FedInvent™ Patent Applications
Application Details for Thursday, April 20, 2023
This page was updated on Thursday, April 20, 2023 at 05:28 AM GMT
Department of Health and Human Services (HHS)
| US 20230116968 | Lock et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin Lock (Southampton, Pennsylvania); Luc H. Vandenberghe (Weston, Massachusetts); James M. Wilson (Philadelphia, Pennsylvania) |
| ABSTRACT | A method for producing AAV, without requiring cell lysis, is described. The method involves harvesting AAV from the supernatant. For AAV having capsids with a heparin binding site, the method involves modifying the AAV capsids and/or the culture conditions to ablate the binding between the AAV heparin binding site and the cells, thereby allowing the AAV to pass into the supernatant, i.e., media. Thus, the method of the invention provides supernatant containing high yields of AAV which have a higher degree of purity from cell membranes and intracellular materials, as compared to AAV produced using methods using a cell lysis step. |
| FILED | Wednesday, June 08, 2022 |
| APPL NO | 17/806005 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/0091 (20130101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class C12N 2750/14151 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230117156 | Chen |
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| FUNDED BY |
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| APPLICANT(S) | Colorado State University Research Foundation (Fort Collins, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas Chen (Fort Collins, Colorado) |
| ABSTRACT | Electrochemical sensing devices and methods of using thereof employs a set of one or more sensor-integrated sampling wells or containers that operates with a pressure differential micro-valve to move controlled volume of sampled fluid within a controlled cell-growing environment. The differential micro-valve can be integrated into an instrumented well having one or more sensors to provide a high-throughput smart well plate platform for use in automation operation in diagnostics and drug discovery. |
| FILED | Friday, October 14, 2022 |
| APPL NO | 17/965989 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/40 (20130101) C12M 33/12 (20130101) C12M 41/26 (20130101) C12M 41/34 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/416 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230117172 | Ting et al. |
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| FUNDED BY |
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| APPLICANT(S) | ALLEN INSTITUTE (Seattle, Washington) |
| ASSIGNEE(S) | ALLEN INSTITUTE (Seattle, Washington) |
| INVENTOR(S) | Jonathan Ting (Lake Forest Park, Washington); Bosiljka Tasic (Seattle, Washington); Boaz P. Levi (Seattle, Washington); Tanya Daigle (Lake Forest Park, Washington); Lucas T. Graybuck (Seattle, Washington); Edward Sebastian Lein (Mercer Island, Washington); John K. Mich (Seattle, Washington); Adriana Estela Sedeño Cortés (Seattle, Washington); Hongkui Zeng (Seattle, Washington) |
| ABSTRACT | Artificial expression constructs for selectively modulating gene expression in selected central nervous system cell types are described. The artificial expression constructs can be used to selectively express synthetic genes or modify gene expression in astrocytes, oligodendrocytes, microglia, pericytes, SMC, or endothelial cells. |
| FILED | Friday, March 26, 2021 |
| APPL NO | 17/907385 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/85 (20130101) Original (OR) Class C12N 2830/15 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230117203 | MELLO et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Craig MELLO (Barrington, Rhode Island); Krishna Sumanth GHANTA (Grafton, Massachusetts) |
| ABSTRACT | The disclosure provides novel methods and compositions for gene editing. In particular, the disclosure relates to compositions and methods of making nucleic acid donor templates for highly efficient and precise gene editing. |
| FILED | Monday, August 08, 2022 |
| APPL NO | 17/818226 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/111 (20130101) Original (OR) Class C12N 15/902 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230117680 | Liu et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David R. Liu (Cambridge, Massachusetts); Alexander A. Peterson (Cambridge, Massachusetts); Alvin Hsu (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein are compounds of Formula (I′) or (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating and/or preventing diseases and/or conditions (e.g., neurological (e.g., neurodegenerative) disease (e.g., Alzheimer's disease, multiple sclerosis, Parkinson's disease, Huntington's disease), metabolic disorder (e.g., obesity, diabetes), proliferative disease (e.g., cancers), condition associated with autophagy (e.g., neurodegenerative disease, infection, cancer, condition associated with aging, heart disease), condition associated with aging, condition associated with modulating (e.g., regulating) the mPTP, cardiovascular condition (e.g., ischemia-reperfusion injury), stroke, heart attack, conditions associated with oxidative stress, mitochondrial diseases), or other diseases associated with cyclophilins) in a subject, as well as for reducing oxidative stress. Provided are methods of inhibiting a cyclophilin (e.g., CypB, CypC, CypD, CypE, CypG, CypH, Cyp40, PPWD1, PPIL1, NKTR) in a subject and/or biological sample. |
| FILED | Thursday, December 10, 2020 |
| APPL NO | 17/784075 |
| CURRENT CPC | Peptides C07K 7/56 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230117744 | Baker et al. |
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| FUNDED BY |
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| APPLICANT(S) | LOYOLA UNIVERSITY OF CHICAGO (Chicago, Illinois); THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (District Of Columbia, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Susan Baker (Elmhurst, Illinois); Xufang Deng (Lyons, Illinois); Kelly Milton Lager (Colo, Iowa); Kay Faaberg (Ames, Iowa); Alexandra DeVries (Ames, Iowa) |
| ABSTRACT | The present disclosure provides compositions, for example vaccine compositions comprising live, attenuated coronavirus. The disclosure also provides methods of using coronavirus vaccines, including methods of treating and/or preventing coronavirus infections, and provides methods of preparing coronavirus vaccines. |
| FILED | Tuesday, March 23, 2021 |
| APPL NO | 17/914293 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/215 (20130101) Original (OR) Class A61K 2039/5254 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230117791 | OLSON et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
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| INVENTOR(S) | David E. OLSON (Davis, California); Florence F. Wagner (Davis, California) |
| ABSTRACT | The present invention provides azepino-indoles and other heterocycles and methods of using the compounds for treating brain disorders. |
| FILED | Tuesday, July 12, 2022 |
| APPL NO | 17/862646 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) A61P 25/32 (20180101) Heterocyclic Compounds C07D 487/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230117826 | GRAY et al. |
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| FUNDED BY |
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| APPLICANT(S) | MOLECULAR TARGETING TECHNOLOGIES, INC. (West Chester, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian D. GRAY (Exton, Pennsylvania); Silvia C. FINNEMANN (South Salem, New York); Francesca MAZZONI (Bronx, New York); Koon Y. PAK (Malvern, Pennsylvania) |
| ABSTRACT | Described are compounds, compositions, and methods suitable for diagnosing individuals with eye injuries and/or diseases. The compounds of the present disclosure have fluorescent groups and bis-dipicolylamine groups, which may be substituted or unsubstituted. The fluorescent group and bis-dipicolylamine group are connected by linking groups. The compositions may be formulated and administered as an eye drop. The methods may be used to track and/or label dying cells associated with eye injuries and/or diseases, such as, for example, retinal degenerations including, but not limited to, retinitis pigmentosa, glaucoma, diabetic retinopathy, and age-related macular degeneration. |
| FILED | Wednesday, February 05, 2020 |
| APPL NO | 17/759912 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/005 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) Heterocyclic Compounds C07D 401/14 (20130101) Original (OR) Class C07D 491/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230117830 | Szostak et al. |
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| FUNDED BY |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michal Szostak (Newark, New Jersey); Shicheng Shi (Newark, New Jersey) |
| ABSTRACT | The present disclosure provides, in part, a new class of highly active Pd(II)-NHC complexes bearing anilines as throw-away ligands. These catalysts are well-defined, air- and moisture-stable, and can be easily purified by chromatographic techniques. High activity and generality has been exemplified in the Suzuki-Miyaura cross-coupling by C—N, C—O and C—Cl cleavage. Facile syntheses of these catalysts is also described. |
| FILED | Friday, January 08, 2021 |
| APPL NO | 17/791684 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/181 (20130101) B01J 31/2273 (20130101) Original (OR) Class B01J 2231/4211 (20130101) B01J 2231/4283 (20130101) B01J 2531/824 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 15/006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230117831 | CHOUDHARY et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE BROAD INSTITUTE, INC. (CAMBRIDGE, Massachusetts); THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (BOSTON, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amit CHOUDHARY (Boston, Massachusetts); Sophia LAI (Boston, Massachusetts); Veronika SHOBA (Cambridge, Massachusetts); Praveen KOKKONDA (Boston, Massachusetts); Dhanushka MUNKANATTA GODAGE (Cambridge, Massachusetts); Sachini SIRIWARDENA (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure relates to multifunctional chemical conjugation molecules, which find utility as modifiers of target substrates. The present disclosure includes multifunctional compounds comprising a localizing moiety, a chemical linker moiety, an activator moiety, a first orienting adaptor interconnecting the chemical linker moiety on one end to the activator moiety, and optionally a second orienting adaptor interconnecting the chemical linker molecule on a different end to the localizing moiety. Molecules according to the present invention find use making post-translational modifications to macromolecules that are not the natural substrate of the activator moiety. Diseases or disorders may be treated or prevented with molecules of the present disclosure. |
| FILED | Friday, January 08, 2021 |
| APPL NO | 17/791811 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/551 (20130101) A61K 47/55 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230118114 | Dziubla et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas D. Dziubla (Lexington, Kentucky); Md. Arif Khan (Lexington, Kentucky); Alexander G. Rabchevsky (Nicholasville, Kentucky); Samirkumar P. Patel (Lexington, Kentucky); Jason DeRouchey (Lexington, Kentucky); Patrick G. Sullivan (Nicholasville, Kentucky) |
| ABSTRACT | This disclosure relates to hydrogel compositions with isolated mitochondria suspended therein. The compositions are for providing protection to injured tissue, as well as tissue proximal to a site of injury. The hydrogel provides structural support while the mitochondria are able to prevent or slow cellular death. In some aspects, the compositions include N-acetylcysteine amide and/or acetyl-L-carnitine. |
| FILED | Tuesday, October 04, 2022 |
| APPL NO | 17/959809 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/0085 (20130101) A61K 31/16 (20130101) A61K 31/225 (20130101) A61K 35/34 (20130101) Original (OR) Class A61K 47/36 (20130101) A61K 47/38 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230118199 | Ebbini et al. |
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| FUNDED BY |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Emad S. Ebbini (Edina, Minnesota); Dalong Liu (Sammamish, Washington); Hasan Aldiabat (Minneapolis, Minnesota); Parker O'Brien (Minneapolis, Minnesota) |
| ABSTRACT | A dual-mode ultrasound system provides real-time imaging and therapy delivery using a transducer array. The system may use various imaging modes to provide image data that may be used to select control points within an imaging field of view. The control points along with the image data may be used to solve an optimization problem to achieve desired focusing gains at one or more of the control points. The optimized solution may be used to produce excitation waveforms to generate new image data. The focusing gains may be evaluated and the optimization problem may be iterated until desired focusing gains are achieved. Virtual arrays may be defined and cascaded to provide flexibility in solving the optimization problem. |
| FILED | Wednesday, September 21, 2022 |
| APPL NO | 17/949535 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/54 (20130101) A61B 8/145 (20130101) A61B 8/565 (20130101) A61B 8/0875 (20130101) A61B 8/4488 (20130101) A61B 8/5207 (20130101) A61B 2017/22008 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 7/00 (20130101) Original (OR) Class A61N 7/02 (20130101) A61N 2007/0052 (20130101) A61N 2007/0078 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230118842 | Jafri et al. |
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| FUNDED BY |
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| APPLICANT(S) | GEORGE MASON UNIVERSITY (Fairfax, Virginia) |
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| INVENTOR(S) | Mohsin Saleet Jafri (Potomac, Maryland); Matthew McCoy (Washington, District of Columbia) |
| ABSTRACT | The present disclosure describes methods for determining the functional consequences of mutations. The methods include the use of machine learning to identify and quantify features of all atom molecular dynamics simulations to obtain the disruptive severity of genetic variants on molecular function. |
| FILED | Friday, December 16, 2022 |
| APPL NO | 18/067365 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6827 (20130101) C12Q 1/6883 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/20 (20190201) G16B 10/00 (20190201) G16B 20/00 (20190201) G16B 20/20 (20190201) Original (OR) Class G16B 35/00 (20190201) G16B 40/20 (20190201) G16B 40/30 (20190201) G16B 50/10 (20190201) G16B 50/50 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230118877 | Lau et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Maryland, Baltimore (Baltimore, Maryland); University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christine Lau (Charlottesville, Virginia); Yunge Zhao (Millersville, Maryland); Joel M. Linden (Charlottesville, Virginia); Barbara J. Mann (Charlottesville, Virginia); Preeti Chhabra (Waynesboro, Virginia); Kenneth Lewis Brayman (Charlottesville, Virginia); Sanford Feldman (Charlottesville, Virginia) |
| ABSTRACT | The present invention relates methods of treating cytokine storm syndrome comprising administering to a patient in need thereof a therapeutically effective amount of an adenosine A2A receptor agonist. |
| FILED | Thursday, June 02, 2022 |
| APPL NO | 17/831191 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/53 (20130101) A61K 31/404 (20130101) A61K 31/519 (20130101) A61K 31/7076 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) A61P 37/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230119163 | NAKAI et al. |
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| FUNDED BY |
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| APPLICANT(S) | Oregon Health and Science University (Portland, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hiroyuki NAKAI (Portland, Oregon); Samuel HUANG (Portland, Oregon); Kei ADACHI (Portland, Oregon) |
| ABSTRACT | Disclosed are methods for performing transcription-dependent directed evolution (TRADE) and novel AAV capsids selected using such methods. |
| FILED | Wednesday, August 24, 2022 |
| APPL NO | 17/822111 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/11 (20130101) Original (OR) Class C12N 15/86 (20130101) C12N 2310/11 (20130101) C12N 2320/33 (20130101) C12N 2750/14123 (20130101) C12N 2830/008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230119171 | Theodorescu et al. |
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| FUNDED BY |
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| APPLICANT(S) | CEDARS-SINAI MEDICAL CENTER (Los Angeles, California) |
| ASSIGNEE(S) | CEDARS-SINAI MEDICAL CENTER (Los Angeles, California) |
| INVENTOR(S) | Dan Theodorescu (Los Angeles, California); Sungyong You (Los Angeles, California); Keith Syson Chan (Los Angeles, California) |
| ABSTRACT | The present invention describes methods of detecting biomarkers in tumor tissue, as well as methods of improving responsiveness to or providing survival prognosis for a subject having received or in need of, an immune checkpoint inhibitor in the treatment of cancers such as bladder cancer, lung cancer, leukemia. Discoidin domain receptor (DDR)-driven gene signatures have been identified and validated to stratify patient response to anti-PD-L1 immune checkpoint therapy. |
| FILED | Wednesday, March 31, 2021 |
| APPL NO | 17/914050 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/05 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230119375 | Gordon et al. |
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| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wendy R. Gordon (Minneapolis, Minnesota); Eric Aird (Minneapolis, Minnesota); Klaus Lovendahl (Minneapolis, Minnesota) |
| ABSTRACT | Materials and methods for gene editing using improved targeted endonucleases and endonuclease systems (e.g., Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) endonuclease systems) are provided herein. |
| FILED | Tuesday, July 05, 2022 |
| APPL NO | 17/810691 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/11 (20130101) C12N 15/87 (20130101) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230119547 | HUFF et al. |
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| FUNDED BY |
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| APPLICANT(S) | FGH BIOTECH, INC. (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | JOEL HUFF (Spring Branch, Texas); Montonari Uesugi (Osaka, Japan); John Kincaid (Hayward, California) |
| ABSTRACT | Provided herein are compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds and compositions in treating a condition, disease, or disorder associated with abnormal activation of the SREBP pathway, including metabolic disorders such as obesity, cancer, cardiovascular disease, and nonalcoholic fatty liver disease (NAFLD) wherein the compound is according to Formula (I). |
| FILED | Thursday, September 08, 2022 |
| APPL NO | 17/940640 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/506 (20130101) A61K 31/4439 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/00 (20180101) A61P 9/00 (20180101) A61P 35/00 (20180101) Heterocyclic Compounds C07D 231/12 (20130101) C07D 305/08 (20130101) C07D 307/22 (20130101) C07D 401/04 (20130101) C07D 401/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230119684 | LI et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| INVENTOR(S) | King C. LI (Urbana, Illinois); Gun KIM (Urbana, Illinois); Qiong WU (Urbana, Illinois); Jeffrey S. MOORE (Savoy, Illinois); Yun-Sheng CHEN (Champaign, Illinois) |
| ABSTRACT | Provided herein are compositions and methods for mechanochemical dynamic therapy. |
| FILED | Friday, October 14, 2022 |
| APPL NO | 17/965908 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 31/10 (20130101) A61K 31/327 (20130101) A61K 31/655 (20130101) Original (OR) Class A61K 47/10 (20130101) A61K 47/34 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230120072 | ZHANG et al. |
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| FUNDED BY |
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| APPLICANT(S) | William Marsh Rice University (Houston, Texas) |
| ASSIGNEE(S) | William Marsh Rice University (Houston, Texas) |
| INVENTOR(S) | David ZHANG (Houston, Texas); Ruojia WU (Houston, Texas); Peng DAI (Houston, Texas); Yuxuan CHENG (Houston, Texas); Xiangjiang WANG (Houston, Texas) |
| ABSTRACT | Provided herein are hybrid capture-based methods to extract single-stranded DNA or RNA directly from non-treated biospecimens. The methods allow for the detection and analysis of unexplored short single-stranded DNA (sssDNA, mean length 50 nt) and ultrashort single-stranded DNA (ussDNA, mean length 15 nt) of human origin present in the biospecimen. The methods allow the discovery of unexplored short single-stranded DNA (sssDNA) in isolated red blood cells, which were believed to be deprived of nucleic acids because of the lack of a nucleus in mature red blood cells. The DNA or RNA extracted using the disclosed methods can be used as disease prognostic biomarkers and treatment predictive biomarkers. |
| FILED | Friday, December 18, 2020 |
| APPL NO | 17/787290 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6874 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230120244 | Ma et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter X. Ma (Ann Arbor, Michigan); Xiaojin Zhang (Wuhan, China PRC) |
| ABSTRACT | A hyperbranched polymer includes a hyperbranched, hydrophobic molecular core, respective low molecular weight polyethyleneimine chains attached to at least three branches of the hyperbranched, hydrophobic molecular core, and respective polyethylene glycol chains attached to at least two other branches of the hyperbranched, hydrophobic molecular core. Examples of the hyperbranched polymer may be used to form hyperbranched polyplexes, and may be included in DNA or RNA delivery systems. |
| FILED | Tuesday, December 06, 2022 |
| APPL NO | 18/076030 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/50 (20170801) A61K 47/60 (20170801) A61K 47/593 (20170801) Original (OR) Class A61K 47/6937 (20170801) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) A61L 27/26 (20130101) A61L 27/44 (20130101) A61L 27/52 (20130101) A61L 27/54 (20130101) A61L 27/56 (20130101) A61L 27/58 (20130101) A61L 2300/258 (20130101) A61L 2300/604 (20130101) A61L 2430/02 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 210/02 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/66 (20130101) C08G 73/024 (20130101) C08G 73/0206 (20130101) C08G 81/00 (20130101) C08G 83/00 (20130101) C08G 83/005 (20130101) C08G 2210/00 (20130101) C08G 2230/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2310/14 (20130101) C12N 2310/51 (20130101) C12N 2310/52 (20130101) C12N 2310/141 (20130101) C12N 2310/351 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230120340 | Elisseeff et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jennifer H. Elisseeff (Baltimore, Maryland); Liam Chung (Baltimore, Maryland); Xiaokun Wang (Baltimore, Maryland) |
| ABSTRACT | Provided herein, inter alia, are methods of treating an ocular injury, disease or disorder with use of one or more extracellular matrix materials. |
| FILED | Tuesday, December 20, 2022 |
| APPL NO | 18/068598 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/16 (20130101) Original (OR) Class A61K 9/0048 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/3633 (20130101) A61L 2430/16 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) A61P 37/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230120420 | Ferrari de Andrade et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lucas Ferrari de Andrade (Boston, Massachusetts); Kai W. Wucherpfenning (Brookline, Massachusetts) |
| ABSTRACT | The present invention is based, in part, on the discovery of monoclonal antibodies, and antigen-binding fragments thereof, that specifically bind to MICA/B α3 domain, as well as immunoglobulins, polypeptides, nucleic acids thereof, and methods of using such antibodies for diagnostic, prognostic, and therapeutic purposes. |
| FILED | Friday, June 24, 2022 |
| APPL NO | 17/849415 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4164 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) Peptides C07K 16/2833 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230120566 | Pathak et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Southern Research Institute (Birmingham, Alabama); Oregon Health and Science University (Portland, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ashish Kumar Pathak (Birmingham, Alabama); Corinne E. Augelli-Szafran (Homewood, Alabama); Atefeh Garzan (Hoover, Alabama); Daniel Steblow (Banks, Oregon); Nicole Haese (Beaverton, Oregon) |
| ABSTRACT | The present disclosure is concerned with 2-pyrimidone compounds that are capable of inhibiting a viral infection and methods of treating alphavirus viral infections such as, for example, chikungunya, Eastern equine encephalitis (EEEV), Western equine encephalitis (WEEV), and Venezuelan equine encephalitis using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| FILED | Tuesday, December 13, 2022 |
| APPL NO | 18/080692 |
