FedInvent™ Patent Applications
Application Details for Thursday, April 13, 2023
This page was updated on Thursday, April 13, 2023 at 05:09 AM GMT
Department of Health and Human Services (HHS)
| US 20230109833 | Aron et al. |
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| FUNDED BY |
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| APPLICANT(S) | MICROBIOTIX, INC. (Worcester, Massachusetts); THE PENN STATE RESEARCH FOUNDATION (University Park, Pennsylvania) |
| ASSIGNEE(S) | MICROBIOTIX, INC. (Worcester, Massachusetts); THE PENN STATE RESEARCH FOUNDATION (University Park, Pennsylvania) |
| INVENTOR(S) | Zachary D. Aron (Acton, Massachusetts); Steven M. Kwasny (Blackstone, Massachusetts); Matthew C. Torhan (Worcester, Massachusetts); Jay P. Barbor (Pasadena, California); Steven C. Cardinale (Hopedale, Massachusetts); Michelle M. Butler (Auburn, Massachusetts); Timothy J. Opperman (Arlington, Massachusetts); Kenneth C. Keiler (Boalsburg, Pennsylvania) |
| ABSTRACT | The present invention is related to the development of therapeutics and prophylactics for the treatment and/or prevention of bacterial infections in humans and other mammals. A new class of small molecules is disclosed that inhibits the bacterial trans-translation/ribosome rescue mechanism and thus blocks infection of host cells by bacteria. Also disclosed are methods of using the small molecule inhibitors in the treatment/prevention of bacterial infections. |
| FILED | Thursday, October 13, 2022 |
| APPL NO | 17/964994 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 43/82 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Heterocyclic Compounds C07D 271/113 (20130101) Original (OR) Class C07D 413/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230109863 | HAYES et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE PENN STATE RESEARCH FOUNDATION (UNIVERSITY PARK, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel J. HAYES (State College, Pennsylvania); Mohammad ABU-LABAN (State College, Pennsylvania) |
| ABSTRACT | In one aspect, compositions are described herein. A composition described herein comprises a nanoparticle, a therapeutic species, and a linker joining the nanoparticle to the therapeutic species. The linker joining the nanoparticle to the therapeutic species comprises a Diels-Alder cyclo-addition reaction product. Additionally, in some embodiments, the nanoparticle is a magnetic nanoparticle. |
| FILED | Wednesday, December 07, 2022 |
| APPL NO | 18/076772 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5094 (20130101) Original (OR) Class A61K 9/5115 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230109968 | SAWYERS et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Charles L. SAWYERS (New York, New York); Michael JUNG (Los Angeles, California); Charlie D. CHEN (Shanghai, China PRC); Samedy OUK (San Diego, California); Derek WELSBIE (Lutherville-Timonium, Maryland); Chris TRAN (New York, New York); John WONGVIPAT (New York, New York); Dongwon YOO (Los Angeles, California) |
| ABSTRACT | The present invention relates to diarylhydantoin compounds, including diarylthiohydantoins, and methods for synthesizing them and using them in the treatment of hormone refractory prostate cancer. |
| FILED | Wednesday, July 13, 2022 |
| APPL NO | 17/863841 |
| CURRENT CPC | Heterocyclic Compounds C07D 233/70 (20130101) C07D 233/74 (20130101) C07D 233/86 (20130101) C07D 235/02 (20130101) Original (OR) Class C07D 471/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230110249 | KIPPS et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas James KIPPS (San Diego, California); Jian YU (San Diego, California); Bing CUI (San Diego, California); Liguang CHEN (San Diego, California); George F. WIDHOPF (San Diego, California); Charles PRUSSAK (San Diego, California) |
| ABSTRACT | The present invention relates to pharmaceutical compositions and a method of inhibiting metastasis using anti-ROR1 antibodies or antigen binding fragments, ROR1 binding peptides and ROR1 vaccines. |
| FILED | Wednesday, March 16, 2022 |
| APPL NO | 17/696776 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/001102 (20180801) A61K 2039/505 (20130101) A61K 2039/6081 (20130101) Peptides C07K 14/435 (20130101) C07K 16/30 (20130101) Original (OR) Class C07K 16/2803 (20130101) C07K 16/3015 (20130101) C07K 2317/34 (20130101) C07K 2317/73 (20130101) C07K 2317/92 (20130101) C07K 2317/94 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230110313 | CONNOLLY et al. |
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| FUNDED BY |
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| APPLICANT(S) | Parker Institute for Cancer Immunotherapy (San Francisco, California); The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John CONNOLLY (Red Oak, Texas); Sean PARKER (San Francisco, California); Kenan Christopher GARCIA (San Francisco, California) |
| ABSTRACT | The present disclosure generally relates to, inter alia, a class of chimeric switch receptors containing an endodomain of an IL-9 receptor, engineered to modulate transcriptional regulation in a ligand-dependent manner. The disclosure also provides compositions and methods useful for producing such receptors, nucleic acids encoding same, host cells genetically modified with the nucleic acids, as well as methods for modulating gene expression, modulating an activity of a cell, and/or for the treatment of various health conditions or diseases. |
| FILED | Friday, September 16, 2022 |
| APPL NO | 17/946894 |
| CURRENT CPC | Peptides C07K 14/7155 (20130101) Original (OR) Class C07K 2319/03 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0634 (20130101) C12N 15/85 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230110342 | Zhao et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yangbing Zhao (Lumberton, New Jersey); Xiaojun Liu (Wallingford, Pennsylvania); Carl H. June (Merion Station, Pennsylvania) |
| ABSTRACT | The present invention includes a method for expanding a population of electroporated T cells. The method includes electroporating a population of cells comprising T cells with mRNA encoding a chimeric membrane protein comprising an antigen binding domain to a molecule and an intracellular domain of a co-stimulatory molecule, wherein the cultured T cells expand at least 10 fold. The invention further includes an expanded population of T cells, compositions comprising the cells and methods of treatment. |
| FILED | Wednesday, September 14, 2022 |
| APPL NO | 17/932188 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/02 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 48/00 (20130101) A61K 2035/124 (20130101) Peptides C07K 14/705 (20130101) C07K 14/7051 (20130101) C07K 14/7151 (20130101) C07K 14/70517 (20130101) C07K 14/70521 (20130101) C07K 14/70596 (20130101) C07K 16/30 (20130101) C07K 16/2809 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 2501/51 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230110354 | Rove et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a Body Corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jessica Anne Yu Rove (Aurora, Colorado); Dae Won Park (Englewood, Colorado); Adam J. Rocker (Broomfield, Colorado) |
| ABSTRACT | A novel therapeutic agent delivery system, methods of use and methods of formation thereof are presented. The novel delivery system is comprised of novel nanoparticles capable of at least partially encapsulating a therapeutic agent such as an anesthetic, antimicrobial, growth factor or protein. The nanoparticles are embedded with in a crosslinked hydrogel. The hydrogel can be administered directly to a patient or may be coated onto a device such as a catheter. The delivery system allows for a sustained release of the therapeutic agent over an extended period of time. |
| FILED | Tuesday, December 06, 2022 |
| APPL NO | 18/075627 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5138 (20130101) A61K 31/167 (20130101) Original (OR) Class Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 29/145 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230110385 | Wei et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION (SEOUL, South Korea); IT-UNIVERSITY OF COPENHAGEN (COPENHAGEN S, Denmark) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fang Wei (Northridge, California); Sarah Kamounah (Copenhagen S, Germany); Anne Marie Lynge Pedersen (Charlottenlund, Germany); Yeong Wook Song (Seoul, South Korea); David Chia (Santa Monica, California); David T. Wong (Beverly Hills, California) |
| ABSTRACT | A system and method for the detection of autoantibodies in saliva is described. In particular, the system is suitable for detecting an autoantibody in a subject, wherein the presence of the autoantibody is indicative of the presence or increased risk of development of an autoimmune disease or disorder. |
| FILED | Wednesday, March 03, 2021 |
| APPL NO | 17/905419 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/564 (20130101) Original (OR) Class G01N 33/5438 (20130101) G01N 2800/24 (20130101) G01N 2800/101 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230110411 | Leuthardt et al. |
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| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri); MUSC Foundation for Research Development (Charleston, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric C. Leuthardt (St. Louis, Missouri); Peter Brunner (St. Louis, Missouri); Kara Donovan (St. Louis, Missouri); Aiko Thompson (Charleston, South Carolina) |
| ABSTRACT | The present disclosure describes devices and methods for detecting motoneuron excitability in a subject in need. The method includes stimulating a cutaneous distribution of a patient’s vagus nerve within a patient’s ear with a nerve stimulating signal; detecting F-wave occurrence with an evoked electromyography paradigm; and adjusting one or more parameters of the nerve stimulating signal to change the F-wave occurrence. |
| FILED | Friday, September 30, 2022 |
| APPL NO | 17/936986 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0456 (20130101) A61N 1/36031 (20170801) Original (OR) Class A61N 1/36036 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230110440 | Wang et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Tza-Huei Jeff Wang (Germantown, Maryland); Kuangwen Hsieh (Baltimore, Maryland); Yi-Fan Frank Hsieh (New Taipei City, Taiwan); Aniruddha Mrithinjay Kaushik (Baltimore, Maryland); Fangchi Shao (Baltimore, Maryland); Pengfei Zhang (Baltimore, Maryland) |
| ABSTRACT | A tubing-free, sample-to-droplet microfluidic system includes a tubing-free, sample-to-droplet microfluidic chip; a valve control system connected to the tubing-free, sample-to-droplet microfluidic chip; a vacuum system fluidly connected to the tubing-free, sample-to-droplet microfluidic chip; and a droplet formation pressure system fluidly connected to the tubing-free, sample-to-droplet microfluidic chip. A microfluidic chip for a tubing-free, sample-to-droplet microfluidic system includes a tubing-free, sample-to-droplet interface section; a droplet mixing section in fluid connection with the tubing-free, sample-to-droplet interface section to received droplets therefrom; an incubation section in fluid connection with the droplet mixing section to receive droplets therefrom; and a detection section in fluid connection with the incubation section to receive droplets therefrom. |
| FILED | Tuesday, September 27, 2022 |
| APPL NO | 17/954000 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502738 (20130101) Original (OR) Class B01L 2300/0636 (20130101) B01L 2300/0883 (20130101) B01L 2400/02 (20130101) B01L 2400/049 (20130101) B01L 2400/0666 (20130101) Manipulators; Chambers Provided With Manipulation Devices B25J 9/1697 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230110556 | Herron et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Todd Herron (Ann Arbor, Michigan); Jiang Jiang (Ann Arbor, Michigan); Jose Jalife (Ann Arbor, Michigan) |
| ABSTRACT | Provided herein are systems and methods for electrically stimulating cultured cells, including cardiomyocytes. In particular, provided herein are systems and methods employing reusable electrode arrays with multiwell culture devices that provide electrical stimulation to cells that are cultured in individual wells of the devices. The technologies described may be used to stimulate cells for phenotype analysis. |
| FILED | Friday, November 11, 2022 |
| APPL NO | 17/985675 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/12 (20130101) C12M 35/02 (20130101) C12M 41/46 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0657 (20130101) Original (OR) Class C12N 2506/02 (20130101) C12N 2529/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230110567 | Straube et al. |
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| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tobias Straube (Durham, North Carolina); Stewart Farling (Durham, North Carolina); Bruce Klitzman (Durham, North Carolina); Marc Deshusses (Durham, North Carolina); Travis Vesel (Durham, North Carolina); Ira Cheifetz (Durham, North Carolina) |
| ABSTRACT | The present disclosure describes intravascular oxygenation systems and methods with one or more of improved oxygen diffusion flux, improved resistance to bubble formation on the surface of non-porous hollow fibers, and reduced size. The systems and methods include a pneumatic inlet coupled to a pneumatic source that provides a gas containing oxygen at a high pressure. A plurality of hollow fiber membranes (HFM) are in pneumatic communication with the pneumatic inlet to receive the gas containing oxygen and with an outlet to exhaust a partially deoxygenated gas. An electronic controller drives the motor to oscillate the plurality of HFMs to cause a diffusive flux of the gas containing oxygen from the plurality of HFMs into a region of interest of a subject. The electronic controller may drive the motor according to an oscillation pattern, which may include a macro-oscillation with superimposed micro-oscillations. |
| FILED | Monday, October 10, 2022 |
| APPL NO | 17/962966 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 60/13 (20210101) A61M 60/122 (20210101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230111070 | Xia et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE METHODIST HOSPITAL SYSTEM (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Jiong Xia (Houston, Texas); Jaime Gateno (Bellaire, Texas); Peng Yuan (Houston, Texas) |
| ABSTRACT | Systems and methods for orthognathic surgical planning are described herein. An example computer-implemented method can include generating a composite three-dimensional (3D) model of a subject's skull, defining a primal reference frame for the composite 3D model, performing a cephalometric analysis on the composite 3D model to quantify at least one geometric property of the subject's skull, performing a virtual osteotomy to separate the composite 3D model into a plurality of segments, performing a surgical simulation using the osteotomized segments, and designing a surgical splint or template for the subject. |
| FILED | Monday, December 12, 2022 |
| APPL NO | 18/079277 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 34/10 (20160201) A61B 34/20 (20160201) A61B 2034/102 (20160201) A61B 2034/105 (20160201) A61B 2034/107 (20160201) A61B 2034/2068 (20160201) Dentistry; Apparatus or Methods for Oral or Dental Hygiene A61C 13/0004 (20130101) Original (OR) Class A61C 13/0019 (20130101) Image Data Processing or Generation, in General G06T 7/0014 (20130101) G06T 2207/30036 (20130101) G06T 2207/30204 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230111075 | Janzen et al. |
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| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William Perry Janzen (Chapel Hill, North Carolina); Samantha Gail Pattenden (Mebane, North Carolina); Chatura Nadisha Jayakody (Morrisville, North Carolina); Jason Eric Streeter (Chapel Hill, North Carolina); Paul Alexander Dayton (Carrboro, North Carolina); Cameron Champion Wood (Raleigh, North Carolina); Siddharth Kaup Shenoy (Durham, North Carolina) |
| ABSTRACT | Methods and systems for using encapsulated microbubbles to process biological samples are disclosed. According to one aspect, a method for using encapsulated microbubbles to process a biological sample includes creating a mixture comprising encapsulated microbubbles mixed with a biological sample and adding activation energy to the mixture to cause at least some of the microbubbles to oscillate or burst and thereby process the sample, including effecting cell lysis, shearing DNA, and/or performing tissue dispersion. |
| FILED | Thursday, October 06, 2022 |
| APPL NO | 17/961538 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/10 (20130101) C12N 15/1003 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/38 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230111081 | Rogawski et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael A. Rogawski (Sacramento, California); Isaac N. Pessah (Davis, California); Zhengyu Cao (Woodland, California); Pamela J. Lein (Daivs, California) |
| ABSTRACT | Provided are compositions comprising a benzodiazepine and a neurosteroid, containing one or both of the benzodiazepine and the neurosteroid in a subtherapeutic dose, and administration of such compositions for mitigation of an epileptic seizure. Further provided are compositions comprising a benzodiazepine, a neurosteroid, and an NMDA blocker, and administration of such compositions for mitigation of an epileptic seizure. |
| FILED | Saturday, November 19, 2022 |
| APPL NO | 17/990661 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/57 (20130101) Original (OR) Class A61K 31/439 (20130101) A61K 31/5513 (20130101) A61K 31/5517 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/08 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230111083 | Gage et al. |
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| FUNDED BY |
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| APPLICANT(S) | SALK INSTITUTE FOR BIOLOGICAL STUDIES (La Jolla, California) |
| ASSIGNEE(S) | SALK INSTITUTE FOR BIOLOGICAL STUDIES (La Jolla, California) |
| INVENTOR(S) | Fred H. Gage (La Jolla, California); Dylan A. Reid (San Diego, California); Patrick J. Reed (San Diego, California) |
| ABSTRACT | Provided are methods for identification of DNA repair locations in a genome of a non-dividing cell, by incorporating a reactive nucleoside analogs into the genome of the non-dividing cell, then sequencing the regions of the genome that incorporated the nucleoside analog. |
| FILED | Monday, June 15, 2020 |
| APPL NO | 17/913352 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6883 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230111140 | Berta et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF CINCINNATI (Cincinnati, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Temugin Berta (Cincinnati, Ohio); Raquel Tonello (Cincinnati, Ohio) |
| ABSTRACT | The present invention involves a method of treating pain. The method treats a patient having post-operative pain or chemotherapy induced neuropathic pain, and it involves a) assessing the patient to determine if they are experiencing post-operative pain or chemotherapy induced neuropathic pain, and if such pain is diagnosed; b) administering to the patient a therapeutically effective amount of an agonist for the nuclear receptor subfamily 4, group A, member 1 (NR4A1). In one embodiment, the agonist is selected from the group consisting of Cytosporone B, Ethyl 2-[2,3,4-trimethoxy-6-(1-octanoyl)-phenyl] acetate (TMPA), 1,3,7-trihydroxy-2,4-diprenylxanthone (CCE9), 1-(3,4,5-trihydroxyphenyl)-nonan-1-one (THPN), DIM-C-pPhOCH3 (C-DIM-5), 1,1-bis(3′-indolyl)-1-(phenyl)methane (DIM-C-Ph) and 1,1-bis(3′-indolyl)-1-(p-anisyl)methane (DIM-C-pPhOCH3). |
| FILED | Monday, August 31, 2020 |
| APPL NO | 17/909513 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/121 (20130101) A61K 31/216 (20130101) Original (OR) Class A61K 31/337 (20130101) A61K 31/353 (20130101) A61K 31/404 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/02 (20180101) A61P 25/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230111302 | VLASOV et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yurii VLASOV (Urbana, Illinois); Christopher Kenji BRENDEN (Urbana, Illinois) |
| ABSTRACT | Provided are electrochemical sensors for analyzing analytes. The sensors may comprise an implantable probe for analyzing a biological analyte, with those sensors described as electrochemical biosensors. Also provided are related methods of using and making the sensors. The electrochemical sensor is formed with an integrated on-chip probe body that provides for a buried microelectrode in a microfluidic channel etched in the probe body, such as a doped Si substrate. The fluidic system can, therefore, be quite small and suitable for in-vivo implantation and use, while withstanding high pressure. The fluidic system has specially-configured reagent channel to provide for periodic and convenient calibration, electrode cleaning and/or regeneration, without having to remove any sensor component from the implantation site. |
| FILED | Friday, September 23, 2022 |
| APPL NO | 17/952057 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/14532 (20130101) Original (OR) Class A61B 5/14546 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5438 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230111402 | Ngwa |
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| FUNDED BY |
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| APPLICANT(S) | The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wilfred F. Ngwa (Framingham, Massachusetts) |
| ABSTRACT | Methods and systems for radiation therapy involve administering a payload / combination of biocompatible high-Z and semiconductor NPs to tissue, such as a tumor or an eye. Ionizing radiation may be directed towards the payload, and ionized electrons generate Cerenkov radiation (CR). The CR interacts with semiconductor NPs to produce chemical species that are damaging to cells. The payload may be administered via injection or via a radiotherapy (RT) device that includes NPs in a biodegradable polymer matrix. Biodegradation of the polymer matrix, which results in release of its payload, may be remotely activated using, for example, electromagnetic or sound waves. The payload may include one or more immunologic adjuvants capable of promoting an immunologic response at remote sites (such as a metastatic tumors) that are separate from the site at which the NPs and adjuvants were administered. |
| FILED | Monday, May 09, 2022 |
| APPL NO | 17/739803 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 41/0038 (20130101) Original (OR) Class A61K 41/0057 (20130101) A61K 47/6929 (20170801) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/00 (20130101) A61N 5/1001 (20130101) A61N 2005/1098 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230111409 | Walker et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Graham C. Walker (Cambridge, Massachusetts); Siva Sankari Iyer Mani Sankaran (Quincy, Massachusetts); Vigneshbabu Musuri Periasamy (Quincy, Massachusetts) |
| ABSTRACT | The disclosure provides heme binding peptides and their use for treating disorders that can benefit from sequestering free heme. |
| FILED | Wednesday, October 12, 2022 |
| APPL NO | 18/045914 |
| CURRENT CPC | Peptides C07K 14/21 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230111460 | Figueiredo |
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| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Marxa L. Figueiredo (Lafayette, Indiana) |
| ABSTRACT | The present invention generally relates to composition matters and methods useful for gene delivery and an option for therapeutic treatment of various diseases. Particularly, this disclosure relates to a plasmid vector comprising a fusion of a plurality of genes comprising a gene of a chemokine or a cytokine, a gene for a targeting polypeptide and genes for one or more polypeptide linkers. Methods of use and composition matters are within the scope of this disclosure. |
| FILED | Friday, January 01, 2021 |
