FedInvent™ Patent Applications
Application Details for Thursday, March 23, 2023
This page was updated on Thursday, March 23, 2023 at 11:34 AM GMT
Department of Health and Human Services (HHS)
| US 20230085899 | GAO et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | The Board of Regents of The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Jinming GAO (Plano, Texas); David BOOTHMAN (, None); Kejin ZHOU (Dallas, Texas); Xiaonan HUANG (Beijing, China PRC); Yiguang WANG (Dallas, Texas) |
| ABSTRACT | Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises wherein R′ is —H or —CH3, wherein R is —NR1R2, wherein R1 and R2 are alkyl groups, wherein R1 and R2 are the same or different, wherein R1 and R2 together have from 5 to 16 carbons, wherein R1 and R2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications. |
| FILED | Friday, July 01, 2022 |
| APPL NO | 17/810591 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1075 (20130101) A61K 9/1273 (20130101) A61K 9/5031 (20130101) A61K 31/337 (20130101) A61K 31/352 (20130101) A61K 31/704 (20130101) A61K 47/58 (20170801) A61K 47/62 (20170801) A61K 47/6811 (20170801) A61K 47/6845 (20170801) A61K 47/6907 (20170801) A61K 49/005 (20130101) A61K 49/0032 (20130101) A61K 49/0054 (20130101) A61K 49/0056 (20130101) A61K 49/0082 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 311/92 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 293/005 (20130101) Original (OR) Class C08F 299/024 (20130101) C08F 2438/01 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 81/025 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/582 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230086091 | Greenberg et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zachary F. Greenberg (Gainesville, Florida); Mei He (Gainesville, Florida); Kiley S. Graim (Gainesville, Florida) |
| ABSTRACT | Various embodiments generally relate to intelligently designing aptameric peptides for binding with a specific receptor and forming aptameric peptide libraries with the designed peptides. The aptameric peptides libraries can be tissue-specific and be used in drug delivery and therapeutic applications, in which designed peptides can be implanted on exosome surfaces for exosomal cargo delivery to a specific tissue. Various embodiments of the present disclosure involve the use of a generative adversarial network (GAN) machine learning model configured (e.g., trained) and used to output designed peptides that are similar to pre-existing peptides of a peptide dataset but that specifically bind to a selected receptor and have various selected physiochemical properties. In various embodiments, GAN machine learning models may receive representations of the pre-existing peptides and may output representations of designed peptides according to peptide vectorization and encoding schemas based at least in part on the amino acids within a peptide. |
| FILED | Tuesday, September 06, 2022 |
| APPL NO | 17/903287 |
| CURRENT CPC | Peptides C07K 1/047 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230086188 | Dzuricky et al. |
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| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Dzuricky (Durham, North Carolina); Ashutosh Chilkoti (Durham, North Carolina) |
| ABSTRACT | Described herein are peptide biopolymers that exhibit controlled phase separation based on their amino acid sequence, aromatic:aliphatic ratio, hydrophobicity, temperature, molecular weight, and concentration. |
| FILED | Wednesday, March 03, 2021 |
| APPL NO | 17/908427 |
| CURRENT CPC | Peptides C07K 14/435 (20130101) Original (OR) Class C07K 2319/35 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230086199 | Liu et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David R. Liu (Cambridge, Massachusetts); Jordan Leigh Doman (Cambridge, Massachusetts); Aditya Raguram (Cambridge, Massachusetts) |
| ABSTRACT | The instant specification provides novel assays and systems for determining off-target effects of base editors. These assays and systems may comprise bacterial and/or eukaryotic cell systems and may be used to determine off-target editing frequencies, including Cas9-independent off-target editing frequencies. Also provided herein are novel base editors, wherein the base editors have reduced Cas9-independent off-target editing frequencies while maintaining high on-target editing efficiencies. Further provided are methods of contacting a nucleic acid molecule with these base editors to obtain reduced off-target editing frequencies, and in particular reduced Cas9-independent off-target editing events. Further provided are methods of treatment comprising administering these base editors to a subject. Also provided are pharmaceutical compositions comprising the base editors described herein, and nucleic acids, vectors, cells, and kits useful for the generation of these base editors. |
| FILED | Wednesday, November 25, 2020 |
| APPL NO | 17/779953 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/111 (20130101) C12N 2310/20 (20170501) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6827 (20130101) Original (OR) Class Enzymes C12Y 305/04005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230086332 | Huang et al. |
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| FUNDED BY |
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| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
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| INVENTOR(S) | Chengwu Huang (Rochester, Minnesota); Shigao Chen (Rochester, Minnesota) |
| ABSTRACT | Described here are systems and methods for ultrasound clutter filtering to produce images of blood flow in a subject. The systems and methods described in the present disclosure may be advantageously applied to fast ultrasound imaging techniques, including ultrafast plane wave imaging techniques. |
| FILED | Thursday, February 11, 2021 |
| APPL NO | 17/799321 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/06 (20130101) A61B 8/5207 (20130101) Original (OR) Class A61B 8/5269 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 15/8915 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230086506 | Agarwal et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MIAMI (Miami, Florida) |
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| INVENTOR(S) | Ashutosh Agarwal (Miami Beach, Florida); Vera Mayo (Miami, Florida); Matthew Ishahak (Miami, Florida) |
| ABSTRACT | A microfluidic structure includes a first media channel or well and a second media channel. A removable membrane is provided between the first media channel or well and the second media channel to permit diffusion. One or more plates is used to form the second media channel. A method of creating a microenvironment using the microfluidic structure is also provided. |
| FILED | Friday, March 05, 2021 |
| APPL NO | 17/909303 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) Original (OR) Class C12M 23/16 (20130101) C12M 25/06 (20130101) C12M 35/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230086695 | Bhadra et al. |
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| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
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| INVENTOR(S) | Niloy Bhadra (Cleveland Heights, Ohio); Kevin L. Kilgore (Avon Lake, Ohio); Narendra Bhadra (Chesterland, Ohio); Jesse Wainright (Willoughby Hills, Ohio); Tina Vrabec (Willoughby Hills, Ohio); Manfred Franke (South Euclid, Ohio) |
| ABSTRACT | Devices and methods for blocking signal transmission through neural tissue. One step of a method includes placing a therapy delivery device into electrical communication with the neural tissue. The therapy delivery device includes an electrode contact having a high charge capacity material. A multi-phase direct current (DC) can be applied to the neural tissue without damaging the neural tissue. The multi-phase DC includes a cathodic DC phase and anodic DC phase that collectively produce a neural block and reduce the charge delivered by the therapy delivery device. The DC delivery can be combined with high frequency alternating current (HFAC) block to produce a system that provides effective, safe, long term block without inducing an onset response. |
| FILED | Monday, November 21, 2022 |
| APPL NO | 17/991045 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/06 (20130101) A61N 1/20 (20130101) A61N 1/0556 (20130101) Original (OR) Class A61N 1/36064 (20130101) A61N 1/36067 (20130101) A61N 1/36071 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230086710 | Ding et al. |
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| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaozhe Ding (Pasadena, California); Viviana Gradinaru (La Canada Flintridge, California) |
| ABSTRACT | Disclosed herein include methods and compositions comprising variant AAV capsids. Variant capsid proteins, including variant capsid proteins with structure-guided deletion/substitution, tandem multimers, and/or variant capsid proteins with structure-guided deletion and C-terminal insertion, are provided in some embodiments. The variant capsid proteins disclosed herein are capable of assembling into a variant AAV capsid with an expanded size (e.g., diameter) and/or genetic cargo capacity. Methods of treating diseases and disorders using said rAAV are also disclosed. |
| FILED | Tuesday, September 13, 2022 |
| APPL NO | 17/931808 |
| CURRENT CPC | Peptides C07K 14/075 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2750/14122 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230087228 | Zhang et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Feng Zhang (Cambridge, Massachusetts); Han Altae-Tran (Cambridge, Massachusetts); Soumya Kannan (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides novel class 1, Type IV and novel class I, Type I Cas proteins and their use in modifying target sequences. |
| FILED | Wednesday, February 24, 2021 |
| APPL NO | 17/801815 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/14 (20130101) C12N 9/22 (20130101) Original (OR) Class C12N 15/11 (20130101) C12N 15/86 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) C12N 2750/14143 (20130101) C12N 2800/80 (20130101) Enzymes C12Y 306/04012 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230087299 | WELLMAN et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
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| INVENTOR(S) | David Andrew WELLMAN (Boston, Massachusetts); Scott Aaron SANDS (Boston, Massachusetts); Ali AZARBARZIN (Boston, Massachusetts) |
| ABSTRACT | A method for endo-phenotyping and risk stratifying obstructive sleep apnea (OSA) incudes acquiring signals associated with breathing over a period of time from a subject. In some embodiments, the signals associated with breathing are oxygen saturation signals (SpO2) that can be acquired using a SpO2 sensor. In some embodiments, the signals associated with breathing are snoring signals that can be acquired using an acoustic sensor. The method further includes determining at least one endo-phenotype of OSA using the acquired signals associated with breathing. In some embodiments, SpO2 signals can be used to determine endo-phenotypes including pharyngeal collapsibility, arousal threshold, ventilatory instability, hypoxic burden, and heart rate burden. In some embodiments, snoring signals can be used to determine endo-phenotypes including a site of airway collapse. |
| FILED | Monday, May 03, 2021 |
| APPL NO | 17/922661 |
| CURRENT CPC | Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/40 (20180101) Original (OR) Class G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230087396 | Hartigan-O'Connor |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of The University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of The University of California (Oakland, California) |
| INVENTOR(S) | Dennis J. Hartigan-O'Connor (Davis, California) |
| ABSTRACT | Methods and compositions are disclosed for inducing immune responses against one or more antigens in a mammal. |
| FILED | Tuesday, November 15, 2022 |
| APPL NO | 18/055808 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/215 (20130101) Original (OR) Class A61K 39/001111 (20180801) A61K 2039/53 (20130101) A61K 2039/6056 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2710/16143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230087558 | WISNIEWSKI |
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| APPLICANT(S) | NEW YORK UNIVERSITY (New York, New York) |
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| INVENTOR(S) | Thomas WISNIEWSKI (Staten Island, New York) |
| ABSTRACT | The present application discloses a method of inhibiting the onset of cerebral amyloid angiopathy (CAA) and associated conditions in a subject including administering, to a subject at risk of developing CAA, an antibody-based molecule that binds to GPIIIa49-66 on activated platelets, under conditions effective to inhibit formation of platelet micro-clots, thereby inhibiting the onset of CAA and associated conditions. Also described is a method of reducing cerebral vascular platelet micro-clots in a subject in need thereof and a combination therapeutic that includes an antibody-based molecule that binds to GPIIIa49-66 on activated platelets, and an Alzheimer's disease therapeutic. |
| FILED | Thursday, August 11, 2022 |
| APPL NO | 17/819059 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Peptides C07K 16/28 (20130101) Original (OR) Class C07K 2317/565 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230087562 | Zhang et al. |
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| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
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| INVENTOR(S) | Lilei Zhang (Cleveland Heights, Ohio); Mukesh K. Jain (Solon, Ohio); Thomas Burris (Columbia, Illinois) |
| ABSTRACT | A method of treating cardiac hypertrophy and/or heart failure in a subject includes administering to the subject a therapeutically effective amount of a REV-ERBα agonist. |
| FILED | Tuesday, July 19, 2022 |
| APPL NO | 17/868257 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0053 (20130101) A61K 31/381 (20130101) A61K 31/4025 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230087578 | KIM et al. |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland); University of Washington (Seattle, Washington) |
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| INVENTOR(S) | Deok-Ho KIM (Baltimore, Maryland); Alex JIAO (Seattle, Washington); Nisa P. WILLIAMS (Seattle, Washington) |
| ABSTRACT | Provided herein is a method for making a tissue engineering scaffold. The method includes layering at least one sheet of cells onto a flexible scaffold, casting the sheets into geometries, and thereby creating the tissue engineering scaffold. Preferred geometry are non-linear (i.e. not a substantially flat surface such as may be provided by a flat glass substrate). The flexible scaffold is characterized by tensile strength, viscosity, stress, strain, modulus of polymers, or any combination thereof. |
| FILED | Saturday, February 13, 2021 |
| APPL NO | 17/800494 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/12 (20130101) A61K 35/34 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/38 (20130101) Original (OR) Class A61L 27/52 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0657 (20130101) C12N 5/0658 (20130101) C12N 5/0691 (20130101) C12N 5/0697 (20130101) C12N 2506/45 (20130101) C12N 2539/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230087766 | Jiang et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Guochun Jiang (Davis, California); Satya Dandekar (Davis, California) |
| ABSTRACT | Methods of reactivating latent human immunodeficiency virus (HIV) in one or more cells of a patient infected with HIV are provided. Methods of treating HIV infection and acquired immune deficiency syndrome (HIV/AIDS) in a patient are also provided. The methods can include administering a crotonylation-inducing agent to the patient. The methods can also include administering a crotonylation-inducing agent and one or more additional latency reversal agents (LRAs) to the patient. Pharmaceutical compositions including a crotonylation-inducing agent or pharmaceutical compositions including a crotonylation-inducing agent and one or more additional LRAs are also provided. |
| FILED | Thursday, June 09, 2022 |
| APPL NO | 17/806236 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/44 (20130101) Original (OR) Class A61K 39/42 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Enzymes C12Y 103/01008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230087931 | Ng et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); THE UNIVERSITY OF SOUTHERN MISSISSIPPI (Hattiesburg, Mississippi) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tse Nga Ng (San Diego, California); Lulu Yao (San Diego, California); Jason Azoulay (Hattiesburg, Mississippi) |
| ABSTRACT | Embodiments of the presently disclosed technology provide a synergistic combination of a conjugated open-shell donor-acceptor polymer with a carbon-based compound (e.g., reduced graphene oxide) to produce a composite electrode material which demonstrates state-of-the-art capacitance and potential window, with excellent kinetics and cycle life. The conjugated open-shell donor-acceptor polymer may comprise a plurality of alternating electron-rich monomers (i.e., donors) and electron-deficient monomers (i.e., acceptors) bonded together via a conjugated backbone. The conjugated backbone may comprise a connection of n-orbitals of the plurality of monomers in alternating single and double bonds that facilitates unpaired electron delocalization—thereby stabilizing charge for the polymer. The carbon-based compound of the composite electrode material may provide porous, conductive scaffolds for the composite electrode material, resulting in electrodes scalable to microns-thick films with fast kinetics. |
| FILED | Tuesday, June 14, 2022 |
| APPL NO | 17/840124 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 61/126 (20130101) Original (OR) Class C08G 2261/44 (20130101) C08G 2261/124 (20130101) C08G 2261/514 (20130101) C08G 2261/3223 (20130101) C08G 2261/3246 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/042 (20170501) C08K 2201/001 (20130101) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/32 (20130101) H01G 11/48 (20130101) H01G 11/86 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230087977 | Fan et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yong Fan (Bala Cynwyd, Pennsylvania); Hongming Li (Philadelphia, Pennsylvania) |
| ABSTRACT | Methods and systems for analyzing images are disclosed. An example method may comprise inputting one or more of a first image or a second image into a fully convolutional network, and determining an updated fully convolutional network by optimizing a similarity metric associated with spatially transforming the first image to match the second image. The one or more values of the fully convolutional network may be adjusted to optimize the similarity metric. The method may comprise registering one or more of the first image or the second image based on the updated fully convolutional network. |
| FILED | Friday, May 27, 2022 |
| APPL NO | 17/826567 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6215 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 7/33 (20170101) G06T 2207/10081 (20130101) G06T 2207/10088 (20130101) G06T 2207/20081 (20130101) Image or Video Recognition or Understanding G06V 10/25 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230087994 | Spiegel et al. |
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| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Spiegel (New Haven, Connecticut); David Caianiello (Brooklyn, New York); Jake Swartzel (New Haven, Connecticut) |
| ABSTRACT | The present disclosure provides, in one aspect, bifunctional compounds that can be used to promote or enhance degradation of certain circulating proteins. In another aspect, the present disclosure provides bifunctional compounds that can be used to promote or enhance degradation of certain autoantibodies. In certain embodiments, treatment or management of a disease and/or disorder requires degradation, removal, or reduction in concentration of the circulating protein or the autoantibody in the subject. Thus, in certain embodiments, administration of a compound of the disclosure to the subject removes or reduces the circulation concentration of the circulating protein or the autoantibody, thus treating, ameliorating, or preventing the disease and/or disorder. In certain embodiments, the circulating protein is TNF. |
| FILED | Tuesday, March 15, 2022 |
| APPL NO | 17/654990 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/55 (20170801) Original (OR) Class A61K 47/58 (20170801) A61K 47/60 (20170801) A61K 47/545 (20170801) A61K 47/548 (20170801) A61K 47/549 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230088123 | Thakare et al. |
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| FUNDED BY |
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| APPLICANT(S) | Energy and Environmental Research Center Foundation (Grand Forks, North Dakota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jivan Thakare (Grand Forks, North Dakota); Jahangir Masud (Grand Forks, North Dakota) |
| ABSTRACT | Composites including silica phase and magneli-phase titanium suboxide, supported catalyst particles including the same, electrodes including the supported catalyst particles, and electrochemical cells including the electrode. |
| FILED | Monday, September 19, 2022 |
| APPL NO | 17/933311 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/925 (20130101) Original (OR) Class H01M 8/1004 (20130101) H01M 2300/0065 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230088127 | Mushti et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chandrasekhar Mushti (Germantown, Maryland); Deepak Sail (Potomac, Maryland); Rolf Eric Swenson (Silver Spring, Maryland); Murali Krishna Cherukuri (Potomac, Maryland); Shingo Matsumoto (Sapporo City, Japan); Aparna Kesarwala (Altanta, Georgia) |
| ABSTRACT | A compound of the Formula I or a pharmaceutically acceptable salt thereof, wherein R1, Ca, Cb, Cd, and n are the same as described in the specification. Disclosed is a method of diagnosing or monitoring a patient suffering from cancer, the method comprising: administering a pharmaceutical composition comprising an effective amount of an active agent, wherein the active agent is the compound of Formula I, a pharmaceutically acceptable salt of any of the foregoing thereof, or a combination thereof, together with a pharmaceutically acceptable carrier to the patient and diagnosing or monitoring the patient by hyperpolarized 13C-MRI. Also disclosed is a method of synthesizing 1-13C-5-12C-diacid. |
| FILED | Friday, January 15, 2021 |
| APPL NO | 17/793089 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) A61K 51/0402 (20130101) General Methods of Organic Chemistry; Apparatus Therefor C07B 59/001 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230088509 | Peng et al. |
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| FUNDED BY |
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| APPLICANT(S) | St. Jude Children's Research Hospital (Memphis, Tennessee) |
| ASSIGNEE(S) | St. Jude Children's Research Hospital (Memphis, Tennessee) |
| INVENTOR(S) | Junmin Peng (Memphis, Tennessee); Hong Wang (Memphis, Tennessee); Kaushik Kumar Dey (Memphis, Tennessee) |
| ABSTRACT | This disclosure relates to compositions and methods of diagnosing neurodegenerative disease by analyzing protein expression profiles in a subject. |
| FILED | Wednesday, May 19, 2021 |
| APPL NO | 17/999165 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) Original (OR) Class G01N 2800/52 (20130101) G01N 2800/60 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230088546 | WEISS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THERMALIN INC. (Waban, Massachusetts); CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael A. WEISS (Indianapolis, Indiana); Mentor MULAJ (North Ridgeville, Ohio); Laurie A. BROADWATER (Kent, Ohio); Thomas HATTIER (Cleveland Heights, Ohio); Richard BERENSON (Waban, Massachusetts) |
| ABSTRACT | A pharmaceutical composition comprises an effective amount of an insulin analogue comprising modified A-chain and B-chain polypeptides. The modified A chain comprises one or more substitutions relative to wild-type human insulin A-chain selected from a Gln, His or Glu substitution at position A8, a Glu or Ala substitution at position A14, and an Ala, Gln, Gly, or Thr substitution at position A21. The modified B-chain polypeptide comprises one or more modifications relative to wild-type human insulin B-chain selected from a deletion of the amino acid or amino acids at position B1, B1 and B2, or B1-B3, an Ala or Glu substitution at position B2, a Glu or Ala substitution at position B3, an Ala substitution at position B4; and a Glu or Lys substitution at position B29. The composition comprises one or more of iloprost, citrate, EDTA and a polyphosphate compound. The composition may be used to treat diabetes. |
| FILED | Tuesday, March 02, 2021 |
| APPL NO | 17/909054 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/194 (20130101) A61K 31/198 (20130101) A61K 31/5578 (20130101) A61K 33/42 (20130101) A61K 38/28 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230088583 | Sherman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David H. Sherman (Ann Arbor, Michigan); Kathleen L. Collins (Ann Arbor, Michigan); Andrew W. Robertson (Ann Arbor, Michigan); Mark m. Painter (Ann Arbor, Michigan) |
| ABSTRACT | Provided herein are compounds that can inhibit MHC-I downmodulation, and treat HIV infection in a patient in need of treatment thereof. |
| FILED | Wednesday, December 16, 2020 |
| APPL NO | 17/785809 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/366 (20130101) Original (OR) Class A61K 31/7048 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230088633 | Smith et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Children's Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lois Smith (West Newton, Massachusetts); Zhongjie Fu (Brookline, Massachusetts) |