| CURRENT CPC | Heterocyclic Compounds C07D 213/69 (20130101) C07D 213/70 (20130101) C07D 213/74 (20130101) C07D 403/04 (20130101) Original (OR) Class C07D 491/052 (20130101) C07D 498/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230120677 | GRISWOLD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire); CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karl E. GRISWOLD (Lyme, New Hampshire); Chris BAILEY-KELLOGG (STRAFFORD, Vermont); Yoonjoo CHOI (GYEONGGI-DO, South Korea); Yongliang FANG (JIANGSU, China PRC); Deeptak VERMA (FEASTERVILLE-TREVOSE, Pennsylvania); Susan ESZTERHAS (PLAINFIELD, New Hampshire); Min DONG (WEATOGUE, Connecticut); Shin-Ichiro MIYASHITA (BROOKLINE, Massachusetts) |
| ABSTRACT | Deimmunized botulinum toxin light chain (e.g., botulinum toxin serotype A light chains (BoNT/A-LC)) or fragments thereof are provided. Methods for treating or preventing diseases or disorders comprising administering to a subject a deimmunized botulinum toxin light chain (e.g., BoNT/A-LC) are provided. |
| FILED | Wednesday, January 20, 2021 |
| APPL NO | 17/759045 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/00 (20180101) Peptides C07K 14/33 (20130101) Original (OR) Class C07K 16/00 (20130101) C07K 2317/52 (20130101) C07K 2317/55 (20130101) C07K 2317/622 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/70 (20130101) C12N 15/79 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230121031 | Izgu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | Enver Izgu (Piscataway, New Jersey); Tushar Aggarwal (Piscataway, New Jersey) |
| ABSTRACT | In one aspect, the present disclosure relates to a masked fluorogenic compound comprising a small molecule protecting group that can be cleaved following a reaction with a biomarker. In some embodiments, cleavage of the small molecule protecting group provides a fluorogenic ligand that binds to an aptamer, leading to fluorescence emission. In another aspect, the present disclosure relates to a method of detecting a disease or a disorder in a subject and/or in a biological sample from the subject. |
| FILED | Tuesday, August 30, 2022 |
| APPL NO | 17/898995 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/55 (20170801) A61K 47/549 (20170801) A61K 49/0021 (20130101) Original (OR) Class A61K 49/0052 (20130101) A61K 49/0056 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/115 (20130101) C12N 2310/16 (20130101) C12N 2310/351 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 33/54353 (20130101) G01N 33/54386 (20130101) G01N 2021/6439 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230121081 | Parikh |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Houston System (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pranav J. Parikh (Richmond, Texas) |
| ABSTRACT | A hand function testing device includes a base having a number of rigid wires protruding from a surface thereof, each rigid wire having a stationary bead affixed at a predetermined position along the rigid wire, a moving bead movably mounted on the rigid wire and movable along a working region of the rigid wire defined between a base-end of the rigid wire and the stationary bead, the moving bead being mounted on the rigid wire via reception of the rigid wire through a lumen in the moving bead, and at least one force sensing element for measuring a force input to the moving bead. A method of testing hand function includes using the hand function testing device to measure a force input to a moving bead as the moving bead is moved within a working region on the rigid wire. |
| FILED | Monday, October 10, 2022 |
| APPL NO | 17/962597 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/1121 (20130101) A61B 5/1125 (20130101) Original (OR) Class A61B 2562/0252 (20130101) Toys, e.g Tops, Dolls, Hoops or Building Blocks A63H 33/00 (20130101) Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230121232 | Sharp et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Phillip A. Sharp (Newton, Massachusetts); Dig Mahat (Somerville, Massachusetts) |
| ABSTRACT | The present disclosure relates to a method of sequencing nascent RNA in a cell. In some embodiments, the nascent RNA is conjugated to DNA using copper-catalyzed azide-alkyne cycloaddition (CuAAC). Methods of the present disclosure can be used to generate genomic libraries of a cell and measure gene expression and enhancer and/or super-enhancer activity. |
| FILED | Wednesday, November 02, 2022 |
| APPL NO | 17/979195 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/6855 (20130101) C12Q 1/6869 (20130101) Original (OR) Class C12Q 2563/149 (20130101) C12Q 2563/185 (20130101) C12Q 2600/166 (20130101) Enzymes C12Y 207/01078 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230121352 | Reiserer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ronald S. Reiserer (Nashville, Tennessee); Gregory B. Gerken (Nashville, Tennessee); David K. Schaffer (Nashville, Tennessee); John P. Wikswo (Brentwood, Tennessee) |
| ABSTRACT | A fluidic cartridge comprises a fluidic disk having a plurality of alignment openings; a fluidic chip comprising a body, one or more channels formed in the body in fluidic communications with input ports and output ports for transferring one or more fluids between the input ports and the output ports, and a plurality of protrusions formed on the body and received in the alignment openings of the fluidic disk for aligning the fluidic chip to the fluidic disk; an actuator operably engaging with the one or more channels for selectively and individually transferring the one or more fluids through the one or more channels from at least one of the input ports to at least one of the output ports at desired flow rates; and a tube member defining a cylindrical housing for accommodating the fluidic disk, the fluidic chip and the actuator therein. |
| FILED | Wednesday, November 09, 2022 |
| APPL NO | 17/984151 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/08 (20130101) C12M 23/10 (20130101) C12M 23/12 (20130101) C12M 23/16 (20130101) C12M 23/50 (20130101) C12M 23/58 (20130101) C12M 27/02 (20130101) C12M 27/12 (20130101) C12M 29/10 (20130101) Original (OR) Class C12M 35/02 (20130101) C12M 35/04 (20130101) C12M 41/48 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230121406 | MORELLO et al. |
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| FUNDED BY |
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| APPLICANT(S) | Veritium Research LLC (Fort Lee, New Jersey) |
| ASSIGNEE(S) | Veritium Research LLC (Fort Lee, New Jersey) |
| INVENTOR(S) | Gino MORELLO (Fort Lee, New Jersey); Steven PRINA (Fort Lee, New Jersey) |
| ABSTRACT | A magnetically levitated motor includes a stator, a rotor configured to rotate relative to the stator, and a passive radial magnetic bearing configured to support the rotor relative to the stator in a radial direction. An active longitudinal magnetic bearing is configured to selectively position the rotor relative to the stator in an axial direction. |
| FILED | Friday, April 23, 2021 |
| APPL NO | 17/921029 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 60/38 (20210101) A61M 60/117 (20210101) A61M 60/178 (20210101) A61M 60/226 (20210101) A61M 60/419 (20210101) A61M 60/538 (20210101) A61M 60/822 (20210101) Original (OR) Class Shafts; Flexible Shafts; Elements or Crankshaft Mechanisms; Rotary Bodies Other Than Gearing Elements; Bearings F16C 32/0478 (20130101) F16C 2316/18 (20130101) Dynamo-electric Machines H02K 7/09 (20130101) H02K 11/215 (20160101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230121411 | Sarrafzadeh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Majid Sarrafzadeh (Los Angeles, California); Myung-Kyung Suh (Los Angeles, California) |
| ABSTRACT | Congestive heart failure (CHF) is a leading cause of death in the United States. WANDA is a wireless health project that leverages sensor technology and wireless communication to monitor the health status of patients with CHF. The first pilot study of WANDA showed the system’s effectiveness for patients with CHF. However, WANDA experienced a considerable amount of missing data due to system misuse, nonuse, and failure. Missing data is highly undesirable as automated alarms may fail to notify healthcare professionals of potentially dangerous patient conditions. Embodiments of the present disclosure may utilize machine learning techniques including projection adjustment by contribution estimation regression (PACE), Bayesian methods, and voting feature interval (VFI) algorithms to predict both non-binomial and binomial data. The experimental results show that the aforementioned algorithms are superior to other methods with high accuracy and recall. |
| FILED | Tuesday, September 20, 2022 |
| APPL NO | 17/949076 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/7264 (20130101) A61B 5/7267 (20130101) Computer Systems Based on Specific Computational Models G06N 7/01 (20230101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) Original (OR) Class G16H 40/67 (20180101) G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230121804 | Dosenbach et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri); Oregon Health and Science University (Portland, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nico Dosenbach (St. Louis, Missouri); Jonathan Koller (St. Louis, Missouri); Andrew Van (St. Louis, Missouri); Abraham Snyder (St. Louis, Missouri); Amy Mirro (St. Louis, Missouri); Damien Fair (Portland, Oregon); Eric Earl (Portland, Oregon); Rachel Klein (Portland, Oregon); Oscar Miranda Dominguez (Tigard, Oregon); Anders Perrone (Portland, Oregon) |
| ABSTRACT | Methods, computer-readable storage devices, and systems are described for reducing movement of a patient undergoing a magnetic resonance imaging (MRI) scan by aligning MRI data, the method implemented on a Framewise Integrated Real-time MRI Monitoring (“FIRMM”) computing device including at least one processor in communication with at least one memory device. Aspects of the method comprise receiving a data frame from the MRI system, aligning the received data frame to a preceding data frame, calculating motion of a body part between the received data frame and the preceding data frame, calculating total frame displacement, and excluding data frames with a cutoff above a pre-identified threshold of the total frame displacement. |
| FILED | Friday, December 02, 2022 |
| APPL NO | 18/061254 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/0041 (20130101) G01R 33/4831 (20130101) G01R 33/5608 (20130101) G01R 33/56509 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230121926 | Gurtner et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| INVENTOR(S) | Geoffrey C. Gurtner (Stanford, California); Kellen Chen (Stanford, California); Sun Hyung Kwon (Stanford, California); Dominic Henn (Stanford, California) |
| ABSTRACT | Methods are described herein for facilitating tissue regeneration in humans and other large organisms, and kits therefor. Application of an inhibitor of focal adhesion kinase (FAK) to injured tissue may reduce fibrosis and/or scarring during the wound healing process. Patient care for a large number of fibrotic diseases which affect organ function may be ameliorated by such treatment. Kits for application of the FAK inhibitor may include a hydrogel formulation encapsulating the FAK inhibitor. |
| FILED | Monday, January 25, 2021 |
| APPL NO | 17/914134 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/24 (20130101) A61L 27/52 (20130101) A61L 27/54 (20130101) Original (OR) Class A61L 27/56 (20130101) A61L 2300/412 (20130101) A61L 2300/602 (20130101) A61L 2430/18 (20130101) A61L 2430/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230122007 | Zheng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, As Represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhi-Ming Zheng (Rockville, Maryland); Junfen Xu (Frederick, Maryland); Jun Zhu (Potomac, Maryland); Yanqin Yang (Bethesda, Maryland); Xiaohong Wang (Germantown, Maryland) |
| ABSTRACT | Described herein are biomarkers for HPV-associated pre-cancers and cancers such as cervical cancer and cervical intraepithelial neoplasia. The RNA binding protein (RBP) and long-noncoding RNA (lnc-RNA) biomarkers can be detected and used to diagnose HPV-associated pre-cancers and cancers. In addition, early diagnosis of HPV-associated pre-cancers and cancers can facilitate therapeutic intervention in patients, particularly in the pre-cancer stage which can delay or prevent progression to cancer. |
| FILED | Monday, August 01, 2022 |
| APPL NO | 17/816656 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/112 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230122024 | De Brabander et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Jef De Brabander (Dallas, Texas); Daniel Rosenbaum (Dallas, Texas); Qiren Liang (Dallas, Texas); Wentian Wang (Dallas, Texas) |
| ABSTRACT | Methods and compositions for agonizing a type-2 orexin receptor (OX2R) in a cell determined to be in need thereof, including the general method of (a) administering to a subject a cyclic guanidinyl OX2R agonist and (b) detecting a resultant enhanced wakefulness or increased resistance to diet-induced accumulation of body fat, or abbreviated recovery from general anesthesia or jet lag. |
| FILED | Friday, October 21, 2022 |
| APPL NO | 17/971547 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/422 (20130101) A61K 31/423 (20130101) A61K 31/427 (20130101) A61K 31/428 (20130101) A61K 31/501 (20130101) A61K 31/506 (20130101) A61K 31/4184 (20130101) A61K 31/4192 (20130101) A61K 31/4355 (20130101) A61K 31/4439 (20130101) A61K 31/4709 (20130101) Heterocyclic Compounds C07D 235/30 (20130101) C07D 401/06 (20130101) C07D 401/12 (20130101) C07D 403/12 (20130101) C07D 405/12 (20130101) C07D 409/06 (20130101) C07D 413/06 (20130101) C07D 413/12 (20130101) C07D 417/12 (20130101) C07D 471/04 (20130101) C07D 491/107 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230122226 | Gendelman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Howard Gendelman (Omaha, Nebraska); Jonathan Herskovitz (Omaha, Nebraska); Mahmudul Hasan (Omaha, Nebraska) |
| ABSTRACT | Nucleic acids for use in CRISPR systems for treating HIV infections are disclosed. Pharmaceutical compositions incorporating the nucleic acids are disclosed as are methods of treating HIV using the nucleic acids. |
| FILED | Friday, March 05, 2021 |
| APPL NO | 17/905407 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/86 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230122364 | CROWE, Jr. et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James E. CROWE, Jr. (Nashville, Tennessee); Seth ZOST (Nashville, Tennessee); Robert CARNAHAN (Nashville, Tennessee); Pavlo GILCHUK (Nashville, Tennessee) |
| ABSTRACT | The present disclosure is directed to antibodies binding to and neutralizing tire coronavirus designated SARS-CoV-2 and methods for use thereof. |
| FILED | Friday, March 26, 2021 |
| APPL NO | 17/907320 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/545 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/10 (20130101) Original (OR) Class C07K 2317/52 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) G01N 2333/165 (20130101) G01N 2469/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230122594 | Reiserer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ronald S. Reiserer (Nashville, Tennessee); David K. Schaffer (Nashville, Tennessee); Philip C. Samson (Nashville, Tennessee); Dmitry A. Markov (Nashville, Tennessee); Michael Geuy (Nashville, Tennessee); Lisa J. McCawley (Nashville, Tennessee); John P. Wikswo (Brentwood, Tennessee) |
| ABSTRACT | Microfluidic systems, pumps, valves and applications of the same are provided. The microfluidic system may be a pump or a valve having a fluidic chip and an actuator controlling the opening and closing of the fluidic channel in the fluidic chip. The actuator may be disposed to tilt from the fluidic chip, forming a tilted-rotor peristaltic pump. Alternatively, the actuator may be a rolling ball actuator, and different fluidic chips may be used in different applications. For example, the fluidic chip may be a spiral pump chip having spiral channels, a rotary peristaltic pump chip having multiple output channels, or a multi-port valve chip having one port interconnected with multiple different ports. An analytical valve chip may switchably interconnect bioreactor and rinse/calibration input channels to sensor and waste output channels. The actuator of a random-access valve can move from one valve position to another without opening or closing intermediate ones. |
| FILED | Tuesday, December 20, 2022 |
| APPL NO | 18/084634 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502738 (20130101) Original (OR) Class B01L 2300/123 (20130101) B01L 2300/0627 (20130101) B01L 2400/0644 (20130101) Positive-displacement Machines for Liquids; Pumps F04B 43/1261 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230122797 | Yang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | The University of Chicago (Chicago, Illinois) |
| INVENTOR(S) | Qiwei Yang (Bolingbrook, Illinois); Ayman Al-Hendy (Hinsdale, Illinois) |
| ABSTRACT | In aspects, the present disclosure provides a method of treating or preventing a uterine fibroid in a female mammal, the method comprising, consisting essentially of, or consisting of administering to the female mammal an effective amount of an inhibitor of bromodomain (BRD) protein. |
| FILED | Tuesday, October 18, 2022 |
| APPL NO | 17/968403 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/437 (20130101) A61K 31/551 (20130101) Original (OR) Class A61K 31/4365 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 15/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230122801 | Bernstein et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for the State University of New York (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Audrey Bernstein (Fayetteville, New York); Alexey Wolfson (Westborough, Massachusetts); Sean McCauley (Rutland, Massachusetts) |
| ABSTRACT | The present disclosure provides compositions and methods for using self-deliverable siRNA (sdRNAi) directed against USP-10 for the treatment of various medical conditions, including skin scarring due to trauma wounds and surgery, corneal and retina scarring due to injury and surgery, internal organ scarring due to injury and surgery, heart tissue scarring due to heart attack and surgery, and lung, liver, and kidney fibrosis due to inflammation and injury. In embodiments, compositions including self-deliverable siRNA (sdRNAi) directed against USP-10 are suitable for use in pharmaceutical formulations and treatments resulting in significant less scar formation, and include synthetic nucleic acids such as sense and antisense oligonucleotides. |
| FILED | Sunday, February 28, 2021 |
| APPL NO | 17/907826 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/315 (20130101) C12N 2310/3515 (20130101) Enzymes C12Y 304/19012 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230122855 | Edinger et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); The Université de Montréal (Montreal, Canada) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California); The Université de Montréal (Montreal, Canada) |
| INVENTOR(S) | Aimee L. Edinger (Irvine, California); Stephen Hanessian (Irvine, California) |
| ABSTRACT | Small molecules comprised of azacyclic constrained sphingolipid-like compounds and methods of their synthesis are provided. Formulations and medicaments are also provided that are directed to the treatment of disease, such as, for example, neoplasms, cancers, and other diseases. Therapeutics are also provided containing a therapeutically effective dose of one or more small molecule compounds, present either as pharmaceutically effective salt or in pure form, including, but not limited to, formulations for oral, intravenous, or intramuscular administration. |
| FILED | Thursday, October 13, 2022 |
| APPL NO | 18/046471 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/40 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 207/06 (20130101) C07D 207/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230122977 | Jabbari |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of South Carolina (Columbia, South Carolina) |
| ASSIGNEE(S) | University of South Carolina (Columbia, South Carolina) |
| INVENTOR(S) | Esmaiel Jabbari (Bethesda, Maryland) |
| ABSTRACT | Described herein are regenerative approaches with tunable cell-cell and cell-matrix interactions to enhance the ability to regenerate multiple zones within a construct with each zone possessing a unique, optimum, level of cell-cell and cell-matrix interaction. |
| FILED | Thursday, March 10, 2022 |
| APPL NO | 17/691262 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/51 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/38 (20130101) A61L 27/54 (20130101) A61L 27/56 (20130101) A61L 27/227 (20130101) A61L 27/3612 (20130101) Original (OR) Class A61L 2101/46 (20200801) A61L 2400/12 (20130101) A61L 2400/18 (20130101) A61L 2430/10 (20130101) A61L 2430/20 (20130101) A61L 2430/26 (20130101) A61L 2430/32 (20130101) A61L 2430/34 (20130101) A61L 2430/40 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0607 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230123017 | Skala et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Melissa C. Skala (Middleton, Wisconsin); Kaivalya Molugu (Madison, Wisconsin); Krishanu Saha (Madison, Wisconsin) |
| ABSTRACT | Systems and methods for identifying a current reprogramming status and for predicting a future reprogramming status for reprogramming intermediate cells (i.e., somatic cells undergoing reprogramming) are provided. Label-free autofluorescence measurements are combined with machine learning techniques to provide highly accurate identification of current reprogramming status and prediction of future reprogramming status. The identification of current reprogramming status utilizes metabolic endpoints from the autofluorescence data set. The prediction of future reprogramming status utilizes a pseudotime line constructed from autofluorescence data of reprogramming intermediate cells having a known reprogramming status. |
| FILED | Tuesday, October 18, 2022 |
| APPL NO | 17/968027 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1055 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6486 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) G16B 40/10 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230123171 | Parekkadan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | Biju Parekkadan (Atlantic Highlands, New Jersey); Lorenzo Tosi (Franklin Park, New Jersey) |
| ABSTRACT | Methods of generating mature ssDNA LASSO probes using DNA recombinase mediated assembly are provided. Also provided are mature ssDNA LASSO probes made by the methods, methods of their use, and kits including such. |
| FILED | Friday, October 14, 2022 |
| APPL NO | 18/046896 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/102 (20130101) Original (OR) Class C12N 15/907 (20130101) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230123187 | Herz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (AUSTIN, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joachim Herz (Austin, Texas); Yinyuan Ding (Austin, Texas); Xunde Xian (Austin, Texas); Linzhang Huang (Austin, Texas); Chieko Mineo (Austin, Texas); Philip Shaul (Austin, Texas); Laurent Calvier (Austin, Texas) |
| ABSTRACT | The present invention provides methods and compositions for treating atherosclerosis in a subject comprising the use of therapeutic compounds to reduce Reelin in the circulation of the subject, thereby reducing the adhesion of leukocytes to the vascular wall. The invention also provides methods and compositions for reducing leukocyte adhesion to the vascular wall in a subject. |
| FILED | Thursday, September 22, 2022 |
| APPL NO | 17/934426 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0276 (20130101) A01K 2217/206 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) A61K 38/00 (20130101) A61K 45/06 (20130101) Peptides C07K 16/18 (20130101) C07K 16/40 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) C12N 2310/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230123265 | Yang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | The University of Chicago (Chicago, Illinois) |
| INVENTOR(S) | Qiwei Yang (Bolingbrook, Illinois); Ayman Al-Hendy (Hinsdale, Illinois) |
| ABSTRACT | In aspects, the present disclosure provides a method of treating or preventing a uterine fibroid in a female mammal, the method comprising, consisting essentially of, or consisting of administering to the female mammal an effective amount of an agent that modulates an N6-methyladenosine (m6A) regulator. |
| FILED | Tuesday, October 18, 2022 |
| APPL NO | 17/968386 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) Original (OR) Class A61K 35/768 (20130101) A61K 38/44 (20130101) A61K 38/45 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) C12N 2310/531 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230123400 | Beaumont |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Jacques Beaumont (Liverpool, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jacques Beaumont (Liverpool, New York) |
| ABSTRACT | A method for time constant estimation includes generating a bound for a R=1/ |
| FILED | Monday, November 28, 2022 |