| APPL NO | 17/794917 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 41/0047 (20130101) A61K 47/64 (20170801) A61K 47/6455 (20170801) A61K 48/0041 (20130101) A61K 48/0083 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/54 (20130101) Original (OR) Class C07K 2319/09 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230111697 | Christiano et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| INVENTOR(S) | Angela M. Christiano (Mahwah, New Jersey); Raphael Clynes (West Nyack, New York) |
| ABSTRACT | The invention provides for methods for treating a hair loss disorder in a subject by administering a Janus Kinase/Signal Transducers and Activators of Transcription inhibitor. |
| FILED | Wednesday, April 06, 2022 |
| APPL NO | 17/714964 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 8/41 (20130101) A61K 31/52 (20130101) Specific Use of Cosmetics or Similar Toilet Preparations A61Q 7/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230111712 | Jewett et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John C. Jewett (Tucson, Arizona); Garrett Davis (Tucson, Arizona); Holly Sofka (Tucson, Arizona) |
| ABSTRACT | Modular Meldrum's acid amine-reactive Michael acceptor (MaMa)—based molecules that are stable probes for high pH environents and bioconjugations. The molecules of the present invention can selectively label and protect lysine residues. In certain embodiments, the molecules can selectively react with lysine at particular pH levels. The probes of the present invention may be used to label proteins in a fluorescent manner, for purification, imaging, or general protein modifications, however the present invention is not limited to the aforementioned applications. |
| FILED | Monday, March 15, 2021 |
| APPL NO | 17/905787 |
| CURRENT CPC | Heterocyclic Compounds C07D 319/06 (20130101) Peptides C07K 1/13 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/533 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230111803 | Herold |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Albert Einstein College of Medicine (Bronx, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Betsy C. Herold (Rowayton, Connecticut) |
| ABSTRACT | Methods of treating or preventing ocular disease caused by herpes simplex virus-1 infection are provided, and comprise administering to a subject an effective amount of a herpes simplex virus-2 (HSV-2) having a deletion of an HSV-2 glycoprotein D-encoding gene in the genome to treat or prevent ocular disease in the subject, wherein the HSV-2 is phenotypically complemented with an HSV-1 glycoprotein D by propagating the HSV-2 in a complementing cell expressing the HSV-1 glycoprotein D. |
| FILED | Wednesday, April 07, 2021 |
| APPL NO | 17/913707 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/245 (20130101) Original (OR) Class A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230111917 | Knight et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zachary A. Knight (San Francisco, California); Beth Apsel (San Francisco, California); Kevan M. Shokat (San Francisco, California) |
| ABSTRACT | The present invention provides novel compounds that are antagonists of PI3 kinase, PI3 kinase and tyrosine kinase, PI3 kinase and mTOR, or PI33 kinase, mTOR and tyrosine kinase. |
| FILED | Thursday, March 31, 2022 |
| APPL NO | 17/709702 |
| CURRENT CPC | Heterocyclic Compounds C07D 471/04 (20130101) C07D 487/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230111954 | Kwong et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Gabriel A. Kwong (Atlanta, Georgia); Sangeeta N. Bhatia (Lexington, Massachusetts) |
| ABSTRACT | Some aspects of this invention provide reagents and methods for the sensitive, quantitative and simultaneous detection of target analytes in complex biological samples by liquid chromatography tandem mass spectrometry (LC MS/MS). Some aspects of this invention provide affinity reagents encoded with mass reporters for the sensitive and quantitative translation of an analyte of interest into a mass tag. The reagents and methods provided herein have general utility in analyte detection and encoding, for example, in biomolecular profiling, molecular diagnostics, and biochemical encoding. |
| FILED | Thursday, December 08, 2022 |
| APPL NO | 18/063162 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 7/08 (20130101) C07K 14/001 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/58 (20130101) Original (OR) Class G01N 33/6848 (20130101) G01N 2458/15 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230112136 | JORDA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cellphire, Inc. (Rockville, Maryland) |
| ASSIGNEE(S) | Cellphire, Inc. (Rockville, Maryland) |
| INVENTOR(S) | Rafael JORDA (Merignac, France); Anne S. Hale (Placitas, New Mexico); Braden Carl ISHLER (Montgomery Village, Maryland); Keith Andrew MOSKOWITZ (Westfield, Indiana) |
| ABSTRACT | The present disclosure provides dry and liquid compositions that include canine platelets and/or canine platelet-derived substances in dried form or rehydrated form from a dried form of canine platelets and/or canine platelet-derived substances, as well as processes for preparing such compositions. The disclosure also provides processes for making the compositions and methods of using the compositions for therapeutic, prophylactic, diagnostic, and research purposes, and kits comprising the compositions. |
| FILED | Friday, December 02, 2022 |
| APPL NO | 18/061359 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) A61K 9/0019 (20130101) A61K 9/19 (20130101) A61K 35/19 (20130101) Original (OR) Class A61K 47/26 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0644 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230112372 | Brown |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (WARF) (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Brown (Madison, Wisconsin) |
| ABSTRACT | A primatized rodent or swine, and methods of making and using the primatized rodent or swine, are provided. |
| FILED | Friday, September 02, 2022 |
| APPL NO | 17/929378 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0271 (20130101) A01K 67/0275 (20130101) Original (OR) Class A01K 2207/12 (20130101) A01K 2217/052 (20130101) A01K 2227/105 (20130101) A01K 2227/108 (20130101) A01K 2267/0387 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230112375 | Saggar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Manish Saggar (Stanford, California); Samir Chowdhury (Stanford, California); Caleb Geniesse (Stanford, California) |
| ABSTRACT | Embodiments herein describe systems and methods for scalable mapping of brain dynamics and uses thereof are provided. Many embodiments are capable of mapping brain dynamics in a computationally efficient way. In many embodiments, shape graphs can be produced which can operate as interactive network representations of dynamic brain activity data. Methods for automatically interpreting the structure of the shape graphs are described herein. In various embodiments, the mapped brain dynamics can be used to indicate which type of treatment protocol is likely to be most effective for the particular individual. In many embodiments, the treatment includes transcranial magnetic stimulation, pharmaceutical treatment, and/or any other mental condition treatment as appropriate to the requirements of specific applications of embodiments of the invention. |
| FILED | Tuesday, October 11, 2022 |
| APPL NO | 18/045772 |
| CURRENT CPC | Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/20 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230112505 | YADAV et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of South Florida (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hariom YADAV (Land O'Lakes, Florida); Shalini JAIN (Land O'Lakes, Florida); Sidharth MISHRA (Tampa, Florida) |
| ABSTRACT | Described are methods of treating neurodegenerative disease by administering a therapeutically effective amount of fenchol to a patient in need thereof. Additionally, described are methods of activating FFAR2 signaling in a patient by administering a therapeutically effective amount of fenchol to a patient in need thereof. Methods of treating gastrointestinal disorders in a patient being treated for cancer and methods of improving cognition in a patient being treated for cancer are also described. Further, the present disclosure provides for a pharmaceutical composition including fenchol and an Alzheimer's disease drug. Additionally, a nasal spray including fenchol, a buccal tablet including fenchol, and a dietary supplement including fenchol are described. |
| FILED | Friday, July 01, 2022 |
| APPL NO | 17/856400 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/006 (20130101) A61K 31/045 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230112565 | TAO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| INVENTOR(S) | Nongjian TAO (Scottsdale, Arizona); Shaopeng WANG (Chandler, Arizona); Pengfei ZHANG (Scottsdale, Arizona) |
| ABSTRACT | Detecting single molecules includes binding the single molecules to a surface of an optically transparent substrate, irradiating the surface of the substrate with light having an incident angle selected to achieve total reflection of the light, thereby scattering light from the surface and from the single molecules bound to the surface, and collecting light scatted by the surface and by the single molecules bound to the surface to form a series of images. Systems for detecting single molecules include an optically transparent substrate, a means for flowing a sample solution over a surface of the substrate, a light source configured to irradiate the surface, a camera, and a collection optical system configured to collect light scatted by the surface and by the target molecules on the surface to form a series of images on the camera. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/799230 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) B01L 2200/0652 (20130101) B01L 2300/12 (20130101) B01L 2300/0654 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1434 (20130101) G01N 33/6803 (20130101) Original (OR) Class G01N 33/54386 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230112568 | Guziewicz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karina E. Guziewicz (Broomall, Pennsylvania); Artur V. Cideciyan (Lafayette Hill, Pennsylvania); William A. Beltran (Wynnewood, Pennsylvania); Samuel G. Jacobson (Penn Valley, Pennsylvania); Gustavo D. Aguirre (, None) |
| ABSTRACT | Methods for treating bestrophinopathies are provided herein. The method includes, administering to an eye of the subject a dose of a recombinant adeno-associated virus (rAAV) vector comprising a nucleic acid sequence encoding a human BEST1 protein, wherein the subject has two mutant BEST1 alleles. Also provided are methods for evaluating treatments for retinal degeneration. |
| FILED | Sunday, February 28, 2021 |
| APPL NO | 17/904903 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/12 (20130101) A61B 3/102 (20130101) A61B 5/1075 (20130101) A61B 5/4058 (20130101) A61B 5/4848 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 38/177 (20130101) A61K 48/0058 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230112573 | BERTASSONI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | OREGON HEALTH and SCIENCE UNIVERSITY (Portland, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Luiz BERTASSONI (Portland, Oregon); Avathamsa ATHIRASALA (Portland, Oregon) |
| ABSTRACT | Biomaterials for tissue regeneration and engineering applications and methods of making and use thereof are described, as well as constructs and kits derived from the biomaterials. The biomaterials can be derived from extracellular matrix and functionalized to make them crosslinkable and amenable to tuning of their material properties. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/905147 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/16 (20130101) A61L 27/52 (20130101) A61L 27/3608 (20130101) Original (OR) Class A61L 27/3625 (20130101) A61L 27/3633 (20130101) A61L 27/3687 (20130101) A61L 27/3691 (20130101) A61L 27/3808 (20130101) A61L 27/3834 (20130101) A61L 2300/802 (20130101) A61L 2430/40 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 70/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230112800 | WILLIAMS, III et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas); TFF PHARMACEUTICALS, INC. (Fort Worth, Texas) |
| ASSIGNEE(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas); TFF PHARMACEUTICALS, INC. (Fort Worth, Texas) |
| INVENTOR(S) | Robert O. WILLIAMS, III (Austin, Texas); Zachary N. WARNKEN (Austin, Texas); Miguel O. Jara GONZALES (Austin, Texas); John J. KOLENG (Fort Worth, Texas) |
| ABSTRACT | The present disclosure provides pharmaceutical compositions of niclosamide that may be administered orally. These compositions may allow the achievement of a therapeutically effective dose of niclosamide while preventing crystallization in the stomach which reduces bioavailability. These compositions may be used to treat one or more diseases or disorders such as a viral infection or cancer. |
| FILED | Wednesday, August 31, 2022 |
| APPL NO | 17/823635 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/284 (20130101) Original (OR) Class A61K 9/2013 (20130101) A61K 9/2027 (20130101) A61K 9/2054 (20130101) A61K 9/2059 (20130101) A61K 9/2866 (20130101) A61K 31/167 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230112887 | Quave et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Emory University (Atlanta, Georgia); Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cassandra Quave (Atlanta, Georgia); Francois Chassagne (Atlanta, Georgia); Lewis Marquez (Atlanta, Georgia); Micah Dettweiler (Atlanta, Georgia); Julia Kubanek (Decatur, Georgia); Anne M. Sweeney-Jones (Atlanta, Georgia); Bhuwan Khatri Chhetri (Atlanta, Georgia) |
| ABSTRACT | This disclosure relates to pentagalloyl glucose compositions and uses in managing microbial infections and compositions related thereto. In certain embodiments, this disclosure relates to compositions of pentagalloyl glucose. In certain embodiments, this disclosure relates to methods of treating or preventing a microbial infection, e.g., an antimicrobial resistant microbial infection, comprising administering to a subject in need thereof an effective amount of pentagalloyl glucose or salt thereof. In certain embodiments, the microbe is bacteria or fungi resistant to one or more antibiotic agents or antifungal agents. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/802754 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7024 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) A61P 31/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230112888 | Canney et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Temple University-Of The Commonwealth System of Higher Education (Philadelphia, Pennsylvania); Praeventix, LLC (Exton, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel J. Canney (Ambler, Pennsylvania); Benjamin E. Blass (Eagleville, Pennsylvania); Kevin M. Blattner (Folsom, Pennsylvania); Douglas A. Pippin (Chester Springs, Pennsylvania) |
| ABSTRACT | Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity. |
| FILED | Thursday, March 31, 2022 |
| APPL NO | 17/709847 |
| CURRENT CPC | Heterocyclic Compounds C07D 221/00 (20130101) C07D 295/073 (20130101) C07D 309/08 (20130101) C07D 413/10 (20130101) C07D 491/107 (20130101) Original (OR) Class C07D 493/10 (20130101) C07D 513/04 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230113036 | SESSLER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan L. SESSLER (Austin, Texas); Jonathan ARAMBULA (Austin, Texas); Zahid H. SIDDIK (Houston, Texas); Gregory THIABAUD (Austin, Texas) |
| ABSTRACT | The present disclosure relates platinum(IV) and texaphyrin linked conjugates and compositions comprising a texaphyrin and a platinum(IV) agent. The present disclosure also provides pharmaceutical compositions of the conjugates and compositions. Also, provided herein are methods of using the instant compounds in the treatment of cancer such as a platinum resistant cancer. |
| FILED | Thursday, June 16, 2022 |
| APPL NO | 17/807245 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/555 (20130101) Original (OR) Class A61K 47/60 (20170801) A61K 47/546 (20170801) A61K 47/547 (20170801) A61K 49/10 (20130101) A61K 49/085 (20130101) A61K 49/106 (20130101) Heterocyclic Compounds C07D 487/22 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 15/0093 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230113073 | CLARK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edward CLARK (Seattle, Washington); Jay Wesley CHAPLIN (Seattle, Washington) |
| ABSTRACT | The present invention provides compositions of CD 180 targeting molecules coupled to heterologous antigens, and their use in treating and/or limiting disease. |
| FILED | Friday, December 09, 2022 |
| APPL NO | 18/063823 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/29 (20130101) A61K 39/385 (20130101) A61K 47/6811 (20170801) A61K 47/6849 (20170801) A61K 2039/55511 (20130101) Peptides C07K 16/2896 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230113085 | Wu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xu Wu (Lexington, Massachusetts); Pranab Maiti (Hyderabad, India); Chandrasekhar Abbineni (Hyderabad, India); Krishna Chaitanya Talluri (Hyderabad, India); Sunil Kumar Panigrahi (Boudh, India); Gopala Krishna Jarugumilli (Malden, Massachusetts); Yang Sun (Quincy, Massachusetts) |
| ABSTRACT | The present disclosure compounds, as well as their compositions and methods of use. The compounds inhibit the activity of the TEAD transcription factor, and are useful in the treatment of diseases related to the activity of TEAD transcription factor including, e.g., cancer and other diseases. |
| FILED | Friday, March 13, 2020 |
| APPL NO | 17/439735 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 211/55 (20130101) C07C 211/56 (20130101) C07C 229/44 (20130101) C07C 229/48 (20130101) C07C 229/58 (20130101) C07C 237/40 (20130101) C07C 255/58 (20130101) C07C 311/44 (20130101) Heterocyclic Compounds C07D 205/04 (20130101) C07D 207/16 (20130101) C07D 209/08 (20130101) C07D 211/62 (20130101) C07D 213/74 (20130101) C07D 213/80 (20130101) C07D 215/227 (20130101) C07D 231/56 (20130101) C07D 233/61 (20130101) C07D 235/18 (20130101) C07D 239/42 (20130101) C07D 241/28 (20130101) C07D 249/08 (20130101) C07D 275/06 (20130101) C07D 295/135 (20130101) C07D 317/32 (20130101) C07D 401/06 (20130101) C07D 401/12 (20130101) C07D 471/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230113170 | Graham et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human (Bethesda, Maryland); Board of Regents, The University of Texas System (Austin, Texas); Trustees of Dartmouth College (Hanover, New Hampshire) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human (Bethesda, Maryland); Board of Regents, The University of Texas System (Austin, Texas); Trustees of Dartmouth College (Hanover, New Hampshire) |
| INVENTOR(S) | Barney Graham (Smyma, Georgia); Kizzmekia Corbett (Bethesda, Maryland); Olubukola Abiona (University Park, Maryland); Geoffrey Hutchinson (Rockville, Maryland); Jason McLellan (Austin, Texas); Daniel Wrapp (Austin, Texas); Nianshuang Wang (Austin, Texas) |
| ABSTRACT | SARS-CoV-2 S ectodomain trimers stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the SARS-CoV-2 S ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to SARS-CoV-2 S in a subject, for example, an immune response that inhibits SARS-CoV-2 infection in the subject. |
| FILED | Thursday, February 11, 2021 |
| APPL NO | 17/798021 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) A61K 39/215 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2770/20034 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230113363 | Safe et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TEXAS A&M UNIVERSITY SYSTEM (College Station, Texas) |
| ASSIGNEE(S) | THE TEXAS A&M UNIVERSITY SYSTEM (College Station, Texas) |
| INVENTOR(S) | Stephen Safe (Tamu College Station, Texas); Kumaravel Mohankumar (Tamu College Station, Texas) |
| ABSTRACT | Methods of treating endometriosis through modulation of Nuclear Receptor Subfamily 4 Group A Member 1 (NR4A1) activity including administration of an NR4A1 ligand to an individual in need thereof are described. In an embodiment, the compounds include methylene substituted diindolylmethanes. |
| FILED | Wednesday, February 24, 2021 |
| APPL NO | 17/904814 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/404 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 15/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230113477 | Genin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri); Columbia University (New York, New York) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri); Columbia University (New York, New York) |
| INVENTOR(S) | Guy Genin (St. Louis, Missouri); Ethan Hoppe (St. Louis, Missouri); Dong Hwan Yoon (St. Louis, Missouri); Stavros Thomopoulos (New York, New York); Iden Kurtaliaj (New York, New York); Liana Tedesco (New York, New York); David Kovacevic (New York, New York); Victor Birman (St. Louis, Missouri); Lester Smith (Indianapolis, Indiana); Leesa Galatz (St. Louis, Missouri); William Levine (New York, New York) |
| ABSTRACT | Devices and methods for joining a first and second tissue in a patient are disclosed that include a base with opposed first and second surfaces, and a plurality of recurved tines oriented to a tine axis and extending from the first surface of the base. The base defines four suture holes extending through the first and second surfaces of the base and configured to receive at least one suture passing between the first and second surfaces of the base. The plurality of recurved tines provides unidirectional traction of the first tissue along the tine axis toward the first surface to secure the device to the first tissue. The device is secured to the second tissue at the second surface with the at least one suture secured to at least one anchor secured to the second tissue. |
| FILED | Wednesday, September 14, 2022 |
| APPL NO | 17/932232 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/0401 (20130101) Original (OR) Class A61B 2017/0412 (20130101) A61B 2017/0414 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230113546 | Capobianco et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF MIAMI (Miami, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anthony J. Capobianco (Miami Beach, Florida); Stephan C Schúrer (Coral Gables, Florida); Xiaoxia Zhu (Palmetto Bay, Florida); Tanya T.. Kelley (Miami, Florida) |
| ABSTRACT | Disclosed herein are Notch transcriptional activation complex kinase (“MACK”) inhibitors, and methods for their use in treating or preventing diseases, such as cancer. The inhibitors described herein include compounds of Formula (Ia) and pharmaceutically acceptable salts thereof: wherein the substituents are as described. |
| FILED | Tuesday, September 06, 2022 |
| APPL NO | 17/929957 |
| CURRENT CPC | Heterocyclic Compounds C07D 231/54 (20130101) Original (OR) Class Enzymes C12Y 207/00 (20130101) C12Y 306/01003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20230113588 — METABOTROPIC GLUTAMATE RECEPTOR NEGATIVE ALLOSTERIC MODULATORS (NAMS) AND USES THEREOF
| US 20230113588 | COSFORD et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sanford Burnham Prebys Medical Discovery Institute (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas David Peter COSFORD (San Diego, California); Dhanya RAVEENDRA-PANICKAR (San Diego, California); Douglas J. SHEFFLER (San Diego, California); John Howard HUTCHINSON (San Diego, California); Reto Andreas GADIENT (San Diego, California) |
| ABSTRACT | Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor negative allosteric modulators (NAMs), compositions comprising the compounds, and methods of using the compounds and compositions. |
| FILED | Monday, August 08, 2022 |
