FedInvent™ Patent Applications
Application Details for Thursday, May 04, 2023
This page was updated on Thursday, May 04, 2023 at 10:23 AM GMT
Department of Health and Human Services (HHS)
| US 20230132569 | Sontheimer et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MASSACHUSETTS (Baston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Erik J. Sontheimer (Auburndale, Massachusetts); Yan Zhang (Shrewsbury, Massachusetts) |
| ABSTRACT | Many strains of the human pathogen Neisseria meningitidis carry a compact Cas9 (NmeCas9) that can serve to limit genetic exchange via natural transformation. Cas9 orthologues (including NmeCas9) have recently been adopted for RNA-guided genome engineering and DNA binding, adding to the need to define better their activities and properties. The present invention examines DNA cleavage activities and substrate requirements of NmeCas9, including a set of unusually complex PAM recognition patterns. Unexpectedly, NmeCas9 is found able to cleave single-stranded DNA (ssDNA) targets in a manner that is RNA-guided but both PAM- and tracrRNA-independent. Beyond the requirement for guide-target pairing, this activity has no apparent sequence requirements, and the cleavage sites are measured from the 5′ end of the DNA substrate's RNA-paired region. These results indicate that tracrRNA domains are not strictly required for enzymatic activation of NmeCas9, and expand the list of targeting activities exhibited by these revolutionary RNA-guided nucleases. |
| FILED | Thursday, July 21, 2022 |
| APPL NO | 17/870336 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/11 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230132588 | Letzt et al. |
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| APPLICANT(S) | Healthcare Technologies and Methods, LLC (Fredericksburg, Virginia) |
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| INVENTOR(S) | Alan Letzt (Purcellville, Virginia); Stephanie Letzt (Purcellville, Virginia) |
| ABSTRACT | A system, device, and wireless computer technology-implemented method for providing hearing healthcare education and communication for a patient, his/her communication partner, and a hearing care provider. The system provides the patient at least one educational and experiential module and a method for assessing the patient's comprehension of the module's lessons. The system further provides the patient with a method to select personal hearing aid and communication goals; a method to evaluate his/her progress on achieving each personal goal; and a method to report his/her hearing experiences. The system further provides a method to compare data reported by the patient to personalized thresholds. When one or more of the patient's reports do not meet the thresholds, the system sends automated alerts to the hearing care provider to encourage prompt remedial action and sends automated reminders to the patient to improve the patient's ability to achieve his/her personal goals. |
| FILED | Wednesday, December 28, 2022 |
| APPL NO | 18/090263 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/123 (20130101) A61B 5/4833 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 7/00 (20130101) G09B 19/00 (20130101) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/00 (20180101) G16H 40/67 (20180101) Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 25/70 (20130101) H04R 2225/55 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230132602 | PLACE et al. |
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| APPLICANT(S) | miRecule, Inc. (Gaithersburg, Maryland) |
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| INVENTOR(S) | Robert PLACE (Gaithersburg, Maryland); Anthony SALEH (Gaithersburg, Maryland); Tishan WILLIAMS (Gaithersburg, Maryland) |
| ABSTRACT | Disclosed herein are engineered oligonucleotides for selective inhibition of polypeptide expression and activity. Also disclosed herein are methods of selectively inhibiting polypeptide expression and activity contacting an engineered oligonucleotide with a polynucleotide encoding the polypeptide. |
| FILED | Friday, April 02, 2021 |
| APPL NO | 17/915215 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/549 (20170801) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/33 (20130101) C12N 2310/141 (20130101) C12N 2310/316 (20130101) C12N 2310/321 (20130101) C12N 2310/322 (20130101) C12N 2310/351 (20130101) C12N 2310/531 (20130101) C12N 2310/3521 (20130101) C12N 2320/31 (20130101) C12N 2320/32 (20130101) C12N 2320/35 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230132667 | Shortridge et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| ASSIGNEE(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| INVENTOR(S) | Matthew Shortridge (Seattle, Washington); Gabriele Varani (Seattle, Washington); Venkata Vidadala (Seattle, Washington) |
| ABSTRACT | Methods for identifying selective RNA-binding small molecules by NMR screening. The method provides a screening cascade to identify molecules that bind to an RNA structure, such as HIV TAR. Compounds that bind to structured RNAs and that are useful to disrupt the formation of RNA-protein complexes, such as P-TEFb-Tat-TAR complex. |
| FILED | Tuesday, May 25, 2021 |
| APPL NO | 17/999545 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Heterocyclic Compounds C07D 471/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
20230132819 — SYSTEM AND METHOD FOR ELECTROMAGNETIC INTERFERENCE MITIGATION FOR PORTABLE MRI SYSTEMS
| US 20230132819 | Wald et al. |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
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| INVENTOR(S) | Lawrence L. Wald (Cambridge, Massachusetts); Clarissa Zimmerman-Cooley (Boston, Massachusetts); Sai Abitha Srinivas (Boston, Massachusetts); Stephen Cauley (Cambridge, Massachusetts) |
| ABSTRACT | Electromagnetic interference (“EMI”) is mitigated for portable magnetic resonance imaging (“MRI”) systems using postprocessing interference suppression techniques that make use of EMI detectors external to the MRI system imaging volume to detect EMI signals and remove them from acquired magnetic resonance data. EMI correction models, including static transfer function-based models, dynamic transfer function-based models, correction weight-based models, or parallel imaging kernel-based models can be used to remove the EMI-related artifacts from the magnetic resonance data. |
| FILED | Monday, April 26, 2021 |
| APPL NO | 17/996856 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/44 (20130101) G01R 33/422 (20130101) G01R 33/5608 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230132854 | Thorson et al. |
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| APPLICANT(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jon S. Thorson (Lexington, Kentucky); Jurgen Rohr (Lexington, Kentucky); Markos Leggas (Lexington, Kentucky); Joseph M. Eckenrode (Lexington, Kentucky); Yinan Zhang (Nanjing, Jiangsu, China PRC); Yang Liu (Lexington, Kentucky); Jianjun Zhang (Lexington, Kentucky); Khaled Attia Shaaban Mahmoud (Lexington, Kentucky) |
| ABSTRACT | Compounds described herein are mithramycin (MTM) oxide (OX) derivatives. These compounds are useful for treatment of cancers and neuro-diseases. |
| FILED | Tuesday, October 11, 2022 |
| APPL NO | 17/963537 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 15/26 (20130101) C07H 15/244 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230133011 | LOPACHIN et al. |
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| APPLICANT(S) | MONTEFIORE MEDICAL CENTER (Bronx, New York) |
| ASSIGNEE(S) | MONTEFIORE MEDICAL CENTER (Bronx, New York) |
| INVENTOR(S) | Richard M. LOPACHIN (New Rochelle, New York); Terrence GAVIN (, None); Brian GEOHAGEN (Bronx, New York) |
| ABSTRACT | Methods, filters and compositions are disclosed for treating toxicity due to oxidative stress and toxic electrophiles. |
| FILED | Tuesday, August 02, 2022 |
| APPL NO | 17/816980 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0226 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/05 (20130101) A61K 31/12 (20130101) Original (OR) Class A61K 31/36 (20130101) A61K 31/095 (20130101) A61K 31/167 (20130101) A61K 31/381 (20130101) A61K 31/402 (20130101) A61K 31/495 (20130101) A61K 31/5375 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 39/06 (20180101) Acyclic or Carbocyclic Compounds C07C 49/80 (20130101) C07C 49/84 (20130101) C07C 49/807 (20130101) C07C 49/825 (20130101) C07C 233/33 (20130101) C07C 323/22 (20130101) Heterocyclic Compounds C07D 207/04 (20130101) C07D 207/325 (20130101) C07D 295/112 (20130101) C07D 333/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230133022 | Hochberg et al. |
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| FUNDED BY |
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| APPLICANT(S) | BROWN UNIVERSITY (Providence, Rhode Island); THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
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| INVENTOR(S) | Leigh Hochberg (East Greenwich, Rhode Island); John D. Simeral (Providence, Rhode Island); Tyler Singer-Clark (Falmouth, Massachusetts); Ronnie Gross (Portsmouth, Rhode Island); Thomas Hosman (Providence, Rhode Island); Anastasia Kapitonava (Boston, Massachusetts) |
| ABSTRACT | Instances of a single brain computer interface (BCI) system can be implemented on multiple devices. An active instance can control the associated device. The instances can each communicate with a neural decoding system that can receive neural signals from a user, process the neural signals, and output a command based on the processed neural signals. A device running the active instance of can be in communication with the neural decoding system to receive a command. The device can include a display, a non-transitory memory storing instructions, and a processor to execute the instructions to: run an instance of a control program; and execute the task based on the command. |
| FILED | Tuesday, November 01, 2022 |
| APPL NO | 17/978271 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/015 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230133243 | Lieber et al. |
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| APPLICANT(S) | Fred Hutchinson Cancer Center (Seattle, Washington); University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | Fred Hutchinson Cancer Center (Seattle, Washington); University of Washington (Seattle, Washington) |
| INVENTOR(S) | Andre Lieber (Seattle, Washington); Hans-Peter Kiem (Seattle, Washington) |
| ABSTRACT | The present disclosure provides, among other things, immune suppression regimens for in vivo gene therapy and uses thereof. In various embodiments of the present disclosure, in vivo gene therapy includes delivery of at least one exogenous coding nucleic acid sequence to a stem cell of the subject. Success of in vivo gene therapy can be inhibited or reduced by immunotoxicity. The present disclosure provides compositions and methods, including among other things immune suppression regimens, that reduce immunotoxicity of in vivo gene therapy, e.g., in vivo gene therapy including administration of a viral gene therapy vector to a subject. |
| FILED | Monday, April 12, 2021 |
| APPL NO | 17/995687 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/395 (20130101) A61K 31/436 (20130101) A61K 31/573 (20130101) A61K 38/193 (20130101) A61K 38/2006 (20130101) A61K 39/3955 (20130101) A61K 48/0083 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/06 (20180101) A61P 37/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230133386 | Wang et al. |
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| APPLICANT(S) | Rensselaer Polytechnic Institute (Troy, New York) |
| ASSIGNEE(S) | Rensselaer Polytechnic Institute (Troy, New York) |
| INVENTOR(S) | Ge Wang (Loudonville, New York); Mengzhou Li (Troy, New York); Zheng Fang (Troy, New York); Wenxiang Cong (Albany, New York) |
| ABSTRACT | In one embodiment, there is provided a micro-CT (computed tomography) apparatus. The micro-CT apparatus includes an x-ray source coupled to a source robotic arm, an x-ray detector coupled to a detector robotic arm, and a computing device. The computing device includes a data acquisition module and a reconstruction module. The data acquisition module is configured to acquire local scan data of a volume of interest (VOI) contained in an imaging object. The reconstruction module is configured to reconstruct an image of the VOI based, at least in part, on the local scan data, and based, at least in part, on background compensation data. |
| FILED | Friday, November 04, 2022 |
| APPL NO | 17/980948 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/035 (20130101) Original (OR) Class A61B 6/4241 (20130101) A61B 6/4417 (20130101) A61B 6/4458 (20130101) A61B 6/5205 (20130101) A61B 6/5235 (20130101) A61B 6/5258 (20130101) Image Data Processing or Generation, in General G06T 11/005 (20130101) G06T 2211/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230133695 | GOLDMAN et al. |
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| APPLICANT(S) | University of Rochester (Rochester, New York) |
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| INVENTOR(S) | Steven A. GOLDMAN (Webster, New York); John N. Mariani (Rochester, New York); Abdellatif Benraiss (Rochester, New York) |
| ABSTRACT | The present disclosure is directed to methods of inducing rejuvenation in a population of adult glial progenitor cells, and methods of treating a subject having a myelin deficiency. The method of inducing rejuvenation in a population of adult glial progenitor cells may comprise administering, to the population of adult glial progenitor cells, an effective amount of an agent that suppresses one or more transcription factors selected from the group consisting of (i) zinc finger protein 274 (ZNF274), (ii) Myc-associated factor X (MAX), (iii) E2F transcription factor 6 (E2F6), (iv) zinc finger protein Aiolos (IKZF3), and (v) signal transducer and activator of transcription 3 (STAT3). |
| FILED | Wednesday, October 19, 2022 |
| APPL NO | 18/047749 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/141 (20130101) C12N 2320/35 (20130101) C12N 2740/15032 (20130101) C12N 2740/15043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230133958 | Whitehead et al. |
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| APPLICANT(S) | Mekanistic Therapeutics LLC (Ann Arbor, Michigan) |
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| INVENTOR(S) | Christopher E. Whitehead (Ypsilanti, Michigan); Judith S. Leopold (Ann Arbor, Michigan) |
| ABSTRACT | The present invention relates to the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a quinazoline structure or a quinoline structure according to Formula I, wherein L, R1, R2, X1, X2, and X3 are described herein, which function as dual inhibitors of EGFR proteins and PI3K proteins. The invention further relates to their use as therapeutics for the treatment of EGFR and/or PI3K mediated diseases or conditions. |
| FILED | Thursday, October 20, 2022 |
| APPL NO | 17/970443 |
| CURRENT CPC | Heterocyclic Compounds C07D 401/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230134238 | Tebon et al. |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
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| INVENTOR(S) | Peyton J. Tebon (Los Angeles, California); Darin Williams (Sun Valley, California) |
| ABSTRACT | The present invention provides fluidic (both air and liquid) exchange systems configured to retrofit standard cell/tissue culture well plates (6, 12, 24, 48, 96, 384, 1536 wells, and the like) and petri dishes by plugging into the openings of each well or dish. |
| FILED | Friday, March 12, 2021 |
| APPL NO | 17/906087 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/563 (20130101) Original (OR) Class B01L 2200/026 (20130101) B01L 2200/0689 (20130101) B01L 2300/0829 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230134467 | Pederson et al. |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts); University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thoru Pederson (Worcester, Massachusetts); Hanhui Ma (Shrewsbury, Massachusetts); Li-Chun Tu (Worcester, Massachusetts); Ardalan Naseri (Orlando, Florida); Maximilaan Huisman (Worcester, Massachusetts); Shaojie Zhang (Orlando, Florida) |
| ABSTRACT | A C9orf72 DNA repeat expansion can be detected using a CRISPR Arrayed Repeat Detection System (CARDS). Based upon the compositions and methods supporting this platform primary cell cultures and/or blood cell smears can be tested under conventional clinical diagnostic laboratory conditions to diagnose genetically-based diseases having DNA repeat expansions, including but not limited to ALS. dCas9 constructs are also contemplated as having fluorescent proteins bound to any or all stem loop sequences, wherein detection of a plurality of dCas9 constructs having different colored fluorescent proteins can simultaneously detect at least six (6) different gene target loci. |
| FILED | Wednesday, July 06, 2022 |
| APPL NO | 17/858717 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/85 (20130101) C12N 2310/20 (20170501) C12N 2310/3519 (20130101) C12N 2830/003 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6816 (20130101) Original (OR) Class C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230134587 | Iribarren et al. |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sarah J. Iribarren (Seattle, Washington); Barry R. Lutz (Seattle, Washington); Daniel Leon (Seattle, Washington); Marcus Rhodehamel (Seattle, Washington); Jesse Keyes (Seattle, Washington); Hannah Erdy (Seattle, Washington); Mohamed Adil (Seattle, Washington); Rishika Das (Seattle, Washington); Kyle Goodwin (Seattle, Washington) |
| ABSTRACT | Embodiments disclosed herein relate to apparatuses, systems, and methods for detecting biomarkers in biological samples present in assay tests using a control strip and indicator strip, where the control strip includes reagents that form a reactive gas which reacts with the biomarker on the indicator strip, if present. Methods of using the test apparatuses include taking a sending photographs of a used test apparatus to a medical provider to demonstrate adherence to a pharmaceutical treatment regimen. |
| FILED | Monday, August 15, 2022 |
| APPL NO | 17/888335 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/01 (20130101) G01N 33/493 (20130101) G01N 33/5038 (20130101) Original (OR) Class G01N 2021/0118 (20130101) G01N 2033/4975 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230134760 | Wang et al. |
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| APPLICANT(S) | Hongbing Wang (Ellicott City, Maryland); Fengtian Xue (Potomac, Maryland); Linhao LI (Ellicott City, Maryland) |
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| INVENTOR(S) | Hongbing Wang (Ellicott City, Maryland); Fengtian Xue (Potomac, Maryland); Linhao LI (Ellicott City, Maryland) |
| ABSTRACT | The disclosure relates to selective small molecule dual activators of human constitutive androstane receptor (hCAR) and nuclear factor erythroid 2-related factor 2 (Nrf2), pharmaceutical compositions thereof, and use thereof for the treatment of hematologic malignancies and other cancers. The small molecule dual hCAR and Nrf2 activators in combination with CPA based chemotherapy regimen provides a synergistic effect to help promote cytoxicity of the cyclophosphamide (CPA) based and doxorubicin (DOX) based anticancer treatments including CHOP regimen (CPA, doxorubicin, vincristine, and prednisone) while reducing cardiotoxicity associated with DOX. |
| FILED | Thursday, March 04, 2021 |
| APPL NO | 17/909334 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/424 (20130101) A61K 31/429 (20130101) Original (OR) Class A61K 31/475 (20130101) A61K 31/573 (20130101) A61K 31/675 (20130101) A61K 31/704 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 498/04 (20130101) C07D 513/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230134844 | Mekonnen et al. |
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| FUNDED BY |
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| APPLICANT(S) | AGENEBIO, INC. (BALTIMORE, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Belew Mekonnen (Gilbertsville, Pennsylvania); John A. Butera (Clarksburg, New Jersey); Jianxing Huang (Bethlehem, Pennsylvania); Hemantbhai Patel (Piscataway, New Jersey) |
| ABSTRACT | This invention relates to benzodiazepine derivatives, compositions comprising therapeutically effective amounts of those benzodiazepine derivatives and methods of using those derivatives or compositions in treating cognitive impairment associated with central nervous system (CNS) disorders. In particular, it relates to the use of a α5-containing GABAA receptor agonist (e.g., a α5-containing GABAA receptor positive allosteric modulator) as described herein in treating cognitive impairment associated with central nervous system (CNS) disorders in a subject in need or at risk thereof, including, without limitation, subjects having or at risk for age-related cognitive impairment, Mild Cognitive Impairment (MCI), amnestic MCI (aMCI), Age-Associated Memory Impairment (AAMI), Age Related Cognitive Decline (ARCD), dementia, Alzheimer's Disease(AD), prodromal AD, post traumatic stress disorder (PTSD), schizophrenia, bipolar disorder, amyotrophic lateral sclerosis (ALS), cancer-therapy-related cognitive impairment, mental retardation, Parkinson's disease (PD), autism spectrum disorders, fragile X disorder, Rett syndrome, compulsive behavior, and substance addiction. It also relates to the use of a α5-containing GABAA receptor agonist (e.g., a α5-containing GABAA receptor positive allosteric modulator) as described herein in treating brain cancers (including brain tumors, e.g., medulloblastomas), and cognitive impairment associated therewith. |
| FILED | Friday, September 02, 2022 |
| APPL NO | 17/902374 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Heterocyclic Compounds C07D 487/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230134886 | Pennypacker et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Keith R. Pennypacker (Lexington, Kentucky); Justin F. Fraser (Lexington, Kentucky); Qiang Cheng (Lexington, Kentucky) |
| ABSTRACT | The presently-disclosed subject matter generally to methods for identifying and analyzing biomarkers to determine group effects. The presently-disclosed subject matter also relates to methods for identifying genes and proteins that increase or decrease in response to ischemic stroke damage. The disclosed subject matter further describes methods of predicting edema and infarct volume in a patient. Also described herein are methods of determining the necessity of intervention for smokers. Further disclosed herein, are methods for testing therapies for ischemic stroke. |
| FILED | Tuesday, October 13, 2020 |
| APPL NO | 17/768181 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 2600/158 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 25/10 (20190201) G16B 40/20 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/30 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230134917 | AMANOV et al. |
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| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee); Virtuoso Surgical, Inc. (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ernar AMANOV (Nashville, Tennessee); Dominick ROPELLA (Nashville, Tennessee); Naren NIMMAGADDA (Nashville, Tennessee); Nicholas KAVOUSSI (Nashville, Tennessee); Neal DILLON (Nashville, Tennessee); Richard HENDRICK (Nashville, Tennessee); Stanley HERRELL (Nashville, Tennessee); Robert WEBSTER (Nashville, Tennessee) |
| ABSTRACT | A surgical system, method, and apparatus for suturing a first anatomical structure to a second anatomical structure of a subject includes an endoscope tube for being advanced through a lumen of the first anatomical structure to a surgical site near the second anatomical structure. A manipulator arm extends through the endoscope tube to the surgical site, and includes a first concentric tube manipulator with an end effector configured to grasp and manipulate a suture at the surgical site. A needle arm extends through the endoscope tube to the surgical site, and includes a second concentric tube manipulator with a needle tip configured to pierce the tissue of the first and second anatomical structures. The needle arm is also configured to grasp the suture and to retract and pull the suture through the pierced tissue so that the suture extends through and forms stitching that stitches together the first and second anatomical structures. |
| FILED | Tuesday, March 09, 2021 |
| APPL NO | 17/910735 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/015 (20130101) A61B 1/053 (20130101) A61B 17/29 (20130101) A61B 17/0469 (20130101) Original (OR) Class A61B 34/30 (20160201) A61B 2017/00353 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230134986 | LIU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland); Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences (Shanghai, China PRC) |
| ASSIGNEE(S) | |
| INVENTOR(S) | JUN O. LIU (Baltimore, Maryland); EMMANUEL DATAN (Baltimore, Maryland); MARTIN GILBERT POMPER (Baltimore, Maryland); IL MINN (Baltimore, Maryland); PENG XU (Shanghai, China PRC); BIAO YU (Shanghai, China PRC) |
| ABSTRACT | A major hurdle in the treatment of cancer is chemoresistance induced under hypoxia that is characteristic of tumor microenvironment. Triptolide, a potent inhibitor of eukaryotic transcription, possesses potent antitumor activity. However, its clinical potential has been limited by toxicity and water solubility. To address those limitations of triptolide, the present disclosure designed and synthesized glucose-triptolide conjugates (glutriptolides) and demonstrated their antitumor activity in vitro and in vivo. The glutriptolides disclosed herein possess improved stability in human serum, greater selectivity towards cancer over normal cells and increased potency against cancer cells. Importantly, the glutriptolides are more potent against cancer cells under hypoxic conditions in contrast to existing cytotoxic drugs. These glutriptolides also exhibit sustained antitumor activity, prolonging survival in a prostate cancer metastasis animal model. Together, these findings suggest a new strategy to overcome chemoresistance through conjugation of cytotoxic agents to glucose. |
