FedInvent™ Patent Applications
Application Details for Thursday, April 06, 2023
This page was updated on Thursday, April 06, 2023 at 05:27 AM GMT
Department of Health and Human Services (HHS)
| US 20230103327 | Powell, Jr. et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of The University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel J. Powell, Jr. (Bala Cynwyd, Pennsylvania); Andrew Tsourkas (Bryn Mawr, Pennsylvania); Nicholas Minutolo (Philadelphia, Pennsylvania) |
| ABSTRACT | The invention provides methods for stimulating a universal immune receptor-mediated response in a mammal using cells engineered to express a universal immune receptor that comprises an adaptor molecule, such as a SpyCatcher or a SpyTag moiety, a transmembrane domain, and an intracellular domain for T cell activation. |
| FILED | Saturday, January 23, 2021 |
| APPL NO | 17/794571 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 38/00 (20130101) A61K 41/00 (20130101) A61K 47/6811 (20170801) A61K 47/6851 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/47 (20130101) C07K 14/315 (20130101) C07K 14/7051 (20130101) C07K 14/70578 (20130101) C07K 16/32 (20130101) C07K 16/2863 (20130101) C07K 2319/02 (20130101) C07K 2319/03 (20130101) C07K 2319/33 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230103330 | NEWTON et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of The University of California (Oakland, California) |
| INVENTOR(S) | Alexandra C NEWTON (San Diego, California); Timothy R BAFFI (San Diego, California); Gordon B MILLS (Portland, Oregon) |
| ABSTRACT | The present disclosure provides biomarkers and methods of use thereof for diagnosing and prognosing pancreatic cancer and other cancers in a subject. The biomarkers comprise protein kinase C (PKC), PH domain and leucine rich repeat protein phosphatase 1 (PHLPP1), and the ratio of PKC/PHLPP1 and can be detected using anti-PKC and/or anti-PHLPP1 antibodies and quantified using immunochemistry techniques. Methods of treating pancreatic cancer with PHLPP1 inhibitors are also provided. |
| FILED | Thursday, March 18, 2021 |
| APPL NO | 17/909908 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57438 (20130101) Original (OR) Class G01N 33/57484 (20130101) G01N 2333/912 (20130101) G01N 2333/916 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230103352 | Fang et al. |
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| FUNDED BY |
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| APPLICANT(S) | Oncoimmune, Inc. (Rahway, New Jersey) |
| ASSIGNEE(S) | Oncoimmune, Inc. (Rahway, New Jersey) |
| INVENTOR(S) | Xianfeng Fang (Guangdong, China PRC); Yang Liu (Potomac, Maryland); Pan Zheng (Potomac, Maryland); Martin Devenport (Gaithersburg, Maryland); Dongling Li (Jiangsu, China PRC); Libing Mu (Guangdong, China PRC) |
| ABSTRACT | Provided is the use of a CD24 protein for treating a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. |
| FILED | Wednesday, February 10, 2021 |
| APPL NO | 17/798481 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/177 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230103362 | MESSICK et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE WISTAR INSTITUTE (PHILADELPHIA, Pennsylvania) |
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| INVENTOR(S) | TROY E. MESSICK (UPPER DARBY, Pennsylvania); PAUL M. LIEBERMAN (WYNNEWOOD, Pennsylvania); GARRY R. SMITH (ELVERSON, Pennsylvania); ARLINDO L. CASTELHANO (NEW YORK, New York) |
| ABSTRACT | The invention relates, in certain aspects, to developable forms of certain compounds that are useful to treat and/or prevent EBV infection and related conditions in a subject. The invention further provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by latent Epstein-Barr Virus (EBV) infection and/or lytic EBV infection. |
| FILED | Friday, August 26, 2022 |
| APPL NO | 17/896767 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 31/404 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) A61P 31/22 (20180101) A61P 35/02 (20180101) Heterocyclic Compounds C07D 405/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230103407 | Qi et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Cincinnati (Cincinnati, Ohio); Children's Hospital Medical Center (Cincinnati, Ohio) |
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| INVENTOR(S) | Xiaoyang Qi (Cincinnati, Ohio); Ying Sun (Cincinnati, Ohio) |
| ABSTRACT | A method of treating a subject suffering from Gaucher Disease is provided, the method including administering to the subject an effective amount of a composition including saposin C, dioleoylphosphatidylserine (SapC-DOPS), and acid β-glucosidase (GCase). Also provided is a nanovesicle including saposin C, dioleoylphosphatidylserine, and acid β-glucosidase and pharmaceutical compositions including the SapC-DOPS-GCase nanovesicles. |
| FILED | Wednesday, March 10, 2021 |
| APPL NO | 17/910105 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/445 (20130101) A61K 31/661 (20130101) A61K 31/4025 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) A61P 3/00 (20180101) Peptides C07K 16/18 (20130101) Original (OR) Class Enzymes C12Y 302/01 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230103452 | Fisher et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland) |
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| INVENTOR(S) | John Patrick Fisher (Kensington, Maryland); Shannon Theresa McLoughlin (Silver Spring, Maryland) |
| ABSTRACT | A system and method for tissue fabrication involves the use of charge manipulation between two biomaterials to generate a shrinking response, which effectively enhances the resolution of bioprinted hydrogels. The charge manipulation can be utilized to generate tissue engineered thin, membranous tissues, such as the periosteum, which is approximately one hundred microns in thickness. Thin membranous tissues in the body also have relatively complex anatomies containing multiple cell populations, and no prior strategies allow for the effective and biomimetic generation of these tissues, which can have significant impact on tissue regeneration. |
| FILED | Thursday, October 06, 2022 |
| APPL NO | 17/938487 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/50 (20130101) Original (OR) Class A61L 27/52 (20130101) A61L 27/222 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230103498 | Li et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
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| INVENTOR(S) | Lingyin Li (Stanford, California); Mark Smith (Stanford, California); Kelsey Erin Shaw (Stanford, California); Jacqueline Ann Carozza (Stanford, California); Volker Boehnert (Stanford, California) |
| ABSTRACT | Compounds, compositions and methods are provided for the inhibition of ENPP1. Aspects of the subject methods include contacting a sample with a ENPP1 inhibitor to inhibit cGAMP hydrolysis activity of ENPP1. In some cases, the ENPP1 inhibitor is cell impermeable. Also provided are compositions and methods for treating cancer. Aspects of the methods include administering to a subject a therapeutically effective amount of a ENPP1 inhibitor to treat the subject for cancer. In certain cases, the cancer is a solid tumor cancer. Also provided are methods of administering radiation therapy to a subject either before or after administering an ENPP1 inhibitor. The radiation therapy can be administered at a dosage and/or frequency effective to reduce radiation damage to the subject. In certain cases, the method is performed in combination with a chemotherapeutic agent, or a checkpoint inhibitor, or both. |
| FILED | Friday, September 30, 2022 |
| APPL NO | 17/957392 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/675 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230103510 | Does et al. |
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| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Netherlands); Northwestern University (Evanston, Illinois) |
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| INVENTOR(S) | Mark D. Does (Nashville, Tennessee); John A. Rogers (Wilmette, Illinois) |
| ABSTRACT | An implantable bioresorbable radio frequency (RF) coil for high-resolution and high-specificity post-surgical evaluating or monitoring with magnetic resonance imaging (MRI) is disclosed. The coil includes a bioresorbable conductor configured to be resorbed within a patient while the coil is implanted in the patient. In one embodiment, the target application of this coil is the evaluation or monitoring (via MRI) of peripheral nerve regeneration following surgical repair. |
| FILED | Monday, March 01, 2021 |
| APPL NO | 17/798193 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/05 (20130101) Original (OR) Class A61B 5/055 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230103554 | Metelitsa et al. |
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| APPLICANT(S) | Baylor College of Medicine (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Leonid S. Metelitsa (Houston, Texas); Julie Tomolonis (Houston, Texas) |
| ABSTRACT | TNFR2-expressing neuroblastoma cells activate monocytes via contact-dependent mTNFα signaling, leading to production of sTNFα and IL-6 by monocytes that in turn bind to TNFR1 and IL-6R on neuroblastoma cells and stimulate tumor growth via activation of NF-κB and Sta3 signaling pathways. Growing tumor recruit additional monocytes resulting in a self-promoting inflammation that fuel tumor growth. TNF inhibitors can terminate this feed-forward signal amplification loop and inhibit tumor growth. Embodiments of the disclosure include a method of using TNF inhibitors for the treatment of neuroblastoma in a subject in need thereof. Also disclosed herein is a method of a method of using TNF inhibitors for reducing tumor-promoting inflammation in an individual with cancer. |
| FILED | Thursday, April 01, 2021 |
| APPL NO | 17/907312 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1793 (20130101) Original (OR) Class A61K 39/3955 (20130101) A61K 45/06 (20130101) A61K 2039/545 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230103708 | Vetter et al. |
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| FUNDED BY |
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| APPLICANT(S) | MUSC Foundation for Research Development (Charleston, South Carolina); University of Utah Research Foundation (Salt Lake City, Utah); University of Florida Research Foundation, Inc. (Gainesville, Florida); The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
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| INVENTOR(S) | Monica Vetter (Salt Lake City, Utah); Alejandra Bosco (Salt Lake City, Utah); Baerbel Rohrer (Charleston, South Carolina); Stephen Tomlinson (Charleston, South Carolina); William W. Hauswirth (Gainesville, Florida) |
| ABSTRACT | Recombinant vectors operably encoding a CR2-FH fusion protein comprising a CR2 portion comprising CR2 protein or a fragment thereof and a FH portion comprising a factor H protein or a fragment thereof, and pharmaceutical compositions comprising the recombinant vector, are described. Also provided are methods of using the compositions for treatment eye diseases such as macular degeneration or glaucoma. |
| FILED | Thursday, June 16, 2022 |
| APPL NO | 17/842225 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/06 (20180101) Peptides C07K 14/70596 (20130101) C07K 2317/23 (20130101) C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/861 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230103909 | Chen et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
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| INVENTOR(S) | Jin Chen (San Francisco, California); Luke Gilbert (San Francisco, California); James Nunez (San Francisco, California); Jonathan Weissman (San Francisco, California) |
| ABSTRACT | Provided herein are, inter alia, compositions and methods for manipulation of genomes of living organisms. |
| FILED | Thursday, April 21, 2022 |
| APPL NO | 17/726290 |
| CURRENT CPC | Peptides C07K 14/4702 (20130101) C07K 2319/09 (20130101) C07K 2319/33 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/20 (20130101) C12N 9/1007 (20130101) C12N 15/62 (20130101) Original (OR) Class C12N 15/113 (20130101) Enzymes C12Y 201/01072 (20130101) C12Y 301/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230103980 | Farooq et al. |
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| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
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| INVENTOR(S) | Abdullah S. Farooq (Pasadena, California); Mohamad H. Abedi (Pasadena, California); Mikhail G. Shapiro (Pasadena, California); Ann Liu (Pasadena, California) |
| ABSTRACT | Disclosed herein include methods, compositions, and kits suitable for use in spatiotemporal regulation of therapeutic macrophages through a combination of molecular and physical actuation. There are provided, in some embodiments, thermal bioswitches that allow macrophages to sense small changes in temperature and use them as inputs for the actuation of genetic circuits. Genetic circuits capable of inducing expression of a payload upon thermal stimulation are provided. There are provided, in some embodiments, heat-inducible macrophages and methods of using are provided. |
| FILED | Monday, October 03, 2022 |
| APPL NO | 17/937614 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 7/52 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) C12N 15/8217 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/53 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230104050 | Wang et al. |
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| FUNDED BY |
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| APPLICANT(S) | SRI International (Menlo Park, California) |
| ASSIGNEE(S) | SRI International (Menlo Park, California) |
| INVENTOR(S) | Denong Wang (Palo Alto, California); Lisa Wu (San Francisco, California) |
| ABSTRACT | Example methods comprise administering an immunogenic vaccine composition to a subject, the immunogenic vaccine composition comprising a glycoconjugate. The method can further comprise, in response to the administration of the immunogenic vaccine composition, inducing production of anti-oligomannose antibodies in the subject and thereby eliciting an immune response to a viral pathogen in the subject. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/907313 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 47/56 (20170801) Original (OR) Class A61K 2039/58 (20130101) Peptides C07K 16/44 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6854 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230104136 | Block et al. |
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| APPLICANT(S) | Drexel University (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Timothy M. Block (Doylestown, Pennsylvania); Mengjun Wang (Mount Pleasant, South Carolina); Anand Mehta (Mount Pleasant, South Carolina); Mary Ann Comunale (Bangor, Pennsylvania) |
| ABSTRACT | Provided are methods, assays, and kits for detecting hepatocellular carcinoma, as well as methods for stratifying subjects among higher and lower risk categories for having hepatocellular carcinoma, and methods of treating and managing treatment of subjects that are suspected or at risk of having hepatocellular carcinoma. Although previous work has attempted to address the need for a highly sensitive, early predictor of hepatocellular carcinoma by assessment of one or more biological factors, none have approached the degree of sensitivity that is required for clinically relevant determination of whether a subject, especially a non-symptomatic subject, has that condition. The present inventors have discovered that certain combinations of factors fulfill this need by conferring a high level of accuracy that was not previously attainable. |
| FILED | Thursday, June 23, 2022 |
| APPL NO | 17/808420 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/16 (20130101) Peptides C07K 16/06 (20130101) C07K 2317/41 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6854 (20130101) G01N 33/6857 (20130101) G01N 33/57438 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230104152 | Noble et al. |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jack H. Noble (Nashville, Tennessee); Erin Bratu (Nashville, Tennessee); Benoit M. Dawant (Nashville, Tennessee); Robert F. Labadie (Nashville, Tennessee); Rene H. Gifford (Franklin, Tennessee) |
| ABSTRACT | A method for active electrode selection in a cochlear implant having an electrode array with a plurality of electrodes implanted in a cochlea of a living subject. The method includes estimating an activation region (AR) of each electrode based on its distance to nerve sites; presenting the AR in a visualization representation, wherein each electrode is represented by a bar having a width or length representing the AR; identifying electrodes having substantial AR overlap if the AR of one electrode overlaps substantially with the AR bar of another electrode; and selecting and deactivating at least one of the identified electrodes with substantial AR overlap. |
| FILED | Tuesday, September 20, 2022 |
| APPL NO | 17/948737 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/36038 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230104170 | CUI et al. |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| INVENTOR(S) | Lina CUI (Gainesville, Florida); Kelton SCHLEYER (Gainesville, Florida) |
| ABSTRACT | In this vein, we present CTLAP, a fluorogenic probe that is rapidly activated by CTL and displays good selectivity over CTB and CTV, the closest competing analytes for CTL activity probes. CTLAP exhibits intrinsically low background fluorescence, which we attribute to the notably low quantum yield measured for the probe. CTLAP demonstrates markedly higher turn-on ratios (24-fold) and moderately improved enzyme selectivity (6- to 10-fold) when compared to Z-FR-AMC (10-fold turn-on ratio, 6- to 7-fold selectivity), a commercially available CTL-selective probe commonly used to detect CTL activity in mixed samples. Optimum selectivity for CTL is achieved within 10 min of incubation with the enzyme, suggesting that CTLAP is amenable for rapid detection of CTL, even in the presence of competing cathepsins. |
| FILED | Saturday, February 06, 2021 |
| APPL NO | 17/797884 |
| CURRENT CPC | Heterocyclic Compounds C07D 409/12 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/582 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230104171 | Rodrigues et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kristen Alexandra Rodrigues (Cumberland, Rhode Island); Sergio A. Rodriguez Aponte (Cambridge, Massachusetts); Neil Dalvie (Cambridge, Massachusetts); Darrell Irvine (Arlington, Massachusetts); J. Christopher Love (Somerville, Massachusetts) |
| ABSTRACT | Compositions are disclosed that include alum and a SARS-CoV-2 Spike (S) glycoprotein variant covalently bound to the alum via at least one linker having 2-12 phosphoserine residues, where the S glycoprotein variant includes a receptor binding domain (RBD) having a mutation of at least one amino acid residue in an angiotensin-converting enzyme 2 (ACE2) receptor binding motif (RBM) relative to a wild-type RBD, where the residue is (i) hydrophobic; and (ii) within an aggregation-prone region of about 3-15 amino acid residues, and the mutation is a substitution of the hydrophobic residue with a different amino acid residue; as are compositions and vaccines including the compositions, and methods for their use. |
| FILED | Friday, July 29, 2022 |
| APPL NO | 17/816061 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/51 (20130101) A61K 39/215 (20130101) Original (OR) Class A61K 2039/55505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/165 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230104317 | Pang et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Baoxu Pang (Stanford, California); Michael P. Snyder (Stanford, California) |
| ABSTRACT | Embodiments herein describe systems and methods to identify genetic silencers. Many embodiments screen one or more DNA fragments to identify sequences that are capable of silencing gene expression. Once identified, silencer elements can be utilized for many applications, including precision medicine. |
| FILED | Monday, February 01, 2021 |
| APPL NO | 17/759917 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/90 (20130101) C12N 15/1086 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230104322 | Hall et al. |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Clayton Hall (Baltimore, Maryland); Livia Casciola-Rosen (Baltimore, Maryland); Antony Rosen (Baltimore, Maryland) |
| ABSTRACT | The present inventors identified a subpopulation of genes induced by type I and type II IFNs in a human submandibular gland (HSG) epithelial cell line. Unexpectedly, it was found that the majority of genes that are highly up-regulated by IFN-α are also highly induced by IFN-γ. In contrast, there was a substantial group of genes that are highly induced by IFN-γ only. In target tissues, this identified subpopulation of genes and probes allow different IFN patterns to be discerned, enabling more precise molecular classification of patient subpopulations. The identified gene probes are useful for selecting and monitoring therapy, and for defining efficacy of novel agents in the autoimmune rheumatic diseases. |
| FILED | Thursday, May 19, 2022 |
| APPL NO | 17/748266 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/564 (20130101) Original (OR) Class G01N 33/6842 (20130101) G01N 33/6866 (20130101) G01N 33/6893 (20130101) G01N 2800/102 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230104480 | Polt et al. |
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| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARO OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robin L. Polt (Tucson, Arizona); Dillon Hanrahan (Tucson, Arizona); Lajos Z. Szabo (Tucson, Arizona); Michael L. Heien (Tucson, Arizona); Chenxi Liu (Tucson, Arizona) |
| ABSTRACT | Methods for quality control and optimizing the formation and characterization of micelles, vesicles or other aggregates are described herein. Pharmaceutically relevant peptides may be modified to form glycopeptide surfactants which form micelles or other aggregates with another surfactant. Glycopeptide and glycolipid surfactants can aggregate to form particles that enhance drug delivery. The glycopeptide surfactants may be drugs or prodrugs which are delivered via the micelles or other aggregated structures. |
| FILED | Monday, November 21, 2022 |
| APPL NO | 18/057665 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1272 (20130101) Original (OR) Class A61K 38/07 (20130101) A61K 38/08 (20130101) A61K 38/085 (20130101) A61K 38/095 (20190101) A61K 38/1866 (20130101) A61K 47/12 (20130101) A61K 47/18 (20130101) A61K 47/20 (20130101) A61K 47/26 (20130101) A61K 47/186 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230104557 | Bailey et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Michael R. Bailey (Seattle, Washington); Adam D. Maxwell (Seattle, Washington); Oleg A. Sapozhnikov (Seattle, Washington) |
| ABSTRACT | Methods and systems for tuning lithotripsy frequency to target size are disclosed. In one embodiment, a lithotripsy system for comminuting a stone in a body includes: a burst wave lithotripsy (BWL) therapy transducer configured to transmit smooth ultrasound waves within a burst of ultrasound waves toward the stone; and a controller configured to determine operating frequency of the ultrasound waves of the therapy transducer. The operating frequency of the ultrasound waves is determined as: |
| FILED | Friday, September 30, 2022 |
| APPL NO | 17/937294 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/2256 (20130101) Original (OR) Class A61B 2017/00141 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230104671 | Zhao |
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| FUNDED BY |
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| APPLICANT(S) | Ann and Robert H. Lurie Children's Hospital of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Youyang Zhao (Deerfield, Illinois) |
| ABSTRACT | Disclosed are methods and compositions for treating cardiovascular diseases including cardiomyopathy and heart failure. Particularly disclosed are methods and compositions that utilize or comprise inhibitors of hypoxia-inducible factor (HIF)-2α or agonists/inducers of HIF prolyl hydroxylase domain-2 (PHD2) signaling for treating cardiomyopathy and heart failure. |
| FILED | Monday, October 03, 2022 |
| APPL NO | 17/937758 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/198 (20130101) A61K 31/277 (20130101) A61K 31/352 (20130101) A61K 31/4706 (20130101) A61K 31/4709 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230104995 | Voitiuk et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kateryna Voitiuk (Santa Cruz, California); David H. Haussler (Santa Cruz, California); Mircea Teodorescu (Santa Cruz, California) |
| ABSTRACT | An electrophysiological recording and stimulation system includes an electrophysiological device coupled to neural tissue and configured to measure neural electrophysiological signals. The system also includes a computing device coupled to the electrophysiological device and configured to receive neural electrophysiological signals from the electrophysiological device, and transmit neural stimulating signals to the neural tissue through the electrophysiological device based on the neural electrophysiological signals. |