| APPL NO | 17/883255 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/426 (20130101) A61K 31/427 (20130101) A61K 31/433 (20130101) A61K 31/505 (20130101) A61K 31/506 (20130101) A61K 31/4196 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) Heterocyclic Compounds C07D 217/06 (20130101) C07D 231/12 (20130101) C07D 233/54 (20130101) C07D 233/64 (20130101) C07D 239/26 (20130101) C07D 243/12 (20130101) C07D 243/14 (20130101) Original (OR) Class C07D 249/08 (20130101) C07D 261/08 (20130101) C07D 263/32 (20130101) C07D 271/06 (20130101) C07D 275/02 (20130101) C07D 277/20 (20130101) C07D 277/26 (20130101) C07D 277/30 (20130101) C07D 285/08 (20130101) C07D 307/38 (20130101) C07D 333/24 (20130101) C07D 401/04 (20130101) C07D 401/10 (20130101) C07D 401/12 (20130101) C07D 401/14 (20130101) C07D 403/10 (20130101) C07D 403/12 (20130101) C07D 405/04 (20130101) C07D 405/10 (20130101) C07D 409/02 (20130101) C07D 409/04 (20130101) C07D 409/14 (20130101) C07D 413/04 (20130101) C07D 413/14 (20130101) C07D 417/04 (20130101) C07D 417/10 (20130101) C07D 417/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230113802 | Ho et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Rodney J.Y. Ho (Seattle, Washington); James Griffin (Seattle, Washington); Qingxin Mu (Seattle, Washington); Yan Wu (Seattle, Washington); Jesse Yu (Seattle, Washington) |
| ABSTRACT | The present disclosure describes an injectable aqueous dispersion, including an aqueous solvent, and a chemotherapeutic agent composition dispersed in the aqueous solvent to provide the injectable aqueous dispersion. The chemotherapeutic agent composition includes a combination of chemotherapeutic agents selected from: gemcitabine and paclitaxel; and venetoclax and zanubrutinib. The chemotherapeutic agent composition further includes one or more compatibilizers comprising a lipid (e.g., a lipid excipient), a lipid conjugate, or a combination thereof. The chemotherapeutic agents of the chemotherapeutic agent composition exhibit a synergistic chemotherapeutic effect. |
| FILED | Thursday, February 25, 2021 |
| APPL NO | 17/904907 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/337 (20130101) A61K 31/519 (20130101) A61K 31/635 (20130101) A61K 31/7068 (20130101) Original (OR) Class A61K 47/24 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 35/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230113944 | John et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Varghese John (Los Angeles, California); Tina Bilousova (Santa Monica, California); Bryan Simmons (Santa Clarita, California); Neil Garg (Los Angeles, California); Jesus Campagna (Playa Del Rey, California); Barbara Jagodzinska (Redwood City, California) |
| ABSTRACT | Provided herein are compounds of Formula I and their salts, and compositions thereof that are useful for useful for modulating neutral sphingomyelinase 2 (n-SMase2) and/or acetylcholinesterase (AChE) in cells. Also disclosed herein are methods of using the disclosed compounds and compositions for inhibiting the spread of Tau seeds from donor cells to recipient cells. Further disclosed herein are methods of using the disclosed compounds and compositions for treating or preventing a neurodegenerative disorder, such as a tauopathy, Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), Lewy body dementia, frontotemporal dementia, and amyotrophic lateral sclerosis (ALS). |
| FILED | Friday, January 08, 2021 |
| APPL NO | 17/790407 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) A61P 27/06 (20180101) Heterocyclic Compounds C07D 491/048 (20130101) C07D 491/147 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230114119 | PETERS |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph E. PETERS (Ithaca, New York) |
| ABSTRACT | Provided are compositions, methods, systems, and kits, for use in CRISPR-based DNA editing. The compositions include RNA polynucleotides that include one or more atypical repeats, and can include truncated spacers. The RNA polynucleotides are used with proteins in systems that include CRISPR and transposon genes, or proteins encoded by the genes. The genes include transposon genes tnsA, tnsB, tnsC, and tniQ, and Cas genes cas8f, cas5f, cas7f, and cas6f. Use of the RNA polynucleotides as guide RNAs that include atypical repeats with the transposon and CRISPR proteins exhibit enhanced transposition, relative to guide RNAs that do not include atypical repeats. Enhanced transposition is demonstrated using representative IF-3b systems. |
| FILED | Tuesday, March 16, 2021 |
| APPL NO | 17/906134 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 15/1089 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230114130 | Babich et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Comell University (Ithaca, New York) |
| ASSIGNEE(S) | Comell University (Ithaca, New York) |
| INVENTOR(S) | John W. Babich (New York, New York); James M. Kelly (New York, New York); Alejandro Amor-Coarasa (Ithaca, New York); Shashikanth Ponnaia (New York, New York) |
| ABSTRACT | The present technology provides compounds, as well as compositions including such compounds, useful for imaging and/or treatment of a glioma, a breast cancer, an adrenal cortical cancer, a cervical carcinoma, a vulvar carcinoma, an endometrial carcinoma, a primary ovarian carcinoma, a metastatic ovarian carcinoma, a non-small cell lung cancer, a small cell lung cancer, a bladder cancer, a colon cancer, a primary, gastric adenocarcinoma, a primary colorectal adenocarcinoma, a renal cell carcinoma, and/or a prostate cancer. The compounds are represented by the following formula or a pharmaceutically acceptable salt thereof. |
| FILED | Tuesday, March 22, 2022 |
| APPL NO | 17/700913 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 51/065 (20130101) Original (OR) Class A61K 51/0402 (20130101) A61K 51/0497 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) General Methods of Organic Chemistry; Apparatus Therefor C07B 59/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230114205 | Bressler et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Boston University (Boston, Massachusetts); The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | Trustees of Boston University (Boston, Massachusetts); The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Eric M. Bressler (Allston, Massachusetts); Sarah Adams (Brighton, Massachusetts); Yolonda Colson (Dover, Massachusetts); Mark W. Grinstaff (Brookline, Massachusetts); Wilson Wai Chun Wong (Brookline, Massachusetts) |
| ABSTRACT | The present disclosure generally relates to compositions and method for delivery, e.g., sustained delivery of active agents, and their use for the treatment of diseases or disorders. |
| FILED | Friday, October 07, 2022 |
| APPL NO | 17/962149 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/70 (20130101) Original (OR) Class A61K 47/10 (20130101) A61K 47/34 (20130101) A61K 47/36 (20130101) A61K 47/64 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230114207 | Gray et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts); New York University (New York, New York) |
| ASSIGNEE(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts); New York University (New York, New York) |
| INVENTOR(S) | Nathanael S. Gray (Boston, Massachusetts); Kwok-kin Wong (Arlington, Massachusetts); Hua Zhang (New York, New York); Camilla Laulund Christensen Ross (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure provides methods and compositions related to combination therapy of a CDK7 inhibitor and immunotherapy. The combination of the CDK7 inhibitor and immunotherapy is useful in treating and/or preventing cancer in a subject. The combination therapy may further comprise chemotherapy (e.g., chemotherapeutic agents). |
| FILED | Wednesday, December 16, 2020 |
| APPL NO | 17/789047 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4162 (20130101) Original (OR) Class A61K 31/7048 (20130101) A61K 33/243 (20190101) A61K 39/3955 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230114264 | Cheng et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Jackson Laboratory (Bar Harbor, Maine); The Chinese University of Hong Kong (Hong Kong Sar, China PRC) |
| ASSIGNEE(S) | The Jackson Laboratory (Bar Harbor, Maine); The Chinese University of Hong Kong (Hong Kong Sar, China PRC) |
| INVENTOR(S) | Albert Cheng (Bar Harbor, Maine); Kwok Wai Lo (Hong Kong Sar, China PRC); Pok Man Tom Hau (Hong Kong Sar, China PRC); Man Wu (Hong Kong Sar, China PRC) |
| ABSTRACT | The present disclosure provides methods of inducing EBV early lytic cycle genes with high specificity. These methods slow or stop cancer cell growth in vitro and in vivo. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/802751 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/522 (20130101) A61K 38/465 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/85 (20130101) C12N 15/635 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2800/80 (20130101) C12N 2800/107 (20130101) C12N 2830/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230114365 | Tsui et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Memorial Sloan Kettering Cancer Center (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wai Yi Tsui (New York, New York); Francesco Marass (New York, New York); Luis Diaz, JR. (New York, New York) |
| ABSTRACT | The genomic data processing systems and methods described herein can accurately detect mutations in nucleic acid (e.g., cell free DNA (cfDNA) sequence reads associated with plasma nucleic acid samples. The genomic data processing system of the present disclosure distinguishes mutations derived from a tumor from mutations derived of clonal hematopoietic (CH) origin. The origin of mutated DNA fragments can be more accurately determined by analyzing fragment sizes in cfDNA to generate tumor and CH regions of interest (ROIs) in corresponding size profiles. A mutation can be more accurately classified using a metric based on proportions of fragments in the ROIs. |
| FILED | Thursday, March 18, 2021 |
| APPL NO | 17/914731 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) Original (OR) Class G16B 40/20 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230114408 | BANSAL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shyam S. BANSAL (Lewis Center, Ohio); Richard Joseph GUMINA (Columbus, Ohio) |
| ABSTRACT | Disclosed are method of modulating immune response in a subject using ERβ agonists. The ERβ agonists can selectively inhibit the activation and/or proliferation of T-cells, reducing circulating T-cell Levels in a subject without significantly affecting circulating levels of neutrophils, monocytes, or B-cells. As a result, the ERβ agonists can be used in therapeutic and/or prophylactic applications, including to treat or prevent chronic heart failure (CHF) in a subject post-myocardial infarction (MI) and to treat or prevent graft-versus-host disease (GVHD), multiple sclerosis (MS), and/or experimental autoimmune encephalomyelitis (EAE) in a subject. |
| FILED | Thursday, March 11, 2021 |
| APPL NO | 17/910158 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/05 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230114498 | NJAR et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MARYLAND, Baltimore (Baltimore, Maryland) |
| ASSIGNEE(S) | UNIVERSITY OF MARYLAND, Baltimore (Baltimore, Maryland) |
| INVENTOR(S) | Vincent C.O. NJAR (Glen Burnie, Maryland); Senthilmurugan RAMALINGAM (Ellicott City, Maryland); Lalji K. GEDIYA (Rockville, Maryland); Hannah W. MBATIA (Cary, North Carolina); Vidya P. RAMAMURTHY (Ellicott City, Maryland) |
| ABSTRACT | Novel retinamides with unique properties and biological activities, including inhibition of retinoic acid metabolism and modulation of Mnk1/2-eIF4E and androgen receptor (AR) signaling pathways, are synthesized and developed. The novel retinamides are capable of effecting treatment of a variety of dermatological conditions while limiting adverse side effects. |
| FILED | Friday, December 18, 2020 |
| APPL NO | 17/787065 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/00 (20180101) Heterocyclic Compounds C07D 233/56 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230114648 | Reed et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Jess Dreher Reed (Madison, Wisconsin); Dhanansayan Shanmuganayagam (Madison, Wisconsin); Christian Gerald Krueger (Cambridge, Wisconsin); Kenneth Allan Kudsk (Madison, Wisconsin); Joseph Francis Pierre (Chicago, Illinois); Aaron F. Heneghan (Middleton, Wisconsin); Rodrigo P. Feliciano (Düsseldorf, Germany) |
| ABSTRACT | Tannin-containing compositions and methods of using same to enhance or maintain immune function during simplified nutrition feeding. Pharmaceutical compositions, including enteral nutrition compositions, are provided. The compositions comprise such tannins as proanthocyanidins and/or hydrolysable tannins. Administering the tannins to the gastrointestinal tract of a subject receiving simplified nutrition, such as with enteral nutrition therapy or parenteral nutrition therapy, attenuates or prevents deleterious effects on the gastrointestinal immune system that would otherwise occur with the simplified nutrition. |
| FILED | Friday, December 02, 2022 |
| APPL NO | 18/073632 |
| CURRENT CPC | Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 33/10 (20160801) A23L 33/17 (20160801) A23L 33/40 (20160801) A23L 33/115 (20160801) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0029 (20130101) A61K 31/353 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230114726 | Lentzsch |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Suzanne Lentzsch (Bronx, New York) |
| ABSTRACT | Methods and pharmaceutical compositions for treatment of amyloid deposition diseases using chimeric (e.g., mouse-human) antibody are disclosed, including a method for treating amyloid deposition diseases with cardiac involvement by administering pharmaceutical compositions comprising a chimeric anti-amyloid fibril antibody. The methods herein can improve myocardial function in patients diagnosed with light chain amyloid light chain amyloidosis (ALA) having a cardiac involvement in as little as three weeks after treatment. |
| FILED | Tuesday, July 12, 2022 |
| APPL NO | 17/862626 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/3955 (20130101) Original (OR) Class A61K 39/39541 (20130101) A61K 2039/58 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 43/00 (20180101) Peptides C07K 16/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230114728 | BURNS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Venatorx Pharmaceuticals, Inc. (Malvem, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher J. BURNS (Malvern, Pennsylvania); Denis DAIGLE (Street, Maryland); Guo-Hua CHU (Exton, Pennsylvania); Jodie HAMRICK (New Holland, Pennsylvania); Steven A. BOYD (Chester Springs, Pennsylvania); Allison L. ZULLI (Chesterbrook, Pennsylvania); Stephen M. CONDON (Glenmoore, Pennsylvania); Cullen L. MYERS (Phoenixville, Pennsylvania); Zhenrong XU (Chalfont, Pennsylvania); Tsuyoshi Uehara (Berwyn, Pennsylvania); Nathan LINE (Royersford, Pennsylvania) |
| ABSTRACT | Described herein are certain boron-containing compounds, compositions, preparations and their use as modulators of the transpeptidase function of bacterial penicillin-binding proteins and as antibacterial agents. In some embodiments, the compounds described herein inhibit penicillin-binding proteins. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections. |
| FILED | Thursday, September 24, 2020 |
| APPL NO | 17/779804 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/20 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230114739 | Bajaj |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Father Flanagan's Boys' Home Doing Business as Boys Town National Research Hospital (Omaha, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sahil Bajaj (Boys Town, Nebraska) |
| ABSTRACT | A machine learned model has been trained using structural brain data obtained from parcellated brain images. The brain data is used to train the model to identify classifiers associated with biomarkers of specific regions of the brain. The biomarkers indicate the presence and/or potential for one or more mental conditions, such as the potential for suicide risk. Using the trained model, clinics, hospitals, and other locations will be able to quickly and accurately determine the potential for mental conditions, which can aid in identifying treatment for patients. The results can provide a prognosis for the mental condition as well. |
| FILED | Thursday, October 06, 2022 |
| APPL NO | 17/938538 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 20/10 (20190101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230114825 | Baker et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Baker (Seattle, Washington); Derrick Hicks (Seattle, Washington) |
| ABSTRACT | Polypeptides including an amino acid sequence at least 50% identical to the amino acid sequence selected from the group consisting of SEQ ID NOS: 1-3297 are provided, which are capable of forming protein homodimers containing tunable symmetric pockets. |
| FILED | Friday, October 07, 2022 |
| APPL NO | 17/938752 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/47 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230114946 | HELLER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Memorial Sloan Kettering Cancer Center (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel A. HELLER (New York, New York); Ryan M. WILLIAMS (New York, New York) |
| ABSTRACT | A drug carrier nanoparticle has been synthesized that can specifically target the proximal tubules of the kidneys. The nanoparticles accumulate in the kidneys to a greater extent than other organs (e.g., up to 3 or more times greater in the kidney than any other organ). They can encapsulate many classes of drug molecules. The nanoparticles are biodegradable and release the drug as they degrade. The particles can sustainably release a drug within the kidneys for up to two months. The nanoparticles are useful for the treatment of diseases that affect the proximal tubules, such as heart failure, liver cirrhosis, hypertension, and renal failure; the study of relative blood flow to the renal cortex and medulla; and delivery of agents to treat gout. |
| FILED | Friday, May 20, 2022 |
| APPL NO | 17/749902 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/5115 (20130101) A61K 9/5123 (20130101) A61K 9/5146 (20130101) A61K 9/5153 (20130101) Original (OR) Class A61K 9/5169 (20130101) A61K 31/40 (20130101) A61K 31/167 (20130101) A61K 31/192 (20130101) A61K 31/277 (20130101) A61K 31/404 (20130101) A61K 31/517 (20130101) A61K 31/519 (20130101) A61K 31/704 (20130101) A61K 31/4406 (20130101) A61K 31/4412 (20130101) A61K 31/4439 (20130101) A61K 31/4709 (20130101) A61K 31/4985 (20130101) A61K 47/6937 (20170801) A61K 49/0004 (20130101) A61K 49/0032 (20130101) A61K 49/0093 (20130101) A61K 51/1244 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 13/12 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230114971 | Leen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Baylor College of Medicine (Houston, Texas); Wilson Wolf Manufacturing (New Brighton, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ann Marie Leen (Houston, Texas); Ulrike Gerdemann (Cambridge, Massachusetts); Cliona M. Rooney (Bellaire, Texas); Juan F. Vera Valdes (Houston, Texas); John R. Wilson (New Brighton, Minnesota) |
| ABSTRACT | The present invention encompasses methods and compositions for the generation and use of cytotoxic T lymphocytes that target multiple viruses or that are specific for multiple tumor antigens. In specific embodiments, the generation methods employ use of certain cytokines to promote proliferation and reduce cell death in an activated T cell population and/or that employ a particular bioreactor having a gas permeable membrane. |
| FILED | Tuesday, December 06, 2022 |
| APPL NO | 18/062452 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) A61K 39/12 (20130101) A61K 39/155 (20130101) A61K 39/245 (20130101) A61K 2039/54 (20130101) A61K 2039/572 (20130101) A61K 2039/5158 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 5/0638 (20130101) Original (OR) Class C12N 2501/23 (20130101) C12N 2501/2302 (20130101) C12N 2501/2306 (20130101) C12N 2501/2307 (20130101) C12N 2501/2312 (20130101) C12N 2501/2315 (20130101) C12N 2502/11 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230115330 | Hermosillo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| INVENTOR(S) | Robert Jeremiah Matthias Hermosillo (Minneapolis, Minnesota); Damien A. Fair, III (Minneapolis, Minnesota); Eric Feczko (Minneapolis, Minnesota); Lucille Anne Moore (Minneapolis, Minnesota); Óscar Miranda-Domínguez (Minneapolis, Minnesota) |
| ABSTRACT | Functional networks are mapped for individuals and group populations based on magnetic resonance imaging, and the resulting functional mapping data (e.g., probabilistic maps of functional networks and/or integration zones where multiple functional networks overlap and/or interact) are used to guide or otherwise monitor the delivery of neuromodulation therapies. Individual-specific functional network maps can be generated based on an overlapping template matching that is capable of assigning multiple networks to a given grayordinate. |
| FILED | Monday, October 10, 2022 |
| APPL NO | 17/963009 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0042 (20130101) A61B 5/055 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/36025 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230115335 | Aguilera et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Renato J. Aguilera (El Paso, Texas); Subhas S. Karki (El Paso, Texas); Sujeet Kumar (El Paso, Texas); Manuel L. Penichet (Los Angeles, California) |
| ABSTRACT | The inventors have used a differential nuclear staining (DNS) assay to discover compounds with cytotoxic activity against the CEM cell line that has been determined to be highly sensitive to a variety of anti-cancer compounds. Compounds were synthesized based on a pyrazole backbone structure. Several newly synthesized compounds have been tested to identify the compounds with highest activity. One compound identified is the SSK-3 compound which has been tested on cancer cell lines and determined that it induced apoptosis via phosphatidylserine membrane exposure and activation of caspase 3 in the CEM lymphoma cell line. |
| FILED | Wednesday, October 12, 2022 |
| APPL NO | 17/964110 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/416 (20130101) A61K 31/454 (20130101) A61K 31/4192 (20130101) A61K 31/5377 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 35/02 (20180101) Heterocyclic Compounds C07D 231/54 (20130101) C07D 403/12 (20130101) Original (OR) Class C07D 405/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230115366 | Nathanson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David A. Nathanson (Los Angeles, California); Michael E. Jung (Los Angeles, California); Jonathan Tsang (Los Angeles, California); Lorenz Urner (Los Angeles, California); Peter M. Clark (Los Angeles, California); Timothy F. Cloughesy (Calabasas, California); Gyudong Kim (Seoul, South Korea) |
| ABSTRACT | The present disclosure relates to compounds that are capable of penetrating the blood brain barrier to modulate the activity of EGFR tyrosine kinase. The disclosure further relates to methods of treating glioblastoma and other EGFR-mediated cancers, such as those that have been determined to have altered glucose metabolism in the presence of inhibitors. The present disclosure also provides methods of administering to a subject a glucose metabolism inhibitor and a cytoplasmic p53 stabilizer. |
| FILED | Wednesday, June 29, 2022 |
| APPL NO | 17/853573 |
| CURRENT CPC | General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/05 (20130101) Heterocyclic Compounds C07D 239/94 (20130101) C07D 239/95 (20130101) C07D 405/04 (20130101) C07D 491/056 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230115651 | SLUSHER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland); INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY AS CR v.v.i. (PRAGUE, Czech Republic) |
| ASSIGNEE(S) | |
| INVENTOR(S) | BARBARA SLUSHER (KINGSVILLE, Maryland); RANA RAIS (KINGSVILLE, Maryland); MARCELA KRECMEROVA (PRAGUE, Czech Republic); TOMAS TICHY (PRAGUE, Czech Republic); PAVEL MAJER (SYKESVILLE, Maryland); ANDREJ JANCARIK (KOPRIVNICE, Czech Republic) |
| ABSTRACT | Methods and compounds are disclosed for treating a disease or condition by inhibiting PSMA (Prostate Specific Membrane Antigen) using prodrugs of 2-PMPA |
| FILED | Monday, May 09, 2022 |
| APPL NO | 17/739669 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/3808 (20130101) C07F 9/4006 (20130101) C07F 9/4075 (20130101) C07F 9/4084 (20130101) C07F 9/4087 (20130101) C07F 9/4465 (20130101) C07F 9/65586 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230115837 | COSFORD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sanford Burnham Prebys Medical Discovery Institute (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas David Peter COSFORD (San Diego, California); Dominik HEIMANN (Hamm, Germany); Peter TERIETE (San Diego, California); Sumit Kumar CHANDA (La Jolla, California); Lars PACHE (San Diego, California); Nicole BATA (San Diego, California) |