| FILED | Tuesday, March 02, 2021 |
| APPL NO | 17/801509 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) A61K 47/549 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 1/00 (20130101) C07H 15/26 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230135002 | Yeo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eugene Yeo (La Jolla, California); Eric Van Nostrand (La Jolla, California) |
| ABSTRACT | Provided are methods of determining RNA translation rate in a biological sample, for example by crosslinking an RNA binding protein (RBP) to an RNA in a biological sample; identifying an RNA-RNA binding protein (RBP) complex within the biological sample, wherein the RNA-RBP complex comprises an RNA fragment bound by the RNA binding protein; and profiling the RNA fragment bound by the RNA binding protein, thereby determining a translation rate of the RNA in the biological sample. |
| FILED | Tuesday, March 30, 2021 |
| APPL NO | 17/915167 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6804 (20130101) C12Q 1/6844 (20130101) C12Q 1/6869 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230135464 | Cramer, Jr. et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert A. Cramer, Jr. (Hanover, New Hampshire); Caitlin Kowalski (Hanover, New Hampshire) |
| ABSTRACT | Filamentous fungal host cells expressing hypoxia responsive morphology factor A (hrmA) and biofilm architecture factor (baf) proteins are provided. Methods of producing filamentous fungal host cells expressing hrmA and baf proteins are also provided. In one aspect, the disclosure provides a filamentous fungal host cell, comprising a nucleotide sequence encoding an Aspergillus fumigatus hypoxia responsive morphology factor A (hrmA) protein, or a homolog or ortholog thereof. |
| FILED | Friday, September 11, 2020 |
| APPL NO | 17/642592 |
| CURRENT CPC | Peptides C07K 14/38 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/52 (20130101) C12N 15/80 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230135524 | Gryder et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland); Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland); Georgia Tech Research Corporation (Atlanta, Georgia) |
| INVENTOR(S) | Berkley E. Gryder (Wickliffe, Ohio); Adegboyega K. Oyelere (Marietta, Georgia); Subhasish Tapadar (Atlanta, Georgia); Jonathan D. Strope (Hyattsville, Maryland); William Douglas Figg, Sr. (Tierra Verde, Florida) |
| ABSTRACT | Disclosed is a compound of formula (I) in which R1, R2, R3, X1, X2, X2′, X3, X4, ring A, m, n, and o are as described herein. The compound of formula (I) is useful for treating a disorder associated with androgen receptor malfunction, such as a hyperproliferative disorder, in a subject in need thereof. |
| FILED | Wednesday, January 20, 2021 |
| APPL NO | 17/794212 |
| CURRENT CPC | Heterocyclic Compounds C07D 401/14 (20130101) C07D 403/06 (20130101) C07D 403/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230135635 | COSFORD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SALK INSTITUTE FOR BIOLOGICAL STUDIES (La Jolla, California); SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas D.P. COSFORD (La Jolla, California); Nicole A. BAKAS (La Jolla, California); Mitchell VAMOS (La Jolla, California); Reuben J. SHAW (La Jolla, California); Allison S. LIMPERT (La Jolla, California); Sonja N. BRUN (La Jolla, California) |
| ABSTRACT | The present disclosure is directed to compounds, compositions, formulations and methods of use thereof in the treatment and prevention of ULK mediated diseases, including cancer. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/799639 |
| CURRENT CPC | Heterocyclic Compounds C07D 401/12 (20130101) C07D 401/14 (20130101) C07D 405/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230135822 | LUO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MEMORIAL SLOAN KETTERING CANCER CENTER (New York, New York) |
| ASSIGNEE(S) | MEMORIAL SLOAN KETTERING CANCER CENTER (New York, New York) |
| INVENTOR(S) | Minkui LUO (New York, New York); Xiaochuan CAI (New York, New York); Ke WANG (New York, New York); Junyi WANG (New York, New York) |
| ABSTRACT | Compounds having methyltransferase inhibitory activity are disclosed. The compounds have the structures The compounds disclosed are useful in the treatment of cancer and similar diseases associated with inappropriate methyltransferase activity. |
| FILED | Monday, September 26, 2022 |
| APPL NO | 17/935304 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7076 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 19/16 (20130101) C07H 19/167 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230135826 | Smith, III et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amos B Smith, III (Merion Station, Pennsylvania); Kevin T O'Brien (Sicklerville, New Jersey); Jonathan W Nadraws (Philadelphia, Pennsylvania) |
| ABSTRACT | Organodifluorine synthons, in conjunction with three-component diastereoselective Anion Relay Chemistry (ARC), permit ready access to diverse difluoromethylene scaffolds. Initiated via [1,2]-addition of an organolithium reagent to a β-difluoromethylene silyl aldehyde, an alkoxide intermediate is formed, which is capable of undergoing a [1,4]-Brook rearrangement to generate a stabilized α-difluoromethylene carbanion, which upon electrophile capture, affords a three-component adduct. This three-component synthetic tactic represents an important one-pot divergent strategy for the construction of diverse organodifluorine containing compounds. |
| FILED | Tuesday, November 01, 2022 |
| APPL NO | 18/051549 |
| CURRENT CPC | Heterocyclic Compounds C07D 307/20 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/10 (20130101) C07F 7/081 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230136080 | FERRARA |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Napoleone FERRARA (San Diego, California) |
| ABSTRACT | Compositions and methods for treating a VEGF-related ophthalmic disorder in a subject in need comprising, administering intravitreally to the subject a therapeutically effective amount of an anti-VEGF agent, comprising a VEGF binding portion operatively linked to a Fc-IgG, wherein the VEGF binding portion comprises at least one VEGF binding domain that is an IgG-like domain 2 of VEGFR-1. |
| FILED | Wednesday, July 20, 2022 |
| APPL NO | 17/813889 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0048 (20130101) A61K 38/179 (20130101) Original (OR) Class A61K 39/001109 (20180801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) Peptides C07K 14/71 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230136350 | Brudno et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina); The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yevgeny Brudno (Cary, North Carolina); Pritha Agarwalla (Raleigh, North Carolina); Gianpietro Dotti (Chapel Hill, North Carolina) |
| ABSTRACT | Disclosed are compositions and methods for a low cost, tunable, macroporous, alginate scaffold that transduces T cells with vectors under static condition. |
| FILED | Monday, April 12, 2021 |
| APPL NO | 17/917770 |
| CURRENT CPC | Peptides C07K 14/7051 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0068 (20130101) C12N 5/0636 (20130101) C12N 15/87 (20130101) Original (OR) Class C12N 2510/00 (20130101) C12N 2533/74 (20130101) C12N 2740/16043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230136466 | LENG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | FENFEI LENG (PALMETTO BAY, Florida); EDDY ALFONSO (MIAMI, Florida); ZIFANG DENG (MIAMI, Florida) |
| ASSIGNEE(S) | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (MIAMI, Florida) |
| INVENTOR(S) | FENFEI LENG (PALMETTO BAY, Florida); EDDY ALFONSO (MIAMI, Florida); ZIFANG DENG (MIAMI, Florida) |
| ABSTRACT | The subject invention provides fluorophore-quencher nucleic acid molecules comprising relaxed or supercoiled DNA molecules, and their use in rapid and efficient high-throughput screening (HTS) assays to screen and identify compounds that inhibit DNA gyrases. These compounds can be used as antibiotics for treating bacterial infections, especially, multidrug resistant bacterial infections. |
| FILED | Tuesday, September 13, 2022 |
| APPL NO | 17/944006 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/24 (20130101) A61K 31/52 (20130101) A61K 31/185 (20130101) A61K 31/192 (20130101) A61K 31/196 (20130101) A61K 31/352 (20130101) A61K 31/366 (20130101) A61K 31/381 (20130101) A61K 31/404 (20130101) A61K 31/427 (20130101) A61K 31/429 (20130101) A61K 31/433 (20130101) A61K 31/443 (20130101) A61K 31/473 (20130101) A61K 31/475 (20130101) A61K 31/496 (20130101) A61K 31/498 (20130101) A61K 31/513 (20130101) A61K 31/519 (20130101) A61K 31/4155 (20130101) A61K 31/4184 (20130101) A61K 31/4196 (20130101) A61K 31/5377 (20130101) A61K 31/7048 (20130101) Original (OR) Class A61K 31/7076 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230136594 | Mitsuya et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hiroaki Mitsuya (Kumamoto, Japan); Arun K. Ghosh (West Lafayette, Indiana); Satish Kovela (West Lafayette, Indiana) |
| ABSTRACT | Compounds of formula (I), pharmaceutical compositions comprising compounds of the formula (I), and methods of treating an HIV infection comprising administering an effective amount of one or more compounds of formula (I), or a pharmaceutical composition comprising same. |
| FILED | Monday, January 18, 2021 |
| APPL NO | 17/906604 |
| CURRENT CPC | Heterocyclic Compounds C07D 493/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230136613 | VALAFAR et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | San Diego State University (SDSU) Foundation, dba San Diego State University Research Foundation (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Faramarz VALAFAR (San Diego, California); Samuel James MODLIN (San Diego, California); Sarah M. RADECKE (San Diego, California); Emma WESTIN (San Diego, California); Deepika GUNASEKARAN (Dublin, California) |
| ABSTRACT | In alternative embodiments, provided are products of manufacture and kits, and methods, that comprise or comprise use of inhibitory molecules for treating or ameliorating, or providing clinical decision support for the treatment of, a bacterial infection, for example, a Mycobacterium tuberculosis (MTB) infection, or an infection by any member species of the M. tuberculosis (MTBC) complex. In alternative embodiments, the inhibitory molecules inhibit the expression of one or more of the 38 PE/PPE MTB genes as identified herein, or one or more of the 366 identical MTB genes and proteins common to a global set of MTB isolates as identified herein, or the inhibitory molecules inhibit the expression of a transcript or a polypeptide gene product thereof, or inhibit the changing (and hence evading the immune system) of one or more of the 52 special immune-evading MTB PE/PPE genes as identified herein |
| FILED | Friday, March 26, 2021 |
| APPL NO | 17/914662 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) Original (OR) Class A61K 31/7125 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230136619 | Bremer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Prelude Corporation (Laguna Hills, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Troy M. Bremer (Irvine, California); Steven Paul Linke (Carlsbad, California) |
| ABSTRACT | The present technology generally relates to methods and compositions relevant to the prediction that a subject with and/or after treatment for DCIS will experience a subsequent ipsilateral breast event that is a DCIS recurrence, an invasive breast cancer, both a DCIS recurrence and invasive cancer, or neither. The technology can assist one with how to treat such subjects. |
| FILED | Thursday, February 24, 2022 |
| APPL NO | 17/652466 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57415 (20130101) Original (OR) Class G01N 33/57488 (20130101) G01N 2333/82 (20130101) G01N 2333/723 (20130101) G01N 2333/9108 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230136666 | Lee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chi Hwan Lee (West Lafayette, Indiana); Laurent Couetil (West Lafayette, Indiana); Tae Hoo Chang (Beavercreek, Ohio); Semih Akin (West Lafayette, Indiana); Martin Byung-Guk Jun (West Lafayette, Indiana) |
| ABSTRACT | Electronic textiles and methods of fabrication electronic textiles. Nanoparticles of a conductive material are sprayed along a conductive path into a fabric material so as to penetrate into the fabric. A layer of a second conductor material is coated over the nanoparticles along the conductive path. A layer of an insulator material is coated over the layer of the second conductor material so as to encapsulate the conductive path and form a trace. An electrode configured to contact a subject wearing the fabric material includes a layer of a third conductor material coated over the layer of the second conductor and electrically coupled with the conductive path. An electrical connector is secured to the fabric material and electrically coupled with the conductive path. The nanoparticles are sprayed onto the fabric material using a dual regime spray process implemented with a dual regime spray system. |
| FILED | Monday, August 29, 2022 |
| APPL NO | 17/823021 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/27 (20210101) A61B 2503/40 (20130101) A61B 2562/0215 (20170801) A61B 2562/0285 (20130101) Treating Textile Materials Using Liquids, Gases or Vapours D06B 11/0059 (20130101) Treatment, Not Provided for Elsewhere in Class D06, of Fibres, Threads, Yarns, Fabrics, Feathers or Fibrous Goods Made From Such Materials D06M 11/65 (20130101) D06M 11/83 (20130101) D06M 15/693 (20130101) D06M 23/08 (20130101) D06M 2101/06 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 3/28 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/038 (20130101) Original (OR) Class H05K 1/092 (20130101) H05K 3/14 (20130101) H05K 2201/10151 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230136730 | Markowitz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Dallas, Texas); CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sanford Markowitz (Pepper Pike, Ohio); James K.V. Willson (Dallas, Texas); Bruce Posner (Richardson, Texas); Joseph Ready (Carrollton, Texas); Monika Antczak (Ft. Worth, Texas); Yongyou Zhang (Cleveland, Ohio); Amar Desai (Cleveland, Ohio); Stanton Gerson (Hunting Valley, Ohio); William Greenlee (Cleveland, Ohio); Sung Yeun Yang (Busan, South Korea); KiBeom Bae (Busan, South Korea) |
| ABSTRACT | Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein. |
| FILED | Tuesday, August 02, 2022 |
| APPL NO | 17/879379 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/437 (20130101) A61K 31/444 (20130101) A61K 31/496 (20130101) A61K 31/519 (20130101) A61K 31/4365 (20130101) A61K 31/5377 (20130101) Original (OR) Class Heterocyclic Compounds C07D 495/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230136830 | Wald et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lawrence L. Wald (Cambridge, Massachusetts); Clarissa Zimmerman-Cooley (Boston, Massachusetts); Patrick C. McDaniel (Boston, Massachusetts) |
| ABSTRACT | A single-sided magnet and magnetic resonance imaging (“MRI”) system are portable and lightweight, enabling use as a point-of care (“POC”) MRI device. The portable MRI system includes a magnet assembly containing layers of magnet blocks, such as rare-earth magnet blocks. The magnet blocks are arranged in concentric rings in each layer, and surround a central aperture extending through the magnet assembly. The central aperture is sized to allow a medical instrument, such as a needle, to pass through the central aperture. The portable MRI system can therefore be used for image guidance in lumbar puncture (“LP”) and other medical procedures. |
| FILED | Monday, April 26, 2021 |
| APPL NO | 17/996852 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/004 (20130101) A61B 5/055 (20130101) A61B 34/20 (20160201) Original (OR) Class A61B 2017/3405 (20130101) A61B 2560/0431 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/383 (20130101) G01R 33/385 (20130101) G01R 33/3808 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230136849 | Srivastava et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| INVENTOR(S) | Arun Srivastava (Gainesville, Florida); George Vladimirovich Aslanidi (Gainesville, Florida); Sergei Zolotukhin (Gainesville, Florida); Mavis Agbandje-McKenna (Gainesville, Florida); Kim M. Van Vliet (Gainesville, Florida); Li Zhong (Gainesville, Florida); Lakshmanan Govindasamy (Gainesville, Florida) |
| ABSTRACT | Disclosed are capsid-modified rAAV expression vectors, as well as infectious virions, compositions, and pharmaceutical formulations containing them. Also provided are methods of preparing and using the disclosed capsid-protein-mutated rAAV constructs in a variety of diagnostic and therapeutic modalities, including, inter alia, as mammalian cell-targeting delivery agents, and as human gene therapy vectors. Also disclosed are large-scale production methods for capsid-modified rAAV expression vectors, viral particles, and infectious virions having improved transduction efficiencies over those of the corresponding, un-modified, rAAV vectors, as well as use of the disclosed compositions in the manufacture of medicaments for a variety of in vitro and/or in vivo applications. |
| FILED | Thursday, September 01, 2022 |
| APPL NO | 17/929256 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/42 (20130101) Peptides C07K 14/005 (20130101) Original (OR) Class C07K 14/015 (20130101) C07K 14/805 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2750/14122 (20130101) C12N 2750/14143 (20130101) C12N 2750/14145 (20130101) C12N 2750/14171 (20130101) C12N 2810/6027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230136997 | Frank et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Children's Medical Center Corporation (Boston, Massachusetts); The Brigham and Woman's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Children's Medical Center Corporation (Boston, Massachusetts); The Brigham and Woman's Hospital, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Markus H. Frank (Cambridge, Massachusetts); Natasha Y. Frank (Cambridge, Massachusetts) |
| ABSTRACT | The present invention is directed to methods and compositions for treating Glioblastoma multiforme (GBM). The risk of developing therapy resistant GBM may be assessed by detecting the presence of ABCB5 in the GBM cells. Therapeutic interventions utilizing an ABCB5 blockade to sensitize the GBM cells to therapeutic agents such as temozolomide are provided. |
| FILED | Wednesday, April 14, 2021 |
| APPL NO | 17/918479 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/495 (20130101) A61K 39/3955 (20130101) Original (OR) Class A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) A61P 35/00 (20180101) Peptides C07K 16/28 (20130101) C07K 16/40 (20130101) C07K 16/3053 (20130101) C07K 2317/31 (20130101) C07K 2317/622 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230137331 | Milone et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania); THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael C. Milone (Cherry Hill, New Jersey); Lance C. Kam (New York, New York); Keyue Shen (Cambridge, Massachusetts); Xueli Hao (Cleveland, Ohio); Roderick O'Connor (Philadelphia, Pennsylvania); Geraldine Goebrecht (La Jolla, California) |
| ABSTRACT | The present invention provides compositions and methods for activation and expansion of T cells using a biocompatible solid substrate with tunable rigidity. Rigidity of a substrate is an important parameter that can be used to control the overall expansion and differentiation of T cells. |
| FILED | Monday, June 13, 2022 |
| APPL NO | 17/839397 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 2035/124 (20130101) Peptides C07K 16/2809 (20130101) C07K 16/2818 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 2501/51 (20130101) C12N 2501/515 (20130101) C12N 2527/00 (20130101) C12N 2531/00 (20130101) C12N 2539/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230137548 | ANNALA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CITY OF HOPE (Duarte, California) |
| ASSIGNEE(S) | CITY OF HOPE (Duarte, California) |
| INVENTOR(S) | Alexandra Jacqueline ANNALA (Arcadia, California); Karen ABOODY (Arcadia, California); Jennifer COVELLO (Fontana, California); Rachael MOONEY (Monument, California) |
| ABSTRACT | Provided are methods and compositions for treating cancer with a combination of neural stem cells (NSCs) and an oncolytic virus or a combination of oncolytic virotherapy and immune modulation. The method entails administrating to a subject a pharmaceutical composition comprising a combination of NSCs and an oncolytic virus, and/or NSCs packaged with one or more immunomodulatory viruses expressing one or more immunity checkpoint inhibitors, including adaptive immunity checkpoint inhibitors and innate immunity checkpoint inhibitors. The immunity checkpoint inhibitors include shRNAs against the immunity checkpoint proteins. The cancer includes but is not limited to primary, recurrent, and metastatic brain cancer, breast cancer, head and neck cancer, bladder cancer, ovarian cancer, uterine cancer, prostate cancer, skin cancer, lung cancer, and colorectal cancer. |
| FILED | Monday, July 11, 2022 |
| APPL NO | 17/811851 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7105 (20130101) A61K 35/30 (20130101) Original (OR) Class A61K 35/761 (20130101) A61K 45/05 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230137667 | Baric et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina); Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ralph Baric (Haw River, North Carolina); Amy Sims (Richland, Washington); Hugh D. Mitchell (Richland, Washington); Katrina M. Waters (Richland, Washington) |
| ABSTRACT | The present invention provides methods and compositions for treating coronavirus infection and diseases and disorders associated with or caused by coronavirus infection. |
| FILED | Friday, March 19, 2021 |
| APPL NO | 17/906560 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/662 (20130101) A61K 31/7056 (20130101) Original (OR) Class A61K 31/7076 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230137773 | VERDINE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregory L. VERDINE (Boston, Massachusetts); John Hanney MCGEE (Somerville, Massachusetts) |
| ABSTRACT | The present invention provides peptides comprising a sequence of X-6X-5X-4X-3X-2X-1X1PX3X4PX6X7PGX10X11AX13X14X15X16LX18X19X20X21X22X23LX25X26YLX29X30X31X32 wherein the amino acids X-6, X-5, X-4, X-3, X-2, X-1, X1, X3, X4, X6, X7, X10, X11, X13, X14, X15, X16, X18, X19, X20, X21, X22, X25, X26, X29, X30, X31, and X32 are as defined herein. The present invention further provides pharmaceutical compositions comprising the peptides and methods of using the peptides for treating proliferative diseases such as cancer which are associated with Ras. Also provided are methods of screening a library of peptide dimers using a peptide dimer display technology. |
| FILED | Monday, May 23, 2022 |
| APPL NO | 17/751451 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/16 (20130101) A61K 38/22 (20130101) Peptides C07K 7/06 (20130101) C07K 7/08 (20130101) C07K 14/00 (20130101) C07K 14/82 (20130101) C07K 14/575 (20130101) C07K 14/4703 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1037 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230137794 | Golestani-Rad et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Laleh Golestani-Rad (Wilmette, Illinois); Behzad Elahi (Chicago, Illinois); Jasmine Christina Vu (Evanston, Illinois) |
| ABSTRACT | A system to predict heating in implants includes a memory configured to store an image of a patient. The image includes a medical implant of the patient. The system also includes a processor operatively coupled to the memory and configured to determine an implant trajectory of the medical implant. The processor is also configured to determine a tangential component of an electric field that is incident upon the medical implant at a plurality of locations along the implant trajectory. The processor is further configured to determine, based on the implant trajectory and the tangential component of the electric field at each of the plurality of locations, a specific absorption rate of radiofrequency (RF) energy associated with the medical implant. |
| FILED | Thursday, April 22, 2021 |
| APPL NO | 17/918260 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230137843 | ODETE et al. |
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| FUNDED BY |
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| APPLICANT(S) | SPHERYX, INC. (New York, New York) |
| ASSIGNEE(S) | SPHERYX, INC. (New York, New York) |
| INVENTOR(S) | Mary Ann ODETE (New York, New York); Rostislav BOLTYANSKIY (Brooklyn, New York); Fook Chiong CHEONG (New York, New York); Laura A. PHILIPS (New York, New York) |
| ABSTRACT | A holographic microscopy characterization (HMC) process for utilizing holographic video microscopy to provide an efficient, automated, label-free method of accurately identifying cell viability. Optical properties of a sample of cells are determined by HMC. The optical properties are compared to known samples or compared over time to observe changes in the optical properties, enabling identification of cells as viable or not viable, or as extra-cellular or degraded cellular materials. |
| FILED | Friday, October 28, 2022 |
| APPL NO | 17/976565 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/0227 (20130101) Holographic Processes or Apparatus G03H 1/0005 (20130101) Original (OR) Class G03H 2001/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230137874 | Sridharan et al. |
