FedInvent™ Patent Applications
Application Details for Thursday, March 30, 2023
This page was updated on Thursday, March 30, 2023 at 11:35 AM GMT
Department of Health and Human Services (HHS)
| US 20230093812 | ROSEN et al. |
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| FUNDED BY |
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| APPLICANT(S) | BARRY P. ROSEN (BOYNTON BEACH, Florida); MASAFUMI YOSHINAGA (DORAL, Florida); STANISLAW F. WNUK (MIAMI, Florida); MD ABU HASAN HOWLADER (MIAMI, Florida); SK MD SAZZAD HOSSAIN SUZOL (PHILADELPHIA, Pennsylvania) |
| ASSIGNEE(S) | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (MIAMI, Florida) |
| INVENTOR(S) | BARRY P. ROSEN (BOYNTON BEACH, Florida); MASAFUMI YOSHINAGA (DORAL, Florida); STANISLAW F. WNUK (MIAMI, Florida); MD ABU HASAN HOWLADER (MIAMI, Florida); SK MD SAZZAD HOSSAIN SUZOL (PHILADELPHIA, Pennsylvania) |
| ABSTRACT | The subject invention provides methods for the chemical synthesis of racemic arsinothricin (D,L-AST), the novel organoarsenical antibiotic. One is by condensation of the 2-chloroethyl(methyl)arsinic acid with acetamidomalonate, and the second involves reduction of the N-acetyl-protected derivative of hydroxyarsinothricin (AST-OH) and subsequent methylation of the resulting sodium salt of trivalent arsenic intermediate with methyl iodide. The enzyme AST N-acetyltransferase (ArsN1) was utilized to purify L-AST from racemic AST. This expedient chemical synthesis of AST provides a source of this novel antibiotic for future drug development. |
| FILED | Monday, December 05, 2022 |
| APPL NO | 18/074835 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/72 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230093831 | Kim et al. |
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| FUNDED BY |
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| APPLICANT(S) | OBSIDIO, INC. (COLUMBIA, South Carolina) |
| ASSIGNEE(S) | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (ROCHESTER, New York); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Hanjun Kim (Los Angeles, California); Chun Xu (Los Angeles, California); Ehsan Jabbarzadehhereby (Columbia, South Carolina); Rahmi Oklu (Chandler, Arizona); Alireza Khadembosseini (Los Angeles, California) |
| ABSTRACT | We have developed novel shear-thinning biomaterials using silica nanoparticles, gelatin-based polymers and small molecules such as doxorubicin. Shear-thinning biomaterial technology offers enables polymers and drugs loaded inside such polymers to be easily delivered directly through catheters into target area for use, for example, in cancer therapy and immunotherapy. When a force above a certain threshold is applied to inject such materials, they “thin” and behaves as a semi-solid, allowing the material to readily flow through a catheter. When the force is removed, the material instantly becomes a soft solid with significant cohesive properties that prevent it from dislodging or breaking up. |
| FILED | Thursday, September 29, 2022 |
| APPL NO | 17/956701 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/5115 (20130101) A61K 31/704 (20130101) Original (OR) Class A61K 47/42 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230093888 | QUIJANO et al. |
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| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | Yale University (New Haven, Connecticut) |
| INVENTOR(S) | Elias QUIJANO (Durham, Connecticut); Peter GLAZER (Guilford, Connecticut) |
| ABSTRACT | Compositions and methods of use thereof for delivering nucleic acid cargo into cells are provided. The compositions typically include (a) a 3E10 monoclonal antibody or an antigen binding, cell-penetrating fragment thereof; a monovalent, divalent, or multivalent single chain variable fragment (scFv); or a diabody; or humanized form or variant thereof, and (b) a nucleic acid cargo including, for example, a nucleic acid encoding a polypeptide, a functional nucleic acid, a nucleic acid encoding a functional nucleic acid, or a combination thereof. Elements (a) and (b) are typically non-covalently linked to form a complex. |
| FILED | Tuesday, August 30, 2022 |
| APPL NO | 17/823494 |
| CURRENT CPC | Peptides C07K 14/52 (20130101) C07K 14/4747 (20130101) C07K 16/44 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/31 (20130101) C07K 2317/565 (20130101) C07K 2319/33 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230093891 | Streets et al. |
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| FUNDED BY |
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| APPLICANT(S) | CHAN ZUCKERBERG BIOHUB, INC. (San Francisco, California); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aaron Streets (Oakland, California); Tyler Chen (Oakland, California); Anushka Gupta (Oakland, California) |
| ABSTRACT | The present disclosure provides materials and methods to link imaging and sequencing measurements of a single cell. Sequencing information can be linked with phenotypic measurements that are not directly encoded in the genome such as morphological features, protein expression & localization, organelle dynamics, or the metabolic composition of a cell. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/798501 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6869 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230094016 | Kim et al. |
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| FUNDED BY |
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| APPLICANT(S) | OBSIDIO, INC. (COLUMBIA, South Carolina) |
| ASSIGNEE(S) | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (ROCHESTER, New York); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Hanjun Kim (Los Angeles, California); Wujin Sun (Los Angeles, California); Ehsan Jabbarzadeh (Columbia, South Carolina); Rahmi Oklu (Chandler, Arizona); Alireza Khademhosseini (Los Angeles, California) |
| ABSTRACT | We have developed novel shear-thinning biomaterials using silica nanoparticles, gelatin-based polymers and polypeptides such as anti-PD-1 antibodies. Shear-thinning biomaterial technology offers enables polymers and drugs loaded inside such polymers to be easily delivered directly through catheters into target area for use, for example, in cancer therapy and immunotherapy. When a force above a certain threshold is applied to inject such materials, they “thin” and behaves as a semi-solid, allowing the material to readily flow through a catheter. When the force is removed, the material instantly becomes a soft solid with significant cohesive properties that prevent it from dislodging or breaking up. |
| FILED | Thursday, September 29, 2022 |
| APPL NO | 17/956644 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5115 (20130101) A61K 9/5169 (20130101) A61K 47/6933 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230094152 | Shivaei et al. |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
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| INVENTOR(S) | Shirin Shivaei (Pasadena, California); Mikhail G. Shapiro (Pasadena, California) |
| ABSTRACT | Disclosed herein include methods, compositions, and kits suitable for use in imaging of in situ gene expression. There are provided, in some embodiments, viral vector compositions. Disclosed herein includes a single viral vector comprising one or more gas vesicle assembly (GVA) gene(s) encoding one or more GVA protein(s), and one or more gas vesicle structural (GVS) gene(s) encoding one or more GVS protein(s). The one or more GVA protein(s) and the one or more GVS protein(s) can be capable of forming gas vesicles (GVs) upon expression in a cell. |
| FILED | Wednesday, September 28, 2022 |
| APPL NO | 17/936286 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/08 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 15/635 (20130101) C12N 2740/15043 (20130101) C12N 2740/15045 (20130101) C12N 2740/15071 (20130101) C12N 2840/002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230094597 | Cao |
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| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
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| INVENTOR(S) | Xu Cao (Baltimore, Maryland) |
| ABSTRACT | Provided herein are compositions and methods directed to treating, delaying progression of, or reducing cancer growth or metastasis, and the severity of disorders characterized with increased osteoclast activity through hindering and/or inhibiting osteoclastogenesis and/or osteoclast activity. In particular, the present invention provides compositions and methods directed to hindering and/or inhibiting Siglec15 and sialylated TLR (e.g., TLR2, TLR4) interaction by specific sialyltransferases. |
| FILED | Friday, September 23, 2022 |
| APPL NO | 17/934937 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/47 (20130101) Original (OR) Class A61K 39/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/08 (20180101) Peptides C07K 16/2875 (20130101) C07K 2317/21 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230094625 | Yang et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| INVENTOR(S) | Cheng Yang (Lexington, Massachusetts); B. Jill Venton (Charlottesville, Virginia) |
| ABSTRACT | An electrochemical device for identifying electroactive analytes. The device includes a substrate; a sample region; a counter electrode; a reference electrode; a working electrode disposed in communication with the substrate, and the working electrode may be an electron conducting fiber. Further, the counter electrode, reference electrode, and working electrode are partially disposed in the sample region configured to be exposed to the electroactive analyte. Further yet, a counter electrode channel, reference electrode channel, and working electrode channel are disposed in the substrate configured to: accommodate each of the counter electrode, reference electrode, and working electrode, respectively, for placement in the respective channels. |
| FILED | Thursday, June 23, 2022 |
| APPL NO | 17/847532 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) B82Y 15/00 (20130101) B82Y 40/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/327 (20130101) G01N 27/3278 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0048 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230094737 | PURSE et al. |
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| FUNDED BY |
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| APPLICANT(S) | San Diego State University Research Foundation (San Diego, California) |
| ASSIGNEE(S) | San Diego State University Research Foundation (San Diego, California) |
| INVENTOR(S) | Byron W. PURSE (San Diego, California); Dillon BURNS (San Diego, California); Kristine TEPPANG (San Diego, California); Raymond LEE (San Diego, California); Melissa LOKENSGARD (San Diego, California) |
| ABSTRACT | Herein reported are new tricyclic cytidine compounds, such as 8-diethylamino-tC (8-DEA-tC), that respond to DNA and/or RNA duplex formation with up to a 20-fold increase in fluorescent quantum yield as compared with the free nucleoside, depending on neighboring bases. This turn-on response to duplex formation is by far the greatest of any reported nucleoside analogue that can participate in Watson-Crick base pairing. Measurements of the quantum yield of 8-DEA-tC mispaired with adenosine and, separately, opposite an abasic site show that there is almost no fluorescence increase without the formation of correct Watson-Crick hydrogen bonds. Kinetic isotope effects from the use of deuterated buffer show that the duplex protects 8-DEA-tC against quenching by excited state proton transfer. DFT calculations provide a rationale for the observed photophysical properties that is dependent on duplex integrity and the electronic structure of the analogue. |
| FILED | Tuesday, September 13, 2022 |
| APPL NO | 17/943682 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 19/24 (20130101) Original (OR) Class Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) C09K 2211/1018 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/682 (20130101) C12Q 1/686 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/77 (20130101) G01N 2021/7786 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230094869 | Rivnay et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
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| INVENTOR(S) | Jonathan Rivnay (Chicago, Illinois); Reem B. Rashid (Chicago, Illinois); Robert J. Ciechowski (Glendale Heights, Illinois) |
| ABSTRACT | Cofacial vertical organic electrochemical transistor (vOECT) pairs, electronic circuits into which the vOECT pairs are integrated, and methods for fabricating the vOECT pairs are provided. The vOECTs pairs are formed from a vertically stacked structure that includes a first layer of an electrically conducting material, a first layer of an electrically insulating material, and a second layer of an electrically conducting material. The vOECTs of the pairs are formed on opposing sidewalls of a trench formed in the stacked structure. |
| FILED | Friday, March 05, 2021 |
| APPL NO | 17/907852 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/414 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/057 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230094870 | SHABAT et al. |
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| APPLICANT(S) | Ramot at Tel-Aviv University Ltd. (Tel Aviv, Israel); The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
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| INVENTOR(S) | Doron SHABAT (Tel Aviv, Israel); Ori GREEN (Tel Aviv, Israel); Matthew BOGYO (Redwood City, California) |
| ABSTRACT | Turn-ON dioxetane-based chemiluminescence probes based on the Schapp's adamantylidene-dioxetane probe eh are useful for determining the presence, or measuring the level, of Mycobacterium tuberculosis (Mtb)-specific protease in a sample, and for assessing the susceptibility of the Mtb to an antibiotic drug. determining the presence or measuring the level of Mycobacterium tuberculosis (Mtb)-specific protease in the sample can include contacting the sample with a certain compound, and imaging the sample to detect an emission of light. |
| FILED | Wednesday, February 17, 2021 |
| APPL NO | 17/904527 |
| CURRENT CPC | Heterocyclic Compounds C07D 321/00 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/04 (20130101) C12Q 1/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230095032 | Horenstein et al. |
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| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
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| INVENTOR(S) | Nicole Alana Horenstein (High Springs, Florida); Roger Lee Papke (Gainesville, Florida); Hina Andleeb (Boston, Massachusetts) |
| ABSTRACT | Provided are embodiments of para-substituted 1,1-dialkyl-4-phenylpiperazin-1-ium iodides advantageous for modulating inflammation that have been synthesized and their electrophysiology activities for α9, α9α10, and α7 nAChRs compared. The para position contained alkyl or aryl amides, or heterocyclic isosteres for the amide, and the alkyl groups were varied at the ammonium piperazine nitrogen to see if compensatory changes in size at this position of the molecule impacted function. The compounds were characterized with two-electrode voltage-clamp measurements on Xenopus oocytes expressing nAChRs. General, the compounds were more potent for α9-containing receptors than for α7, and the majority were either full or strong partial agonists for α9-containing nAChR. |
| FILED | Tuesday, September 06, 2022 |
| APPL NO | 17/903735 |
| CURRENT CPC | Heterocyclic Compounds C07D 213/56 (20130101) Original (OR) Class C07D 263/32 (20130101) C07D 295/116 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230095034 | Yeager et al. |
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| APPLICANT(S) | Mezzion Pharma Co., Ltd. (Seoul, South Korea); Children's Hospital of Philadelphia (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Yeager (Lake Forest, Illinois); David J. Goldberg (Philadelphia, Pennsylvania); Stephen M. Paridon (Strafford, Pennsylvania) |
| ABSTRACT | The present invention relates generally to the field of using udenafil or a pharmaceutically acceptable salt thereof in patients who have undergone the Fontan operation. |
| FILED | Monday, September 14, 2020 |
| APPL NO | 17/020674 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/00 (20130101) A61K 31/519 (20130101) A61K 31/522 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/00 (20180101) Heterocyclic Compounds C07D 487/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230095192 | STETSON et al. |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Brewster STETSON (Seattle, Washington); Katelyn BURLEIGH (Seattle, Washington); Emily SCHUTSKY (Seattle, Washington) |
| ABSTRACT | Polynucleotide constructs are disclosed, that are potent activators of a STING-independent DNA sensing pathway (SIDSP), in which the DNA damage response protein DNA-PK is the sensor of the SIDSP, along with tire heat shock protein HSPA8 as a unique SIDSP target. The polynucleotide constructs of the disclosure are also potent activators of the cGAS-STING DNA sensing pathway. These pathways arm key components of the innate immune response that is important for antiviral immunity, contributes to specific autoimmune diseases, and mediate important aspects of antitumor immunity. |
| FILED | Monday, March 01, 2021 |
| APPL NO | 17/759210 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/02 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/117 (20130101) Original (OR) Class C12N 2310/17 (20130101) C12N 2310/52 (20130101) C12N 2310/315 (20130101) C12N 2310/332 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230095339 | Cleland-Huang et al. |
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| APPLICANT(S) | University of Notre Dame du Lac (South Bend, Indiana) |
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| INVENTOR(S) | Jane Cleland-Huang (South Bend, Indiana); Ankit Agrawal (South Bend, Indiana) |
| ABSTRACT | A method for sharing a point-of-interest across a plurality of video feeds from a plurality of optical imaging devices includes receiving an indication of the point-of-interest associated with a first video feed of the plurality of video feeds, the first video feed provided by a first optical imaging device of the plurality of optical imaging devices; determining a geo-location of an object associated with the point-of-interest; determining a position of a second optical imaging device relative to the determined geo-location of the point-of-interest; and overlaying the point-of-interest on a second video feed, the second video feed provided by the second optical imaging device. |
| FILED | Thursday, September 29, 2022 |
| APPL NO | 17/936648 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 39/024 (20130101) B64C 2201/126 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/0038 (20130101) G05D 1/104 (20130101) Electric Digital Data Processing G06F 3/0488 (20130101) Image Data Processing or Generation, in General G06T 15/06 (20130101) G06T 19/006 (20130101) Original (OR) Class G06T 2219/024 (20130101) Image or Video Recognition or Understanding G06V 20/17 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230095371 | Machielse et al. |
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| APPLICANT(S) | Mandos LLC (West Hollywood, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bernardus Nicolaas Machielse (North Potomac, Maryland); Allan Darling (North Potomac, Maryland) |
| ABSTRACT | This disclosure provides mixtures of beta-cyclodextrin molecules substituted at one or more hydroxyl positions by hydroxypropyl groups, the mixture optionally including unsubstituted beta-cyclodextrin molecules, for use as a pharmaceutically active ingredient; methods of making such mixtures; methods of qualifying such mixtures for use in a pharmaceutical composition suitable for intrathecal or intracerebroventricular administration; pharmaceutical compositions suitable for intrathecal or intracerebroventricular administration comprising such mixtures; and methods of using the pharmaceutical compositions for treatment of Niemann-Pick disease Type C. |
| FILED | Wednesday, November 30, 2022 |
| APPL NO | 18/072260 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/08 (20130101) A61K 9/0019 (20130101) A61K 9/0085 (20130101) A61K 31/724 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230095509 | Wood et al. |
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| FUNDED BY |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Kevin Wood (Minneapolis, Minnesota); Jonathan N. Sachs (St. Paul, Minnesota); Nagamani Vunnam (Minneapolis, Minnesota); Chih Hung Lo (Singapore, Singapore) |
| ABSTRACT | Provided herein are deoxygenated sickle hemoglobin (HbS), at concentrations far below the threshold for nucleation and rapid polymerization, that form small temporally stable assemblies of multiple α2β2 tetramers. Also provided are methods for making and detecting the small temporally stable assemblies and methods for identifying compounds that alter the structure of the small temporally stable assemblies. |
| FILED | Tuesday, September 27, 2022 |
| APPL NO | 17/953981 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 33/721 (20130101) Original (OR) Class G01N 2021/6439 (20130101) G01N 2800/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230095707 | CHEUNG et al. |
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| FUNDED BY |
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| APPLICANT(S) | Memorial Sloan Kettering Cancer Center (New York, New York); Cornell Univesity (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nai-Kong V. CHEUNG (New York, New York); Steven M. LARSON (New York, New York); Sarah CHEAL (New York, New York); Richard TING (Ithaca, New York); Hari Krishna KOMMIDI (Ithaca, New York); Feifei AN (Ithaca, New York); Brian SANTICH (New York, New York) |
| ABSTRACT | The present disclosure provides compositions and methods for the detection, and treatment of cancer. Specifically, the compositions of the present technology include multimodal fluorine-cyanine-DOTA-hapten compositions that may be complexed with a radioisotope (e.g., 175Lu). Also disclosed herein are methods of using the fluorine-cyanine-DOTA-hapten compositions of the present technology in diagnostic imaging as well as pretargeted radioimmunotherapy. |
| FILED | Wednesday, December 30, 2020 |
| APPL NO | 17/790079 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/0032 (20130101) A61K 49/0054 (20130101) A61K 51/0482 (20130101) Original (OR) Class A61K 51/0495 (20130101) A61K 51/0497 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/32 (20130101) C07K 16/44 (20130101) C07K 16/3084 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230096187 | Ziegler et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregory Ray Ziegler (State College, Pennsylvania); Joshua David Lambert (State College, Pennsylvania); Emmanuel Hatzakis (Columbus, Ohio); Eugene P. Mazzola (Vienna, Virginia) |
| ABSTRACT | The present invention provides compounds isolated from avocado seeds for use as a natural colorant in edible materials. The compounds of the invention are useful for coloring edible materials red, orange, or yellow. The invention also provides compositions and methods for coloring edible materials to a desired color such as red, orange, or yellow. |
| FILED | Tuesday, November 22, 2022 |
| APPL NO | 18/058118 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 59/82 (20130101) C07C 2603/30 (20170501) Heterocyclic Compounds C07D 305/10 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 15/24 (20130101) Original (OR) Class C07H 15/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230096203 | Garcia Hernandez et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vicky Garcia Hernandez (Ann Arbor, Michigan); Amnah Yamani (Ann Arbor, Michigan); Asma Nusrat (Ann Arbor, Michigan); Simon Patrick Hogan (Ann Arbor, Michigan) |
| ABSTRACT | Provided herein are methods for determining the presence of desmoglein-2 protein fragments in a sample obtained from a subject suspected of having a food allergy, as well as methods of treating a food allergy. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/795895 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/137 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/08 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) G01N 2333/705 (20130101) G01N 2800/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230096494 | LI et al. |
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| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Lingjun LI (Madison, Wisconsin); Yu FENG (Madison, Wisconsin); Bingming CHEN (Norristown, Pennsylvania); Qinying YU (Madison, Wisconsin); Xuefei ZHONG (Seattle, Washington); Miyang LI (Madison, Wisconsin) |
| ABSTRACT | The present invention provides a set of novel isobaric chemical tags, also referred herein as SUGAR (Isobaric Multiplex Reagents for Carbonyl Containing Compound). These labeling tags are compact and easy to synthesize at high yield and purity in just a few steps using commercially available starting materials. The tagging reagents of the present invention comprise: a) a reporter group, having at least one atom that is optionally isotopically labeled; b) a balancing group, also having at least one atom that is optionally isotopically labeled, and c) an aldehyde, ketone, or carboxylic acid reactive group. The multiplex SUGAR tags are able to react with an aldehyde, ketone, or carboxylic acid group of the molecule to be tagged, which offers the capability for labeling and quantitation of glycans, proteins/peptides, and fatty acids. |
| FILED | Wednesday, November 23, 2022 |
| APPL NO | 17/993725 |
| CURRENT CPC | General Methods of Organic Chemistry; Apparatus Therefor C07B 59/001 (20130101) Original (OR) Class C07B 2200/05 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6848 (20130101) G01N 2440/38 (20130101) G01N 2458/15 (20130101) G01N 2570/00 (20130101) G01N 2800/52 (20130101) Technical Subjects Covered by Former US Classification Y10T 436/143333 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230096500 | Szostak et al. |
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| FUNDED BY |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michal Szostak (Newark, New Jersey); Qun Zhao (Newark, New Jersey); Guangrong Meng (Newark, New Jersey); Guangchen Li (Newark, New Jersey) |
| ABSTRACT | Provided herein, in part, is a new class of sterically bulky, easily prepared N-heterocyclic carbene (NHC) ligands of Formula I, or a salt, solvate, geometric isomer, or stereoisomer thereof. The ligands are readily synthetically accessible exploiting the cost-effective, modular alkylation of anilines. The NHC ligands of the present disclosure can be used to prepare effective catalysts with transition metals, including the compound of Formula II, or a salt, solvate, geometric isomer, or stereoisomer thereof. In certain embodiments, the transition metal is Pd. |
| FILED | Friday, January 08, 2021 |
| APPL NO | 17/791673 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/181 (20130101) B01J 31/2273 (20130101) Original (OR) Class B01J 31/2278 (20130101) B01J 31/2295 (20130101) B01J 31/2404 (20130101) B01J 2231/42 (20130101) B01J 2531/18 (20130101) B01J 2531/822 (20130101) B01J 2531/824 (20130101) Heterocyclic Compounds C07D 233/62 (20130101) C07D 235/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230096554 | Jaenisch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Whitehead Institute for Biomedical Research (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rudolf Jaenisch (Brookline, Massachusetts); X. Shawn Liu (Cambridge, Massachusetts); Hao Wu (Newton, Massachusetts) |
| ABSTRACT | The invention relates to methods of modifying DNA methylation by contacting a cell with a catalytically inactive site specific nuclease fused to an effector domain having methylation or demethylation activity and one or more guide sequences. |
| FILED | Wednesday, July 06, 2022 |
| APPL NO | 17/858758 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/30 (20130101) A61K 35/33 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 9/1007 (20130101) C12N 15/11 (20130101) C12N 15/86 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) C12N 2740/15031 (20130101) C12N 2800/80 (20130101) Enzymes C12Y 201/01037 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230096704 | Sayour et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elias Sayour (Newberry, Florida); Hector Ruben Mendez-Gomez (Gainesville, Florida); Sadeem Qdaisat (Gainesville, Florida); Loic Pierre Deleyrolle (Gainesville, Florida); Duane A. Mitchell (Gainesville, Florida) |
| ABSTRACT | Provided herein are compositions comprising a liposome comprising ribonucleic acid (RNA) molecules and a cationic lipid, wherein the RNA molecules bind to or encode an epitope of a nucleic acid encoding a fusion protein expressed by a tumor. The disclosure also provides a nanoparticle comprising a positively-charged surface and an interior comprising (i) a core and (ii) at least two nucleic acid layers, wherein each nucleic acid layer is positioned between a cationic lipid bilayer, and nucleic acid molecules in the nucleic acid layers comprise a sequence of a nucleic acid molecule expressed by slow-cycling cells (SCCs). Also provided herein re methods of making a nanoparticle and methods of increasing an immune response against a tumor in a subject. Methods of treating a subject with a disease are provided herein. |
| FILED | Friday, February 05, 2021 |
| APPL NO | 17/797810 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1272 (20130101) A61K 9/1278 (20130101) A61K 39/001196 (20180801) Original (OR) Class A61K 2039/5154 (20130101) A61K 2039/6018 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/4748 (20130101) C07K 2319/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230096719 | Chennubhotla et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh-Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh-Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Srinivas C. Chennubhotla (Pittsburgh, Pennsylvania); Om Choudhary (Pittsburgh, Pennsylvania); Akif Burak Tosun (Pittsburgh, Pennsylvania); Jeffrey Fine (Pittsburgh, Pennsylvania) |
| ABSTRACT | A method (and system) of segmenting one or more histological structures in a tissue image represented by multi-parameter cellular and sub-cellular imaging data includes receiving coarsest level image data for the tissue image, wherein the coarsest level image data corresponds to a coarsest level of a multiscale representation of first data corresponding to the multi-parameter cellular and sub-cellular imaging data. The method further includes breaking the coarsest level image data into a plurality of non-overlapping superpixels, assigning each superpixel a probability of belonging to the one or more histological structures using a number of pre-trained machine learning algorithms to create a probability map, extracting an estimate of a boundary for the: one or more histological structures by applying a contour algorithm to the probability map, and using the estimate of the boundary to generate a refined boundary for the one or more histological structures. |
| FILED | Tuesday, March 16, 2021 |
| APPL NO | 17/909891 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 7/12 (20170101) G06T 7/143 (20170101) G06T 7/149 (20170101) G06T 2207/20016 (20130101) G06T 2207/20116 (20130101) G06T 2207/30024 (20130101) Image or Video Recognition or Understanding G06V 10/70 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230096779 | COON et al. |
