NTD) of the spike receptor binding domain (RBD) and methods of treating a subject suffering from coronavirus. |
| FILED | Thursday, August 11, 2022 |
| APPL NO | 17/819178 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/445 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230074594 | BLASKOWSKI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Zymergen Inc. (Emeryville, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen BLASKOWSKI (Oakland, California); Robert COATES (Oakland, California); Kedar PATEL (Fremont, California); Hendrik Marinus VAN ROSSUM (Oakland, California); Shawn SZYJKA (Martinez, California) |
| ABSTRACT | A CRISPR system is successfully used to modify the genomes of a gram-positive bacterium, such as a species of the Cornybacterium genus. Methods for modifying Corynebacterium species include single-nucleotide changes, creating gene deletions and/or insertions. |
| FILED | Wednesday, August 03, 2022 |
| APPL NO | 17/817223 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/205 (20210501) C12N 9/22 (20130101) C12N 15/77 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230074730 | DEKLEVA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Brian DEKLEVA (Pittsburgh, Pennsylvania); Jennifer Lynn COLLINGER (Pittsburgh, Pennsylvania) |
| ABSTRACT | Disclosed herein are methods and systems for transient-based decoding of neural signals. In one aspect, a device such as a brain-computer interface (BCI), includes at least one processor configured to receive a plurality of neural signals from a subject. The at least one processor can detect, from the plurality of neural signals, first neural activity unique to a first defined temporal window corresponding to an onset phase of an intended action of the subject. The at least one processor can detect, from the plurality of neural signals, second neural activity unique to a second defined temporal window, occurring after the first temporal window and corresponding to an offset phase of the intended action. The at least one processor can generate at least one output indicative of the intended action, responsive to detecting at least one of the first neural activity or the second neural activity. |
| FILED | Wednesday, September 07, 2022 |
| APPL NO | 17/939893 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/372 (20210101) Electric Digital Data Processing G06F 3/015 (20130101) Original (OR) Class G06F 3/0484 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230075095 | KING et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Neil P. KING (Seattle, Washington); Carl Walkey (Seattle, Washington); Jing Yang Wang (Seattle, Washington); Brooke Fiala (Seattle, Washington); David Veesler (Seattle, Washington); Alexandra C. Walls (Seattle, Washington); Una Nattermann (Seattle, Washington) |
| ABSTRACT | Polypeptides are disclosed herein having significantly improved secretion ability from eukaryotic cells, together with fusion proteins, nanoparticles, and uses thereof, and methods for designing such polypeptides. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/760180 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) Original (OR) Class C07K 2319/03 (20130101) C07K 2319/35 (20130101) C07K 2319/40 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/50 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230076027 | ZANG |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Albert Einstein College of Medicine (Bronx, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xingxing ZANG (New York, New York) |
| ABSTRACT | Provided are methods of treating an autoimmune disease in a subject, or of suppressing transplant rejection in a subject, or of treating a cancer in a subject, as well as compositions therefor. |
| FILED | Thursday, September 15, 2022 |
| APPL NO | 17/932387 |
| CURRENT CPC | Peptides C07K 16/2827 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/24 (20130101) C07K 2319/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230076191 | Tomar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Vikas Tomar (West Lafayette, Indiana); Bing Li (West Lafayette, Indiana); Vilas G. Pol (West Lafayette, Indiana); Ryan Andrew Adams (Redwood City, California); Mihit Hitendra Parekh (West Lafayette, Indiana) |
| ABSTRACT | A method of measuring temperature of a battery having an internally disposed thermal protection arrangement is disclosed which includes providing at least one sensor holder having an electrode side and a housing side disposed within a housing, with at least one cavity provided on the electrode side, providing at least one temperature sensor placed in the at least one cavity of the at least one sensor holder, the outer surface of the at least one temperature sensor being flush with the remaining surface of the at least one sensor holder, attaching the at least one sensor holder to one of a first electrode or a second electrode of the battery, coupling the at least one temperature sensor to a header, and measuring the temperature of the battery. |
| FILED | Tuesday, August 16, 2022 |
| APPL NO | 17/889173 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/382 (20130101) H01M 4/525 (20130101) H01M 4/662 (20130101) H01M 10/486 (20130101) Original (OR) Class H01M 50/411 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230076399 | KAPLAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Perspecta Labs, Inc. (Basking Ridge, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael KAPLAN (Basking Ridge, New Jersey); David SHUR (Basking Ridge, New Jersey); Vikram KAUL (Basking Ridge, New Jersey); Thomas BOWEN (Basking Ridge, New Jersey) |
| ABSTRACT | There is set forth herein obtaining data traffic monitoring data, the data traffic monitoring data being in dependence on monitoring of traffic received by a container of a protected computing environment; obtaining data traffic monitoring data, the data traffic monitoring data being in dependence on monitoring of traffic received by a processing resource of a computing environment; obtaining a state of the processing resource and provisioning a utility processing resource to include the state of the processing resource; and configuring the computing environment to route data traffic to the utility processing resource. |
| FILED | Monday, November 14, 2022 |
| APPL NO | 18/055209 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 41/08 (20130101) H04L 41/0806 (20130101) H04L 43/08 (20130101) H04L 43/16 (20130101) H04L 43/062 (20130101) H04L 43/0876 (20130101) H04L 45/00 (20130101) H04L 47/00 (20130101) H04L 63/10 (20130101) H04L 63/1425 (20130101) Original (OR) Class H04L 63/1491 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230076630 | Aggarwal et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mesoblast International Sárl (Meyrin, Switzerland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sudeepta Aggarwal (North Potomac, Maryland); Mark F. Pittenger (Severna Park, Maryland); Timothy Varney (Baltimore, Maryland) |
| ABSTRACT | Compositions and methods of promoting wound healing in a human by administering to the human mesenchymal stem cells in an effective amount. |
| FILED | Thursday, June 09, 2022 |
| APPL NO | 17/836786 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) Original (OR) Class A61K 38/2026 (20130101) A61K 38/2066 (20130101) A61K 45/06 (20130101) A61K 2035/124 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0662 (20130101) C12N 5/0663 (20130101) C12N 5/0664 (20130101) C12N 5/0665 (20130101) C12N 5/0666 (20130101) C12N 5/0667 (20130101) C12N 5/0668 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230077153 | Kwon et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wichita State University (Wichita, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hyuck M. Kwon (Wichita, Kansas); Ian Ellis L. Hulede (Wichita, Kansas); Andrew Rankin (Wichita, Kansas) |
| ABSTRACT | In a system for determining a location of an emitter, a mobile frame is configured for movement relative to the emitter. A main receiver and a frequency mixing antenna are supported on the mobile frame at different locations on the frame but so that both move with the frame relative to the emitter. The frequency mixing antenna is configured to receive an emitter signal and output a frequency-mixed signal. The main receiver is configured to directly receive the emitter signal and receive the frequency-mixed signal. A processor is configured to determine a first Doppler frequency from the direct emitter signal and a second Doppler frequency from the frequency-mixed signal and to determine the location of the emitter in a defined search area based on the first and second Doppler frequencies. Multiple Doppler frequencies can be created also using multiple frequency mixing antennas to improve the localization resolution. |
| FILED | Thursday, August 18, 2022 |
| APPL NO | 17/820710 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 13/42 (20130101) Original (OR) Class G01S 13/88 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230077230 | Bihl et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Trevor Bihl (Franklin Furnace, Ohio); Chadwick Cox (Madison, Alabama) |
| ABSTRACT | An autonomous mission selection process for improving performance, the process using an Observe, Orient, Decide, and Act model wherein sensors are used for observing a situation and guiding initial mission planning. Aa machine cognitive re-planner assesses inputs, orients, and replans operations including deciding on a payload and determining a route and autonomously acting to direct the mission selected. |
| FILED | Tuesday, August 30, 2022 |
| APPL NO | 17/899244 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 39/024 (20130101) B64C 2201/141 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/0088 (20130101) Original (OR) Class G05D 1/101 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20230070016 | Mazumder et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| INVENTOR(S) | Sudip K. Mazumder (Chicago, Illinois); Moien Mohamadi (Sanandaj, Iran); Nikhil Kumar (New Delhi, India) |
| ABSTRACT | A system for charging a battery includes three sub-modules, each receiving a respective phase of a three-phase alternating current (AC) signal. The three sub-modules cooperate to transform the respective phases of the three-phase AC signal to a direct current (DC) signal by passing the respective phases of the three-phase AC signal through a respective semiconductor device configured to discontinuously modulate the respective phase of the three-phase AC signal to convert it to a DC signal provided to the battery to charge the battery. |