| APPL NO | 17/994575 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/002 (20130101) G01N 33/48728 (20130101) Original (OR) Class Electric Digital Data Processing G06F 17/13 (20130101) Computer Systems Based on Specific Computational Models G06N 7/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230123513 | Jiang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The Broad Institute, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kaiyi Jiang (Cambridge, Massachusetts); Rohan Neil Krajeski (Boston, Massachusetts); Omar Osama Abudayyeh (Cambridge, Massachusetts); Jonathan S. Gootenberg (Cambridge, Massachusetts); Yifan Zhang (Cambridge, Massachusetts); Fei Chen (Cambridge, Massachusetts); Xi Chen (Roxbury Crossing, Massachusetts); Jeremy G. Koob (Somerville, Massachusetts) |
| ABSTRACT | RNA editing tools for use in systems designed to measure RNA in vivo and manipulate specific cell types are disclosed herein. An RNA sensor system comprising a) a single-stranded RNA (ssRNA) sensor comprising a stop codon and a payload; optionally wherein the ssRNA sensor further comprises a normalizing gene; and b) an adenosine deaminase acting on RNA (ADAR) deaminase; wherein the sensor is capable of binding to a ssRNA target to form a double-stranded RNA (dsRNA) duplex that becomes a substrate for the ADAR deaminase; wherein the substrate comprises a mispairing within the stop codon; and wherein the mispairing is editable by the ADAR deaminase, which editing can effectively remove the stop codon so as to enable translation and expression of the payload. A method of quantifying ribonucleic acid (RNA) levels using the RNA sensor system is also disclosed. |
| FILED | Tuesday, June 14, 2022 |
| APPL NO | 17/806879 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/50 (20130101) C12N 9/78 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 15/1055 (20130101) C12N 2310/14 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6897 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230123669 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); The Brigham and Woman's Hospital, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | David R. Liu (Cambridge, Massachusetts); Mandana Arbab (Cambridge, Massachusetts); Max Walt Shen (Cambridge, Massachusetts); Christopher Cassa (Boston, Massachusetts) |
| ABSTRACT | The present disclosure provides a novel machine learning model capable of assisting those of ordinary skill in the art to conduct base editing by, inter alia, facilitating the selection of an appropriate guide RNA and base editor combination which are capable of conducting base editing at a certain level of efficiency and specificity on a given input target DNA sequence desired to be edited to produce an outcome genotype of interest. The disclosure also provides base editors (e.g., ABEs and CBEs), napDNAbps, cytidine deaminases, adenosine deaminases, nucleic acid sequences encoding base editors and components thereof, vectors, and cells. In addition, the disclosure provides methods of making biological or experimental training and/or validation data for training and/or validating the machine learning computational models, as well as, vectors, libraries, and nucleic acid sequences for use in obtaining said experimental training and/or validation data. |
| FILED | Friday, February 05, 2021 |
| APPL NO | 17/797697 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/50 (20190201) G16B 40/00 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230123729 | BROWNSTEIN |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Azevan Pharmaceuticals, Inc. (Bethlehem, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael J. BROWNSTEIN (Rockville, Maryland) |
| ABSTRACT | Compounds, and compositions, methods, and uses thereof, are described herein for treating neurodegenerative diseases and disorders. In particular, vasopressin receptor modulators, and compositions, methods and uses thereof, are described herein for treating neuropsychiatric aspects of neurodegenerative diseases such as Huntington's Disease, Parkinson's Disease, and Alzheimer's Disease. |
| FILED | Friday, April 29, 2022 |
| APPL NO | 17/732631 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/397 (20130101) A61K 31/422 (20130101) A61K 31/496 (20130101) A61K 31/4025 (20130101) A61K 31/4178 (20130101) A61K 31/4453 (20130101) A61K 45/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Heterocyclic Compounds C07D 413/04 (20130101) Original (OR) Class C07D 413/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230123746 | Im et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hyungsoon Im (Peabody, Massachusetts); Ralph Weissleder (Peabody, Massachusetts) |
| ABSTRACT | Systems, methods, and devices are described herein for detecting and/or monitoring target extracellular vesicles (“EVs”), e.g., to detect and/or monitor cancer treatment, such as breast cancer, in a subject. The methods can include obtaining a nano-plasmonic array including nanostructures configured to amplify one or more specific wavelengths of electromagnetic radiation, flowing a liquid sample over the nano-plasmonic array, optionally labeling target EVs captured on the nano-plasmonic array with one or more reporter groups, projecting electromagnetic radiation onto the labeled target EVs captured on the nano-plasmonic array, and capturing an image of the target EVs by receiving electromagnetic radiation emitted, scattered, or reflected by the labeled target EVs or by reporter groups on the labeled target EVs. |
| FILED | Friday, October 14, 2022 |
| APPL NO | 17/966621 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/0227 (20130101) G01N 15/1434 (20130101) G01N 15/1463 (20130101) G01N 21/554 (20130101) Original (OR) Class G01N 21/648 (20130101) G01N 21/6458 (20130101) G01N 33/5076 (20130101) G01N 2015/0038 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230123747 | Chiosis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Memorial Sloan-Kettering Cancer Center (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gabriela Chiosis (New York, New York); Pengrong Yan (New York, New York); Pallav Patel (Fresh Meadows, New York); Hardik J. Patel (Kew Gardens, New York); Tony Taldone (Forest Hills, New York); Chenghua Yang (Shanghai, China PRC); Weilin Sun (Princeton, New Jersey); Stefan O. Ochiana (Chevy Chase, Maryland) |
| ABSTRACT | The disclosure relates to novel selective Grp94 inhibitors, compositions comprising an effective amount of such compounds, and methods to treat or prevent a condition, such as cancer, comprising administering to an animal in need thereof an effective amount of such compounds. |
| FILED | Friday, January 21, 2022 |
| APPL NO | 17/581010 |
| CURRENT CPC | Heterocyclic Compounds C07D 473/34 (20130101) Original (OR) Class C07D 519/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5011 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 35/00 (20190201) Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 20/60 (20190201) G16C 20/64 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230123785 | SEYEDSAYAMDOST et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| INVENTOR(S) | Mohammad R. SEYEDSAYAMDOST (Princeton, New Jersey); Fei XU (Princeton, New Jersey); Yihan WU (Princeton, New Jersey); Leah BUSHIN (Princeton, New Jersey); Katherine Davis (Princeton, New Jersey) |
| ABSTRACT | Microorganisms are prolific producers of natural products, a group of molecules that make up the majority of drugs approved by the FDA in the past 35 years. After decades of mining, the low-hanging fruit has been picked and so discovery of drug-like molecules from microorganisms has come to a near-halt. The reason for this lack of productivity is that most biosynthetic pathways that give rise to natural products are not active under typical laboratory growth conditions. These so-called ‘cryptic’ or ‘silent’ pathways are a major source of new bioactive molecules and methods that reliably activate them could have a profound impact on drug discovery. Disclosed herein is a rapid genetics-free method for eliciting and detecting cryptic metabolites using an imaging mass spectrometry-based approach. An organism of choice is challenged with elicitors from a small molecule library. The molecules elicited are then imaged by mass spec, which allows for rapid identification of cryptic metabolites. These are then isolated and characterized. Employing the disclosed approach activated production of cryptic glycopeptides from an actinomycete bacterium. The molecules that result, the keratinimicins and keratinicyclins, are metabolites with important structural features. At least two of these, keratinimicins B and C, are highly bioactive against several pathogenic strains. This approach will allow for rapid activation and identification of cryptic metabolites from diverse microorganisms in the future. |
| FILED | Thursday, December 01, 2022 |
| APPL NO | 18/072800 |
| CURRENT CPC | Peptides C07K 9/008 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 1/38 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/56 (20130101) C12P 21/005 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/18 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6848 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230123800 | MAGGI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GALAXY DIAGNOSTICS, INC. (RESEARCH TRIANGLE PARK, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | RICARDO G MAGGI (Apex, North Carolina); JENNIFER C. MILLER (CARY, North Carolina) |
| ABSTRACT | Provided herein are compositions, methods, and kits for detecting the presence of and/or identifying fastidious microorganisms, such as Bartonella spp., Borrelia spp., Anaplasma spp., Ehrlichia spp., Babesia/Theileria spp., Rickettsia spp., and/or Mycoplasma spp., in a sample. The compositions, methods and kits of the inventive concept include use of droplet digital PCR (ddPCR) assays for the detection and quantitation of the fastidious microorganisms. |
| FILED | Thursday, October 13, 2022 |
| APPL NO | 18/046342 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/689 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230124070 | Kurtz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | David M. Kurtz (San Carlos, California); Maximilian Diehn (San Carlos, California); Arash Ash Alizadeh (San Mateo, California) |
| ABSTRACT | Processes and materials to detect cancer from a biopsy are described. In some cases, cell-free nucleic acids can be sequenced, and the sequencing result can be utilized to detect sequences derived from a neoplasm. Detection of somatic variants occurring in phase can indicate the presence of cancer in a diagnostic scan and a clinical intervention can be performed. |
| FILED | Thursday, November 17, 2022 |
| APPL NO | 18/056656 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1089 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) C12Q 1/6874 (20130101) C12Q 1/6886 (20130101) Original (OR) Class Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/10 (20190201) G16B 20/20 (20190201) G16B 30/00 (20190201) G16B 30/10 (20190201) G16B 35/20 (20190201) G16B 40/00 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/40 (20180101) G16H 10/60 (20180101) G16H 20/10 (20180101) G16H 50/20 (20180101) G16H 50/30 (20180101) G16H 50/70 (20180101) G16H 70/60 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230124253 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jin Chen (San Francisco, California); Luke Gilbert (San Francisco, California); James Nunez (San Francisco, California); Jonathan Weissman (San Francisco, California) |
| ABSTRACT | Provided herein are, inter alia, compositions and methods for manipulation of genomes of living organisms. |
| FILED | Friday, July 29, 2022 |
| APPL NO | 17/816369 |
| CURRENT CPC | Peptides C07K 14/4702 (20130101) C07K 2319/09 (20130101) C07K 2319/33 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/20 (20130101) C12N 9/1007 (20130101) C12N 15/62 (20130101) Original (OR) Class C12N 15/113 (20130101) Enzymes C12Y 201/01072 (20130101) C12Y 301/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230124268 | DRIVER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF INDIANA UNIVERSITY (Indianapolis, Indiana); The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tom G. DRIVER (Chicago, Illinois); Roberto F. MACHADO (Carmel, Indiana); Najing SU (Newark, Delaware); Xinyu GUAN (Chicago, Illinois); Wrickban MAZUMDAR (Chicago, Illinois); Kira RATIA (Chicago, Illinois); Jason Ralph HICKOK (Chicago, Illinois); Angelia Denise LOCKETT (Indianapolis, Indiana) |
| ABSTRACT | Disclosed herein are compounds that can act as inhibitors of nicotinamide phosphoribosyltransferase (“NAMPT”), and methods for their use in treating or preventing diseases, such as pulmonary arterial hypertension (“PAH”). The compounds described herein can include compounds of Formula (II) and pharmaceutically acceptable salts thereof: wherein the substituents are as described. |
| FILED | Wednesday, November 16, 2022 |
| APPL NO | 18/056089 |
| CURRENT CPC | Heterocyclic Compounds C07D 401/12 (20130101) C07D 491/056 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/0816 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230124274 | Weiss et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Ron Weiss (Newton, Massachusetts); Giulio Alighieri (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure, at least in part, relates to a miRNA based logic gate that comprises an engineered RNA carrier that comprises an nuclear export signal, a target site for a first miRNA and a pre-miRNA sequence for a second miRNA. Also provided by the disclosure are recombinant viruses (e.g., recombinant adeno-associated viruses (rAAV)) for delivery of the miRNA based logic gates. |
| FILED | Tuesday, November 01, 2022 |
| APPL NO | 17/978490 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/141 (20130101) C12N 2320/53 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230124429 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John W. Chen (Newton, Massachusetts); Cuihua Wang (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein are compounds useful as imaging agents. Exemplary compounds provided herein are useful as myeloperoxidase imaging agents using magnetic resonance or nuclear imaging techniques. Methods for preparing the compounds provided herein and diagnostic methods using the compounds are also provided. |
| FILED | Wednesday, December 16, 2020 |
| APPL NO | 17/785760 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/003 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230124492 | Pagba et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Regents of the University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cynthia V. Pagba (Houston, Texas); Alemayehu Gorfe Abebe (Houston, Texas); Scott R. Gilbertson (Houston, Texas); Kasuni Dilsha (Houston, Texas) |
| ABSTRACT | In one aspect, the disclosure relates to compounds useful as inhibitors of mutant KRAS proteins, methods of making the same, pharmaceutical compositions comprising the same, and methods of treating cancers associated with mutated forms of KRAS using the same. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure. |
| FILED | Thursday, December 10, 2020 |
| APPL NO | 17/784078 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 487/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230124641 | OBIKA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Osaka University (Osaka, Japan); Japan as Represented by Director General of National Institute of health Sciences (Kawasaki-sjo, Kanagawa, Japan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Satoshi OBIKA (Osaka, Japan); Takao YAMAGUCHI (Osaka, Japan); Yota SAKURAI (Osaka, Japan); Chika YAMAMOTO (Osaka, Japan); Kei SUGITA (Osaka, Japan); Takao INOUE (Kawasaki-shi, Kanagawa, Japan); Tokuyuki YOSHIDA (Kawasaki-shi, Kanagawa, Japan) |
| ABSTRACT | A cross-linked nucleoside of the present invention is a compound represented by the formula (I) below. The cross-linked nucleoside of the present invention is usable as a substitute for a phosphorothioate-modified nucleic acid, which has a risk of, for example, accumulation in a specific organ. The cross-linked nucleoside also has excellent industrial productivity. |
| FILED | Wednesday, February 17, 2021 |
| APPL NO | 17/800339 |
| CURRENT CPC | Heterocyclic Compounds C07D 239/10 (20130101) C07D 493/08 (20130101) Original (OR) Class Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230124955 | Dong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Yizhou Dong (Dublin, Ohio); Kevin Thomas Love (Boston, Massachusetts); Robert S. Langer (Newton, Massachusetts); Daniel Griffith Anderson (Framingham, Massachusetts); Delai Chen (Cambridge, Massachusetts); Yi Chen (Cambridge, Massachusetts); Arturo Jose Vegas (Belmont, Massachusetts); Akinleye C. Alabi (Ithaca, New York); Yunlong Zhang (Cambridge, Massachusetts) |
| ABSTRACT | Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R′, R1, R2, R3, R4, R5, R8, Z, W, Y, and Z are as defined herein. |
| FILED | Tuesday, August 23, 2022 |
| APPL NO | 17/893918 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/711 (20130101) A61K 31/7105 (20130101) Original (OR) Class A61K 47/22 (20130101) A61K 2121/00 (20130101) Acyclic or Carbocyclic Compounds C07C 229/12 (20130101) C07C 229/22 (20130101) C07C 229/24 (20130101) C07C 229/26 (20130101) C07C 229/36 (20130101) C07C 237/08 (20130101) C07C 237/12 (20130101) C07C 271/22 (20130101) C07C 279/14 (20130101) C07C 323/58 (20130101) Heterocyclic Compounds C07D 207/16 (20130101) C07D 209/20 (20130101) C07D 209/24 (20130101) C07D 233/64 (20130101) C07D 241/08 (20130101) C07D 265/32 (20130101) C07D 403/06 (20130101) C07D 413/06 (20130101) C07D 487/04 (20130101) C07D 487/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/87 (20130101) C12N 15/88 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/025 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/15 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230124977 | Georgiev et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ivelin Stefanov Georgiev (Nashville, Tennessee); Kelsey A. Pilewski (Nashville, Tennessee) |
| ABSTRACT | The present disclosure relates to broadly neutralizing antibodies and uses thereof for treating a pathogen infection or a co-infection of multiple pathogens. |
| FILED | Wednesday, August 17, 2022 |
| APPL NO | 17/820418 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) A61P 31/14 (20180101) A61P 31/18 (20180101) Peptides C07K 16/10 (20130101) C07K 16/109 (20130101) Original (OR) Class C07K 16/1018 (20130101) C07K 16/1045 (20130101) C07K 16/1232 (20130101) C07K 2317/31 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20230117049 | Dabiri et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Dana Dabiri (Seattle, Washington); Guozhong Cao (Seattle, Washington); Wenwen Yin (Seattle, Washington) |
| ABSTRACT | A method for modulating the piasmonic resonance of a noble metal nanoparticle to enhance the luminescence of an oxygen sensitive dye; an oxygen sensitive composition that includes a nanostructure comprising a noble metal particle and an oxygen sensitive dye: a substrate having a surface coated with the oxygen sensitive composition; methods and sensors for determining oxygen concentration using the oxygen sensitive composition. |
| FILED | Thursday, February 11, 2021 |
| APPL NO | 17/904006 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/87 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/648 (20130101) G01N 2021/6432 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230117159 | Lee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chi Hwan Lee (West Lafayette, Indiana); Zahyun Ku (Beavercreek, Ohio); Augustine Michael Urbas (Oakwood, Ohio); Bongjoong Kim (West Lafayette, Indiana) |
| ABSTRACT | Nanoassembly methods for producing quasi-3D plasmonic films with periodic nanoarrays of nano-sized surface features. A sacrificial layer is deposited on a surface of a donor substrate having periodic nanoarrays of nanopattern features formed thereon. A plasmon film is deposited onto the sacrificial layer and a dielectric spacer is deposited on the plasmon film. The donor substrate having the sacrificial layer, plasmon film, and dielectric spacer thereon is immersed in a bath of etchant to selectively remove the sacrificial layer such that the plasmon film and the dielectric spacer thereon adhere to the surface of the donor substrate. The dielectric spacer and the plasmon film are mechanically separated from the donor substrate to define a quasi-three dimensional (3D) plasmonic film having periodic nanoarrays of nano-sized surface features defined by the nanopattern features of the donor substrate surface. The quasi-3D plasmonic film is then applied to a receiver substrate. |
| FILED | Friday, December 02, 2022 |
| APPL NO | 18/061052 |
| CURRENT CPC | Nanostructures Formed by Manipulation of Individual Atoms, Molecules, or Limited Collections of Atoms or Molecules as Discrete Units; Manufacture or Treatment Thereof B82B 3/0014 (20130101) Original (OR) Class Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Optical Elements, Systems, or Apparatus G02B 5/008 (20130101) G02B 2207/101 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230117290 | Czubarow et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Pawel Czubarow (Wellesley, Massachusetts); Anthony Nicholas Czubarow (Wellesley, Massachusetts); Philip Abraham Premysler (Falls Church, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pawel Czubarow (Wellesley, Massachusetts); Anthony Nicholas Czubarow (Wellesley, Massachusetts); Philip Abraham Premysler (Falls Church, Virginia) |
| ABSTRACT | Methods of making various fibers are provided including co-axial fibers with oppositely doped cladding and core are provide; hollow core doped silicon carbide fibers are provided; and doubly clad PIN junction fibers are provided. Additionally methods are provided for forming direct PN junctions between oppositely doped fibers are provided. Various thermoelectric generators that incorporate the aforementioned fibers are provided. |
| FILED | Wednesday, December 07, 2022 |
| APPL NO | 18/076845 |
| CURRENT CPC | Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 41/00 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 35/20 (20130101) H01L 35/30 (20130101) H01L 35/32 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230117831 | CHOUDHARY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BROAD INSTITUTE, INC. (CAMBRIDGE, Massachusetts); THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (BOSTON, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amit CHOUDHARY (Boston, Massachusetts); Sophia LAI (Boston, Massachusetts); Veronika SHOBA (Cambridge, Massachusetts); Praveen KOKKONDA (Boston, Massachusetts); Dhanushka MUNKANATTA GODAGE (Cambridge, Massachusetts); Sachini SIRIWARDENA (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure relates to multifunctional chemical conjugation molecules, which find utility as modifiers of target substrates. The present disclosure includes multifunctional compounds comprising a localizing moiety, a chemical linker moiety, an activator moiety, a first orienting adaptor interconnecting the chemical linker moiety on one end to the activator moiety, and optionally a second orienting adaptor interconnecting the chemical linker molecule on a different end to the localizing moiety. Molecules according to the present invention find use making post-translational modifications to macromolecules that are not the natural substrate of the activator moiety. Diseases or disorders may be treated or prevented with molecules of the present disclosure. |
| FILED | Friday, January 08, 2021 |
| APPL NO | 17/791811 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/551 (20130101) A61K 47/55 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230118039 | Brewer |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Micron Technology, Inc (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tony Brewer (Plano, Texas) |
| ABSTRACT | Implementations of the present disclosure are directed to systems and methods for reducing design complexity and critical path timing challenges of credit return logic. A wide bus supports simultaneous transmission of multiple flits, one per lane of the wide bus. A source device transmitting flits on a wide bus selects from among multiple credit return options to ensure that only one of the multiple flits being simultaneously transmitted includes a credit return value. In some example embodiments, the receiving device checks only the flit of one lane of the wide bus (e.g., lane 0) for credit return data. In other example embodiments, the receiving device uses a bitwise-OR to combine the credit return data of all received flits in a single cycle. |
| FILED | Tuesday, December 20, 2022 |
| APPL NO | 18/085274 |
| CURRENT CPC | Electric Digital Data Processing G06F 13/364 (20130101) Original (OR) Class G06F 30/3953 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230118114 | Dziubla et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas D. Dziubla (Lexington, Kentucky); Md. Arif Khan (Lexington, Kentucky); Alexander G. Rabchevsky (Nicholasville, Kentucky); Samirkumar P. Patel (Lexington, Kentucky); Jason DeRouchey (Lexington, Kentucky); Patrick G. Sullivan (Nicholasville, Kentucky) |
| ABSTRACT | This disclosure relates to hydrogel compositions with isolated mitochondria suspended therein. The compositions are for providing protection to injured tissue, as well as tissue proximal to a site of injury. The hydrogel provides structural support while the mitochondria are able to prevent or slow cellular death. In some aspects, the compositions include N-acetylcysteine amide and/or acetyl-L-carnitine. |