| ABSTRACT | Provided herein are compounds that modulate the activity of inhibitor of apoptosis (IAPs) proteins, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds. |
| FILED | Friday, November 06, 2020 |
| APPL NO | 17/773749 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/55 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230116062 | Markowitz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio); BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Dallas, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sanford Markowitz (Pepper Pike, Ohio); Amar Desai (Cleveland, Ohio); Joseph Ready (Carrollton, Texas) |
| ABSTRACT | A method of modulating hematopoietic stem cells and hematopoiesis includes administering to a subject in need thereof a 15-PGDH inhibitor. |
| FILED | Tuesday, August 30, 2022 |
| APPL NO | 17/898776 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/444 (20130101) A61K 31/495 (20130101) A61K 31/496 (20130101) A61K 31/519 (20130101) A61K 31/4365 (20130101) Original (OR) Class A61K 31/5377 (20130101) A61K 38/193 (20130101) A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230116191 | Anseth et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a body (Denver, California) |
| ASSIGNEE(S) | The Regents of the University of Colorado, a body (Denver, Colorado) |
| INVENTOR(S) | Kristi Anseth (Boulder, Colorado); Kemal Arda Gunay (Boulder, Colorado); Laura J. Macdougall (Boulder, Colorado) |
| ABSTRACT | Compositions and methods for preparing and using a swellable polymer network for expansion microscopy (ExM) applications. The swellable polymer network can be prepared on demand using external stimuli for ExM applications. A variety of external stimuli can be employed, including light irradiation, pH, temperature, and magnetic fields. Network preparation using light irradiation is particularly advantageous, as it allows tuned control over the network properties through the variation of time and dose of light irradiation. In other words, light irradiation can be employed with a wavelength and intensity that enables a polymer network formation. |
| FILED | Wednesday, March 10, 2021 |
| APPL NO | 17/906104 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 2/50 (20130101) C08F 290/062 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/30 (20130101) Original (OR) Class G01N 2001/305 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230116264 | Basmajian et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Baebies, Inc. (Durham, North Carolina) |
| ASSIGNEE(S) | Baebies, Inc. (Durham, North Carolina) |
| INVENTOR(S) | Michael A. Basmajian (Durham, North Carolina); Michael Boso (Durham, North Carolina); Vijay SRINIVASAN (Durham, North Carolina); Vamsee PAMULA (Durham, North Carolina) |
| ABSTRACT | Coagulation assays for a point-of-care platform is disclosed. For example, the disclosure provides methods of measuring viscoelastic properties in a droplet on a microfluidics device, including using electrowetting-mediated droplet operations on the microfluidics device. In some embodiments, a microfluidics point-of-care platform may be used for assaying and/or monitoring coagulation of a blood sample. The disclosure provides a system, digital microfluidics device, and methods for measuring coagulation of a blood sample. In various embodiments, the disclosure provides a microfluidics device including droplets subject to manipulation by the device wherein droplet movement is used to characterize coagulation of a blood sample. |
| FILED | Monday, October 10, 2022 |
| APPL NO | 17/962919 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502792 (20130101) B01L 2300/087 (20130101) B01L 2400/0427 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/4905 (20130101) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230116588 | Sevenler et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trustees of Boston University (Boston, Massachusetts) |
| ASSIGNEE(S) | Trustees of Boston University (Boston, Massachusetts) |
| INVENTOR(S) | Derin Sevenler (Boston, Massachusetts); M. Selim Ünlü (Newton Highlands, Massachusetts) |
| ABSTRACT | Herein is described kinetic assay, in which individual binding events are detected and monitored during sample incubation. This method uses interferometric reflectance imaging to detect thousands of individual binding events across a multiplex solid phase sensor with a large area. A dynamic tracking procedure is used to measure the duration of each event. From this, the total rates of binding and de-binding as well as the distribution of binding event durations are determined. Systems and components for performing the kinetic assay are also described. |
| FILED | Wednesday, December 07, 2022 |
| APPL NO | 18/076940 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/569 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 7/0012 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230116627 | HAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Renzhi HAN (Columbus, Ohio); Li XU (Bedford, Massachusetts); Yandi GAO (Powell, Ohio) |
| ABSTRACT | The present disclosure relates to nucleobase editors and methods of use thereof. Disclosed herein are fusion proteins, systems, and compositions for editing disease-associated mutations and methods of use thereof. In some aspects, disclosed herein is a fusion protein comprising a Cas9 nickase and a nucleotide deaminase, wherein the Cas9 nickase comprises a first amino acid substitution at a position selected from the group consisting of 262, 324, 409, 480, 543, 694, and 1219 when compared to SEQ ID NO: 11, and wherein the Cas9 nickase comprises a second amino acid substitution at a position selected from the group consisting of 1111, 1135, 1218, 1219, 1322, 1335, and 1337 when compared to SEQ ID NO: 11. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/799440 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/78 (20130101) C12N 15/11 (20130101) C12N 15/86 (20130101) C12N 15/102 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2750/14143 (20130101) C12N 2800/40 (20130101) Enzymes C12Y 305/04002 (20130101) C12Y 305/04005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230116783 | WOO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jung A. WOO (Wesley Chapel, Florida); Stephen Bryant LIGGETT (Treasure Island, Florida); David E. KANG (Wesley Chapel, Florida); Yu CHEN (Tampa, Florida); Eric LEWANDOWSKI (Tampa, Florida) |
| ABSTRACT | As disclosed herein, β-arrestin1 and β-arrestin2 levels are highly elevated in brains of FTLD-tau patients suggesting that both β-arrestin1 and β-arrestin2 are elevated in the brains of patients with AD and FLTD. The current work also shows that when β-arrestin2 is overexpressed, tau levels become elevated. The data indicate that β-arrestin2 reduces tau clearance by impairing p62-mediated autophagy, a role carried out by the oligomerized form of β-arrestin2. Therefore, disclosed herein are β-arrestin oligomerization inhibitors that can be used to prevent β-arrestin oligomerization and therefore the accumulation of tau in cells, i.e. tauopathy. Also disclosed are methods of treating a tauopathy in a subject that involve administering to the subject a therapeutically effective amount of a β-arrestin oligomerization inhibitor disclosed herein. |
| FILED | Monday, February 08, 2021 |
| APPL NO | 17/798041 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/42 (20130101) A61K 31/437 (20130101) A61K 31/496 (20130101) A61K 38/1709 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230116814 | Skala et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Melissa Caroline Skala (Middleton, Wisconsin); Alexandra Jule Walsh (Madison, Wisconsin) |
| ABSTRACT | Systems and methods for sorting T cells are disclosed. Autofluorescence data is acquired from individual cells. An activation value is computed using one or more autofluorescence endpoints as an input. The one or more autofluorescence endpoints includes NAD(P)H shortest fluorescence lifetime amplitude component (α1). |
| FILED | Friday, July 01, 2022 |
| APPL NO | 17/855929 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) Original (OR) Class B01L 2200/143 (20130101) B01L 2200/0652 (20130101) B01L 2300/0663 (20130101) B01L 2300/0864 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0087 (20130101) C12N 5/0636 (20130101) C12N 2510/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6408 (20130101) G01N 21/6428 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230116883 | Riley et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, None) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lee Woodland Riley (Berkeley, California); Nicole Jackson (Berkeley, California) |
| ABSTRACT | The disclosure provides for a polyclonal antibody that specifically detects Acinetobacter baumannii, a multi-drug resistant (MDR) bacterial pathogen, and uses thereof, including as diagnostic tests and for immunoassays to be used in therapeutic decision-making or research experiments. |
| FILED | Tuesday, March 30, 2021 |
| APPL NO | 17/914274 |
| CURRENT CPC | Peptides C07K 16/1217 (20130101) Original (OR) Class C07K 2317/33 (20130101) C07K 2317/92 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56911 (20130101) G01N 2333/22 (20130101) G01N 2469/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230116897 | Hosseinzadeh Taher et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mohammad Reza Hosseinzadeh Taher (Tempe, Arizona); Fatemeh Haghighi (Tempe, Arizona); Ruibin Feng (Scottsdale, Arizona); Jianming Liang (Scottsdale, Arizona) |
| ABSTRACT | Described herein are means for implementing systematic benchmarking analysis to improve transfer learning for medical image analysis. An exemplary system is configured with specialized instructions to cause the system to perform operations including: receiving training data having a plurality medical images therein; iteratively transforming a medical image from the training data into a transformed image by executing instructions for resizing and cropping each respective medical image from the training data to form a plurality of transformed images; applying data augmentation operations to the transformed images; applying segmentation operations to the augmented images; pre-training an AI model on different input images which are not included in the training data by executing self-supervised learning for the AI model; fine-tuning the pre-trained AI model to generate a pre-trained diagnosis and detection AI model; applying the pre-trained diagnosis and detection AI model to a new medical image to render a prediction as to the presence or absence of a disease within the new medical image; and outputting the prediction as a predictive medical diagnosis for a medical patient. |
| FILED | Friday, October 07, 2022 |
| APPL NO | 17/961896 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/0012 (20130101) Image or Video Recognition or Understanding G06V 10/82 (20220101) G06V 10/774 (20220101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20230109968 | SAWYERS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Charles L. SAWYERS (New York, New York); Michael JUNG (Los Angeles, California); Charlie D. CHEN (Shanghai, China PRC); Samedy OUK (San Diego, California); Derek WELSBIE (Lutherville-Timonium, Maryland); Chris TRAN (New York, New York); John WONGVIPAT (New York, New York); Dongwon YOO (Los Angeles, California) |
| ABSTRACT | The present invention relates to diarylhydantoin compounds, including diarylthiohydantoins, and methods for synthesizing them and using them in the treatment of hormone refractory prostate cancer. |
| FILED | Wednesday, July 13, 2022 |
| APPL NO | 17/863841 |
| CURRENT CPC | Heterocyclic Compounds C07D 233/70 (20130101) C07D 233/74 (20130101) C07D 233/86 (20130101) C07D 235/02 (20130101) Original (OR) Class C07D 471/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230110020 | Graham |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Simmonds Precision Products, Inc. (Vergennes, Vermont) |
| ASSIGNEE(S) | Simmonds Precision Products, Inc. (Vergennes, Vermont) |
| INVENTOR(S) | Jason Graham (Prior Lake, Minnesota) |
| ABSTRACT | A heatsink can include a body, one or more thermal fin arrays defined by and/or extending from the body, and a phase change material disposed in contact with the one or more fin arrays. The phase change material can be configured to be a first phase in a cool state and a second phase in a heated state. The phase change material is configured to be cooled back to the solid state. |
| FILED | Friday, October 08, 2021 |
| APPL NO | 17/497671 |
| CURRENT CPC | Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/0203 (20130101) H05K 7/2039 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230110246 | Cao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Han Cao (San Diego, California); Jonas O. Tegenfeldt (Lund, Sweden); Stephen Chou (Princeton, New Jersey); Robert H. Austin (Princeton, New Jersey) |
| ABSTRACT | A fluidic chip includes at least one nanochannel array, the nanochannel array including a surface having a nanofluidic area formed in the material of the surface; a microfluidic area on said surface; a gradient interface area having a gradual elevation of height linking the microfluidic area and the nanofluidic area; and a sample reservoir capable of receiving a fluid in fluid communication with the microfluidic area. In another embodiment, a fluidic chip includes at least one nanochannel array, the nanochannel array includes a surface having a nanofluidic area formed in the material of the surface; a microfluidic area on said surface; and a gradient interface area linking the microfluidic area and the nanofluidic area, where the gradient interface area comprises a plurality of gradient structures, and the lateral spacing distance between said gradient structures decreases towards said nanofluidic area; and a sample reservoir capable of receiving a fluid in fluid communication with the microfluidic area. |
| FILED | Tuesday, November 29, 2022 |
| APPL NO | 18/059476 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502707 (20130101) B01L 3/502715 (20130101) B01L 3/502746 (20130101) B01L 3/502761 (20130101) B01L 2200/12 (20130101) B01L 2200/027 (20130101) B01L 2200/0663 (20130101) B01L 2300/0654 (20130101) B01L 2300/0896 (20130101) B01L 2400/086 (20130101) B01L 2400/0415 (20130101) Microstructural Devices or Systems, e.g Micromechanical Devices B81B 2201/058 (20130101) Processes or Apparatus Specially Adapted for the Manufacture or Treatment of Microstructural Devices or Systems B81C 1/00119 (20130101) B81C 2201/0157 (20130101) B81C 2201/0159 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6486 (20130101) Original (OR) Class G01N 33/48721 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/2008 (20130101) Technical Subjects Covered by Former US Classification Y10T 436/143333 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230110366 | CARROLL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wake Forest University (Winston-Salem, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David L. CARROLL (Winston-Salem, North Carolina); Chaochao DUN (Winston-Salem, North Carolina); Corey HEWITT (Winston-Salem, North Carolina); Robert SUMMERS (Clemmons, North Carolina) |
| ABSTRACT | Composite nanoparticle compositions and associated nanoparticle assemblies exhibit enhancements to one or more thermoelectric properties including increases in electrical conductivity and/or Seebeck coefficient and/or decreases in thermal conductivity. A composite nanoparticle composition comprises a semiconductor nanoparticle including a front face and a back face and sidewalls extending between the front and back faces. Metallic nanoparticles are bonded to at least one of the sidewalls establishing a metal-semiconductor junction. |
| FILED | Friday, July 01, 2022 |
| APPL NO | 17/856854 |
| CURRENT CPC | Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2004/24 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/881 (20130101) Indexing Scheme Associated With Subclass C10M Relating to Lubricating Compositions C10N 2020/06 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 35/18 (20130101) Original (OR) Class H01L 35/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230110450 | Iroh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Cincinnati (Cincinnati, Ohio) |
| ASSIGNEE(S) | University of Cincinnati (Cincinnati, Ohio) |
| INVENTOR(S) | Jude Onwuegbu Iroh (Mason, Ohio); Xuemei Cui (Cincinnati, Ohio); Shengdong Xiao (Crittenden, Kentucky); Ruchinda S. Gooneratne (Cincinnati, Ohio) |
| ABSTRACT | A method of making a three-dimensional object comprising one or more polyimide copolymers, polyimide composites or combinations thereof is provided. The method involves 3D printing a solution comprising polyamic acid (PAA), tetraethyl orthosilicate (TEOS), and a silane selected from the group consisting of aminopropyl trimethoxysilane (APTMS), aminopropyl triethoxysilane (APTES), N-[3-(trimethoxysilyl)propyl]-ethylene diamine (ETDA), and glycidoxypropyl trimethoxysilane (GPTMS) to produce a three-dimensional form, and thermosetting the three-dimensional form. |
| FILED | Tuesday, July 26, 2022 |
| APPL NO | 17/873856 |
| CURRENT CPC | Compositions of Macromolecular Compounds C08L 79/08 (20130101) C08L 2205/025 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 179/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230110695 | Krishnamoorthy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Houston System (Houston, Texas); NSWC Crane (Crane, Indiana) |
| ASSIGNEE(S) | University of Houston System (Houston, Texas); NSWC Crane (Crane, Indiana) |
| INVENTOR(S) | Harish Krishnamoorthy (Missouri City, Texas); Joshua Hawke (Bloomington, Indiana) |
| ABSTRACT | A system for monitoring a circuit, comprising a device under test, such as a power field effect transistor or capacitor, coupled to a power source and a signal source and configured to generate a power output using the signal source, a current output, a voltage output and an end of life detector coupled to the current output and the voltage output and configured to generate a first impedance as a function of the current output and the voltage output, to compare the first impedance to a second impedance and to generate an indicator if the first impedance exceeds the second impedance. |
| FILED | Friday, October 07, 2022 |
| APPL NO | 17/961854 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/64 (20200101) G01R 31/2621 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230111165 | Susca et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan Susca (Windsor, Connecticut); Morgan O'Rorke (West Hartford, Connecticut); Todd Haugsjaahabink (Springfield, Massachusetts) |
| ABSTRACT | A method of controlling an actuator includes switching a primary solenoid valve to a first mode to fluidically connect a supply pressure source to a control chamber of a pilot valve. A fluid from the supply pressure source is directed through the primary solenoid valve to fill the control chamber of the pilot valve and put the pilot valve in a first position. The first position fluidically connects a second chamber of the actuator to a return pressure source. The actuator includes a cylinder between the first chamber and the second chamber and a rod attached to the cylinder. The fluid from the supply pressure source is directed into the first chamber of the actuator to move the cylinder and the rod in a first direction while the pilot valve is in the first position. |
| FILED | Wednesday, October 13, 2021 |
| APPL NO | 17/450800 |
| CURRENT CPC | Systems Acting by Means of Fluids in General; Fluid-pressure Actuators, e.g Servomotors; Details of Fluid-pressure Systems, Not Otherwise Provided for F15B 13/044 (20130101) F15B 13/0402 (20130101) Original (OR) Class F15B 13/0431 (20130101) Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 11/07 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230111177 | NOEL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The MITRE Corporation (McLean, Virginia) |
| ASSIGNEE(S) | The MITRE Corporation (McLean, Virginia) |
| INVENTOR(S) | Steven E. NOEL (Woodbridge, Virginia); Man M. Sapra (Aldie, Virginia); Stephen F. Purdy (Springfield, Virginia); Jeremy T. Martin (Bel Air, Maryland); Mandira D. Hegde (Rosedale, Maryland); Brianna L. Chen (Arlington, Virginia) |
| ABSTRACT | Disclosed herein are system, method, and computer program product embodiments for creating cyber situational understanding in an operational environment. An embodiment operates by normalizing streaming cyber information for a plurality of cyberspace entities and generating cyber-graphs based on relationships between two or more of the plurality of cyberspace entities. A cyber-threat inquiry of the cyber-graphs returns potential cyber-threats that are subsequently visualized as an overlay on a corresponding operational environment. |
| FILED | Thursday, October 07, 2021 |
| APPL NO | 17/496519 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 5/02 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/1425 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230111275 | Hayashi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cody K. Hayashi (Waipahu, Hawaii); Carlos M. Torres, JR. (San Diego, California); Richard C. Ordonez (Mililani, Hawaii); Nackieb M. Kamin (Kapolei, Hawaii); David Garmire (Ann Arbor, Michigan) |
| ABSTRACT | A differential amplifier includes an unmatched pair, including first quantum dots and second quantum dots, and a matched pair, including first and second phototransistors. The unmatched pair has a difference between a first spectrum absorbed by the first quantum dots and a second spectrum absorbed by the second quantum dots. Each of the first and second phototransistors includes a channel. The first quantum dots absorb the first spectrum from incident electromagnetic radiation and gate a first current through the channel of the first phototransistor, and the second quantum dots absorb the second spectrum from the incident electromagnetic radiation and gate a second current through the channel of the second phototransistor. The first and second phototransistors are coupled together for generating a differential output from the first and second currents, the differential output corresponding to the difference between the first and second spectrums within the incident electromagnetic radiation. |
| FILED | Tuesday, October 12, 2021 |
| APPL NO | 17/499747 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/1129 (20130101) H01L 31/035218 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230111416 | Hohne et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Vertex Aerospace, LLC (Madison, Mississippi) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles C. Hohne (Carmel, Indiana); Todd A. Swails (Greenwood, Indiana); Christopher J. Nord (Indianapolis, Indiana); Christopher J. Pulling (Fishers, Indiana); Kristi Irgens (Breckenridge, Colorado); Howard Turner (McCordsville, Indiana); Ian A. Knopf (Indianapolis, Indiana); Vincent A. Maglio (Fishers, Indiana); Kyle A. Brown (Fishers, Indiana) |
| ABSTRACT | An apparatus is provided, comprising: a volatile memory; a non-volatile memory; a first electronic circuit that is configured to operate as a wireless access point, the first electronic circuit including a wireless controller for accessing a wireless network; and a second electronic circuit that is operatively coupled to the first electronic circuit, the second electronic circuit including at least one processor configured to execute: (i) a first virtual machine that includes a wireless network authentication server, and (ii) a second virtual machine that includes a virtual private network (VPN) server, wherein the wireless network authentication server is configured to authenticate devices that attempt to join the wireless network; wherein the VPN server is arranged to encrypt data that is received at the apparatus to produce encrypted data, and forward the encrypted data to the wireless controller for transmission over the wireless network. |
| FILED | Monday, December 12, 2022 |