| FILED | Tuesday, October 04, 2022 |
| APPL NO | 17/960093 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5082 (20130101) Original (OR) Class Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) G16B 40/20 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230104998 | Estandian et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Daniel Masao Estandian (Cambridge, Massachusetts); Edward Stuart Boyden (Chestnut Hill, Massachusetts); Jacob Joshua Lee Rodriguez (Somerville, Massachusetts) |
| ABSTRACT | The present description provides methods, assays and reagents for linearly expanding a peptide. The methods and/or linear expanded peptide described herein have several uses such as, but not limited to, peptide (protein) sequencing, high-resolution interrogation of the proteome and enabling ultrasensitive diagnostics critical for early detection of diseases. |
| FILED | Wednesday, September 21, 2022 |
| APPL NO | 17/949788 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/58 (20130101) G01N 33/6818 (20130101) Original (OR) Class G01N 2458/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230105008 | Beltran et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts); Universita’ Degli Studi Di Trento (Trento, Italy) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Himisha Beltran (Chestnut Hill, Massachusetts); Francesca Demichelis (Trento, Italy); Gian Marco Franceschini (Aland Di Piave, BL, Italy); Alessandro Romanel (Trento, Italy) |
| ABSTRACT | The present invention is based on the identification of castration resistant neuroendocrine prostate cancer (CRPC-NE) features in the circulation, and relates to methods and compositions of identifying CRPC-NE patients by detecting these features. |
| FILED | Monday, February 08, 2021 |
| APPL NO | 17/796830 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/154 (20130101) C12Q 2600/156 (20130101) C12Q 2600/166 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230105186 | Quinones-Hinojosa et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alfredo Quinones-Hinojosa (Bel Air, Maryland); Jordan Green (Nottingham, Maryland) |
| ABSTRACT | The presently disclosed subject matter provides compositions, methods, and kits for transfecting adipose-derived mesenchymal stem cells (AMSCs) in freshly extracted adipose tissue using nanoparticles comprising biodegradable polymers self-assembled with nucleic acid molecules. The presently disclosed subject matter also provides methods for treating a neurological disease in a patient in need thereof, the method comprising administering the AMSCs transfected with the nucleic acid molecules to the patient, wherein the nucleic acid molecules encode one or more bioactive molecules functional in the treatment of a neurological disease, particularly wherein the neurological disease is a brain tumor. |
| FILED | Tuesday, December 06, 2022 |
| APPL NO | 18/075940 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5146 (20130101) A61K 9/5153 (20130101) A61K 9/5176 (20130101) A61K 31/711 (20130101) A61K 35/28 (20130101) Original (OR) Class A61K 35/761 (20130101) A61K 38/20 (20130101) A61K 38/45 (20130101) A61K 38/208 (20130101) A61K 38/212 (20130101) A61K 38/215 (20130101) A61K 38/1709 (20130101) A61K 38/1875 (20130101) A61K 38/2013 (20130101) A61K 45/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0667 (20130101) C12N 2510/02 (20130101) Enzymes C12Y 207/01021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230105233 | Chilkoti et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ashutosh Chilkoti (Durham, North Carolina); Stefan Roberts (Durham, North Carolina) |
| ABSTRACT | Compositions and methods disclosed herein can provide complex protein-based structures that can be used in biomedical applications. An example composition includes an assembly that includes disordered polypeptides and partially ordered polypeptides. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/798868 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5052 (20130101) Original (OR) Class A61K 9/5089 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230105344 | Lee et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa) |
| ASSIGNEE(S) | UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa) |
| INVENTOR(S) | Dongyoul Lee (Iowa City, Iowa); Michael K. Schultz (Iowa City, Iowa); Mengshi Li (Iowa City, Iowa); Nicholas Baumhover (Iowa City, Iowa); F. Christoper Pigge (Iowa City, Iowa) |
| ABSTRACT | The present invention provides in certain embodiments a carcinoma-targeting conjugate comprising Formula I wherein T is a SST2R targeting ligand, L is a linker, and X is a chelator, for the therapeutic treatment of cancer, and methods of use thereof. |
| FILED | Thursday, January 28, 2021 |
| APPL NO | 17/795792 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/088 (20130101) A61K 51/1036 (20130101) A61K 51/1096 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230105381 | Izgu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | Rutgers, The state University of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | Enver Cagri Izgu (Piscataway, New Jersey); Kern Hast (Jersey City, New Jersey); Zhaojun Jia (Piscataway, New Jersey); Melih Baci (Piscataway, New Jersey) |
| ABSTRACT | The present disclosure relates to compositions and methods useful for the functionalization of surfaces in the absence of a metal catalyst. The compositions include compounds of formula (I), which react with strained alkene-containing compounds, before or after molecular assembly catalyzed by tyrosinase, to afford cycloadducts. The strained alkene-containing compound may further comprise any molecule of interest, including small molecules and macromolecules, thereby enabling surface functionalization. In certain embodiments, the strained alkene-containing molecule comprises a moiety selected from the group consisting of a trans-cyclooctene (TCO), cyclopropene, cyclobutene, and norbornene. |
| FILED | Friday, September 30, 2022 |
| APPL NO | 17/937041 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/14 (20130101) Peptides C07K 5/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230105479 | Lee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Gabsang Lee (Ellicott City, Maryland); Hyesoo Kim (Baltimore, Maryland); InYoung Choi (Baltimore, Maryland); HoTae Lim (Baltimore, Maryland); Alex V. Huynh (Baltimore, Maryland) |
| ABSTRACT | The present invention relates to the field of stem cells. More specifically, the present invention provides compositions and methods for using optogenetics to sustain the pluripotency of stem cells. In one embodiment, a vector comprises a nucleotide sequencing encoding a fusion protein comprising the intracellular domain of fibroblast growth factor 1 receptor (FGFR1) and a photoactivatable domain. |
| FILED | Friday, September 30, 2022 |
| APPL NO | 17/957998 |
| CURRENT CPC | Peptides C07K 14/71 (20130101) C07K 14/405 (20130101) Original (OR) Class C07K 2319/02 (20130101) Apparatus for Enzymology or Microbiology; C12M 31/10 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0606 (20130101) C12N 5/0696 (20130101) C12N 13/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230105484 | Jackson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Travis C. Jackson (Pittsburgh, Pennsylvania); Patrick M. Kochanek (Pittsburgh, Pennsylvania) |
| ABSTRACT | Disclosed herein are novel compounds and methods for the treatment of acute organ injury, including injuries resulting from ischemic events. The compounds may be used to treat organ including the brain, heart, or kidney, which have injured as a result of events such as stroke, cardiac arrest, traumatic brain injury, hemorrhagic shock, or subarachnoid hemorrhage. |
| FILED | Monday, November 28, 2022 |
| APPL NO | 17/994783 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/47 (20130101) A61K 31/381 (20130101) A61K 31/404 (20130101) A61K 31/416 (20130101) Original (OR) Class A61K 31/423 (20130101) A61K 31/428 (20130101) A61K 31/498 (20130101) A61K 31/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230105757 | Schultz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa) |
| ASSIGNEE(S) | UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa) |
| INVENTOR(S) | Michael K. Schultz (Iowa City, Iowa); Somya Kapoor (Iowa City, Iowa); Douglas R. Spitz (Iowa City, Iowa) |
| ABSTRACT | The present invention relates to a process of removing free-unlabeled radionuclides from a radiopharmaceutical prior to administering the radiopharmaceutical to the patient using size-exclusion or ion-exchange mechanisms. |
| FILED | Thursday, November 10, 2022 |
| APPL NO | 17/985015 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/198 (20130101) Original (OR) Class A61K 39/3955 (20130101) A61K 2039/545 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230105847 | L'Orange et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Colorado State University Research Foundation (Fort Collins, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christian L'Orange (Fort Collins, Colorado); John Volckens (Fort Collins, Colorado); David Leith (Chapel Hill, North Carolina); Casey Quinn (Olympia, Washington); Bonnie Young (Fort Collins, Colorado); John Kodros (Fort Collins, Colorado) |
| ABSTRACT | A system may include a computer-readable storage media configured to store instructions. The system may also include one or more processors communicatively coupled to the one or more computer-readable storage media. The one or more processors may be configured to, in response to execution of the instructions, cause the system to perform operations. The operations may include measuring a pressure of a volume while a user wears a mask and breathes. The volume may be defined by an interior surface of the mask and a face of the user. The operations may also include determining a differential pressure due to the mask. The differential pressure may be equal to a difference between the pressure of the volume and an ambient pressure of an environment proximate an exterior surface of the mask. In addition, the operations may include determining a mask leakage rate of the mask based on the differential pressure. |
| FILED | Tuesday, October 04, 2022 |
| APPL NO | 17/960029 |
| CURRENT CPC | Devices, Apparatus or Methods for Life-saving A62B 27/00 (20130101) Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 3/26 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230105900 | McConnell et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY (Hoboken, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George McConnell (Monroe, New York); Hanyan Li (Medford, Massachusetts) |
| ABSTRACT | A method of localizing brain regions for the purpose of guiding placement of electrodes and related implants is disclosed. The inventive method involves effecting a pulse in a patient's brain, temporally aligning readings taken from an electrode at various depths, measuring local field potentials at each depth during interstimulus intervals, performing a coherence analysis comparing the local field potential measurements of the different depths, and determining a corresponding brain region for the depths compared. |
| FILED | Friday, December 09, 2022 |
| APPL NO | 18/064100 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/377 (20210101) A61B 5/4064 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/086 (20170801) A61N 1/0534 (20130101) A61N 1/36067 (20130101) A61N 1/36096 (20130101) A61N 1/36175 (20130101) Original (OR) Class A61N 1/37241 (20130101) A61N 1/37247 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230105995 | Anderson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Karen Anderson (Scottsdale, Arizona); Ching-Wen Hou (Chandler, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karen Anderson (Scottsdale, Arizona); Ching-Wen Hou (Chandler, Arizona) |
| ABSTRACT | Disclosed herein are methods and composition useful for the detection of HPV in a subject sample. |
| FILED | Thursday, September 22, 2022 |
| APPL NO | 17/950308 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/582 (20130101) G01N 33/56983 (20130101) Original (OR) Class G01N 33/57407 (20130101) G01N 2333/025 (20130101) G01N 2469/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230106131 | PEI |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dehua PEI (Colubmus, Ohio) |
| ABSTRACT | The present disclosure provides novel polypeptide conjugates. The polypeptide conjugates disclosed herein comprise a stapled peptide comprising a peptide and at least one staple which holds the peptide in an α-helical conformation, and a cyclic cell-penetrating peptide (cCPP) conjugated, directly or indirectly, to the stapled peptide. The present disclosure demonstrates that cCPPs can be used to confer consistent cell-permeability to stapled peptides. |
| FILED | Friday, August 05, 2022 |
| APPL NO | 17/817836 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/58 (20170801) A61K 47/64 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/001 (20130101) C07K 14/4703 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230106294 | Cheng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elise Lin Cheng (iowa City, Iowa); C. Allan Guymon (Iowa City, Iowa); Marlan R. Hansen (Solon, Iowa); Braden Leigh (Iowa City, Iowa) |
| ABSTRACT | Durable, anti-fouling, crosslinked zwitterionic coatings that are grafted to the surface of a substrate through covalent bonding are disclosed. When exposed to a light source, zwitterionic monomers react with a crosslinker and with activated radicals at the surface of the substrate, simultaneously forming the crosslinked zwitterionic coating and anchoring it to the surface of the substrate. Photomasking techniques can be used to micropattern the zwitterionic coatings. The zwitterionic coatings can be applied to a variety of substrates, including medical devices and systems. |
| FILED | Monday, December 12, 2022 |
| APPL NO | 18/079085 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/16 (20130101) A61L 27/34 (20130101) A61L 29/041 (20130101) A61L 29/085 (20130101) A61L 31/10 (20130101) A61L 31/048 (20130101) A61L 2300/404 (20130101) A61L 2420/08 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/11 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/1675 (20130101) C09D 133/10 (20130101) Original (OR) Class C09D 133/26 (20130101) C09D 151/085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230106465 | Guo |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | West Virginia University (Morgantown, West Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nancy Lan Guo (Morgantown, West Virginia) |
| ABSTRACT | A method of providing a treatment to a patient having non-small cell lung cancer is provided comprising extracting total RNA from a formalin fixed and paraffin embedded tumor of non-small cell lung cancer of a patient after the surgical resection, generating complementary DNA (cDNA) of the extracted total RNA from the patient's tumor, quantifying of mRNA expression of 7 genes of ABCC4 (SEQ ID NO:1), CCL19 (SEQ ID NO:2), SLC39A8 (SEQ ID NO:3), CD27 (SEQ ID NO:4), FUT7 (SEQ ID NO:5), ZNF71 (SEQ ID NO:6), and DAG1 (SEQ ID NO:7), normalizing of the quantification of the 7 genes with the quantification of a control gene UBC (SEQ ID NO:8) or a housekeeping gene, and utilizing the normalized 7 gene mRNA expression quantification to determine whether the patient will benefit from receiving adjuvant chemotherapy or not. |
| FILED | Thursday, March 19, 2020 |
| APPL NO | 17/906315 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/282 (20130101) A61K 33/243 (20190101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57423 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230106738 | PEREPELITSA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Administrators of the Tulane Educational Fund (New Orleans, Louisiana) |
| ASSIGNEE(S) | Administrators of the Tulane Educational Fund (New Orleans, Louisiana) |
| INVENTOR(S) | Victoria PEREPELITSA (New Orleans, Louisiana); Prescott DEININGER (New Orleans, Louisiana) |
| ABSTRACT | The invention provides compositions, methods, kits, and devices for detecting the number and locations of polymorphic LINE-1 (pL1s) elements present in the genome of an individual and for detecting previously unknown pL1s. The inventive compositions, methods, kits, and devices permit the identification of numbers and patterns of pL1 insertions that render a person with such numbers and patterns at higher risk of developing cancer or cognitive disorders compared to persons without such numbers and patterns. |
| FILED | Monday, March 01, 2021 |
| APPL NO | 17/802523 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6827 (20130101) Original (OR) Class C12Q 1/6834 (20130101) C12Q 1/6883 (20130101) C12Q 1/6886 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230106760 | Bewley Clore et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Carole A. Bewley Clore (Bethesda, Maryland); Hongbing Liu (Bethesda, Maryland); Shannon I. Ohlemacher (Bethesda, Maryland) |
| ABSTRACT | Disclosed are compounds represented by the formula:(I), wherein R is as defined herein, and pharmaceutically acceptable salts thereof. Also disclosed are a method of treating a subject in need of treatment for a bacterial infection or a fungal infection, which includes administering to the subject an effective amount of one of the compounds or salts thereof. Further disclosed is a process for producing the compounds and salts thereof. |
| FILED | Tuesday, March 16, 2021 |
| APPL NO | 17/909051 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 7/02 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/205 (20210501) C12N 9/1051 (20130101) C12N 15/52 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/02 (20130101) C12P 19/18 (20130101) C12P 19/58 (20130101) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/01 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230106973 | FORGET et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Marie-Andrée FORGET (Houston, Texas); Chantale BERNATCHEZ (Houston, Texas); Cara HAYMAKER (Houston, Texas); Michael A. CURRAN (Houston, Texas); Patrick HWU (Houston, Texas); Cassian YEE (Houston, Texas) |
| ABSTRACT | Provided herein are methods for the activation and expansion of genetically-modified Tcells, such as tumor infiltrating lymphocytes. In some cases, cells of the embodiments can be used for the therapeutic treatment of human diseases, such as cancer. |
| FILED | Tuesday, February 16, 2021 |
| APPL NO | 17/904479 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/55 (20130101) C07K 14/7051 (20130101) C07K 14/70596 (20130101) C07K 16/2809 (20130101) Original (OR) Class C07K 16/2878 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 5/0638 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230107032 | Mekonnen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AGENEBIO, INC. (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Belew Mekonnen (Gilbertsville, Pennsylvania); John A. Butera (Clarksburg, New Jersey); Jianxing Huang (Bethlehem, Pennsylvania); Hemantbhai Patel (Piscataway, New Jersey); Qin Jiang (Latham, New York); Robert Jason Herr (Voorheesville, New York); Emily Elizabeth Freeman (Voorheesville, New York); Nicholas James Mayhew (Niskayuna, New York) |
| ABSTRACT | This invention relates to benzodiazepine derivatives, compositions comprising therapeutically effective amounts of those derivatives and methods of using those derivatives or compositions in treating cognitive impairment associated with CNS disorders. It also relates to the use of an α5-containing GABAA receptor agonist (e.g., an α5-containing GABAA receptor positive allosteric modulator) in treating cognitive impairment associated with CNS disorders in a subject in need or at risk thereof, including age-related cognitive impairment, Mild Cognitive Impairment (MCI), amnestic MCI, Age-Associated Memory Impairment, Age Related Cognitive Decline, dementia, Alzheimer's Disease (AD), prodromal AD, PTSD, schizophrenia, bipolar disorder, ALS, cancer-therapy-related cognitive impairment, mental retardation, Parkinson's disease, autism spectrum disorders, fragile X disorder, Rett syndrome, compulsive behavior, and substance addiction. It also relates to the use of an α5-containing GABAA receptor agonist (e.g., an α5-containing GABAA receptor positive allosteric modulator) in treating brain cancers (including brain tumors, e.g., medulloblastomas), and cognitive impairment associated therewith. |
| FILED | Monday, June 27, 2022 |
| APPL NO | 17/850144 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/16 (20180101) A61P 25/18 (20180101) A61P 25/28 (20180101) Heterocyclic Compounds C07D 487/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230107049 | Miller et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE CLEVELAND CLINIC FOUNDATION (Cleveland, Ohio); UNIVERSITY OF UTAH, CENTER FOR TECHNOLOGY & VENTURE COMMERCIALIZATION (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aaron Miller (Cleveland, Ohio); Denise Dearing (Salt Lake City, Utah); Manoj Monga (Cleveland, Ohio) |
| ABSTRACT | A method of determining the risk that a subject will develop urinary stone disease (USD) or hyperoxaluria is described. The method includes conducting a differential abundance analysis of the bacteria present in a stool and/or urine sample obtained from the subject, determining the ratio of bacteria associated with health to bacteria associated with USD or hyperoxaluria present in the subject’s stool and/or urine sample, and assigning a level of risk for developing USD or hyperoxaluria based on the ratio. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/802597 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/74 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/06 (20130101) C12Q 1/689 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230107117 | DAS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CITY OF HOPE (Duarte, California); CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California); THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | CITY OF HOPE (Duarte, California); CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California); THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts) |
| INVENTOR(S) | Saumya DAS (Boston, Massachusetts); Ane Miren SALVADOR GARICANO (Boston, Massachusetts); Si-ping HAN (Duarte, California); Lisa SCHERER (Duarte, California); Julia DEROGATIS (Duarte, California); Robin HU (Duarte, California); Sahil SAGAR (Duarte, California); William A. GODDARD, III (Pasadena, California); John ROSSI (Duarte, California) |
| ABSTRACT | Disclosed herein are conditional siRNAs activatable by pro-hypertrophic RNA sequences and use thereof for treating conditions such as cardiac hypertrophy. The conditional siRNAs target calcineurin or HDAC2. |
| FILED | Friday, August 10, 2018 |
| APPL NO | 16/638107 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) Original (OR) Class C12N 15/1137 (20130101) C12N 2310/315 (20130101) C12N 2310/3515 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230107230 | Silverman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard B. Silverman (Winnetka, Illinois); Wei Zhu (Evanston, Illinois) |
| ABSTRACT | Disclosed are amino, fluoro-substituted cyclohexene carboxylic acid compounds. The disclosed compounds and compositions thereof may be utilized in methods for modulating ornithine aminotransferase (OAT) activity, including methods for treating diseases or disorders associated with OAT activity or expression such as cell proliferative diseases and disorders. |
| FILED | Monday, October 26, 2020 |
| APPL NO | 17/771721 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 229/48 (20130101) Original (OR) Class C07C 2601/16 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230107235 | Arboleda-Velasquez |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE SCHEPENS EYE RESEARCH INSTITUTE, INC. (BOSTON, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph F. Arboleda-Velasquez (Newton, Massachusetts) |
| ABSTRACT | The present subject matter provides, inter alia, compositions, formulations, and methods for inhibiting, treating, and preventing small vessel diseases. |
| FILED | Wednesday, August 31, 2022 |
| APPL NO | 17/823824 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/705 (20130101) C07K 16/28 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230107377 | Walther et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center (Torrance, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Frans J. Walther (Redondo Beach, California); Alan J. Waring (Irvine, California); Larry M. Gordon (Torrance, California) |
| ABSTRACT | Peptides suitable for preparation of lung surfactants are described. Examples include one that include a first fragment comprising the amino acid sequence of XWLXRALIKRIQAZI (SEQ ID NO: 1) or a first amino acid sequence having at least 90% sequence identity to SEQ ID NO: 1 and a second fragment comprising the amino acid sequence of RZLPQLVXRLVLRXS (SEQ ID NO: 2) or a second amino acid sequence having at least 90% sequence identity to SEQ ID NO: 2, wherein X is any amino acid but at least one amino acid at the X positions is not cysteine, or Z is any amino acid but at least one amino acid at the Z positions is not methionine. Surfactants that contain such peptides, and related compositions, methods of preparing and using the compositions are also described. |