| FILED | Tuesday, October 04, 2022 |
| APPL NO | 17/959809 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/0085 (20130101) A61K 31/16 (20130101) A61K 31/225 (20130101) A61K 35/34 (20130101) Original (OR) Class A61K 47/36 (20130101) A61K 47/38 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230118489 | Han et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | AT and T Intellectual Property I, L.P. (Atlanta, Georgia); Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | AT and T Intellectual Property I, L.P. (Atlanta, Georgia); Regents of the University of Minnesota (Minneapolis, Minnesota) |
| INVENTOR(S) | Bo Han (Bridgewater, New Jersey); Vijay Gopalakrishnan (Edison, New Jersey); Marco Platania (Maplewood, New Jersey); Zhi-Li Zhang (Eden Prairie, Minnesota); Yang Zhang (St. Paul, Minnesota) |
| ABSTRACT | The concepts and technologies disclosed herein are directed to a network-assisted Raft consensus protocol, referred to herein as “NetRaft.” According to one aspect of the concepts and technologies disclosed herein, a system can include a plurality of servers operating in a server cluster, and a plurality of P4 switches corresponding to the plurality of servers. Each server of the plurality of servers can include a back-end that executes a complete Raft algorithm to perform leader election, log replication, and log commitment of a Raft consensus algorithm. Each P4 switch of the plurality of P4 switches can include a front-end that executes a partial Raft algorithm to perform the log replication and the log commitment of the Raft consensus algorithm. The back-end can maintain a complete state for responding to requests that cannot be fulfilled by the front-end. The requests can include read requests and/or write requests. |
| FILED | Monday, December 19, 2022 |
| APPL NO | 18/083939 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 41/0668 (20130101) Original (OR) Class H04L 45/64 (20130101) H04L 49/355 (20130101) H04L 67/1051 (20130101) H04L 67/1093 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230119558 | PETROVICS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gyorgy PETROVICS (Bethesda, Maryland); Shiv K. SRIVASTAVA (Potomac, Maryland) |
| ABSTRACT | The present disclosure provides DNA Damage Repair gene (DDRG) panels and methods of using the same for genetic testing and genetic counseling to predict a predisposition to cancer, including prostate cancer. The gene panels can be used to stratify prostate cancer patients according to disease severity and/or aggressiveness or to identify and/or stratify a patient for cancer treatment. Also provided are kits for use in predicting, diagnosing, and/or prognosing cancer. |
| FILED | Friday, March 05, 2021 |
| APPL NO | 17/909500 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6858 (20130101) C12Q 1/6886 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230119749 | MICCIANCIO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duality Technologies, Inc. (Maplewood, New Jersey) |
| ASSIGNEE(S) | Duality Technologies, Inc. (Maplewood, New Jersey) |
| INVENTOR(S) | Daniele MICCIANCIO (San Diego, California); Yuriy Polyakov (Fair Lawn, New Jersey); Zeyu Liu (Long Island City, New York) |
| ABSTRACT | Systems and methods for improving homomorphic encryption are provided. A processor receives an encrypted ciphertext; splits the encrypted ciphertext into a plurality of smaller digits; applies a homomorphic floor function to clear a least significant bit from a current smaller digit; scales down the encrypted ciphertext, using modulus switching, thereby changing the ciphertext modulus to a new modulus; applies a bootstrapping procedure for a sign evaluation function to determine a sign of the scaled down encrypted ciphertext; and transmits the sign with the ciphertext to a server for subsequent use. |
| FILED | Monday, October 03, 2022 |
| APPL NO | 17/958590 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/008 (20130101) Original (OR) Class H04L 9/0618 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230119934 | BOWMAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a Body Corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | CHRISTOPHER N. BOWMAN (BOULDER, Colorado); BRADY T. WORRELL (BOULDER, Colorado); GAYLA BERG LYON (MEDFORD, Massachusetts); MATTHEW K. MCBRIDE (BOULDER, Colorado); CHEN WANG (BOULDER, Colorado) |
| ABSTRACT | The present invention relates to covalent adaptable networks (CANs) having exchangeable crosslinks which are able to undergo repeated covalent bond reshuffling through photo-activation at ambient temperatures. The invention provides covalent adaptable network forming compositions as well as methods of forming, remolding and recycling the CANs of the invention. |
| FILED | Tuesday, November 15, 2022 |
| APPL NO | 17/987710 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/775 (20130101) C08G 18/3876 (20130101) C08G 18/8166 (20130101) C08G 75/26 (20130101) Original (OR) Class C08G 75/045 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230120443 | Rye et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric Charles Rye (Severna Park, Maryland); Robert Edward Beverly, IV (Carmel, California) |
| ABSTRACT | The invention relates to discovering and clustering Internet protocol addresses. For example, the invention can include discovering an IPv6 address of an Internet-facing device on a network, where the IPv6 address is associated with a wide area network (WAN) media access control (MAC) address and a WiFi basic service set identifier (BSSID), identifying an associated BSSID in WiFi geolocation databases based on the WAN and WiFi BSSID, and geolocating the Internet-facing device by retrieving a location record in the WiFi geolocation databases for the associated BSSID. |
| FILED | Friday, October 14, 2022 |
| APPL NO | 17/966537 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 61/5007 (20220501) Original (OR) Class H04L 2101/659 (20220501) Wireless Communication Networks H04W 8/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230120908 | Cathey |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | 3D Systems, Inc. (Rock Hill, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Turner Ashby Cathey (Rock Hill, South Carolina) |
| ABSTRACT | A three-dimensional (3D) printing system includes a print engine chassis, a build box, a vertical movement mechanism, a powder dispensing module, a consolidation module, and a controller. The print engine chassis defines a build chamber configured to receive and support the build box. The build box includes a build plate upon which the 3D article is fabricated. The vertical movement mechanism includes a plurality of actuators configured to collectively provide precise positioning of the build plate. The controller is configured to (1) operate the vertical movement mechanism including operating the plurality of actuators to position an upper surface of the 3D article generally proximate and parallel to a build plane, (2) operate the powder dispensing module to dispense a new layer of powder over the upper surface, and (3) operate the consolidation module to selectively consolidate the new layer of powder. |
| FILED | Friday, October 14, 2022 |
| APPL NO | 17/966163 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 12/30 (20210101) B22F 12/38 (20210101) B22F 12/222 (20210101) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 30/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230120926 | Thomas et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Coreform LLC (Orem, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Derek C. Thomas (Orem, Utah); Michael A. Scott (American Fork, Utah) |
| ABSTRACT | U-splines are a novel approach to the construction of a spline basis for representing smooth objects in Computer-Aided Design (CAD) and Computer-Aided Engineering (CAE). A spline is a piecewise-defined function that satisfies continuity constraints between adjacent cells in a mesh. U-splines differ from existing spline constructions, such as Non-Uniform Rational B-splines (NURBS), subdivision surfaces, T-splines, and hierarchical B-splines, in that they can accommodate local variation in cell size, polynomial degree, and smoothness simultaneously over more varied mesh configurations. Mixed cell types (e.g., triangle and tetrahedron and quadrilateral and hexahedral cells in the same mesh) and T-junctions are also supported. The U-spline construction is presented for curves, surfaces, and volumes with higher dimensional generalizations possible. A set of requirements are given to ensure that the U-spline basis is positive, forms a partition of unity, is complete, and is locally linearly independent. |
| FILED | Friday, April 01, 2022 |
| APPL NO | 17/711874 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/12 (20200101) Original (OR) Class G06F 30/23 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230120968 | Abu-Ghazaleh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for the State University of New York (Binghamton, New York) |
| ASSIGNEE(S) | The Research Foundation for the State University of New York (Binghamton, New York) |
| INVENTOR(S) | Nael Abu-Ghazaleh (Vestal, New York); Weishuai Yang (Ozone Park, New York); Michael Lewis (Vestal, New York) |
| ABSTRACT | A cluster of nodes, comprising: a plurality of nodes, each having a security policy, and being associated task processing resources; a registration agent configured to register a node and issue a node certificate to the respective node; a communication network configured to communicate certificates to authorize access to computing resources, in accordance with the respective security policy; and a processor configured to automatically dynamically partition the plurality of nodes into subnets, based on at least a distance function of at least one node characteristic, each subnet designating a communication node for communicating control information and task data with other communication nodes, and to communicate control information between each node within the subnet and the communication node of the other subnets. |
| FILED | Wednesday, October 05, 2022 |
| APPL NO | 17/960251 |
| CURRENT CPC | Electric Digital Data Processing G06F 15/16 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 41/12 (20130101) H04L 43/10 (20130101) H04L 47/70 (20130101) H04L 67/02 (20130101) H04L 67/10 (20130101) H04L 67/51 (20220501) H04L 67/1044 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230121080 | Chapin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California); the United States of America as represented by the Secretary of the Army (Huntsville, Alabama); BAE Systems Land and Armaments L.P. (Sterling Heights, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Caitlin Anne Chapin (Fremont, California); Lars F. Voss (Livermore, California); Luis M. Hernandez (Coon Rapids, Minnesota); Mark Rader (Decatur, Alabama) |
| ABSTRACT | In one general embodiment, a structure includes a first diode, comprising: a first layer having a first type of dopant, and a second layer above the first layer, the second layer having a second type of dopant that is opposite to the first type of dopant. A second diode is formed directly on the first diode. The second diode comprises a first layer having a third type of dopant and a second layer above the first layer of the second diode, the second layer of the second diode having a fourth type of dopant that is opposite to the third type of dopant. In another general embodiment, a process includes a repeated sequence of growing a first layer having a first type of electrically active dopant and growing a second layer having a second type of electrically active dopant that is opposite to the first type of dopant. |
| FILED | Monday, October 17, 2022 |
| APPL NO | 17/967754 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/866 (20130101) Original (OR) Class H01L 29/66151 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230121158 | Meinhart et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Michael A. Meinhart (Washington, Indiana); Bryan Daugherty (Sandborn, Indiana) |
| ABSTRACT | Apparatus and methods are provided in relation to an autonomous computer system that can defend against known and unknown virus and malware attacks. Various embodiments include a Virus Autonomous Defense System (VADS) can on its own without human intervention once it is turned on. Embodiments can incorporate hardware coupled with various types of artificial Intelligence software and systems to perform response functions including closing ports that are being compromised, analyze an attack, and develop software scripts (signatures) to defend against future attacks, and create responses which defeat an attack that can include a follow on response of freeing up an attacked port for continual operation. |
| FILED | Thursday, August 11, 2022 |
| APPL NO | 17/885959 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/566 (20130101) Original (OR) Class G06F 2221/034 (20130101) Computer Systems Based on Specific Computational Models G06N 5/01 (20230101) G06N 5/025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230121235 | Gunn et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | L3Harris Technologies, Inc. (Melbourne, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joshua D. Gunn (Farmington, Utah); Ryan W. Hinton (Erda, Utah); Edwin J. Hemphill (Kaysville, Utah) |
| ABSTRACT | A method for mitigating interference in a frequency hopping channel system based on codeword metrics obtained during decoding of codewords. The method includes decoding a plurality of codewords using a particular error control coding method. Each of the plurality of codewords includes portions received from plurality of channels in the frequency hopping channel system. For each decoded codeword, one or more codeword metrics are obtained based on the cost of correcting errors during decoding of the plurality of codewords. Based on the codeword metrics, one or more channel metrics are inferred. Based on the inferred one or more channel metrics, a reliability metric of a particular channel is reduced, or incoming symbols received from the particular channel are ignored during decoding. |
| FILED | Tuesday, October 19, 2021 |
| APPL NO | 17/504985 |
| CURRENT CPC | Transmission H04B 1/715 (20130101) Original (OR) Class H04B 1/7143 (20130101) H04B 17/318 (20150115) H04B 17/345 (20150115) H04B 2001/7152 (20130101) H04B 2001/71563 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230121359 | Iacono et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott T. Iacono (Colorado Springs, Colorado); Chadron M. Friesn (Langley, Canada) |
| ABSTRACT | The present invention relates to a mechanochemical based synthesis of perfluoropyridine monomers, polymers made using such monomers and methods of making and using articles comprising such polymers. Such perfluoropyridine monomers are easily chemically tuned have the strength needed for high temperature applications and the flexibility needed for low temperature applications. In addition, to the aforementioned monomers, a mechanochemical based synthesis for such perfluoropyridine monomers is provided. All of the aforementioned performance application advantages are also found in polymers comprising Applicants' perfluoropyridine monomers. |
| FILED | Monday, December 05, 2022 |
| APPL NO | 18/075018 |
| CURRENT CPC | Heterocyclic Compounds C07D 213/61 (20130101) Original (OR) Class Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 73/0627 (20130101) Cracking Hydrocarbon Oils; Production of Liquid Hydrocarbon Mixtures, e.g by Destructive Hydrogenation, Oligomerisation, Polymerisation; Recovery of Hydrocarbon Oils From Oil-shale, Oil-sand, or Gases; Refining Mixtures Mainly Consisting of Hydrocarbons; Reforming of Naphtha; Mineral Waxes C10G 71/00 (20130101) Lubricating Compositions; Use of Chemical Substances Either Alone or as Lubricating Ingredients in a Lubricating Composition C10M 147/04 (20130101) C10M 169/041 (20130101) C10M 2203/003 (20130101) C10M 2213/06 (20130101) Indexing Scheme Associated With Subclass C10M Relating to Lubricating Compositions C10N 2050/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20230121487 — NANOCARBON COATING SYSTEM AND COATING METHOD FOR STRAY AND REFLECTED LIGHT SUPPRESSION
| US 20230121487 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Faraday Technology, Inc. (Englewood, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dan Wang (Dublin, Ohio); Timothy David Hall (Englewood, Ohio); Maria E. Inman (Yellow Springs, Ohio); Rajeswaran Radhakrishnan (Beavercreek, Ohio); Earl Jennings Taylor (Troy, Ohio) |
| ABSTRACT | A method of coating a substrate, the method comprises adding a nanocarbon material to an electrophoretic solution in an electrophoretic deposition apparatus including the substrate and an electrode spaced from the substrate, and applying a current to the substrate and the electrode to deposit the nanocarbon material onto the substrate. |
| FILED | Tuesday, September 27, 2022 |
| APPL NO | 17/953885 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 5/18 (20130101) C25D 9/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230121917 | Minn et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andy J. Minn (Philadelphia, Pennsylvania); Barzin Y. Nabet (Menlo Park, California); Lexus R. Johnson (Philadelphia, Pennsylvania) |
| ABSTRACT | The present invention includes methods for detecting cancer in a subject and measuring the effectiveness of a cancer treatment. In certain embodiments, the invention includes assessing the level of unshielded RN7SL1 RNA in a sample from a subject. |
| FILED | Thursday, May 19, 2022 |
| APPL NO | 17/749039 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7105 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/117 (20130101) C12N 2310/14 (20130101) C12N 2310/17 (20130101) C12N 2310/20 (20170501) C12N 2330/10 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230122182 | CAMAYD-MUNOZ et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Philip CAMAYD-MUNOZ (Pasadena, California); Conner BALLEW (Pasadena, California); Gregory ROBERTS (Pasadena, California); Andrei FARAON (Pasadena, California) |
| ABSTRACT | Methods and devices to build and use multi-functional scattering structures. The disclosed methods and devices account for multiple target functions and can be implemented using fabrication methods based on two-photon polymerization or multi-layer lithography. Exemplary devices functioning as wave splitters are also described. Results confirming the performance and benefits of the disclosed teachings are also described. |
| FILED | Wednesday, June 29, 2022 |
| APPL NO | 17/853540 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 5/0236 (20130101) G02B 27/1013 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/14625 (20130101) H01L 27/14645 (20130101) H01L 27/14685 (20130101) Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 1/207 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230122344 | Lindsley et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Craig W. Lindsley (Brentwood, Tennessee); P. Jeffrey Conn (Nashville, Tennessee); Aaron M. Bender (Spring Hill, Tennessee); Matthew Spock (Nashville, Tennessee); Changho Han (Nashville, Tennessee) |
| ABSTRACT | Disclosed herein are substituted hexahydro-1H-cyclopenta[c]pyrrole compounds, which may be useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions. |
| FILED | Thursday, December 10, 2020 |
| APPL NO | 17/784356 |
| CURRENT CPC | Heterocyclic Compounds C07D 403/14 (20130101) C07D 405/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230122364 | CROWE, Jr. et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James E. CROWE, Jr. (Nashville, Tennessee); Seth ZOST (Nashville, Tennessee); Robert CARNAHAN (Nashville, Tennessee); Pavlo GILCHUK (Nashville, Tennessee) |
| ABSTRACT | The present disclosure is directed to antibodies binding to and neutralizing tire coronavirus designated SARS-CoV-2 and methods for use thereof. |
| FILED | Friday, March 26, 2021 |
| APPL NO | 17/907320 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/545 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/10 (20130101) Original (OR) Class C07K 2317/52 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) G01N 2333/165 (20130101) G01N 2469/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230122594 | Reiserer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ronald S. Reiserer (Nashville, Tennessee); David K. Schaffer (Nashville, Tennessee); Philip C. Samson (Nashville, Tennessee); Dmitry A. Markov (Nashville, Tennessee); Michael Geuy (Nashville, Tennessee); Lisa J. McCawley (Nashville, Tennessee); John P. Wikswo (Brentwood, Tennessee) |
| ABSTRACT | Microfluidic systems, pumps, valves and applications of the same are provided. The microfluidic system may be a pump or a valve having a fluidic chip and an actuator controlling the opening and closing of the fluidic channel in the fluidic chip. The actuator may be disposed to tilt from the fluidic chip, forming a tilted-rotor peristaltic pump. Alternatively, the actuator may be a rolling ball actuator, and different fluidic chips may be used in different applications. For example, the fluidic chip may be a spiral pump chip having spiral channels, a rotary peristaltic pump chip having multiple output channels, or a multi-port valve chip having one port interconnected with multiple different ports. An analytical valve chip may switchably interconnect bioreactor and rinse/calibration input channels to sensor and waste output channels. The actuator of a random-access valve can move from one valve position to another without opening or closing intermediate ones. |
| FILED | Tuesday, December 20, 2022 |
| APPL NO | 18/084634 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502738 (20130101) Original (OR) Class B01L 2300/123 (20130101) B01L 2300/0627 (20130101) B01L 2400/0644 (20130101) Positive-displacement Machines for Liquids; Pumps F04B 43/1261 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230122855 | Edinger et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); The Université de Montréal (Montreal, Canada) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California); The Université de Montréal (Montreal, Canada) |
| INVENTOR(S) | Aimee L. Edinger (Irvine, California); Stephen Hanessian (Irvine, California) |
| ABSTRACT | Small molecules comprised of azacyclic constrained sphingolipid-like compounds and methods of their synthesis are provided. Formulations and medicaments are also provided that are directed to the treatment of disease, such as, for example, neoplasms, cancers, and other diseases. Therapeutics are also provided containing a therapeutically effective dose of one or more small molecule compounds, present either as pharmaceutically effective salt or in pure form, including, but not limited to, formulations for oral, intravenous, or intramuscular administration. |
| FILED | Thursday, October 13, 2022 |
| APPL NO | 18/046471 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/40 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 207/06 (20130101) C07D 207/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230122912 | Ji et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Utah Research Foundation (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Haitao Ji (Salt Lake City, Utah); Min Zhang (Salt Lake City, Utah) |
| ABSTRACT | In one aspect, the invention relates to 4-substituted benzoylpiperazine-1-substituted carbonyls, derivatives thereof, and related compounds; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders, e.g., various tumors and cancers, associated with β-catenin/BCL9 protein-protein interaction dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| FILED | Tuesday, October 18, 2022 |
| APPL NO | 17/968408 |
| CURRENT CPC | Heterocyclic Compounds C07D 403/12 (20130101) Original (OR) Class C07D 403/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230123204 | Medard et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Muriel Medard (Belmont, Massachusetts); Derya Malak (Boston, Massachusetts); Alejandro Cohen (Brookline, Massachusetts) |
| ABSTRACT | Techniques are disclosed for an adaptive and causal random linear network coding (AC-RLNC) with forward error correction (FEC) for a communication channel with delayed feedback. An example methodology implementing the techniques includes transmitting one or more coded packets in a communication channel, determining a channel behavior of the channel, and adaptively adjusting a transmission of a subsequent coded packet in the first channel based on the determined channel behavior. The communication channel may be a point-to-point communication channel between a sender and a receiver. The channel behavior may be determined based on feedback acknowledgements provided by the receiver. The subsequent coded packet may be a random linear combination of one or more information packets. |
| FILED | Monday, December 12, 2022 |
| APPL NO | 18/064540 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 1/004 (20130101) H04L 1/1867 (20130101) H04L 69/324 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230123421 | Bhattacharjya et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | International Business Machines Corporation (Armonk, New York) |
