FedInvent™ Patent Applications
Application Details for Thursday, April 27, 2023
This page was updated on Thursday, April 27, 2023 at 11:00 AM GMT
Department of Health and Human Services (HHS)
| US 20230125131 | Gao et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Liang Gao (Santa Clara, California); Xiaohua Feng (Los Angeles, California) |
| ABSTRACT | Systems and methods are provided for ultrafast light field tomography (LIFT), a transient imaging strategy that offers a temporal sequence of over 1000 and enables highly efficient light field acquisition, allowing snapshot acquisition of the complete two, three or four-dimensional space and time. The apparatus transforms targets in object space into parallel lines in the image plane with a cylindrical lens. Beam projections are optionally directed through a Dove prism and an array of cylindrical lenslets to an imaging device such as a SPAD camera, streak camera and CCD camera. By using an array of cylindrical lenslets oriented at distinct angles, enough projections are obtained simultaneously to recover the image with a single snapshot. The time-resolved system and methods were adapted to LIDAR, hyperspectral, non-line-of-sight, and three-dimensional transient imaging. |
| FILED | Wednesday, October 12, 2022 |
| APPL NO | 18/046016 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 30/27 (20200101) Original (OR) Class Pictorial Communication, e.g Television H04N 13/232 (20180501) H04N 23/957 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230125415 | Bao et al. |
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| FUNDED BY |
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| APPLICANT(S) | Genentech, Inc. (South San Francisco, California) |
| ASSIGNEE(S) | Genentech, Inc. (South San Francisco, California) |
| INVENTOR(S) | Min Bao (Cupertino, California); Fang Cai (South San Francisco, California); Jennifer Tom (Hillsborough, California); Larry Wilse Tsai (Hillsborough, California) |
| ABSTRACT | A method of treating pneumonia in a patient is disclosed comprising administering an effective amount of an IL-6 antagonist to a patient identified as having elevated ferritin level. Also disclosed is a method of achieving an improved clinical response in a patient with pneumonia comprising: a. measuring ferritin level in the patient, and b. administering an effective amount of an IL-6 antagonist to the patient identified as having an elevated ferritin level. The improved clinical response achieved includes: no death by Day 28, not mechanically ventilated by Day 28 (wherein the patient was not mechanically ventilated at baseline), better ordinal score at Day 28, and/or reduced time to hospital discharge within 28 days, compared to the clinical response in a patient with pneumonia and ferritin level that is not elevated. Moreover, a method of reducing time to hospital discharge in a patient with pneumonia comprising administering an effective amount of the IL-6 antagonist to the patient is disclosed, wherein the patient prior to treatment: a. is receiving non-invasive ventilation or high flow oxygen, or is intubated and being mechanically ventilated, and b. has been identified as having elevated IL-6 level. |
| FILED | Friday, March 19, 2021 |
| APPL NO | 17/906908 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/675 (20130101) A61K 38/1793 (20130101) A61K 39/3955 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/2866 (20130101) Original (OR) Class C07K 2317/24 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6869 (20130101) G01N 2333/79 (20130101) G01N 2333/5412 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230125467 | Chen et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhongping Chen (Irvine, California); Yusi Miao (Irvine, California); Yan Li (Irvine, California); Bruce J. Tromberg (Irvine, California); Yona Tadir (Irvine, California) |
| ABSTRACT | The present invention features a method for automated image-based prediction of physiologic and pathologic conditions of a vaginal wall of a patient using optical coherence tomography. In some embodiments, the method may comprise capturing, by a functional optical coherence tomography imaging probe, one or more images of the vaginal wall. The method may further comprise constructing a computing device a visualization of the vaginal wall, discretizing the visualization of the vaginal wall in to a discrete model, measuring a plurality of objective attributes from the discrete model, generating, based on the plurality of objective attributes, a Vaginal Health Index (VHI), generating an associated risk value based on the VHI and a plurality of patient attributes, reconstructing the visualization of the vaginal wall based on the associated risk value, and mapping the associated risk value to the visualization of the vaginal wall such that one or more at-risk areas are highlighted. |
| FILED | Friday, November 18, 2022 |
| APPL NO | 18/056966 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/303 (20130101) A61B 5/0066 (20130101) A61B 5/4337 (20130101) A61B 5/7275 (20130101) Original (OR) Class A61B 5/14539 (20130101) A61B 8/485 (20130101) A61B 8/4416 (20130101) Image Data Processing or Generation, in General G06T 7/136 (20170101) G06T 7/149 (20170101) G06T 7/162 (20170101) G06T 2207/10101 (20130101) G06T 2207/10132 (20130101) G06T 2207/20081 (20130101) G06T 2207/30004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230125614 | TAVAZOIE et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Saeed TAVAZOIE (New York, New York); Panagiotis OIKONOMOU (New York, New York) |
| ABSTRACT | Described herein is a method for producing in vivo mRNA displayed proteins by linking of in vivo expressed proteins to in vivo expressed RNA sequences that enable specific downstream identification of the individual proteins through nucleic acid-based sequencing. RNA-protein linkage is enabled by fusing an RNA-binding domain (e.g., MS2 coat protein) to a protein of interest that is expressed in a cell or compartment in which is also expressed the RNA sequence harboring both the recognition element for the RNA-binding domain (e.g., MS2 stem-loop) and an identifying sequence that uniquely maps to the protein of interest. The identifying sequence can be the coding sequence corresponding to the protein of interest or any RNA barcode that by design uniquely corresponds to the protein of interest. As such, libraries of such in vivo mRNA displayed proteins can be assayed in parallel for a variety of protein behaviors and functions. |
| FILED | Friday, March 05, 2021 |
| APPL NO | 17/905583 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1062 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230125881 | GRINSTAFF et al. |
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| FUNDED BY |
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| APPLICANT(S) | TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts) |
| ASSIGNEE(S) | TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts) |
| INVENTOR(S) | Mark GRINSTAFF (Brookline, Massachusetts); Aladin HAMOUD (Brookline, Massachusetts); Samantha BERRY (Brighton, Massachusetts); Christopher GROMISCH (Hamden, Connecticut) |
| ABSTRACT | Provided herein are novel polypeptides, methods for their production and uses thereof. |
| FILED | Tuesday, July 26, 2022 |
| APPL NO | 17/873864 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/65 (20170801) A61K 47/6803 (20170801) A61K 47/6849 (20170801) Peptides C07K 16/28 (20130101) Original (OR) Class C07K 16/2863 (20130101) C07K 2317/24 (20130101) C07K 2319/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230125917 | Gallo et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
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| INVENTOR(S) | Richard L. Gallo (San Diego, California); Teruaki Nakatsuji (San Diego, California) |
| ABSTRACT | The disclosure provides for novel antimicrobial agents, methods of making, and methods of use thereof. |
| FILED | Wednesday, June 08, 2022 |
| APPL NO | 17/835307 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) A61K 31/52 (20130101) A61K 31/53 (20130101) A61K 31/506 (20130101) A61K 31/519 (20130101) A61K 31/4188 (20130101) A61K 31/5025 (20130101) A61K 31/5365 (20130101) A61K 31/5395 (20130101) Original (OR) Class A61K 35/74 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Heterocyclic Compounds C07D 413/04 (20130101) C07D 473/18 (20130101) C07D 473/34 (20130101) C07D 487/04 (20130101) C07D 498/04 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230125935 | Chang et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Howard Y. Chang (Stanford, California); Chun-Kan Chen (Stanford, California) |
| ABSTRACT | Provided herein are recombinant circular RNA (circRNA) molecules comprising an internal ribosome entry site (IRES) operably linked to a protein-coding nucleic acid sequence. The IRES includes at least one RNA secondary structure element; and a sequence region that is complementary to an 18S ribosomal RNA (rRNA). Methods of producing a protein in a cell using the recombinant circRNA molecules are also provided. |
| FILED | Monday, October 03, 2022 |
| APPL NO | 17/937617 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/67 (20130101) Original (OR) Class C12N 15/85 (20130101) C12N 15/113 (20130101) C12N 2840/203 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230126276 | Pravetoni et al. |
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| FUNDED BY |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota); ALLEGHENY-SINGER RESEARCH INSTITUTE (Pittsburgh, Pennsylvania); RTI INTERNATIONAL (Research Park, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marco Pravetoni (Minneapolis, Minnesota); Saadyah Averick (Pittsburgh, Pennsylvania); Scott Runyon (Research Park, North Carolina) |
| ABSTRACT | This disclosure describes fentanyl haptens, a fentanyl hapten-carrier conjugate, methods of making the fentanyl hapten-carrier conjugate, and methods of using the fentanyl hapten-carrier conjugate including, for example, as a prophylactic vaccine to counteract toxicity from exposure to fentanyl, fentanyl derivatives, and fentanyl analogs. In some embodiments, the fentanyl hapten-carrier conjugate or a composition including the fentanyl hapten-carrier conjugate may be used in an anti-opioid vaccine. |
| FILED | Friday, March 12, 2021 |
| APPL NO | 17/909874 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4468 (20130101) A61K 39/0013 (20130101) A61K 39/385 (20130101) Original (OR) Class A61K 47/643 (20170801) A61K 47/646 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230126396 | Schnell et al. |
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| FUNDED BY |
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| APPLICANT(S) | Thomas Jefferson University (Philadelphia, Pennsylvania); ICAHN School of Medicine at Mount Sinai (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthias Schnell (Harleysville, Pennsylvania); Christine Rettew Fisher (Philadelphia, Pennsylvania); Christoph Wirblich (Philadelphia, Pennsylvania); Gene Tan (La Jolla, California) |
| ABSTRACT | The present disclosure is directed towards chimeric glycoproteins wherein the clip region, a core region, a flap region, and a transmembrane and cytoplasmic domain are defined by starting from the amino terminus of the protein, these domains are comprised of the following amino acid residue ranges: clip, 1 through 40 to 60; core, 40 to 60 through 249 to 281; flap, 249 to 281 through 419 to 459; the transmembrane domain is comprised of amino acids 460 through 480, and the remaining amino acids 481 through 525 comprise the cytoplasmic domain; and wherein the clip, core, flap, transmembrane, and cytoplasmic domain comprise a chimeric combination of at least two lyssavirus, wherein the chimeric glycoprotein is advantageously inserted into a rabies-based vaccine vector. |
| FILED | Thursday, October 13, 2022 |
| APPL NO | 18/046243 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class A61K 2039/5252 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230126413 | XU et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland); Kennedy Krieger Institute, Inc. (Baltimore, Maryland); City University of Hong Kong (Kowloon Tong, China Hong Kong) |
| INVENTOR(S) | Jiadi XU (Timonium, Maryland); Peter VAN ZIJL (Hanover, Maryland); Lin CHEN (Baltimore, Maryland); Kannie Wai Yan CHAN (Hong Kong, China PRC); Jianpan HUANG (Hong Kong, China PRC) |
| ABSTRACT | A method of assessing the brain lymphatic or glymphatic system and the glucose transporter function on blood-cerebrospinal fluid barrier (BCSFB) of a subject using D-glucose or a D-glucose analog. A spatial map is generated of water MR signals that are sensitized to changes in D-glucose or a D-glucose analog in cerebrospinal fluid (CSF) of the subject. The spatial map is observed at one or more time points before, one or more time points during, and one or more time points after, raising the blood level of the D-glucose or a D-glucose analog in the subject CSF. A difference is detected between the MR signals of the spatial map before, during, and after raising the blood level of D-glucose or a D-glucose analog. A physiological parameter associated with the brain lymphatic or glymphatic system and the glucose transporter function on BCSFB of the subject is ascertained based on the detected difference. |
| FILED | Wednesday, April 07, 2021 |
| APPL NO | 17/918031 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) Original (OR) Class Measuring Electric Variables; Measuring Magnetic Variables G01R 33/565 (20130101) G01R 33/4833 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230126784 | GOLDSTEIN et al. |
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| FUNDED BY |
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| APPLICANT(S) | ALBERT EINSTEIN COLLEGE OF MEDICINE (Bronx, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Harris GOLDSTEIN (Bronx, New York); Steven C ALMO (Bronx, New York); Scott GARFORTH (Bronx, New York); Mengyan LI (Bronx, New York) |
| ABSTRACT | The present disclosure relates to a method of modulating one or more genetically modified cells, e.g., chimeric antigen receptor (CAR)-expressing cells, ex vivo and/or in vivo. |
| FILED | Monday, March 08, 2021 |
| APPL NO | 17/905325 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 35/02 (20180101) Peptides C07K 14/005 (20130101) C07K 14/7051 (20130101) C07K 14/70539 (20130101) C07K 16/2818 (20130101) C07K 16/2878 (20130101) C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 15/86 (20130101) C12N 2710/16122 (20130101) C12N 2710/16134 (20130101) C12N 2740/15043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230126796 | Bray et al. |
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| APPLICANT(S) | UNIVERSITY OF UTAH RESEARCH FOUNDATION (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul F. Bray (Salt Lake City, Utah); Robert A. Campbell (Salt Lake City, Utah); Michelle Stoller (Salt Lake City, Utah) |
| ABSTRACT | Disclosed herein are a synthetic peptide mimetic and compositions comprising the synthetic peptide mimetic that induce activation of and signaling through PAR4. Also disclosed herein are methods of treating a bleeding disorder comprising administering the synthetic peptide. |
| FILED | Friday, September 23, 2022 |
| APPL NO | 17/934816 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/04 (20180101) Peptides C07K 7/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230126916 | Lupton et al. |
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| FUNDED BY |
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| APPLICANT(S) | Myolex Inc (Brookline, Massachusetts) |
| ASSIGNEE(S) | Myolex Inc. (Brookline, Massachusetts) |
| INVENTOR(S) | Elmer C Lupton (Charlestown, Massachusetts); Haydn Taylor (Windham, New Hampshire); Ken Li (Wellesley, Massachusetts); Michael Rinehart (San Jose, California); Jose Bohorquez (Brookline, Massachusetts) |
| ABSTRACT | Embodiments of devices and methods for evaluating tissue are disclosed. In one embodiment, a method for measuring a characteristic of a tissue may include passing a current through the tissue, measuring a signal corresponding to the voltage resulting from passing the current through the tissue, analyzing current passed through the tissue and resulting voltage to determine the electrical characteristics of the tissue; and analyzing the electrical characteristics of the tissue to determine a status of the tissue. Methods for achieving relatively constant sensor application pressure are disclosed. |
| FILED | Sunday, February 13, 2022 |
| APPL NO | 17/670479 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/053 (20130101) Original (OR) Class A61B 5/486 (20130101) A61B 5/0537 (20130101) A61B 5/684 (20130101) A61B 5/742 (20130101) A61B 5/4519 (20130101) A61B 5/6843 (20130101) A61B 5/7221 (20130101) A61B 5/7225 (20130101) A61B 5/7278 (20130101) A61B 5/7405 (20130101) A61B 5/7475 (20130101) A61B 2017/0023 (20130101) A61B 2560/0443 (20130101) A61B 2560/0468 (20130101) A61B 2562/04 (20130101) A61B 2562/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230126966 | Hasty et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeff Hasty (Encinitas, California); Lev Tsimring (San Diego, California); Spencer R. Scott (Rancho Santa Fe, California); Muhammad Omar Din (San Diego, California) |
| ABSTRACT | Provided are bacterial strains, methods of culturing bacterial cells using synthetic quorum-regulated lysis, and uses thereof. |
| FILED | Wednesday, November 30, 2022 |
| APPL NO | 18/072256 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/16 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) Original (OR) Class Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/19 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230127123 | Marasco et al. |
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| FUNDED BY |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wayne A. Marasco (Wellesley, Massachusetts); Matthew Chang (Brookline, Massachusetts) |
| ABSTRACT | The present invention is directed to human monoclonal antibodies that bind to the cell-surface receptor, PDL-1 (programmed death ligand 1). The antibodies can be used to treat cancer and chronic viral infections. |
| FILED | Wednesday, December 02, 2020 |
| APPL NO | 17/780389 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/3955 (20130101) A61K 45/06 (20130101) Peptides C07K 14/7051 (20130101) C07K 14/70521 (20130101) C07K 14/70578 (20130101) C07K 16/2827 (20130101) Original (OR) Class C07K 2317/31 (20130101) C07K 2317/55 (20130101) C07K 2317/92 (20130101) C07K 2317/565 (20130101) C07K 2317/622 (20130101) C07K 2319/02 (20130101) C07K 2319/03 (20130101) C07K 2319/33 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230127263 | Dotti et al. |
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| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gianpietro Dotti (Chapel Hill, North Carolina); Yang Xu (Shenzhen, China PRC); Xingcong Ma (Xi'an, China PRC) |
| ABSTRACT | Disclosed herein are modified T cells comprising an IL12β p40 subunit. Also disclosed herein are methods of increasing T cell proliferation and/or methods of treating cancer by administering the modified T cells comprising an IL12β p40 subunit. |
| FILED | Sunday, September 20, 2020 |
| APPL NO | 17/762360 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/5434 (20130101) C07K 14/7155 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230127277 | ILIEV et al. |
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| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Iliyan ILIEV (New York, New York); Irina LEONARDI (Long Island City, New York) |
| ABSTRACT | Provided herein is a method of treating an individual afflicted with an inflammatory bowel disease utilizing Candida abundance as a biomarker of responsiveness. The method comprises determining levels of Candida in a sample from the gastrointestinal tract of an individual, and if the level of Candida is higher than a reference level, identifying the individual as suitable for microbiota transplantation therapy (MTT), and optionally, administering to such an individual the MTT, and in individuals having gastrointestinal tract Candida levels lower than a reference level, increasing the Candida levels prior to prior to administration of MTT. |
| FILED | Monday, March 29, 2021 |
| APPL NO | 17/907449 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/741 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/00 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230127304 | WAGNER et al. |
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| FUNDED BY |
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| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts); DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts); DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| INVENTOR(S) | Gerhard WAGNER (Cambridge, Massachusetts); Christoph GORGULLA (Cambridge, Massachusetts); Zi-Fu WANG (Cambridge, Massachusetts); Haribabu ARTHANARI (Cambridge, Massachusetts); Andras Pal BOESZOERMENYI (Boston, Massachusetts) |
| ABSTRACT | Described herein are compounds, compositions and methods useful for inhibiting Kelch-like ECH-associated protein 1 (KEAP1). The compounds, compositions and methods described herein are useful for treating diseases, disorders or conditions associated with KEAP1. |
| FILED | Tuesday, March 02, 2021 |
| APPL NO | 17/908422 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/18 (20130101) A61K 31/41 (20130101) A61K 31/44 (20130101) A61K 31/47 (20130101) A61K 31/50 (20130101) A61K 31/53 (20130101) A61K 31/55 (20130101) A61K 31/196 (20130101) A61K 31/341 (20130101) A61K 31/351 (20130101) A61K 31/366 (20130101) A61K 31/403 (20130101) A61K 31/421 (20130101) A61K 31/422 (20130101) A61K 31/433 (20130101) A61K 31/437 (20130101) A61K 31/454 (20130101) A61K 31/473 (20130101) A61K 31/498 (20130101) A61K 31/502 (20130101) A61K 31/506 (20130101) A61K 31/538 (20130101) A61K 31/635 (20130101) A61K 31/655 (20130101) Original (OR) Class A61K 31/4155 (20130101) A61K 31/4184 (20130101) A61K 31/4192 (20130101) A61K 31/4245 (20130101) A61K 31/4375 (20130101) A61K 31/4439 (20130101) A61K 31/4709 (20130101) A61K 31/4725 (20130101) A61K 31/4985 (20130101) A61K 31/5025 (20130101) A61K 31/5377 (20130101) A61K 31/5513 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230127401 | Bekelman et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Justin Eli Bekelman (Philadelphia, Pennsylvania); Ravi Bharat Parikh (Philadelphia, Pennsylvania); Jinbo Chen (Newtown, Pennsylvania); Jill Schnall Hasler (Conshohocken, Pennsylvania) |
| ABSTRACT | Methods, systems, and computer readable media for predicting patient outcomes. In some examples, a method includes training, using at least one processor, a predictive model by fitting a first model using patient outcome data for a number of individuals and electronic health record data for individuals. Training the predictive model includes fitting a second model using patient reported outcome data for a subset of the plurality of individuals. The method includes supplying patient data for a patient to the predictive model and using the predictive model to predict at least one patient outcome for the patient. |
| FILED | Monday, October 24, 2022 |
| APPL NO | 17/972105 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 5/022 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) G16H 50/30 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230127462 | Bergeson et al. |
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| FUNDED BY |
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| APPLICANT(S) | Texas Tech University System (Lubbock, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Susan E. Bergeson (Lubbock, Texas); Peter Syapin (Camarillo, California); Ted W. Reid (Wolfforth, Texas); Mayank Shastri (Lubbock, Texas); Phat Tran (Lubbock, Texas) |
| ABSTRACT | A method of treating Alcohol Use Disorder (AUD), Substance Use Disorder (SUD), tobacco use, pain, or proinflammatory disorders comprising: providing a subject with an effective amount of a modified tetracycline or derivative thereof to ameliorate or eliminate the AUD, SUD, tobacco use, pain, or proinflammatory disorder, and wherein the modified tetracycline or derivative thereof has reduced binding to a microbial ribosome and has the formula: wherein R1 is acetyl, R2 is OH or acetyl, R3 is acetyl, R4 is H or acetyl, and R5 is acetyl. |
| FILED | Tuesday, November 29, 2022 |
| APPL NO | 18/059533 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4848 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/65 (20130101) Acyclic or Carbocyclic Compounds C07C 237/26 (20130101) Original (OR) Class C07C 2603/46 (20170501) Heterocyclic Compounds C07D 317/72 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230127487 | Sangaralingham et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sasantha J. Sangaralingham (Rochester, Minnesota); Xiao Ma (Rochester, Minnesota); John C. Burnett, Jr. (Rochester, Minnesota) |
| ABSTRACT | This document provides methods and materials involved in assessing mammals with acute decompensated heart failure (ADHF), as well as methods and materials involved in assessing outcomes. For example, methods and materials for using the level of plasma CNP and the level of urinary CNP to determine whether or not a mammal is developing or likely to develop more severe ADHF, as well as methods and materials for using the level of plasma CNP and the level of urinary CNP to identify patients having an increased likelihood of experiencing a poor outcome are provided. |