| FILED | Tuesday, June 28, 2022 |
| APPL NO | 17/851615 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) Peptides C07K 14/785 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230107620 | Breuer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Research Institute at Nationwide Children's (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Breuer (New Albany, Ohio); Robert Strouse (Columbus, Ohio); Yong Ung-Lee (Columbus, Ohio); Cameron Best (Columbus, Ohio); Narutoshi Hibino (Towson, Maryland) |
| ABSTRACT | It has been established that optimizing cell seeding onto tissue engineering vascular grafts (TEVG) is associated with reduced inflammatory responses and reduced post-operative stenosis of TEVG. Cell seeding increased TEVG patency in a dose dependent manner, and TEVG patency improved when more cells were seeded, however duration of incubation time showed minimal effect on TEVG patency. Methods of engineering patient specific TEVG including optimal numbers of cells to maintain graft patency and reduce post-operative stenosis are provided. Closed, single-use customizable systems for seeding TEVG are also provided. Preferably the systems are custom-designed based on morphology of the patient specific graft, to enhance the efficacy of cell seeding. |
| FILED | Thursday, December 08, 2022 |
| APPL NO | 18/063600 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) A61L 27/20 (20130101) A61L 27/24 (20130101) A61L 27/54 (20130101) A61L 27/58 (20130101) A61L 27/507 (20130101) A61L 27/3834 (20130101) Original (OR) Class A61L 2300/41 (20130101) A61L 2300/414 (20130101) A61L 2300/416 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 80/00 (20141201) Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/0076 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230107644 | Kobie et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Rochester (Rochester, New York) |
| ASSIGNEE(S) | University of Rochester (Rochester, New York) |
| INVENTOR(S) | James J. Kobie (Rochester, New York); Luis Martinez-Sobrido (Rochester, New York); Michael Piepenbrink (Rochester, New York); Aitor Nogales (Rochester, New York) |
| ABSTRACT | The present disclosure relates to neutralizing anti-influenza monoclonal antibodies. The disclosure further relates to therapeutic uses of the isolated antibody. The antibodies are either directed against Hemagglutinin (HA) and Neuraminidase (NA) of Influenza H3N2. |
| FILED | Thursday, March 25, 2021 |
| APPL NO | 17/907126 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) Peptides C07K 16/1018 (20130101) Original (OR) Class C07K 2317/14 (20130101) C07K 2317/21 (20130101) C07K 2317/24 (20130101) C07K 2317/52 (20130101) C07K 2317/76 (20130101) C07K 2317/565 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230107647 | MARCOTTE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| INVENTOR(S) | Edward MARCOTTE (Austin, Texas); Eric V. ANSLYN (Austin, Texas); Andrew ELLINGTON (Austin, Texas); Jagannath SWAMINATHAN (Austin, Texas) |
| ABSTRACT | Identifying proteins and peptides, and more specifically large-scale sequencing of single peptides in a mixture of diverse peptides at the single molecule level is an unmet challenge in the field of protein sequencing. Herein are methods for identifying amino acids in peptides, including peptides comprising unnatural amino acids. In one embodiment, the N-terminal amino acid is labeled with a first label and an internal amino acid is labeled with a second label. In some embodiments, the labels are fluorescent labels. In other embodiments, the internal amino acid is Lysine. In other embodiments, amino acids in peptides are identified based on the fluorescent signature for each peptide at the single molecule level. |
| FILED | Thursday, July 07, 2022 |
| APPL NO | 17/811284 |
| CURRENT CPC | Peptides C07K 17/08 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/58 (20130101) G01N 33/582 (20130101) G01N 33/6818 (20130101) G01N 33/6824 (20130101) Original (OR) Class G01N 2570/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230107757 | GREEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | JORDAN GREEN (NOTTINGHAM, Maryland); JAYOUNG KIM (BALTIMORE, Maryland); STEPHANY TZENG (SOMERVILLE, Massachusetts) |
| ABSTRACT | Polyethylene glycol (PEG)-b-poly(β-amino ester) (PBAE) co-polymers (PEG-PBAE) and blends of PEG-PBAEs and PBAEs and their use for delivering drugs, genes, and other pharmaceutical or therapeutic agents safely and effectively to different sites in the body and to different cells, such as cancer cells, are disclosed. |
| FILED | Friday, July 15, 2022 |
| APPL NO | 17/865822 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1075 (20130101) A61K 47/59 (20170801) A61K 47/60 (20170801) A61K 47/6907 (20170801) A61K 47/6935 (20170801) A61K 48/0041 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/00 (20180101) A61P 35/00 (20180101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/672 (20130101) C08G 63/916 (20130101) C08G 63/6856 (20130101) C08G 63/6886 (20130101) C08G 73/024 (20130101) C08G 73/0253 (20130101) Original (OR) Class C08G 75/12 (20130101) C08G 81/00 (20130101) C08G 2261/126 (20130101) Compositions of Macromolecular Compounds C08L 71/02 (20130101) C08L 2205/05 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/88 (20130101) C12N 15/113 (20130101) C12N 2310/14 (20130101) C12N 2310/351 (20130101) C12N 2320/32 (20130101) C12N 2710/16643 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230107770 | RODRIGUEZ et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paulo C. RODRIGUEZ (Tampa, Florida); Jose R. Conejo GARCIA (Tampa, Florida); Frederick L. LOCKE (Lutz, Florida) |
| ABSTRACT | Disclosed are compositions and methods for mediating immunosuppressive myelopoiesis. Additionally, disclosed herein are combination therapies for treating cancers and methods of using the same. |
| FILED | Monday, February 22, 2021 |
| APPL NO | 17/801123 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 38/00 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/47 (20130101) C07K 14/4702 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/12 (20130101) C12N 9/1205 (20130101) Enzymes C12Y 207/11 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230107804 | Murthy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shashi K. Murthy (Newton, Massachusetts); Bradley B. Collier (Jamaica Plain, Massachusetts) |
| ABSTRACT | Devices, systems, and methods can be used for the automated production of dendritic cells (DC) from dendritic cell progenitors, such as monocytes obtained from peripheral blood. The invention makes it possible to obtain sufficient quantities of a subject's own DC for use in preparing and characterizing vaccines, for activating and characterizing the activation state of the subject's immune response, and to aid in preventing and/or treating cancer or infectious disease. |
| FILED | Monday, December 05, 2022 |
| APPL NO | 18/061732 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/00 (20130101) Peptides C07K 14/525 (20130101) C07K 14/535 (20130101) C07K 14/545 (20130101) C07K 14/5406 (20130101) C07K 14/5412 (20130101) Apparatus for Enzymology or Microbiology; C12M 1/22 (20130101) C12M 23/16 (20130101) C12M 23/42 (20130101) C12M 25/02 (20130101) C12M 29/10 (20130101) C12M 41/14 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0018 (20130101) C12N 5/0639 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230108025 | PATTNAIK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bikash PATTNAIK (Middleton, Wisconsin); Pawan SHAHI (Madison, Wisconsin) |
| ABSTRACT | The present invention is directed to improved AAV gene therapy constructs and pharmaceutical compositions for the expression of Kir7.1. The gene therapy constructs are particularly AAV vector comprising a promoter operably connected to a polynucleotide encoding a Kir7.1 polypeptide which is capable of being expressed in retinal pigment epithelium cells. Methods of treating a subject having a condition associated with insufficient expression or function of a Kir7.1 polypeptide are also provided. |
| FILED | Monday, March 15, 2021 |
| APPL NO | 17/911367 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/005 (20130101) Original (OR) Class A61K 48/0058 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2750/14143 (20130101) C12N 2830/008 (20130101) C12N 2830/48 (20130101) C12N 2830/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230108071 | Jia et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | OREGON HEALTH & SCIENCE UNIVERSITY (Portland, Oregon) |
| ASSIGNEE(S) | OREGON HEALTH & SCIENCE UNIVERSITY (Portland, Oregon) |
| INVENTOR(S) | Yali Jia (Portland, Oregon); Xiang WEI (Portland, Oregon) |
| ABSTRACT | Disclosed herein are methods and systems for self-tracking of motion artifacts (e.g., due to eye blinking and/or micro saccades motion) in optical coherence tomography (OCT) and/or OCT angiography (OCTA). A motion strength index (MSI) may be determined based on OCTA data, and the presence of excessive motion may be determined based on the MSI (e.g., if the MSI is greater than a threshold). The system may re-acquire OCT data at scan locations for which excessive motion is detected. A cross (X) scanning pattern for alignment is also described. Other embodiments may be described and claimed. |
| FILED | Friday, January 29, 2021 |
| APPL NO | 17/796066 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/102 (20130101) Original (OR) Class A61B 5/0066 (20130101) Image Data Processing or Generation, in General G06T 2207/10101 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230108123 | BARRETT et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Lindy BARRETT (Cambridge, Massachusetts); Sara G. SUSCO (Cambridge, Massachusetts); Eugene YEO (Oakland, California); Stefan AIGNER (Oakland, California); En-Ching LUO (Oakland, California) |
| ABSTRACT | Described and featured are compositions and methods for treating developmental, neurodevelopmental (e.g., Fragile X syndrome (FXS) or Down syndrome (DS)), or neurodegenerative diseases or disorders (e.g., Alzheimer's disease (AD)) by increasing expression of Fragile X Mental Retardation Protein (FMRP) in patients having or having a propensity to develop such diseases or disorders. |
| FILED | Thursday, March 25, 2021 |
| APPL NO | 17/914121 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) Original (OR) Class A61K 48/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230108258 | Cho et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Sooyeon Cho (Boston, Massachusetts); Michael Strano (Lexington, Massachusetts); Xiaojia Jin (Cambridge, Massachusetts); Xun Gong (Boston, Massachusetts); Sungyun Yang (Cambridge, Massachusetts); Jianqiao Cui (Cambridge, Massachusetts) |
| ABSTRACT | Corona phase molecular recognition (CoPhMoRe) that enables the molecular recognition of SARS-CoV-2 viral proteins without the need for antibody or enzymatic receptor incorporation. |
| FILED | Friday, August 05, 2022 |
| APPL NO | 17/881754 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 65/33396 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/70 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230108270 | Freeman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Bruce A. Freeman (Pittsburgh, Pennsylvania); Francisco J. Schopfer (Pittsburgh, Pennsylvania); Sonia R. Salvatore (Pittsburgh, Pennsylvania) |
| ABSTRACT | A composition comprising a complex of a cyclodextrin with a nitroalkene. |
| FILED | Monday, March 15, 2021 |
| APPL NO | 17/909601 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6951 (20170801) Original (OR) Class Acyclic or Carbocyclic Compounds C07C 205/50 (20130101) Polysaccharides; Derivatives Thereof C08B 37/0015 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230108300 | Powell et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel J. Powell (Bala Cynwyd, Pennsylvania); Stephen J. Schuster (Springfield, Pennsylvania); Lauren Shaw (Philadelphia, Pennsylvania) |
| ABSTRACT | Provided is a chimeric antigen receptor (CAR) comprising a domain that binds a Vβ region of a T cell receptor. Also provided is a T cell genetically modified to express the CAR, and methods for treating cancer in a subject in need thereof. |
| FILED | Friday, January 29, 2021 |
| APPL NO | 17/759679 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Peptides C07K 14/7051 (20130101) Original (OR) Class C07K 16/2809 (20130101) C07K 2317/622 (20130101) C07K 2319/03 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230108316 | Hong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF UTAH RESEARCH FOUNDATION (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | TingTing Hong (Salt Lake City, Utah); Robin Mark Shaw (Salt Lake City, Utah) |
| ABSTRACT | Described herein are compositions comprising viral vectors. The viral vectors may encode a t-tubule organizing protein or peptide such as cardiac isoform of bridging integrator 1 (cBIN1). Also disclosed herein are methods for treatment or prophylaxis of heart failure in a subject in need thereof. The method of treatment or prophylaxis may include administering a vector comprising cBIN1 to the subject for rehabilitating or increasing contractile (systolic) function or relaxation (diastolic) function in the heart of a subject having experienced heart failure or having chronic myocardial stress. |
| FILED | Wednesday, April 07, 2021 |
| APPL NO | 17/801002 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1719 (20130101) Original (OR) Class A61K 48/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230108385 | Zhang |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| ASSIGNEE(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| INVENTOR(S) | Huang-Ge Zhang (Louisville, Kentucky) |
| ABSTRACT | Microvesicle compositions and methods of use thereof are provided. The microvesicle composition includes a miRNA encapsulated by a microvesicle, wherein the microvesicle is derived from an edible plant. The method of use thereof includes treating a cancer in a subject by administering to the subject an effective amount of a microvesicle composition. |
| FILED | Thursday, May 26, 2022 |
| APPL NO | 17/825384 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0043 (20130101) A61K 9/0053 (20130101) A61K 9/127 (20130101) A61K 9/1271 (20130101) A61K 31/7088 (20130101) A61K 47/12 (20130101) A61K 47/18 (20130101) A61K 47/46 (20130101) A61K 47/59 (20170801) A61K 47/551 (20170801) A61K 47/6907 (20170801) A61K 47/6929 (20170801) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2310/141 (20130101) C12N 2320/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230108479 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chunming Liu (Lexington, Kentucky); David S. Watt (Lexington, Kentucky); Wen Zhang (Lexington, Kentucky); Vitaliy M. Sviripa (Lexington, Kentucky) |
| ABSTRACT | Provided herein are compounds for inhibiting Wnt signaling and methods of treating cancer. The compounds include any compound having a structure according to Formula II. The method includes administering one or more compounds according to Formula I and/or Formula II to a subject in need thereof. |
| FILED | Thursday, March 04, 2021 |
| APPL NO | 17/907943 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/47 (20130101) A61K 31/4709 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230108494 | Trader et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Darci J. Trader (West Lafayette, Indiana); Breanna Zerfas (Lafayette, Indiana); Andres Salazar-Chaparro (West Lafayette, Indiana) |
| ABSTRACT | The disclosure relates to a compound of the formula (I) and the use of such compounds. |
| FILED | Thursday, March 11, 2021 |
| APPL NO | 17/905921 |
| CURRENT CPC | Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 11/08 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) C09K 2211/1018 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 33/582 (20130101) Original (OR) Class G01N 33/5011 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230108784 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| INVENTOR(S) | Feng Zhang (Cambridge, Massachusetts); David Arthur Scott (Cambridge, Massachusetts); Winston Xia Yan (Cambridge, Massachusetts); Sourav Choudhury (Cambridge, Massachusetts); Matthias Heidenreich (Cambridge, Massachusetts) |
| ABSTRACT | Embodiments disclosed herein are directed to engineered CRISPR-Cas effector proteins that comprise at least one modification compared to an unmodified CRISPR-Cas effector protein that enhances binding of the of the CRISPR complex to the binding site and/or alters editing preference as compared to wild type. In certain example embodiments, the CRISPR-Cas effector protein is a Type V effector protein. In certain other example embodiments, the Type V effector protein is Cpf1. Embodiments disclosed herein are directed to viral vectors for delivery of CRISPR-Cas effector proteins, including Cpf1. In certain example embodiments, the vectors are designed so as to allow packaging of the CRISPR-Cas effector protein within a single vector. There is also an increased interest in the design of compact promoters for packing and thus expressing larger transgenes for targeted delivery and tissue-specificity. Thus, in another aspect certain embodiments disclosed herein are directed to delivery vectors, constructs, and methods of delivering larger genes for systemic delivery. |
| FILED | Wednesday, May 11, 2022 |
| APPL NO | 17/742127 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1271 (20130101) A61K 9/5184 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) C12N 15/113 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2310/32 (20130101) C12N 2740/13042 (20130101) C12N 2740/13043 (20130101) C12N 2800/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230108947 | APPEL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric A. APPEL (Palo Alto, California); Caitlin MAIKAWA (Boston, Massachusetts); Joseph L. Mann (Mountain View, California) |
| ABSTRACT | A polyacrylamide-based copolymer reduces or prevents aggregation of biologic molecules including proteins, peptides, and nucleic acids, and lipid-based vehicles such as liposomes, lipid nanoparticles, polymerosomes, and micelles, in aqueous formulations at hydrophobic interfaces, thereby increasing the thermal stability of the molecules in the formulation. Methods and compositions comprising the copolymer and a protein or the copolymer and insulin can be used for treating conditions including diabetes. |
| FILED | Friday, October 07, 2022 |
| APPL NO | 17/962252 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1272 (20130101) A61K 9/5146 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 220/36 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230109020 | AKSIMENTIEV et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois); Cambridge Enterprise Limited (Cambridge, United Kingdom) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aleksei AKSIMENTIEV (Urbana, Illinois); Ulrich F. KEYSER (Cambridge, United Kingdom) |
| ABSTRACT | The present invention provides compositions and methods for transferring phospholipids and other molecules between the leaflets of a cell membrane. The compositions comprise at least one nucleic acid or compound having a hydrophilic region, where the composition is able to form a nanostructure that forms a toroidal pore in a lipid membrane. The nucleic acid or hydrophilic region-containing compound further contains an attached molecule capable of inserting the nanostructure into the lipid membrane. The invention also provides methods for scrambling lipids and other molecules in a cell membrane, which can be used to alter the function of a selected cell or to facilitate the death of the cell. The scrambling activity of synthetic scramblases described herein outperforms previously known enzymatically active DNA nanostructures and naturally occurring scramblases, in some cases by several orders of magnitude. |
| FILED | Friday, September 09, 2022 |
| APPL NO | 17/941835 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5146 (20130101) A61K 31/711 (20130101) A61K 31/713 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0006 (20130101) Original (OR) Class C12N 15/11 (20130101) C12N 15/111 (20130101) C12N 2310/3515 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230109065 | CHIANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew CHIANG (New York, New York); Dennis VITKUP (New York, New York); Jonathan CHANG (Los Altos, California); Jiayao WANG (New York, New York) |
| ABSTRACT | It was discovered that, for individuals with certain types of mutations, clinical outcomes or phenotypes can be very accurately predicted. For example, for an individual with autism harboring a de novo LGD mutation, the patient’s IQ, behavioral phenotypes, and motor/movement phenotypes, and the severity of autism can be predicted. For these LGD mutations, due to a mRNA surveillance mechanism called NMD (nonsense-mediated decay), it was discovered that clinical outcomes and phenotypes are strongly correlated with the expression intensity of the exon harboring the mutation. A method/model was developed, which is called PDS (phenotype dosage sensitivity), to predict phenotypes based on this observation, and the model is able to predict phenotypes at a much higher level of accuracy not previously possible. This disclosure is the first to link LGD mutations and clinical phenotypes in this manner. |
| FILED | Wednesday, September 28, 2022 |
| APPL NO | 17/935957 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230109070 | Richman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees og the Leland Standford Junior University (Standford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ethan B. Richman (Woodside, California); William E. Allen (Albany, California); Karl A. Deisseroth (Stanford, California) |
| ABSTRACT | Provided herein are devices, methods, and systems for in situ gene sequencing of a target nucleic acid in a cell in an intact tissue. Methods of screening a candidate agent to determine whether the candidate agent modulates gene expression of a nucleic acid in a cell in an intact tissue are also provided herein. |
| FILED | Thursday, October 15, 2020 |
| APPL NO | 17/768996 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50851 (20130101) B01L 7/52 (20130101) B01L 2200/026 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6841 (20130101) C12Q 1/6869 (20130101) Original (OR) Class C12Q 2521/501 (20130101) C12Q 2531/125 (20130101) C12Q 2535/125 (20130101) C12Q 2563/107 (20130101) C12Q 2563/179 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230109146 | Gaehle |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Gregory Gaehle (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Gregory Gaehle (St. Louis, Missouri) |
| ABSTRACT | Among the various aspects of the present disclosure is the provision of methods for producing radioisotopes and improving the specific activity of radioisotopes (e.g., Cu-64 chloride). As described herein, the method includes matching of the target material and the proton beam strike area or the proton beam strike shape, resulting in improved specific activity while reducing the amount of target material used. |
| FILED | Wednesday, October 05, 2022 |
| APPL NO | 17/960279 |
| CURRENT CPC | Conversion of Chemical Elements; Radioactive Sources G21G 1/10 (20130101) Original (OR) Class G21G 2001/0094 (20130101) Techniques for Handling Particles or Ionising Radiation Not Otherwise Provided For; Irradiation Devices; Gamma Ray or X-ray Microscopes G21K 5/08 (20130101) Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 6/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230109152 | Jin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhiyang Jin (Pasadena, California); Mikhail G. Shapiro (Pasadena, California); Anupama Lakshmanan (Seattle, Washington); Teresa Tran (Los Angeles, California) |
| ABSTRACT | Disclosed herein include methods, compositions, and kits suitable for use in calcium imaging. There are provided, in some embodiments, Ca2+-sensing GvpC proteins. Disclosed herein include Ca2+-sensing gas vesicles (GVs) comprising Ca2+-sensing GvpC proteins. In some embodiments, the Ca2+-sensing GvpC protein is capable of undergoing a first allosteric conformational change upon the Ca2+-binding domain binding Ca2+ that causes the Ca2+-sensing GV to change from a GV stiff state to a GV soft state. One or more of the mechanical, acoustic, surface, and magnetic properties of a Ca2+-sensing GV can differ between the GV soft state and the GV stiff state. |
| FILED | Tuesday, October 04, 2022 |
| APPL NO | 17/937975 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/08 (20130101) Peptides C07K 14/005 (20130101) C07K 14/195 (20130101) C07K 14/215 (20130101) C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0686 (20130101) C12N 15/85 (20130101) C12N 15/625 (20130101) C12N 2503/00 (20130101) C12N 2800/107 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6897 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230109193 | Irvine et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Darrell Irvine (Arlington, Massachusetts); Kristen Alexandra Rodrigues (Cumberland, Rhode Island) |