| INVENTOR(S) | Debarun Bhattacharjya (New York, New York); Tian Gao (Berkeley Heights, New Jersey); Dharmashankar Subramanian (White Plains, New York) |
| ABSTRACT | A computer system, computer program product, and computer-implemented method are provided that includes learning a tree ordered graphical event model from an event dataset. Temporal relationships between one or more events in received temporal event data is modeled, and an ordered graphical event model (OGEM) graph is learned. The learned OGEM graph is configured to capture ordinal historical dependence. Leveraging the learned OGEM graph, a parameter sharing architecture is learned, including order dependent statistical and causal co-occurrence relationships among event types. A control signal to an operatively coupled event device that is associated with at least one event type reflected in the learned parameter sharing environment is dynamically issued. The control signal is configured to selectively control an event injection. |
| FILED | Monday, October 18, 2021 |
| APPL NO | 17/503557 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6259 (20130101) Computer Systems Based on Specific Computational Models G06N 7/005 (20130101) G06N 20/00 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230123669 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); The Brigham and Woman's Hospital, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | David R. Liu (Cambridge, Massachusetts); Mandana Arbab (Cambridge, Massachusetts); Max Walt Shen (Cambridge, Massachusetts); Christopher Cassa (Boston, Massachusetts) |
| ABSTRACT | The present disclosure provides a novel machine learning model capable of assisting those of ordinary skill in the art to conduct base editing by, inter alia, facilitating the selection of an appropriate guide RNA and base editor combination which are capable of conducting base editing at a certain level of efficiency and specificity on a given input target DNA sequence desired to be edited to produce an outcome genotype of interest. The disclosure also provides base editors (e.g., ABEs and CBEs), napDNAbps, cytidine deaminases, adenosine deaminases, nucleic acid sequences encoding base editors and components thereof, vectors, and cells. In addition, the disclosure provides methods of making biological or experimental training and/or validation data for training and/or validating the machine learning computational models, as well as, vectors, libraries, and nucleic acid sequences for use in obtaining said experimental training and/or validation data. |
| FILED | Friday, February 05, 2021 |
| APPL NO | 17/797697 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/50 (20190201) G16B 40/00 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230123989 | Kaplan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David L. Kaplan (Concord, Massachusetts); Krishna Kumar (Cambridge, Massachusetts); Vittorio Montanari (Medford, Massachusetts); Morgan Hawker (Clovis, California); Julia Fountain (Medford, Massachusetts); Junqi Wu (Medford, Massachusetts) |
| ABSTRACT | The present disclosure relates to compositions, methods of making, and methods of using a modified silk-based composition having a selectively tunable hydrophobicity. The provided compositions include silk fibroin having a haloalkyl substituent. The haloalkyl substituent is coupled to an amino acid of the silk fibroin though a linking agent. |
| FILED | Thursday, March 25, 2021 |
| APPL NO | 17/907404 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1767 (20130101) Original (OR) Class Derivatives of Natural Macromolecular Compounds C08H 1/00 (20130101) Compositions of Macromolecular Compounds C08L 89/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230124247 | Roychoudhury et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PRECISION COMBUSTION, INC. (North Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Subir Roychoudhury (Madison, Connecticut); Richard Mastanduno (Milford, Connecticut); Francesco Macri (Farmington, Connecticut); Bruce Crowder (Hamden, Connecticut) |
| ABSTRACT | A thermophotovoltaic generator incorporating a two-stage combustor for providing heat to a thermophotovoltaic cell. Combustor parts include a partial oxidation reactor, which functions catalytically to convert a hydrocarbon fuel and a first supply of an oxidant into a gaseous partial oxidation product; and further include downstream thereof, a deep oxidation reactor including a premixer plenum fluidly connected to a heat spreader comprising a porous matrix, such as a ceramic foam. Functionally, the deep oxidation reactor converts the gaseous partial oxidation product and a second supply of oxidant into complete combustion products. Heat produced by the two-stage combustor generates radiative energy from a photon emitter, which is directly converted to electricity in a photovoltaic diode cell. |
| FILED | Wednesday, December 14, 2022 |
| APPL NO | 18/080923 |
| CURRENT CPC | Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 10/10 (20141201) H02S 10/30 (20141201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230124253 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jin Chen (San Francisco, California); Luke Gilbert (San Francisco, California); James Nunez (San Francisco, California); Jonathan Weissman (San Francisco, California) |
| ABSTRACT | Provided herein are, inter alia, compositions and methods for manipulation of genomes of living organisms. |
| FILED | Friday, July 29, 2022 |
| APPL NO | 17/816369 |
| CURRENT CPC | Peptides C07K 14/4702 (20130101) C07K 2319/09 (20130101) C07K 2319/33 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/20 (20130101) C12N 9/1007 (20130101) C12N 15/62 (20130101) Original (OR) Class C12N 15/113 (20130101) Enzymes C12Y 201/01072 (20130101) C12Y 301/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230124363 | Adams et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States, as represented by the Secretary of the Army (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Adams (Norman, Oklahoma); William Toth (Ocean, New Jersey); Matthew Lazzaro (Churchville, Maryland); Todd Lutton (New Windsor, Maryland); Michael Neuman (Vashon, Washington); Diana Neuman (Vashon, Washington); Stanley Fong (Hazlet, New Jersey) |
| ABSTRACT | Various embodiments that relate to local communication are discussed. A radio from one geographical area can enter a communication environment of a different geographical area. However, if the radio still functions consistent with the previous geographical area, then the radio will not blend into the new geographical area. Therefore, the radio can alter operational characteristics when entering the new geographical area such that the radio blends into the new geographical area from a radio frequency perspective. |
| FILED | Tuesday, October 19, 2021 |
| APPL NO | 17/504775 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 1/0003 (20130101) Wireless Communication Networks H04W 4/025 (20130101) Original (OR) Class H04W 8/22 (20130101) H04W 72/0453 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230124554 | Jiang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Shaoyi Jiang (Redmond, Washington); Tao Bai (Seattle, Washington); Jean-René Ella-Menye (Seattle, Washington); Hsiang-Chieh Hung (Seattle, Washington); Priyesh Jain (Seattle, Washington); Andrew Sinclair (Seattle, Washington); Harihara Subramanian Sundaram (Seattle, Washington); Yang Li (Seattle, Washington); Peng Zhang (Seattle, Washington) |
| ABSTRACT | Free-standing non-fouling polymers and polymeric compositions, monomers and macromonomers for making the polymers and polymeric compositions, objects made from the polymers and polymeric compositions, and methods for making and using the polymers and polymeric compositions |
| FILED | Monday, November 28, 2022 |
| APPL NO | 18/059104 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/58 (20170801) A61K 47/59 (20170801) A61K 47/593 (20170801) A61K 47/595 (20170801) Acyclic or Carbocyclic Compounds C07C 229/12 (20130101) C07C 229/16 (20130101) C07C 237/22 (20130101) C07C 253/30 (20130101) C07C 255/23 (20130101) C07C 255/26 (20130101) C07C 265/04 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/091 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 220/34 (20130101) Original (OR) Class C08F 220/36 (20130101) C08F 220/42 (20130101) C08F 220/44 (20130101) C08F 220/48 (20130101) C08F 220/50 (20130101) C08F 220/603 (20200201) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/78 (20130101) C08G 18/3821 (20130101) C08G 61/06 (20130101) C08G 61/08 (20130101) C08G 61/12 (20130101) C08G 63/6856 (20130101) C08G 69/26 (20130101) C08G 69/42 (20130101) C08G 73/0206 (20130101) C08G 73/0226 (20130101) C08G 73/0233 (20130101) C08G 73/0611 (20130101) Compositions of Macromolecular Compounds C08L 35/02 (20130101) C08L 65/00 (20130101) C08L 67/02 (20130101) C08L 75/04 (20130101) C08L 77/06 (20130101) C08L 79/02 (20130101) C08L 79/04 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/1637 (20130101) C09D 5/1662 (20130101) C09D 7/65 (20180101) C09D 135/02 (20130101) C09D 165/00 (20130101) C09D 167/02 (20130101) C09D 175/04 (20130101) C09D 177/06 (20130101) C09D 179/02 (20130101) C09D 179/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230124957 | STONE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | APG Cash Drawer, LLC (Fridley, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Hamilton STONE (Woodstock, Georgia); Scott Benjamin JOHNSON (Minneapolis, Minnesota); Nicholas Edward Maffey (Atlanta, Georgia); Russell Joseph Kroll (Atlanta, Georgia) |
| ABSTRACT | Embodiments of a cashdrawer exoskeleton system are disclosed. In one embodiment, a modular base piece has an integrated fastener configured to facilitate a coupling to a cash drawer. An aperture is formed through the top surface of the modular base piece and leads to an area where the cash drawer is positioned when the modular base piece is coupled to the cash drawer utilizing the integrated fastener. At least one spacer is then configured to facilitate creation of a gap between the modular base piece and the cash drawer when the modular base piece is coupled to the cash drawer utilizing the integrated fastener. |
| FILED | Wednesday, October 19, 2022 |
| APPL NO | 17/969093 |
| CURRENT CPC | Registering the Receipt of Cash, Valuables, or Tokens G07G 1/0027 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230125057 | VAN VOORHIS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington); United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wesley C. VAN VOORHIS (Seattle, Washington); Dustin James MALY (Seattle, Washington); Kayode K. OJO (Seattle, Washington); Gayani PERERA (Seattle, Washington); Stephen R. PLYMATE (Seattle, Washington); Cynthia SPRENGER (Seattle, Washington); Takuma UO (Seattle, Washington); Rama Subba Rao VIDADALA (Seattle, Washington) |
| ABSTRACT | This disclosure relates to compounds, pharmaceutical compositions comprising them, and methods of using the compounds and compositions for treating diseases affected by glycolytic generation of adenosine triphosphate (ATP). More particularly, this disclosure relates to compounds and pharmaceutical compositions thereof, methods of selectively inhibiting glycolysis with these compounds, and methods of treating diseases that benefit from selective glycolysis inhibition, such as cancer. |
| FILED | Thursday, January 07, 2021 |
| APPL NO | 17/758577 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 487/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20230117150 | Jewett et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois); THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael C. Jewett (Evanston, Illinois); Alexander S. Mankin (River Forest, Illinois); Nikolay Aleksashin (Chicago, Illinois) |
| ABSTRACT | Disclosed are engineered polynucleotides, engineered ribosomes comprising the engineered polynucleotides, engineered cells and systems comprising the engineered polynucleotides and ribosomes, and methods of making and using the engineered polynucleotides, engineered ribosomes, engineered cells and systems. The engineered polynucleotides, engineered ribosomes, and engineered cells may be utilized to prepare sequence defined polymers and to select for mutant ribosomes that are capable of incorporating non-canonical amino acids into a polymer. |
| FILED | Wednesday, March 24, 2021 |
| APPL NO | 17/907191 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/14 (20130101) C12N 9/104 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/02 (20130101) Original (OR) Class Enzymes C12Y 203/02012 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230117159 | Lee et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chi Hwan Lee (West Lafayette, Indiana); Zahyun Ku (Beavercreek, Ohio); Augustine Michael Urbas (Oakwood, Ohio); Bongjoong Kim (West Lafayette, Indiana) |
| ABSTRACT | Nanoassembly methods for producing quasi-3D plasmonic films with periodic nanoarrays of nano-sized surface features. A sacrificial layer is deposited on a surface of a donor substrate having periodic nanoarrays of nanopattern features formed thereon. A plasmon film is deposited onto the sacrificial layer and a dielectric spacer is deposited on the plasmon film. The donor substrate having the sacrificial layer, plasmon film, and dielectric spacer thereon is immersed in a bath of etchant to selectively remove the sacrificial layer such that the plasmon film and the dielectric spacer thereon adhere to the surface of the donor substrate. The dielectric spacer and the plasmon film are mechanically separated from the donor substrate to define a quasi-three dimensional (3D) plasmonic film having periodic nanoarrays of nano-sized surface features defined by the nanopattern features of the donor substrate surface. The quasi-3D plasmonic film is then applied to a receiver substrate. |
| FILED | Friday, December 02, 2022 |
| APPL NO | 18/061052 |
| CURRENT CPC | Nanostructures Formed by Manipulation of Individual Atoms, Molecules, or Limited Collections of Atoms or Molecules as Discrete Units; Manufacture or Treatment Thereof B82B 3/0014 (20130101) Original (OR) Class Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Optical Elements, Systems, or Apparatus G02B 5/008 (20130101) G02B 2207/101 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230117370 | Beaudry et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Oregon State University (Corvallis, Oregon) |
| ASSIGNEE(S) | Oregon State University (Corvallis, Oregon) |
| INVENTOR(S) | Christopher M. Beaudry (Corvallis, Oregon); Xiaojie Zhang (Corvallis, Oregon) |
| ABSTRACT | Disclosed herein are embodiments of a method for making substituted compounds with specific and selectable regiochemistry. Also disclosed are compounds made by the method. The method may comprise contacting a compound having a formula I with a compound according to formula II in the presence of a Lewis acid to form a phenol compound according to formula III and/or a benzofuranone compound according to formula IV |
| FILED | Friday, October 14, 2022 |
| APPL NO | 18/046583 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 37/07 (20130101) Original (OR) Class Heterocyclic Compounds C07D 307/83 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230117830 | Szostak et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michal Szostak (Newark, New Jersey); Shicheng Shi (Newark, New Jersey) |
| ABSTRACT | The present disclosure provides, in part, a new class of highly active Pd(II)-NHC complexes bearing anilines as throw-away ligands. These catalysts are well-defined, air- and moisture-stable, and can be easily purified by chromatographic techniques. High activity and generality has been exemplified in the Suzuki-Miyaura cross-coupling by C—N, C—O and C—Cl cleavage. Facile syntheses of these catalysts is also described. |
| FILED | Friday, January 08, 2021 |
| APPL NO | 17/791684 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/181 (20130101) B01J 31/2273 (20130101) Original (OR) Class B01J 2231/4211 (20130101) B01J 2231/4283 (20130101) B01J 2531/824 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 15/006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230117980 | Ding et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of Arizona State University (Tempe, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on Behalf of Arizona State University (Tempe, Arizona); The Texas A and M University System (College Station, Texas) |
| INVENTOR(S) | Kaize Ding (Tempe, Arizona); Jianling Wang (College, Texas); Huan Liu (Tempe, Arizona) |
| ABSTRACT | A system employs Graph Prototypical Networks (GPN) for few-shot node classification on attributed networks, and a meta-learning framework trains the system by constructing a pool of semi-supervised node classification tasks to mimic the real test environment. The system is able to perform meta-learning on an attributed network and derive a highly generalizable model for handling the target classification task. The meta-learning framework addresses extraction of meta-knowledge from an attributed network for few-shot node classification, and identification of the informativeness of each labeled instance for building a robust and effective model. |
| FILED | Thursday, October 06, 2022 |
| APPL NO | 17/938589 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/628 (20130101) G06K 9/6215 (20130101) G06K 9/6232 (20130101) G06K 9/6296 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230118489 | Han et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | AT and T Intellectual Property I, L.P. (Atlanta, Georgia); Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | AT and T Intellectual Property I, L.P. (Atlanta, Georgia); Regents of the University of Minnesota (Minneapolis, Minnesota) |
| INVENTOR(S) | Bo Han (Bridgewater, New Jersey); Vijay Gopalakrishnan (Edison, New Jersey); Marco Platania (Maplewood, New Jersey); Zhi-Li Zhang (Eden Prairie, Minnesota); Yang Zhang (St. Paul, Minnesota) |
| ABSTRACT | The concepts and technologies disclosed herein are directed to a network-assisted Raft consensus protocol, referred to herein as “NetRaft.” According to one aspect of the concepts and technologies disclosed herein, a system can include a plurality of servers operating in a server cluster, and a plurality of P4 switches corresponding to the plurality of servers. Each server of the plurality of servers can include a back-end that executes a complete Raft algorithm to perform leader election, log replication, and log commitment of a Raft consensus algorithm. Each P4 switch of the plurality of P4 switches can include a front-end that executes a partial Raft algorithm to perform the log replication and the log commitment of the Raft consensus algorithm. The back-end can maintain a complete state for responding to requests that cannot be fulfilled by the front-end. The requests can include read requests and/or write requests. |
| FILED | Monday, December 19, 2022 |
| APPL NO | 18/083939 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 41/0668 (20130101) Original (OR) Class H04L 45/64 (20130101) H04L 49/355 (20130101) H04L 67/1051 (20130101) H04L 67/1093 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230118593 | Chugunov et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF PRINCETON UNIVERSITY (Princeton, New Jersey); KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY (Princeton, Saudi Arabia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ilya Chugunov (Princeton, New Jersey); Seung-Hwan Baek (Princeton, New Jersey); Qiang` Fu (Thuwal, Saudi Arabia); Wolfgang Heidrich (Thuwal, Saudi Arabia); Felix Heide (Princeton, None) |
| ABSTRACT | The microlens amplitude masks for flying pixel removal in time-of-flight imaging includes systems, devices, methods, and instructions for image depth determination, including receiving an image, adding noise to the image, determining a set of correlation images, each correlation image having a varying phase offset, for each pixel of the image, generating a masked pixel by applying a mask array, and for each masked pixel, determining the depth of the masked pixel to generate a depth map for the image on a per pixel basis. |
| FILED | Thursday, March 17, 2022 |
| APPL NO | 17/915536 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/4816 (20130101) G01S 7/4912 (20130101) G01S 17/894 (20200101) Image Data Processing or Generation, in General G06T 7/50 (20170101) Original (OR) Class G06T 2207/10028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230118621 | Stark et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pascal Stark (Thalwil, Switzerland); Folkert Horst (Wettingen, Switzerland); Roger F. Dangel (Zug, Switzerland); Bert Jan Offrein (Schoenenberg, Switzerland); Lorenz K. Muller (Dubendorf, Switzerland) |
| ABSTRACT | A method of processing data and related apparatuses. The method relies on an optical finite impulse response (FIR) filter. This optical FIR filter comprises several delay stages having weights set in accordance with parameters of a transformation to be applied by the optical FIR filter. Each of the delay stages is configured to impose a delay matched to a given input data period corresponding to a given input sample rate. According to the method, an optical signal is coupled into the optical FIR filter. The optical signal carries a data stream of input samples encoded at the given input sample rate; the data stream represents the data to be processed. Next, output samples are collected from an output data stream carried by an output optical signal obtained in output of the optical FIR filter. A set of output samples are obtained, which are representative of processed data. |
| FILED | Wednesday, October 20, 2021 |
| APPL NO | 17/451550 |
| CURRENT CPC | Electric Digital Data Processing G06F 17/153 (20130101) Image Data Processing or Generation, in General G06T 5/20 (20130101) Impedance Networks, e.g Resonant Circuits; Resonators H03H 17/0036 (20130101) Original (OR) Class H03H 2017/0081 (20130101) H03H 2218/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230119155 | Kim et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Texas Tech University System (Lubbock, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sangsik Kim (Daejeon, South Korea); Md Borhan Mia (San Jose, California) |
| ABSTRACT | An optical waveguide includes a first waveguide core, a second waveguide core, a first subwavelength multilayer cladding, a second subwavelength multilayer cladding and a third subwavelength multilayer cladding. The first waveguide core and the second waveguide core have a width (w) and a height (h). The first waveguide core is disposed between the first subwavelength multilayer cladding and the second subwavelength multilayer cladding. The second waveguide core is disposed between the second subwavelength multilayer cladding and the third subwavelength multilayer cladding. Each subwavelength multilayer cladding has a number (TV) of alternating subwavelength ridges having a periodicy (A) and a filling fraction (p). A total coupling coefficient (|/c|) of the first waveguide core and the second waveguide core is from 10 to 0. |
| FILED | Tuesday, February 23, 2021 |
| APPL NO | 17/798167 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/12002 (20130101) Original (OR) Class G02B 2006/121 (20130101) G02B 2006/12097 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230119193 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Trustees of the University of Arkansas (Little Rock, Arkansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhong Chen (Fayetteville, Arkansas); Alan Mantooth (Fayetteville, Arkansas); Shui-qing Yu (Fayetteville, Arkansas); David Gonzalez (Fayetteville, Arkansas); Pengyu Lai (Fayetteville, Arkansas); Syam Madhusoodhanan (Fayetteville, Arkansas) |
| ABSTRACT | A high-temperature power module integrated with an optically galvanic isolated gate driver. The power module includes one or more galvanic isolated gate driver boards, where each galvanic isolated gate driver board includes an optocoupler configured to transfer electrical signals between two isolated circuitry by using light. Furthermore, each galvanic isolated gate driver board includes a gate driver connected to the optocoupler, where the gate driver includes a power amplifier that receives a signal and produces a current drive input for a gate of a transistor. |
| FILED | Tuesday, October 18, 2022 |
| APPL NO | 17/968387 |
| CURRENT CPC | Pulse Technique H03K 17/78 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230119392 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Po-Han Wang (La Jolla, California); Patrick Mercier (La Jolla, California); Dinesh Bharadia (La Jolla, California) |
| ABSTRACT | A method for communicating directly with commodity Wi-Fi transceivers (TRXs) via backscatter modulation in an integrated tag device is provided. The method includes sensing an incident Wi-Fi?compliant wake-up signal. The method than reflects the incident Wi-Fi- complaint wake-up signal by encoding data from the tag device such that the reflected signal follows the Wi-Fi standard compliant and can be decoded by another WiFi-device. An integrated device includes a downlink Wi-Fi compatible wake-up receiver that checks timing of Wi-Fi compatible signals for a wake-up packet. The device has a modulator that is turned on in response to the wake-up packet and a mixer in the modulator hat mixes tag data with a payload packet from received Wi-Fi payload. Backscatter switches backscatter the response. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/799409 |