| FILED | Thursday, November 10, 2022 |
| APPL NO | 17/984773 |
| CURRENT CPC | Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/32 (20130101) Original (OR) Class H02M 1/4216 (20130101) H02M 3/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230070074 | Yang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GM Global Technology Operations LLC (Detroit, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jianghuai Yang (Rochester Hills, Michigan); Dale A. Gerard (Bloomfield Hills, Michigan); Qigui Wang (Rochester Hills, Michigan) |
| ABSTRACT | A high elastic modulus, high ultimate tensile strength, and low alloy gray cast iron for cylinder liners. The gray cast iron includes from 2.60 wt % to 3.30 wt % Carbon (C); from 1.50 wt % to 2.30 wt % Silicon (Si); from 0.30 wt % to 0.80 wt % Manganese (Mn); from 0.15 wt % to 0.35 wt % Phosphorus (P); from 0.05 wt % to 0.11 wt % Sulphur (S); from 0.60 wt % to 1.20 wt % Copper (Cu); from 0.10 wt % to 0.30 wt % Chromium (Cr); from greater than 0.0 wt % to 0.1 wt % Nickle (Ni); from 0.15 wt % to 0.40 wt % Molybdenum (Mo); and balance wt % Iron (Fe). The total wt % of Si, Mn, P, S, Cu, Cr, Ni, and Mo is less than about 4.10 wt %. The gray cast iron has a Carbon Equivalent (CE) from 3.00 wt % to 3.90 wt % and the product of Mn %*S % is from 0.025 to 0.045. |
| FILED | Tuesday, August 31, 2021 |
| APPL NO | 17/462527 |
| CURRENT CPC | Alloys C22C 37/08 (20130101) C22C 37/10 (20130101) Original (OR) Class Cylinders, Pistons or Casings, for Combustion Engines; Arrangements of Sealings in Combustion Engines F02F 1/004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230070156 | GROSS |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Westinghouse Electric Company LLC (Cranberry Township, Pennsylvania) |
| ASSIGNEE(S) | Westinghouse Electric Company LLC (Cranberry Township, Pennsylvania) |
| INVENTOR(S) | David M. GROSS (Gibsonia, Pennsylvania) |
| ABSTRACT | A wick assembly for use with a heat pipe is disclosed. The wick assembly includes an end plug including a wick receiving area, a wick, and a crimp. A portion of the wick is positioned about the wick receiving area. The crimp is positioned about the portion of the wick and the wick receiving area. The end plug, the portion of the wick, and the crimp are diffusion bonded. |
| FILED | Tuesday, February 16, 2021 |
| APPL NO | 17/904732 |
| CURRENT CPC | Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 15/046 (20130101) Original (OR) Class Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 2275/061 (20130101) F28F 2275/122 (20130101) Nuclear Reactors G21C 15/257 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230070246 | Bahar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Xergy, Inc. (Harrington, Delaware) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bamdad Bahar (Georgetown, Delaware); Jacob Zerby (Dover, Delaware); Harish Opadrishta (Dover, Delaware); Jason Woods (Boulder, Colorado) |
| ABSTRACT | A tube-in-tube heat exchanger utilizes a selectively permeable tube having a selective permeable layer to allow the refrigerant to transfer into an ionic liquid to generate heating or cooling. The ionic liquid then provides heating or cooling to a heat transfer fluid through a non-permeable layer or tube. The system may be configured as a shell and tube design, with the third fluid free to flow on the outside of the shell, or as a shell and tube-in-tube, with a central tube containing a first liquid, a second tube containing a second liquid, and an outer shell containing the third liquid. The selectively permeable tube may include an anion or cation selectively permeable layer and this layer may be supported by a support layer or tube. |
| FILED | Monday, September 26, 2022 |
| APPL NO | 17/953277 |
| CURRENT CPC | Refrigeration Machines, Plants or Systems; Combined Heating and Refrigeration Systems; Heat-pump Systems F25B 15/14 (20130101) F25B 37/00 (20130101) Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 7/103 (20130101) F28D 20/003 (20130101) F28D 21/0015 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230070273 | LARSON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado); The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bryon William LARSON (Golden, Colorado); Obadiah G. REID (Ft. Collins, Colorado) |
| ABSTRACT | The present disclosure relates to a steady-state microwave conductivity method that includes modulating a light beam to form an amplitude modulated light having a modulation frequency ω1, producing a microwave waveform, exposing a sample to the amplitude modulated light and a first portion of the microwave waveform to produce an amplitude modulation signal on the first portion of the microwave waveform, and mixing a second portion of the microwave waveform and the amplitude modulation signal to produce a first signal and a second signal. |
| FILED | Friday, November 04, 2022 |
| APPL NO | 18/052751 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/2656 (20130101) Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 50/10 (20141201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230070476 | Gahl et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Curators of the University of Missouri (Columbia, Missouri) |
| ASSIGNEE(S) | The Curators of the University of Missouri (Columbia, Missouri) |
| INVENTOR(S) | John Gahl (Columbia, Missouri); John David Robertson (Sturgeon, Missouri); Peter Norgard (Columbia, Missouri); Brad Jeffries (Columbia, Missouri); Valentina O'Donnell (Columbia, Missouri) |
| ABSTRACT | The present invention is directed to processes for ionizing one or more lanthanide isotopes, processes for separating lanthanide isotopes, various apparatus and systems useful for these processes, and compositions prepared from these processes. |
| FILED | Monday, January 31, 2022 |
| APPL NO | 17/589382 |
| CURRENT CPC | Separation B01D 59/48 (20130101) Conversion of Chemical Elements; Radioactive Sources G21G 1/001 (20130101) Original (OR) Class G21G 1/02 (20130101) G21G 2001/0094 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230071028 | Guin |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GUIN TECHNOLOGIES LLC (Tuscaloosa, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tyler Caldwell Guin (Aiken, South Carolina) |
| ABSTRACT | Compositions for forming coatings disclosed herein can include a cationic polyelectrolyte, an anionic polyelectrolyte, nanostructures, and a crosslinking agent. The compositions, coatings, methods, and kits described herein can have improved tribological properties, hardness, and strength. |
| FILED | Friday, January 22, 2021 |
| APPL NO | 17/794084 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 43/36 (20130101) Original (OR) Class Biocidal, Pest Repellant, Pest Attractant or Plant Growth Regulatory Activity of Chemical Compounds or Preparations A01P 1/00 (20210801) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/14 (20130101) C09D 7/20 (20180101) C09D 7/61 (20180101) C09D 7/67 (20180101) C09D 125/18 (20130101) C09D 133/02 (20130101) C09D 139/02 (20130101) C09D 179/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230071083 | Kolkowitz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shimon Kolkowitz (Madison, Wisconsin); Aedan Gardill (Madison, Wisconsin); Matthew Cambria (Madison, Wisconsin) |
| ABSTRACT | A super-resolution microscope avoids the need for complex phase plate optics normally used to produce a doughnut-shaped depletion beam by employing low-intensity regions of common diffraction patterns such as an Airy disk. |
| FILED | Friday, September 03, 2021 |
| APPL NO | 17/466502 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6458 (20130101) G01N 2021/6463 (20130101) Optical Elements, Systems, or Apparatus G02B 5/1842 (20130101) G02B 21/06 (20130101) G02B 21/16 (20130101) G02B 21/365 (20130101) G02B 27/58 (20130101) Original (OR) Class G02B 27/4205 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230072035 | Wu |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wenzhuo Wu (West Lafayette, Indiana) |
| ABSTRACT | An electrochemical sensor that includes a substrate and a piezoelectric semiconductor which is configured to detect ascorbic acid using piezo-electrocatalysis. The piezoelectric semiconductor is coupled to the substrate. The piezoelectric semiconductor includes a nanostructured semiconducting ZnO catalyst. The nanostructured semiconducting ZnO catalyst has a noncentrosymmetric wurtzite configuration. The nanostructured semiconducting ZnO catalyst is shaped as a nanorod and/or a nanosheet. |
| FILED | Monday, June 27, 2022 |
| APPL NO | 17/849840 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/1477 (20130101) A61B 5/6801 (20130101) A61B 5/14546 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/3278 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230072115 | Hatch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| INVENTOR(S) | Jonathan Douglas Hatch (Cleveland, Missouri); Stephen McGarry Hatch (Blue Springs, Missouri) |
| ABSTRACT | A system for providing selective adhesion printed circuit board (PCB) production comprises a conveyor mechanism, a curing system, and a computer. The conveyor mechanism is configured to convey a series of selective adhesion blanks, wherein each selective adhesion blank is utilized to produce a PCB and includes a flexible film, a substrate, a conductive layer, and a curable adhesive. The conductive layer is formed from electrically conductive material and adhered to the substrate. The curable adhesive is positioned between the flexible film and the conductive layer and is configured to selectively bond with the conductive layer when the curable adhesive is cured. The curing system is configured to cure the curable adhesive. The computer includes a processing element configured or programmed to: receive a plurality of PCB designs, and direct the curing system to cure the curable adhesive of a plurality of selective adhesion blanks for each PCB design. |
| FILED | Thursday, September 01, 2022 |
| APPL NO | 17/901417 |
| CURRENT CPC | Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 3/00 (20130101) H05K 3/0005 (20130101) H05K 3/108 (20130101) H05K 3/386 (20130101) H05K 3/1283 (20130101) Original (OR) Class H05K 3/4691 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230072382 | JOLIVET et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PARIS SCIENCES ET LETTRES (Paris, France); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (Paris, France); TRIAD NATIONAL SECURITY, LLC (Los Alamos, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Romain JOLIVET (Cachan, France); Bertrand ROUET-LEDUC (Los Alamos, New Mexico); Paul JOHNSON (South Santa Fe, New Mexico); Claudia HULBERT (Paris, France); Manon DALAISON (Paris, France) |