| ABSTRACT | The instant disclosure provides methods and compositions related to discovery of a long-acting FGF21 as a therapeutic target for treatment or prevention of neovascular eye diseases or disorders that are characterized by angiogenesis, or of vascular diseases of the eye. Therapeutic and/or prophylactic uses and compositions of long-acting FGF21 are described. |
| FILED | Friday, April 22, 2022 |
| APPL NO | 17/727120 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 38/1825 (20130101) Original (OR) Class A61K 47/60 (20170801) A61K 47/6811 (20170801) A61K 47/6879 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230088763 | ABIDIAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Houston System (Houston, Texas) |
| ASSIGNEE(S) | University of Houston System (Houston, Texas) |
| INVENTOR(S) | Mohammad Reza ABIDIAN (Houston, Texas); Omid DADRAS-TOUSSI (Houston, Texas); Milad KHORRAMI (Hayward, California); Sheereen MAJD (Houston, Texas) |
| ABSTRACT | The present disclosure describes a new resin which can be fabricated into conductive and bioactive microstructures via two-photon polymerization. The direct incorporation of conductive poly (3,4-ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT:PSS) and/or multi-walled carbon nanotubes (MWCNTs) in a poly(ethylene glycol) diacrylate (PEGDA)-based blend remarkably enhances the electrical conductivity of microstructures over 10 orders of magnitude. Including biomaterials in the resin can promote cellular adhesion and create functional biosensors made of hybrid non-conductive and conductive structures for sensitive detection. Applications include development cost effective microelectronics in a broad range of biomedical research, electronics and sensors. |
| FILED | Friday, September 16, 2022 |
| APPL NO | 17/932889 |
| CURRENT CPC | Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/52 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/54373 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230088835 | Mirkin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chad A. Mirkin (Wilmette, Illinois); Sasha B. Ebrahimi (DeKalb, Illinois); Devleena Samanta (Evanston, Illinois) |
| ABSTRACT | The present disclosure is directed to spherical nucleic acids (SNAs) comprising a nanoparticle core and an oligonucleotide, use of the SNAs to, e.g., detect target analytes, and methods of making the SNAs. In various embodiments, the target analyte is detected using the nanoparticle core, the oligonucleotide, or both. In some embodiments, the oligonucleotide comprises a detectable marker situated at an internal location within the oligonucleotide. In some aspects, the disclosure provides methods for detecting a target analyte comprising the step of contacting the target analyte with a spherical nucleic acid (SNA) and an agent, the SNA comprising a protein core and an oligonucleotide attached thereto, wherein the contacting of the protein core with the target analyte results in a change in the target analyte that is detectable by the agent, thereby detecting the target analyte. |
| FILED | Monday, July 20, 2020 |
| APPL NO | 17/908809 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/535 (20130101) G01N 33/5308 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230089068 | KALNIK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ANTIDOTE THERAPEUTICS, INC. (Bethesda, Maryland); BliNK BIOMEDICAL (Marseille, France); Hennepin Healthcare Research Institute (Minneapolis, Minnesota) |
| ASSIGNEE(S) | ANTIDOTE THERAPEUTICS, INC. (Bethesda, Maryland); BliNK BIOMEDICAL (Marseille, France); Hennepin Healthcare Research Institute (Minneapolis, Minnesota) |
| INVENTOR(S) | Matthew W. KALNIK (Gaithersburg, Maryland); Thomas THISTED (Gaithersburg, Maryland); Nicola BELTRAMINELLI (Marseille, France); Stéphanie FALLOT (Marseille, France); Zuzana BIESOVA (Bethesda, Maryland); Steve FULLER (Bethesda, Maryland); Mark G. LeSAGE (Minneapolis, Minnesota); Paul PENTEL (Minneapolis, Minnesota) |
| ABSTRACT | Described are novel nicotine-binding antibodies and methods of using them for treating nicotine addiction and/or facilitating smoking cessation, or for treating nicotine overdose or nicotine poisoning. |
| FILED | Friday, August 12, 2022 |
| APPL NO | 17/819577 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 47/60 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/34 (20180101) Peptides C07K 16/44 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230089221 | Prusiner et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Stanley B. Prusiner (San Francisco, California); Jacob I. Ayers (San Francisco, California); Nick A. Paras (San Francisco, California) |
| ABSTRACT | An assay is disclosed based on the successful transmission of DLB, and to a much lesser extent PD, to cultured HEK cells expressing the A53T and E46K point mutation. DLB prion activity was achieved by treatment of brain homogenates with detergent extraction and limited proteolysis followed by polyoxometalate precipitation of the prions. The results show the MSA strain of α-synuclein prions differs from those causing PD and DLB. Manipulating dominant negative inhibition of α-synuclein prions has created a new approach to identifying novel prions and deciphering the features of their multiplication. |
| FILED | Tuesday, September 13, 2022 |
| APPL NO | 17/943988 |
| CURRENT CPC | Peptides C07K 1/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) Original (OR) Class G01N 2001/2866 (20130101) G01N 2333/4703 (20130101) G01N 2800/2835 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230089465 | Robbins et al. |
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| FUNDED BY |
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| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Paul F. Robbins (Chevy Chase, Maryland); Steven A. Rosenberg (Bethesda, Maryland); Xin Yao (Rockville, Maryland) |
| ABSTRACT | The invention provides an isolated or purified T-cell receptor (TCR) having antigenic specificity for MHC Class II-restricted MAGE-A3. The invention further provides related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells. Further provided by the invention are antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention. Methods of detecting the presence of cancer in a host and methods of treating or preventing cancer in a mammal are further provided by the invention. |
| FILED | Wednesday, September 28, 2022 |
| APPL NO | 17/936006 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1774 (20130101) A61K 39/0005 (20130101) A61K 2039/585 (20130101) Peptides C07K 14/7051 (20130101) Original (OR) Class C07K 14/70514 (20130101) C07K 16/00 (20130101) C07K 16/2809 (20130101) C07K 2319/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57492 (20130101) G01N 2333/47 (20130101) G01N 2333/7051 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230089497 | ZHANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qi ZHANG (Tempe, Arizona); Xiao WANG (Chandler, Arizona); Alexander GREEN (Chestnut Hill, Massachusetts); Duo MA (Tempe, Arizona); Fuqing WU (Tempe, Arizona); Kylie STANDAGE-BEIER (Phoenix, Arizona); Xingwen CHEN (Tempe, Arizona) |
| ABSTRACT | The present invention provides a new class of RNA modules, referred to as degradation tuning RNAs (dtRNAs), which form stabilizing secondary structures. Also provided are methods of using dtRNAs to modulate the stability of RNAs. DNA constructs including a promoter that is operably connected to a sequence encoding the dtRNA are also provided. |
| FILED | Wednesday, March 03, 2021 |
| APPL NO | 17/909345 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/67 (20130101) Original (OR) Class C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230089516 | KALYANSUNDARAM |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ramaswamy KALYANSUNDARAM (Rockford, Illinois) |
| ABSTRACT | The present invention is a multivalent immunogenic composition for immunizing an animal against filariasis. In some embodiments, the antigens of the multivalent immunogenic composition are protein-based, DNA-based, or a combination thereof. This invention also provides a method and kit for detecting a filarial nematode and determining vaccine efficacy. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/798189 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0003 (20130101) Original (OR) Class A61K 2039/53 (20130101) A61K 2039/70 (20130101) A61K 2039/552 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 33/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230089654 | Childs et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Richard W. Childs (Rockville, Maryland); David S.J. Allan (Rockville, Maryland); Chantiya Chanswangphuwana (Bangkok, Thailand) |
| ABSTRACT | Modified natural killer (NK) or T cells expressing hematopoietic growth factor receptors are provided. In some embodiments, the NK cells or T cells express a thrombopoietin receptor or an erythropoietin receptor. Methods of treating a subject with cancer are also provided, including administering the modified NK cells or T cells to the subject in combination with a thrombopoietin receptor agonist or erythropoietin receptor agonist, and in some example, interleukin-2, particularly reduced or low-dose amounts of IL-2. |
| FILED | Tuesday, August 23, 2022 |
| APPL NO | 17/821703 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230089949 | Birder et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Lori Birder (Pittsburgh, Pennsylvania); Edwin Kerry Jackson (Pittsburgh, Pennsylvania); Amanda Wolf-Johnston (Evans City, Pennsylvania); José-Alain Sahel (Pittsburgh, Pennsylvania); Yuanyuan Chen (Pittsburgh, Pennsylvania) |
| ABSTRACT | Disclosed herein are methods of treating age-related retinal diseases by administering to the subject a therapeutically effective amount of a purine nucleoside phosphorylase (PNPase) inhibitor and/or a PNPase purine nucleoside substrate. In some examples, the subject can have AMD or glaucoma. |
| FILED | Monday, April 19, 2021 |
| APPL NO | 17/799546 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/522 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230089966 | Shusta et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric Shusta (Madison, Wisconsin); Benjamin Gastfriend (Madison, Wisconsin); Sean Palecek (Verona, Wisconsin) |
| ABSTRACT | The present invention provides in vitro methods of differentiating brain mural cells and methods of use, including use in blood brain barrier models. Suitable in vitro derived cell populations of brain mural cells are also provided. |
| FILED | Tuesday, September 20, 2022 |
| APPL NO | 17/933730 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/069 (20130101) Original (OR) Class C12N 15/86 (20130101) C12N 2500/90 (20130101) C12N 2502/00 (20130101) C12N 2506/03 (20130101) C12N 2740/15043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230090221 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David R. Liu (Cambridge, Massachusetts); Andrew Vito Anzalone (Cambridge, Massachusetts); Gregory Newby (Cambridge, Massachusetts); Kelcee Everette (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure provides compositions and methods for conducting prime editing of a target DNA molecule (e.g., a genome) that enables the incorporation of a nucleotide change and/or targeted mutagenesis. The nucleotide change can include a single-nucleotide change (e.g., any transition or any transversion), an insertion of one or more nucleotides, or a deletion of one or more nucleotides. More in particular, the disclosure provides fusion proteins comprising nucleic acid programmable DNA binding proteins (napDNAbp) and a polymerase (e.g., reverse transcriptase), which is guided to a specific DNA sequence by a modified guide RNA, named an PEgRNA. The PEgRNA has been altered (relative to a standard guide RNA) to comprise an extended portion that provides a DNA synthesis template sequence which encodes a single strand DNA flap, which is homologous to a strand of the targeted endogenous DNA sequence to be edited, but which contains the desired one or more nucleotide changes and which, following synthesis by the polymerase (e.g., reverse transcriptase), becomes incorporated into the target DNA molecule. Also disclosed herein are various methods that leverage prime editing, including treating trinucleotide repeat contraction diseases, installing targeted peptide tags, treating prion disease through the installation of protection mutations, manipulating RNA-encoding genes for the installation of RNA tags for controlling the function and expression of RNA, using prime editing to construct sophisticated gene libraries, using prime editing to insert immunoepitopes into proteins, use of prime editing to insert inducible dimerization domains into protein targets, and delivery methods, among others. |
| FILED | Monday, May 23, 2022 |
| APPL NO | 17/751599 |
| CURRENT CPC | Peptides C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/1276 (20130101) C12N 15/11 (20130101) Original (OR) Class C12N 15/907 (20130101) C12N 2310/20 (20170501) C12N 2310/3519 (20130101) Enzymes C12Y 207/07049 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230090238 | JERUSIK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ADVANCED RX (FORT WASHINGTON, Pennsylvania) |
| ASSIGNEE(S) | ADVANCED RX (FORT WASHINGTON, Pennsylvania) |
| INVENTOR(S) | Jason Sassan JERUSIK (Plymouth Meeting, Pennsylvania); Kyle Stephen SALATA (Flourtown, Pennsylvania) |
| ABSTRACT | A composition including a poloxamer gel, wherein the poloxamer gel is a combination of poloxamer 407 and poloxamer 188, wherein the composition further include preserved water and wherein the composition does not contain pharmaceutical agents and radioactive compounds. A composition including a poloxamer gel, wherein the poloxamer gel is a combination of poloxamer 407 and poloxamer 188; wherein the composition further includes preserved water; wherein the composition is formed from poloxamer gel components having a mean size of at most 0.5 mm; and wherein the composition is a gel at temperatures ranging from 25.5° C. to 28.9° C. and a solid at temperatures ranging from 30° C. to 36° C. |
| FILED | Friday, September 16, 2022 |
| APPL NO | 17/946556 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/0043 (20130101) A61K 31/765 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230090282 | SPIEGEL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David SPIEGEL (Hamden, Connecticut); David CAIANIELLO (Brooklyn, New York); Emily BRANHAM (Hamden, Connecticut) |
| ABSTRACT | The present disclosure provides, in one aspect, bifunctional compounds that can be used to promote or enhance degradation of certain circulating proteins. In certain embodiments, the circulating protein mediates a disease and/or disorder in a subject, and treatment or management of the disease and/or disorder requires degradation, removal, or reduction in concentration of the circulating protein in the subject. Thus, in certain embodiments, administration of a compound of the disclosure to the subject removes or reduces the circulation concentration of the circulating protein, thus treating, ameliorating, or preventing the disease and/or disorder. |
| FILED | Tuesday, March 15, 2022 |
| APPL NO | 17/654984 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6807 (20170801) A61K 47/6811 (20170801) A61K 47/6889 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230090435 | Lewis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kim Lewis (Newton, Massachusetts); Yu imai (Kobe, Japan); Quentin Favre-Godal (Geneva, Switzerland); Akira Iinishi (Newton, Massachusetts); Kirsten Meyer (Toronto, Canada) |
| ABSTRACT | Embodiments of the present invention relate to a novel compound of Formula (I) or stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, for use in treatment of infection caused by Gram-negative bacteria. |
| FILED | Thursday, November 17, 2022 |
| APPL NO | 18/056346 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 7/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230090450 | Kupper |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas S. Kupper (Belmont, Massachusetts) |
| ABSTRACT | Methods of using T cell frequency (TCFR) in melanoma, e.g., as determined by high throughput DNA sequencing of the TCRB gene, as a predictor of disease progression and survival in patients with primary melanoma, and to select and treat subjects. |
| FILED | Thursday, September 29, 2022 |
| APPL NO | 17/956050 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/156 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2800/52 (20130101) G01N 2800/54 (20130101) G01N 2800/56 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230090487 | Saxon et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); Sixal, Inc. (Santa Monica, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Saxon (Santa Monica, California); Ke Zhang (Los Angeles, California) |
| ABSTRACT | Disclosed herein are anti-IgE antibodies having low binding affinity to human IgE and compositions and methods thereof. |
| FILED | Saturday, October 29, 2022 |
| APPL NO | 18/050993 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/08 (20180101) Peptides C07K 16/4291 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/56 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230090706 | DICKINSON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | The University of Chicago (Chicago, Illinois) |
| INVENTOR(S) | Bryan DICKINSON (Chicago, Illinois); Yang CAO (Chicago, Illinois) |
| ABSTRACT | The current disclosure relates to nucleic acid therapeutics that target mRNA molecules and recruit translation machinery to increase the translation from the mRNA, thus increasing the protein product in a subject or cell. Accordingly, aspects of the disclosure relate to a chimeric nucleic acid comprising a targeting region and a translational activating region, wherein the translational activating region comprises at least one ribosome and/or translation factor binding site and wherein the targeting region comprises a region that is complementary to a target mRNA. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/905116 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/67 (20130101) C12N 15/113 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230090746 | CURTISS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Roy CURTISS (Gainesville, Florida); Amir GHASEMI (Boca Raton, Florida) |
| ABSTRACT | Helicobacter pylori is a leading cause of gastric mucosal inflammation, peptic ulcers, and gastric adenocarcinoma. Emerging antimicrobial-resistant H. pylori has hampered the successful eradication of frequent chronic infections. Additionally, due to the absence of effective vaccines against H. pylori, a safe vaccine is highly demanded. Disclosed herein are innovative Protective Immunity Enhanced Salmonella Vaccine (PIESV) vector strains to deliver and express multiple H. pylori antigen genes Immunization of mice with a vaccine delivering the HpaA, NapA (also termed Hp-NAP), UreA and UreB antigens, provided sterile protection against H. pylori SS1 infection in 7 out of 10 tested mice. Compared to the control groups that had received PBS or a PIESV with an empty vector, immunized mice exhibited specific and significant cellular recall responses and antigen-specific IgG2c, IgG1, total IgG and gastric IgA antibody titers. Importantly, the mice immunized with the vaccine candidate showed a significant reduction in a load of an unidentified Gram-positive rod-shaped bacteria in their stomach compared to the control groups. In conclusion, a Salmonella Typhimurium-based live vaccine delivering four antigens shows promise as a safe and effective vaccine against H. pylori infection. |
| FILED | Monday, February 08, 2021 |
| APPL NO | 17/798181 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/105 (20130101) Original (OR) Class A61K 2039/55594 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 1/36 (20130101) C12N 15/85 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230090771 | FREEMAN |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (MINNEAPOLIS, Minnesota) |
| ASSIGNEE(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (MINNEAPOLIS, Minnesota) |
| INVENTOR(S) | Michael F. FREEMAN (Minneapolis, Minnesota) |
| ABSTRACT | Provided herein are methods and compositions for producing alpha-N-methylated peptides in vitro and in vivo. This disclosure also provides in vivo and in vitro methods for producing highly diverse alpha-N-methylated peptide libraries by methylating natural or non-natural alpha-N-methyltransferase target peptides. |
| FILED | Monday, February 22, 2021 |
| APPL NO | 17/801458 |
| CURRENT CPC | Peptides C07K 14/375 (20130101) Original (OR) Class C07K 2319/21 (20130101) C07K 2319/23 (20130101) C07K 2319/43 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1007 (20130101) C12N 15/70 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230090779 | KING et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington); THE USA,AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Neil P. KING (Seattle, Washington); Daniel ELLIS (Seattle, Washington); Masaru KANEKIYO (Seattle, Washington); Julia LEDERHOFER (Seattle, Washington); Barney S. GRAHAM (Seattle, Washington) |
| ABSTRACT | The disclosure provides non-naturally occurring mutant neuraminidase (NA) polypeptides that improve expression and or modifies the open/closed tetrameric conformational state of the NA polypeptide, and uses thereof. |
| FILED | Thursday, March 04, 2021 |
| APPL NO | 17/904157 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/145 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) Peptides C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/2402 (20130101) Original (OR) Class C12N 2760/16022 (20130101) Enzymes C12Y 302/01018 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230090784 | Miyake et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Colorado State University Research Foundation (Fort Collins, Colorado); New Iridium Inc. (Superior, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Garret M. Miyake (Fort Collins, Colorado); Justin P. Cole (Fort Collins, Colorado); Ryan M. Pearson (Fort Collins, Colorado); Chern-Hooi Lim (Superior, Colorado); Max Kudisch (Fort Collins, Colorado); Dian-Feng Chen (Fort Collins, Colorado) |
| ABSTRACT | The disclosure relates to benzo[ghi]perylene imide photoredox catalysts (PC) and methods for the Birch reductions of aromatic substrates, such as benzene, benzeneoid, and heteroaromatic compounds, using light as the driving force. Certain aspects of the disclosure encompass methods for reduction of aromatic substrates. The method comprises contacting an aromatic substrate with a sacrificial electron donor in the presence of a photoredox catalyst in a solvent, thereby forming a reaction mixture; exposing the reaction mixture to visible or UV light under reaction condition sufficient to reduce the aromatic substrate compound. |
| FILED | Monday, January 11, 2021 |
| APPL NO | 17/790027 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/006 (20130101) B01J 31/0247 (20130101) Original (OR) Class B01J 35/004 (20130101) Heterocyclic Compounds C07D 209/62 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230090966 | Mauldin, Jr. et al. |
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| FUNDED BY |
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| APPLICANT(S) | Rivanna Medical, Inc. (Charlottesville, Virginia) |
| ASSIGNEE(S) | Rivanna Medical, Inc. (Charlottesville, Virginia) |
| INVENTOR(S) | Frank William Mauldin, Jr. (Troy, Virginia); Adam Dixon (Charlottesville, Virginia); Zachary Leonard (Charlottesville, Virginia) |
| ABSTRACT | An ultrasound-based scanning apparatus and system using a dual-array probe and slot for guidance and insertion of a needle to assist with needle injection procedures. |
| FILED | Thursday, September 22, 2022 |
| APPL NO | 17/950399 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/12 (20130101) Original (OR) Class A61B 90/37 (20160201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230091060 | LIU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Conecticut (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Changchun LIU (Farmington, Connecticut); Kun YIN (Farmington, Connecticut) |
| ABSTRACT | Described herein is an aqueous, miscible, multiphase, one-pot detection system including a first phase comprising a low density solution comprising a nucleic acid detection system; and a second phase in diffusive communication with the first phase, the second phase having a higher density than the first phase, and the second phase including a nucleic acid amplification system. Also included are multiwell plates and/or devices including the system and methods of detecting target nucleic acids. |
| FILED | Friday, February 05, 2021 |
| APPL NO | 17/790277 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1241 (20130101) C12N 2310/20 (20170501) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6844 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230091323 | Mikos et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | William Marsh Rice University (Houston, Texas) |
| ASSIGNEE(S) | William Marsh Rice University (Houston, Texas) |
| INVENTOR(S) | Antonios Georgios Mikos (Houston, Texas); Jason Liwei Guo (Houston, Texas); Luis Antonio Diaz-Gomez (Oviedo, Spain); Anthony John Melchiorri (Houston, Texas); Maryam Eugenia Elizondo (Houston, Texas); Gerry Lynn Koons (Houston, Texas); Panayiotis Dimitrios Kontoyiannis (Bellaire, Texas) |
| ABSTRACT | Compositions and methods for making biocompatible articles are provided. A method includes preparing a 3D printable mixture and depositing successive layers of the mixture in a predetermined pattern to form a porous biocompatible article. The predetermined pattern has a porosity suitable for a bone or cartilage scaffold. Associated 3D printable compositions and porous articles made from the described methods are also described. The preparing a 3D printable mixture can comprise conjugating an alkyne-terminated polymer to a peptide to form a peptide-containing composite, or providing a mixture that comprises a ceramic material and a binder, and wherein the 3D printable mixture comprises from 50 wt. % to 80 wt. % of the ceramic material. |