| CURRENT CPC | Wireless Communication Networks H04W 52/0229 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230119749 | MICCIANCIO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duality Technologies, Inc. (Maplewood, New Jersey) |
| ASSIGNEE(S) | Duality Technologies, Inc. (Maplewood, New Jersey) |
| INVENTOR(S) | Daniele MICCIANCIO (San Diego, California); Yuriy Polyakov (Fair Lawn, New Jersey); Zeyu Liu (Long Island City, New York) |
| ABSTRACT | Systems and methods for improving homomorphic encryption are provided. A processor receives an encrypted ciphertext; splits the encrypted ciphertext into a plurality of smaller digits; applies a homomorphic floor function to clear a least significant bit from a current smaller digit; scales down the encrypted ciphertext, using modulus switching, thereby changing the ciphertext modulus to a new modulus; applies a bootstrapping procedure for a sign evaluation function to determine a sign of the scaled down encrypted ciphertext; and transmits the sign with the ciphertext to a server for subsequent use. |
| FILED | Monday, October 03, 2022 |
| APPL NO | 17/958590 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/008 (20130101) Original (OR) Class H04L 9/0618 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230119934 | BOWMAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a Body Corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | CHRISTOPHER N. BOWMAN (BOULDER, Colorado); BRADY T. WORRELL (BOULDER, Colorado); GAYLA BERG LYON (MEDFORD, Massachusetts); MATTHEW K. MCBRIDE (BOULDER, Colorado); CHEN WANG (BOULDER, Colorado) |
| ABSTRACT | The present invention relates to covalent adaptable networks (CANs) having exchangeable crosslinks which are able to undergo repeated covalent bond reshuffling through photo-activation at ambient temperatures. The invention provides covalent adaptable network forming compositions as well as methods of forming, remolding and recycling the CANs of the invention. |
| FILED | Tuesday, November 15, 2022 |
| APPL NO | 17/987710 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/775 (20130101) C08G 18/3876 (20130101) C08G 18/8166 (20130101) C08G 75/26 (20130101) Original (OR) Class C08G 75/045 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230120244 | Ma et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter X. Ma (Ann Arbor, Michigan); Xiaojin Zhang (Wuhan, China PRC) |
| ABSTRACT | A hyperbranched polymer includes a hyperbranched, hydrophobic molecular core, respective low molecular weight polyethyleneimine chains attached to at least three branches of the hyperbranched, hydrophobic molecular core, and respective polyethylene glycol chains attached to at least two other branches of the hyperbranched, hydrophobic molecular core. Examples of the hyperbranched polymer may be used to form hyperbranched polyplexes, and may be included in DNA or RNA delivery systems. |
| FILED | Tuesday, December 06, 2022 |
| APPL NO | 18/076030 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/50 (20170801) A61K 47/60 (20170801) A61K 47/593 (20170801) Original (OR) Class A61K 47/6937 (20170801) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) A61L 27/26 (20130101) A61L 27/44 (20130101) A61L 27/52 (20130101) A61L 27/54 (20130101) A61L 27/56 (20130101) A61L 27/58 (20130101) A61L 2300/258 (20130101) A61L 2300/604 (20130101) A61L 2430/02 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 210/02 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/66 (20130101) C08G 73/024 (20130101) C08G 73/0206 (20130101) C08G 81/00 (20130101) C08G 83/00 (20130101) C08G 83/005 (20130101) C08G 2210/00 (20130101) C08G 2230/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2310/14 (20130101) C12N 2310/51 (20130101) C12N 2310/52 (20130101) C12N 2310/141 (20130101) C12N 2310/351 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230120878 | Zhou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Little Rock, Arkansas) |
| ASSIGNEE(S) | BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Little Rock, Arkansas) |
| INVENTOR(S) | Wenchao Zhou (Fayetteville, Arkansas); Marques Lucas (Fayetteville, Arkansas); Zachary Hyden (Fayetteville, Arkansas); Pablo Guerra (Fayetteville, Arkansas) |
| ABSTRACT | The present invention provides a swarm manufacturing platform, based on a swarm 3D printing and assembly (SPA) platform as a model for future smart factories, consisting of thousands of IoT-based mobile robots performing different manufacturing operations with different end effectors (e.g., material deposition, energy deposition, pick and place, removal of materials, screw driving, etc.) and real-time monitoring. The swarm manufacturing platform transforms a 1-D factory into a 2-D factory with manufacturing robots that can move across the 2-D factory floor, work cooperatively with each other on the same production jobs, and re-configure in real-time (i.e., the manufacturing robots can be digitally controlled to move, re-group, calibrate, and work on a new job in real-time). |
| FILED | Thursday, February 11, 2021 |
| APPL NO | 17/798877 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/0009 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/171 (20170801) B29C 64/227 (20170801) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 30/00 (20141201) Systems for Controlling or Regulating Non-electric Variables G05D 1/0261 (20130101) G05D 1/0297 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230120968 | Abu-Ghazaleh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for the State University of New York (Binghamton, New York) |
| ASSIGNEE(S) | The Research Foundation for the State University of New York (Binghamton, New York) |
| INVENTOR(S) | Nael Abu-Ghazaleh (Vestal, New York); Weishuai Yang (Ozone Park, New York); Michael Lewis (Vestal, New York) |
| ABSTRACT | A cluster of nodes, comprising: a plurality of nodes, each having a security policy, and being associated task processing resources; a registration agent configured to register a node and issue a node certificate to the respective node; a communication network configured to communicate certificates to authorize access to computing resources, in accordance with the respective security policy; and a processor configured to automatically dynamically partition the plurality of nodes into subnets, based on at least a distance function of at least one node characteristic, each subnet designating a communication node for communicating control information and task data with other communication nodes, and to communicate control information between each node within the subnet and the communication node of the other subnets. |
| FILED | Wednesday, October 05, 2022 |
| APPL NO | 17/960251 |
| CURRENT CPC | Electric Digital Data Processing G06F 15/16 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 41/12 (20130101) H04L 43/10 (20130101) H04L 47/70 (20130101) H04L 67/02 (20130101) H04L 67/10 (20130101) H04L 67/51 (20220501) H04L 67/1044 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230121082 | Hsu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ku-Lung Hsu (Charlottesville, Virginia); Rebecca L. McCloud (Charlottesville, Virginia) |
| ABSTRACT | The present disclosure provides azetidine compounds of Formula I and their pharmaceutically acceptable salts, their compositions, and methods for their use in determining azetidine compound binding to proteins. The azetidine compounds are useful as probes, for monitoring diacylglycerol kinase activity, and for identifying druggable targets. |
| FILED | Wednesday, October 12, 2022 |
| APPL NO | 18/046070 |
| CURRENT CPC | Heterocyclic Compounds C07D 205/04 (20130101) C07D 205/12 (20130101) C07D 401/12 (20130101) C07D 403/04 (20130101) Original (OR) Class C07D 413/04 (20130101) C07D 417/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230121170 | Goldfarbmuren et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rebound Technologies, Inc. (Commerce City, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Russell Goldfarbmuren (Denver, Colorado); Luke Erickson (Denver, Colorado); Josh Nelson (West Lafayette, Indiana); Chance Lord (Denver, Colorado) |
| ABSTRACT | Solid production systems, devices, and methods utilizing oleophilic surfaces are provided in accordance with various embodiments. Some embodiments include a water tank used to store fresh water. Some embodiments include an emulsion tank that may include a set of auxiliary components that may be utilized to create and/or to pump an emulsion. This auxiliary equipment may include suction headers, ejectors, pumps, mechanical mixers, and/or hydrodynamic mixers, for example. Some embodiments include a heat exchanger that may produce a cold surface for ice formation. This surface may include an oleophilic surface that may produce an affinity for oils and/or other non-polar materials. Some embodiments include piping that may allow for the connection of the other components such that ice may be formed from a flow of water from the emulsion and the overflow may be returned to the emulsion tank. Ice making methods are also provided. |
| FILED | Monday, September 12, 2022 |
| APPL NO | 17/942297 |
| CURRENT CPC | Producing, Working or Handling Ice F25C 1/04 (20130101) F25C 1/12 (20130101) Original (OR) Class F25C 5/187 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230121352 | Reiserer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ronald S. Reiserer (Nashville, Tennessee); Gregory B. Gerken (Nashville, Tennessee); David K. Schaffer (Nashville, Tennessee); John P. Wikswo (Brentwood, Tennessee) |
| ABSTRACT | A fluidic cartridge comprises a fluidic disk having a plurality of alignment openings; a fluidic chip comprising a body, one or more channels formed in the body in fluidic communications with input ports and output ports for transferring one or more fluids between the input ports and the output ports, and a plurality of protrusions formed on the body and received in the alignment openings of the fluidic disk for aligning the fluidic chip to the fluidic disk; an actuator operably engaging with the one or more channels for selectively and individually transferring the one or more fluids through the one or more channels from at least one of the input ports to at least one of the output ports at desired flow rates; and a tube member defining a cylindrical housing for accommodating the fluidic disk, the fluidic chip and the actuator therein. |
| FILED | Wednesday, November 09, 2022 |
| APPL NO | 17/984151 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/08 (20130101) C12M 23/10 (20130101) C12M 23/12 (20130101) C12M 23/16 (20130101) C12M 23/50 (20130101) C12M 23/58 (20130101) C12M 27/02 (20130101) C12M 27/12 (20130101) C12M 29/10 (20130101) Original (OR) Class C12M 35/02 (20130101) C12M 35/04 (20130101) C12M 41/48 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230121423 | Makin, III et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of Western Michigan University (Kalamazoo, Michigan) |
| ASSIGNEE(S) | The Board of Trustees of Western Michigan University (Kalamazoo, Michigan) |
| INVENTOR(S) | Robert A. Makin, III (Kalamazoo, Michigan); Steven Michael Durbin (Kalamazoo, Michigan) |
| ABSTRACT | A method of fabricating a superconducting device includes determining a target transition temperature and utilizing a predefined quantitative relationship between superconducting transition temperature and an order parameter for at least one superconducting material composition is utilized to select a superconductor material composition that is capable of providing a target transition temperature. Process parameters may be controlled to form a superconductor device comprising at least one superconductor material having a material composition providing the target transition temperature. |
| FILED | Tuesday, November 29, 2022 |
| APPL NO | 18/070765 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 22/14 (20130101) H01L 29/66893 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230121727 | Aukes et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Daniel Aukes (Gilbert, Arizona); Mohammad Sharifzadeh (Phoenix, Arizona); Yuhao Jiang (Tempe, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Aukes (Gilbert, Arizona); Mohammad Sharifzadeh (Phoenix, Arizona); Yuhao Jiang (Tempe, Arizona) |
| ABSTRACT | A mechanical system includes a curved beam and a motor coupled to the curved beam. The curved beam is configured to buckle at two different locations along the positive and negative portions of its load/displacement curve, corresponding to opposite and equal sense bending directions. The motor is configured to impart a flapping motion to the curved beam. |
| FILED | Friday, October 14, 2022 |
| APPL NO | 17/966550 |
| CURRENT CPC | Vehicles for Use Both on Rail and on Road; Amphibious or Like Vehicles; Convertible Vehicles B60F 3/003 (20130101) B60F 5/02 (20130101) Original (OR) Class Marine Propulsion or Steering B63H 1/32 (20130101) Aeroplanes; Helicopters B64C 33/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230122977 | Jabbari |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of South Carolina (Columbia, South Carolina) |
| ASSIGNEE(S) | University of South Carolina (Columbia, South Carolina) |
| INVENTOR(S) | Esmaiel Jabbari (Bethesda, Maryland) |
| ABSTRACT | Described herein are regenerative approaches with tunable cell-cell and cell-matrix interactions to enhance the ability to regenerate multiple zones within a construct with each zone possessing a unique, optimum, level of cell-cell and cell-matrix interaction. |
| FILED | Thursday, March 10, 2022 |
| APPL NO | 17/691262 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/51 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/38 (20130101) A61L 27/54 (20130101) A61L 27/56 (20130101) A61L 27/227 (20130101) A61L 27/3612 (20130101) Original (OR) Class A61L 2101/46 (20200801) A61L 2400/12 (20130101) A61L 2400/18 (20130101) A61L 2430/10 (20130101) A61L 2430/20 (20130101) A61L 2430/26 (20130101) A61L 2430/32 (20130101) A61L 2430/34 (20130101) A61L 2430/40 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0607 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230123400 | Beaumont |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jacques Beaumont (Liverpool, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jacques Beaumont (Liverpool, New York) |
| ABSTRACT | A method for time constant estimation includes generating a bound for a R=1/ |
| FILED | Monday, November 28, 2022 |
| APPL NO | 17/994575 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/002 (20130101) G01N 33/48728 (20130101) Original (OR) Class Electric Digital Data Processing G06F 17/13 (20130101) Computer Systems Based on Specific Computational Models G06N 7/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230123862 | Fok et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Georgia Research Foundation, Inc. (Athens, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mable P. Fok (Bishop, Georgia); Qidi Liu (Athens, Georgia) |
| ABSTRACT | Various examples are provided related to adaptive photonic radio frequency (RF) spectral shapers. In one example, a RF spectral shaper includes processing circuitry that can generate finite impulse response (FIR) parameters based upon a target RF spectral response; an optical wave shaper that can generate a shaped interleaved comb carrier from a broadband optical signal based upon the FIR parameters; an electro-optic modulator (EOM) that can modulate an RF signal onto the shaped interleaved comb carrier to generate a modulated optical comb carrier; and a photodetector that can convert the modulated optical comb carrier back to an RF output signal. In another example, a method includes generating FIR parameters based upon a target RF spectral response; generating a shaped interleaved comb carrier from a broadband optical signal based upon the FIR parameters; and generating a modulated optical comb carrier by modulating an RF signal onto the shaped interleaved comb carrier. |
| FILED | Saturday, March 06, 2021 |
| APPL NO | 17/909574 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/0115 (20130101) G02F 1/0123 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230124039 | McCormick et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jackson McCormick (Atlanta, Georgia); Morris Cohen (Atlanta, Georgia) |
| ABSTRACT | An embodiment of the disclosure provides a method of generating an electron density map of a D-region of the ionsphere. The method can comprise: defining a plurality of grid pixels corresponding to a portion of the D-region of the ionosphere; receiving a plurality of electromagnetic signals, each of the plurality of electromagnetic signals having propagated along a distinct propagation path through a portion of the D-region corresponding to one or more of the plurality of grid pixels; clustering the plurality of electromagnetic signals based on similarities in a point-of-origin of the plurality of electromagnetic signals; determining a path-averaged electron density curve for each of the plurality of clustered signals; determining a basis representation of an electron density curve of the plurality of grid pixels, which is consistent with the path-averaged electron density curves; and generating, based on the as is representation, an electron density map for the D-region of the ionosphere. |
| FILED | Monday, December 21, 2020 |
| APPL NO | 17/786603 |
| CURRENT CPC | Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags G01V 9/007 (20130101) Transmission H04B 7/22 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230124554 | Jiang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Shaoyi Jiang (Redmond, Washington); Tao Bai (Seattle, Washington); Jean-René Ella-Menye (Seattle, Washington); Hsiang-Chieh Hung (Seattle, Washington); Priyesh Jain (Seattle, Washington); Andrew Sinclair (Seattle, Washington); Harihara Subramanian Sundaram (Seattle, Washington); Yang Li (Seattle, Washington); Peng Zhang (Seattle, Washington) |
| ABSTRACT | Free-standing non-fouling polymers and polymeric compositions, monomers and macromonomers for making the polymers and polymeric compositions, objects made from the polymers and polymeric compositions, and methods for making and using the polymers and polymeric compositions |
| FILED | Monday, November 28, 2022 |
| APPL NO | 18/059104 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/58 (20170801) A61K 47/59 (20170801) A61K 47/593 (20170801) A61K 47/595 (20170801) Acyclic or Carbocyclic Compounds C07C 229/12 (20130101) C07C 229/16 (20130101) C07C 237/22 (20130101) C07C 253/30 (20130101) C07C 255/23 (20130101) C07C 255/26 (20130101) C07C 265/04 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/091 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 220/34 (20130101) Original (OR) Class C08F 220/36 (20130101) C08F 220/42 (20130101) C08F 220/44 (20130101) C08F 220/48 (20130101) C08F 220/50 (20130101) C08F 220/603 (20200201) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/78 (20130101) C08G 18/3821 (20130101) C08G 61/06 (20130101) C08G 61/08 (20130101) C08G 61/12 (20130101) C08G 63/6856 (20130101) C08G 69/26 (20130101) C08G 69/42 (20130101) C08G 73/0206 (20130101) C08G 73/0226 (20130101) C08G 73/0233 (20130101) C08G 73/0611 (20130101) Compositions of Macromolecular Compounds C08L 35/02 (20130101) C08L 65/00 (20130101) C08L 67/02 (20130101) C08L 75/04 (20130101) C08L 77/06 (20130101) C08L 79/02 (20130101) C08L 79/04 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/1637 (20130101) C09D 5/1662 (20130101) C09D 7/65 (20180101) C09D 135/02 (20130101) C09D 165/00 (20130101) C09D 167/02 (20130101) C09D 175/04 (20130101) C09D 177/06 (20130101) C09D 179/02 (20130101) C09D 179/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230124695 | Avval et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Little Rock, Arkansas) |
| ASSIGNEE(S) | BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Little Rock, Arkansas) |
| INVENTOR(S) | Amirreza Ghadimi Avval (Fayetteville, Arkansas); Samir El-Ghazaly (Fayetteville, Arkansas) |
| ABSTRACT | A transistor using patterned metamaterial electrode manipulating electromagnetic waves to achieve matched phase velocity on the input and output ports. A design method is taught wherein the layout of the electrodes can be designed to compensate for the phase-velocity mismatch induced by the transistor's intrinsic properties. |
| FILED | Tuesday, March 09, 2021 |
| APPL NO | 17/910782 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/2011 (20130101) Original (OR) Class H01L 29/205 (20130101) H01L 29/2003 (20130101) H01L 29/42316 (20130101) H01L 29/66462 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20230117122 | Minsky et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Milan Minsky (Newton, Massachusetts); Julie Fouquet (Portola Valley, California); Iosif Izrailit (Newton, Massachusetts); Rei Landsberger (Santa Barbara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Milan Minsky (Newton, Massachusetts); Julie Fouquet (Portola Valley, California); Iosif Izrailit (Newton, Massachusetts); Rei Landsberger (Santa Barbara, California) |
| ABSTRACT | A biofilm inhibition system, for a sensor which includes a chamber with an interior volume and an interior surface exposed to direct contact with a fluid during sensor operation, includes an ultraviolet light emitting diode (UV-LED) and an optical subsystem. The optical subsystem is coupled to the UV-LED to deliver a portion of the emitted UV light to illuminate a substantial fraction of the interior volume and the interior surface. A watertight housing encloses the UV-LED and at least a portion of the optical subsystem. |
| FILED | Thursday, October 13, 2022 |
| APPL NO | 17/965126 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 2/10 (20130101) Original (OR) Class A61L 2/28 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/325 (20130101) C02F 2103/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230117171 | Bao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Zhenan Bao (Stanford, California); Yi Cui (Stanford, California); Zhiao Yu (Stanford, California); Snehashis Choudhury (Stanford, California); Hansen Wang (Stanford, California) |
| ABSTRACT | Provided herein are solvents for an electrolyte of a battery comprising fluorinated compounds of the present disclosure, batteries comprising: an anode structure including an anode current collector; a cathode structure including a cathode current collector and a cathode material disposed on the cathode current collector; and the electrolyte of the disclosure. Also provided herein are layers of a battery, comprising a fluorinated polymer compounds of the present disclosure. |
| FILED | Friday, August 28, 2020 |
| APPL NO | 17/773578 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0525 (20130101) H01M 10/0565 (20130101) H01M 10/0569 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230117348 | Timpson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| INVENTOR(S) | Erik J. Timpson (Lee's Summit, Missouri); George W. Bohnert (Harrisonville, Missouri) |
| ABSTRACT | A battery and cooling device system comprising a thermal battery and a cooling device including a boiler, a condenser, a vapor tube, a reaction container, and a siphon. The boiler boils a solvent via heat drawn from the battery. The condenser condenses the vaporized solvent. The vapor tube connects the boiler to the reaction container so that the vaporized solvent travels through the vapor tube from the boiler into the condenser. The reaction container receives the liquidated solvent from the condenser so that the liquidated solvent interacts with a solute in the reaction container to effect an endothermic reaction to further draw heat from the battery. The siphon connects the reaction container to the boiler and drains the liquid solvent from the reaction container into the boiler once a predetermined amount of liquid solvent fills the reaction container. |
| FILED | Friday, October 15, 2021 |
| APPL NO | 17/502211 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/613 (20150401) H01M 10/6568 (20150401) H01M 10/6569 (20150401) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230117506 | Harrison et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew S. Harrison (Oak Ridge, Tennessee); Anthony D. McBee (Oak Ridge, Tennessee); Darren D. Loposser (Oak Ridge, Tennessee); Michael E. Bowling (Oak Ridge, Tennessee); Nikolas J. Smith (Oak Ridge, Tennessee) |
| ABSTRACT | A system for redundantly detecting a gas is provided. The system includes first and second series-connected gas sensors and a signaling module. If both gas sensors are functioning normally, the signaling module provides an alert when both gas sensors detect a predetermined gas concentration. If however any one of the gas sensors is experiencing a fault condition, the faulty gas sensor's alarm is shunted by operation of a fault relay, and the signaling module provides an alert when the non-faulty gas sensor detects a predetermined gas concentration. If both gas sensors are experiencing a fault condition, both gas sensors' alarms are shunted by fault relays, and an audible and/or visual alert is generated by the signaling module. Embodiments of the present invention are well suited for industrial facilities, manufacturing facilities, research and development laboratories, and other locations where unsafe gas concentrations may become present. |