| APPL NO | 18/064332 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/45558 (20130101) G06F 2009/45583 (20130101) G06F 2009/45595 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/0272 (20130101) Original (OR) Class Wireless Communication Networks H04W 12/06 (20130101) H04W 12/037 (20210101) H04W 12/088 (20210101) H04W 12/121 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230112505 | YADAV et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of South Florida (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hariom YADAV (Land O'Lakes, Florida); Shalini JAIN (Land O'Lakes, Florida); Sidharth MISHRA (Tampa, Florida) |
| ABSTRACT | Described are methods of treating neurodegenerative disease by administering a therapeutically effective amount of fenchol to a patient in need thereof. Additionally, described are methods of activating FFAR2 signaling in a patient by administering a therapeutically effective amount of fenchol to a patient in need thereof. Methods of treating gastrointestinal disorders in a patient being treated for cancer and methods of improving cognition in a patient being treated for cancer are also described. Further, the present disclosure provides for a pharmaceutical composition including fenchol and an Alzheimer's disease drug. Additionally, a nasal spray including fenchol, a buccal tablet including fenchol, and a dietary supplement including fenchol are described. |
| FILED | Friday, July 01, 2022 |
| APPL NO | 17/856400 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/006 (20130101) A61K 31/045 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230112711 | Iroh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Cincinnati (Cincinnati, Ohio) |
| ASSIGNEE(S) | University of Cincinnati (Cincinnati, Ohio) |
| INVENTOR(S) | Jude Onwuegbu Iroh (Mason, Ohio); Shengdong Xiao (Crittenden, Kentucky); Ruchinda Seth Gooneratne (Cincinnati, Ohio); Xuemei Cui (Cincinnati, Ohio) |
| ABSTRACT | A method of curing polyimide, polyimide copolymers, polyimide composites or combinations is provided. The method involves preparing a reaction system comprising poly(amic acid) and at least one other compound selected from the group consisting of copolymers, solvents, fillers and nanofillers. Then, a combined overall microwave absorptivity of the reaction system is determined. A temperature ramp rate is calculated for a microwave power level and time using the combined overall microwave absorptivity. The reaction system is then exposed to microwave radiation according to the calculated temperature ramp rate, producing a cured product. |
| FILED | Thursday, September 15, 2022 |
| APPL NO | 17/945420 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 73/1025 (20130101) Original (OR) Class Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/041 (20170501) C08K 2201/005 (20130101) C08K 2201/011 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230113503 | Tour et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | William Marsh Rice University (Houston, Texas) |
| ASSIGNEE(S) | WILLIAM MARSH RICE UNIVERSITY (Houston, Texas) |
| INVENTOR(S) | James M. Tour (Houston, Texas); Rodrigo Villegas Salvatierra (Houston, Texas); Gladys Anahi Lopez Silva (Houston, Texas); Abdul-Ramahn O. Raji (Houston, Texas) |
| ABSTRACT | Alkali metal-sulfur cells and batteries with cathode layers that store alkali metal charge carriers (e.g., lithium ions) in agglomerates of sulfurized carbon. The cathode layers lack costly and environmentally unfriendly nickel and cobalt. The cathode layers are composites that include agglomerates of sulfurized-carbon particles in a conductive binder and interconnected by sp2-bonded carbon materials, such as carbon nanotubes or nanoribbons, that extend within the agglomerates and between the sulfurized-carbon particles. |
| FILED | Friday, October 07, 2022 |
| APPL NO | 17/961705 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 35/00 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/38 (20130101) H01M 4/583 (20130101) Original (OR) Class H01M 4/623 (20130101) H01M 4/667 (20130101) H01M 10/0525 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230113535 | Zhou |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | U.S. Army DEVCOM, Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Weimin Zhou (Rockville, Maryland) |
| ABSTRACT | A method, apparatus and system for performing optical positioning. The apparatus comprises a laser transmitter configured to transmit a laser beam toward a retroreflector, where the location of retroreflector is known and the retroreflector reflects the laser beam and imparts modulation onto the laser beam. An optical receiver receives the reflected laser beam reflected from the retroreflector and a processor extracts a code from the modulation, determines the location of the retroreflector and calculates the distance from the apparatus to the retroreflector and uses the code and distance to determine a position of the apparatus. |
| FILED | Wednesday, October 13, 2021 |
| APPL NO | 17/500092 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/3844 (20200801) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/484 (20130101) G01S 7/4808 (20130101) Original (OR) Class G01S 7/4817 (20130101) G01S 7/4861 (20130101) G01S 17/10 (20130101) G01S 17/86 (20200101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/0085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230114053 | Gattass et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rafael R. Gattass (Washington, District of Columbia); L. Brandon Shaw (Woodbridge, Virginia); Daniel L. Rhonehouse (Huntingtown, Maryland); Jasbinder S. Sanghera (Ashburn, Virginia) |
| ABSTRACT | An apparatus includes a first photonic crystal fiber. The first photonic crystal fiber includes a first dispersion at a pump wavelength. The first photonic crystal fiber includes a zero dispersion. The pump wavelength is within 100 nm of the zero dispersion. The first dispersion is normal. The first photonic crystal fiber includes a first mode field diameter at the pump wavelength. The apparatus also includes a second photonic crystal fiber coupled to the first photonic crystal fiber and outputs a broadband spectrum. The second photonic crystal fiber includes a second dispersion at the pump wavelength. The second dispersion is anomalous. The second dispersion is negative, and the first dispersion is positive. The second photonic crystal fiber includes a second mode field diameter at the pump wavelength. The second mode field diameter is smaller than the first mode field diameter. |
| FILED | Tuesday, December 13, 2022 |
| APPL NO | 18/080063 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/395 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/1083 (20130101) H01S 3/06716 (20130101) H01S 3/06741 (20130101) Original (OR) Class H01S 3/094007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230114057 | Rush et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GE AVIATION SYSTEMS LLC (GRAND RAPIDS, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian Magann Rush (Niskayuna, New York); Christopher James Kapusta (Delanson, New York); David Richard Esler (Gloversville, New York); Liang Yin (Clifton Park, New York); Richard Anthony Eddins (Margate, Florida); Judd Everett Swanson (Margate, Florida); Liqiang Yang (Coral Springs, Florida) |
| ABSTRACT | The disclosure relates to an apparatus and method for liquid cooling of an electronic component. A housing includes an insertion slot and defines at least one component chamber for carrying the electronic component. A fluid inlet and fluid outlet are provided on the housing. A liquid coolant circuit passes through the housing at least from the inlet to the outlet. |
| FILED | Tuesday, October 12, 2021 |
| APPL NO | 17/499324 |
| CURRENT CPC | Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 7/20254 (20130101) Original (OR) Class H05K 7/20272 (20130101) H05K 7/20281 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230114124 | Goodman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Goodman Technologies LLC (Albuquerque, New Mexico); University of Hawai'i (Honolulu, Hawaii) |
| ASSIGNEE(S) | Goodman Technologies LLC (Albuquerque, New Mexico); University of Hawai'i (Honolulu, Hawaii) |
| INVENTOR(S) | William A. Goodman (Albuquerque, New Mexico); Mohammad Naghi Ghasemi-Nejhad (Honolulu, Hawaii); Pouria Taeb (Kapolei, Hawaii); Brenden Masao Minei (Honolulu, Hawaii) |
| ABSTRACT | A reinforcement for increasing the strength and toughness and other properties in both transverse and in-piano directions for a composite material, and methods of manufacture therefor. The reinforcement has a layer of a nanoforest of vertical nanotubes or nanowires and a layer of horizontal nanotubes or nanowires. The reinforcement can be made by rolling a vertical nanoforest to produce a collapsed layer of horizontal nanofubes or nanowires, then growing a vertical nanoforest on the collapsed layer. The reinforcement can be grown directly on fibers which are used to reinforce the composite material, or alternatively Interleaved with layers of those fibers before the composite part is cured. The reinforcement and manufacturing method are compatible with almost any composite material in any shape, including epoxy, polymer, or ceramic matrix composites, or any manufacturing method, including prepreg, wet-layup and matrix film stacking. The present invention reduces scrap, rework, and repair hours for composites manufacturing. |
| FILED | Thursday, January 28, 2021 |
| APPL NO | 17/795969 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 1/00 (20130101) B32B 5/12 (20130101) Original (OR) Class B32B 5/26 (20130101) B32B 7/02 (20130101) B32B 2250/40 (20130101) B32B 2260/021 (20130101) B32B 2260/046 (20130101) B32B 2262/10 (20130101) B32B 2262/106 (20130101) B32B 2307/732 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/16 (20170801) C01B 32/168 (20170801) C01B 2202/08 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2004/03 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/243 (20210501) C08J 5/249 (20210501) C08J 2363/00 (20130101) C08J 2379/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230114370 | Akhalwaya et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ismail Yunus Akhalwaya (Emmarentia, South Africa); Kenneth Clarkson (Madison, New Jersey); Lior Horesh (North Salem, New York); Mark S. Squillante (Greenwich, Connecticut); Shashanka Ubaru (Ossining, New York); Vasileios Kalantzis (White Plains, New York) |
| ABSTRACT | Techniques and a system to facilitate estimation of a quantum phase, and more specifically, to facilitate estimation of an expectation value of a quantum state, by utilizing a hybrid of quantum and classical methods are provided. In one example, a system is provided. The system can comprise a memory that stores computer executable components and a processor that executes the computer executable components stored in the memory. The computer executable components can include an encoding component and a learning component. The encoding component can encode an expectation value associated with a quantum state. The learning component can utilize stochastic inference to determine the expectation value based on an uncollapsed eigenvalue pair. |
| FILED | Friday, January 31, 2020 |
| APPL NO | 16/778878 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 5/04 (20130101) G06N 10/20 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230114728 | BURNS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Venatorx Pharmaceuticals, Inc. (Malvem, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher J. BURNS (Malvern, Pennsylvania); Denis DAIGLE (Street, Maryland); Guo-Hua CHU (Exton, Pennsylvania); Jodie HAMRICK (New Holland, Pennsylvania); Steven A. BOYD (Chester Springs, Pennsylvania); Allison L. ZULLI (Chesterbrook, Pennsylvania); Stephen M. CONDON (Glenmoore, Pennsylvania); Cullen L. MYERS (Phoenixville, Pennsylvania); Zhenrong XU (Chalfont, Pennsylvania); Tsuyoshi Uehara (Berwyn, Pennsylvania); Nathan LINE (Royersford, Pennsylvania) |
| ABSTRACT | Described herein are certain boron-containing compounds, compositions, preparations and their use as modulators of the transpeptidase function of bacterial penicillin-binding proteins and as antibacterial agents. In some embodiments, the compounds described herein inhibit penicillin-binding proteins. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections. |
| FILED | Thursday, September 24, 2020 |
| APPL NO | 17/779804 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/20 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230115278 | TURNER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Assured Information Security, Inc. (Rome, New York) |
| ASSIGNEE(S) | Assured Information Security, Inc. (Rome, New York) |
| INVENTOR(S) | Richard TURNER (Verona, New York); Joel UPHAM (Paris, New York) |
| ABSTRACT | Provision of a virtual secure cryptoprocessor (VSC) for a guest virtual machine (VM), part of a first guest, of a hypervisor of a computer system, includes (i) storing guest VM state and VSC state together in an encrypted virtual hard disk drive file, (ii) storing a decryption key in a sealed partition, of a second guest, sealed against a physical secure cryptoprocessor, (iii) based on verifying that a host computing environment of the computer system is in a trusted state and on booting the hypervisor thereon, unsealing the sealed partition of the second guest, the unsealing providing the decryption key, and decrypting the encrypted virtual hard disk drive file using the decryption key, where the decrypting decrypts the stored guest VM state for execution of the guest VM and decrypts the VSC state to provide the VSC for use by the guest VM. |
| FILED | Tuesday, March 31, 2020 |
| APPL NO | 16/835875 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/45558 (20130101) Original (OR) Class G06F 2009/45583 (20130101) G06F 2009/45587 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0897 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230115308 | Lundin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Jeffrey G. Lundin (Burke, Virginia); Matthew D. Thum (Annapolis, Maryland); Jakub Kolacz (Alexandria, Virginia); Daniel Ratchford (Alexandria, Virginia) |
| ABSTRACT | Disclosed herein is a fiber having a sheath including a polymer and a core including a non-cholesteric liquid crystal. The sheath is transparent to visible light. The fiber may an average diameter of no more than 10 microns, and at least 90% of the fiber has a diameter within 20% of the average diameter. The sheath may include a compound capable of photoisomerization that extends into the core. The interference color of the fiber may be reversibly changed by exposure to light or a temperature change. |
| FILED | Friday, October 07, 2022 |
| APPL NO | 18/045142 |
| CURRENT CPC | Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/23 (20130101) C08K 5/315 (20130101) C08K 9/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230116132 | Grudic et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Flashback Technologies, Inc. (Vienna, Virginia); The Regents Of The University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregory Zlatco Grudic (Niwot, Colorado); Steven L Moulton (Littleton, Colorado); Isobel Jane Mulligan (Niwot, Colorado) |
| ABSTRACT | Tools and techniques for estimating a probability that a patient is bleeding or has sustained intravascular volume loss (e.g., due to hemodialysis or dehydration) and/or to estimate a patient’s current hemodynamic reserve index, track the patient’s hemodynamic reserve index over time, and/or predict a patient’s hemodynamic reserve index in the future. Tools and techniques for estimating and/or predicting a patient’s dehydration state. Tools and techniques for controlling a hemodialysis machine based on the patient’s estimated and/or predicted hemodynamic reserve index. |
| FILED | Friday, July 01, 2022 |
| APPL NO | 17/856555 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/021 (20130101) A61B 5/029 (20130101) A61B 5/318 (20210101) A61B 5/02028 (20130101) Original (OR) Class A61B 5/02042 (20130101) A61B 5/7275 (20130101) A61B 5/14551 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 40/60 (20180101) G16H 50/30 (20180101) Technologies for Adaptation to Climate Change Y02A 90/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230116394 | DITOMASSO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | RAYTHEON TECHNOLOGIES CORPORATION (Farmington, Connecticut) |
| ASSIGNEE(S) | RAYTHEON TECHNOLOGIES CORPORATION (Farmington, Connecticut) |
| INVENTOR(S) | JOHN C. DITOMASSO (Glastonbury, Connecticut); MATTHEW P. FORCIER (South Windsor, Connecticut) |
| ABSTRACT | A tandem rotor disk apparatus may include a rotor disk body concentric about an axis. The tandem rotor disk apparatus may also include a first blade extending radially outward of the rotor disk body and a second blade extending radially outward of the rotor disk body. The first blade may be offset from the second blade in a direction parallel to the axis. The tandem rotor disk apparatus may be implemented in a gas turbine engine with no intervening stator vane stages disposed between the first blade and the second blade. |
| FILED | Wednesday, December 07, 2022 |
| APPL NO | 18/077084 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/34 (20130101) F01D 5/142 (20130101) F01D 5/146 (20130101) F01D 5/3007 (20130101) F01D 5/3038 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 3/04 (20130101) Non-positive-displacement Pumps F04D 19/02 (20130101) F04D 29/321 (20130101) F04D 29/322 (20130101) F04D 29/324 (20130101) Original (OR) Class F04D 29/644 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20230109863 | HAYES et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE PENN STATE RESEARCH FOUNDATION (UNIVERSITY PARK, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel J. HAYES (State College, Pennsylvania); Mohammad ABU-LABAN (State College, Pennsylvania) |
| ABSTRACT | In one aspect, compositions are described herein. A composition described herein comprises a nanoparticle, a therapeutic species, and a linker joining the nanoparticle to the therapeutic species. The linker joining the nanoparticle to the therapeutic species comprises a Diels-Alder cyclo-addition reaction product. Additionally, in some embodiments, the nanoparticle is a magnetic nanoparticle. |
| FILED | Wednesday, December 07, 2022 |
| APPL NO | 18/076772 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5094 (20130101) Original (OR) Class A61K 9/5115 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230110437 | Green et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | nView medical Inc. (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jared Green (Salt Lake City, Utah); Mark Elliott (Salt Lake City, Utah); Cristian Atria (Salt Lake City, Utah) |
| ABSTRACT | The present technology relates to an imaging system. The imaging system can comprise at least one processor configured to apply a projection precomputation algorithm and an x-ray tomography image reconstruction system. The projection precomputation algorithm can be configured to: generate a projection operator matrix that can be used to calculate a plurality of voxels from a plurality of projection measurements before the plurality of projection measurements is acquired and store the projection operator matrix in memory. The projection operator matrix can be at least one of: a compressed matrix, a multi-iteration projection operator matrix, and a combination thereof. The x-ray tomography image reconstruction system can be configured to apply the projection operator matrix to generate a reconstructed three-dimensional image of at least an internal portion of a selected object under a surface of the selected object when the plurality of projection measurements is acquired. |
| FILED | Tuesday, October 11, 2022 |
| APPL NO | 17/963927 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 11/006 (20130101) G06T 11/008 (20130101) Original (OR) Class G06T 2210/41 (20130101) G06T 2211/412 (20130101) G06T 2211/424 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230110619 | Khanicheh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | EnVision Endoscopy, Inc. (Somerville, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Azadeh Khanicheh (Somerville, Massachusetts); Amos G. Cruz (Wrentham, Massachusetts); Judy Walish (Boston, Massachusetts) |
| ABSTRACT | A method cinches a suture. The method provides a cinch having a suture capturing portion configured to capture a suture, a cinch lock coupled with the suture capturing portion, and a cinch anchor having a lumen. The suture capturing portion is extended out of the lumen to capture the suture. The suture is captured by the suture capturing portion. The suture capturing portion is retracted into the lumen of the cinch anchor. The suture is cinched between the cinch lock and the cinch anchor. |
| FILED | Monday, November 21, 2022 |
| APPL NO | 17/991526 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/0401 (20130101) A61B 17/0469 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230110778 | Balapour et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Drexel University (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | Drexel University (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Mohammad Balapour (Philadelphia, Pennsylvania); Yaghoob Farnam (Philadelphia, Pennsylvania) |
| ABSTRACT | Manufacturing lightweight aggregate (LWA) by a sintering technique requires a delicate balance among three conditions: forming sufficient amount of molten liquid phase during sintering; reaching an appropriate viscosity for solid-liquid suspension; and emitting sufficient amount of gas that can be entrapped by the liquid phase to form pores. LWAs were made from low-calcium and high-calcium Waste Coal Combustion Ash (W-CCA) including fly ash and bottom ash. A mass fraction of at least 40% liquid phase for fly ash and 50% for bottom ash is required for a successful entrapment of emitted gaseous phases during sintering. Larger pores were observed in the microstructure of LWA samples made using high-calcium W-CCA in comparison to low-calcium W-CCA. This result was mainly attributed to the high-calcium samples forming liquid phases with lower viscosity values and emitting higher amounts of gaseous phase during sintering than did the low-calcium samples. The gaseous phase was generated by hematite reduction and anhydrite decomposition. |
| FILED | Tuesday, April 26, 2022 |
| APPL NO | 17/729039 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 18/084 (20130101) Original (OR) Class C04B 2111/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230111712 | Jewett et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John C. Jewett (Tucson, Arizona); Garrett Davis (Tucson, Arizona); Holly Sofka (Tucson, Arizona) |
| ABSTRACT | Modular Meldrum's acid amine-reactive Michael acceptor (MaMa)—based molecules that are stable probes for high pH environents and bioconjugations. The molecules of the present invention can selectively label and protect lysine residues. In certain embodiments, the molecules can selectively react with lysine at particular pH levels. The probes of the present invention may be used to label proteins in a fluorescent manner, for purification, imaging, or general protein modifications, however the present invention is not limited to the aforementioned applications. |
| FILED | Monday, March 15, 2021 |
| APPL NO | 17/905787 |
| CURRENT CPC | Heterocyclic Compounds C07D 319/06 (20130101) Peptides C07K 1/13 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/533 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230112054 | Kang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TEXAS STATE UNIVERSITY (San Marcos, Texas) |
| ASSIGNEE(S) | TEXAS STATE UNIVERSITY (San Marcos, Texas) |
| INVENTOR(S) | Hong-Gu Kang (Buda, Texas); Sung-II Kim (Bryan, Texas) |
| ABSTRACT | Embodiments of the present disclosure pertain to methods of modulating a stress response in a eukaryotic organism against an environmental stress by introducing an RNA fragment (RF) or an antisense nucleotide to the eukaryotic organism. Thereafter, the RF or antisense nucleotide modulates the stress response against the environmental stress. Additional embodiments of the present disclosure pertain to the RFs and antisense nucleotides of the present disclosure. The RFs generally include: a sequence recognition site that contains a reverse complement sequence of a nucleotide sequence of the organism; and a stem loop structure with a paired region that includes paired RNA nucleotides, and an unpaired region that includes unpaired RNA nucleotides in the form of a loop. The antisense nucleotides may include a reverse complement sequence of the RFs. |