| ABSTRACT | The invention relates to a method for processing time series of noisy images of a same area, the method comprising: generating a set of time series of images from an input image time series by combining by first linear combinations each pixel of each image of the input image time series with selected neighboring pixels in the image and in an adjacent image of the input image time series; applying filtering operations in cascade to the set, each filtering operation combining each pixel of each image of each time series of the set by second linear combinations with selected neighboring pixels in the image and in an adjacent image in each time series of the set; performing an image combination operation to reduce each time series of the set to a single image; introducing a model image of the area as a filtered image in the set; and combining each image in the set into an output image, by third linear combinations. |
| FILED | Monday, February 15, 2021 |
| APPL NO | 17/904454 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 5/50 (20130101) Original (OR) Class G06T 2207/10044 (20130101) G06T 2207/20024 (20130101) G06T 2207/20221 (20130101) G06T 2207/30181 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230072690 | Hatchett et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, (Las Vegas, Nevada) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David W. Hatchett (Las Vegas, Nevada); Cassara J. Higgins (Las Vegas, Nevada) |
| ABSTRACT | Described herein are methods for recovering lithium metal, lithium hydride, or lithium hydroxide from lithium salts by dissolving the lithium salt in ionic liquids and applying a current to the solution. |
| FILED | Friday, March 05, 2021 |
| APPL NO | 17/795646 |
| CURRENT CPC | Processes for the Electrolytic Production, Recovery or Refining of Metals; Apparatus Therefor C25C 1/22 (20130101) Original (OR) Class C25C 7/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230073091 | Watson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BWXT mPower, Inc. (Charlotte, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ronald C. Watson (Forest, Virginia); John D. Malloy, III (Goode, Virginia) |
| ABSTRACT | A nuclear reactor comprises a pressure vessel containing a nuclear reactor core. A reactor core cooling system comprises a standpipe including a plurality of orifices in fluid communication with a refueling water storage tank (RWST) to drain water from the RWST into the standpipe, and an injection line configured to drain water from the standpipe to the pressure vessel. In some embodiments the standpipe is disposed in the RWST, while in other embodiments the standpipe is disposed outside of the RWST and cross-connection pipes connect the plurality of orifices with the RWST. The reactor core cooling system may further comprise a valve configured to control flow through one orifice of the plurality of orifices in fluid communication with the RWST based on water level in the standpipe. The valve may comprise a float valve having its float disposed in the standpipe. |
| FILED | Tuesday, June 14, 2022 |
| APPL NO | 17/840137 |
| CURRENT CPC | Nuclear Reactors G21C 15/18 (20130101) Original (OR) Class Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 30/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230073101 | Bicer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | HELIAE DEVELOPMENT, LLC (Gilbert, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Taner Bicer (Gilbert, Arizona); Chiliang Chen (Ames, Iowa); Eric Lichtenheld (Gilbert, Arizona); Paul Lim (Chandler, Arizona); Rosaicela Roman Gomez (Gilbert, Arizona); Christopher Tee (Chandler, Arizona); Yan Xu (Tempe, Arizona); Julian Yu (Phoenix, Arizona); Erik Velkme (Tempe, Arizona) |
| ABSTRACT | The present disclosure provides a composition comprising: an extracellular polymeric substance produced by microalgae; plant growth promoting Gram-negative bacteria; and an agriculturally acceptable carrier. Also provided are an isolated biologically pure culture of Parachlorella kessleri Accession No. NCMA 202103001, a mutant thereof having all the identifying characteristics thereof, or a cell-free preparation or extracellular polymeric substance thereof, which may be used for plant enhancement and improving health of soil. |
| FILED | Tuesday, August 02, 2022 |
| APPL NO | 17/816921 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 63/20 (20200101) A01N 65/03 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/125 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230073211 | Torres et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sabrina Marie Wells Torres (Lee's Summit, Missouri); Laura Christine Cummings (Kansas City, Missouri); Connor Daniel Pearson (Overland Park, Kansas) |
| ABSTRACT | A process for forming polymer-grafted nanoparticles is provided. The process utilizes flow chemistry techniques to activate nanoparticle surfaces and then form polymer chains on the activated surfaces in a continuous process, thus avoiding the limitations and shortcomings of batch processes for forming polymer-grafted nanoparticles. The polymer-grafted nanoparticles are particularly useful as a filler or additive in fused deposition modeling (“FDM”) filaments, leading to printed parts having improved properties. |
| FILED | Monday, August 15, 2022 |
| APPL NO | 17/887579 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 41/02 (20130101) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 70/10 (20200101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) B82Y 40/00 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 292/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230073480 | GUZOREK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven GUZOREK (Livermore, California); Adam W. JAYCOX (Livermore, California) |
| ABSTRACT | The present disclosure relates to an adjustable mount apparatus. The apparatus may have a material support having a plurality of support legs, with each one of the support legs having a distal portion. A base assembly is used which has a plurality of laterally extending leg portions. A plurality of adjustably positionable capture subassemblies are slidably disposed within the laterally extending leg portions for releasably coupling to the distal portions of the support legs to hold the material support in a stable manner on the base assembly. A plurality of moveable elements, each being independently associated with one of the capture subassemblies, enable highly controlled linear movement of the capture subassemblies. Each capture subassembly engages with the distal portion of one of the support legs to exert a clamping force thereon, to affix the material support securely to the base assembly. |
| FILED | Friday, September 03, 2021 |
| APPL NO | 17/466809 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/245 (20170801) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 30/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230073509 | Hernandez et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Maira Ceron Hernandez (Brentwood, California); Hannah Violet Eshelman (Dublin, California); Vedasri Vedharathinam (Fremont, California); Marissa Wood (Oakland, California) |
| ABSTRACT | In one embodiment, a system includes a purification stage configured to purify an input gas stream prior to delivering the input gas stream to a reaction stage; and a collection stage configured to collect at least some ammonia from the reaction stage. The reaction stage is configured to reduce nitrogen into nitride; and convert at least some of the nitride into ammonia. In another embodiment, a separation membrane includes: an anode; a cathode electrically coupled to the anode; and a porous support material positioned between the anode and the cathode. The separation membrane is configured to reduce nitrogen into nitride; and facilitate hydrogenation of the nitride to form ammonia. In another embodiment, a method includes delivering an input gas stream comprising nitrogen to a separation membrane; reducing at least some of the nitrogen into nitride; and reacting at least some of the nitride with hydrogen-containing compound(s). |
| FILED | Wednesday, September 08, 2021 |
| APPL NO | 17/469678 |
| CURRENT CPC | Separation B01D 53/02 (20130101) B01D 2256/10 (20130101) B01D 2257/80 (20130101) B01D 2257/104 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/27 (20210101) C25B 1/50 (20210101) C25B 9/19 (20210101) C25B 13/07 (20210101) C25B 13/08 (20130101) Original (OR) Class C25B 15/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230073735 | MUZZILLO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Paul MUZZILLO (Evergreen, Colorado); Matthew Owen REESE (Golden, Colorado) |
| ABSTRACT | Disclosed herein are methods for using cracked film lithography (CFL) for patterning transparent conductive metal grids. CFL can be vacuum- and Ag-free, and it forms more durable grids than nanowire approaches. |
| FILED | Monday, February 15, 2021 |
| APPL NO | 17/759840 |
| CURRENT CPC | Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/0043 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/0463 (20141201) Original (OR) Class H01L 31/1828 (20130101) H01L 31/1884 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230073910 | CHEN |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaowen CHEN (Littleton, Colorado) |
| ABSTRACT | Disclosed herein is 4-chamber microbial electrolysis process and apparatus that recovers lignin, NaOH, and H2 products while removing waste organics from deacetylation and mechanical refining black liquor. |
| FILED | Monday, August 29, 2022 |
| APPL NO | 17/898420 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 3/005 (20130101) C02F 2101/30 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/04 (20130101) C25B 1/16 (20130101) C25B 3/07 (20210101) C25B 5/00 (20130101) C25B 9/19 (20210101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230074774 | PATRA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Susant K. PATRA (Brentwood, California); Jonathan L. DUBOIS (Livermore, California) |