| FILED | Friday, March 12, 2021 |
| APPL NO | 17/911285 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/2242 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 43/00 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) G01N 2333/58 (20130101) G01N 2800/325 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230127548 | Yeo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eugene Yeo (La Jolla, California); Eric Van Nostrand (La Jolla, California); Nathan Gianneschi (La Jolla, California); David A. Nelles (La Jolla, California); Sarah Barnhill (La Jolla, California); Anthony Rush (La Jolla, California) |
| ABSTRACT | Provided herein are methods of identifying a cell uptake modulator of a molecule that include (a) contacting a plurality of cells of a cell-containing biological sample with a plurality of gene-editing agents, wherein a gene-editing agent from the plurality of gene-editing agents recognizes and alters a target gene of at least one cell of the plurality of cells; (b) contacting the plurality of cells with a plurality of molecules, wherein at least one molecule of the plurality of molecules is transported into at least one cell of the plurality of cells; and (c) detecting a presence of the at least one molecule in the plurality of cells, thereby identifying the cell uptake modulator of the molecule. |
| FILED | Wednesday, September 28, 2022 |
| APPL NO | 17/936216 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1079 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230127630 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CITY OF HOPE (Duarte, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jianjun Chen (Temple City, California); Hengyou Weng (Duarte, California); Huilin Huang (Duarte, California); David Horne (Altadena, California); Yuelong Ma (Glendora, California); Hongzhi Li (Diamond Bar, California); Xiaolan Deng (Temple City, California) |
| ABSTRACT | Described herein, inter alia, are IGF2BP2 inhibitor compounds and methods of using the same. |
| FILED | Wednesday, January 27, 2021 |
| APPL NO | 17/794922 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 243/38 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230127636 | Qin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Cleveland Clinic Foundation (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jun Qin (Solon, Ohio); Koichi Fukuda (Cleveland Heights, Ohio); Julia Vaynberg (Rocky River, Ohio); Suguna Rachakonda (Copley, Ohio) |
| ABSTRACT | The present invention relates to compounds that are modulators of Integrin Linked Kinase (ILK), and methods of treating diseases with such compounds. In certain embodiments, the compounds are within Formulas I-VII (e.g., Csbl-1). In some embodiments, the compounds are used to treat an ILK-mediated disease, such as cancer (e.g., triple negative breast cancer) or an inflammatory disease. |
| FILED | Tuesday, November 01, 2022 |
| APPL NO | 18/051762 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 239/94 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230127823 | Wei et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fang Wei (North Hills, California); David T.W. Wong (Beverly Hills, California); Wu-Chou Su (Tainan, Taiwan) |
| ABSTRACT | A system and method for the detection of saliva biomarkers in bodily fluids is described. In particular, the system is suitable for detecting biomarkers of lung cancer in a subject. The system includes an electrochemical sensor chip having at least one well, wherein the at least one well contains a working electrode coated with a conducting polymer functionalized with at least one capture probe, and at least one labeled detector probe. When the at least one labeled detector probe is mixed with a sample of the subject containing a biomarker of lung cancer and added to the at least one well, an electric current is applied to the sample, such that when at least some of the biomarker binds to the capture probe, a measurable change in electric current in the sample is created that is indicative of lung cancer. |
| FILED | Monday, September 12, 2022 |
| APPL NO | 17/931205 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6825 (20130101) Original (OR) Class C12Q 1/6886 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/3276 (20130101) G01N 33/5438 (20130101) G01N 33/57423 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230127861 | Madala |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Children's Hospital Medical Center (Cincinnati, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Satish Kumar Madala (Cincinnati, Ohio) |
| ABSTRACT | Disclosed herein are methods for treating an individual having, or at risk of having, pulmonary fibrosis, wherein volasertib, a salt thereof, or hydrate thereof, is administered to the individual in need thereof. In one aspect, the pulmonary fibrosis may be idiopathic pulmonary fibrosis. The volasertib may be administered in an amount and for a duration of time effective to achieve one or more outcomes selected from decreased invasiveness of pulmonary fibroblasts, increased clearance of myofibroblasts, decreased migration of pulmonary fibroblasts, decreased pulmonary fibroblast proliferation, decreased cell adhesion of pulmonary fibroblasts, decreased myofibroblast activation, decreased extracellular matrix (ECM) accumulation or production, and improved lung function. |
| FILED | Tuesday, October 25, 2022 |
| APPL NO | 17/972963 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/496 (20130101) A61K 31/519 (20130101) Original (OR) Class A61K 31/4418 (20130101) A61K 39/3955 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230127944 | BURNS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Venatorx Pharmaceuticals, Inc. (Malvern, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher J. BURNS (Malvern, Pennsylvania); Guo-Hua CHU (Exton, Pennsylvania); Jodie HAMRICK (New Holland, Pennsylvania); Steven A. BOYD (Chester Springs, Pennsylvania); Stephen M. CONDON (Glenmoore, Pennsylvania) |
| ABSTRACT | The present disclosure provides broad-spectrum carbapenem derivatives and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such derivatives and/or compositions. |
| FILED | Thursday, September 17, 2020 |
| APPL NO | 17/778199 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/2013 (20130101) A61K 9/2018 (20130101) A61K 9/2054 (20130101) A61K 9/2059 (20130101) A61K 9/4825 (20130101) A61K 9/4858 (20130101) A61K 31/69 (20130101) A61K 31/407 (20130101) Original (OR) Class A61K 31/454 (20130101) A61K 31/506 (20130101) A61K 31/4439 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Heterocyclic Compounds C07D 477/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230127948 | Gootenberg et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan Gootenberg (Cambridge, Massachusetts); Omar Abudayyeh (Cambridge, Massachusetts); Julia Joung (Cambridge, Massachusetts); Alim Ladha (Cambridge, Massachusetts); Han Altae-Tran (Cambridge, Massachusetts); Guilhem Faure (Cambridge, Massachusetts); Feng Zhang (Cambridge, Massachusetts) |
| ABSTRACT | Systems and methods for rapid diagnostics related to the use of CRISPR effector systems and optimized guide sequences for detection of coronavirus, including multiplex lateral flow diagnostic devices and methods of use, are provided. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/798248 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/701 (20130101) C12Q 1/6844 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230128029 | Anderson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David J. Anderson (Altadena, California); Moriel Zelikowsky (Pasadena, California); Andrea Choe (Los Angeles, California) |
| ABSTRACT | In some embodiments, methods of inhibiting, ameliorating, reducing the severity of, treating, reducing the likelihood of, or preventing social isolation stress or symptoms thereof in a subject in need thereof are described. In some embodiments, methods of determining a risk of social isolation stress in a subject are described. |
| FILED | Friday, September 30, 2022 |
| APPL NO | 17/937067 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4545 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 43/00 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/68 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230128072 | Sykora |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Amelia Technologies (Washington D.C., District of Columbia) |
| ASSIGNEE(S) | Amelia Technologies (Washington D.C., District of Columbia) |
| INVENTOR(S) | Peter Sykora (Baltimore, Maryland) |
| ABSTRACT | Composition, systems, and methods for the induction of biological endpoints in a cheap contained system. In many embodiments, variation on well numbers on plates and ranging ultraviolet wavelengths produces different and controlled outcomes of the biological endpoint induction. Endpoint induction of this type allows for chemical induction, wherein the system can be turned on and off in short time periods. |
| FILED | Saturday, September 24, 2022 |
| APPL NO | 17/935093 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/06 (20130101) Original (OR) Class Non-electric Light Sources Using Luminescence; Light Sources Using Electrochemiluminescence; Light Sources Using Charges of Combustible Material; Light Sources Using Semiconductor Devices as Light-generating Elements; Light Sources Not Otherwise Provided for F21K 9/64 (20160801) Indexing Scheme Associated With Subclasses F21K, F21L, F21S and F21V, Relating to the Form or the Kind of the Light Sources or of the Colour of the Light Emitted F21Y 2115/10 (20160801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230128120 | Cui et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington); Albert Einstein College of Medicine (Bronx, New York) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington); Albert Einstein College of Medicine (Bronx, New York) |
| INVENTOR(S) | Julia Yue Cui (Seattle, Washington); Sridhar Mani (Bronx, New York); Moumita Dutta (Seattle, Washington) |
| ABSTRACT | Methods for activating pregnane X receptor (PXR) using co-muricholic acid thereby treating metabolic syndrome, obesity, inflammatory bowel disease, Crohn’s disease, and liver disease, and also thereby increasing CYP3A4 gene and/or protein expression. Also provided are related methods for activating PXR using β-muricholic acid and a bacterium capable of converting β-muricholic acid to co-muricholic acid. |
| FILED | Friday, October 21, 2022 |
| APPL NO | 18/048719 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 31/575 (20130101) Original (OR) Class A61K 35/74 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 33/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230128322 | Low et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Philip Stewart Low (West Lafayette, Indiana); Francesco Michelangelo Turrini (Sassari, Italy); Kristina Rose Kesely (Lafayette, Indiana); Antonella Pantaleo (Sassari, Italy) |
| ABSTRACT | The disclosure relates to methods, compositions, and kits for treatment of parasite-mediated disease. In one embodiment, the disclosure relates to compounds, compositions, methods and kits for the treatment of malaria. In still another embodiment, the disclosure relates to a method for treating malaria comprising the use of a Syk kinase inhibitor. |
| FILED | Wednesday, September 21, 2022 |
| APPL NO | 17/934107 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/05 (20130101) A61K 31/49 (20130101) A61K 31/52 (20130101) A61K 31/366 (20130101) A61K 31/404 (20130101) A61K 31/505 (20130101) A61K 31/506 (20130101) A61K 31/519 (20130101) Original (OR) Class A61K 31/675 (20130101) A61K 31/4706 (20130101) A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230128340 | Weissman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Irving L. Weissman (Stanford, California); Agnieszka Czechowicz (Menlo Park, California); Deepta Bhattacharya (San Francisco, California); Daniel Kraft (Portola Valley, California) |
| ABSTRACT | The present invention provides a clinically applicable method of stem cell transplantation that facilitates engraftment and reconstitutes immunocompetence of the recipient without requiring radiotherapy or chemotherapy, and without development of GVHD or graft rejection. Aspects of the present invention are based on the discovery that the depletion of the endogenous stem cell niche facilitates efficient engraftment of stem cells into that niche. In particular, the present invention combines the use of selective ablation of endogenous stem cells, in combination with the administration to the recipient of exogenous stem cells, resulting in efficient, long-term engraftment and tolerance. |
| FILED | Thursday, December 22, 2022 |
| APPL NO | 18/087618 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) A61K 39/3955 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/32 (20130101) C07K 16/2803 (20130101) C07K 16/2812 (20130101) C07K 16/2815 (20130101) C07K 16/2866 (20130101) C07K 16/2896 (20130101) Original (OR) Class C07K 2317/73 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230128344 | ZHANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | University of Southern California (Los Angeles, California) |
| INVENTOR(S) | Yong ZHANG (Los Angeles, California); Zhefu DAI (Los Angeles, California); Xiao-Nan ZHANG (Los Angeles, California) |
| ABSTRACT | Antibody-drug conjugates, compositions thereof, and methods use. The antibody-drug conjugates include a fusion protein comprising an antibody covalently linked to an ADP-ribosyl cyclase protein via a peptide linker moiety at one or more of a C-terminus or N-terminus of a heavy or light chain of the antibody, a NAD or NMN analogue, and a payload such that the NAD or NMN analogue is conjugated to both the payload and the ADP-ribosyl cyclase protein. |
| FILED | Monday, May 10, 2021 |
| APPL NO | 17/996313 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6807 (20170801) A61K 47/6815 (20170801) Original (OR) Class A61K 47/6851 (20170801) A61K 47/6889 (20170801) A61K 2039/505 (20130101) Peptides C07K 16/2851 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/2497 (20130101) Enzymes C12Y 302/02006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230128716 | MIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | WEI MIN (Edgewater, New Jersey); LU WEI (Anhui, China PRC); ZHIXING CHEN (Beijing, China PRC); FANGHAO HU (New York, New York); YIHUI SHEN (Jiangsu, China PRC) |
| ABSTRACT | Methods, systems and computer-accessible medium for imaging a living cell or a living organism with bond-edited compounds using stimulated Raman scattering are disclosed. The method comprises the steps of introducing one or more bond-edited compounds into a live cell or a living organism, and detecting a vibrational tag in the cell or organism with stimulated Raman scattering. Also disclosed are methods for detecting a disease condition in a subject, methods for monitoring treatment for a disease condition, methods for screening an agent, methods for tracing a cellular process in a live cell using bond-edited compounds in combination with stimulated Raman scattering. Also disclosed are a composition for labeling a target cell with at least one bond-edited compound and devices for imaging bond-edited compounds by stimulated Raman scattering. |
| FILED | Monday, August 08, 2022 |
| APPL NO | 17/882938 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/0013 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/583 (20130101) Original (OR) Class G01N 33/5005 (20130101) G01N 2021/655 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230128722 | Pamula et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Advanced Liquid Logic, Inc. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vamsee K. Pamula (Cary, North Carolina); Michael G. Pollack (Durham, North Carolina); Ramakrishna Sista (Cary, North Carolina); Arjun Sudarsan (Carlsbad, California) |
| ABSTRACT | Methods are provided for separating magnetically responsive beads from a droplet in a droplet actuator. Droplet operations electrodes and a magnet are arranged in a droplet actuator to manipulate a bead-containing droplet and position it relative to a magnetic field region that attracts the magnetically responsive beads. The droplet operations electrodes are operated to control the droplet shape and transport it away from the magnetic field region to form a concentration of beads in the droplet. The continued transport of the droplet away from the magnetic field causes the concentration of beads to break away from the droplet to yield a small, concentrated bead-containing droplet immobilized by the magnet. |
| FILED | Friday, December 09, 2022 |
| APPL NO | 18/063874 |
| CURRENT CPC | Mixing, e.g Dissolving, Emulsifying, Dispersing B01F 31/65 (20220101) B01F 33/3021 (20220101) B01F 33/3031 (20220101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 3/502761 (20130101) B01L 3/502784 (20130101) B01L 3/502792 (20130101) B01L 7/52 (20130101) Magnetic or Electrostatic Separation of Solid Materials From Solid Materials or Fluids; Separation by High-voltage Electric Fields B03C 1/02 (20130101) B03C 1/30 (20130101) B03C 1/288 (20130101) B03C 5/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1013 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/561 (20130101) G01N 33/54333 (20130101) Original (OR) Class Technical Subjects Covered by Former US Classification Y10T 436/25625 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230128742 | Walk et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California); Technische Universität Berlin (Berlin, Germany) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California); Technische Universität Berlin (Berlin, Germany) |
| INVENTOR(S) | Philipp Walk (Pasadena, California); Babak Hassibi (San Marino, California); Peter Jung (Berlin, Germany) |
| ABSTRACT | Systems and methods for transmitting data using various Modulation on Zeros schemes are described. In many embodiments, a communication system is utilized that includes a transmitter having a modulator that modulates a plurality of information bits to encode the bits in the zeros of the z-transform of a discrete-time baseband signal. In addition, the communication system includes a receiver having a decoder configured to decode a plurality of bits of information from the samples of a received signal by: determining a plurality of zeros of a z-transform of a received discrete-time baseband signal based upon samples from a received continuous-time signal, identifying zeros that encode the plurality of information bits, and outputting a plurality of decoded information bits based upon the identified zeros. |
| FILED | Thursday, June 02, 2022 |
| APPL NO | 17/805207 |
| CURRENT CPC | Multiplex Communication H04J 11/00 (20130101) H04J 2011/0096 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 25/0204 (20130101) H04L 27/2627 (20130101) Original (OR) Class H04L 27/2639 (20130101) H04L 27/2663 (20130101) H04L 27/26532 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230128967 | Zhao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for the State University of New York (Amherst, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ruogang Zhao (Amherst, New York); Chi Zhou (Getzville, New York) |
| ABSTRACT | A system, method, and computer program product that allows the additive manufacturing of a component from a build material held within a tank, such as the manufacture of a hydrogel biomemetic structure. The tank includes a window with a light source positioned adjacent the window. A build platform is within the tank and opposite the light source and an actuator is coupled to the build platform that movie the build platform within the tank and relative to the window. A computing device is operably coupled to the actuator and controls the operation of the actuator to build a component by positioning the build platform within the tank at predetermined distances from the window with the build platform at least partially submerged in any build material contained in the tank, and moving the build platform relative to the window and the light source thereby building a component. |
| FILED | Thursday, October 20, 2022 |
| APPL NO | 17/970052 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/124 (20170801) Original (OR) Class B29C 64/232 (20170801) B29C 64/245 (20170801) B29C 64/255 (20170801) B29C 64/264 (20170801) B29C 64/393 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 50/02 (20141201) B33Y 70/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230129271 | Nassar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Children's Hospital Medical Center (Cincinnati, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicolas Nassar (Cincinnati, Ohio); William Seibel (Liberty Township, Ohio); Anjelika Gasilina (Bethesda, Maryland); Jose Cancelas (Cincinnati, Ohio) |
| ABSTRACT | A small molecule compound IODVA1 has been found to have cellular inhibitory activity against several transformed cell lines including Ras-driven cells. IODVA1 decreases cell-cell and cell-extra cellular matrix interactions and reduces growth of Ras-driven tumors. Applicants also synthesized compound NIRA2 and showed in vitro and in vivo efficacy and potency against models of Ph+(BCR-ABL1) B-ALL and of colon adenocarcinoma xenografts. |
| FILED | Tuesday, December 13, 2022 |
| APPL NO | 18/080041 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/53 (20130101) A61K 31/444 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230129326 | OSTROV et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David A. OSTROV (Gainesville, Florida); Leah R. REZNIKOV (Gainesville, Florida); Michael NORRIS (Gainesville, Florida); Ashley Nicole BROWN (Orlando, Florida) |
| ABSTRACT | Methods of preventing or treating infection by a SARS-CoV-related betacoronavirus are described. The methods include administering to a patient at risk of being infected by a SARS-CoV-related betacoronavirus or suffering from SARS-CoV-related betacoronavirus-related illness a small molecule drug and/or an antibody that binds to the ACE2-SARS interaction domain of either ACE2 or SARS-CoV-2 spike protein. Also described are vaccines comprising S-protein polypeptides corresponding to the ACE-2 interaction domain. |
| FILED | Tuesday, April 06, 2021 |
| APPL NO | 17/995050 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/55 (20130101) A61K 31/135 (20130101) Original (OR) Class A61K 31/166 (20130101) A61K 31/495 (20130101) A61K 31/655 (20130101) A61K 31/4402 (20130101) A61K 31/5415 (20130101) A61K 39/215 (20130101) A61K 45/06 (20130101) A61K 2039/55566 (20130101) Peptides C07K 16/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230129381 | ZHU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE GEORGE WASHINGTON UNIVERSITY (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | WENGE ZHU (Germantown, Maryland); JING LI (Arlington, Virginia); YILIANG LI (Tianjin, China PRC) |
| ABSTRACT | Embodiments of the instant disclosure relate to novel methods and compositions for treating tumors resistant to one or more anticancer drugs, such as platinum-based chemotherapeutics. |
| FILED | Wednesday, September 14, 2022 |
| APPL NO | 17/944506 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/69 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 311/02 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/025 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230129475 | RAJARAMAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Swaminathan RAJARAMAN (Winter Park, Florida); Charles M. DIDIER (Dunedin, Florida); Julia FREITAS ORRICO (Orlando, Florida) |
| ABSTRACT | A three-dimensional (3D) microelectrode array device for in vitro electrophysiological applications includes a substrate and micro vias extending from the bottom face to the top face of the substrate. A microneedle at each micro via extends from the bottom face upward beyond the top face and forms a hypodermic microneedle array on the top face. Metallic traces on the bottom face interconnect the hypodermic microneedles to form the 3D microelectrode array. A microheater is positioned on the bottom face of the substrate. Microfluidic ports may be formed at the substrate. Interdigitated electrodes may be formed at the substrate. |
| FILED | Thursday, October 13, 2022 |
| APPL NO | 18/046161 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) Original (OR) Class C12M 23/16 (20130101) C12M 25/02 (20130101) C12M 41/12 (20130101) C12M 41/46 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230129517 | Ma et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ning Ma (Oakland, California); Michelle Digman (Oakland, California); Hongtao Chen (Oakland, California) |