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| FUNDED BY |
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| APPLICANT(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin) |
| ASSIGNEE(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (MADISON, Wisconsin) |
| INVENTOR(S) | JOSHUA COON (MIDDLETON, Wisconsin); MICHAEL WESTPHALL (FITCHBURG, Wisconsin); IAN MILLER (MADISON, Wisconsin); LLOYD SMITH (MADISON, Wisconsin); KEATON MERTZ (LA JOLLA, California) |
| ABSTRACT | Systems for monitoring metabolites may include a sample collection system and a urinalysis system of or for a toilet. The sample collection system may be automated to collect sample urine from a toilet or toilet area, transport the sample to the urinalysis system, and/or the sample urine for analysis at a later time or after analysis by the urinalysis system. The urinalysis system may be automated by proactively providing test material on which a subject may provide a urine sample. Once the urine sample has been provided the urinalysis system may provide the test material to an analyzer for analysis. Results of the analysis of the test material and sample urine may be provided to a mobile device of the subject and/or a remote server. The urinalysis system may provide a urine sample to a mass spectrometry unit for analysis. |
| FILED | Friday, December 02, 2022 |
| APPL NO | 18/074060 |
| CURRENT CPC | Water-closets or Urinals With Flushing Devices; Flushing Valves Therefor E03D 11/11 (20130101) E03D 13/005 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/20 (20130101) G01N 30/7233 (20130101) G01N 33/493 (20130101) Original (OR) Class G01N 2030/201 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230096781 | Sasaki |
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| FUNDED BY |
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| APPLICANT(S) | University of Cincinnati (Cincinnati, Ohio) |
| ASSIGNEE(S) | University of Cincinnati (Cincinnati, Ohio) |
| INVENTOR(S) | Atsuo Sasaki (Cincinnati, Ohio) |
| ABSTRACT | A method for treating a metabolic disorder associated with abnormal bodyweight in a subject is provided, the method including administering to the subject an effective amount of a compound that modulates phosphatidylinositol 5-phosphate 4-kinase beta (PI5P4Kβ) activity, wherein a PI5P4Kβ inhibitor is administered when the subject suffers from a metabolic disorder associated with an underweight bodyweight; and wherein a PI5P4Kβ agonist is administered when the subject suffers from a metabolic disorder associated with an overweight or obese bodyweight. Also provided herein are methods of increasing meat quality and/or yield in livestock or domesticated poultry by administering to an animal an effective amount of a PI5P4Kβ inhibitor, and genetically engineered animals having a substitution in PI5P4Kβ that reduces its GTP-sensing activity. |
| FILED | Tuesday, March 02, 2021 |
| APPL NO | 17/909187 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0278 (20130101) Original (OR) Class A01K 2217/072 (20130101) A01K 2227/105 (20130101) A01K 2267/0306 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/365 (20130101) A61K 31/7105 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/04 (20180101) A61P 21/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1205 (20130101) Enzymes C12Y 101/01205 (20130101) C12Y 207/01149 (20130101) C12Y 603/05002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230096831 | JAVITT et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York); Research Foundation for Mental Hygiene, Inc. (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel JAVITT (Fort Lee, New Jersey); Marta MORENO (Hopewell Juntion, New York) |
| ABSTRACT | Exemplary system, method, and computer-accessible medium for determining a position or a characteristic of a target(s) for a transcranial magnetic stimulation (TMS) treatment of a patient(s) can be provided. For example, it is possible to, for example, receive imaging information of a portion(s) of a head of the patient(s), and determine the position or the characteristic of the target(s) for the TMS treatment of the patient(s) based on the imaging information. The imaging information can be magnetic resonance imaging information. The imaging information can include information regarding a brain and a skull of the patient(s). The position or the characteristic of the target(s) can be determined by identifying (i) the skull, and (ii) a parcel in a section(s) of a brain of the patient(s). The parcel can a dorsolateral prefrontal cortex (DLPFC) parcel. The DLPFC parcel can be identified using a parcellation procedure, which can be a human connectome pipeline procedure. |
| FILED | Monday, November 28, 2022 |
| APPL NO | 17/994826 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4848 (20130101) Original (OR) Class Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 2/006 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 7/70 (20170101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 70/60 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230096920 | Prisinzano et al. |
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| FUNDED BY |
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| APPLICANT(S) | Victoria Link Ltd. (Kelburn, New Zealand); University of Kansas (Lawrence, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas Edward Prisinzano (Lawrence, Kansas); Bronwyn Maree Kivell (Wellington, New Zealand); Anne Camille La Flamme (Wellington, New Zealand) |
| ABSTRACT | The present invention relates generally to methods of using nalfurafine for treating and/or preventing demyelinating disease in a subject, and in particular for treating and/or preventing multiple sclerosis (MS). Also disclosed is nalfurafine for use in treating and/or preventing MS as well as pharmaceutical compositions and unit dosage forms comprising nalfurafine for use for treating and/or preventing demyelinating disease in a subject, and in particular for treating and/or preventing MS. |
| FILED | Friday, September 30, 2022 |
| APPL NO | 17/957350 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/485 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230097057 | Boger |
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| FUNDED BY |
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| APPLICANT(S) | Ravit Boger (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ravit Boger (Baltimore, Maryland) |
| ABSTRACT | The disclosure herein provides compounds of formulas I-V which are useful in the inhibition of viral diseases in a subject. In some embodiments, the compounds of formulas I-V are useful in the inhibition of herpes viruses. |
| FILED | Friday, January 22, 2021 |
| APPL NO | 17/794820 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/341 (20130101) A61K 31/407 (20130101) A61K 31/454 (20130101) A61K 31/475 (20130101) A61K 31/496 (20130101) A61K 31/517 (20130101) A61K 31/522 (20130101) A61K 31/4985 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/22 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230097618 | Xu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Yan Xu (Pittsburgh, Pennsylvania); Pei Tang (Pittsburgh, Pennsylvania); Marta Megan Wells (Pittsburgh, Pennsylvania) |
| ABSTRACT | Compounds and methods for modulating the activity of receptors are disclosed. Some of the compounds modulate the activity of glycine receptors. Certain embodiments of the compounds are useful for treatment of pain, treatment of opioid addiction, and/or reduction of side effects attributable to opioid use. |
| FILED | Thursday, September 08, 2022 |
| APPL NO | 17/940803 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/166 (20130101) A61K 31/452 (20130101) Original (OR) Class A61K 31/485 (20130101) A61K 31/495 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/04 (20180101) A61P 25/36 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230097658 | Olson et al. |
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| FUNDED BY |
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| APPLICANT(S) | FRED HUTCHINSON CANCER RESEARCH CENTER (Seattle, Washington); UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| ASSIGNEE(S) | FRED HUTCHINSON CANCER RESEARCH CENTER (Seattle, Washington); UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| INVENTOR(S) | James Olson (Seattle, Washington); Eric Nealy (Seattle, Washington); Cole DeForest (Seattle, Washington); Andrew Mhyre (Seattle, Washington) |
| ABSTRACT | The present disclosure describes an immunotherapy delivery hydrogel system. The immunotherapy delivery hydrogel system can be degradable and can release therapeutic agents at a tunable rate, and in a controlled manner. The immunotherapy delivery hydrogel system includes a hydrogel matrix and cancer therapeutic agent(s) associated with the hydrogel matrix. The hydrogel system can further include tumor cell-attractant(s) conjugated to the hydrogel matrix. The tumor cell-attractant(s) and the cancer therapeutic agent(s) act synergistically to treat cancer. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/905011 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0024 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2803 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230097743 | Xu |
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| FUNDED BY |
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| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qiaobing Xu (Lexington, Massachusetts) |
| ABSTRACT | Disclosed are lipid compounds comprising imidazole heads and lipidoid nanoparticles (LNPs) comprising the lipidoid compounds disclosed herein for efficient nucleic acid delivery to T cells. |
| FILED | Tuesday, March 02, 2021 |
| APPL NO | 17/909260 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1272 (20130101) A61K 31/69 (20130101) A61K 31/282 (20130101) A61K 31/337 (20130101) A61K 31/454 (20130101) A61K 31/506 (20130101) A61K 31/513 (20130101) A61K 31/519 (20130101) A61K 31/704 (20130101) A61K 31/7048 (20130101) A61K 31/7056 (20130101) A61K 31/7068 (20130101) A61K 38/14 (20130101) A61K 47/52 (20170801) Heterocyclic Compounds C07D 233/61 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/88 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230097883 | PHAM et al. |
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| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wellington PHAM (Nashville, Tennessee); William J. Behof (Nashville, Tennessee); Clayton Whitmore (Nashville, Tennessee); Dmitry Koktysh (Nashville, Tennessee); Justin Haynes (Nashville, Tennessee) |
| ABSTRACT | The present disclosure includes precursor compounds and probes such as ergothioneine (ERGO) based positron emission tomography (PET) (ERGO PET) probes or compounds or compositions including the ERGO PET probe such as pharmaceutical compositions, methods of making the ERGO PET probes or compositions, methods of imaging using the ERGO PET probes or compositions, and the like. The present disclosure provides for ERGO PET probes or compositions that can be used for imaging, diagnosing, localizing, monitoring, and/or assessing neurodegenerative diseases and inflammatory diseases or related biological conditions. |
| FILED | Wednesday, August 31, 2022 |
| APPL NO | 17/823707 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/0453 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230097887 | Spiegel et al. |
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| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Spiegel (New Haven, Connecticut); David Caianiello (Brooklyn, New York) |
| ABSTRACT | Described herein is a bi-functional compound for removing macrophage migration inhibitory factor (MIF) or immunoglobin G (IgG). Further described herein is a pharmaceutical composition which comprise these bi-functional compounds. Further described herein is a method for treating disease states and/or conditions with the compounds or the composition. The disease states and/or conditions are mediated through MIF/IgG or where MIF/IgG is a contributing factor to the development and perpetuation of diseases and/or conditions, such as autoimmune diseases and cancer, among others. |
| FILED | Tuesday, March 15, 2022 |
| APPL NO | 17/695259 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) A61K 47/55 (20170801) Original (OR) Class A61K 47/545 (20170801) A61K 47/549 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230098149 | Chilkoti et al. |
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| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ashutosh Chilkoti (Durham, North Carolina); Jacob Heggestad (Durham, North Carolina); David Kinnamon (Durham, North Carolina); Angus Hucknall (Durham, North Carolina) |
| ABSTRACT | Disclosed herein are devices that can be used to detect neutralizing antibodies against multiple pathogens in a quick and accurate manner. An example device includes a substrate; a non-fouling layer; a plurality of pathogen regions, each pathogen region including a different pathogen; and at least one detection region, the detection region including a detection agent that is capable of specifically binding each pathogen and an excipient. In addition, an example method includes contacting a biological sample with a device, and detecting the presence of a neutralizing antibody in the biological sample for each pathogen, wherein the presence of the neutralizing antibody is detected by inhibiting the binding of the detection agent to each pathogen. |
| FILED | Friday, September 30, 2022 |
| APPL NO | 17/957373 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 33/56983 (20130101) Original (OR) Class G01N 2021/6439 (20130101) G01N 2333/165 (20130101) G01N 2469/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230098438 | Gibbs et al. |
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| FUNDED BY |
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| APPLICANT(S) | Oregon Health and Science University (Portland, Oregon) |
| ASSIGNEE(S) | Oregon Health and Science University (Portland, Oregon) |
| INVENTOR(S) | Summer L. Gibbs (West Linn, Oregon); Lei G. Wang (Portland, Oregon); Connor W. Barth (Portland, Oregon) |
| ABSTRACT | This invention provides novel oxazine-based, water soluble fluorophore compounds useful in in vivo nerve imaging, as well as compositions comprising them and methods for their use. |
| FILED | Monday, December 21, 2020 |
| APPL NO | 17/790698 |
| CURRENT CPC | Heterocyclic Compounds C07D 265/38 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
20230098624 — METHODS AND VACCINES FOR INDUCING IMMUNE RESPONSES TO MULTIPLE DIFFERENT MHC MOLECULES
| US 20230098624 | McCurry et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota); University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dustin B. McCurry (Phoenix, Arizona); Peter A. Cohen (Scottsdale, Arizona); Latha B. Pathangey (Scottsdale, Arizona); Sandra J. Gendler (Scottsdale, Arizona); Mary L. Disis (Renton, Washington) |
| ABSTRACT | This document provides methods and materials relating to isolated polypeptides, polypeptide preparations, vaccine preparations (e.g., anti-cancer vaccine preparations), and methods for vaccinating mammals. For example, polypeptides (e.g., CMV, MUC1, HER2, Mesothelin (MESO), TRAG-3, or CALR polypeptides) having the ability to be processed into different polypeptides such that the processed polypeptides as a group are capable of being presented by different MHC molecules present in a particular mammalian population are provided. |
| FILED | Wednesday, August 24, 2022 |
| APPL NO | 17/822051 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) A61K 39/12 (20130101) A61K 39/39 (20130101) A61K 39/00117 (20180801) A61K 39/245 (20130101) A61K 39/001106 (20180801) A61K 39/001114 (20180801) Original (OR) Class A61K 39/001168 (20180801) A61K 39/001184 (20180801) A61K 2039/55505 (20130101) A61K 2039/55511 (20130101) A61K 2039/55561 (20130101) A61K 2039/55566 (20130101) A61K 2039/55572 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Peptides C07K 14/005 (20130101) C07K 16/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2710/16122 (20130101) C12N 2710/16134 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230098646 | Langer et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Robert S. Langer (Newton, Massachusetts); Polina Anikeeva (Lexington, Massachusetts); Carlo Giovanni Traverso (Newton, Massachusetts); Shriya Srinivasan (Cambridge, Massachusetts); Marc-Joseph Antonini (Boston, Massachusetts) |
| ABSTRACT | Articles and systems configured for treating GI motility disorders are generally provided. In some embodiments, an article comprising one or more electrodes (with both sensing and stimulating capabilities) may be configured to stimulate one or more tissues in the GI tract, electrically and/or chemically, to modulate peristalsis and/or allow neuromodulation. In some embodiments, a system comprises a controller that allows for close-loop operation of the article, e.g., such that the article may stimulate (e.g., via a feedback loop) the one or more organs in the GI tract upon receiving sensed parameters in the GI tract. In some embodiments, an implantation tool comprising a sensor may allow for submucosal or intramuscular implantation of an article. The implantation tool and the article may be useful for, for example, as a general platform for delivery of treating GI motility disorders and/or neuromodulation of the GI tract. |
| FILED | Thursday, September 29, 2022 |
| APPL NO | 17/956032 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0538 (20130101) A61B 5/6851 (20130101) A61B 17/3421 (20130101) A61B 17/3468 (20130101) A61B 2017/00867 (20130101) A61B 2017/3454 (20130101) A61B 2560/063 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 31/10 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0509 (20130101) A61N 1/36007 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230098649 | Dikalov et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sergey I Dikalov (Nashville, Tennessee); Venkataraman Amarnath (Nashville, Tennessee) |
| ABSTRACT | The use of novel 2-hydroxybenzylamine derivatives as scavengers of isolevuglandins. |
| FILED | Wednesday, January 27, 2021 |
| APPL NO | 17/795861 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/137 (20130101) A61K 31/4425 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230098667 | Mekonnen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AGENEBIO, INC. (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Belew Mekonnen (Gilbertsville, Pennsylvania); John A. Butera (Clarksburg, New Jersey); Jianxing Huang (Bethlehem, Pennsylvania); Hemantbhai Patel (Piscataway, New Jersey); Qin Jiang (Latham, New York); Robert Jason Herr (Voorheesville, New York); Emily Elizabeth Freeman (Voorheesville, New York); Nicholas James Mayhew (Niskayuna, New York) |
| ABSTRACT | This invention relates to benzodiazepine derivatives, compositions comprising therapeutically effective amounts of those derivatives and methods of using those derivatives or compositions in treating cognitive impairment associated with CNS disorders. It also relates to the use of an α5-containing GABAA receptor agonist (e.g, an α5-containing GABAA receptor positive allosteric modulator) in treating cognitive impairment associated with CNS disorders in a subject in need or at risk thereof, including age-related cognitive impairment, Mild Cognitive Impairment (MCI), amnestic MCI, Age-Associated Memory Impairment, Age Related Cognitive Decline, dementia, Alzheimer's Disease (AD), prodromal AD, PTSD, schizophrenia, bipolar disorder, ALS, cancer-therapy-related cognitive impairment, mental retardation, Parkinson's disease, autism spectrum disorders, fragile X disorder, Rett syndrome, compulsive behavior, and substance addiction. It also relates to the use of an α5-containing GABAA receptor agonist (e.g., an α5-containing GABAA receptor positive allosteric modulator) in treating brain cancers (including brain tumors, e.g., medulloblastomas), and cognitive impairment associated therewith. |
| FILED | Friday, December 18, 2020 |
| APPL NO | 17/786175 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/13 (20130101) A61K 31/27 (20130101) A61K 31/55 (20130101) A61K 31/445 (20130101) A61K 31/496 (20130101) A61K 31/5513 (20130101) A61K 31/5517 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Heterocyclic Compounds C07D 487/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230098674 | Alsberg et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio); Worcester Polytechnic Institute (Worcester, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eben Alsberg (Cleveland, Ohio); Anna D. Dikina (Mentor, Ohio); Marsha W. Rolle (Worcester, Massachusetts); Hannah A. Strobel (Marlborough, Massachusetts) |
| ABSTRACT | A modular engineered tissue construct includes a plurality of fused self-assembled, scaffold-free, high-density cell aggregates. At least one cell aggregate includes a plurality of cells and a plurality of biocompatible and biodegradable nanoparticles and/or microparticles that are incorporated within the cell aggregates. The nanoparticles and/or microparticles acting as a bulking agent within the cell aggregate to increase the cell aggregate size and/or thickness and improve the mechanical properties of the cell aggregate as well as to deliver bioactive agents. |
| FILED | Tuesday, March 15, 2022 |
| APPL NO | 17/695215 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) A61K 35/32 (20130101) A61K 35/42 (20130101) A61K 35/44 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/54 (20130101) A61L 27/58 (20130101) A61L 27/3804 (20130101) A61L 27/3817 (20130101) Original (OR) Class A61L 27/3839 (20130101) A61L 27/3886 (20130101) Apparatus for Enzymology or Microbiology; C12M 25/14 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0655 (20130101) C12N 5/0697 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230098681 | Nash et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California); The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Landon D. Nash (Sunnyvale, California); Duncan J. Maitland (College Station, Texas); Nicole Docherty (Troy, Michigan); Thomas S. Wilson (San Leandro, California); Ward Small, IV (Livermore, California); Jason Ortega (Pacifica, California); Pooja Singhal (Redwood City, California) |
| ABSTRACT | An embodiment includes a system comprising: a monolithic shape memory polymer (SMP) foam having first and second states; wherein the SMP foam includes: (a) polyurethane, (b) an inner half portion having inner reticulated cells defined by inner struts, (c) an outer half portion, having outer reticulated cells defined by outer struts, surrounding the inner portion in a plane that provides a cross-section of the SMP foam, (d) hydroxyl groups chemically bound to outer surfaces of both the inner and outer struts. Other embodiments are discussed herein. |
| FILED | Thursday, September 29, 2022 |
| APPL NO | 17/956236 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 24/0036 (20130101) A61L 24/046 (20130101) A61L 31/06 (20130101) A61L 31/14 (20130101) A61L 31/146 (20130101) Processes for Applying Fluent Materials to Surfaces, in General B05D 1/62 (20130101) B05D 3/144 (20130101) B05D 7/02 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 59/14 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2033/04 (20130101) B29K 2995/0093 (20130101) Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 5/18 (20130101) B32B 27/06 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 9/36 (20130101) C08J 9/365 (20130101) Original (OR) Class C08J 2201/026 (20130101) C08J 2375/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230098686 | Gibbs et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | OREGON HEALTH and SCIENCE UNIVERSITY (Portland, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Summer L Gibbs (Portland, Oregon); Lei Wang (Portland, Oregon); Connor W. Barth (Portland, Oregon) |
| ABSTRACT | Nerve-specific fluorophore formulations of Formula (I) for direct or systemic administration are described. The formulations can be used in fluorescence-guided surgery (FGS) to aid in nerve preservation during surgical interventions. |
| FILED | Friday, April 09, 2021 |
| APPL NO | 17/797819 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/0028 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230098714 | SUN |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | New York R and D Center for Translational Medicine and Therapeutics, Inc. (New Rochelle, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hui B. SUN (New Rochelle, New York) |
| ABSTRACT | Provided herein are compositions and methods of use for mimicking miRNA activity. For example, these compositions can be effective in modulating expression of pro-inflammatory mediators, such as NLRP3. The compositions can be useful for treating musculoskeletal or connective tissue repair or degenerative conditions, for example, tendinopathy and tendon injury. |
| FILED | Friday, August 05, 2022 |
| APPL NO | 17/882009 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/141 (20130101) C12N 2310/315 (20130101) C12N 2310/321 (20130101) C12N 2310/323 (20130101) C12N 2310/3515 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230098847 | Stoltz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian M. Stoltz (San Marino, California); Scott C. Virgil (Pasadena, California); David E. White (Wayne, Pennsylvania); Taiga Yurino (Kyoto, Japan); Yiyang Liu (Pasadena, California); Douglas C. Behenna (Laguna Niguel, California); Douglas Duquette (Los Angeles, California); Christian Eidamshaus (Pasadena, California) |
| ABSTRACT | The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II): comprising treating a compound of Formula (I): with a transition metal catalyst and under alkylation conditions as valence and stability permit. |
| FILED | Monday, July 18, 2022 |
| APPL NO | 17/867233 |
| CURRENT CPC | Heterocyclic Compounds C07D 207/06 (20130101) C07D 207/08 (20130101) C07D 207/10 (20130101) C07D 207/16 (20130101) C07D 207/26 (20130101) C07D 207/27 (20130101) C07D 207/46 (20130101) C07D 207/263 (20130101) C07D 207/267 (20130101) C07D 207/273 (20130101) C07D 207/277 (20130101) C07D 211/16 (20130101) C07D 211/18 (20130101) C07D 211/22 (20130101) C07D 211/34 (20130101) C07D 211/38 (20130101) C07D 211/60 (20130101) C07D 211/76 (20130101) C07D 211/78 (20130101) Original (OR) Class C07D 211/88 (20130101) C07D 211/90 (20130101) C07D 211/94 (20130101) C07D 211/96 (20130101) C07D 223/04 (20130101) C07D 223/10 (20130101) C07D 241/04 (20130101) C07D 241/08 (20130101) C07D 241/52 (20130101) C07D 265/30 (20130101) C07D 265/32 (20130101) C07D 309/04 (20130101) C07D 309/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230098944 | CATALANO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cognition Therapeutics, Inc. (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | Cognition Therapeutics, Inc. (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Susan CATALANO (Pittsburgh, Pennsylvania); Nicholas IZZO (Pittsburgh, Pennsylvania) |
| ABSTRACT | The present disclosure relates to methods of decreasing amyloid β monomers and methods of treating cognitive decline in a subject, wherein the treatment results in an increase in amyloid β oligomers and a reduction in cognitive decline. The present disclosure relates to treating cognitive decline, wherein target engagement can be measured in the clinic after treating. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/798667 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4035 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230098968 | Allbritton et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nancy L. Allbritton (Seattle, None); Yuli Wang (Lynnwood, None); Raehyun Kim (Chapel Hill, None) |
| ABSTRACT | A method for producing tissue constructs comprising two or more distinct regions, each of which comprises a different cell population or lineage is described. The method involves providing a support substrate or substrate assembly comprising two or more physically distinct regions, wherein the two or more physically distinct regions of the support substrate or substrate assembly are different from each other; and depositing/positioning one or more cells on the support substrate or substrate assembly. The cells can form a continuous monolayer with at least two zones, e.g., a proliferative zone and a nonproliferative zone, that can act as in vitro intestinal models. The models are two-dimensional, thus facilitating rapid and facile imaging Systems comprising the tissue constructs and methods of using the constructs to study the effects of pharmaceuticals, uutraceuticais, and metabolites on intestinal cells are also described. |
| FILED | Friday, May 24, 2019 |
| APPL NO | 17/044157 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) Original (OR) Class C12M 25/04 (20130101) C12M 35/08 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230098978 | KORMAN |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | INVIZYNE TECHNOLOGIES, INC. (Monrovia, California) |
| ASSIGNEE(S) | INVIZYNE TECHNOLOGIES, INC. (Monrovia, California) |
| INVENTOR(S) | Tyler P. KORMAN (Sierra Madre, California) |
| ABSTRACT | The present disclosure relates to recombinant prenyltransferase enzymes with increased thermostability and activity and the use of these enzymes in compositions and methods for biosynthesis involving prenylation reactions, including compositions and methods for the preparation of cannabinoids. |
| FILED | Thursday, September 22, 2022 |
| APPL NO | 17/934560 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1085 (20130101) Original (OR) Class C12N 15/52 (20130101) C12N 15/8243 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/42 (20130101) Enzymes C12Y 203/01206 (20150701) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230099018 | Schiffer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Celia A. Schiffer (Shrewsbury, Massachusetts); Akbar Ali (Westborough, Massachusetts); Ashley N. Matthew (Worcester, Massachusetts) |
| ABSTRACT | The invention provides novel classes of HCV therapeutics that are orally available, safe and effective HCV NS3/4A protease inhibitors and are less susceptible to drug resistance than existing therapeutics. The invention also relates to pharmaceutical composition of these compounds and methods of preparation and use thereof. |
| FILED | Friday, August 19, 2022 |
| APPL NO | 17/891869 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/498 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Heterocyclic Compounds C07D 241/20 (20130101) Original (OR) Class Peptides C07K 5/101 (20130101) C07K 5/0808 (20130101) C07K 5/1016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230099106 | Scheinberg et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Memorial Sloan Kettering Cancer Center (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David A. Scheinberg (New York, New York); Thomas J. Gardner (New York, New York); Derek Tan (New York, New York); Jonghan P. Lee (New York, New York) |
| ABSTRACT | Provided herein are prodrug compounds of Formula (I) and compositions thereof useful in methods for adoptive cell therapy. |
| FILED | Thursday, January 28, 2021 |