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| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arati Sridharan (Chandler, Arizona); Jitendran Muthuswamy (Chandler, Arizona) |
| ABSTRACT | A soft conductive composition can include: a crosslinked silicone composition; and single-walled or multi-walled carbon nanotubes in the silicone composition. A neural probe or other implant can include the soft conducive composition on a least a portion of the implant body. A method of making an implant can include: selecting PDMS precursors; cross-linking the PDMS precursor to obtain an elastic modulus of about 3-9 kPa or +/− 1%, 5%, 10%, 20%, or 50%; selecting the carbon nanotubes; introducing the carbon nanotubes into the crosslinked PDMS to form a soft conductive composite composition; and coating the soft conductive composite composition onto at least a portion of an implant. A method of measuring properties at a neural interface can include: providing a neural probe having a soft conductive composition; implanting the neural probe having the soft conductive composition at a neural interface; and measuring a property with the neural probe. |
| FILED | Friday, December 23, 2022 |
| APPL NO | 18/146333 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/686 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/174 (20170801) Original (OR) Class Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/041 (20170501) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 7/61 (20180101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230137893 | GNEDEVA et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Rockefeller University (New York, New York) |
| ASSIGNEE(S) | The Rockefeller University (New York, New York) |
| INVENTOR(S) | Ksenia GNEDEVA (Malibu, California); A. James HUDSPETH (New York, New York); Nathaniel KASTAN (New York, New York); Rui LIANG (East Brunswick, New Jersey); Peter T. MEINKE (Scotch Plains, New Jersey); David John HUGGINS (New York, New York); Nigel John LIVERTON (San Antonio, Texas); Leigh Ashley BAXT (New York, New York); John David GINN (New York, New York); Robert Walter MYERS (Cresskill, New Jersey) |
| ABSTRACT | N-(3-Substituted thiazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamides and N-(3-substituted oxazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamides are disclosed. The compounds activate Yap and inhibit Lats kinases. They are therefore useful for treating hearing loss. |
| FILED | Friday, February 05, 2021 |
| APPL NO | 17/760143 |
| CURRENT CPC | Heterocyclic Compounds C07D 471/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230137943 | Moellering et al. |
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| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Raymond E. Moellering (Chicago, None); David C. McCutcheon (Chicago, None); Anthony Carlos (Chicago, Illinois) |
| ABSTRACT | Photoactive probes and probe systems for detecting biological interactions are described. The photoactive probes include probes that combine both photocleavable and photoreactive moieties. The photoactive probe systems can include a first probe comprising a photocatalytic group and a second probe comprising a group that can act as a substrate for the reaction catalyzed by the photocatalytic group. The probes and probe systems can also include groups that can specifically bind to a binding partner on a biological entity of interest and a detectable group or a precursor thereof. The probes and probe systems can detect spatiotemporal interactions of proteins or cells. In some embodiments, the interactions can be detected in live cells. Also described are methods of detecting the biological interactions. |
| FILED | Monday, September 21, 2020 |
| APPL NO | 17/762180 |
| CURRENT CPC | Heterocyclic Compounds C07D 519/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/582 (20130101) Original (OR) Class G01N 33/6845 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230138177 | IAVARONE et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Antonio IAVARONE (Sunny Isles Beach, Florida); Anna LASORELLA (New York, New York) |
| ABSTRACT | The subject matter described herein relates to a method of regulating protein kinase activity by allosteric modifications such as prolyl hydroxylation. |
| FILED | Friday, December 30, 2022 |
| APPL NO | 18/148841 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0071 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/485 (20130101) Original (OR) Class Enzymes C12Y 114/11029 (20130101) C12Y 207/12001 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2333/912 (20130101) G01N 2440/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230138178 | Cronce et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Michael Cronce (Berkeley, California); Jeffrey S. Cox (San Francisco, California); Jay D. Keasling (Berkeley, California) |
| ABSTRACT | The present invention provides for a genetically modified gut bacterial cell capable of producing an antiviral compound. The genetically modified gut bacterial cell can be introduced to a subject to colonize the gastrointestinal tract of the subject, produce the antiviral compound and increase resistance to a virus infection. |
| FILED | Friday, June 24, 2022 |
| APPL NO | 17/849327 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/74 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/12 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/74 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230138309 | Krishna et al. |
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| FUNDED BY |
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| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Sri Krishna (North Bethesda, Maryland); Frank J. Lowery, III (Clarksburg, Maryland); Ken-ichi Hanada (Bethesda, Maryland); James C. Yang (Bethesda, Maryland); Steven A. Rosenberg (Potomac, Maryland); Paul F. Robbins (Chevy Chase, Maryland); Rami Yoseph (Gaithersburg, Maryland) |
| ABSTRACT | Provided are methods of preparing an enriched population of T cells having antigenic specificity for a target antigen. The method may comprise isolating T cells from a tumor sample of a patient; selecting the isolated T cells which have a gene expression profile; and separating the selected T cells from the unselected cells. The separated selected T cells provide an enriched population of T cells having antigenic specificity for the target antigen. Methods of isolating a T cell receptor (TCR), preparing a population of cells that express a TCR, isolated TCRs, isolated populations of cells, pharmaceutical compositions, and methods of treating or preventing a condition in a mammal are also provided. |
| FILED | Friday, March 19, 2021 |
| APPL NO | 17/912315 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 15/1072 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) C12Q 1/6881 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230138328 | Yeo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eugene Yeo (La Jolla, California); Kristopher W. Brannan (Missouri City, Texas); Ryan Marina (Boston, Massachusetts); Isaac A. Chaim (San Diego, California); Daniel A. Lorenz (San Diego, California) |
| ABSTRACT | Provided are methods for using chimeric proteins to produce RNA modifications that can be detected by sequencing methods, including methods detecting relative translation rates of various mRNAs. Also provided herein are compositions comprising chimeric proteins, wherein the chimeric proteins comprise a RNA editing protein and a ribosomal protein. |
| FILED | Friday, March 12, 2021 |
| APPL NO | 17/910967 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1062 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230138388 | Padala et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sai Muralidhar Padala (Atlanta, Georgia); Eric Leo Sarin (Atlanta, Georgia) |
| ABSTRACT | The disclosure relates to a device that is configured to be implanted on the native leaflet of a heart valve to increase its length and/or thickness and thereby to improve the valve function and reduce regurgitation. The device may include a leaflet section. The leaflet section may include a central member. The central member may include a first portion, a second portion that opposes the first portion, and a base portion disposed between the first portion and the second portion. The first section may extend from the first portion and the second section may extend from the second portion. The device may include one or more engaging members extending from the central member at an angle with respect to the first section and the second section. The second section may be larger than the first section. The leaflet section may define a three-dimensional region or a bulge. |
| FILED | Tuesday, December 27, 2022 |
| APPL NO | 18/089127 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/246 (20130101) A61F 2/2463 (20130101) Original (OR) Class A61F 2/2466 (20130101) A61F 2220/0016 (20130101) A61F 2250/0098 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230138393 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Temple University-Of The Commonwealth System of Higher Education (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rongsheng E. Wang (Wynnewood, Pennsylvania); Md Shafiqul Islam (Philadelphia, Pennsylvania); Zhigang Lyu (Philadelphia, Pennsylvania); Yue Zhao (Philadelphia, Pennsylvania); Zakey Yusuf Buuh (Philadelphia, Pennsylvania) |
| ABSTRACT | This invention provides compositions comprising linked amino acid sequences, pharmaceutical compositions comprising linked amino acid sequences, and methods of making thereof. This invention also provides methods of delivering said compositions to subjects and methods of treating various disorders and diseases using the said compositions. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/904229 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/54 (20170801) A61K 47/542 (20170801) A61K 47/545 (20170801) Peptides C07K 1/1077 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230138484 | SACKSTEIN |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert SACKSTEIN (SUDBURY, Massachusetts) |
| ABSTRACT | Methods of treatment are provided herein, including administration of a population cells modified to enforce expression of an E-selectin and/or an L-selectin ligand, the modified cell population having a cell viability of at least 70% after a treatment to enforce such expression. |
| FILED | Thursday, November 10, 2022 |
| APPL NO | 18/054364 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/14 (20130101) A61K 35/28 (20130101) A61K 35/30 (20130101) Original (OR) Class A61K 35/32 (20130101) A61K 35/33 (20130101) A61K 35/34 (20130101) A61K 35/35 (20130101) A61K 35/37 (20130101) A61K 35/42 (20130101) A61K 35/407 (20130101) A61K 2035/124 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230138519 | Hu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ye Hu (Scottsdale, Arizona); Dali Sun (Tempe, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| INVENTOR(S) | Ye Hu (Scottsdale, Arizona); Dali Sun (Tempe, Arizona) |
| ABSTRACT | A mobile phone-based dark field microscope (MDFM) apparatus suitable for quantifying nanoparticle signals is provided. The MDFM apparatus includes an electrically operated light source, a dark-field condenser, a slide housing configured to receive an analytical slide, and an adapter housing configured to receive an objective lens and receive a portable electronic communication device. The slide housing positions the analytical slide between the objective lens and the dark-field condenser. The adapter housing registers the objective lens with a camera lens of the portable electronic communication device. A method for performing a biological quantitative study using the dark-field microscope apparatus is further provided. |
| FILED | Wednesday, December 21, 2022 |
| APPL NO | 18/069572 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/51 (20130101) G01N 33/587 (20130101) G01N 2201/0221 (20130101) Optical Elements, Systems, or Apparatus G02B 21/0008 (20130101) Original (OR) Class G02B 21/10 (20130101) G02B 21/025 (20130101) G02B 21/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230138663 | HODGETTS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio); THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin HODGETTS (Boston, Massachusetts); Chien-Liang Glenn LIN (Columbus, Ohio) |
| ABSTRACT | Disclosed are compounds that activate excitatory amino acid transporter 2 (EAAT2), as well as methods of using these compounds to treat or preventing diseases, disorders, and conditions associated with glutamate excitotoxicity. |
| FILED | Tuesday, October 04, 2022 |
| APPL NO | 17/959654 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/22 (20180101) A61P 25/24 (20180101) A61P 25/28 (20180101) Heterocyclic Compounds C07D 237/14 (20130101) C07D 401/04 (20130101) C07D 401/14 (20130101) Original (OR) Class C07D 413/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230138764 | Truong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | University of Southern California (Los Angeles, California) |
| INVENTOR(S) | Thai Truong (Los Angeles, California); Kevin Keomanee-Dizon (Los Angeles, California); Scott E. Fraser (Los Angeles, California) |
| ABSTRACT | Systems and methods are provided for increasing photon collection during imaging with a light-sheet fluorescence microscope. In one example, one or more adaptive optical elements may be positioned in a detection light path between a detection objective and an imaging sensor. A depth of field of the detection objective is adjusted as a function of a thickness of an excitation light-sheet used to illuminate a sample during imaging. As a result, the detection objective captures more fluorescence photons generated by light-sheet excitation. |
| FILED | Friday, March 12, 2021 |
| APPL NO | 17/910305 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6458 (20130101) Original (OR) Class Optical Elements, Systems, or Apparatus G02B 21/0032 (20130101) G02B 21/0076 (20130101) G02B 21/248 (20130101) G02B 21/367 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230138788 | GE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ying GE (Madison, Wisconsin); Song JIN (Madison, Wisconsin); Kyle BROWN (Madison, Wisconsin); Kevin BUCK (Madison, Wisconsin) |
| ABSTRACT | Exosomes are a small type of extracellular vesicles containing nucleic acids, lipids, and proteins that are implicated in tumorigenesis, metastasis, and cardiac regeneration, and therefore serve as potentially useful biomarkers from fluids or as vehicles for drug delivery. Global bottom-up mass spectrometry-based proteomics has been previously used to profile exosome cargo for diagnostic purposes. However, the current protocols for MS analysis of extracellular vesicles and exosome proteomics are challenging due to labor-intensive sample preparation, including lengthy digestion times and removal of MS incompatible reagents, and the need for high sensitivity. To address these challenges, the present invention provides a novel, high-throughput strategy for extracellular vesicle analysis and exosome proteomics using a photo-cleavable, anionic surfactant, preferably 4-hexylphenylazosulfonate (Azo). These photo-cleavable, anionic surfactants are able to facilitate high-throughput digestion with minimal sample cleanup for quantitative and highly reproducible analysis. |
| FILED | Tuesday, November 01, 2022 |
| APPL NO | 17/978793 |
| CURRENT CPC | Detergent Compositions; Use of Single Substances as Detergents; Soap or Soap-making; Resin Soaps; Recovery of Glycerol C11D 1/143 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/33 (20130101) G01N 33/52 (20130101) G01N 33/92 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230138861 | Johnson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Michael Austin Johnson (Sacramento, California); Jason Adams (Sacramento, California); Jean-Pierre Delplanque (Davis, California); Justin Koos (Sacramento, California); Gregory Rehm (Davis, California) |
| ABSTRACT | Resuscitation and ventilation monitoring devices are provided. A device includes an inlet in fluid communication with airflows exchanged with lungs of a patient and an airflow meter for measuring characteristics of the airflows. A user may provide a controller with patient information, e.g., height, weight, gender, or age, via a measurement selector, enabling the controller to determine acceptable ranges of measured airflow characteristics. The device may determine a current mode of ventilation and associated ventilator settings based on the measured airflow characteristics. The device may also identify and filter out artifacts present in the ventilation signal, and determine whether a respiratory failure phenotype is present in the ventilation. If the current mode of ventilation and associated ventilator settings fall outside an acceptable range, the ventilation is classified as off-target and the controller may cause a sensory alarm to alert the user. The device may suggest a corrective action based on the type of off-target ventilation detected. The device may also continuously analyze ventilation to determine changes in lung compliance over time and to identify pathological changes over time. The device may work within a network of devices and user interfaces via wired or wireless communication, and is not restricted to or dependent on the type of ventilatory device with which a patient is being supported. |
| FILED | Monday, August 29, 2022 |
| APPL NO | 17/898182 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0022 (20130101) A61B 5/742 (20130101) A61B 5/7203 (20130101) A61B 5/7264 (20130101) A61B 5/7282 (20130101) A61B 5/7405 (20130101) Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 31/00 (20130101) Original (OR) Class A61H 2201/5023 (20130101) A61H 2201/5087 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230138910 | RAY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Anandasankar RAY (Riverside, California); Joel KOWALEWSKI (La Quinta, California) |
| ABSTRACT | Provided herein are screening methods for identifying compounds for use as repellents, e.g., as alternatives to DEET, and as pesticides. Further provided are one or more compounds identified using the screening methods described herein, and compositions containing such compounds. |
| FILED | Friday, January 29, 2021 |
| APPL NO | 17/795854 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 25/02 (20130101) Original (OR) Class Biocidal, Pest Repellant, Pest Attractant or Plant Growth Regulatory Activity of Chemical Compounds or Preparations A01P 17/00 (20210801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230138927 | Mitchell et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Medical College of Wisconsin, Inc. (Milwaukee, Wisconsin) |
| ASSIGNEE(S) | The Medical College of Wisconsin, Inc. (Milwaukee, Wisconsin) |
| INVENTOR(S) | Michael Mitchell (Elm Grove, Wisconsin); Aoy Tomita Mitchell (Elm Grove, Wisconsin) |
| ABSTRACT | This invention relates to methods and compositions for assessing an amount of total cell-free DNA, such as from a subject having a pro-inflammatory response, such as a pro-inflammatory response associated with an infection, such as a COVID-19 infection. This invention also relates to compositions and methods for treating subjects having or suspected of having a pro-inflammatory response, such as a pro-inflammatory response associated with an infection, such as a COVID-19 infection. In embodiments, there is a risk of an inappropriate or detrimental pro-inflammatory response, such as in a subject with a COVID-19 infection. The methods and composition provided herein can be used to determine severity and risk of complications in a subject. The methods and composition provided herein can also be used to assess the effectiveness of a therapy in a subject, such as a COVID-19 subject. |
| FILED | Thursday, October 06, 2022 |
| APPL NO | 17/960904 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230139101 | Seelig et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Georg Seelig (Seattle, Washington); Richard Muscat (London, United Kingdom); Alexander B. Rosenberg (Seattle, Washington) |
| ABSTRACT | Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens. |
| FILED | Monday, July 25, 2022 |
| APPL NO | 17/814712 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6855 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230139443 | Guziewicz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karina E. Guziewicz (Broomall, Pennsylvania); Artur V. Cideciyan (Lafayette Hill, Pennsylvania); William A. Beltran (Wynnewood, Pennsylvania); Samuel G. Jacobson (Penn Valley, Pennsylvania); Gustavo D. Aguirre (Media, Pennsylvania) |
| ABSTRACT | Methods for treating bestrophinopathies are provided herein. The method includes, administering to an eye of the subject a dose of a recombinant adeno-associated virus (rAAV) vector comprising a nucleic acid sequence encoding a human BEST1 protein, wherein the subject has at least one mutant BEST1 allele. Also provided are methods for evaluating treatments for retinal degeneration. |
| FILED | Sunday, February 28, 2021 |
| APPL NO | 17/904899 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/12 (20130101) A61B 3/14 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) Original (OR) Class A61K 48/0058 (20130101) A61K 48/0075 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2750/14143 (20130101) C12N 2750/14145 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230139474 | Mali et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Prashant Mali (La Jolla, California); Dhruva Katrekar (La Jolla, California) |
| ABSTRACT | Aspects of the disclosure relate to a gene therapy approach for diseases, disorders, or conditions caused by mutation in the stop codon utilizing modified tRNA. At least 10-15% of all genetic diseases, including muscular dystrophy (e.g. Duchene muscular dystrophy), some cancers, beta thalassemia, Hurler syndrome, and cystic fibrosis, fall into this category. Not to be bound by theory, it is believed that this approach is safer than CRISPR approaches due to minimal off-target effects and the lack of genome level changes. |
| FILED | Thursday, August 25, 2022 |
| APPL NO | 17/822338 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/78 (20130101) C12N 15/115 (20130101) Original (OR) Class Enzymes C12Y 305/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230139506 | Gigoux et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MEMORIAL SLOAN KETTERING CANCER CENTER (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mathieu André-Jérôme Gigoux (New York, New York); Jedd D. Wolchok (New York, New York); Taha Merghoub (Jersey City, New Jersey) |
| ABSTRACT | In some aspects, the present invention provides heteroclitic CALRMUT peptides designed and selected to elicit an immune response to CALRMUT in subjects with JAK2 mutant-negative myeloproliferative neoplasms, nucleic acid molecules encoding such peptides, compositions comprising such peptides or nucleic acid molecules, and various associated compositions and methods. |
| FILED | Wednesday, March 17, 2021 |
| APPL NO | 17/912461 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/127 (20130101) A61K 9/1273 (20130101) A61K 9/5123 (20130101) A61K 38/00 (20130101) A61K 38/08 (20130101) A61K 39/0011 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230139561 | BAR-ZION et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institure of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Avinoam D. BAR-ZION (Pasadena, California); Atousa NOURMAHNAD (Pasadena, California); David MARESCA (Pasadena, California); Mikhail SHAPIRO (Pasadena, California) |
| ABSTRACT | The system and process of therapeutic and effective cavitation by using ultrasound to collapse gas vesicles as well as cavitate the bubbles produced from the collapsed gas vesicles. Therapeutic effect includes, but is not limited to lysing cells by cavitation. The cells expressing the gas vesicles can optionally be used as delivery cells to preform tasks such as transporting the gas vesicles into deep tissue areas, releasing compounds at the cavitation site, and more. The gas vesicles can optionally be modified to facilitate getting the bubbles near the cavitation targets by functionalizing the gas vesicles. |
| FILED | Friday, July 29, 2022 |
| APPL NO | 17/816373 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 7/00 (20130101) Original (OR) Class A61N 2007/0004 (20130101) A61N 2007/0039 (20130101) A61N 2007/0052 (20130101) A61N 2007/0082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230139588 | Hinrichs et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Christian S. Hinrichs (Bethesda, Maryland); Steven A. Rosenberg (Potomac, Maryland) |
| ABSTRACT | Disclosed are methods of preparing an isolated population of human papillomavirus (HPV)-specific T cells comprise dividing an HPV-positive tumor sample into multiple fragments; separately culturing the multiple fragments; obtaining T cells from the cultured multiple fragments; testing the T cells for specific autologous HPV-positive tumor recognition; selecting the T cells that exhibit specific autologous HPV-positive tumor recognition; and expanding the number of selected T cells to produce a population of HPV-specific T cells for adoptive cell therapy. Related methods of treating or preventing cancer using the T cells are also disclosed. |
| FILED | Monday, June 13, 2022 |
| APPL NO | 17/838662 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 39/12 (20130101) Original (OR) Class A61K 2039/5158 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 5/0638 (20130101) C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230139619 | LING et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SOUTHWEST RESEARCH INSTITUTE (San Antonio, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jian LING (Spring Branch, Texas); Stephen T. WELLINGHOFF (San Antonio, Texas); Carlos MartÍn CANTÚ (San Antonio, Texas); Angelica FERNANDEZ (San Antonio, Texas) |