| FILED | Thursday, October 13, 2022 |
| APPL NO | 17/965436 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) Original (OR) Class C12N 15/113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230112437 | Zhang |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Indiana University (Bloomington, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qingxue Zhang (Carmel, Indiana) |
| ABSTRACT | Method and system for acquiring and handling health data from patients using patient and doctor devices and a central system. The patient device gets real time sensor readings and transmit the readings to the central system. The patient device can visualize the readings. The central system stores the readings; and enables doctor devices to access the readings. The central system determines the patient set associated with the doctor, and allows the doctor to access and visualize the readings of any patients in their patient set. Visualization can include creating time series graphs of the readings. The doctor and patient can communicate through the central system. |
| FILED | Thursday, October 07, 2021 |
| APPL NO | 17/496268 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/6245 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) Original (OR) Class G16H 40/20 (20180101) G16H 40/67 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230112618 | Kenane et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Oregon State University (Corvallis, Oregon) |
| ASSIGNEE(S) | Oregon State University (Corvallis, Oregon) |
| INVENTOR(S) | Nizan Kenane (Corvallis, Oregon); Douglas A. Keszler (Corvallis, Oregon) |
| ABSTRACT | Compositions comprising RqSnOm(OH)x(HCO3)y(CO3)z are disclosed, where R is (i) C1—C10 hydrocarbyl or (ii) heteroaliphatic, heteroaryl, or heteroaryl-aliphatic including 1-10 carbon atoms and one or more heteroatoms; q = 0.1-1; x ≤ 4; y ≤ 4; z ≤ 2; m = 2 - q/2 - x/2 - y/2 - z; and (q/2 + x/2 + y/2 + z) ≤ 2 Methods of making a photoresist film comprising [(RSn)12O14(OH)6](OH)2 on a substrate also are disclosed. The photoresist film may be irradiated to form RqSnOm(OH)x(HCO3)y(CO3)z. |
| FILED | Thursday, February 25, 2021 |
| APPL NO | 17/802083 |
| CURRENT CPC | Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/0042 (20130101) Original (OR) Class G03F 7/168 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230112852 | Sarlioglu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bulent Sarlioglu (Madison, Wisconsin); Gregory F. Nellis (Waunakee, Wisconsin); Leyue Zhang (Madison, Wisconsin); Hao Ding (Carson, California) |
| ABSTRACT | An electrical machine includes a rotor, a stator, and a winding mounted within a housing. The rotor includes a rotor core mounted to a shaft and a plurality of blades extending radially away from the rotor core. Each blade of the plurality of blades is curved axially along the rotor core. The stator includes a stator core and a plurality of teeth extending from the stator core toward the rotor core to define a plurality of slots between successive teeth. The winding is wound through at least two slots of the plurality of slots. The stator is mounted radially relative to the rotor. The housing includes a front wall, a back wall, and a radial sidewall mounted between the front wall and the back wall to define an enclosure. A radial inlet aperture wall is formed circumferentially through the radial sidewall to form an opening through the radial sidewall. |
| FILED | Tuesday, October 04, 2022 |
| APPL NO | 17/937798 |
| CURRENT CPC | Dynamo-electric Machines H02K 1/20 (20130101) H02K 1/32 (20130101) H02K 5/20 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230113164 | Epps, III et al. |
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| FUNDED BY |
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| APPLICANT(S) | Thomas H. Epps, III (Bear, Delaware); Angela L. Holmberg (Somerville, Massachusetts); Kaleigh H. Nicastro (Newark, Delaware); Shu Wang (Newark, Delaware); Basudeb Saha (Newark, Delaware); Li Shuai (Blacksburg, Virginia); Dionisios G. Vlachos (Newark, Delaware); Melody A. Morris (Elkton, Maryland) |
| ASSIGNEE(S) | University of Delaware (Newark, Delaware) |
| INVENTOR(S) | Thomas H. Epps, III (Bear, Delaware); Angela L. Holmberg (Somerville, Massachusetts); Kaleigh H. Nicastro (Newark, Delaware); Shu Wang (Newark, Delaware); Basudeb Saha (Newark, Delaware); Li Shuai (Blacksburg, Virginia); Dionisios G. Vlachos (Newark, Delaware); Melody A. Morris (Elkton, Maryland) |
| ABSTRACT | Disclosed herein is a bio-based copolymer comprising in polymerized form (i) at least one polymerizable bio-based monomer containing one phenolic hydroxyl group which has been derivatized to provide at least one polymerizable functional group which is an ethylenically unsaturated functional group (such as a [meth]acrylate group), where the precursors of the polymerizable bio-based monomers are derived from raw lignin-containing biomass, and (ii) at least one ion-conducting co-monomer other than the bio-based monomer. Also disclosed herein are binders comprising the bio-based copolymer, electrodes comprising the binder, polymer electrolytes comprising the bio-based copolymer and an electrochemical device comprising an electrode in electrical contact with a polymer electrolyte, wherein at least one of the electrode and the polymer electrolyte comprises the bio-based copolymer. |
| FILED | Friday, November 04, 2022 |
| APPL NO | 17/980792 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 27/302 (20130101) B32B 27/308 (20130101) Acyclic or Carbocyclic Compounds C07C 41/18 (20130101) C07C 41/38 (20130101) C07C 67/14 (20130101) C07C 69/618 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 293/005 (20130101) Original (OR) Class C08F 2438/01 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 83/005 (20130101) C08G 2170/40 (20130101) Derivatives of Natural Macromolecular Compounds C08H 8/00 (20130101) Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 7/38 (20180101) C09J 7/385 (20180101) C09J 7/387 (20180101) C09J 9/02 (20130101) C09J 125/18 (20130101) C09J 133/08 (20130101) C09J 153/00 (20130101) C09J 2203/33 (20130101) C09J 2301/414 (20200801) C09J 2400/163 (20130101) C09J 2400/226 (20130101) C09J 2400/283 (20130101) C09J 2433/00 (20130101) C09J 2453/00 (20130101) C09J 2471/00 (20130101) C09J 2497/00 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/622 (20130101) H01M 10/0565 (20130101) H01M 2300/0082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230113477 | Genin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri); Columbia University (New York, New York) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri); Columbia University (New York, New York) |
| INVENTOR(S) | Guy Genin (St. Louis, Missouri); Ethan Hoppe (St. Louis, Missouri); Dong Hwan Yoon (St. Louis, Missouri); Stavros Thomopoulos (New York, New York); Iden Kurtaliaj (New York, New York); Liana Tedesco (New York, New York); David Kovacevic (New York, New York); Victor Birman (St. Louis, Missouri); Lester Smith (Indianapolis, Indiana); Leesa Galatz (St. Louis, Missouri); William Levine (New York, New York) |
| ABSTRACT | Devices and methods for joining a first and second tissue in a patient are disclosed that include a base with opposed first and second surfaces, and a plurality of recurved tines oriented to a tine axis and extending from the first surface of the base. The base defines four suture holes extending through the first and second surfaces of the base and configured to receive at least one suture passing between the first and second surfaces of the base. The plurality of recurved tines provides unidirectional traction of the first tissue along the tine axis toward the first surface to secure the device to the first tissue. The device is secured to the second tissue at the second surface with the at least one suture secured to at least one anchor secured to the second tissue. |
| FILED | Wednesday, September 14, 2022 |
| APPL NO | 17/932232 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/0401 (20130101) Original (OR) Class A61B 2017/0412 (20130101) A61B 2017/0414 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230113944 | John et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Varghese John (Los Angeles, California); Tina Bilousova (Santa Monica, California); Bryan Simmons (Santa Clarita, California); Neil Garg (Los Angeles, California); Jesus Campagna (Playa Del Rey, California); Barbara Jagodzinska (Redwood City, California) |
| ABSTRACT | Provided herein are compounds of Formula I and their salts, and compositions thereof that are useful for useful for modulating neutral sphingomyelinase 2 (n-SMase2) and/or acetylcholinesterase (AChE) in cells. Also disclosed herein are methods of using the disclosed compounds and compositions for inhibiting the spread of Tau seeds from donor cells to recipient cells. Further disclosed herein are methods of using the disclosed compounds and compositions for treating or preventing a neurodegenerative disorder, such as a tauopathy, Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), Lewy body dementia, frontotemporal dementia, and amyotrophic lateral sclerosis (ALS). |
| FILED | Friday, January 08, 2021 |
| APPL NO | 17/790407 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) A61P 27/06 (20180101) Heterocyclic Compounds C07D 491/048 (20130101) C07D 491/147 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230114064 | Waldmann et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasanda, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Martin Waldmann (Santa Monica, California); Anton A. Toutov (Magnolia, Texas); Jennifer Marie Murphy (Los Angeles, California); Robert H. Grubbs (South Pasadena, California) |
| ABSTRACT | The present disclosure sets forth novel compounds and compositions including heteroaromatic silicon-fluoride-acceptors, which are useful for PET scanning. The present disclosure further includes novel methods of 8F imaging for PET scanning, the methods comprising the preparation of conjugates and bioconjugates of biological ligands of interest with heteroaromatic silicon-fluoride-acceptors. In certain embodiments the invention is practiced in the form of a kit. |
| FILED | Monday, September 19, 2022 |
| APPL NO | 17/933234 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/1027 (20130101) A61K 51/1072 (20130101) General Methods of Organic Chemistry; Apparatus Therefor C07B 59/004 (20130101) C07B 2200/05 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230114495 | MOON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hyejin MOON (Arlington, Texas); Ali FARZBOD (Arlington, Texas) |
| ABSTRACT | An electrowetting-on-dielectric (EWOD) microfluidic device comprises at least one integrated electrochemical sensor, the electrochemical sensor comprising: a reference electrode; a sensing electrode; and an analyte-selective layer positioned over the sensing electrode. In some embodiments, the electrochemical sensor measures a concentration of an analyte in a fluid sample exposed to the electrochemical sensor based on a potential difference between the reference electrode and the sensing electrode. The first analyte and the second analyte can be selected from a group consisting of K+, Na+, Ca2+, Cl-, HCO3-, Mg2+, H+, Ba2+, Pb2+, Cu2+, I-, NH4+, (SO4)2-. |
| FILED | Monday, November 21, 2022 |
| APPL NO | 17/991401 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502707 (20130101) B01L 3/502715 (20130101) Original (OR) Class B01L 3/502784 (20130101) B01L 2200/12 (20130101) B01L 2300/12 (20130101) B01L 2300/161 (20130101) B01L 2300/165 (20130101) B01L 2300/0645 (20130101) B01L 2300/0681 (20130101) B01L 2300/0887 (20130101) B01L 2400/0427 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/301 (20130101) G01N 27/333 (20130101) G01N 27/4035 (20130101) G01N 27/4161 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230114871 | MI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Baoxia MI (Moraga, California); Meng HU (Baltimore, Maryland) |
| ABSTRACT | A method for synthesizing a water purification membrane is presented. The method includes stacking a plurality of graphene oxide (GO) nanosheets to create the water purification membrane, the stacking involving layer-by-layer assembly of the plurality of GO nanosheets and forming a plurality of nanochannels between the plurality of GO nanosheets for allowing the flow of a fluid and for rejecting the flow of contaminants. The method further includes cross-linking the plurality of GO nanosheets by 1,3,5-benzenetricarbonyl trichloride on a polydopamine coated polysulfone support. |
| FILED | Wednesday, September 14, 2022 |
| APPL NO | 17/944591 |
| CURRENT CPC | Separation B01D 69/10 (20130101) B01D 69/12 (20130101) B01D 71/021 (20130101) B01D 2323/30 (20130101) Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 37/14 (20130101) Original (OR) Class B32B 2038/0076 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/23 (20170801) C01B 32/198 (20170801) Technical Subjects Covered by Former US Classification Y10T 156/10 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230114970 | Quigley et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Loci Controls, Inc. (Wareham, Massachusetts) |
| ASSIGNEE(S) | Loci Controls, Inc. (Wareham, Massachusetts) |
| INVENTOR(S) | Peter Quigley (Duxbury, Massachusetts); Ian Martin (Sharon, Massachusetts); Nicole Neff (North Potomac, Maryland); Jack Rowbottom (Swansea, Massachusetts) |
| ABSTRACT | A control system for controlling extraction of landfill gas from a landfill via a gas extraction system, the gas extraction system comprising well piping for coupling a plurality of wells to a gas output. The control system comprises a controller configured to: obtain a value indicating measured energy content of landfill gas collected at the gas output from the plurality of wells; determine whether the measured energy content is different from a target energy content; and in response to determining that the measured energy content is different from the target energy content: control a plurality of valves disposed in the well piping to change flow rates of landfill gas being extracted from at least some of the plurality of wells at least in part by changing degrees to which the plurality of valves are open. |
| FILED | Tuesday, October 04, 2022 |
| APPL NO | 17/959446 |
| CURRENT CPC | Disposal of Solid Waste B09B 1/006 (20130101) Original (OR) Class Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 34/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230115158 | Didehban et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Moslem Didehban (Tempe, Arizona); Aviral Shrivastava (Phoenix, Arizona); Sai Ram Dheeraj Lokam (Chandler, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| INVENTOR(S) | Moslem Didehban (Tempe, Arizona); Aviral Shrivastava (Phoenix, Arizona); Sai Ram Dheeraj Lokam (Chandler, Arizona) |
| ABSTRACT | A method for detecting and recovery from a soft error in a computing device is provided. In examples discussed herein, the method can be performed to detect soft errors that may occur during execution of a predefined critical instruction(s) and/or has been propagated in the computing device prior to the execution of the predefined critical instruction(s). Specifically, a software compiler may be used to embed an error detector block(s) after the predefined critical instruction(s). In this regard, the error detector block(s) can be executed after the predefined critical instruction(s) to detect the soft error. Accordingly, it may be possible to invoke a diagnosis routine to determine severity of the detected soft error and take appropriate action against the detected soft error. As such, it may be possible to protect the execution of the predefined critical instruction(s) concurrent to eliminating vulnerable voting intervals and reducing soft error detection overhead. |
| FILED | Monday, September 19, 2022 |
| APPL NO | 17/947825 |
| CURRENT CPC | Electric Digital Data Processing G06F 11/079 (20130101) Original (OR) Class G06F 11/0706 (20130101) G06F 11/0793 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230116103 | Trovitch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ryan J. Trovitch (Phoenix, Arizona); Anuja Sharma (Mumbai, India); Thu Thao Nguyen (Mesa, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan J. Trovitch (Phoenix, Arizona); Anuja Sharma (Mumbai, India); Thu Thao Nguyen (Mesa, Arizona) |
| ABSTRACT | Aryl diimine first row metal compounds are described, as well as their synthesis and use as catalysts for the hydrofunctionalization of unsaturated organic compounds and main group element—main group element bond formation by dehydrogenative coupling. |
| FILED | Tuesday, September 27, 2022 |
| APPL NO | 17/953546 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 13/00 (20130101) Original (OR) Class C07F 15/02 (20130101) C07F 15/04 (20130101) C07F 15/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230116132 | Grudic et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Flashback Technologies, Inc. (Vienna, Virginia); The Regents Of The University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregory Zlatco Grudic (Niwot, Colorado); Steven L Moulton (Littleton, Colorado); Isobel Jane Mulligan (Niwot, Colorado) |
| ABSTRACT | Tools and techniques for estimating a probability that a patient is bleeding or has sustained intravascular volume loss (e.g., due to hemodialysis or dehydration) and/or to estimate a patient’s current hemodynamic reserve index, track the patient’s hemodynamic reserve index over time, and/or predict a patient’s hemodynamic reserve index in the future. Tools and techniques for estimating and/or predicting a patient’s dehydration state. Tools and techniques for controlling a hemodialysis machine based on the patient’s estimated and/or predicted hemodynamic reserve index. |
| FILED | Friday, July 01, 2022 |
| APPL NO | 17/856555 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/021 (20130101) A61B 5/029 (20130101) A61B 5/318 (20210101) A61B 5/02028 (20130101) Original (OR) Class A61B 5/02042 (20130101) A61B 5/7275 (20130101) A61B 5/14551 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 40/60 (20180101) G16H 50/30 (20180101) Technologies for Adaptation to Climate Change Y02A 90/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230116167 | Khanicheh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | EnVision Endoscopy, Inc. (Somerville, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Azadeh Khanicheh (Somerville, Massachusetts); Amos G. Cruz (Wrentham, Massachusetts) |
| ABSTRACT | A method cinches a suture. The method provides a cinch having a suture capturing portion configured to capture a suture, a cinch lock coupled with the suture capturing portion, and a cinch anchor having a lumen. The suture capturing portion is extended out of the lumen to capture the suture. The suture is captured by the suture capturing portion. The suture capturing portion is retracted into the lumen of the cinch anchor. The suture is cinched between the cinch lock and the cinch anchor. |
| FILED | Tuesday, November 22, 2022 |
| APPL NO | 17/992555 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/018 (20130101) A61B 17/0469 (20130101) A61B 17/0485 (20130101) A61B 17/0487 (20130101) Original (OR) Class A61B 2017/0034 (20130101) A61B 2017/0488 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230116229 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Chunghorng Liu (West Lafayette, Indiana); Siyu Liu (West Lafayette, Indiana) |
| ABSTRACT | A method of selectively controlling materials structure in solution based chemical synthesis and deposition of materials by controlling input energy from pulsed energy source includes determining solution conditions, searching and/or determining energy barrier(s) of a desired materials structure formation, applying precursor solution with selected solution condition onto a substrate, and applying determined input energy from a pulsed energy source with a selected condition to the substrate, thereby nucleating and growing the crystal. |
| FILED | Tuesday, November 22, 2022 |
| APPL NO | 17/992819 |
| CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 25/16 (20130101) Original (OR) Class C30B 29/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230116271 | Sharma et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NORTH CAROLINA STATE UNIVERSITY (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nitin Sharma (Raleigh, North Carolina); Qiang Zhang (Raleigh, North Carolina); Albert Dodson (Raleigh, North Carolina); Ashwin Iyer (Raleigh, North Carolina) |
| ABSTRACT | Systems and methods for closed-loop ultrasound imaging-based control are described herein. An example system includes an ultrasound transducer, and a controller operably coupled to the ultrasound transducer. The controller includes a processor and memory, the memory having computer-executable instructions stored thereon. The controller is configured to receive an ultrasound imaging signal associated with a subject's muscular activity from the ultrasound transducer; process the ultrasound imaging signal to obtain a feedback signal; and control a device interfacing with the subject based on the feedback signal. |
| FILED | Tuesday, October 04, 2022 |
| APPL NO | 17/937946 |
| CURRENT CPC | Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 1/0266 (20130101) A61H 3/00 (20130101) A61H 2201/5005 (20130101) A61H 2201/5058 (20130101) A61H 2201/5061 (20130101) A61H 2201/5069 (20130101) A61H 2201/5084 (20130101) A61H 2205/12 (20130101) A61H 2230/085 (20130101) A61H 2230/605 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/36003 (20130101) A61N 1/36031 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230116607 | Talukdar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonti Talukdar (Durham, North Carolina); Krishnendu Chakrabarty (Durham, North Carolina) |
| ABSTRACT | An integrated circuit (IC) protection circuit for an IC includes a controller with a barrier finite state machine (FSM) having a key sequence input that unlocks the controller; and a signal scrambler coupled to receive at least two initialization inputs and a primary input path and output a signal to the IC, wherein at least one initialization input of the at least two initialization inputs is based on an output of the barrier FSM. The IC protection circuit can further include a dynamic authentication circuit coupled to receive the output of the barrier finite state machine and output a signal to the signal scrambler for one of the at least two initialization inputs. The dynamic authentication circuit can be formed of a dynamic sequence generator and a dynamic sequence authenticator, each formed of one or more reconfigurable linear feedback shift registers, and a comparator. |
| FILED | Thursday, October 07, 2021 |
| APPL NO | 17/496055 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/75 (20130101) Original (OR) Class Static Stores G11C 29/36 (20130101) G11C 2029/3602 (20130101) Pulse Technique H03K 19/21 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20230110061 | Galigekere et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Veda Galigekere (Oak Ridge, Tennessee); Subhajyoti Mukherjee (Kharagpur, India) |
| ABSTRACT | A system and method for controlling output power in an LCC-series wireless power system based on one or more primary-side variables, such as a peak voltage in the LCC-series compensation circuitry. |
| FILED | Tuesday, October 04, 2022 |
| APPL NO | 17/959552 |
| CURRENT CPC | Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 53/122 (20190201) Original (OR) Class B60L 2210/42 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 7/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230110210 | DAHLIN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lukas Royce DAHLIN (Golden, Colorado); Michael T. GUARNIERI (Denver, Colorado) |