| APPL NO | 17/795751 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/517 (20130101) Original (OR) Class A61K 35/17 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230099379 | Liggett et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of South Florida (Tampa, Florida); The Florida International University Board of Trustees (Miami, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen Bryant Liggett (Treasure Island, Florida); Donghwa Kim (Tampa, Florida); Marcello Giulianotti (Vero Beach, Florida) |
| ABSTRACT | Disclosed herein are compounds, compositions, and methods for selecting targeting β2AR receptors. The compounds, compositions, and methods may be used in the treatment of obstructive lung diseases. |
| FILED | Friday, September 02, 2022 |
| APPL NO | 17/902085 |
| CURRENT CPC | Heterocyclic Compounds C07D 403/06 (20130101) Original (OR) Class C07D 417/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230099637 | Arbiser et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Emory University (Atlanta, Georgia); The United States Govermment represented by The Unitd States Department of Venterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jack Arbiser (Atlanta, Georgia); Lily Yang (Atlanta, Georgia) |
| ABSTRACT | This disclosure relates to palladium hyaluronic acid particles such as dibenzylideneacetone palladium hyaluronic acid particles. In certain embodiments, this disclosure relates to methods of managing cancer or angiogenic conditions using particles disclosed herein and pharmaceutical compositions comprising the same. In certain embodiments, an objective of this disclosure is hyaluronic acid targeting of CD44, a tumor stem cell marker. In certain embodiments, this disclosure relates to treatment with hyaluronic acid palladium particles disclosed herein for depleting CD44 cells. |
| FILED | Thursday, May 16, 2019 |
| APPL NO | 17/055945 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/20 (20130101) A61K 9/0056 (20130101) A61K 31/56 (20130101) A61K 31/728 (20130101) A61K 33/24 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230099696 | ZHOU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qi ZHOU (West Lafayette, Indiana); Chune ZHU (Guangzhou, Guangdong, China PRC) |
| ABSTRACT | The present disclosure generally relates to a process for manufacturing a microparticle composite or a dry powder inhaler composition of polymyxin and CFTR activator or CFTR potentiator comprising the steps preparing a suspension of nanoparticles (NPs) of CFTR activator or CFTR potentiator or their combinations; mixing the suspension of NPs with a solution of polymyxin and a solution of leucine, then followed by drying to afford said micro-particle composite or dry powder inhaler composition. Pharmaceutical compositions and methods for treating a patient of cystic fibrosis (CF) and/or a lung infection are within the scope of this invention. |
| FILED | Friday, March 05, 2021 |
| APPL NO | 17/908492 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/16 (20130101) A61K 9/19 (20130101) A61K 38/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230099734 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Worcester Polytechnic Institute (Worcester, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Haichong Zhang (Shrewsbury, Massachusetts); Ryosuke Tsumura (Worcester, Massachusetts); Yichuan Tang (Millbury, Massachusetts) |
| ABSTRACT | An ultrasonic imaging configuration rendering an image based on a reflected beam aligned with a needle insertion axis provides enhanced images and guidance. A percutaneous insertion guidance device for ultrasonic (US) imaging includes an US transducer and a reflector for redirecting imaging signals between the transducer and an imaged region. An enclosure or bracket is adapted to support the reflector at a predetermined angle based on a surgical target in the imaged region such that a forward beam direction from the transducer reflects in a direction of the needle insertion as the needle passes through a discontinuity or slot in the reflector. The resulting return signal is based on an axial alignment of the US signals with the needle travel towards the surgical target. |
| FILED | Monday, November 28, 2022 |
| APPL NO | 17/994788 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/085 (20130101) A61B 8/4281 (20130101) A61B 8/4444 (20130101) A61B 17/3403 (20130101) Original (OR) Class A61B 2017/3413 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230099803 | Lamichhane et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland); University of St. Thomas (St. Paul, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gyanu Lamichhane (Towson, Maryland); J. Thomas Ippoliti (St. Paul, Minnesota) |
| ABSTRACT | The present invention is a method of treating or preventing Mycobacterium tuberculosis infection in a subject by administering to the subject an effective amount of oxazolidinone, specifically(N-(((S)-3-(dibenzo[b,e][1,4]dioxin-7-yl)-2-oxooxazolidin-5-yl)methyl)acetamide) or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof. |
| FILED | Thursday, December 01, 2022 |
| APPL NO | 18/060823 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4245 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230099804 | COSFORD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SALK INSTITUTE FOR BIOLOGICAL STUDIES (La Jolla, California); SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas D.P. COSFORD (La Jolla, California); Nicole A. BAKAS (La Jolla, California); Reuben J. SHAW (La Jolla, California); Allison S. LIMPERT (La Jolla, California); Sonja N. BRUN (La Jolla, California) |
| ABSTRACT | The present disclosure is directed to compounds, compositions, formulations and methods of use thereof in the treatment and prevention of ULK mediated diseases, including cancer. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/799634 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/282 (20130101) A61K 31/529 (20130101) Original (OR) Class A61K 45/06 (20130101) Heterocyclic Compounds C07D 498/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230099837 | Khanna et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | May Khanna (Tucson, Arizona); Jonathan Lares Sanchez (Tucson, Arizona); Vijay Gokhale (Tucson, Arizona) |
| ABSTRACT | This invention relates generally to neurodegenerative diseases and conditions (e.g., Alzheimer's disease) characterized with aberrant RIPK1/RIPK3 binding, RIPK3/MLKL binding, necrosome formation, and/or necroptosis activation. This invention further relates to methods and compositions for treating such neurodegenerative diseases and conditions with pharmaceutical compositions comprising agents capable of inhibiting RIPK1/RIPK3 binding and/or RIPK3/MLKL binding. |
| FILED | Friday, January 22, 2021 |
| APPL NO | 17/792917 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/437 (20130101) Original (OR) Class A61K 31/4402 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230100137 | Blazar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Pharmacyclics LLC (North Chicago, Illinois); Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bruce R. Blazar (Golden Valley, Minnesota); Ryan Flynn (Minneapolis, Minnesota) |
| ABSTRACT | Described herein are methods for treating and preventing alloantibody driven chronic graft versus host disease (cGVHD). The methods include administering to an individual in need thereof ibrutinib for treating and preventing alloantibody driven graft versus host disease. |
| FILED | Friday, April 29, 2022 |
| APPL NO | 17/733419 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) Original (OR) Class A61K 35/28 (20130101) A61K 45/06 (20130101) A61K 2035/124 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230100186 | Torres et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland); The Government of The United States, as represented by The Secretary of The Army (Fort Detrick, Maryland); The United States of America, as represented by the Secretary, Department of Health and Human Serv (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Oscar Torres (Silver Spring, Maryland); Gary R. Matyas (Silver Spring, Maryland); Kenner C. Rice (Rockville, Maryland); Eric W. Bow (Rockville, Maryland); Agnieszka Sulima (Rockville, Maryland); Arthur E. Jacobson (Rockville, Maryland) |
| ABSTRACT | Described is the preparation of novel fentanyl haptens of Formula (1) through (6) and their use in the preparation of effective fentanyl vaccines. |
| FILED | Wednesday, January 13, 2021 |
| APPL NO | 17/792378 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0013 (20130101) A61K 39/39 (20130101) A61K 39/385 (20130101) Original (OR) Class A61K 2039/6037 (20130101) A61K 2039/6081 (20130101) A61K 2039/55505 (20130101) A61K 2039/55555 (20130101) A61K 2039/55572 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/36 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230100371 | Zelik et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee); Herowear LLC (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karl Zelik (Nashville, Tennessee); Matthew Yandell (Nashville, Tennessee); Matthew Marino (Nashville, Tennessee); Mark Harris (Nashville, Tennessee); Rebeccah Pailes-Friedman (Nashville, Tennessee); Ryu Tomita (Nashville, Tennessee); Paul Reamey (Nashville, Tennessee); Evan Huggins (Nashville, Tennessee) |
| ABSTRACT | A wearable assistance device, such as an exosuit/exoskeleton, for providing assistance (e.g., assistive force or assistive torque) while reducing lower back muscle stress, fatigue, injury risk and/or pain is disclosed. The wearable assistance device includes adjustable modular straps and/or elastic bands. The modular straps allow swapping of different straps to achieve a custom fit of the wearable assistance device. The modular elastic bands allow swapping of different elastic bands to achieve a preferred level of assistance by the wearable assistance device. |
| FILED | Tuesday, March 16, 2021 |
| APPL NO | 17/798169 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 5/022 (20130101) Original (OR) Class A61F 5/0109 (20130101) A61F 2005/0155 (20130101) A61F 2005/0197 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230100402 | Yegnasubramanian et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Srinivasan Yegnasubramanian (Baltimore, Maryland); William G. Nelson (Baltimore, Maryland); Ajay Vaghasia (Baltimore, Maryland); Philipp Nuhn (Baltimore, Maryland) |
| ABSTRACT | The disclosure generally relates to compositions and methods for the treatment of cancer. In some aspects, disclosed herein are methods for the induction of synthetic lethality with epigenetic therapy (ISLET) using a combination of at least one epigenetic compound and at least one chemotherapeutic agent. Also disclosed herein are screening methods for identifying compounds that induce killing of cancer cells when combined with at least one epigenetic compound. Further disclosed herein are methods of potentiating a therapeutic effect of a chemotherapeutic agent against a cancer, comprising administering to a subject having the cancer an epigenetic compound in an amount effective to potentiate the therapeutic effect of the chemotherapeutic agent against the cancer. |
| FILED | Friday, September 16, 2022 |
| APPL NO | 17/946416 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/55 (20130101) A61K 31/203 (20130101) A61K 31/4188 (20130101) A61K 31/7068 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230100458 | CHAKRABARTY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (New Orleans, Louisiana); DUQUESNE UNIVERSITY OF THE HOLY GHOST (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Suravi CHAKRABARTY (Pittsburgh, Pennsylvania); Patrick T. FLAHERTY (Pittsburgh, Pennsylvania); Darlene MONLISH (Clayton, Missouri); Jane E. CAVANAUGH (Pittsburgh, Pennsylvania); Matthew E. BUROW (Slidell, Louisiana); Steven ELLIOTT (New Orleans, Louisiana); Van T. HOANG (New Orleans, Louisiana) |
| ABSTRACT | Disclosed are anthranilic amide derivatives having the formula: Compositions are disclosed that include the anthranilic amide derivatives and the use of the anthranilic amide derivatives for the manufacture of a medicament. Further disclosed are methods of inhibiting or treating cancer, inhibiting or reversing an epithelial to mesenchymal cellular transition, and/or inhibiting MEK1/2 and/or MEK 5 enzymatic activity in a subject by administering to the subject an effective amount of a disclosed anthranilic amide derivative. |
| FILED | Friday, August 26, 2022 |
| APPL NO | 17/897116 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 229/58 (20130101) C07C 237/30 (20130101) C07C 237/32 (20130101) C07C 237/34 (20130101) C07C 237/36 (20130101) Heterocyclic Compounds C07D 295/16 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230100472 | Sartor et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado); Colorado State University Research Foundation (Fort Collins, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven Sartor (Boulder, Colorado); Niels Damrauer (Boulder, Colorado); Garet Miyake (Fort Collins, Colorado); Cameron Chrisman (Fort Collins, Colorado); Ryan Pearson (Berkeley, California) |
| ABSTRACT | Phenothiazine compounds of Formula (I) are described herein. These compounds are useful as highly reducing organic photoredox catalysts. Suitable substrates for use with the compounds of Formula (I) include acrylates, styrene, acrylamides, acrylonitrile, vinyl chloride, methylacrylonitrile, vinyl acetate, and acrylic acid. |
| FILED | Friday, January 08, 2021 |
| APPL NO | 17/789874 |
| CURRENT CPC | Heterocyclic Compounds C07D 279/24 (20130101) C07D 279/30 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230100536 | Trowbridge et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aaron Trowbridge (Princeton, New Jersey); Ciaran Seath (Princeton, New Jersey); David W.C. MacMillan (Princeton, New Jersey) |
| ABSTRACT | In one aspect, transition metal complexes are described herein having composition and electronic structure for generating reactive labeling intermediates having lifetimes and diffusion radii advantageous for proximity-based labeling of various biomolecular species, including proteins, in intracellular and intercellular environments. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/802823 |
| CURRENT CPC | Heterocyclic Compounds C07D 213/22 (20130101) Original (OR) Class C07D 213/56 (20130101) C07D 213/79 (20130101) C07D 401/14 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 15/0033 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) C09K 2211/185 (20130101) C09K 2211/1007 (20130101) C09K 2211/1029 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20230100559 — Compositions and Methods for Treatment of Disease by Manipulation of Serine Metabolism
| US 20230100559 | Rabinowitz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joshua D. Rabinowitz (Princeton, New Jersey); Lifeng Yang (Princeton, New Jersey) |
| ABSTRACT | The present disclosure relates, in various embodiments, to methods of treating various NADH-mediated diseases and disorders in a subject, such as disorders characterized by excess NADH, for example, by inhibiting serine catabolism in the subject. |
| FILED | Thursday, January 07, 2021 |
| APPL NO | 17/790702 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/155 (20130101) Original (OR) Class A61K 31/352 (20130101) A61K 31/365 (20130101) A61K 31/454 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230100653 | Fuchs et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ephraim Joseph Fuchs (Baltimore, Maryland); Heather Jill Symons (Annapolis, Maryland); Lode Swinnen (Lutherville, Maryland) |
| ABSTRACT | The invention provides methods and compositions for administration of allogeneic lymphocytes as an exogenous source of CD4+ T cell help for endogenous, tumor-reactive CD8+ T cells. |
| FILED | Tuesday, February 09, 2021 |
| APPL NO | 17/797676 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/664 (20130101) A61K 35/17 (20130101) Original (OR) Class A61K 45/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0087 (20130101) C12N 5/0638 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230101009 | Fautsch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota); Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota); Regents of the University of Minnesota (Minneapolis, Minnesota) |
| INVENTOR(S) | Michael P. Fautsch (Rochester, Minnesota); Peter Dosa (Vadnais Heights, Minnesota); Michael A. Walters (Minneapolis, Minnesota); Gunda I. Georg (St. Paul, Minnesota) |
| ABSTRACT | The present invention provides benzothiadiazine and chroman derivatives and particularly diazoxide and cromakalim derivatives for use in treating glaucoma, retinopathy, treating age related macular degeneration, treating, stabilizing and/or inhibiting blood and lymph vascularization, and reducing intraocular pressure by administering a pharmaceutically effective amount of a prodrug disposed in an ophthalmically acceptable carrier to the eye, wherein the prodrug specifically modulates a KATP channel to reduce an intraocular pressure. |
| FILED | Monday, November 21, 2022 |
| APPL NO | 17/991558 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/00 (20130101) A61K 9/0048 (20130101) A61K 9/0051 (20130101) A61K 31/353 (20130101) A61K 31/454 (20130101) A61K 31/549 (20130101) A61K 31/675 (20130101) A61K 31/4025 (20130101) A61K 31/4439 (20130101) Heterocyclic Compounds C07D 201/00 (20130101) C07D 285/24 (20130101) C07D 311/20 (20130101) C07D 311/70 (20130101) C07D 405/04 (20130101) C07D 405/12 (20130101) C07D 405/14 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/6547 (20130101) C07F 9/65586 (20130101) Peptides C07K 5/06026 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230101335 | Traverso et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carlo Giovanni Traverso (Newton, Massachusetts); Yunhua Shi (Belmont, Massachusetts); Vance Soares (Boston, Massachusetts); Daniel Reker (Durham, North Carolina); Robert S. Langer (Newton, Massachusetts) |
| ABSTRACT | An ex vivo tissue composition comprising an isolated tissue explant and tissue graft is provided. Methods of making and using the tissue composition are also provided. |
| FILED | Friday, May 06, 2022 |
| APPL NO | 17/738843 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0693 (20130101) C12N 5/0697 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5011 (20130101) Original (OR) Class G01N 33/5088 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230101403 | Bugaj et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lukasz Jan Bugaj (Philadelphia, Pennsylvania); David Gonzalez-Martinez (Philadelphia, Pennsylvania) |
| ABSTRACT | Described herein is a method of treating or ameliorating cancer in a subject in need thereof. The cancer includes a cytoplasmic RTK fusion protein aggregate. The method includes administering to the subject an inhibitor for the RTK fusion protein, and an inhibitor for matrix metalloprotease. Also described herein is a composition or a kit for treating or ameliorating cancer according to the method. |
| FILED | Thursday, September 29, 2022 |
| APPL NO | 17/936654 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/005 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230101412 | Morrow et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Children's Hospital Medical Center (Cincinnati, Ohio); The General Hospital Corporation d/b/a Massachusetts General Hospital (Boston, Massachusetts); Instituto Nacional de Ciencias Medicas Y Nutricion (Ciudad de México, Mexico) |
| ASSIGNEE(S) | Children's Hospital Medical Center (Cincinnatti, Ohio); The General Hospital Corporation d/b/a Massachusetts General Hospital (Boston, Massachusetts); Instituto Nacional de Ciencias Medicas Y Nutricion (Ciudad de México, Mexico) |
| INVENTOR(S) | Ardythe L. Morrow (Cincinnatti, Ohio); David S. Newburg (Newtonville, Massachusetts); Guillermo M. Ruiz-Palacios (Mexico City, Mexico) |
| ABSTRACT | A method of inhibiting inflammation with milk oligosaccharides or glycoconjugates containing the oligosaccharides. |
| FILED | Wednesday, May 04, 2022 |
| APPL NO | 17/736468 |
| CURRENT CPC | Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 33/40 (20160801) Preparations for Medical, Dental, or Toilet Purposes A61K 31/702 (20130101) A61K 31/7016 (20130101) Original (OR) Class A61K 35/20 (20130101) A61K 47/62 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230101743 | DUNCAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (Charleston, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen DUNCAN (Hollywood, South Carolina); Juitung LIU (Sumter, South Carolina); Patrick M. WOSTER (Charleston, South Carolina); Yuri PETERSON (Charleston, South Carolina); Steven HOLSHOUSER (Charleston, South Carolina); Yu-Lin JIANG (Charleston, South Carolina) |
| ABSTRACT | The present invention relates to compounds of formula (I): including any stereochemically isomeric form thereof, or pharmaceutically acceptable salts thereof, for the treatment of, for example, hypercholesterolemia. |
| FILED | Wednesday, January 06, 2021 |
| APPL NO | 17/790798 |
| CURRENT CPC | Heterocyclic Compounds C07D 251/40 (20130101) Original (OR) Class C07D 403/04 (20130101) C07D 403/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230101768 | Mukhopadhyay et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Somshuvra Mukhopadhyay (Austin, Texas); Chunyi Liu (Austin, Texas); Donald Smith (Santa Cruz, California) |
| ABSTRACT | Disclosed is a method for treating manganese (manganese) toxicity in a subject. The method includes administering to the subject an effective amount of a hypoxia inducible factor (HIF) prolyl hydroxylase inhibitor or a pharmaceutically acceptable salt or solvate thereof. |
| FILED | Saturday, August 13, 2022 |
| APPL NO | 17/819620 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/437 (20130101) A61K 31/472 (20130101) Original (OR) Class A61K 31/513 (20130101) A61K 31/4418 (20130101) A61K 31/4704 (20130101) A61K 31/5377 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/12 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230101799 | ROACH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | San Diego State University (SDSU) Foundation, dba San Diego State University Research Foundation (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dwayne R. ROACH (San Diego, California); Tiffany LUONG (Los Angeles, California) |
| ABSTRACT | In alternative embodiments, provided are compositions, including products of manufacture and kits, and methods, for purifying bacteriophage. Provided herein is are practicable methods, or protocols, that are “Good Laboratory Manufacturing Practice” (GLMP), for phage isolation, selection, liter-scaled cultivation, and purification. In alternative embodiments, GLMP protocols as provided herein employ membrane filtration processes to yield at least about 300 treatment doses at about 109 plaque-forming units with endotoxin levels within human therapeutic regulatory limits. In alternative embodiments, provided are formulations or pharmaceutical preparations of bacteriophage comprising 109 PFU, 1010 PFU, 1011 PFU, or 1012 PFU or more per unit dose and endotoxin levels below about 5.5 EU·mL−1, or below about 5.0 EU·mL−1. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/802849 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/76 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Separation B01D 61/145 (20130101) B01D 2315/10 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/02 (20130101) C12N 2795/00051 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230101853 | Kodandaramaiah et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Suhasa B Kodandaramaiah (St Paul, Minnesota); Daryl M. Gohl (Minneapolis, Minnesota); Lyudmila Vulchanova Hart (St. Paul, Minnesota); Jacob O'Brien (Hudson, Wisconsin) |
| ABSTRACT | A system for injecting a substance into one or more cells of a cell population in a tissue sample, comprising: a robotic manipulator apparatus configured to hold and position a micropipette; an injector controller; a robotic apparatus configured to manipulate a focal plane of a microscope; and a computing device configured to, for each respective cell of the one or more cells of the tissue sample: determine a 3-dimensional location of the respective cell based on images formed by the microscope and captured by a microscope camera; control the robotic manipulator apparatus to insert the micropipette into the respective cell; and control injector controller to eject the substance out of the micropipette and into the respective cell. |
| FILED | Monday, September 26, 2022 |
| APPL NO | 17/935494 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) Original (OR) Class C12M 23/16 (20130101) C12M 23/50 (20130101) C12M 41/40 (20130101) C12M 41/48 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 35/109 (20130101) G01N 35/00693 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230102047 | BLAGG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF KANSAS (Lawrence, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian S.J. BLAGG (Lawrence, Kansas); Bhaskar Reddy KUSUMA (Lake Ronkonkoma, New York); Teather SUNDSTROM (Eckelson, North Dakota) |
| ABSTRACT | Hsp90 C-terminal inhibitors and pharmaceutical compositions containing such compounds are provided. The compounds of the disclosure are useful for the treatment and/or prevention of neurodegenerative disorders such as diabetic peripheral neuropathy. |
| FILED | Tuesday, July 12, 2022 |
| APPL NO | 17/863135 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 211/17 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 15/203 (20130101) C07H 15/207 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230102159 | Chackerian et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico); THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland); VAXINE PTY LTD. (Bedford Park, Australia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bryce C. Chackerian (Albuquerque, New Mexico); Fidel P. Zavala (Baltimore, Maryland); David S. Peabody (Albuquerque, New Mexico); Nikolai Petrovsky (Adelaide, Australia); Lucia Jelinkova (Albuquerque, New Mexico) |
| ABSTRACT | An immunogen useful for treating malaria generally includes an immunogenic carrier and an antigenic malaria circumsporozoite protein (CSP) peptide that includes the peptide NANPNVDPNANPNVD (SEQ ID NO:2) linked to the immunogenic carrier. The immunogen may be administered to a subject having or at risk of having malaria. Alternatively, the immunogen may be administered to an individual having or at risk of having Plasmodium falciparum blood stage parasitemia. In some cases, the immunogen can be administered in combination with another therapeutic agent for treating malaria of Plasmodium falciparum blood stage parasitemia. |
| FILED | Tuesday, September 27, 2022 |
| APPL NO | 17/953712 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/015 (20130101) Original (OR) Class A61K 2039/5258 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 33/06 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230102223 | LI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | HEALTH RESEARCH, INC. (Menands, New York); THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC (Bethesda, Maryland) |
| ASSIGNEE(S) | HEALTH RESEARCH, INC. (Menands, New York); THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC (Bethesda, Maryland) |
| INVENTOR(S) | Hongmin LI (Glenmont, New York); Laura D. KRAMER (Albany, New York); Zhong LI (Glenmont, New York); Ruili HUANG (Rockville, Maryland); Menghang XIA (Potomac, Maryland) |
| ABSTRACT | Provided is a method of inhibiting viral replication, including contacting one or more cells that has been infected or contacted with a flavivirus with an effective amount of niclosamide, temoporfin, nitazoxanide, tizoxanide, erythrosin B, methylene blue. Contacting one or more cells that have been infected with a flavivirus may include administering the compound to a mammal, a human, or other subject. The flavivirus may be Dengue virus serotype 1, Dengue virus serotype 2, Dengue virus serotype 3, Dengue virus serotype 4, yellow fever virus, West Nile virus, Zika virus, Japanese encephalitis virus, tick-born encephalitis virus, Powassan virus, St. Louis encephalitis virus, or other flavivirus. |
| FILED | Thursday, October 27, 2022 |
| APPL NO | 18/050177 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/167 (20130101) Original (OR) Class A61K 31/352 (20130101) A61K 31/409 (20130101) A61K 31/426 (20130101) A61K 31/609 (20130101) A61K 31/5415 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Acyclic or Carbocyclic Compounds C07C 235/64 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2770/24111 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230102414 | HOH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian Lim HOH (Gainesville, Florida); Christopher D. BATICH (Gainesville, Florida); Koji HOSAKA (Newberry, Florida) |
| ABSTRACT | The present disclosure provides for methods, devices, and compositions for controlling factors involved in the healing of lesions. The methods, devices, and composition include a first therapeutic agent which includes an amount of MCP-1 and/or osteopontin effective to promote recruitment of macrophages to the lesion site. In additional embodiments, there is further provided a second therapeutic agent which includes an inhibitor of at least one of IL-17A, CXCL1, or IL-6 to promote polarization of an amount of the macrophages to M2 phenotype macrophages at the lesion site. |
| FILED | Thursday, March 11, 2021 |
| APPL NO | 17/911026 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0024 (20130101) A61K 38/19 (20130101) A61K 38/195 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 47/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230102520 | PINKERTON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sanford Burnham Prebys Medical Discovery Institute (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anthony B. PINKERTON (Rancho Santa Fe, California); Robert J. ARDECKY (Encinitas, California); Jiwen ZOU (San Diego, California) |
| ABSTRACT | Protein tyrosine phosphatases (PTPs) are key regulators of metabolism and insulin signaling. As a negative regulator of insulin signaling, the low molecular weight protein tyrosine phosphatase (LMPTP) is a target for insulin resistance and related conditions. Described herein are compounds capable of modulating the level of activity of LMPTP, compositions, and methods of using these compounds and compositions. |
| FILED | Thursday, July 02, 2020 |
| APPL NO | 17/624052 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/08 (20130101) A61K 9/0014 (20130101) A61K 9/0053 (20130101) A61K 9/2054 (20130101) A61K 9/4825 (20130101) Heterocyclic Compounds C07D 473/34 (20130101) Original (OR) Class C07D 519/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230102580 | BORDBAR et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sinopia Biosciences, Inc. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aarash BORDBAR (San Diego, California); Warren S. WADE (San Diego, California); Hiroko MASAMUNE (San Diego, California) |
| ABSTRACT | Provided are isotopically-labelled Trapidil derivatives useful for the treatment of Parkinson's disease and movement disorders associated with Parkinson's disease. The isotopically-labelled Trapidil derivatives include deuterated Trapidil derivatives. Additionally provided are combination therapies of isotopically-labelled Trapidil derivatives and additional therapeutic agents for the treatment of Parkinson's disease and movement disorders associated with Parkinson's disease. |
| FILED | Friday, September 23, 2022 |