| FILED | Tuesday, February 02, 2021 |
| APPL NO | 17/904266 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/12 (20130101) A61L 27/18 (20130101) Original (OR) Class A61L 27/22 (20130101) A61L 27/56 (20130101) A61L 27/3834 (20130101) A61L 2430/10 (20130101) Shaping Clay or Other Ceramic Compositions; Shaping Slag; Shaping Mixtures Containing Cementitious Material, e.g Plaster B28B 1/001 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/64 (20130101) C04B 35/447 (20130101) C04B 35/6269 (20130101) C04B 35/6346 (20130101) C04B 2235/447 (20130101) C04B 2235/5436 (20130101) C04B 2235/5445 (20130101) C04B 2235/5454 (20130101) C04B 2235/6026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230091690 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| INVENTOR(S) | Feng Zhang (Cambridge, Massachusetts); Guilhem Faure (Cambridge, Massachusetts); Daniel Strebinger (Cambridge, Massachusetts); Makoto Saito (Cambridge, Massachusetts) |
| ABSTRACT | Described herein are guided excision-transposition systems, methods of making, and uses thereof. |
| FILED | Wednesday, December 30, 2020 |
| APPL NO | 17/788781 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/79 (20130101) C12N 15/85 (20130101) C12N 15/102 (20130101) Original (OR) Class C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230091810 | Gangjee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duquesne University of the Holy Spirit (Pittsburgh, Pennsylvania); Wayne State University (Detroit, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aleem Gangjee (Allison Park, Pennsylvania); Larry H. Matherly (Novi, Michigan) |
| ABSTRACT | A compound of the Formula I and optionally a pharmaceutically acceptable salt thereof is provided: Formula I, wherein, R is one selected from the group consisting of H and CH3; n is an integer 4 when X is -CH2- and Ar is 1,4-phenyl, or n is an integer ranging from 1 to 4 when X is -CH2-and Ar is either 2'-fluoro-1,4-phenyl or 2,5-thienyl, or n is an integer ranging from 1 to 4 when X is one selected from the group consisting of O, S, -NH-, -NHCHO-, -NHCOCH3-, and -NHCOCF3- and Ar is one selected from the group consisting of (a) 1,4-phenyl, (b) 2'-fluoro-1,4-phenyl, and (c) 2,5-thienyl, or n is an integer 3 when X is -CH2-, R is CH3 and Ar is 1,4-phenyl. |
| FILED | Monday, June 27, 2022 |
| APPL NO | 17/809181 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 487/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230091847 | Kmiec et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Christiana Care Gene Editing Institute, LLC (Wilmington, Delaware) |
| ASSIGNEE(S) | Christiana Care Gene Editing Institute, LLC (Wilmington, Delaware) |
| INVENTOR(S) | Eric B. Kmiec (Middletown, Delaware); Pawel A. Bialk (Wilmington, Delaware) |
| ABSTRACT | The invention relates to the unexpected discovery of a system and methods for precise homology directed repair after CRISPR/Cas9 cleavage. The invention includes a DNA cleavage and repair system comprising a CRISPR/Cas9 system and an oligonucleotide 100% complementary to cleaved DNA to promote homology directed DNA repair. The invention further includes methods for inducing homology directed repair of cleaved DNA and repairing a CRISPR/Cas9 cleavage. |
| FILED | Wednesday, July 06, 2022 |
| APPL NO | 17/858389 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/90 (20130101) C12N 15/102 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230091848 | Hazen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Cleveland Clinic Foundation (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stanley L. Hazen (Pepper Pike, Ohio); Ina Nemet (Lyndhurst, Ohio); Prasenjit Saha (Cleveland, Ohio) |
| ABSTRACT | The present invention relates to systems, kits, and methods for identifying subjects with increased levels of phenylacetyl glutamine (PAG) or the combination of PAG and trimethylamine-n-oxide (TMAO) and/or N6-trimethyl-lysine (TML), and/or PSA, pp and/or betaine, and/or choline, as well as methods of determining risk of disease (e.g., CVD, heart failure, asthma, diabetes, thrombosis, and lethal prostate cancer) based on such levels. In certain embodiments, the subjects are free of chronic kidney disease and/or have type II diabetes. In particular embodiments, subjects are treated with a therapeutic, such as a beta-adrenergic blocking agent, an alpha 2 adrenergic receptor agonist, an alpha 2 adrenergic receptor antagonist, an antibiotic or antibiotic cocktail, or a prostate cancer therapeutic. In certain embodiments, the subject is treated with a procedure such as brachytherapy, radiation therapy, or prostatectomy. |
| FILED | Thursday, February 04, 2021 |
| APPL NO | 17/795465 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/19 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) G01N 33/5038 (20130101) Original (OR) Class G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230092323 | CHEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BROAD INSTITUTE, INC. (CAMBRIDGE, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (CAMBRIDGE, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (CAMBRIDGE, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fei CHEN (CAMBRIDGE, Massachusetts); Jesse ENGREITZ (CAMBRIDGE, Massachusetts); Jamie MARSHALL (CAMBRIDGE, Massachusetts); Vidya SUBRAMANIAN (CAMBRIDGE, Massachusetts); Sam RODRIQUES (CAMBRIDGE, Massachusetts) |
| ABSTRACT | Provided herein are methods for generating single-cell molecular analysis comprising a) delivering one or more proximity dependent probes to a cell population, wherein each proximity dependent probe comprises a target binding region configured to bind a target RNA and a primer binding site region; b) linking bound proximity dependent probes; c) isolating single cells from the cell population in separate individual discrete volumes, the individual discrete volumes further comprising a primer pair and amplification reagents, wherein the primer pair binds to the primer binding sites of the ligation dependent probes, and wherein at least one primer comprises a barcode sequence that uniquely identifies the individual discrete volume; d) amplifying the ligated probes using the primer pair, wherein the barcode is incorporated into each resulting amplicon; and e) quantifying target RNAs in each individual cell based at least in part on sequencing the resulting amplicons. |
| FILED | Monday, August 15, 2022 |
| APPL NO | 17/819893 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1086 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6874 (20130101) Original (OR) Class C12Q 1/6876 (20130101) C12Q 2600/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230092441 | Gomperts et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brigitte N. Gomperts (Los Angeles, California); Cody J. Aros (Los Angeles, California) |
| ABSTRACT | The present disclosure relates to compositions for use in the treatment of certain disorders (e.g., cancer). The present disclosure also provides methods of treating cancer and/or promoting airway homeostasis. |
| FILED | Monday, October 26, 2020 |
| APPL NO | 17/789044 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/352 (20130101) Original (OR) Class A61K 31/404 (20130101) A61K 31/496 (20130101) A61K 31/5377 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230092817 | Bishai et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William R. Bishai (Baltimore, Maryland); Trinity J. Bivalacqua (Baltimore, Maryland); Alok Singh (Baltimore, Maryland); Monali Praharaj (Baltimore, Maryland); Takahiro Yoshida (Baltimore, Maryland) |
| ABSTRACT | Described are methods of suppressing the expression of myeloid-derived suppressor cells (MDSCs), M2 macrophages, and Treg cells in a tumor and inducing the expression of macrophages, dendritic cells (DCs), and T effector cells in a tumor in a subject. A pharmaceutical composition comprising a strain of Mycobacteria including an expression vector of the present invention is administered to a subject. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/797055 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 38/45 (20130101) A61K 38/1709 (20130101) A61K 39/3955 (20130101) A61K 48/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/4703 (20130101) C07K 14/4705 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1241 (20130101) C12N 15/74 (20130101) Original (OR) Class Enzymes C12Y 207/07 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230092870 | Chesler et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by The Secretary, Dept. of Health and Human Services (Bethesda, Maryland); University of Tennessee Research Foundation (Knoxville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander Theodore Chesler (Bethesda, None); Valeria Vasquez (Germantown, None); Julio Francisco Cordero-Morales (Germantown, None); Luis Octavio Romero (Memphis, None); Kaining Zhi (Memphis, None); Harry Kochat (Piperton, None) |
| ABSTRACT | Described herein is a method of treating pain by administering to a subject in need of treatment for pain a pharmaceutical composition including a therapeutically effective amount of margaric acid. Also described are pharmaceutical compositions such as topical and transdermal compositions including margaric acid and a pharmaceutically acceptable excipient. Further described is a composition for the treatment of pain including margaric acid, eicosapentaenoic acid, and a pharmaceutically acceptable excipient. |
| FILED | Sunday, February 21, 2021 |
| APPL NO | 17/799500 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/20 (20130101) Original (OR) Class A61K 31/557 (20130101) A61K 47/44 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230092885 | EXNER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | AGATA EXNER (Cleveland, Ohio); JAMES BASILION (Cleveland, Ohio); AMIN JAFARI SOJARHOOD (Cleveland, Ohio); AL DELEON (Cleveland, Ohio); RESHANI PERERA (Cleveland, Ohio); MICHAEL KOLIOS (Cleveland, Ohio) |
| ABSTRACT | A method of inducing cell death in a subject includes administering to the subject a plurality of cell targeted nanobubbles that are internalized by the target cell and insonating nanobubbles internalized into the target cell with ultrasound energy effective to promote inertial cavitation of the internalized nanobubbles and apoptosis and/or necrosis of the target cell. |
| FILED | Friday, March 12, 2021 |
| APPL NO | 17/910248 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5123 (20130101) A61K 39/001195 (20180801) A61K 41/0033 (20130101) Original (OR) Class A61K 47/64 (20170801) A61K 47/6925 (20170801) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 37/0092 (20130101) A61M 2037/0007 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 13/08 (20180101) A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230093073 | HUNTER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (MINNEAPOLIS, Minnesota) |
| ASSIGNEE(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (MINNEAPOLIS, Minnesota) |
| INVENTOR(S) | Ryan HUNTER (Minneapolis, Minnesota); Jeffrey FLYNN (Minneapolis, Minnesota); Lydia CAMERON (Minneapolis, Minnesota) |
| ABSTRACT | Provided herein are methods and compositions for community-based screening of polymicrobial infections for the selection and administration of antibiotics and antibiotic combinations for treating infections associated with diseases such as cystic fibrosis, chronic obstructive pulmonary disease, and chronic sinus infections. The methods and compositions of this disclosure are advantageous in the sense that antibiotic effectiveness is assessed with respect to a community of microbes rather than a single microbial population, thus reflecting more accurately the in vivo disease environment and enabling the identification of beneficial antimicrobial therapeutics even when the primary bacterial strain shows antibiotic resistance. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/798666 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50853 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/20 (20130101) C12Q 1/689 (20130101) Original (OR) Class C12Q 1/6851 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230093123 | Wu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Xudong Wu (Cambridge, Massachusetts); Tom A. Rapoport (Cambridge, Massachusetts) |
| ABSTRACT | The technology described herein is directed to structural analysis, particularly of small proteins via cryo-EM. |
| FILED | Thursday, September 08, 2022 |
| APPL NO | 17/930483 |
| CURRENT CPC | Peptides C07K 14/195 (20130101) C07K 14/705 (20130101) C07K 16/465 (20130101) C07K 2299/00 (20130101) C07K 2317/569 (20130101) C07K 2319/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/20 (20130101) Original (OR) Class G01N 33/6845 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230093131 | Malhi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Harmeet Malhi (Rochester, Minnesota); Vijay H. Shah (Rochester, Minnesota); Gregory J. Gores (Rochester, Minnesota); Tejasav Sehrawat (Rochester, Minnesota); Juan Pablo Arab Verdugo (Santiago, Chile) |
| ABSTRACT | This document relates to methods and materials for assessing and/or treating alcohol-associated liver disease (ALD). For example, methods and materials to determine if a mammal has an ALD are provided herein. This document also relates to materials and methods for using one or more ALD treatments to treat a mammal (e.g., a human) identified as having an ALD. |
| FILED | Friday, March 12, 2021 |
| APPL NO | 17/802604 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/92 (20130101) Original (OR) Class G01N 2405/08 (20130101) G01N 2800/52 (20130101) G01N 2800/085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230093161 | Daines |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Daines (Tucson, Arizona) |
| ABSTRACT | The present invention features a method for solubilizing chitin in an aqueous solution by dissolving a sample containing chitin in a basic solution and autoclaving the sample. The present invention also features a method for quantifying the amount of chitin in a sample. Chitin binding proteins are used to quantify the amount of chitin using a modified ELISA assay. Results of the assay may be compared to a control containing known amounts of chitin to quantify the chitin in the sample. |
| FILED | Friday, September 23, 2022 |
| APPL NO | 17/934700 |
| CURRENT CPC | Polysaccharides; Derivatives Thereof C08B 37/0003 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/581 (20130101) Original (OR) Class G01N 2333/42 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230093238 | D'Andrea et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alan D'Andrea (Winchester, Massachusetts); Kah Suan Lim (Boston, Massachusetts) |
| ABSTRACT | The disclosure relates to methods for treating cancers (e.g., cancers having a BRCA1 and/or BRCA2 mutation(s)) by administering to the subject an effective amount of a ubiquitin-specific protease 1 (USP1) inhibitor. |
| FILED | Thursday, July 07, 2022 |
| APPL NO | 17/811282 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/423 (20130101) A61K 31/454 (20130101) A61K 31/506 (20130101) Original (OR) Class A61K 31/713 (20130101) A61K 31/4439 (20130101) A61K 38/45 (20130101) A61K 38/1761 (20130101) A61K 39/3955 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/40 (20130101) C07K 2317/24 (20130101) C07K 2317/54 (20130101) C07K 2317/55 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) C12N 2310/11 (20130101) C12N 2310/14 (20130101) Enzymes C12Y 203/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230093460 | QUIJANO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | Yale University (New Haven, Connecticut) |
| INVENTOR(S) | Elias QUIJANO (Durham, Connecticut); Peter GLAZER (Guilford, Connecticut) |
| ABSTRACT | Compositions and methods of use thereof for delivering nucleic acid cargo into cells are provided. The compositions typically include (a) a 3E10 monoclonal antibody or an antigen binding, cell-penetrating fragment thereof; a monovalent, divalent, or multivalent single chain variable fragment (scFv); or a diabody; or humanized form or variant thereof, and (b) a nucleic acid cargo including, for example, a nucleic acid encoding a polypeptide, a functional nucleic acid, a nucleic acid encoding a functional nucleic acid, or a combination thereof. Elements (a) and (b) are typically non-covalently linked to form a complex. |
| FILED | Tuesday, August 30, 2022 |
| APPL NO | 17/823496 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6807 (20170801) Original (OR) Class A61K 47/6851 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230093471 | Ying Chew et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Emily Ying Chew (Bethesda, Maryland); Zhiyong Lu (Bethesda, Maryland); Tiarnan Daniel Lenaghan Keenan (Bethesda, Maryland); Wai T. Wong (Bethesda, Maryland); Yifan Peng (Bethesda, Maryland); Qingyu Chen (Bethesda, Maryland); Elvira Agrón (Bethesda, Maryland) |
| ABSTRACT | Disclosed herein are systems and methods for predicting risk of late age-related macular degeneration (AMD). The method may include receiving one or more color fundus photograph (CFP) images from both eyes of a patient, classifying each CFP image, and predicting the risk of late AMD by estimating a time to late AMD. Classifying each CFP image may include extract one or more deep features for macular drusen and pigmentary abnormalities in each CFP image, grading the drusen and pigmentary abnormalities and/or detecting the presence of RPD in each CFP image. Predicting the risk of late AMD may include estimating a time to late AMD using a Cox proportional hazard model using the presence of RPD, the one or more deep features, and/or the graded drusen and pigmentary abnormalities. |
| FILED | Thursday, February 18, 2021 |
| APPL NO | 17/904573 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/30041 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/30 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230093487 | CHILIAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NORTHEAST OHIO MEDICAL UNIVERSITY (Rootstown, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William M. CHILIAN (Atwater, Ohio); Vahagn OHANYAN (Hudson, Ohio); Liya YIN (Hudson, Ohio) |
| ABSTRACT | A method for treating or preventing heart failure involving blockage of small blood vessels is described. The method involves administering to a subject in need thereof a therapeutically effective amount of a vasodilator. |
| FILED | Monday, May 09, 2022 |
| APPL NO | 17/739629 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0053 (20130101) A61K 31/353 (20130101) A61K 31/519 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/08 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230093592 | Rodriguez et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California); The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jennifer N. Rodriguez (Lathrop, California); Duncan J. Maitland (College Station, Texas); Thomas S. Wilson (San Leandro, California) |
| ABSTRACT | Polymeric based closed cell foams, such as shape memory polymer foams, contain bubbles. Making these bubbles continuous is called reticulation. Disclosed are embodiments of a device and method to controllably reticulate polymer-based closed cell foams by puncturing the membranes of these polymer-based closed cell foams. |
| FILED | Monday, October 31, 2022 |
| APPL NO | 17/977345 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 31/06 (20130101) A61L 31/146 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 44/5663 (20130101) Original (OR) Class Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2075/00 (20130101) Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 5/18 (20130101) B32B 5/32 (20130101) B32B 2266/08 (20130101) B32B 2266/0278 (20130101) B32B 2535/00 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/73 (20130101) C08G 18/3228 (20130101) C08G 18/3278 (20130101) C08G 18/3284 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 9/38 (20130101) C08J 2205/052 (20130101) C08J 2207/10 (20130101) C08J 2375/04 (20130101) Compositions of Macromolecular Compounds C08L 75/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230093782 | David et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota); KANPRO RESEARCH, INC. (Lawrence, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sunil A. David (Minneapolis, Minnesota); Michael J.H. Brush (Minneapolis, Minnesota); Fei Philip Gao (Lawrence, Kansas) |
| ABSTRACT | This disclosure describes a subunit vaccine for a flavivirus, methods of making the vaccine, and methods of using the vaccine. The flavivirus may include, is a mosquito-borne flavivims, for example, Zika virus (ZIKV), dengue virus (DENV), Yellow Fever (YF) virus, and West Nile Virus (WNV). The subunit vaccine may be administered with an adjuvant. |
| FILED | Thursday, December 12, 2019 |
| APPL NO | 17/312534 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class A61K 2039/55511 (20130101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20230085706 | Friesen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin); University of New South Wales (Kensington, Australia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark G. Friesen (Middleton, Wisconsin); Merritt Losert (Madison, Wisconsin); Susan Nan Coppersmith (Redfern, NSW, Australia) |
| ABSTRACT | Gate-controlled quantum dots based on silicon-germanium (SiGe) alloy heterostructures are provided. Also provided are quantum computing systems incorporating the gate-controlled quantum dots. The quantum dots are formed in a semiconductor heterostructure in which a SiGe alloy quantum well is sandwiched between SiGe alloy barriers or between Ge barriers. The presence of germanium in the quantum dots increases the average valley splitting for quantum dots confined in the SiGe. As a result, the yield of quantum dots having a sufficiently high valley splitting for device applications is increased by the use of a SiGe alloy in the quantum well. |
| FILED | Friday, June 17, 2022 |
| APPL NO | 17/842988 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/028 (20130101) H01L 31/035218 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230085711 | Glassman |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BAE Syetems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin S. Glassman (Nashua, New Hampshire) |
| ABSTRACT | A classifier network has at least two distinct sets of refined data, wherein the first two sets of refined data are sets of numbers representing the features values data received from sensors or a manufactured part. Performing, via at least two distinct types of support vector machines using an associated feature selection process for each classifier independently in a first layer, anomaly detection on the manufactured part. Then, using the stored data including refined data of at least two different types of data transforms and performing, via at least a two distinct types of support vector machines in a second layer, an associated feature selection process for each classifier independently. Forming at least four distinct compound classifier types for anomaly detection on the part using the stored data or coefficients. The ensemble of second layer support vector machine outputs compare the results to determine the presence of an anomaly. |
| FILED | Tuesday, November 15, 2022 |
| APPL NO | 17/986982 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6228 (20130101) G06K 9/6232 (20130101) G06K 9/6262 (20130101) G06K 9/6269 (20130101) Original (OR) Class G06K 9/6289 (20130101) Computer Systems Based on Specific Computational Models G06N 20/10 (20190101) G06N 20/20 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230085829 | KURTOGLU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Deniz KURTOGLU (TAMPA, Florida); Tansel YUCELEN (TAMPA, Florida); Stefan RISTEUSKI (TAMPA, Florida); Jonathan MUSE (Beavercreek, Ohio) |
| ABSTRACT | Methods and systems for information exchange of a vehicle in a multiagent system are disclosed. The methods and systems include: receiving one or more neighboring states broadcast by one or more neighboring vehicles; transmitting a last broadcast state of the vehicle to the one or more neighboring vehicles; determining a current state of the vehicle based on the one or more neighboring states and the last broadcast state; determining a norm-free information exchange triggering condition based on the last broadcast state, the current state, and an estimated command; and in response to the current state violating the norm-free information exchange triggering condition, transmitting the current state to the one or more neighboring vehicles. Other aspects, embodiments, and features are also claimed and described. |
| FILED | Monday, September 19, 2022 |
| APPL NO | 17/948160 |
| CURRENT CPC | Wireless Communication Networks H04W 4/46 (20180201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230085867 | Rakin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents of behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adnan Siraj Rakin (Tempe, Arizona); Deliang Fan (Tempe, Arizona); Sai Kiran Cherupally (Tempe, Arizona); Jae-sun Seo (Tempe, Arizona) |
| ABSTRACT | Method, systems, and devices, disclosed herein can leverage noise and aggressive quantization of in-memory computing (IMC) to provide robust deep neural network (DNN) hardware against adversarial input and weight attacks. IMC substantially improves the energy efficiency of DNN hardware by activating many rows together and performing analog computing. The noisy analog IMC induces some amount of accuracy drop in hardware acceleration, which is generally considered as a negative effect. However, this disclosure demonstrates that such hardware intrinsic noise can, on the contrary, play a positive role in enhancing adversarial robustness. To achieve this, a new DNN training scheme is proposed that integrates measured IMC hardware noise and aggressive partial sum quantization at the IMC crossbar. It is shown that this effectively improves the robustness of IMC DNN hardware against both adversarial input and weight attacks. |
| FILED | Tuesday, September 13, 2022 |