| ABSTRACT | A system for determining the viability of an embryo comprises an imaging device, an excitation device configured to direct an excitation energy at an embryo, a controller communicatively connected to the imaging device and the excitation device, configured to drive the excitation device and collect images from the imaging device at an imaging frequency, a processor performing steps comprising acquiring a set of images from the imaging device, performing a Fourier Transformation to generate a set of phasor coordinates, computing a D-trajectory, computing a set of values of additional parameters, comparing the set of values to a set of stored values related to embryos of known viability, and calculating a viability index factor of the embryo from the set of values and the set of stored values. Methods of calculating embryo viability and determining one or more properties of a tissue are also described. |
| FILED | Monday, July 11, 2022 |
| APPL NO | 17/811743 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6486 (20130101) G01N 33/5005 (20130101) Image Data Processing or Generation, in General G06T 7/0014 (20130101) Original (OR) Class G06T 7/66 (20170101) G06T 2207/10056 (20130101) G06T 2207/10064 (20130101) G06T 2207/20056 (20130101) G06T 2207/30024 (20130101) G06T 2207/30044 (20130101) Pictorial Communication, e.g Television H04N 5/2256 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230129745 | STEPHENS |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jacqueline STEPHENS (Baton Rouge, Louisiana) |
| ABSTRACT | This invention is directed to compounds, compositions, and methods to treat metabolic diseases. For example, the invention is drawn to compounds identified in extracts from Artemisia scoparia for the treatment of metabolic disease. |
| FILED | Monday, February 08, 2021 |
| APPL NO | 17/760093 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 36/282 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/04 (20180101) Acyclic or Carbocyclic Compounds C07C 39/04 (20130101) Original (OR) Class C07C 39/19 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230129789 | Puri et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ohio University (Athens, Ohio) |
| ASSIGNEE(S) | Ohio University (Athens, Ohio) |
| INVENTOR(S) | Vishwajeet Puri (Athens, Ohio); John Kopchick (Athens, Ohio); Vishva Sharma (Athens, Ohio) |
| ABSTRACT | Methods and FSP27 compositions for treating and/or preventing metabolic disease and conditions associated insulin resistance, obesity, inflammation and dyslipidemia are described. |
| FILED | Tuesday, July 26, 2022 |
| APPL NO | 17/873386 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 38/1709 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/00 (20180101) A61P 3/06 (20180101) A61P 3/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230130102 | XIE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Marshall University Research Corporation (Huntington, West Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zijian XIE (Huntington, West Virginia); Moumita BANERJEE (Huntington, West Virginia); Joseph SHAPIRO (Huntington, West Virginia); Yingnyu GAO (Huntington, West Virginia); Maosheng DUAN (Huntington, West Virginia); Xuchai TAN (Huntington, West Virginia) |
| ABSTRACT | Na/K-ATPase ligands are provided that comprise a compound of formula (I) and are capable of binding to the α1 Na/K-ATPase and decreasing the endocytosis of α1 Na/K-ATPase, such that expression of the α1 Na/K-ATPase is restored in the plasma membrane of cells and tumor growth and invasion is reduced. Pharmaceutical compositions are further provided that include a compound of formula (I) and a pharmaceutically-acceptable vehicle, carrier, or excipient. Methods of treating a cancer are further included and comprise administering to a subject an effective amount of a Na/K-ATPase ligand. |
| FILED | Thursday, October 08, 2020 |
| APPL NO | 17/767276 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 13/08 (20180101) A61P 35/00 (20180101) A61P 35/04 (20180101) Acyclic or Carbocyclic Compounds C07C 49/83 (20130101) C07C 49/84 (20130101) Heterocyclic Compounds C07D 311/86 (20130101) Original (OR) Class C07D 327/08 (20130101) C07D 491/147 (20130101) C07D 498/04 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/65522 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230130218 | WISNIEWSKI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NEW YORK UNIVERSITY (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas M. WISNIEWSKI (Staten Island, New York); Fernando GONI (New York, New York) |
| ABSTRACT | The present invention is directed to polymerized products and compositions useful for the treatment and prevention of amyloid disease in a subject. The invention further relates to isolated antibodies that recognize a common conformational epitope of amyloidogenic proteins or peptides that are useful for the diagnosis, treatment, and prevention of amyloid disease. |
| FILED | Friday, May 13, 2022 |
| APPL NO | 17/743854 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0056 (20130101) A61K 39/0007 (20130101) A61K 2039/64 (20130101) A61K 2039/523 (20130101) Peptides C07K 14/4711 (20130101) Original (OR) Class C07K 16/18 (20130101) C07K 2317/20 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) G01N 2333/4709 (20130101) G01N 2800/28 (20130101) G01N 2800/2821 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230130243 | Apolo |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as Represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrea B. Apolo (Bethesda, Maryland) |
| ABSTRACT | The present disclosure relates to a method of treating urothelial carcinoma using Cabozantinib, a kinase inhibitor. |
| FILED | Tuesday, November 29, 2022 |
| APPL NO | 18/059840 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/47 (20130101) Original (OR) Class A61K 39/3955 (20130101) A61K 2039/507 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230130325 | PUSKARICH et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael A. PUSKARICH (Jackson, Mississippi); ALAN E. JONES (Jackson, Mississippi); CHRISTOPHER E. GILLIES (Ann Arbor, Michigan); THEODORE S. JENNARO (Ann Arbor, Michigan); KATHLEEN A. STRINGER (Ann Arbor, Michigan) |
| ABSTRACT | Provided herein is technology relating to treating septic shock and particularly, but not exclusively, to methods and systems for identifying sepsis patients most likely to benefit from L-carnitine treatment. |
| FILED | Tuesday, March 30, 2021 |
| APPL NO | 17/915392 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/205 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/68 (20130101) G01N 2800/26 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230130372 | ZHANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas); THE GEORGE WASHINGTON UNIVERSITY (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ningyan ZHANG (Houston, Texas); Zhiqiang AN (Houston, Texas); Hui DENG (Houston, Texas); Xiujie SUN (Washington, District of Columbia); Rong LI (Washington, District of Columbia) |
| ABSTRACT | The present disclosure relates to antibodies binding to tumor discoidin domain receptor 1 (DDR1) and the uses of the antibodies in detecting and treating cancer. Thus, in one aspect, the present disclosure provides an isolated monoclonal antibody or an antigen-binding fragment thereof that binds specifically to DDR1. In certain embodiments, the antibody or antigen-binding fragment, when bound to DDR1, modulates the activity of DDR1, i.e., suppresses DDR1. |
| FILED | Thursday, December 17, 2020 |
| APPL NO | 17/757510 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2896 (20130101) Original (OR) Class C07K 2317/20 (20130101) C07K 2317/565 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230130579 | Paul et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNM Rainforest Innovations (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Surojit Paul (Albuquerque, New Mexico); Ranjana Poddar (Albuquerque, New Mexico) |
| ABSTRACT | A method for the prevention, treatment, or amelioration of a medical disease or condition associated with inflammation caused by glutamate excitotoxicity comprising administering to a patient a peptide that binds to or interferes with the P38 MAPK-COX2-PGE2 and ERK MAPK-CX3CL1-sCX3CL1 pathways. |
| FILED | Monday, February 01, 2021 |
| APPL NO | 17/759864 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/465 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/16 (20130101) Enzymes C12Y 301/03048 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230130602 | Abel-Santos et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ernesto Abel-Santos (Las Vegas, Nevada); Steven Firestine (Livonia, Michigan); Shiv Sharma (Canton, Michigan); Angel Schilke (Saline, Michigan); Chris Yip (Emeryville, California); Jacqueline Phan (Las Vegas, Nevada) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ernesto Abel-Santos (Las Vegas, Nevada); Steven Firestine (Livonia, Michigan); Shiv Sharma (Canton, Michigan); Angel Schilke (Saline, Michigan); Chris Yip (Emeryville, California); Jacqueline Phan (Las Vegas, Nevada) |
| ABSTRACT | Provided herein are compounds, compositions, and methods useful for reducing, preventing, and/or inhibiting germination of C. difficile spores, including methods for inhibiting C. difficile germination to prevent or treating C. difficile-associated diseases and disorders such as, for example, severe diarrhea and colitis in a subject. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| FILED | Friday, September 09, 2022 |
| APPL NO | 17/941611 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/16 (20130101) A61K 31/575 (20130101) Original (OR) Class A61K 47/06 (20130101) A61K 47/551 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230130686 | Sharei et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Armon R. Sharei (Cambridge, Massachusetts); Andrea Adamo (Cambridge, Massachusetts); Robert S. Langer (Newton, Massachusetts); Klavs F. Jensen (Lexington, Massachusetts) |
| ABSTRACT | A microfluidic system for causing perturbations in a cell membrane, the system including a microfluidic channel defining a lumen and being configured such that a cell suspended in a buffer can pass therethrough, wherein the microfluidic channel includes a cell-deforming constriction, wherein a diameter of the constriction is a function of the diameter of the cell. |
| FILED | Monday, October 25, 2021 |
| APPL NO | 17/509229 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/16 (20130101) Original (OR) Class C12M 35/02 (20130101) C12M 35/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230130766 | COSFORD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SALK INSTITUTE FOR BIOLOGICAL STUDIES (La Jolla, California); SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas D.P. COSFORD (La Jolla, California); Reuben J. SHAW (La Jolla, California); Nicole A. BAKAS (La Jolla, California); Allison S. LIMPERT (La Jolla, California); Sonja N. BRUN (La Jolla, California); Mitchell VAMOS (La Jolla, California) |
| ABSTRACT | Provided herein are methods of treating diseases, including cancer, with ULK inhibitors, both as monotherapies and in combination with other therapeutic agents. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/799641 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/506 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230130791 | Habib |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amyn A. Habib (Dallas, Texas) |
| ABSTRACT | The present disclosure is concerned with modulators of EGFR and modulators of Nrf2 for treating various cancers such as, for example, sarcomas, carcinomas, hematological cancers, solid tumors, breast cancer, cervical cancer, gastrointestinal cancer, colorectal cancer, brain cancer, skin cancer, prostate cancer, ovarian cancer, bladder cancer, thyroid cancer, testicular cancer, pancreatic cancer, endometrial cancer, melanomas, gliomas, leukemias, lymphomas, chronic myeloproliferative disorders, myelodysplastic syndromes, myeloproliferative neoplasms, and plasma cell neoplasms (myelomas). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| FILED | Wednesday, March 10, 2021 |
| APPL NO | 17/910637 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/44 (20130101) A61K 31/427 (20130101) A61K 31/517 (20130101) Original (OR) Class A61K 31/655 (20130101) A61K 31/4409 (20130101) A61K 39/3955 (20130101) A61K 2039/545 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230131140 | Yadav et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of South Florida (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hariom Yadav (Tampa, Florida); Shalinie Jain (Tampa, Florida); Sidharth Mishra (Tampa, Florida) |
| ABSTRACT | The present disclosure provides for a method of treating increased gut permeability, including administering a therapeutically effective amount of a human-derived probiotic to a patient in need thereof. Further provided herein is a method of increasing a patient's metabolism of ethanolamine, including administering a therapeutically effective amount of human derived probiotics to the patient in need thereof. Also provided herein is a pharmaceutical composition, including a first strain of Lactobacillus and a second probiotic strain. The present disclosure also provides for a pharmaceutical composition, including Lactobacillus and an antidiabetic drug. Additionally, provided herein is a pharmaceutical composition, including Lactobacillus and a weight management drug. |
| FILED | Wednesday, October 26, 2022 |
| APPL NO | 17/973909 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/747 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230131219 | Serody et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina); The United States of America, as Represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan Serody (Chapel Hill, North Carolina); Nicholas P. Restifo (Chevy Chase, Maryland); Nuo Xu (Chapel Hill, North Carolina) |
| ABSTRACT | Disclosed herein is a chimeric antigen receptor T cell therapy for treating patients having a cancer, such as a cancer having one or more solid tumors. |
| FILED | Monday, November 09, 2020 |
| APPL NO | 17/775262 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/352 (20130101) A61K 35/17 (20130101) Original (OR) Class A61K 38/177 (20130101) A61K 38/1774 (20130101) A61K 39/3955 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230131243 | Hildeman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CHILDREN'S HOSPITAL MEDICAL CENTER (Cincinnati, Ohio) |
| ASSIGNEE(S) | CHILDREN'S HOSPITAL MEDICAL CENTER (Cincinnati, Ohio) |
| INVENTOR(S) | David A. Hildeman (Cincinnati, Ohio); Andrew Herr (Cincinnati, Ohio); Suhas G. Kallapur (Cincinnati, Ohio); Jarek Meller (Cincinnati, Ohio); Alexander Thorman (Cincinnati, Ohio) |
| ABSTRACT | The disclosure provides methods of modulating an immune response by inhibiting BFL1, and related methods for treating and preventing diseases and disorders characterized by inflammation, especially neutrophil induced inflammation. |
| FILED | Monday, December 19, 2022 |
| APPL NO | 18/083617 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/127 (20130101) A61K 31/655 (20130101) A61K 31/713 (20130101) Original (OR) Class A61K 31/7105 (20130101) Peptides C07K 16/18 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2310/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230131376 | MELANDER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Christian MELANDER (South Bend, Indiana); Bradley M. MINROVIC (South Bend, Indiana); University of Notre Dame du Lac (South Bend, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christian MELANDER (South Bend, Indiana); Bradley M. MINROVIC (South Bend, Indiana) |
| ABSTRACT | Tryptamine ureas and derivatives function as adjuvants to sensitize gram-negative bacteria to the effects of polymyxin antibiotics (e.g., colistin). Combination therapy of polymyxin antibiotics and the adjuvants has utility in the treatment of gram-negative bacterial infection, including treatment of drug-resistant strains. |
| FILED | Thursday, April 16, 2020 |
| APPL NO | 17/908506 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4045 (20130101) A61K 38/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230131501 | XU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Kansas (Lawrence, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Liang XU (Lawrence, Kansas); Xiaoqing WU (Lawrence, Kansas); Lan LAN (Lawrence, Kansas); Jeff Aube (Chapel Hill, Kansas) |
| ABSTRACT | The present technology is directed to methods of treatment utilizing inhibitors of HuR interaction with RNA, where the inhibitors are of Formula I where R1 is; and X1 is OH, NH—OH, or 0-(C1-C8 unsubstituted alkyl). |
| FILED | Monday, March 22, 2021 |
| APPL NO | 17/914287 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/337 (20130101) A61K 31/381 (20130101) Original (OR) Class A61K 31/704 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/18 (20180101) A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230131668 | Wipf et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter Wipf (Pittsburgh, Pennsylvania); Linh Khai Ngo (Pittsburgh, Pennsylvania); Leila Terrab (Pittsburgh, Pennsylvania); Jeffrey L. Brodsky (Pittsburgh, Pennsylvania) |
| ABSTRACT | Disclosed are thiadiazine compounds, derivatives and compositions thereof. The compounds, derivatives, and compositions can be used for treating or preventing a heat-shock protein responsive disorder or suppressing protein aggregation in a subject. The compounds and compositions can also be used for treating cancer, neurodegenerative disorders, and other heat-shock protein responsive disorders. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/798699 |
| CURRENT CPC | Heterocyclic Compounds C07D 285/16 (20130101) Original (OR) Class C07D 417/12 (20130101) C07D 513/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230131867 | GIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SLOAN KETTERING INSTITUTE FOR CANCER RESEARCH (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David GIN (New York, New York); Michelle ADAMS (Waterville, Ohio); Kai DENG (Guilderland, New York); Philip LIVINGSTON (New York, New York); Govindaswami RAGUPATHI (New York, New York); Eric CHEA (Flushing, New York); Alberto FERNANDEZ-TEJADA (New York, New York); Lars Ulrik NORDSTROEM (New York, New York); William WALKOWICZ (Brooklyn, New York); Jeffrey GARDNER (New York, New York); Derek TAN (New York, New York) |
| ABSTRACT | The present invention relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, intermediates thereto, and uses thereof. QS-7 is a potent immuno-adjuvant that is significantly less toxic than QS-21, a related saponin that is currently the favored adjuvant in anticancer and antiviral vaccines. Tedious isolation and purification protocols have hindered the clinical development of QS-7. A novel semi-synthetic method is provided wherein a hydrolyzed prosapogenin mixture is used to synthesize QS-7, QS-21, and related analogs, greatly facilitating access to QS-7 and QS-21 analogs for preclinical and clinical evaluation. |
| FILED | Monday, September 19, 2022 |
| APPL NO | 17/947716 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/704 (20130101) A61K 31/7024 (20130101) A61K 39/385 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 13/08 (20130101) C07H 15/24 (20130101) C07H 15/256 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230131972 | Church et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George M. Church (Brookline, Massachusetts); Prashant G. Mali (La Jolla, California); Kevin M. Esvelt (Auburndale, Massachusetts) |
| ABSTRACT | Methods of modulating expression of a target nucleic acid in a cell are provided including introducing into the cell a first foreign nucleic acid encoding one or more RNAs complementary to DNA, wherein the DNA includes the target nucleic acid, introducing into the cell a second foreign nucleic acid encoding a nuclease-null Cas9 protein that binds to the DNA and is guided by the one or more RNAs, introducing into the cell a third foreign nucleic acid encoding a transcriptional regulator protein or domain, wherein the one or more RNAs, the nuclease-null Cas9 protein, and the transcriptional regulator protein or domain are expressed, wherein the one or more RNAs, the nuclease-null Cas9 protein and the transcriptional regulator protein or domain co-localize to the DNA and wherein the transcriptional regulator protein or domain regulates expression of the target nucleic acid. |
| FILED | Tuesday, October 25, 2022 |
| APPL NO | 17/972885 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/102 (20130101) C12N 15/113 (20130101) C12N 15/635 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2310/3513 (20130101) Enzymes C12Y 301/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230132012 | Schaffer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David K. Schaffer (Nashville, Tennessee); John P. Wikswo (Brentwood, Tennessee); Ronald S. Reiserer (Nashville, Tennessee); Michael D. Geuy (Nashville, Tennessee); Eric C. Spivey (Nashville, Tennessee); Clayton M. Britt (Franklin, Kentucky); Jacquelyn A. Brown (Nashville, Tennessee); Dmitry A. Markov (Nashville, Tennessee); Shannon Faley (Nashville, Tennessee); Lisa J. McCawley (Nashville, Tennessee); Philip C. Samson (Nashville, Tennessee) |
| ABSTRACT | One aspect of this invention relates to a vertical-via rotary valve including a valve body having a housing; one or more fluidic channels, each fluidic channel having a vertical channel portion defined in the valve body and being adjacent to the housing, wherein a fluid flow through the vertical channel portion is controllable by deforming a sidewall of the vertical channel portion; and an actuator received in the housing and rotatably engaged with the one or more fluidic channels to operably control the fluid flow through the vertical channel portion of each fluid channel. |
| FILED | Friday, April 30, 2021 |
| APPL NO | 17/917963 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 3/502738 (20130101) Original (OR) Class B01L 2200/0605 (20130101) B01L 2300/123 (20130101) B01L 2300/0803 (20130101) B01L 2300/0816 (20130101) B01L 2300/0858 (20130101) B01L 2300/0861 (20130101) B01L 2400/0481 (20130101) B01L 2400/0644 (20130101) B01L 2400/0655 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230132035 | Yin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hang Hubert Yin (Boulder, Colorado); Shuting Zhang (Boulder, Colorado); Zhenyi Hu (Boulder, Colorado) |
| ABSTRACT | Toll-like receptor 8 (TLR8)-specific inhibitors and methods of using the same in individuals having an autoimmune disease or an inflammatory disorder. |
| FILED | Monday, October 10, 2022 |
| APPL NO | 17/962656 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/02 (20180101) A61P 37/06 (20180101) Heterocyclic Compounds C07D 215/20 (20130101) C07D 401/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230132184 | M'Saad |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ons M'Saad (New Haven, Connecticut) |
| ABSTRACT | Methods and systems for physical expansion and imaging of biological samples are described herein. In one aspect of the disclosure, a method for preparing a biological sample for the purpose of generating images of its ultrastructure with an imaging instrument includes a) physically expanding the sample by at least a factor of two in at least one dimension; and b) bulk labeling a plurality of components of the sample with at least one reagent to introduce contrast. |
| FILED | Friday, March 12, 2021 |
| APPL NO | 17/905864 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/04 (20130101) G01N 21/17 (20130101) G01N 33/4833 (20130101) Original (OR) Class G01N 2021/1765 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230132279 | Lencer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Children's Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | Children's Medical Center Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Wayne I. Lencer (Jamaica Plain, Massachusetts); Daniel JF Chinnapen (Quincy, Massachusetts) |
| ABSTRACT | Provided herein, in some aspects, are delivery vehicles comprising a glycosphingolipid and an agent to be delivered attached to the glycosphingolipid. In some embodiments, the glycosphingolipid comprises an oligosaccharide and a short chain (e.g., C0-C3) ceramide. In some embodiments, the agent to be delivered is a therapeutic agent. The glycosphingolipid is able to deliver the agent to a cell or to a cellular compartment, as well as across the musical barrier. In some embodiments, agents delivered using the glycosphingolipid described herein exhibit longer half-life, compared to agents delivered alone. Methods of delivering a therapeutic agent to a subject for treating a disease using the glycosphingolipid delivery vehicle are also provided. |
| FILED | Thursday, December 22, 2022 |
| APPL NO | 18/087273 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/22 (20130101) A61K 38/26 (20130101) Original (OR) Class A61K 39/00 (20130101) A61K 39/395 (20130101) A61K 47/54 (20170801) A61K 47/549 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230132281 | MONAGHAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | RHODE ISLAND HOSPITAL (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sean F. MONAGHAN (East Greenwich, Rhode Island); Alger M. FREDERICKS (East Providence, Rhode Island) |
| ABSTRACT | Deep RNA sequencing is a technology that provides an initial diagnostic for sepsis that can also monitor the indicia of treatment and recovery (bacterial counts reduce, physiology returns to steady-state). The invention can be used for many other hospital conditions, particularly those needing an intensive care unit stay with the attendant risk of bacterial infection, such as trauma, stroke, myocardial infarction, or major surgery. |