| FILED | Thursday, October 06, 2022 |
| APPL NO | 17/960886 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/0031 (20130101) Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 21/14 (20130101) Original (OR) Class G08B 29/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230119263 | Lim et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hyungyu Lim (San Diego, California); Thomas T. Eng (El Cerrito, California); Adam M. Feist (San Diego, California) |
| ABSTRACT | The present invention provides for a Pseudomonas cell is able to grow in a medium with xylose or galactose as a sole carbon source with a growth rate of equal to or higher than 0.10 h−1. The present invention provides for methods and compositions relating to an engineered Pseudomonas putida KT2440 utilizing a non-native carbon source, such as galactose or xylose or both. |
| FILED | Wednesday, March 30, 2022 |
| APPL NO | 17/709332 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) Original (OR) Class C12N 9/88 (20130101) C12N 9/90 (20130101) C12N 9/1205 (20130101) C12N 9/1241 (20130101) C12N 15/52 (20130101) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/40 (20210501) Enzymes C12Y 207/01006 (20130101) C12Y 207/07012 (20130101) C12Y 402/01082 (20130101) C12Y 501/03002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230120088 | SANT et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); CarbonBuilt (Manhattan Beach, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gaurav SANT (Los Angeles, California); Dante SIMONETTI (Los Angeles, California); Iman MEHDIPOUR (Los Angeles, California); David JASSBY (Los Angeles, California); Yenwen TSENG (Los Angeles, California) |
| ABSTRACT | A method of forming a concrete product includes directly capturing CO2 from a gas source, the capturing comprising contacting the gas source with an absorption solution having a solvent and a solute, wherein the solvent and/or the solute are capable of reacting with CO2 to form an anionic compound, adjusting the pH of the absorption solution electrochemically to less than about 7 to release the CO2 as a concentrated vapor containing CO2, collecting the concentrated vapor containing CO2, regenerating the solvent and/or the solute, and optionally collecting the regenerated solvent and/or solute; flowing the concentrated vapor containing CO2 through a gas processing unit to adjust at least one of a temperature, a relative humidity, or a flow rate of the concentrated vapor containing CO2; and contacting the concentrated vapor containing CO2 with a concrete component. |
| FILED | Tuesday, October 18, 2022 |
| APPL NO | 18/047633 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 40/0007 (20130101) C04B 40/0231 (20130101) Original (OR) Class C04B 2111/00017 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230120127 | PALMSTROM et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado); Swift Solar, Inc. (San Carlos, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Axel Finn PALMSTROM (Golden, Colorado); Tomas LEIJTENS (Emerald Hills, California); Joseph Jonathan BERRY (Boulder, Colorado); David Todd MOORE (Arvada, Colorado); Giles Edward EPERON (Arvada, Colorado) |
| ABSTRACT | The present disclosure relates to a device that includes a first layer that includes at least one of a semiconducting material, a hole transport material (HTM), and/or an electron transport material (ETM), a second layer, and a third layer that includes a material that is at least one of transparent or conductive, where the second layer is positioned between the first layer and the third layer, the first layer, the second layer, and the third layer are in electrical contact with each other, and the third layer has a first thickness between greater than zero nm and about 100 nm. In some embodiments of the present disclosure, the semiconducting material may include a perovskite. |
| FILED | Thursday, December 15, 2022 |
| APPL NO | 18/066628 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0037 (20130101) H01L 51/0043 (20130101) Original (OR) Class H01L 51/0046 (20130101) H01L 51/422 (20130101) H01L 51/4253 (20130101) H01L 2251/303 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230120926 | Thomas et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Coreform LLC (Orem, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Derek C. Thomas (Orem, Utah); Michael A. Scott (American Fork, Utah) |
| ABSTRACT | U-splines are a novel approach to the construction of a spline basis for representing smooth objects in Computer-Aided Design (CAD) and Computer-Aided Engineering (CAE). A spline is a piecewise-defined function that satisfies continuity constraints between adjacent cells in a mesh. U-splines differ from existing spline constructions, such as Non-Uniform Rational B-splines (NURBS), subdivision surfaces, T-splines, and hierarchical B-splines, in that they can accommodate local variation in cell size, polynomial degree, and smoothness simultaneously over more varied mesh configurations. Mixed cell types (e.g., triangle and tetrahedron and quadrilateral and hexahedral cells in the same mesh) and T-junctions are also supported. The U-spline construction is presented for curves, surfaces, and volumes with higher dimensional generalizations possible. A set of requirements are given to ensure that the U-spline basis is positive, forms a partition of unity, is complete, and is locally linearly independent. |
| FILED | Friday, April 01, 2022 |
| APPL NO | 17/711874 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/12 (20200101) Original (OR) Class G06F 30/23 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230121080 | Chapin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California); the United States of America as represented by the Secretary of the Army (Huntsville, Alabama); BAE Systems Land and Armaments L.P. (Sterling Heights, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Caitlin Anne Chapin (Fremont, California); Lars F. Voss (Livermore, California); Luis M. Hernandez (Coon Rapids, Minnesota); Mark Rader (Decatur, Alabama) |
| ABSTRACT | In one general embodiment, a structure includes a first diode, comprising: a first layer having a first type of dopant, and a second layer above the first layer, the second layer having a second type of dopant that is opposite to the first type of dopant. A second diode is formed directly on the first diode. The second diode comprises a first layer having a third type of dopant and a second layer above the first layer of the second diode, the second layer of the second diode having a fourth type of dopant that is opposite to the third type of dopant. In another general embodiment, a process includes a repeated sequence of growing a first layer having a first type of electrically active dopant and growing a second layer having a second type of electrically active dopant that is opposite to the first type of dopant. |
| FILED | Monday, October 17, 2022 |
| APPL NO | 17/967754 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/866 (20130101) Original (OR) Class H01L 29/66151 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230121100 | Compton et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Tennessee Research Foundation (Knoxville, Tennessee) |
| ASSIGNEE(S) | University of Tennessee Research Foundation (Knoxville, None) |
| INVENTOR(S) | Brett Gibson Compton (Knoxville, None); James William Kemp (Dayton, None); Stian Kristov Romberg (Maryville, Tennessee); Jesse Lynn Reed (Clinton, Tennessee) |
| ABSTRACT | Compositions comprising preceramic resins and fumed alumina are described. The compositions can also include fillers, such as silicon carbide whiskers or zirconium diboride particles. The compositions can be used as three-dimensional printable inks for preparing ceramic composites, e.g., composites having complex geometry. Inclusion of fumed alumina as a rheology modifier in the composition can provide improved printing properties for the inks compared to preceramic resin inks that do not include fumed alumina. |
| FILED | Monday, October 17, 2022 |
| APPL NO | 17/967634 |
| CURRENT CPC | Shaping Clay or Other Ceramic Compositions; Shaping Slag; Shaping Mixtures Containing Cementitious Material, e.g Plaster B28B 1/001 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/78 (20130101) C04B 35/571 (20130101) Original (OR) Class C04B 2235/483 (20130101) C04B 2235/524 (20130101) C04B 2235/3217 (20130101) C04B 2235/3813 (20130101) C04B 2235/3826 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230121266 | McIntyre et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Energy, United States Department of (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dustin Langdon McIntyre (Washington, Pennsylvania); Daniel Allen Hartzler (Westover, West Virginia) |
| ABSTRACT | An actively Q-switched laser induced breakdown spectroscopy (LIBS) probe, utilizing an optical fiber, a pump beam transmitted through the optical fiber, a coupler, and a lens for collimating the pump beam. The actively Q-switched laser, coupled to a sensor which provides information to a computer that controls a high voltage pulser providing a pulse to a Pockels cell located within the laser which can selectively cause the laser to pulse, resulting in high energy pulses and a second lens for focusing the output pulse such that it creates a plasma or spark. The light from the spark is captured and directed back through an optical system to remote equipment for elemental and/or molecular analysis. |
| FILED | Tuesday, October 19, 2021 |
| APPL NO | 17/504619 |
| CURRENT CPC | Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/0624 (20151001) Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/0208 (20130101) G01J 3/0218 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/718 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230121883 | DHARMASENA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GM GLOBAL TECHNOLOGY OPERATIONS LLC (Detroit, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ruchira DHARMASENA (Shelby Township, Michigan); Shuru Chen (Troy, Michigan); Fang Dai (Troy, Michigan); Mei Cai (Bloomfield Hills, Michigan); Sanaz Ketabi (Holt, Michigan) |
| ABSTRACT | A system for coating a separator for a battery includes a separator feed and collection assembly configured to dispense the separator, a coating distribution device configured to flow a coating material toward the separator, and an electric field generator configured to generate an electric field in a gap between the coating distribution device and the separator. |
| FILED | Wednesday, October 20, 2021 |
| APPL NO | 17/506446 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0404 (20130101) Original (OR) Class H01M 10/0525 (20130101) H01M 50/431 (20210101) H01M 50/446 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230121991 | Young et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell Federal Manufacturing & Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | Honeywell Federal Manufacturing & Technologies, LLC (Kansas City, Missouri) |
| INVENTOR(S) | Barbara Diane Young (Raymore, Missouri); Steven James Sedlock (Raymore, Missouri); Kevin Christopher Ledden (Raymore, Missouri); Alan Ahlberg Elliot (Lee's Summit, Missouri) |
| ABSTRACT | A multichip module comprises a carrier, a plurality of chips, an electrical insulating layer, and an electrical interconnect structure. The carrier includes a bottom wall and four side walls defining an internal cavity. The chips are positioned in the internal cavity, with each chip including a plurality of bond pads. The electrical insulating layer is formed from electrically insulating material and is positioned on an upper surface of the carrier and the chips. The electrical interconnect structure includes a plurality of interconnect traces, with each interconnect trace formed from electrically conductive material and electrically connected to a first bond pad on a first chip and a second bond pad on a second chip. Each interconnect trace includes a bridge having a segment that is spaced apart from, and positioned above, the electrical insulating layer. |
| FILED | Thursday, October 14, 2021 |
| APPL NO | 17/501043 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 24/06 (20130101) H01L 24/24 (20130101) H01L 24/25 (20130101) H01L 24/82 (20130101) Original (OR) Class H01L 25/0655 (20130101) H01L 2224/2405 (20130101) H01L 2224/06165 (20130101) H01L 2224/24011 (20130101) H01L 2224/24101 (20130101) H01L 2224/24137 (20130101) H01L 2224/25175 (20130101) H01L 2224/82002 (20130101) H01L 2224/82101 (20130101) H01L 2224/82106 (20130101) H01L 2224/82986 (20130101) H01L 2924/3512 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230122594 | Reiserer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ronald S. Reiserer (Nashville, Tennessee); David K. Schaffer (Nashville, Tennessee); Philip C. Samson (Nashville, Tennessee); Dmitry A. Markov (Nashville, Tennessee); Michael Geuy (Nashville, Tennessee); Lisa J. McCawley (Nashville, Tennessee); John P. Wikswo (Brentwood, Tennessee) |
| ABSTRACT | Microfluidic systems, pumps, valves and applications of the same are provided. The microfluidic system may be a pump or a valve having a fluidic chip and an actuator controlling the opening and closing of the fluidic channel in the fluidic chip. The actuator may be disposed to tilt from the fluidic chip, forming a tilted-rotor peristaltic pump. Alternatively, the actuator may be a rolling ball actuator, and different fluidic chips may be used in different applications. For example, the fluidic chip may be a spiral pump chip having spiral channels, a rotary peristaltic pump chip having multiple output channels, or a multi-port valve chip having one port interconnected with multiple different ports. An analytical valve chip may switchably interconnect bioreactor and rinse/calibration input channels to sensor and waste output channels. The actuator of a random-access valve can move from one valve position to another without opening or closing intermediate ones. |
| FILED | Tuesday, December 20, 2022 |
| APPL NO | 18/084634 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502738 (20130101) Original (OR) Class B01L 2300/123 (20130101) B01L 2300/0627 (20130101) B01L 2400/0644 (20130101) Positive-displacement Machines for Liquids; Pumps F04B 43/1261 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230122822 | Vaid |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas Vaid (Ann Arbor, Michigan) |
| ABSTRACT | A redox matched flow battery utilizes insoluble functionalized catholyte and anolyte beads to store charge on redox-active moieties tethered to the beads, with charge being transferred between the electrodes and the bead using a soluble, redox-matched mediator. |
| FILED | Friday, October 07, 2022 |
| APPL NO | 17/961831 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/18 (20130101) Original (OR) Class H01M 8/023 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230123528 | EL-DASHER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (LIVERMORE, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bassem S. EL-DASHER (Livermore, California); Andrew J. BAYRAMIAN (Marblehead, Massachusetts); James A. DEMUTH (Woburn, Massachusetts); Joseph C. FARMER (Tracy, California); Sharon G. TORRES (Livermore, California) |
| ABSTRACT | The present disclosure relates to a system for performing an Additive Manufacturing (AM) fabrication process on a powdered material, deposited as a powder bed and forming a substrate. The system makes use of a laser for generating a laser beam, and an optical subsystem. The optical subsystem is configured to receive the laser beam and to generate an optical signal comprised of electromagnetic radiation sufficient to melt or sinter the powdered material. The optical subsystem uses a digitally controlled mask configured to pattern the optical signal as needed to melt select portions of a layer of the powdered material to form a layer of a 3D part. A power supply and at least one processor are also included for generating a plurality of different power density levels selectable based on a specific material composition, absorptivity and diameter of the powder particles, and a known thickness of the powder bed. The powdered material is used to form the 3D part in a sequential layer-by-layer process. |
| FILED | Thursday, October 20, 2022 |
| APPL NO | 17/969741 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/20 (20210101) B22F 10/30 (20210101) Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/042 (20151001) B23K 26/066 (20151001) B23K 26/144 (20151001) B23K 26/342 (20151001) Original (OR) Class B23K 26/0622 (20151001) B23K 26/0643 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/153 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 30/00 (20141201) B33Y 80/00 (20141201) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 10/25 (20151101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230123536 | Candy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Christopher Roland Candy (San Ramon, California); Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Vincent Candy (Danville, California); Karl Albert Fisher (Brentwood, Canada); Christopher Roland Candy (San Ramon, California) |
| ABSTRACT | An event detection unit (EDU) for detecting an explosive event is provided. The EDU includes different types of sensors for measuring characteristics of an explosive event. The EDU includes an event notification component. The EDU also includes a processor that receives a measurement from the sensors and generates a combined non-event probability and a combined event probability based on that measurement that indicates a likelihood that an explosive event has not occurred or has occurred. The processor determines whether an explosive event has occurred based on the non-event probabilities and event probabilities. When an explosive event has been determined to occur, the processor directs the event notification component to output a notification that an explosive event has occurred. |
| FILED | Wednesday, November 30, 2022 |
| APPL NO | 18/072373 |
| CURRENT CPC | Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 3/10 (20130101) G08B 5/36 (20130101) G08B 17/08 (20130101) Original (OR) Class G08B 29/185 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230123612 | Negi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NMC, INC. (Los Alamos, New Mexico); LOS ALAMOS NATIONAL SECURITY, LLC (Los Alamos, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sangeeta Negi (Los Alamos, New Mexico); Richard Thomas Sayre (Los Alamos, New Mexico); Shawn Robert Starkenburg (Los Alamos, New Mexico) |
| ABSTRACT | Phototropin is a blue light receptor, which mediates a variety of blue-light elicited physiological processes in plants and algae. In higher plants these processes include phototropism, chloroplast movement and stomatal opening. In the green alga Chlamydomonas reinhardtii, phototropin plays a vital role in progression of the sexual life cycle and in the control of the eye spot size and light sensitivity Phototropin is also involved in blue-light mediated changes in the synthesis of chlorophylls, carotenoids, chlorophyll binding proteins. We compared the transcriptome of phototropin knock out (PHOT KO) mutant and wild-type parent to analyze differences in gene expression in high light grown cultures (500 µmol photons m-2s-1). Our results indicate the up-regulation of genes involved in photosynthetic electron transport chain, carbon fixation pathway, starch, lipid, and cell cycle control genes. With respect to photosynthetic electron transport genes, genes encoding proteins of the cytochrome b6f and ATP synthase complex were up regulated potentially facilitating proton-coupled electron transfer. In addition genes involved in limiting steps in the Calvin cycle Ribulose-1 ,5-bisphosphate carboxylase/oxygenase (RuBisCO), Sidoheptulose 1,7 bisphosphatase (SBPase), Glyceraldehyde-3-phosphate dehydrogenase (3PGDH) and that mediate cell-cycle control (CDK) were also up regulated along with starch synthase and fatty acid biosynthesis genes involved in starch and lipid synthesis. In addition, transmission electron micrographs show increased accumulation of starch granules in PHOT mutant compared to wild type, which is consistent with the higher expression of starch synthase genes. Collectively, the altered patterns of gene expression in the PHOT mutants were associated with a two-fold increase in growth and biomass accumulation compared to wild type when grown in environmental photobioreactors (Phenometrics) that simulate a pond environment. In conclusion, our studies suggest that phototropin may be a master gene regulator that suppresses rapid cell growth and promotes gametogenesis and sexual recombination in wild type strains. |
| FILED | Wednesday, February 23, 2022 |
| APPL NO | 17/678834 |
| CURRENT CPC | Peptides C07K 14/405 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/12 (20130101) C12N 9/12 (20130101) Original (OR) Class C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230124115 | KEASLING et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jay D. KEASLING (Emeryville, California); Amin ZARGAR (Emeryville, California) |
| ABSTRACT | Polyketide synthases are engineered to produce lactones. In the first module, an acyltransferase is swapped and in the second module a reductive loop is swapped. With another acyltransferase swap in the second module, we can programmably produce the non-methylated delta lactone. |
| FILED | Monday, November 07, 2022 |
| APPL NO | 18/053288 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/93 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/62 (20130101) Original (OR) Class Enzymes C12Y 604/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230124711 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xin Chen (Los Angeles, California); Erika Callagon La Plante (Los Angeles, California); Gaurav Sant (Los Angeles, California); David Jassby (Los Angeles, California); Dante Adam Simonetti (Los Angeles, California); Shengcun Ma (Los Angeles, California) |
| ABSTRACT | A method for producing one or more hydroxide solids includes providing a catholyte comprising an electrolyte solution; contacting the catholyte with an electroactive mesh cathode to electrolytically generate hydroxide ions, thereby precipitating the one or more hydroxide solid(s); and removing the one or more hydroxide solids from the surface of the mesh where they may deposit. |
| FILED | Tuesday, October 18, 2022 |
| APPL NO | 17/968596 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/20 (20130101) Original (OR) Class C25B 9/19 (20210101) C25B 9/30 (20210101) C25B 11/03 (20130101) C25B 11/046 (20210101) C25B 13/08 (20130101) C25B 15/081 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230125056 | Lalam et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Department of Energy (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nageswara Rao Lalam (Pittsburgh, Pennsylvania); Michael P. Buric (Fairview, West Virginia); Ping Lu (West Hartford, Connecticut); Fei Lu (Lubbock, Texas); Tao Hong (Xi'an, China PRC); Ruishu Feng Wright (Pittsburgh, Pennsylvania) |
| ABSTRACT | One or more embodiments relates to a system for simultaneously detecting vibration and the presence of a target gas having a tunable fiber ring laser in electronic and optical communication with a vibration sensor and a gas detection sensor. One or more embodiments relate to a method for simultaneously measuring vibration and detecting the presence of a target gas in an environment having the steps of providing a system for simultaneously measuring vibration and detecting a target gas into an environment; sending an optical signal to a vibration sensor and gas detection sensor; and collecting and analyzing modified signals from the vibration sensor and gas detection sensor. |
| FILED | Monday, October 17, 2022 |
| APPL NO | 17/967025 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/39 (20130101) Original (OR) Class G01N 33/0036 (20130101) G01N 2021/458 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/06791 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20230120408 | Kim et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Changsub Kim (Pasadena, California); Daniel P. Cunnane (Pasadena, California) |
| ABSTRACT | A method of making a film comprising depositing magnesium and boron on a substrate; depositing a capping layer to form a capped film; and cooling the capped film so as to form a magnesium diboride film. The depositing may comprise tuning a ratio of the Mg to the B so as to tailor a resistivity of the magnesium diboride film anywhere in the range 10 μΩ*cm≤ρ≤500 mΩ*cm, and so as to form the magnesium diboride film comprising a superconductive film having a critical temperature greater than 10K or in a range 10K-40K. The magnesium diboride film can have an area greater than or equal to a circular area having a diameter of at least 4 inches; a thickness and sheet resistance varying by less than 10% over an entirety of the area; and a surface roughness less than 2 nm over the entirety of the area. |
| FILED | Tuesday, October 18, 2022 |