| APPL NO | 17/931682 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/64 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/063 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230085919 | Forte et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Domenic J. Forte (Gainesville, Florida); Nima Maghari (Gainesville, Florida); Michael Levin (Gainesville, Florida); Sreeja Chowdhury (Gainesville, Florida) |
| ABSTRACT | A method and system are directed to designing a low-dropout regulator (LDO) circuit and using the LDO circuit to detect recycled counterfeit integrated circuits. The LDO circuit includes, in part, a reference path circuit and a stressed path circuit. Each of the reference path circuit and the stressed path circuit is coupled to a control signal that can enable the corresponding path circuit for the LDO. LDO parameters can then be measured while the reference path circuit and the stressed path circuit is enabled respectively. The difference between the LDO parameters measured while the reference path circuit is enabled and while the stressed path circuit is enabled is used to determine if an integrated circuit comprising the LDO circuit is a recycled counterfeit. |
| FILED | Wednesday, June 22, 2022 |
| APPL NO | 17/808185 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/2851 (20130101) Systems for Regulating Electric or Magnetic Variables G05F 1/56 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230086183 | Dilger et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Jonathan M. Dilger (Bloomington, Indiana); Benjamin P. Wilkins (Jasper, Indiana); Kelly M. Thoreson (Bloomington, Indiana); Brian C. Bohrer (Evansville, Indiana) |
| ABSTRACT | Provided is a method to initiate and analyze chemical derivatives formed from pyrotechnic smoke reactions. Milligram quantities of a lab-scale pyrotechnic smoke composition are reacted by encapsulation with a metal probe that is rapidly heated, which then sublimes the organic dye, allowing for the testing of all of the gas-phase products for identification by pyrolysis-gas chromatography-mass spectrometry. The thermally decomposed ingredients and new side product derivatives are identified at lower relative abundances compared to the intact organic dye. Any remaining residues within the thermal probe are optionally reconstituted into solution for further analysis by liquid chromatography-mass spectrometry if desired. The results are processed via a machine learning quantitative structure-activity relationship model that provides data related to health and environmental hazards. |
| FILED | Wednesday, September 21, 2022 |
| APPL NO | 17/949586 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/7233 (20130101) Original (OR) Class G01N 30/8631 (20130101) G01N 30/8644 (20130101) G01N 30/8668 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230086359 | PARAKININKAS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Terumo BCT Biotechnologies, LLC (Lakewood, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kestas P. PARAKININKAS (Englewood, Colorado); Eric T. HANSEN (Thornton, Colorado); Kirk L. WEIMER (Green Valley, Arizona); Nathaniel T. JOHNSON (Highlands Ranch, Colorado); Dennis J. HLAVINKA (Arvada, Colorado) |
| ABSTRACT | Provided is a multi-part lyophilization container for lyophilizing a fluid, storing the lyophilizate, reconstituting the lyophilizate, and infusing the reconstituted lyophilizate into a patient, including a method of using same. The container includes a front surface, a back surface, a non-breathable section including a port region, a breathable section including a breathable membrane, and a peelable region including a peelable seal encompassing a boundary between the non-breathable section and the breathable section. The method includes inputting a fluid into a non-breathable section of the container, freezing the fluid, applying, in a lyophilization chamber, vacuum pressure, opening the peelable seal using a pressure differential, applying heat energy, sublimating the fluid and creating a temporary occlusion in a peelable region of the container. |
| FILED | Monday, November 28, 2022 |
| APPL NO | 18/070085 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0263 (20130101) A01N 1/0284 (20130101) A01N 1/0289 (20130101) Containers Specially Adapted for Medical or Pharmaceutical Purposes; Devices or Methods Specially Adapted for Bringing Pharmaceutical Products into Particular Physical or Administering Forms; Devices for Administering Food or Medicines Orally; Baby Comforters; Devices for Receiving Spittle A61J 1/10 (20130101) A61J 1/1468 (20150501) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/0277 (20140204) A61M 2202/0415 (20130101) A61M 2205/584 (20130101) A61M 2205/3389 (20130101) Drying Solid Materials or Objects by Removing Liquid Therefrom F26B 5/06 (20130101) Original (OR) Class F26B 21/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230086475 | Mosko |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Palo Alto Research Center Incorporated (Palo Alto, California) |
| ASSIGNEE(S) | Palo Alto Research Center Incorporated (Palo Alto, California) |
| INVENTOR(S) | Marc E. Mosko (Kensington, California) |
| ABSTRACT | A system and method are provided to facilitate securing windows discretionary access control. During operation, the system determines a Windows domain model including: user-specified desired effective permissions as capability assignments of principals on resources, wherein a respective capability assignment comprises a permission of a respective principal to a respective resource and wherein a respective principal comprises a user or a group of users; and user-specified policies and rules for relationships between principals, groups, and resources. The system creates a domain graph and an access control graph based on the Windows domain model. The domain graph maps paths between nodes representing users, groups, and resources based on the policies and rules. The access control graph allows for calculation of actual permissions of principals on resources based on the desired effective permissions. The system determines a set of optimal policy-conformant configurations based on the domain graph and the access control graph. |
| FILED | Wednesday, August 31, 2022 |
| APPL NO | 17/900774 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 63/20 (20130101) Original (OR) Class H04L 63/104 (20130101) H04L 63/105 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230086715 | Usenko |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alexander Usenko (Lake St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander Usenko (Lake St. Louis, Missouri) |
| ABSTRACT | Process flow for a stacked power diode and design of the resulting diode is disclosed. Blanket epitaxy over heavy doped wafers is performed. By controlling dopant addition during epitaxy, desired n-type, diode base, and p-type doping profiles and thicknesses achieved. V-groove pattern if formed on wafers by depositing mask film, lithography and anisotropic etch. Islands surrounded by V-grooves define individual diodes. V-grooves serve as side insulation. Next, oxidation step passivates V-grooves. Further, the mask film is stripped to open diode contact areas on both sides of wafers. Next high melting point metal and low melting point metal films are selectively electroplated on all open silicon surfaces. Stacking is performed on wafer level by bonding of desired wafer count by solid-liquid interdiffusion process. Wafer stacks are sawed into individual stacked diode dies along outer slopes of V-grooves. Final stacked devices can be used as DSRD—drift step recovery diodes. Compared to DSRDs made by known methods, better fabrication yield and higher pulse power electrical performance is achieved. |
| FILED | Thursday, September 15, 2022 |
| APPL NO | 17/946022 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/8613 (20130101) Original (OR) Class H01L 29/66121 (20130101) H01L 29/66136 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230087209 | Holt et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brendon R. Holt (Tucson, Arizona); Gerald P. Uyeno (Tucson, Arizona); Vanessa Reyna (Tucson, Arizona); Olga Vargas (Tucson, Arizona); Jordan Sawyer (Marana, Arizona); Brayden Peery (Vail, Arizona) |
| ABSTRACT | Thermal control of powered systems on-board a flight vehicle is achieved by leveraging the latent heat storage capacity of Phase Change Materials (PCMs) to maintain the operating temperature at or slightly above the melting temperature of the PCM. The invention is particularly well suited for use with powered systems such as laser, microwave emitters, RF sensors and high-density power electronics that must operate at a desired operating temperature while generating considerable waste heat in a confined packaging volume of smaller flight vehicles such as missiles, rockets, guided projectiles, drones or other such platforms. |
| FILED | Friday, September 17, 2021 |
| APPL NO | 17/478440 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/002 (20130101) B64G 1/50 (20130101) Original (OR) Class B64G 1/58 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230087465 | Ziehl et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of South Carolina (Columbia, South Carolina) |
| ASSIGNEE(S) | University of South Carolina (Columbia, South Carolina) |
| INVENTOR(S) | Paul Ziehl (Irmo, South Carolina); Vafa Soltangharaei (Columbia, South Carolina) |
| ABSTRACT | Described herein are systems and methods based on acoustic emission (AE) technology to monitor a concrete structure for a short interval and, based on signals acquired, estimate Alkali-silica reaction (ASR) progression status in the structure remotely and efficiently without halting any serviceability and operational activities of the structure, knowing the ASR progression status of the structure helps determine rehabilitation and future structural safety and serviceability of the structure. |
| FILED | Friday, July 08, 2022 |
| APPL NO | 17/860171 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/12 (20130101) G01N 29/14 (20130101) G01N 29/0654 (20130101) Original (OR) Class G01N 33/383 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230087883 | Kosai et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hiroyuki Kosai (Beavercreek, Ohio); James D. Scofield (Whittier, North Carolina); Tyler W Bixel (Beavercreek, Ohio) |
| ABSTRACT | The present invention relates high power AC steering flux cancelling inductors and processes of making and using same. When properly configured and wired such inductors, separate the AC component and DC component of a high power current thus allowing the smaller AC fraction of the overall current to be carried by much smaller cross-sectional litz wires. Such high power AC steering flux cancelling inductors are more efficient at avoiding core saturation compared to standard inductors, yet they are less expensive without the need for large cross-sectional litz AC carrying wires. In addition to the aforementioned benefits, such high power AC steering flux cancelling inductor permits the levels of AC and DC current to be efficiently monitored as such currents are separated. |
| FILED | Wednesday, September 07, 2022 |
| APPL NO | 17/939070 |
| CURRENT CPC | Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 27/24 (20130101) Original (OR) Class H01F 27/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230087994 | Spiegel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Spiegel (New Haven, Connecticut); David Caianiello (Brooklyn, New York); Jake Swartzel (New Haven, Connecticut) |
| ABSTRACT | The present disclosure provides, in one aspect, bifunctional compounds that can be used to promote or enhance degradation of certain circulating proteins. In another aspect, the present disclosure provides bifunctional compounds that can be used to promote or enhance degradation of certain autoantibodies. In certain embodiments, treatment or management of a disease and/or disorder requires degradation, removal, or reduction in concentration of the circulating protein or the autoantibody in the subject. Thus, in certain embodiments, administration of a compound of the disclosure to the subject removes or reduces the circulation concentration of the circulating protein or the autoantibody, thus treating, ameliorating, or preventing the disease and/or disorder. In certain embodiments, the circulating protein is TNF. |
| FILED | Tuesday, March 15, 2022 |
| APPL NO | 17/654990 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/55 (20170801) Original (OR) Class A61K 47/58 (20170801) A61K 47/60 (20170801) A61K 47/545 (20170801) A61K 47/548 (20170801) A61K 47/549 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230088777 | Sample et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America as Represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dwane F. Sample (San Diego, California); Carl E. Lostrom (San Diego, California) |
| ABSTRACT | A flow battery comprising: a first tank having a variable internal volume and containing a first ionic solution having a first oxidation state, and wherein the first tank is substantially evacuated of any gas; a second tank having a variable internal volume and containing a second ionic solution having a second oxidation state that is different from the first oxidation state, and wherein the second tank is substantially evacuated of any gas; a reaction chamber operatively coupled with the first and second tanks such that the first ionic solution within the reaction chamber is separated from the second ionic solution by an ion exchange membrane; a first pump configured to pump the first ionic solution through the reaction chamber; and a second pump configured to pump the second ionic solution through the reaction chamber. |
| FILED | Thursday, September 23, 2021 |
| APPL NO | 17/483503 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/188 (20130101) Original (OR) Class H01M 8/0273 (20130101) H01M 8/04276 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230088835 | Mirkin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chad A. Mirkin (Wilmette, Illinois); Sasha B. Ebrahimi (DeKalb, Illinois); Devleena Samanta (Evanston, Illinois) |
| ABSTRACT | The present disclosure is directed to spherical nucleic acids (SNAs) comprising a nanoparticle core and an oligonucleotide, use of the SNAs to, e.g., detect target analytes, and methods of making the SNAs. In various embodiments, the target analyte is detected using the nanoparticle core, the oligonucleotide, or both. In some embodiments, the oligonucleotide comprises a detectable marker situated at an internal location within the oligonucleotide. In some aspects, the disclosure provides methods for detecting a target analyte comprising the step of contacting the target analyte with a spherical nucleic acid (SNA) and an agent, the SNA comprising a protein core and an oligonucleotide attached thereto, wherein the contacting of the protein core with the target analyte results in a change in the target analyte that is detectable by the agent, thereby detecting the target analyte. |
| FILED | Monday, July 20, 2020 |
| APPL NO | 17/908809 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/535 (20130101) G01N 33/5308 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230088979 | Neogi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Reg. of the Univ. of CO, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sanghamitra Neogi (Boulder, Colorado); Artem Konstantinovich Pimachev (Boulder, Colorado) |
| ABSTRACT | A method for determining electronic band structure includes partitioning, based on a location of each of a plurality of atoms forming a crystalline structure, a volume of the crystalline structure to obtain Voronoi tessellations. The method also includes constructing, based on the Voronoi tessellations, a plurality of crystal graphs and deriving, based on the plurality of crystal graphs, one or more local structural features of the crystalline structure. The method also includes feeding, into a trained machine-learning model, the one or more local structural features, one or more global structural features of the crystalline structure, and one or more species-based features of the crystalline structure. The trained machine-learning model, in response to said feeding, returns a plurality of energy values that sample a Brillouin zone of the crystalline structure. |
| FILED | Thursday, September 08, 2022 |
| APPL NO | 17/930619 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/2648 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230089278 | Kishore Kumar, Ph.d et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Deepan Kishore Kumar, Ph.d (Pasadena, California); Nai-Chang Yeh (Pasadena, California) |
| ABSTRACT | Described are devices, such as light emitters, lasers, and switches, and methods, such as methods of generating photoluminescence and methods of fabricating electronic devices. Example devices and methods described include those comprising or employing optically active graphene, such as in the form of one or more layers of quasi-1D graphene nanomaterials or graphene nanostripes including one or more topological defects. Optically active graphene can emit photoluminescence upon exposure to photoexcitation and can also generate laser emission, optionally as a frequency comb. The optically active graphene can be patterned onto substrates according to the disclosed methods of fabricating electronic devices and is optionally useful for generating optical switches. |
| FILED | Thursday, September 22, 2022 |
| APPL NO | 17/950421 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 15/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/19 (20170801) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/65 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230089475 | Uyar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States Government, as represented by the Secretary of the Army (Aberdeen Proving Ground, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Muharrem Umit Uyar (Holmdel, New Jersey); Janusz Kusyk (Kew Gardens, New York); Jeffrey Boksiner (Cockeysville, Maryland); Giorgio Bertoli (Bel Air, Maryland); Sagor Hoque (New Castle, Delaware); Joseph Plishka (Stewartstown, Pennsylvania) |
| ABSTRACT | A method that pertains to location of an emitter source is provided. The method can use game theory and an estimation method. A non-transitory computer-readable storage medium configured to store a program that implements the method is provided. A system comprising a swarm of autonomous entities and a control unit that can implement the method is provided. |
| FILED | Monday, September 19, 2022 |
| APPL NO | 17/947685 |
| CURRENT CPC | Systems for Controlling or Regulating Non-electric Variables G05D 1/0027 (20130101) Computer Systems Based on Specific Computational Models G06N 3/126 (20130101) Transmission H04B 17/318 (20150115) Wireless Communication Networks H04W 4/021 (20130101) Original (OR) Class H04W 4/023 (20130101) H04W 4/40 (20180201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230089714 | Razeghi |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Manijeh Razeghi (Wilmette, Illinois) |
| ABSTRACT | High electron mobility transistors are provided which comprise a III-Nitride semiconductor layer comprising a III-Nitride semiconductor, in contact with a gallium oxide semiconductor layer comprising gallium oxide, forming an interface therebetween. |
| FILED | Wednesday, September 07, 2022 |
| APPL NO | 17/939048 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/2003 (20130101) H01L 29/7786 (20130101) H01L 29/66462 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230089871 | MCCLUNG et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Holly MCCLUNG (Westborough, Massachusetts); Reed Wasson HOYT (Cambridge, Massachusetts); Lawrence M. Candell (Arlington, Massachusetts); Joseph M. MAHAN (Beverly, Massachusetts); Gary A. Shaw (Westford, Massachusetts); Andrew M Siegel (Arlington, Massachusetts); Robert Linton STANDLEY (Acton, Massachusetts); Kyle THOMPSON (Boulder, Colorado) |
| ABSTRACT | A conventional flow tube for a metabolic cart is usually a straight length of pipe whose inner diameter is fixed by the respiratory burden imposed by the flow tube on the user, with a smaller diameter imposing a higher respiratory burden. The ratio of the straight flow tube's length to diameter is fixed by fluid dynamics, so increasing the flow tube's diameter causes the flow tube's length to increase. As the flow tube gets longer, it exerts more torque on the user's neck and jaw, creating discomfort. Reducing the flow tube's length causes an undesired increase in the respiratory burden but increasing the flow tube's diameter to reduce the respiratory burden makes the flow tube less comfortable, making the flow tube unconformable, hard to breathe through, or both. Bending the flow tube makes it possible to increase the flow tube's propagation length without increasing the flow tube's lever arm length. |
| FILED | Thursday, August 11, 2022 |
| APPL NO | 17/819054 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/087 (20130101) A61B 5/097 (20130101) Original (OR) Class A61B 5/0833 (20130101) A61B 5/0836 (20130101) A61B 2562/06 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 16/0808 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230090064 | Shivaram |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Krishna Shivaram (Torrance, California) |
| ABSTRACT | An apparatus includes a current-based temperature compensation circuit having a reference buffer, a biasing current mirror, and a controller. The reference buffer is configured to receive a biasing reference voltage at a voltage input terminal and replicate the biasing reference voltage to first and second buffer terminals. At least one of the first and second buffer terminals is configured to be electrically connected to at least one gate terminal of an analog complementary metal oxide semiconductor (CMOS) physically unclonable function (PUF) cell. The biasing current mirror is configured to receive a reference current at a current input terminal and replicate the reference current to the first buffer terminal. The controller is configured to compensate an output of the CMOS PUF cell for temperature variation based on a weighted sum of a bandgap current, a current proportional to absolute temperature, and a current complementary to absolute temperature. |
| FILED | Friday, September 17, 2021 |
| APPL NO | 17/478718 |
| CURRENT CPC | Pulse Technique H03K 17/145 (20130101) Original (OR) Class H03K 17/0822 (20130101) H03K 2017/0806 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230090214 | Kosai et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hiroyuki Kosai (Beavercreek, Ohio); James D. Scofield (Whittier, North Carolina); Tyler W. Bixel (Beavercreek, Ohio) |
| ABSTRACT | The present invention relates high power stacked flux cancelling inductors and processes of making and using same. When properly configured and wired, such inductors separate the AC component and DC component of a high power current thus allowing the smaller AC fraction of the overall current to be carried by much smaller cross-sectional litz wires. Such high power stacked flux cancelling inductors are more efficient at avoiding core saturation compared to standard inductors, yet they are less expensive without the need for large cross-sectional litz AC carrying wires. In addition to the aforementioned benefits, such high power stacked flux cancelling inductor permits the levels of AC and DC current to be efficiently monitored as such currents are separated. |
| FILED | Wednesday, September 07, 2022 |
| APPL NO | 17/939058 |
| CURRENT CPC | Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 3/14 (20130101) H01F 27/34 (20130101) Original (OR) Class H01F 27/306 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230090724 | Tassev |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vladimir Tassev (Beavercreek, Ohio) |
| ABSTRACT | A method of performing HVPE heteroepitaxy comprises exposing a substrate to a carrier gas, a first precursor gas, a Group II/III element, and ternary-forming gasses (V/VI group precursor), to form a heteroepitaxial growth of a binary, ternary, and/or quaternary compound on the substrate; wherein the carrier gas is Hz, wherein the first precursor gas is HCl, the Group II/III element comprises at least one of Zn, Cd, Hg, Al, Ga, and In; and wherein the ternary-forming gasses comprise at least two or more of AsH3 (arsine), PH3 (phosphine), H2Se (hydrogen selenide), H2Te (hydrogen telluride), SbH3 (hydrogen antimonide, or antimony tri-hydride, or stibine), H2S (hydrogen sulfide), NH3 (ammonia), and HF (hydrogen fluoride); flowing the carrier gas over the Group II/III element; exposing the substrate to the ternary-forming gasses in a predetermined ratio of first ternary-forming gas to second ternary-forming gas (1tf:2tf ratio); and changing the 1tf:2tf ratio over time. |
| FILED | Monday, October 17, 2022 |
| APPL NO | 18/046945 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/024 (20130101) H01L 21/02387 (20130101) H01L 21/02538 (20130101) H01L 21/02551 (20130101) H01L 21/02568 (20130101) H01L 21/02658 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230090772 | Juretus et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Drexel University (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | Drexel University (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Kyle Joseph Juretus (Quakertown, Pennsylvania); Ioannis Savidis (Wallingford, Pennsylvania) |
| ABSTRACT | A proposed technique allows for the security of the logic cone through logic locking and secures the outputs of the circuit from the scan chain without modifications to the structure of the scan chain. Since the oracle responses in test mode do not correspond to the functional key, satisfiability (SAT) attacks are not able to leverage the responses from the scan chain. In addition, a charge accumulation circuit is developed to prevent and detect any attempt to enter the partitioned test mode while the correct circuit responses are still stored within the registers. |
| FILED | Tuesday, September 21, 2021 |