| ABSTRACT | The present disclosure relates to an interconnect system for interfacing an electronic subsystem to a qubit package, wherein the qubit package has a plurality of independent qubits. The system makes use of an optical fiber cable having a plurality of optical fibers, which is interfaced to the electronic subsystem. A 3D optical structure is used which has a plurality of internal waveguides, and which is configured to interface the optical fiber cable to the qubit package. The 3D optical structure further has at least one subsystem for using the plurality of waveguides to receive signals of a first type from at least one of the qubits package or the optical fiber cable, to convert the signals from the first type to a second type, and to transmit the signals in the second type to the other one of the fiber optic cable or the qubit package. |
| FILED | Friday, September 03, 2021 |
| APPL NO | 17/466581 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/4249 (20130101) Original (OR) Class G02B 6/4269 (20130101) Optical Computing Devices; G06E 1/00 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230075724 | Cui et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Yi Cui (Stanford, California); Steven Chu (Menlo Park, California); Chong Liu (Chicago, Illinois) |
| ABSTRACT | Electrochemical methods using intercalation chemistry to extract Li from seawater using the TiO2-coated FePO4 electrode. The difference in the thermodynamic intercalation potentials, as well as the diffusion barriers between Li and Na, could provide near 100% selectivity towards Li interaction when Li/Na molar ratio is higher than 10-3. For lower Li/Na ratio as in the authentic seawater case, pulsed-rest and pulse-rest-reverse pulse-rest electrochemical methods were developed to lower the intercalation overpotential and it was proven to successfully boost the Li selectivity. Moreover, the pulse-rest-reverse pulse-rest method can also promote electrode crystal structure stability during the co-intercalation of Li and Na and prolong the lifetime of the electrode. Finally, 10 cycles of successful and stable Li extraction with 1:1 of Li to Na recovery from authentic seawater were demonstrated, which is equivalent to the selectivity of ˜1.8×104. Also, with lake water of higher initial Li/Na ratio of 1.6×10-3, Li extraction with more than 50:1 of Li to Na recovery was achieved. |
| FILED | Thursday, September 15, 2022 |
| APPL NO | 17/945759 |
| CURRENT CPC | Processes for the Electrolytic Production, Recovery or Refining of Metals; Apparatus Therefor C25C 1/22 (20130101) Original (OR) Class C25C 7/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230075832 | Arafat et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yasir Arafat (Idaho Falls, Idaho); Douglas C. Crawford (Idaho Falls, Idaho); Timothy A. Hyde (Idaho Falls, Idaho); Jess C. Gehin (Idaho Falls, Idaho); James W. Sterbentz (Idaho Falls, Idaho); Robert C. O'Brien (Idaho Falls, Idaho) |
| ABSTRACT | An energy production device may include a core and a heat exchanger positioned over the core. The core may include one or more fuel rods. The core may further include a heat transmission fluid configured to flow through natural convection upwards through the one or more fuel rods and collect heat therefrom. The core may also include a reaction control device including a neutron-absorbing material. The heat exchanger may be configured to receive the heat transmission fluid and transfer the heat to an energy harnessing device positioned on an opposite side of the heat exchanger from the core. |
| FILED | Thursday, January 21, 2021 |
| APPL NO | 17/759332 |
| CURRENT CPC | Nuclear Reactors G21C 5/02 (20130101) G21C 7/06 (20130101) Nuclear Power Plant G21D 1/00 (20130101) Original (OR) Class G21D 9/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230076181 | BRAHMA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CLEMSON UNIVERSITY (CLEMSON, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | SUKUMAR BRAHMA (CLEMSON, South Carolina); MUNIM BIN GANI (CLEMSON, South Carolina) |
| ABSTRACT | Systems and methods of determining fault location on a DC microgrid feeder need to be extremely fast to protect the circuit breaker and converter-source components. This disclosure develops a seminal theoretical foundation for fast fault location on a DC feeder that uses only single-ended local measurements in time domain. The theory provides a closed-form deterministic solution for fault location, making the resulting fault location method agnostic to system-topology and immune to fault resistance. The theory is developed with ideal DC voltage sources and is extended to practical converter-sources. The performance of the resulting method is demonstrated by simulating a DC feeder with converters connected at both ends, modeled in PSCAD (power systems computer-aided design). |
| FILED | Tuesday, August 30, 2022 |
| APPL NO | 17/899173 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 19/2513 (20130101) Emergency Protective Circuit Arrangements H02H 1/0007 (20130101) H02H 3/202 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230076727 | Whalen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Scott A. Whalen (West Richland, Washington); Tianhao Wang (Richland, Washington); Piyush Upadhyay (Richland, Washington); Keerti S. Kappagantula (Richland, Washington) |
| ABSTRACT | Riveted assemblies are provided that can include a substrate extending between two ends to define opposing substrate surfaces having a first opening extending between the opposing substrate surfaces; a metal-comprising substrate extending between two ends to define opposing metal-comprising substrate surfaces having a second opening extending between the opposing metal-comprising substrate surfaces. The riveted assemblies can further provide that the first and second openings complement one another when the substrate and metal-comprising substrate are engaged; and a rivet shaft extends through the openings and engages the substrate with the rivet head and the metal-comprising substrate with the rivet stop head, at least a portion of the stop head being mixed with, and forming a metallurgical bond with the metal-comprising substrate. Assemblies are provided that can include a rivet stop head mixed with, and metallurgically bonded with a metal-comprising substrate. Methods for affixing substrates to one another are also provided. The methods can include providing a substrate defining an opening configured to receive a rivet shaft; providing a metal-comprising substrate defining a complimentary opening; operatively engaging the substrates with the rivet shaft; and forming a stop head from the rivet shaft to affix the substrates. The method further includes that the stop head mixes with, and forms a metallurgical bond with the metal-comprising substrate. Methods for mixing materials to form a metallurgical bond are also provided. The methods can include forming a metallurgical bond between a stop head of a rivet and a metal-comprising substrate. |
| FILED | Thursday, November 03, 2022 |
| APPL NO | 17/979772 |
| CURRENT CPC | Forging; Hammering; Pressing Metal; Riveting; Forge Furnaces B21J 15/02 (20130101) Devices for Fastening or Securing Constructional Elements or Machine Parts Together, e.g Nails, Bolts, Circlips, Clamps, Clips, Wedges, Joints or Jointing F16B 5/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230076771 | DEMUTH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James A. DEMUTH (Woburn, Massachusetts); Andrew J. BAYRAMIAN (Marblehead, Massachusetts); Eric B. DUOSS (Danville, California); Joshua D. KUNTZ (Livermore, California); Christopher SPADACCINI (Oakland, California) |
| ABSTRACT | The present disclosure relates to an apparatus for additively manufacturing a product in a layer-by-layer sequence, wherein the product is formed using powder particles deposited on an interface layer of a substrate. A laser generates first and second beam components. The second beam component has a higher power level and a shorter duration than the first beam component. A mask creates a 2D optical pattern in which only select portions of the second beam components can irradiate the powder particles. The first beam component heats the powder particles close to a melting point, where the particles experience surface tension forces relative to the interface layer. While the particles are heated, the second beam component further heats the particles and also melts the interface layer before the surface tension forces can act on and distort the particles, enabling the particles and the interface layer are able to bond together. |
| FILED | Thursday, November 10, 2022 |
| APPL NO | 17/984786 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/10 (20210101) B22F 12/00 (20210101) Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/066 (20151001) B23K 26/342 (20151001) B23K 26/0622 (20151001) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/153 (20170801) B29C 64/273 (20170801) Original (OR) Class B29C 64/282 (20170801) B29C 64/286 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 10/25 (20151101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230076834 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Navitas Systems, LLC (Lisle, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Binson Li (Ann Arbor, Michigan); Robert Sosik (Ann Arbor, Michigan); Michael Wixom (Ann Arbor, Michigan) |
| ABSTRACT | Provided are methods of producing materials suitable for use as a component of an electrochemical cell such as electrode active layers or solid state electrolyte and/or separator materials. Processes include combining an active with a fibrillizable binder and intermixing in a screw fibrillator to produce a fibrillized material with greatly increased physical and optionally electrochemically characteristics relative to those materials produced by other processes such as simple slurry casting or intermixing in a jet mill. |
| FILED | Monday, March 01, 2021 |
| APPL NO | 17/905374 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/18 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/04 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/62 (20130101) H01M 4/0433 (20130101) Original (OR) Class H01M 10/0525 (20130101) H01M 2004/021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20230069973 | Cruttenden et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Corey Edward Cruttenden (Minneapolis, Minnesota); Rajesh Rajamani (Saint Paul, Minnesota); Wei Chen (Plymouth, Minnesota); Xiao-Hong Zhu (Plymouth, Minnesota); Mahdi Ahmadi (Minneapolis, Minnesota) |