| ABSTRACT | Compositions are disclosed that include alum and a non-liposome, non-micelle particle, where the particle comprises a lipid, a sterol, a saponin, and an optional additional non-alum adjuvant, wherein the particle is optionally bound to the alum, and the use of the compositions as vaccine adjuvants and methods for eliciting immune responses. |
| FILED | Friday, July 29, 2022 |
| APPL NO | 17/816045 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) Original (OR) Class A61K 2039/55572 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230109376 | Swerdlow et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Kansas (Lawrence, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Russell Swerdlow (Leawood, Kansas); Laird Forrest (Lawrence, Kansas); Jordan Hunt (Lawrence, Kansas); Heather Wilkins (Kansas City, Kansas); Eli Michaelis (Lawrence, Kansas) |
| ABSTRACT | Compounds, compositions, and methods related to bioenergetic metabolism are provided. The compounds and compositions are suited to promote bioenergetic processes including cellular respiration and glycolytic flux and may be used to treat mitochondrial disorders, neurodegenerative diseases (such as Alzheimer's disease (AD), Parkinson's disease, and/or amyotrophic lateral sclerosis), multiple sclerosis, and/or epilepsy. |
| FILED | Monday, May 16, 2022 |
| APPL NO | 17/745773 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Acyclic or Carbocyclic Compounds C07C 69/716 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230109434 | Styczynski et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark Styczynski (Atlanta, Georgia); Elizabeth Hutson Chilton (Atlanta, Georgia); Emily Heckard (Atlanta, Georgia) |
| ABSTRACT | An exemplary embodiment of the present disclosure provides a biosensor that can facilitate detection of the molecules creatinine, creatine and/or sarcosine in a minimal-equipment, portable, and low-cost fashion. Some aspects of the disclosure relate to methods and systems to enable quantitative measurement of certain biomarkers at the point of care without expensive instrumentation. |
| FILED | Tuesday, October 04, 2022 |
| APPL NO | 17/937968 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/78 (20130101) G01N 33/70 (20130101) Original (OR) Class G01N 33/96 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230109455 | Zeng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Oakland University (Rochester, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiangqun Zeng (Rochester Hills, Michigan); Yongan Tang (Huntley, Illinois) |
| ABSTRACT | In an example of a selective, real-time gas sensing method, a gas sample, potentially including a specific gas molecule to be sensed, is supplied to an interface between a working electrode and an ionic liquid electrolyte. Based on at least one unique electrochemical reaction of the specific gas molecule to be sensed, a driving force is implemented to initiate a series of reactions involving the specific gas molecule. In response to the implementation of the driving force, a signal indicative of the specific gas molecule is monitored for. |
| FILED | Tuesday, December 06, 2022 |
| APPL NO | 18/076123 |
| CURRENT CPC | Gas-flow Silencers or Exhaust Apparatus for Machines or Engines in General; Gas-flow Silencers or Exhaust Apparatus for Internal Combustion Engines F01N 2560/02 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/407 (20130101) G01N 27/4045 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230109457 | Haudenschild et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents Of The University Of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dominik Haudenschild (Davis, California); Paul Di Cesare (Sacramento, California); Jasper Yik (Elk Grove, California); Blaine Christiansen (Woodland, California) |
| ABSTRACT | The present invention relates to the use of cyclin-dependent kinase 9 (CDK9) inhibitors to reduce, inhibit and/or prevent cartilage degradation. CDK9 inhibitors can be used to reduce, inhibit and/or prevent cartilage degradation and loss of cartilage viability during allograft storage. CDK9 inhibitors can be used as a post-injury intervention treatment to reduce, inhibit and/or prevent the acute cellular responses that lead to future cartilage degradation and osteoarthritis. |
| FILED | Monday, May 09, 2022 |
| APPL NO | 17/739401 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0226 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/453 (20130101) Original (OR) Class A61K 31/713 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230109468 | Huang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Po-Hsun Huang (Quincy, Massachusetts); Cullen Richard Buie (Cambridge, Massachusetts); Sijie Chen (Cambridge, Massachusetts) |
| ABSTRACT | A disposable, fabrication-free, high-volume electroporation device may process cell samples of large volume without compromising transformation efficiency and cell viability, while precipitously reducing the entire processing time and effort. An embodiment includes at least two hollow, tubular conductive elements and an insulating structure, defining a channel, that fluidically couples the at least two conductive elements to define an electroporation flow path in the channel for flow-through electroporation. The high-volume electroporation device can be an alternative to cuvettes for typical volume electroporation, but can also be an indispensable tool to process large volume samples for applications, such as creation of modified sample libraries. |
| FILED | Tuesday, September 27, 2022 |
| APPL NO | 17/935844 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 1/42 (20130101) C12M 29/00 (20130101) C12M 35/02 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 13/00 (20130101) C12N 15/87 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230109667 | Abate et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam R. Abate (Daly City, California); Dennis Jay Eastburn (Burlingame, California); Adam R. Sciambi (San Francisco, California); Shaun Lim (Singapore, Singapore) |
| ABSTRACT | The methods described herein, referred to as PCR-Activated Sorting (PAS), allow nucleic acids contained in biological systems to be sorted based on their sequence as detected with nucleic acid amplification techniques, e.g., PCR. The nucleic acids can be free floating or contained within living or nonliving structures, including particles, viruses, and cells. The nucleic acids can include, e.g., DNA or RNA. Systems and devices for use in practicing methods of the invention are also provided. |
| FILED | Thursday, March 17, 2022 |
| APPL NO | 17/697502 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/70 (20130101) C12Q 1/686 (20130101) Original (OR) Class C12Q 1/689 (20130101) C12Q 1/6886 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20230103444 | LaBARBERA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a Body Corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel V. LaBARBERA (Aurora, Colorado); Joshua M. ABBOTT (Silver Spring, Maryland); Qiong ZHOU (Aurora, Colorado); Adedoyin D. ABRAHAM (Thornton, Colorado); Hector ESQUER (Aurora, Colorado); Brett Joseph PRIGARO (Broomfield, Colorado); Laura Anne PIKE (Aurora, Colorado); Paul AWOLADE (Aurora, Colorado) |
| ABSTRACT | Treatment of CHD1L-driven cancers, including TCF transcription-driven cancers and EMT-driven cancers using CHD1L inhibitors. Small molecule inhibitors of CHDL1 which inhibit CHD1L ATPase and inhibit CHD1L-dependent TCF-transcription have been identified. CHD1L inhibitors prevent the TCF-complex from binding to Wnt response elements and promoter sites. More specifically, CHD1L inhibitors induce the reversion of EMT. CHD1L inhibitors are useful in the treatment of various cancers and particularly CRC and m-CRC. The CHD1L-driven cancer is among others, CRC, breast cancer, glioma, liver cancer, lung cancer or gastrointestinal (GI) cancers. CHD1L inhibitors of formulas I and XX and salts thereof as defined herein are provided as well as pharmaceutical compositions containing CHD1L inhibitors. Synergistic combinations of CHD1L inhibitors with other antineoplastic agents are also described. |
| FILED | Monday, September 26, 2022 |
| APPL NO | 17/953221 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 263/46 (20130101) C07D 265/30 (20130101) Original (OR) Class C07D 403/04 (20130101) C07D 403/14 (20130101) C07D 409/12 (20130101) C07D 409/14 (20130101) C07D 413/04 (20130101) C07D 417/12 (20130101) C07D 471/04 (20130101) C07D 519/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230103498 | Li et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lingyin Li (Stanford, California); Mark Smith (Stanford, California); Kelsey Erin Shaw (Stanford, California); Jacqueline Ann Carozza (Stanford, California); Volker Boehnert (Stanford, California) |
| ABSTRACT | Compounds, compositions and methods are provided for the inhibition of ENPP1. Aspects of the subject methods include contacting a sample with a ENPP1 inhibitor to inhibit cGAMP hydrolysis activity of ENPP1. In some cases, the ENPP1 inhibitor is cell impermeable. Also provided are compositions and methods for treating cancer. Aspects of the methods include administering to a subject a therapeutically effective amount of a ENPP1 inhibitor to treat the subject for cancer. In certain cases, the cancer is a solid tumor cancer. Also provided are methods of administering radiation therapy to a subject either before or after administering an ENPP1 inhibitor. The radiation therapy can be administered at a dosage and/or frequency effective to reduce radiation damage to the subject. In certain cases, the method is performed in combination with a chemotherapeutic agent, or a checkpoint inhibitor, or both. |
| FILED | Friday, September 30, 2022 |
| APPL NO | 17/957392 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/675 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230103690 | ROGERS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois); THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John A. ROGERS (Wilmette, Illinois); Hui FANG (Urbana, Illinois); Jianing ZHAO (Urbana, Illinois); Enming SONG (Urbana, Illinois); Yoon Kyeung LEE (Urbana, Illinois) |
| ABSTRACT | Provided are methods of making a liquid and liquid vapor-proof material, and relates long-term implantable electronic devices. The method comprisies providing a first substrate having a first-side encapsulating layer supported by at least a portion of the first substrate; providing a material onto the first-side encapsulating layer; providing a second substrate having a second-side encapsulating layer supported by at least a portion of the second substrate; covering an exposed surface of the material provided onto the first-side encapsulation layer with the second-side encapsulating layer; wherein said encapsulating layers are substantially defect free so that liquid or liquid vapor is prevented from passing through each of the encapsulating layers; thereby making the liquid or liquid vapor-proof material. |
| FILED | Wednesday, November 30, 2022 |
| APPL NO | 18/072035 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/031 (20130101) A61B 5/283 (20210101) Original (OR) Class A61B 5/361 (20210101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0587 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/414 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/02115 (20130101) H01L 21/02118 (20130101) H01L 21/02164 (20130101) H01L 21/02167 (20130101) H01L 21/02178 (20130101) H01L 21/02181 (20130101) H01L 21/02258 (20130101) H01L 21/02271 (20130101) H01L 21/02282 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230103798 | Slocik et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| INVENTOR(S) | Joseph M. Slocik (Dayton, Ohio); Rajesh R. Naik (Centerville, Ohio); Patrick B. Dennis (Cincinnati, Ohio) |
| ABSTRACT | A method for modifying the properties of balsa wood comprises infiltrating a protein ionic liquid comprising polymerized dopamine into delignified balsa wood. A method of making an optically active protective coating comprises mixing protein ionic liquid comprising polymerized dopamine with ethyl acetate-based or water-based nail polish. A method of making a thermoplastic having biological activity comprises melting a thermoplastic; and blending a protein ionic liquid with the thermoplastic; and cooling the thermoplastic protein ionic liquid blend to a solid state. The thermoplastic is a hot glue stick. The protein ionic liquid comprises antibodies, enzymes, or fluorescent proteins. A method of making a chymotrypsin protein ionic liquid/thermoplastic material comprises mixing cationized chymotrypsin and anions of poly(ethylene glycol) 4-nonylphenyl 3-sulfopropyl ether to form a chymotrypsin and anion complex; lyophilizing and melting the cationized chymotrypsin and anion complex to form a water-free ionic liquid; blending the chymotrypsin ionic liquid with molten hot glue/thermoplastic. |
| FILED | Friday, October 01, 2021 |
| APPL NO | 17/491579 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/091 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230103909 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jin Chen (San Francisco, California); Luke Gilbert (San Francisco, California); James Nunez (San Francisco, California); Jonathan Weissman (San Francisco, California) |
| ABSTRACT | Provided herein are, inter alia, compositions and methods for manipulation of genomes of living organisms. |
| FILED | Thursday, April 21, 2022 |
| APPL NO | 17/726290 |
| CURRENT CPC | Peptides C07K 14/4702 (20130101) C07K 2319/09 (20130101) C07K 2319/33 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/20 (20130101) C12N 9/1007 (20130101) C12N 15/62 (20130101) Original (OR) Class C12N 15/113 (20130101) Enzymes C12Y 201/01072 (20130101) C12Y 301/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230103984 | Gin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado); The Trustees Of The University Of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Douglas L. Gin (Longmont, Colorado); Patrick Li (Broomfield, Colorado); Chinedum Osuji (Gladwyne, Pennsylvania); Omar Imran (Philadelphia, Pennsylvania); Christopher Johnson (Philadelphia, Pennsylvania); Samantha S. Dyer (Boulder, Colorado) |
| ABSTRACT | The present disclosure relates, in part, to compositions comprising the compound of Formula (I), and polymerized compositions thereof. In certain embodiments, the compositions further comprise at least one compound of Formula (IIa) and Formula (IIb). In another aspect, the present disclosure relates to methods of preparation of the polymer compositions of the present disclosure, the method comprising contacting the compound of Formula (I) and a photoinitiator in the presence of a solvent to form a gyroid mesophase gel and irradiating the gyroid mesophase gel with UV light. In certain embodiments, the contacting further comprises at least one compound of Formula (IIa) and Formula (IIb). |
| FILED | Tuesday, September 20, 2022 |
| APPL NO | 17/949072 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 233/38 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 36/22 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230104050 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SRI International (Menlo Park, California) |
| ASSIGNEE(S) | SRI International (Menlo Park, California) |
| INVENTOR(S) | Denong Wang (Palo Alto, California); Lisa Wu (San Francisco, California) |
| ABSTRACT | Example methods comprise administering an immunogenic vaccine composition to a subject, the immunogenic vaccine composition comprising a glycoconjugate. The method can further comprise, in response to the administration of the immunogenic vaccine composition, inducing production of anti-oligomannose antibodies in the subject and thereby eliciting an immune response to a viral pathogen in the subject. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/907313 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 47/56 (20170801) Original (OR) Class A61K 2039/58 (20130101) Peptides C07K 16/44 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6854 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230104171 | Rodrigues et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kristen Alexandra Rodrigues (Cumberland, Rhode Island); Sergio A. Rodriguez Aponte (Cambridge, Massachusetts); Neil Dalvie (Cambridge, Massachusetts); Darrell Irvine (Arlington, Massachusetts); J. Christopher Love (Somerville, Massachusetts) |
| ABSTRACT | Compositions are disclosed that include alum and a SARS-CoV-2 Spike (S) glycoprotein variant covalently bound to the alum via at least one linker having 2-12 phosphoserine residues, where the S glycoprotein variant includes a receptor binding domain (RBD) having a mutation of at least one amino acid residue in an angiotensin-converting enzyme 2 (ACE2) receptor binding motif (RBM) relative to a wild-type RBD, where the residue is (i) hydrophobic; and (ii) within an aggregation-prone region of about 3-15 amino acid residues, and the mutation is a substitution of the hydrophobic residue with a different amino acid residue; as are compositions and vaccines including the compositions, and methods for their use. |
| FILED | Friday, July 29, 2022 |
| APPL NO | 17/816061 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/51 (20130101) A61K 39/215 (20130101) Original (OR) Class A61K 2039/55505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/165 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230104649 | Wells et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tabitha Wells (Waddell, Arizona); Christopher Pillsbury (Lancaster, California) |
| ABSTRACT | Various embodiments comprise systems, mechanisms, and apparatus configured to enable off-platform presentation of a cable assembly for prior to platform installation of the cable assembly. An apparatus according to one embodiment comprises: an elongated and substantially planar body having a first surface disposed between proximal and distal ends of the body and configured to receive thereupon the cable assembly, the first surface having formed therethrough a plurality of apertures arranged in accordance with a spacing of cable connections of the cable assembly; and a retention assembly, configured to secure the cable assembly to the first surface in a manner allowing mechanical manipulation of the cable assembly; wherein the cable assembly is configured for platform installation when secured to the first surface such that cable connections and corresponding apertures are operatively aligned. |
| FILED | Saturday, October 01, 2022 |
| APPL NO | 17/958325 |
| CURRENT CPC | Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors H01R 43/28 (20130101) Original (OR) Class Installation of Electric Cables or Lines, or of Combined Optical and Electric Cables or Lines H02G 3/0487 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230105074 | Landry et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Blake J. Landry (Saint Martinville, Louisiana); Charles R. Key (Diamondhead, Mississippi); Edward F. Braithwaite, III (Covington, Louisiana) |
| ABSTRACT | A central payload manager device may include a network switch, a central payload manager processing device, a plurality of connecting interfaces, a plurality of sensor processing devices connected to corresponding ones of the connecting interfaces and to the network switch, a cell modem or radio link connected to one or more of the connecting interfaces and to the network switch, a data storage device connected to the processing device, wherein the data storage device is configured to receive and store infoimation from the plurality of sensor processing devices and from the cell modem or radio link via the network switch and the central payload manager processing device; and an iridium modern connecting to the central payload manager processing device and to a corresponding one of the connecting interfaces, wherein the iridium modem is configured to receive and transmit the stored information from the data storage device to an iridium antenna. |
| FILED | Thursday, October 06, 2022 |
| APPL NO | 17/961530 |
| CURRENT CPC | Offensive or Defensive Arrangements on Vessels; Mine-laying; Mine-sweeping; Submarines; Aircraft Carriers B63G 8/38 (20130101) Electric Digital Data Processing G06F 13/20 (20130101) Original (OR) Class G06F 2213/40 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 12/40013 (20130101) H04L 2012/40273 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230105528 | Wehner et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Stratom, Inc. (Boulder, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ross Wehner (Bouulder, Colorado); Ryan Marsini (Frederick, Colorado); Ryan Delgizzi (Arvada, Colorado); Mark Gordon (Lafayette, Colorado); Jesse Weifenbach (Thornton, Colorado); David Regan (Arvada, Colorado) |
| ABSTRACT | A cargo transport system is provided that has an ability to move cargo in an autonomous or semi-autonomous manner, using a compact lift vehicle capable of lifting relatively heavy objects. The system includes a cargo loading system, a sensor suite coupled with a controller, dunnage detection, cross-decking capability, cargo stacking capability, autonomous navigation, tip detection and prevention, or any combinations thereof. The system may include a fork assembly coupled with a mast and movable in a vertical direction relative to the mast. Further, the mast may be coupled with a platform or deck and movable in a horizontal direction relative to the platform, to allow the fork assembly to be lowered below a top plane of the platform when the mast is at a forward location relative to the platform. The controller and sensor suite and may provide for autonomous or semi-autonomous control and movement of the cargo transport system. |
| FILED | Tuesday, December 06, 2022 |
| APPL NO | 18/075614 |
| CURRENT CPC | Vehicles Adapted for Load Transportation or to Transport, to Carry, or to Comprise Special Loads or Objects B60P 1/36 (20130101) Original (OR) Class Servicing, Cleaning, Repairing, Supporting, Lifting, or Manoeuvring of Vehicles, Not Otherwise Provided for B60S 9/10 (20130101) Motor Vehicles; Trailers B62D 55/065 (20130101) Hoisting, Lifting, Hauling or Pushing, Not Otherwise Provided For, e.g Devices Which Apply a Lifting or Pushing Force Directly to the Surface of a Load B66F 9/063 (20130101) B66F 9/195 (20130101) B66F 9/07559 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230105578 | Susca et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina) |
| ASSIGNEE(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina) |
| INVENTOR(S) | Ryan Susca (Windsor, Connecticut); Morgan O'Rorke (West Hartford, Connecticut); Ryan Shook (Rockford, Illinois); Matej Rutar (Manchester, Connecticut) |
| ABSTRACT | A variable positive displacement pump actuator system for a variable positive displacement pump can include a supply line configured to provide a supply pressure, a main pump line configured to provide a pump pressure greater than the supply pressure from the variable positive displacement pump, and at least one electro-hydraulic servo valve (EHSV) in fluid communication with the supply line and the main pump line to receive the supply pressure and the pump pressure. The at least one electro-hydraulic servo valve can be configured to output a first regulated pressure and a second regulated pressure. The system can include a first control line in fluid communication with at least one of the at least one EHSV to receive the first controlled pressure, a second control line in fluid communication with at least one of the at least one EHSV to receive the second controlled pressure, a first hydraulic actuator configured to connect to and/or otherwise actuate a lever arm of the variable positive displacement pump, the first hydraulic actuator in fluid communication with the first control line and the supply line to receive the first control pressure and the supply pressure to control a position of the first hydraulic actuator, and a second hydraulic actuator configured to connect to and/or otherwise actuate the lever arm of the variable positive displacement pump, the second hydraulic actuator in fluid communication with the second control line and the supply line to receive the second control pressure and the supply pressure to control a position of the second hydraulic actuator. |
| FILED | Monday, October 04, 2021 |
| APPL NO | 17/493390 |
| CURRENT CPC | Positive-displacement Machines for Liquids; Pumps F04B 1/29 (20130101) F04B 1/32 (20130101) Original (OR) Class F04B 1/34 (20130101) F04B 1/143 (20130101) F04B 49/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230105656 | Benedick |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Andrew Benedick (Stow, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Benedick (Stow, Massachusetts) |