| ABSTRACT | Devices and methods suitable for cell separation. The devices herein include non-random voids interconnected through non-random pores and/or non-random solid geometrical structures optionally connected through solid non-random interconnecting elements. Such devices are preferably suitable for affinity-based cell isolation techniques which rely upon binding interactions. |
| FILED | Thursday, October 27, 2022 |
| APPL NO | 18/050095 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) Original (OR) Class B01L 2200/0652 (20130101) B01L 2300/0681 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230139680 | Liu |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | The Texas A and M University System (College Station, Texas) |
| INVENTOR(S) | Wenshe Liu (College Station, Texas) |
| ABSTRACT | Embodiments of the present disclosure pertain to methods of selecting cyclic peptides that bind to a target by transforming a phage display library with a plurality of nucleic acids into bacterial host cells, where the nucleic acids include phage coat protein genes with a combinatorial region that encodes at least one cysteine and at least one non-canonical amino acid. The transformation results in the production of phage particles with phage coat proteins where the cysteine and the non-canonical amino acid couple to one another to form a cyclic peptide library. Phage particles are then screened against the desired target to select bound cyclic peptides. Amino acid sequences of the selected cyclic peptides are then identified. Additional embodiments pertain to methods of constructing a phage display library that encodes the cyclic peptides. Further embodiments of the present disclosure pertain to the produced cyclic peptides, phage display libraries and phage particles. |
| FILED | Monday, May 20, 2019 |
| APPL NO | 17/606938 |
| CURRENT CPC | Peptides C07K 7/56 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1037 (20130101) C12N 15/1055 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230139684 | SEDIVY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Brown University (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John M. SEDIVY (Barrington, Rhode Island); Gerwald JOGL (Pawtucket, Rhode Island); Alexandra D'ORDINE (Lakeville, Massachusetts) |
| ABSTRACT | Disclosed is a method for preventing, delaying or reversing age-associated inflammation, by administering to a patient in need thereof a therapeutically effective amount of at least one LINE 1 (L-1) endonuclease inhibitor. |
| FILED | Monday, November 23, 2020 |
| APPL NO | 17/778369 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/17 (20130101) A61K 31/53 (20130101) A61K 31/64 (20130101) A61K 31/145 (20130101) A61K 31/166 (20130101) A61K 31/167 (20130101) A61K 31/198 (20130101) A61K 31/366 (20130101) A61K 31/381 (20130101) A61K 31/423 (20130101) A61K 31/445 (20130101) A61K 31/505 (20130101) A61K 31/635 (20130101) A61K 31/4035 (20130101) A61K 31/4192 (20130101) A61K 31/4741 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230139837 | GE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Ying GE (Madison, Wisconsin); Song JIN (Madison, Wisconsin); Tania GUARDADO ALVAREZ (Madison, Wisconsin); Kyle BROWN (Madison, Wisconsin) |
| ABSTRACT | The present invention provides photo-cleavable anionic surfactants, particularly 4-hexylphenylazosulfonate (Azo) and sodium 4-hexylphenylazosulfonate derivatives, which can be rapidly degraded upon UV irradiation, for top-down and bottom-up proteomics. These surfactants can effectively solubilize proteins and peptide fragments with performance comparable to sodium dodecyl sulfate (SDS) and are compatible with mass spectrometry analysis of the solubilized proteins and peptide fragments. Top-down proteomic studies using the present photo-cleavable anionic surfactants has allowed the detection of 100-fold more unique proteoforms as compared to controls and has enabled the solubilization of membrane proteins for comprehensive characterization of protein post-translational modifications. In addition, the present photo-cleavable anionic surfactants are also suitable for dissolving polypeptides in bottom-up proteomic experiments including extracellular matrix proteomics, and are suitable as a substitute for SDS in gel electrophoresis. |
| FILED | Tuesday, December 20, 2022 |
| APPL NO | 18/069005 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 309/15 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/68 (20130101) G01N 33/6842 (20130101) G01N 33/6848 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230139913 | Pasqualini et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Renata Pasqualini (New Brunswick, New Jersey); Wadih Arap (New Brunswick, New Jersey); Fernanda Iamassaki Staquicini (New Brunswick, New Jersey); Fortunato Ferrara (Santa Fe, New Mexico); Sara D'Angelo (Santa Fe, New Mexico); Andrew R.M. Bradbury (Santa Fe, New Mexico) |
| ABSTRACT | Isolated or recombinant EphA5 or GRP78 targeting antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer. A method of rapidly identifying antibodies or antibody fragments for the treatment of cancer using a combination of in vitro and in vivo methodologies is also provided. |
| FILED | Tuesday, October 18, 2022 |
| APPL NO | 18/047533 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/07 (20130101) A61K 39/3955 (20130101) A61K 39/39558 (20130101) A61K 47/6803 (20170801) A61K 47/6817 (20170801) A61K 47/6843 (20170801) A61K 47/6849 (20170801) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/18 (20130101) C07K 16/28 (20130101) C07K 16/30 (20130101) Original (OR) Class C07K 16/3023 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1037 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57423 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230139938 | KIARIS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTH CAROLINA (Columbia, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | HIPPOKRATIS KIARIS (Irmo, South Carolina); Ioulia Chatzistamou (Irmo, South Carolina); Asieh Naderi (Columbia, South Carolina); Bernardo Chavez (Columbia, South Carolina) |
| ABSTRACT | Methods for treating lung injury by administration of an anti-CCL8 antibody are disclosed. Also disclosed are methods for evaluating lung therapies by use of an animal model of the genus Peromyscus. |
| FILED | Thursday, July 21, 2022 |
| APPL NO | 17/870593 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) A61P 29/00 (20180101) Peptides C07K 16/24 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5088 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230140200 | STOCKWELL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brent R. STOCKWELL (New York, New York); Angie Huizhong FENG (New York, New York); Jenny JIN (New York, New York) |
| ABSTRACT | The present disclosure provides, inter alia, methods for identifying cells undergoing non-apoptotic cell death, e.g., ferroptosis, in a subject, using anti-TfR1 antibodies such as 3F3-FMA. Methods for treating or ameliorating the effects of a cancer in a subject, methods for enhancing the anti-tumor effect of radiation in a subject with cancer undergoing radiotherapy, and compositions and kits comprising anti-TfR1 antibodies disclosed herein are also provided. The present disclosure also provides methods for identifying a classifier that detects and classifies a cell death modality in a cell. The classifier constructed by such methods serves as an unbiased tool for identification of features that best distinguish various cell death modalities. Also provided are methods for detecting a cell death modality in a system such as e.g., a cancer patient receiving therapies. |
| FILED | Wednesday, August 10, 2022 |
| APPL NO | 17/818807 |
| CURRENT CPC | Peptides C07K 16/2881 (20130101) Original (OR) Class C07K 2317/21 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5091 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230140210 | Holinstat et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Holinstat (Ann Arbor, Michigan); Reheman Adili (Ypsilanti, Michigan); Andrew White (Ann Arbor, Michigan); Theodore R. Holman (Santa Cruz, California) |
| ABSTRACT | Disclosed herein are small molecule inhibitors of platelet function, and methods of using the small molecules to treat diseases, such as platelet hemostasis and thrombosis. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof: wherein the substituents are as described. |
| FILED | Wednesday, October 19, 2022 |
| APPL NO | 17/969519 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/02 (20180101) Heterocyclic Compounds C07D 249/12 (20130101) Original (OR) Class C07D 403/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230140413 | McLeod et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois); University of Leeds (Leeds, United Kingdom); The J. Craig Venter Institute (Rockville, Maryland); Institute For Systems Biology (Seattle, Washington); U.S. Government, as represented by The Secretary of The Army Medical Command (MEDCOM) (Fort Detrick, Maryland); The University of Strathclyde (Glasgow, United Kingdom) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rima McLeod (Chicago, Illinois); Martin McPhillie (Leeds, United Kingdom); Colin W.G. Fishwick (Leeds, United Kingdom); Hernan Alejandro Lorenzi (Rockville, Maryland); Kai Wang (Seattle, Washington); Taek-Kyun Kim (Seattle, Washington); Yong Zhou (Seattle, Washington); Leroy E. Hood (Seattle, Washington); Ying Zhou (Chicago, Illinois); Kamal El Bissati (Chicago, None); Mark Hickman (Silver Spring, Maryland); QiGui Li (Silver Spring, Maryland); Craig Roberts (Glasgow, United Kingdom) |
| ABSTRACT | Disclosed herein are novel compounds for treating apicomplexan parasite related disorders, methods for their use; cell line and non-human animal models of the dormant parasite phenotype and methods for their use in identifying new drugs to treat apicomplexan parasite related disorders, and biomarkers to identify disease due to the parasite and its response to treatment. |
| FILED | Thursday, June 02, 2022 |
| APPL NO | 17/831049 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 33/06 (20180101) Heterocyclic Compounds C07D 215/233 (20130101) Original (OR) Class C07D 401/12 (20130101) C07D 405/12 (20130101) C07D 471/04 (20130101) C07D 487/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230140435 | Prosser et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin L. Prosser (Philadelphia, Pennsylvania); Kenneth B. Margulies (Villanova, Pennsylvania); Alexey Bogush (Elkins Park, Pennsylvania) |
| ABSTRACT | A recombinant viral vector comprising an expression cassette which comprises a coding sequence for an shRNA inhibitor of vasohibin (VASH)-small vasohibin binding protein (SVBP) complex operably linked to regulatory sequences which direct expression thereof is provided. Further provided are compositions containing such viral vectors formulated for delivery to a human patient. Also provided are methods using these vectors and compositions for improving or stabilizing cardiac function. |
| FILED | Tuesday, March 16, 2021 |
| APPL NO | 17/906522 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/53 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/85 (20130101) C12N 15/86 (20130101) C12N 15/1137 (20130101) Original (OR) Class C12N 2310/122 (20130101) C12N 2310/531 (20130101) C12N 2310/533 (20130101) C12N 2320/31 (20130101) C12N 2750/14143 (20130101) C12N 2840/20 (20130101) Enzymes C12Y 603/02025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230140549 | WUSSOW et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CITY OF HOPE (Duarte, California) |
| ASSIGNEE(S) | CITY OF HOPE (Duarte, California) |
| INVENTOR(S) | Felix WUSSOW (Monrovia, California); Don J. DIAMOND (Glendora, California) |
| ABSTRACT | An expression system for expressing a herpesvirus glycoprotein complex including a vector inserted with two or more nucleic acid sequences that encode two or more subunits of a herpesvirus glycoprotein complex linked by one or more linking sequences such that the subunits are co-expressed simultaneously and self-processed to assemble into a glycoprotein complex. The expression system or the vector can be included in a vaccine composition. The vaccine composition can be used for preventing or treating herpesvirus infections. |
| FILED | Thursday, June 09, 2022 |
| APPL NO | 17/806157 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/245 (20130101) Original (OR) Class Peptides C07K 14/05 (20130101) C07K 14/045 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230140692 | Yang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Boston University (Boston, Massachusetts) |
| ASSIGNEE(S) | Trustees of Boston University (Boston, Massachusetts) |
| INVENTOR(S) | Chen Yang (Newton, Massachusetts); Ji-Xin Cheng (Newton, Massachusetts); Nan Zheng (Allston, Massachusetts); Yueming Li (Brighton, Massachusetts); Ying Jiang (Brighton, Massachusetts); Lu Lan (Allston, Massachusetts); Carolyn Marar (Brighton, Massachusetts) |
| ABSTRACT | A system for neuromodulation includes a split-ring resonator (SRR) comprising a resonance circuit, the SRR being implantable in a cranial target site and a source of microwave signals, wherein the microwave signals are deliverable wirelessly to couple with the SRR to produce a localized electrical field, wherein the localized electrical field inhibits one or more neurons at the cranial target site with submillimeter spatial precision. |
| FILED | Tuesday, December 27, 2022 |
| APPL NO | 18/089122 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 18/1815 (20130101) Original (OR) Class A61B 2018/183 (20130101) A61B 2018/1869 (20130101) Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 7/082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230140770 | Wiesner et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ulrich B. Wiesner (Ithaca, New York); Kai MA (Belle Mead, New Jersey); Carlie Mendoza (East Meadow, New York) |
| ABSTRACT | An aqueous synthesis methodology for the preparation of silica nanoparticles (SNPs), core-shell SNPs having, for example, a size of 2 to 15 nm and narrow size-dispersion with size control below 1 nm, i.e. at the level of a single atomic layer. Different types of dyes, including near infrared (NIR) emitters, can be covalently encapsulated within and brightness can be enhanced via addition of extra silica shells. The surface may be functionalized with polyethylene glycol (PEG) groups and, optionally, specific surface ligands. This aqueous synthesis methodology also enables synthesis of 2 to 15 nm sized fluorescent core and core-shell aluminosilicate nanoparticles (ASNPs) which may also be surface functionalized. Encapsulation efficiency and brightness of highly negatively charged NIR fluorophores is enhanced relative to the corresponding SNPs without aluminum. |
| FILED | Tuesday, June 28, 2022 |
| APPL NO | 17/852242 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0071 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/141 (20130101) A61K 9/5115 (20130101) A61K 9/5146 (20130101) A61K 9/5192 (20130101) A61K 49/0032 (20130101) A61K 49/0093 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20230132533 | Lazarus et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | U.S. Army DEVCOM, Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nathan S. Lazarus (Rockville, Maryland); Jorge A. Cardenas (Tucson, Arizona); Harvey Hing-Cheong Tsang (Baltimore, Maryland) |
| ABSTRACT | A method and apparatus for electroless plating of a conductive composite created using fused filament fabrication. The method comprises fused filament fabricating a three-dimensional object with conductive filament and non-conductive filament. The object is then plated with electroless plating, with the metal in the conductive filament forming nucleation sites. |
| FILED | Tuesday, November 02, 2021 |
| APPL NO | 17/517336 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 18/24 (20130101) C23C 18/31 (20130101) C23C 18/204 (20130101) C23C 18/1608 (20130101) C23C 18/1641 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230132620 | Monroe et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Monroe (Ellicott City, Maryland); Martin LICHTMAN (Philadelphia, Pennsylvania); Ismail Volkan INLEK (Cary, North Carolina); Clayton CROCKER (Hyattsville, Maryland); Ksenia SOSNOVA (Silver Spring, Maryland) |
| ABSTRACT | The disclosure describes aspects of using multiple species in trapped-ion nodes for quantum networking. In an aspect, a quantum networking node is described that includes multiple memory qubits, each memory qubit being based on a 171Yb+ atomic ion, and one or more communication qubits, each communication qubit being based on a 138Ba+ atomic ion. The memory and communication qubits are part of a lattice in an atomic ion trap. In another aspect, a quantum computing system having a modular optical architecture is described that includes multiple quantum networking nodes, each quantum networking node including multiple memory qubits (e.g., based on a 171Yb+ atomic ion) and one or more communication qubits (e.g., based on a 138Ba+ atomic ion). The memory and communication qubits are part of a lattice in an atomic ion trap. The system further includes a photonic entangler coupled to each of the multiple quantum networking nodes. |
| FILED | Friday, December 23, 2022 |
| APPL NO | 18/146180 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) Electric Digital Data Processing G06F 9/3877 (20130101) G06F 9/5027 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Original (OR) Class Electric Discharge Tubes or Discharge Lamps H01J 49/422 (20130101) Transmission H04B 10/70 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0858 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230132806 | Gorodetsky et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Alon A. Gorodetsky (Irvine, California); Atrouli Chatterjee (Irvine, California); Juana Alejandra Cerna Sanchez (Irvine, California) |
| ABSTRACT | The description of living biological cells comprising heterologously expressed reflectin biomolecules that can be used to dynamically tune the optical properties of the host cells, as well as of the methods of fabrication thereof, are provided. Methods of regulating optical properties, including local refractive indices, of such cells with external stimuli are also provided. |
| FILED | Monday, April 12, 2021 |
| APPL NO | 17/918108 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/85 (20130101) Original (OR) Class C12N 2800/107 (20130101) C12N 2830/002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230132854 | Thorson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jon S. Thorson (Lexington, Kentucky); Jurgen Rohr (Lexington, Kentucky); Markos Leggas (Lexington, Kentucky); Joseph M. Eckenrode (Lexington, Kentucky); Yinan Zhang (Nanjing, Jiangsu, China PRC); Yang Liu (Lexington, Kentucky); Jianjun Zhang (Lexington, Kentucky); Khaled Attia Shaaban Mahmoud (Lexington, Kentucky) |
| ABSTRACT | Compounds described herein are mithramycin (MTM) oxide (OX) derivatives. These compounds are useful for treatment of cancers and neuro-diseases. |
| FILED | Tuesday, October 11, 2022 |
| APPL NO | 17/963537 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 15/26 (20130101) C07H 15/244 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230132955 | Venn-Watson |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | EPITRACKER, INC. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephanie Venn-Watson (San Diego, California) |
| ABSTRACT | Administration of pentadecanoylcarnitine or pentadecanoic acid is provided for prevention, management or treatment of aggression, allergies, allergic rhinitis, Alzheimer's disease, anxiety and anxiety disorders, amyotrophic lateral sclerosis, arthritis, asthma, atherosclerosis, attention-deficit hyperactivity disorder, bipolar disorder, brain damage, cancer, cardiovascular disease, cholestatic pruritis, depression, chronic obstructive pulmonary disease (COPD), cocaine abuse, cough, dermatitis, depression, drug-seeking behavior, gastrointestinal disorders, facial erythema associated with rosacea, glaucoma, hepatic diseases, hyperactive bladder, hypersensitivity disorders, hypertension, impulsivity, inflammation, mental disorders and conditions, metabolic disorders, migraines, nasal and sinus congestion, nausea, neuropathic pain with and symptoms of multiple sclerosis, neurological and neuropsychiatric disorders, obesity, obsessive-compulsive disorders, opioid-induced respiratory depression, osteoarthritis, pain, Parkinson disease, pathological gambling, peptic ulcers, schizophrenia, sleep disorders, spinal cord injury, tardive dyskinesia, tics and behavioral problems with Tourette's syndrome; as well as for supporting appetite, cardiovascular health, hematologic health, memory, metabolic health, mood, prolonged REM sleep, renal health, sexuality, sociability and metabolic, hematological, renal, and weight loss. |
| FILED | Tuesday, August 02, 2022 |
| APPL NO | 17/816950 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/20 (20130101) A61K 31/23 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/00 (20180101) A61P 11/06 (20180101) A61P 13/12 (20180101) A61P 17/06 (20180101) A61P 25/16 (20180101) A61P 25/24 (20180101) A61P 37/06 (20180101) A61P 37/08 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230133088 | Fok et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Femtosense, Inc. (San Bruno, California) |
| ASSIGNEE(S) | Femtosense, Inc. (San Bruno, California) |
| INVENTOR(S) | Sam Brian Fok (San Leandro, California); Alexander Smith Neckar (Redwood City, California); Gabriel Vega (Kailua, Hawaii) |
| ABSTRACT | Methods and apparatus for multi-purpose neural network core and memory. The asynchronous/parallel nature of neural network tasks may allow a neural network IP core to dynamically switch between: a system memory (in whole or part), a neural network processor (in whole or part), and/or a hybrid of system memory and neural network processor. In one specific implementation, the multi-purpose neural network IP core has partitioned its sub-cores into a first set of neural network sub-cores, and a second set of memory sub-cores that operate as addressable memory space. Partitioning may be statically assigned at “compile-time”, dynamically assigned at “run-time”, or semi-statically assigned at “program-time” Any number of considerations may be used to partition the sub-cores; examples of such considerations may include, without limitation: thread priority, memory usage, historic usage, future usage, power consumption, performance, etc. |
| FILED | Tuesday, October 25, 2022 |
| APPL NO | 18/049453 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/063 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230133478 | Bryan |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ROLLS-ROYCE NORTH AMERICAN TECHNOLOGIES INC. (Indianapolis, Indiana) |
| ASSIGNEE(S) | ROLLS-ROYCE NORTH AMERICAN TECHNOLOGIES INC. (Indianapolis, Indiana) |
| INVENTOR(S) | William Barry Bryan (Indianapolis, Indiana) |
| ABSTRACT | A turbofan engine has a fan portion in fluid communication with a core stream and a bypass stream of air separated by splitters disposed both upstream and downstream of the fan portion. A blade splitter (shroud) on the fan partially spans the fan blade thus separating the core and bypass streams downstream while leaving a gap upstream for communication between the flows. The communication gap expands the operational range of the fan over fans without the communication gap. |
| FILED | Thursday, December 29, 2022 |
| APPL NO | 18/148059 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 11/02 (20130101) F01D 17/162 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/04 (20130101) Original (OR) Class Jet-propulsion Plants F02K 3/06 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2240/14 (20130101) F05D 2240/55 (20130101) F05D 2240/122 (20130101) F05D 2240/301 (20130101) F05D 2240/304 (20130101) F05D 2260/606 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230133481 | Piedra et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Analog Devices, Inc. (Wilmington, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Piedra (Somerville, Massachusetts); James G. Fiorenza (Carlisle, Massachusetts); Puneet Srivastava (Wilmington, Massachusetts); Andrew Proudman (Medford, Massachusetts); Kenneth Flanders (Reading, Massachusetts); Denis Michael Murphy (Concord, Massachusetts); Leslie P. Green (Framingham, Massachusetts); Peter R. Stubler (Andover, Massachusetts) |
| ABSTRACT | Gallium nitride-based monolithic microwave integrated circuits (MMICs) can comprise aluminum-based metals. Electrical contacts for gates, sources, and drains of transistors can include aluminum-containing metallic materials. Additionally, connectors, inductors, and interconnect devices can also comprise aluminum-based metals. The gallium-based MMICs can be manufactured in complementary metal oxide semiconductor (CMOS) facilities with equipment that produces silicon-based semiconductor devices. |
| FILED | Friday, December 30, 2022 |
| APPL NO | 18/148996 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/8252 (20130101) H01L 21/28575 (20130101) H01L 23/66 (20130101) Original (OR) Class H01L 23/481 (20130101) H01L 23/53214 (20130101) H01L 27/0605 (20130101) H01L 27/0629 (20130101) H01L 28/60 (20130101) H01L 29/205 (20130101) H01L 29/452 (20130101) H01L 29/2003 (20130101) H01L 29/7786 (20130101) H01L 29/66462 (20130101) H01L 2223/6616 (20130101) H01L 2223/6683 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230134452 | Saboo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | QUESTEK INNOVATIONS LLC (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Abhinav Saboo (Evanston, Illinois); Ricardo Komai (Evanston, Illinois); Dana Frankel (Evanston, Illinois); Marie Thomas (Evanston, Illinois); Greg Olson (Evanston, Illinois) |