| APPL NO | 17/934680 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/198 (20130101) A61K 31/519 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/16 (20180101) General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/05 (20130101) Heterocyclic Compounds C07D 487/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230102879 | Kahne et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel E. Kahne (Brookline, Massachusetts); Vadim Baidin (Cambridge, Massachusetts) |
| ABSTRACT | Disclosed herein are secondary amine compounds that inhibit tRNA synthetase. The compounds of the invention are useful in inhibiting tRNA synthetase in Gram-negative bacteria and are useful in killing Gram-negative bacteria. The secondary amine compounds of the invention are also useful in the treatment of tuberculosis. |
| FILED | Tuesday, January 11, 2022 |
| APPL NO | 17/573405 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Acyclic or Carbocyclic Compounds C07C 211/27 (20130101) C07C 211/40 (20130101) C07C 215/28 (20130101) Heterocyclic Compounds C07D 209/04 (20130101) C07D 213/38 (20130101) C07D 213/643 (20130101) C07D 215/06 (20130101) C07D 215/12 (20130101) C07D 221/04 (20130101) C07D 221/20 (20130101) C07D 231/12 (20130101) C07D 231/56 (20130101) C07D 239/26 (20130101) C07D 239/34 (20130101) C07D 261/08 (20130101) C07D 267/10 (20130101) C07D 295/13 (20130101) C07D 307/14 (20130101) C07D 307/79 (20130101) C07D 307/87 (20130101) C07D 309/04 (20130101) C07D 311/74 (20130101) C07D 317/58 (20130101) C07D 319/08 (20130101) C07D 327/06 (20130101) C07D 471/04 (20130101) C07D 471/08 (20130101) C07D 493/08 (20130101) C07D 495/04 (20130101) C07D 498/08 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/027 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230103041 | MARCOTTE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| INVENTOR(S) | Edward MARCOTTE (Austin, Texas); Eric ANSLYN (Austin, Texas); Alexander BOULGAKOV (Oakland, California); Angela M. BARDO (Austin, Texas); Siyuan Stella WANG (Boston, Massachusetts); Jagannath SWAMINATHAN (Austin, Texas); Fan TU (Emeryville, California) |
| ABSTRACT | The present disclosure provides methods of identifying and quantifying the peptides displayed by the major histocompatibility complex (MHC). Such methods may comprise the ability to determine the type, identity, and quantity of each peptide displayed by the MHC. In some embodiments, these methods may be used to develop an anti-cancer therapy or type the HLA of a patient. Also provided herein are compositions comprising peptides from the MHC which have been prepared for sequencing. |
| FILED | Thursday, October 27, 2022 |
| APPL NO | 18/050363 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/582 (20130101) G01N 33/6818 (20130101) Original (OR) Class G01N 33/54306 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 50/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230103075 | Klemke et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard Klemke (La Jolla, California); Huawei Wang (La Jolla, California); Willie Pi (La Jolla, California) |
| ABSTRACT | Provided are methods for treating a disease using bioengineered enucleated cells. Also provided herein are compositions comprising enucleated cells, wherein the enucleated cells have been loaded with clinically relevant biomolecules. |
| FILED | Wednesday, August 03, 2022 |
| APPL NO | 17/880141 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/5068 (20130101) Original (OR) Class A61K 45/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0663 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230103142 | SHARMA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE PENN STATE RESEARCH FOUNDATION (University Park, Pennsylvania); UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (Louisville, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arun K. SHARMA (Hummelstown, Pennsylvania); Ashish TYAGI (College Station, Texas); Chendil DAMODARAN (College Station, Texas); Shantu AMIN (Union City, New Jersey) |
| ABSTRACT | Disclosed herein are compositions and methods relating to treating, preventing, reducing, and/or inhibiting cancers, infectious diseases, and/or neurological disorders. |
| FILED | Monday, February 15, 2021 |
| APPL NO | 17/799795 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Steroids C07J 17/00 (20130101) Original (OR) Class C07J 33/002 (20130101) C07J 43/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230103216 | Arnold et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UWM Research Foundation, Inc. (Milwaukee, Wisconsin); The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander E. Arnold (Milwaukee, Wisconsin); Douglas C. Stafford (Stoughton, Wisconsin); James M. Cook (Milwaukee, Wisconsin); Charles W. Emala (Woodcliff Lake, New Jersey); Gloria Forkuo (Milwaukee, Wisconsin); Rajwana Jahan (Milwaukee, Wisconsin); Revathi Kodali (Milwaukee, Wisconsin); Guanguan Li (Milwaukee, Wisconsin); Michael Rajesh Stephen (Milwaukee, Wisconsin) |
| ABSTRACT | Pyrrolobenzodiazepines target alpha-4 and alpha-5 GABAA receptors for use in the treatment of airway hyperresponsiveness and inflammation in asthma. Compounds selectively partition to the peripheral compartment and have reduced CNS effects. |
| FILED | Thursday, August 11, 2022 |
| APPL NO | 17/886403 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/06 (20180101) Heterocyclic Compounds C07D 487/04 (20130101) C07D 487/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230103257 | Yang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yuhong Yang (Dublin, Ohio); Chenglong Li (Gainesville, Florida); Michael Racke (Powell, Ohio) |
| ABSTRACT | In one aspect, the disclosure relates to prodrug compositions of a STAT inhibitor compound. In some aspects, the STAT is STAT3. Disclosed are pharmaceutical compositions comprising the prodrug inhibitors of STAT. In various aspects, the prodrug inhibitors of STAT can be used in methods of treating an inflammatory disorder, including multiple sclerosis, or a disorder of uncontrolled cellular proliferation, such as a cancer. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure. |
| FILED | Monday, August 22, 2022 |
| APPL NO | 17/821286 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/18 (20130101) A61K 31/428 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20230093926 | Eid et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aline Eid (Atlanta, Georgia); Jimmy Georges Donald Hester (Atlanta, Georgia); Emmanouil Tentzeris (Atlanta, Georgia) |
| ABSTRACT | An exemplary embodiment of the present disclosure provides a backscattering RFID system comprising: a combined oscillator and reflection amplifier circuit comprising a first tunnel diode having an anode and a cathode; and a biasing circuit in communication with the anode and configured to bias the first tunnel diode in a negative differential resistance region; wherein the combined oscillator and reflection amplifier circuit is configured to modulate a RF interrogation signal to produce a backscatter signal. |
| FILED | Monday, March 08, 2021 |
| APPL NO | 17/908639 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 19/0723 (20130101) Antennas, i.e Radio Aerials H01Q 1/248 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230093984 | Fischer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Felix Fischer (Oakland, California); Ryan McCurdy (Hayward, California) |
| ABSTRACT | A precision graphene nanoribbon (GNR) bridge molecule can include: a central GNR having a precision structure selected the following structural types: armchair, zigzag, cove, chevron, and fjord; a functional anchoring group at either end of the GNR selected from the following: amine, thiol, thioether, stannane, halide, boronic acid, boronic ester, azide, and carbene; a central functional conjugation group at a precisely specified location; and edge group functionalization with solubilizing groups selected from the following: linear and branched alkyl chains, substituted aromatic rings, oligoethylene glycol, carboxylic acids, and sulfonic acids. |
| FILED | Thursday, September 15, 2022 |
| APPL NO | 17/932520 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/194 (20170801) C01B 2204/065 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/4145 (20130101) G01N 27/4146 (20130101) G01N 27/4148 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230094514 | Klimkiewicz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shirley M. Klimkiewicz (Gaithersburg, Maryland); Evan P. Lloyd (Clarksville, Maryland); Brenden Herrera (Rockville, Maryland); Luke Rogers (Rockville, Maryland) |
| ABSTRACT | A continuous flow process (CFP) for the production of an acid chloride includes the following steps: (i) providing or forming a first reactant comprising a chlorine-donating compound; (ii) providing or forming a second reactant comprising a carboxylic acid; (iii) providing a first continuous flow of the first reactant into a reactor at a first flow rate; (iv) providing a second continuous flow of the second reactant into the reactor at a second flow rate; and (v) mixing the first reactant and the second reactant in a portion of the reactor and reacting the first reactant and the second reactant to provide a reaction product comprising an acid chloride. |
| FILED | Thursday, September 30, 2021 |
| APPL NO | 17/489851 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/0066 (20130101) B01J 2219/00074 (20130101) B01J 2219/00162 (20130101) Acyclic or Carbocyclic Compounds C07C 51/60 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230094587 | BLACKWELL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Helen BLACKWELL (Middleton, Wisconsin); Joseph VASQUEZ (Madison, Wisconsin); Yiftah TAL GAN (Reno, Nevada) |
| ABSTRACT | Compounds that regulate quorum sensing in Staphylococcal bacteria and in particular in Staphylococcus aureus are provided. Compounds provided are racemic, non-racemic or substantially enantiomerically pure cyclic peptides of formula I: or salts or solvates thereof, where variables R, W, X1, X2, and Z and are as described in the specification and L1 is a divalent linker which contains 1-12 carbon atoms, optionally 1-4 oxygen atoms, optionally one or two carbon-carbon double bonds, and hydrogen atoms to satisfy valency. Certain dimers of the cyclic peptides are also provided. One or more cylic peptides or dimers thereof herein can be employed to inhibit QS and to thus inhibit virulence in Staphylococcus bacteria. Compounds herein and pharmaceutical compositions containing one or more of these compounds are useful in treating infections of Staphylococcus bacteria. Methods for treating such bacterial infections are also provided. |
| FILED | Monday, August 29, 2022 |
| APPL NO | 17/823053 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Heterocyclic Compounds C07D 273/00 (20130101) C07D 285/00 (20130101) C07D 291/02 (20130101) Original (OR) Class C07D 413/12 (20130101) C07D 417/12 (20130101) C07D 419/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230094838 | Sparr et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SRI International (Menlo Park, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert H. Sparr (San Carlos, California); Jesse Wodin (Denver, Colorado); Justin D. Landrum (San Francisco, California); Joseph M. Strus (Redwood City, California); Boskin Erkocevic (Superior, Colorado); Jacob M. Cooper (Santa Clara, California); David Watt (Superior, Colorado); Joshua A. Arndt (Great Mills, Maryland) |
| ABSTRACT | Systems and methods for clock synchronization are disclosed. A client synchronization system (CSS) may transmit RF pulses to a server CSS over micrometeorite ionization trail (MMIT) channels, and may receive RF pulses from the server CSS over MMIT channels, each received RF pulse following transmitted RF pulse. The client CSS may receive from the server CSS over MMIT channels measurement data including pulse arrival times at the server CSS. The measurement and transmission data may be correlated to identify RF-pulse pairs, each pairing a transmitted RF pulse received by the server CSS with a received RF pulse received from the server CSS, both over the same MMIT. TWTT analysis may be applied to timing data the pairs to compute time offsets between a client clock and a server clock. An analytical model of clock drift may be applied to the offsets to synchronize the client clock to the server clock. |
| FILED | Wednesday, June 08, 2022 |
| APPL NO | 17/835148 |
| CURRENT CPC | Transmission H04B 7/145 (20130101) Wireless Communication Networks H04W 56/005 (20130101) Original (OR) Class H04W 56/0015 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230095024 | Redding et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brandon F. Redding (University Park, Maryland); Clay Kingsley Kirkendall (Fairfax, Virginia) |
| ABSTRACT | Multiplexed fiber optic sensors are able to monitor a multitude of sensor positions along an optical fiber from a single interrogation point. A long-standing goal is to increase the length of fiber and the number of multiplexed sensors without significantly compromising performance or increasing the size, weight, power and cost of the fiber and interrogation system. A technique is provided for performing extremely long-range, multiplexed fiber optic strain sensing in an efficient manner. This technique utilizes a serial optical frequency comb based interrogation system to probe an array of sensors placed along a single optical fiber. |
| FILED | Wednesday, September 28, 2022 |
| APPL NO | 17/935958 |
| CURRENT CPC | Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/246 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230095206 | CLEMENTS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BALDWIN JIMEK AB (Arlöv, Sweden) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wesley CLEMENTS (Arlöv, Sweden); Birger HANSSON (Arlöv, Sweden); Frank MÅNSSON (Arlöv, Sweden); Patrik MÅNSSON (Arlöv, Sweden); Daniel PERSSON (Arlöv, Sweden) |
| ABSTRACT | A spray applicator (1) for spraying a fluid onto a web (W) of material has a first group of spray nozzles (10A) arranged along a first axis (FA) and a second group of spray nozzles (11A) arranged along a second axis (SA). The first (FA) and second (SA) spray nozzle axes are arranged on the same side of a plane in which the web (W) is run. Each spray nozzle (10A, 11A) has an elongated spray opening configured to spray fluid in a direction towards the web (W). The first spray nozzle opening of the first group of spray ozzles (10A) has an inclination angle which differs from the second nozzle opening inclination angle of the second group of spray nozzles (11A). |
| FILED | Monday, February 01, 2021 |
| APPL NO | 17/802011 |
| CURRENT CPC | Spraying Apparatus; Atomising Apparatus; Nozzles B05B 1/044 (20130101) B05B 1/083 (20130101) B05B 12/04 (20130101) B05B 12/126 (20130101) B05B 13/0278 (20130101) Original (OR) Class B05B 14/30 (20180201) Treating Textile Materials Using Liquids, Gases or Vapours D06B 1/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230095207 | Pawlowski et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Robert Pawlowski (Beaverton, Oregon); Fabio Checconi (Santa Clara, California); Fabrizio Petrini (Menlo Park, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Pawlowski (Beaverton, Oregon); Fabio Checconi (Santa Clara, California); Fabrizio Petrini (Menlo Park, California) |
| ABSTRACT | A memory architecture may provide support for any number of direct memory access (DMA) operations at least partially independent of the CPU coupled to the memory. DMA operations may involve data movement between two or more memory locations and may involve minor computations. At least some DMA operations may include any number of atomic functions, and at least some of the atomic functions may include a corresponding return value. A system includes a first direct memory access (DMA) engine to request a DMA operation. The DMA operation includes an atomic operation. The system also includes a second DMA engine to receive a return value associated with the atomic operation and store the return value at a source memory. |
| FILED | Friday, September 24, 2021 |
| APPL NO | 17/485102 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/52 (20130101) Original (OR) Class G06F 9/30101 (20130101) G06F 13/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230095380 | Yalla et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rosalind Franklin University of Medicine and Science (North Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sai V. Yalla (North Chicago, Illinois); Sunjung Kim (North Chicago, Illinois); Noah J. Rosenblatt (North Chicago, Illinois) |
| ABSTRACT | The present disclosure relates to a system for repetitive loading of a prosthetic socket to test the durability of the prosthetic socket. The system includes a base and a load cell coupled to the base. The system further includes a first coupling mechanism positioned vertically above the load cell, and a second coupling mechanism positioned vertically above the first coupling mechanism. The first coupling mechanism is configured to be removably coupled to a first end of the prosthetic socket, and the second coupling mechanism is configured to be removably coupled to a second end of the prosthetic socket. The system further includes a rod having a first end and a second end opposite the first end. The first end of the rod is coupled to the second coupling mechanism. The system further includes a motor coupled to the second end of the rod, a support structure extending vertically from the base, and an actuator coupled to the support structure such that the actuator is positioned vertically above the second coupling mechanism. The system further includes a curved rail coupled to the actuator and positioned between the actuator and the second coupling mechanism. The curved rail is configured to contact the second coupling mechanism along an arc defined by the curved rail such that the second coupling mechanism moves along the arc when the motor moves the rod. |
| FILED | Thursday, September 29, 2022 |
| APPL NO | 17/936539 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/76 (20130101) Original (OR) Class A61F 2002/7635 (20130101) A61F 2002/7695 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 3/06 (20130101) G01N 3/08 (20130101) G01N 3/32 (20130101) G01N 2203/0005 (20130101) G01N 2203/06 (20130101) G01N 2203/0019 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230095501 | Tassev |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vladimir Tassev (Beavercreek, Ohio) |
| ABSTRACT | A method of performing HVPE heteroepitaxy comprises exposing a substrate to a carrier gas, a first precursor gas, a Group II/III element, and ternary-forming gasses (V/VI group precursor), to form a heteroepitaxial growth of a binary, ternary, and/or quaternary compound on the substrate; wherein the carrier gas is Hz, wherein the first precursor gas is HCl, the Group II/III element comprises at least one of Zn, Cd, Hg, Al, Ga, and In; and wherein the ternary-forming gasses comprise at least two or more of AsH3 (arsine), PH3 (phosphine), H2Se (hydrogen selenide), HzTe (hydrogen telluride), SbH3 (hydrogen antimonide, or antimony tri-hydride, or stibine), H2S (hydrogen sulfide), NH3 (ammonia), and HF (hydrogen fluoride); flowing the carrier gas over the Group II/III element; exposing the substrate to the ternary-forming gasses in a predetermined ratio of first ternary-forming gas to second ternary-forming gas (1tf:2tf ratio); and changing the 1tf:2tf ratio over time. |
| FILED | Monday, October 17, 2022 |
| APPL NO | 18/046946 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/024 (20130101) H01L 21/02387 (20130101) H01L 21/02538 (20130101) H01L 21/02551 (20130101) H01L 21/02568 (20130101) H01L 21/02658 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230095861 | Sailor et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael J. Sailor (La Jolla, California); Byungji Kim (Cambridge, Massachusetts); Jinyoung Kang (La Jolla, California) |
| ABSTRACT | The disclosure describes a fusogenic liposome-coated porous silicon nanoparticles for high loading efficiency of anionic payloads (small molecules, dyes, nucleic acids), and for non-endocytic delivery of hydrophilic and lipophilic payloads by membrane fusion. The liposome coating can be further modified with targeting peptides or antibodies via covalent binding chemistry between the ligands and functionalized poly(ethylene glycol). The surface moieties can be transferred to the cellular membrane surface by fusogenic uptake. The composition of the disclosure can be applied in the treatment of diseases by delivering entrapped/encapsulated payloads. |
| FILED | Friday, July 22, 2022 |
| APPL NO | 17/871768 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 9/0051 (20130101) A61K 9/1271 (20130101) A61K 9/1272 (20130101) Original (OR) Class A61K 9/5115 (20130101) A61K 31/713 (20130101) A61K 47/64 (20170801) A61K 47/6923 (20170801) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) B82Y 30/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230096016 | Bassett et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rowan University (Glassboro, New Jersey); The United States of America as Represented by the Secretary of the Army (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander W. Bassett (Mullica Hill, New Jersey); Joseph F. Stanzione, III (Wilmington, Delaware); John J. La Scala (Wilmington, Delaware) |
| ABSTRACT | Resins and formulations of individual monomers bearing both vinyl ester and epoxy functionality were either synthesized or formulated such that vinyl ester components capable of polymerizing by photo-induced, free radical polymerization were mixed with step-growth epoxy-amine systems, facilitating sequential cure. The vinyl ester component was photopolymerized using vat photopolymerization (VPP). Additionally, the preparation of bio-based photo curable thermosetting resins that have tailorable thermal and mechanical properties is provided. All monomers and polymers described herein are useful in a variety of applications, including additive manufacturing applications. |
| FILED | Thursday, February 18, 2021 |
| APPL NO | 17/799982 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 220/1806 (20200201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230096203 | Garcia Hernandez et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vicky Garcia Hernandez (Ann Arbor, Michigan); Amnah Yamani (Ann Arbor, Michigan); Asma Nusrat (Ann Arbor, Michigan); Simon Patrick Hogan (Ann Arbor, Michigan) |
| ABSTRACT | Provided herein are methods for determining the presence of desmoglein-2 protein fragments in a sample obtained from a subject suspected of having a food allergy, as well as methods of treating a food allergy. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/795895 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/137 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/08 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) G01N 2333/705 (20130101) G01N 2800/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230096431 | Sottos et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | Nancy R. Sottos (Champaign, Illinois); Jeffrey S. Moore (Savoy, Illinois); Leon M. Dean (Minneapolis, Minnesota); Qiong Wu (Champaign, Illinois); Omar Alshangiti (Urbana, Illinois) |
| ABSTRACT | A method of rapidly forming an elastomer with tunable properties is described herein. The method includes preparing a monomer solution comprising a catalyst and one or more monomers including 1,5-cyclooctadiene (COD). The one or more monomers may further include dicyclopentadiene (DCPD), and each of the COD and the DCPD may be present in the monomer solution at a predetermined volume percentage. A region of the monomer solution is activated to initiate an exothermic polymerization reaction and generate a self-propagating polymerization front, which moves through the monomer solution and polymerizes the one or more monomers. Thus, an elastomer having predetermined properties is rapidly formed. |
| FILED | Wednesday, March 10, 2021 |
| APPL NO | 17/910132 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/22 (20130101) Original (OR) Class Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 61/08 (20130101) C08G 2261/3321 (20130101) C08G 2261/3322 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230096503 | Oskotsky et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| ASSIGNEE(S) | BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| INVENTOR(S) | Mark L. Oskotsky (Mamaroneck, New York); Jacob D. Garan (Honolulu, Hawaii); Morgan Jolley (Commack, New York); Daniel N. Kokubun (Waipahu, Hawaii); Michael J. Russo (Roslyn, New York) |
| ABSTRACT | An athermal and achromatic lens with a high resolution while further being near orthoscopic and providing a large field of view. Further, the provided VNIR lens may utilize only three types of optical glass allowing the lens to be reduced in size, cost, and weight while further reducing or minimizing the complexity thereof. |
| FILED | Tuesday, September 28, 2021 |
| APPL NO | 17/487758 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 13/06 (20130101) G02B 13/14 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/14627 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230096585 | Ke et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yanjing Ke (Union City, California); Yew Fatt Kok (Newark, California) |
| ABSTRACT | The present disclosure is directed to improving compatibility between chiplets integrated with disparate chiplet interfaces. To reduce compatibility issues due non-matching bump maps, a dual-mode bump map assignment may be implemented to enable a chiplet to utilize multiple signal number sequence assignments. Additionally, a modularized Advanced Interface Bus (AIB) interface may be implemented to reduce channel mismatch in AIB -UCIe multi-channel interoperability. |
| FILED | Monday, December 05, 2022 |
| APPL NO | 18/075183 |
| CURRENT CPC | Electric Digital Data Processing G06F 13/4004 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230096704 | Sayour et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elias Sayour (Newberry, Florida); Hector Ruben Mendez-Gomez (Gainesville, Florida); Sadeem Qdaisat (Gainesville, Florida); Loic Pierre Deleyrolle (Gainesville, Florida); Duane A. Mitchell (Gainesville, Florida) |
| ABSTRACT | Provided herein are compositions comprising a liposome comprising ribonucleic acid (RNA) molecules and a cationic lipid, wherein the RNA molecules bind to or encode an epitope of a nucleic acid encoding a fusion protein expressed by a tumor. The disclosure also provides a nanoparticle comprising a positively-charged surface and an interior comprising (i) a core and (ii) at least two nucleic acid layers, wherein each nucleic acid layer is positioned between a cationic lipid bilayer, and nucleic acid molecules in the nucleic acid layers comprise a sequence of a nucleic acid molecule expressed by slow-cycling cells (SCCs). Also provided herein re methods of making a nanoparticle and methods of increasing an immune response against a tumor in a subject. Methods of treating a subject with a disease are provided herein. |
| FILED | Friday, February 05, 2021 |
| APPL NO | 17/797810 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1272 (20130101) A61K 9/1278 (20130101) A61K 39/001196 (20180801) Original (OR) Class A61K 2039/5154 (20130101) A61K 2039/6018 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/4748 (20130101) C07K 2319/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230096860 | Cambou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of Northem Arizona University (Flagstaff, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bertrand F. Cambou (Flagstaff, Arizona); Julie Heynssens (Flagstaff, Arizona); Ian Burke (Flagstaff, Arizona); Brit Riggs (Flagstaff, Arizona); Jack Garrard (Flagstaff, Arizona); Manuel Aguilar Rios (Flagstaff, Arizona); Donald Telesca (Rome, New York); H. Shelton Jacinto (Rome, New York) |
| ABSTRACT | Systems and methods for the generation and use of session keys supporting secure communications between a client and server device are disclosed. The client hashes each of a series of passwords a first number of times. The hashed passwords are sent to a server. The server applies the hashed password to an array of PUF devices, and receives an initial response bitstream which is stored. The client later hashes each of the series of passwords a second number of times, which is less than the first number, and these are sent to the server. The server continues to hash the second message digest, generate PUF responses, and compare the result to the initially stored responses. For each password, the number of hashes necessary to achieve a match is a partial session key. Latency is improved by an array of separately addressable PUFs, each producing a partial session key. |
| FILED | Tuesday, September 27, 2022 |
| APPL NO | 17/954222 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0863 (20130101) H04L 9/3239 (20130101) H04L 9/3268 (20130101) H04L 9/3278 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230097147 | Montalvo-Bartolomei et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America as Represented by the Secretary of the Army (Alexandria, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Axel M. Montalvo-Bartolomei (Vicksburg, Mississippi); Bryant A. Robbins (Lakewood, Colorado) |
| ABSTRACT | In one embodiment, a sand boil filter apparatus has a filter cone including an inner cone mesh and an outer cone mesh, the inner cone mesh having a finer mesh than the outer cone mesh. A filter tube extends through the hollow interior of the filter cone. The filter tube includes a lower portion disposed below the open apex. The filter tube includes an upper portion disposed above the open base. The upper portion has a plurality of sets of exit openings which are spaced along a length of the upper portion to provide different possible exit heights for the plurality of sets of exit openings, each set including one or more exit openings disposed at an exit height of the filter tube. An exit height adjustment tool blocks all of the exit openings disposed below a set of unblocked exit openings selected to provide a corresponding exit height. |
| FILED | Wednesday, September 29, 2021 |
| APPL NO | 17/488301 |
| CURRENT CPC | Separation B01D 29/15 (20130101) B01D 29/085 (20130101) Original (OR) Class B01D 2201/02 (20130101) Foundations; Excavations; Embankments; Underground or Underwater Structures E02D 3/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230097179 | Strandjord et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Honeywell International Inc. (Morris Plains, New Jersey) |
| ASSIGNEE(S) | Honeywell International Inc. (Morris Plains, New Jersey) |
| INVENTOR(S) | Lee K. Strandjord (Tonka Bay, Minnesota); Tiequn Qiu (Glendale, Arizona); Glen A. Sanders (Scottsdale, Arizona) |
| ABSTRACT | Systems and methods for reducing rotation sensing errors from laser source signal and modulation cross-talk are provided herein. An RFOG includes a fiber optic resonator; a first laser source that produces a first light wave at a first carrier frequency and a first cross-talked portion at a second carrier frequency wave for propagating in a first direction, wherein a second cross-talked portion propagates in a second direction that is opposite to the first direction; a second laser source that produces a second light wave for propagating in the second direction at a second carrier frequency, and having a third cross-talked portion that propagates in the first direction, a first modulator that modulates the first light wave by suppressing light at the first carrier frequency and the second cross-talked portion at the second carrier frequency, and photodetectors that generate signals from the modulated first light wave and the second light wave. |