| APPL NO | 17/480771 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/556 (20130101) Original (OR) Class G06F 2221/034 (20130101) Pulse Technique H03K 19/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230090935 | Garren |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Alan Garren (Clifton, Virgin Islands) |
| ABSTRACT | The invention relates to a communication device radiating a purely dipole structure. The communication device includes a metallic sphere having a central axis and electrical wiring wound azimuthally around the central axis of the metallic sphere so that an electric current density of the electric wiring is proportional to a sine of a spherical elevation angle of the metallic sphere. |
| FILED | Friday, July 15, 2022 |
| APPL NO | 17/865884 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 7/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230091072 | Sharp et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Etegent Technologies Ltd. (Cincinnati, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas D. Sharp (Terrace Park, Ohio); Richard A. Roth, II (Goshen, Ohio); Uriah M. Liggett (Independence, Kentucky); Joseph M. Kesler (Cincinnati, Ohio) |
| ABSTRACT | Methods manage non-destructive evaluation (“NDE”) data. NDE data for an asset is received and at least one alignment algorithm to align the NDE data to a simulated model associated therewith is determined. The NDE data is automatically aligned to the simulated model, a display representation that visually represents the aligned NDE data on the simulated model is generated, and information about the aligned NDE data is exported. Additionally, second NDE data associated with the at least a portion of the asset may also be received, at least one alignment algorithm to align the data determined, and the second NDE data aligned. Respective indications associated with the first and second NDE data may be determined and visually represented on the simulated model. Moreover, a shot descriptor file may be analyzed to determine whether additional NDE data is required to complete an alignment of NDE data. |
| FILED | Wednesday, November 23, 2022 |
| APPL NO | 18/058586 |
| CURRENT CPC | Electric Digital Data Processing G06F 17/10 (20130101) Original (OR) Class Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/04 (20130101) G06Q 10/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230091263 | Bixel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tyler W. Bixel (Beavercreek, Ohio); Hiroyuki Kosai (Beavercreek, Ohio); James D. Scofield (Whittier, North Carolina) |
| ABSTRACT | The present invention relates high power AC steering flux cancelling inductors and processes of making and using same. When properly configured and wired such inductors, separate the AC component and DC component of a high power current thus allowing the smaller AC fraction of the overall current to be carried by much smaller cross-sectional litz wires. Such high power AC steering flux cancelling inductors are more efficient at avoiding core saturation compared to standard inductors, yet they are less expensive without the need for large cross-sectional litz AC carrying wires. In addition to the aforementioned benefits, such high power AC steering flux cancelling inductor permits the levels of AC and DC current to be efficiently monitored as such currents are separated. |
| FILED | Wednesday, September 07, 2022 |
| APPL NO | 17/939077 |
| CURRENT CPC | Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 1/12 (20130101) H01F 27/24 (20130101) H01F 27/306 (20130101) Original (OR) Class H01F 27/2823 (20130101) H01F 41/071 (20160101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230091268 | Sinha et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Combustion Research and Flow Technology, Inc. (Pipersville, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Neeraj Sinha (Ivyland, Pennsylvania); Stephen M. Barr (Hellertown, Pennsylvania); Michael R. O'Gara (Sellersville, Pennsylvania) |
| ABSTRACT | An inlet duct for use with an engine is presented. The invention includes a duct structure, at least one spike disposed along an interior surface of the duct structure, and an inlet throat formed by one or more apexes disposed along an equal number of spikes. The inlet throat corresponds to the minimum cross-sectional area through which airflow passes as otherwise allowed by the maximal obstruction formed by the apex(es) within the duct structure. Each spike is bounded by a longitudinal ridge and a lateral ridge along an upper end and a base along a lower end. The longitudinal ridge and the lateral ridge intersect at the apex. In preferred embodiments, the longitudinal ridge is at least partially non-linear so as to properly conform to the interior surface of the duct structure. The portion of each spike upstream of the inlet throat functions primarily as a supersonic diffuser. The portion of each spike downstream of the inlet throat functions primarily as a subsonic diffuser. Airflow is isentropically compressed and then expanded within the inlet duct so that greater-than-subsonic flow at an input end is reduced to subsonic flow at an output end. |
| FILED | Friday, July 08, 2022 |
| APPL NO | 17/860157 |
| CURRENT CPC | Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 33/02 (20130101) B64D 2033/026 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/04 (20130101) Jet-propulsion Plants F02K 7/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
20230091494 — METAL-CARBON-NANOTUBE METAL MATRIX COMPOSITES FOR METAL CONTACTS ON PHOTOVOLTAIC CELLS
| US 20230091494 | Han et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico) |
| ASSIGNEE(S) | UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico) |
| INVENTOR(S) | Sang M. Han (Albuquerque, New Mexico); Omar Abudayyeh (Albuquerque, New Mexico); David Wilt (Albuquerque, New Mexico); Nathan Gapp (Albuquerque, New Mexico) |
| ABSTRACT | A solar cell structure is disclosed that includes a first metal layer, formed over predefined portions of a sun-exposed major surface of a semiconductor structure, that form electrical gridlines of the solar cell; a network of carbon nanotubes formed over the first metal layer; and a second metal layer formed onto the network of carbon nanotubes, wherein the second metal layer infiltrates the network of carbon nanotubes to connect with the first metal layer to form a first metal matrix composite comprising a metal matrix and a carbon nanotube reinforcement, wherein the second metal layer is an electrically conductive layer in which the carbon nanotube reinforcement is embedded in and bonded to the metal matrix, and the first metal matrix composite provides enhanced mechanical support as well as enhanced or equal electrical conductivity for the electrical contacts against applied mechanical stressors to the electrical contacts. |
| FILED | Monday, June 27, 2022 |
| APPL NO | 17/850045 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/158 (20170801) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/073 (20130101) H01L 31/0201 (20130101) H01L 31/022425 (20130101) H01L 51/444 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230091507 | Nag et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Okhil K. Nag (Brandywine, Maryland); Megan E. Muroski (Milwaukee, Wisconsin); Michael H. Stewart (Springfield, Virginia); Alexander Efros (Annandale, Virginia); Scott Walper (Springfield, Virginia); James Delehanty (Washington, Washington); Eunkeu Oh (Alexandria, Virginia) |
| ABSTRACT | A quantum dot (QD)-rhodopsin bioconjugate system uses Förster resonance energy transfer (FRET)-mediated induction of cellular membrane depolarization via optical activation of ion channel proteins channelrhodopsin (ChR). |
| FILED | Friday, September 16, 2022 |
| APPL NO | 17/932995 |
| CURRENT CPC | Peptides C07K 14/405 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 13/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230091655 | FERRELLI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Aerospace Corporation (El Segundo, California) |
| ASSIGNEE(S) | The Aerospace Corporation (El Segundo, California) |
| INVENTOR(S) | Geena L. FERRELLI (Marina Del Rey, California); Hyun I. KIM (Brea, California); Rafael J. ZALDIVAR (Redondo Beach, California) |
| ABSTRACT | Processes for rapidly and accurately measuring the coefficient of moisture expansion for materials, such as adhesives, are disclosed. A replication technique may be used to manufacture highly flat and smooth adhesive samples. Moisture is introduced in a controlled humidity atmosphere, distortion is monitored with an accurate laser interferometer (e.g., ˜1 nanometer (nm) accuracy), and measurements are correlated with moisture content change. Such processes decrease sample size by three orders of magnitude as compared with conventional techniques and have a smaller adhesive mass requirement, which enables measurement of expensive microelectronic adhesives that were previously cost-prohibitive to measure. Also, thinner films allow CME measurements of ultraviolet (UV) cured adhesives that would otherwise have depth of penetration issues. Furthermore, saturation occurs quickly, allowing pre-stabilization at room temperature, which enabled parametric studies as a function of processing or cure state. Additionally, testing occurs within hours versus months, enabling short lead times for root-cause investigations. |
| FILED | Tuesday, September 21, 2021 |
| APPL NO | 17/481184 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 11/24 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/8422 (20130101) Image Data Processing or Generation, in General G06T 7/001 (20130101) G06T 7/64 (20170101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230092602 | Swain et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Florida Institute of Technology, Inc. (Melbourne, Florida) |
| ASSIGNEE(S) | Florida Institute of Technology, Inc. (Melbourne, Florida) |
| INVENTOR(S) | Geoffrey Swain (Melbourne, Florida); Michael Harper (Ponte Vedra, Florida); Melissa Tribou (Satellite Beach, Florida); Harrison Arthur Gardner (Palm Bay, Florida); Caglar Erdogan (Melbourne, Florida) |
| ABSTRACT | A rotating grooming brush comprising a brush hub having grooming elements and shroud elements, and method for grooming a surface having an unwanted material thereon. The elements extend from the brush hub and may be positioned near its outer periphery. The elements may be grooming elements forming an array and shroud elements forming a shroud array. A rigid or elastomeric shroud extending from the brush hub surface may optionally be included about the edge of the brush hub, to the outside of the grooming elements. Rotation of the grooming attachment brush causes a low pressure region to build in the central area of the brush. This low pressure region creates a resulting force that forcefully attracts the grooming attachment brush to the surface to be groomed. The resulting force is controlled by the diameter of the brush hub, arrangement, of the elements and the speed of rotation. |
| FILED | Monday, September 19, 2022 |
| APPL NO | 17/947485 |
| CURRENT CPC | Brushes A46B 9/02 (20130101) Original (OR) Class A46B 13/008 (20130101) Cleaning in General; Prevention of Fouling in General B08B 1/002 (20130101) B08B 1/04 (20130101) Ships or Other Waterborne Vessels; Equipment for Shipping B63B 59/06 (20130101) B63B 59/08 (20130101) Hydraulic Engineering E02B 17/0034 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20230092749 — HIGH THROUGHPUT SNAPSHOT SPECTRAL ENCODING DEVICE FOR FLUORESCENCE SPECTRAL MICROSCOPY
| US 20230092749 | Cutrale et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | University of Southern California (Los Angeles, California) |
| INVENTOR(S) | Francesco Cutrale (Los Angeles, California); Pu Wang (Los Angeles, California); Scott E. Fraser (Los Angeles, California) |
| ABSTRACT | Systems and methods are provided for multi-spectral or hyper-spectral fluorescence imaging. In one example, a spectral encoding device may be positioned in a detection light path between a detection objective and an imaging sensor of a microscope. In one example, the spectral encoding device includes a first dichroic mirror having a sine transmittance profile and a second dichroic mirror having a cosine transmittance profile. In addition to collecting transmitted light, reflected light from each dichroic mirror is collected and used for total intensity normalization and image analysis. |
| FILED | Friday, March 12, 2021 |
| APPL NO | 17/911006 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 21/6458 (20130101) Original (OR) Class G01N 2021/6417 (20130101) G01N 2021/6439 (20130101) G01N 2201/0636 (20130101) Optical Elements, Systems, or Apparatus G02B 21/16 (20130101) G02B 21/365 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230092795 | Angelini et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas Ettor Angelini (Gainesville, Florida); Brent S. Sumerlin (Gainesville, Florida); Christopher S. O'Bryan (Gainesville, Florida); Georg Scheutz (Gainesville, Florida) |
| ABSTRACT | Described herein are compositions, methods, kits, and systems relating to smooth, spherical microgels which can be charge-neutral. The microgels can be made using an emulsification process. In certain aspects, charge-neutral microgels as described herein are suitable for 3D cell culture, use in perfusion bioreactors, and/or 3D printing of cells for 3D cell culture. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/802686 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 70/00 (20141201) Apparatus for Enzymology or Microbiology; C12M 25/18 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0062 (20130101) Original (OR) Class C12N 2533/30 (20130101) C12N 2537/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230092901 | Mondry et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jack Mondry (Edina, Minnesota); Shane Farritor (Lincoln, Nebraska); Eric Markvicka (Brush, Colorado); Thomas Frederick (Lincoln, Nebraska); Joe Bartels (Pittsburgh, Pennsylvania) |
| ABSTRACT | Disclosed herein are various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices. Also disclosed are various medical devices for in vivo medical procedures. Included herein, for example, is a surgical robotic device having an elongate device body, a right robotic arm coupled to a right shoulder assembly, and a left robotic arm coupled to a left shoulder assembly. |
| FILED | Monday, November 28, 2022 |
| APPL NO | 18/058904 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/00234 (20130101) A61B 34/20 (20160201) A61B 34/30 (20160201) Original (OR) Class A61B 90/361 (20160201) A61B 2017/2906 (20130101) Manipulators; Chambers Provided With Manipulation Devices B25J 9/0084 (20130101) B25J 9/0087 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230093224 | Galloway |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin Galloway (Annapolis, Maryland) |
| ABSTRACT | This disclosure, and the exemplary embodiments provided herein, include a system and method for encoding information in a relatively dense and time-varying manner. In exemplary embodiments, a reflector or retroreflector is wrapped around a rotating member, such as a cylinder, (also referred to as “Rotational LIDAR Barcodes”), which encodes relatively longer data messages, as compared to a static barcode, which can be detected by a LIDAR system and decoded from every direction, i.e. bearings angles of 0-360 degrees, even when partially obstructed. |
| FILED | Wednesday, September 21, 2022 |
| APPL NO | 17/950065 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/006 (20130101) Original (OR) Class G01S 17/74 (20130101) G01S 17/931 (20200101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 7/1413 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230093228 | Schwede et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Spark Thermionics, Inc. (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jared William Schwede (Berkeley, California); Lucas Heinrich Hess (Berkeley, California) |
| ABSTRACT | A thermionic energy converter, preferably including an anode and a cathode. An anode of a thermionic energy converter, preferably including an n-type semiconductor, one or more supplemental layers, and an electrical contact. A method for work function reduction and/or thermionic energy conversion, preferably including inputting thermal energy to a thermionic energy converter, illuminating an anode of the thermionic energy converter, thereby preferably reducing a work function of the anode, and extracting electrical power from the system. |
| FILED | Wednesday, November 23, 2022 |
| APPL NO | 17/993195 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 45/00 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 35/14 (20130101) H01L 35/18 (20130101) H01L 35/22 (20130101) H01L 35/30 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230093246 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Nien-Hwa Linda WANG (West Lafayette, Indiana); David HARVEY (West Lafayette, Indiana); Yi DING (West Lafayette, Indiana); Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nien-Hwa Linda Wang (West Lafayette, Indiana); David Harvey (West Lafayette, Indiana); Yi Ding (West Lafayette, Indiana) |
| ABSTRACT | A method of recovering substantially rare earth elements (REEs) from magnets, including first dissolving a magnet to yield a solution containing Nd, Pr, and Dy, and then equilibrating a first column with Cu2+ solution to yield a first equilibrated column, introducing the solution to the first equilibrated column, and introducing a ligand solution to the first equilibrated column to establish three bands of different liquid compositions in the column, wherein the three bands comprise a Dy/Nd mixed band, a first pure Nd band, and a Nd/Pr mixed band. Next, sending the Dy/Nd mixed band to a second column containing a Cu2+ solution and introducing a ligand solution to the second column to establish a pure Dy band and a second pure Nd band in the second column, and sending the Nd/Pr mixed band to a third column containing a Cu2+ solution and introducing a ligand solution to the third column to establish a third pure Nd band and a pure Pr band in the third column. Finally, eluting the respective pure Nd bands to recover Nd, eluting the pure Dy band to recover Dy, and eluting the pure Pr band to recover Pr. |
| FILED | Thursday, January 28, 2021 |
| APPL NO | 17/797826 |
| CURRENT CPC | Separation B01D 15/203 (20130101) B01D 15/1878 (20130101) B01D 15/3828 (20130101) Production and Refining of Metals; Pretreatment of Raw Materials C22B 3/42 (20130101) C22B 3/065 (20130101) C22B 59/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230093340 | Kvryan |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Armen Kvryan (Glendale, California) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Armen Kvryan (Glendale, California) |
| ABSTRACT | Provided is a protective mask that includes one or more layers of an air-permeable aerogel. The aerogel can be nonmetallic, metallic, metallic oxide, semi-conductive, or any combination thereof. The protective mask can include a nonmetallic interior layer and a metallic or metallic oxide exterior layer surrounding the nonmetallic interior layer. Alternatively, the facemask can include a semi-conductive layer, a power source, and a customizable switch. The pore size of the aerogel can be selected from a size ranging from <1 to 100 nanometers based on intended use. One or more layers can be incorporated into a facemask or respirator filter to protect a user from nanometric airborne particles, harmful chemicals used in industry, and the like. The filter is reusable and the pore size can be customized to deny entry to almost any size of particulate that is desired. |
| FILED | Tuesday, September 20, 2022 |
| APPL NO | 17/948494 |
| CURRENT CPC | Devices, Apparatus or Methods for Life-saving A62B 23/025 (20130101) Original (OR) Class Separation B01D 39/1676 (20130101) B01D 39/2051 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230093578 | Ruskuc et al. |
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| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrei Ruskuc (Pasadena, California); Joonhee Choi (Pasadena, California); Chun-Ju Wu (Pasadena, California); Andrei Faraon (La Canada Flintridge, California) |
| ABSTRACT | A system for coupling a qubit to a register, wherein the system controls application of a protocol comprising a sequence of pulses synchronized with an RF field, the protocol further comprising a timing, a phase, and a duration of each of the pulses comprising a single qubit gate, a period and amplitude of the RF field, and a number of repeats of the sequence, so that application of the protocol controls a coherent spin exchange interaction between a register and a qubit having a zero magnetic dipole moment. The qubit comprises a first spin state and a second spin state both of which have a zero magnetic dipole moment; the register comprises multiple register spins having an energy level structure; and the register spins are indistinguishable so as to be configurable in basis states including a superposition state used for storing the quantum state of the qubit. |
| FILED | Tuesday, August 30, 2022 |
| APPL NO | 17/899291 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/20 (20220101) G06N 10/40 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20230085758 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Brigham Young University (BYU) (Provo, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Guimin Chen (Provo, Utah); Larry Howell (Orem, Utah); Spencer Magleby (Provo, Utah) |
| ABSTRACT | A lamina emergent torsional (LET) joint that includes an integrated membrane to reduce, or eliminate, certain unwanted motions and/or displacements associated with the operation of the LET joint is disclosed. The membrane-integrated LET joint (i.e., M-LET) can be used as a hinge for a lamina emergent mechanism and/or as a surrogate fold for an origami application to ensure accurate and repeatable transitions from a planar (i.e., lamina) state to a non-planar (i.e., lamina-emergent) state, and vice versa. |
| FILED | Thursday, November 17, 2022 |
| APPL NO | 18/056522 |
| CURRENT CPC | Springs; Shock-absorbers; Means for Damping Vibration F16F 1/027 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230085867 | Rakin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents of behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adnan Siraj Rakin (Tempe, Arizona); Deliang Fan (Tempe, Arizona); Sai Kiran Cherupally (Tempe, Arizona); Jae-sun Seo (Tempe, Arizona) |
| ABSTRACT | Method, systems, and devices, disclosed herein can leverage noise and aggressive quantization of in-memory computing (IMC) to provide robust deep neural network (DNN) hardware against adversarial input and weight attacks. IMC substantially improves the energy efficiency of DNN hardware by activating many rows together and performing analog computing. The noisy analog IMC induces some amount of accuracy drop in hardware acceleration, which is generally considered as a negative effect. However, this disclosure demonstrates that such hardware intrinsic noise can, on the contrary, play a positive role in enhancing adversarial robustness. To achieve this, a new DNN training scheme is proposed that integrates measured IMC hardware noise and aggressive partial sum quantization at the IMC crossbar. It is shown that this effectively improves the robustness of IMC DNN hardware against both adversarial input and weight attacks. |
| FILED | Tuesday, September 13, 2022 |
| APPL NO | 17/931682 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/64 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/063 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230086022 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Liping Wang (Chandler, Arizona); Linshuang Long (Hefei, China PRC); Sydney Taylor (Charlestown, Rhode Island) |
| ASSIGNEE(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| INVENTOR(S) | Liping Wang (Chandler, Arizona); Linshuang Long (Hefei, China PRC); Sydney Taylor (Charlestown, Rhode Island) |
| ABSTRACT | A layered thermochromic device for enhanced infrared emission, and method for creating the same is disclosed. The method includes deposing a spacer layer of HfO2 upon a metallic layer, spin coating the spacer layer with photoresist, exposing the photoresist with a photomask, creating a plurality of holes in the photoresist, and deposing vanadium on the photoresist and the plurality of holes, filling the holes and forming vanadium microdisks on the spacer layer. The method also includes removing the photoresist and the vanadium deposed on the photoresist, and forming a thermochromic layer having VO2 coupled to the spacer layer through direct oxidation of the deposed vanadium microdisks by heating the device in a furnace under a nitrogen/oxygen flow. The device includes a metallic layer, a spacer layer coupled to the metallic layer, and a thermochromic layer deposed on the spacer layer opposite the metallic layer. |
| FILED | Thursday, June 02, 2022 |
| APPL NO | 17/831160 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 5/208 (20130101) Original (OR) Class Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/0005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230086188 | Dzuricky et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Dzuricky (Durham, North Carolina); Ashutosh Chilkoti (Durham, North Carolina) |
| ABSTRACT | Described herein are peptide biopolymers that exhibit controlled phase separation based on their amino acid sequence, aromatic:aliphatic ratio, hydrophobicity, temperature, molecular weight, and concentration. |
| FILED | Wednesday, March 03, 2021 |
| APPL NO | 17/908427 |
| CURRENT CPC | Peptides C07K 14/435 (20130101) Original (OR) Class C07K 2319/35 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230086246 | Kartalov et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Emil P. Kartalov (Pasadena, California); Aditya Rajagopal (Orange, California); Axel Scherer (Pasadena, California) |
| ABSTRACT | This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte. |
| FILED | Wednesday, August 10, 2022 |