| ABSTRACT | Exemplary alloys may comprise, by weight percentage, 13.25% to 14.75% chromium; 4.5% to 5.5% nickel; 0.11% to 0.17% carbon; 0.01% to 0.31% titanium; and the balance of weight percent comprising iron and incidental elements and impurities. Exemplary methods may include conducting additive manufacturing with an atomized alloy powder to generate a manufactured article, where the atomized alloy powder may comprise, by weight percentage, 13.25% to 14.75% chromium; 4.5% to 5.5% nickel; 0.11% to 0.17% carbon; 0.01% to 0.31% titanium; and the balance of weight percent comprising iron and incidental elements and impurities. |
| FILED | Monday, October 31, 2022 |
| APPL NO | 17/977622 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 2201/11 (20130101) B22F 2301/35 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) Alloys C22C 38/001 (20130101) C22C 38/002 (20130101) C22C 38/42 (20130101) C22C 38/44 (20130101) C22C 38/46 (20130101) C22C 38/48 (20130101) C22C 38/50 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230134588 | Lostrom et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Naval Information Warfare Center Pacific (San Diego, California) |
| ASSIGNEE(S) | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (San Diego, California) |
| INVENTOR(S) | Carl E. Lostrom (San Diego, California); Gregory A. Jaccard (San Diego, California) |
| ABSTRACT | A self-adjusting band that includes one or more banding segments, one or more buckling assemblies, a pair of one pin and two links for each buckle assembly, a rotary joint base for each pair of one pin and two links, and a high-load, low-deflection compression spring for each section of the buckle assembly. |
| FILED | Tuesday, November 02, 2021 |
| APPL NO | 17/516907 |
| CURRENT CPC | Vessels for Containing or Storing Compressed, Liquefied or Solidified Gases; Fixed-capacity Gas-holders; Filling Vessels With, or Discharging From Vessels, Compressed, Liquefied, or Solidified Gases F17C 13/002 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230135432 | Thayumanavan |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sankaran Thayumanavan (Amherst, Massachusetts) |
| ABSTRACT | The invention provides polymers and polymeric nanogels in which nucleic acid molecules can be stably entrapped or encapsulated and are controllably delivered and released upon degradation of the nano-structures in response to specific microenvironment triggers, and compositions and methods of preparation and use thereof. |
| FILED | Saturday, December 24, 2022 |
| APPL NO | 18/088544 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 31/713 (20130101) A61K 47/58 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 220/286 (20200201) C08F 220/385 (20200201) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/87 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230135534 | SCHLEGEL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | L3Harris Technologies, Inc. (Melbourne, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christian SCHLEGEL (Park City, Utah); David G. LANDON (Bountiful, Utah) |
| ABSTRACT | A multipoint relay (MPR) wireless network may include spaced apart nodes, with each node including wireless transceiver circuitry, beacon circuitry, and a controller coupled to the wireless transceiver circuitry and beacon circuitry. The controllers may be configured to operate the beacon circuitry to determine a respective link strength metric for each potential link between nodes, assign a set of nodes from among the plurality of nodes to function as gateway nodes and assign other individual nodes to communicate via respective gateway nodes based upon the respective link strength metrics to define the MPR network so that one-hop links have a strongest link strength metric, and operate the wireless transceiver circuitry for communications over the MPR network. |
| FILED | Tuesday, November 02, 2021 |
| APPL NO | 17/453229 |
| CURRENT CPC | Wireless Communication Networks H04W 24/08 (20130101) H04W 40/12 (20130101) Original (OR) Class H04W 84/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230135769 | BHATTACHARYA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Uttaran BHATTACHARYA (College Park, Maryland); Aniket BERA (Greenbelt, Maryland); Dinesh MANOCHA (Bethesda, Maryland); Abhishek BANERJEE (Mountain View, California); Pooja GUHAN (College Park, Maryland); Nicholas REWKOWSKI (Greenbelt, Maryland) |
| ABSTRACT | Systems and methods of the present invention for gesture generation include: receiving a sequence of one or more word embeddings, one or more attributes, a gesture generation machine learning model; providing the sequence of one or more word embeddings and the one or more attributes to the gesture generation machine learning model; and providing the second emotive gesture of the virtual agent from the gesture generation machine learning model. The gesture generation machine learning model is configured to: produce, via an encoder, an output based on the one or more word embeddings; generate one or more encoded features based on the output and the one or more attributes; and produce, via a decoder, a emotive gesture based on the one or more encoded features and the preceding emotive gesture. Other aspects, embodiments, and features are also claimed and described. |
| FILED | Monday, October 31, 2022 |
| APPL NO | 17/977808 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/017 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/0455 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230136068 | MATZDORF et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America as represented by the Secretary of the Navy (Patuxent River, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | CRAIG MATZDORF (Hollywood, Maryland); Megan Fretz (Germantown, Maryland); Joshua Walles (California, Maryland) |
| ABSTRACT | Process for treating metal such as aluminum and its alloys to prevent corrosion which comprises coating the metal with a chromium-free conversion composition containing effective amounts of metal fluorozirconates and carboxylic metal salts. |
| FILED | Wednesday, November 03, 2021 |
| APPL NO | 17/517715 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 22/05 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230136164 | SOTOUDEH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Intelligent Fiber Optic Systems, inc. (San Jose, California) |
| ASSIGNEE(S) | Intelligent Fiber Optic Systems, inc. (San Jose, California) |
| INVENTOR(S) | Vahid SOTOUDEH (Los Altos, California); Behzad MOSLEHI (Los Altos, California); Joshua KUEHN (Boulder Creek, California); Richard J. BLACK (Menlo Park, California) |
| ABSTRACT | A temperature correcting pressure gauge which has a diaphragm having at least one surface coupled to a source of pressure to be measured, the diaphragm first surface having a first FBG from a first optical fiber attached in an appropriately sensitive region of the diaphragm, a FBG from a second optical fiber attached to the opposite surface from the first FBG, the first and second FBGs reflecting or transmitting optical energy of decreasing or increasing wavelength, respectively, in response to an applied pressure. The first and second FBGs have nominal operating wavelength ranges that are adjacent to each other but are exclusive ranges and the FBGs also have closely matched pressure coefficients and temperature coefficients. |
| FILED | Thursday, November 04, 2021 |
| APPL NO | 17/518598 |
| CURRENT CPC | Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 11/3206 (20130101) Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/246 (20130101) Original (OR) Class G01L 1/2281 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230136247 | Yao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| INVENTOR(S) | Yu Yao (Chandler, Arizona); Jing Bai (Tempe, Arizona) |
| ABSTRACT | A circular polarization filter of a chiral metasurface structure is disclosed including a substrate having a nanograting pattern extending from the substrate, a dielectric layer formed directly on the nanograting pattern, and a plasmonic structure in direct contact with the dielectric layer, where the plasmonic structure may be oriented at a nonzero angle with respect to the nanograting pattern. An integrated polarization filter array is also disclosed including include a linear polarization filter, and a circular polarization filter. Methods of detecting full-stokes polarization using an integrated polarization filter array having both linear and circular polarization filters made from chiral metasurface structures is disclosed. Methods of using a Mueller matrix to evaluate polarization response of any optical device or system is also disclosed. |
| FILED | Friday, October 21, 2022 |
| APPL NO | 18/048553 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/447 (20130101) G01J 4/04 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/21 (20130101) Optical Elements, Systems, or Apparatus G02B 1/002 (20130101) G02B 5/008 (20130101) Original (OR) Class G02B 5/201 (20130101) G02B 5/3041 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230136726 | Chew |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Peter A. Chew (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter A. Chew (Albuquerque, New Mexico) |
| ABSTRACT | Disclosed is a flexible, scalable method for automatically distinguishing between the ‘mainstream’ and ‘fringe’ in any text dataset, such as unstructured social media data. The disclosed method allows analysts quickly to pinpoint text articulating fringe beliefs or theories, without prior knowledge of the nature of the fringe beliefs, and can be applied to text data in any language, provided the data can be represented electronically. The method works automatically and without any preconceived notions of what is important or what vocabulary is used in the context of certain beliefs. An analyst's attention is then quickly focused either on new conspiracy theories taking hold (potentially allowing decision-makers to act to interdict the ‘next QAnon insurrection’), or on well-founded beliefs that simply are not yet mainstream. Either way, analysts are empowered better to ‘connect the dots’ for a more complete understanding of the information environment. |
| FILED | Friday, October 29, 2021 |
| APPL NO | 17/514283 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/35 (20190101) Original (OR) Class G06F 40/284 (20200101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00469 (20130101) G06K 9/6219 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230136833 | Schuster et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lockheed Martin Corporation (Bethesda, Maryland) |
| ASSIGNEE(S) | Lockheed Martin Corporation (Bethesda, Maryland) |
| INVENTOR(S) | Daniel George Schuster (Bethlehem, Connecticut); Evan S. Tobin (Sandy Hook, Connecticut); David N. Schmaling (Southbury, Connecticut) |
| ABSTRACT | A rotor blade retention assembly includes a central hub, a rotor blade including an upper outer surface, a lower outer surface, a blade hole, and a proximal end coupled to the central hub, a strap member extending along a portion of the rotor blade such that a distal end receiving portion extends into the blade hole, and a retainer assembly disposed within the blade hole and coupled to the strap member. The retainer assembly includes an upper bushing and a lower bushing slidably disposed within the blade hole. The upper bushing includes a counterbored portion. The retainer assembly also includes an outboard blade pin disposed within the distal end receiving portion and includes a blade pin inner cavity. |
| FILED | Wednesday, November 03, 2021 |
| APPL NO | 17/518370 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 27/10 (20130101) B64C 27/35 (20130101) B64C 27/48 (20130101) Original (OR) Class B64C 2027/8272 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230137113 | Tassev |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vladimir Tassev (Beavercreek, Ohio) |
| ABSTRACT | A method of performing HVPE heteroepitaxy comprises exposing a substrate to a carrier gas, a first precursor gas, a Group II/III element, and ternary-forming gasses (V/VI group precursor), to form a heteroepitaxial growth of a binary, ternary, and/or quaternary compound on the substrate; wherein the carrier gas is H2, wherein the first precursor gas is HCl, the Group II/III element comprises at least one of Zn, Cd, Hg, Al, Ga, and In; and wherein the ternary-forming gasses comprise at least two or more of AsH3 (arsine), PH3 (phosphine), H2Se (hydrogen selenide), H2Te (hydrogen telluride), SbH3 (hydrogen antimonide, or antimony tri-hydride, or stibine), H2S (hydrogen sulfide), NH3 (ammonia), and HF (hydrogen fluoride); flowing the carrier gas over the Group II/III element; exposing the substrate to the ternary-forming gasses in a predetermined ratio of first ternary-forming gas to second ternary-forming gas (1tf:2tf ratio); and changing the 1tf:2tf ratio over time. |
| FILED | Monday, October 17, 2022 |
| APPL NO | 18/046943 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/024 (20130101) H01L 21/02387 (20130101) H01L 21/02538 (20130101) H01L 21/02551 (20130101) H01L 21/02568 (20130101) H01L 21/02658 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
20230139276 — NANOCOMPOSITE MATERIAL FOR ULTRAVIOLET CURABLE DIRECT WRITE SEMICONDUCTOR APPLICATIONS
| US 20230139276 | Armiento et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts); The University of Massachusetts (Lowell, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Craig A. Armiento (Acton, Massachusetts); Yuri Piro (Boston, Massachusetts); Andrew M. Luce (Marlborough, Massachusetts); Emily Lamport (Pelham, New Hampshire); Oshadha Ranasingha (Salem, New Hampshire); Christopher R. Areias (Lawrence, Massachusetts); Christopher N. Kuncho (Attleboro, Massachusetts); Alkim Akyurtlu (Arlington, Massachusetts); Edward D. Kingsley (Stow, Massachusetts) |
| ABSTRACT | A chip-embedded printed circuit board includes a cavity in a printed circuit board, a chip in the cavity of the printed circuit board, and a thixotropic dielectric filler in a gap in the cavity to seal the chip in the printed circuit board. |
| FILED | Monday, November 01, 2021 |
| APPL NO | 17/515870 |
| CURRENT CPC | Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/037 (20130101) C09D 11/101 (20130101) C09D 11/102 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/183 (20130101) Original (OR) Class H05K 3/30 (20130101) H05K 2201/0112 (20130101) H05K 2201/0137 (20130101) H05K 2201/0209 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230139429 | Vasilakis |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nikolaos Vasilakis (Somerville, Massachusetts) |
| ABSTRACT | A privilege metric application quantifies a privilege reduction for a subject software module MS. Target critical resources Mt accessible by the subject module are identified. Permissions P(MS, Mt) for the subject module to access each of the target critical resources as a result of the privilege reduction are determined. Default library permissions Pbase(MS, Mt) without the privilege reduction are determined. A metric regarding the vulnerability reduction of P(MS, Mt) with respect to Pbase(MS, Mt) is quantified. |
| FILED | Monday, October 31, 2022 |
| APPL NO | 18/051084 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/45 (20130101) Original (OR) Class G06F 2221/2141 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/0869 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230139516 | Yang |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CEDARS-SINAI MEDICAL CENTER (Los Angeles, California) |
| ASSIGNEE(S) | CEDARS-SINAI MEDICAL CENTER (Los Angeles, California) |
| INVENTOR(S) | Wei Yang (Studio City, California) |
| ABSTRACT | Described herein are treatments and patient selection methods for cancers such as prostate cancer, breast cancer, liver cancer, bladder cancer, and melanoma. The treatment involves administering a RIPK2 inhibitor to a subject. The patient selection involves selecting a patient who has increased copy numbers or expression of both RIPK2 and MYC. |
| FILED | Monday, March 29, 2021 |
| APPL NO | 17/913760 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/5025 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230139589 | Kurtz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (, None) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Logan Kurtz (Eagle River, Alaska); Nichole Kurtz (Eagle River, Alaska) |
| ABSTRACT | A trailer for moving pallets on and off cargo aircraft is disclosed. The trailer includes a deck having a top surface that defines a top plane. The top of the deck has at least one pair of spaced apart forklift clearance channels therein that are disposed below the top plane of the deck and extend inward from at least one of the sides of the deck. Methods for loading and unloading pallets on and off cargo aircraft are also disclosed. |
| FILED | Monday, May 09, 2022 |
| APPL NO | 17/739760 |
| CURRENT CPC | Ground or Aircraft-carrier-deck Installations Specially Adapted for Use in Connection With Aircraft; Designing, Manufacturing, Assembling, Cleaning, Maintaining or Repairing Aircraft, Not Otherwise Provided For; Handling, Transporting, Testing or Inspecting Aircraft Components, Not Otherwise Provided for B64F 1/322 (20200101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230139650 | Tassev |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vladimir Tassev (Beavercreek, Ohio) |
| ABSTRACT | A method of performing HVPE heteroepitaxy comprises exposing a substrate to a carrier gas, a first precursor gas, a Group II/III element, and ternary-forming gasses (V/VI group precursor), to form a heteroepitaxial growth of a binary, ternary, and/or quaternary compound on the substrate; wherein the carrier gas is H2, wherein the first precursor gas is HCl, the Group II/III element comprises at least one of Zn, Cd, Hg, Al, Ga, and In; and wherein the ternary-forming gasses comprise at least two or more of AsH3 (arsine), PH3 (phosphine), H2Se (hydrogen selenide), H2Te (hydrogen telluride), SbH3 (hydrogen antimonide, or antimony tri-hydride, or stibine), H2S (hydrogen sulfide), NH3 (ammonia), and HF (hydrogen fluoride); flowing the carrier gas over the Group II/III element; exposing the substrate to the ternary-forming gasses in a predetermined ratio of first ternary-forming gas to second ternary-forming gas (1tf:2tf ratio); and changing the 1tf:2tf ratio over time. |
| FILED | Monday, October 17, 2022 |
| APPL NO | 18/046944 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/024 (20130101) H01L 21/02387 (20130101) H01L 21/02538 (20130101) H01L 21/02551 (20130101) H01L 21/02568 (20130101) H01L 21/02658 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230139931 | Boydston et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Jackson Boydston (Middleton, Wisconsin); Evan Sherbrook (Cambridge, Massachusetts) |
| ABSTRACT | In embodiments, a method for additive manufacturing of a metal-incorporated resin object comprises illuminating a curable composition comprising prepolymers, a metal compound, a photoredox catalyst, a polymerization initiator, and optionally, a redox agent, with light having a first wavelength, wherein the metal of the metal compound is characterized by an initial oxidation state, and the illumination induces polymerization reactions between prepolymers to form a first cured region and induces redox reactions to change the initial oxidation state of the metal in the first cured region. The method further comprises inducing polymerization reactions between prepolymers to form a second cured region different from the first cured region without inducing redox reactions in the second cured region. Also provided are the curable compositions, the additive manufacturing systems for carrying out the methods, and the metal-incorporated resin objects. |
| FILED | Tuesday, March 16, 2021 |
| APPL NO | 17/906405 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/124 (20170801) Original (OR) Class B29C 64/277 (20170801) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2105/0002 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 70/10 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230140413 | McLeod et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of Chicago (Chicago, Illinois); University of Leeds (Leeds, United Kingdom); The J. Craig Venter Institute (Rockville, Maryland); Institute For Systems Biology (Seattle, Washington); U.S. Government, as represented by The Secretary of The Army Medical Command (MEDCOM) (Fort Detrick, Maryland); The University of Strathclyde (Glasgow, United Kingdom) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rima McLeod (Chicago, Illinois); Martin McPhillie (Leeds, United Kingdom); Colin W.G. Fishwick (Leeds, United Kingdom); Hernan Alejandro Lorenzi (Rockville, Maryland); Kai Wang (Seattle, Washington); Taek-Kyun Kim (Seattle, Washington); Yong Zhou (Seattle, Washington); Leroy E. Hood (Seattle, Washington); Ying Zhou (Chicago, Illinois); Kamal El Bissati (Chicago, None); Mark Hickman (Silver Spring, Maryland); QiGui Li (Silver Spring, Maryland); Craig Roberts (Glasgow, United Kingdom) |
| ABSTRACT | Disclosed herein are novel compounds for treating apicomplexan parasite related disorders, methods for their use; cell line and non-human animal models of the dormant parasite phenotype and methods for their use in identifying new drugs to treat apicomplexan parasite related disorders, and biomarkers to identify disease due to the parasite and its response to treatment. |
| FILED | Thursday, June 02, 2022 |
| APPL NO | 17/831049 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 33/06 (20180101) Heterocyclic Compounds C07D 215/233 (20130101) Original (OR) Class C07D 401/12 (20130101) C07D 405/12 (20130101) C07D 471/04 (20130101) C07D 487/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20230132824 | Labram |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Oregon State University (Corvallis, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John G Labram (London, United Kingdom) |
| ABSTRACT | A retinomorphic sensor is demonstrated employing organic semiconductors. The sensor produces an output voltage in response to changes in illumination, but zero output voltage under constant illumination. The device is stable for periods up to one hour, exhibits a decay constant tunable through choice of external resistor, with fastest response times below 10 μs. |
| FILED | Friday, October 28, 2022 |
| APPL NO | 17/975667 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0512 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
20230133174 — SYSTEMS, METHODS, AND MEDIA FOR MORE EFFICIENT PERIDYNAMIC MODELING OF BOUNDED DOMAINS
| US 20230133174 | Jafarzadeh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Siavash Jafarzadeh (Lincoln, Nebraska); Florin Bobaru (Lincoln, Nebraska); Adam Larios (Lincoln, Nebraska) |
| ABSTRACT | In accordance with some embodiments, systems, methods, and media for efficient peridynamic modeling with bounded domains are provided. In some embodiments, a method comprises: receiving a plurality of parameters associated with a non-local model that has a convolutional structure to be used for one or more simulations, wherein the plurality of parameters includes a shape of a domain Ω, a horizon size δ, and one or more boundary constraints; drawing a periodic box |
| FILED | Monday, August 08, 2022 |
| APPL NO | 17/883195 |
| CURRENT CPC | Electric Digital Data Processing G06F 17/141 (20130101) G06F 30/20 (20200101) Original (OR) Class G06F 2111/10 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230133292 | Wu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Huang Wu (Evanston, Illinois); James Fraser Stoddart (Evanston, Illinois) |
| ABSTRACT | Adducts, superstructures, and crystalline compositions prepared from a metal halide anion non-covalently bound to the outer surface of a macrocycle and methods for gold recovery are disclosed. |
| FILED | Monday, March 29, 2021 |
| APPL NO | 17/907507 |
| CURRENT CPC | Production and Refining of Metals; Pretreatment of Raw Materials C22B 3/10 (20130101) C22B 3/44 (20130101) C22B 7/007 (20130101) C22B 11/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230133705 | Swarts |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Central Michigan University (Mount Pleasant, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin M. Swarts (Mount Pleasant, Michigan) |
| ABSTRACT | Described herein are trehalose analogues. Also described herein are methods of making the trehalose analogues and uses of the analogues. For example, the disclosed trehalose analogues may be useful in the detection of bacteria. |
| FILED | Tuesday, December 20, 2022 |
| APPL NO | 18/068852 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 7/06 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/04 (20130101) C12Q 1/16 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/60 (20130101) G01N 33/582 (20130101) G01N 2333/35 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230133791 | Kasturi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ranjita Pai Kasturi (Atlanta, Georgia); Brendan D. Saltaformaggio (Atlanta, Georgia) |
| ABSTRACT | In a method for detecting an attack compromise window in a CMS website for which a temporal sequence of a plurality of snapshots of website backups have been stored, a temporally ordered set of spatial elements from each snapshot is constructed. Spatial metrics are computed for each individual snapshot’s elements. The collected spatial metrics are temporally correlated and queried against attack models to recover an attack timeline. Attack events in the attack timeline are labelled. A sequence of assigned attack labels is verified. The compromise window is extracted from the plurality of snapshots. |
| FILED | Thursday, March 04, 2021 |