| FILED | Tuesday, February 16, 2021 |
| APPL NO | 17/760490 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) Original (OR) Class C12Q 1/6883 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 30/00 (20190201) G16B 40/30 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230132355 | Ildefonso et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cristhian J. Ildefonso (Gainesville, Florida); Alfred S. Lewin (Gainesville, Florida); Qiuhong Li (Gainesville, Florida) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| INVENTOR(S) | Cristhian J. Ildefonso (Gainesville, Florida); Alfred S. Lewin (Gainesville, Florida); Qiuhong Li (Gainesville, Florida) |
| ABSTRACT | The present invention provides methods and compositions for treating and/or preventing age related macular degeneration and other conditions involving macular degeneration, ocular neovascularization, or ocular inflammation. In an exemplary embodiment, a method is disclosed that involves administering an expression vector that delivers a secretable and cell penetrating CARD to a subject in need of treatment or prevention of age-related macular degeneration or another condition involving macular degeneration or ocular neovascularization. |
| FILED | Wednesday, March 17, 2021 |
| APPL NO | 17/204627 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 48/005 (20130101) Peptides C07K 14/4703 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2750/14141 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230132381 | CUI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | XINYAN CUI (Wexford, Pennsylvania); BIN CAO (Berwyn, Pennsylvania) |
| ABSTRACT | A method of forming a compound having the formula: includes the reaction: n the presence of a base comprising teat-butyl lithium, lithium diisopropylamide, sodium hydroxide, potassium hydroxide, lithium hydroxide, a potassium alkoxide or a sodium alkoxide to achieve a yield of at least 90%, wherein X is a halo atom selected from the group consisting of Cl, Br and I. |
| FILED | Tuesday, October 26, 2021 |
| APPL NO | 17/510819 |
| CURRENT CPC | Heterocyclic Compounds C07D 495/04 (20130101) Original (OR) Class Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 2/58 (20130101) C08F 28/06 (20130101) C08F 2400/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230132397 | Dowling et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Children's Medical Center Corporation (Boston, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Children's Medical Center Corporation (Boston, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | David J. Dowling (Brighton, Massachusetts); Ofer Levy (Cambridge, Massachusetts); Francesco Borriello (Jamaica Plain, Massachusetts); David A. Scott (Newton, Massachusetts); Spencer E. Brightman (San Diego, California) |
| ABSTRACT | Provided herein are Toll-like receptor 2 (TLR2) agonists for use in enhancing human immune response and/or as adjuvants in vaccines. The TLR2 agonists include thiophenes, imidazoles, or phenyl-containing compounds, which may be compounds of Formulae (I), (II), (III), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. The compounds described herein are used as enhancers of an immune response (e.g., innate and/or adaptive immune response), and are useful in treating and/or preventing a disease, as adjuvants in a vaccine for the disease, (e.g., proliferative disease, inflammatory disease, autoimmune disease, infectious disease, or chronic disease). Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a compound described herein. |
| FILED | Friday, July 26, 2019 |
| APPL NO | 17/263515 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/381 (20130101) A61K 31/438 (20130101) A61K 31/496 (20130101) A61K 31/739 (20130101) A61K 31/4025 (20130101) A61K 31/4535 (20130101) A61K 39/39 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 2039/572 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20230125162 | Kong et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | U.S. Army Combat Capabilities Development Command, Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Justin S. Kong (Clarksville, Maryland); Fikadu T. Dagefu (Silver Spring, Maryland); Brian M. Sadler (Laurel, Maryland) |
| ABSTRACT | Systems and methods for wireless communications comprising a plurality of agents, which together as the group, are configured to: (i) wirelessly broadcast an interference signal by forming a radiation pattern having null vectored substantially toward a client; (ii) wirelessly transmit a communication signal to the client by forming a radiation beam carrying the communication signal vectored substantially toward the client; and (iii) wirelessly broadcast a combined communication signal and interference signal to the client using phases of processes (i) and (ii). In some embodiments, the agents together as a group may be further configured to: allocate and adjust power for performing processes (i) and (ii) at substantially the same time. |
| FILED | Wednesday, May 05, 2021 |
| APPL NO | 17/308498 |
| CURRENT CPC | Transmission H04B 7/0617 (20130101) Original (OR) Class H04B 7/0632 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230125317 | Zheng et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of Chicago (Chicago, Illinois); The University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jiyuan Zheng (Lisle, Illinois); Supratik Guha (Chicago, Illinois); Joe C. Campbell (Charlottesville, Virginia) |
| ABSTRACT | This disclosure is directed to a high-speed avalanche photodiode device configured to detect single photons. The avalanche photodiode device may include a passive quenching circuitry. The passive quenching circuitry may include a quenching resistor having a resistivity spontaneously adaptive to a bias voltage applied across the quenching resistor. Such adaptive resistivity enables a fast response time for the avalanche photodiode device when used to detect single photos in Geiger mode. |
| FILED | Tuesday, March 02, 2021 |
| APPL NO | 17/801695 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/02027 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230125788 | Miller et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Timothy Miller (St. Louis, Missouri); Hunter Patterson (St. Louis, Missouri); Kathleen Schoch (St. Louis, Missouri); Yuna Ayala (St. Louis, Missouri); Zachary Grese (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri); Saint Louis University (St. Louis, Missouri) |
| INVENTOR(S) | Timothy Miller (St. Louis, Missouri); Hunter Patterson (St. Louis, Missouri); Kathleen Schoch (St. Louis, Missouri); Yuna Ayala (St. Louis, Missouri); Zachary Grese (St. Louis, Missouri) |
| ABSTRACT | Among the various aspects of the present disclosure is the provision of a method of treating a neurodegenerative disease in a subject in need thereof comprising administering a therapeutically effective amount of a TAR DNA-binding protein (TDP-43) modulating agent comprising an RNA oligonucleotide. |
| FILED | Wednesday, October 26, 2022 |
| APPL NO | 18/049903 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6811 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230126296 | Brattain et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Laura J. Brattain (Lexington, Massachusetts); Anthony E. Samir (Newton, Massachusetts); Brian A. Telfer (Lincoln, Massachusetts); Matthew Johnson (Medford, Massachusetts); Nancy DeLosa (Westford, Massachusetts); Lars Gjesteby (Maynard, Massachusetts); Theodore T. Pierce (Auburndale, Massachusetts); Joshua Werblin (Boston, Massachusetts) |
| ABSTRACT | Systems and methods are provided for semi-automated, portable, ultrasound guided cannulation. The systems and methods provide for image analysis to provide for segmentation of vessels of interest from image data. The image analysis provides for guidance for insertion of a cannulation system into a subject which may be accomplished by a non-expert based upon the guidance provided. The guidance may include an indicator or a mechanical guide to guide a user for inserting the vascular cannulation system into a subject to penetrate the vessel of interest. |
| FILED | Friday, October 21, 2022 |
| APPL NO | 17/971073 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/08 (20130101) Original (OR) Class A61B 8/12 (20130101) A61B 8/0841 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230126388 | Coretto et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | August M. Coretto (Windsor, Connecticut); Scott W. Simpson (Feeding Hills, Massachusetts); Donald E. Army (Enfield, Connecticut); Peter J. Dowd (Granby, Connecticut); David J. Zawilinski (W. Granby, Connecticut) |
| ABSTRACT | An inline valve includes a sliding piston having a radially outer stop portion with a forward end. A radially inner sliding portion is connected to the radially outer stop portion by an arm. A housing includes an outer housing body surrounding the piston. The housing has a stop surface selectively in contact with the forward end of the radially outer stop portion of the piston to block flow for a housing inlet to a housing outlet. The radially inner sliding portion slides on a support tube. At least a portion of the radially inner sliding portion is formed of a first material having better wear resistance than a second material forming the outer stop portion of the piston. The second material has a greater resistance to high temperature and pressure than the first material. A vent valve for a compressor is also disclosed. |
| FILED | Friday, October 22, 2021 |
| APPL NO | 17/508485 |
| CURRENT CPC | Non-positive-displacement Pumps F04D 27/023 (20130101) F04D 27/0215 (20130101) Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 1/126 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230126905 | FISCHER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | INCUBE LABS, LLC (San Jose, California) |
| ASSIGNEE(S) | INCUBE LABS, LLC (San Jose, California) |
| INVENTOR(S) | Elmar FISCHER (Boerne, Texas); Charles Gregory NELSON (New Braunfels, Texas); Paul SPEHR (San Antonio, Texas); Kenneth R. COSGROVE (San Jose, California) |
| ABSTRACT | A header lock assembly includes a header lock pin and mating lead lock collar that provide a releasable coupling for attaching one or more leads to a device. The header lock assembly is configured to engage the lead to assure closure while not applying undue pressure on the lead. One or more notches in the header lock pin allow the lead to pass the header lock pin unimpeded while the header lock assembly is in an unlocked configuration. Rotation of the header lock pin engages a circumferential groove in the lead lock collar to secure the lead to the header. A slot in the top of the header lock pin provides an interface surface with a lead locking tool for rotating the header lock pin. The slot orientation provides a visual indication of the header lock assembly being in a locked or unlocked configuration. |
| FILED | Wednesday, January 27, 2021 |
| APPL NO | 17/915280 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/3752 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230127008 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David R. Liu (Cambridge, Massachusetts); Wei Hsi Yeh (Cambridge, Massachusetts) |
| ABSTRACT | The disclosure provides adenosine deaminases that are capable of deaminating adenosine in DNA to treat cancers, such as melanoma and glioblastoma. The disclosure also provides fusion proteins, guide RNAs and compositions comprising a Cas9 (e.g., a Cas9 nickase) domain and adenosine deaminases that deaminate adenosine in DNA, for example in a STAT3 gene. In some embodiments, adenosine deaminases provided herein are used to modify the STAT3 gene so that its protein product, STAT3, is unable to be activated. In some embodiments, the methods and compositions provided herein are used to treat melanoma or glioblastoma. |
| FILED | Wednesday, March 10, 2021 |
| APPL NO | 17/910552 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/495 (20130101) A61K 31/7105 (20130101) A61K 38/465 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/00 (20180101) A61P 25/00 (20180101) A61P 35/00 (20180101) Peptides C07K 2319/09 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/78 (20130101) C12N 15/11 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2800/80 (20130101) Enzymes C12Y 305/04004 (20130101) C12Y 305/04005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230127014 | Speyer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert F. Speyer (Atlanta, Georgia); Joseph Eun (Atlanta, Georgia) |
| ABSTRACT | An exemplary embodiment of the present disclosure provides a method for manufacturing a transparent ceramic material. The method comprises providing a compact comprising a metal oxide and, during sintering, exposing the compact to a vapor comprising one of or both fluorine ions and lithium ions to form a transparent ceramic material comprising at least 90% of a theoretical transparency. |
| FILED | Wednesday, October 19, 2022 |
| APPL NO | 18/048008 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/6268 (20130101) Original (OR) Class C04B 35/62655 (20130101) C04B 41/0072 (20130101) C04B 2235/77 (20130101) C04B 2235/662 (20130101) C04B 2235/6587 (20130101) C04B 2235/9653 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230127031 | Friedenberg et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David A. Friedenberg (Worthington, Ohio); Adam V. Rich (Columbus, Ohio); Michael R. Riedl (Worthington, Ohio); Jordan L. Vasko (Columbus, Ohio); Sanjay M. Tamrakar (Hilliard, Ohio) |
| ABSTRACT | In an approach to neural interface systems, a system includes feature extraction circuitry to identify one or more features of one or more input signals; and neural processing circuitry. The neural processing circuitry is configured to: identify a first context of a plurality of contexts based on a first trigger event; decode the one or more features of the one or more input signals to determine a first task of a plurality of tasks in the first context; and responsive to detecting a second trigger event, change the first context to a second context of the plurality of contexts. |
| FILED | Friday, October 21, 2022 |
| APPL NO | 18/048531 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/015 (20130101) Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230127768 | Cai et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GLOBALFOUNDRIES Singapore Pte. Ltd. (Singapore, Singapore) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xinshu Cai (Singapore, Singapore); Shyue Seng Tan (Singapore, Singapore); Vibhor Jain (Williston, Vermont); John J. Pekarik (Underhill, Vermont); Kien Seen Daniel Chong (Singapore, Singapore); Yung Fu Chong (Singapore, Singapore); Judson R. Holt (Ballston Lake, New York); Qizhi Liu (Lexington, Massachusetts); Kenneth J. Stein (Sandy Hook, Connecticut) |
| ABSTRACT | The present disclosure relates to semiconductor structures and, more particularly, to transistor with wrap-around extrinsic base and methods of manufacture. The structure includes: a substrate; a collector region within the substrate; an emitter region over the substrate and which comprises mono-crystal silicon based material; an intrinsic base under the emitter region and comprising semiconductor material; and an extrinsic base surrounding the emitter and over the intrinsic base. |
| FILED | Monday, October 25, 2021 |
| APPL NO | 17/509604 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/45 (20130101) H01L 29/1004 (20130101) H01L 29/7371 (20130101) Original (OR) Class H01L 29/66242 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230127827 | Menon et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Utah Research Foundation (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rajesh Menon (Salt Lake City, Utah); Apratim Majumder (Salt Lake City, Utah); Monjurul Feeroz Meem (Salt Lake City, Utah) |
| ABSTRACT | A Broadband Diffractive-Optical Element (BDOE) as a lens whose f-number and numerical aperture are decoupled. The BDOE can include a substrate and an array of optical cells formed on the substrate to have a non-linear arrangement of cell heights to diffract light into a focal spot. The geometry of the focal spot can be designed to decouple the f-number from the numerical aperture for an imaging device that employs the broadband diffractive optical element as a lens. |
| FILED | Monday, August 02, 2021 |
| APPL NO | 17/391309 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 27/0012 (20130101) G02B 27/4205 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230127861 | Madala |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Children's Hospital Medical Center (Cincinnati, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Satish Kumar Madala (Cincinnati, Ohio) |
| ABSTRACT | Disclosed herein are methods for treating an individual having, or at risk of having, pulmonary fibrosis, wherein volasertib, a salt thereof, or hydrate thereof, is administered to the individual in need thereof. In one aspect, the pulmonary fibrosis may be idiopathic pulmonary fibrosis. The volasertib may be administered in an amount and for a duration of time effective to achieve one or more outcomes selected from decreased invasiveness of pulmonary fibroblasts, increased clearance of myofibroblasts, decreased migration of pulmonary fibroblasts, decreased pulmonary fibroblast proliferation, decreased cell adhesion of pulmonary fibroblasts, decreased myofibroblast activation, decreased extracellular matrix (ECM) accumulation or production, and improved lung function. |
| FILED | Tuesday, October 25, 2022 |
| APPL NO | 17/972963 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/496 (20130101) A61K 31/519 (20130101) Original (OR) Class A61K 31/4418 (20130101) A61K 39/3955 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230128071 | Bourque et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | LOCKHEED MARTIN CORPORATION (Bethesda, Maryland) |
| ASSIGNEE(S) | LOCKHEED MARTIN CORPORATION (Bethesda, Maryland) |
| INVENTOR(S) | Richard T. Bourque (Oxford, Connecticut); Erik M. Byrne (Stratford, Connecticut) |
| ABSTRACT | A bushing assembly for a structure having a first aperture is provided. The bushing assembly includes a first component configured to be received by the first aperture and having a second aperture. A maximum width of the first component defines an outer diameter. The bushing assembly further includes a second component positioned outside of the first aperture and coupled to the first component, the second component having a third aperture extending through the second component. The third aperture is dimensioned so as to be equivalent to the outer diameter of the first component, and the first component and the second component are formed as discrete components of the bushing assembly. |
| FILED | Friday, October 22, 2021 |
| APPL NO | 17/507958 |
| CURRENT CPC | Shafts; Flexible Shafts; Elements or Crankshaft Mechanisms; Rotary Bodies Other Than Gearing Elements; Bearings F16C 17/02 (20130101) F16C 43/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230128143 | MOUW et al. |
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| FUNDED BY |
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| APPLICANT(S) | Kent William MOUW (Newton, Massachusetts); Judit BORCSOK (2100 Copenhagen, Denmark); Miklos DIOSSY (2100 Copenhagen, Denmark); THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts); DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts); DANISH CANCER SOCIETY (Copenhagen, Massachusetts) |
| INVENTOR(S) | Kent William MOUW (Newton, Massachusetts); Judit BORCSOK (Copenhagen, Denmark); Zsofia SZTUPINSZKI (Copenhagen, Denmark); Miklos DIOSSY (Copenhagen, Denmark); Zoltan SZALLASI (Boston, Massachusetts) |
| ABSTRACT | Provided herein are methods related to methods of predicting sensitivity to NER-targeting agents for the treatment of cancer. In one aspect, provided herein is a method for treating cancer in a subject) of at least 0.70 and the anti-cancer treatment comprises an alkylating chemotherapeutic agent. |
| FILED | Thursday, March 25, 2021 |
| APPL NO | 17/914052 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/122 (20130101) A61K 33/243 (20190101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230128159 | Luz et al. |
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| FUNDED BY |
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| APPLICANT(S) | General Electric Compnay (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James John Luz (Tewksbury, Massachusetts); Robert Burton Brown (Medford, Massachusetts); Thomas Bradley Kenney (Ashby, Massachusetts); Thomas Charles McCarthy (Boston, Massachusetts); Firas Younes (Randolph, Massachusetts) |
| ABSTRACT | A system for lubricating components of a gas turbine engine includes a supply pump to pump lubricant from a reservoir through a supply conduit to lubricated component. An outer body deicing circuit is fluidly coupled in series with the supply conduit. Moreover, a scavenge conduit extends from the lubricated component to the reservoir and a scavenge pump pumps the lubricant from the lubricated component through the scavenge conduit. In addition, a valve is fluidly coupled in series with the supply conduit and the scavenge conduit and a bypass conduit extends from the valve to a location on the supply conduit downstream of the deicing circuit. When the lubricant is supplied to the valve, the valve directs the lubricant flowing through the scavenge conduit into the reservoir. When the supply of lubricant to the valve is halted, the valve directs the lubricant flowing through the scavenge conduit into the bypass conduit. |
| FILED | Wednesday, July 20, 2022 |
| APPL NO | 17/813761 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 25/20 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/06 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2240/35 (20130101) F05D 2260/98 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230128344 | ZHANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | University of Southern California (Los Angeles, California) |
| INVENTOR(S) | Yong ZHANG (Los Angeles, California); Zhefu DAI (Los Angeles, California); Xiao-Nan ZHANG (Los Angeles, California) |
| ABSTRACT | Antibody-drug conjugates, compositions thereof, and methods use. The antibody-drug conjugates include a fusion protein comprising an antibody covalently linked to an ADP-ribosyl cyclase protein via a peptide linker moiety at one or more of a C-terminus or N-terminus of a heavy or light chain of the antibody, a NAD or NMN analogue, and a payload such that the NAD or NMN analogue is conjugated to both the payload and the ADP-ribosyl cyclase protein. |
| FILED | Monday, May 10, 2021 |
| APPL NO | 17/996313 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6807 (20170801) A61K 47/6815 (20170801) Original (OR) Class A61K 47/6851 (20170801) A61K 47/6889 (20170801) A61K 2039/505 (20130101) Peptides C07K 16/2851 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/2497 (20130101) Enzymes C12Y 302/02006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230129487 | Kolluri et al. |
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| FUNDED BY |
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| APPLICANT(S) | Oregon State University (Corvallis, Oregon) |
| ASSIGNEE(S) | Oregon State University (Corvallis, Oregon) |
| INVENTOR(S) | Siva K. Kolluri (Corvallis, Oregon); Prasad R. Kopparapu (Houston, Texas); Martin Pearce (Independence, Oregon) |
| ABSTRACT | Methods for inducing growth inhibition or apoptosis of Bcl-2-expressing cells and treatments of Bcl-2 expressing cancers are provided. Additionally, assays for agents that can induce apoptosis of Bcl-2 expressing cells are disclosed. |
| FILED | Friday, August 19, 2022 |
| APPL NO | 17/821146 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/167 (20130101) A61K 31/341 (20130101) Original (OR) Class A61K 38/16 (20130101) A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230129562 | TRAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland); The Regents of the University of Colorado, a body corporate (Denver, Colorado); Government of the United States of America as Represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Minh C. TRAN (College Park, Maryland); Abhinav DESHPANDE (College Park, Maryland); Andrew Y. GUO (College Park, Maryland); Andrew LUCAS (Boulder, Colorado); Alexey GORSHKOV (Potomac, Maryland) |
| ABSTRACT | A system for quantum state transfer and entanglement generation includes a quantum system including a plurality of qubits, a processor, and a memory. The memory includes instructions stored thereon, which, when executed by the processor, cause the quantum system to: access a signal of the quantum system; encode unknown coefficients in one qubit of the plurality of qubits; initialize each of the remaining qubits of the plurality of qubits in state |0 |
| FILED | Tuesday, October 04, 2022 |
| APPL NO | 17/959901 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/20 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230129777 | Hening et al. |