| ABSTRACT | A device includes a substrate, an electrode, an electrical pad, and a signal line. The signal line is coupled to the substrate and covered by an insulation layer. The signal line is coupled to the electrical pad and the electrode. At least one of the electrode and the signal line includes a diamagnetic material and paramagnetic material, wherein a ratio of the diamagnetic material and the paramagnetic material is selected based on the susceptibility properties of a physiological tissue. The term paramagnetic herein refers to magnetic susceptibility greater than that of the surrounding tissue and diamagnetic refers to magnetic susceptibility lower than that of the tissue. |
| FILED | Tuesday, August 16, 2022 |
| APPL NO | 17/820115 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/24 (20210101) A61B 5/6868 (20130101) A61B 5/6877 (20130101) A61B 5/7207 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/086 (20170801) A61N 1/0534 (20130101) Original (OR) Class A61N 1/0551 (20130101) A61N 1/36103 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230070364 | THOSTENSON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF DELAWARE (NEWARK, Delaware) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ERIK THOSTENSON (NEWARK, Delaware); THOMAS SCHUMACHER (PORTLAND, Oregon) |
| ABSTRACT | Processes for depositing functionalized nanoparticles upon a non-conductive substrate are disclosed herein. The processes may include the step of aerosolizing one or more particles into suspension within a gas, each of the one or more particles comprising functionalized nanoparticles having an electric charge. The processes may include the step the step of attracting the one or more particles onto a non-conductive substrate by a static electric charge opposite of the electric charge, wherein at least portions of the non-conductive substrate are having the static electric charge. The processes may include the step of depositing the functionalized nanoparticles onto the non-conductive substrate |
| FILED | Wednesday, November 09, 2022 |
| APPL NO | 17/983818 |
| CURRENT CPC | Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials C03C 25/44 (20130101) Original (OR) Class Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/4419 (20130101) C09D 7/61 (20180101) Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 13/02 (20130101) C25D 13/12 (20130101) C25D 13/22 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/254 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230071386 | Kim et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nam Sung Kim (Champaign, Illinois); Mohammad Alian (Urbana, Illinois) |
| ABSTRACT | A computing device includes a host processor to execute a host driver to create a host-side interface, the host-side interface emulating a first Ethernet interface, assign the host-side interface a first medium access control (MAC) address and a first Internet Protocol (IP) address. Memory components are disposed on a substrate. A memory channel network (MCN) processor is disposed on the substrate and coupled between the memory components and the host processor. The MCN processor is to execute an MCN driver to create a MCN-side interface, the MCN-side interface emulating a second Ethernet interface. The MCN processor is to assign the MCN-side interface a second MAC address and a second IP address, which identify the MCN processor as a MCN network node to the host processor. |
| FILED | Friday, November 04, 2022 |
| APPL NO | 17/980685 |
| CURRENT CPC | Electric Digital Data Processing G06F 12/10 (20130101) G06F 13/1673 (20130101) G06F 13/4027 (20130101) Original (OR) Class G06F 2212/1016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230071834 | Horns et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard F. Horns (Pasadena, California); Michael B. Elowitz (Pasadena, California) |
| ABSTRACT | Disclosed herein include methods, compositions, and kits suitable for use in the measurement of the states of living cells across time. There are provided, in some embodiments, RNA exporter proteins comprising an RNA-binding domain, a membrane-binding domain, and an interaction domain capable of nucleating self-assembly. Disclosed herein include polynucleotides encoding reporter RNA molecule(s). In some embodiments, a plurality of RNA exporter proteins are capable of self-assembling into lipid-enveloped nanoparticles (LNs) secreted from a reporter cell in which the RNA exporter proteins are expressed, thereby generating a population of LNs comprising exported reporter RNA molecule(s). |
| FILED | Tuesday, August 16, 2022 |
| APPL NO | 17/820235 |
| CURRENT CPC | Peptides C07K 2319/02 (20130101) C07K 2319/03 (20130101) C07K 2319/85 (20130101) C07K 2319/735 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/62 (20130101) C12N 15/111 (20130101) C12N 15/1086 (20130101) Original (OR) Class C12N 2320/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20230072201 — MOBILE ROBOT CONFIGURED TO DETERMINE HUMAN ARM STIFFNESS DURING OVERGROUND INTERACTION
| US 20230072201 | Regmi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Curators of the University of Missouri (Columbia, Missouri) |
| ASSIGNEE(S) | The Curators of the University of Missouri (Columbia, Missouri) |
| INVENTOR(S) | Sambad Regmi (Rolla, Missouri); Yun Seong Song (St. Louis, Missouri) |
| ABSTRACT | A mobile robot system and method for determining the stiffness of a human arm while moving with a user during overground interaction as the user holds the robot's handle and exchanges forces with it. A mobile base moves with the user, a robot arm interacts with the user, and a controller determines the stiffness. The robot arm includes servomotors driving a linkage mechanism, an end effector including the handle supported by the linkage mechanism, and a force transducer measuring a force applied by the user to the handle. The controller causes the robot arm to generate a force perturbation at the handle, measure a peak velocity achieved by the human arm, determine the stiffness of the human arm as a function of force and displacement, and control operation of the system based on the determined stiffness. A robot body may allow for adjusting the height of the robot arm. |
| FILED | Wednesday, September 07, 2022 |
| APPL NO | 17/939698 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 5/007 (20130101) B25J 9/1633 (20130101) B25J 11/009 (20130101) B25J 13/085 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230072400 | Bajpai et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shivam Bajpai (Tempe, Arizona); Jianming Liang (Scottsdale, Arizona) |
| ABSTRACT | Described herein are means for generating pre-trained models for nnU-Net through the use of improved transfer learning techniques, in which the pre-trained models are then utilized for the processing of medical imaging. According to a particular embodiment, there is a system specially configured for segmenting medical images, in which such a system includes: a memory to store instructions; a processor to execute the instructions stored in the memory; wherein the system is specially configured to: execute instructions via the processor for executing a pre-trained model from Models Genesis within a nnU-Net framework; execute instructions via the processor for learning generic anatomical patterns within the executing Models Genesis through self-supervised learning; execute instructions via the processor for transforming an original image using distortion and cutout-based methods; execute instructions via the processor for learning the reconstruction of the original image from the transformed image using an encoder-decoder architecture of the nnU-Net framework to identify the generic anatomical representation from the transformed image by recovering the original image; and wherein architecture determined by the nnU-Net framework is utilized with Models Genesis and is trained to minimize the L2 distance between the prediction and ground truth. Other related embodiments are disclosed. |
| FILED | Wednesday, September 07, 2022 |
| APPL NO | 17/939783 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30096 (20130101) Image or Video Recognition or Understanding G06V 10/467 (20220101) G06V 10/768 (20220101) G06V 10/7715 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230072446 | SESSLER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| INVENTOR(S) | Jonathan L. SESSLER (Austin, Texas); Zachariah PAGE (Austin, Texas); Hu WANG (Austin, Texas) |
| ABSTRACT | The present disclosure relates to strapped calixpyrrole compounds, polymer monomers and polymers comprising strapped calixpyrrole substructures, and compositions thereof. Also provided herein are methods of use of said strapped calixpyrrole compounds, polymer monomers, and polymers, such as for the selective extraction of specific salts. |
| FILED | Friday, July 29, 2022 |
| APPL NO | 17/816270 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 4/00 (20130101) Original (OR) Class C08G 63/06 (20130101) C08G 67/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230072824 | Akono et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ange-Therese Akono (Evanston, Illinois); Jiaxin Chen (Evanston, Illinois) |
| ABSTRACT | Methods for making carbon-fiber reinforced geopolymer composites are provided. The methods produce metakaolin-based geopolymer composites in which multiwalled carbon nanotubes and/or carbon nanofibers are well dispersed in an metakaolin-based geopolymer matrix. The mixing protocols of the methods used to produce carbon-fiber reinforced geopolymer composites produce composites with reduced porosity, high elastic moduli, high strength, and/or high fracture toughness. |
| FILED | Friday, January 29, 2021 |
| APPL NO | 17/792502 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 14/026 (20130101) C04B 28/006 (20130101) Original (OR) Class C04B 2111/00181 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230073324 | Lew et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Matthew Lew (St. Louis, Missouri); Tingting Wu (St. Louis, Missouri); Tianben Ding (St. Louis, Missouri) |
| ABSTRACT | Systems, devices and methods for determining an orientation and a rotational mobility of the single point emitter using a duo-spot point spread function (PSF) phase mask are disclosed. The duo-spot PSF phase mask includes at least three partitions, in which each partition includes a phase delay ramp aligned along one of two phase delay axes. Each phase delay ramp includes a gradient of phase delays. Each partition includes a subset of a total area of the phase mask and the two phase delay axes are oriented in different directions. The duo-spot PSF phase mask is configured to produce a duo-spot PSF that includes two light spots. The relative brightness of the two spots encodes an orientation and a rotational mobility of the single point emitter. |