| APPL NO | 17/801686 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/554 (20130101) Original (OR) Class G06F 2221/033 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230135357 | APREA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SOLCHROMA TECHNOLOGIES, INC. (Somerville, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew APREA (Somerville, Massachusetts); Samuel SHIAN (Somerville, Massachusetts); Roger DIEBOLD (Somerville, Massachusetts) |
| ABSTRACT | Methods of driving a display matrix and matrix waveforms for driving said display matrix between color states are provided. Additionally, reflective displays incorporating a waveform generator to generate a waveform to drive the display from a first color state to a second color state are also provided. The reflective displays can include a display matrix having a plurality of row electrodes and a plurality of column electrodes; a plurality of display elements with an actuator to modify a color of the display element upon actuation; a fixed voltage source; and a waveform generator for determining an amount of time to apply the fixed voltage to each display element to drive the display element from a first color state to a second color state. The reflective display can be based on moving colored inks into and out of the viewable area of each display element to control the color. |
| FILED | Tuesday, March 16, 2021 |
| APPL NO | 17/912330 |
| CURRENT CPC | Arrangements or Circuits for Control of Indicating Devices Using Static Means to Present Variable Information G09G 3/344 (20130101) Original (OR) Class G09G 3/2003 (20130101) G09G 3/3486 (20130101) G09G 3/3493 (20130101) G09G 3/3681 (20130101) G09G 3/3692 (20130101) G09G 2300/0443 (20130101) G09G 2300/0452 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230135826 | Smith, III et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amos B Smith, III (Merion Station, Pennsylvania); Kevin T O'Brien (Sicklerville, New Jersey); Jonathan W Nadraws (Philadelphia, Pennsylvania) |
| ABSTRACT | Organodifluorine synthons, in conjunction with three-component diastereoselective Anion Relay Chemistry (ARC), permit ready access to diverse difluoromethylene scaffolds. Initiated via [1,2]-addition of an organolithium reagent to a β-difluoromethylene silyl aldehyde, an alkoxide intermediate is formed, which is capable of undergoing a [1,4]-Brook rearrangement to generate a stabilized α-difluoromethylene carbanion, which upon electrophile capture, affords a three-component adduct. This three-component synthetic tactic represents an important one-pot divergent strategy for the construction of diverse organodifluorine containing compounds. |
| FILED | Tuesday, November 01, 2022 |
| APPL NO | 18/051549 |
| CURRENT CPC | Heterocyclic Compounds C07D 307/20 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/10 (20130101) C07F 7/081 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230135901 | XU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honda Motor Co., Ltd. (Tokyo, Japan); California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qingmin XU (Dublin, Ohio); Christopher J. BROOKS (Dublin, Ohio); Kaoru OMICHI (Tochigi, Japan); Ryan K. MCKENNEY (Upper Arlington, Ohio); Simon JONES (Whittier, California); Victoria DAVIS (Santa Clara, California); Stephen MUNOZ (Pasadena, California); Jeongmin KIM (Pasadena, California); Keith BILLINGS (Yorba Linda, California); Thomas MILLER, III (South Pasadena, California); Robert H. GRUBBS (South Pasadena, California); William WOLF (Pasadena, California); Nam Hawn CHOU (Dublin, Ohio) |
| ABSTRACT | The present disclosure relates to fluoride ion batteries and structures of metal based electrode materials for various fluoride ion batteries. The structures of the metal based electrode materials comprise one or more shells or interfaces, enabling the electrodes to operate at room temperature with a liquid electrolyte. |
| FILED | Wednesday, December 28, 2022 |
| APPL NO | 18/147417 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/38 (20130101) H01M 4/366 (20130101) H01M 4/381 (20130101) H01M 4/582 (20130101) H01M 10/05 (20130101) H01M 10/36 (20130101) H01M 10/0568 (20130101) H01M 10/0569 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230135999 | Magin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, A Body Corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chelsea Magin (Denver, Colorado); Cassandra Petrou (Denver, Colorado); Rukshika Shalani Hewawasam (Denver, Colorado) |
| ABSTRACT | The present invention relates in part to hybrid hydrogel scaffolds including a decellularized extracellular matrix (dECM) tissue, and a synthetic polymer. The dECM may include any suitable tissue including for example, lung tissue, heart tissue, heart-lung block tissue, skin tissue, liver tissue, pancreatic tissue, kidney tissue, and the like. |
| FILED | Friday, April 02, 2021 |
| APPL NO | 17/915201 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/14 (20130101) A61L 27/52 (20130101) Original (OR) Class A61L 27/3633 (20130101) A61L 27/3804 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230136435 | Zhu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yong Zhu (Raleigh, North Carolina); Alper Bozkurt (Raleigh, North Carolina); William D. Reynolds, Jr. (Raleigh, North Carolina); Shuang Wu (Raleigh, North Carolina); Tanner Panithan Songkakul (Raleigh, North Carolina) |
| ABSTRACT | Various examples are related to bioimpedance measurements. In one example, a wearable monitoring system includes electrodes and processing circuitry configured for bioimpedance sensing. The electrodes can include a current source electrode, a current sink electrode, and voltage measurement electrodes aligned between the current source and sink electrodes. The processing circuitry can sense bioimpedance based upon excitation current applied through the current source and sink electrodes and measured voltage obtained through the voltage measurement electrodes across a range of excitation frequencies. The electrodes can be conformal and stretchable. In another example, a method for bioimpedance sensing includes positioning a wearable monitoring system on a surface, applying excitation current through the current source and sink electrodes over a range of excitation frequencies; measuring voltage across the voltage measurement electrodes over the excitation frequencies; and determining the bioimpedance using the applied excitation current and the measured voltage over the excitation frequencies. |
| FILED | Monday, October 31, 2022 |
| APPL NO | 17/977596 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0015 (20130101) A61B 5/0531 (20130101) A61B 5/0537 (20130101) Original (OR) Class A61B 5/6801 (20130101) A61B 5/7225 (20130101) A61B 2562/164 (20130101) A61B 2562/0215 (20170801) A61B 2562/0219 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230136666 | Lee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chi Hwan Lee (West Lafayette, Indiana); Laurent Couetil (West Lafayette, Indiana); Tae Hoo Chang (Beavercreek, Ohio); Semih Akin (West Lafayette, Indiana); Martin Byung-Guk Jun (West Lafayette, Indiana) |
| ABSTRACT | Electronic textiles and methods of fabrication electronic textiles. Nanoparticles of a conductive material are sprayed along a conductive path into a fabric material so as to penetrate into the fabric. A layer of a second conductor material is coated over the nanoparticles along the conductive path. A layer of an insulator material is coated over the layer of the second conductor material so as to encapsulate the conductive path and form a trace. An electrode configured to contact a subject wearing the fabric material includes a layer of a third conductor material coated over the layer of the second conductor and electrically coupled with the conductive path. An electrical connector is secured to the fabric material and electrically coupled with the conductive path. The nanoparticles are sprayed onto the fabric material using a dual regime spray process implemented with a dual regime spray system. |
| FILED | Monday, August 29, 2022 |
| APPL NO | 17/823021 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/27 (20210101) A61B 2503/40 (20130101) A61B 2562/0215 (20170801) A61B 2562/0285 (20130101) Treating Textile Materials Using Liquids, Gases or Vapours D06B 11/0059 (20130101) Treatment, Not Provided for Elsewhere in Class D06, of Fibres, Threads, Yarns, Fabrics, Feathers or Fibrous Goods Made From Such Materials D06M 11/65 (20130101) D06M 11/83 (20130101) D06M 15/693 (20130101) D06M 23/08 (20130101) D06M 2101/06 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 3/28 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/038 (20130101) Original (OR) Class H05K 1/092 (20130101) H05K 3/14 (20130101) H05K 2201/10151 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230136941 | Brandizzi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Federica Brandizzi (Okemos, Michigan); Pengfei Cao (East Lansing, Michigan); Anqi Xing (Lansing, Michigan) |
| ABSTRACT | Described herein are modified isopropylmalate synthase nucleic acids and proteins, as well as methods, plants, plant cells, and seeds that include the modified isopropylmalate synthase. As shown herein, plants and seeds with such modified isopropylmalate synthase nucleic acids and proteins have increased biomass and/or increased amino acid content. |
| FILED | Wednesday, April 07, 2021 |
| APPL NO | 17/995697 |
| CURRENT CPC | New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 1/108 (20210101) Original (OR) Class A01H 1/121 (20210101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230137096 | Baer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric Baer (Cleveland Heights, Ohio); Andy Olah (Spencer, Ohio); Zhenpeng Li (Shaker Heights, Ohio); Michael Hore (Shaker Heights, Ohio); Cong Zhang (Cleveland, Ohio) |
| ABSTRACT | A security marking has a physically unclonable function (PUF) wherein the PUF includes a disordered multilayer photonic crystal structure having an electromagnetic transmission and/or reflection spectrum and/or spectra upon receipt of electromagnetic radiation within a photonic bandgap region of the structure that is unique to the structure. |
| FILED | Monday, June 06, 2022 |
| APPL NO | 17/832892 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 48/001 (20190201) Original (OR) Class B29C 48/08 (20190201) B29C 48/21 (20190201) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2007/008 (20130101) Books; Book Covers; Loose Leaves; Printed Matter Characterised by Identification or Security Features; Printed Matter of Special Format or Style Not Otherwise Provided For; Devices for Use Therewith and Not Otherwise Provided For; Movable-strip Writing or Reading Apparatus B42D 25/45 (20141001) B42D 25/378 (20141001) Optical Elements, Systems, or Apparatus G02B 1/04 (20130101) G02B 5/1814 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230137327 | MEADOWS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | XplorStem LLC (San Diego, California) |
| ASSIGNEE(S) | XplorStem LLC (San Diego, California) |
| INVENTOR(S) | Vicki MEADOWS (San Diego, California); Robert MEADOWS (San Diego, California); Erika BARNER (El Cajon, California) |
| ABSTRACT | This invention concerns a centrifugal device that houses adapters for commercial or scientific samples (or tubes containing such samples) and is manually operated. In preferred embodiments, the adapter is housed in a modern version of a spinning top that is powered by repetitive pumping motion using a helical rod and clutch mechanism. |
| FILED | Tuesday, March 09, 2021 |
| APPL NO | 17/910669 |
| CURRENT CPC | Centrifuges B04B 5/0414 (20130101) B04B 9/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230137595 | Rao |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Rajesh P.N. Rao (Seattle, Washington) |
| ABSTRACT | Restoring and/or augmenting neural function may be achieved in some examples by receiving signals associated with a first region of a nervous system, and generating a stimulation pattern based on the signals associated with the first region of the nervous system and a first artificial network. The stimulation pattern may be provided to a second region of the nervous system to induce a behavioral output. In some examples, a second artificial network may be used to train the first artificial network. The second artificial network may be configured to predict the behavioral output from the individual based on the stimulation provided by the first artificial network. Parameters of the first artificial network can be adjusted using the output of the second artificial network to optimize the output signals of the first artificial network to achieve restoration and/or augmentation goals. |
| FILED | Tuesday, November 01, 2022 |
| APPL NO | 17/978764 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/025 (20130101) A61N 1/36103 (20130101) Original (OR) Class A61N 1/36135 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 40/63 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230137975 | CHEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey); The Trustees of Dartmouth College (Hanover, New Hampshire) |
| ASSIGNEE(S) | The Trustees of Princeton University (Princeton, New Jersey); The Trustees of Dartmouth College (Hanover, New Hampshire) |
| INVENTOR(S) | Minjie CHEN (Princeton, New Jersey); Charles SULLIVAN (West Lebanon, New Hampshire); Youssef E. ELASSER (Latham, New York); Daniel ZHOU (Princeton, New Jersey); Jaeil BAEK (Princeton, New Jersey); Yenan CHEN (West Windsor, New Jersey) |
| ABSTRACT | According to various embodiments, a power converter circuit is disclosed. The power converter circuit includes at least two vertically stacked printed circuit boards (PCBs) comprising a top PCB and a bottom PCB. The power converter circuit further includes at least one multiphase coupled inductor placed between the top PCB and the bottom PCB. The top PCB is coupled to the bottom PCB via at least one conductive winding of the multiphase coupled inductor. The power converter circuit further includes at least one circuit module placed above the top PCB and at least one power source placed below the bottom PCB. The multiphase coupled inductor is configured to deliver current vertically from the bottom PCB to the top PCB. |
| FILED | Wednesday, April 14, 2021 |
| APPL NO | 17/918646 |
| CURRENT CPC | Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 27/06 (20130101) H01F 27/255 (20130101) H01F 27/306 (20130101) H01F 2027/065 (20130101) Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/14 (20130101) Original (OR) Class H02M 7/003 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/144 (20130101) H05K 1/181 (20130101) H05K 2201/042 (20130101) H05K 2201/1003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230139056 | Bhagi-Damodaran et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| INVENTOR(S) | Ambika Bhagi-Damodaran (Minneapolis, Minnesota); Sourav Chatterjee (Minneapolis, Minnesota) |
| ABSTRACT | Disclosed herein are reactions, methods, reagents and compositions that utilize a nonheme iron halogenase enzyme to prepare compounds. |
| FILED | Friday, October 28, 2022 |
| APPL NO | 17/976580 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0071 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/26 (20130101) Original (OR) Class C12P 11/00 (20130101) C12P 13/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230139093 | LI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | LING LI (Starkville, Mississippi); EVE SYRKIN WURTELE (AMES, Iowa) |
| ABSTRACT | Method of increasing protein content in a eukaryotic cell comprising an NF-YC4 gene comprising modifying the transcriptional repressor binding site; method of producing a plant with increased protein content comprising crossing and selecting for increased protein content; method of increasing resistance to a pathogen or a pest in a plant cell or plant comprising an NF-YC4 gene comprising modifying the transcriptional repressor binding site, alone or in further combination with expressing QQS in the plant cell or plant; method for producing a plant with increased resistance to a pathogen or a pest comprising crossing and selecting for increased resistance to the pathogen or the pest; a cell, collection of cells, tissue, organ, or organism, such as a plant, in which the NF-YC4 gene comprises a promoter comprising a transcriptional repressor binding site that has been modified so that the transcriptional repressor cannot prevent transcription of the NF-YC4; plants and hybrids thereof; and seeds. |
| FILED | Monday, November 21, 2022 |
| APPL NO | 18/057439 |
| CURRENT CPC | New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 1/02 (20130101) Peptides C07K 14/415 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8205 (20130101) C12N 15/8216 (20130101) C12N 15/8241 (20130101) C12N 15/8247 (20130101) C12N 15/8251 (20130101) Original (OR) Class C12N 15/8279 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230139101 | Seelig et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Georg Seelig (Seattle, Washington); Richard Muscat (London, United Kingdom); Alexander B. Rosenberg (Seattle, Washington) |
| ABSTRACT | Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens. |
| FILED | Monday, July 25, 2022 |
| APPL NO | 17/814712 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6855 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230139528 | Won et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | You-Yeon Won (West Lafayette, Indiana); Hyun Chang Kim (West Lafayette, Indiana) |
| ABSTRACT | Disclosed herein are fully synthetic polymer-based lung surfactant materials, for the first time, as next generation SRT. In vitro studies on these polymer lung surfactants show that the candidate materials effectively mimic the surface tension controlling properties of currently marketed natural lung surfactants. Further, the polymer lung surfactants have strong protein resistance, which makes this class of materials promising also for potential use in Acute Respiratory Distress Syndrome (ARDS) treatment. |
| FILED | Wednesday, November 09, 2022 |
| APPL NO | 18/054082 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/08 (20130101) A61K 9/0019 (20130101) A61K 9/0082 (20130101) A61K 9/107 (20130101) A61K 9/1075 (20130101) A61K 31/765 (20130101) Original (OR) Class A61K 47/34 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230139938 | KIARIS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF SOUTH CAROLINA (Columbia, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | HIPPOKRATIS KIARIS (Irmo, South Carolina); Ioulia Chatzistamou (Irmo, South Carolina); Asieh Naderi (Columbia, South Carolina); Bernardo Chavez (Columbia, South Carolina) |
| ABSTRACT | Methods for treating lung injury by administration of an anti-CCL8 antibody are disclosed. Also disclosed are methods for evaluating lung therapies by use of an animal model of the genus Peromyscus. |
| FILED | Thursday, July 21, 2022 |
| APPL NO | 17/870593 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) A61P 29/00 (20180101) Peptides C07K 16/24 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5088 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230140050 | Hubbert |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University Corporation for Atmospheric Research (Boulder, Colorado) |
| ASSIGNEE(S) | University Corporation for Atmospheric Research (Boulder, Colorado) |
| INVENTOR(S) | John Clark Hubbert (Fort Collins, Colorado) |
| ABSTRACT | A band filter (100, 200) for filtering a discrete time series signal (110) is provided. The band filter (100, 200) includes an input frequency shifter (120, 220) configured to frequency down shift the discrete time series signal (110, 210) to provide a frequency down shifted discrete time series signal (120a, 220a), a regression based zero frequency centered band filter (130, 230) communicatively coupled to the input frequency shifter (120, 220), the regression based zero frequency centered band filter (130, 230) being configured to filter the frequency down shifted discrete time series signal (120a, 220a) to provide a filtered and frequency down shifted discrete time series signal (130a, 230a), and an output frequency shifter (140, 240) communicatively coupled to the regression based zero frequency centered band filter (130, 230), the output frequency shifter (140, 240) being configured to frequency up shift the filtered and frequency down shifted discrete time series signal (130a, 230a). |
| FILED | Thursday, October 28, 2021 |
| APPL NO | 17/513153 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 27/148 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230140398 | Marshall et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rebecca Marshall (Eugene, Oregon); Carl Brozek (Eugene, Oregon) |
| ASSIGNEE(S) | University of Oregon (Eugene, Oregon) |
| INVENTOR(S) | Rebecca Marshall (Eugene, Oregon); Carl Brozek (Eugene, Oregon) |
| ABSTRACT | Disclosed herein are embodiments of products comprising 1,2,3-triazolate metal-organic frameworks, including particle, composition, thin film, and device embodiments. Particles made of the 1,2,3-triazolate metal-organic frameworks exhibit unique properties compared to bulk materials, such as reduced polydispersity, increased conductivity, and other properties. Also disclosed herein are embodiments of a method for making particles comprising the 1,2,3-triazolate metal-organic framework and other products comprising the same. |
| FILED | Tuesday, October 25, 2022 |
| APPL NO | 17/973101 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 15/025 (20130101) Original (OR) Class Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 11/085 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20230132546 | Zhu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cheng Zhu (Livermore, California); Eric B. Duoss (Dublin, California); Zhen Qi (Tracy, California); Tony W. Van Buuren (Livermore, California); Marcus A. Worsley (Hayward, California) |
| ABSTRACT | Freeform fabrication of architected porous zinc via 3D printing. Ink including zinc powders, solvents and binders is created with printability. At least one 3D model is created with microarchitectures. Extrusion-based direct-writing is used to manufacture free-standing 3D zinc structures. Post-processing conditions generate final architected porous zinc products. |
| FILED | Wednesday, November 03, 2021 |
| APPL NO | 17/453396 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 3/114 (20130101) B22F 10/18 (20210101) Original (OR) Class B22F 10/80 (20210101) B22F 2301/30 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 50/00 (20141201) B33Y 80/00 (20141201) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/134 (20130101) H01M 4/0402 (20130101) H01M 2004/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230133245 | Sevov et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christo Sevov (Columbus, Ohio); Blaise Truesdell (Columbus, Ohio) |
| ABSTRACT | Disclosed herein are modified polyvinyl chloride polymers and oligomers, and methods of making the same. The modified polymers can be obtained via electrochemical reduction of polyvinyl chloride polymers. In some instances the modified polyvinyl chloride polymer is a crosslinked polymer, and in some instances the modified polyvinyl chloride polymer is a block copolymer. Disclosed herein are methods for selectively introducing various functional groups into a polyvinyl chloride polymer. |
| FILED | Friday, September 02, 2022 |
| APPL NO | 17/902091 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 2/58 (20130101) C08F 8/00 (20130101) C08F 114/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230133440 | Runyan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell Federal Manufacturing & Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | Honeywell Federal Manufacturing & Technologies, LLC (Kansas City, Missouri) |
| INVENTOR(S) | Paul Ryan Runyan (Prairie Village, Kansas); Eric Eugene Cornwell (Lees Summit, Missouri) |
| ABSTRACT | A system and method for displaying augmented reality information for a real object. A transparent display displays the information for the real object within a field of view, such that the information and the real object are simultaneously viewable by a user. Data-gathering peripheral devices gather data of the field of view, including a camera gathering visual data for tracking the real object. An articulating arm moveably supports and facilitates repositioning the display and redirecting the data-gathering peripheral devices in a particular direction. A security interlock disables the data-gathering peripherals when the articulating arm is moved beyond a pre-established threshold, thereby preventing the data-gathering peripherals from gathering data of a real environment outside of a limit of the field of view as determined by the pre-established threshold. The security interlock may include an adjustable contact switch which adjustably defines the pre-established threshold in at least one direction. |
| FILED | Thursday, November 04, 2021 |
| APPL NO | 17/518890 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/536 (20170101) G06T 7/557 (20170101) G06T 19/006 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230134210 | Busenitz |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| INVENTOR(S) | Clark Andrew Busenitz (Mission, Kansas) |
| ABSTRACT | An article transport case comprising an outer shell including opposing sections, first and second pinscreen assemblies, and first and second securement mechanisms. The pinscreen assemblies each include a frame, a securement plate, and a number of pins. The first and second securement mechanisms are configured to be in a secured configuration to retain the first and second sections in a closed configuration and keep the securement plates in a secured position thereby restraining the pins against the article in an article conforming arrangement. The securement plates are in an unsecured position so that the pins are free to translate longitudinally when the securement mechanisms are in an unsecured configuration such that the pins are not restrained in the article conforming arrangement when the shell is open. |