| ABSTRACT | Binary-phase-shift-key, phase-modulated waveforms with gigahertz bandwidths, suitable for kilowatt-class fiber amplifiers, can be narrowed back to the source laser’s linewidth via second-harmonic, sum-frequency, or difference-frequency generation in a second-order nonlinear crystal. The spectrum of an optical signal phase-modulated with a pseudo-random bit sequence (PRBS) waveform recovers its original optical spectrum when frequency-doubled using second-harmonic generation (SHG). Conceptually, the PRBS waveform is cancelled by the SHG process, and the underlying laser spectrum is converted to the second-harmonic wavelength as though the PRBS modulation were not present. The same cancellation is possible with sum-frequency generation (SFG) and difference frequency generation (DFG), making it possible to construct high-power, narrow-linewidth lasers at wavelengths from the visible to the long-wave infrared. Using ytterbium-, erbium-, thulium-, and neodymium-doped fibers with SHG, SFG and DFG processes allows generation of high-power beams with very narrowband optical spectra and wavelengths from below 400 nm to beyond 5 µm. |
| FILED | Friday, August 05, 2022 |
| APPL NO | 17/817859 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 19/04 (20130101) G01S 19/44 (20130101) Original (OR) Class G01S 19/46 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230105776 | LaBARBERA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, A body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel V. LaBARBERA (Aurora, Colorado); Qiong ZHOU (Aurora, Colorado); Adedoyin D. ABRAHAM (Aurora, Colorado) |
| ABSTRACT | A compound, or a pharmaceutically acceptable salt, solvate or prodrug thereof, having the chemical structure of formula I as defined in the text and methods of using these compounds to inhibit topoisomerase IIα and treat or prevent metastasis of cancer in a subject. |
| FILED | Wednesday, April 01, 2020 |
| APPL NO | 17/599193 |
| CURRENT CPC | Heterocyclic Compounds C07D 215/14 (20130101) Original (OR) Class C07D 401/12 (20130101) C07D 405/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230105874 | Gemar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Heath Gemar (Washington, District of Columbia); Michael K. Yetzbacher (Burke, Virginia) |
| ABSTRACT | A technique is provided for weakly coupling an absorber to a plasmonic device by placing an isolation layer in between them. This technique enables the spectral selective nature of a plasmonic device to be used in conjunction with an absorber. This technique optimizes the trade-off of near-field coupling and spectral selectivity to allow for deep sub-pixel examination of a scene, and is thus suited for multispectral imagers, among other applications. |
| FILED | Friday, September 23, 2022 |
| APPL NO | 17/935083 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/554 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230106114 | UNWALLA et al. |
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| FUNDED BY |
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| APPLICANT(S) | HOSHANG JEHANGIR UNWALLA (MIAMI, Florida); SRINIVASAN CHINNAPAIYAN (MIAMI, Florida) |
| ASSIGNEE(S) | The Florida International University Board of Trustees (Miami, Florida) |
| INVENTOR(S) | HOSHANG JEHANGIR UNWALLA (MIAMI, Florida); SRINIVASAN CHINNAPAIYAN (MIAMI, Florida) |
| ABSTRACT | The invention pertains to an inducible CRISPR system for controlling expression of a CRISPR complex with an inducible fusion promoter. One embodiment of the invention provides HIV LTR-minimal Drosophila hsp70 fusion promoter that can be used for inducible co-expression of gRNA and Cas9 in HIV-infected cells to target cellular cofactors such as Cyclin T1. A single introduction of such embodiment leads to sustained suppression of HIV replication in stringent, chronically infected HeLa-CD4 cell lines as well as in T-cell lines. In another embodiment, the invention further relates to enhancement of HIV suppression by incorporating cis-acting ribozymes immediately upstream of the gRNA in the inducible CRISPR system construct. The inducible fusion promoter is adaptable for other tissue- or cell-type specific expression of the inducible CRISPR system. |
| FILED | Friday, October 01, 2021 |
| APPL NO | 17/491738 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2830/002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230106126 | Wehner et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Stratom, Inc. (Boulder, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ross Wehner (Boulder, Colorado); Ryan Marsini (Frederick, Colorado); Ryan Delgizzi (Arvada, Colorado); Mark Gordon (Lafayette, Colorado); Jesse Weifenbach (Thornton, Colorado); David Regan (Arvada, Colorado) |
| ABSTRACT | A cargo transport system is provided that has an ability to move cargo in an autonomous or semi-autonomous manner, using a compact lift vehicle capable of lifting relatively heavy objects. The system includes a cargo loading system, a sensor suite coupled with a controller, dunnage detection, cross-decking capability, cargo stacking capability, autonomous navigation, tip detection and prevention, or any combinations thereof. The system may include a fork assembly coupled with a mast and movable in a vertical direction relative to the mast. Further, the mast may be coupled with a platform or deck and movable in a horizontal direction relative to the platform, to allow the fork assembly to be lowered below a top plane of the platform when the mast is at a forward location relative to the platform. The controller and sensor suite and may provide for autonomous or semi-autonomous control and movement of the cargo transport system. |
| FILED | Tuesday, December 06, 2022 |
| APPL NO | 18/075616 |
| CURRENT CPC | Vehicles Adapted for Load Transportation or to Transport, to Carry, or to Comprise Special Loads or Objects B60P 1/36 (20130101) Original (OR) Class Servicing, Cleaning, Repairing, Supporting, Lifting, or Manoeuvring of Vehicles, Not Otherwise Provided for B60S 9/10 (20130101) Motor Vehicles; Trailers B62D 55/065 (20130101) Hoisting, Lifting, Hauling or Pushing, Not Otherwise Provided For, e.g Devices Which Apply a Lifting or Pushing Force Directly to the Surface of a Load B66F 9/063 (20130101) B66F 9/195 (20130101) B66F 9/07559 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230106783 | Bixel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tyler W Bixel (Beavercreek, Ohio); Hiroyuki Kosai (Beavercreek, Ohio); James D. Scofield (Whittier, North Carolina) |
| ABSTRACT | The present invention relates high power flux cancelling current steering inductor without a gap and processes of making and using same. When properly configured and wired such inductors, separate the AC component and DC component of a high power current thus allowing the smaller AC fraction of the overall current to be carried by much smaller cross-sectional litz wires. Such high power flux cancelling current steering inductor without a gap are more efficient at avoiding core saturation compared to standard inductors, do not require core gaps, yet they are less expensive without the need for large cross-sectional litz AC carrying wires. In addition to the aforementioned benefits, such high power flux cancelling current steering inductor without a gap permits the levels of AC and DC current to be efficiently monitored as such currents are separated. |
| FILED | Wednesday, September 07, 2022 |
| APPL NO | 17/939086 |
| CURRENT CPC | Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 3/10 (20130101) H01F 27/34 (20130101) Original (OR) Class H01F 27/306 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230106799 | Venkatasubramanian et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rama Venkatasubramanian (Cary, North Carolina); Luke E. Osborn (Baltimore, Maryland); Robert S. Armiger (Catonsville, Maryland); Meiyong Himmtann (Sykesville, Maryland); Jonathan M. Pierce (North Eldersburg, Maryland) |
| ABSTRACT | A thermotactile stimulation prosthesis includes a prosthesis extremity having a prosthesis interface configured for attachment to a human limb, and a thermoelectric actuator array coupled to the prosthesis interface and configured to establish a noninvasive thermoneural human-machine interface capable of providing sensations of temperature to the human limb. |
| FILED | Wednesday, November 30, 2022 |
| APPL NO | 18/071789 |
| CURRENT CPC | Refrigeration Machines, Plants or Systems; Combined Heating and Refrigeration Systems; Heat-pump Systems F25B 21/02 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/16 (20130101) H01L 35/16 (20130101) H01L 35/30 (20130101) Original (OR) Class H01L 35/325 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230107007 | LU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland); Government of the United States of America, as Represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiyuan LU (Montgomery Village, Maryland); Kartik SRINIVASAN (Rockville, Maryland) |
| ABSTRACT | A system for generating a coherent laser light includes a light source configured to pump a first color laser light and a device configured to generate a coherent second color light and a coherent third color light. The device includes a waveguide configured to couple to the light source and a microring resonator coupled to the light source via the waveguide. The microring resonator is configured to generate a coherent second color light and a coherent third color light. The generation of the coherent second color light and the coherent third color light is based on hybrid-mode optical parametric oscillation. |
| FILED | Tuesday, October 04, 2022 |
| APPL NO | 17/959538 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/392 (20210101) G02F 1/395 (20130101) G02F 1/3544 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/063 (20130101) H01S 3/0627 (20130101) H01S 3/1083 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230107105 | Brewer |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tony Brewer (Plano, Texas) |
| ABSTRACT | Devices and techniques for managing hazards in a memory controller are described herein. The memory controller can receive a memory request that includes a base memory address. An index can be computed from the base memory address and a lookup, using the index, can be performed to find a lock. When the lock is found, the memory controller can store the memory request in a buffer that corresponds to the lock. In response to a signal to clear the lock, the memory controller removes the memory request from the buffer and performs the memory request. |
| FILED | Monday, December 05, 2022 |
| APPL NO | 18/075111 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/0613 (20130101) G06F 3/0631 (20130101) G06F 3/0673 (20130101) G06F 12/0862 (20130101) G06F 13/1642 (20130101) G06F 13/1668 (20130101) G06F 13/1673 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230107239 | Iacono et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott T. Iacono (Colorado Springs, Colorado); Chadron M. Friesen (Langley, Canada) |
| ABSTRACT | The present invention relates to a mechanochemical based synthesis of perfluoropyridine monomers, polymers made using such monomers and methods of making and using articles comprising such polymers. Such perfluoropyridine monomers are easily chemically tuned have the strength needed for high temperature applications and the flexibility needed for low temperature applications. In addition, to the aforementioned monomers, a mechanochemical based synthesis for such perfluoropyridine monomers is provided. All of the aforementioned performance application advantages are also found in polymers comprising Applicants' perfluoropyridine monomers. |
| FILED | Monday, October 04, 2021 |
| APPL NO | 17/493024 |
| CURRENT CPC | Heterocyclic Compounds C07D 213/61 (20130101) Original (OR) Class Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 73/0627 (20130101) Cracking Hydrocarbon Oils; Production of Liquid Hydrocarbon Mixtures, e.g by Destructive Hydrogenation, Oligomerisation, Polymerisation; Recovery of Hydrocarbon Oils From Oil-shale, Oil-sand, or Gases; Refining Mixtures Mainly Consisting of Hydrocarbons; Reforming of Naphtha; Mineral Waxes C10G 71/00 (20130101) Lubricating Compositions; Use of Chemical Substances Either Alone or as Lubricating Ingredients in a Lubricating Composition C10M 147/04 (20130101) C10M 169/041 (20130101) C10M 2203/003 (20130101) C10M 2213/06 (20130101) Indexing Scheme Associated With Subclass C10M Relating to Lubricating Compositions C10N 2050/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230107256 | Watowich et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of the University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stanley Watowich (Galveston, Texas); Harshini Neelakantan (Galveston, Texas); Hua-Yu Wang (Galveston, Texas); Stanton Mchardy (Galveston, Texas) |
| ABSTRACT | The present invention relates to quinoline derived small molecule inhibitors of nicotinamide N-methyltransferase (NNMT), the preparation thereof and uses thereof. |
| FILED | Tuesday, June 07, 2022 |
| APPL NO | 17/834847 |
| CURRENT CPC | Heterocyclic Compounds C07D 215/10 (20130101) C07D 215/26 (20130101) C07D 215/42 (20130101) Original (OR) Class C07D 405/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230107506 | Shan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Junyi Shan (Pasadena, California); Mengxing Ye (Santa Barbara, California); Leon Balents (Santa Barbara, California); David Hsieh (San Marino, California) |
| ABSTRACT | A control circuit for controlling a timing, a pulse length, a valve electric field having the certain magnitude, and a pulse envelope of the valve electric field, so as to coherently control a response of a region of an insulator to a probe electric field, the response controlled with a temporal resolution equal to the pulse length and matching the pulse envelope. |
| FILED | Thursday, September 08, 2022 |
| APPL NO | 17/940661 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 29/0885 (20130101) Original (OR) Class Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/0081 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230107647 | MARCOTTE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| INVENTOR(S) | Edward MARCOTTE (Austin, Texas); Eric V. ANSLYN (Austin, Texas); Andrew ELLINGTON (Austin, Texas); Jagannath SWAMINATHAN (Austin, Texas) |
| ABSTRACT | Identifying proteins and peptides, and more specifically large-scale sequencing of single peptides in a mixture of diverse peptides at the single molecule level is an unmet challenge in the field of protein sequencing. Herein are methods for identifying amino acids in peptides, including peptides comprising unnatural amino acids. In one embodiment, the N-terminal amino acid is labeled with a first label and an internal amino acid is labeled with a second label. In some embodiments, the labels are fluorescent labels. In other embodiments, the internal amino acid is Lysine. In other embodiments, amino acids in peptides are identified based on the fluorescent signature for each peptide at the single molecule level. |
| FILED | Thursday, July 07, 2022 |
| APPL NO | 17/811284 |
| CURRENT CPC | Peptides C07K 17/08 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/58 (20130101) G01N 33/582 (20130101) G01N 33/6818 (20130101) G01N 33/6824 (20130101) Original (OR) Class G01N 2570/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230108395 | Reddinger |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | U.S. Army DEVCOM, Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jean-Paul Francis Reddinger (Baltimore, Maryland) |
| ABSTRACT | A rotor system comprising a hinge coupled between a rotor blade and a hub, where the hinge comprises a pivot that is angled relative to a rotor axis of rotation to enable pitch of the rotor blade to change when the rotor blade experiences lag. |
| FILED | Friday, October 01, 2021 |
| APPL NO | 17/491740 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 27/51 (20130101) B64C 27/57 (20130101) Original (OR) Class Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 27/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230108485 | Keolian et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert M. Keolian (State College, Pennsylvania); Kevin J. Bastyr (Franklin, Michigan); Ray Scott Wakeland (Marlborough, Massachusetts); John Feurman Brady (Madison, Alabama) |
| ABSTRACT | A heat exchanger with a monocoque structure transfers heat between a first fluid and a second fluid. The heat exchanger has a plurality of tubes through which the first fluid may flow in a direction, each of the plurality of tubes has a first mouth end, an opposing second mouth end and a waist region between the first mouth end and the second mouth end. The heat exchanger also has one or more intercomlected fluid challllels through which the second fluid may flow. the one or more fluid chamlels lay generally in a plane, the plurality of tubes and the one or more fluid channels interleave such that heat may be transferred between the plurality of tubes and the one or more fluid challllels, and the direction of flow of the first fluid is generally perpendicular to the plane of the one or more fluid chamlels. |
| FILED | Thursday, December 08, 2022 |
| APPL NO | 18/077939 |
| CURRENT CPC | Hot Gas or Combustion-product Positive-displacement Engine Plants; Use of Waste Heat of Combustion Engines; Not Otherwise Provided for F02G 1/055 (20130101) Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 7/163 (20130101) Original (OR) Class F28D 2021/0026 (20130101) Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 1/025 (20130101) F28F 1/44 (20130101) F28F 13/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230108618 | DENHAM et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Aerospace Corporation (El Segundo, California) |
| ASSIGNEE(S) | The Aerospace Corporation (El Segundo, California) |
| INVENTOR(S) | Donald Wayne DENHAM (Redondo Beach, California); Timothy P. WOODARD (League City, Texas) |
| ABSTRACT | A payload-bus kinematic interface system includes one or more kinematic devices. Each kinematic device includes a first contacting surface and a second contacting surface. The first contacting surface kinematically interfaces with the second contacting surface, passing loads or forces to the second contacting surface. |
| FILED | Monday, October 04, 2021 |
| APPL NO | 17/492887 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/428 (20130101) B64G 1/641 (20130101) Original (OR) Class Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 7/206 (20130101) H01F 7/0231 (20130101) H01F 2007/208 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230108651 | NESTLER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Analog Devices, Inc. (Wilmington, Massachusetts) |
| ASSIGNEE(S) | Analog Devices, Inc. (Wilmington, Massachusetts) |
| INVENTOR(S) | Eric G. NESTLER (Beach Haven, New Jersey); Naveen VERMA (Princeton, New Jersey); Hossein VALAVI (Princeton, New Jersey) |
| ABSTRACT | Systems and methods are provided for reducing power in in-memory computing, matrix-vector computations, and neural networks. An apparatus for in-memory computing using charge-domain circuit operation includes transistors configured as memory bit cells, transistors configured to perform in-memory computing using the memory bit cells, capacitors configured to store a result of in-memory computing from the memory bit cells, and switches, wherein, based on a setting of each of the switches, the charges on at least a portion of the plurality of capacitors are shorted together. Shorting together the plurality of capacitors yields a computation result. |
| FILED | Friday, February 18, 2022 |
| APPL NO | 17/675617 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/061 (20130101) G06N 3/0454 (20130101) G06N 3/0481 (20130101) G06N 3/0635 (20130101) Original (OR) Class Static Stores G11C 11/54 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230108715 | Kendall-Bar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Jessica Kendall-Bar (Santa Cruz, California); Terrie Williams (Santa Cruz, California); Patricio Guerrero (Santa Cruz, California); Ethan Slattery (Santa Cruz, California); Daniel P. Costa (Santa Cruz, California) |
| ABSTRACT | A water resistant biometric data logging system for an animal including a housing containing an electrophysiological data logging device and an underwater connector configured to route and waterproof at least 10 electrode cables to the electrophysiological data logging device. Further disclosed is an apparatus (e.g., headcap) for mounting electrodes onto the animal. The apparatus includes a first layer comprising a first plurality of openings or holes, the first layer comprising a foam or a sacrificial material; a second layer comprising a second plurality of openings or holes, the second layer comprising or consisting essentially of synthetic rubber; and a potted piece containing a plurality of electrode cables, wherein the electrode cables are routed from the potted piece through the first plurality of openings and the second plurality of openings or holes. |
| FILED | Monday, October 03, 2022 |
| APPL NO | 17/959146 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/333 (20210101) A61B 5/367 (20210101) A61B 5/4806 (20130101) Original (OR) Class A61B 2503/40 (20130101) A61B 2562/182 (20130101) A61B 2562/222 (20130101) A61B 2562/225 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230108742 | Cao |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Connecticut (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yang Cao (Glastonbury, Connecticut) |
| ABSTRACT | An insulating composition comprising a polymer resin, a nanoclay, and one or more nanofillers. The insulating composition has a thermal conductivity of greater than about 0.8 W/mK, a dielectric constant of less than about 5, a dissipation factor of less than about 3%, and a breakdown strength of greater than about 1,000 V/mil. The insulating composition has an endurance life of at least 400 hours at 310 volts per mil. |
| FILED | Friday, December 09, 2022 |
| APPL NO | 18/078300 |
| CURRENT CPC | Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 3/426 (20130101) Dynamo-electric Machines H02K 3/30 (20130101) Original (OR) Class H02K 3/50 (20130101) H02K 15/12 (20130101) H02K 15/105 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230109070 | Richman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees og the Leland Standford Junior University (Standford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ethan B. Richman (Woodside, California); William E. Allen (Albany, California); Karl A. Deisseroth (Stanford, California) |
| ABSTRACT | Provided herein are devices, methods, and systems for in situ gene sequencing of a target nucleic acid in a cell in an intact tissue. Methods of screening a candidate agent to determine whether the candidate agent modulates gene expression of a nucleic acid in a cell in an intact tissue are also provided herein. |
| FILED | Thursday, October 15, 2020 |
| APPL NO | 17/768996 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50851 (20130101) B01L 7/52 (20130101) B01L 2200/026 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6841 (20130101) C12Q 1/6869 (20130101) Original (OR) Class C12Q 2521/501 (20130101) C12Q 2531/125 (20130101) C12Q 2535/125 (20130101) C12Q 2563/107 (20130101) C12Q 2563/179 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230109259 | Slocik et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| INVENTOR(S) | Joseph M. Slocik (Dayton, Ohio); Rajesh R. Naik (Centerville, Ohio); Patrick B. Dennis (Cincinnati, Ohio) |
| ABSTRACT | A method for modifying the properties of balsa wood comprises infiltrating a protein ionic liquid comprising polymerized dopamine into delignified balsa wood. A method of making an optically active protective coating comprises mixing protein ionic liquid comprising polymerized dopamine with ethyl acetate-based or water-based nail polish. A method of making a thermoplastic having biological activity comprises melting a thermoplastic; and blending a protein ionic liquid with the thermoplastic; and cooling the thermoplastic protein ionic liquid blend to a solid state. The thermoplastic is a hot glue stick. The protein ionic liquid comprises antibodies, enzymes, or fluorescent proteins. A method of making a chymotrypsin protein ionic liquid/thermoplastic material comprises mixing cationized chymotrypsin and anions of poly(ethylene glycol) 4-nonylphenyl 3-sulfopropyl ether to form a chymotrypsin and anion complex; lyophilizing and melting the cationized chymotrypsin and anion complex to form a water-free ionic liquid; blending the chymotrypsin ionic liquid with molten hot glue/thermoplastic. |
| FILED | Friday, October 01, 2021 |
| APPL NO | 17/491592 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/091 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230109355 | Araromi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Oluwaseun A. Araromi (Cambridge, Massachusetts); Conor J. Walsh (Cambridge, Massachusetts); Robert J. Wood (Cambridge, Massachusetts) |
| ABSTRACT | A strain sensor comprising a conductive member having a plurality of elements arranged adjacent to one another, and a non-conductive and elastically deformable material encapsulating the conductive member, wherein, in an equilibrium state, compressive forces cause at least one of the plurality of elements to contact at least a portion of an adjacent element, and wherein, when a strain is applied, a resulting elastic deformation causes at least one of the plurality of elements to space apart from an adjacent element such that the contacted portion decreases or is eliminated. A multi-axis force sensor comprising a sensing array comprising at least two planar sensors arranged radially on a planar substrate in antagonistic pairs, and a compressible member positioned between the substrate and a central portion of the sensing array, the compressible member acting to displace the central portion of the sensing array away from the substrate. |