| FILED | Tuesday, August 04, 2020 |
| APPL NO | 16/984855 |
| CURRENT CPC | Transmission H04B 10/2563 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230097526 | Weiland |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Christopher J. Weiland (King George, Virginia) |
| ASSIGNEE(S) | United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Christopher J. Weiland (King George, Virginia) |
| ABSTRACT | A method is provided for producing a vortex ring in a liquid medium. The method includes concatenating pairs of insulated anode and cathode rings into a stack; inserting the stack into a vertically oriented chamber; disposing a cylindrical cavity below the chamber; inserting a piston into the cavity; connecting the chamber to the medium; and raising the piston to displace the medium while the stack produces an annular bubble that induces the vortex ring. In particular, the medium is water and the stack separates the medium into hydrogen and oxygen gas. |
| FILED | Wednesday, September 29, 2021 |
| APPL NO | 17/489438 |
| CURRENT CPC | Fluid Dynamics, i.e Methods or Means for Influencing the Flow of Gases or Liquids F15D 1/009 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230097722 | Brewer |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Micro Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tony Brewer (Plano, Texas) |
| ABSTRACT | Implementations of the present disclosure are directed to systems and methods for reducing the size of packet headers by using a single field to encode multiple elements. Instead of including separate fields for each element, one or more encoded fields may be used, each of which is decoded to determine two or more values for the data packet. A receiving device decodes the encoded data field to retrieve the two or more values. |
| FILED | Friday, November 18, 2022 |
| APPL NO | 17/990467 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 45/302 (20130101) H04L 45/745 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230097887 | Spiegel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Spiegel (New Haven, Connecticut); David Caianiello (Brooklyn, New York) |
| ABSTRACT | Described herein is a bi-functional compound for removing macrophage migration inhibitory factor (MIF) or immunoglobin G (IgG). Further described herein is a pharmaceutical composition which comprise these bi-functional compounds. Further described herein is a method for treating disease states and/or conditions with the compounds or the composition. The disease states and/or conditions are mediated through MIF/IgG or where MIF/IgG is a contributing factor to the development and perpetuation of diseases and/or conditions, such as autoimmune diseases and cancer, among others. |
| FILED | Tuesday, March 15, 2022 |
| APPL NO | 17/695259 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) A61K 47/55 (20170801) Original (OR) Class A61K 47/545 (20170801) A61K 47/549 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230097946 | Slichter |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BLOODWORKS (SEATTLE, Washington) |
| ASSIGNEE(S) | BLOODWORKS (SEATTLE, Washington) |
| INVENTOR(S) | Sherrill J. Slichter (Vashon, Washington) |
| ABSTRACT | Methods and compositions for the prevention or reduction of platelet transfusion associated complications are provided. The subject methods include modifying donor whole blood or platelets prior to transfusion to prevent or reduce alloimmune platelet refractoriness. |
| FILED | Wednesday, September 28, 2022 |
| APPL NO | 17/955515 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0215 (20130101) A01N 1/0294 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 35/14 (20130101) A61K 41/17 (20200101) Original (OR) Class Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 2/0047 (20130101) A61L 2/0076 (20130101) A61L 2202/11 (20130101) A61L 2202/22 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/0281 (20130101) A61M 1/3683 (20140204) A61M 2202/0427 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230098149 | Chilkoti et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ashutosh Chilkoti (Durham, North Carolina); Jacob Heggestad (Durham, North Carolina); David Kinnamon (Durham, North Carolina); Angus Hucknall (Durham, North Carolina) |
| ABSTRACT | Disclosed herein are devices that can be used to detect neutralizing antibodies against multiple pathogens in a quick and accurate manner. An example device includes a substrate; a non-fouling layer; a plurality of pathogen regions, each pathogen region including a different pathogen; and at least one detection region, the detection region including a detection agent that is capable of specifically binding each pathogen and an excipient. In addition, an example method includes contacting a biological sample with a device, and detecting the presence of a neutralizing antibody in the biological sample for each pathogen, wherein the presence of the neutralizing antibody is detected by inhibiting the binding of the detection agent to each pathogen. |
| FILED | Friday, September 30, 2022 |
| APPL NO | 17/957373 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 33/56983 (20130101) Original (OR) Class G01N 2021/6439 (20130101) G01N 2333/165 (20130101) G01N 2469/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230098194 | JOHNSON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Terumo BCT Biotechnologies, LLC (Lakewood, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nathaniel T. JOHNSON (Highlands Ranch, Colorado); Dennis A. BRIDGES (Arvada, Colorado); Alexander Du NGUYEN (Denver, Colorado); Margaret V. KWIAT (Evergreen, Colorado); Kestas P. PARAKININKAS (Englewood, Colorado); Rylan A. SUMMIT (Denver, Colorado) |
| ABSTRACT | Provided is a loading tray assembly for housing a lyophilization container and a related system and method. The loading tray assembly includes a chassis including a contact void configured to facilitate direct contact between the attached lyophilization container and a lyophilizer shelf. The method includes securing a multi-part lyophilization container including a peelable seal on a lyophilization loading tray assembly, inputting a liquid into a non-breathable section of the lyophilization container, loading the tray assembly into a lyophilizer, freezing the liquid, applying heat energy and a vacuum, the vacuum causing an opening of the peelable seal and occluding the lyophilization container to isolate the frozen liquid. |
| FILED | Thursday, December 01, 2022 |
| APPL NO | 18/073217 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0263 (20130101) A01N 1/0284 (20130101) A01N 1/0289 (20130101) Containers Specially Adapted for Medical or Pharmaceutical Purposes; Devices or Methods Specially Adapted for Bringing Pharmaceutical Products into Particular Physical or Administering Forms; Devices for Administering Food or Medicines Orally; Baby Comforters; Devices for Receiving Spittle A61J 1/10 (20130101) A61J 1/1468 (20150501) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/0277 (20140204) A61M 2202/0415 (20130101) A61M 2205/584 (20130101) A61M 2205/3389 (20130101) Drying Solid Materials or Objects by Removing Liquid Therefrom F26B 5/06 (20130101) Original (OR) Class F26B 21/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230098464 | Haas et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States, as represented by the Secretary of the Navy (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bryan Haas (Arnold, Maryland); Jason McKinney (Bowie, Maryland) |
| ABSTRACT | Methods and apparatuses for downconverting high frequency subbands to a lower frequency band and recovering signals-of interest. The system includes a controller, a signal generator, an optical source, a dual-drive mach zehnder modulator (DDMZM), a photodetector, and a dechipping/image (DI) rejector. The controller outputs chipping frequencies to the signal generator which generates local oscillator (LO) tones shifted by the respective chipping frequencies. The optical source outputs an optical signal to the DDMZM which has first and second arms and modulators. The first modulator receives a signal from a source and modulates it onto the optical signal propagating through the first arm to form a first modulated optical signal. The second modulator receives the shifted local oscillator tones and modulates them onto the optical signal propagating through the second arm to form a second modulated optical signal. The DDMZM outputs a signal which is a combination of the first and second modulated optical signals to the photodetector which generates a corresponding electrical signal. The dechipping/image (DI) rejector receives the electrical signal and one of the chipping frequencies and outputs a signal that maximizes signals in one high frequency subband while suppressing signals in other high frequency subbands. |
| FILED | Friday, September 30, 2022 |
| APPL NO | 17/958276 |
| CURRENT CPC | Transmission H04B 1/1036 (20130101) Original (OR) Class H04B 10/505 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230098583 | Francis et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University Of Cincinnati (Cincinnati, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jessica Francis (New Vienna, Ohio); Mikel Larson (Cincinnati, Ohio); Michelle D. Hoffman (Wyoming, Ohio); Eliot Gomez (Cincinnati, Ohio); Jason Charles Heikenfeld (Cincinnati, Ohio); Isaac Stamper (Morrow, Ohio) |
| ABSTRACT | A device for determining the amount or concentration of an analyte in a fluid sample and a flow rate of the fluid sample in a channel is provided. The device includes a chamber including a channel and an opening, the channel in fluid communication with the opening. The device further includes a wicking component positioned adjacent to the opening configured to receive an amount of fluid from the channel. The device may further include an analyte sensor positioned on the wicking component, the analyte sensor configured to detect an analyte in fluid in contact with the analyte sensor, wherein the wicking component is configured to contact the amount of fluid with the analyte sensor. Alternatively the device may include at least one pair of electrodes configured to determine a flow rate of the fluid in the channel. |
| FILED | Thursday, November 03, 2022 |
| APPL NO | 18/052398 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/14507 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230098991 | Nieh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Jason Nieh (New York, New York); Alexander Edward Van't Hof, III (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason Nieh (New York, New York); Alexander Edward Van't Hof, III (New York, New York) |
| ABSTRACT | Mechanisms for protecting an application from an untrusted operating system (OS) are provided, the methods including: determining that a virtual address for a page of memory allocated by the untrusted OS for the application belongs to a valid mapping; determining that the page of memory is not already in use; and in response to determining that the virtual address for the page of memory belongs to a valid mapping and determining that the page of memory is not already in use, mapping the page of memory to an enclaved container for the application. Some mechanisms further include unmapping the page of memory from the untrusted OS. In some mechanism, determining that the virtual address for the page of memory belongs to a valid mapping is based on a list of valid mappings for the application. |
| FILED | Thursday, May 19, 2022 |
| APPL NO | 17/749115 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/6281 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230099698 | Nikonchuk et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States of America as represented by the Secretary of the Army (Washington, District of Columbia) |
| ASSIGNEE(S) | United States of America as represented by the Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | William P. Nikonchuk (Huntsville, Alabama); Geoffrey P. Suiter (Huntsville, Alabama) |
| ABSTRACT | The chilling system provides cooling to components housed within a container by pumping propylene-glycol-water-mixture (PGWM) or equivalent through heat exchange assemblies and thermal transfer vessels. The thermal transfer vessels are filled with a paraffin-based phase change material (PCM) or equivalent solution for realizing phase change of the PCMs at selected melting points. The heat exchange assemblies are provided with thermal electric coolers for cooling the PGWM as it travels through the heat exchangers. The cooled PGWM is directed into and through a target cooling manifold of a target heat exchanger assembly to realize cooling the housed components. The system operates on direct current at under 500 watts of power and requires no Freon-type refrigerants or compressors. A microcontroller controls switches for realizing desired flow paths of the PGWM upon receiving phase change and temperature information from sensors. |
| FILED | Tuesday, September 20, 2022 |
| APPL NO | 17/948309 |
| CURRENT CPC | Refrigeration Machines, Plants or Systems; Combined Heating and Refrigeration Systems; Heat-pump Systems F25B 21/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230100186 | Torres et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland); The Government of The United States, as represented by The Secretary of The Army (Fort Detrick, Maryland); The United States of America, as represented by the Secretary, Department of Health and Human Serv (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Oscar Torres (Silver Spring, Maryland); Gary R. Matyas (Silver Spring, Maryland); Kenner C. Rice (Rockville, Maryland); Eric W. Bow (Rockville, Maryland); Agnieszka Sulima (Rockville, Maryland); Arthur E. Jacobson (Rockville, Maryland) |
| ABSTRACT | Described is the preparation of novel fentanyl haptens of Formula (1) through (6) and their use in the preparation of effective fentanyl vaccines. |
| FILED | Wednesday, January 13, 2021 |
| APPL NO | 17/792378 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0013 (20130101) A61K 39/39 (20130101) A61K 39/385 (20130101) Original (OR) Class A61K 2039/6037 (20130101) A61K 2039/6081 (20130101) A61K 2039/55505 (20130101) A61K 2039/55555 (20130101) A61K 2039/55572 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/36 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230100277 | Tassev |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vladimir Tassev (Beavercreek, Ohio) |
| ABSTRACT | A method of performing HVPE heteroepitaxy comprises exposing a substrate to a carrier gas, a first precursor gas, a Group II/III element, and ternary-forming gasses (V/VI group precursor), to form a heteroepitaxial growth of a binary, ternary, and/or quaternary compound on the substrate; wherein the carrier gas is H2, wherein the first precursor gas is HCl, the Group II/III element comprises at least one of Zn, Cd, Hg, Al, Ga, and In; and wherein the ternary-forming gasses comprise at least two or more of AsH3 (arsine), PH3 (phosphine), H2Se (hydrogen selenide), H2Te (hydrogen telluride), SbH3 (hydrogen antimonide, or antimony tri-hydride, or stibine), H2S (hydrogen sulfide), NH3 (ammonia), and HF (hydrogen fluoride); flowing the carrier gas over the Group II/III element; exposing the substrate to the ternary-forming gasses in a predetermined ratio of first ternary-forming gas to second ternary-forming gas (1tf:2tf ratio); and changing the 1tf:2tf ratio over time. |
| FILED | Friday, October 14, 2022 |
| APPL NO | 18/046529 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/024 (20130101) H01L 21/02387 (20130101) H01L 21/02538 (20130101) H01L 21/02551 (20130101) H01L 21/02568 (20130101) H01L 21/02658 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230101340 | HOSSEINI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kaveh HOSSEINI (San Jose, California); Omkar KARHADE (Chandler, Arizona); Ravindranath V. MAHAJAN (Chandler, Arizona); Sergey Yuryevich SHUMARAYEV (Los Altos Hills, California); Yew F. KOK (Newark, California); Sai VADLAMANI (Gilbert, Arizona) |
| ABSTRACT | Embodiments disclosed herein include electronic packages and methods of assembling an electronic package. In an embodiment, an electronic package comprises a package substrate with a stepped top surface, and a first die on a first plateau of the stepped top surface. In an embodiment, a second die is on a second plateau of the stepped top surface, where the second die extends over the first die, In an embodiment, a third die is on a third plateau of the stepped top surface, where the third die extends over the second die. |
| FILED | Friday, September 24, 2021 |
| APPL NO | 17/485295 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/485 (20130101) H01L 24/16 (20130101) H01L 24/32 (20130101) H01L 24/73 (20130101) H01L 24/81 (20130101) H01L 24/83 (20130101) H01L 25/50 (20130101) H01L 25/0657 (20130101) Original (OR) Class H01L 2224/16145 (20130101) H01L 2224/16225 (20130101) H01L 2224/32225 (20130101) H01L 2224/73204 (20130101) H01L 2225/06513 (20130101) H01L 2225/06517 (20130101) H01L 2225/06541 (20130101) H01L 2225/06562 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230101802 | Knight et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Kaney Aerospace, Inc. (Rockford, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Donald Fredrick Knight (Davis, Illinois); Erik Michael Plugge (Rockford, Illinois) |
| ABSTRACT | Magnetic cycloidal gear assemblies and mounting arrangements for magnetic cycloidal gear assemblies are provided that include a fixed stator and a cycloid that rotates eccentrically within the stator. The cycloid can be mounted to an offset cam on the input shaft by a rolling element bearing. A plurality of cam followers connect the cycloid to the output hub. Various features can be provided to increase operational balance or stability. For example, an adjustable counterweight can be attached to the input shaft. Also for example, a mounting arrangement including an adjustable nut, one or more bearings, and/or one or more wave springs can be provided to allow for the application, balancing, or adjustment of axial forces within the assembly. |
| FILED | Tuesday, September 28, 2021 |
| APPL NO | 17/487898 |
| CURRENT CPC | Dynamo-electric Machines H02K 49/102 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230101827 | Romain et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| ASSIGNEE(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| INVENTOR(S) | Gaume Romain (Orlando, Florida); Matthew Julian (Merritt Island, Florida) |
| ABSTRACT | A crucible for a thermogravimetric analysis (TGA) system can include a side wall defining a crucible opening, and a base enclosed by side wall and opposite the crucible opening. The base and side wall form an interior volume configured to hold a material for thermogravimetric analysis. The base can include a base shape configured to prevent a center of mass of the material within the crucible from shifting during thermogravimetric analysis. |
| FILED | Tuesday, September 28, 2021 |
| APPL NO | 17/488074 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 5/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230102143 | Murray et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America as Represented by The Secretary of The Army (Alexandria, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew P Murray (Vicksburg, Mississippi); Gary E Johnston (Vicksburg, Mississippi); David A Nguyen (Vicksburg, Mississippi); Christopher M Ables (Vicksburg, Mississippi); Thad C Pratt (Vicksburg, Mississippi) |
| ABSTRACT | In one embodiment, a female wedge mount is attached to a first surface vehicle. The female wedge mount has a concave contact surface including three or more female contact surface segments an at least two female wedge slots. A male wedge mount is attached to the second surface vehicle. The male wedge mount has a convex contact surface including three or more male contact surface segments and at least two male wedge slots that are aligned with the at least two female wedge slots, respectively, when the convex contact surface of the male wedge mount and the concave contact surface of the female wedge mount are in aligned contact with one another to form an adjacent connection between the first and second surface vehicles. A mechanism includes at least two pins that are movable along the at least two male and female wedge slots, respectively, between unlocked and locked positions. |
| FILED | Tuesday, September 28, 2021 |
| APPL NO | 17/486934 |
| CURRENT CPC | Construction of Bridges, or Viaducts; Assembly of Bridges E01D 15/133 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230102402 | Wood |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America as Represented by The Secretary of the Army (Alexandria, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tanner J. Wood (Champaign, Illinois) |
| ABSTRACT | The disclosure relates to a connector assembly including a male connector and a female connector that are connectable to each other. The male connector includes a connector main body having an annular shape and a plurality of male nubs arranged circumferentially around the connector main body, each male nub configured to be received by a corresponding female slot. The female connector includes a main body portion having an annular shape and a plurality of female slots arranged circumferentially around the main body portion, each female slot configured to receive a corresponding male nub. The male connector and female connector are configured such that when the male connector is connected to the female connector, the plurality of male nubs engages with respective ones of the plurality of female slots. The connector system is particularly applied to link building components together to form structural elements. |
| FILED | Wednesday, September 29, 2021 |
| APPL NO | 17/488824 |
| CURRENT CPC | General Building Constructions; Walls, e.g Partitions; Roofs; Floors; Ceilings; Insulation or Other Protection of Buildings E04B 1/40 (20130101) Devices for Fastening or Securing Constructional Elements or Machine Parts Together, e.g Nails, Bolts, Circlips, Clamps, Clips, Wedges, Joints or Jointing F16B 7/0426 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230103072 | FLOYD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTH CAROLINA (Columbia, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | RICHARD FLOYD (WEST COLUMBIA, South Carolina); ASIF KHAN (IRMO, South Carolina); MIKHAIL GAEVSKI (WEST COLUMBIA, South Carolina); MVS CHANDRASHEKHAR (COLUMBIA, South Carolina); GREGORY SIMIN (COLUMBIA, South Carolina) |
| ABSTRACT | A 1.8-times improved light extraction efficiency (LEE) is reported under DC test conditions for truncated cone AlGaN DUV micropixel LEDs when the pixel size was reduced from 90 to 5 µm. This is shown to be a direct consequence of the absorption of the TM-polarized photons travelling in a direction parallel to the device epitaxial layers. Presently disclosed cathodoluminescence measurements show the lateral absorption length for 275 nm DUV photons to be 15 µm, which is ~1000 times shorter than that for waveguiding in the A0.65Ga0.35N cladding layers. Results show the re-absorption of this laterally travelling emission by the multiple quantum wells and the p-contact GaN layer to be a key factor limiting the LEE. Hence, for DUV emitters, scaling down to sub-20 µm device dimensions is critical for maximizing LEE. Presently disclosed sub-20 µm AIGaN-based LEDs do not show pronounced edge recombination effects. The peak light output power was further increased for all the devices after the addition of a semi -reflective Al2O3/Al heat spreader despite the reduction in sidewall reflectivity. |
| FILED | Wednesday, May 18, 2022 |
| APPL NO | 17/747351 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/156 (20130101) H01L 33/32 (20130101) H01L 33/62 (20130101) Original (OR) Class H01L 33/0075 (20130101) H01L 33/641 (20130101) H01L 2933/0066 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230103140 | ZHANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (East Lansing, Michigan) |
| ASSIGNEE(S) | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (East Lansing, Michigan) |
| INVENTOR(S) | Peng ZHANG (Okemos, Michigan); Lin WU (Jadescape, Singapore); Xiao XIONG (The Tennery, Singapore); Yang ZHOU (Lansing, Michigan) |
| ABSTRACT | A dielectric coated plasmonic photoemitter is provided. An aspect of the present photonic apparatus includes a conductive photoemitter including a dielectric material coating or layered on a metallic core. The dielectric material being configured to enhance a local optical field strength and current density of the photoemitter as compared to a bare photoemitter without the dielectric layer. The dielectric layered photoemitter being tunable to transmit photoemissions from corners thereof with different photonic characteristics depending on a laser wavelength pulse received. |
| FILED | Friday, May 20, 2022 |
| APPL NO | 17/749360 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 1/34 (20130101) Original (OR) Class H01J 23/04 (20130101) H01J 25/34 (20130101) H01J 37/26 (20130101) H01J 37/073 (20130101) Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 7/02 (20130101) H05H 7/22 (20130101) H05H 9/00 (20130101) H05H 15/00 (20130101) H05H 2007/025 (20130101) H05H 2007/225 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20230094133 | FORREST et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | Regents of the University of Michigan (Ann Arbor, Michigan) |
| INVENTOR(S) | Stephen R. FORREST (Ann Arbor, Michigan); Yue QU (Ann Arbor, Michigan) |
| ABSTRACT | A number of new solutions for enhancing the extraction of waveguided mode and suppressing surface plasmon polariton mode in OLEDs are disclosed. For example, an OLED is disclosed that includes: a substrate having a first side and a second side; a reflective layer disposed over the first side of the substrate; a grid layer consisting of two optically transparent materials with different refractive indices disposed on the reflective layer; a transparent first electrode provided over the grid layer; an organic emissive layer provided over the transparent first electrode; and a transparent second electrode provided over the organic emissive layer, where the grid layer scatters trapped waveguided modes from the organic emissive layer. |
| FILED | Thursday, November 17, 2022 |
| APPL NO | 18/056414 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/504 (20130101) H01L 51/5072 (20130101) H01L 51/5212 (20130101) H01L 51/5265 (20130101) H01L 51/5268 (20130101) Original (OR) Class H01L 51/5271 (20130101) H01L 51/5275 (20130101) H01L 2251/558 (20130101) H01L 2251/5369 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230094491 | Parish et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Flowserve Management Company (Irving, Texas) |
| ASSIGNEE(S) | Flowserve Management Company (Irving, Texas) |
| INVENTOR(S) | Paul Jeffrey Parish (Spanish Fork, Utah); Michael P. Nelson (Lehi, Utah) |
| ABSTRACT | An apparatus for measuring a pressure of a corrosive or high temperature process liquid includes a pressure sensor in communication with the process liquid via a vertical tube. A buffer gas injected into the vertical tube forms a liquid/gas interface at a desired height. The buffer gas supply is then either isolated or regulated so as to cause the buffer gas pressure within the vertical tube to remain equal with the process liquid pressure. The pressure sensor indirectly measures the process liquid pressure by measuring the buffer gas pressure within the vertical tube, while remaining chemically and thermally protected from the process liquid. In embodiments, pressure measurements from a pair of gas buffered pressure sensors located upstream and downstream of a valve are combined with measurements of the process liquid temperature to determine a flow rate of the process liquid through the valve. |
| FILED | Monday, September 27, 2021 |
| APPL NO | 17/485670 |
| CURRENT CPC | Measuring Volume, Volume Flow, Mass Flow or Liquid Level; Metering by Volume G01F 1/34 (20130101) G01F 1/68 (20130101) Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 19/0627 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230095750 | Burkart et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael D. Burkart (La Jolla, California); Thien An Phung Hai (La Jolla, California) |
| ABSTRACT | The disclosure provides, inter alia, safe and environmentally-friendly methods, such as flow chemistry, to synthesize isocyanates, such as methylene diphenyl diisocyanate, toluene diisocyanate, hexamethylene diisocyanate, isophorone diisocyanate, and tetramethylxylene diisocyanate. |
| FILED | Monday, December 14, 2020 |
| APPL NO | 17/783511 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 243/14 (20130101) C07C 247/02 (20130101) C07C 263/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230095751 | LAHODA |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Westinghouse Electric Company LLC (Cranberry Township, Pennsylvania) |
| ASSIGNEE(S) | Westinghouse Electric Company LLC (Cranberry Township, Pennsylvania) |
| INVENTOR(S) | Edward J. LAHODA (Edgewood, Pennsylvania) |
| ABSTRACT | A method for making an improved nuclear fuel cladding tube includes reinforcing a Zr alloy tube by first winding or braiding ceramic yarn directly around the tube to form a ceramic covering, then physically bonding the ceramic covering to the tube by applying a first coating selected from the group consisting of Nb, Nb alloy, Nb oxide, Cr, Cr oxide, Cr alloy, or combinations thereof, by one of a thermal deposition process or a physical deposition process to provide structural support member for the Zr tube, and optionally applying a second coating and optionally applying a third coating by one of a thermal deposition process or a physical deposition process. If the tube softens at 800° C.-1000° C., the structural support tube will reinforce the Zr alloy tube against ballooning and bursting, thereby preventing the release of fission products to the reactor coolant. |
| FILED | Wednesday, June 29, 2022 |
| APPL NO | 17/809703 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 4/06 (20130101) C23C 4/11 (20160101) C23C 14/18 (20130101) C23C 14/083 (20130101) C23C 24/04 (20130101) Braiding or Manufacture of Lace, Including Bobbin-net or Carbonised Lace; Braiding Machines; Braid; Lace D04C 1/06 (20130101) Nuclear Reactors G21C 3/07 (20130101) Original (OR) Class G21C 3/047 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230095982 | DUDUKOVIC et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nikola DUDUKOVIC (Hayward, California); Rebecca DYLLA-SPEARS (Dublin, California); Megan Elizabeth ELLIS (Jamesport, Missouri) |