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| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexandru Hening (San Diego, California); Maria Dinescu (Bucharest, Romania); Wayne C. McGinnis (San Diego, California); Ryan P. Lu (San Diego, California) |
| ABSTRACT | An apparatus for laser deposition with a reactive gas includes a source, a target, and a substrate. The source emits a plasma jet of the reactive gas. The target generates a plasma plume of a deposition material when a laser beam ablates the target. The substrate collects a film resulting from a chemical reaction between the deposition material from the plasma plume and the reactive gas from the plasma jet. Correspondingly, a method for laser deposition with a reactive gas includes steps of emitting a plasma jet of the reactive gas, ablating a target with a laser beam, and collecting a film on a substrate. The plasma jet emits from an orifice of a source. Ablating the target generates a plasma plume of a deposition material. The film results from a chemical reaction between the deposition material from the plasma plume and the reactive gas from the plasma jet. |
| FILED | Thursday, October 21, 2021 |
| APPL NO | 17/507675 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/0036 (20130101) Original (OR) Class C23C 14/52 (20130101) C23C 14/541 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230129962 | Anderson et al. |
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| FUNDED BY |
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| APPLICANT(S) | Raytheon Technologies Corporation (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Corey D. Anderson (East Hartford, Connecticut); Edward Boucher (Watertown, Connecticut); Rebecca R. Dunnigan (Sturbridge, Massachusetts); Nicholas Broulidakis (Vernon, Connecticut); Matthew Murakami (West Hartford, Connecticut); Daniel R. Brandt (Easthampton, Connecticut); Konrad Kuc (West Hartford, Connecticut); Victoria M. Imlach (Marlborough, Connecticut); Sushruth G. Kamath (Manchester, Connecticut); Manuel A. Casares Rivas (East Hartford, Connecticut); Eric G. Leamon (Manchester, Connecticut); Adam Castles (Norwood, Massachusetts); Edmond Cheung (East Hartford, Connecticut); Kyra A. Thole-Wilson (West Hartford, Connecticut); Javier Nebero Johnson (East Hartford, Connecticut) |
| ABSTRACT | A gas turbine engine including a core having a compressor section fluidly connected to a combustor via a primary flowpath and a turbine section connected to the combustor via the core flow path. An assembly is disposed within the gas turbine engine and includes a first part connected to a second part via a radial stack joint. The first part includes a radially inward facing surface contacting a corresponding radially outward facing surface of the second part. A fastener protrudes through the first part and the second part and is configured to maintain the relative positions of the first part and the second part. A channel is disposed on at least one of the radially inward facing surfaces and is positioned between the fastener and a circumferential edge of the first part. The channel is connected to at least one cooling air source. |
| FILED | Monday, October 17, 2022 |
| APPL NO | 17/967315 |
| CURRENT CPC | Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/12 (20130101) F02C 7/18 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2230/60 (20130101) F05D 2260/232 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230130671 | Tisdale et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William A. Tisdale (Belmont, Massachusetts); Watcharaphol Paritmongkol (Boston, Massachusetts); Tomoaki Sakurada (Cambridge, Massachusetts) |
| ABSTRACT | A metal-organic chalcogenolate (MOC) includes silver phenylselenolate functionalized with at least one functional group. The functional group may be methyl (CH3), dimethylamine (N(CH3)2), thiomethyl (SCH3), fluoro (F) trifluoromethyl (CF3), cyanide (CN), carboxy (COOH), nitrito (NO2), or alkoxy (OCxHy). The MOC can be in the form of a single crystal consisting essentially of a nanocluster (0D), a nanotube (1D), or a single monolayer (2D). |
| FILED | Monday, October 25, 2021 |
| APPL NO | 17/509675 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 1/10 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0091 (20130101) H01L 51/4206 (20130101) H01L 51/5016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230130711 | Schmitt et al. |
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| FUNDED BY |
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| APPLICANT(S) | Spark Thermionics, Inc. (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Felix Schmitt (Berkeley, California); Jared William Schwede (Berkeley, California); Adam Lorimer (Berkeley, California) |
| ABSTRACT | A system for thermionic energy generation, preferably including one or more thermionic energy converters, and optionally including one or more power inputs, airflow modules, and/or electrical loads. A thermionic energy converter, preferably including an emitter module, a collector module, and/or a seal, and optionally including a spacer. The thermionic energy converter preferably defines a chamber and/or a heating cavity. A method for thermionic energy generation, preferably including receiving power, emitting electrons, and/or receiving the emitted electrons, and optionally including convectively transferring heat. |
| FILED | Friday, July 15, 2022 |
| APPL NO | 17/866381 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 45/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230130863 | Kuzdeba et al. |
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| FUNDED BY |
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| APPLICANT(S) | BAE SYSTEMS Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott A. Kuzdeba (Hollis, New Hampshire); Joseph M. Carmack (Milford, New Hampshire); James M. Stankowicz, JR. (Boston, Massachusetts) |
| ABSTRACT | A Deep-Learning (DL) system for representation and construction or reconstruction of signals includes an encoder stage; an encoding; an optional modification stage; a decoder stage, and a (re)construction stage. The encoder stage includes layers of dilated convolutions, and the encoder maps from an input representation into a latent embedded representation. It learns a set of features that encode the input signals. The encoding stage comprises latent space; the decoder stage maps from latent features back to an output of the same size as the input signals, whereby the output has the same dimensionality and representation as the input signals. Modification to the signal can be conducted within the latent representation to alter the (re)construction for specific tasks, such as increasing a device's RF fingerprint. |
| FILED | Friday, June 25, 2021 |
| APPL NO | 17/358153 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/063 (20130101) G06N 3/0464 (20230101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230131058 | Chabanov et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrey Chabanov (Austin, Texas); Carl Pfeiffer (Austin, Texas); Igor Anisimov (Austin, Texas); Ilya Vitebskiy (Austin, Texas) |
| ABSTRACT | The present disclosure relates to magnetization-free Faraday rotator systems, apparatuses, and related methods. One such system comprises a Faraday rotator device comprising a magneto-optical composite material having first and second magnetic component materials in a periodic or uniform pattern in an X-Y plane, wherein the first and second magnetic component materials are magnetized along a Z-axis in opposite directions and the Faraday rotator device produces nonzero magnetic Faraday rotation for the electromagnetic wave propagating in a Z-axis direction in the absence of an external bias magnetic field. |
| FILED | Monday, October 24, 2022 |
| APPL NO | 17/971949 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/093 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230131116 | Chandrahalim et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hengky Chandrahalim (Beavercreek, Ohio); Kyle T. Bodily (Xenia, Ohio) |
| ABSTRACT | The present invention relates to evanescently coupling whispering gallery mode optical resonators having a liquid coupling as well as methods of making and using same. The aforementioned evanescently coupling whispering gallery mode optical resonators having a liquid couplings provide increased tunability and sensing selectivity over current same. The aforementioned. Applicants' method of making evanescent-wave coupled optical resonators can be achieved while having coupling gap dimensions that can be fabricated using standard photolithography. Thus economic, rapid, and mass production of coupled WGM resonators-based lasers, sensors, and signal processors for a broad range of applications can be realized. |
| FILED | Thursday, October 21, 2021 |
| APPL NO | 17/506854 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/29341 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230131140 | Yadav et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of South Florida (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hariom Yadav (Tampa, Florida); Shalinie Jain (Tampa, Florida); Sidharth Mishra (Tampa, Florida) |
| ABSTRACT | The present disclosure provides for a method of treating increased gut permeability, including administering a therapeutically effective amount of a human-derived probiotic to a patient in need thereof. Further provided herein is a method of increasing a patient's metabolism of ethanolamine, including administering a therapeutically effective amount of human derived probiotics to the patient in need thereof. Also provided herein is a pharmaceutical composition, including a first strain of Lactobacillus and a second probiotic strain. The present disclosure also provides for a pharmaceutical composition, including Lactobacillus and an antidiabetic drug. Additionally, provided herein is a pharmaceutical composition, including Lactobacillus and a weight management drug. |
| FILED | Wednesday, October 26, 2022 |
| APPL NO | 17/973909 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/747 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230131501 | XU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Kansas (Lawrence, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Liang XU (Lawrence, Kansas); Xiaoqing WU (Lawrence, Kansas); Lan LAN (Lawrence, Kansas); Jeff Aube (Chapel Hill, Kansas) |
| ABSTRACT | The present technology is directed to methods of treatment utilizing inhibitors of HuR interaction with RNA, where the inhibitors are of Formula I where R1 is; and X1 is OH, NH—OH, or 0-(C1-C8 unsubstituted alkyl). |
| FILED | Monday, March 22, 2021 |
| APPL NO | 17/914287 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/337 (20130101) A61K 31/381 (20130101) Original (OR) Class A61K 31/704 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/18 (20180101) A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230131584 | Bayer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mustafa Mert Bayer (Irvine, California); Ozdal Boyraz (Irvine, California) |
| ABSTRACT | Various examples for multi-tone continuous wave detection and ranging are disclosed herein. In some embodiments, an initial signal is generated using initial radio frequency (RF) tones, and is emitted as a multi-tone continuous wave signal. The initial signal is reflected from a target and received as a reflected signal. Resultant RF tones, including a frequency, a phase and a power, are determined from the reflected signal in a frequency domain. A frequency-domain sinusoidal wave is fitted to the resultant RF tones in the frequency domain, and a distance to the target is determined using a modulation of the frequency-domain sinusoidal wave. A phase processing algorithm is applied to generate the target distance and speed by triangulating the range information encoded in the backscattered RF tones. |
| FILED | Friday, September 03, 2021 |
| APPL NO | 17/467012 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 13/584 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230131957 | Lowenberg et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Naval Information Warfare Center, Pacific (San Diego, California) |
| ASSIGNEE(S) | United States of America as Represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Lance V. Lowenberg (San Diego, California); Michael Tall (San Diego, California); Michael Ouimet (San Diego, California); Anthony D. Jones (San Diego, California) |
| ABSTRACT | The present invention relates to a system that can to capture, retain, and release a small UAV/drone. Exemplary embodiments include a plurality of capture mechanisms each include a capture arm coupled to an actuator. The capture mechanism can include two pivot points, one of which can move along a track or groove, to allow the capture arm to extend and retract while maintaining a small combined circumference during UAV landing while still being able to extend to engage with a retention ring on the UAV. |
| FILED | Thursday, October 21, 2021 |
| APPL NO | 17/507576 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 39/024 (20130101) B64C 2201/027 (20130101) B64C 2201/042 (20130101) B64C 2201/128 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 1/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230131958 | Deravi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Leila Deravi (Cambridge, Massachusetts); Camille A. Martin (Westbury, New York); Amrita Kumar (Cambridge, Massachusetts) |
| ABSTRACT | Cosmetic and dermatological compositions, including color changing compositions, are provided which typically include a plurality of synthetic particles having a size in the micrometer or nanometer range. Each synthetic particle typically includes one or more aggregates of a pigment selected from phenoxazone, phenoxazine, and a derivate or precursor thereof, and a stabilizing material which has a refractive index larger than 1.45; the aggregates having a size larger than about 100 nm and the composition being biodegradable and biocompatible. |
| FILED | Tuesday, August 16, 2022 |
| APPL NO | 17/819981 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 8/25 (20130101) A61K 8/26 (20130101) A61K 8/29 (20130101) Original (OR) Class A61K 8/49 (20130101) A61K 8/73 (20130101) A61K 8/85 (20130101) A61K 8/86 (20130101) A61K 8/0245 (20130101) A61K 8/0275 (20130101) A61K 8/0283 (20130101) A61K 8/411 (20130101) A61K 8/8152 (20130101) A61K 2800/45 (20130101) A61K 2800/52 (20130101) A61K 2800/412 (20130101) A61K 2800/438 (20130101) A61K 2800/651 (20130101) A61K 2800/654 (20130101) Specific Use of Cosmetics or Similar Toilet Preparations A61Q 17/04 (20130101) A61Q 19/08 (20130101) Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 19/00 (20130101) C09B 61/00 (20130101) C09B 67/0097 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230131980 | Tracey et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH (Manhasset, New York) |
| ASSIGNEE(S) | THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH (Manhasset, New York) |
| INVENTOR(S) | Kevin J. Tracey (Old Greenwich, Connecticut); Sangeeta S. Chavan (Syosset, New York) |
| ABSTRACT | Methods are disclosed for treating a subject having a disease or disorder comprising stimulating a nerve of the subject with a corrective stimulus pattern derived from a disease-specific, condition-specific, endogenous mediator-specific or pharmacologic agent-specific neurogram in an amount and manner effective to treat the disease or disorder. |
| FILED | Monday, December 19, 2022 |
| APPL NO | 18/083629 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/36002 (20170801) A61N 1/36007 (20130101) A61N 1/36053 (20130101) A61N 1/36071 (20130101) A61N 1/36135 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230132026 | Ma et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Florida State University Research Foundation, Inc. (Tallahassee, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Biwu Ma (Tallahassee, Florida); Liang-Jin Xu (Tallahassee, Florida); Qingquan He (Tallahassee, Florida) |
| ABSTRACT | Methods of scintillation, scintillation devices, and metal halide hybrids that may be used as X-ray scintillators. The metal halide hybrids may include organic metal halide hybrids, inorganic metal halide hybrids, or organic-inorganic metal halide hybrids. The metal halide hybrids may have a 0D structure. The metal halide hybrids may be in the form of one or more discrete crystals. |
| FILED | Friday, March 12, 2021 |
| APPL NO | 17/909611 |
| CURRENT CPC | Measurement of Nuclear or X-radiation G01T 1/2002 (20130101) G01T 1/2018 (20130101) G01T 1/2023 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230132224 | Demkov et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander A. Demkov (Austin, Texas); John Elliott Ortmann, Jr. (Austin, Texas); Agham Posadas (Round Rock, Texas) |
| ABSTRACT | Electro-optic modulators and related devices and methods. The method includes forming a silicon dioxide layer on a silicon substrate. The method includes forming a doped silicon layer in or on the silicon dioxide layer. The method includes forming alternating layers of functional transition metal oxides (TMOs) on the doped silicon layer. Design parameters can be optimized to create realizable devices that minimize the energy consumption of, for example, a SrTiO3/LaAlO3 electro-optic modulator while maximizing electro-optic performance (e.g., modulation energies on the order of tens of pJ/bit). |
| FILED | Monday, March 08, 2021 |
| APPL NO | 17/908599 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 33/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20230125131 | Gao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Liang Gao (Santa Clara, California); Xiaohua Feng (Los Angeles, California) |
| ABSTRACT | Systems and methods are provided for ultrafast light field tomography (LIFT), a transient imaging strategy that offers a temporal sequence of over 1000 and enables highly efficient light field acquisition, allowing snapshot acquisition of the complete two, three or four-dimensional space and time. The apparatus transforms targets in object space into parallel lines in the image plane with a cylindrical lens. Beam projections are optionally directed through a Dove prism and an array of cylindrical lenslets to an imaging device such as a SPAD camera, streak camera and CCD camera. By using an array of cylindrical lenslets oriented at distinct angles, enough projections are obtained simultaneously to recover the image with a single snapshot. The time-resolved system and methods were adapted to LIDAR, hyperspectral, non-line-of-sight, and three-dimensional transient imaging. |
| FILED | Wednesday, October 12, 2022 |
| APPL NO | 18/046016 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 30/27 (20200101) Original (OR) Class Pictorial Communication, e.g Television H04N 13/232 (20180501) H04N 23/957 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230125793 | Lou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | William Marsh Rice University (Houston, Texas) |
| ASSIGNEE(S) | WILLIAM MARSH RICE UNIVERSITY (Houston, Texas) |
| INVENTOR(S) | Jun Lou (Houston, Texas); Qilin Li (Houston, Texas); Weipeng Wang (Houston, Texas); Kuichang Zuo (Houston, Texas); Shuai Jia (Houston, Texas); Weibing Chen (Houston, Texas) |
| ABSTRACT | Methods of making hexagonal boron nitride coatings upon stainless steel and other ferrous metal/alloy materials, compositions thereof, and methods of using same, such as in electrothermal membrane distillation systems using hexagonal boron nitride coated metal mesh. |
| FILED | Wednesday, October 26, 2022 |
| APPL NO | 17/974297 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/0227 (20130101) C23C 16/342 (20130101) Original (OR) Class C23C 16/463 (20130101) C23C 16/4481 (20130101) C23C 16/45557 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230126460 | Rickli et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wayne State University (Detroit, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeremy L. Rickli (Royal Oak, Michigan); Murat Yildirim (Macomb, Michigan); Mohamed Kilani (Pontiac, Michigan); Edward Kim (West Bloomfield, Michigan); Jeremy Epple (Macomb, Michigan) |
| ABSTRACT | A system for predicting machine failure may include a controller for controlling a machine, a plurality of sensors, a plugin device, a first computing device, a second computing device, and/or a third computing device. The sensors and/or the plugin device may be communicatively coupled to the controller. The first computing device may be communicatively coupled to the plugin device. The plugin device may transmit data associated with the machine to the first computing device. The first computing device may execute at least one low fidelity model to determine an interesting event associated with the machine. The second computing device may be communicatively coupled to the first computing device. The first computing device may transmit data associated with the interesting event to the second computing device. The second computing device may execute at least one high fidelity model to determine a machine failure prediction. |
| FILED | Friday, October 21, 2022 |
| APPL NO | 17/970758 |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 23/0272 (20130101) G05B 23/0283 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230126514 | Bucci et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vanni Bucci (Concord, Massachusetts); Benedikt M. Mortzfeld (Newton, Massachusetts); Jacob Palmer (Oxford, United Kingdom) |
| ABSTRACT | This disclosure relates to genetically engineered microorganisms for overexpressing microcin compositions, e.g., MccH47 compositions and MccI47 compositions, which are post-translationally modified with a covalent linkage at the C-terminus to a siderophore, such as mono-glycosylated cyclic enterobactin (MGE), to form microcin-MGE compositions, e.g., MccH47-MGE and MccI47-MGE compositions, the purified compositions themselves, methods of making the purified compositions, and methods of using the purified compositions to treat or reduce the risk of bacterial infections or dysbiosis. |
| FILED | Tuesday, February 23, 2021 |
| APPL NO | 17/801671 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 14/245 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 15/70 (20130101) C12N 2510/00 (20130101) C12N 2800/101 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230126566 | ZHU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MARYLAND, BALTIMORE COUNTY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Weidong ZHU (Ellicott City, Maryland); Linfeng LYU (Halethorpe, Maryland) |
| ABSTRACT | A one-dimensional (1D) and two-dimensional (2D) scan scheme for a tracking continuously scanning laser Doppler vibrometer (CSLDV) system to scan the whole surface of a rotating structure excited by a random force. A tracking CSLDV system tracks a rotating structure and sweep its laser spot on its surface. The measured response of the structure using the scan scheme of the tracking CSLDV system is considered as the response of the whole surface of the structure subject to random excitation. The measured response can be processed by operational modal analysis (OMA) methods (e.g., an improved lifting method, an improved demodulation method, an improved 2D demodulation method). Damped natural frequencies of the rotating structure are estimated from the fast Fourier transform of the measured response. Undamped full-field mode shapes are estimated by multiplying the measured response using sinusoids whose frequencies are estimated damped natural frequencies. |
| FILED | Friday, October 21, 2022 |
| APPL NO | 18/048567 |
| CURRENT CPC | Wind Motors F03D 17/00 (20160501) Measurement of Mechanical Vibrations or Ultrasonic, Sonic or Infrasonic Waves G01H 9/00 (20130101) Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 7/025 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230126916 | Lupton et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Myolex Inc (Brookline, Massachusetts) |
| ASSIGNEE(S) | Myolex Inc. (Brookline, Massachusetts) |
| INVENTOR(S) | Elmer C Lupton (Charlestown, Massachusetts); Haydn Taylor (Windham, New Hampshire); Ken Li (Wellesley, Massachusetts); Michael Rinehart (San Jose, California); Jose Bohorquez (Brookline, Massachusetts) |
| ABSTRACT | Embodiments of devices and methods for evaluating tissue are disclosed. In one embodiment, a method for measuring a characteristic of a tissue may include passing a current through the tissue, measuring a signal corresponding to the voltage resulting from passing the current through the tissue, analyzing current passed through the tissue and resulting voltage to determine the electrical characteristics of the tissue; and analyzing the electrical characteristics of the tissue to determine a status of the tissue. Methods for achieving relatively constant sensor application pressure are disclosed. |
| FILED | Sunday, February 13, 2022 |