| FILED | Friday, July 08, 2022 |
| APPL NO | 17/860235 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 7/18 (20130101) Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/2287 (20130101) Original (OR) Class G01L 5/1627 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20230103603 | Fushimi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rebecca R. Fushimi (Idaho Falls, Idaho); Zongtang Fang (Idaho Falls, Idaho); Grigoriy Yablonsky (St. Louis, Missouri) |
| ABSTRACT | A catalyst structure is disclosed. The catalyst structure comprises a catalytic material and a metal material on the catalytic material, where the metal material comprises particle sizes in a range from about 1.5 nanometers to about 3 nanometers. An interface between the metal material and the catalytic material comprises bonds between the metal material and the catalytic material. A method of mitigating catalyst deactivation is also disclosed, as is a method of carbon monoxide disproportionation. |
| FILED | Friday, December 02, 2022 |
| APPL NO | 18/061235 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/6525 (20130101) B01J 27/22 (20130101) Original (OR) Class B01J 27/28 (20130101) B01J 35/023 (20130101) B01J 37/0221 (20130101) B01J 38/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230103857 | Xie |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Indiana University (Bloomington, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jian Xie (Zionsville, Indiana) |
| ABSTRACT | Solid electrolyte interphase (SEI) preformed graphite, methods of forming SEI preformed graphite, apparatus for forming SEI preformed graphite, and electrochemical battery cells including an SEI preformed graphite electrode. A method of making SEI preformed graphite includes forming an SEI coating on individual graphite particles in a suspension of graphite particles in an electrolyte by generating a voltage between a cathode and an anode having a lithium source across the suspension. An SEI preformed graphite includes a graphite powder having a preformed SEI layer on each of a plurality of graphite particles in powder form. The SEI layer covers the exterior surface of each of the graphite particle in the graphite powder. An electrochemical battery cell may be formed using the SEI preformed graphite. A flow cell apparatus is provided for forming the SEI preformed graphite. |
| FILED | Friday, September 30, 2022 |
| APPL NO | 17/937136 |
| CURRENT CPC | Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 5/54 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/133 (20130101) H01M 4/0452 (20130101) Original (OR) Class H01M 4/625 (20130101) H01M 2004/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230105323 | English et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Florida State University Research Foundation, Inc. (Tallahassee, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles Lamar English (Tallahassee, Florida); George Miller (Tallahassee, Florida); Ernesto Bosque (Tallahassee, Florida) |
| ABSTRACT | A furnace system including an outer shell which comprises a top flange, an elongated body portion, and a bottom flange, wherein the outer shell is a pressure vessel, with no penetrations in the elongated body portion; a heater assembly which comprises (i) a single-piece annular shaped insulation layer, and (ii) a plurality of heaters embedded in the insulation layer, wherein the heater assembly is disposed within the elongated body portion of the outer shell; and an innermost layer disposed within the annular-shaped insulation layer, wherein the innermost layer is a baffle tube configured to force a natural convective flow, wherein each of the plurality of heaters is individually controllable and the plurality of heaters are configured to heat different zones within the furnace to different temperatures and/or at different rates. The system may be used to heat treat magnet materials, such as those formed of Bi-2212, therein. |
| FILED | Friday, September 23, 2022 |
| APPL NO | 17/934745 |
| CURRENT CPC | Furnaces, Kilns, Ovens, or Retorts in General; Open Sintering or Like Apparatus F27B 17/0083 (20130101) Original (OR) Class Details or Accessories of Furnaces, Kilns, Ovens, or Retorts, in so Far as They Are of Kinds Occurring in More Than One Kind of Furnace F27D 1/00 (20130101) F27D 7/06 (20130101) F27D 99/0006 (20130101) F27D 2007/063 (20130101) F27D 2019/0009 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 6/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230105880 | Judd et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Triad National Security, LLC (Los Alamos, New Mexico) |
| ASSIGNEE(S) | Triad National Security, LLC (Los Alamos, New Mexico) |
| INVENTOR(S) | Stephen Judd (Los Alamos, New Mexico); David Guenther (Los Alamos, New Mexico); Nicholas Dallmann (Los Alamos, New Mexico); William Raymond Mairson (Los Alamos, New Mexico) |
| ABSTRACT | A tag enhances vehicle radar visibility of objects by increasing the effective radar cross-section of the object, allowing detection at longer ranges and providing the vehicle/driver with more time to avoid a collision. The tag may include a receive antenna and a bandpass filter configured to receive a signal from the receive antenna and to allow a portion of the frequency range of the signal from the receive antenna through. The tag may also include an amplifier configured to receive and amplify the signal with the portion of the frequency range from the bandpass filter. The tag may further include a transmit antenna configured to transmit the amplified signal. The receive antenna, the transmit antenna, and the amplifier may be configured such that antenna-to-antenna isolation between the receive antenna and the transmit antenna is greater than a gain of the amplifier. |
| FILED | Monday, September 19, 2022 |
| APPL NO | 17/933281 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 13/767 (20130101) Original (OR) Class G01S 13/931 (20130101) Antennas, i.e Radio Aerials H01Q 1/525 (20130101) H01Q 1/3233 (20130101) H01Q 9/0407 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230105993 | OZMEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | WEST VIRGINIA UNIVERSITY BOARD (Morgantown, West Virginia); UNITED STATES DEPARTMENT OF ENERGY (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ozcan OZMEN (Hillsboro, Oregon); Shiwoo LEE (Arlington Heights, Illinois); Edward SABOLSKY (Morgantown, West Virginia) |
| ABSTRACT | The present invention provides a process for incorporating at least one nano-catalyst on the surface of and within a plurality of pores of an electrode. The process includes spraying or dripping a catechol based surfactant onto the surface of and within one or more pores of a solid oxide electrochemical cell having an anode electrode and a cathode electrode; spraying or dripping a nano-catalyst solution onto the surface of and within one or more pores of the solid oxide electrochemical cell that has been pretreated with the catechol based surfactant for forming a modified solid oxide electrochemical cell; and firing the modified solid oxide electrochemical cell above a calcination temperature of the nano-catalyst solution for forming a nano-catalyst on the surface and within at least one or more pores of the solid oxide electrochemical cell. |
| FILED | Thursday, January 28, 2021 |
| APPL NO | 17/759822 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/886 (20130101) H01M 4/8605 (20130101) H01M 4/8885 (20130101) H01M 4/9008 (20130101) Original (OR) Class H01M 8/1246 (20130101) H01M 2008/1293 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230106189 | Patra et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Susant Patra (Brentwood, California); Robert J. Deri (Pleasanton, California) |
| ABSTRACT | Thermal management may in some cases improve the optical output of a semiconductor laser diode array. For example, providing gaps such as air gaps, at suitable locations may influence the temperature distribution of laser diodes in a laser diode array and curtail thermal lensing, which may in turn decrease beam divergence and increase delivered power. |
| FILED | Friday, October 01, 2021 |
| APPL NO | 17/449781 |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/02469 (20130101) H01S 5/4031 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230106300 | Zhao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yuji Zhao (Chandler, Arizona); Chen Yang (Tempe, Arizona); Houqiang Fu (Tempe, Arizona); Xuanqi Huang (Tempe, Arizona); Kai Fu (Tempe, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yuji Zhao (Chandler, Arizona); Chen Yang (Tempe, Arizona); Houqiang Fu (Tempe, Arizona); Xuanqi Huang (Tempe, Arizona); Kai Fu (Tempe, Arizona) |
| ABSTRACT | Fabricating a vertical-channel junction field-effect transistor includes forming an unintentionally doped GaN layer on a bulk GaN layer by metalorganic chemical vapor deposition, forming a Cr/SiO2 hard mask on the unintentionally doped GaN layer, patterning a fin by electron beam lithography, defining the Cr and SiO2 hard masks by reactive ion etching, improving a regrowth surface with inductively coupled plasma etching, removing hard mask residuals, regrowing a p-GaN layer, selectively etching the p-GaN layer, forming gate electrodes by electron beam evaporation, and forming source and drain electrodes by electron beam evaporation. The resulting vertical-channel junction field-effect transistor includes a doped GaN layer, an unintentionally doped GaN layer on the doped GaN layer, and a p-GaN regrowth layer on the unintentionally doped GaN layer. Portions of the p-GaN regrowth layer are separated by a vertical channel of the unintentionally doped GaN layer. |
| FILED | Friday, November 04, 2022 |
| APPL NO | 17/981178 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/3065 (20130101) H01L 21/3081 (20130101) H01L 29/1058 (20130101) H01L 29/2003 (20130101) H01L 29/8083 (20130101) Original (OR) Class H01L 29/66446 (20130101) H01L 29/66909 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230106379 | Carter et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho); University of Idaho (Moscow, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John P. Carter (Idaho Falls, Idaho); Richard Christensen (Idaho Falls, Idaho) |
| ABSTRACT | A flow control device configured to be positioned in a reactor core. The flow control device including a central shaft and at least one blade extending helically from the central shaft. A nuclear reactor and related systems and methods are also disclosed. |
| FILED | Wednesday, September 28, 2022 |
| APPL NO | 17/936248 |
| CURRENT CPC | Nuclear Reactors G21C 15/12 (20130101) Original (OR) Class G21C 19/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230106574 | Chandrasekaran et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Swetha Chandrasekaran (Dublin, California); Theodore F. Baumann (Discovery Bay, California); Juergen Biener (San Leandro, California); Patrick Campbell (Oakland, California); James S. Oakdale (Castro Valley, California); Marcus A. Worsley (Hayward, California) |
| ABSTRACT | A method includes acquiring a three-dimensional printed template created using an additive manufacturing technique, infilling the template with an aerogel precursor solution, allowing formation of a sol-gel, and converting the sol-gel to an aerogel. |
| FILED | Wednesday, November 30, 2022 |
| APPL NO | 18/072436 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/0091 (20130101) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 80/00 (20141201) Non-metallic Elements; Compounds Thereof; C01B 13/18 (20130101) C01B 32/05 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230106815 | Roehling et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John D. Roehling (Livermore, California); Michael Bagge-Hansen (San Leandro, California); Hannah V. Eshelman (Dublin, California); Mariana Desireé Reale Batista (Livermore, California); Tien T. Roehling (Tracy, California); Alyssa L. Troksa (Livermore, California) |
| ABSTRACT | A cooling system having an IR transparent foam or aerogel, made from an IR transparent material, and an optomechanical frame that serves to concentrate emitted radiation to the most transparent part sky to improve the net cooling power and serve as a mechanical support to the foam or aerogel. |
| FILED | Monday, September 26, 2022 |
| APPL NO | 17/935396 |
| CURRENT CPC | Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 21/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230107113 | Sonnon et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mission Support and Test Services, LLC (Las Vegas, Nevada) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott B. Sonnon (North Las Vegas, Nevada); Erik A. Stassinos (North Las Vegas, Nevada) |
| ABSTRACT | A nasal device is provided to measure an aspect of gas flowing through a user's nose. The nasal device includes a body having a first interior side and a second, opposing interior side. The body forms a lumen between the first interior side and the second interior side through which the gas flows into and out of the user's nose. The nasal device further includes an emitter coupled to the first interior side and configured to emit emitted energy, a detector coupled to the second interior side and configured to receive detected energy, and a wireless transceiver coupled to the body and configured to transmit data corresponding to at least one of the emitted energy and the detected energy. |
| FILED | Monday, October 03, 2022 |
| APPL NO | 17/958821 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/097 (20130101) A61B 5/0803 (20130101) A61B 5/0833 (20130101) A61B 5/0836 (20130101) A61B 5/6819 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230107163 | Xiang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California); The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Chengxiang Xiang (San Marino, California); Shane Ardo (Irvine, California); Leanna Schulte (Irvine, California); Harry A. Atwater (South Pasadena, California); Zejie Chen (Irvine, California); Anastasiya Bender (Irvine, California); Ibadillah A. Digdaya (Whittier, California) |
| ABSTRACT | Systems and methods of gas-liquid contactors for direct ocean capture and/or direct air capture are described. |
| FILED | Tuesday, September 20, 2022 |
| APPL NO | 17/933828 |
| CURRENT CPC | Separation B01D 69/02 (20130101) B01D 69/08 (20130101) B01D 71/36 (20130101) B01D 2325/10 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 27/06 (20130101) B01J 27/232 (20130101) B01J 31/06 (20130101) B01J 31/26 (20130101) B01J 35/065 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/20 (20130101) Original (OR) Class C02F 1/44 (20130101) C02F 1/66 (20130101) C02F 2101/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230107327 | Dai et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Apple Inc. (Cupertino, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hongli Dai (Los Altos, California); Jongho Jeon (Cupertino, California); Libo Hu (Sunnyvale, California); Mingfu He (, None); Qian Liu (Lemont, Illinois); Zhengcheng Zhang (Lemont, Illinois) |
| ABSTRACT | This disclosure relates generally to battery cells, and more particularly, electrolyte additives for use in lithium ion battery cells. |
| FILED | Thursday, September 22, 2022 |
| APPL NO | 17/950430 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/0404 (20130101) H01M 10/0567 (20130101) Original (OR) Class H01M 10/0568 (20130101) H01M 10/0569 (20130101) H01M 50/46 (20210101) H01M 2300/0028 (20130101) H01M 2300/0051 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230107668 | Hatchett et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVAD (Las Vegas, Nevada) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David W. Hatchett (Las Vegas, Nevada); Cassara J. Higgins (Las Vegas, Nevada) |
| ABSTRACT | Described herein are methods for recovering uranium tetrafluoride (UF4) from uranium hexafluoride (UF6) by directly dissolving UF6 in ionic liquids and recovering UF4, which can be processed to obtain UO2 (s) or uranium metal. |
| FILED | Friday, March 05, 2021 |
| APPL NO | 17/795686 |
| CURRENT CPC | Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 43/003 (20130101) C01G 43/06 (20130101) Original (OR) Class C01G 43/066 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230107986 | Shetty et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ginkgo Bioworks, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Ginkgo Bioworks, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Reshma P. Shetty (Boston, Massachusetts); Curt R. Fischer (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure identifies pathways, mechanisms, systems and methods to confer production of carbon-based products of interest, such as sugars, alcohols, chemicals, amino acids, polymers, fatty acids and their derivatives, hydrocarbons, isoprenoids, and intermediates thereof, in engineered and/or evolved methylotrophs such that these organisms efficiently convert C1 compounds, such as formate, formic acid, formaldehyde or methanol, to organic carbon-based products of interest, and in particular the use of organisms for the commercial production of various carbon-based products of interest. |
| FILED | Friday, September 30, 2022 |
| APPL NO | 17/937009 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 1/36 (20130101) C12N 15/52 (20130101) C12N 15/74 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/16 (20130101) C12P 7/40 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 50/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230108342 | Zhao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | RAYTHEON TECHNOLOGIES COPORATION (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wenping Zhao (Glastonbury, Connecticut); Ellen Y. Sun (South Windsor, Connecticut); John P. Wesson (West Hartford, Connecticut); Paul F. Croteau (Columbia, Connecticut); Andrzej E. Kuczek (Bristol, Connecticut) |
| ABSTRACT | A composite pressure vessel assembly includes a plurality of lobes, each of the lobes having at least one interior wall and at least one curved wall, the plurality of lobes being positioned in a side by side arrangement and extending in a longitudinal direction from a first end to a second end. Also included is a plurality of end caps disposed at the ends of the lobes, wherein the plurality of lobes and end caps are formed of at least one fiber-reinforced polymer. A method of manufacturing a composite pressure vessel assembly is provided. The method includes forming a plurality of lobes consisting of at least one fiber-reinforced polymer. The method also includes forming a main body with the plurality of lobes, the lobes disposed in a side by side arrangement. |
| FILED | Thursday, December 08, 2022 |
| APPL NO | 18/077797 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 63/04 (20130101) B29C 70/305 (20130101) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2031/7156 (20130101) Vessels for Containing or Storing Compressed, Liquefied or Solidified Gases; Fixed-capacity Gas-holders; Filling Vessels With, or Discharging From Vessels, Compressed, Liquefied, or Solidified Gases F17C 1/16 (20130101) Original (OR) Class F17C 2201/056 (20130101) F17C 2201/0152 (20130101) F17C 2203/0604 (20130101) F17C 2203/0617 (20130101) F17C 2203/0619 (20130101) F17C 2203/0636 (20130101) F17C 2203/0663 (20130101) F17C 2209/225 (20130101) F17C 2209/227 (20130101) F17C 2209/232 (20130101) F17C 2209/2109 (20130101) F17C 2221/012 (20130101) F17C 2221/031 (20130101) F17C 2221/033 (20130101) F17C 2221/035 (20130101) F17C 2223/035 (20130101) F17C 2223/0123 (20130101) F17C 2260/018 (20130101) F17C 2270/0168 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230108353 | Dai et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Apple Inc. (Cupertino, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hongli Dai (Los Altos, California); Jongho Jeon (Cupertino, California); Libo Hu (Sunnyvale, California); Mingfu He (Lemont, None); Qian Liu (Lemont, Illinois); Zhengcheng Zhang (Lemont, Illinois) |
| ABSTRACT | This disclosure relates generally to battery cells, and more particularly, electrolyte additives for use in lithium ion battery cells. |
| FILED | Thursday, September 22, 2022 |
| APPL NO | 17/950419 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/0404 (20130101) H01M 10/0525 (20130101) H01M 10/0567 (20130101) Original (OR) Class H01M 10/0568 (20130101) H01M 10/0569 (20130101) H01M 50/46 (20210101) H01M 2300/0028 (20130101) H01M 2300/0051 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230108485 | Keolian et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert M. Keolian (State College, Pennsylvania); Kevin J. Bastyr (Franklin, Michigan); Ray Scott Wakeland (Marlborough, Massachusetts); John Feurman Brady (Madison, Alabama) |
| ABSTRACT | A heat exchanger with a monocoque structure transfers heat between a first fluid and a second fluid. The heat exchanger has a plurality of tubes through which the first fluid may flow in a direction, each of the plurality of tubes has a first mouth end, an opposing second mouth end and a waist region between the first mouth end and the second mouth end. The heat exchanger also has one or more intercomlected fluid challllels through which the second fluid may flow. the one or more fluid chamlels lay generally in a plane, the plurality of tubes and the one or more fluid channels interleave such that heat may be transferred between the plurality of tubes and the one or more fluid challllels, and the direction of flow of the first fluid is generally perpendicular to the plane of the one or more fluid chamlels. |
| FILED | Thursday, December 08, 2022 |
| APPL NO | 18/077939 |
| CURRENT CPC | Hot Gas or Combustion-product Positive-displacement Engine Plants; Use of Waste Heat of Combustion Engines; Not Otherwise Provided for F02G 1/055 (20130101) Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 7/163 (20130101) Original (OR) Class F28D 2021/0026 (20130101) Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 1/025 (20130101) F28F 1/44 (20130101) F28F 13/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230108512 | Erno et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Jason Erno (Clifton Park, New York); William Dwight Gerstler (Niskayuna, New York); Biao Fang (Clifton Park, New York); Laura Cerully Dial (Clifton Park, New York); Voramon Supatarawanich Dheeradhada (Latham, New York); Hendrik Pieter Jacobus de Bock (Clifton Park, New York) |
| ABSTRACT | A thermal structure for management of thermal energy, the thermal structure including: a first wall structure defining a first cavity; a second wall structure defining a second cavity, the second cavity in fluid communication with the first cavity; and a barrier cavity defined at least in-part by the first wall structure and the second wall structure, wherein the barrier cavity is disposed between the first cavity and the second cavity and includes a pressurized barrier fluid therein or is configured to receive the pressurized barrier fluid during operation of the thermal structure. |
| FILED | Tuesday, October 05, 2021 |
| APPL NO | 17/494410 |
| CURRENT CPC | Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 9/0018 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230108561 | Amin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ruhul Amin (Oak Ridge, Tennessee); Ilias Belharouak (Oak Ridge, Tennessee); Anand Vasudevbhai Parejiya (Oak Ridge, Tennessee) |
| ABSTRACT | A method of reviving a lithium-ion battery cell in which dendrites are formed providing a lithium-ion battery cell including a lithium-metal-containing electrolyte and one of a graphite or a lithium-metal-containing anode. Lithium dendrites are formed at an anode/electrolyte interface in the cell and extend into the electrolyte of the cell. The method further includes electrochemically healing the battery cell by actively applying a plurality of continuous low current density galvanostatic charge-discharge cycles to the battery cell. Lithium metal is thusly oxidized from tips of the dendrites thereby causing dissolution of the dendrites. |
| FILED | Wednesday, September 28, 2022 |
| APPL NO | 17/954479 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0525 (20130101) H01M 10/0562 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230108718 | MANTHIRAM et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arumugam MANTHIRAM (Austin, Texas); Wangda LI (Austin, Texas); Steven LEE, III (Austin, Texas) |
| ABSTRACT | Described herein are low or no-cobalt materials useful as electrode active materials in a cathode for lithium or lithium-ion batteries. For example, compositions of matter are described herein, such as electrode active materials that can be incorporated into an electrode, such as a cathode. The disclosed electrode active materials exhibit high specific energy and voltage, and can also exhibit high rate capability and/or long operational lifetime. |