| FILED | Friday, October 29, 2021 |
| APPL NO | 17/513970 |
| CURRENT CPC | Containers for Storage or Transport of Articles or Materials, e.g Bags, Barrels, Bottles, Boxes, Cans, Cartons, Crates, Drums, Jars, Tanks, Hoppers, Forwarding Containers; Accessories, Closures, or Fittings Therefor; Packaging Elements; Packages B65D 81/05 (20130101) Original (OR) Class B65D 2581/051 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230134479 | Visco et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PolyPlus Battery Company (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven J. Visco (Berkeley, California); Yevgeniy S. Nimon (Danville, California); Bruce D. Katz (Moraga, California) |
| ABSTRACT | Batteries, component structures and manufacturing methods, in particular including a glassy embedded battery electrode assembly having a composite material structure composed of interpenetrating material components including a porous electroactive network including a solid electroactive material, and a continuous glassy medium including a Li ion conducting sulfide glass, can achieve enhanced power output, reduced charging time and/or improved cycle life. |
| FILED | Monday, August 01, 2022 |
| APPL NO | 17/816592 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/364 (20130101) H01M 4/624 (20130101) Original (OR) Class H01M 2004/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230135067 | WOODS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason David WOODS (Boulder, Colorado); Eric KOZUBAL (Superior, Colorado) |
| ABSTRACT | Integrated systems comprising both i) heat and mass exchange systems and ii) electrolysis stacks are disclosed, together with related methods of use. The disclosed systems cool and/or dehumidify air using two streams of salt solutions as liquid desiccants. |
| FILED | Wednesday, December 21, 2022 |
| APPL NO | 18/085950 |
| CURRENT CPC | Air-conditioning; Air-humidification; Ventilation; Use of Air Currents for Screening F24F 3/1417 (20130101) Original (OR) Class F24F 13/30 (20130101) F24F 2003/1435 (20130101) F24F 2003/1458 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230135458 | MUKHERJEE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Saptarshi MUKHERJEE (Milpitas, California); Tammy CHANG (San Ramon, California); Joseph W. TRINGE (Walnut Creek, California) |
| ABSTRACT | The present disclosure relates to a volumetric additive manufacturing system for forming a structure from a volume of resin using microwave energy. The system makes use of an electronic controller and at least one beam forming algorithm accessible by the electronic controller for generating information relating to an amplitude and a time delay for forming a microwave signal, where the microwave signal will be used in irradiating a build volume, and where the build volume is formed by the volume of resin. A microwave signal generating subsystem is included which is responsive to the information generated by the beam forming algorithm, and which generates a microwave signal using the amplitude and the time delay determined by the beam forming algorithm. An antenna is used to receive the microwave signal and project the microwave signal as a microwave beam, in accordance with the amplitude and time delay, into the build volume to form the structure. |
| FILED | Wednesday, November 03, 2021 |
| APPL NO | 17/518115 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/129 (20170801) Original (OR) Class B29C 64/241 (20170801) B29C 64/245 (20170801) B29C 64/264 (20170801) B29C 64/393 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 50/02 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230135792 | Mcculloch |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | TRIAD National Security, LLC. (Los Alamos, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Quinn Mcculloch (Los Alamos, New Mexico) |
| ABSTRACT | A system includes a light source, a transparent container, a detector, and a processor. The light source emits light. Liquid flows from one end of the transparent container to another end of the transparent container. The liquid comprises a first and a component. One or more droplets containing the second component are formed within the transparent container as the liquid flows from the one end to the another end of the transparent container. The detector measures light intensities from the transparent container being illuminated. The one or more droplets cast shadows on the detector. A light intensity associated with a portion of the liquid that includes the one or more droplets is different from a second light intensity associated with another portion of the liquid that does not include the one or more droplets. The processor processes the measured light intensities to determine phase entrainment metrics associated with the liquid. |
| FILED | Monday, October 31, 2022 |
| APPL NO | 17/977233 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/06 (20130101) Original (OR) Class G01N 2015/0693 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230135901 | XU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honda Motor Co., Ltd. (Tokyo, Japan); California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qingmin XU (Dublin, Ohio); Christopher J. BROOKS (Dublin, Ohio); Kaoru OMICHI (Tochigi, Japan); Ryan K. MCKENNEY (Upper Arlington, Ohio); Simon JONES (Whittier, California); Victoria DAVIS (Santa Clara, California); Stephen MUNOZ (Pasadena, California); Jeongmin KIM (Pasadena, California); Keith BILLINGS (Yorba Linda, California); Thomas MILLER, III (South Pasadena, California); Robert H. GRUBBS (South Pasadena, California); William WOLF (Pasadena, California); Nam Hawn CHOU (Dublin, Ohio) |
| ABSTRACT | The present disclosure relates to fluoride ion batteries and structures of metal based electrode materials for various fluoride ion batteries. The structures of the metal based electrode materials comprise one or more shells or interfaces, enabling the electrodes to operate at room temperature with a liquid electrolyte. |
| FILED | Wednesday, December 28, 2022 |
| APPL NO | 18/147417 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/38 (20130101) H01M 4/366 (20130101) H01M 4/381 (20130101) H01M 4/582 (20130101) H01M 10/05 (20130101) H01M 10/36 (20130101) H01M 10/0568 (20130101) H01M 10/0569 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230136397 | Cave et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Twelve Benefit Corporation (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Etosha R. Cave (Berkeley, California); Sichao Ma (Dublin, California); Qun Zeng (Oakland, California); Sara Hunegnaw (Oakland, California); Kendra P. Kuhl (Oakland, California); George Leonard (Oakland, California); Ashley D. Mishra (Danville, California); Ajay R. Kashi (Berkeley, California) |
| ABSTRACT | Disclosed are membrane electrode assemblies having a cathode layer comprising a carbon oxide reduction catalyst that promotes reduction of a carbon oxide; an anode layer comprising a catalyst that promotes oxidation of a water; a polymer electrolyte membrane (PEM) layer disposed between, and in contact with, the cathode layer and the anode layer; and a salt having a concentration of at least about 10 uM in at least a portion of the MEA. |
| FILED | Thursday, December 22, 2022 |
| APPL NO | 18/145702 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 3/03 (20210101) C25B 3/07 (20210101) C25B 3/25 (20210101) Original (OR) Class C25B 3/26 (20210101) C25B 9/23 (20210101) C25B 13/08 (20130101) C25B 15/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230136736 | Visco et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PolyPlus Battery Company (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven J. Visco (Berkeley, California); Vitaliy Nimon (San Francisco, California); Valentina Loginova (Walnut Creek, California); Yevgeniy S. Nimon (Danville, California); Bruce D. Katz (Moraga, California) |
| ABSTRACT | An intermediary solid electrolyte structure having a Li ion conducting solid electrolyte layer covered with a thin as-deposited lithium phosphorus nitride film. A surface protected solid electrolyte having a solid electrolyte layer having a first major surface that is covered by a composite protective film, the composite protective film having a lithium phosphorus material component and a phosphorus nitride material component. A physical vapor deposition target for the deposition of a composite protective film, the target having a compacted composite material target having a mosaic structure. Methods of making thin films. |
| FILED | Thursday, October 20, 2022 |
| APPL NO | 18/048400 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/0407 (20130101) H01M 4/0423 (20130101) H01M 4/628 (20130101) Original (OR) Class H01M 10/0562 (20130101) H01M 2300/0068 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230137786 | Reyes |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| INVENTOR(S) | Joseph Reyes (Gladstone, Missouri) |
| ABSTRACT | A mold extractor for separating a molded part from a mold portion following a molding process, and a method of using the same. The mold extractor includes a mold holder that removably couples to the mold portion, a retainer that abuts a portion of the molded part and that surrounds the mold holder such that a cavity is provided between the mold holder and the retainer, and an extraction rod engaged with the mold holder and the retainer and spanning the cavity between the mold holder and the retainer. The mold extractor is set up to reduce a distance between the mold holder and the retainer along the extraction rod such that the mold holder translates into the cavity and imparts a force on the mold portion sufficient to extract the mold portion from the molded part. |
| FILED | Wednesday, November 03, 2021 |
| APPL NO | 17/517877 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 37/0003 (20130101) B29C 43/50 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230138133 | Alahyari et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Abbas A. Alahyari (Glastonbury, Connecticut); Kimberly Rae Saviers (Glastonbury, Connecticut); Joseph Turney (Amston, Connecticut); Jagadeesh Kumar Tangudu (South Windsor, Connecticut) |
| ABSTRACT | Aircraft electric motors include a motor unit having a rotor and a stator. The stator includes a plurality of windings and cooling channels arranged to provide cooling thereto. A drive unit is configured to drive operation of the motor unit. A cooling system includes a working fluid arranged within a cooling fluid flow path, wherein the cooling fluid flow path includes a liquid cooling path configured to direct flow of the working fluid through, at least, the cooling channels of the motor unit and a vapor cooling path configured to direct flow of the working fluid through the drive unit and a separator arranged upstream of each of the liquid cooling path and the vapor cooling path and configured to direct a liquid portion of the working fluid into the liquid cooling path and configured to direct a vapor portion of the working fluid into the vapor cooling path. |
| FILED | Monday, November 01, 2021 |
| APPL NO | 17/515934 |
| CURRENT CPC | Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 27/24 (20130101) Original (OR) Class B64D 33/08 (20130101) Dynamo-electric Machines H02K 9/197 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230138178 | Cronce et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Michael Cronce (Berkeley, California); Jeffrey S. Cox (San Francisco, California); Jay D. Keasling (Berkeley, California) |
| ABSTRACT | The present invention provides for a genetically modified gut bacterial cell capable of producing an antiviral compound. The genetically modified gut bacterial cell can be introduced to a subject to colonize the gastrointestinal tract of the subject, produce the antiviral compound and increase resistance to a virus infection. |
| FILED | Friday, June 24, 2022 |
| APPL NO | 17/849327 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/74 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/12 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/74 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230138417 | Fang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Utah Research Foundation (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhigang Zak Fang (Salt Lake City, Utah); Yang Xia (Salt Lake City, Utah); Pei Sun (Salt Lake City, Utah); Ying Zhang (Salt Lake City, Utah) |
| ABSTRACT | A method (100) for producing a particulate titanium alloy product can include preparing (110) a composite particulate oxide mixture with TiO2 powder and at least one alloying element powder. The composite particulate oxide mixture can be co-reduced (120) using a metallic reducing agent under a hydrogen atmosphere at a reduction temperature for a reduction time sufficient to produce a hydrogenated titanium alloy product. The hydrogenated titanium alloy product can then be heat treated (130) under a hydrogen atmosphere and a heat treating temperature to reduce pore size and specific surface area to form a heat treated hydrogenated titanium product. The heat treated hydrogenated titanium product can be deoxygenated (140) to reduce residual oxygen to less than 0.2 wt % to form a deoxygenated hydrogenated titanium product as a particulate. The deoxygenated hydrogenated titanium product can optionally be dehydrogenated (150) to form the titanium alloy product as a particulate. |
| FILED | Monday, February 01, 2021 |
| APPL NO | 17/912305 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 9/04 (20130101) B22F 9/20 (20130101) B22F 2201/013 (20130101) B22F 2301/205 (20130101) B22F 2998/10 (20130101) B22F 2999/00 (20130101) Production and Refining of Metals; Pretreatment of Raw Materials C22B 34/1263 (20130101) Alloys C22C 1/0458 (20130101) C22C 14/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230138829 | Taha et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNM Rainforest Innovations (Albuquerque, New Mexico); National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico); Transpo Industries, Inc. (New Rochelle, New York) |
| ASSIGNEE(S) | UNM Rainforest Innovations (Albuquerque, New Mexico); National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico); Transpo Industries, Inc. (New Rochelle, New York) |
| INVENTOR(S) | Mahmoud Reda Taha (Albuquerque, New Mexico); Michael S. Stenko (Albuquerque, New Mexico); John Stormont (Albuquerque, New Mexico); Edward N. Matteo (Albuquerque, New Mexico); Moneeb Genedy (Albuquerque, New Mexico); Thomas Dewers (Albuquerque, New Mexico) |
| ABSTRACT | A method and sealant to seal microcracks as small as 50 μm by causing methyl methacrylate combined with one or more nanoparticles to flow into the microcrack to be sealed. |
| FILED | Tuesday, December 27, 2022 |
| APPL NO | 18/089470 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 8/428 (20130101) Original (OR) Class Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 33/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230139143 | Brambilla |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | FastCAP Systems Corporation (Wakefield, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicolo Brambilla (Brookline, Massachusetts) |
| ABSTRACT | Disclosed herein is a method for using a high temperature rechargeable energy storage device comprising (a) obtaining an HTRESD; and (b) at least one of (1) cycling the HTRESD by alternatively charging and discharging the HTRESD at least twice over a duration of 20 hours and (2) maintaining a voltage across the HTRESD for 20 hours, such that the HTRESD exhibits a peak power density between 0.005 W/liter and 75 kW/liter after 20 hours when operated at an ambient temperature in an operating temperature range comprising between about −40° C. and about 210° C. |
| FILED | Friday, October 28, 2022 |
| APPL NO | 17/976080 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/24 (20130101) H01G 11/36 (20130101) H01G 11/52 (20130101) H01G 11/56 (20130101) Original (OR) Class H01G 11/60 (20130101) H01G 11/62 (20130101) H01G 11/64 (20130101) H01G 11/68 (20130101) H01G 11/70 (20130101) H01G 11/78 (20130101) H01G 11/80 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/13 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230139377 | Harris et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VARTEGA INC. (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jordan Gray Harris (Arvada, Colorado); Kylie Marie Van Aken (Edgewater, Colorado); Sean Paul Kline (Littleton, Colorado); Andrew Timothy Maxey (Arvada, Colorado); Sean Louis Hankins (Golden, Colorado) |
| ABSTRACT | Recycled carbon fibers are processed by rotational tumbling in a mixture with binder material to prepare fiber-containing particles having a dual-tapered shape and general alignment of fibers with a longitudinal direction of the particles. Bulk products including such fiber-containing particles are compounded with polymer and pelletized to prepare fiber-reinforced composite pellets, which are useful for applications such as injection molding to prepare molded products of carbon fiber-reinforced composite material with recycled carbon fibers. |
| FILED | Thursday, February 17, 2022 |
| APPL NO | 17/674089 |
| CURRENT CPC | Preparation or Pretreatment of the Material to be Shaped; Making Granules or Preforms; Recovery of Plastics or Other Constituents of Waste Material Containing Plastics B29B 9/06 (20130101) B29B 9/14 (20130101) Original (OR) Class Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 45/0001 (20130101) B29C 45/0005 (20130101) B29C 2045/001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230139913 | Pasqualini et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Renata Pasqualini (New Brunswick, New Jersey); Wadih Arap (New Brunswick, New Jersey); Fernanda Iamassaki Staquicini (New Brunswick, New Jersey); Fortunato Ferrara (Santa Fe, New Mexico); Sara D'Angelo (Santa Fe, New Mexico); Andrew R.M. Bradbury (Santa Fe, New Mexico) |
| ABSTRACT | Isolated or recombinant EphA5 or GRP78 targeting antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer. A method of rapidly identifying antibodies or antibody fragments for the treatment of cancer using a combination of in vitro and in vivo methodologies is also provided. |
| FILED | Tuesday, October 18, 2022 |
| APPL NO | 18/047533 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/07 (20130101) A61K 39/3955 (20130101) A61K 39/39558 (20130101) A61K 47/6803 (20170801) A61K 47/6817 (20170801) A61K 47/6843 (20170801) A61K 47/6849 (20170801) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/18 (20130101) C07K 16/28 (20130101) C07K 16/30 (20130101) Original (OR) Class C07K 16/3023 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1037 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57423 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230139949 | Scime et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Luke R. Scime (Knoxville, Tennessee); Vincent C. Paquit (Knoxville, Tennessee); Desarae J. Goldsby (Knoxville, Tennessee); William H. Halsey (Knoxville, Tennessee); Chase B. Joslin (Knoxville, Tennessee); Michael D. Richardson (Knoxville, Tennessee); Derek C. Rose (Knoxville, Tennessee); Derek H. Siddel (Knoxville, Tennessee) |
| ABSTRACT | Detection and classification of anomalies for powder bed metal additive manufacturing. Anomalies, such as recoater blade impacts, binder deposition issues, spatter generation, and some porosities, are surface-visible at each layer of the building process. A multi-scaled parallel dynamic segmentation convolutional neural network architecture provides additive manufacturing machine and imaging system agnostic pixel-wise semantic segmentation of layer-wise powder bed image data. Learned knowledge is easily transferrable between different additive manufacturing machines. The anomaly detection can be conducted in real-time and provides accurate and generalizable results. |
| FILED | Monday, October 03, 2022 |
| APPL NO | 17/958499 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/80 (20210101) Original (OR) Class Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/153 (20170801) B29C 64/386 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 50/02 (20141201) Image Data Processing or Generation, in General G06T 3/4046 (20130101) G06T 3/4053 (20130101) G06T 7/0004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230140365 | SU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wencong SU (Troy, Michigan); Yi Lu MURPHEY (Ann Arbor, Michigan); Mengqi WANG (Troy, Michigan); Can HUANG (Fremont, California); Ruben GLATT (Livermore, California) |
| ABSTRACT | A system and method for automatically determining a topology configuration for a power converter. The system is configured to perform a method that includes the steps of: receiving, at a workstation, one or more design attributes from a user; automatically selecting a topology through use of a machine learning (ML) technique that takes, as input, the received design attribute(s); determining one or more design parameter values for one or more design parameters to be used along with the automatically selected topology; and providing the automatically selected topology and determined design parameter value(s) to the user. |
| FILED | Tuesday, November 01, 2022 |
| APPL NO | 17/978935 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/27 (20200101) Original (OR) Class G06F 30/392 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20230133022 | Hochberg et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BROWN UNIVERSITY (Providence, Rhode Island); THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Leigh Hochberg (East Greenwich, Rhode Island); John D. Simeral (Providence, Rhode Island); Tyler Singer-Clark (Falmouth, Massachusetts); Ronnie Gross (Portsmouth, Rhode Island); Thomas Hosman (Providence, Rhode Island); Anastasia Kapitonava (Boston, Massachusetts) |
| ABSTRACT | Instances of a single brain computer interface (BCI) system can be implemented on multiple devices. An active instance can control the associated device. The instances can each communicate with a neural decoding system that can receive neural signals from a user, process the neural signals, and output a command based on the processed neural signals. A device running the active instance of can be in communication with the neural decoding system to receive a command. The device can include a display, a non-transitory memory storing instructions, and a processor to execute the instructions to: run an instance of a control program; and execute the task based on the command. |
| FILED | Tuesday, November 01, 2022 |
| APPL NO | 17/978271 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/015 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230136997 | Frank et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Children's Medical Center Corporation (Boston, Massachusetts); The Brigham and Woman's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Children's Medical Center Corporation (Boston, Massachusetts); The Brigham and Woman's Hospital, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Markus H. Frank (Cambridge, Massachusetts); Natasha Y. Frank (Cambridge, Massachusetts) |
| ABSTRACT | The present invention is directed to methods and compositions for treating Glioblastoma multiforme (GBM). The risk of developing therapy resistant GBM may be assessed by detecting the presence of ABCB5 in the GBM cells. Therapeutic interventions utilizing an ABCB5 blockade to sensitize the GBM cells to therapeutic agents such as temozolomide are provided. |
| FILED | Wednesday, April 14, 2021 |
| APPL NO | 17/918479 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/495 (20130101) A61K 39/3955 (20130101) Original (OR) Class A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) A61P 35/00 (20180101) Peptides C07K 16/28 (20130101) C07K 16/40 (20130101) C07K 16/3053 (20130101) C07K 2317/31 (20130101) C07K 2317/622 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230137504 | Gilotra et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland); UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, Maryland); THE UNITED STATES GOVERMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mohit Gilotra (Ellicott City, Maryland); Rayan Khalid Alabsi (Rockville, Maryland); Tejasvi Subramanya (Oxnard, California) |
| ABSTRACT | A reverse shoulder prosthesis system is provided. The system can include a the convex surface of the glenosphere and the concave surface of the humeral socket. The convex surface, a humeral socket can have a concave surface, and a cup is positioned between cup can be moveable relative to the glenosphere and to the humeral socket. |
| FILED | Thursday, January 21, 2021 |
| APPL NO | 17/794215 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/4014 (20130101) A61F 2/4059 (20130101) A61F 2/4081 (20130101) Original (OR) Class A61F 2002/30367 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230138188 | Ben-Ari et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alon Y. Ben-Ari (Carmichael, California); Sigal Ben-Ari (Carmichael, California) |
| ABSTRACT | Computing systems, computing devices, computer-implemented methods, and computer-program products are provided for a secure computer-based pre-operative assessment. In some embodiments, a computing system can authenticate a user identifier via an authentication service. Based on authenticating the user identifier, the computing system can cause output of a graphical user interface configured to elicit one or more responses associated with a user condition. The computing system also can receive the one or more responses via the graphical user interface, and can associate the one or more responses with the user identifier. The computing system can generate, based on the one or more responses, at least one of a visual representation or an aural representation indicative of the user condition, and can cause output of at least one of the visual representation or the aural representation. |