| APPL NO | 17/670479 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/053 (20130101) Original (OR) Class A61B 5/486 (20130101) A61B 5/0537 (20130101) A61B 5/684 (20130101) A61B 5/742 (20130101) A61B 5/4519 (20130101) A61B 5/6843 (20130101) A61B 5/7221 (20130101) A61B 5/7225 (20130101) A61B 5/7278 (20130101) A61B 5/7405 (20130101) A61B 5/7475 (20130101) A61B 2017/0023 (20130101) A61B 2560/0443 (20130101) A61B 2560/0468 (20130101) A61B 2562/04 (20130101) A61B 2562/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230127106 | Aukes et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Daniel Aukes (Gilbert, Arizona); Mohammad Sharifzadeh (San Diego, California); Yuhao Jiang (Tempe, Arizona); Nicholas Gravish (San Diego, California); Mingsong Jiang (Anshan, China PRC) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Aukes (Gilbert, Arizona); Mohammad Sharifzadeh (San Diego, California); Yuhao Jiang (Tempe, Arizona); Nicholas Gravish (San Diego, California); Mingsong Jiang (Anshan, China PRC) |
| ABSTRACT | A device includes a tube and a sleeve configured to at least partially encircle a portion the tube along its length. The tube is flexible and airtight and defines a longitudinal axis along a center of the tube, and is configured to bend along the longitudinal axis upon at least partial evacuation of the tube to form a joint. The joint defines a joint angle relative to the longitudinal axis, thereby approximating a revolute joint with torsional stiffness. Actuating a joint includes partially evacuating a flexible tube defining a longitudinal axis, thereby forming a bend in the tube at an angle with respect to the longitudinal axis at a perimeter of a rigid sleeve at least partially encircling the tube, and restoring a neutral pressure to the tube, thereby removing the bend in the tube. |
| FILED | Friday, October 21, 2022 |
| APPL NO | 17/971062 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/06 (20130101) B25J 9/142 (20130101) B25J 17/0241 (20130101) B25J 18/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230127524 | Cui et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Honggang Cui (Lutherville, Maryland); Caleb French Anderson (Baltimore, Maryland) |
| ABSTRACT | The present invention provides supramolecular filament and/or sphere compositions and their use as inhalable drug carriers within aerosols. The invention provides insights into peptide designs and supramolecular stability and its crucial role in the interfacial stability and aerosolization properties of the supramolecular filament and/or sphere compositions. The compositions and their properties show that molecular enrichment at the air-liquid interface during nebulization is the primary factor to deplete the monomeric peptide amphiphiles in solution, accounting for the observed morphological disruption/transitions. Importantly, encapsulation of drugs and dyes within the inventive filament and/or sphere compositions notably stabilize their supramolecular structure during nebulization, and the loaded filaments exhibit a linear release profile from a nebulizer device. The compositions disclosed herein can be used as an effective platform for the inhalation-based treatment of many lung and sinusoidal diseases. |
| FILED | Wednesday, October 21, 2020 |
| APPL NO | 17/770826 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/12 (20130101) A61K 9/0092 (20130101) A61K 47/42 (20130101) A61K 47/65 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230127548 | Yeo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eugene Yeo (La Jolla, California); Eric Van Nostrand (La Jolla, California); Nathan Gianneschi (La Jolla, California); David A. Nelles (La Jolla, California); Sarah Barnhill (La Jolla, California); Anthony Rush (La Jolla, California) |
| ABSTRACT | Provided herein are methods of identifying a cell uptake modulator of a molecule that include (a) contacting a plurality of cells of a cell-containing biological sample with a plurality of gene-editing agents, wherein a gene-editing agent from the plurality of gene-editing agents recognizes and alters a target gene of at least one cell of the plurality of cells; (b) contacting the plurality of cells with a plurality of molecules, wherein at least one molecule of the plurality of molecules is transported into at least one cell of the plurality of cells; and (c) detecting a presence of the at least one molecule in the plurality of cells, thereby identifying the cell uptake modulator of the molecule. |
| FILED | Wednesday, September 28, 2022 |
| APPL NO | 17/936216 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1079 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230127698 | Dave et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida); STEREOLOGY RESOURCE CENTER, INC. (Saint Petersburg, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Palak Pankajbhai Dave (Wesley Chapel, Florida); Dmitry Goldgof (Lutz, Florida); Lawrence O. Hall (Tampa, Florida); Peter R. Mouton (Gulfport, Florida) |
| ABSTRACT | Systems and methods for automated stereology using deep learning are disclosed. The systems include an update in the form of a semi-automatic approach for ground truth preparation in 3D stacks of microscopy images (disector stacks) for generating more training data. The systems also present an exemplary disector-based MIMO framework where all the planes of a 3D disector stack are analyzed as opposed to a single focus-stacked image (EDF image) per stack. The MIMO approach avoids the costly computations of 3D deep learning-based methods by using the 3D context of cells in disector stacks; and prevents stereological bias in the previous EDF-based method due to counting profiles rather than cells and under-counting overlap-ping/occluded cells. Taken together, these improvements support the view that AI-based automatic deep learning methods can accelerate the efficiency of unbiased stereology cell counts without a loss of accuracy or precision as compared to conventional manual stereology. |
| FILED | Friday, October 21, 2022 |
| APPL NO | 17/971295 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 20/00 (20190101) Image Data Processing or Generation, in General G06T 5/002 (20130101) G06T 5/20 (20130101) G06T 7/11 (20170101) G06T 7/0014 (20130101) Original (OR) Class G06T 7/97 (20170101) G06T 7/174 (20170101) G06T 17/205 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/20152 (20130101) Image or Video Recognition or Understanding G06V 20/695 (20220101) G06V 20/698 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230127791 | Rojas et al. et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Embry-Riddle Aeronautical University, Inc. (Daytona Beach, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eduardo Antonio Rojas et al. (Port Orange, Florida); Susan Davis Allen (New Smyrna Beach, Florida) |
| ABSTRACT | Additive manufacturing can include use of a laser-machining technique. Laser machining can be used to form cavities, trenches, or other features in an additively-manufactured structure. Spectroscopy can be performed to monitor a laser machining operation. For example, a laser-enhanced additive manufacturing process flow can include depositing a conductive layer on a surface of a dielectric layer, and conductively isolating a first region from a second region of the conductive layer using ablative optical energy, including applying ablative optical energy to the conductive layer, monitoring a spectrum of an ablative plume generated by applying the ablative optical energy, and controlling the ablative optical energy in response to a characteristic of the spectrum of the ablative plume. |
| FILED | Thursday, October 20, 2022 |
| APPL NO | 18/048349 |
| CURRENT CPC | Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/40 (20130101) Original (OR) Class B23K 26/705 (20151001) B23K 26/707 (20151001) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 30/00 (20141201) B33Y 40/20 (20200101) B33Y 50/02 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230127880 | Redden |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Blue River Technology Inc. (Sunnyvale, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lee Kamp Redden (Palo Alto, California) |
| ABSTRACT | Described are methods for identifying the in-field positions of plant features on a plant by plant basis. These positions are determined based on images captured as a vehicle (e.g., tractor, sprayer, etc.) including one or more cameras travels through the field along a row of crops. The in-field positions of the plant features are useful for a variety of purposes including, for example, generating three-dimensional data models of plants growing in the field, assessing plant growth and phenotypic features, determining what kinds of treatments to apply including both where to apply the treatments and how much, determining whether to remove weeds or other undesirable plants, and so on. |
| FILED | Thursday, December 15, 2022 |
| APPL NO | 18/082312 |
| CURRENT CPC | Electric Digital Data Processing G06F 18/2415 (20230101) Image Data Processing or Generation, in General G06T 7/593 (20170101) Image or Video Recognition or Understanding G06V 10/764 (20220101) G06V 20/38 (20220101) G06V 20/188 (20220101) Pictorial Communication, e.g Television H04N 13/128 (20180501) H04N 13/204 (20180501) H04N 13/239 (20180501) H04N 13/243 (20180501) Original (OR) Class H04N 13/271 (20180501) H04N 2013/0081 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230128742 | Walk et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California); Technische Universität Berlin (Berlin, Germany) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California); Technische Universität Berlin (Berlin, Germany) |
| INVENTOR(S) | Philipp Walk (Pasadena, California); Babak Hassibi (San Marino, California); Peter Jung (Berlin, Germany) |
| ABSTRACT | Systems and methods for transmitting data using various Modulation on Zeros schemes are described. In many embodiments, a communication system is utilized that includes a transmitter having a modulator that modulates a plurality of information bits to encode the bits in the zeros of the z-transform of a discrete-time baseband signal. In addition, the communication system includes a receiver having a decoder configured to decode a plurality of bits of information from the samples of a received signal by: determining a plurality of zeros of a z-transform of a received discrete-time baseband signal based upon samples from a received continuous-time signal, identifying zeros that encode the plurality of information bits, and outputting a plurality of decoded information bits based upon the identified zeros. |
| FILED | Thursday, June 02, 2022 |
| APPL NO | 17/805207 |
| CURRENT CPC | Multiplex Communication H04J 11/00 (20130101) H04J 2011/0096 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 25/0204 (20130101) H04L 27/2627 (20130101) Original (OR) Class H04L 27/2639 (20130101) H04L 27/2663 (20130101) H04L 27/26532 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230129378 | Tian et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Limei Tian (College Station, Texas); Gerard L. Coté (College Station, Texas); Ze Yin (College Station, Texas); Heng Guo (College Station, Texas) |
| ABSTRACT | Embodiments of the present disclosure pertain to a sensor that includes a transduction agent, a plurality of analyte binding agents immobilized on the transduction agent, and a coating agent that forms a coating around at least some of the analyte binding agents. Further embodiments of the present disclosure pertain to methods of detecting one or more analytes in a sample by associating the sample with a sensor of the present disclosure; detecting a signal from the sensor; and correlating the signal to the presence or absence of the one or more analytes in the sample. Additional embodiments of the present disclosure pertain to methods of making the sensors of the present disclosure by immobilizing a plurality of analyte binding agents on a transduction agent; and coating at least some of the analyte binding agents with a coating agent to form a sensor. |
| FILED | Wednesday, February 24, 2021 |
| APPL NO | 17/904873 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) B82Y 40/00 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/1675 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/54346 (20130101) G01N 33/56983 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230129434 | Takshi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arash Takshi (Tampa, Florida); Sabrina Marie Rosa-Ortiz (Tampa, Florida) |
| ABSTRACT | A hydrogen evolution assisted electroplating nozzle includes a nozzle tip configured to interface with a portion of a substructure. The nozzle also includes an inner coaxial tube connected to a reservoir containing an electrolyte and an anode, the inner coaxial tube configured to dispense the electrolyte through the nozzle tip onto the portion of the substructure. The nozzle also includes an outer coaxial tube encompassing the inner coaxial tube, the outer coaxial tube configured to extract the electrolyte from the portion of the substructure. The nozzle also includes at least one contact pin configured to make electrical contact with a conductive track on the substrate. |
| FILED | Thursday, December 22, 2022 |
| APPL NO | 18/145732 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/20 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 1/003 (20130101) C25D 3/38 (20130101) C25D 5/02 (20130101) C25D 5/003 (20130101) C25D 5/04 (20130101) C25D 5/08 (20130101) Original (OR) Class C25D 5/026 (20130101) C25D 5/54 (20130101) C25D 7/00 (20130101) C25D 7/04 (20130101) C25D 17/005 (20130101) C25D 17/06 (20130101) C25D 17/10 (20130101) C25D 17/12 (20130101) C25D 21/12 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 3/241 (20130101) H05K 3/246 (20130101) H05K 3/328 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230129475 | RAJARAMAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Swaminathan RAJARAMAN (Winter Park, Florida); Charles M. DIDIER (Dunedin, Florida); Julia FREITAS ORRICO (Orlando, Florida) |
| ABSTRACT | A three-dimensional (3D) microelectrode array device for in vitro electrophysiological applications includes a substrate and micro vias extending from the bottom face to the top face of the substrate. A microneedle at each micro via extends from the bottom face upward beyond the top face and forms a hypodermic microneedle array on the top face. Metallic traces on the bottom face interconnect the hypodermic microneedles to form the 3D microelectrode array. A microheater is positioned on the bottom face of the substrate. Microfluidic ports may be formed at the substrate. Interdigitated electrodes may be formed at the substrate. |
| FILED | Thursday, October 13, 2022 |
| APPL NO | 18/046161 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) Original (OR) Class C12M 23/16 (20130101) C12M 25/02 (20130101) C12M 41/12 (20130101) C12M 41/46 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230129562 | TRAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland); The Regents of the University of Colorado, a body corporate (Denver, Colorado); Government of the United States of America as Represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Minh C. TRAN (College Park, Maryland); Abhinav DESHPANDE (College Park, Maryland); Andrew Y. GUO (College Park, Maryland); Andrew LUCAS (Boulder, Colorado); Alexey GORSHKOV (Potomac, Maryland) |
| ABSTRACT | A system for quantum state transfer and entanglement generation includes a quantum system including a plurality of qubits, a processor, and a memory. The memory includes instructions stored thereon, which, when executed by the processor, cause the quantum system to: access a signal of the quantum system; encode unknown coefficients in one qubit of the plurality of qubits; initialize each of the remaining qubits of the plurality of qubits in state |0 |
| FILED | Tuesday, October 04, 2022 |
| APPL NO | 17/959901 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/20 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230130680 | Baptist et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| ASSIGNEE(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| INVENTOR(S) | Joshua R. Baptist (Louisville, Kentucky); Mohammad Nasser Saadatzi (Louisville, Kentucky); Zhong Yang (Louisville, Kentucky); Ruoshi Zhang (Louisville, Kentucky); Dan O. Popa (Louisville, Kentucky) |
| ABSTRACT | A robot skin apparatus includes polymer membranes encapsulating a pressure sensor. The sensor includes piezo-sensitive material in contact with a pair of electrodes in spaced relationship to form a circuit. The apparatus may include a flexible substrate, with the electrodes thereon. The piezo-sensitive material may be piezoresistive film. The electrodes may be symmetrically patterned on the substrate to form a substantially circular peripheral boundary. The apparatus may include pressure sensors on opposite sides of a plane for temperature compensation, a plurality of pressure sensors arrayed on the substrate, and a data acquisition system. A method of fabricating the apparatus includes a wet lithography process for patterning the piezoresistive film. A system includes a pair of gripper fingers, an actuator connected to the fingers, a robot skin apparatus positioned on one of the fingers, and an electronic unit for receiving data from the robot skin and controlling the fingers. |
| FILED | Thursday, December 22, 2022 |
| APPL NO | 18/086877 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 13/084 (20130101) Original (OR) Class B25J 15/024 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230131300 | LI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honda Motor Co., Ltd. (Tokyo, Japan); The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xufan LI (Fremont, California); Avetik HARUTYUNYAN (Santa Clara, California); Xiangye LIU (Xi'an, China PRC); Baiching LI (New York, New York); James Curtis HONE (New York, New York); Daniel V. ESPOSITO (New York, New York) |
| ABSTRACT | Aspects of the present disclosure generally relate to catalyst compositions including metal chalcogenides, processes for producing such catalyst compositions, processes for enhancing catalytic active sites in such catalyst compositions, and uses of such catalyst compositions in, e.g., processes for producing conversion products. In an aspect, a process for forming a catalyst composition is provided. The process includes introducing an electrolyte material and an amphiphile material to a metal chalcogenide to form the catalyst composition. In another aspect, a catalyst composition is provided. The catalyst composition includes a metal chalcogenide, an electrolyte material, and an amphiphile material. Devices for hydrogen evolution reaction are also provided. |
| FILED | Wednesday, December 21, 2022 |
| APPL NO | 18/086089 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 27/043 (20130101) B01J 27/051 (20130101) B01J 27/0573 (20130101) B01J 27/0576 (20130101) B01J 37/344 (20130101) Original (OR) Class Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/04 (20130101) C25B 11/075 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230131816 | Zheng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE UNIVERSITY OF CHICAGO (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Haitao Zheng (Chicago, Illinois); Ben Zhao (Chicago, Illinois); Pedro Lopes (Chicago, Illinois); Yuxin Chen (Chicago, Illinois); Huiying Li (Chicago, Illinois); Shan-Yuan Teng (Chicago, Illinois) |
| ABSTRACT | A microphone jammer includes a base and a signal generator mounted to the base. The signal generator is configured to generate an ultrasonic signal. The jammer also includes one or more transducers mounted to the base and configured to transmit the ultrasonic signal. The one or more transducers are mounted in a curved layout about the base. |
| FILED | Wednesday, March 31, 2021 |
| APPL NO | 17/915234 |
| CURRENT CPC | Secret Communication; Jamming of Communication H04K 3/42 (20130101) Original (OR) Class H04K 2203/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230132011 | Maschmann et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Curators of the University of Missouri (Columbia, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew R. Maschmann (Columbia, Missouri); Matthias J. Young (Columbia, Missouri) |
| ABSTRACT | A method of depositing a nanoscale-thin film onto a substrate is disclosed. The method generally comprises depositing a layer of a solid or gaseous state functionalizing molecule onto or adjacent to the first surface of the substrate and exposing the first surface to a source of ionizing radiation, thereby functionalizing the first surface of the substrate. Once the layer of functionalizing molecule is removed, a nanoscale-thin film is then deposited onto the functionalized first surface of the substrate. |
| FILED | Friday, December 23, 2022 |
| APPL NO | 18/146043 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/20 (20130101) C23C 16/0263 (20130101) Original (OR) Class C23C 16/403 (20130101) C23C 16/45527 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230132026 | Ma et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Florida State University Research Foundation, Inc. (Tallahassee, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Biwu Ma (Tallahassee, Florida); Liang-Jin Xu (Tallahassee, Florida); Qingquan He (Tallahassee, Florida) |
| ABSTRACT | Methods of scintillation, scintillation devices, and metal halide hybrids that may be used as X-ray scintillators. The metal halide hybrids may include organic metal halide hybrids, inorganic metal halide hybrids, or organic-inorganic metal halide hybrids. The metal halide hybrids may have a 0D structure. The metal halide hybrids may be in the form of one or more discrete crystals. |
| FILED | Friday, March 12, 2021 |
| APPL NO | 17/909611 |
| CURRENT CPC | Measurement of Nuclear or X-radiation G01T 1/2002 (20130101) G01T 1/2018 (20130101) G01T 1/2023 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230132034 | Barsoum et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Drexel University (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michel W. Barsoum (Moorestown, New Jersey); Di Zhao (Beijing, China PRC); Varun Natu (Philadelphia, Pennsylvania) |
| ABSTRACT | The present disclosure describes a crumpled form of Mxene materials, and methods of making and using these novel compositions. |
| FILED | Thursday, December 08, 2022 |
| APPL NO | 18/063093 |
| CURRENT CPC | Flotation; Differential Sedimentation B03D 3/06 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/921 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20230125242 | Sant et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gaurav Sant (Los Angeles, Massachusetts); Xin Chen (Los Angeles, California); Ross Alexander Arnold (Los Angeles, California); Dante Adam Simonetti (Los Angeles, California); Sara Vallejo Castano (Los Angeles, California); Dale Philip Prentice (Los Angeles, California); David Jassby (Los Angeles, California); Shengcun Ma (Los Angeles, California) |
| ABSTRACT | A method of preparing metal hydroxides from industrial wastes or alkaline rocks is provided. The method comprise subjecting a mixture comprising a solvent and a solid substrate to a stimulus in order to leach a metal cation from the solid substrate into the solvent, thereby forming a solution comprising the metal cation in the solvent; and contacting the solution of comprising the metal cation with a cathode, thereby electrolytically precipitating the metal hydroxide from the solution. The stimulus may be chemical, mechanical, or both. |
| FILED | Monday, October 24, 2022 |
| APPL NO | 17/972392 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/18 (20130101) Original (OR) Class C25B 11/034 (20210101) C25B 11/046 (20210101) C25B 15/083 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20230125924 — MULTI-FUNCTIONAL EQUIPMENT FOR DIRECT DECARBONIZATION WITH IMPROVED INDOOR AIR QUALITY
| US 20230125924 | Nawaz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kashif Nawaz (Oak Ridge, Tennessee); Brian A. Fricke (Oak Ridge, Tennessee); Xin Sun (Oak Ridge, Tennessee); Scott Sluder (Oak Ridge, Tennessee); Constantinos Tsouris (Oak Ridge, Tennessee); Michelle K. Kidder (Oak Ridge, Tennessee); Christopher J. Janke (Oak Ridge, Tennessee); Kai Li (Oak Ridge, Tennessee); Joshua A. Thompson (Oak Ridge, Tennessee) |
| ABSTRACT | A method of capturing carbon dioxide (CO2) present in air is provided. The method includes adding a carbon-dioxide-capturing device to a heating, ventilation, and air conditioning (HVAC) system of a building. The carbon-dioxide-capturing device is added to one or both of an air handler and air-distribution ductwork of the HVAC system. The method further includes circulating air including carbon dioxide through the carbon-dioxide-capturing device in the HVAC system. A direct decarbonization system for capturing carbon dioxide present in air is also provided. The system includes an HVAC unit, air-distribution ductwork connected to the HVAC unit, and a carbon-dioxide-capturing device disposed in one or both of the HVAC unit and the air-distribution ductwork. Carbon dioxide gas present in air passing through the HVAC unit or the air-distribution ductwork is removable from the air by the carbon-dioxide-capturing device. |
| FILED | Wednesday, October 26, 2022 |
| APPL NO | 17/974227 |
| CURRENT CPC | Separation B01D 53/1475 (20130101) Air-conditioning; Air-humidification; Ventilation; Use of Air Currents for Screening F24F 8/125 (20210101) Original (OR) Class F24F 8/175 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230126087 | Singal et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kalpesh Singal (Ballston Spa, New York); Fernando Javier D'Amato (Niskayuna, New York); Masoud Abbaszadeh (Clifton Park, New York) |