| FILED | Tuesday, February 16, 2021 |
| APPL NO | 17/800171 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6458 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230073364 | MALIK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| INVENTOR(S) | Hafiz MALIK (Ann Arbor, Michigan); Syed IRTAZA (Ann Arbor, Michigan) |
| ABSTRACT | Traditional speaker verification systems are vulnerable to voice spoofing attacks, such as voice-replay attack, voice-cloning attack, and cloned-replay attack. To overcome these vulnerabilities, a secure automatic speaker verification system based on a novel sign modified acoustic local ternary pattern (sm-ALTP) features and asymmetric bagging-based classifier-ensemble with enhanced attack vector is presented. The proposed audio representation approach clusters the high and low frequency components in audio frames by normally distributing them against a convex function. Afterwards, the neighborhood statistics are applied to capture the user specific vocal tract information. |
| FILED | Tuesday, January 12, 2021 |
| APPL NO | 17/792283 |
| CURRENT CPC | Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 17/04 (20130101) Original (OR) Class G10L 17/06 (20130101) G10L 25/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230073429 | KUMTA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania); CONCURRENT TECHNOLOGIES CORPORATION (Johnstown, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania); CONCURRENT TECHNOLOGIES CORPORATION (Johnstown, Pennsylvania) |
| INVENTOR(S) | Prashant N. KUMTA (Pittsburgh, Pennsylvania); Abhijit ROY (Pittsburgh, Pennsylvania); Howard Arthur KUHN (Butler, Pennsylvania); Matthew CRIADO (Latrobe, Pennsylvania); John Michael OHODNICKI (East Pittsburgh, Pennsylvania); Brock T. GOLESICH (Johnstown, Pennsylvania); Juan J. VALENCIA (Montclair, New Jersey); Michael John POLLOCK (Boswell, Pennsylvania); Michael L. TIMS (Barboursville, Virginia) |
| ABSTRACT | The invention relates to a device and method for preparing a structure or object using an additive manufacturing process referred to as sequential cold spray laser sintering. The method includes depositing by cold spraying a plurality of sequential layers of material onto a substrate/build plate or particles of materials onto a compacted powder bed of material and employing an energy source to sinter or melt each of the plurality of sequential layers or powders to produce sequential sintered layers, wherein the number of additional layers is determined based on those needed to produce the final structure. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/795383 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/56 (20130101) Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/25 (20210101) Original (OR) Class B22F 10/38 (20210101) B22F 10/66 (20210101) B22F 12/41 (20210101) B22F 12/53 (20210101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230073771 | HE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Jin HE (Miami, Florida); Popular PANDEY (Miami, Florida) |
| ASSIGNEE(S) | The Florida International University Board of Trustees (Miami, Florida) |
| INVENTOR(S) | Jin HE (Miami, Florida); Popular PANDEY (Miami, Florida) |
| ABSTRACT | A system and method for electrical label-free detection of single protein molecules via a nanoscale electrode based on detecting the transient potential change of the floating nanoelectrode, which works for both large and small molecules. The system can also be applied to study the interactions of molecules with molecular receptors on the surface of the nanoscale electrode. The motion and dynamics of the protein near the nanoscale electrode can be detected with high precision in real time based on their intrinsic charges by the potentiometric method using a differential amplifier. The nanoelectrode can be integrated into a microfluidic device for biosensing applications. |
| FILED | Wednesday, September 08, 2021 |
| APPL NO | 17/468966 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 2300/16 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1031 (20130101) G01N 33/557 (20130101) G01N 33/5306 (20130101) Original (OR) Class G01N 33/5438 (20130101) G01N 2015/1006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230074584 | Chiou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul Chiou (Los Angeles, California); Ali Alotaibi (Los Angeles, California); William Halfond (Los Angeles, California) |
| ABSTRACT | A method for detecting and/or localizing keyboard accessibility failures (KAFs) in a web page is disclosed. A web page is rendered in a browser on a display portion of a computing system. A keyboard navigation flow graph based on based on keyboard-based navigation of a user with the web page. A second point-click navigation flow graph based on mouse-based navigation of the user with the web page. One or more KAFs are determined based on a comparison of the first graphical model with the second graphical model. |
| FILED | Friday, August 19, 2022 |
| APPL NO | 17/891695 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/0238 (20130101) Original (OR) Class G06F 16/9577 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230074892 | Turner et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul Turner (New Haven, Connecticut); Alita Burmeister (Hamden, Connecticut); Benjamin Chan (Salt Lake City, Utah); Kaitlyn Kortright (New Haven, Connecticut); John Wertz (Cheshire, Connecticut) |
| ABSTRACT | The present invention includes compositions and methods for increasing antibiotic sensitivity and/or decreasing virulence in bacteria. |
| FILED | Thursday, May 07, 2020 |
| APPL NO | 17/609225 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/76 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230074958 | Ebert et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Frederik David Ebert (Berkeley, California); Akhil Amar Padmanabha (San Jose, California); Stephen Tian (San Jose, California); Roberto Calandra (Fremont, California); Sergey Vladimir Levine (Berkeley, California) |
| ABSTRACT | Optical tactile sensors are provided that include a scaffolding structure, a transparent elastomer material covering at least an end portion of the scaffolding structure, and one or multiple cameras situated on the end portion of the scaffolding structure and embedded within the transparent elastomer material, wherein the one or multiple cameras are situated so as to provide an extended, e.g., up to 360°, field of view about the end portion of the scaffolding structure. |
| FILED | Tuesday, April 19, 2022 |
| APPL NO | 17/723640 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 13/084 (20130101) B25J 19/023 (20130101) Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 5/166 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230075490 | REN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| INVENTOR(S) | Fengbo REN (Tempe, Arizona); Kai XU (Tempe, Arizona); Zhikang ZHANG (Mesa, Arizona) |
| ABSTRACT | This disclosure addresses the single-image compressive sensing (CS) and reconstruction problem. A scalable Laplacian pyramid reconstructive adversarial network (LAPRAN) facilitates high-fidelity, flexible and fast CS image reconstruction. LAPRAN progressively reconstructs an image following the concept of the Laplacian pyramid through multiple stages of reconstructive adversarial networks (RANs). At each pyramid level, CS measurements are fused with a contextual latent vector to generate a high-frequency image residual. Consequently, LAPRAN can produce hierarchies of reconstructed images and each with an incremental resolution and improved quality. The scalable pyramid structure of LAPRAN enables high-fidelity CS reconstruction with a flexible resolution that is adaptive to a wide range of compression ratios (CRs), which is infeasible with existing methods. |
| FILED | Tuesday, October 11, 2022 |
| APPL NO | 18/045740 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/084 (20130101) G06N 3/0454 (20130101) G06N 20/20 (20190101) Image Data Processing or Generation, in General G06T 3/4046 (20130101) Original (OR) Class G06T 5/50 (20130101) G06T 2207/20016 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230075643 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts); College of William & Mary (Williamsburg, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yanzhi Wang (Newton Highlands, Massachusetts); Zhengang Li (Boston, Massachusetts); Bin Ren (Jamestown, Virginia); Wei Niu (Jamestown, Virginia) |
| ABSTRACT | BPDNN is a general end-to-end framework to achieve real-time DNN execution on mobile devices. BPDNN supports both CNNs and RNNs. It is based on a novel, fine-grained structured BCR pruning to obtain high execution efficiency without compromising accuracy. BPDNN has two main stages: a compiler-based stage to generate optimized execution codes by leveraging BCR pruning information, and an optimization framework to determine the block size and other hyperparameters based on a decoupling strategy. |
| FILED | Tuesday, February 16, 2021 |
| APPL NO | 17/797610 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/082 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230075934 | Chan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yee Jher Chan (Ames, Iowa); Adam Russell Carr (Ames, Iowa); Nigel Forest Reuel (Ames, Iowa) |
| ABSTRACT | An inductive-capacitive resonant sensor architecture includes an inductively-coupled extender (ICE) that can both increase read range and lessen the effects of reader/sensor misalignment. The ICE can include a first coil configured with respect to a resonant sensor and a second coil separated from the first coil and coupled to the first coil by electrical wires. An external reader can be arranged with respect to the second coil. This architecture can nearly eliminate misalignment issues between the external reader and the resonant sensor. The ICE can be implemented with a closed circuit design. Additional apparatus, systems, and methods are disclosed. |
| FILED | Thursday, August 18, 2022 |