| ABSTRACT | Phosphite dehydrogenase (ptxD) expression was established as a selectable marker for nuclear and chloroplast genetic selection in Picochlorum renovo and Picochlorum celeri Phosphite was used as a sole phosphorus source in P. renovo and P. celeri. Growth on phosphite led to comparable growth and composition relative to phosphate. |
| FILED | Friday, September 23, 2022 |
| APPL NO | 17/951848 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/12 (20130101) Original (OR) Class C12N 9/0004 (20130101) C12N 15/8214 (20130101) C12N 15/8243 (20130101) C12N 2800/10 (20130101) Enzymes C12Y 120/01001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230110247 | Khare et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | Intel Corporation (Santa Clara, California) |
| INVENTOR(S) | Surhud Khare (Bangalore, India); Dinesh Somasekhar (Portland, None); Shekhar Y. Borkar (Beaverton, None) |
| ABSTRACT | Described is an apparatus which comprises: a first die including: a processing core; a crossbar switch coupled to the processing core; and a first edge interface coupled to the crossbar switch; and a second die including: a first edge interface positioned at a periphery of the second die and coupled to the first edge interface of the first die, wherein the first edge interface of the first die and the first edge interface of the second die are positioned across each other; a clock synchronization circuit coupled to the second edge interface; and a memory interface coupled to the clock synchronization circuit. |
| FILED | Monday, October 31, 2022 |
| APPL NO | 17/977236 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/78 (20130101) H01L 23/53238 (20130101) Original (OR) Class H01L 23/53295 (20130101) H01L 2924/00 (20130101) H01L 2924/0002 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 257/92 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230110264 | Ciocys et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Samuel Ciocys (Berkeley, California); Alessandra Lanzara (Piedmont, California) |
| ABSTRACT | A source and drain electrode are spaced apart by an optically exposed gate region above a surface photovoltage effect (SPV) bulk. A two-dimensional material is deposited upon the gate region. The gate region is activated by exposure to an ultrafast light pulse, which may be infrared or near-infrared, and may be a focused collimated laser pulse with a sub-picosecond width. The pulse causes electron-hole pair generation resulting in band bending in the SPV material, which generates an electric field within the 2D material, thereby modifying the electronic properties between source and drain via a field-effect. After passage of the pulse, conduction continues in the device until the conductive electron-hole pairs recombine during the SPV decay time. The two-dimensional material may comprise a crystalline atomic monolayer. The activation is repeatable with subsequent pulses, resulting in the device cycling on and off within timescales less than 200 picoseconds. |
| FILED | Friday, September 09, 2022 |
| APPL NO | 17/930760 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/112 (20130101) Original (OR) Class H01L 31/113 (20130101) H01L 31/0336 (20130101) H01L 31/035209 (20130101) Pulse Technique H03K 17/56 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230110470 | Stechel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ellen B. Stechel (Albuquerque, New Mexico); Ivan Ermanoski (Tempe, Arizona); Shuguang Deng (Mesa, Arizona); Mai Xu (Piscataway, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ellen B. Stechel (Albuquerque, New Mexico); Ivan Ermanoski (Tempe, Arizona); Shuguang Deng (Mesa, Arizona); Mai Xu (Piscataway, New Jersey) |
| ABSTRACT | Separating oxygen from a gas includes contacting an oxygen-selective sorbent with a gas stream, adsorbing oxygen in the gas stream with the sorbent, heating the sorbent to greater than 400° C., and desorbing a majority of the oxygen. The sorbent is selective for oxygen, and adsorbing occurs at a temperature between 275-325° C. An oxygen separation system includes a sorption bed, a heater configured to heat the sorption bed, an oxygen analyzer, a first conduit configured provide an input gas to the sorption bed, a second conduit configured to provide processed input gas from the sorption bed to the oxygen analyzer, a third conduit configured to provide a purge gas to the sorption bed, and a fourth conduit configured to provide processed purge gas to the oxygen analyzer. The first and third conduits are configured to flow the input gas and the purge gas flow in opposite directions through the sorption bed. |
| FILED | Thursday, September 01, 2022 |
| APPL NO | 17/901537 |
| CURRENT CPC | Separation B01D 53/0462 (20130101) Original (OR) Class B01D 2253/112 (20130101) B01D 2256/10 (20130101) B01D 2257/104 (20130101) B01D 2259/45 (20130101) B01D 2259/40009 (20130101) B01D 2259/40056 (20130101) B01D 2259/40081 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/04 (20130101) B01J 20/0207 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230110739 | WELLONS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BATTELLE SAVANNAH RIVER ALLIANCE, LLC (AIKEN, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | MATTHEW S. WELLONS (AIKEN, South Carolina); MICHAEL A. DEVORE, II (NORTH AUGUSTA, South Carolina); WENDY W. KUHNE (EVANS, Georgia) |
| ABSTRACT | Methods for forming particulates that are highly consistent with regard to shape, size, and content are described. Particulates are suitable for use as reference materials. Methods can incorporate actinides and/or lanthanides, e.g., uranium, and can be used for forming certified reference materials for use in the nuclear industry. Methods include formation of an aerosol from an oxalate salt solution, in-line diagnostics, and collection of particles of the aerosol either in a liquid impinger or on a solid surface. |
| FILED | Tuesday, December 13, 2022 |
| APPL NO | 18/079923 |
| CURRENT CPC | Processes for Applying Fluent Materials to Surfaces, in General B05D 1/06 (20130101) Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 9/026 (20130101) B22F 2202/06 (20130101) B22F 2301/45 (20130101) Production and Refining of Metals; Pretreatment of Raw Materials C22B 60/0217 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/46 (20130101) C23C 24/00 (20130101) Nuclear Reactors G21C 3/60 (20130101) Original (OR) Class G21C 3/623 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/12056 (20150115) Y10T 428/12063 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230110835 | Seeley et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zachary Seeley (Livermore, California); Nerine Cherepy (Piedmont, California); Alexander Drobshoff (Livermore, California); Stephen Anthony Payne (Castro Valley, California); Ian Robert Phillips (Sunnyvale, California); Thomas John Rudzik (Livermore, California) |
| ABSTRACT | A method for forming a transparent ceramic, in accordance with one embodiment, includes forming a green body by material jetting an ink, and processing the green body to form the ceramic to transparency. A product, in accordance with one embodiment, includes an ink for forming a transparent ceramic. The ink is physically characterized as having a density, surface tension, and viscosity configured to enable material jetting of the ink in contained, sequential droplets having a volume in the range of about 1 picoliter to about 1 nanoliter when jetted from a nozzle having an inner diameter in the range of about 10 microns to about 300 microns. A product, in accordance with another embodiment, includes a transparent ceramic, at least a portion of the transparent ceramic having layers of less than 50 microns per layer with physical characteristics of formation by material jetting. |
| FILED | Wednesday, October 12, 2022 |
| APPL NO | 17/964735 |
| CURRENT CPC | Shaping Clay or Other Ceramic Compositions; Shaping Slag; Shaping Mixtures Containing Cementitious Material, e.g Plaster B28B 1/001 (20130101) Printing, Duplicating, Marking, or Copying Processes; Colour Printing, B41M 5/0047 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/36 (20130101) Original (OR) Class C09D 11/38 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230110869 | Merchant et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Sabeeha S. Merchant (Berkeley, California); Sean David Gallaher (Berkeley, California); Jeffrey L. Moseley (Berkeley, California) |
| ABSTRACT | Multiple exogenous genes are expressed from a single transcript in algae and plants using engineered plant polycistronic loci. |
| FILED | Tuesday, December 13, 2022 |
| APPL NO | 18/065615 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8216 (20130101) Original (OR) Class C12N 15/8274 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230111862 | CUI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado); Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shuang CUI (Dallas, Texas); Charles William BOOTEN (Arvada, Colorado); Judith Cecilia VIDAL (Littleton, Colorado); Yudong LI (Golden, Colorado); Kyle Edward O'Neil FOSTER (Denver, Colorado); Xiaowen CHEN (Arvada, Colorado); Kelsey Mary LYNCH (Denver, Colorado); Hongbing LU (Plano, Texas); Bernadette Karen MAGALINDAN (Dallas, Texas); Gustavo Felicio PERRUCI (Richardson, Texas) |
| ABSTRACT | The present disclosure relates to wood template-supported phase change material (PCM) composites having thermal energy storage applications. A wood template-supported PCM composite may include a wood template that has had at least a portion of its xylan and/or lignin removed and saturated with a PCM. The PCM may be stabilized with a cross linkable network for improved infiltration into the wood template. The wood template-supported PCM composite may be formed by extracting xylan and/or lignin from the wood to create a wood template, densifying at least a portion of the wood template, and inserting a PCM into the wood template. |
| FILED | Friday, September 30, 2022 |
| APPL NO | 17/936925 |
| CURRENT CPC | Processes, Apparatus or Selection of Substances for Impregnating, Staining, Dyeing, Bleaching of Wood or Similar Materials, or Treating of Wood or Similar Materials With Permeant Liquids, Not Otherwise Provided for; Chemical or Physical Treatment of Cork, Cane, Reed, Straw or Similar Materials B27K 3/15 (20130101) B27K 3/0207 (20130101) Original (OR) Class B27K 5/001 (20130101) B27K 5/007 (20130101) B27K 2240/10 (20130101) B27K 2240/60 (20130101) Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 20/023 (20130101) F28D 2020/0017 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20230112681 — STABLE IMMOBILIZED AMINE SORBENTS FOR REE AND HEAVY METAL RECOVERY FROM LIQUID SOURCES
| US 20230112681 | Gray et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Department of Energy (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | McMahan L. Gray (Pittsburgh, Pennsylvania); Brian W. Kail (Pittsburgh, Pennsylvania); Walter C. Wilfong (Jefferson Hills, Pennsylvania); Qiuming Wang (South Park, Pennsylvania) |
| ABSTRACT | Materials, methods of making, and methods of using a stable and regenerable immobilized amine sorbents for rare earth element and heavy metal recovery from liquid sources. Embodiments of the invention relate to the novel combination of different polyamines, primarily polyethylenimine Mw=800 (PEI800), and an epoxysilane, namely 2-(3,4-epoxycyclohexyl)ethyltrimethoxysilane (ECTMS), covalently immobilizing theREE and heavy metal-adsorbing amine sites within low cost, porous silica particles. |
| FILED | Tuesday, November 22, 2022 |
| APPL NO | 17/992617 |
| CURRENT CPC | Compounds of the Metals Beryllium, Magnesium, Aluminium, Calcium, Strontium, Barium, Radium, Thorium, or of the Rare-earth Metals C01F 11/005 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/0812 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 73/0206 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/36 (20130101) C08K 5/5419 (20130101) C08K 7/14 (20130101) Compositions of Macromolecular Compounds C08L 79/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230113026 | Zhu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ying Zhu (Richland, Washington); James M. Fulcher (Pasco, Washington); Lye Meng Markillie (Richland, Washington); Ljiljana Pasa-Tolic (Richland, Washington) |
| ABSTRACT | Methods for performing multiple omics analysis in parallel are provided, the methods can include: dividing the mixture of cells or cell components into at least a first portion and a second portion; performing a first analysis on the first portion to acquire a first set of analytical data; performing a second analysis on the second portion to acquire a second set of analytical data. Methods for forming mixtures of analytes into first and second portions are also provided. The methods can include aligning the first and second plates to engage the first exposed surface with the second exposed surface, wherein the engaging is sufficient to convey at least some of the first analytes into the second solution to form a second mixture of the first analytes. |
| FILED | Wednesday, September 28, 2022 |
| APPL NO | 17/954834 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502784 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/08 (20130101) G01N 2030/062 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230113164 | Epps, III et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Thomas H. Epps, III (Bear, Delaware); Angela L. Holmberg (Somerville, Massachusetts); Kaleigh H. Nicastro (Newark, Delaware); Shu Wang (Newark, Delaware); Basudeb Saha (Newark, Delaware); Li Shuai (Blacksburg, Virginia); Dionisios G. Vlachos (Newark, Delaware); Melody A. Morris (Elkton, Maryland) |
| ASSIGNEE(S) | University of Delaware (Newark, Delaware) |
| INVENTOR(S) | Thomas H. Epps, III (Bear, Delaware); Angela L. Holmberg (Somerville, Massachusetts); Kaleigh H. Nicastro (Newark, Delaware); Shu Wang (Newark, Delaware); Basudeb Saha (Newark, Delaware); Li Shuai (Blacksburg, Virginia); Dionisios G. Vlachos (Newark, Delaware); Melody A. Morris (Elkton, Maryland) |
| ABSTRACT | Disclosed herein is a bio-based copolymer comprising in polymerized form (i) at least one polymerizable bio-based monomer containing one phenolic hydroxyl group which has been derivatized to provide at least one polymerizable functional group which is an ethylenically unsaturated functional group (such as a [meth]acrylate group), where the precursors of the polymerizable bio-based monomers are derived from raw lignin-containing biomass, and (ii) at least one ion-conducting co-monomer other than the bio-based monomer. Also disclosed herein are binders comprising the bio-based copolymer, electrodes comprising the binder, polymer electrolytes comprising the bio-based copolymer and an electrochemical device comprising an electrode in electrical contact with a polymer electrolyte, wherein at least one of the electrode and the polymer electrolyte comprises the bio-based copolymer. |
| FILED | Friday, November 04, 2022 |
| APPL NO | 17/980792 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 27/302 (20130101) B32B 27/308 (20130101) Acyclic or Carbocyclic Compounds C07C 41/18 (20130101) C07C 41/38 (20130101) C07C 67/14 (20130101) C07C 69/618 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 293/005 (20130101) Original (OR) Class C08F 2438/01 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 83/005 (20130101) C08G 2170/40 (20130101) Derivatives of Natural Macromolecular Compounds C08H 8/00 (20130101) Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 7/38 (20180101) C09J 7/385 (20180101) C09J 7/387 (20180101) C09J 9/02 (20130101) C09J 125/18 (20130101) C09J 133/08 (20130101) C09J 153/00 (20130101) C09J 2203/33 (20130101) C09J 2301/414 (20200801) C09J 2400/163 (20130101) C09J 2400/226 (20130101) C09J 2400/283 (20130101) C09J 2433/00 (20130101) C09J 2453/00 (20130101) C09J 2471/00 (20130101) C09J 2497/00 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/622 (20130101) H01M 10/0565 (20130101) H01M 2300/0082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230114017 | Brocato et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert W. Brocato (Sandia Park, New Mexico); Michael P. Frank (Albuquerque, New Mexico) |
| ABSTRACT | An adiabatic resonator, an adiabatic oscillator, and an adiabatic oscillator system are disclosed. An adiabatic system is one that ideally transfers no heat outside of the system, thereby reducing the required operating power. The adiabatic resonator, which includes a plurality of tank circuits, acts as an energy reservoir, the missing aspect of previously attempted adiabatic computational systems. By using the adiabatic resonator as a feedback element with an amplifier, an adiabatic oscillator is formed. An adiabatic oscillator system is formed with a primary adiabatic oscillator feeding a plurality of secondary adiabatic oscillators. In this manner, the adiabatic oscillator system may be used to generate the multiple clock signals required of adiabatic computational logic elements, such as Split-level Charge Recovery Logic and 2-Level Adiabatic Logic. The adiabatic oscillator system stores enough energy to drive many individual adiabatic computational logic elements, permitting implementation of complex logic circuits. |
| FILED | Thursday, August 19, 2021 |
| APPL NO | 17/406240 |
| CURRENT CPC | Generation of Oscillations, Directly or by Frequency-changing, by Circuits Employing Active Elements Which Operate in a Non-switching Manner; Generation of Noise by Such Circuits H03B 5/12 (20130101) Original (OR) Class Amplifiers H03F 3/2176 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230114099 | White et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregory K. White (Livermore, California); Steven A. Kreek (Livermore, California) |
| ABSTRACT | An incident exercise system supports an incident exercise. The incident exercise system accesses an exercise plan defining an incident within a theater of operation. The incident exercise system administers the incident exercise by generating detector signals factoring in incident effects and characteristic effects of the theater of operation. The incident exercise system sends detector signals to detectors that filter effect of background noise from the detector signals to generate filtered detector signals and output data derived from the filtered detector signals. The incident exercise system supports dynamically modifying the exercise plan during the incident exercise. |
| FILED | Thursday, October 07, 2021 |
| APPL NO | 17/496073 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/20 (20200101) Original (OR) Class Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 50/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230114948 | Mohite et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | William Marsh Rice University (Houston, Texas) |
| ASSIGNEE(S) | William Marsh Rice University (Houston, Texas) |
| INVENTOR(S) | Aditya D. Mohite (Houston, Texas); Michael Wong (Houston, Texas); Austin Fehr (Houston, Texas); Ayush Agrawal (Houston, Texas); Faiz Mandani (Houston, Texas) |
| ABSTRACT | A multicomponent conductive adhesive barrier includes an adhesive layer and a conductive barrier. The adhesive layer includes a doped pressure-sensitive adhesive and the conductive barrier layer is a carbon or metal-based material. A photoelectrode structure includes a substrate, a photoabsorbing layer, a multicomponent conductive adhesive barrier, and an electrocatalyst. A method for fabricating the photoelectrode structure includes applying a photoabsorbing layer to a substrate, preparing an adhesive layer, and forming a multicomponent conductive adhesive barrier by applying a conductive barrier layer to the adhesive layer. |
| FILED | Tuesday, October 11, 2022 |
| APPL NO | 18/045710 |
| CURRENT CPC | Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 9/20 (20130101) H01G 9/048 (20130101) Original (OR) Class H01G 9/0425 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230115297 | TENNANT |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | JEFFERSON SCIENCE ASSOCIATES, LLC (Newport News, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | CHRISTOPHER TENNANT (WILLIAMSBURG, Virginia) |
| ABSTRACT | A method or tool for an efficient, data-driven approach to beam tuning in particle accelerators that leverages deep learning over structured data. A beamline is represented as a graph, where individual elements are nodes and relationships between elements are edges. Element parameters are captured as node features. A graph neural network is used to generate a whole-graph embedding that preserves structural information, and dimensionality reduction techniques are applied to visualize low-dimensional representations. Providing a category label for each embedding to identify optimal regions of parameter space. The method serves as a global diagnostic, inasmuch as it monitors a high-dimensional space and provides feedback to operators when changes are made. Operators can track if changes during beam tuning move the configuration away or towards optimal regions of parameter space. On-line and off-line tool embodiments of the beam tuning tool are described. |
| FILED | Monday, October 03, 2022 |
| APPL NO | 17/958555 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/0895 (20230101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230115755 | Sava Gallis et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dorina F. Sava Gallis (Albuquerque, New Mexico); Kimberly S. Butler (Albuquerque, New Mexico) |
| ABSTRACT | A rapid and facile design strategy to create a highly complex optical tag with programmable, multimodal photoluminescent properties is described. This is achieved via intrinsic and biomolecule-fluorophore hidden signatures. As a first covert feature of the tag, an intricate novel heterometallic near-infrared (NIR) emitting mesoporous metal-organic framework (MOF) was synthesized comprising homometallic hexanuclear clusters based on Nd and Yb. To generate controlled, multimodal, and tailorable emission with difficult to counterfeit features, the NIR emissive MOF was post-synthetically modified via a fluorescent biomolecule labeling design strategy. The surface attachment of several distinct fluorophores, including the simultaneous attachment of up to three distinct fluorescently labeled DNA oligos was demonstrated, with excitation and emission properties across the visible spectrum (480-800 nm). The DNA inclusion as a secondary covert element in the tag was demonstrated via detection of SYBR Gold dye association. |
| FILED | Tuesday, December 13, 2022 |
| APPL NO | 18/080051 |
| CURRENT CPC | Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 57/00 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) C09K 2211/182 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6816 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 33/582 (20130101) G01N 2021/6439 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230115891 | Murialdo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Maxwell Murialdo (Westminster, California); Wenqin Li (Fremont, California); Diego I. Oyarzun Dinamarca (Livermore, California); Paul J. Durack (Livermore, California) |
| ABSTRACT | A direct air capture system for use in a body of water that has waves with wave motion. The system includes at least one module exposed to the waves. The relative motion between the module and the waves to draws air into the module. The system removes carbon dioxide from the air using a moisture swing absorbent to remove the carbon dioxide from the air. The removed carbon dioxide can be used for various purposes. |
| FILED | Thursday, October 06, 2022 |
| APPL NO | 17/938384 |
| CURRENT CPC | Separation B01D 1/0035 (20130101) B01D 5/006 (20130101) B01D 53/62 (20130101) B01D 53/82 (20130101) B01D 53/96 (20130101) B01D 53/0446 (20130101) Original (OR) Class B01D 2253/206 (20130101) B01D 2258/06 (20130101) B01D 2259/40083 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/55 (20170801) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/14 (20130101) C02F 2103/08 (20130101) Machines or Engines for Liquids F03B 13/14 (20130101) Pumping of Fluid by Direct Contact of Another Fluid or by Using Inertia of Fluid to be Pumped; Siphons F04F 10/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230116165 | Lukens et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| INVENTOR(S) | Joseph M. Lukens (Knoxville, Tennessee); Nicholas A. Peters (Knoxville, Tennessee); Raphael C. Pooser (Knoxville, Tennessee) |