| ABSTRACT | Systems and methods are provided for the control of an industrial asset, such as a power generating asset. Accordingly, an interceptor module receives a state-change instruction from a state module that directs a change from a first state condition to a second state condition. The first and second state conditions direct modes of operation of at least one sub module of the controller of the industrial asset. The interceptor module then correlates the state-change instruction to a state-change classification. Based on the state-change classification, the interceptor module identifies an indication of a mode-switching attack. In response to the identification of the mode-switching attack, at least one mitigation response is implemented. |
| FILED | Monday, October 25, 2021 |
| APPL NO | 17/509159 |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/045 (20130101) Electric Digital Data Processing G06F 21/552 (20130101) G06F 21/554 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230126417 | Mane et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Anil U. Mane (Naperville, Illinois); Jeffrey W. Elam (Elmhurst, Illinois); Donghyeon Kang (Chicago, Illinois); Sara Kuraitis (Boise, Idaho); Elton Graugnard (Boise, Idaho) |
| ABSTRACT | A method of making thin films of sodium fluorides and their derivatives by atomic layer deposition (“ALD”). A sodium precursor is exposed to a substrate in an ALD reactor. The sodium precursor is purged, leaving the substrate with a sodium intermediate bound thereon. A fluorine precursor is exposed to the bound sodium intermediate in the ALD reactor. The fluorine precursor is purged and a sodium fluoride film is formed on the substrate. |
| FILED | Friday, October 22, 2021 |
| APPL NO | 17/508802 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/52 (20130101) C23C 16/4408 (20130101) C23C 16/45527 (20130101) C23C 16/45553 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230127207 | Abbott et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | TerraPower, LLc (Bellevue, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan Abbott (Woodinville, Washington); Darryl Appelgate (Woodinville, Washington); Haley Barsa (Issaquah, Washington); Michael T. Blatnik (Seattle, Washington); Karl Britsch (Mukilteo, Washington); Anselmo T. Cisneros, JR. (Seattle, Washington); Brian C. Kelleher (Edmonds, Washington); Samuel S. Goodrich (Richland, Washington); Ramesh Rajasekaran (Bellevue, Washington); Daniel J. Walter (North Bend, Washington); Kent E. Wardle (Renton, Washington); Matthew D. Wargon (Seattle, Washington) |
| ABSTRACT | A simple nuclear reactor in which most of the reflector material is outside of the reactor vessel is described. The reactor vessel is a cylinder that contains all of the fuel salt and a displacement component, which may be a reflector, in the upper section of the reactor vessel. Other than the displacement component, the reflector elements including a radial reflector and a bottom reflector are located outside the vessel. The salt flows around the outside surface of the displacement component through a downcomer heat exchange duct defined by the exterior of the displacement component and the interior surface of the reactor vessel. This design reduces the overall size of the reactor vessel for a given volume of salt relative to designs with internal radial or bottom reflectors. |
| FILED | Monday, October 10, 2022 |
| APPL NO | 18/045398 |
| CURRENT CPC | Nuclear Reactors G21C 3/54 (20130101) G21C 11/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230128213 | DONG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tao DONG (Lakewood, Colorado); Robert David ALLEN (Golden, Colorado); Lieve LAURENS (Golden, Colorado) |
| ABSTRACT | Described herein are compositions and methods for the conversion of chlorophyll-derived phytol into useful and economically viable surfactants. The provided compositions utilize the hydrophobic phytol structure and added functional groups to increase hydrophilicity at one end of the molecule. |
| FILED | Friday, October 21, 2022 |
| APPL NO | 17/970938 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 23/28 (20220101) C09K 23/32 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230128630 | Teeneti et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Chakridhar Reddy Teeneti (North Logan, Utah); Regan A. Zane (Hyde Park, Utah); Hongjie Wang (North Logan, Utah); Dorai Babu Yelaverthi (Raleigh, North Carolina) |
| ASSIGNEE(S) | Utah State University (Logan, Utah) |
| INVENTOR(S) | Chakridhar Reddy Teeneti (North Logan, Utah); Regan A. Zane (Hyde Park, Utah); Hongjie Wang (North Logan, Utah); Dorai Babu Yelaverthi (Raleigh, North Carolina) |
| ABSTRACT | An power converter includes an unfolder connected to a three-phase source and has an output connection with a positive terminal, a negative terminal and a neutral terminal. The unfolder creates two unipolar piece-wise sinusoidal DC voltage waveforms offset by a half of a period. A three-input converter connected to the unfolder produces a quasi-sinusoidal output voltage across output terminals. Switches of the converter selectively connect the positive, negative and neutral inputs across the output terminals. A PWM controller controls a first duty ratio and a second duty ratio for the converter based on a phase angle of the source and a modulation index generated from an error signal related to a control variable. The duty ratios are time varying with a fundamental frequency of the source. The modulation index relates to output voltage of the converter, peak voltage or current of the source and/or peak current at the output terminals. |
| FILED | Tuesday, October 12, 2021 |
| APPL NO | 17/499735 |
| CURRENT CPC | Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/007 (20210501) H02M 1/4216 (20130101) H02M 5/225 (20130101) H02M 5/2932 (20210501) Original (OR) Class H02M 7/5395 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230128829 | Young et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| INVENTOR(S) | Barbara Diane Young (Raymore, Missouri); Steven James Sedlock (Raymore, Missouri); Kevin Christopher Ledden (Raymore, Missouri); Alan Ahlberg Elliot (Lees Summit, Missouri) |
| ABSTRACT | A method for tuning a resonant frequency of wireless communication circuitry on a multichip module including a plurality of chips includes applying an electrical insulator to an upper surface of the multichip module; creating a plurality of openings in the electrical insulator, each opening being positioned at a successive one of the bond pads to be electrically connected to create a plurality of exposed bond pads; applying metal to each exposed bond pad to form a successive one of a plurality of interconnect bases; removing a portion of the layer of photoresist to create a plurality of bridge supports, each bridge support positioned between a successive pair of interconnect bases; applying metal to each bridge support and associated interconnect bases to form a successive one of the interconnect traces; removing the bridge supports; and disconnecting one or more of the interconnect traces as necessary to obtain a target resonant frequency. |
| FILED | Tuesday, October 26, 2021 |
| APPL NO | 17/511054 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 1/38 (20130101) H01Q 1/422 (20130101) H01Q 1/2283 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230128970 | Teeneti et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Chakridhar Reddy Teeneti (North Logan, Utah); Regan A. Zane (Hyde Park, Utah); Hongjie Wang (North Logan, Utah); Dorai Babu Yelaverthi (Raleigh, North Carolina) |
| ASSIGNEE(S) | Utah State University (Logan, Utah) |
| INVENTOR(S) | Chakridhar Reddy Teeneti (North Logan, Utah); Regan A. Zane (Hyde Park, Utah); Hongjie Wang (North Logan, Utah); Dorai Babu Yelaverthi (Raleigh, North Carolina) |
| ABSTRACT | A power converter includes an unfolder connected to a three-phase source and has an output connection with three output terminals. A three-input converter connected to the unfolder produces a quasi-sinusoidal output voltage across converter output terminals. Switches of the converter selectively connect each of the three output terminals across the converter output terminals. A pulse-width modulation controller controls a first duty ratio and a second duty ratio for the converter based on a phase angle of the source and a modulation index generated from an error signal related to a control variable. The duty ratios are time varying at a rate related to a fundamental frequency of the source. The modulation index relates to output voltage of the converter, peak voltage or current of the source and/or peak current at the output terminals. |
| FILED | Tuesday, October 18, 2022 |
| APPL NO | 17/968701 |
| CURRENT CPC | Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/007 (20210501) H02M 1/4216 (20130101) H02M 5/225 (20130101) H02M 5/2932 (20210501) Original (OR) Class H02M 7/5395 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230129915 | Young et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Honeywell Federal Manufacturing & Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Barbara D. Young (Raymore, Missouri); Jeffery J. Warger (Kansas City, Missouri) |
| ABSTRACT | Systems and methods for removing an oxide layer in an additive manufacturing process are provided. A direct write machine may be used to create wire bonds for semiconductors. The direct write machine may deposit a conductive print material between bond pads to create interconnections. The bond pads may comprise aluminum and an aluminum oxide layer on an outer surface. The presence of an aluminum oxide layer may decrease the electrical connection between the wire bond and the aluminum substrate. To remove the aluminum oxide layer, an abrasive tool is provided to ultrasonically abrade the aluminum oxide layer while the conductive print material is being deposited. The conductive print material may include abrasive additives materials to further aid in abrading the aluminum oxide layer. |
| FILED | Monday, October 25, 2021 |
| APPL NO | 17/509330 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/22 (20210101) B22F 10/38 (20210101) B22F 10/66 (20210101) Original (OR) Class B22F 2998/10 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 40/20 (20200101) B33Y 50/02 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230130721 | Nawaz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kashif Nawaz (Oak Ridge, Tennessee); Brian A. Fricke (Oak Ridge, Tennessee); Xin Sun (Oak Ridge, Tennessee) |
| ABSTRACT | A process for capturing carbon dioxide (CO2) present in a gas stream is provided. The process includes providing a cooling tower that treats a gas stream. The gas stream including CO2 is introduced into the cooling tower. A liquid carbon-dioxide-capturing media is released into the gas stream in the cooling tower. The carbon-dioxide-capturing media absorbs the CO2 in the gas stream, and the carbon-dioxide-capturing media including the absorbed CO2 is collected. An absorber for capture of CO2 in a gas stream is also provided. The absorber includes a cooling tower for treatment of a gas stream including CO2. The cooling tower includes an input for the gas stream, an outlet for a treated gas stream, and a sprayer that releases liquid carbon-dioxide-capturing media into the cooling tower. The carbon-dioxide-capturing media absorbs the CO2 from the gas stream in the cooling tower. A collector collects the carbon-dioxide-capturing media including absorbed CO2. |
| FILED | Wednesday, October 26, 2022 |
| APPL NO | 17/974232 |
| CURRENT CPC | Separation B01D 53/1425 (20130101) B01D 53/1475 (20130101) Original (OR) Class B01D 2221/16 (20130101) B01D 2252/103 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230131389 | Butko |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Anastasiia Butko (Alameda, California) |
| ABSTRACT | A Quantum Instruction Set Architecture (QUASAR) for quantum control processors, and a method which provides an interface for rapid and consistent development for controlling quantum computing systems which have different quantum computer chips and associated low-level control hardware. The method includes compiling a source program; decoding instructions by checking the opcode and determining whether said instruction is a single-qubit gate operation, a two-qubit gate operation, a measurement operation or a timing control operation; determining if each instruction is an immediate or register-based operation; decoding each specific instruction to generate machine code and/or netlists for execution by a quantum control unit configured for controlling a quantum computer chip and its associated low-level control hardware. |
| FILED | Thursday, October 20, 2022 |
| APPL NO | 18/048377 |
| CURRENT CPC | Electric Digital Data Processing G06F 8/51 (20130101) Original (OR) Class G06F 15/78 (20130101) Computer Systems Based on Specific Computational Models G06N 10/80 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230131728 | Deng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Z. Daniel Deng (Richland, Washington); Jun Lu (Richland, Washington); Jayson J. Martinez (Kennewick, Washington); Aljon L. Salalila (Richland, Washington); Mitchell J. Myjak (Richland, Washington); Hongfei Hou (Richland, Washington) |
| ABSTRACT | Sensor assemblies are provided for use in modeling water systems. These sensor assemblies can be used as sensor fish. These assemblies can include a circuit board supporting processing circuitry components on either or both opposing component support surfaces of the circuit board and a housing above the circuit board and the components, with the housing being circular about the circuit board in at least one cross section, and wherein the supporting surfaces of the circuit board are substantially parallel with the plane of the housing in the one cross section. Methods for emulating interaction of entities within water systems are provided. The methods can include introducing a sensor assembly into a water system. The sensor assembly can include: a circuit board supporting processing circuitry components on either or both of opposing component support surfaces of the circuit board; a housing about the circuit board and the components, the housing being circular about the circuit board in at least one cross section; and wherein the support surfaces of the circuit board are substantially parallel with the plane of the housing in the one cross section. |
| FILED | Thursday, November 03, 2022 |
| APPL NO | 17/980077 |
| CURRENT CPC | Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 19/148 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/0047 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 7/1427 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230131972 | Church et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George M. Church (Brookline, Massachusetts); Prashant G. Mali (La Jolla, California); Kevin M. Esvelt (Auburndale, Massachusetts) |
| ABSTRACT | Methods of modulating expression of a target nucleic acid in a cell are provided including introducing into the cell a first foreign nucleic acid encoding one or more RNAs complementary to DNA, wherein the DNA includes the target nucleic acid, introducing into the cell a second foreign nucleic acid encoding a nuclease-null Cas9 protein that binds to the DNA and is guided by the one or more RNAs, introducing into the cell a third foreign nucleic acid encoding a transcriptional regulator protein or domain, wherein the one or more RNAs, the nuclease-null Cas9 protein, and the transcriptional regulator protein or domain are expressed, wherein the one or more RNAs, the nuclease-null Cas9 protein and the transcriptional regulator protein or domain co-localize to the DNA and wherein the transcriptional regulator protein or domain regulates expression of the target nucleic acid. |
| FILED | Tuesday, October 25, 2022 |
| APPL NO | 17/972885 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/102 (20130101) C12N 15/113 (20130101) C12N 15/635 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2310/3513 (20130101) Enzymes C12Y 301/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230132031 | Snead et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (Albany, New York) |
| ASSIGNEE(S) | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (Albany, New York) |
| INVENTOR(S) | Lance Snead (Stony Brook, New York); Jason Trelewicz (Miller Place, New York) |
| ABSTRACT | A composite structure is disclosed comprising a neutron-absorbing metal hydride phase contained within a matrix having a density of greater than 95%. In various embodiments the metal hydride is a hydride of one or more of the following: Gadolinium, Hafnium, Europium, Samarium. The composite structure is utile as a shield for fusion or fission reactors. |
| FILED | Tuesday, March 23, 2021 |
| APPL NO | 17/914019 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 3/12 (20130101) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/053 (20130101) C04B 2235/44 (20130101) C04B 2235/77 (20130101) C04B 2235/3206 (20130101) Nuclear Reactors G21C 5/02 (20130101) G21C 5/12 (20130101) G21C 11/02 (20130101) Original (OR) Class Protection Against X-radiation, Gamma Radiation, Corpuscular Radiation or Particle Bombardment; Treating Radioactively Contaminated Material; Decontamination Arrangements Therefor G21F 1/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230132047 | Walsh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Vista Clara Inc. (Mukilteo, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Walsh (Shoreline, Washington); Elliot Grunewald (Seattle, Washington); Darya Morozov (Mill Creek, Washington) |
| ABSTRACT | Switched gradient field measurement techniques for SNMR are disclosed, as well as hardware and software that implements the disclosed techniques. The disclosed techniques allow directly imaging groundwater and hydrogeologic parameters at high resolution in the near subsurface. The resulting technology redefines practical capabilities for hydrogeologic imaging and shallow groundwater mapping, ultimately improving our ability understand, manage, and respond to critical zone processes. |
| FILED | Wednesday, October 19, 2022 |
| APPL NO | 18/047969 |
| CURRENT CPC | Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags G01V 3/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230132332 | Boxley et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GlycoSurf, Inc. (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chett Boxley (Park City, Utah); Ryan Stolley (Salt Lake City, Utah); Robert Bruggeman (Salt Lake City, Utah) |
| ABSTRACT | Methods of carbohydrate acetylation are disclosed. A method may include adding a carbohydrate to a reaction vessel, adding poly-4-vinylpyriding (P4VP) to the reaction vessel, adding a bio-derived solvent to the reaction vessel, adding acetic anhydride (Ac20) to the reaction vessel, and adding a catalyst to the reaction vessel. The bio-derived solvent may be 2-methyltetrahydrofuran (2-MeTHF). A catalyst may also be added to the reaction vessel. |
| FILED | Wednesday, October 12, 2022 |
| APPL NO | 17/964867 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/0244 (20130101) General Methods of Organic Chemistry; Apparatus Therefor C07B 41/12 (20130101) Original (OR) Class Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 11/08 (20130101) C08J 2439/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20230125667 | Bowroju et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government as represented by the Department of Veterans Affairs (Washington, None); BIOVENTURES, LLC (Little Rock, Arkansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Suresh Kuarm Bowroju (Little Rock, Arkansas); Peter Crooks (Little Rock, Arkansas); Narsimha Penthalla (Little Rock, Arkansas); Srinivas Ayyadevara (Little Rock, Arkansas); Monica Guzman (New York, New York); Robert J. J. Shmokler Reis (Little Rock, Arkansas); Eloisi Lopes (New York, New York); Samuel Kakraba (Little Rock, Arkansas) |
| ABSTRACT | The present disclosure is concerned with TDZD analogs for the treatment of various neurodegenerative diseases such as sarcopenia, supranuclear palsy, Alzheimer's disease, Parkinson's disease, Huntington's disease, and dementia, and various cancers such as, for example, sarcomas, carcinomas, hematological cancers, solid tumors, breast cancer, cervical cancer, gastrointestinal cancer, colorectal cancer, brain cancer, skin cancer, prostate cancer, ovarian cancer, bladder cancer, thyroid cancer, testicular cancer, pancreatic cancer, endometrial cancer, melanomas, gliomas, leukemias, lymphomas, chronic myeloproliferative disorders, myelodysplastic syndromes, myeloproliferative neoplasms, and plasma cell neoplasms (myelomas). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/799638 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) A61P 35/02 (20180101) Heterocyclic Compounds C07D 285/08 (20130101) Original (OR) Class C07D 417/12 (20130101) C07D 493/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230126533 | Mirsaeidi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of Miami (Miami, Florida); The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mehdi Mirsaeidi (Jacksonville, Florida); Chongxu Zhang (Riverside, Illinois); Andrew V. Schally (Miami Beach, Florida); Renzhi Cai (Fulshear, Texas); Runxia Tian (Palmetto Bay, Florida) |
| ABSTRACT | The present disclosure is directed to a method of treating an inflammatory disorder, such as sarcoidosis, using a growth hormone-releasing hormone (GHRH) antagonist. |
| FILED | Thursday, October 27, 2022 |
| APPL NO | 18/050355 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/25 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) A61P 29/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230126674 | Hansen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Howard Hansen (Apple Valley, Minnesota); Edwin Kay Iversen (Salt Lake City, Utah); Eric Alexander Nickel (Brooklyn Park, Minnesota); Gregory O. Voss (Apple Valley, Minnesota); Gregory James Jacobs (Salt Lake City, Utah); Carter J. Greene (West Valley City, Utah); Jeffery David Christenson (West Valley City, Utah) |
| ABSTRACT | Technology is described to provide a foot and ankle prosthesis for individuals with lower limb loss. This technology is able to store and release energy and individuals or patients who are using the foot/ankle prosthesis may be able to expend less energy when walking. The system includes a hydraulic damper attached to dynamic energy storing spring elements. The axis of rotation of the system can be near to that of an intact human ankle, providing biomimetic function. The system can utilize spring elements based on the vertical displacement of the center of pressure of an intact normal foot. A hydraulic system can provide user adjustable heel height and adaptation to inclines. The dorsiflexion and plantar flexion resistances can be independently adjusted manually or electrically. In addition, the system can be automatically locked in dorsiflexion when loaded and unlock when unloaded. |
| FILED | Thursday, October 21, 2021 |
| APPL NO | 17/507527 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/76 (20130101) Original (OR) Class A61F 2/744 (20210801) A61F 2/748 (20210801) A61F 2/6607 (20130101) A61F 2002/5006 (20130101) A61F 2002/6642 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230126976 | Zwerin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Suzanne M. Zwerin (Cincinnati, Ohio); David A. Parrott (Cincinnati, Ohio) |
| ABSTRACT | A plurality of inflatable pillows. Each pillow has at least one chamber. The chamber defines first and second edges oppositely disposed. Each pillow also has a valve providing fluid communication with the chamber for inflating and deflating the chamber. The first edge of one pillow is connect to a second edge of another pillow to form a continuous web. The pillows may form a continuous web and be dispensed from a device. Separation of the pillows one from another is enabled by perforations between edges of the pillows forming the web or tearing or cutting between edges of the pillows forming the web. |
| FILED | Tuesday, October 25, 2022 |
| APPL NO | 17/972808 |
| CURRENT CPC | Household or Table Equipment A47G 9/1027 (20130101) Original (OR) Class A47G 2009/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230127633 | Mehta et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia); Board of Trustees of the University of Arkansas (Little Rock, Arkansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jawahar L. Mehta (Little Rock, Arkansas); Magomed Khaidakov (Little Rock, Arkansas); Kottayil I. Varughese (Little Rock, Arkansas); Shraddha Thakkar (Little Rock, Arkansas); Yao Dai (Little Rock, Tennessee); Peter Crooks (Little Rock, Arkansas); Narsimha Reddy Penthala (Little Rock, Arkansas) |
| ABSTRACT | Inhibitors of oxidized low-density lipoprotein receptor 1 (LOX-1), compositions comprising inhibitors of LOX-1, and methods of using thereof are described. |
| FILED | Tuesday, October 11, 2022 |