| APPL NO | 17/885037 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) C12Q 1/6825 (20130101) Original (OR) Class C12Q 1/6851 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6486 (20130101) Electric Digital Data Processing G06F 17/10 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) G16B 25/00 (20190201) G16B 25/20 (20190201) G16B 40/10 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230086446 | dos Santos Fajardo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ana dos Santos Fajardo (Marinha Grande, Portugal); Sergio Garcia-Segura (Tempe, Arizona); Gabriel Cerron Calle (Tempe, Arizona); Carlos M. Sanchez (Paris, France) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ana dos Santos Fajardo (Marinha Grande, Portugal); Sergio Garcia-Segura (Tempe, Arizona); Gabriel Cerron Calle (Tempe, Arizona); Carlos M. Sanchez (Paris, France) |
| ABSTRACT | A nanocomposite electrode includes a porous copper substrate and platinum nanoparticles electrolytically deposited on the porous copper substrate. Making a nanocomposite electrode includes contacting a porous copper substrate with a solution including platinum, and electrodepositing the platinum on the porous copper substrate. |
| FILED | Friday, September 16, 2022 |
| APPL NO | 17/946185 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/38 (20130101) Original (OR) Class H01M 4/045 (20130101) H01M 4/0404 (20130101) H01M 4/661 (20130101) H01M 4/745 (20130101) H01M 2004/021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230086952 | Green et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Matthew Green (Phoenix, Arizona); Yi Yang (Mesa, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Green (Phoenix, Arizona); Yi Yang (Mesa, Arizona) |
| ABSTRACT | A zwitterionic polysulfone formed from an allyl-containing monomer, a phenol-containing monomer, and an aryl-halide-containing monomer. The zwitterionic polysulfone may be incorporated into a desalination membrane. |
| FILED | Friday, November 11, 2022 |
| APPL NO | 17/985288 |
| CURRENT CPC | Separation B01D 71/68 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/44 (20130101) C02F 2103/08 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 75/23 (20130101) Original (OR) Class Compositions of Macromolecular Compounds C08L 81/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230087043 | Mancebo |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ricardo Mancebo (Fremont, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ricardo Mancebo (Fremont, California) |
| ABSTRACT | The invention relates to the amplification of specific target nucleic acids. The invention provides methods, reagents, and kits for carrying out such amplification via the autoligation chain reaction (ACR). |
| FILED | Monday, May 02, 2022 |
| APPL NO | 17/734226 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6853 (20130101) Original (OR) Class C12Q 1/6862 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230087420 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MIAMI (Miami, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shanghao Li (Miami, Florida); Roger M. Leblanc (Key Biscayne, Florida); Isaac Skromne (Pinecrest, Florida); Zhili Peng (Miami, Florida) |
| ABSTRACT | The disclosure provides a method of forming carbon dots, including admixing carbon powder with sulfuric acid and nitric acid and heating the carbon powder mixture to reflux to oxidize the carbon powder. The method further includes isolating and purifying the carbon dots. The disclosure further provides applications of the carbon dots for diagnostic analysis (such as bone analysis), fibrillation inhibition, and drug delivery. |
| FILED | Tuesday, November 22, 2022 |
| APPL NO | 17/992783 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/5123 (20130101) A61K 47/06 (20130101) A61K 49/0065 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/15 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230087700 | Hersam et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark C. Hersam (Wilmette, Illinois); Woo Jin Hyun (Evanston, Illinois) |
| ABSTRACT | One aspect of this invention relates to hexagonal boron nitride (hBN) ionogel inks using exfoliated hBN nanoplatelets as the solid matrix. The hBN nanoplatelets are produced from bulk hBN powders by liquid-phase exfoliation, allowing printable hBN ionogel inks to be formulated following the addition of an imidazolium ionic liquid and ethyl lactate. The resulting inks are reliably printed with variable patterns and controllable thicknesses by aerosol jet printing, resulting in hBN ionogels that possess high room-temperature ionic conductivities and storage moduli of >3 mS cm-1 and >1 MPa, respectively. By integrating the hBN ionogel with printed semiconductors and electrical contacts, fully-printed thin-film transistors with operating voltages below 1 V are demonstrated on polyimide films. These devices exhibit desirable electrical performance and robust mechanical tolerance against repeated bending cycles, thus confirming the suitability of hBN ionogels for printed and flexible electronics. |
| FILED | Thursday, January 28, 2021 |
| APPL NO | 17/798618 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/033 (20130101) C09D 11/52 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230087931 | Ng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); THE UNIVERSITY OF SOUTHERN MISSISSIPPI (Hattiesburg, Mississippi) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tse Nga Ng (San Diego, California); Lulu Yao (San Diego, California); Jason Azoulay (Hattiesburg, Mississippi) |
| ABSTRACT | Embodiments of the presently disclosed technology provide a synergistic combination of a conjugated open-shell donor-acceptor polymer with a carbon-based compound (e.g., reduced graphene oxide) to produce a composite electrode material which demonstrates state-of-the-art capacitance and potential window, with excellent kinetics and cycle life. The conjugated open-shell donor-acceptor polymer may comprise a plurality of alternating electron-rich monomers (i.e., donors) and electron-deficient monomers (i.e., acceptors) bonded together via a conjugated backbone. The conjugated backbone may comprise a connection of n-orbitals of the plurality of monomers in alternating single and double bonds that facilitates unpaired electron delocalization—thereby stabilizing charge for the polymer. The carbon-based compound of the composite electrode material may provide porous, conductive scaffolds for the composite electrode material, resulting in electrodes scalable to microns-thick films with fast kinetics. |
| FILED | Tuesday, June 14, 2022 |
| APPL NO | 17/840124 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 61/126 (20130101) Original (OR) Class C08G 2261/44 (20130101) C08G 2261/124 (20130101) C08G 2261/514 (20130101) C08G 2261/3223 (20130101) C08G 2261/3246 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/042 (20170501) C08K 2201/001 (20130101) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/32 (20130101) H01G 11/48 (20130101) H01G 11/86 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230088558 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Boston College (Chestnut Hill, Massachusetts) |
| ASSIGNEE(S) | The Trustees of Boston College (Chestnut Hill, Massachusetts) |
| INVENTOR(S) | Dunwei Wang (Newton, Massachusetts); Haochuan Zhang (Brighton, Massachusetts); Jingru Luo (San Jose, California) |
| ABSTRACT | The present invention provides a method of making fire-resistant battery cells comprising nonflammable electrolytes, and use thereof. |
| FILED | Friday, September 16, 2022 |
| APPL NO | 17/932807 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/134 (20130101) H01M 4/136 (20130101) H01M 10/44 (20130101) H01M 10/058 (20130101) H01M 10/0525 (20130101) H01M 50/143 (20210101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230088979 | Neogi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Reg. of the Univ. of CO, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sanghamitra Neogi (Boulder, Colorado); Artem Konstantinovich Pimachev (Boulder, Colorado) |
| ABSTRACT | A method for determining electronic band structure includes partitioning, based on a location of each of a plurality of atoms forming a crystalline structure, a volume of the crystalline structure to obtain Voronoi tessellations. The method also includes constructing, based on the Voronoi tessellations, a plurality of crystal graphs and deriving, based on the plurality of crystal graphs, one or more local structural features of the crystalline structure. The method also includes feeding, into a trained machine-learning model, the one or more local structural features, one or more global structural features of the crystalline structure, and one or more species-based features of the crystalline structure. The trained machine-learning model, in response to said feeding, returns a plurality of energy values that sample a Brillouin zone of the crystalline structure. |
| FILED | Thursday, September 08, 2022 |
| APPL NO | 17/930619 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/2648 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230089076 | TURNER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (Blacksburg, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sam Richard TURNER (Blacksburg, Virginia); Richard David GANDOUR (Blacksburg, Virginia); Chanelle J. BROWN (Blacksburg, Virginia); Anna STEELE (Blacksburg, Virginia); John B. MATSON (Blacksburg, Virginia) |
| ABSTRACT | In one aspect, the disclosure relates to the production of alternating polymers of maleic anhydride or an N-substituted maleimide with a stilbene. |
| FILED | Monday, September 19, 2022 |
| APPL NO | 17/947803 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 2/08 (20130101) C08F 222/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230089278 | Kishore Kumar, Ph.d et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Deepan Kishore Kumar, Ph.d (Pasadena, California); Nai-Chang Yeh (Pasadena, California) |
| ABSTRACT | Described are devices, such as light emitters, lasers, and switches, and methods, such as methods of generating photoluminescence and methods of fabricating electronic devices. Example devices and methods described include those comprising or employing optically active graphene, such as in the form of one or more layers of quasi-1D graphene nanomaterials or graphene nanostripes including one or more topological defects. Optically active graphene can emit photoluminescence upon exposure to photoexcitation and can also generate laser emission, optionally as a frequency comb. The optically active graphene can be patterned onto substrates according to the disclosed methods of fabricating electronic devices and is optionally useful for generating optical switches. |
| FILED | Thursday, September 22, 2022 |
| APPL NO | 17/950421 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 15/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/19 (20170801) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/65 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230089348 | Seok et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mingoo Seok (Tenafly, New Jersey); Zhewei Jiang (Oakland Gardens, New York); Jae-sun Seo (Tempe, Arizona); Shihui Yin (Mesa, Arizona) |
| ABSTRACT | In some embodiments, an in-memory-computing SRAM macro based on capacitive-coupling computing (C3) (which is referred to herein as “C3SRAM”) is provided. In some embodiments, a C3SRAM macro can support array-level fully parallel computation, multi-bit outputs, and configurable multi-bit inputs. The macro can include circuits embedded in bitcells and peripherals to perform hardware acceleration for neural networks with binarized weights and activations in some embodiments. In some embodiments, the macro utilizes analog-mixed-signal capacitive-coupling computing to evaluate the main computations of binary neural networks, binary-multiply-and-accumulate operations. Without needing to access the stored weights by individual row, the macro can assert all of its rows simultaneously and form an analog voltage at the read bitline node through capacitive voltage division, in some embodiments. With one analog-to-digital converter (ADC) per column, the macro cab realize fully parallel vector-matrix multiplication in a single cycle in accordance with some embodiments. |
| FILED | Tuesday, May 31, 2022 |
| APPL NO | 17/828964 |
| CURRENT CPC | Electric Digital Data Processing G06F 7/501 (20130101) G06F 7/5443 (20130101) Static Stores G11C 7/1036 (20130101) Original (OR) Class G11C 7/1051 (20130101) G11C 7/1078 (20130101) G11C 15/04 (20130101) G11C 15/043 (20130101) G11C 16/3404 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230089481 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Huan Liu (Tempe, Arizona); Kaize Ding (Tempe, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on Behalf of Arizona State University (Tempe, Arizona) |
| INVENTOR(S) | Huan Liu (Tempe, Arizona); Kaize Ding (Tempe, Arizona) |
| ABSTRACT | Various embodiments for few-shot network anomaly detection via cross-network meta-learning are disclosed herein. An anomaly detection system incorporating a new family of graph neural networks—Graph Deviation Networks (GDN) can leverage a small number of labeled anomalies for enforcing statistically significant deviations between abnormal and normal nodes on a network. Further, the GDN is equipped with a new cross-network meta-learning algorithm (Meta-GDN) to realize few-shot network anomaly detection by transferring meta-knowledge from multiple auxiliary networks. Extensive evaluations demonstrate the efficacy of the anomaly detection system and the Meta-GDN on few-shot or even one-shot network anomaly detection. |
| FILED | Friday, August 12, 2022 |
| APPL NO | 17/819446 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6256 (20130101) Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230089497 | ZHANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qi ZHANG (Tempe, Arizona); Xiao WANG (Chandler, Arizona); Alexander GREEN (Chestnut Hill, Massachusetts); Duo MA (Tempe, Arizona); Fuqing WU (Tempe, Arizona); Kylie STANDAGE-BEIER (Phoenix, Arizona); Xingwen CHEN (Tempe, Arizona) |
| ABSTRACT | The present invention provides a new class of RNA modules, referred to as degradation tuning RNAs (dtRNAs), which form stabilizing secondary structures. Also provided are methods of using dtRNAs to modulate the stability of RNAs. DNA constructs including a promoter that is operably connected to a sequence encoding the dtRNA are also provided. |
| FILED | Wednesday, March 03, 2021 |
| APPL NO | 17/909345 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/67 (20130101) Original (OR) Class C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230089653 | Ozias-Akins et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (Athens, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peggy Ozias-Akins (Tifton, Georgia); Joann A. Conner (Tifton, Georgia) |
| ABSTRACT | Methods and compositions disclosed herein relate to genes involved in plant production and methods of using the same. |
| FILED | Tuesday, July 12, 2022 |
| APPL NO | 17/812022 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8287 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230089692 | Pyun et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dong-Chul Pyun (Tucson, Arizona); Yueyan Zhang (Tucson, Arizona) |
| ABSTRACT | An iterative approach to dynamic covalent polymerizations of elemental sulfur with functional comonomers to prepare sulfur prepolymers that can further react with other conventional, commercially available comonomers to prepare a wider class of functional sulfur polymers. This iterative method improves handling, miscibility and solubility of the elemental sulfur, and further enables tuning of the sulfur polymer composition. The sulfur polymers may be a thermoplastic or a thermoset for use in elastomers, resins, lubricants, coatings, antioxidants, cathode materials for electrochemical cells, and polymeric articles such as polymeric films and free-standing substrates. |
| FILED | Monday, October 31, 2022 |
| APPL NO | 18/051342 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 41/12 (20130101) A01N 59/02 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/795 (20130101) Non-metallic Elements; Compounds Thereof; C01B 3/042 (20130101) C01B 17/96 (20130101) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/64 (20130101) C04B 35/6303 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 75/16 (20130101) Original (OR) Class Compositions of Macromolecular Compounds C08L 81/04 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/0404 (20130101) H01M 4/606 (20130101) H01M 4/608 (20130101) H01M 4/664 (20130101) H01M 4/5815 (20130101) H01M 10/052 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230090146 | GOUAL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WYOMING (Laramie, Wyoming) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lamia GOUAL (Laramie, Wyoming); Tianzhu QIN (Laramie, Wyoming); Gina JAVANBAKHT (Laramie, Wyoming); Mohammad PIRI (Laramie, Wyoming) |
| ABSTRACT | Novel microemulsion formulations comprising a surfactant or combination of surfactants are disclosed for improved crude oil cleanup or recovery from subsurface geological formations, especially those containing carbonate cements. |
| FILED | Tuesday, October 18, 2022 |
| APPL NO | 17/968700 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 8/524 (20130101) C09K 8/584 (20130101) Original (OR) Class Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 43/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230092812 | Goldfarb et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Goldfarb (Nashville, Tennessee); Steven C. Culver (Nashville, Tennessee) |
| ABSTRACT | A knee prosthesis or orthosis includes at least one moveable joint and a torque modulating unit. The torque modulating unit is configured to impose a controllable torque on the at least one moveable joint. The torque modulating unit includes at least one of a motor or brake. The at least one of the motor or brake is coupled to the at least one moveable joint via an electronically-controlled transmission. The electronically-controlled transmission is a two-speed transmission. |
| FILED | Monday, February 22, 2021 |
| APPL NO | 17/798627 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/64 (20130101) Original (OR) Class A61F 2/70 (20130101) A61F 2002/503 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230092901 | Mondry et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jack Mondry (Edina, Minnesota); Shane Farritor (Lincoln, Nebraska); Eric Markvicka (Brush, Colorado); Thomas Frederick (Lincoln, Nebraska); Joe Bartels (Pittsburgh, Pennsylvania) |
| ABSTRACT | Disclosed herein are various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices. Also disclosed are various medical devices for in vivo medical procedures. Included herein, for example, is a surgical robotic device having an elongate device body, a right robotic arm coupled to a right shoulder assembly, and a left robotic arm coupled to a left shoulder assembly. |
| FILED | Monday, November 28, 2022 |
| APPL NO | 18/058904 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/00234 (20130101) A61B 34/20 (20160201) A61B 34/30 (20160201) Original (OR) Class A61B 90/361 (20160201) A61B 2017/2906 (20130101) Manipulators; Chambers Provided With Manipulation Devices B25J 9/0084 (20130101) B25J 9/0087 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230093007 | GIBBONS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PRAIRIE AQUATECH LLC (Brookings, South Dakota) |
| ASSIGNEE(S) | PRAIRIE AQUATECH LLC (Brookings, South Dakota) |
| INVENTOR(S) | WILLIAM GIBBONS (BROOKINGS, South Dakota); Michael L. Brown (Volga, South Dakota) |
| ABSTRACT | The present invention describes a bio-based process to produce high quality protein concentrate (HQPC) by converting plant derived celluloses into bioavailable protein via aerobic incubation, including the use of such HQPC so produced as a nutrient, including use as a fish meal replacement in aquaculture diets. |
| FILED | Monday, September 12, 2022 |
| APPL NO | 17/942759 |
| CURRENT CPC | Protein Compositions for Foodstuffs; Working-up Proteins for Foodstuffs; Phosphatide Compositions for Foodstuffs A23J 1/14 (20130101) A23J 1/125 (20130101) Original (OR) Class A23J 1/148 (20130101) Fodder A23K 10/14 (20160501) A23K 10/38 (20160501) A23K 20/147 (20160501) A23K 40/20 (20160501) A23K 40/25 (20160501) A23K 50/80 (20160501) Technologies for Adaptation to Climate Change Y02A 40/818 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20230093063 — DEVICES INCLUDING FERROELECTRIC NEMATIC MATERIAL AND METHODS OF FORMING AND USING SAME
| US 20230093063 | Clark et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado); University of Utah Research Foundation (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Noel A. Clark (Boulder, Colorado); Xi Chen (Boulder, Colorado); Matthew A. Glaser (Boulder, Colorado); Joseph E. Maclennan (Boulder, Colorado); Dengpan Dong (Salt Lake City, Utah); Dimitry Bedrov (Sandy, Utah) |
| ABSTRACT | Devices including nematic liquid crystal-forming molecules are disclosed. The molecules include one or more dipoles and exist in a ferroelectric nematic state. Exemplary devices can further include an electrode for applying an electric field in, for example, and in-plane direction. |
| FILED | Wednesday, March 03, 2021 |
| APPL NO | 17/909276 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/0045 (20130101) G02F 1/0136 (20130101) G02F 1/141 (20130101) Original (OR) Class G02F 1/1358 (20130101) G02F 2202/01 (20130101) Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 10/00 (20190201) G16C 20/20 (20190201) Techniques for Handling Particles or Ionising Radiation Not Otherwise Provided For; Irradiation Devices; Gamma Ray or X-ray Microscopes G21K 1/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230093578 | Ruskuc et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrei Ruskuc (Pasadena, California); Joonhee Choi (Pasadena, California); Chun-Ju Wu (Pasadena, California); Andrei Faraon (La Canada Flintridge, California) |
| ABSTRACT | A system for coupling a qubit to a register, wherein the system controls application of a protocol comprising a sequence of pulses synchronized with an RF field, the protocol further comprising a timing, a phase, and a duration of each of the pulses comprising a single qubit gate, a period and amplitude of the RF field, and a number of repeats of the sequence, so that application of the protocol controls a coherent spin exchange interaction between a register and a qubit having a zero magnetic dipole moment. The qubit comprises a first spin state and a second spin state both of which have a zero magnetic dipole moment; the register comprises multiple register spins having an energy level structure; and the register spins are indistinguishable so as to be configurable in basis states including a superposition state used for storing the quantum state of the qubit. |
| FILED | Tuesday, August 30, 2022 |
| APPL NO | 17/899291 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/20 (20220101) G06N 10/40 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230093708 | Dzuricky et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Dzuricky (Durham, North Carolina); Ashutosh Chilkoti (Durham, North Carolina) |
| ABSTRACT | Described herein are protein nanoparticles comprising a fusion protein comprising at least one binding polypeptide and at least one unstructured polypeptide, in one aspect, the nanoparticles comprise a di-block of repeats of a core polypeptide, repeats of a corona polypeptide, and one or more binding proteins. The nanoparticles can be used as therapeutic agents, targeted-delivery agents, separation agents, or purification agents. |
| FILED | Wednesday, March 03, 2021 |
| APPL NO | 17/908415 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Peptides C07K 14/005 (20130101) C07K 14/31 (20130101) C07K 14/78 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230093754 | GIBBONS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PRAIRIE AQUATECH LLC (Brookings, South Dakota) |
| ASSIGNEE(S) | PRAIRIE AQUATECH LLC (Brookings, South Dakota) |
| INVENTOR(S) | WILLIAM GIBBONS (BROOKINGS, South Dakota); Michael L. Brown (Volga, South Dakota) |
| ABSTRACT | The present invention describes a bio-based process to produce high quality protein concentrate (HQPC) by converting plant derived celluloses into bioavailable protein via aerobic incubation, including the use of such HQPC so produced as a nutrient, including use as a fish meal replacement in aquaculture diets. |
| FILED | Tuesday, September 27, 2022 |
| APPL NO | 17/953640 |
| CURRENT CPC | Protein Compositions for Foodstuffs; Working-up Proteins for Foodstuffs; Phosphatide Compositions for Foodstuffs A23J 1/14 (20130101) A23J 1/125 (20130101) Original (OR) Class A23J 1/148 (20130101) Fodder A23K 10/14 (20160501) A23K 10/38 (20160501) A23K 20/147 (20160501) A23K 40/20 (20160501) A23K 40/25 (20160501) A23K 50/80 (20160501) Technologies for Adaptation to Climate Change Y02A 40/818 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20230086059 | Gailus |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Nanocomp Technologies, Inc. (The Woodlands, Texas) |
| ASSIGNEE(S) | Nanocomp Technologies, Inc. (The Woodlands, Texas) |
| INVENTOR(S) | David Gailus (Merrick, New Hampshire) |
| ABSTRACT | The present disclosure provides a filter for removing contaminants from a liquid or gaseous medium including a woven or nonwoven sheet of entangled carbon nanotubes. The present disclosure also provides a method for reducing the concentration of contaminants in a liquid or gaseous medium by contacting the liquid or gaseous medium with the filter. |
| FILED | Monday, March 01, 2021 |
| APPL NO | 17/801305 |
| CURRENT CPC | Separation B01D 46/0036 (20130101) B01D 53/0438 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/205 (20130101) Original (OR) Class B01J 20/28007 (20130101) B01J 20/28011 (20130101) B01J 20/28038 (20130101) B01J 20/28061 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/158 (20170801) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/283 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230086140 | Thompson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jesse G. Thompson (Lexington, Kentucky); Kunlei Liu (Lexington, Kentucky); Leland Widger (St. Clair, Michigan); Daniel Moreno (Hauppauge, New York); Ayokunle Omosebi (Lexington, Kentucky); James Landon (Lexington, Kentucky) |