| APPL NO | 17/820753 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/025 (20130101) G01N 27/223 (20130101) Original (OR) Class G01N 27/228 (20130101) G01N 33/246 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230076378 | Diebold et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BECTON, DICKINSON AND COMPANY (FRANKLIN LAKES, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric D. Diebold (Menlo Park, California); Keegan Owsley (Campbell, California); Jonathan Lin (San Gabriel, California) |
| ABSTRACT | In one aspect, a method of sorting cells in a flow cytometry system is disclosed, which includes illuminating a cell with radiation having at least two optical frequencies shifted from one another by a radiofrequency to elicit fluorescent radiation from the cell, detecting the fluorescent radiation to generate temporal fluorescence data, and processing the temporal fluorescence data to arrive at a sorting decision regarding the cell without generating an image (i.e., a pixel-by-pixel image) of the cell based on the fluorescence data. In other words, while the fluorescence data can contain image data that would allow generating a pixel-by-pixel fluorescence intensity map, the method arrives at the sorting decision without generating such a map. In some cases, the sorting decision can be made with a latency less than about 100 microseconds. In some embodiments, the above method of sorting cells can have a sub-cellular resolution, e.g., the sorting decision can be based on characteristics of a component of the cell. In some embodiments in which more than two frequency-shifted optical frequencies are employed, a single radiofrequency shift is employed to separate the optical frequencies while in other such embodiments a plurality of different radiofrequency shifts are employed. |
| FILED | Tuesday, September 27, 2022 |
| APPL NO | 17/953976 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/147 (20130101) G01N 15/1429 (20130101) G01N 15/1434 (20130101) Original (OR) Class G01N 21/6402 (20130101) G01N 21/6428 (20130101) G01N 2015/1006 (20130101) G01N 2015/1447 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230076395 | Horns et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard F. Horns (Pasadena, California); Michael B. Elowitz (Pasadena, California); Joe A. Martinez (Pasadena, California) |
| ABSTRACT | Disclosed herein include methods, compositions, and kits suitable for use in the delivery of polyribonucleotides and circuits. There are provided, in some embodiments, RNA exporter proteins comprising an RNA-binding domain, a membrane-binding domain, and an interaction domain capable of nucleating self-assembly. Disclosed herein include polynucleotides encoding cargo RNA molecule(s). In some embodiments, a plurality of RNA exporter proteins are capable of self-assembling into lipid-enveloped nanoparticles (LNs) secreted from a sender cell in which the RNA exporter proteins are expressed, thereby generating a population of LNs comprising a fusogen and exported cargo RNA molecule(s). |
| FILED | Tuesday, August 16, 2022 |
| APPL NO | 17/820232 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) C07K 2319/85 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 15/88 (20130101) Original (OR) Class C12N 15/625 (20130101) C12N 2740/13022 (20130101) C12N 2740/13042 (20130101) C12N 2740/16022 (20130101) C12N 2740/16042 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230076403 | Steinmetz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicole F. Steinmetz (San Diego, California); Frank Alexander Veliz (Cleveland, Ohio); Brylee David B. Tiu (Cleveland, Ohio) |
| ABSTRACT | A nanoparticle construct includes a plurality of plant virus or virus-like particles electrostatically coupled to a plurality of nanoparticles having a different surface charge than the plant virus or virus-like particles. The nanoparticle construct upon delivery to a subject can provide a sustained release of the plant virus or virus-like particles and/or nanoparticles to a cell or tissue of the subject. |
| FILED | Tuesday, September 06, 2022 |
| APPL NO | 17/903286 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) Original (OR) Class A61K 39/39 (20130101) A61K 39/385 (20130101) A61K 47/6901 (20170801) A61K 2039/585 (20130101) A61K 2039/622 (20130101) A61K 2039/645 (20130101) A61K 2039/5258 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230076513 | Macfarlane et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Robert J. Macfarlane (Cambridge, Massachusetts); Joshua Kubiak (Somerville, Massachusetts) |
| ABSTRACT | Composites comprising polymer grafted particles that are capable of forming interparticle interactions, and related methods, are generally described. |
| FILED | Monday, June 06, 2022 |
| APPL NO | 17/833644 |
| CURRENT CPC | Treatment of Inorganic Materials, Other Than Fibrous Fillers, to Enhance Their Pigmenting or Filling Properties; Preparation of Carbon Black; C09C 1/407 (20130101) C09C 1/3072 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20230070600 | Abdallah et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut); The United states of America as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chadi Abdallah (New Haven, Connecticut); John Krystal (New Haven, Connecticut); Ronald Duman (New Haven, Connecticut); Gerard Sanacora (New Haven, Connecticut) |
| ABSTRACT | The present invention provides compositions and methods for treating diseases or disorders using a therapeutically effective amount of a rapid-acting antidepressant (RAAD) and a therapeutically effective amount of a mTOR inhibitor and/or immunosuppressant. In certain embodiments, the RAAD and the mTOR inhibitor and/or immunosuppressant are part of a single pharmaceutical composition. |
| FILED | Tuesday, October 25, 2022 |
| APPL NO | 18/049589 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/08 (20130101) A61K 9/0053 (20130101) A61K 31/135 (20130101) A61K 31/436 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/24 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230073041 | Samadani et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia); HENNEPIN HEALTHCARE SYSTEMS, INC (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Uzma Samadani (Minneapolis, Minnesota); Abdullah Bin ZAHID (Minneapolis, Minnesota); David P. Darrow (Minneapolis, Minnesota) |
| ABSTRACT | A surgical navigation system may include a processor and a display. The processor may receive a patient image and sensor data captured by a sensor, receive a medical image, generate a hologram of the medical image, perform coregistration between the patient image and the hologram, superimpose the hologram on the patient image, and display the superimposed image. Coregistration may be performed manually via a user interaction, or automatically based on one or more fiducials in the medical image and sensor data related to the fiducials. The system may monitor a change in the environment and update the display correspondingly. For example, the system may monitor a movement of a body of the patient, monitor the size of an organ of the patient as the organ is being under operation, or a movement of the surgical instrument. The sensor may be an augmented reality (AR) sensor in an AR device. |
| FILED | Thursday, November 10, 2022 |
| APPL NO | 17/984651 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 34/20 (20160201) Original (OR) Class Electric Digital Data Processing G06F 17/16 (20130101) Image Data Processing or Generation, in General G06T 19/006 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101) G16H 40/63 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230075368 | Habib |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States Govemment as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amyn Habib (Dallas, Texas) |
| ABSTRACT | The present disclosure is concerned with the use of agents that modulate bridging integrator 3 (BIN3) signaling and/or janus kinase 3 (JAK3) signaling for treating various gliomas such as, for example, glioblastoma. The present disclosure is also concerned with the use of agents that increase levels of EGFR ligand (e.g., tofacitinib, EGFR ligands) for treating gliomas, and, in particular, for treating EGFR amplified gliomas. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| FILED | Friday, February 19, 2021 |
| APPL NO | 17/800210 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/137 (20130101) A61K 31/437 (20130101) A61K 31/495 (20130101) A61K 31/506 (20130101) A61K 31/517 (20130101) A61K 31/519 (20130101) Original (OR) Class A61K 38/1796 (20130101) A61K 38/1808 (20130101) A61K 38/1841 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230077104 | Oates et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERAN AFFAIRS (Washington, District of Columbia); MUSC FOUNDATION FOR RESEARCH DEVELOPMENT D/B/A ZUCKER INSTITUTE FOR INNOVATION (Charleston, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Oates (Charleston, South Carolina); Joy Jones Buie (Charleston, South Carolina) |
| ABSTRACT | The present invention provides compositions and methods for increasing nitric oxide production for treating or preventing a chronic inflammatory autoimmune disease or disorder. |
| FILED | Friday, February 19, 2021 |
| APPL NO | 17/800207 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/04 (20130101) A61K 31/275 (20130101) A61K 31/345 (20130101) A61K 31/519 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20230070933 | Pugia et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven M. Pugia (Lafayette, Indiana); Anthony G. Cofer (Lafayette, Indiana); Alina Alexeenko (West Lafayette, Indiana) |
| ABSTRACT | A microthruster for controlling small spacecraft and methods for manufacturing the same are disclosed. Embodiments of the microthruster include one or more nozzle throats with cross sectional areas of at most 20 μm2, and some with 6 μm2. Some embodiments include heaters that heat water in one or more reservoirs to increase pressure in the reservoirs and eject the water from the one or more nozzle throats. Some embodiments are manufactured by etching channels into one or more layers of material, and still further embodiments are manufactured by forming the nozzle throats and/or the reservoirs between two layers of material. Some microthruster embodiments are flat in shape with the nozzle throats ejecting water out the thin sides of the microthruster. Still further embodiments are formed by etching channels into one layer of material, printing a heater onto another layer of material, and bonding the two layers together. |
| FILED | Tuesday, September 07, 2021 |