| FILED | Friday, March 26, 2021 |
| APPL NO | 17/787257 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/0404 (20130101) H01M 4/525 (20130101) Original (OR) Class H01M 10/0525 (20130101) H01M 2004/021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230108813 | THACKERAY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Michael M. THACKERAY (Naperville, Illinois); Eungje LEE (Naperville, Illinois); Jason R. CROY (Plainfield, Illinois); Boyu SHI (Willowbrook, Illinois) |
| ABSTRACT | A composite electrode active material is described herein, which comprises two or more electrode active materials blended or structurally-integrated together, in one of the materials is a lithiated spinel selected from the group consisting of (a) a lithiated spinel of formula LiMnxNiyMzO2; wherein M comprises at least one metal cation other than manganese and nickel cations; x+y+z=1; 0<x<1.0; 0<y<1.0; 0≤z≤0.5; and the ratio of x:y is in the range of about 1:2 to about 2:1; and (b) a lithiated spinel of formula LiM1O2, wherein M1 comprises a combination of Mn and Ni transition metal ions in a ratio of Mn to Ni ions of about 2:1 to about 1:1. |
| FILED | Monday, December 05, 2022 |
| APPL NO | 18/075023 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/364 (20130101) Original (OR) Class H01M 4/485 (20130101) H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 10/0525 (20130101) H01M 2004/021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230108944 | Chritton |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell Federal Manufacturing & Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | Honeywell Federal Manufacturing & Technologies, LLC (Kansas City, Missouri) |
| INVENTOR(S) | Audrey Chritton (Kansas City, Missouri) |
| ABSTRACT | A simulation system for use in testing a radar system comprises a coarse delay module, a fine delay module, and a doppler shift module. The coarse delay module is configured to receive a first stream of digital data samples that are sampled from a radar signal at a sample time period or a second stream of digital data samples that are processed by another simulation system component and delay the digital data samples by a selectable first delay time that is greater than or equal to the sample time period. The fine delay module is configured to receive the digital data samples and filter the digital data samples to represent delay by a selectable second delay time that is less than the sample time period. The doppler shift module is configured to receive the digital data samples and adjust a value of a frequency content of the fine delayed samples. |
| FILED | Monday, October 17, 2022 |
| APPL NO | 17/967468 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/4021 (20130101) G01S 7/4052 (20130101) Original (OR) Class G01S 7/4095 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230109146 | Gaehle |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Gregory Gaehle (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Gregory Gaehle (St. Louis, Missouri) |
| ABSTRACT | Among the various aspects of the present disclosure is the provision of methods for producing radioisotopes and improving the specific activity of radioisotopes (e.g., Cu-64 chloride). As described herein, the method includes matching of the target material and the proton beam strike area or the proton beam strike shape, resulting in improved specific activity while reducing the amount of target material used. |
| FILED | Wednesday, October 05, 2022 |
| APPL NO | 17/960279 |
| CURRENT CPC | Conversion of Chemical Elements; Radioactive Sources G21G 1/10 (20130101) Original (OR) Class G21G 2001/0094 (20130101) Techniques for Handling Particles or Ionising Radiation Not Otherwise Provided For; Irradiation Devices; Gamma Ray or X-ray Microscopes G21K 5/08 (20130101) Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 6/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230109371 | Fernandez |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BATTELLE MEMORIAL INSTITUTE (Richland, Washington) |
| ASSIGNEE(S) | BATTELLE MEMORIAL INSTITUTE (Richland, Washington) |
| INVENTOR(S) | Carlos A. Fernandez (Richland, Washington) |
| ABSTRACT | Examples of new polymer-modified cement formulations with self-healing capability at ambient temperature are described. These polymer-modified cements can be readily mixed with typical fine and coarse aggregates to build new concrete structures. One example of such a formulation includes a concrete comprising a MBA-BDA polymer having bond forming chemical functionality configured to form a bonding matrix between the polymer and at least one component of the concrete at a temperature less than 50 degrees C. wherein the matrix obtains at least 70% recovery of compressive strength after a damage event. |
| FILED | Wednesday, September 28, 2022 |
| APPL NO | 17/955030 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 24/006 (20130101) C04B 24/06 (20130101) C04B 24/42 (20130101) C04B 24/2652 (20130101) Original (OR) Class C04B 26/20 (20130101) C04B 2103/0046 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230109450 | Sun et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pingping Sun (Downers Grove, Illinois); Guiyan Zang (Woodridge, Illinois); Theodore R. Krause (Naperville, Illinois); Amgad A. Elgowainy (Lisle, Illinois); Ryan Hackler (Chicago, Illinois); Massimiliano Delferro (Chicago, Illinois); Vincenzo Cappello (Chicago, Illinois) |
| ABSTRACT | A process for converting plastic feedstock into a lubricant on an industrial scale can include a reactor having a filter integrated therein to allow for separation and recovery of catalyst so it can be washed and reused in subsequent conversion processes. Such recycling of the catalyst can allow for an industrial scale conversion process. |
| FILED | Tuesday, August 02, 2022 |
| APPL NO | 17/816899 |
| CURRENT CPC | Lubricating Compositions; Use of Chemical Substances Either Alone or as Lubricating Ingredients in a Lubricating Composition C10M 107/04 (20130101) C10M 177/00 (20130101) Original (OR) Class Indexing Scheme Associated With Subclass C10M Relating to Lubricating Compositions C10N 2070/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20230103984 | Gin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado); The Trustees Of The University Of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Douglas L. Gin (Longmont, Colorado); Patrick Li (Broomfield, Colorado); Chinedum Osuji (Gladwyne, Pennsylvania); Omar Imran (Philadelphia, Pennsylvania); Christopher Johnson (Philadelphia, Pennsylvania); Samantha S. Dyer (Boulder, Colorado) |
| ABSTRACT | The present disclosure relates, in part, to compositions comprising the compound of Formula (I), and polymerized compositions thereof. In certain embodiments, the compositions further comprise at least one compound of Formula (IIa) and Formula (IIb). In another aspect, the present disclosure relates to methods of preparation of the polymer compositions of the present disclosure, the method comprising contacting the compound of Formula (I) and a photoinitiator in the presence of a solvent to form a gyroid mesophase gel and irradiating the gyroid mesophase gel with UV light. In certain embodiments, the contacting further comprises at least one compound of Formula (IIa) and Formula (IIb). |
| FILED | Tuesday, September 20, 2022 |
| APPL NO | 17/949072 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 233/38 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 36/22 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230104480 | Polt et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ARIZONA BOARO OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robin L. Polt (Tucson, Arizona); Dillon Hanrahan (Tucson, Arizona); Lajos Z. Szabo (Tucson, Arizona); Michael L. Heien (Tucson, Arizona); Chenxi Liu (Tucson, Arizona) |
| ABSTRACT | Methods for quality control and optimizing the formation and characterization of micelles, vesicles or other aggregates are described herein. Pharmaceutically relevant peptides may be modified to form glycopeptide surfactants which form micelles or other aggregates with another surfactant. Glycopeptide and glycolipid surfactants can aggregate to form particles that enhance drug delivery. The glycopeptide surfactants may be drugs or prodrugs which are delivered via the micelles or other aggregated structures. |
| FILED | Monday, November 21, 2022 |
| APPL NO | 18/057665 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1272 (20130101) Original (OR) Class A61K 38/07 (20130101) A61K 38/08 (20130101) A61K 38/085 (20130101) A61K 38/095 (20190101) A61K 38/1866 (20130101) A61K 47/12 (20130101) A61K 47/18 (20130101) A61K 47/20 (20130101) A61K 47/26 (20130101) A61K 47/186 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230104822 | Alqasemi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Redwan Alqasemi (Wesley Chapel, Florida); Paul Mitzlaff (Palm Harbor, Florida); Andoni Aguirrezabal (Tampa, Florida); Lei Wu (Tampa, Florida); Karl Rothe (Rockledge, Florida); Rajiv Dubey (Tampa, Florida) |
| ABSTRACT | In one embodiment, a robotic end effector configured to mount to a robotic manipulator includes gripping elements configured to grasp objects, a drive mechanism configured to open and close the gripping elements, a central controller configured to control operation of the drive mechanism and the gripper elements, the central controller hosting a control program that enables control of the end effector independent of the robotic manipulator, and at least one of a forward-facing ultrasonic distance sensor configured to measure a distance between the gripping elements and an object to be grasped, and a forward-facing camera mounted between the gripping elements configured to capture video data of an object to be grasped. |
| FILED | Monday, December 05, 2022 |
| APPL NO | 18/074778 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 15/022 (20130101) B25J 15/0028 (20130101) B25J 15/0033 (20130101) B25J 15/0038 (20130101) Original (OR) Class B25J 15/0266 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230104995 | Voitiuk et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kateryna Voitiuk (Santa Cruz, California); David H. Haussler (Santa Cruz, California); Mircea Teodorescu (Santa Cruz, California) |
| ABSTRACT | An electrophysiological recording and stimulation system includes an electrophysiological device coupled to neural tissue and configured to measure neural electrophysiological signals. The system also includes a computing device coupled to the electrophysiological device and configured to receive neural electrophysiological signals from the electrophysiological device, and transmit neural stimulating signals to the neural tissue through the electrophysiological device based on the neural electrophysiological signals. |
| FILED | Tuesday, October 04, 2022 |
| APPL NO | 17/960093 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5082 (20130101) Original (OR) Class Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) G16B 40/20 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230105233 | Chilkoti et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ashutosh Chilkoti (Durham, North Carolina); Stefan Roberts (Durham, North Carolina) |
| ABSTRACT | Compositions and methods disclosed herein can provide complex protein-based structures that can be used in biomedical applications. An example composition includes an assembly that includes disordered polypeptides and partially ordered polypeptides. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/798868 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5052 (20130101) Original (OR) Class A61K 9/5089 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230105479 | Lee et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Gabsang Lee (Ellicott City, Maryland); Hyesoo Kim (Baltimore, Maryland); InYoung Choi (Baltimore, Maryland); HoTae Lim (Baltimore, Maryland); Alex V. Huynh (Baltimore, Maryland) |
| ABSTRACT | The present invention relates to the field of stem cells. More specifically, the present invention provides compositions and methods for using optogenetics to sustain the pluripotency of stem cells. In one embodiment, a vector comprises a nucleotide sequencing encoding a fusion protein comprising the intracellular domain of fibroblast growth factor 1 receptor (FGFR1) and a photoactivatable domain. |
| FILED | Friday, September 30, 2022 |
| APPL NO | 17/957998 |
| CURRENT CPC | Peptides C07K 14/71 (20130101) C07K 14/405 (20130101) Original (OR) Class C07K 2319/02 (20130101) Apparatus for Enzymology or Microbiology; C12M 31/10 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0606 (20130101) C12N 5/0696 (20130101) C12N 13/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230106721 | Catania et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chelsea Catania (Somerville, Massachusetts); Ariel Furst (Cambridge, Massachusetts); Gang Fan (Jamaica Plain, Massachusetts); Pris Wasuwanich (Orlando, Florida) |
| ABSTRACT | Prokaryotic cells having a metal-phenolic network coating are disclosed, as are compositions including such cells, methods for their use, and methods for producing such cells. |
| FILED | Friday, August 05, 2022 |
| APPL NO | 17/817710 |
| CURRENT CPC | Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 33/135 (20160801) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 35/742 (20130101) Original (OR) Class A61K 47/52 (20170801) A61K 47/6903 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230106858 | Dos Santos et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Florida State University Research Foundation, Inc. (Tallahassee, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nikolas Ramos Dos Santos (Tallahassee, Florida); Igor Alabugin (Tallahassee, Florida); Alexandria Palazzo (Tallahassee, Florida) |
| ABSTRACT | Methods of forming arenes, including asymmetrical arenes, such as asymmetrical pyrene derivatives. Substituents of starting materials may be selected to direct a photochemical cascade and possibly a 1,2-aryl shift. The methods may include a Mallory cyclization, which is controlled, at least in part, by substituents of the starting materials. Compounds and compositions including asymmetrical arenes. |
| FILED | Tuesday, September 06, 2022 |
| APPL NO | 17/903529 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 5/393 (20130101) C07C 6/04 (20130101) Original (OR) Class C07C 15/38 (20130101) C07C 2603/50 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230107049 | Miller et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE CLEVELAND CLINIC FOUNDATION (Cleveland, Ohio); UNIVERSITY OF UTAH, CENTER FOR TECHNOLOGY & VENTURE COMMERCIALIZATION (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aaron Miller (Cleveland, Ohio); Denise Dearing (Salt Lake City, Utah); Manoj Monga (Cleveland, Ohio) |
| ABSTRACT | A method of determining the risk that a subject will develop urinary stone disease (USD) or hyperoxaluria is described. The method includes conducting a differential abundance analysis of the bacteria present in a stool and/or urine sample obtained from the subject, determining the ratio of bacteria associated with health to bacteria associated with USD or hyperoxaluria present in the subject’s stool and/or urine sample, and assigning a level of risk for developing USD or hyperoxaluria based on the ratio. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/802597 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/74 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/06 (20130101) C12Q 1/689 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230107117 | DAS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CITY OF HOPE (Duarte, California); CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California); THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | CITY OF HOPE (Duarte, California); CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California); THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts) |
| INVENTOR(S) | Saumya DAS (Boston, Massachusetts); Ane Miren SALVADOR GARICANO (Boston, Massachusetts); Si-ping HAN (Duarte, California); Lisa SCHERER (Duarte, California); Julia DEROGATIS (Duarte, California); Robin HU (Duarte, California); Sahil SAGAR (Duarte, California); William A. GODDARD, III (Pasadena, California); John ROSSI (Duarte, California) |
| ABSTRACT | Disclosed herein are conditional siRNAs activatable by pro-hypertrophic RNA sequences and use thereof for treating conditions such as cardiac hypertrophy. The conditional siRNAs target calcineurin or HDAC2. |
| FILED | Friday, August 10, 2018 |
| APPL NO | 16/638107 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) Original (OR) Class C12N 15/1137 (20130101) C12N 2310/315 (20130101) C12N 2310/3515 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230107506 | Shan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Junyi Shan (Pasadena, California); Mengxing Ye (Santa Barbara, California); Leon Balents (Santa Barbara, California); David Hsieh (San Marino, California) |
| ABSTRACT | A control circuit for controlling a timing, a pulse length, a valve electric field having the certain magnitude, and a pulse envelope of the valve electric field, so as to coherently control a response of a region of an insulator to a probe electric field, the response controlled with a temporal resolution equal to the pulse length and matching the pulse envelope. |
| FILED | Thursday, September 08, 2022 |
| APPL NO | 17/940661 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 29/0885 (20130101) Original (OR) Class Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/0081 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230108142 | Laurencin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Connecticut (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cato Laurencin (Avon, Connecticut); Godwin Dzidotor (Manchester, Connecticut); Yusuf Khan (Hamden, Connecticut); Seyed Amir Seyedsalehi (Vernon, Connecticut) |
| ABSTRACT | Disclosed herein is a brace for regeneration of tissue in a knee comprising a sleeve and a first strut; where the first strut comprises an upper portion comprising a first jig; where the first jig comprises a slot for hosting a first strap that is in contact with the sleeve; a central portion that comprises a central strut that is in fluid communication with an actuator located on a first side of the knee that imposes a force on the knee; where the force is inclined at an angle to a longitudinal axis of the first strut; and a lower portion that comprises a second jig; where the second jig comprises a slot for hosting a second strap that contacts the sleeve at an opposite end relative to a position that the first strap contacts the sleeve. |
| FILED | Thursday, October 06, 2022 |
| APPL NO | 17/961416 |
| CURRENT CPC | Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 1/024 (20130101) Original (OR) Class A61H 2201/165 (20130101) A61H 2201/1238 (20130101) A61H 2201/1659 (20130101) A61H 2201/1673 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230108381 | SHARMA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TEXAS A and M UNIVERSITY SYSTEM (College Station, Texas); The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | THE TEXAS A and M UNIVERSITY SYSTEM (College Station, Texas); The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | Virender K. SHARMA (College Station, Texas); Chetan JINADATHA (Belton, Texas) |
| ABSTRACT | Methods for disinfecting a surface are provided which include contacting a surface with a solution comprising Fe(VI)O42−, thereby disinfecting the surfaces. In some cases, the surface to be contacted with the solution is in a space suitable for human occupancy and the surface is arranged in the ambient of the space. In addition, solutions comprising Fe(VI)O42− are provided. The solutions may additionally include a hypohalite salt and a surfactant. |
| FILED | Thursday, December 08, 2022 |
| APPL NO | 18/063319 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 25/02 (20130101) A01N 25/30 (20130101) A01N 59/08 (20130101) A01N 59/16 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230109020 | AKSIMENTIEV et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois); Cambridge Enterprise Limited (Cambridge, United Kingdom) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aleksei AKSIMENTIEV (Urbana, Illinois); Ulrich F. KEYSER (Cambridge, United Kingdom) |
| ABSTRACT | The present invention provides compositions and methods for transferring phospholipids and other molecules between the leaflets of a cell membrane. The compositions comprise at least one nucleic acid or compound having a hydrophilic region, where the composition is able to form a nanostructure that forms a toroidal pore in a lipid membrane. The nucleic acid or hydrophilic region-containing compound further contains an attached molecule capable of inserting the nanostructure into the lipid membrane. The invention also provides methods for scrambling lipids and other molecules in a cell membrane, which can be used to alter the function of a selected cell or to facilitate the death of the cell. The scrambling activity of synthetic scramblases described herein outperforms previously known enzymatically active DNA nanostructures and naturally occurring scramblases, in some cases by several orders of magnitude. |
| FILED | Friday, September 09, 2022 |
| APPL NO | 17/941835 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5146 (20130101) A61K 31/711 (20130101) A61K 31/713 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0006 (20130101) Original (OR) Class C12N 15/11 (20130101) C12N 15/111 (20130101) C12N 2310/3515 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230109441 | Balapour et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Drexel University (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mohammad Balapour (Philadelphia, Pennsylvania); Yaghoob Farnam (Philadelphia, Pennsylvania) |
| ABSTRACT | Off-spec fly ash-based spherical lightweight aggregate (LWA), designated SPoRA, was manufactured and its engineering properties, including specific gravity, dry rodded unit weight, water absorption, mechanical performance, and pore structure, were evaluated. Using the characterized SPoRA, lightweight concrete (LWC) samples were made and properties of the LWC were assessed and compared with samples made using the traditional LWA. The results indicated that fine and coarse SPoRA had 72 h absorption capacities of 16.4% and 20.9%, respectively, which were higher than that of traditional LWA. SPoRA had a saturated surface dry (SSD) specific gravity higher than traditional LWA, which resulted in higher fresh density for the LWC prepared with SPoRA. Large spherical type pores were found for SPoRA similar to the traditional slate-based LWA. The pore size distribution of SPoRA, characterized using a dynamic vapor sorption analyzer, indicated that more than 97% of the pores had pore diameters greater than 50 nm. |
| FILED | Tuesday, August 30, 2022 |
| APPL NO | 17/899458 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 18/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20230104288 | Bonnell |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Clayton C. Bonnell (Fairfax, Virginia) |
| ABSTRACT | In some aspects, methods and systems for a digital trust architecture are provided. In some aspects, the architecture includes a user account provisioning process. The provisioning process may make use of in person verifications of some personal information to ensure authenticity of the user information. Once the authenticity of user information is established, an account may be created. The user account may include a user email account, with integrated access to digital certificates linked to the user account. Account creation may also automatically publish the new user's public key in a publicly accessible directory, enabling encrypted email information to be easily sent to the new user. |
| FILED | Monday, December 12, 2022 |
| APPL NO | 18/064729 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/6245 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/006 (20130101) H04L 9/32 (20130101) Original (OR) Class H04L 9/50 (20220501) H04L 9/0861 (20130101) H04L 9/3239 (20130101) H04L 9/3247 (20130101) H04L 9/3268 (20130101) H04L 63/123 (20130101) H04L 63/0442 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230107700 | Klausner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter Jay Klausner (Scottsdale, Arizona); Robert E. Dixon, Jr. (Haymarket, Virginia) |
| ABSTRACT | Systems and methods for universal item returns. A universal returns systems allows a user the ability to return an item via a distribution network whether the item was purchased at a retail location, delivered by the distribution network, or delivered by another entity. The universal returns system comprises a user interface a return request. Based on the return request, the system obtains transaction information, provides a return code, and allows scheduling item pick-up. |
| FILED | Monday, December 12, 2022 |