| FILED | Thursday, November 03, 2022 |
| APPL NO | 17/980414 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/31 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) Original (OR) Class G16H 20/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20230132588 | Letzt et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Healthcare Technologies and Methods, LLC (Fredericksburg, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alan Letzt (Purcellville, Virginia); Stephanie Letzt (Purcellville, Virginia) |
| ABSTRACT | A system, device, and wireless computer technology-implemented method for providing hearing healthcare education and communication for a patient, his/her communication partner, and a hearing care provider. The system provides the patient at least one educational and experiential module and a method for assessing the patient's comprehension of the module's lessons. The system further provides the patient with a method to select personal hearing aid and communication goals; a method to evaluate his/her progress on achieving each personal goal; and a method to report his/her hearing experiences. The system further provides a method to compare data reported by the patient to personalized thresholds. When one or more of the patient's reports do not meet the thresholds, the system sends automated alerts to the hearing care provider to encourage prompt remedial action and sends automated reminders to the patient to improve the patient's ability to achieve his/her personal goals. |
| FILED | Wednesday, December 28, 2022 |
| APPL NO | 18/090263 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/123 (20130101) A61B 5/4833 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 7/00 (20130101) G09B 19/00 (20130101) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/00 (20180101) G16H 40/67 (20180101) Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 25/70 (20130101) H04R 2225/55 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230132602 | PLACE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | miRecule, Inc. (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert PLACE (Gaithersburg, Maryland); Anthony SALEH (Gaithersburg, Maryland); Tishan WILLIAMS (Gaithersburg, Maryland) |
| ABSTRACT | Disclosed herein are engineered oligonucleotides for selective inhibition of polypeptide expression and activity. Also disclosed herein are methods of selectively inhibiting polypeptide expression and activity contacting an engineered oligonucleotide with a polynucleotide encoding the polypeptide. |
| FILED | Friday, April 02, 2021 |
| APPL NO | 17/915215 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/549 (20170801) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/33 (20130101) C12N 2310/141 (20130101) C12N 2310/316 (20130101) C12N 2310/321 (20130101) C12N 2310/322 (20130101) C12N 2310/351 (20130101) C12N 2310/531 (20130101) C12N 2310/3521 (20130101) C12N 2320/31 (20130101) C12N 2320/32 (20130101) C12N 2320/35 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230132955 | Venn-Watson |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | EPITRACKER, INC. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephanie Venn-Watson (San Diego, California) |
| ABSTRACT | Administration of pentadecanoylcarnitine or pentadecanoic acid is provided for prevention, management or treatment of aggression, allergies, allergic rhinitis, Alzheimer's disease, anxiety and anxiety disorders, amyotrophic lateral sclerosis, arthritis, asthma, atherosclerosis, attention-deficit hyperactivity disorder, bipolar disorder, brain damage, cancer, cardiovascular disease, cholestatic pruritis, depression, chronic obstructive pulmonary disease (COPD), cocaine abuse, cough, dermatitis, depression, drug-seeking behavior, gastrointestinal disorders, facial erythema associated with rosacea, glaucoma, hepatic diseases, hyperactive bladder, hypersensitivity disorders, hypertension, impulsivity, inflammation, mental disorders and conditions, metabolic disorders, migraines, nasal and sinus congestion, nausea, neuropathic pain with and symptoms of multiple sclerosis, neurological and neuropsychiatric disorders, obesity, obsessive-compulsive disorders, opioid-induced respiratory depression, osteoarthritis, pain, Parkinson disease, pathological gambling, peptic ulcers, schizophrenia, sleep disorders, spinal cord injury, tardive dyskinesia, tics and behavioral problems with Tourette's syndrome; as well as for supporting appetite, cardiovascular health, hematologic health, memory, metabolic health, mood, prolonged REM sleep, renal health, sexuality, sociability and metabolic, hematological, renal, and weight loss. |
| FILED | Tuesday, August 02, 2022 |
| APPL NO | 17/816950 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/20 (20130101) A61K 31/23 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/00 (20180101) A61P 11/06 (20180101) A61P 13/12 (20180101) A61P 17/06 (20180101) A61P 25/16 (20180101) A61P 25/24 (20180101) A61P 37/06 (20180101) A61P 37/08 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230136164 | SOTOUDEH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Intelligent Fiber Optic Systems, inc. (San Jose, California) |
| ASSIGNEE(S) | Intelligent Fiber Optic Systems, inc. (San Jose, California) |
| INVENTOR(S) | Vahid SOTOUDEH (Los Altos, California); Behzad MOSLEHI (Los Altos, California); Joshua KUEHN (Boulder Creek, California); Richard J. BLACK (Menlo Park, California) |
| ABSTRACT | A temperature correcting pressure gauge which has a diaphragm having at least one surface coupled to a source of pressure to be measured, the diaphragm first surface having a first FBG from a first optical fiber attached in an appropriately sensitive region of the diaphragm, a FBG from a second optical fiber attached to the opposite surface from the first FBG, the first and second FBGs reflecting or transmitting optical energy of decreasing or increasing wavelength, respectively, in response to an applied pressure. The first and second FBGs have nominal operating wavelength ranges that are adjacent to each other but are exclusive ranges and the FBGs also have closely matched pressure coefficients and temperature coefficients. |
| FILED | Thursday, November 04, 2021 |
| APPL NO | 17/518598 |
| CURRENT CPC | Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 11/3206 (20130101) Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/246 (20130101) Original (OR) Class G01L 1/2281 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20230132688 | Yagoobi |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Worcester Polytechnic Institute (Worcester, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jamal S. Yagoobi (Hopkinton, Massachusetts) |
| ABSTRACT | A combined electrohydrodynamic (EHD) and dielectrophoretic (DEP) cooling approach for a processor or similar electronics in a zero gravity environment is beneficial in space exploration. An EHD pumping mechanism is defined by an array of alternating, polarized electrodes surrounding a heat sink coupled to the processor for heat exchange, such as a thermally conductive layer or coating. The array may be circular, rectangular, or any suitable geometry, generally guided by a shape of the heat sink/processor. Cooling fluid is drawn or pumped towards the heat sink by EHD electrodes, and a dielectrophoretic (DEP) electrode disposed above the center of the heat sink extracts the generated vapor bubbles away from the heated surface with a diverging electrical field. One configuration calls for a radial arrangement of EHD electrodes drawing the cooling fluid towards a centrally located heat sink. |
| FILED | Thursday, October 27, 2022 |
| APPL NO | 17/975437 |
| CURRENT CPC | Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/0201 (20130101) H05K 7/2039 (20130101) H05K 7/20327 (20130101) Original (OR) Class H05K 2201/066 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230135901 | XU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honda Motor Co., Ltd. (Tokyo, Japan); California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qingmin XU (Dublin, Ohio); Christopher J. BROOKS (Dublin, Ohio); Kaoru OMICHI (Tochigi, Japan); Ryan K. MCKENNEY (Upper Arlington, Ohio); Simon JONES (Whittier, California); Victoria DAVIS (Santa Clara, California); Stephen MUNOZ (Pasadena, California); Jeongmin KIM (Pasadena, California); Keith BILLINGS (Yorba Linda, California); Thomas MILLER, III (South Pasadena, California); Robert H. GRUBBS (South Pasadena, California); William WOLF (Pasadena, California); Nam Hawn CHOU (Dublin, Ohio) |
| ABSTRACT | The present disclosure relates to fluoride ion batteries and structures of metal based electrode materials for various fluoride ion batteries. The structures of the metal based electrode materials comprise one or more shells or interfaces, enabling the electrodes to operate at room temperature with a liquid electrolyte. |
| FILED | Wednesday, December 28, 2022 |
| APPL NO | 18/147417 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/38 (20130101) H01M 4/366 (20130101) H01M 4/381 (20130101) H01M 4/582 (20130101) H01M 10/05 (20130101) H01M 10/36 (20130101) H01M 10/0568 (20130101) H01M 10/0569 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230136397 | Cave et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Twelve Benefit Corporation (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Etosha R. Cave (Berkeley, California); Sichao Ma (Dublin, California); Qun Zeng (Oakland, California); Sara Hunegnaw (Oakland, California); Kendra P. Kuhl (Oakland, California); George Leonard (Oakland, California); Ashley D. Mishra (Danville, California); Ajay R. Kashi (Berkeley, California) |
| ABSTRACT | Disclosed are membrane electrode assemblies having a cathode layer comprising a carbon oxide reduction catalyst that promotes reduction of a carbon oxide; an anode layer comprising a catalyst that promotes oxidation of a water; a polymer electrolyte membrane (PEM) layer disposed between, and in contact with, the cathode layer and the anode layer; and a salt having a concentration of at least about 10 uM in at least a portion of the MEA. |
| FILED | Thursday, December 22, 2022 |
| APPL NO | 18/145702 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 3/03 (20210101) C25B 3/07 (20210101) C25B 3/25 (20210101) Original (OR) Class C25B 3/26 (20210101) C25B 9/23 (20210101) C25B 13/08 (20130101) C25B 15/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20230132767 | Simonpietri et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Simonpietri Enterprises LLC (Kailua, Hawaii) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marie-Joelle Simonpietri (Kailua, Hawaii); Zachary Wadas (Kailua, Hawaii) |
| ABSTRACT | Methods and systems for processing construction and demolition (C&D) materials to produce a product gas stream and/or electricity are disclosed herein. In some embodiments, the method comprises pre-processing C&D materials to produce a C&D feed, and processing the C&D feed to produce syngas. The C&D feed can comprise untreated wood, treated wood, paper and cardboard, yard waste, plastic, rubber, and/or foam. Processing the C&D feed can comprise gasifying the C&D feed, steam, and oxygen in a gasifier at a temperature of no more than 950° C. and/or a pressure of no more than 200 psi to produce syngas. |
| FILED | Friday, October 28, 2022 |
| APPL NO | 18/050950 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 3/02 (20130101) Production of Producer Gas, Water-gas, Synthesis Gas From Solid Carbonaceous Material, or Mixtures Containing These Gases; Carburetting Air or Other Gases C10J 3/78 (20130101) Original (OR) Class C10J 2300/092 (20130101) C10J 2300/0946 (20130101) C10J 2300/1696 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230134943 | Atiyeh |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents for Oklahoma State University (Stillwater, Oklahoma) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hasan K. Atiyeh (Stillwater, Oklahoma) |
| ABSTRACT | Biocatalytic conversion systems and methods of producing and using same that have improved yields are disclosed. The systems and methods involve co-fermentation of sugars and gaseous substrates for alcohol, ketone, and/or organic acid production. The systems and methods may include biocatalytically converting at least one sugar substrate into at least one of alcohol, at least one ketone, and/or at least one organic acid. The systems and methods may further include biocatalytically converting gases that comprise CO2 and H2 to at least one alcohol and/or at least one organic acid, thereby adding extra revenue to biorefineries. |
| FILED | Tuesday, December 20, 2022 |
| APPL NO | 18/068681 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 21/12 (20130101) C12M 23/58 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 1/22 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/16 (20130101) C12P 7/28 (20130101) C12P 7/52 (20130101) C12P 7/54 (20130101) C12P 7/065 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 20230134943 | Atiyeh |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents for Oklahoma State University (Stillwater, Oklahoma) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hasan K. Atiyeh (Stillwater, Oklahoma) |
| ABSTRACT | Biocatalytic conversion systems and methods of producing and using same that have improved yields are disclosed. The systems and methods involve co-fermentation of sugars and gaseous substrates for alcohol, ketone, and/or organic acid production. The systems and methods may include biocatalytically converting at least one sugar substrate into at least one of alcohol, at least one ketone, and/or at least one organic acid. The systems and methods may further include biocatalytically converting gases that comprise CO2 and H2 to at least one alcohol and/or at least one organic acid, thereby adding extra revenue to biorefineries. |
| FILED | Tuesday, December 20, 2022 |
| APPL NO | 18/068681 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 21/12 (20130101) C12M 23/58 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 1/22 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/16 (20130101) C12P 7/28 (20130101) C12P 7/52 (20130101) C12P 7/54 (20130101) C12P 7/065 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230136925 | PU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ziyuan PU (Seattle, Washington); Ruimin KE (Seattle, Washington); Chenxi LIU (Seattle, Washington); Hao YANG (Seattle, Washington); Yinhai WANG (Seattle, Washington) |
| ABSTRACT | A mobile roadway sensing unit can include an image sensor that can sense image data, a network sensor that can acquire wireless signal data, and a weather sensor that can sense weather condition data. The mobile roadway sensing unit can include a processor and a memory. The memory can include instructions executable by the processor for causing the processor to acquire the sensor data including at least one of the image data, the wireless signal data, or the weather condition data from the weather sensor, wherein the sensor data represents one or more current conditions proximate the mobile roadway sensing unit. The processor can generate processed data based on the sensor data The processor can generate, based on the processed data, a notification corresponding to the one or more current conditions. The processor can provide the notification to one or more external electronic devices. |
| FILED | Friday, October 28, 2022 |
| APPL NO | 18/050930 |
| CURRENT CPC | Image or Video Recognition or Understanding G06V 20/54 (20220101) Traffic Control Systems G08G 1/04 (20130101) G08G 1/0116 (20130101) Original (OR) Class G08G 1/0967 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Environmental Protection Agency (EPA)
| US 20230132767 | Simonpietri et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Simonpietri Enterprises LLC (Kailua, Hawaii) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marie-Joelle Simonpietri (Kailua, Hawaii); Zachary Wadas (Kailua, Hawaii) |
| ABSTRACT | Methods and systems for processing construction and demolition (C&D) materials to produce a product gas stream and/or electricity are disclosed herein. In some embodiments, the method comprises pre-processing C&D materials to produce a C&D feed, and processing the C&D feed to produce syngas. The C&D feed can comprise untreated wood, treated wood, paper and cardboard, yard waste, plastic, rubber, and/or foam. Processing the C&D feed can comprise gasifying the C&D feed, steam, and oxygen in a gasifier at a temperature of no more than 950° C. and/or a pressure of no more than 200 psi to produce syngas. |
| FILED | Friday, October 28, 2022 |
| APPL NO | 18/050950 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 3/02 (20130101) Production of Producer Gas, Water-gas, Synthesis Gas From Solid Carbonaceous Material, or Mixtures Containing These Gases; Carburetting Air or Other Gases C10J 3/78 (20130101) Original (OR) Class C10J 2300/092 (20130101) C10J 2300/0946 (20130101) C10J 2300/1696 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230139291 | Thomson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James A. Thomson (Madison, Wisconsin); Srikumar Sengupta (Madison, Wisconsin) |
| ABSTRACT | Methods for derivation, culture, and maturation of small hepatic progenitor cells are described. |
| FILED | Tuesday, December 27, 2022 |
| APPL NO | 18/146998 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/407 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/067 (20130101) Original (OR) Class C12N 2500/30 (20130101) C12N 2501/11 (20130101) C12N 2501/33 (20130101) C12N 2501/39 (20130101) C12N 2501/40 (20130101) C12N 2502/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Central Intelligence Agency (CIA)
| US 20230135240 | Cody et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Censys, Inc. (Ann Arbor, Michigan) |
| ASSIGNEE(S) | Censys, Inc. (Ann Arbor, Michigan) |
| INVENTOR(S) | Jeff Cody (Huntertown, Indiana); David Adrian (Denver, Colorado); J. Alex Halderman (Ann Arbor, Michigan); Paul A. Parkanzky (Ann Arbor, Michigan) |
| ABSTRACT | Various embodiments of a scanning engine are described. In some embodiments, the scanning engine comprises discovery components associated with different Internet providers and/or protocol detection components associated with the different Internet providers. When a first discovery component associated with a first Internet provider does not receive a response from a port at an Internet address, then a second discovery component associated with a second Internet provider sends packets to that port at that Internet address to attempt to elicit a response. When a first protocol inspection component associated with a first Internet provider is not able to communicate with a port at an Internet address, then it provides information that can be obtained by a second protocol inspection component associated with a second Internet provider. That second protocol inspection component attempts to communicate with the port at the Internet address through the second Internet provider using various communication protocols. |
| FILED | Friday, October 28, 2022 |
| APPL NO | 18/050941 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 69/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20230133356 | Hager |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Vesper Marine Holdings, LLC (Portland, Maine) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark William Hager (Middleboro, Massachusetts) |
| ABSTRACT | One disclosed method involves encoding an acquired image of a fish filet into a first feature vector consumable by at least one predictive model, processing, with the at least one predictive model, the first feature vector to identify a type of fish from which the fish filet was cut, and causing at least one device to output an indication of the type of fish identified by the at least one predictive model. Another disclosed method involves associating first images of fish filets with metadata indicative of one or more types of fish from which the fish filets were cut, using the first images and the metadata to train at least one predictive model to categorize second images of fish filets into the one or more types of fish, and providing the at least one predictive model to at least one device so as to nable the at least one device to output an indication of the one or more types of fish based acquired images of fish filets. |
| FILED | Friday, March 12, 2021 |
| APPL NO | 17/910648 |
| CURRENT CPC | Electric Digital Data Processing G06F 18/24 (20230101) Original (OR) Class G06F 18/214 (20230101) Image or Video Recognition or Understanding G06V 10/17 (20220101) G06V 20/68 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
U.S. Agency for International Development (USAID)
| US 20230134571 | SOK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | International AIDS Vaccine Initiative (New York, New York); The Scripps Research Institute (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Devin SOK (New York, New York); Dennis R. BURTON (La Jolla, California); Joseph G. JARDINE (La Jolla, California) |
| ABSTRACT | The present disclosure relates to anti-HIV Env antibodies and their use in the treatment or prevention of HIV/AIDS. In one aspect, provided herein are enhanced engineered anti-HIV Env antibodies that were derived from the PGDM1400 parent antibody using directed-evolution and yeast display. In one aspect, provided herein are pharmaceutical compositions comprising the enhanced engineered anti-HIV Env antibodies disclosed herein. |
| FILED | Thursday, October 29, 2020 |
| APPL NO | 17/772561 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Peptides C07K 16/1045 (20130101) Original (OR) Class C07K 2317/31 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/565 (20130101) C07K 2317/567 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20230137047 | OLDS |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | EAGLE TECHNOLOGY, LLC (MELBOURNE, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | KEITH A. OLDS (Melbourne, Florida) |
| ABSTRACT | A satellite communication system includes satellite nodes moving in respective known orbits, and a controller configured to determine routing neighborhoods for each satellite node based upon the known orbits, each routing neighborhood comprising a group of adjacent satellite nodes; and assign a respective primary neighborhood egress node (NEN) from among the plurality of satellite nodes for each routing neighborhood. A given satellite node of a given satellite node routing neighborhood may be configured to reroute a failed path from a source satellite node to a destination satellite node through the given satellite neighborhood using a secondary NEN instead of a respective primary NEN. |
| FILED | Wednesday, November 03, 2021 |
| APPL NO | 17/453348 |
| CURRENT CPC | Transmission H04B 7/195 (20130101) H04B 7/18534 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 45/28 (20130101) Wireless Communication Networks H04W 40/20 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230137253 | Sun et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | Raytheon Company (Waltham, Massachusetts) |
| INVENTOR(S) | David Yu Shan Sun (Rancho Palos Verdes, California); Alfredo Rene Lara (Norwalk, California) |
| ABSTRACT | An apparatus comprises a toggle member, a plurality of pogo pins, and a test board in operable communication with the toggle member. The pogo pins are coupled to the toggle member to move along a first axis when the toggle member moves along the first axis. Each pogo pin includes a plunger that moves within the pogo pin along the first axis. The pogo pins and respective plungers contact a top surface of the DUT when the DUT is coupled to the test board and positioned so that a conductor on its outer surface is aligns to and contacts a conductive region of the test board. Movement of the toggle member along the first axis translates to the plungers, applying a pressure sufficient to the top surface of the DUT to ensure flushmount electrical contact between the conductor of the DUT and the conductive region. |
| FILED | Friday, October 21, 2022 |
| APPL NO | 18/048558 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 1/0408 (20130101) Original (OR) Class G01R 31/2891 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20230139942 | Baek |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (Seoul, South Korea) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Seung Heon Baek (Seoul, South Korea) |
| ABSTRACT | A neuromorphic device including an electrode including a first terminal connected to a bit line through a write drive transistor and a second terminal connected to a source line, a plurality of unit weighting elements having different resistance values, each of the unit weighting elements including a free layer arranged on the top of the electrode, a tunnel barrier layer arranged on the top of the free layer, and a fixed layer arranged on the top of the tunnel barrier layer, and corresponding to each bit of a synapse weight, and a plurality of control electrodes connected to the bit line through a plurality of read drive transistors, respectively, a control voltage being applied between the free layer and the fixed layer of each of the plurality of unit weighting elements through each of the plurality of control electrodes. |
| FILED | Thursday, April 14, 2022 |
| APPL NO | 17/721037 |
| CURRENT CPC | Static Stores G11C 11/18 (20130101) G11C 11/54 (20130101) Original (OR) Class G11C 11/1673 (20130101) G11C 11/1675 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, May 04, 2023.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20230504.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
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