| APPL NO | 17/447061 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/409 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230073890 | Harman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Stone Aerospace, Inc. (Del Valle, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Harman (Keyser, West Virginia); Frederick M. Smith (Lavale, Maryland); William C. Stone (Del Valle, Texas) |
| ABSTRACT | A direct high voltage flow-through water heater system transmits high voltage power to a remote ice penetrating robot, converts the power to heat in a very small space, and then uses the heat to melt the ice, providing a path ahead of the robot allowing penetration deeper into a remote ice-covered location, such ice of substantial (e.g., kilometers) thickness, such as, for example, glacial ice caps. High voltage, low current, AC power is passed through a moving conducting fluid, inducing resistive heating in the fluid with 100% efficiency. The exiting fluid is stripped of common mode voltage before exiting. Energy transfer from the electrical source to the fluid is instantaneous and occurs at 100% efficiency. In an alternative embodiment, the fluid heater system operates at standard residential/industrial mains voltages and runs from 220 VAC as other applications of the present invention include the traditional water heater industry as well. |
| FILED | Tuesday, November 08, 2022 |
| APPL NO | 18/053533 |
| CURRENT CPC | Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 7/008 (20130101) E21B 7/15 (20130101) Fluid Heaters, e.g Water or Air Heaters, Having Heat Generating Means, in General F24H 1/106 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230075112 | Zha et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | COFLOW JET, LLC (Cutler Bay, Florida); UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gecheng Zha (Cutler Bay, Florida); Siena Whiteside (Hampton, Virginia); Beau Pollard (Hampton, Virginia); Michael Patterson (Hampton, Virginia); Xiaofan Fei (Hampton, Virginia); Paul Rothhaar (Hampton, Virginia); Kevin Antcliff (Hampton, Virginia); Steven Geuther (Hampton, Virginia) |
| ABSTRACT | An example of a deflected slip stream wing system with coflow jet flow control includes a wingbox, a flap, a compressor, and a propulsor. The wingbox has a root and a tip. The flap is moveably attached to the wingbox and has a leading edge, a trailing edge, an injection opening, a suction opening, and a channel. The injection opening is disposed between the leading edge and the suction opening. The suction opening is disposed between the injection opening and the trailing edge. The channel extends from the injection opening to the suction opening. The compressor is disposed within the channel. The propulsor is disposed on the wingbox between the root and the tip. The propulsor has an off state and an on state. When in the on state, the propulsor is aligned relative to the flap such that fluid accelerated by the propulsor contacts the flap. |
| FILED | Thursday, June 30, 2022 |
| APPL NO | 17/854499 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 9/146 (20130101) B64C 21/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20230071444 | Yang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NUtech Ventures (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yiqi Yang (Lincoln, Nebraska); Bingnan Mu (Lincoln, Nebraska); Faqrul Hassan (Dhaka, Bangladesh) |
| ABSTRACT | This disclosure relates to processes for preparing a keratin fiber, for example, continuous process. In some embodiments, a process as described herein can comprise extruding a keratin solution into a first solution to form a first fiber; drawing the first fiber and oxidizing the first fiber to form a treated fiber; drawing the treated fiber and oxidizing the treated fiber one or more times; and setting the treated fiber to form the keratin fiber. Such processes can be useful for preparing a keratin fiber with a high draw ratio. |
| FILED | Thursday, January 21, 2021 |
| APPL NO | 17/794548 |
| CURRENT CPC | Chemical Treatment of Natural Filamentary or Fibrous Material to Obtain Filaments or Fibres for Spinning; Carbonising Rags to Recover Animal Fibres D01C 3/00 (20130101) Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/12 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 4/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230074483 | Jassby et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Jassby (Los Angeles, California); Arpita Iddya (Los Angeles, California); Eric M.V. Hoek (Los Angeles, California) |
| ABSTRACT | An ion exchange membrane includes nanoparticulate hydrous manganese oxide, wherein, the ion exchangemembrane is selective for the passage of phosphate ion. Methods of preparing ion exchange membranes and methods of seprating phosate also are described. |
| FILED | Tuesday, September 06, 2022 |
| APPL NO | 17/903567 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 39/05 (20170101) B01J 39/18 (20130101) B01J 47/12 (20130101) Original (OR) Class B01J 47/018 (20170101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 20230070364 | THOSTENSON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF DELAWARE (NEWARK, Delaware) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ERIK THOSTENSON (NEWARK, Delaware); THOMAS SCHUMACHER (PORTLAND, Oregon) |
| ABSTRACT | Processes for depositing functionalized nanoparticles upon a non-conductive substrate are disclosed herein. The processes may include the step of aerosolizing one or more particles into suspension within a gas, each of the one or more particles comprising functionalized nanoparticles having an electric charge. The processes may include the step the step of attracting the one or more particles onto a non-conductive substrate by a static electric charge opposite of the electric charge, wherein at least portions of the non-conductive substrate are having the static electric charge. The processes may include the step of depositing the functionalized nanoparticles onto the non-conductive substrate |
| FILED | Wednesday, November 09, 2022 |
| APPL NO | 17/983818 |
| CURRENT CPC | Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials C03C 25/44 (20130101) Original (OR) Class Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/4419 (20130101) C09D 7/61 (20180101) Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 13/02 (20130101) C25D 13/12 (20130101) C25D 13/22 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/254 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Reconnaissance Office (NRO)
| US 20230074229 | JIA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| INVENTOR(S) | Hongyang JIA (Princeton, New Jersey); Murat OZATAY (Plainsboro, New Jersey); Hossein VALAVI (Franklin Park, New Jersey); Naveen VERMA (Princeton, New Jersey) |
| ABSTRACT | Various embodiments comprise systems, methods, architectures, mechanisms and apparatus for providing programmable or pre-programmed in-memory computing (IMC) operations via an array of configurable IMC cores interconnected by a configurable on-chip network to support scalable execution and dataflow of an application mapped thereto. |
| FILED | Friday, February 05, 2021 |
| APPL NO | 17/797833 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/0611 (20130101) Original (OR) Class G06F 3/0629 (20130101) G06F 3/0659 (20130101) G06F 3/0673 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20230075195 | Chornenky |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NOKOMIS, INC. (Canonsburg, Pennsylvania) |
| ASSIGNEE(S) | NOKOMIS, INC. (Canonsburg, Pennsylvania) |
| INVENTOR(S) | Todd Eric Chornenky (Carmichaels, Pennsylvania) |
| ABSTRACT | A receiver includes a circuit designed to process, based on a plurality of timed waveform reference locations, a waveform signal, the waveform signal comprising a message. The circuit may include a clock source, an input configured to receive the waveform signal, a time location reference circuit coupled to the clock source, the time location reference circuit designed to output the plurality of timed waveform reference locations, each timed waveform reference location being set by the clock, and a signal processing circuit coupled to the time location reference circuit, the signal processing circuit designed to generate an output voltage in a response to the waveform signal being inputted into the signal processing circuit through the input and processed at each timed waveform reference location from the series of timed waveform reference locations. A transmitter that generates the waveform signal can be also provided where the clocks are matched. |
| FILED | Thursday, September 08, 2022 |
| APPL NO | 17/940493 |
| CURRENT CPC | Transmission H04B 1/16 (20130101) H04B 17/336 (20150115) Transmission of Digital Information, e.g Telegraphic Communication H04L 7/0012 (20130101) Original (OR) Class H04L 7/0037 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20230073841 | Luckay et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan M. Luckay (Washington, District of Columbia); Robert E. Dixon, JR. (Washington, District of Columbia); James E. Lee, SR. (Washington, District of Columbia) |
| ABSTRACT | Systems and methods of tracking distribution items using hardware components on or in the distribution items. Shippers and recipients of distribution items can track or locate a distribution item, especially a high value item, if the distribution item is lost, misrouted, or delayed. |
| FILED | Monday, November 14, 2022 |
| APPL NO | 18/055354 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 7/10108 (20130101) G06K 19/025 (20130101) G06K 19/07758 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 20/28 (20130101) G06Q 50/28 (20130101) Original (OR) Class Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 3/1016 (20130101) G08B 21/0275 (20130101) Wireless Communication Networks H04W 12/47 (20210101) H04W 24/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
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How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, March 09, 2023.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
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FUNDED BY
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Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
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3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
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The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
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