| ABSTRACT | The present disclosure relates to a method for forming a glass structure having a metallized surface portion. The method may comprise forming a structure using a flowable first material, adapted to form a glass, which includes a metal component. The structure is then treated to remove substantially all solvents and organic components contained in the first flowable material. Finally, the structure is exposed to a bath of a metal salt during which nucleation occurs and a metallized surface coating is formed on at least a portion of an outer surface of the structure. |
| FILED | Wednesday, September 29, 2021 |
| APPL NO | 17/488453 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) Manufacture, Shaping, or Supplementary Processes C03B 19/06 (20130101) Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials C03C 17/10 (20130101) C03C 2218/13 (20130101) C03C 2218/31 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 18/44 (20130101) C23C 18/1865 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230096046 | KELLERMAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | LEADING EDGE EQUIPMENT TECHNOLOGIES, INC. (Wilmington, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter KELLERMAN (Essex, Massachusetts); Alison GREENLEE (Somerville, Massachusetts); Parthiv DAGGOLU (Danvers, Massachusetts); Alexander MARTINEZ (Woburn, Massachusetts) |
| ABSTRACT | An optical sensor is configured to detect a difference in emissivity between the melt and a solid ribbon on the melt, which may be silicon. The optical sensor is positioned on a same side of a crucible as a cold initializer. A difference in emissivity between the melt and the ribbon on the melt is detected using an optical sensor. This difference in emissivity can be used to determine and control a width of the ribbon. |
| FILED | Friday, February 19, 2021 |
| APPL NO | 17/801198 |
| CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 15/06 (20130101) Original (OR) Class C30B 15/10 (20130101) C30B 15/26 (20130101) C30B 29/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230096431 | Sottos et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | Nancy R. Sottos (Champaign, Illinois); Jeffrey S. Moore (Savoy, Illinois); Leon M. Dean (Minneapolis, Minnesota); Qiong Wu (Champaign, Illinois); Omar Alshangiti (Urbana, Illinois) |
| ABSTRACT | A method of rapidly forming an elastomer with tunable properties is described herein. The method includes preparing a monomer solution comprising a catalyst and one or more monomers including 1,5-cyclooctadiene (COD). The one or more monomers may further include dicyclopentadiene (DCPD), and each of the COD and the DCPD may be present in the monomer solution at a predetermined volume percentage. A region of the monomer solution is activated to initiate an exothermic polymerization reaction and generate a self-propagating polymerization front, which moves through the monomer solution and polymerizes the one or more monomers. Thus, an elastomer having predetermined properties is rapidly formed. |
| FILED | Wednesday, March 10, 2021 |
| APPL NO | 17/910132 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/22 (20130101) Original (OR) Class Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 61/08 (20130101) C08G 2261/3321 (20130101) C08G 2261/3322 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230096521 | Sun et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Uchicago Argonne, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pingping Sun (Downers Grove, Illinois); Theodore R. Krause (Naperville, Illinois); Amgad A. Elgowainy (Lisle, Illinois); Yupo Lin (Naperville, Illinois); Hong Liu (Argonne, Illinois); Hernan Eugenio Delgado de la Garza (Downers Grove, Illinois) |
| ABSTRACT | A method for conversion of food waste to biofuel can include a first fermentation in which food waste is converted C2-C4 short-chain carboxylic acids, and a second fermentation in which the C2-C4 short-chain carboxylic acid are elongated into C5-C8 medium-chain carboxylic acids. Medium-chain carboxylic acids can undergo hydrogenation-dehydration of the medium-chain carboxylic acids into C5-C8 linear olefins. The C5-C8 linear olefins are then oligomerized to a C10-C25 mixture comprising olefins, paraffin, cycloparaffins, and aromatics through dimerization; and saturated to C10-C25 mixture by hydrogenation to produce the biofuel. |
| FILED | Thursday, September 15, 2022 |
| APPL NO | 17/945839 |
| CURRENT CPC | Fuels Not Otherwise Provided for; Natural Gas; Synthetic Natural Gas Obtained by Processes Not Covered by Subclasses C10G, C10K; Liquefied Petroleum Gas; Adding Materials to Fuels or Fires to Reduce Smoke or Undesirable Deposits or to Facilitate Soot Removal; Firelighters C10L 1/02 (20130101) Original (OR) Class C10L 2200/0476 (20130101) C10L 2290/26 (20130101) C10L 2290/544 (20130101) Apparatus for Enzymology or Microbiology; C12M 47/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230096778 | Bae et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rensselaer Polytechnic Institute (Troy, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chulsung Bae (Cohoes, New York); Gregory Kline (Cohoes, New York) |
| ABSTRACT | The present disclosure relates, in part, to polymers having a graft chain and/or a cyclic amino group. In particular examples, the graft chain and/or the cyclic amino group provides enhanced hydrophilicity, alkaline stability, and/or anion solvation. Compounds, compositions, and methods are described herein. |
| FILED | Friday, January 22, 2021 |
| APPL NO | 17/758767 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 277/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230096922 | Parish et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Flowserve Management Company (Irving, Texas) |
| ASSIGNEE(S) | Flowserve Management Company (Irving, Texas) |
| INVENTOR(S) | Paul Jeffrey Parish (Spanish Fork, Utah); Michael P. Nelson (Lehi, Utah) |
| ABSTRACT | A valve configured to control a flow of a process fluid includes a pair of packing seals separated by a seal gap space along a linear valve stem of the valve, and a pressurization port that can be used to apply a pressurizing fluid, such as nitrogen gas, to the seal gap at a gap pressure that is higher than the process fluid pressure, thereby ensuring that any leakage past the packing seals will be of pressurizing fluid into the process fluid and/or into the environment, and that no process fluid will escape into the environment. The pressure or flow rate of the pressurizing fluid can be monitored to detect and quantify any pressurization fluid leakage past either of the packing seals, so that a maintenance action can be applied to the valve, such as re-tightening or replacing at least one of the packing seals, or replacing the valve. |
| FILED | Monday, September 27, 2021 |
| APPL NO | 17/485674 |
| CURRENT CPC | Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 37/0091 (20130101) F16K 41/02 (20130101) F16K 41/003 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230097018 | Costello et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zachary Costello (Berkeley, California); Hector Garcia Martin (Oakland, California) |
| ABSTRACT | Disclosed herein include systems, devices, and methods for kinetic learning, which can include, for example, training and/or using a machine learning model, such as training a machine learning model and using the machine learning model to simulate a virtual strain of an organism or to determine possible modifications of an organism. |
| FILED | Tuesday, September 20, 2022 |
| APPL NO | 17/948911 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) G16B 40/00 (20190201) Original (OR) Class G16B 45/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230097524 | Myllenbeck et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas Myllenbeck (Livermore, California); Ryan Wesley Davis (San Jose, California); Eric Monroe (Melrose, Massachusetts); Joseph Carlson (Castro Valley, California) |
| ABSTRACT | A fuel for an internal combustion engine includes a C5 to C30 dialkoxyalkanoate corresponding to formula (I): wherein the R1 group is —H or a —CH3 group, the R2 and R2′ groups are alkyl groups independently selected to have 1 to 9 carbon atoms; and the R3 group is selected to have 1 to 9 carbon atoms. The compounds described herein may be used as neat fuels or mixed fuels (with diesel, biodiesel, jet fuel, marine fuel or other fuel compounds) in autoignition or spark ignition engines, such as diesel engines, gasoline (spark ignition) engines, MCCI, Homogeneous Charge Compression Ignition (HCCI) engines, or more generally in Low-Temperature Gasoline Combustion (LTGC) engines (using gasoline-like fuels), that have the high-efficiency advantages of HCCI but can operate with some level of charge inhomogeneities. Methods of making these compounds are environmentally friendly and can be done in a continuous manner. |
| FILED | Monday, October 03, 2022 |
| APPL NO | 17/958560 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 67/08 (20130101) Fuels Not Otherwise Provided for; Natural Gas; Synthetic Natural Gas Obtained by Processes Not Covered by Subclasses C10G, C10K; Liquefied Petroleum Gas; Adding Materials to Fuels or Fires to Reduce Smoke or Undesirable Deposits or to Facilitate Soot Removal; Firelighters C10L 1/19 (20130101) Original (OR) Class C10L 10/12 (20130101) C10L 2200/0423 (20130101) C10L 2200/0446 (20130101) C10L 2270/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230097609 | Parish et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Flowserve Management Company (Irving, Texas) |
| ASSIGNEE(S) | Flowserve Management Company (Irving, Texas) |
| INVENTOR(S) | Paul Jeffrey Parish (Spanish Fork, Utah); Michael P. Nelson (Lehi, Utah) |
| ABSTRACT | A valve for controlling a molten liquid includes an expansion port in liquid communication with an internal volume of the valve that is filled with the molten liquid. An expansion valve can be opened during unfreezing of the valve, to allow melting process substance to expand out of the internal volume into an expansion line as it is melted. During initialization of the valve, an inert gas source, pressure regulator, and ultrasonic transition level sensor can be used to establish a liquid/gas interface at a desired height within the expansion line. The valve can include a multi-zone heater, wherein a first of the zones is adjacent the expansion port, so that during unfreezing, after the first zone has been melted, the remaining zones can be sequentially activated in an order that ensures that each zone is activated only after an adjacent zone has been melted. |
| FILED | Monday, September 27, 2021 |
| APPL NO | 17/485676 |
| CURRENT CPC | Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 1/52 (20130101) F16K 49/005 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230098257 | Visco et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PolyPlus Battery Company (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven J. Visco (Berkeley, California); Vitaliy Nimon (San Francisco, California); Yevgeniy S. Nimon (Danville, California); Bruce D. Katz (Moraga, California); Richard L. Swisher (Northfield, Minnesota) |
| ABSTRACT | Methods for making solid-state laminate electrode assemblies include methods of forming a solid electrolyte interphase (SEI) by ion implanting nitrogen and/or phosphorous into the glass surface by ion implantation. |
| FILED | Thursday, August 04, 2022 |
| APPL NO | 17/817494 |
| CURRENT CPC | Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials C03C 17/3626 (20130101) C03C 17/3649 (20130101) C03C 17/3671 (20130101) C03C 2218/151 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/24 (20130101) C23C 14/34 (20130101) C23C 14/48 (20130101) C23C 14/0641 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/382 (20130101) H01M 4/0407 (20130101) H01M 4/0423 (20130101) Original (OR) Class H01M 4/628 (20130101) H01M 4/1395 (20130101) H01M 10/052 (20130101) H01M 10/0562 (20130101) H01M 2300/0068 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230098274 | Carlson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | LG Energy Solution, Ltd. (Seoul, South Korea) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven A. Carlson (Cambridge, Massachusetts); Ifenna Kingsley Anakor (Allston, Massachusetts); Greg Robert Farrell (Sudbury, Massachusetts) |
| ABSTRACT | Provided are separators for use in an electrochemical cell comprising (a) an inorganic oxide and (b) an organic polymer, wherein the inorganic oxide comprises organic substituents. Also provided are electrochemical cells comprising such separators. |
| FILED | Thursday, December 01, 2022 |
| APPL NO | 18/073436 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 14/303 (20130101) C04B 24/00 (20130101) C04B 24/023 (20130101) C04B 26/06 (20130101) C04B 38/0074 (20130101) C04B 2111/00612 (20130101) C04B 2111/00801 (20130101) C04B 2111/00853 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 50/411 (20210101) H01M 50/434 (20210101) H01M 50/443 (20210101) H01M 50/446 (20210101) Original (OR) Class H01M 50/494 (20210101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/10 (20130101) Technical Subjects Covered by Former US Classification Y10T 29/49115 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230098669 | Leguizamon et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Samuel Carlos Leguizamon (Albuquerque, New Mexico); Jeffrey Clayton Foster (Albuquerque, New Mexico); Adam W. Cook (Albuquerque, New Mexico); Leah Appelhans (Tijeras, New Mexico); Erica M. Redline (Albuquerque, New Mexico); Brad Howard Jones (Albuquerque, New Mexico) |
| ABSTRACT | The invention is directed to the selective dual wavelength olefin metathesis polymerization for additive manufacturing. Dual-wavelength stereolithographic printing uses ring-opening metathesis polymerization of the metathesis-active polymers. As an example, a resin formulation based on dicyclopentadiene was produced using a photolatent olefin metathesis catalyst, various photosensitizers and photobase generators to achieve efficient initiation by light at one wavelength (e.g., blue) and fast catalyst decomposition and polymerization deactivation by light at a second wavelength (e.g., ultraviolet). This process enables 2-dimensional stereolithographic printing, either using photomasks or with patterned, collimated light. Importantly, the same process was readily adapted for 3-dimensional continuous additive manufacturing, with printing rates of up to 36 mm h−1 for patterned light and up to 180 mm h−1 using un-patterned, high intensity light. |
| FILED | Wednesday, August 31, 2022 |
| APPL NO | 17/900584 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 136/20 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230098681 | Nash et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California); The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Landon D. Nash (Sunnyvale, California); Duncan J. Maitland (College Station, Texas); Nicole Docherty (Troy, Michigan); Thomas S. Wilson (San Leandro, California); Ward Small, IV (Livermore, California); Jason Ortega (Pacifica, California); Pooja Singhal (Redwood City, California) |
| ABSTRACT | An embodiment includes a system comprising: a monolithic shape memory polymer (SMP) foam having first and second states; wherein the SMP foam includes: (a) polyurethane, (b) an inner half portion having inner reticulated cells defined by inner struts, (c) an outer half portion, having outer reticulated cells defined by outer struts, surrounding the inner portion in a plane that provides a cross-section of the SMP foam, (d) hydroxyl groups chemically bound to outer surfaces of both the inner and outer struts. Other embodiments are discussed herein. |
| FILED | Thursday, September 29, 2022 |
| APPL NO | 17/956236 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 24/0036 (20130101) A61L 24/046 (20130101) A61L 31/06 (20130101) A61L 31/14 (20130101) A61L 31/146 (20130101) Processes for Applying Fluent Materials to Surfaces, in General B05D 1/62 (20130101) B05D 3/144 (20130101) B05D 7/02 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 59/14 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2033/04 (20130101) B29K 2995/0093 (20130101) Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 5/18 (20130101) B32B 27/06 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 9/36 (20130101) C08J 9/365 (20130101) Original (OR) Class C08J 2201/026 (20130101) C08J 2375/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230098711 | Baker et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sarah Baker (Dublin, California); Joshuah K. Stolaroff (Oakland, California); Congwang Ye (Livermore, California) |
| ABSTRACT | Methods of forming such microcapsules, in accordance with some embodiments, include: emulsifying at least one biocatalyst in a polymer precursor mixture; emulsifying the polymer precursor mixture in an aqueous carrier solution; crosslinking one or more polymer precursors of the polymer precursor mixture to form a plurality of microcapsules each independently comprising: a polymeric shell permeable to one or more target gases; and at least one biocatalyst disposed in an interior of the polymeric shell. In further embodiments, corresponding methods of using the inventive microcapsules for catalyzing one or more target gases using include: exposing a plurality of the biocatalytic microcapsules to the one or more target gases. |
| FILED | Tuesday, November 22, 2022 |
| APPL NO | 17/992188 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/003 (20130101) B01J 31/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 11/04 (20130101) C12N 11/082 (20200101) C12N 11/084 (20200101) C12N 11/087 (20200101) C12N 11/089 (20200101) C12N 11/096 (20200101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230099529 | Selvamanickam et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Houston System (Houston, Texas); AMPeers LLC (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Venkat Selvamanickam (Houston, Texas); Soumen Kar (Houston, Texas) |
| ABSTRACT | A round superconductor wire, method for fabricating same, and method for detecting quench in same are disclosed. Embodiments are directed to a round superconductor wire including a superconductor wire former and at least one superconductor tape wound on the superconductor wire former. Each superconductor tape includes: a substrate; a buffer film stack overlying the substrate; and a superconductor film overlying the buffer film stack. These and other embodiments achieve a round superconductor wire having improved engineering current density in high magnetic field applications when made in small diameters. |
| FILED | Wednesday, December 23, 2020 |
| APPL NO | 17/801984 |
| CURRENT CPC | Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 12/06 (20130101) Original (OR) Class H01B 12/08 (20130101) H01B 13/0036 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230099720 | Parish et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Flowserve Management Company (Irving, Texas) |
| ASSIGNEE(S) | Flowserve Management Company (Irving, Texas) |
| INVENTOR(S) | Paul Jeffrey Parish (Spanish Fork, Utah); Michael P. Nelson (Lehi, Utah) |
| ABSTRACT | A valve system for controlling a corrosive process liquid flow, while avoiding corrosion due to a liquid/vapor interface of the process liquid, causes the process liquid to flow from the valve through a purge port into a vertical segment of a purge line. During valve initialization, a non-reactive gas backpressure within the purge line is controlled to establish the liquid/vapor interface at a desired height within the vertical segment, as determined by an interface level sensor, which can be ultrasonic. The vertical segment is constructed from, or lined with, a material that can withstand contact with the liquid/vapor interface. During valve operation, the non-reactive gas pressure can continue to be regulated, or a purge valve can be shut, trapping a fixed quantity of the non-reactive gas within the purge line. The valve can include a heater configured to prevent a molten process liquid from solidifying within the valve. |
| FILED | Monday, September 27, 2021 |
| APPL NO | 17/485666 |
| CURRENT CPC | Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 1/54 (20130101) Original (OR) Class F16K 39/026 (20130101) F16K 2200/402 (20210801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230099785 | ATANASSOV et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Plamen ATANASSOV (Irvine, California); Shengyuan GUO (Irvine, California); Yuanchao LIU (Irvine, California) |
| ABSTRACT | A supported catalyst for reducing CO2 is provided. The supported catalyst includes a plurality of support particles; and a plurality of catalyst particles disposed over each support particle. Characteristically, the catalyst particles has formula PdHx/C wherein x is 0.3 to 0.7. Methods for making the support particles and using the support particles to reduce carbon dioxide are also provided. |
| FILED | Friday, September 30, 2022 |
| APPL NO | 17/957693 |
| CURRENT CPC | Fuels Not Otherwise Provided for; Natural Gas; Synthetic Natural Gas Obtained by Processes Not Covered by Subclasses C10G, C10K; Liquefied Petroleum Gas; Adding Materials to Fuels or Fires to Reduce Smoke or Undesirable Deposits or to Facilitate Soot Removal; Firelighters C10L 1/02 (20130101) Original (OR) Class C10L 2200/0254 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 3/07 (20210101) C25B 3/26 (20210101) C25B 9/19 (20210101) C25B 9/63 (20210101) C25B 11/037 (20210101) C25B 11/065 (20210101) C25B 11/081 (20210101) C25B 13/04 (20130101) C25B 15/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230099939 | KELLERMAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | LEADING EDGE EQUIPMENT TECHNOLOGIES, INC. (Wilmington, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter KELLERMAN (Essex, Massachusetts); Alison GREENLEE (Somerville, Massachusetts); Parthiv DAGGOLU (Danvers, Massachusetts); Alexander MARTINEZ (Woburn, Massachusetts); Nathan STODDARD (Chalfont, Pennsylvania) |
| ABSTRACT | An apparatus for controlling a thickness of a crystalline ribbon grown on a surface of a melt includes a crucible configured to hold a melt; a cold initializer facing an exposed surface of the melt; a segmented cooled thinning controller disposed above the crucible on a side of the crucible with the cold initializer; and a uniform melt-back heater disposed below of the crucible opposite the cooled thinning controller. Heat is applied to the ribbon through the melt using a uniform melt-back heater disposed below the melt. Cooling is applied to the ribbon using a segmented cooled thinning controller facing the crystalline ribbon above the melt. |
| FILED | Friday, February 19, 2021 |
| APPL NO | 17/801181 |
| CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 15/002 (20130101) C30B 15/06 (20130101) C30B 15/14 (20130101) Original (OR) Class C30B 15/22 (20130101) C30B 29/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230099998 | Loeb et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Colin Loeb (Fairfield, California); Patrick Campbell (Oakland, California); Jennifer Marie Knipe (Oakland, California); Michael Stadermann (Pleasanton, California) |
| ABSTRACT | A product includes an aerogel having a single bulk structure, the single bulk structure having at least one dimension greater than 10 millimeters. The single bulk structure includes a plurality of pores, where each pore has a largest diameter defined as a greatest distance between pore walls of the respective pore. In addition, an average of the largest diameters of a majority of the pores is within a specified range, and the plurality of pores are distributed substantially homogenously throughout the single bulk structure. |
| FILED | Wednesday, November 30, 2022 |
| APPL NO | 18/072468 |
| CURRENT CPC | Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2061/04 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/318 (20170801) Original (OR) Class C01B 32/336 (20170801) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 8/22 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 9/36 (20130101) C08J 9/286 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230100234 | Fink et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael J. Fink (Cambridge, Massachusetts); Christoffer Karl Abrahamsson (Cambridge, Massachusetts); George M. Whitesides (Newton, Massachusetts) |
| ABSTRACT | A process for preparing paramagnetic compounds is described. A paramagnetic compound made by the process is described, including its use in density-based analysis by MagLev. |
| FILED | Tuesday, September 06, 2022 |
| APPL NO | 17/903349 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/003 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/0656 (20130101) G01N 2015/0687 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230100328 | Zaidy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aliasger Tayeb Zaidy (Seattle, Washington); David Andrew Roberts (Wellesley, Massachusetts); Patrick Michael Sheridan (Boulder, Colorado); Lukasz Burzawa (Boise, Idaho) |
| ABSTRACT | Disclosed in some examples are improved address prediction and memory preloading that leverages next-delta prediction and/or far-delta prediction for scheduling using a DNN. Previous memory access sequence data that identify one or more memory addresses previously accessed by one or more processors of a system may be processed and then converted into a sequence of delta values. The sequence of delta values are then mapped to one or more classes that are then input to a DNN. The DNN then outputs a predicted future class identifier sequence that represents addresses that the DNN predicts will be accessed by the processor in the future. The predicted future class identifier sequence is then converted back to a predicted delta value sequence and back into a set of one or more predicted addresses. |
| FILED | Monday, July 18, 2022 |
| APPL NO | 17/867371 |
| CURRENT CPC | Electric Digital Data Processing G06F 12/0646 (20130101) G06F 12/0882 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230100910 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Zhengcheng Zhang (Naperville, Illinois); Qian Liu (Darien, Illinois); Krzysztof Pupek (Plainfield, Illinois); Trevor L. Dzwiniel (Carol Stream, Illinois) |
| ABSTRACT | An electrolyte for use in a lithium-ion or sodium-ion battery includes a salt such as a lithium salt, a sodium salt, or a mixture of any two or more thereof; and a solvent that includes a compound represented as Formula I, II, or a mixture of any two or more thereof: wherein: R1 is substituted or unsubstituted alkyl, substituted or unsubstituted haloalkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted polyether; R2 is F, a fluoroalkyl, fluorocycloalkyl; R3 is F, a fluoroalkyl, fluorocycloalkyl; and R4 is substituted or unsubstituted alkyl, substituted or unsubstituted haloalkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, or substituted or unsubstituted polyether; and R5 is a fluoroalkyl or fluorocycloalkyl. |
| FILED | Wednesday, August 25, 2021 |
| APPL NO | 17/411706 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0525 (20130101) H01M 10/0567 (20130101) H01M 10/0568 (20130101) Original (OR) Class H01M 10/0569 (20130101) H01M 2300/0037 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230101258 | Parish et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Flowserve Management Company (Irving, Texas) |
| ASSIGNEE(S) | Flowserve Management Company (Irving, Texas) |
| INVENTOR(S) | Paul Jeffrey Parish (Spanish Fork, Utah); Michael P. Nelson (Lehi, Utah); Ivica Radman (Kaernten, Austria) |
| ABSTRACT | A valve includes at least one valve stem seal, such as a packing seal, that is included in a removable seal cartridge. The valve stem is connected to the actuator via a linkage, which can be removed to provide a linkage gap between the actuator and the valve stem. The seal cartridge can then be slid along the valve stem into the linkage gap and laterally removed from the valve, whereupon the seals within the seal cartridge can be refurbished. The valve can be a rotary or linear valve. In embodiments, the linkage gap can be increased by linear displacement of the actuator away from the valve stem. The seal cartridge can be re-installed in the valve after refurbishment, or a substantially identical replacement seal cartridge can be provided, and can be installed in the valve in replacement of the removed seal cartridge, thereby minimizing downtime of the valve. |
| FILED | Monday, September 27, 2021 |
| APPL NO | 17/485678 |
| CURRENT CPC | Pistons; Cylinders; Sealings F16J 15/008 (20130101) Original (OR) Class F16J 15/189 (20130101) Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 1/36 (20130101) F16K 1/422 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230101310 | Sheridan |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Patrick Michael Sheridan (Boulder, Colorado) |
| ABSTRACT | Disclosed in some examples are methods, systems, memory devices, and machine-readable mediums which store a single compressed value per line with a marker value in a front of the compressed version of the memory line. In some examples, the only value stored in the memory line is the value normally stored therein. This removes the complexity of the prediction tables and the inclusion of invalid values as well as preventing the penalty when those prediction tables are wrong. Furthermore, by inclusion of the marker in the beginning of the memory line, the system can quickly determine the compression status of the memory line without having to read the entire line. That is, it can quickly stop reading the rest of the memory line once the compressed data is read out which saves the memory device from having to read the entire line. |
| FILED | Thursday, July 14, 2022 |
| APPL NO | 17/865102 |
| CURRENT CPC | Static Stores G11C 7/109 (20130101) G11C 7/1069 (20130101) G11C 7/1096 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230101595 | Sabharwall et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Paul Marotta (Jersey, New Jersey); Battelle Energy Alliance, LLC (Idaho Falls, Idaho); University of Idaho (Moscow, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Piyush Sabharwall (Idaho Falls, Idaho); Richard Christensen (Idaho Falls, Idaho); Paul Marotta (Jersey City, New Jersey); Kristen Geddes (Idaho Falls, Idaho); Alberto Cardenas-Melgar (Rexburg, Idaho); Robin Roper (Idaho Falls, Idaho) |
| ABSTRACT | A fluid flow simulation device may include a heating chamber configured to heat a conductive fluid with one or more electrodes. The fluid flow simulation device may also include a heat exchanger positioned over the heating chamber and a downcomer coupled between an outlet of the heat exchanger and a bottom of the heating chamber. |
| FILED | Tuesday, September 27, 2022 |
| APPL NO | 17/935861 |
| CURRENT CPC | Measuring Not Specially Adapted for a Specific Variable; Arrangements for Measuring Two or More Variables Not Covered in a Single Other Subclass; Tariff Metering Apparatus; Measuring or Testing Not Otherwise Provided for G01D 11/24 (20130101) Original (OR) Class Measuring Volume, Volume Flow, Mass Flow or Liquid Level; Metering by Volume G01F 3/38 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230101742 | Rieger et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| INVENTOR(S) | Craig G. Rieger (Pocatello, Idaho); Edward E. Springer (Idaho Falls, Idaho); Michael V. McCarty (Idaho Falls, Idaho); Timothy R. McJunkin (Idaho Falls, Idaho) |