| APPL NO | 18/064473 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/953 (20190101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 7/1417 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 20/407 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230109266 | Luckay et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan M. Luckay (Vienna, Virginia); Robert E. Dixon, JR. (Haymarket, Virginia); Gregory Cooil (Arlington, Virginia) |
| ABSTRACT | Autonomous delivery drop points for delivery of an item are provided. The autonomous delivery drop points can include a proxy sensor to communicate information related to the autonomous delivery drop point to an autonomous delivery vehicle. The autonomous delivery drop points can include a delivery inlet configured to accept the item. The autonomous delivery drop points can include a storage receptacle configured to store the item until the item is retrieved by the owner of the item. The autonomous delivery drop points can include an attachment member coupled to the item. The autonomous delivery drop points can include a hook configured to couple to the attachment member to accept the item, wherein the hook comprises the proxy sensor. |
| FILED | Friday, September 09, 2022 |
| APPL NO | 17/930849 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 39/024 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 1/12 (20130101) Original (OR) Class Systems for Controlling or Regulating Non-electric Variables G05D 1/0094 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/0836 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20230105757 | Schultz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa) |
| ASSIGNEE(S) | UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa) |
| INVENTOR(S) | Michael K. Schultz (Iowa City, Iowa); Somya Kapoor (Iowa City, Iowa); Douglas R. Spitz (Iowa City, Iowa) |
| ABSTRACT | The present invention relates to a process of removing free-unlabeled radionuclides from a radiopharmaceutical prior to administering the radiopharmaceutical to the patient using size-exclusion or ion-exchange mechanisms. |
| FILED | Thursday, November 10, 2022 |
| APPL NO | 17/985015 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/198 (20130101) Original (OR) Class A61K 39/3955 (20130101) A61K 2039/545 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230106124 | Nansteel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Mark Nansteel (Egg Harbor Township, New Jersey); Xianzhi Yang (Cherry Hill, New Jersey); Roger Veldman (Dorr, Michigan); Chih-Tsai Chen (Moorestown, New Jersey); Matthew Ghent (Bel Air, Maryland) |
| ABSTRACT | Examples are directed towards apparatuses, systems, and methods. For example, an apparatus includes a weight including a first side and a second side. The first side of the weight forms a receiving hole in the first side. A pin includes a first end and a second end. The second end of the pin is inserted into the receiving hole of the weight. The pin includes a reduced portion. A pin detonator is coupled to the reduced portion of the pin to sever the pin when detonated. |
| FILED | Wednesday, October 05, 2022 |
| APPL NO | 17/960190 |
| CURRENT CPC | Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 5/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 20230103556 | Lin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wendy Wenling Lin (Montgomery, Ohio); David Herman (Beavercreek, Ohio) |
| ABSTRACT | A system and method for bonding together a facesheet and an acoustic screen of an acoustic liner using a solid adhesive film having a first adhesive side opposite a second adhesive side are provided. The system includes a solid adhesive film having a first adhesive side opposite a second adhesive side; an acoustic screen bonded to the first adhesive side of the solid adhesive film; and a facesheet bonded to the second adhesive side of the solid adhesive film. The method includes bonding the facesheet to the first adhesive side of the solid adhesive film and bonding the acoustic screen to the second adhesive side of the solid adhesive film. |
| FILED | Tuesday, October 05, 2021 |
| APPL NO | 17/449980 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 3/12 (20130101) B32B 5/028 (20130101) B32B 7/12 (20130101) B32B 37/1284 (20130101) B32B 38/04 (20130101) B32B 41/00 (20130101) B32B 2038/047 (20130101) B32B 2307/102 (20130101) B32B 2310/0843 (20130101) B32B 2605/18 (20130101) Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 7/38 (20180101) Jet-propulsion Plants F02K 1/827 (20130101) Sound-producing Devices; Methods or Devices for Protecting Against, or for Damping, Noise or Other Acoustic Waves in General; Acoustics Not Otherwise Provided for G10K 11/168 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230104455 | Lascara et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The MITRE Corporation (McLean, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brock J. Lascara (Charlottesville, Virginia); John Miller Timberlake, III (Arlington, Virginia); Lesley A. Weitz (Vienna, Virginia); Mitch Wynnyk (McLean, Virginia) |
| ABSTRACT | Disclosed herein are system, method, and computer program product embodiments for evaluating accuracy of estimated time of arrival predictions by an air traffic management tool for scheduling aircraft. Evaluation may include comparing predicted trajectories across any number of flights with actual trajectories to determine estimate time of arrival errors and statistics. Evaluation may further involve a visualization system that includes processing flight data into a visualization format and providing a graphical user interface for interacting with the predicted and actual trajectories. The graphical user interface provides an interactive display for manipulating the predicted and actual trajectories on an individual flight basis or across flights. |
| FILED | Monday, October 04, 2021 |
| APPL NO | 17/493395 |
| CURRENT CPC | Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 43/00 (20130101) B64D 45/00 (20130101) Traffic Control Systems G08G 5/0013 (20130101) G08G 5/0043 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20230103708 | Vetter et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MUSC Foundation for Research Development (Charleston, South Carolina); University of Utah Research Foundation (Salt Lake City, Utah); University of Florida Research Foundation, Inc. (Gainesville, Florida); The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Monica Vetter (Salt Lake City, Utah); Alejandra Bosco (Salt Lake City, Utah); Baerbel Rohrer (Charleston, South Carolina); Stephen Tomlinson (Charleston, South Carolina); William W. Hauswirth (Gainesville, Florida) |
| ABSTRACT | Recombinant vectors operably encoding a CR2-FH fusion protein comprising a CR2 portion comprising CR2 protein or a fragment thereof and a FH portion comprising a factor H protein or a fragment thereof, and pharmaceutical compositions comprising the recombinant vector, are described. Also provided are methods of using the compositions for treatment eye diseases such as macular degeneration or glaucoma. |
| FILED | Thursday, June 16, 2022 |
| APPL NO | 17/842225 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/06 (20180101) Peptides C07K 14/70596 (20130101) C07K 2317/23 (20130101) C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/861 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230108381 | SHARMA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TEXAS A and M UNIVERSITY SYSTEM (College Station, Texas); The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | THE TEXAS A and M UNIVERSITY SYSTEM (College Station, Texas); The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | Virender K. SHARMA (College Station, Texas); Chetan JINADATHA (Belton, Texas) |
| ABSTRACT | Methods for disinfecting a surface are provided which include contacting a surface with a solution comprising Fe(VI)O42−, thereby disinfecting the surfaces. In some cases, the surface to be contacted with the solution is in a space suitable for human occupancy and the surface is arranged in the ambient of the space. In addition, solutions comprising Fe(VI)O42− are provided. The solutions may additionally include a hypohalite salt and a surfactant. |
| FILED | Thursday, December 08, 2022 |
| APPL NO | 18/063319 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 25/02 (20130101) A01N 25/30 (20130101) A01N 59/08 (20130101) A01N 59/16 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20230105528 | Wehner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Stratom, Inc. (Boulder, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ross Wehner (Bouulder, Colorado); Ryan Marsini (Frederick, Colorado); Ryan Delgizzi (Arvada, Colorado); Mark Gordon (Lafayette, Colorado); Jesse Weifenbach (Thornton, Colorado); David Regan (Arvada, Colorado) |
| ABSTRACT | A cargo transport system is provided that has an ability to move cargo in an autonomous or semi-autonomous manner, using a compact lift vehicle capable of lifting relatively heavy objects. The system includes a cargo loading system, a sensor suite coupled with a controller, dunnage detection, cross-decking capability, cargo stacking capability, autonomous navigation, tip detection and prevention, or any combinations thereof. The system may include a fork assembly coupled with a mast and movable in a vertical direction relative to the mast. Further, the mast may be coupled with a platform or deck and movable in a horizontal direction relative to the platform, to allow the fork assembly to be lowered below a top plane of the platform when the mast is at a forward location relative to the platform. The controller and sensor suite and may provide for autonomous or semi-autonomous control and movement of the cargo transport system. |
| FILED | Tuesday, December 06, 2022 |
| APPL NO | 18/075614 |
| CURRENT CPC | Vehicles Adapted for Load Transportation or to Transport, to Carry, or to Comprise Special Loads or Objects B60P 1/36 (20130101) Original (OR) Class Servicing, Cleaning, Repairing, Supporting, Lifting, or Manoeuvring of Vehicles, Not Otherwise Provided for B60S 9/10 (20130101) Motor Vehicles; Trailers B62D 55/065 (20130101) Hoisting, Lifting, Hauling or Pushing, Not Otherwise Provided For, e.g Devices Which Apply a Lifting or Pushing Force Directly to the Surface of a Load B66F 9/063 (20130101) B66F 9/195 (20130101) B66F 9/07559 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230106126 | Wehner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Stratom, Inc. (Boulder, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ross Wehner (Boulder, Colorado); Ryan Marsini (Frederick, Colorado); Ryan Delgizzi (Arvada, Colorado); Mark Gordon (Lafayette, Colorado); Jesse Weifenbach (Thornton, Colorado); David Regan (Arvada, Colorado) |
| ABSTRACT | A cargo transport system is provided that has an ability to move cargo in an autonomous or semi-autonomous manner, using a compact lift vehicle capable of lifting relatively heavy objects. The system includes a cargo loading system, a sensor suite coupled with a controller, dunnage detection, cross-decking capability, cargo stacking capability, autonomous navigation, tip detection and prevention, or any combinations thereof. The system may include a fork assembly coupled with a mast and movable in a vertical direction relative to the mast. Further, the mast may be coupled with a platform or deck and movable in a horizontal direction relative to the platform, to allow the fork assembly to be lowered below a top plane of the platform when the mast is at a forward location relative to the platform. The controller and sensor suite and may provide for autonomous or semi-autonomous control and movement of the cargo transport system. |
| FILED | Tuesday, December 06, 2022 |
| APPL NO | 18/075616 |
| CURRENT CPC | Vehicles Adapted for Load Transportation or to Transport, to Carry, or to Comprise Special Loads or Objects B60P 1/36 (20130101) Original (OR) Class Servicing, Cleaning, Repairing, Supporting, Lifting, or Manoeuvring of Vehicles, Not Otherwise Provided for B60S 9/10 (20130101) Motor Vehicles; Trailers B62D 55/065 (20130101) Hoisting, Lifting, Hauling or Pushing, Not Otherwise Provided For, e.g Devices Which Apply a Lifting or Pushing Force Directly to the Surface of a Load B66F 9/063 (20130101) B66F 9/195 (20130101) B66F 9/07559 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20230107007 | LU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland); Government of the United States of America, as Represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiyuan LU (Montgomery Village, Maryland); Kartik SRINIVASAN (Rockville, Maryland) |
| ABSTRACT | A system for generating a coherent laser light includes a light source configured to pump a first color laser light and a device configured to generate a coherent second color light and a coherent third color light. The device includes a waveguide configured to couple to the light source and a microring resonator coupled to the light source via the waveguide. The microring resonator is configured to generate a coherent second color light and a coherent third color light. The generation of the coherent second color light and the coherent third color light is based on hybrid-mode optical parametric oscillation. |
| FILED | Tuesday, October 04, 2022 |
| APPL NO | 17/959538 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/392 (20210101) G02F 1/395 (20130101) G02F 1/3544 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/063 (20130101) H01S 3/0627 (20130101) H01S 3/1083 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Education (ED)
| US 20230105867 | Ballesteros et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Miguel Ballesteros (Pittsburgh, Pennsylvania); Maria Luz Rello-Sanchez (Pittsburgh, Pennsylvania) |
| ABSTRACT | This document describes a data processing system for processing a feature vector that comprises features (one or more) that are indicative of dyslexic behavior that are indicative of dyslexic behavior. The data processing system includes a feature classification engine that generates classification metrics for a feature vector. Machine learning logic is used to determine a classification metric for each feature. Features that have a classification metric below a pre-determined threshold are removed. The data processing system includes a prediction engine that generates a prediction value indicative of a predicted likelihood of dyslexia. The prediction engine assigns, to each remaining feature, based on the classification metric of the respective remaining feature, a prediction weight and determines the prediction value based on the prediction weights. |
| FILED | Thursday, May 12, 2022 |
| APPL NO | 17/743156 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/0445 (20130101) G06N 5/04 (20130101) Original (OR) Class G06N 20/00 (20190101) G06N 20/10 (20190101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Justice (DOJ)
| US 20230105167 | Green et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard E. Green (Santa Cruz, California); Remy Nguyen (Santa Cruz, California) |
| ABSTRACT | Provided are computer-implemented methods for comparing genotype data from a first sample to a limited amount of DNA sequence data from a second sample. In certain embodiments, the first sample is from a known individual and the second sample is an unknown sample. The methods find use in a variety of contexts, including for genetic identity detection, e.g., for forensic and other applications. Also provided are computer-implemented methods for assessing the degree of relatedness between genotype data from a first sample and a limited amount of DNA sequence data from a second sample. Computer-readable media and systems that find use in practicing the methods of the present disclosure are also provided. |
| FILED | Wednesday, September 14, 2022 |
| APPL NO | 17/944855 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/20 (20190201) Original (OR) Class G16B 20/40 (20190201) G16B 30/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of the Interior (DOI)
| US 20230106158 | Suhr et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BiomiLab, LLC (East Lansing, Michigan) |
| ASSIGNEE(S) | BiomiLab, LLC (East Lansing, Michigan) |
| INVENTOR(S) | Steven T. Suhr (Okemos, Michigan); Marie-Claude Senut (Okemos, Michigan) |
| ABSTRACT | The current disclosure provides methods and compositions useful in preparing transformed and immortalized zebra and quagga mussel cells that function as disseminated neoplastic (DN) cells, as well as the cells produced thereby. In particular, these cells are immortalized through modifying expression of the TERT nucleic acid and/or protein. Also provided are methods for using such mussel DNCs in cell culture, in vitro, and within live mussels in the lab or in the wild, to control mussel populations such as invasive zebra mussel or quagga mussel populations. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/904282 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 63/10 (20200101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0601 (20130101) C12N 9/22 (20130101) C12N 9/1276 (20130101) C12N 15/11 (20130101) C12N 15/90 (20130101) C12N 2310/20 (20170501) C12N 2510/04 (20130101) C12N 2800/80 (20130101) Enzymes C12Y 207/07049 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20230106382 | Crouse et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Phoebus Optoelectronics LLC (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Thomas Crouse (Canton, New York); Igor Bendoym (Brooklyn, New York); Lori Ann Lepak (Ithaca, New York) |
| ABSTRACT | A device, or a pixel of a device, for filtering of incident radiation includes an array of discrete micro-resonant elements in an encapsulated layer, the encapsulating material having a lower index of refraction than the micro-resonant elements. A highly reflective filtering structure is positioned a first distance above the encapsulated layer and/or a second distance below the encapsulated layer, and is characterized by a stopband. The array of discrete micro-resonant elements is configured to transmit a passband of incident radiation centered around a center wavelength that falls within the stopband of the highly reflective filtering structure, and to minimize a dependence of the center wavelength on an angle of incidence (AoI) of the incident radiation. A pixelated device includes a plurality of pixels, each having an array of the discrete micro-resonant elements tuned to transmit a different passband having a different center wavelength, while minimizing dependence on AoI. |
| FILED | Monday, October 03, 2022 |
| APPL NO | 17/958703 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 5/26 (20130101) Original (OR) Class G02B 5/201 (20130101) G02B 5/208 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Geospatial Intelligence Agency (NGA)
| US 20230105609 | Starr et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States of America, as represented by the Director, National Geospatial-Intelligence Agency (Springfield, Virginia) |
| ASSIGNEE(S) | United States of America, as represented by the Director, National Geospatial-Intelligence Agency (Springfield, Virginia) |
| INVENTOR(S) | Michael A. Starr (Charlottesville, Virginia); Alexander J. Mulia (Crozet, Virginia) |
| ABSTRACT | Systems and methods for performing quality assurance assessments for unattended computer vision counting tools are presented. Classification information is used to generate coefficients for error equations. Digital filters are used to train and update these coefficients. These coefficients are used to determine object count uncertainty ranges for an area of interest. |
| FILED | Thursday, December 01, 2022 |
| APPL NO | 18/073017 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 1/0014 (20130101) Original (OR) Class G06T 7/70 (20170101) G06T 2207/30242 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Security Agency (NSA)
| US 20230106030 | Seyedi |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HEWLETT PACKARD ENTERPRISE DEVELOPMENT LP (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mir Ashkan Seyedi (Milpitas, California) |
| ABSTRACT | Systems, methods, and computer-readable media are described for performing link training to enable optical pass-through (OPT) capabilities of a network node. OPT capabilities may refer to on-chip wavelength routing for a multi-wavelength data input, whereby an intermediate node detects wavelengths that are intended for OPT and transparently passes the wavelengths through to downstream nodes. When executed at an intermediate network node, an OPT link training algorithm can result in the creation of one or more wavelength routing maps that associate wavelengths received on particular inputs to the node with particular outputs of the node. An intermediate node may generate a respective wavelength routing map for each transmit node from which it receives input data. The wavelength routing maps may together implement OPT capabilities at the intermediate node as each wavelength routing map may indicate the manner in which wavelengths are passed through the intermediate node for a given transmit node. |
| FILED | Wednesday, October 06, 2021 |
| APPL NO | 17/495789 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/12007 (20130101) G02B 6/29338 (20130101) Transmission H04B 10/25 (20130101) H04B 10/50 (20130101) H04B 10/60 (20130101) Multiplex Communication H04J 14/0227 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20230103658 | Agee |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Brian G. Agee (San Jose, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian G. Agee (San Jose, California) |
| ABSTRACT | An apparatus and digital signal processing means are disclosed for excision of co-channel interference from signals received in crowded or hostile environments using spatial/polarization diverse arrays, which reliably and rapidly identifies communication signals with transmitted features that are self-coherent over known framing intervals due to known attributes of the communication network, and exploits those features to develop diversity combining weights that substantively excise that co-channel interference from those communication signals, based on differing diversity signature, timing offset, and carrier offset between the network signals and the co-channel interferers. In one embodiment, the co-channel interference excision is performed in an appliqué that can be implemented without coordination with a network transceiver. |
| FILED | Monday, September 12, 2022 |
| APPL NO | 17/803636 |
| CURRENT CPC | Transmission H04B 7/0617 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 25/08 (20130101) Original (OR) Class H04L 27/264 (20130101) H04L 27/26414 (20210101) H04L 27/26538 (20210101) Wireless Communication Networks H04W 28/14 (20130101) H04W 52/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230105213 | Johnson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher R. Johnson (Fairfield, Ohio); Thomas J. Lipinski (Monroe, Ohio); Eric Schroeder (Loveland, Ohio); Carlos Fernandez (Hamilton, Ohio); David A. Perveiler (West Chester, Ohio) |
| ABSTRACT | Diffuser apparatus for turbine frames and outlet guide vanes are disclosed. An example diffuser is integrated into a turbine engine. The example diffuser includes a plurality of struts extending between an inner portion and an outer portion of the turbine engine; and a plurality of flowpath surfaces supported by the plurality of struts. The example plurality of flowpath surfaces extends circumferentially within the turbine engine at a plurality of radial spans to control diffusion of air flow within the turbine engine. |
| FILED | Monday, October 04, 2021 |
| APPL NO | 17/493318 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 9/041 (20130101) Original (OR) Class F01D 25/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230107068 | Imhoff |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Scott Allen Imhoff (Parker, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott Allen Imhoff (Parker, Colorado) |
| ABSTRACT | Systems, devices, methods, and computer-readable media for location determination of an orbiting device. A method can include receiving measurement data from a monitor device, the measurement data representative of a position of an orbiting space object with a mechanically moveable antenna, receiving, by processor circuitry, mission data indicating orientation of the antenna is changing from a first orientation to a second, different orientation by a specified time, determining, based on the mission data, an inter-signal correction (ISC), applying the determined ISC to the measurement data resulting in corrected measurement data, providing the corrected measurement data to a Kalman filter, and receiving, from the Kalman filter, a position estimate of the orbiting space object. |
| FILED | Monday, October 04, 2021 |
| APPL NO | 17/493461 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/66 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 19/07 (20130101) Original (OR) Class Transmission H04B 7/18513 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, April 06, 2023.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
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You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
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https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20230406.html
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