| ABSTRACT | An electrochemical reactor system adapted for producing a chemical product from a reactant includes (a) separate electrochemical and production cells and (b) a charge carrier compound in a catholyte adapted to effectively decouple the charging of the charge carrier compound in the electrochemical cell with the electrochemical conversion of a reactant to a desired chemical product in the production cell. |
| FILED | Friday, September 23, 2022 |
| APPL NO | 17/951895 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 9/15 (20210101) C25B 9/19 (20210101) Original (OR) Class C25B 11/043 (20210101) C25B 11/046 (20210101) C25B 13/04 (20130101) C25B 15/031 (20210101) C25B 15/087 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230086985 | Lindsey et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan S. Lindsey (Raleigh, North Carolina); Masahiko Taniguchi (Raleigh, North Carolina) |
| ABSTRACT | Described herein are polymeric compounds including an acceptor dye and donor luminophore, a polymer, and optionally a bioconjugate group. A polymeric compound of the present invention may have a structure represented by: A-B-C or C-A-B, wherein A is an acceptor dye; B is a polymer comprising one or more hydrophobic unit(s) and one or more hydrophilic unit(s); and optionally C, wherein C, when present, comprises a bioconjugate group, wherein one or more donor luminophore(s) are each separately attached to a portion of the polymer and/or to a portion of the acceptor dye. Also described herein are compositions comprising the polymeric compounds and methods of preparing and using the same. |
| FILED | Thursday, November 19, 2020 |
| APPL NO | 17/777762 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/0021 (20130101) A61K 49/0054 (20130101) Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 11/08 (20130101) C09B 69/108 (20130101) C09B 69/109 (20130101) Original (OR) Class Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) C09K 11/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230087130 | Palasyuk et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | lowa State University Research Foundation, Inc. (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andriy Palasyuk (Ames, Iowa); Tej Nath Lamichhane (Melrosse, Massachusetts); Olena Palesyuk (Ames, Iowa); Vladimir Antropov (Ames, Iowa); Paul C. Canfield (Ames, Iowa); Ralph W. McCallum (Sante Fe, New Mexico) |
| ABSTRACT | Provided are Ce/Co/Cu permanent magnet alloys containing certain refractory metals, such as Ta and/or Hf, and optionally Fe which represent economically more favorable alternative to Sm-based magnets with respect to both material and processing costs and which retain and/or improve magnetic characteristics useful for GAP MAGNET applications. |
| FILED | Monday, November 14, 2022 |
| APPL NO | 17/803760 |
| CURRENT CPC | Alloys C22C 19/07 (20130101) C22C 2202/02 (20130101) Changing the Physical Structure of Non-ferrous Metals and Non-ferrous Alloys C22F 1/10 (20130101) Original (OR) Class Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 29/52 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 1/047 (20130101) H01F 1/055 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230087465 | Ziehl et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of South Carolina (Columbia, South Carolina) |
| ASSIGNEE(S) | University of South Carolina (Columbia, South Carolina) |
| INVENTOR(S) | Paul Ziehl (Irmo, South Carolina); Vafa Soltangharaei (Columbia, South Carolina) |
| ABSTRACT | Described herein are systems and methods based on acoustic emission (AE) technology to monitor a concrete structure for a short interval and, based on signals acquired, estimate Alkali-silica reaction (ASR) progression status in the structure remotely and efficiently without halting any serviceability and operational activities of the structure, knowing the ASR progression status of the structure helps determine rehabilitation and future structural safety and serviceability of the structure. |
| FILED | Friday, July 08, 2022 |
| APPL NO | 17/860171 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/12 (20130101) G01N 29/14 (20130101) G01N 29/0654 (20130101) Original (OR) Class G01N 33/383 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230087700 | Hersam et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark C. Hersam (Wilmette, Illinois); Woo Jin Hyun (Evanston, Illinois) |
| ABSTRACT | One aspect of this invention relates to hexagonal boron nitride (hBN) ionogel inks using exfoliated hBN nanoplatelets as the solid matrix. The hBN nanoplatelets are produced from bulk hBN powders by liquid-phase exfoliation, allowing printable hBN ionogel inks to be formulated following the addition of an imidazolium ionic liquid and ethyl lactate. The resulting inks are reliably printed with variable patterns and controllable thicknesses by aerosol jet printing, resulting in hBN ionogels that possess high room-temperature ionic conductivities and storage moduli of >3 mS cm-1 and >1 MPa, respectively. By integrating the hBN ionogel with printed semiconductors and electrical contacts, fully-printed thin-film transistors with operating voltages below 1 V are demonstrated on polyimide films. These devices exhibit desirable electrical performance and robust mechanical tolerance against repeated bending cycles, thus confirming the suitability of hBN ionogels for printed and flexible electronics. |
| FILED | Thursday, January 28, 2021 |
| APPL NO | 17/798618 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/033 (20130101) C09D 11/52 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230087760 | ZHANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Lu ZHANG (Lisle, Illinois); Zhangxing SHI (Westmont, Illinois); Andrew JANSEN (Bolingbrook, Illinois); Stephen TRASK (Batavia, Illinois) |
| ABSTRACT | An silicon-containing electrode is formed by coating a silicon-containing slurry onto a conductive current collector. The slurry comprises a binder solution comprising a poly(carboxylic acid) binder dissolved in a mixed solvent system comprising an amide solvent of Formula I, as described herein, and a second solvent which can be water and/or an organic solvent. The binder preferably comprises poly(acrylic acid). The mixed solvent system comprises about 10 to about 99 vol % of the amide solvent of Formula I. The binder solution is utilized as a solvent for a slurry of silicon-containing particles for preparing the silicon-containing electrode. The slurries comprising the mixed solvent system have higher viscosity and are more stable than slurries containing the same concentrations of silicon particles, carbon particles, and binder in water as the sole solvent. |
| FILED | Tuesday, November 15, 2022 |
| APPL NO | 17/987605 |
| CURRENT CPC | Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/02 (20130101) C08K 3/04 (20130101) C08K 2003/023 (20130101) C08K 2201/005 (20130101) C08K 2201/011 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 1/00 (20130101) C09D 7/20 (20180101) C09D 7/67 (20180101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/22 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/134 (20130101) H01M 4/386 (20130101) H01M 4/0404 (20130101) H01M 4/0471 (20130101) H01M 4/622 (20130101) Original (OR) Class H01M 4/1395 (20130101) H01M 10/0525 (20130101) H01M 2004/027 (20130101) H01M 2220/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230088019 | HSU |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The George Washington University (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen HSU (Germantown, Maryland) |
| ABSTRACT | The present disclosure relates to microencapsulated friction modifiers additives used in lubricants or other solutions, to their preparation, and to the use thereof to improve fuel economy of the engines and machines by enhancing friction reduction and prolonging the friction reduction time period. |
| FILED | Friday, June 17, 2022 |
| APPL NO | 17/807584 |
| CURRENT CPC | Lubricating Compositions; Use of Chemical Substances Either Alone or as Lubricating Ingredients in a Lubricating Composition C10M 169/04 (20130101) C10M 177/00 (20130101) Original (OR) Class Indexing Scheme Associated With Subclass C10M Relating to Lubricating Compositions C10N 2020/019 (20200501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230088146 | Nord et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | FERMI RESEARCH ALLIANCE, LLC (Batavia, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian Dennis Nord (Geneva, Illinois); Benjamin McKinley Cohen (Rockville, Maryland) |
| ABSTRACT | A design optimization method and system comprises preparing a symbolic tree, updating node symbol parameters using a plurality of samples, sampling the plurality of samples with a method for solving, the multi-armed bandit problem, promoting each sample in the plurality of samples down a path of the symbolic tree, evaluating each path with a fitness function, and outputting a path of the symbolic tree. |
| FILED | Thursday, September 22, 2022 |
| APPL NO | 17/950594 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/20 (20200101) Original (OR) Class G06F 2111/06 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230088369 | Wachsman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | University of Maryland, College Park (College Park, Maryland) |
| INVENTOR(S) | Eric D. Wachsman (Fulton, Maryland); Adam Jolley (College Park, Maryland) |
| ABSTRACT | The present invention relates to rhomboidal phase bismuth oxide that maintains electric conductivity of at least about 1×10−2 S/cm at temperature of about 500° C. for at least about 100 hours. In particular, the bismuth oxides of the invention have stable conductivity at a temperature range from about 500° C. to about 550° C. |
| FILED | Saturday, November 19, 2022 |
| APPL NO | 17/990664 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/1266 (20130101) Original (OR) Class H01M 2008/1293 (20130101) H01M 2300/0074 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230088412 | Joshi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Vineet V. Joshi (Richland, Washington); Glenn J. Grant (Benton City, Washington); Curt A. Lavender (Richland, Washington); Scott A. Whalen (West Richland, Washington); Saumyadeep Jana (Kennewick, Washington); David Catalini (Hyattsville, Maryland); Jens T. Darsell (West Richland, Washington) |
| ABSTRACT | A shear assisted extrusion process for producing cladded materials wherein a cladding material and a material to be cladded are placed in sequence with the cladded material positioned to contact a rotating scroll face first and the material to be cladded second. The two materials are fed through a shear assisted extrusion device at a preselected feed rate and impacted by a rotating scroll face to generate a cladded extrusion product. This process allows for increased through wall strength and decreases the brittleness in formed structures as compared to the prior art. |
| FILED | Wednesday, November 09, 2022 |
| APPL NO | 17/984144 |
| CURRENT CPC | Manufacture of Metal Sheets, Wire, Rods, Tubes or Profiles, Otherwise Than by Rolling; Auxiliary Operations Used in Connection With Metal-working Without Essentially Removing Material B21C 23/002 (20130101) Original (OR) Class B21C 23/04 (20130101) B21C 23/22 (20130101) B21C 23/217 (20130101) B21C 23/218 (20130101) B21C 25/02 (20130101) B21C 27/02 (20130101) B21C 29/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230088835 | Mirkin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chad A. Mirkin (Wilmette, Illinois); Sasha B. Ebrahimi (DeKalb, Illinois); Devleena Samanta (Evanston, Illinois) |
| ABSTRACT | The present disclosure is directed to spherical nucleic acids (SNAs) comprising a nanoparticle core and an oligonucleotide, use of the SNAs to, e.g., detect target analytes, and methods of making the SNAs. In various embodiments, the target analyte is detected using the nanoparticle core, the oligonucleotide, or both. In some embodiments, the oligonucleotide comprises a detectable marker situated at an internal location within the oligonucleotide. In some aspects, the disclosure provides methods for detecting a target analyte comprising the step of contacting the target analyte with a spherical nucleic acid (SNA) and an agent, the SNA comprising a protein core and an oligonucleotide attached thereto, wherein the contacting of the protein core with the target analyte results in a change in the target analyte that is detectable by the agent, thereby detecting the target analyte. |
| FILED | Monday, July 20, 2020 |
| APPL NO | 17/908809 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/535 (20130101) G01N 33/5308 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230088880 | FORREST et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen R. FORREST (Ann Arbor, Michigan); Hafiz K.M. Sheriff, JR. (Ann Arbor, Michigan) |
| ABSTRACT | An organic photovoltaic device comprises a first electrode, at least one organic heterojunction layer positioned over the first electrode, a second electrode positioned over the organic heterojunction layer, and a thin film stack positioned over the second electrode, comprising a plurality of sublayers of a first dielectric material alternating with a plurality of sublayers of a second dielectric material, wherein at least one of the plurality of sublayers of the first dielectric material has a thickness that is different from another of the plurality of sublayers of the first dielectric material, wherein the organic photovoltaic device has a mean transmittance of between 10% and 100% for light between 420 nm and 670 nm, with a variance of ±10%, and wherein an index contrast between the sublayers in the thin film stack is at least 0.1. A method of fabricating an organic photovoltaic device is also disclosed. |
| FILED | Thursday, September 15, 2022 |
| APPL NO | 17/932577 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/392 (20200101) G06F 2111/06 (20200101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/442 (20130101) H01L 51/447 (20130101) Original (OR) Class H01L 51/4253 (20130101) H01L 2251/308 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230089190 | Chung et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Dow Global Technologies LLC (Midland, Michigan); EcoCatalytic Inc. (Woburn, Massachusetts) |
| ASSIGNEE(S) | Dow Global Technologies LLC (Midland, Michigan); EcoCatalytic Inc. (Woburn, Massachusetts) |
| INVENTOR(S) | Elena Y. Chung (Somerville, Massachusetts); John A. Sofranko (Woburn, Massachusetts); William K. Wang (Woburn, Massachusetts); Soumen Kundu (Pearland, Texas); Hangyao Wang (Freeport, Texas); Barry B. Fish (Freeport, Texas); Matthew T. Pretz (Freeport, Texas) |
| ABSTRACT | A process for oxidative dehydrogenation of a hydrocarbon to produce an olefin and water may include contacting, in a fluidized bed, the hydrocarbon with a particulate material, which may include at least one oxygen transfer agent (OTA) and at least one fluidization enhancing additive. During at least a portion of contacting the hydrocarbon with the particulate material, the fluidized bed may be at a temperature at or above a melting point of one or more materials of the oxygen transfer agent. Further, during at least a portion of contacting the hydrocarbon with the particulate material, a surface of at least a portion of the OTA may comprise a molten layer. The fluidization enhancing additive may not undergo reduction in the fluidized bed during contacting the hydrocarbon with the particulate material and may be present in an amount that maintains sufficient fluidization of the particulate material. |
| FILED | Friday, February 19, 2021 |
| APPL NO | 17/800756 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 5/48 (20130101) Original (OR) Class C07C 2521/02 (20130101) C07C 2523/08 (20130101) C07C 2523/14 (20130101) C07C 2523/34 (20130101) Cracking Hydrocarbon Oils; Production of Liquid Hydrocarbon Mixtures, e.g by Destructive Hydrogenation, Oligomerisation, Polymerisation; Recovery of Hydrocarbon Oils From Oil-shale, Oil-sand, or Gases; Refining Mixtures Mainly Consisting of Hydrocarbons; Reforming of Naphtha; Mineral Waxes C10G 27/04 (20130101) C10G 2400/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230089418 | Motkuri et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Radha K. Motkuri (Richland, Washington); Sayandev Chatterjee (Richland, Washington); Dushyant Barpaga (Richland, Washington); Bernard P. McGrail (Pasco, Washington) |
| ABSTRACT | Materials for binding per- and polyfluoroalkyl substances (PFAS) are disclosed. A fluidic device comprising the materials for detection and quantification of PFAS in a sample is disclosed. The fluidic device may be configured for multiplexed analyses. Also disclosed are methods for sorbing and remediating PFAS in a sample. The sample may be groundwater containing, or suspected of containing, one or more PFAS. |
| FILED | Wednesday, November 02, 2022 |
| APPL NO | 17/979454 |
| CURRENT CPC | Chemical Means for Extinguishing Fires or for Combating or Protecting Against Harmful Chemical Agents; Chemical Materials for Use in Breathing Apparatus A62D 3/38 (20130101) A62D 3/40 (20130101) A62D 3/115 (20130101) A62D 2101/22 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/226 (20130101) B01J 27/19 (20130101) B01J 27/188 (20130101) B01J 27/195 (20130101) B01J 27/198 (20130101) B01J 31/24 (20130101) B01J 35/004 (20130101) B01J 2231/005 (20130101) B01J 2531/74 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/30 (20130101) C02F 1/32 (20130101) C02F 1/283 (20130101) C02F 1/288 (20130101) Original (OR) Class C02F 1/583 (20130101) C02F 1/725 (20130101) C02F 2303/16 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/07 (20130101) G01N 27/48 (20130101) G01N 27/226 (20130101) G01N 33/1886 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230090559 | Alahyari et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Abbas A. Alahyari (Glastonbury, Connecticut); Kimberly Rae Saviers (Glastonbury, Connecticut); Jagadeesh Kumar Tangudu (South Windsor, Connecticut); Joseph Turney (Amston, Connecticut) |
| ABSTRACT | A stator and a motor including a stator. The stator includes a stator hub, a plurality of stator teeth extending from the stator hub that define a stator slot having a stator slot base, at least one winding disposed in the stator slot, and one or more oscillating heat pipes disposed at least partially in the at least one winding. The at least one winding is held apart from the stator slot base so that a cooling channel is defined between an inner winding portion of the at least one winding and a portion of the one or more oscillating heat pipes is disposed in the channel so cooling fluid can be passed between the stator slot base and the inner winding portion to cool the inner winding portion via at least operation of the one or more oscillating heat pipes. |
| FILED | Thursday, September 23, 2021 |
| APPL NO | 17/482737 |
| CURRENT CPC | Dynamo-electric Machines H02K 1/20 (20130101) H02K 3/12 (20130101) H02K 3/24 (20130101) H02K 3/34 (20130101) H02K 3/48 (20130101) H02K 9/20 (20130101) Original (OR) Class H02K 9/225 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230091038 | Kaplan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David L. Kaplan (Concord, Massachusetts); John Se Kit Yuen, Jr. (Medford, Massachusetts) |
| ABSTRACT | A method of forming a tissue. The method includes providing a source of a pre-tissue composition comprising endothelial cells. The method also includes perfusing a culture media into the pre-tissue composition using a plurality of primary channels and a plurality of secondary channels to form the tissue, wherein the endothelial cells are configured to form the secondary channels via vasculogenesis. |
| FILED | Thursday, February 18, 2021 |
| APPL NO | 17/904590 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) C12M 29/10 (20130101) C12M 41/14 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0691 (20130101) Original (OR) Class C12N 2521/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230091103 | Tohlen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| INVENTOR(S) | Michael Aaron Tohlen (Kansas City, Missouri); Mitchell Hedges Morrow (Kansas City, Missouri) |
| ABSTRACT | A computer-implemented method for compressing video data comprises receiving a sequence of video data values, each video data value being a digital value from a successive one of a plurality of pixels that form a video sensor, the sequence of video data values resulting from successive frames of video captured by the video sensor; extracting the video data values for each pixel in turn to create a plurality of pixel data streams, each pixel data stream including the video data value for each frame of captured video for the pixel; and applying data compression to each pixel data stream to create compressed data for each pixel data stream. |
| FILED | Friday, November 11, 2022 |
| APPL NO | 17/985403 |
| CURRENT CPC | Pictorial Communication, e.g Television H04N 19/132 (20141101) H04N 19/136 (20141101) H04N 19/172 (20141101) H04N 19/182 (20141101) H04N 19/184 (20141101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230091380 | Yu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Zhaoxin Yu (Richland, Washington); Dongping Lu (Richland, Washington) |
| ABSTRACT | Solid composite electrolytes include (i) an amorphous matrix comprising one or more lithiophilic elements and (ii) lithium-based electrolyte crystals at least partially embedded in the amorphous matrix, the lithium-based electrolyte crystals having a different chemical composition than the amorphous matrix. After the composite is compressed or cycled in a battery, a surface portion of the composite has a concentration of the lithiophilic element(s) that is greater than an average concentration of the lithiophilic element(s) in a bulk portion of the composite. |
| FILED | Thursday, September 15, 2022 |
| APPL NO | 17/945447 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/052 (20130101) H01M 10/0562 (20130101) Original (OR) Class H01M 2300/0068 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230091551 | Qu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Boning Qu (Ann Arbor, Michigan); Stephen R. FORREST (Ann Arbor, Michigan) |
| ABSTRACT | An organic light emitting device comprises an anode, a first hole transport layer positioned over the anode, a barrier transport layer positioned over the first hole transport layer, a second hole transport layer positioned over the barrier transport layer, at least one emissive layer positioned over the second hole transport layer, and a cathode positioned over the at least one emissive layer. |
| FILED | Thursday, September 22, 2022 |
| APPL NO | 17/934388 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/5004 (20130101) H01L 51/5096 (20130101) Original (OR) Class H01L 2251/558 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230091829 | Brost et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Randolph Brost (Albuquerque, New Mexico); Daniel E. Small (Albuquerque, New Mexico); David K. Novick (Albuquerque, New Mexico); Julius Yellowhair (Albuquerque, New Mexico) |
| ABSTRACT | Various embodiments may include collecting, by an unmanned aerial vehicle (UAV), a measuring image of an assessed heliostat in a heliostat field. The measuring image of the assessed heliostat includes an assessed facet forming a reflective surface of the assessed heliostat. At least a portion of a reference heliostat is visible in a reflection on the assessed facet. Also, a surface normal variance between a calculated surface normal of the assessed heliostat and a presumed surface normal of the assessed heliostat may be collected. The calculated surface normal is determined from a point on the assessed facet that corresponds to one or more features of the reference heliostat identifiable in the reflection. The presumed surface normal of the assessed heliostat may be updated based on the determined surface normal variance. |
| FILED | Thursday, September 15, 2022 |
| APPL NO | 17/945157 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/564 (20170101) Original (OR) Class G06T 2207/30184 (20130101) Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 40/22 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230091921 | Visco et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PolyPlus Battery Company (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven J. Visco (Berkeley, California); Yevgeniy S. Nimon (Danville, California); Bruce D. Katz (Moraga, California); Vitaliy Nimon (San Francisco, California); Dmytro Savytskyy (Vallejo, California) |
| ABSTRACT | An intermediary solid electrolyte structure having a Li ion conducting solid electrolyte layer covered with a thin as-deposited lithium phosphorus nitride film. |
| FILED | Tuesday, July 19, 2022 |
| APPL NO | 17/813463 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0562 (20130101) Original (OR) Class H01M 2300/0068 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230092166 | Young et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Barbara Diane Young (Raymore, Missouri); Steven James Sedlock (Raymore, Missouri); Gregory Layton Lane, JR. (Lee's Summit, Missouri); Kevin Christopher Ledden (Raymore, Missouri) |
| ABSTRACT | A system, device, and method for imparting or transferring a geometric pattern on the surface of a substrate. The device comprises, a housing forming at least a partially enclosed space, a light source body comprising an array of light emitters, a base disposed below the light source body and configured for supporting the substrate having a photoresist layer thereon, and a controller for activating a predetermined number of individual light emitters corresponding to the predetermined geometric pattern. Each individual light emitter within the array of light emitters is selectively activatable to emit a light. The array of light emitters comprises a plurality of light-emitting diodes, a plurality of quantum dots, or both. |