| ABSTRACT | A component security device may be disposed at an interface between a component and a cyber-physical system. The disclosed component security device may be physically and/or electrically coupled between the component and infrastructure of the cyber-physical system, such as a backplane, bus, and/or the like. The component security device may be configured to monitor the component, and selectively isolate the component from the cyber-physical system. Since the component security device is interposed at the interface of the component, the component security device may be capable of isolating the component regardless of whether the component has been compromised (e.g., regardless of whether the component is capable of complying with system commands). |
| FILED | Monday, December 05, 2022 |
| APPL NO | 18/061901 |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/4183 (20130101) Original (OR) Class G05B 19/4184 (20130101) G05B 19/4185 (20130101) Electric Digital Data Processing G06F 21/82 (20130101) G06F 21/85 (20130101) G06F 21/554 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230101816 | Lepro Chavez et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| INVENTOR(S) | Xavier N. Lepro Chavez (Dublin, California); Chantel M. Aracne-Ruddle (Livermore, California); Leonardus Bimo Bayu Aji (Livermore, California); Sergei O. Kucheyev (Oakland, California); Michael Stadermann (Pleasanton, California) |
| ABSTRACT | Disclosed here is a method of fabricating a covalently reinforced carbon nanotube (CNT) assembly. The method includes producing a CNT assembly by pulling entangled CNTs from a CNT array fabricated on a substrate, the CNT assembly including a plurality of CNTs that are aligned; and creating covalent bonding between the CNTs of the CNT assembly by applying a high energy ion irradiation to the CNT assembly. |
| FILED | Monday, June 20, 2022 |
| APPL NO | 17/844492 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/084 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/16 (20170801) C01B 32/164 (20170801) C01B 32/168 (20170801) Original (OR) Class C01B 2202/08 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/847 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230101997 | Kaburlasos et al. |
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| FUNDED BY |
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| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nikos Kaburlasos (Folsom, California); Rodrigo De Oliveira Vivi (Lithia, Florida); Phani Kumar Kandula (Murugeshpalya, India); Marc Beuchat (Folsom, California); Mark J. Luckeroth (Portland, Oregon); Eric J.M. Moret (Beaverton, Oregon); David N. Lombard (Rossmoor, California); John Kelbert (Aptos, California); Brad Bittel (Beaverton, Oregon) |
| ABSTRACT | Disclosed herein are embodiments of systems and methods for stable and elevated idle-mode temperature for assembled semiconductor devices. In an embodiment, a processor includes a communication interface configured to receive, from a first hardware component, instructions assigned to the processor for execution. The processor also includes temperature-measurement circuitry configured to monitor an on-chip temperature of the processor. The processor also includes control logic configured to: determine whether the processor is active or idle; determine whether the on-chip temperature of the processor exceeds a first threshold; based on determining that the processor is idle and that the on-chip temperature of the processor exceeds the first threshold, disable one or more idle-mode power-saving features of the processor; and selectively adjust one or more operating parameters of the processor to keep the on-chip temperature of the processor between the first threshold and a second (higher) threshold. |
| FILED | Thursday, September 30, 2021 |
| APPL NO | 17/490290 |
| CURRENT CPC | Electric Digital Data Processing G06F 1/08 (20130101) G06F 1/3228 (20130101) G06F 1/3296 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230102034 | White et al. |
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| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregory K. White (Livermore, California); Steven A. Kreek (Livermore, California) |
| ABSTRACT | An incident exercise system supports an incident exercise. The incident exercise system accesses an exercise plan defining an incident within a theater of operation. The incident exercise system administers the incident exercise by generating detector signals factoring in incident effects and characteristic effects of the theater of operation. The incident exercise system sends detector signals to detectors that filter effect of background noise from the detector signals to generate filtered detector signals and output data derived from the filtered detector signals. The incident exercise system supports dynamically modifying the exercise plan during the incident exercise. |
| FILED | Wednesday, September 29, 2021 |
| APPL NO | 17/489752 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 50/26 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230102140 | ZHANG et al. |
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| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Yuepeng ZHANG (Naperville, Illinois); Sanja TEPAVCEVIC (Chicago, Illinois); Devon J. POWERS (Lemont, Illinois); Peter ZAPOL (Hinsdale, Illinois); John N. HRYN (Hawthorn Woods, Illinois); Gregory K. KRUMDICK (Homer Glen, Illinois); Ozgenur KAHVECLOGLU (Naperville, Illinois); Krzystof Z. PUPEK (Plainfield, Illinois); Michael John COUNIHAN (Downers Grove, Illinois) |
| ABSTRACT | A solid-state electrolyte for a multilayer solid-state electrochemical cell is described herein. The electrolyte comprises a lithium electrolyte salt and nanofibers of a cubic phase lithium lanthanum zirconium oxide (c-LLZO), and a polymer interspersed with the nanofibers and electrolyte salt. Electrochemical cells comprising the solid-state electrolyte, and solid-state cathodes comprising the nanofibers of c-LLZO are also described herein. |
| FILED | Thursday, September 30, 2021 |
| APPL NO | 17/490956 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/056 (20130101) Original (OR) Class H01M 2004/028 (20130101) H01M 2300/0077 (20130101) H01M 2300/0082 (20130101) H01M 2300/0091 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230102474 | Gailus |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Nanocomp Technologies, Inc. (The Woodlands, Texas) |
| ASSIGNEE(S) | Nanocomp Technologies, Inc. (The Woodlands, Texas) |
| INVENTOR(S) | David Gailus (Merrick, New Hampshire) |
| ABSTRACT | The present disclosure provides a method for purifying nanostructured material comprising carbon nanotubes, metal impurities and amorphous carbon impurities. The method generally includes oxidizing the unpurified nanostructured material to remove the amorphous carbon and thereby exposing the metal impurities and subsequently contacting the nanostructured material with carbon monoxide to volatilize the metal impurities and thereby substantially remove them from the nanostructured material. |
| FILED | Tuesday, February 23, 2021 |
| APPL NO | 17/801286 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/20 (20130101) B01J 2231/005 (20130101) B01J 2531/842 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/17 (20170801) Original (OR) Class C01B 32/159 (20170801) C01B 32/162 (20170801) C01B 2202/02 (20130101) C01B 2202/06 (20130101) C01B 2202/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230102656 | Sanders et al. |
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| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian Sanders (Knoxville, Tennessee); Stephanie S. Galanie (Scotch Plains, New Jersey); Jerry M. Parks (Knoxville, Tennessee) |
| ABSTRACT | A compound having the following structure: wherein: R1 is a linker having the formula —(CH2)n-L1-, wherein L1 contains 1-6 carbon atoms and at least one —NH— linkage and at least one oxygen-containing or sulfur-containing linkage, and n is an integer of 0-3; R2 is a group having the formula —C(Y)-E, wherein Y is O or S, and E is a hydrocarbon group and either: (i) at least one carbon-carbon or carbon-nitrogen unsaturated bond or (ii) at least one alkyl halide group; R3 is selected from H, NR′2, NHC(O)R′, and —(CH2)p-T, wherein T contains at least one —NH— linkage; Ra, Rb, Rc, Rd, Re, and Rf are independently selected from of H, hydrocarbon groups containing 1-3 carbon atoms, fluorine atom, and chlorine atom; X is N or CR9, wherein R9 is selected from H, hydrocarbon groups containing 1-3 carbon atoms, fluorine atom, and chlorine atom; and pharmaceutically acceptable salts thereof. |
| FILED | Friday, August 26, 2022 |
| APPL NO | 17/896182 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Acyclic or Carbocyclic Compounds C07C 243/28 (20130101) Original (OR) Class C07C 255/03 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20230094133 | FORREST et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | Regents of the University of Michigan (Ann Arbor, Michigan) |
| INVENTOR(S) | Stephen R. FORREST (Ann Arbor, Michigan); Yue QU (Ann Arbor, Michigan) |
| ABSTRACT | A number of new solutions for enhancing the extraction of waveguided mode and suppressing surface plasmon polariton mode in OLEDs are disclosed. For example, an OLED is disclosed that includes: a substrate having a first side and a second side; a reflective layer disposed over the first side of the substrate; a grid layer consisting of two optically transparent materials with different refractive indices disposed on the reflective layer; a transparent first electrode provided over the grid layer; an organic emissive layer provided over the transparent first electrode; and a transparent second electrode provided over the organic emissive layer, where the grid layer scatters trapped waveguided modes from the organic emissive layer. |
| FILED | Thursday, November 17, 2022 |
| APPL NO | 18/056414 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/504 (20130101) H01L 51/5072 (20130101) H01L 51/5212 (20130101) H01L 51/5265 (20130101) H01L 51/5268 (20130101) Original (OR) Class H01L 51/5271 (20130101) H01L 51/5275 (20130101) H01L 2251/558 (20130101) H01L 2251/5369 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230094190 | Autrey et al. |
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| FUNDED BY |
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| APPLICANT(S) | FAYETTEVILLE STATE UNIVERSITY (Fayetteville, North Carolina) |
| ASSIGNEE(S) | FAYETTEVILLE STATE UNIVERSITY (Fayetteville, North Carolina) |
| INVENTOR(S) | Daniel E. Autrey (Fayetteville, North Carolina); Bhoj Gautam (Fayetteville, North Carolina); Shubo Han (Fayetteville, North Carolina) |
| ABSTRACT | A method of synthesizing a MXene material is provided. A starting MAX phase material can be selected, a reaction time and/or reaction temperature can be determined, and subsequently a MXene material can be generated through etching the MAX phase material in an etching solution based on at least one of the determined reaction time and/or reaction temperature. In some instances, the etching solution is an LiF/HCl solution. |
| FILED | Monday, September 27, 2021 |
| APPL NO | 17/486388 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/907 (20170801) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/72 (20130101) C01P 2004/03 (20130101) C01P 2004/04 (20130101) C01P 2006/40 (20130101) C01P 2006/42 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230094580 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wayne State University (Detroit, Michigan) |
| ASSIGNEE(S) | Wayne State University (Detroit, Michigan) |
| INVENTOR(S) | Haipeng Liu (Troy, Michigan); Chunsong Yu (Detroit, Michigan) |
| ABSTRACT | Amphiphilic oligonucleotide conjugates that enhance adjuvant function are disclosed. The conjugates typically include: a lipophilic component, and conjugated thereto (directly or indirectly) an immunomodulating oligonucleotide that, if it were not conjugated to the lipophilic component, would suppress TLR7 and/or TLR8 stimulation. In the presence of albumin, these conjugates significantly enhance adjuvant function, in particular the function of TLR7/8-mediated adjuvants such as an imidazoquinolinamine. The conjugates can be administered, along with an adjuvant compound, to a subject in order to cause and/or enhance an immune response (for instance, to an infectious agent or a cancer antigen) in the subject. |
| FILED | Tuesday, September 06, 2022 |
| APPL NO | 17/930042 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) Original (OR) Class A61K 47/543 (20170801) A61K 47/549 (20170801) A61K 47/554 (20170801) A61K 2039/55511 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/117 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230095339 | Cleland-Huang et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Notre Dame du Lac (South Bend, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jane Cleland-Huang (South Bend, Indiana); Ankit Agrawal (South Bend, Indiana) |
| ABSTRACT | A method for sharing a point-of-interest across a plurality of video feeds from a plurality of optical imaging devices includes receiving an indication of the point-of-interest associated with a first video feed of the plurality of video feeds, the first video feed provided by a first optical imaging device of the plurality of optical imaging devices; determining a geo-location of an object associated with the point-of-interest; determining a position of a second optical imaging device relative to the determined geo-location of the point-of-interest; and overlaying the point-of-interest on a second video feed, the second video feed provided by the second optical imaging device. |
| FILED | Thursday, September 29, 2022 |
| APPL NO | 17/936648 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 39/024 (20130101) B64C 2201/126 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/0038 (20130101) G05D 1/104 (20130101) Electric Digital Data Processing G06F 3/0488 (20130101) Image Data Processing or Generation, in General G06T 15/06 (20130101) G06T 19/006 (20130101) Original (OR) Class G06T 2219/024 (20130101) Image or Video Recognition or Understanding G06V 20/17 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230095547 | VARE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Health Research, Inc. (Menands, New York); The Research Foundation for the State University of New York (Albany, New York); Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ville VARE (Albany, New York); Kathleen McDONOUGH (Menands, New York); Ryan SCHNEIDER (Albany, New York); Paul AGRIS (Durham, North Carolina); Thorsten SEYLER (Durham, North Carolina) |
| ABSTRACT | Provided is a method for inhibiting the growth of Gram-positive bacteria, including contacting said bacteria with a first compound and a second compound, wherein the first compound is a compound of Formula I: and the second compound is an antibiotic other than a compound of Formula I. Also provided is a composition including the first compound and the second compound. |
| FILED | Thursday, August 12, 2021 |
| APPL NO | 17/400336 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 43/78 (20130101) A01N 43/90 (20130101) Biocidal, Pest Repellant, Pest Attractant or Plant Growth Regulatory Activity of Chemical Compounds or Preparations A01P 1/00 (20210801) Preparations for Medical, Dental, or Toilet Purposes A61K 8/49 (20130101) A61K 8/494 (20130101) A61K 31/426 (20130101) Original (OR) Class A61K 31/496 (20130101) A61K 31/7036 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Specific Use of Cosmetics or Similar Toilet Preparations A61Q 17/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230095675 | Sreenivasan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sidlgata V. Sreenivasan (Austin, Texas); Brent Snyder (Austin, Texas); Shrawan Singhal (Austin, Texas) |
| ABSTRACT | A method, computer program product and system for precision inkjet printing. A control variable vector of actuation parameters associated with an inkjet waveform is determined. A printhead is then actuated to eject a grid of droplets from an inkjet onto a substrate based on the inkjet waveform. An image of the grid of droplets on the substrate is acquired. The acquired image is then processed to calculate a fitness function of the inkjet waveform that includes a function of sensed output variables associated with printing characteristics. The control variable vector is then adjusted by updating its topology based on the fitness function to obtain an optimized control variable vector associated with an optimized inkjet waveform. |
| FILED | Thursday, March 25, 2021 |
| APPL NO | 17/913562 |
| CURRENT CPC | Typewriters; Selective Printing Mechanisms,, i.e Mechanisms Printing Otherwise Than From a Forme; Correction of Typographical Errors B41J 2/04516 (20130101) B41J 2/04588 (20130101) Original (OR) Class Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 13/021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230095861 | Sailor et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael J. Sailor (La Jolla, California); Byungji Kim (Cambridge, Massachusetts); Jinyoung Kang (La Jolla, California) |
| ABSTRACT | The disclosure describes a fusogenic liposome-coated porous silicon nanoparticles for high loading efficiency of anionic payloads (small molecules, dyes, nucleic acids), and for non-endocytic delivery of hydrophilic and lipophilic payloads by membrane fusion. The liposome coating can be further modified with targeting peptides or antibodies via covalent binding chemistry between the ligands and functionalized poly(ethylene glycol). The surface moieties can be transferred to the cellular membrane surface by fusogenic uptake. The composition of the disclosure can be applied in the treatment of diseases by delivering entrapped/encapsulated payloads. |
| FILED | Friday, July 22, 2022 |
| APPL NO | 17/871768 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 9/0051 (20130101) A61K 9/1271 (20130101) A61K 9/1272 (20130101) Original (OR) Class A61K 9/5115 (20130101) A61K 31/713 (20130101) A61K 47/64 (20170801) A61K 47/6923 (20170801) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) B82Y 30/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230096500 | Szostak et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michal Szostak (Newark, New Jersey); Qun Zhao (Newark, New Jersey); Guangrong Meng (Newark, New Jersey); Guangchen Li (Newark, New Jersey) |
| ABSTRACT | Provided herein, in part, is a new class of sterically bulky, easily prepared N-heterocyclic carbene (NHC) ligands of Formula I, or a salt, solvate, geometric isomer, or stereoisomer thereof. The ligands are readily synthetically accessible exploiting the cost-effective, modular alkylation of anilines. The NHC ligands of the present disclosure can be used to prepare effective catalysts with transition metals, including the compound of Formula II, or a salt, solvate, geometric isomer, or stereoisomer thereof. In certain embodiments, the transition metal is Pd. |
| FILED | Friday, January 08, 2021 |
| APPL NO | 17/791673 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/181 (20130101) B01J 31/2273 (20130101) Original (OR) Class B01J 31/2278 (20130101) B01J 31/2295 (20130101) B01J 31/2404 (20130101) B01J 2231/42 (20130101) B01J 2531/18 (20130101) B01J 2531/822 (20130101) B01J 2531/824 (20130101) Heterocyclic Compounds C07D 233/62 (20130101) C07D 235/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230096942 | Veige et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam S. Veige (Gainesville, Florida); Stella Almeida Gonsales (Gainesville, Florida); Zhihui Miao (Gainesville, Florida); Brent S. Sumerlin (Gainesville, Florida) |
| ABSTRACT | Provided herein are trans-cyclic polyacetylenes and methods of preparing the trans-cyclic polyacetylenes. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/797770 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 238/02 (20130101) Original (OR) Class C08F 293/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230097272 | CHO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | TAE H. CHO (Ann Arbor, Michigan); ELLIS HERMAN (Cambridge, Massachusetts); ORLANDO TREJO (Ann Arbor, Michigan); MATTISON ROSE (Ann Arbor, Michigan); LAUREN RANSOHOFF (Brookline, Massachusetts); NEIL DASGUPTA (Ann Arbor, Michigan); KIRA BARTON (Ann Arbor, Michigan); HYUNWOO PARK (San Diego, California); ANDRE BROOKS (Southgate, Michigan) |
| ABSTRACT | A spatial atomic layer deposition apparatus that includes a depositor head having an active surface configured to discharge a flow of a first precursor gas, a flow of a second precursor gas, and a flow of an inert gas that separates the flow of the first precursor gas and the flow of the second precursor gas, a substrate plate that opposes the depositor head and has a support surface for retaining a build substrate, a plurality of gap detection sensors producing an output signal indicative of a distance between the active surface of the depositor head and the support surface of the substrate plate, and a controller that communicates with the plurality of gap detection sensors. The gap detection sensors permit a spatial orientation of the active surface of the depositor head and the support surface of the substrate plate to be determined in real-time and monitored. |
| FILED | Saturday, January 23, 2021 |
| APPL NO | 17/801972 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/52 (20130101) C23C 16/4585 (20130101) C23C 16/45519 (20130101) C23C 16/45551 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230098149 | Chilkoti et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ashutosh Chilkoti (Durham, North Carolina); Jacob Heggestad (Durham, North Carolina); David Kinnamon (Durham, North Carolina); Angus Hucknall (Durham, North Carolina) |
| ABSTRACT | Disclosed herein are devices that can be used to detect neutralizing antibodies against multiple pathogens in a quick and accurate manner. An example device includes a substrate; a non-fouling layer; a plurality of pathogen regions, each pathogen region including a different pathogen; and at least one detection region, the detection region including a detection agent that is capable of specifically binding each pathogen and an excipient. In addition, an example method includes contacting a biological sample with a device, and detecting the presence of a neutralizing antibody in the biological sample for each pathogen, wherein the presence of the neutralizing antibody is detected by inhibiting the binding of the detection agent to each pathogen. |
| FILED | Friday, September 30, 2022 |
| APPL NO | 17/957373 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 33/56983 (20130101) Original (OR) Class G01N 2021/6439 (20130101) G01N 2333/165 (20130101) G01N 2469/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230098480 | Che et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Oregon State University (Corvallis, Oregon) |
| ASSIGNEE(S) | Oregon State University (Corvallis, Oregon) |
| INVENTOR(S) | Erzhuo Che (Corvallis, Oregon); Michael Olsen (Corvallis, Oregon) |
| ABSTRACT | A computer implemented scheme for a light detection and ranging (LIDAR) system where point cloud feature extraction and segmentation by efficiently is achieved by: (1) data structuring; (2) edge detection; and (3) region growing. |
| FILED | Wednesday, November 16, 2022 |
| APPL NO | 18/056247 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/4804 (20130101) G01S 17/89 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/13 (20170101) G06T 7/136 (20170101) G06T 7/174 (20170101) G06T 7/187 (20170101) G06T 2207/10028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230098646 | Langer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Robert S. Langer (Newton, Massachusetts); Polina Anikeeva (Lexington, Massachusetts); Carlo Giovanni Traverso (Newton, Massachusetts); Shriya Srinivasan (Cambridge, Massachusetts); Marc-Joseph Antonini (Boston, Massachusetts) |
| ABSTRACT | Articles and systems configured for treating GI motility disorders are generally provided. In some embodiments, an article comprising one or more electrodes (with both sensing and stimulating capabilities) may be configured to stimulate one or more tissues in the GI tract, electrically and/or chemically, to modulate peristalsis and/or allow neuromodulation. In some embodiments, a system comprises a controller that allows for close-loop operation of the article, e.g., such that the article may stimulate (e.g., via a feedback loop) the one or more organs in the GI tract upon receiving sensed parameters in the GI tract. In some embodiments, an implantation tool comprising a sensor may allow for submucosal or intramuscular implantation of an article. The implantation tool and the article may be useful for, for example, as a general platform for delivery of treating GI motility disorders and/or neuromodulation of the GI tract. |
| FILED | Thursday, September 29, 2022 |
| APPL NO | 17/956032 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0538 (20130101) A61B 5/6851 (20130101) A61B 17/3421 (20130101) A61B 17/3468 (20130101) A61B 2017/00867 (20130101) A61B 2017/3454 (20130101) A61B 2560/063 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 31/10 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0509 (20130101) A61N 1/36007 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230098674 | Alsberg et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio); Worcester Polytechnic Institute (Worcester, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eben Alsberg (Cleveland, Ohio); Anna D. Dikina (Mentor, Ohio); Marsha W. Rolle (Worcester, Massachusetts); Hannah A. Strobel (Marlborough, Massachusetts) |
| ABSTRACT | A modular engineered tissue construct includes a plurality of fused self-assembled, scaffold-free, high-density cell aggregates. At least one cell aggregate includes a plurality of cells and a plurality of biocompatible and biodegradable nanoparticles and/or microparticles that are incorporated within the cell aggregates. The nanoparticles and/or microparticles acting as a bulking agent within the cell aggregate to increase the cell aggregate size and/or thickness and improve the mechanical properties of the cell aggregate as well as to deliver bioactive agents. |
| FILED | Tuesday, March 15, 2022 |
| APPL NO | 17/695215 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) A61K 35/32 (20130101) A61K 35/42 (20130101) A61K 35/44 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/54 (20130101) A61L 27/58 (20130101) A61L 27/3804 (20130101) A61L 27/3817 (20130101) Original (OR) Class A61L 27/3839 (20130101) A61L 27/3886 (20130101) Apparatus for Enzymology or Microbiology; C12M 25/14 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0655 (20130101) C12N 5/0697 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230098991 | Nieh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jason Nieh (New York, New York); Alexander Edward Van't Hof, III (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason Nieh (New York, New York); Alexander Edward Van't Hof, III (New York, New York) |
| ABSTRACT | Mechanisms for protecting an application from an untrusted operating system (OS) are provided, the methods including: determining that a virtual address for a page of memory allocated by the untrusted OS for the application belongs to a valid mapping; determining that the page of memory is not already in use; and in response to determining that the virtual address for the page of memory belongs to a valid mapping and determining that the page of memory is not already in use, mapping the page of memory to an enclaved container for the application. Some mechanisms further include unmapping the page of memory from the untrusted OS. In some mechanism, determining that the virtual address for the page of memory belongs to a valid mapping is based on a list of valid mappings for the application. |
| FILED | Thursday, May 19, 2022 |
| APPL NO | 17/749115 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/6281 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230099030 | Koenig et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gary M. Koenig (Charlottesville, Virginia); Geoffrey M. Geise (Charlottesville, Virginia); Patrick M. McCormack (Charlottesville, Virginia) |
| ABSTRACT | An ion conducting polymer comprising a modified poly(phenylene oxide) is described. In an exemplary modified polymer, a portion of the monomeric units are attached to a sulfonate-substituted arylamino moiety, such as a monovalent derivative of phenoxy aniline trisulfonate (BOATS), to form a monomeric unit with a charged side chain. Ion conducting polymers can also be prepared with polyether-containing side chains. The ion conducting polymer can be used to prepare ion exchange membranes which can be used in a variety of applications, such as in non-aqueous redox flow batteries and related energy storage systems. |
| FILED | Friday, March 19, 2021 |
| APPL NO | 17/907773 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 41/13 (20170101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 65/485 (20130101) Compositions of Macromolecular Compounds C08L 71/126 (20130101) Original (OR) Class Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 13/08 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/103 (20130101) H01M 8/188 (20130101) H01M 8/04186 (20130101) H01M 8/04201 (20130101) H01M 50/423 (20210101) H01M 2004/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230099672 | Glick et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Altrix Medical, Inc. (Centreville, Virginia); Defibtech, LLC (Guilford, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gene Glick (Stratford, Connecticut); Daniel Fleck (Potomac, Maryland); David Hicks (Mystic, Connecticut); Michael Hicks (Madison, Connecticut); Matthew Shaker (Centreville, Virginia) |
| ABSTRACT | A charging circuit for a capacitor in a defibrillator includes a control enabling a setting of a desired time to charge a capacitor to a desired voltage in the defibrillator. The charging circuit further includes a flyback charge-pump circuit comprising a switch, an energy transfer transformer, an energy storage capacitor and a control. The switch is configured to stop or allow storage of energy in a transformer. The transformer transfers the energy to the capacitor. The flyback charge-pump circuit controls a duty-cycle on the switch so that a current draw from a power source (e.g. battery) is sufficient to enable charging the capacitor to the desired voltage within the desired time set on the control. |
| FILED | Friday, September 24, 2021 |
| APPL NO | 17/484528 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/3904 (20170801) A61N 1/3912 (20130101) A61N 1/3981 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230099747 | Gómez-Diaz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Juan Sebastián Gómez-Diaz (Davis, California); Alejandro Álvarez-Melcón (Cartagena (Murcia), Spain); Jiawei Zang (Beijing, China PRC) |
| ABSTRACT | A nonreciprocal phased-array antenna includes an array of resonant antennas a1, . . . , an. During transmission, an outbound signal having a frequency f0 and a phase shift φdi caused by propagation through a data network feeds into each resonant antenna ai. Each resonant antenna ai upconverts the outbound signal using a modulation signal having a frequency fm and a phase shift φmi caused by propagation through a modulation network to produce an upconverted radiated signal having a frequency f0+fm and a phase proportionate to φdi+φmi. During reception, an inbound signal of frequency f0+fm is received at each resonant antenna ai and is downconverted using the modulation signal to produce a downconverted signal having a frequency f0 and a phase proportionate to −φmi. After passing through the data network to the inbound port, the downconverted signal has a phase proportionate to φdi−φmi. |