| APPL NO | 17/968556 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 39/141 (20130101) Original (OR) Class H01L 39/2487 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230121027 | JOHNSON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael R. JOHNSON (Pasadena, California); Weibo CHEN (Pasadena, California); Andrew B. BERG, Jr. (Pasadena, California); Patrick DEGROSSE, Jr. (Pasadena, California); John Luke WOLFF (Pasadena, California); Evan W. HILGEMANN (Pasadena, California); Noah T. FOX (Pasadena, California) |
| ABSTRACT | Methods and devices for blending of fluids are disclosed. A fluid blender has a fluid inlet to receive a fluid, a nozzle with a convergent shape tapering down towards a nozzle end, a mixing chamber with holes arranged on a wall, and a mixture outlet having a divergent shape. In some aspects, a rotary sleeve is externally placed around the wall. The rotary sleeve has slits with a variable shape along its lateral extension. In other aspects the fluid blender has inlet tubes with check valves and a blending tube. An inlet tube has an adjustable orifice to adjust flow inside the blender. |
| FILED | Wednesday, March 31, 2021 |
| APPL NO | 17/905161 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 16/105 (20130101) A61M 16/127 (20140204) Original (OR) Class A61M 16/201 (20140204) A61M 16/209 (20140204) A61M 16/0833 (20140204) A61M 2202/0007 (20130101) A61M 2202/0208 (20130101) A61M 2205/42 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230121352 | Reiserer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ronald S. Reiserer (Nashville, Tennessee); Gregory B. Gerken (Nashville, Tennessee); David K. Schaffer (Nashville, Tennessee); John P. Wikswo (Brentwood, Tennessee) |
| ABSTRACT | A fluidic cartridge comprises a fluidic disk having a plurality of alignment openings; a fluidic chip comprising a body, one or more channels formed in the body in fluidic communications with input ports and output ports for transferring one or more fluids between the input ports and the output ports, and a plurality of protrusions formed on the body and received in the alignment openings of the fluidic disk for aligning the fluidic chip to the fluidic disk; an actuator operably engaging with the one or more channels for selectively and individually transferring the one or more fluids through the one or more channels from at least one of the input ports to at least one of the output ports at desired flow rates; and a tube member defining a cylindrical housing for accommodating the fluidic disk, the fluidic chip and the actuator therein. |
| FILED | Wednesday, November 09, 2022 |
| APPL NO | 17/984151 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/08 (20130101) C12M 23/10 (20130101) C12M 23/12 (20130101) C12M 23/16 (20130101) C12M 23/50 (20130101) C12M 23/58 (20130101) C12M 27/02 (20130101) C12M 27/12 (20130101) C12M 29/10 (20130101) Original (OR) Class C12M 35/02 (20130101) C12M 35/04 (20130101) C12M 41/48 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20230121487 — NANOCARBON COATING SYSTEM AND COATING METHOD FOR STRAY AND REFLECTED LIGHT SUPPRESSION
| US 20230121487 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Faraday Technology, Inc. (Englewood, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dan Wang (Dublin, Ohio); Timothy David Hall (Englewood, Ohio); Maria E. Inman (Yellow Springs, Ohio); Rajeswaran Radhakrishnan (Beavercreek, Ohio); Earl Jennings Taylor (Troy, Ohio) |
| ABSTRACT | A method of coating a substrate, the method comprises adding a nanocarbon material to an electrophoretic solution in an electrophoretic deposition apparatus including the substrate and an electrode spaced from the substrate, and applying a current to the substrate and the electrode to deposit the nanocarbon material onto the substrate. |
| FILED | Tuesday, September 27, 2022 |
| APPL NO | 17/953885 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 5/18 (20130101) C25D 9/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230122775 | JOHNSON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael R. JOHNSON (Pasadena, California); Mary M. EASTER (Pasadena, California); Patrick DEGROSSE, JR. (Pasadena, California); Brandon C. METZ (Pasadena, California); George C. RICHDALE, III (Pasadena, California); Ara KOURCHIANS (Pasadena, California); Havard F. GRIP (Pasadena, California); Noah T. FOX (Pasadena, California); John Luke WOLFF (Pasadena, California); Evan W. HILGEMANN (Pasadena, California); Arthur J. MASTROPIETRO (Pasadena, California); Razmig KANDILIAN (Pasadena, California); Daniel F. BERISFORD (Pasadena, California) |
| ABSTRACT | Ventilation methods and devices are disclosed. The described methods and devices can be used for treating respiratory diseases. More in particular, the teachings of the disclosure relate to methods and devices to treat victims of adult respiratory distress syndrome (ARDS). Embedded control software managing various functionalities of the disclosed ventilators is also presented. |
| FILED | Tuesday, March 30, 2021 |
| APPL NO | 17/905158 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 16/024 (20170801) A61M 16/125 (20140204) Original (OR) Class A61M 2202/0208 (20130101) A61M 2205/3334 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230123777 | Weisberger et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America as Represented by The Administrator of NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joshua M. Weisberger (Newport News, Virginia); Brett F. Bathel (Yorktown, Virginia) |
| ABSTRACT | A real-time reference free background oriented schlieren system is provided. One embodiment includes a display device capable of generating an image pattern projected onto a retroreflective background. A beam splitter is used to transmit a portion of the projected image pattern towards a reference image sensor and another portion of the image pattern towards the retroreflective background and past a density object. The retroreflective background reflects the projected pattern back through the beam splitter and onto a signal imaging sensor. Collected data from the reference image sensor and the signal image sensor may be processed in real-time. The image pattern may be altered as necessary without requiring a new reference image, reducing the amount of time required to set up and adjust the system. A display device may be capable of switching between a schlieren visualization capability to a shadowgraph system allowing for the use of two different imaging techniques. |
| FILED | Thursday, April 21, 2022 |
| APPL NO | 17/725693 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 11/2513 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/455 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20230119324 | Habib |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amyn Habib (Dallas, Texas) |
| ABSTRACT | The present disclosure is concerned with modulators of EGFR and modulators of IFN for treating various cancers such as, for example, sarcomas, carcinomas, hematological cancers, solid tumors, breast cancer, cervical cancer, gastrointestinal cancer, colorectal cancer, brain cancer, skin cancer, prostate cancer, ovarian cancer, bladder cancer, thyroid cancer, testicular cancer, pancreatic cancer, endometrial cancer, melanomas, gliomas, leukemias, lymphomas, chronic myeloproliferative disorders, myelodysplastic syndromes, myeloproliferative neoplasms, and plasma cell neoplasms (myelomas). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| FILED | Friday, February 19, 2021 |
| APPL NO | 17/800208 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/517 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2866 (20130101) C07K 2317/76 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230120005 | Ledet et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York) |
| ASSIGNEE(S) | RENSSELAER POLYTECHNIC INSTITUTE (TROY, New York) |
| INVENTOR(S) | Eric Howard Ledet (Schenectady, New York); Sydney Marie Caparaso (Monroe, Connecticut); Katerina Vladmirovna Kradinova (Boxborough, Massachusetts); Elizabeth Anne Capogna (Rexford, New York) |
| ABSTRACT | A force measuring apparatus is described. The apparatus includes a force concentrator. The force concentrator is configured to attach to a loadbearing medical device and to produce a transverse force related to an eccentric axial force applied to the loadbearing medical device. A bending stiffness of the force concentrator is different from a bending stiffness of the loadbearing medical device. |
| FILED | Monday, August 29, 2022 |
| APPL NO | 17/897349 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/64 (20130101) A61B 17/80 (20130101) A61B 17/7059 (20130101) A61B 17/8869 (20130101) A61B 90/06 (20160201) Original (OR) Class A61B 2090/064 (20160201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230121584 | Damaser et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE CLEVELAND CLINIC FOUNDATION (Cleveland, Ohio); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia); Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Margot S. Damaser (Cleveland Heights, Ohio); Swarup Bhunia (Gainesville, Florida); Robert Karam (Gainesville, Florida); Steve Majerus (Akron, Ohio); Dennis Bourbeau (Cleveland, Ohio); Hui Zhu (Pepper Pike, Florida) |
| ABSTRACT | The present disclosure relates generally to using detected bladder events for the diagnosis of urinary incontinence or the treatment of lower urinary tract dysfunction. A system includes a sensing device comprising a pressure sensor to directly detect a pressure within a bladder. The sensing device is adapted to be located within the bladder. The system also includes a signal processing device to: receive a signal indicating the detected pressure within the bladder; detect a bladder event based the detected pressure within the signal; and characterize the bladder event as a bladder contraction event or a non-contraction event. The characterization of the bladder event can be used in the diagnosis of urinary incontinence or the treatment of lower urinary tract dysfunction. |
| FILED | Monday, August 22, 2022 |
| APPL NO | 17/892580 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/03 (20130101) A61B 5/0031 (20130101) A61B 5/076 (20130101) A61B 5/202 (20130101) A61B 5/205 (20130101) Original (OR) Class A61B 5/721 (20130101) A61B 5/726 (20130101) A61B 5/6874 (20130101) A61B 5/7282 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/3606 (20130101) A61N 1/36007 (20130101) A61N 1/36135 (20130101) A61N 1/36167 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230125057 | VAN VOORHIS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington); United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wesley C. VAN VOORHIS (Seattle, Washington); Dustin James MALY (Seattle, Washington); Kayode K. OJO (Seattle, Washington); Gayani PERERA (Seattle, Washington); Stephen R. PLYMATE (Seattle, Washington); Cynthia SPRENGER (Seattle, Washington); Takuma UO (Seattle, Washington); Rama Subba Rao VIDADALA (Seattle, Washington) |
| ABSTRACT | This disclosure relates to compounds, pharmaceutical compositions comprising them, and methods of using the compounds and compositions for treating diseases affected by glycolytic generation of adenosine triphosphate (ATP). More particularly, this disclosure relates to compounds and pharmaceutical compositions thereof, methods of selectively inhibiting glycolysis with these compounds, and methods of treating diseases that benefit from selective glycolysis inhibition, such as cancer. |
| FILED | Thursday, January 07, 2021 |
| APPL NO | 17/758577 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 487/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20230117744 | Baker et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | LOYOLA UNIVERSITY OF CHICAGO (Chicago, Illinois); THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (District Of Columbia, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Susan Baker (Elmhurst, Illinois); Xufang Deng (Lyons, Illinois); Kelly Milton Lager (Colo, Iowa); Kay Faaberg (Ames, Iowa); Alexandra DeVries (Ames, Iowa) |
| ABSTRACT | The present disclosure provides compositions, for example vaccine compositions comprising live, attenuated coronavirus. The disclosure also provides methods of using coronavirus vaccines, including methods of treating and/or preventing coronavirus infections, and provides methods of preparing coronavirus vaccines. |
| FILED | Tuesday, March 23, 2021 |
| APPL NO | 17/914293 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/215 (20130101) Original (OR) Class A61K 2039/5254 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230124398 | AMPATZIDIS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ioannis AMPATZIDIS (Gainesville, Florida); Victor H. MEIRELLES PARTEL (Gainesville, Florida); Lucas FIDELES COSTA (Gainesville, Florida) |
| ABSTRACT | Embodiments of the present disclosure provide methods, apparatus, systems, computing devices, computing entities, and/or the like for detecting objects located in an area of interest. In accordance with one embodiment, a method is provided comprising: receiving, via an interface provided through a general instance on a cloud environment, imaging data comprising raw images collected on the area of interest; upon receiving the images: activating a central processing unit (CPU) focused instance on the cloud environment and processing, via the image, the raw images to generate an image map of the area of interest; and after generating the image map: activating a graphical processing unit (GPU) focused instance on the cloud environment and performing object detection, via the image, on a region within the image map by applying one or more object detection algorithms to the region to identify locations of the objects in the region. |
| FILED | Wednesday, April 21, 2021 |
| APPL NO | 17/907695 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 1/20 (20130101) G06T 7/70 (20170101) G06T 2207/20104 (20130101) Image or Video Recognition or Understanding G06V 10/16 (20220101) G06V 10/25 (20220101) G06V 20/188 (20220101) Original (OR) Class G06V 2201/07 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 20230118232 | BENNINGTON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Spirent Communications PLC (Crawley, United Kingdom) |
| ASSIGNEE(S) | Spirent Communications PLC (Crawley, United Kingdom) |
| INVENTOR(S) | Jeremy Charles BENNINGTON (Greenwood, Indiana); Richard WEST (Paignton, United Kingdom); Paul HANSEN (Cambridge, United Kingdom); Esther ANYAEGBU (Northampton, United Kingdom); Matthew POTTLE (Paignton, United Kingdom) |
| ABSTRACT | Disclosed is determining GNSS satellite position visibility by possessing an orbital segment representing the transit of a satellite in orbit over time, a coarse ray angle interval, a fine ray angle interval, and a digital surface model. Disclosed is propagating coarse ray at coarse ray angle intervals increments in a first pass between an observable point and orbital segment at a respective coarse ray angle to determine whether the coarse ray is obstructed by features of the DSM, and recording a status of the coarse ray based on whether the coarse ray was obstructed. If pairs of successive coarse rays have different status, designating the coarse ray with NLOS visibility, then performing a second pass by propagating, per each designated coarse ray, fine rays at fine ray angle intervals, and saving an indication of time at which LOS visibility to the satellite is obstructed. |
| FILED | Monday, September 19, 2022 |
| APPL NO | 17/948190 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 19/08 (20130101) Original (OR) Class Traffic Control Systems G08G 1/0968 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 67/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230118946 | BENNINGTON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Spirent Communications PLC (Crawley, United Kingdom) |
| ASSIGNEE(S) | Spirent Communications PLC (Crawley, United Kingdom) |
| INVENTOR(S) | Jeremy Charles BENNINGTON (Greenwood, Indiana); Richard WEST (Paignton, United Kingdom); Paul HANSEN (Cambridge, United Kingdom); Esther ANYAEGBU (Northampton, United Kingdom); Matthew POTTLE (Paignton, United Kingdom) |
| ABSTRACT | Disclosed is a method of detecting and rejecting a spoofing or jamming signal source by receiving at a first device a forecast of a visibility for each Global Navigation Satellite System (GNSS) satellite signal source in the forecast at a GNSS receiver coupled to the first device, calculating from at least an elevation and the received visibility of the satellite signal sources in the forecast a predicted Signal to Noise Ratio (SNR), comparing SNR acquired by the GNSS receiver of one or more of the satellite signal sources to the predicted SNR, detecting a spoofing signal source based on acquiring a higher SNR than predicted or a jamming signal source based on acquiring a lower SNR than predicted, and rejecting the spoofing or jamming signal source based on differences between the acquired and predicted SNR. |
| FILED | Monday, September 19, 2022 |
| APPL NO | 17/948176 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 19/08 (20130101) Original (OR) Class Traffic Control Systems G08G 1/0968 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 67/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Central Intelligence Agency (CIA)
| US 20230124917 | Gordon |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Central Intelligence Agency (Washington, District of Columbia) |
| ASSIGNEE(S) | Central Intelligence Agency (Washington, District of Columbia) |
| INVENTOR(S) | Michael P. Gordon (Middletown, Maryland) |
| ABSTRACT | The present subject matter addresses a process and testing procedures for establishing a baseline medical status and tracking changes to an individual's immune system with exposure to impact events over time. In particular, the processes described herein establish a baseline medical status for the individual and, through periodic or otherwise initiated medical sampling, map the changes and development of an individual's immune system using biomarkers for exposures. These biomarkers are cataloged as part of an individual medical profile and can assist in bio-surveillance efforts to identify biomarkers for global under-reported and under-researched pathogens through the study of individuals originating from or visiting highly infectious areas. In particular, the present subject matter relates to a method for the diagnosis of an impact event to physiology as well as a system for implementing such analysis and providing treatment options and alerts. |
| FILED | Friday, October 14, 2022 |
| APPL NO | 17/966181 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/7275 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/80 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Environmental Protection Agency (EPA)
| US 20230122594 | Reiserer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ronald S. Reiserer (Nashville, Tennessee); David K. Schaffer (Nashville, Tennessee); Philip C. Samson (Nashville, Tennessee); Dmitry A. Markov (Nashville, Tennessee); Michael Geuy (Nashville, Tennessee); Lisa J. McCawley (Nashville, Tennessee); John P. Wikswo (Brentwood, Tennessee) |
| ABSTRACT | Microfluidic systems, pumps, valves and applications of the same are provided. The microfluidic system may be a pump or a valve having a fluidic chip and an actuator controlling the opening and closing of the fluidic channel in the fluidic chip. The actuator may be disposed to tilt from the fluidic chip, forming a tilted-rotor peristaltic pump. Alternatively, the actuator may be a rolling ball actuator, and different fluidic chips may be used in different applications. For example, the fluidic chip may be a spiral pump chip having spiral channels, a rotary peristaltic pump chip having multiple output channels, or a multi-port valve chip having one port interconnected with multiple different ports. An analytical valve chip may switchably interconnect bioreactor and rinse/calibration input channels to sensor and waste output channels. The actuator of a random-access valve can move from one valve position to another without opening or closing intermediate ones. |
| FILED | Tuesday, December 20, 2022 |
| APPL NO | 18/084634 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502738 (20130101) Original (OR) Class B01L 2300/123 (20130101) B01L 2300/0627 (20130101) B01L 2400/0644 (20130101) Positive-displacement Machines for Liquids; Pumps F04B 43/1261 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Non-Profit Organization (NPO)
| US 20230121081 | Parikh |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Houston System (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pranav J. Parikh (Richmond, Texas) |
| ABSTRACT | A hand function testing device includes a base having a number of rigid wires protruding from a surface thereof, each rigid wire having a stationary bead affixed at a predetermined position along the rigid wire, a moving bead movably mounted on the rigid wire and movable along a working region of the rigid wire defined between a base-end of the rigid wire and the stationary bead, the moving bead being mounted on the rigid wire via reception of the rigid wire through a lumen in the moving bead, and at least one force sensing element for measuring a force input to the moving bead. A method of testing hand function includes using the hand function testing device to measure a force input to a moving bead as the moving bead is moved within a working region on the rigid wire. |
| FILED | Monday, October 10, 2022 |
| APPL NO | 17/962597 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/1121 (20130101) A61B 5/1125 (20130101) Original (OR) Class A61B 2562/0252 (20130101) Toys, e.g Tops, Dolls, Hoops or Building Blocks A63H 33/00 (20130101) Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Office of the Director of National Intelligence (ODNI)
| US 20230122594 | Reiserer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ronald S. Reiserer (Nashville, Tennessee); David K. Schaffer (Nashville, Tennessee); Philip C. Samson (Nashville, Tennessee); Dmitry A. Markov (Nashville, Tennessee); Michael Geuy (Nashville, Tennessee); Lisa J. McCawley (Nashville, Tennessee); John P. Wikswo (Brentwood, Tennessee) |
| ABSTRACT | Microfluidic systems, pumps, valves and applications of the same are provided. The microfluidic system may be a pump or a valve having a fluidic chip and an actuator controlling the opening and closing of the fluidic channel in the fluidic chip. The actuator may be disposed to tilt from the fluidic chip, forming a tilted-rotor peristaltic pump. Alternatively, the actuator may be a rolling ball actuator, and different fluidic chips may be used in different applications. For example, the fluidic chip may be a spiral pump chip having spiral channels, a rotary peristaltic pump chip having multiple output channels, or a multi-port valve chip having one port interconnected with multiple different ports. An analytical valve chip may switchably interconnect bioreactor and rinse/calibration input channels to sensor and waste output channels. The actuator of a random-access valve can move from one valve position to another without opening or closing intermediate ones. |
| FILED | Tuesday, December 20, 2022 |
| APPL NO | 18/084634 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502738 (20130101) Original (OR) Class B01L 2300/123 (20130101) B01L 2300/0627 (20130101) B01L 2400/0644 (20130101) Positive-displacement Machines for Liquids; Pumps F04B 43/1261 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20230120878 | Zhou et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Little Rock, Arkansas) |
| ASSIGNEE(S) | BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Little Rock, Arkansas) |
| INVENTOR(S) | Wenchao Zhou (Fayetteville, Arkansas); Marques Lucas (Fayetteville, Arkansas); Zachary Hyden (Fayetteville, Arkansas); Pablo Guerra (Fayetteville, Arkansas) |
| ABSTRACT | The present invention provides a swarm manufacturing platform, based on a swarm 3D printing and assembly (SPA) platform as a model for future smart factories, consisting of thousands of IoT-based mobile robots performing different manufacturing operations with different end effectors (e.g., material deposition, energy deposition, pick and place, removal of materials, screw driving, etc.) and real-time monitoring. The swarm manufacturing platform transforms a 1-D factory into a 2-D factory with manufacturing robots that can move across the 2-D factory floor, work cooperatively with each other on the same production jobs, and re-configure in real-time (i.e., the manufacturing robots can be digitally controlled to move, re-group, calibrate, and work on a new job in real-time). |
| FILED | Thursday, February 11, 2021 |
| APPL NO | 17/798877 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/0009 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/171 (20170801) B29C 64/227 (20170801) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 30/00 (20141201) Systems for Controlling or Regulating Non-electric Variables G05D 1/0261 (20130101) G05D 1/0297 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
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How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, April 20, 2023.
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APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
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- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
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