| APPL NO | 17/964003 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/415 (20130101) A61K 31/4164 (20130101) Heterocyclic Compounds C07D 231/12 (20130101) Original (OR) Class C07D 231/14 (20130101) C07D 231/38 (20130101) C07D 233/22 (20130101) C07D 233/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230127834 | Friederich et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aidan Friederich (Cleveland Heights, Ohio); Ronald J. Triolo (Cleveland Heights, Ohio); Musa Audu (Shaker Heights, Ohio) |
| ABSTRACT | A trunk exoskeleton is provided including a flexible corset configured to wrap around a user's torso in the lumbar spine region. The flexible corset includes a plurality of vertical pockets formed around its perimeter. A plurality of flexor columns are included, each of which positioned in one of the plurality of vertical pockets. The flexor columns generate a flexor righting torque when bent from a vertical orientation. The multiple flexor righting torques from each of the plurality of flexor columns combine to generate a combined flexor righting torque. The combined flexor righting torque comprises a portion of a user trunk torque when the user's torso is angled from vertical. |
| FILED | Wednesday, October 26, 2022 |
| APPL NO | 17/973605 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 5/028 (20130101) Original (OR) Class A61F 2005/0179 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0452 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230129574 | Alva |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jessica Alva (Richmond, Virginia) |
| ABSTRACT | Technologies are provided for remote neuropsychological assessments and other types of remote assessments (medical or otherwise). |
| FILED | Wednesday, October 26, 2022 |
| APPL NO | 17/974129 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/16 (20130101) A61B 5/0077 (20130101) A61B 5/4803 (20130101) A61B 5/7445 (20130101) A61B 5/7465 (20130101) Original (OR) Class A61B 2505/07 (20130101) A61B 2560/0431 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 40/67 (20180101) Transmission of Digital Information, e.g Telegraphic Communication H04L 65/1069 (20130101) Pictorial Communication, e.g Television H04N 5/247 (20130101) H04N 5/2257 (20130101) H04N 7/183 (20130101) Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 1/1008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230130791 | Habib |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amyn A. Habib (Dallas, Texas) |
| ABSTRACT | The present disclosure is concerned with modulators of EGFR and modulators of Nrf2 for treating various cancers such as, for example, sarcomas, carcinomas, hematological cancers, solid tumors, breast cancer, cervical cancer, gastrointestinal cancer, colorectal cancer, brain cancer, skin cancer, prostate cancer, ovarian cancer, bladder cancer, thyroid cancer, testicular cancer, pancreatic cancer, endometrial cancer, melanomas, gliomas, leukemias, lymphomas, chronic myeloproliferative disorders, myelodysplastic syndromes, myeloproliferative neoplasms, and plasma cell neoplasms (myelomas). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| FILED | Wednesday, March 10, 2021 |
| APPL NO | 17/910637 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/44 (20130101) A61K 31/427 (20130101) A61K 31/517 (20130101) Original (OR) Class A61K 31/655 (20130101) A61K 31/4409 (20130101) A61K 39/3955 (20130101) A61K 2039/545 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230130831 | ACHILEFU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Samuel ACHILEFU (St. Louis, Missouri); Christine PHAM (St. Louis, Missouri); Shaw-Wei TSEN (St. Louis, Missouri) |
| ABSTRACT | The present disclosure provides a method of detecting a joint disease, the method comprising administering a composition comprising an agent chosen from LS301, LS838, or a derivative thereof to a subject in need thereof; and detecting a signal intensity emitted from the agent in at least one joint of the subject, wherein detection of signal intensity above a baseline value indicates the subject has the joint disease. Also are provided are methods for monitoring the progression of a joint disease, monitoring treatment response to a therapeutic agent for treating a joint disease, and treating a joint disease. |
| FILED | Tuesday, October 25, 2022 |
| APPL NO | 18/049504 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) A61K 31/573 (20130101) A61K 49/0032 (20130101) A61K 49/0056 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20230126288 | Murphey et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Opteru Research and Development, Inc. (Fort Collins, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas W Murphey (Fort Collins, Colorado); Levi Nicholson (Wellington, Colorado); Michael Folkers (Fort Collins, Colorado); Erik Pranckh (Fort Collins, Colorado); Kyle Egan (Fort Collins, Colorado) |
| ABSTRACT | A deformable support apparatus includes a deformable body configured to transition between at least an extended state and a contracted state where a stiffness of the deformable body in the extended state is greater than a corresponding stiffness of the deformable body in the contracted state. The deformable body includes a first member and a second member coupled to and in opposition to the first member, and arranged about a longitudinal axis. In the extended state, the first member has at least a first curved portion and the second member has at least a second curved portion. The at least a first curved portion is a positive curved portion with respect to the longitudinal axis and the at least a second curved portion is a negative curved portion with respect to the longitudinal axis. |
| FILED | Wednesday, December 21, 2022 |
| APPL NO | 18/086189 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/222 (20130101) B64G 1/407 (20130101) B64G 1/443 (20130101) B64G 99/00 (20220801) Original (OR) Class Structural Elements; Building Materials E04C 3/005 (20130101) E04C 3/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230129191 | Hill et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Cory J. Hill (Chesterfield, Missouri); Harold Frank Greer (Los Angeles, California) |
| ABSTRACT | Disclosed herein is a method of producing an infrared detector. In certain embodiments, the method includes: forming a planar multi-layer structure including an absorber including a superlattice structure; patterning the planar multi-layer structure; etching the planar multi-layer structure to define a plurality of pixels, the sidewalls of the plurality of pixels includes a sidewall roughness and multiple types of surface oxides; and performing a surface treatment process to the plurality of pixels in order to reduce the sidewall roughness and replace the surface oxides with a chlorinated surface morphology. The surface treatment process may reduce surface current of the infrared detector which may decrease the dark current in the infrared detector. |
| FILED | Tuesday, October 25, 2022 |
| APPL NO | 18/049424 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/14649 (20130101) H01L 27/14694 (20130101) H01L 27/14698 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230131584 | Bayer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mustafa Mert Bayer (Irvine, California); Ozdal Boyraz (Irvine, California) |
| ABSTRACT | Various examples for multi-tone continuous wave detection and ranging are disclosed herein. In some embodiments, an initial signal is generated using initial radio frequency (RF) tones, and is emitted as a multi-tone continuous wave signal. The initial signal is reflected from a target and received as a reflected signal. Resultant RF tones, including a frequency, a phase and a power, are determined from the reflected signal in a frequency domain. A frequency-domain sinusoidal wave is fitted to the resultant RF tones in the frequency domain, and a distance to the target is determined using a modulation of the frequency-domain sinusoidal wave. A phase processing algorithm is applied to generate the target distance and speed by triangulating the range information encoded in the backscattered RF tones. |
| FILED | Friday, September 03, 2021 |
| APPL NO | 17/467012 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 13/584 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20230127880 | Redden |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Blue River Technology Inc. (Sunnyvale, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lee Kamp Redden (Palo Alto, California) |
| ABSTRACT | Described are methods for identifying the in-field positions of plant features on a plant by plant basis. These positions are determined based on images captured as a vehicle (e.g., tractor, sprayer, etc.) including one or more cameras travels through the field along a row of crops. The in-field positions of the plant features are useful for a variety of purposes including, for example, generating three-dimensional data models of plants growing in the field, assessing plant growth and phenotypic features, determining what kinds of treatments to apply including both where to apply the treatments and how much, determining whether to remove weeds or other undesirable plants, and so on. |
| FILED | Thursday, December 15, 2022 |
| APPL NO | 18/082312 |
| CURRENT CPC | Electric Digital Data Processing G06F 18/2415 (20230101) Image Data Processing or Generation, in General G06T 7/593 (20170101) Image or Video Recognition or Understanding G06V 10/764 (20220101) G06V 20/38 (20220101) G06V 20/188 (20220101) Pictorial Communication, e.g Television H04N 13/128 (20180501) H04N 13/204 (20180501) H04N 13/239 (20180501) H04N 13/243 (20180501) Original (OR) Class H04N 13/271 (20180501) H04N 2013/0081 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230127944 | BURNS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Venatorx Pharmaceuticals, Inc. (Malvern, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher J. BURNS (Malvern, Pennsylvania); Guo-Hua CHU (Exton, Pennsylvania); Jodie HAMRICK (New Holland, Pennsylvania); Steven A. BOYD (Chester Springs, Pennsylvania); Stephen M. CONDON (Glenmoore, Pennsylvania) |
| ABSTRACT | The present disclosure provides broad-spectrum carbapenem derivatives and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such derivatives and/or compositions. |
| FILED | Thursday, September 17, 2020 |
| APPL NO | 17/778199 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/2013 (20130101) A61K 9/2018 (20130101) A61K 9/2054 (20130101) A61K 9/2059 (20130101) A61K 9/4825 (20130101) A61K 9/4858 (20130101) A61K 31/69 (20130101) A61K 31/407 (20130101) Original (OR) Class A61K 31/454 (20130101) A61K 31/506 (20130101) A61K 31/4439 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Heterocyclic Compounds C07D 477/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230128072 | Sykora |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Amelia Technologies (Washington D.C., District of Columbia) |
| ASSIGNEE(S) | Amelia Technologies (Washington D.C., District of Columbia) |
| INVENTOR(S) | Peter Sykora (Baltimore, Maryland) |
| ABSTRACT | Composition, systems, and methods for the induction of biological endpoints in a cheap contained system. In many embodiments, variation on well numbers on plates and ranging ultraviolet wavelengths produces different and controlled outcomes of the biological endpoint induction. Endpoint induction of this type allows for chemical induction, wherein the system can be turned on and off in short time periods. |
| FILED | Saturday, September 24, 2022 |
| APPL NO | 17/935093 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/06 (20130101) Original (OR) Class Non-electric Light Sources Using Luminescence; Light Sources Using Electrochemiluminescence; Light Sources Using Charges of Combustible Material; Light Sources Using Semiconductor Devices as Light-generating Elements; Light Sources Not Otherwise Provided for F21K 9/64 (20160801) Indexing Scheme Associated With Subclasses F21K, F21L, F21S and F21V, Relating to the Form or the Kind of the Light Sources or of the Colour of the Light Emitted F21Y 2115/10 (20160801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20230127686 | HAY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | WILLIAM T. HAY (PEORIA, Illinois); DAVID A. SCHISLER (MORTON, Illinois); GORDON W. SELLING (DUNLAP, Illinois); GEORGE F. FANTA (MORTON, Illinois); FRED J. ELLER (PEORIA, Illinois); JOSEPH O. RICH (PEORIA, Illinois) |
| ABSTRACT | Provided herein are fatty-ammonium salt/starch inclusion complexes comprising one or more of a variety of fatty amines. Such complexes can be combined with film-forming agents, such as poly(vinyl) alcohol (PVOH) and plasticizing agents. The inclusion complexes of the present invention can be utilized as antimicrobial agents, preventing microbial growth on organic and inorganic surfaces. In specific embodiments, inclusion complexes of the present invention are applied to vegetable or fruit surfaces in order to impede microbial growth. Inclusion complexes of the present invention can be applied to wood in order to impede microbial growth and insect consumption and to wound dressings. |
| FILED | Thursday, December 22, 2022 |
| APPL NO | 18/087088 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 43/16 (20130101) Original (OR) Class Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 15/28 (20130101) A61L 15/42 (20130101) A61L 2300/404 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230131883 | NEMSER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | COMPACT MEMBRANE SYSTEMS, INC. (Newport, Delaware) |
| ASSIGNEE(S) | |
| INVENTOR(S) | STUART MARSHALL NEMSER (Wilmington, Delaware); SUDIPTO MAJUMDAR (Newark, Delaware); NING SHANGGUAN (Cherry Hill, New Jersey) |
| ABSTRACT | A method for removing ethylene from the atmosphere surrounding an agricultural product that is sensitive to ethylene, which promotes climacteric ripening and senescence, is disclosed. The method uses a membrane for selective ethylene permeation and removal from a container that is used to store, transport, and preserve the agricultural product. |
| FILED | Friday, March 26, 2021 |
| APPL NO | 17/914152 |
| CURRENT CPC | Preserving, e.g by Canning, Meat, Fish, Eggs, Fruit, Vegetables, Edible Seeds; Chemical Ripening of Fruit or Vegetables; the Preserved, Ripened, or Canned Products A23B 7/148 (20130101) Separation B01D 53/229 (20130101) Original (OR) Class B01D 69/12 (20130101) B01D 71/022 (20130101) B01D 71/32 (20130101) B01D 71/66 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20230129562 | TRAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland); The Regents of the University of Colorado, a body corporate (Denver, Colorado); Government of the United States of America as Represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Minh C. TRAN (College Park, Maryland); Abhinav DESHPANDE (College Park, Maryland); Andrew Y. GUO (College Park, Maryland); Andrew LUCAS (Boulder, Colorado); Alexey GORSHKOV (Potomac, Maryland) |
| ABSTRACT | A system for quantum state transfer and entanglement generation includes a quantum system including a plurality of qubits, a processor, and a memory. The memory includes instructions stored thereon, which, when executed by the processor, cause the quantum system to: access a signal of the quantum system; encode unknown coefficients in one qubit of the plurality of qubits; initialize each of the remaining qubits of the plurality of qubits in state |0 |
| FILED | Tuesday, October 04, 2022 |
| APPL NO | 17/959901 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/20 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20230127343 | Conley et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Melissa Conley (Washington, District of Columbia); John Fortune (Clifton, Virginia); Michael Chandarlis (Woodbridge, Virginia); William Garrett (Morehead, Kentucky); Brian Lewis (Washington, District of Columbia) |
| ABSTRACT | Described herein are examples of evaluating electromagnetic energy reflection data of security scans. In embodiments, a method to evaluate electromagnetic energy reflection data determines whether electronic information of a security scan contains an anomaly, and identifies an anomaly location in the electronic information corresponding to the anomaly. The method determines a subset of the electronic information corresponding to the anomaly location, determines anomaly attributes using the subset of the electronic information, and evaluates the anomaly attributes using a database of reference items by comparing anomaly attributes to respective reference characteristics of reference items or identity information. When a comparison meets the respective match criterion for the given reference item, the method assigns to the anomaly the respective identifier as an anomaly identifier. |
| FILED | Thursday, June 17, 2021 |
| APPL NO | 17/350926 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/412 (20130101) Original (OR) Class Electric Digital Data Processing G06F 18/22 (20230101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 50/265 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 20230126364 | Kummetha et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vishal Chandra Kummetha (Tampa, Florida); Mohsen Kamrani (Lutz, Florida); Sisinnio Concas (Tampa, Florida) |
| ABSTRACT | A method for traffic congestion detection for a roadway facility having a plurality of segments includes receiving travel time data from at least one travel time data source for a plurality of predetermined time intervals and determining a travel time index (TTI) for each time interval based on the travel time data associated with the time interval. The method further includes determining a change in travel time index (TTI) intensity between two successive time intervals for each pair of successive time intervals in the plurality of time intervals, applying a signal processing filter to the determined change in travel time index intensity to generate a filter value for each time interval; and determining a congestion level for each time interval based on the filter value for each time interval and a predetermined set of congestion level thresholds. |
| FILED | Monday, October 24, 2022 |
| APPL NO | 17/971758 |
| CURRENT CPC | Traffic Control Systems G08G 1/0112 (20130101) G08G 1/0133 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Environmental Protection Agency (EPA)
| US 20230127819 | TOWNSEND et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Timothy G TOWNSEND (GAINESVILLE, Florida); John Alfred BOWDEN (NEWBERRY, Florida); Michael D ANNABLE (GAINESVILLE, Florida); Nicole ROBEY (GAINESVILLE, Florida) |
| ABSTRACT | The present disclosure provides for devices, systems, and methods of separating PFAS compounds from wastewater leachate. After separation, the PFAS compounds can be rendered less harmful. The present disclosure provides for devices, systems, and methods that uses aeration-induced foaming to isolate PFAS from landfill leachate into a concentrated, volume reduced liquid (coalesced foam), which can be separated and treated. |
| FILED | Tuesday, March 16, 2021 |
| APPL NO | 17/911903 |
| CURRENT CPC | Separation B01D 21/0027 (20130101) B01D 21/0042 (20130101) B01D 21/0084 (20130101) B01D 21/2411 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/24 (20130101) Original (OR) Class C02F 1/40 (20130101) C02F 2101/36 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20230129463 | Bonnell et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Clayton C. Bonnell (Fairfax, Virginia); Kelley A. Sullivan (Washington, District of Columbia) |
| ABSTRACT | Methods and systems for electronic document authentication are disclosed. In one aspect, a method of generating an electronic postmark includes receiving, via a server, a request message from an electronic network, the request message comprising request data including payload data and meta data, generating a timestamp in response to receiving the message, hashing the payload data to generate a payload hash, digitally signing the metadata, the payload hash, and the timestamp to generate a digital signature, generating a response message, the response message generated to comprise the metadata, the payload hash, the timestamp, and the digital signature; and transmitting the response message onto the electronic network. |
| FILED | Monday, December 19, 2022 |
| APPL NO | 18/068027 |
| CURRENT CPC | Postal Sorting; Sorting Individual Articles, or Bulk Material Fit to be Sorted Piece-meal, e.g by Picking B07C 1/00 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 20/102 (20130101) G06Q 20/3827 (20130101) G06Q 30/0283 (20130101) G06Q 50/32 (20130101) G06Q 2220/00 (20130101) G06Q 2250/05 (20130101) G06Q 2250/30 (20130101) G06Q 2250/60 (20130101) G06Q 2250/905 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/32 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20230125840 | Rutar |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina) |
| ASSIGNEE(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina) |
| INVENTOR(S) | Matej Rutar (Manchester, Connecticut) |
| ABSTRACT | In accordance with at least one aspect of this disclosure, a variable displacement pump system can include, a variable displacement pump disposed in a main line and configured to supply pressure to receive a low pressure fluid and to output a high pressure fluid. The main line can connect a hydraulic fluid source to a plurality of system actuators, where the variable displacement pump is disposed in the main line between the hydraulic fluid source and the plurality of system actuators to pressurize the hydraulic fluid. |
| FILED | Friday, October 22, 2021 |
| APPL NO | 17/508600 |
| CURRENT CPC | Positive-displacement Machines for Liquids; Pumps F04B 49/08 (20130101) F04B 49/065 (20130101) F04B 49/246 (20130101) Original (OR) Class F04B 2205/05 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230128586 | GRANINGER |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AURELIUS L. GRANINGER (Sykesville, Maryland) |
| ASSIGNEE(S) | NORTHROP GRUMMAN SYSTEMS CORPORATION (FALLS CHURCH, Virginia) |
| INVENTOR(S) | AURELIUS L. GRANINGER (Sykesville, Maryland) |
| ABSTRACT | A superconducting DC switch system is provided. The superconducting DC switch system comprises one or more Josephson junctions (JJs), and a magnetic field generator that is configured to switch from inducing a magnetic field in a plane of the one or more JJs, and providing no magnetic field in the plane of the one or more JJs. A DC input signal applied at an input of the one or more JJs is passed through to an output the one or more JJs in the absence of an induced magnetic field, and the DC input signal is substantially suppressed at the output of the one or more JJs in the presence of the magnetic field. |
| FILED | Wednesday, July 14, 2021 |
| APPL NO | 17/375199 |
| CURRENT CPC | Pulse Technique H03K 17/92 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230130997 | Rutar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina) |
| ASSIGNEE(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina) |
| INVENTOR(S) | Matej Rutar (Manchester, Connecticut); Morgan O'Rorke (West Hartford, Connecticut); Ryan Shook (Rockford, Illinois); Ryan Susca (Windsor, Connecticut) |
| ABSTRACT | In accordance with at least one aspect of this disclosure, a variable displacement pump system can include, a variable displacement pump disposed in a main line and configured to supply pressure to receive a low pressure fluid and to output a high pressure fluid. The main line can connect a hydraulic fluid source to a plurality of system actuators, where the variable displacement pump is disposed in the main line between the hydraulic fluid source and the plurality of system actuators to pressurize the hydraulic fluid. |
| FILED | Friday, October 22, 2021 |
| APPL NO | 17/508058 |
| CURRENT CPC | Positive-displacement Machines for Liquids; Pumps F04B 19/04 (20130101) F04B 49/12 (20130101) Original (OR) Class F04B 49/24 (20130101) F04B 53/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230132157 | OLSON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Westinghouse Electric Company LLC (Cranberry Township, Pennsylvania) |
| ASSIGNEE(S) | Westinghouse Electric Company LLC (Cranberry Township, Pennsylvania) |
| INVENTOR(S) | Luke C. OLSON (Columbia, South Carolina); Kathryn E. METZGER (Columbia, South Carolina); Edward J. LAHODA (Pittsburgh, Pennsylvania); Elwyn ROBERTS (Lugoff, South Carolina); Michael R. ICKES (West Homestead, Pennsylvania); Paolo FERRONI (Pittsburgh, Pennsylvania); Denise Adorno LOPES (Västerås, Sweden); Luke D. CZERNIAK (North Huntingdon, Pennsylvania); Fausto FRANCESCHINI (Lerici, Italy) |
| ABSTRACT | Annular nuclear fuel rods are disclosed. The annular nuclear fuel rods include an outer cladding tube made of ceramic composite or cermet composite, an inner cladding tube made of ceramic composite or cermet composite, a nuclear fuel region located between the outer cladding tube and inner cladding tube, and an open channel for liquid coolant to flow. |
| FILED | Thursday, October 21, 2021 |
| APPL NO | 17/451726 |
| CURRENT CPC | Nuclear Reactors G21C 3/07 (20130101) Original (OR) Class G21C 3/10 (20130101) G21C 3/16 (20130101) G21C 3/42 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, April 27, 2023.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20230427.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page