| FILED | Wednesday, November 23, 2022 |
| APPL NO | 17/993249 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 3/36 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230100241 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaoxin Wang (Hanover, New Hampshire); Charlie J. Carver, JR. (Hanover, New Hampshire); Eric R. Fossum (Hanover, New Hampshire); Jifeng Liu (Hanover, New Hampshire); Xia Zhou (Hanover, New Hampshire); Nicholas R. Shade (Hanover, New Hampshire) |
| ABSTRACT | A speckle-suppressing lighting system includes an optical waveguide, a first solid-state light source, a second solid-state light source, and a diffuser. The optical waveguide has a proximal end and a distal end. At least part of the diffuser is between the proximal end and the distal end. The first solid-state light source is optically coupled to the optical waveguide near the proximal end, and emits a first light beam that propagates toward the distal end and has a first center wavelength. The second solid-state light source is optically coupled to the optical waveguide near the proximal end, and emits a second light beam that propagates toward the distal end and has a second center wavelength differing from the first center wavelength. The diffuser diffuses the first light beam and the second light beam. |
| FILED | Monday, September 26, 2022 |
| APPL NO | 17/953129 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/0006 (20130101) G02B 6/0008 (20130101) G02B 27/48 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230100371 | Zelik et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee); Herowear LLC (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karl Zelik (Nashville, Tennessee); Matthew Yandell (Nashville, Tennessee); Matthew Marino (Nashville, Tennessee); Mark Harris (Nashville, Tennessee); Rebeccah Pailes-Friedman (Nashville, Tennessee); Ryu Tomita (Nashville, Tennessee); Paul Reamey (Nashville, Tennessee); Evan Huggins (Nashville, Tennessee) |
| ABSTRACT | A wearable assistance device, such as an exosuit/exoskeleton, for providing assistance (e.g., assistive force or assistive torque) while reducing lower back muscle stress, fatigue, injury risk and/or pain is disclosed. The wearable assistance device includes adjustable modular straps and/or elastic bands. The modular straps allow swapping of different straps to achieve a custom fit of the wearable assistance device. The modular elastic bands allow swapping of different elastic bands to achieve a preferred level of assistance by the wearable assistance device. |
| FILED | Tuesday, March 16, 2021 |
| APPL NO | 17/798169 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 5/022 (20130101) Original (OR) Class A61F 5/0109 (20130101) A61F 2005/0155 (20130101) A61F 2005/0197 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230100399 | Heremans et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph P. Heremans (Upper Arlington, Ohio); Brandi Wooten (Columbus, Ohio) |
| ABSTRACT | Electrically controlled solid-state thermal switches and methods of controlling heat flow. An electrostrictive material is electromagnetically coupled to first and second electrodes that provide an electric field to the electrostrictive material. Different portions of the electrostrictive material are thermally coupled to each of a heat sink and a thermal load so that heat flowing from one into the other passes through the electrostrictive material. A control voltage is applied to the electrodes to selectively generate the electric field, thereby selectively altering the thermal conductivity of the electrostrictive material. The heat sink and thermal load are thereby selectively thermally coupled to each other in dependance on the control voltage. |
| FILED | Wednesday, September 14, 2022 |
| APPL NO | 17/932087 |
| CURRENT CPC | Electric Switches; Relays; Selectors; Emergency Protective Devices H01H 57/00 (20130101) Original (OR) Class H01H 61/01 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230100472 | Sartor et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado); Colorado State University Research Foundation (Fort Collins, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven Sartor (Boulder, Colorado); Niels Damrauer (Boulder, Colorado); Garet Miyake (Fort Collins, Colorado); Cameron Chrisman (Fort Collins, Colorado); Ryan Pearson (Berkeley, California) |
| ABSTRACT | Phenothiazine compounds of Formula (I) are described herein. These compounds are useful as highly reducing organic photoredox catalysts. Suitable substrates for use with the compounds of Formula (I) include acrylates, styrene, acrylamides, acrylonitrile, vinyl chloride, methylacrylonitrile, vinyl acetate, and acrylic acid. |
| FILED | Friday, January 08, 2021 |
| APPL NO | 17/789874 |
| CURRENT CPC | Heterocyclic Compounds C07D 279/24 (20130101) C07D 279/30 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230101350 | Leamy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael J. Leamy (Atlanta, Georgia); Amir A. Darabi (Atlanta, Georgia); Emily Kliewer (Atlanta, Georgia) |
| ABSTRACT | An exemplary embodiment of the present disclosure provides a multiplexer/demultiplexer, comprising a plurality of unit cells arranged in a lattice, a first domain, a second domain, a third domain, and a controller. Each of the unit cells can comprise a topological-insulative material, a first piezoelectric patch, and a second piezoelectric patch. A first domain can comprise a first portion of the plurality of unit cells. A second domain can comprise a second portion of the plurality of unit cells. A third domain can comprise a third portion of the plurality of unit cells. The controller can be configured to: apply a negative capacitance to the first piezoelectric patches in the first domain; apply a negative capacitance to the second piezoelectric patches in the second domain; and alternately apply a negative capacitance to the first and second piezoelectric patches, respectively, in the third domain. |
| FILED | Tuesday, September 27, 2022 |
| APPL NO | 17/935694 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 41/042 (20130101) Impedance Networks, e.g Resonant Circuits; Resonators H03H 9/72 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230102379 | ROPER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | M. Caroline ROPER (Riverside, California); Philippe ROLSHAUSEN (Riverside, California); Jonathan LOCKNER (San Diego, California); Katherine MALONEY (San Diego, California); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Califomia, California); POINT LOMA NAZARENE UNIVERSITY (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | M. Caroline ROPER (Riverside, California); Philippe ROLSHAUSEN (Riverside, California); Jonathan LOCKNER (San Diego, California); Katherine MALONEY (San Diego, California) |
| ABSTRACT | Certain embodiments of the invention provide a method of inhibiting Candidatus Liberibacter asiaticus (CLas) growth and/or treating a CLas infection (e.g., Huanglongbing) in a plant, comprising introducing to the plant at least one compound selected from the group consisting of: a cladosporol compound, a radicinin compound (e.g., a compound of formula (I)), and an epicoccamide compound, or a salt thereof. This present invention also provides methods of screening or identifying CLas inhibitory compounds. |
| FILED | Friday, January 22, 2021 |
| APPL NO | 17/794527 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 35/06 (20130101) A01N 43/20 (20130101) A01N 43/36 (20130101) A01N 43/90 (20130101) Original (OR) Class Biocidal, Pest Repellant, Pest Attractant or Plant Growth Regulatory Activity of Chemical Compounds or Preparations A01P 1/00 (20210801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20230094112 | RAJASHEKARA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gireesh RAJASHEKARA (Wooster, Ohio); Loic DEBLAIS (Wooster, Ohio); Yosra A. HELMY (Wooster, Ohio); Dipak KATHAYAT (Wooster, Ohio); Sally A. MILLER (Wooster, Ohio) |
| ABSTRACT | Disclosed herein are methods of treating a subject with a bacterial infection preventing a bacterial infection, comprising administering to the subject an effective amount of at least one compound, of a derivative thereof, having the formula of SM1, SM3, SM4 or SM5. Also described are methods of inhibiting bacterial growth in a plant comprising contacting the plant with an effective amount of at least one compound, or a derivative thereof, testing the formula of SM1, SM3, SM4, or SM5. The methods are effective against the area of bacterial pathogens in various animals and plants. |
| FILED | Friday, October 07, 2022 |
| APPL NO | 17/938872 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 43/50 (20130101) A01N 43/52 (20130101) A01N 47/44 (20130101) Fodder A23K 20/111 (20160501) A23K 20/137 (20160501) A23K 20/195 (20160501) A23K 50/75 (20160501) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 31/155 (20130101) A61K 31/407 (20130101) A61K 31/496 (20130101) A61K 31/546 (20130101) A61K 31/4164 (20130101) A61K 31/4184 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230096187 | Ziegler et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregory Ray Ziegler (State College, Pennsylvania); Joshua David Lambert (State College, Pennsylvania); Emmanuel Hatzakis (Columbus, Ohio); Eugene P. Mazzola (Vienna, Virginia) |
| ABSTRACT | The present invention provides compounds isolated from avocado seeds for use as a natural colorant in edible materials. The compounds of the invention are useful for coloring edible materials red, orange, or yellow. The invention also provides compositions and methods for coloring edible materials to a desired color such as red, orange, or yellow. |
| FILED | Tuesday, November 22, 2022 |
| APPL NO | 18/058118 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 59/82 (20130101) C07C 2603/30 (20170501) Heterocyclic Compounds C07D 305/10 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 15/24 (20130101) Original (OR) Class C07H 15/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230101936 | Rajwa et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bartlomiej P. Rajwa (West Lafayette, Indiana); Euiwon Bae (West Lafayette, Indiana); J. Paul Robinson (West Lafayette, Indiana); Carmen Gondhalekar (West Lafayette, Indiana); Xi Wu (West Lafayette, Indiana) |
| ABSTRACT | The invention generally relates to methods, reagents, and substrates for detecting target analytes, especially spectroscopic techniques such as laser-induced breakdown spectroscopy (LIBS) for use in food authentication and molecular detection (e.g., when combined with later flow immunoassays (LFIA). |
| FILED | Tuesday, September 27, 2022 |
| APPL NO | 17/953527 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/31 (20130101) Original (OR) Class G01N 33/02 (20130101) G01N 33/6869 (20130101) G01N 2021/3196 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230102379 | ROPER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | M. Caroline ROPER (Riverside, California); Philippe ROLSHAUSEN (Riverside, California); Jonathan LOCKNER (San Diego, California); Katherine MALONEY (San Diego, California); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Califomia, California); POINT LOMA NAZARENE UNIVERSITY (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | M. Caroline ROPER (Riverside, California); Philippe ROLSHAUSEN (Riverside, California); Jonathan LOCKNER (San Diego, California); Katherine MALONEY (San Diego, California) |
| ABSTRACT | Certain embodiments of the invention provide a method of inhibiting Candidatus Liberibacter asiaticus (CLas) growth and/or treating a CLas infection (e.g., Huanglongbing) in a plant, comprising introducing to the plant at least one compound selected from the group consisting of: a cladosporol compound, a radicinin compound (e.g., a compound of formula (I)), and an epicoccamide compound, or a salt thereof. This present invention also provides methods of screening or identifying CLas inhibitory compounds. |
| FILED | Friday, January 22, 2021 |
| APPL NO | 17/794527 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 35/06 (20130101) A01N 43/20 (20130101) A01N 43/36 (20130101) A01N 43/90 (20130101) Original (OR) Class Biocidal, Pest Repellant, Pest Attractant or Plant Growth Regulatory Activity of Chemical Compounds or Preparations A01P 1/00 (20210801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230102954 | Yang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ce Yang (Minneapolis, Minnesota); Brian Steffenson (Minneapolis, Minnesota) |
| ABSTRACT | A method includes applying an image containing a plurality of wheat spikes to a trained neural network to produce a plurality of sub-images, each sub-image comprising a respective single wheat spike segmented from other wheat spikes of the plurality of wheat spikes. Each sub-image is applied to a second trained neural network to produce at least one disease pixel set, wherein each disease pixel set consists of pixels depicting a diseased portion of a wheat spike. |
| FILED | Monday, September 19, 2022 |
| APPL NO | 17/933283 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/0012 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) Image or Video Recognition or Understanding G06V 10/751 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
20230103237 — BIODEGRADABLE PARTICLES AND BIODEGRADABLE PARTICLES IN CONTACT WITH ACTIVE INGREDIENTS
| US 20230103237 | NORTON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | AMIE E. NORTON (MANHATTAN, Kansas); LEE W. COHNSTAEDT (MANHATTAN, Kansas); ROBERT D. EWING (WAMEGO, Kansas); MICHAEL TILLEY (MANHATTAN, Kansas); SCOTT R. BEAN (MANHATTAN, Kansas) |
| ABSTRACT | The invention relates to biodegradable particles and compositions comprising biodegradable particles comprising at least one active ingredient. At least one active ingredient may be inside, throughout, or outside of the biodegradable particle. The at least one active ingredient may be at least one of a pesticide, a dye, an arthropod attractant, an arthropod repellent, an arthropod nutrition supplement, an enhancer of arthropod pest resistance, an enhancer of plant arthropod resistance, an enhancer of plant sprouting and development, a food supplement for mammal consumption, or a combination thereof. The invention further relates to methods for preparing such biodegradable microparticles and compositions, methods of using such biodegradable microparticles and compositions, and kits comprising such biodegradable microparticles and compositions. |
| FILED | Wednesday, September 28, 2022 |
| APPL NO | 17/954632 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 25/006 (20130101) Original (OR) Class A01N 25/26 (20130101) A01N 59/16 (20130101) Biocidal, Pest Repellant, Pest Attractant or Plant Growth Regulatory Activity of Chemical Compounds or Preparations A01P 7/04 (20210801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20230098714 | SUN |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | New York R and D Center for Translational Medicine and Therapeutics, Inc. (New Rochelle, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hui B. SUN (New Rochelle, New York) |
| ABSTRACT | Provided herein are compositions and methods of use for mimicking miRNA activity. For example, these compositions can be effective in modulating expression of pro-inflammatory mediators, such as NLRP3. The compositions can be useful for treating musculoskeletal or connective tissue repair or degenerative conditions, for example, tendinopathy and tendon injury. |
| FILED | Friday, August 05, 2022 |
| APPL NO | 17/882009 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/141 (20130101) C12N 2310/315 (20130101) C12N 2310/321 (20130101) C12N 2310/323 (20130101) C12N 2310/3515 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230098978 | KORMAN |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | INVIZYNE TECHNOLOGIES, INC. (Monrovia, California) |
| ASSIGNEE(S) | INVIZYNE TECHNOLOGIES, INC. (Monrovia, California) |
| INVENTOR(S) | Tyler P. KORMAN (Sierra Madre, California) |
| ABSTRACT | The present disclosure relates to recombinant prenyltransferase enzymes with increased thermostability and activity and the use of these enzymes in compositions and methods for biosynthesis involving prenylation reactions, including compositions and methods for the preparation of cannabinoids. |
| FILED | Thursday, September 22, 2022 |
| APPL NO | 17/934560 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1085 (20130101) Original (OR) Class C12N 15/52 (20130101) C12N 15/8243 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/42 (20130101) Enzymes C12Y 203/01206 (20150701) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230099529 | Selvamanickam et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Houston System (Houston, Texas); AMPeers LLC (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Venkat Selvamanickam (Houston, Texas); Soumen Kar (Houston, Texas) |
| ABSTRACT | A round superconductor wire, method for fabricating same, and method for detecting quench in same are disclosed. Embodiments are directed to a round superconductor wire including a superconductor wire former and at least one superconductor tape wound on the superconductor wire former. Each superconductor tape includes: a substrate; a buffer film stack overlying the substrate; and a superconductor film overlying the buffer film stack. These and other embodiments achieve a round superconductor wire having improved engineering current density in high magnetic field applications when made in small diameters. |
| FILED | Wednesday, December 23, 2020 |
| APPL NO | 17/801984 |
| CURRENT CPC | Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 12/06 (20130101) Original (OR) Class H01B 12/08 (20130101) H01B 13/0036 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230100371 | Zelik et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee); Herowear LLC (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karl Zelik (Nashville, Tennessee); Matthew Yandell (Nashville, Tennessee); Matthew Marino (Nashville, Tennessee); Mark Harris (Nashville, Tennessee); Rebeccah Pailes-Friedman (Nashville, Tennessee); Ryu Tomita (Nashville, Tennessee); Paul Reamey (Nashville, Tennessee); Evan Huggins (Nashville, Tennessee) |
| ABSTRACT | A wearable assistance device, such as an exosuit/exoskeleton, for providing assistance (e.g., assistive force or assistive torque) while reducing lower back muscle stress, fatigue, injury risk and/or pain is disclosed. The wearable assistance device includes adjustable modular straps and/or elastic bands. The modular straps allow swapping of different straps to achieve a custom fit of the wearable assistance device. The modular elastic bands allow swapping of different elastic bands to achieve a preferred level of assistance by the wearable assistance device. |
| FILED | Tuesday, March 16, 2021 |
| APPL NO | 17/798169 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 5/022 (20130101) Original (OR) Class A61F 5/0109 (20130101) A61F 2005/0155 (20130101) A61F 2005/0197 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20230097680 | BONNELL |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES POSTAL SERVICE (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Clayton C. BONNELL (Fairfax, Virginia) |
| ABSTRACT | A method is provided for tracking and/or locating a delivery item. A first delivery-item transport equipment label is temporarily attached to a bracket, wherein the bracket includes a main body with a first identifier permanently attached to the bracket and a second identifier comprising a radio-frequency identification (RFID) chip permanently attached to the bracket. The first delivery-item transport equipment label and at least one of the first identifier and the second identifier are scanned to associate the first delivery-item transport equipment label with at least the RFID chip. The RFID chip is scanned during use of a delivery-item transport equipment to which the bracket is attached. A location of the first delivery-item transport equipment label is identified based on the scanning of the RFID chip. |
| FILED | Wednesday, December 07, 2022 |
| APPL NO | 18/062885 |
| CURRENT CPC | Frames, Casings or Beds of Engines, Machines or Apparatus, Not Specific to Engines, Machines or Apparatus Provided for Elsewhere; Stands; Supports F16M 13/02 (20130101) Displaying; Advertising; Signs; Labels or Name-plates; Seals G09F 7/18 (20130101) Original (OR) Class G09F 21/00 (20130101) G09F 2007/1847 (20130101) G09F 2007/1856 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230098768 | McLellan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles P. McLellan (Fairfax, Virginia); Venkat Mouli (Chantilly, Virginia) |
| ABSTRACT | A system and method for the use of geo-fences to coordinate and track delivery of items. In some embodiments, the system comprising a mobile delivery device comprising a vector calculation module configured to determine a motion vector associated with the mobile delivery device, a geo-location module configured to determine a geo-location associated with a mobile delivery device, and a geo-fence database configured to determine a size of at least one geo-fence associated with at least one location and determine whether the mobile delivery device is within the geo-fence. In some embodiments, the size of the geo-fence is determined at least in part on the motion vector determined by the vector calculation module. |
| FILED | Monday, December 05, 2022 |
| APPL NO | 18/061815 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/0833 (20130101) G06Q 10/08355 (20130101) Original (OR) Class Wireless Communication Networks H04W 4/021 (20130101) H04W 4/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230100359 | TARTAL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES POSTAL SERVICE (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William A. TARTAL (Baltimore, Maryland); Joel L. DEWNANDAN (Bladensburg, Maryland); Joram SHENHAR (Fairfax, Virginia) |
| ABSTRACT | A portable workstation apparatus includes: a pair of collapsible legs; and a work portion that is attached in a removable manner to the pair of collapsible lags via a pair of brackets. Each leg of the pair of collapsible legs includes: a frame; an extension connected to a first end of the frame; a lower post housed within a sleeve; an upper post; a hinge connecting the lower post and the upper post; a first brace connecting the extension to the sleeve; and a plurality of holes on an exterior face of the lower post or the upper post. Each leg is configured to collapse by folding the upper post towards the lower post via the hinge and rotating the extension toward the lower post. |
| FILED | Thursday, December 01, 2022 |
| APPL NO | 18/060867 |
| CURRENT CPC | Tables; Desks; Office Furniture; Cabinets; Drawers; General Details of Furniture A47B 3/08 (20130101) Original (OR) Class A47B 9/14 (20130101) A47B 21/02 (20130101) A47B 83/04 (20130101) A47B 2003/0824 (20130101) A47B 2009/145 (20130101) A47B 2200/004 (20130101) A47B 2200/0029 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230102331 | Bombaugh |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott R. Bombaugh (Burke, Virginia) |
| ABSTRACT | Systems and methods for sorting items for delivery to delivery points, using delivery point compression. Items can be sorted and sequenced for delivery by a sorting machine having a finite number of sorting destinations. For routes having more delivery points than the number of sorting destinations, delivery point compression allows sorting destination assignments that eliminate delivery points not likely to receive any items. Sorting destination assignments can be performed by a processor of the sorting machine based on expected item information and delivery point item frequency scores. |
| FILED | Friday, December 02, 2022 |
| APPL NO | 18/061404 |
| CURRENT CPC | Postal Sorting; Sorting Individual Articles, or Bulk Material Fit to be Sorted Piece-meal, e.g by Picking B07C 3/006 (20130101) Original (OR) Class B07C 3/008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20230095139 | Ohlmeyer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States Department of Veterans Affairs (Washington, District of Columbia); Icahn School of Medicine at Mount Sinai (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Ohlmeyer (New York, New York); Dongming Cai (New York, New York) |
| ABSTRACT | A genus of dihydropyridine chemical modulators of synaptojanin is disclosed. These modulators are selective inhibitors of synaptojanin 1 and may be used to treat cognitive impairment or traumatic brain injury, including promoting regeneration in cases of traumatic brain injury, or for treating neurodegenerative disorders. |
| FILED | Monday, October 10, 2022 |
| APPL NO | 17/963036 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Heterocyclic Compounds C07D 211/90 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230096333 | Higgins |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian Higgins (US, None) |
| ABSTRACT | Methods, systems, and apparatuses are described that are configured for determining a path of an apparatus, engaging a motor to cause the apparatus to proceed along the path, receiving one or more of LIDAR data, ultrasonic data, or optical flow data, determining, based on one or more of the LIDAR data, the ultrasonic data, or the optical flow data, one or more objects in the path of the apparatus, and engaging the motor to cause the apparatus to avoid the one or more objects. |
| FILED | Monday, September 28, 2020 |
| APPL NO | 17/632228 |
| CURRENT CPC | Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 3/061 (20130101) Original (OR) Class A61H 3/068 (20130101) A61H 2003/063 (20130101) A61H 2201/0157 (20130101) A61H 2201/0173 (20130101) A61H 2201/1207 (20130101) A61H 2201/5012 (20130101) A61H 2201/5048 (20130101) A61H 2201/5058 (20130101) A61H 2201/5092 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 15/86 (20200101) G01S 15/93 (20130101) G01S 17/93 (20130101) G01S 19/01 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20230098465 | DAEHN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Glenn DAEHN (Columbus, Ohio); Anupam VIVEK (Columbus, Ohio); Jackson PECK (Columbus, Ohio); Stanley BOVID (Columbus, Ohio) |
| ABSTRACT | Disclosed are methods of forming an impact weld between different metal parts. Also disclosed herein are welded products exhibiting high strength. Also disclosed herein are systems for making such welded products. |
| FILED | Friday, December 18, 2020 |
| APPL NO | 17/787001 |
| CURRENT CPC | Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 11/11 (20130101) Original (OR) Class B23K 20/08 (20130101) B23K 26/322 (20130101) B23K 26/323 (20151001) B23K 2103/20 (20180801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 20230098480 | Che et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Oregon State University (Corvallis, Oregon) |
| ASSIGNEE(S) | Oregon State University (Corvallis, Oregon) |
| INVENTOR(S) | Erzhuo Che (Corvallis, Oregon); Michael Olsen (Corvallis, Oregon) |
| ABSTRACT | A computer implemented scheme for a light detection and ranging (LIDAR) system where point cloud feature extraction and segmentation by efficiently is achieved by: (1) data structuring; (2) edge detection; and (3) region growing. |
| FILED | Wednesday, November 16, 2022 |
| APPL NO | 18/056247 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/4804 (20130101) G01S 17/89 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/13 (20170101) G06T 7/136 (20170101) G06T 7/174 (20170101) G06T 7/187 (20170101) G06T 2207/10028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Environmental Protection Agency (EPA)
| US 20230097058 | Whitehill et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government, as represented by the Administrator of the U.S. EPA (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Richard Whitehill (Durham, North Carolina); Eben Daniel Thoma (Cary, North Carolina); Paul Lemieux (Cary, North Carolina); Mark Higuchi (Chapel Hill, North Carolina); Chelsea Berg (Durham, North Carolina); Brian K. Gullett (Durham, North Carolina); Erin Shields (Cary, North Carolina) |
| ABSTRACT | Methods and systems are provided for processing PFAS-contaminated waste via thermomechanochemical (TMC) processing. In one example, a system may include a TMC processing chamber including a milling system and coupled to a heating system, the heating system configured to co-operate with the milling system to process the waste material. A plurality of containers including the waste material in one or more of a liquid-solid state, a semi-wet or slurry solid state, and a dry solid state are coupled to the TMC chamber. |
| FILED | Wednesday, September 29, 2021 |
| APPL NO | 17/449439 |
| CURRENT CPC | Disposal of Solid Waste B09B 3/0083 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 11/004 (20130101) C02F 11/13 (20190101) C02F 11/18 (20130101) Original (OR) Class C02F 2101/36 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20230102648 | Jovanovic et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Nemanja Jovanovic (Sierra Madre, California); Jeffrey B. Jewell (Pasadena, California); Pradip R. Gatkine (Pasadena, California); Gautam Vasisht (Pasadena, California); Charles A. Beichman (Pasadena, California); Nick Cvetojevic (Nice, France) |
| ABSTRACT | A photonic integrated circuit including an input for receiving input electromagnetic radiation having a bandwidth greater than 60 nm; a spectral splitter splitting the electromagnetic radiation into a plurality of spectral channels; a modulator for modulating an amplitude and a phase of one or more of the spectral channels so as to form modulated outputs; and a spectral recombiner for combining the modulated outputs into a single output port outputting output electromagnetic radiation having the desired output spectral intensity profile shaped by and synthesized from the modulated outputs. |
| FILED | Friday, September 30, 2022 |
| APPL NO | 17/958097 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/12 (20130101) G01J 3/28 (20130101) Original (OR) Class Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/212 (20210101) G02F 1/225 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20230095075 | OU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HP (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jingxing OU (Bethesda, Maryland); Wei LI (Potomac, Maryland); Kiyoharu Joshua MIYAGISHIMA (Laurel, Maryland) |
| ABSTRACT | A composition for preserving viability of cells, tissues, or organs at a low temperature is provided. The composition includes a mitochondrial uncoupling agent, at least one protease inhibitor, and a reducing agent. Methods to protect cells, tissues, or organs from exposure to cold and other metabolic stress are also provided. |
| FILED | Tuesday, November 22, 2022 |
| APPL NO | 18/058064 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/34 (20130101) A61K 31/336 (20130101) A61K 31/4985 (20130101) Original (OR) Class A61K 38/08 (20130101) A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, March 30, 2023.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20230330.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
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