| ABSTRACT | A nonlinear fiber interferometer is disclosed suitable for fiber sensor and other applications. A first nonlinear fiber section amplifies probe and conjugate sidebands of a pump through four-wave mixing. A second section introduces a phase shift to be measured, for example from a sensor. A third nonlinear fiber section amplifies with phase-sensitive gain to increase signal-to-noise ratio. Based on phase-sensitive output power of probe and/or conjugate components, the phase shift can be measured. Superior performance can be obtained by balancing gain between the (first and third) nonlinear sections. Non-fiber, for example photonic integrated circuit, embodiments are disclosed. Differential sensing, alternative detection schemes, sensing applications, associated methods, and other variations are disclosed. |
| FILED | Monday, August 01, 2022 |
| APPL NO | 17/878325 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/39 (20130101) Original (OR) Class G02F 1/392 (20210101) G02F 1/3501 (20130101) G02F 1/3507 (20210101) G02F 1/3544 (20130101) G02F 2203/13 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230116361 | Lynn et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Other Lab, LLC (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter Sturt Lynn (Alameda, California); Jonathan B. Pompa (Long Beach, California) |
| ABSTRACT | An anchor installation vehicle that includes a vehicle frame having a top end and bottom end, one or more rotational thrusters, and an anchor system configured to hold an anchor extending from the bottom end of the vehicle frame. |
| FILED | Tuesday, December 13, 2022 |
| APPL NO | 18/080491 |
| CURRENT CPC | Ships or Other Waterborne Vessels; Equipment for Shipping B63B 21/20 (20130101) B63B 21/26 (20130101) B63B 79/10 (20200101) B63B 79/40 (20200101) Original (OR) Class Marine Propulsion or Steering B63H 11/00 (20130101) Foundations; Excavations; Embankments; Underground or Underwater Structures E02D 5/801 (20130101) E02D 7/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230116443 | Kirsch et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kathryn L. Kirsch (Manchester, Connecticut); Robert H. Dold (Monson, Massachusetts); Paul Attridge (Colchester, Connecticut); Alexandru Cadar (Eastford, Connecticut); Joseph Turney (Amston, Connecticut); Ram Ranjan (West Hartford, Connecticut) |
| ABSTRACT | A header for a high-pressure heat exchanger includes a first high-pressure transition section with inlets for multiple first high-pressure flow channels that are spaced from one another in a radial direction and collectively arranged in a substantially circular shape. The inlets for the multiple first high-pressure flow channels on a radially outer edge of the first high-pressure transition section are spaced further apart in a circumferential direction from adjacent inlets of the multiple first high-pressure flow channels than radially inward inlets are spaced from adjacent radially inward inlets of the multiple first high-pressure flow channels. The header also includes multiple first high-pressure flow channels extending from the first high-pressure transition section to a second-high pressure transition section that is configured to divide each of the multiple first high-pressure flow channels into at least two first high-pressure sub-flow channels. |
| FILED | Tuesday, October 04, 2022 |
| APPL NO | 17/959399 |
| CURRENT CPC | Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 9/0275 (20130101) Original (OR) Class F28F 2009/0287 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230116532 | Nojima |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Eaton Intelligent Power Limited (Dublin 4, Ireland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Geraldo Nojima (Matthews, North Carolina) |
| ABSTRACT | A system for high-voltage interconnecting and interfacing can include: a package for a circuit, wherein the package comprises a housing for the circuit; and a gate connector located centrally on a face of an exterior surface of the housing, wherein the gate connector enables wiring outside the package to couple to the gate connector from any of a plurality of directions. In certain embodiments, the package for the housing further comprises a pressure applicator about an exterior surface of the housing; and the system further comprises a leadline that extends from the circuit within the housing and beyond the exterior surface through an aperture in the housing, wherein the leadline can be deformed over the pressure applicator at the exterior surface such that the pressure applicator can apply pressure to the leadline against a contact surface of a second structure. |
| FILED | Wednesday, October 12, 2022 |
| APPL NO | 17/964360 |
| CURRENT CPC | Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors H01R 4/48 (20130101) H01R 13/20 (20130101) Original (OR) Class H01R 13/187 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20230110619 | Khanicheh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | EnVision Endoscopy, Inc. (Somerville, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Azadeh Khanicheh (Somerville, Massachusetts); Amos G. Cruz (Wrentham, Massachusetts); Judy Walish (Boston, Massachusetts) |
| ABSTRACT | A method cinches a suture. The method provides a cinch having a suture capturing portion configured to capture a suture, a cinch lock coupled with the suture capturing portion, and a cinch anchor having a lumen. The suture capturing portion is extended out of the lumen to capture the suture. The suture is captured by the suture capturing portion. The suture capturing portion is retracted into the lumen of the cinch anchor. The suture is cinched between the cinch lock and the cinch anchor. |
| FILED | Monday, November 21, 2022 |
| APPL NO | 17/991526 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/0401 (20130101) A61B 17/0469 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230114728 | BURNS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Venatorx Pharmaceuticals, Inc. (Malvem, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher J. BURNS (Malvern, Pennsylvania); Denis DAIGLE (Street, Maryland); Guo-Hua CHU (Exton, Pennsylvania); Jodie HAMRICK (New Holland, Pennsylvania); Steven A. BOYD (Chester Springs, Pennsylvania); Allison L. ZULLI (Chesterbrook, Pennsylvania); Stephen M. CONDON (Glenmoore, Pennsylvania); Cullen L. MYERS (Phoenixville, Pennsylvania); Zhenrong XU (Chalfont, Pennsylvania); Tsuyoshi Uehara (Berwyn, Pennsylvania); Nathan LINE (Royersford, Pennsylvania) |
| ABSTRACT | Described herein are certain boron-containing compounds, compositions, preparations and their use as modulators of the transpeptidase function of bacterial penicillin-binding proteins and as antibacterial agents. In some embodiments, the compounds described herein inhibit penicillin-binding proteins. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections. |
| FILED | Thursday, September 24, 2020 |
| APPL NO | 17/779804 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/20 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230114970 | Quigley et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Loci Controls, Inc. (Wareham, Massachusetts) |
| ASSIGNEE(S) | Loci Controls, Inc. (Wareham, Massachusetts) |
| INVENTOR(S) | Peter Quigley (Duxbury, Massachusetts); Ian Martin (Sharon, Massachusetts); Nicole Neff (North Potomac, Maryland); Jack Rowbottom (Swansea, Massachusetts) |
| ABSTRACT | A control system for controlling extraction of landfill gas from a landfill via a gas extraction system, the gas extraction system comprising well piping for coupling a plurality of wells to a gas output. The control system comprises a controller configured to: obtain a value indicating measured energy content of landfill gas collected at the gas output from the plurality of wells; determine whether the measured energy content is different from a target energy content; and in response to determining that the measured energy content is different from the target energy content: control a plurality of valves disposed in the well piping to change flow rates of landfill gas being extracted from at least some of the plurality of wells at least in part by changing degrees to which the plurality of valves are open. |
| FILED | Tuesday, October 04, 2022 |
| APPL NO | 17/959446 |
| CURRENT CPC | Disposal of Solid Waste B09B 1/006 (20130101) Original (OR) Class Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 34/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230116147 | Watkins |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ORB Technologies, LLC (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Virginia Watkins (Lexington, Kentucky) |
| ABSTRACT | An apparatus for resisting a gravity load is disclosed. The apparatus has a first end member, a second end member, and a plurality of elongated structural members, each of the plurality of elongated structural members including a first end portion attached to the first end member and a second end portion attached to the second end member. The plurality of elongated structural members is oriented to resist compressive stresses or tensile stresses induced by the gravity load. The plurality of elongated structural members is formed from plants with a harvest cycle of four years or fewer. |
| FILED | Thursday, October 07, 2021 |
| APPL NO | 17/496371 |
| CURRENT CPC | Structural Elements; Building Materials E04C 2/16 (20130101) Original (OR) Class E04C 2/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230116167 | Khanicheh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | EnVision Endoscopy, Inc. (Somerville, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Azadeh Khanicheh (Somerville, Massachusetts); Amos G. Cruz (Wrentham, Massachusetts) |
| ABSTRACT | A method cinches a suture. The method provides a cinch having a suture capturing portion configured to capture a suture, a cinch lock coupled with the suture capturing portion, and a cinch anchor having a lumen. The suture capturing portion is extended out of the lumen to capture the suture. The suture is captured by the suture capturing portion. The suture capturing portion is retracted into the lumen of the cinch anchor. The suture is cinched between the cinch lock and the cinch anchor. |
| FILED | Tuesday, November 22, 2022 |
| APPL NO | 17/992555 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/018 (20130101) A61B 17/0469 (20130101) A61B 17/0485 (20130101) A61B 17/0487 (20130101) Original (OR) Class A61B 2017/0034 (20130101) A61B 2017/0488 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20230115147 | Youngblood et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana); United State, as represented by the Secretartary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana); United States, as represented by the Secretary of Agriculture (Washington, District of Columbia) |
| INVENTOR(S) | Jeffrey Paul Youngblood (Crawfordsville, Indiana); Sami Miguel El Awad Azrak (Midland, Michigan); Gregory T. Schueneman (Madison, Wisconsin); Robert John Moon (Marietta, Georgia) |
| ABSTRACT | The present disclosure provides to a novel continuous processing method to prepare sheets comprising cellulose nanofibril (CNF) and carboxymethyl cellulose (CMC). Single screw extrusion was utilized to continuously process mechanically fibrillated cellulose nanofibrils (CNF) into sheets. Water-retention ability and stability of CNF suspensions containing different processing aids was assessed through centrifugation and zeta potential analysis. Subsequently, highly loaded pastes (up to ˜25 wt. % total solids content) containing the best performing processing aids (carboxymethyl cellulose (CMC), xanthan gum (XG), and anionic polyacrylamide (aPAM)) and CNF were prepared using a Brabender with Banbury mixer-head at a dry weight ratio of either 0.1 to 1 or 0.15 to 1, respectively. Validation of the mixing procedure proved that highly loaded CNF pastes can be processed in under 40 minutes, saving up to 40 days in preparation and drying time. |
| FILED | Monday, March 01, 2021 |
| APPL NO | 17/908845 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/18 (20130101) C08J 2301/02 (20130101) C08J 2401/28 (20130101) Compositions of Macromolecular Compounds C08L 1/02 (20130101) Original (OR) Class C08L 2205/16 (20130101) C08L 2205/025 (20130101) Pulp Compositions; Preparation Thereof Not Covered by Subclasses D21C or D21D; Impregnating or Coating of Paper; Treatment of Finished Paper Not Covered by Class B31 or Subclass D21G; Paper Not Otherwise Provided for D21H 11/18 (20130101) D21H 17/26 (20130101) Fibreboard; Manufacture of Articles From Cellulosic Fibrous Suspensions or From Papier-mache D21J 3/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230116147 | Watkins |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ORB Technologies, LLC (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Virginia Watkins (Lexington, Kentucky) |
| ABSTRACT | An apparatus for resisting a gravity load is disclosed. The apparatus has a first end member, a second end member, and a plurality of elongated structural members, each of the plurality of elongated structural members including a first end portion attached to the first end member and a second end portion attached to the second end member. The plurality of elongated structural members is oriented to resist compressive stresses or tensile stresses induced by the gravity load. The plurality of elongated structural members is formed from plants with a harvest cycle of four years or fewer. |
| FILED | Thursday, October 07, 2021 |
| APPL NO | 17/496371 |
| CURRENT CPC | Structural Elements; Building Materials E04C 2/16 (20130101) Original (OR) Class E04C 2/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20230110366 | CARROLL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wake Forest University (Winston-Salem, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David L. CARROLL (Winston-Salem, North Carolina); Chaochao DUN (Winston-Salem, North Carolina); Corey HEWITT (Winston-Salem, North Carolina); Robert SUMMERS (Clemmons, North Carolina) |
| ABSTRACT | Composite nanoparticle compositions and associated nanoparticle assemblies exhibit enhancements to one or more thermoelectric properties including increases in electrical conductivity and/or Seebeck coefficient and/or decreases in thermal conductivity. A composite nanoparticle composition comprises a semiconductor nanoparticle including a front face and a back face and sidewalls extending between the front and back faces. Metallic nanoparticles are bonded to at least one of the sidewalls establishing a metal-semiconductor junction. |
| FILED | Friday, July 01, 2022 |
| APPL NO | 17/856854 |
| CURRENT CPC | Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2004/24 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/881 (20130101) Indexing Scheme Associated With Subclass C10M Relating to Lubricating Compositions C10N 2020/06 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 35/18 (20130101) Original (OR) Class H01L 35/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230114881 | Ting et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | David Z. Ting (Arcadia, California); Sam A. Keo (Pasadena, California); Arezou Khoshakhlagh (Pasadena, California); Alexander Soibel (South Pasadena, California); Sarath D. Gunapala (Stevenson Ranch, California) |
| ABSTRACT | Disclosed herein is an infrared detector. The detector includes a plurality of pixels. Each pixel includes an n-type semiconductor top contact layer, a p-type semiconductor layer electrically connected to the n-type top contact layer to form a top p-n junction, a unipolar electron barrier electrically connected to the p-type semiconductor layer, a bottom absorber, and an n-type semiconductor bottom contact layer electrically connected to the bottom absorber. The unipolar electron barrier is positioned between the p-type semiconductor layer and the bottom absorber. |
| FILED | Friday, October 07, 2022 |
| APPL NO | 17/938838 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/14652 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20230114987 | Mercuri et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Clemson University Research Foundation (Clemson, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeremy J. Mercuri (Piedmont, South Carolina); Richard diMonda (Marietta, Georgia); Matt Pursley (Dawsonville, Georgia); Ishmael Bentley (Edina, Minnesota) |
| ABSTRACT | Integratable treatment devices, assemblies including a treatment device, at least one anchor, and a tether coupled thereto, and various methods and devices for inserting such devices and assemblies are disclosed herein. The treatment devices can be made of an integratable material that is not fully bioresorbable but promotes native tissue growth in and around the material. Certain methods involve first inserting at least one anchor and then advancing a treatment device via a tether coupled to the at least one anchor. Further various insertion devices that can be used to implant any of the treatment devices herein using any of the methods herein are disclosed. |
| FILED | Friday, October 07, 2022 |
| APPL NO | 17/962046 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/0401 (20130101) A61B 2017/0409 (20130101) A61B 2017/0464 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/442 (20130101) Original (OR) Class A61F 2002/4435 (20130101) A61F 2310/00371 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20230113148 | Zlotnick et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Joel Zlotnick (Arlington, Virginia); Jordan Brough (Leesburg, Virginia); Troy Eberhardt (Centreville, Virginia); Tyra McConnell (Knoxville, Maryland); Elizabeth Gil (Bristow, Virginia); Traci Moran (Rockville, Maryland) |
| ABSTRACT | A substrate is printed with front side and back side markings. The front side when viewed with reflected light includes: a first marking printed with a first gradient of two colors; a second marking printed with a second gradient of two colors; a first symbol printed with a third gradient of two colors; a second symbol printed with a fourth gradient of two colors; a third symbol printed with a fifth gradient of two colors; and a fourth symbol printed with a sixth gradient of two colors. The back side when viewed with reflected light includes: a third marking printed with the fourth gradient; a fourth marking printed with the third gradient; a fifth symbol printed with the second gradient; a sixth symbol printed with the first gradient; a seventh symbol printed with the sixth gradient; and an eighth symbol printed with the fifth gradient. |
| FILED | Friday, October 07, 2022 |
| APPL NO | 17/962053 |
| CURRENT CPC | Printing, Duplicating, Marking, or Copying Processes; Colour Printing, B41M 3/148 (20130101) B41M 2205/34 (20130101) Indexing Scheme Relating to Printing, Lining Machines, Typewriters, and to Stamps B41P 2227/10 (20130101) Books; Book Covers; Loose Leaves; Printed Matter Characterised by Identification or Security Features; Printed Matter of Special Format or Style Not Otherwise Provided For; Devices for Use Therewith and Not Otherwise Provided For; Movable-strip Writing or Reading Apparatus B42D 25/29 (20141001) Original (OR) Class B42D 25/333 (20141001) B42D 25/405 (20141001) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20230114037 | SONG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States GOVERNMENT As Represented By The Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | MOON K. SONG (Washington, District of Columbia); DAVID S. BISCHOFF (Washington, District of Columbia); DEAN T. YAMAGUCHI (Washington, District of Columbia); KOICHI UYEMURA (Washington, District of Columbia); RAM PYARE SINGH (Washington, District of Columbia) |
| ABSTRACT | Prevention and treatment of immune deficiency and inflammation using cyclic histidyl-proline plus zinc (Cyclo-Z). |
| FILED | Friday, September 30, 2022 |
| APPL NO | 17/957715 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/48 (20130101) A61K 9/0053 (20130101) A61K 33/30 (20130101) A61K 38/12 (20130101) Original (OR) Class A61K 47/547 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Environmental Protection Agency (EPA)
| US 20230110361 | Jun et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Young-Shin Jun (St. Louis, Missouri); Doyoon Kim (St. Louis, Missouri); Albern X. Tan (St. Louis, Missouri) |
| ABSTRACT | The present disclosure relates to biodegradable materials and methods of removing using the biodegradable materials to remove phosphorus from water. Additionally, the biodegradable materials may be used as a fertilizer. |
| FILED | Wednesday, September 14, 2022 |
| APPL NO | 17/944820 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/24 (20130101) Original (OR) Class B01J 20/048 (20130101) B01J 20/3208 (20130101) B01J 20/28016 (20130101) B01J 20/28047 (20130101) B01J 2220/46 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/288 (20130101) C02F 2103/06 (20130101) Phosphatic Fertilisers C05B 17/00 (20130101) Inorganic Fertilisers Not Covered by Subclasses C05B, C05C; Fertilisers Producing Carbon Dioxide C05D 9/02 (20130101) Mixtures of Fertilisers Covered Individually by Different Subclasses of Class C05; Mixtures of One or More Fertilisers With Materials Not Having a Specific Fertilising Activity, e.g Pesticides, Soil-conditioners, Wetting Agents; Fertilisers Characterised by Their Form C05G 5/18 (20200201) C05G 5/40 (20200201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20230110875 | Orentas et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as Presented by the Secretary, Department of Health (Bethesda, Maryland); BIOMED VALLEY DISCOVERIES, INC. (Kansas City, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rimas J. Orentas (Chevy Chase, Maryland); Zhongyu Zhu (Frederick, Maryland); Crystal L. Mackall (Bethesda, Maryland); Dimiter S. Dimitrov (Frederick, Maryland); Bradley St. Croix (Frederick, Maryland); Saurabh Saha (Leawood, Kansas) |
| ABSTRACT | Polypeptides and proteins that specifically bind to and immunologically recognize CD276 are disclosed. Chimeric antigen receptors (CARs), anti-CD276 binding moieties, nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions relating to the polypeptides and proteins are also disclosed. Methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal are also disclosed. |
| FILED | Tuesday, October 25, 2022 |
| APPL NO | 18/049470 |
| CURRENT CPC | Peptides C07K 16/30 (20130101) Original (OR) Class C07K 16/2827 (20130101) C07K 2317/21 (20130101) C07K 2317/33 (20130101) C07K 2317/73 (20130101) C07K 2317/92 (20130101) C07K 2317/622 (20130101) C07K 2319/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57492 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230111174 | Zaykov et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell International s.r.o. (Praha 4 - Chodov, Czech Republic) |
| ASSIGNEE(S) | Honeywell International s.r.o. (Praha 4 - Chodov, Czech Republic) |
| INVENTOR(S) | Pavel Zaykov (Brno, Czech Republic); Humberto Carvalho (Vila Real, Czech Republic); Larry James Miller (Black Canyon City, Arizona) |
| ABSTRACT | Systems and methods for regulating memory utilization for coprocessors are provided. In one embodiment, a computing system comprises: a processor; a compute processor configured to execute one or more kernels; a memory coupled to the processor and the compute processor. The system is configured to: allocate at least one task memory transaction quota to at least a first set of tasks executed on a first core of the processor; allocate at least one compute processor memory transaction quota for executing the kernels on the compute processor; execute within a first timing window iteration the first set of tasks and the kernels, wherein the kernels are executed during the first timing window iteration until the compute memory transaction quota is depleted; and regulate a rate of memory transaction access by the one or more kernels to the memory when the first set of tasks are executing on the processor. |
| FILED | Wednesday, October 13, 2021 |
| APPL NO | 17/500552 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/467 (20130101) G06F 9/5016 (20130101) Original (OR) Class G06F 9/5038 (20130101) Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, April 13, 2023.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20230413.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page