| FILED | Thursday, September 23, 2021 |
| APPL NO | 17/482992 |
| CURRENT CPC | Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/70008 (20130101) G03F 7/70275 (20130101) Original (OR) Class G03F 7/70575 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0274 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230092459 | Zhao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Haonan Zhao (Ann Arbor, Michigan); Claire Arneson (Ann Arbor, Michigan); Stephen R. FORREST (Ann Arbor, Michigan) |
| ABSTRACT | An organic light emitting device (OLED) comprises a substrate layer, a sub-electrode microlens array (SEMLA) at least partially embedded in the substrate layer comprising a plurality of microlenses, a first electrode layer over the substrate layer, a light emitting layer over the first electrode layer, and a second electrode layer over the light emitting layer. The device can further include a distributed Bragg reflector (DBR) layer between the substrate and first electrode layers and/or a Purcell Factor (PF) enhancement layer over the second electrode layer, comprising at least one layer pair including a silver mirror electrode and a metal-dielectric layer. Related methods are also disclosed. |
| FILED | Thursday, September 15, 2022 |
| APPL NO | 17/932475 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/5215 (20130101) H01L 51/5234 (20130101) H01L 51/5265 (20130101) H01L 51/5271 (20130101) H01L 51/5275 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230093228 | Schwede et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Spark Thermionics, Inc. (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jared William Schwede (Berkeley, California); Lucas Heinrich Hess (Berkeley, California) |
| ABSTRACT | A thermionic energy converter, preferably including an anode and a cathode. An anode of a thermionic energy converter, preferably including an n-type semiconductor, one or more supplemental layers, and an electrical contact. A method for work function reduction and/or thermionic energy conversion, preferably including inputting thermal energy to a thermionic energy converter, illuminating an anode of the thermionic energy converter, thereby preferably reducing a work function of the anode, and extracting electrical power from the system. |
| FILED | Wednesday, November 23, 2022 |
| APPL NO | 17/993195 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 45/00 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 35/14 (20130101) H01L 35/18 (20130101) H01L 35/22 (20130101) H01L 35/30 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230093592 | Rodriguez et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California); The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jennifer N. Rodriguez (Lathrop, California); Duncan J. Maitland (College Station, Texas); Thomas S. Wilson (San Leandro, California) |
| ABSTRACT | Polymeric based closed cell foams, such as shape memory polymer foams, contain bubbles. Making these bubbles continuous is called reticulation. Disclosed are embodiments of a device and method to controllably reticulate polymer-based closed cell foams by puncturing the membranes of these polymer-based closed cell foams. |
| FILED | Monday, October 31, 2022 |
| APPL NO | 17/977345 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 31/06 (20130101) A61L 31/146 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 44/5663 (20130101) Original (OR) Class Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2075/00 (20130101) Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 5/18 (20130101) B32B 5/32 (20130101) B32B 2266/08 (20130101) B32B 2266/0278 (20130101) B32B 2535/00 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/73 (20130101) C08G 18/3228 (20130101) C08G 18/3278 (20130101) C08G 18/3284 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 9/38 (20130101) C08J 2205/052 (20130101) C08J 2207/10 (20130101) C08J 2375/04 (20130101) Compositions of Macromolecular Compounds C08L 75/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230093741 | LOYCHIK |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Triad National Security, LLC (Los Alamos, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Neil Edward LOYCHIK (Los Alamos, New Mexico) |
| ABSTRACT | A signal processing method and apparatus quantifies signal “character” in the frequency domain from highly complex signals in a statistically consistent manner. Particular aspects focus on spectral density analyses such as skewness spectral density (SSD), kurtosis spectral density KSD), and probability spectral density (PDSD), among other types of spectral density. Applications of the inventive technique enable not only identification of signal characteristics, but also quantification of signal behavior in an explainable way. Higher orders of spectral densities are 1) physical and statistical, 2) convergent with boundable error, 3) integrable and relatable to the time-domain, and 4) typically differentiable. |
| FILED | Monday, September 19, 2022 |
| APPL NO | 17/947966 |
| CURRENT CPC | Measurement of Mechanical Vibrations or Ultrasonic, Sonic or Infrasonic Waves G01H 1/003 (20130101) Original (OR) Class Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 1/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20230086022 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Liping Wang (Chandler, Arizona); Linshuang Long (Hefei, China PRC); Sydney Taylor (Charlestown, Rhode Island) |
| ASSIGNEE(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| INVENTOR(S) | Liping Wang (Chandler, Arizona); Linshuang Long (Hefei, China PRC); Sydney Taylor (Charlestown, Rhode Island) |
| ABSTRACT | A layered thermochromic device for enhanced infrared emission, and method for creating the same is disclosed. The method includes deposing a spacer layer of HfO2 upon a metallic layer, spin coating the spacer layer with photoresist, exposing the photoresist with a photomask, creating a plurality of holes in the photoresist, and deposing vanadium on the photoresist and the plurality of holes, filling the holes and forming vanadium microdisks on the spacer layer. The method also includes removing the photoresist and the vanadium deposed on the photoresist, and forming a thermochromic layer having VO2 coupled to the spacer layer through direct oxidation of the deposed vanadium microdisks by heating the device in a furnace under a nitrogen/oxygen flow. The device includes a metallic layer, a spacer layer coupled to the metallic layer, and a thermochromic layer deposed on the spacer layer opposite the metallic layer. |
| FILED | Thursday, June 02, 2022 |
| APPL NO | 17/831160 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 5/208 (20130101) Original (OR) Class Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/0005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230086952 | Green et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Matthew Green (Phoenix, Arizona); Yi Yang (Mesa, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Green (Phoenix, Arizona); Yi Yang (Mesa, Arizona) |
| ABSTRACT | A zwitterionic polysulfone formed from an allyl-containing monomer, a phenol-containing monomer, and an aryl-halide-containing monomer. The zwitterionic polysulfone may be incorporated into a desalination membrane. |
| FILED | Friday, November 11, 2022 |
| APPL NO | 17/985288 |
| CURRENT CPC | Separation B01D 71/68 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/44 (20130101) C02F 2103/08 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 75/23 (20130101) Original (OR) Class Compositions of Macromolecular Compounds C08L 81/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230091751 | VELAZCO |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jose E. VELAZCO (Altadena, California) |
| ABSTRACT | Multiple-link optical terabit terminals (MLOTT) allowing high speed data transfer rates in terabit per second range in an omnidirectional fashion are disclosed. The described terminals have multifaceted structure, provide full coverage, implement single laser or laser arrays, and single detector or detector arrays to achieve higher transmission rates. Wavelength division multiplexing schemes can also be used when implementing the disclosed terminals for higher data rates. Steerable mirrors and lenses can be implemented as part of the terminals and based on angle-of-arrival calculations performed in real time. |
| FILED | Wednesday, August 24, 2022 |
| APPL NO | 17/894847 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 26/0816 (20130101) G02B 26/0875 (20130101) Transmission H04B 10/29 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230092893 | Lee |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States of America as represented by the Administrator of NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan A. Lee (Madison, Alabama) |
| ABSTRACT | An ultraviolet germicidal door handle includes a germicidal ultraviolet light source mounted at an end of the door handle that includes a capacitive or other MEMS sensor(s) which detects a user's touch or movement operation and initiates activation and timing operation of the ultraviolet germicidal light source. Ultraviolet germicidal light emitted from the light source is directed as a column along a circumferential length of the door handle, thereby providing a germicidal action/effect on all touching surfaces of the door handle. |
| FILED | Wednesday, September 22, 2021 |
| APPL NO | 17/482109 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 2/10 (20130101) A61L 2/24 (20130101) A61L 2202/11 (20130101) A61L 2202/14 (20130101) Locks; Accessories Therefor; Handcuffs E05B 1/0069 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230092901 | Mondry et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jack Mondry (Edina, Minnesota); Shane Farritor (Lincoln, Nebraska); Eric Markvicka (Brush, Colorado); Thomas Frederick (Lincoln, Nebraska); Joe Bartels (Pittsburgh, Pennsylvania) |
| ABSTRACT | Disclosed herein are various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices. Also disclosed are various medical devices for in vivo medical procedures. Included herein, for example, is a surgical robotic device having an elongate device body, a right robotic arm coupled to a right shoulder assembly, and a left robotic arm coupled to a left shoulder assembly. |
| FILED | Monday, November 28, 2022 |
| APPL NO | 18/058904 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/00234 (20130101) A61B 34/20 (20160201) A61B 34/30 (20160201) Original (OR) Class A61B 90/361 (20160201) A61B 2017/2906 (20130101) Manipulators; Chambers Provided With Manipulation Devices B25J 9/0084 (20130101) B25J 9/0087 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230092997 | Mody et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | A10 Systems LLC (Chelmsford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Apurva N. Mody (Chelmsford, Massachusetts); Bryan Crompton (Lowell, Massachusetts); Junaid Islam (San Jose, California); David Simpson (Springfield, Virginia); Dap Minh Tran (Lowell, Massachusetts); Tommaso Melodia (Newton, Massachusetts) |
| ABSTRACT | A method of dynamically routing packets to a destination node performed by a computing device is disclosed. The method includes: (1) detecting a status of a plurality of links to the destination node across a plurality of communications modalities; (2) determining a set of links to use for routing packets to the destination node based on the detected statuses; and (3) sending packets to the destination node via the determined set of links. A related computer program product, apparatus, and system are also disclosed. |
| FILED | Monday, September 19, 2022 |
| APPL NO | 17/933452 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 43/08 (20130101) H04L 47/29 (20130101) Original (OR) Class H04L 47/30 (20130101) H04L 47/2433 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20230088895 | Cheeran et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Maxim Chacko-Joseph Cheeran (Apple Valley, Minnesota); Venkatramana Divana Krishna Bhat (St. Paul, Minnesota); Maria Graciela Pieters Silva (Arden Hills, Minnesota) |
| ABSTRACT | Antibodies that detect M. hyopneumoniae, methods of making those antibodies, and methods of using those antibodies including, for example, in a diagnostic immunoassay, are described. Such a diagnostic assay may be used in pen-side testing for detection of M. hyopneumoniae. |
| FILED | Wednesday, September 14, 2022 |
| APPL NO | 17/944312 |
| CURRENT CPC | Peptides C07K 16/1253 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/33 (20130101) C07K 2317/565 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56933 (20130101) G01N 2469/10 (20130101) G01N 2470/04 (20210801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230089653 | Ozias-Akins et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (Athens, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peggy Ozias-Akins (Tifton, Georgia); Joann A. Conner (Tifton, Georgia) |
| ABSTRACT | Methods and compositions disclosed herein relate to genes involved in plant production and methods of using the same. |
| FILED | Tuesday, July 12, 2022 |
| APPL NO | 17/812022 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8287 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20230087020 | March et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida); University of Notre Dame du Lac (South Bend, Indiana) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida); University of Notre Dame du Lac (South Bend, Indiana) |
| INVENTOR(S) | Keith L. March (Gainesville, Florida); Dmitry Olegovich Traktuev (Gainesville, Florida); Pinar Zorlutuna (Notre Dame, Indiana); Bradley Ellis (Notre Dame, Indiana) |
| ABSTRACT | Provided herein are compositions and methods related to extending viable preservation of organs and tissues. The compositions comprise superoxide dismutase, catalase, vitamin E, and glutathione, and optionally, a preservation solution (e.g., University of Wisconsin solution). Also provided are methods of preserving the contractile function of a contractile tissue, as well as kits comprising the compositions described herein. |
| FILED | Wednesday, March 10, 2021 |
| APPL NO | 17/909067 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0226 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230093117 | STEINBRINK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | Duke University (Durham, North Carolina); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| INVENTOR(S) | Julie STEINBRINK (Durham, North Carolina); Micah MCCLAIN (Durham, North Carolina); David CORCORAN (Durham, North Carolina); Jennifer MODLISZEWSKI (Durham, North Carolina); Marisol BETANCOURT-QUIROZ (Durham, North Carolina); Aimee ZAAS (Durham, North Carolina) |
| ABSTRACT | The present disclosure describes systems, methods, kits, and devices for detecting and treating a fungal infection in a subject. In particular, provided herein are host gene markers that can be used for identifying and treating an Aspergillus infection. The methods, devices, kits, and systems disclosed herein are used to classify subjects based on the expression levels of the identified gene markers. In some embodiments, the Aspergillus infection comprises an infection with Aspergillus fumigatus. |
| FILED | Tuesday, February 23, 2021 |
| APPL NO | 17/801724 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6844 (20130101) C12Q 1/6895 (20130101) Original (OR) Class C12Q 2600/112 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20230087031 | Bolha et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rosemarie Bolha (Wilkes-Barre, Pennsylvania); Stephen M. Dearing (Herndon, Virginia) |
| ABSTRACT | Systems and methods for tracking items. A system for tracking an item is configured to scan the item for a computer readable code and convert the computer readable code into a digital identifier associated with the item. The system includes a controller circuit configured to receive authentication information from the mobile computing device, receive a request from the mobile computing device, comprising the digital identifier and a request for information relating to the item. When the memory has the information, the controller circuit obtains the information from the memory and generates an output comprising the digital identifier and the information for display. The output is based on a comparison of a location of the mobile computing device and an expected location of the item. |
| FILED | Wednesday, November 30, 2022 |
| APPL NO | 18/060261 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 7/1413 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/087 (20130101) Original (OR) Class G06Q 10/0833 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/08 (20130101) Wireless Communication Networks H04W 12/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230091390 | Irwin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Donald E. Irwin (Fredericksburg, Virginia); Nan K. McKenzie (Garrett Park, Maryland); William A. Tartal (Baltimore, Maryland); Victoria K. Stephen (Burke, Virginia); Michael J. Amato (Reston, Virginia); William G. Ackerman (Washington, District of Columbia); Robert E. Dixon (Washington, District of Columbia); Daniel W. Smith (Washington, District of Columbia); Gregory Crabb (Broadlands, Virginia); Paul Anthony Bernicchi (Land O Lakes, Florida) |
| ABSTRACT | A system and method of verifying the identity of a user or registrant. The user or registrant provides identification information and registration information. The identification information may be a visual representation of an identifying item associated with location information. In some embodiments, the identification information may be a visual representation of a government issued identity. An identification module verifies the identification information and compares the verified identification information to the registration information. |
| FILED | Monday, November 21, 2022 |
| APPL NO | 18/057438 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 20/405 (20130101) G06Q 20/4014 (20130101) G06Q 30/0185 (20130101) G06Q 50/265 (20130101) Original (OR) Class Image or Video Recognition or Understanding G06V 30/418 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20230087700 | Hersam et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark C. Hersam (Wilmette, Illinois); Woo Jin Hyun (Evanston, Illinois) |
| ABSTRACT | One aspect of this invention relates to hexagonal boron nitride (hBN) ionogel inks using exfoliated hBN nanoplatelets as the solid matrix. The hBN nanoplatelets are produced from bulk hBN powders by liquid-phase exfoliation, allowing printable hBN ionogel inks to be formulated following the addition of an imidazolium ionic liquid and ethyl lactate. The resulting inks are reliably printed with variable patterns and controllable thicknesses by aerosol jet printing, resulting in hBN ionogels that possess high room-temperature ionic conductivities and storage moduli of >3 mS cm-1 and >1 MPa, respectively. By integrating the hBN ionogel with printed semiconductors and electrical contacts, fully-printed thin-film transistors with operating voltages below 1 V are demonstrated on polyimide films. These devices exhibit desirable electrical performance and robust mechanical tolerance against repeated bending cycles, thus confirming the suitability of hBN ionogels for printed and flexible electronics. |
| FILED | Thursday, January 28, 2021 |
| APPL NO | 17/798618 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/033 (20130101) C09D 11/52 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20230085933 | DiCicco et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Joseph A. DiCicco (Cape Mary Court, New Jersey); Andrew Horan (Mays Landing, New Jersey); John Brady (Medford, New Jersey) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Joseph A. DiCicco (Cape Mary Court, New Jersey); Andrew Horan (Mays Landing, New Jersey); John Brady (Medford, New Jersey) |
| ABSTRACT | A media holder can be used for preparing samples. The media holder can comprise a base, a pair of walls extending upwardly from the base, and a plurality of transverse members positioned on and coupled to a respective upper end of each of the walls. Each of the transverse members can define a receiving slot for receiving at least a portion of a media therein. |
| FILED | Tuesday, September 20, 2022 |
| APPL NO | 17/948689 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 9/523 (20130101) Original (OR) Class B01L 2200/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Security Agency (NSA)
| US 20230087217 | SOHANGHPURWALA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Graf Research Corporation (Blacksburg, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ali Asgar SOHANGHPURWALA (Decatur, Georgia); Scott HARPER (Blacksburg, Virginia); Jonathan GRAF (Blacksburg, Virginia); Carlton FRALEY (Christiansburg, Virginia); Alan COOK (Christiansburg, Virginia); Timothy DUNHAM (Roanoke, Virginia) |
| ABSTRACT | A computer system traces an original electronic design automation (EDA) implementation process for electronic hardware designs. The original EDA implementation process includes multiple subprocesses to convert a hardware model to a physically-realized electronic circuit. The system inputs a cryptographic key and design information that includes the hardware model, constraints, properties, implementation settings, and other directives for directing the conversion. The cryptographic key and design information are processed to generate a sequence of instructions to execute and provide traceability of each subprocess. For each subprocess, the system gathers intermediate design state and implementation settings resulting from or influencing execution of the subprocess; combines the intermediate design state and implementation settings into a data string and determines a cryptographic hash value for the data string; digitally signs the cryptographic hash value using a digital signature certificate derived from the cryptographic key to generate a signed hash; stores the signed hash and identifiers associated with data files used for determining the cryptographic hash value to an electronic ledger to generate an updated electronic ledger; authenticates the signed hash from the electronic ledger to generate an authenticated signed hash; reconstructs a hash from the data files stored in the electronic ledger to generate a reconstructed hash; compares the authenticated signed hash with the reconstructed hash, and in response to a mismatch, generates an error signal. The steps are repeated for each subsequent subprocess, and the traced EDA implementation process results are stored in memory. |
| FILED | Thursday, September 22, 2022 |
| APPL NO | 17/950341 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/31 (20200101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/50 (20220501) Original (OR) Class H04L 9/3247 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Non-Profit Organization (NPO)
| US 20230092795 | Angelini et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas Ettor Angelini (Gainesville, Florida); Brent S. Sumerlin (Gainesville, Florida); Christopher S. O'Bryan (Gainesville, Florida); Georg Scheutz (Gainesville, Florida) |
| ABSTRACT | Described herein are compositions, methods, kits, and systems relating to smooth, spherical microgels which can be charge-neutral. The microgels can be made using an emulsification process. In certain aspects, charge-neutral microgels as described herein are suitable for 3D cell culture, use in perfusion bioreactors, and/or 3D printing of cells for 3D cell culture. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/802686 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 70/00 (20141201) Apparatus for Enzymology or Microbiology; C12M 25/18 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0062 (20130101) Original (OR) Class C12N 2533/30 (20130101) C12N 2537/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20230087043 | Mancebo |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ricardo Mancebo (Fremont, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ricardo Mancebo (Fremont, California) |
| ABSTRACT | The invention relates to the amplification of specific target nucleic acids. The invention provides methods, reagents, and kits for carrying out such amplification via the autoligation chain reaction (ACR). |
| FILED | Monday, May 02, 2022 |
| APPL NO | 17/734226 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6853 (20130101) Original (OR) Class C12Q 1/6862 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20230093006 | Scott et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | COM DEV Ltd. (Mississauga, Canada) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alan Scott (Arnprior, Canada); Hugh Podmore (Toronto, Canada) |
| ABSTRACT | Various embodiments are disclosed herein with generally relate to an optical communication system using a photonic lantern. In at least one embodiment, the optical system comprises: an optical transmitter coupled to a signal transmitting path; an optical receiver coupled to a signal receiving path; a photonic lantern, the photonic lantern extending between a first open end and a second open end, the first end comprising an opening to a single multi-mode fiber, and the second end comprising a plurality of single mode fibers that are adiabatically coupled to the multi-mode fiber, the plurality of single-mode fibers includes a single-mode fiber adapted to carry a fundamental optical mode and the remaining single-mode fibers adapted to carry higher-order optical modes, wherein, the single-mode fiber is coupled to the optical transmitting path, the remaining single-mode fibers are coupled to the optical receiving path. |
| FILED | Friday, September 17, 2021 |
| APPL NO | 17/478627 |
| CURRENT CPC | Transmission H04B 10/25 (20130101) Original (OR) Class H04B 10/294 (20130101) H04B 10/506 (20130101) Multiplex Communication H04J 14/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, March 23, 2023.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20230323.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page